<?xml version="1.0" encoding="UTF-8"?>
<uniprot xmlns="https://uniprot.org/uniprot"
 xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"
 xsi:schemaLocation="http://uniprot.org/uniprot http://www.uniprot.org/docs/uniprot.xsd">
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2EBL0</accession>
    <name>A0A8J2EBL0_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">EGF-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS597</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001114">
        <property type="protein sequence ID" value="CAG5073773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2EBL0"/>
    <dbReference type="OrthoDB" id="504708at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39069">
        <property type="entry name" value="ECDYSONE-INDUCIBLE GENE E1, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39069:SF8">
        <property type="entry name" value="FI17111P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EGF-like" evidence="1">
        <location>
            <begin position="40"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="1">
        <location>
            <begin position="81"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="1">
        <location>
            <begin position="129"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="1">
        <location>
            <begin position="274"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="1">
        <location>
            <begin position="358"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="1">
        <location>
            <begin position="433"/>
            <end position="475"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5073773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="478" mass="54385" checksum="8B14CD575289E9A6" modified="2022-05-25" version="1">MFDSDCKSQNHIICSEDNECVCKKNYIKIGLSCRPLIGSFCKKNEDCFPENSVCVDHKCKCKEYFVPKSYERCEPTYFHSKCNSRDELCQEAQFFSCTNDGKCFCPPNHIVSNDKCLPLLNEHCVENEECLIDFSSCVNNQCQCRPEYAAQDNNLCLPTRLNYKCKFDEDCSKIHNSKCSEFKGCICRKNYYQLTETICSPSIGGPCASNMDCTVENSFCIKNSCKFLYKSCHLDEDCVNIKFSKCSSNNECICEPNYLASTDKTSCLPLIGGECELDEDCVTENSNCYSRKCQCKKYFVPNVIDGKNECERRLPCSNHIDCALTQNFLCSDDKVCACRKNHHEFNNKTFCTPIINEECSTDKDCRFDNFHCFNFTCQCKPNYFAVSDTQCEIEQSVVHCSDNIDCGDPWHAECSINNYCVCKSNNRLINKATCYPLLGGPCWKDDQCSLPNSVCIDYRCKCQSGFKAVATNLCIPAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2EC24</accession>
    <name>A0A8J2EC24_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Similar to ifi30: Gamma-interferon-inducible lysosomal thiol reductase (Carassius auratus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HICCMSTLAB_LOCUS2213</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GILT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001117">
        <property type="protein sequence ID" value="CAG5076536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2EC24"/>
    <dbReference type="OrthoDB" id="958254at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016671">
        <property type="term" value="F:oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004911">
        <property type="entry name" value="Interferon-induced_GILT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13234">
        <property type="entry name" value="GAMMA-INTERFERON INDUCIBLE LYSOSOMAL THIOL REDUCTASE GILT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13234:SF8">
        <property type="entry name" value="GAMMA-INTERFERON-INDUCIBLE LYSOSOMAL THIOL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03227">
        <property type="entry name" value="GILT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035248819" evidence="6">
        <location>
            <begin position="24"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAG5076536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="224" mass="24287" checksum="7CED5491E716E3BE" modified="2022-05-25" version="1">MHSSISSVFVATFALAYFSVTSGCSQKACVGVTVYYESLCGDSLRFIKGSLVPTYAELKDYLDITFVPYGKASHERDQATGGWNFSCQHGPPECKGNKAQACGLYAIKSEEKTEDQQDLSVRFVGCAMSSDDPSSNAQQCAVSVGLKSSTQELLNKCESDVTGDNLLANYGEMTHSLRPQLSFVPTIVINDKFTGENQLMALTQFKKLICNNLPSDVKPPTCGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2EFB4</accession>
    <name>A0A8J2EFB4_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS387</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001114">
        <property type="protein sequence ID" value="CAG5073444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2EFB4"/>
    <dbReference type="OrthoDB" id="10368434at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5073444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="116" mass="13489" checksum="E5D1523ADF8C3F6D" modified="2022-05-25" version="1">MYPINVNFENNRTWFQYVTAVFGEQDLRHGIKLLRRMQASLTPGEALDLVGKWLVLFGPAGPEVTKFSQKFSRKMLEDPRTHQQFFAPNLSKLERLRQALADYVLNRYSSPDKLSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2EGW6</accession>
    <name>A0A8J2EGW6_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS1398</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001116">
        <property type="protein sequence ID" value="CAG5075244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2EGW6"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5075244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="72" mass="8731" checksum="50FF960610C0D9B5" modified="2022-05-25" version="1">MAEQPRQKKVKYETSFNERWKKNHLYADWMRKIDEKTVKCVYCSSQFTIKWDGETALTKHMNSTMHKKNTSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2EHG9</accession>
    <name>A0A8J2EHG9_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS1778</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001116">
        <property type="protein sequence ID" value="CAG5075624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2EHG9"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5075624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="92" mass="9293" checksum="44D802C5683E5D23" modified="2022-05-25" version="1">MYCGEPSRGVIGTVTLGGTYGEFSTCMGSATGGWGIIIGLIVNFGIGCGSEITTVGITAFDDVGVLGVLGGHPPISLVFLGIRDNGGLKQER</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2EHM1</accession>
    <name>A0A8J2EHM1_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS1869</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001116">
        <property type="protein sequence ID" value="CAG5075803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2EHM1"/>
    <dbReference type="OrthoDB" id="6343941at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21261">
        <property type="entry name" value="BEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21261:SF15">
        <property type="entry name" value="BEATEN PATH IIIA, ISOFORM D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ig-like" evidence="1">
        <location>
            <begin position="35"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5075803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="78" mass="8640" checksum="86EECE4B794400BA" modified="2022-05-25" version="1">MEGKYRCEVTNDIPDFHTLRKVGYMHVVSLPQGSPEVLVEKQRYAIGETVKANCTTPPSNPATNVTWTVNGIPVPENL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2EJW5</accession>
    <name>A0A8J2EJW5_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similar to NOF: 120.7 kDa protein in NOF-FB transposable element (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS1526</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001116">
        <property type="protein sequence ID" value="CAG5075372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2EJW5"/>
    <dbReference type="OrthoDB" id="7690546at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="223"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5075372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="247" mass="28204" checksum="CD5534707B566CA0" modified="2022-05-25" version="1">MHCYKEYHRTHKDFSSIAIDATGKFVRKIVFPDGEKSQYIFLYQIIINFDKNSQSVWQMLSAAHDAETIRLWLVKWVSLGARHPREAVSDGSRVQLNAMSSAFNLTPLKTYIAICFKNLHRHKKTPINTYIRLDAAHFVHSITGWKYFKSVLHPSIKQFYIRCICLLIDCTNLDDFQRILLLILVICNVAHEDSTIDIEGEMISPLGANHNPAPWTSTQSVFSQETSPHLSDTAPSKVNFSPPKNGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2ENH7</accession>
    <name>A0A8J2ENH7_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Similar to FAHD2A: Fumarylacetoacetate hydrolase domain-containing protein 2A (Homo sapiens)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HICCMSTLAB_LOCUS1648</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001116">
        <property type="protein sequence ID" value="CAG5075494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2ENH7"/>
    <dbReference type="OrthoDB" id="411064at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050163">
        <property type="term" value="F:oxaloacetate tautomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006107">
        <property type="term" value="P:oxaloacetate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.850.10:FF:000002">
        <property type="entry name" value="2-hydroxyhepta-2,4-diene-1,7-dioate isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.850.10">
        <property type="entry name" value="Fumarylacetoacetase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051121">
        <property type="entry name" value="FAH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011234">
        <property type="entry name" value="Fumarylacetoacetase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036663">
        <property type="entry name" value="Fumarylacetoacetase_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42796:SF4">
        <property type="entry name" value="FUMARYLACETOACETATE HYDROLASE DOMAIN-CONTAINING PROTEIN 2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42796">
        <property type="entry name" value="FUMARYLACETOACETATE HYDROLASE DOMAIN-CONTAINING PROTEIN 2A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01557">
        <property type="entry name" value="FAA_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56529">
        <property type="entry name" value="FAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fumarylacetoacetase-like C-terminal" evidence="3">
        <location>
            <begin position="126"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG5075494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="333" mass="36464" checksum="C787C0B74E6A75BF" modified="2022-05-25" version="1">MFHYGKLQRLSHFMQYKSSLITINSNINQVFNLSKNFSTTGAQKMRFVQFTNKKGGPQHLGVQLKAGGDIIAISSIDSRIPNTLKKFLEGGETISNKAKRIIVESRSVIPEAEVNLLAPINRMDKLACVGLNYSGHCSEQGLEPPTSPVIFNKFPSNIIGPTDDILLPSNSDKVDWEAELAIVIGKSGKALSKEDAENCIFGYTVAQDLSARDWQKGKRNGGQFLLGKAMDTFCPLGPAVVTKESIGDINNLSVQTWVNGKLKQDGNTSELIFKPRDIVAFISQFMTLLPGDVILTGTPAGVGFTRNPPEFLKKGDILETEIHSLGRLKNNVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H0A9</accession>
    <name>A0A8J2H0A9_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Endonuclease/exonuclease/phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS118</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030000696">
        <property type="protein sequence ID" value="CAG5071969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H0A9"/>
    <dbReference type="OrthoDB" id="7699669at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061343">
        <property type="term" value="P:cell adhesion involved in heart morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007508">
        <property type="term" value="P:larval heart development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33395:SF22">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33395">
        <property type="entry name" value="TRANSCRIPTASE, PUTATIVE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5071969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="431" mass="49915" checksum="B9FE57D315973EF4" modified="2022-05-25" version="1">MARNDRDPTLSGQEHGGGVFIAIKRHIHADLIPIDDCNLELVFVKIKGTVSDIIVGCVYMPPLTSYEEYHSLLTTLTHVNEKFINAKLLLVGDFNLPSSVPRADCDKSVHDGLALLECTQINSLCNYNNNLLDLCFSNVEASIDKALPFVSEDKYHPAFTVYLEFQPNLTPLSPATYSFKKADYHNLNTFYHQVNWIELYETDTVENKVKWFYSKLEEGISRYVPVHRKFVSTYPCWFSYELINKIKLKKSAHSQYKKMKNQQNYTRFSILRRDCKILSAEYYRNYVDKIENMVQTDTNAFWKFIKDKKHNNTDIPSSMSWINQSASTGQDISNLLVDRRQVADLTFFYKVANGQIDAPEILSSFEFAPSTLSLRHNRLLKTTKTHKNYVFREPHNRIANLVNSLHTDINFYGGTYQAFITNTKNKILPYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H5D7</accession>
    <name>A0A8J2H5D7_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS1735</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001116">
        <property type="protein sequence ID" value="CAG5075581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H5D7"/>
    <dbReference type="OrthoDB" id="7697635at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5075581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="129" mass="15418" checksum="4961144D9FEB61A5" modified="2022-05-25" version="1">MGEDRWPKICLREEMRGILNRQPSKWGEKIKMLVKEMECERVIELIYNNAEIEVIEEEIKNGLEVYKKMMEKKVEEKINNSTYSNLYKKLVLTNETENYWCDKEVKNTDKEIWARARSGNLTRAGKKKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H5J9</accession>
    <name>A0A8J2H5J9_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS2190</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001117">
        <property type="protein sequence ID" value="CAG5076448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H5J9"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5076448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="27" mass="2851" checksum="E3A6807501122DF0" modified="2022-05-25" version="1">MDLDSSSSSSSSNSSNTAKLTNWVECL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H5N8</accession>
    <name>A0A8J2H5N8_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to REPTOR: Protein CREBRF homolog (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS1310</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001116">
        <property type="protein sequence ID" value="CAG5075156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H5N8"/>
    <dbReference type="OrthoDB" id="8931646at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006986">
        <property type="term" value="P:response to unfolded protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14809">
        <property type="entry name" value="bZIP_AUREO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039165">
        <property type="entry name" value="CREBRF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21552">
        <property type="entry name" value="ADULT RETINA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21552:SF2">
        <property type="entry name" value="CREB3 REGULATORY FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BZIP" evidence="2">
        <location>
            <begin position="480"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="335"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="335"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="354"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5075156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="565" mass="62188" checksum="F6FB04BA925B1ECB" modified="2022-05-25" version="1" fragment="single">MYYLENTISLDDTKMGDSFQEFILSDLNSSQMNNLIKQEPSGLEVTSASASVPIPGSHRGVRGIYDQFSPSPLTLPSMWGCRVEPEDYSIDPEQLGITFKMEDDDIFQVDKADLIQGPTLAELNANDDILLGDLNFDDLLLPEERMQPVSPQTVVPQIPVPLAPAPLVLGSNVGLLTTGISGFAASYPSSTITFKPTTTYSTNSAGTFDNEVVYVSPSTSHIAESMDSCYDIGSSTASSSTSPHMIPTNVNIAVDNPSMNNKPVTVGPTSTLHELLMRKVESNTMSPIKRVDPVPMDIVNNSKIKVSRLSMSAPTQSLGLEQIWARREPRRHLLSTSSIGVAEVESTSNSGSDGEDHSSIRDSRDPTASSSGPSKMSKKEKYFWQYNVQAKGPKGQRLIAHKRLEDPHVLNQATDPVFSPSCSLRGIKHSGKARKGDGNDLTPNPRKLYIIGKELDKLSRIINDMTPVSELPFPARPKTRKEKNKLASRACRLKKKAQHEANKIKLHGLEIEHKRLINGIAQIKTILAVKLTEQSSEKQEELTRQMDKICKSSTSKFFNYLLFCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H687</accession>
    <name>A0A8J2H687_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to spop: Speckle-type POZ protein (Xenopus tropicalis)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS2523</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001117">
        <property type="protein sequence ID" value="CAG5077653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="7555121at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030163">
        <property type="term" value="P:protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00121">
        <property type="entry name" value="MATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.710.10:FF:000159">
        <property type="entry name" value="Speckle-type POZ protein B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.210.10">
        <property type="entry name" value="Apoptosis, Tumor Necrosis Factor Receptor Associated Protein 2, Chain A"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002083">
        <property type="entry name" value="MATH/TRAF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008974">
        <property type="entry name" value="TRAF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24413">
        <property type="entry name" value="SPECKLE-TYPE POZ PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22486">
        <property type="entry name" value="MATH_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49599">
        <property type="entry name" value="TRAF domain-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50144">
        <property type="entry name" value="MATH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MATH" evidence="2">
        <location>
            <begin position="166"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="337"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="domain" description="MATH" evidence="2">
        <location>
            <begin position="528"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="700"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="940"/>
            <end position="1007"/>
        </location>
    </feature>
    <feature type="domain" description="MATH" evidence="2">
        <location>
            <begin position="1125"/>
            <end position="1259"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="1298"/>
            <end position="1365"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5077653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="1444" mass="167260" checksum="17D0FFCB13106F75" modified="2022-05-25" version="1">MSYLVCLDMVTFITLQPIKKGGQLFISYGPEFHIMPTPKRREELQNNRSYWCDCHACINNWNPEHVFPSTSNKIPKKIATDMSMIFFECIVQIQRQNFYDHDTTSPEEIEKLMSRIFTIINLVGRYVIYPCEETSVGKCFLYSIIRWIESYQPPIDSGYTFTKKHVILYEWRINEISSYVEKNDDEVIYKLDLESPKFSVGADEEKKWYLRLKSASDLDLDKTWLSLFLHYSSSKESEVKTKYLLFILNDKKERVNVSEFHKWFKNDGDGWICAEFVKKADLEEKKDELLPDDTLTIGIELTVYDDSTTFCTYITLEEPKSQMVADYKRLFESKEGCDVVIKVKDETFEAHKTILMARSEMFFKLFTVEMKESKEEFITLSDIEPEIFKSLLEFIYTDEVSYLDVVVEDLLEAADRFLIESLKNMCVESLIKLLNIDNAVRFLSLAERHNAPQLLTHVTDFIVLNVEDIIKSREFEIMEKSNPSLALILFRKFAALKTDGTFLFSDPVKEVLFTMKKEKGYTSVKKHQIEYHWKINEISSYIKCYREKPEINTHLLSPTFSTGSKMDDAWKLTITFNDHDSDEYKDWISIYLNPFNQQKVIEFKTDYTLFILDNKGEMVERENTKYIFNDFHGYGFPDFCTKKKLLENPDTHIPNDTLTVGIILTVFDSSTFSNNDTVDDEPRGFMIGDYTKLYEDENMPDLVVKVKHETIKAHKTILMARCPLFSKMFSIKMKSREEEINIPDVDSDTFYSFLEFIYTEEVIDLDDYAEALFEFASKYKLEELKKMCAKSLYKTLNIDNAPRLLVLAKECDALELLDYISEFIVINSGQIIETPEYRSIGESNPAIGIILLKKFAEWKLSGNLELNDNYGDSSICSKFVKKADLEEKKKELLTYDTLTIGVELIVYDGSTTISTSITLDEPKSQMVADYRKLFESKKSCDVVIKVKDETFQAHKAILMARSEEFFKLFTVEMKESNEEFITLSDIEPKIFKSLLEFIYTDEVSDLDVVVESLLEAADKYLIKSLKNMCVESLIKLLKIDNAVRFLFLAKRYNAPQLLTLVSEFIVLNAENIIKSREYDIIKSNPSLAIILIRKLAALKANGTIRLADPVKRSMKRGYVVTNKHIVKFEWKIKNINSHVKFETDDENKDIKLHSSSFSAKANGDLWKLHVQFNNAHQSVNKDYMSLCLQSLRNDLKVKTKFILYILNHKKEMTNDNVLYMTFENDEVAYGLPEFVRKKDLVDPKKKLLSHDSLTVGVELVVFDNPDNKSSDTTNELMIKPSNQLVQDYKQLLDSKAGSDVTLIAGDRKFKAHKSILLARSPAFSKMFSENQFQVLKAPIMIHDIEPEIFEKVLEAIYTDEVSDLDEHAEDLLEAADKLQLQSLKQMCEQSLSKTLSVDNAIVALSLAVQYNAKELIDYVADFIVSNAEQVVTTPEYSVYYDTKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H734</accession>
    <name>A0A8J2H734_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Gustatory receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HICCMSTLAB_LOCUS3156</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Cell membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the insect chemoreceptor superfamily. Gustatory receptor (GR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5080968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H734"/>
    <dbReference type="OrthoDB" id="6366728at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050909">
        <property type="term" value="P:sensory perception of taste"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013604">
        <property type="entry name" value="7TM_chemorcpt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08395">
        <property type="entry name" value="7tm_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="31"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="127"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="208"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="239"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="326"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAG5080968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="367" mass="41644" checksum="616FBE7DF0D49FE6" modified="2022-05-25" version="1">MENAKEFTFELRTNVTPPQLINQIQNKICKFSYIGSGYNVFLVLVYALYNFYYLFFPEEGEVSVIGNQTYVKVMNVASFITTLSKSLINIIDRLISVNQKLSISADSYSKDFLNSVRAARFALSTNFANVVCSWIIVQFTLLLGIVGKQIEAVNLSINKIDDVRSDLAQIPALRVNRLLEDESACREINYIKRIYIELWEISGEINNLYGLTVLISLLLFSFEIIVSLHMIFTLPLLKALSFIFLHIATGMIAPWRIFLFFGANFCSFQNYRSGMSKKTGQIISLLSNRRPINPKVKEQLYKFSNDLSHFKIEFSAYGVLPLNRDLLGIASGTIATFLTIIIQGAGILRTLPSDIERELARMKKALD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H744</accession>
    <name>A0A8J2H744_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Similar to lmo1: Rhombotin-1 (Xenopus laevis)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HICCMSTLAB_LOCUS3215</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5081192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H744"/>
    <dbReference type="OrthoDB" id="6352355at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140297">
        <property type="term" value="F:DNA-binding transcription factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000015">
        <property type="entry name" value="LIM domain only 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050945">
        <property type="entry name" value="LMO_RBTN_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45787">
        <property type="entry name" value="LD11652P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45787:SF1">
        <property type="entry name" value="LIM ZINC-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0440">LIM domain</keyword>
    <keyword evidence="1 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="LIM zinc-binding" evidence="6">
        <location>
            <begin position="19"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="LIM zinc-binding" evidence="6">
        <location>
            <begin position="83"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAG5081192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="119" mass="13568" checksum="7B0C22A265B9DB98" modified="2022-05-25" version="1">MTMDVSKSETNKNGSAQQEICAGCHKTITERFLLKALDLLWHEDCLKCSCCDCRLGEVGSTLYTRANLLLCKRDYLRIFGHEGHCSACSKSIPPFEMVMRARTNVYHLECFACQQCNHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H7A3</accession>
    <name>A0A8J2H7A3_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS3341</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5081638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H7A3"/>
    <dbReference type="OrthoDB" id="6350415at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5081638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="81" mass="9685" checksum="9FE8A4BFFC136EC5" modified="2022-05-25" version="1">MPTNHTQKSHDLQFSNGTQTFTYNYHNYKIENMDFDETSFTVKCNNKVILIGNNSPRLKEIIRYDGTDYHRDPETMMYQKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H7N2</accession>
    <name>A0A8J2H7N2_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Olfactory receptor 93</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HICCMSTLAB_LOCUS3409</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5081911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H7N2"/>
    <dbReference type="OrthoDB" id="6617147at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005549">
        <property type="term" value="F:odorant binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004984">
        <property type="term" value="F:olfactory receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004117">
        <property type="entry name" value="7tm6_olfct_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21137">
        <property type="entry name" value="ODORANT RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21137:SF35">
        <property type="entry name" value="ODORANT RECEPTOR 19A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02949">
        <property type="entry name" value="7tm_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0552">Olfaction</keyword>
    <keyword evidence="8 12" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="9" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="31"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="123"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="194"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="260"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="296"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="220"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAG5081911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="393" mass="45175" checksum="4E9D910354C87D8F" modified="2022-05-25" version="1" fragment="single">EQRELDKGVKVFSWVRLISKLIGIWPLDPNYYLYNICITYFTYIMITEYIDLYFCLPNFKKVINNLTESLAFTQMYVRGIMLRVHIKKLQRITAESVKDYQVSAFKNPDEVYEFLSYVKRGKFFVRAVTIFILSTTTSWFLRPITSSTPSTSIIPGDNETAPKFTYILPYKFHVFYKINDQRTYALTYMSHAPFAYVSVISAITSATLLIALSFHVSGRLAILARRISALKNSNEKLRTEINEIIFEHTRLLDMGEEIKVSYAAALLVYLVVGTIQLCIIGYHILVVISMGKQHSLMPFFVFIITTYGLISIYCILSENLLAESKKCSEAFWCCEWYEMPQDCVKDIAYCIMRAQKPLGLTAGAFVVFSNSTLTDVTKTSMGYLSILRNFLVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H7P8</accession>
    <name>A0A8J2H7P8_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Similar to NELF-B: Negative elongation factor B (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS3538</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5082355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H7P8"/>
    <dbReference type="OrthoDB" id="5548359at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032021">
        <property type="term" value="C:NELF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034244">
        <property type="term" value="P:negative regulation of transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010405">
        <property type="entry name" value="COBRA1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13503:SF3">
        <property type="entry name" value="NEGATIVE ELONGATION FACTOR B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13503">
        <property type="entry name" value="NEGATIVE ELONGATION FACTOR COMPLEX MEMBER B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06209">
        <property type="entry name" value="COBRA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="1" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5082355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="710" mass="78431" checksum="E7BDE3364E29852C" modified="2022-05-25" version="1">MTTKNNGRAAGDGLENLGVPGQVFLRDSLTSCTDPLSAIEQFQIDNGILLASLRPMLPLLDLHGVRRLDFHASVLEELREKLVKRINEIGTEREKSGSSGDKRLKDLLSKSFPAIRVPALRPVVMSILRNTPHIDDKYLRVLVREKELYNSAETEVKRQIWKDNQSLFGDEVSPLFSKYIIEKEQVLFDHGNLNSLFFSPSPKVRRQGEVVQKLAHMIGTSVKLYDMVLQFLRTLFLRTKNIHYCTLRAELLMALHDLEVQEIISVDPCHKFTWCLDALNFLASSAIKIALHLINGESLPRDNAVLVLLLRMLALGLSAWQMIDSQDFKEPKLDSQVVTKFLPALMSLMVDDQIRQLNCKLPPDERESAIAIIEHSGPPPDACQAYAQLSGVAAVLSMYYTLHVGGATGGFGAASSGGAGGIGGVGTGAGKSRSDSRGLMRVLSILPNCQGHRAFEDPFLHTLVSLLILNMADEFSNESFCTVIFDEFFLAGLGRDNVTRHLLKLLWYIYPKLPTARLHSLMKGLQPTNQNWLNLRSHRFSTGGFGAASSGGAGGIGGVGTGAGKSRSDSRGLMRVLSILPNCQGHRAFEDPFLHTLVSLLILNMADEFSNESFCTVIFDEFFLAGLGRDNVTRHLLKLLWYIYPKLPTARLHSLMKGLQPTNQHNEAVHTLFEALREKIGSRTMEEATLGQDTMGMDCSASPLGVSVPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H826</accession>
    <name>A0A8J2H826_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS3780</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5083250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H826"/>
    <dbReference type="OrthoDB" id="7689611at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="653"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="655"/>
            <end position="668"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5083250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="698" mass="81203" checksum="0089925B2C0F5EED" modified="2022-05-25" version="1">MMTSHTFASTLTNIKINCTIIPFEKLSLGDTIDETFAVVYGNIINSNNEIPSIIKSLTKSVKNLPTWSTAQFTCSKTLNSLFEDSVEEKNLFKKFDKRKINDQLFNIDKKYLNNNHTCLLFELCKSEKQTYEEFVNIFEEKYFDKHYDDYYWYHEYRPQGKHIEILKFIRGNETHFVSAIHNGDCLYQIFIFNTESENTSAEIDYKKKTPEYTSKIKMASDNHIFEESLTYSLNTSHIFLFNFPNIPLKVTHEVLNYLSLYNVMSVELTALPKLPRSLEFKEDEIESPKKRSKLVELEAGDSFNINDLISNSVLKSRNMLDFKIFNSIEYSNPYSLQVTNYSDIIMDRSLPCREFVTKYFGDKNNKDYEKLKPFNCLLEEKSYGIDEKFFNENYTRDEIKICLVLEEQKMGIDPLEIVYLNEKTVDGDYNIFENENVVLRFRKSNETHYVSSIQFGNCLYQALVYNLDDQKKPVHKGKILSASRNSDLEKTIEDYLNNSKIDSLYNIYSNEKLKNEIIERLDKEAVVNIDLRSINKKRSLPLLTLSEYNNLKKNSSENLPIKTPEVSQELLTAIFKNLSEPNEAFKTFIQDLFTATFKNMSQDLFPGALENLSTESPDDFLADASKNSLQELLTDTFNNSLKNSSTEILKKKNSSQELLTDTSNNSRTETLKRKNSSNSMQPSLLSLVLILTTVYMYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H898</accession>
    <name>A0A8J2H898_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HTH CENPB-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS4028</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5084145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H898"/>
    <dbReference type="OrthoDB" id="7697906at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006600">
        <property type="entry name" value="HTH_CenpB_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03221">
        <property type="entry name" value="HTH_Tnp_Tc5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51253">
        <property type="entry name" value="HTH_CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH CENPB-type" evidence="2">
        <location>
            <begin position="96"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5084145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="378" mass="42440" checksum="82FE230E4B3643E1" modified="2022-05-25" version="1" fragment="single">VTCQQRTIKKILIGNCKNGETTTVSTSKKKVLRSKVTDKITKKKVRKLKYTPIDVENALKAMKNTGLSLWKAAVTFGVPLATLGRKKSIGPDEIKKKSGPETVLSSQEEDHIVKWALDRAAMGAPVTKTELLDCVQKYVQKLAKKTPFTDNRPSRHWYEGFRKRHPELSIRKPQHLSVSRAAVSCEELQEWFKNTGAYLESKNLSNISPTRIFNCDESSLLLCPDAESVLAEKGSRAVYKIVDGGKEALTVLFMYRADGVRDNMKNEKNVVVSGFKGSGLYPFDPKVVDYDILQKGKKSKEAINQKENNLDSDISEDKQFLLKFEKNLQPDTLSEFQNAAASGLWIGAVEKKGLFEYWLEISKNTTNVSSKQLNSIDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H9E7</accession>
    <name>A0A8J2H9E7_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS4910</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5088610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H9E7"/>
    <dbReference type="OrthoDB" id="20872at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="85"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5088610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="129" mass="14891" checksum="A8CFEF2CAAC34F7B" modified="2022-05-25" version="1">MDCLLSMITCTQHLKVSGKEINVTVVEELLNQPENNVNMTLFDMDRPFRNHTTFLCIAVRNRDEELIDYLINRKADVNKGDLIFEDENPLHIAVENGDLKVFQKLYQLGAKLHLQTSLRRSLSRDTSES</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H9G9</accession>
    <name>A0A8J2H9G9_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS3894</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5083645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H9G9"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="45"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5083645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="106" mass="11329" checksum="9C8C56AA196F347B" modified="2022-05-25" version="1" fragment="single">YLKVQFTLPFAAVIFFIEARLFSASFEEFSSSEPLLPSSAPPSTLPGISSTGLPSSTTSSVSLGSMDIGTSTSTNPALKYKNDVIIGRVGRGQTKSRQKNNETHLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H9Q8</accession>
    <name>A0A8J2H9Q8_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similar to Sspn: Sarcospan (Mus musculus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS3555</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5082414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H9Q8"/>
    <dbReference type="OrthoDB" id="7685256at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016010">
        <property type="term" value="C:dystrophin-associated glycoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042383">
        <property type="term" value="C:sarcolemma"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030429">
        <property type="entry name" value="Sarcospan"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15260">
        <property type="entry name" value="SARCOSPAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15260:SF1">
        <property type="entry name" value="SARCOSPAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="185"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="217"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="258"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="326"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5082414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="386" mass="42478" checksum="226C990880A97316" modified="2022-05-25" version="1">MFKKMRAHWADGSPPPCAQVQVQNQDEEEDSTGIQCNLTTQADSLYNDFKDTSTMPPCVTSTMSVGDSNQMTISATELELQDNNNQVNTPASAPKTQGAATIGWSIPVKDNKTMKSNNCDRAPSMANCLSTTVPVNLKASQIAGRHTPTRSSLRHSRMIVMHRTGNIPRKSRPPLLRRRKLSSTLAAIQTILGIAVTSLSLWLLLWAPNLPFMDNPYWSGMPLLFSGSFGICLLCCFKKEYPGLSPGFCLTATKVMSFFLAALAAITCLVACITSAIHLIRLSGLECTPARVINATCACRSRSELASTSEPVFKYVDLNCPEVEGVLTILLIFSSICNALGAIIAGWYCYLHWSTRDKRPQYFKVRSSTRAPLDSRPIYNPNLNRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HA54</accession>
    <name>A0A8J2HA54_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cc_p6.9_1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS5450</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5089987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HA54"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5089987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="60" mass="7122" checksum="3F467F4B1BA02624" modified="2022-05-25" version="1">MARSRSRSRSKSKSRKGSRGRSRSRSRSNRRSLSRRPKSTKRVGRRVNRRKSYKARSTSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HA60</accession>
    <name>A0A8J2HA60_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="6">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HICCMSTLAB_LOCUS5014</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="6"/>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5088882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HA60"/>
    <dbReference type="OrthoDB" id="6846267at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00312">
        <property type="entry name" value="Esterase_lipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019819">
        <property type="entry name" value="Carboxylesterase_B_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43142">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43142:SF1">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00941">
        <property type="entry name" value="CARBOXYLESTERASE_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0719">Serine esterase</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035173669" description="Carboxylic ester hydrolase" evidence="7">
        <location>
            <begin position="16"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="8">
        <location>
            <begin position="26"/>
            <end position="533"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAG5088882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="566" mass="63635" checksum="38BAD9F2FAC7EE86" modified="2022-05-25" version="1">MKTAIILCLVPLALATLDIEKTPDGPRFETPMGGIRGFYDYSEHGRKYMAFEGIPYAKPPVGDLRFRPPQKMKSWSGDMVAIKTGPPCTQYIHTPIDAKERIVGSEDCLYLNVYKPVTESTKKMPVIVWIHGGAFQWHMESKDGQFTKPHYLMDRDVILVSFSYRVGPLGFMSTGDEHISGNMGLKDQNMAIRWVKENIEGFGGDSENISLFGLSAGGVSVHYHYLSPLSRGLFKRGLSFSGNALNCWAITEGAPEKAKKVAMTVGCPTTNTEEMVKCLRTRPYRQIARTDMDFMPFEFNPMTPFGPVVEKSTAESPFITKIPAEIISSGEAYDVPWITGVVPEEGLYPGADFCADPVYLKELDARWDTLAPFILDYNYTVPVTKHVEVGRKIRHHYMGDKPIDKSTAMDLVHMIGDRLYVVGGVKAAKLMAKANKSPVRYYYFTYHGADSLSYSMTRTHEDWGVAHGDDPYYIVGSPFMDPTTTPEDRAMQRELLDLWVSYATHGTPDVGFDWTPVDAAHEKLVYLHIKGPGHKEMDKDGNFGSYKLWSSIDFYEDKVDGRKIDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HAB5</accession>
    <name>A0A8J2HAB5_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Similar to gabT: 4-aminobutyrate aminotransferase (Dictyostelium discoideum)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HICCMSTLAB_LOCUS5400</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5089849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HAB5"/>
    <dbReference type="OrthoDB" id="5419315at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009450">
        <property type="term" value="P:gamma-aminobutyric acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43206:SF1">
        <property type="entry name" value="4-AMINOBUTYRATE AMINOTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43206">
        <property type="entry name" value="AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000521">
        <property type="entry name" value="Transaminase_4ab_Lys_Orn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="5 6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAG5089849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="445" mass="49533" checksum="34BFE35ABEE59D05" modified="2022-05-25" version="1">MGDWSMRSIDKFFRIIIKLLFINDAGDRNTWRRCLTTATCVEPKGPSLKTEIPGPASRQLFNELNKFQQAATVQLFADYDKSSGNYMVDVDGNTLLDVYMQISSVPLGYNHPAMLEALSDPHNQRAIVNRPALGVYPGADWPKKLKDVLFRPGVAPKGLGNITTMMCGSCSNENAFKNIFMWYAEKNRGGKPFTKEEMESCMVNQIPGSPKYSIMSFQGAFHGRTLGCLSTTHIAGIIIEPIQAEGGDNHASPEFFQQLQKLTKKYGIALLIDEVQTGGGPTGKMWCHEHFNLPSPPDAVTFSKKMQLGGYYHTAELRPNQGYRVFNTWMGDPSKLIMLEAIVNIIQRDNLLEKVSKVGEYTLDNLKKIEKEFSTVINSSRGRGTFIAFNGATPQIRDQIVKKLLAKGIQAGGCGANAVRLRPALTFDRLHADIFLDALRKVLKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HAH8</accession>
    <name>A0A8J2HAH8_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS4072</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5084308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HAH8"/>
    <dbReference type="OrthoDB" id="899at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="74"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5084308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="259" mass="28887" checksum="5A9AF53397E97A89" modified="2022-05-25" version="1">MKNFVIIFLLSNLESSSKLDISTIEDLPDKLTASEPTIDGHQLQFNCLANGQSNREPATQRPVADVASQSGLRPQAPQQIMQPQQHQGQSTLNIAGEMPRQANVIRGPVGQVGSQGQGSGPQMQRQALQQYTQILQQFRQQQQQQQTHMVNQARGQSPHHQVHQVGIVDLGQGGSRWIQARPNMHNIQNMGQMGVSSPYGYVPTLNQCTLTVPTPNQCTYTVPTRDQSSYLQTQVKPVQQVKFWQLSLSEENRKVRSKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HBI7</accession>
    <name>A0A8J2HBI7_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 13">Histone H4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">HICCMSTLAB_LOCUS6336</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="1 13">Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5 13">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 13">Belongs to the histone H4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5092719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HBI7"/>
    <dbReference type="OrthoDB" id="8179904at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22912">
        <property type="entry name" value="HFD_H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000012">
        <property type="entry name" value="Histone H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001951">
        <property type="entry name" value="Histone_H4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019809">
        <property type="entry name" value="Histone_H4_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004823">
        <property type="entry name" value="TAF_TATA-bd_Histone-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10484">
        <property type="entry name" value="HISTONE H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02969">
        <property type="entry name" value="TAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00623">
        <property type="entry name" value="HISTONEH4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00417">
        <property type="entry name" value="H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00047">
        <property type="entry name" value="HISTONE_H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0007">Acetylation</keyword>
    <keyword evidence="7 13" id="KW-0158">Chromosome</keyword>
    <keyword evidence="10 13" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-0488">Methylation</keyword>
    <keyword evidence="12 13" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="11 13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TATA box binding protein associated factor (TAF) histone-like fold" evidence="15">
        <location>
            <begin position="59"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="14">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00020836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CAG5092719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="117" mass="13099" checksum="91627167B819359C" modified="2022-05-25" version="1">MTGRGKGGKGLGKGGAKRHRKVLRDNIQGITKPAIRRLARRGGVKRISGLIYEETRGVLKVFLENVIRDAVTYTEHAKRKTVTAMDVVYALKQSIKYNIIIIVRWPVPPVALRPLNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HBK5</accession>
    <name>A0A8J2HBK5_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">ER lumen protein-retaining receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HICCMSTLAB_LOCUS6381</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Endoplasmic reticulum membrane</location>
            <topology evidence="1 11">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the ERD2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5092809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HBK5"/>
    <dbReference type="OrthoDB" id="7694678at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046923">
        <property type="term" value="F:ER retention sequence binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006621">
        <property type="term" value="P:protein retention in ER lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000133">
        <property type="entry name" value="ER_ret_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10585">
        <property type="entry name" value="ER LUMEN PROTEIN RETAINING RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00810">
        <property type="entry name" value="ER_lumen_recept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00660">
        <property type="entry name" value="ERLUMENR"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00951">
        <property type="entry name" value="ER_LUMEN_RECEPTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00952">
        <property type="entry name" value="ER_LUMEN_RECEPTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 11" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10 11 12" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="62"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="92"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="115"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="150"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="178"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAG5092809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="212" mass="24520" checksum="08B40841A7093D1A" modified="2022-05-25" version="1">MNIFRLLGDLSHLLAIIILLLKIWNTRSCAGISGKSQILFAIVYTTRYLDLVTTYISAYNTFMKVIFIGASYATIFLMYAKFKATYDHNHDSFRIEFLILPTIILAVFINHEFTILEILWTFSIYLESVAILPQLFLVSKTGEAESITSHYLFALGSYRGLYIFNWVYRYYAESHYDLIAIIAGVVQTVLYCDFFYLYITKVLKGKKLQLPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HBX6</accession>
    <name>A0A8J2HBX6_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS6829</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5093439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HBX6"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5093439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="126" mass="13797" checksum="B0DDC4EB8AF7FEB2" modified="2022-05-25" version="1">MKKFRTQLSKIANGFIVKTPNQLEPIIVTSMLISGTADTPAKSDFLNFVRFNGAFGCAACCIKGSSGKTNNGSTHIFLAGLKQKKKQYVICPLSPPRIIYLVSTITSTILKGEHHCDDRKKQGNNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HC51</accession>
    <name>A0A8J2HC51_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Similar to Tmem161b: Transmembrane protein 161B (Mus musculus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HICCMSTLAB_LOCUS4902</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM161 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5088584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HC51"/>
    <dbReference type="OrthoDB" id="784140at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019395">
        <property type="entry name" value="Transmembrane_161A/B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13624:SF6">
        <property type="entry name" value="EMEI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13624">
        <property type="entry name" value="RE42071P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10268">
        <property type="entry name" value="Tmemb_161AB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="30"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="85"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="125"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="174"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="224"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="284"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG5088584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="309" mass="34729" checksum="A43BCCEE7E602CCA" modified="2022-05-25" version="1" fragment="single">MLWCILVIGFSLYPFYSIIFFRHYNQRSTCIVMGIVYLLIALAVQIIDEKIIEIGLNKAYTSFNQSATKFLGEHGLSSTGPASGIVLKFSLAVWCGLLGSLLTFPGLRMAQMHSDALIYHKQRKMLSLLANISFASPLLLVCLWIKPISRDYLTVRVFTGASGPLMTPDAFESMRLIAIIVVVLLKLLLMPMYLQSYLNLAEQRLEKLKKESGRITNVDLQKKIAAVFYYLCVVSIQFIAPLLLDNVDNIEKTITQTAEEFHLALGSLKQIFTTEVFRGLFGLATWWTCFTIFATNALGMFCQSYLTAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HCI0</accession>
    <name>A0A8J2HCI0_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS4849</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5088449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HCI0"/>
    <dbReference type="OrthoDB" id="7675350at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="7"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5088449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="278" mass="32455" checksum="B1344DF71EA8EC6F" modified="2022-05-25" version="1">MIPDEDLNKLEETRKNLLNKAIELRDQLKEYLESSRSKNKSVNLNEIVMKQKQIPTENLDEMKNITQIKEMTQTVVGINYRNVSKKWLGDKIWQYKATVEMKELQFKLEVTIDQQEPGVNEILDITCHLKETEIGYLQEISPWVLALTKIKNLSFLMSVFSDYSYQCSLRKKILKKLKNKNIVTIDNGQDERGGLIACLHSSKSADKVYAKFLWRTQLTSRTETIDHIFTIEEIDDGFLEANQQLMKNLCKKPLKKDKLEELWNNLCVAIEEYSASKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HCJ9</accession>
    <name>A0A8J2HCJ9_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Similar to rx2: Retinal homeobox protein Rx2 (Danio rerio)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HICCMSTLAB_LOCUS6863</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 2 3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5093473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HCJ9"/>
    <dbReference type="OrthoDB" id="6159439at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050649">
        <property type="entry name" value="Paired_Homeobox_TFs"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24329">
        <property type="entry name" value="HOMEOBOX PROTEIN ARISTALESS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24329:SF570">
        <property type="entry name" value="HOMEOBRAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 3 6" id="KW-0371">Homeobox</keyword>
    <keyword evidence="2 3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="5">
        <location>
            <begin position="66"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="38"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAG5093473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="116" mass="13361" checksum="ABD4F0A465B5E9EB" modified="2022-05-25" version="1">MAQTCNQKRNVYSIDQILGHAKDEDHANLLESVRNVRGSGDSDIPDFKELPALSDLPEMNDMDRPKKIRRSRTTFTTHQLHQLEKAFEKTQYPDVNYREALASNLELSEARVQVSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HCL3</accession>
    <name>A0A8J2HCL3_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Similar to RF_0381: Putative ankyrin repeat protein RF_0381 (Rickettsia felis (Strain ATCC VR-1525 / URRWXCal2))</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HICCMSTLAB_LOCUS4909</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5088607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HCL3"/>
    <dbReference type="OrthoDB" id="539213at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051165">
        <property type="entry name" value="Multifunctional_ANK_Repeat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24123">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24123:SF134">
        <property type="entry name" value="PFS DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="39"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="395"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="428"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="462"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="495"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="838"/>
            <end position="870"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="871"/>
            <end position="903"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="905"/>
            <end position="937"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="938"/>
            <end position="970"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG5088607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="1219" mass="138385" checksum="7CCB283D5E315282" modified="2022-05-25" version="1">MIVFDVNRPFRNHTTLLCTAVMREILLENNAKINVKKRNGETPLLCAIFNERIDIVKLLMAAGADINAEYSIMRSTLMHDIYSKPWILQYLLSLDEPMTDVNILNKAGQNILHSNSSSRDRAYICVRSSRIILDAGIDVNAQDSEGRLVVIIVKSLLNIISSISSLNNKLSTGLTVCEGNRQAVEIGFDDSSKTRREELQKMKINKVSMTIRLKFAVLDQIINEIKLKTAYPLYGGMLFYKLSKVRRRIKYLEVVEKFVEGILWDLRLPATFIRELCFLNTQHFFIRSLGTFKNLPRKILKFRTRILKNKMLPNLSYKLACMEIPKISSKEINVTVVEKFLNQPGNNVNSIVYDQDRPFPNYTTLLCMAVKKKDEALIDYLIYRQANLDQDSAYGNENPLYLAALKGDTKLFKKLYHLGADINLSSLIRSSPLMIAARCGRLEIIKYLIKQGLDVNVTEPDCGSRLLHHAAASSNTELVEFLLENNAEIDAEKHYGETPLLCAISTEKINNVKLLMARGADINTLRSSNRRSTVMHDVHYRKSILKYLLSLDEPMTDVNILNNAKETILHYKLSSFYSCAETCSIILNAGVDVNARDSKGQLAVNCRTSSKHHTEHVIIERHIVKLISAGLTVCKGNRQAVEKAYDDFRKTCLEEIQKMKIDKVGLTIRLKFAGLDQVINEEKLNIAFPLYGGMIFYKLSKVQRRIKYLEEVEEFVEGILWDLGLPSIFIRELWSYFTNIQLKKLVLINIQNKVMAGVSIGLANTKIPKVRGKKINVTVVEELLNQPDNNVDMIIFDLDAKFYYYTTLLCMAVRNGDEELIDYLINRKADVNKSLPPENENPLLIAAGKGNTEVFKKLYHLGADINLSSSKDLSTLTIAALCGHHGIIKFLIEQGLDVNVTEPDHGFRLLHHAATSSNTELVELLLENNAEIDAKHHNGITPLFYAVTFGRINTVKLLMARGANINNAQGSLSKSTLIHVVHYKKSILKYLLSLDEPVTDVNILNKAGQTILHYKLSTHILNDTGDESCSIILDAGVDVNAQDSKGQLAVNCKTFFRDTTKNTILKRHIVKLISAGLAVCEGNRQAVEIGFDDLRETCLEELQKMKINKVGVSNITFFHVLHMTFHKLAIRLKFAGLDQVINEEKLKTAYPLYGGMLFYKLSKVQRRIKYLEEVEEYFEGILWNLGLPSHFIRELWSYFTNIELKKLILHENNNFIKLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HCZ1</accession>
    <name>A0A8J2HCZ1_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">ATP synthase subunit d, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HICCMSTLAB_LOCUS7291</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the ATPase d subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5093965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HCZ1"/>
    <dbReference type="OrthoDB" id="35799at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015078">
        <property type="term" value="F:proton transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015986">
        <property type="term" value="P:proton motive force-driven ATP synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.280.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008689">
        <property type="entry name" value="ATP_synth_F0_dsu_mt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036228">
        <property type="entry name" value="ATP_synth_F0_dsu_sf_mt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12700">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT D, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05873">
        <property type="entry name" value="Mt_ATP-synt_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005514">
        <property type="entry name" value="ATPase_F0_D_mt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161065">
        <property type="entry name" value="ATP synthase D chain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0138">CF(0)</keyword>
    <keyword evidence="5 10" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="7 10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 10" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="146"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR005514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAG5093965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="172" mass="20086" checksum="2AA700573A610256" modified="2022-05-25" version="1">MATRKAIKAINWSAIAERIQESEKPIFANFRTKSEGYLRRMNEFPETVPAIDWAHYKKSIPNSAMVDEFQKQYSSLSIPIPADKYTSIVEQQEKEAAEHVRNFITESNKRIEEYKAEITKISSMIPFEQMTMEDFAELYPEHAWNPEKPTIWPHDPEYQPGDEPEPIPKGEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HD86</accession>
    <name>A0A8J2HD86_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BEN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS5054</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5088987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HD86"/>
    <dbReference type="OrthoDB" id="6359816at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2590">
        <property type="entry name" value="BEN domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018379">
        <property type="entry name" value="BEN_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10523">
        <property type="entry name" value="BEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51457">
        <property type="entry name" value="BEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BEN" evidence="2">
        <location>
            <begin position="74"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5088987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="143" mass="15546" checksum="BE5BE7E837F75265" modified="2022-05-25" version="1" fragment="single">MNCIFGLIYSGRRARRGRPRLGTKSGRHLASTHGGSPSRNDWLPGPLDMSTTPPTMPAFRGFEESSPDGVVHLGEGIAVCEEQLKAVKWSDYRKLTRGLAAILFSPTELATCSVTGQRWSRAGTATERPVKPALDRAKVQAII</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HD88</accession>
    <name>A0A8J2HD88_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">MULE transposase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS5736</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5090753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HD88"/>
    <dbReference type="OrthoDB" id="8192602at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5090753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="406" mass="46951" checksum="E978AFA4C7AABCF9" modified="2022-05-25" version="1" fragment="single">SYVVEKIRGRKTYVYCEKKNSKSCPVRGVKILNNPIEFPPSVRHTHAYDLLTIDVKSFKNALIATSKKHFYSIDEIYFNVSQSHVDEIKTRLTLKMVKPAMRNHQKKMAASLPMLNTYSEVVEFLTDHISLTKYSAEKLITLRNVGEDALLLGDPGFAALCQFNTLHMSSTINVLPAYGNTRILTFILGQYEHYAFLIGIVLWARQTAEICTEILRQFKFFLLPSINLSKIYVDFDLKIFVKEVFPESNIHGTYNNYCRILYHESYEKNVRIVNASHEEFLKSCFSLILLPHEKIEEGFNELVNNLTHDANVQLTNFIGYFRTTWIQGVGPTNMSLFEETDSLNTVPVLFWTSLQNVMGEKPSLWKFFEKFIIIISKCSKELERIKNKKMHTSLLPYLFAYAAIKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HDB8</accession>
    <name>A0A8J2HDB8_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Similar to twk-9: TWiK family of potassium channels protein 9 (Caenorhabditis elegans)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HICCMSTLAB_LOCUS7797</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5095615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HDB8"/>
    <dbReference type="OrthoDB" id="297496at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015271">
        <property type="term" value="F:outward rectifier potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022841">
        <property type="term" value="F:potassium ion leak channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030322">
        <property type="term" value="P:stabilization of membrane potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003280">
        <property type="entry name" value="2pore_dom_K_chnl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013099">
        <property type="entry name" value="K_chnl_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003:SF257">
        <property type="entry name" value="POTASSIUM CHANNEL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003">
        <property type="entry name" value="POTASSIUM CHANNEL, SUBFAMILY K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07885">
        <property type="entry name" value="Ion_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 10" id="KW-0407">Ion channel</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="7"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="125"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="178"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel" evidence="9">
        <location>
            <begin position="147"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF07885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAG5095615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="309" mass="34587" checksum="82D573E743CD2EA6" modified="2022-05-25" version="1" fragment="single">MWGKIATMGYAALGIPLTLVYLSSAGGLLSRCARGVFTRALCCCLCSNCGYCCYDERRMQEKERRMRKKRQQEEMNQQQQQQLALQEPFYVRANASNYPSSVEIKASPKDEVSSLGSGDRPNVTIFAPISICLGAMLCYIVAGAFTLYFCFMSLSTIGFGDMVPGLYLRHNTVDSKNLTLWFCSCYIMSGMALTAMCFNILHDEIVHRLAHQNDKSESVKPSSSIDELATDPFALTSNNRNTTDESLCNEQPASIFAHENEMNILRDSYNQVDVTRDCKPIIKLEDHIVGSAVYTLPEVDEEAEENTEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HDQ3</accession>
    <name>A0A8J2HDQ3_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Histone H2B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HICCMSTLAB_LOCUS6309</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the histone H2B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5092677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HDQ3"/>
    <dbReference type="OrthoDB" id="1166527at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22910">
        <property type="entry name" value="HFD_H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000016">
        <property type="entry name" value="Histone H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000558">
        <property type="entry name" value="Histone_H2B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23428">
        <property type="entry name" value="HISTONE H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00621">
        <property type="entry name" value="HISTONEH2B"/>
    </dbReference>
    <dbReference type="SMART" id="SM00427">
        <property type="entry name" value="H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0158">Chromosome</keyword>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="12">
        <location>
            <begin position="18"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00017644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAG5092677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="154" mass="16878" checksum="D611F2BD29960BAC" modified="2022-05-25" version="1">MPPKTSGKAVKKSGKAQKNITKSDKKGRKKKRKESYAIYIYKVLKQVHPDTGVSSKAMSIMNSFVNDIFERIAAEASRLAHYNKRSTITSREIQTAVRLLLPGELAKHAVNTSLGDGYSGEKFVQFLIVTDGQLKMTGDDSGLLVVTSSVSSQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HE24</accession>
    <name>A0A8J2HE24_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS6534</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5093030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HE24"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5093030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="71" mass="8411" checksum="A7BC8951127AE43F" modified="2022-05-25" version="1">MALLQFSHYWRNLLWASAWTLQLIPKTSLRLSLKLLALTDHYENHSSWGMPHIYTRIYTSCLRSNGHHCNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HEX3</accession>
    <name>A0A8J2HEX3_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">hydroxymethylbilane synthase</fullName>
            <ecNumber evidence="4">2.5.1.61</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Hydroxymethylbilane synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HICCMSTLAB_LOCUS7112</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>dipyrromethane</name>
            <dbReference type="ChEBI" id="CHEBI:60342"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 2/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the HMBS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.61" evidence="4"/>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5093786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HEX3"/>
    <dbReference type="OrthoDB" id="564646at2759"/>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00319"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004418">
        <property type="term" value="F:hydroxymethylbilane synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd13645">
        <property type="entry name" value="PBP2_HuPBGD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.190.10:FF:000005">
        <property type="entry name" value="Porphobilinogen deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.190.10:FF:000260">
        <property type="entry name" value="Porphobilinogen deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.40">
        <property type="entry name" value="Porphobilinogen deaminase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00260">
        <property type="entry name" value="Porphobil_deam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000860">
        <property type="entry name" value="HemC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022419">
        <property type="entry name" value="Porphobilin_deaminase_cofac_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022417">
        <property type="entry name" value="Porphobilin_deaminase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022418">
        <property type="entry name" value="Porphobilinogen_deaminase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036803">
        <property type="entry name" value="Porphobilinogen_deaminase_C_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00212">
        <property type="entry name" value="hemC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11557">
        <property type="entry name" value="PORPHOBILINOGEN DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11557:SF0">
        <property type="entry name" value="PORPHOBILINOGEN DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01379">
        <property type="entry name" value="Porphobil_deam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03900">
        <property type="entry name" value="Porphobil_deamC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001438">
        <property type="entry name" value="4pyrrol_synth_OHMeBilane_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00151">
        <property type="entry name" value="PORPHBDMNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54782">
        <property type="entry name" value="Porphobilinogen deaminase (hydroxymethylbilane synthase), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00533">
        <property type="entry name" value="PORPHOBILINOGEN_DEAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Porphobilinogen deaminase N-terminal" evidence="8">
        <location>
            <begin position="14"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="Porphobilinogen deaminase C-terminal" evidence="9">
        <location>
            <begin position="241"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004735"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00033064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAG5093786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="365" mass="40302" checksum="9DD1C33F32BB1886" modified="2022-05-25" version="1">MSKHNNENSIVDVIRVGSRKSELALIQTNHVIDCLKDLYPKKKFEIVTMNTKGDKILDISLPKIGEKALFTQELEIALERGHVDFVVHSLKDLPTTLPPGMALGAIMKREDPRDAVVMSKRMSDKTLHTLPSGSVIGTSSLRRSAQLTRSLPHLEVRSIRGNLNTRLKKLDDKDGPFAAIILAIAGLKRMGWENRISELMELPNEEILYAVGQGALGIECRESDWKILSILEPLADVNTTLQCVCERSFLKTLGGGCSAPVAVASSLIDDDLSMIGAVWSLDGETLIKDTLSTKLYHQDDDDNDDEPPKKCSFLEPRLYCSVSPGKMNETSLLGAEKLGKEVANKLIDKNALDVMSRARDEILRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HF17</accession>
    <name>A0A8J2HF17_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Rho GDP-dissociation inhibitor 3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Rho-GDI gamma</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HICCMSTLAB_LOCUS6374</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="4">Inhibits GDP/GTP exchange reaction of RhoB. Interacts specifically with the GDP- and GTP-bound forms of post-translationally processed Rhob and Rhog proteins, both of which show a growth-regulated expression in mammalian cells. Stimulates the release of the GDP-bound but not the GTP-bound RhoB protein. Also inhibits the GDP/GTP exchange of RhoB but shows less ability to inhibit the dissociation of prebound GTP.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Rho GDI family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5092795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HF17"/>
    <dbReference type="OrthoDB" id="413572at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045505">
        <property type="term" value="F:dynein intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005094">
        <property type="term" value="F:Rho GDP-dissociation inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003341">
        <property type="term" value="P:cilium movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036159">
        <property type="term" value="P:inner dynein arm assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036158">
        <property type="term" value="P:outer dynein arm assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007266">
        <property type="term" value="P:Rho protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.50.30:FF:000001">
        <property type="entry name" value="Rho GDP-dissociation inhibitor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.50.30">
        <property type="entry name" value="Coagulation Factor XIII, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052623">
        <property type="entry name" value="DAAF5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056497">
        <property type="entry name" value="HEAT_DAAF5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000406">
        <property type="entry name" value="Rho_GDI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024792">
        <property type="entry name" value="RhoGDI_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057978">
        <property type="entry name" value="TPR_DAAF5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16216">
        <property type="entry name" value="DYNEIN ASSEMBLY FACTOR 5, AXONEMAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16216:SF2">
        <property type="entry name" value="DYNEIN AXONEMAL ASSEMBLY FACTOR 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24573">
        <property type="entry name" value="HEAT_DAAF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02115">
        <property type="entry name" value="Rho_GDI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25757">
        <property type="entry name" value="TPR_DNAAF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00492">
        <property type="entry name" value="RHOGDI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dynein axonemal assembly factor 5 TPR repeats" evidence="9">
        <location>
            <begin position="16"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="domain" description="Dynein axonemal assembly factor 5 HEAT-repeat" evidence="8">
        <location>
            <begin position="311"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="851"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="851"/>
            <end position="864"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009758"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00053735"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00073845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00080671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF24573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF25757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAG5092795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="1052" mass="120556" checksum="CFE6240D4103A937" modified="2022-05-25" version="1">MSRIENLQLSEICVSLQSDDKKRRFLVLKKLHDILIDEDNQWSKREVLEIWQIMNKHIVKVLIDPTESCRESAVEIIKIFITSLPIIEKNIMYIIPIFVRRLGSQELLEPSEEVRLNCISLLRLIICFYKDHLSVYIDDFVQILSKTVTDNYPKVKRETCEAISELAKTIPVQFYSKSELLVKPILSNFTHQHYRVRVSSVKAIGDVIQHGNSKSMEEVSTPLAERLFDQSGAVRIVVIEVAGYWFSNLRDRYSWWYKLIPLLVTGLHDEILEIRLKAQNLWDAAGALFLKENESDEKIKNKMDFLAEDLDHYPPNIKRPNLGCRLIVQQNIGKLIGGIVKELGDWKADIRVRSAQLLAVLTLNAEQDITQHIEKLLPAMYRACNDQDIRVVDNIILAAEYIGYFVPPETYCQLVLPTLEDGNITAGHLAVLAAILRGSERRSLLNKLDDIGSFLQLSHICRSKKADYQQQILRCCEAVINVSKEDCNIIANNLFTTIFTVWSMSHQEPQQIFAKQLMEKLVVETMSESLQELFSLNLREILLNIKDSSKSWTGYSPEVYIFRLCLTEAKSTSAENMDIVLTILKDTMTKDADAELRLKFFILLSDFFQHRNETLKLIKDPTEFITDFFDNILMPGLIWSAGKASEAVRTAAVGCLCALFDDSISEDENKPKLRFDDLENGCTELIVNDKNFIPIFVKVLPILMSLIEDNAKKTRLYALRALYLIIKIGLKISCITDNDVIKIYPALVKRLDDGCDDIRYGAVEALVFVWRALSKDYDLDFGKSHIDYLYTTTIVHLDDPEVEFQNMMLDAMMSLAKIHPELLANKIIKCKNNFKNQAALDKLLQHCHDMADSSGDHADDRREEELEVESNYKPPPEKTIEQILEADKDDESLRKYKETLLGEAKSGGIVVDSTDPRKVIVKKLALCVAGRADMELDLSKDLTQLKKQTFVIKEGVSYRIRIDFIVQREIVHGLKYIQKTYRLGVPVDKMTHMVGSYPPKTEIQSYTTPAEDAPAGVMARGSYTVSSLFTDDDKHEHLKWEWSFDIKKDWKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HFK9</accession>
    <name>A0A8J2HFK9_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS7188</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5093862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HFK9"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5093862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="120" mass="13793" checksum="4BFA9F7290D1F0D9" modified="2022-05-25" version="1">MTLLKRGRQRGSRIKDLKAERERPLRLWVAGACTRGRGRGRTQARARKRRRTSLRSRSLKEGVRGAIDSSFNLVVSIKTRFIKGSEYVSIKCGKRNKRNAIKLHRVFSVIRGLFRAISSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HFU9</accession>
    <name>A0A8J2HFU9_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS9386</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5100104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HFU9"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5100104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="169" mass="19516" checksum="F68D067B8F91B31D" modified="2022-05-25" version="1">MIKGRNTIIRVCDGQISNKYTQKTMLKGRNTIIRVCDGQISNKYTQKTMLKGRNTIIRVCDGQISNKYTQKTMLKGRNTIIRVCDGQISNKYTQKTMLKGRNTIIRVCDGQISNKYTQKTMLKGRNTIIRVCDGQISNKYTQKTMLKGRNTIIRVCVGLKYEFNFSLRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HFV2</accession>
    <name>A0A8J2HFV2_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Dipeptidase</fullName>
            <ecNumber evidence="1">3.4.13.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS9123</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>an L-aminoacyl-L-amino acid + H2O = 2 an L-alpha-amino acid</text>
            <dbReference type="Rhea" id="RHEA:48940"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:59869"/>
            <dbReference type="ChEBI" id="CHEBI:77460"/>
            <dbReference type="EC" id="3.4.13.19"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer; disulfide-linked.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the metallo-dependent hydrolases superfamily. Peptidase M19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.13.19" evidence="1"/>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5099566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HFV2"/>
    <dbReference type="OrthoDB" id="445695at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070573">
        <property type="term" value="F:metallodipeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008257">
        <property type="entry name" value="Pept_M19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10443:SF45">
        <property type="entry name" value="DIPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10443">
        <property type="entry name" value="MICROSOMAL DIPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01244">
        <property type="entry name" value="Peptidase_M19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51365">
        <property type="entry name" value="RENAL_DIPEPTIDASE_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0224">Dipeptidase</keyword>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="1" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU341113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5099566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="314" mass="35360" checksum="E8066229CCEBEA85" modified="2022-05-25" version="1" fragment="single">MVYISIGVFSIVILVLVIGLSVGLRATPFKGSDVLNFAPLVDGHNDLPWNLYDKLANNLSALNFDTDLSNDPFMGYKDAIQLTLRQIDMIKRLVNKYPSKLEFVTNSYDIERVWKNNKIASMIGIESGHAIDSSLAVLRLYHELGVRYITLTHNCNTPWADASIKKNNGVVMVNFYNLFVNCNRSRDTTIEDVVAHINYIRNLIGPDHVGIGSDYDGVDETPKDLEDVSKYPKLFDRLYESREGEPTWTRADLEKLAGRNLIRVFEDVEKVRDSLKSELASDMTIDGHDLEIAMKNEGLTPGACQTANEWKGIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HGF8</accession>
    <name>A0A8J2HGF8_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS9501</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5100333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HGF8"/>
    <dbReference type="OrthoDB" id="7669346at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5100333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="311" mass="36537" checksum="FB6711E4156AD95C" modified="2022-05-25" version="1">MCESFIRLKDKERLKTVHGDSQVYGPNTPIYHIEPDRTGKYITVRRQDNVLTSHGSKYSKGDALQPKMLLVYDYWDFITYGQEKCIEKAKKTVKFINSYYEELKSNPKIEVVLTGIAFITERQVYTRPSVFQVTEADFLKSHLLTEKYIIDDQLQTGDWRDFSLASKEVQRFSEWLSNNKDQFERLNYDFFLYSFPWYMADDATPDLQKHLVMSLSERKLCSANPGLLVNNLIGDEHPAYPVEISYLLGTTHPLDRHDSHYFTSNFEFFDDVKEKWQQRTISVISNNSGNNAYFCIKDTTPDYDEYEDNNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HGH5</accession>
    <name>A0A8J2HGH5_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Similar to TRDMT1: tRNA (Cytosine(38)-C(5))-methyltransferase (Homo sapiens)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HICCMSTLAB_LOCUS7239</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="4 5">Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5093913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HGH5"/>
    <dbReference type="OrthoDB" id="414133at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.120.10">
        <property type="entry name" value="DNA Methylase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050750">
        <property type="entry name" value="C5-MTase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001525">
        <property type="entry name" value="C5_MeTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00675">
        <property type="entry name" value="dcm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46098">
        <property type="entry name" value="TRNA (CYTOSINE(38)-C(5))-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46098:SF1">
        <property type="entry name" value="TRNA (CYTOSINE(38)-C(5))-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00145">
        <property type="entry name" value="DNA_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00105">
        <property type="entry name" value="C5METTRFRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51679">
        <property type="entry name" value="SAM_MT_C5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="active site" evidence="4">
        <location>
            <position position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAG5093913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="343" mass="39388" checksum="C20B92370E67A138" modified="2022-05-25" version="1">MRVLELYSGIGGMHYAFEIANEVYKHNFPSTKLINRNIGSLTVKDIEDLKIDSIFMSPPCQPFTRNGLQKDIEDARTISFFHILELIPQLKNLKYILLENVEPFSKSVSRDILISCLQNIGFNYRECILSPSDFGVPNSRSRYFLIAKKNDLPFCLSKYSSDITADLILELLPKSQRFKTFKNKHPEYLTNDCIKLSEIVSNSNDIDTQEYNLPESILNKYVKVLDIRSPDSKGSCCFTSAYGRYAEGTGSVFSPLLSSDVEEKIYELKNNEQLINYLDIIKSLRLRYFTPSEVSRLMCFPDKFTFPSTISKRQRYKLIGNSINVHIVSLLIILLDYVPDSNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HHA7</accession>
    <name>A0A8J2HHA7_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Similar to Prx: Periaxin (Rattus norvegicus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HICCMSTLAB_LOCUS10278</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5101205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HHA7"/>
    <dbReference type="OrthoDB" id="447516at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00136">
        <property type="entry name" value="PDZ_canonical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051342">
        <property type="entry name" value="PDZ_scaffold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19964">
        <property type="entry name" value="MULTIPLE PDZ DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19964:SF97">
        <property type="entry name" value="PDZ DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035160705" evidence="2">
        <location>
            <begin position="25"/>
            <end position="1103"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="3">
        <location>
            <begin position="112"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="249"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="406"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="874"/>
            <end position="960"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1000"/>
            <end position="1037"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="249"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="268"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="441"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="478"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="521"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="534"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="562"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="882"/>
            <end position="891"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="895"/>
            <end position="909"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="915"/>
            <end position="933"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="949"/>
            <end position="959"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1017"/>
            <end position="1031"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG5101205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="1103" mass="123126" checksum="4E61F5EE4BABF5F7" modified="2022-05-25" version="1" fragment="single">LHYIKSHLLLRILFYLQLFLSFSGNHLVLVTDPEIVEDAYAFDNPCFKDATPAQNRQIDRPLSIISTETPTKDSMKWSSPWSSLGLGSGNKFDKRKTLDDSCLGANATRISVISLRSRDFTGLGFNVCGNMREGIFVKDLLHRGPASESGRIHPGDRIASVKISFRSMVYEDALTILSYASPYDVELEVESGGSSSRPTTLLKKTVGPTPSRICHPLYRSQSIPELSKVDKNSAKRLFIADPNESLGSNYSTMNSTLKSSKSTPGSHTLERRHEESKGNNNHFKFGIKVLPVLDNTVYRIENQNEHNTNLERHNSRKTDAEKNIINSKNLNSVDTKPVKDGKVTERIQQRENTGLKGGESFDAIDSKLTNQSDKSTELVDIPSEVPAEVHNAAIAARRNRKNSAELLKSPKIITSPEFPGDFEEKSPQKSKRKAPAPPESPMKETPGKYESLKHEREDIDDKIESITDYTESLNEYVVKVRDTGERHSRLKERSSERRSSESDTDNETQDSFTTIELNPADITIHHTPIPHIVDDDDDDDDDPDDGYRKAASLGDLSKYEAKSSSTLERAQSLDMTDTSLRKRKTPLPPEDITEVTEDLTKLDEIDTFDRRKLKKSSEWGTLEDAIWNKDSDDISVEIISKPKIRKKSSGTLERSKSAVEIKLKEGMTSFNQVDNKNEDCSIELYNLPLSKSLTRDFIAAERSFNPDEDNSLARIVNNGETIKNPSLDEIELDFRQAKPFMGELEEDIAVIDENDSEEMVINLPVSESFGKALRFFDLHASEEKNDLGKKTNGDVDVSSMYAGLKEVTEEPMRKKIVNRRCPYCNGDELHDKSCSLHSRLVSGDTDSGDSLSNRIGDEEKYYKAIEDQIEKRMTGKMNKVDNEEEEIDDGCDIGSSVTINSNSKSQSPGNDRHNVSNVSNVSVSSGENSEDSGLVGESGEFNQIDAKPTVSSVPIGTQDSPRKMTYITEIKVSPSREIIREPEDVESNRDIPALKGEVTVTSNGKSIPGRKPPVPPRRSDASKALKDKANDKQVVYVSEYKSPNKNIIEDKLDSNSTTGSKKIDHWIYLGDNKEQNPWGNGSSQPQSVTNIVVASGDEKIFHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HHY6</accession>
    <name>A0A8J2HHY6_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Similar to CycE: G1/S-specific cyclin-E (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HICCMSTLAB_LOCUS8039</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the cyclin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5096097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HHY6"/>
    <dbReference type="OrthoDB" id="5590282at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd20519">
        <property type="entry name" value="CYCLIN_CCNE_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20520">
        <property type="entry name" value="CYCLIN_CCNE_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000001">
        <property type="entry name" value="G2/mitotic-specific cyclin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039361">
        <property type="entry name" value="Cyclin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004367">
        <property type="entry name" value="Cyclin_C-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048258">
        <property type="entry name" value="Cyclins_cyclin-box"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10177">
        <property type="entry name" value="CYCLINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02984">
        <property type="entry name" value="Cyclin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01332">
        <property type="entry name" value="Cyclin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00292">
        <property type="entry name" value="CYCLINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1" id="KW-0132">Cell division</keyword>
    <keyword evidence="2 4" id="KW-0195">Cyclin</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin-like" evidence="6">
        <location>
            <begin position="157"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin C-terminal" evidence="7">
        <location>
            <begin position="251"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="70"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="416"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="70"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="416"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="447"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG5096097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="457" mass="51493" checksum="B956CC4CBBA639B2" modified="2022-05-25" version="1">MPQASFQEKNSFQSCPLSSKSQTLKRKRKNTEPSEDAENIYPPTKQQLTVSPSTCLETCNDVYTIEEVKTPQHQISEETERREPSTWSELRTSTCFMTPSTSTAGKHNPLPTFPWADGTQVWSMLCLGDQKALTQRDPQMFERHPTLEPRMRAILLDWLIEVCEVYKLHRETYYLGMDYVDRYLSTHQNIPKSQLQLIGITCLFIAAKVEEIYPPKIAEFAYVTDGACAEDEILRKELVILKGLGWNLSPVTPTGWLNVYMQLESGDWERPNAFIYPQYSGLQYSQAAQLLDLSTLDGGSLKFPYSHMAAAAVYYTLGRECALRVSRLTWEQLSPCVKWMAPFASTVTEEGSQLLLRSVVVPPVETHAGSGLRATVPNIVLDESHRLQTHVVDLSMLEKAQQLYESNELSLVESFDQNSSLGTPESPDQSGILTPPSSSQKNSPTPSRLPPQLEPYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HIG6</accession>
    <name>A0A8J2HIG6_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similar to Nmt1: Glycylpeptide N-tetradecanoyltransferase 1 (Rattus norvegicus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS6082</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5092356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HIG6"/>
    <dbReference type="OrthoDB" id="60315at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="49"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5092356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="129" mass="14809" checksum="F08253BB10AC9D13" modified="2022-05-25" version="1">MEDKNRDSDRENKKEDNHDKNAKSKSSKKRDRKKKNQTANSGENNQIISPTMTSSEMTSTNASGEVPGACFSIKEIQMAMEVLKMQHKPAKTQEEALQKTYQFWSTQPVPKMEFYRSAKTPVYRTSTKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HIR2</accession>
    <name>A0A8J2HIR2_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="3">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">HICCMSTLAB_LOCUS11043</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="3"/>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5102494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HIR2"/>
    <dbReference type="OrthoDB" id="426657at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031491">
        <property type="term" value="F:nucleosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006302">
        <property type="term" value="P:double-strand break repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22249">
        <property type="entry name" value="UDM1_RNF168_RNF169-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051657">
        <property type="entry name" value="RNF168/RNF169_E3_ubiq-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018957">
        <property type="entry name" value="Znf_C3HC4_RING-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23328">
        <property type="entry name" value="RING-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23328:SF0">
        <property type="entry name" value="RING-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00097">
        <property type="entry name" value="zf-C3HC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="13">
        <location>
            <begin position="33"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="500"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="809"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="500"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="555"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="573"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="590"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="636"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="668"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="685"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="697"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="812"/>
            <end position="821"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CAG5102494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="872" mass="98522" checksum="4277C30ABC6EABDC" modified="2022-05-25" version="1">MATYLKRTSKLYDLTVTHAASADNNINFSDLLCPVCRGILIEPVTLPCDHNLCLRCLKGALKHNSLSCPMCRVRVGSWLRTATKSETLVNNNLWEFIRSNYPKEIQDKTNVIINDVPHINNQPDYTQNLLSSGGEIHCGYELQLKLAEQEMLRQRESERLVNEQYLRKLHEPEQDDKQKLTQYAQDRLLARTLAKTQLLDKEKTIKYYNECLKNTTHQPNKYLVPQSGDCLQNELLQFNNNNNNNNKQLLLPASDPLQLNSHLFNLSSINIKTGPGNLLSRNIDNDIRMSSNINLMATKLQPIDTRQSFSSCLSKPSSIVRTKDCCQLTPSSSLSSTLLIPNILTLKQQTMPKMNAYITTEPGCSNSTLNLNLNSNSKIYGDQNEEELRVPADLLSNNKKNLAMEICVMTTGIVDDKQQRVSAQSAGSHDSINPEIHHFKPIKILPRTPLKLMPDGRQIDPKIVRVVPVLKRIGNPIFRAPSVGHFRRIGRIRQEARIINTSPTWKSPRNSAELNQNQSKIQSLSQASTESNSPKQNLPTETTEVNKNNHLINGTTAAITSPPTLTSTSTKSAKTKSKSSKNGALKRNKNKPDLLPDDKPAPLEDSQQKANEVPITDDNESQAMENIAERIKRRKVNQEPKTTYKIEDDDGEDCNGGKIKSRTRKSSRKVETGKPETEDTDKKIKTPKKVTRKRGERLKVLKFEDSPDLEDKSLDSEKLTRKRTTRSSARKCKNKLLSYNGDDIDIDIDIDNDNDNDNNNKVNGVHGDDNDDERVIVEEENIERLSQQEKQDYELARRLQAEFNEMELGISRRTRGSKRTPKSSDDSIPLSARALEIRKKKRGNVNVNGKLIANATNAKPITPAIKSRRKRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HJF6</accession>
    <name>A0A8J2HJF6_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Similar to Sqstm1: Sequestosome-1 (Rattus norvegicus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HICCMSTLAB_LOCUS10025</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5100952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HJF6"/>
    <dbReference type="OrthoDB" id="441278at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016235">
        <property type="term" value="C:aggresome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044753">
        <property type="term" value="C:amphisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070530">
        <property type="term" value="F:K63-linked polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005080">
        <property type="term" value="F:protein kinase C binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035973">
        <property type="term" value="P:aggrephagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007032">
        <property type="term" value="P:endosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000423">
        <property type="term" value="P:mitophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14320">
        <property type="entry name" value="UBA_SQSTM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02340">
        <property type="entry name" value="ZZ_NBR1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.10:FF:000034">
        <property type="entry name" value="Sequestosome 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052260">
        <property type="entry name" value="Autophagy_Rcpt_SigReg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033741">
        <property type="entry name" value="SQSTM_UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000433">
        <property type="entry name" value="Znf_ZZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043145">
        <property type="entry name" value="Znf_ZZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15090">
        <property type="entry name" value="SEQUESTOSOME 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15090:SF0">
        <property type="entry name" value="SEQUESTOSOME-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16577">
        <property type="entry name" value="UBA_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00569">
        <property type="entry name" value="ZZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00165">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00291">
        <property type="entry name" value="ZnF_ZZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54277">
        <property type="entry name" value="CAD &amp; PB1 domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01357">
        <property type="entry name" value="ZF_ZZ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50135">
        <property type="entry name" value="ZF_ZZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="ZZ-type" evidence="10">
        <location>
            <begin position="100"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="250"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="322"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="250"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="322"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="350"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAG5100952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="436" mass="47849" checksum="12D397D9A5D4F11D" modified="2022-05-25" version="1">MATVSFKVYLHHEADASYQEIRRFGIDSDVVTNYIYLREKLQNIFPNIRDSDGDDVVISSDEELQIALNETGLESVRKLYVKLRSDYSPEPESDSSSILHPGISCDGCNGVVRGYRFKCVQCPDYDLCSKCHGHGIHSDHCMLRIVTPVDWKAHHGRRLSRHMNKFVRKNFIPVDECEEPAGICGNTGDSSKKCPRSQRRRHCPVSDAASAAASAAASAAAAAAVTDAGGWIDSLAAYLNDWANIPAECPMKKPGFDKPAEAQEAKEQPKEKQQEQQQQSKSQDARKDPHIELFKLVGQNLSQFLDPLGIDVNFQLKTNDAPASTSGATKTNEQPQAAGPSAKNSDKSKTSSPTPATPTNSATPSRPKTPEQVSAEKSKLPKATPTPVFYHSDPKIQKAVEAMIQMGFSNESGWLTNLLVTKEGDIVRALDALQRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HJV5</accession>
    <name>A0A8J2HJV5_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS10096</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5101023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HJV5"/>
    <dbReference type="OrthoDB" id="8583677at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="579"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="175"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="646"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="38"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5101023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="737" mass="82230" checksum="16EC173D6226A68F" modified="2022-05-25" version="1" fragment="single">TRELTLVETLDNVKCPSTSWNREEVVSNHLIFSDSCANKSQSNPKSNSRNNNNNNNLTNNYLKISTGFNVDEDDGTNRARSGAISRKFDETWVDAEKHSTPSKESISYISRKNPSCSVQKSGICNTDNNLIIPQNLSLPNEQKDNLVTVSSKKEDTIANYNTDNRLLLINASYSSHKGGTSSQEREHRQEFSPGLQGYSTSQLQSSQCIKLIPDRSKLLEQDYEKRVSRSRSISTDDVDDLINSNDNFGTSNDNNNYCYSSSSSPSNLKLLKNNRKVKSDLDLSYRRSHLNSNLRLKLKRSPSPENNALYSSSGSAEYSDIILRSSDNSVNELRCLNWSNSTTLHSSVSSGYSFSNVSDGEKDIIGDSYYDGYSNTTNSSGSINDNEQKGGKKALKGSEDNLLTEKKEGEKVERKSSVNPCANKIIQAEQQVIHSQETKTKFDDYWLEDNDHLDEESACCSCSCDSYTNYCSRRWSEYSIQASNSNPVGLVSESNLTVIESRNLLSDGPEEENESEIKGRIGKQLTLKQSQRRLTVSRESYTLANRLEDRSSNLKSQVDNNKDPNMKILIKIMRIREKIIYGFSAFAILFTLLLVMDLQMDLGYSGHHLVPSHGRVRMHDELGHDTVYTNFHRKFLQRVNASKELTASDNSIGGGPNSRDNTANNGGSVVASADAAAPGNIIRDNTKREPLHDDFGDLVDILVNADNIDLDTGVVRISNEDYSDNPTIGDIRGIPIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HKB0</accession>
    <name>A0A8J2HKB0_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS10155</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5101082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HKB0"/>
    <dbReference type="OrthoDB" id="10474472at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5101082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="172" mass="19789" checksum="969680C705BEC12F" modified="2022-05-25" version="1">MLKSGDADKIYLVNKGAINIRHKIEKEDVYYNEKLEKTFDSNYRRIATLISRKPITEDYISLYKNINEIDTNKCFTSDGNDLLNLSPCLNMNFTGIMNSNIHDPAFFCSWLEHDSIKSNVVVCDAKMSLRKIFLGILSLHRSSDDYGEWIGVENVADLEEKINEKLKNLSVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HKM5</accession>
    <name>A0A8J2HKM5_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Similar to CG11722: Protein NDUFAF4 homolog (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS12149</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5106215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HKM5"/>
    <dbReference type="OrthoDB" id="2434756at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032981">
        <property type="term" value="P:mitochondrial respiratory chain complex I assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009622">
        <property type="entry name" value="NDUFAF4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13338:SF4">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX ASSEMBLY FACTOR 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13338">
        <property type="entry name" value="UPF0240 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06784">
        <property type="entry name" value="UPF0240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5106215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="188" mass="22039" checksum="F8D6410AD6E58479" modified="2022-05-25" version="1">MSKIMGVIMSRLSKPAKAFNIENRAAKILEREKPIPAPPHPSTAQQLKISREVDPNFLENHYKKDEELYDRLKQVFVSSHIEHKIIDQESEAKKPKNKKWSQDFEYGFWEPEKIPEGRCQLKTALQFMADYQADSKKNSIESIAMKYKLDPADVKNIIKYYRVFQVVQPKDSKMFVPREDAKPLIEEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HLM6</accession>
    <name>A0A8J2HLM6_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Peroxisomal leader peptide-processing protease</fullName>
            <ecNumber evidence="1">3.4.21.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS8259</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Peroxisomal protease that mediates both the removal of the leader peptide from proteins containing a PTS2 target sequence and processes several PTS1-containing proteins. Catalyzes the processing of PTS1-proteins involved in the peroxisomal beta-oxidation of fatty acids.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="1">The full-lengh TYSND1 is the active the proteolytic processing of PTS1- and PTS2-proteins and in self-cleavage, and intermolecular self-cleavage of TYSND1 down-regulates its protease activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S1B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.-" evidence="1"/>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5096537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HLM6"/>
    <dbReference type="OrthoDB" id="17845at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031998">
        <property type="term" value="P:regulation of fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039245">
        <property type="entry name" value="TYSND1/DEG15"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21004:SF0">
        <property type="entry name" value="PEROXISOMAL LEADER PEPTIDE-PROCESSING PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21004">
        <property type="entry name" value="SERINE PROTEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13365">
        <property type="entry name" value="Trypsin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="1 2" id="KW-0645">Protease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0720">Serine protease</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR037989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5096537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="513" mass="56832" checksum="CC1AB0CE051F5399" modified="2022-05-25" version="1">MASKGVAISLVEQNGKEIEYTSGIHILKNWVLTHGILLKPKIEKDKKFSDFISTLPPGEIVNLSGRENHLKVQVKLCRKISKSSTQNTEVKSLNGVVVSLWSCPLLIDFLTKLYSSTDLSETFDRLNRILLPIILVIYLNEKDENVNNVNECSVENVHKMLDYFCDSQLSQQIPEKGDDVEIESTPFGNPVFINSISKGIVSNVLGIDKCVMLTDIHAIPGCEGGLVYSTNGKDGSRVIYGMVIAPLSLCRSEWVNYTFVACLLPCLKRLLRKQEDKKTLKINQENFNIIDSLNKCVVLIYCGSEWGSGILLDRGTGTILTCSHVIDKAPNRRIKVGFSRKNLSSQSMKIQWAELIYRTPKGVPYDIAILKVDPNEINSAIKPLKIGNSLVLRGESVISAGYPFLCSNLPTITHGNISNVSSCMLQTTCYVQSGNSGGPIIRPTTGELLGITVCNVITSTTRYPRLNMGVPATVLIDPINEYIKTNRVQALDTLMSYDENVVRTWNCLLPSKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HMQ3</accession>
    <name>A0A8J2HMQ3_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Similar to PRKX: cAMP-dependent protein kinase catalytic subunit PRKX (Homo sapiens)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HICCMSTLAB_LOCUS12143</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5106203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HMQ3"/>
    <dbReference type="OrthoDB" id="63267at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005952">
        <property type="term" value="C:cAMP-dependent protein kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004691">
        <property type="term" value="F:cAMP-dependent protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24353:SF37">
        <property type="entry name" value="CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24353">
        <property type="entry name" value="CYCLIC NUCLEOTIDE-DEPENDENT PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="7">
        <location>
            <begin position="68"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="85"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG5106203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="122" mass="14312" checksum="EE473E1DCF742CD0" modified="2022-05-25" version="1">MLAGYPPFFDDNPFGIYEKILSGRIEWPKHVDPIAKDLIKKLLIADRTKRLGNMRQGAEDVKRHRWFKLIDWQLVPQRALTPPIRPRVKAPEDASCFDDYPETDWRSQPPLPPDQLALFQDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HNC9</accession>
    <name>A0A8J2HNC9_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ER membrane protein complex subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">HICCMSTLAB_LOCUS12697</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subunit">
        <text evidence="3">Component of the ER membrane protein complex (EMC).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EMC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5107334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HNC9"/>
    <dbReference type="OrthoDB" id="28092at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072546">
        <property type="term" value="C:EMC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034975">
        <property type="term" value="P:protein folding in endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058545">
        <property type="entry name" value="Beta-prop_EMC1_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026895">
        <property type="entry name" value="EMC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011678">
        <property type="entry name" value="EMC1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21573">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21573:SF0">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25293">
        <property type="entry name" value="Beta-prop_EMC1_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07774">
        <property type="entry name" value="EMC1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="910"/>
            <end position="929"/>
        </location>
    </feature>
    <feature type="domain" description="EMC1 first beta-propeller" evidence="13">
        <location>
            <begin position="38"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="EMC1 first beta-propeller" evidence="13">
        <location>
            <begin position="186"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="domain" description="ER membrane protein complex subunit 1 C-terminal" evidence="12">
        <location>
            <begin position="739"/>
            <end position="942"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF07774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF25293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CAG5107334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="943" mass="105496" checksum="A25894F1BC15F154" modified="2022-05-25" version="1">MAPSMPNFRININRFINDSLLFQYLIILFGVFNLSLCLYEDQVGKFDWRQNYVGEIKFSSFDTVSAAAKLIVATEENVVAALNLKSGQILWRRVLERGYAGKIHALGGISDGELISVSGGVPVIVRVWDLATGHILNEWPLAEQNPERLDTPFISFSTFGLYSTERLEDVKWHLKDGTLHHILPIYSSGVEVTSYDSKTGEKLDTRKVSAPFITPETECILAAPYLGCLKGNTFDDSLAILFLVHLFDNNSQPQSITINNIFGAGAKGPFHVKSIPGDESVLTIIADGDNRQRILIPGNPANTIPRDIPANANLYVTTIDNEKVLLETTYKNGVTEIKAVKLLTSELLEDYSATTSHESLFSPIIKASVCPKLSKGIMCRHLLSSEDHSVALLQHNKLIWTREEALASIITVEMVELPMSDRDQTLETEFDQKERDVIGMFTRRLTAQMNQVRSLFQTTFDINLPQSNQRADLVRDKFGLHKMIVVVTSAGKLFGIESKKGEVIWQLRVNDITSLKSDANTMLLFVQRGSRHFPHPPQCALLALDKKSGEGVIYTFNPITGQPIDGLVKLGYKLKQSMLLHITTDDFLRPILLLDTRDKVHVFPENATAVAASVGKNTYLFTGDQETGVLSGFSLAYSTSKELVAHKVWELVLSPKNQKITHIVSKNSLEHVHSQGRVLGDRSVLYKYINPNLVAILTQGVGNSYKNTLNLYLLDVVSGAMIFSITHKRVRGPFHIVHSENWLIYSYYNDKSRRIEIATLELYEGKVQSNTTVFSSLTTTRLPLVERQAFIFPATIESMQETITEKGITSKHILVSLANGGILELPWMLVDPRRPINPELREEGVIPYMPEIPIHMDAIINYNQSVFRVSGIHTSPSGLESTSLVFAHGIDLFYTRVAPSKTFDVLKEDFDYYLIILVLSGLLIASYITKKLASQKAQKQAWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HNW8</accession>
    <name>A0A8J2HNW8_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS11357</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5103133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HNW8"/>
    <dbReference type="OrthoDB" id="10532808at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035222828" evidence="1">
        <location>
            <begin position="22"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5103133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="92" mass="10237" checksum="0C8C913947B2FC4E" modified="2022-05-25" version="1">MARWCIFLLIASIFIISLTQSVPIQEEAGSVNKIEDSIKKALETISKGFEDMIKNPKVNELIKDGQKMMEEAAEKIKTETAKLLPKTDGAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HP31</accession>
    <name>A0A8J2HP31_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS11355</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5103129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HP31"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5103129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="103" mass="12075" checksum="BF032D43B5B0331A" modified="2022-05-25" version="1">MSTIQYHKCAESYVDSYCVLKLGSRDMIRFFISFTGREFLNPSIEHTHLWNINCSFMVADSYRMSVRQLSKLFFQPEASVDNFGKEFQKELNRLDKNTASNTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HPC2</accession>
    <name>A0A8J2HPC2_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">furin</fullName>
            <ecNumber evidence="14">3.4.21.75</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">HICCMSTLAB_LOCUS10304</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>Release of mature proteins from their proproteins by cleavage of -Arg-Xaa-Yaa-Arg-|-Zaa- bonds, where Xaa can be any amino acid and Yaa is Arg or Lys. Releases albumin, complement component C3 and von Willebrand factor from their respective precursors.</text>
            <dbReference type="EC" id="3.4.21.75"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Golgi apparatus membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase S8 family. Furin subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.75" evidence="14"/>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5101231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HPC2"/>
    <dbReference type="OrthoDB" id="300641at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016486">
        <property type="term" value="P:peptide hormone processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04059">
        <property type="entry name" value="Peptidases_S8_Protein_convertases_Kexins_Furin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.200:FF:000001">
        <property type="entry name" value="Furin 2, isoform B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.260:FF:000006">
        <property type="entry name" value="Proprotein convertase subtilisin/kexin type 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.850">
        <property type="entry name" value="Peptidase S8, pro-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034182">
        <property type="entry name" value="Kexin/furin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002884">
        <property type="entry name" value="P_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023827">
        <property type="entry name" value="Peptidase_S8_Asp-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022398">
        <property type="entry name" value="Peptidase_S8_His-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032815">
        <property type="entry name" value="S8_pro-domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038466">
        <property type="entry name" value="S8_pro-domain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42884:SF3">
        <property type="entry name" value="FURIN-LIKE PROTEASE 1, ISOFORMS 1_1-X_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42884">
        <property type="entry name" value="PROPROTEIN CONVERTASE SUBTILISIN/KEXIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01483">
        <property type="entry name" value="P_proprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16470">
        <property type="entry name" value="S8_pro-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51829">
        <property type="entry name" value="P_HOMO_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51892">
        <property type="entry name" value="SUBTILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00136">
        <property type="entry name" value="SUBTILASE_ASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00137">
        <property type="entry name" value="SUBTILASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0165">Cleavage on pair of basic residues</keyword>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7 16 17" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 16 17" id="KW-0645">Protease</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 16 17" id="KW-0720">Serine protease</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="10" id="KW-0865">Zymogen</keyword>
    <feature type="domain" description="P/Homo B" evidence="19">
        <location>
            <begin position="399"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="607"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="814"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="18">
        <location>
            <begin position="612"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="624"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="655"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="820"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="15 16">
        <location>
            <position position="109"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="15 16">
        <location>
            <position position="150"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="15 16">
        <location>
            <position position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00035756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00038993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR615500-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU003355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="CAG5101231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="895" mass="98481" checksum="A1D0B2A5B2741D8E" modified="2022-05-25" version="1">MFFLLQLFDDVYHFDQKLVAKRSAEPHLEMHRRLAGDPRVQNAKQQRILSRRKRDFVVKRGPASSRAILNDDRWPQMWYLNRGKGLDMNVQGAWADGITGHGVVVTILDDGLEKDHPDIYSNYDPQASYDVNSYDDDPMPRYDYLNSNRHGTRCAGEVAATANNSFCAVGVAYGAGVGGVRMLDGEVTDAVEARSLSFNAQHIDIYSASWGPDDDGKTVDGPGELATRAFIEGITKGRSGKGSIFVWASGNGGREHDNCNCDGYTNSIWTLSISSATENGLVPWYSEACSSTLATAYSSGSLGEKQIVTIDLNHQCTSSHTGTSASAPIAAGICALALEANRDLTWRDMQHIVVRTAKPANLIAADWTINGVGRNVSHSFGYGLMDATAMVQLAKKWQTVPEQHKCEMLAPHKNRSIPSRSQLTLDFHVKECSGVNFLEHVQAKITLSASRRGDLEITLTSPQGTKSTLLAKRPHDNSKTGFQQWPFMSVHTWGERPHGTWTLEVHNEGRYVGRAILHEWSLIFYGTGILPDPTEFALYSSITGSGINPKFPKKPVVKTSNYSRNGLNVVGLKAKNSKFVKQQLQQQLQQQLQQGQNGGLNQAYIQQNQTAKKSKVRGQHKNGKSTNKPTVRPTVQSLRGLTFSRIAPPSKPRVSGSNVTAGHSSNPGNTTPKSIVEPVVKLTTQQPKQQQVIDAVTSTSSLQRGLILMEPAAKAATNKVPVVFQQYPKIQQLYPLYPVYPGVRGVNQHATRAKGLDLLQDEQFDTRNLQLTDKGTYSVDRDALTSLTEWGLVFYGTETALKFDEDLDKDKPIAPIEVEDIPHNRANSEDKKPVDTEGEGGSWRQQVDMISHPEVQKPTTENHTSKACKSFGSNGCLGGCLLLILLVHTLIKEPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HPG5</accession>
    <name>A0A8J2HPG5_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Gustatory receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HICCMSTLAB_LOCUS12984</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Cell membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the insect chemoreceptor superfamily. Gustatory receptor (GR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5107931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HPG5"/>
    <dbReference type="OrthoDB" id="6366728at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050909">
        <property type="term" value="P:sensory perception of taste"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013604">
        <property type="entry name" value="7TM_chemorcpt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08395">
        <property type="entry name" value="7tm_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 7" id="KW-0675">Receptor</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="49"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="94"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="148"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="181"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="267"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="308"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAG5107931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="362" mass="42110" checksum="5F20B089915EF1D6" modified="2022-05-25" version="1">MKNFNNNFLLFILVVKFFKVIGLAPYKLTILPNLQSKLKGQQFLGQTSYSLLGLMYNLVLTLTSIPTLYFWLPEVRKKTESSDTETQMEAWREFFFGVTSHGTFIITVLFCIVKQRVFIKVINRLFQFEKELTDTLYNTKNLLSGKSLLVIIFATHLSATVLNILTEFIAESKSITALDTILFIIPEFVIGNLVIQYALILIFLENRFKGLNKLLLSLVDTNCNESRCQKFFRIMSDSYEDNVVKLIRYIRDAQRNLYEISDDFSSCYSWPMLLSITYFAAGIIYSSYELFQNITQSETNILVSINLALWVIKTMIPIVTLTCCVTKIINEVTLKFLIFLLVKKRYRKKKFLIRPYMTIIHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HPK8</accession>
    <name>A0A8J2HPK8_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Similar to Mcfd2: Multiple coagulation factor deficiency protein 2 homolog (Rattus norvegicus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HICCMSTLAB_LOCUS10546</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5101644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HPK8"/>
    <dbReference type="OrthoDB" id="289247at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052110">
        <property type="entry name" value="MCFD2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23104:SF1">
        <property type="entry name" value="EF-HAND DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23104">
        <property type="entry name" value="MULTIPLE COAGULATION FACTOR DEFICIENCY PROTEIN 2 NEURAL STEM CELL DERIVED NEURONAL SURVIVAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035276849" evidence="4">
        <location>
            <begin position="20"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAG5101644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="173" mass="20059" checksum="1E4DA584AAF3F64C" modified="2022-05-25" version="1">MGFLEILIFFAAYLESSTGFRGPHHPKSSVSHHHYTPQGDIKLTQDSELLHDTAHLVEDMGTDYAGLSLDTMSEDEIEFYFFKMHDKDNNTKLDGLEILHALQHTYHTEEDYNEVDDYSQVDKIPMIIKMVDRVLEEDDLDNDGYIEYFEYVLAKEKKNSSEKSTTLESLNLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HPP9</accession>
    <name>A0A8J2HPP9_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Similar to Atrx: Transcriptional regulator ATRX (Mus musculus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">HICCMSTLAB_LOCUS11791</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF2/RAD54 helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5104001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HPP9"/>
    <dbReference type="OrthoDB" id="6286493at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005721">
        <property type="term" value="C:pericentric heterochromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031490">
        <property type="term" value="F:chromatin DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031297">
        <property type="term" value="P:replication fork processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11726">
        <property type="entry name" value="ADDz_ATRX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025766">
        <property type="entry name" value="ADD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041430">
        <property type="entry name" value="ADD_ATRX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052131">
        <property type="entry name" value="ATRX_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46357">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATOR ATRX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46357:SF1">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATOR ATRX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17981">
        <property type="entry name" value="ADD_ATRX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51533">
        <property type="entry name" value="ADD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="11" id="KW-0234">DNA repair</keyword>
    <keyword evidence="10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="15">
        <location>
            <begin position="56"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="199"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="747"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="792"/>
            <end position="913"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="201"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="244"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="796"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="852"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="895"/>
            <end position="913"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CAG5104001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="949" mass="107137" checksum="9737200B7F2F658A" modified="2022-05-25" version="1">MDISSLLEVQVNEGQASPELGSSDSVDQKPKNFIQYRPSEIVTPEESKFYRRMIGNDVAQVRFRRLHCTACDEHIGSAPIDAYNMQEHPMLKTLLCAHCREFYGDGDFEQGEDATDMFCRWCANGGNLYCCSYCCNTFCDKCIKRNFDAEVRERIEEDEKWRCFVCDPKDLYTLRGVCRALLLHVKTVTRILKSNPTMSQKDIENKMEQDDSKCCVGKRSTRRKRSVSSSSSLNDDIDQGSSAKKSKVKNGSNKNRKSTSKDHNYTNKPMQVISNGNTRFLSSTRFLPAEPSPPAHISDKDDIPAPLLHFEQTMIEGDGQVLPNQPNAKIPDSILNNSAISLNPIPKNLFHGPPGNIINLRPIRLDSVPPGATLHRLARIPTRPNAPMVTIPGRSVPITTANVNQTPKTFLRCKNLTALPTVALTTPNSTTPSVIDIDSDPEELPVTNNTTESSKAQQTSGQTVKVINPVALANAGLEDRSPIMSLDNPRRKVFDDVIYNPIKEVDKLITKIRGKLRMELKKAAGNLADNEAHNARVRLATINRCIYQAVDELSAFNNTMIQQYRPWKESLITGDPIDENTNKIVMKKGERSIKYTPFDMDCESESDSDNELDEVDDVDVEQLIDFTGKVRHFLEKDMINRSTNTEIQTKSQGVQVEEIIETKDYDRTIGYSLLMRTDYDFEKREEIYKPTKIHDHNFGKYEEQFIFYLQHLENRGEDEDTEDVVEKVPLTDLIDKDIARQEKTIEEDCDRSPRLDEVSDEKEKENDVDVDVVDLGEPVRGKTPVNIIAEEPGVEESEKNSDDTRVDTSSQDDIDVVNVSGEAMDVEENVDRPSEPSLETLNDCNGDKEISDGNEIDEENLNIEVTNHKSPEPLNNNSSIELDDVPGVSPAKSLNDSRENNEDKLTASQEAKHEETVIAVKTLIEENNSVDQFDRWRNNDEEDECMVLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HQ67</accession>
    <name>A0A8J2HQ67_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Mitochondrial (Mus musculus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS11044</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5102496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HQ67"/>
    <dbReference type="OrthoDB" id="10263536at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1250.10">
        <property type="entry name" value="Aminomethyltransferase fragment"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.120">
        <property type="entry name" value="Probable tRNA modification gtpase trme, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028896">
        <property type="entry name" value="GcvT/YgfZ/DmdA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006222">
        <property type="entry name" value="GCVT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027266">
        <property type="entry name" value="TrmE/GcvT-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43757">
        <property type="entry name" value="AMINOMETHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43757:SF2">
        <property type="entry name" value="AMINOMETHYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01571">
        <property type="entry name" value="GCV_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103025">
        <property type="entry name" value="Folate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GCVT N-terminal" evidence="1">
        <location>
            <begin position="2"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5102496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="94" mass="10572" checksum="816DF8F609F91921" modified="2022-05-25" version="1">MNSVETQAKKVNVRITRCGYTGEDGFEISFKGRHAEDIVEMILRQQEVKMAGLAARDSLRLEAGLCLYGHDINEETTPVEAGLTWLIGKSFYYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HQK2</accession>
    <name>A0A8J2HQK2_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NAD-dependent protein deacylase</fullName>
            <ecNumber evidence="5">2.3.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Regulatory protein SIR2 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HICCMSTLAB_LOCUS11350</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="5">NAD-dependent protein deacylase. Catalyzes the NAD-dependent hydrolysis of acyl groups from lysine residues.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>N(6)-acetyl-L-lysyl-[protein] + NAD(+) + H2O = 2''-O-acetyl-ADP-D-ribose + nicotinamide + L-lysyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:43636"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:10731"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17154"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="ChEBI" id="CHEBI:83767"/>
            <dbReference type="EC" id="2.3.1.286"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="5">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the sirtuin family. Class II subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="5"/>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5103119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HQK2"/>
    <dbReference type="OrthoDB" id="424302at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017136">
        <property type="term" value="F:histone deacetylase activity, NAD-dependent"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1600.10">
        <property type="entry name" value="SIR2/SIRT2 'Small Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01967">
        <property type="entry name" value="Sirtuin_ClassII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050134">
        <property type="entry name" value="NAD-dep_sirtuin_deacylases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003000">
        <property type="entry name" value="Sirtuin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026591">
        <property type="entry name" value="Sirtuin_cat_small_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026587">
        <property type="entry name" value="Sirtuin_class_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026590">
        <property type="entry name" value="Ssirtuin_cat_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003738">
        <property type="entry name" value="PRK05333.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085">
        <property type="entry name" value="NAD-DEPENDENT PROTEIN DEACYLASE SIRTUIN-5, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085:SF10">
        <property type="entry name" value="NAD-DEPENDENT PROTEIN DEACYLASE SIRTUIN-5, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02146">
        <property type="entry name" value="SIR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50305">
        <property type="entry name" value="SIRTUIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4 5" id="KW-0520">NAD</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 5 6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Deacetylase sirtuin-type" evidence="7">
        <location>
            <begin position="35"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5 6">
        <location>
            <position position="159"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="60"/>
            <end position="80"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="141"/>
            <end position="144"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 6">
        <location>
            <position position="167"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 6">
        <location>
            <position position="170"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 6">
        <location>
            <position position="218"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 6">
        <location>
            <position position="221"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="258"/>
            <end position="260"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="284"/>
            <end position="286"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="302"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG5103119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="317" mass="35805" checksum="007199A5CB6049DC" modified="2022-05-25" version="1">MNEVNILKNLNKTSGSWLFSSLKNFTNLSFVPKYEPPKPNDLIQLENFIRNKGKICVLTGAGVSTESGIPDYRSEGVGLYATSDRRPVLYQDFRKHDHIRKRYWARNYIAWPRFSEFQPNFSHKILKHLEDLNIVSCIITQNVDRLHSKAGSSHVIELHGTGYTVMCLNCDSKISRKDFQYILDKLNPTINANSKEIRPDGDIELSDKQAQAFVLPSCENCGGILKPDIVFFGDNVPRHTVEQVRHAVDEADALLVLGTSLTTFSGYRIILQAVEEKKSIAIVNIGETRADKYAAIKLNSGCGEVFKQLFPNLNFHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HQN4</accession>
    <name>A0A8J2HQN4_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">tRNA (cytosine(34)-C(5))-methyltransferase</fullName>
            <ecNumber evidence="3">2.1.1.203</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">HICCMSTLAB_LOCUS13410</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.203" evidence="3"/>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5108774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HQN4"/>
    <dbReference type="OrthoDB" id="6093671at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016428">
        <property type="term" value="F:tRNA (cytidine-5-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049560">
        <property type="entry name" value="MeTrfase_RsmB-F_NOP2_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001678">
        <property type="entry name" value="MeTrfase_RsmB-F_NOP2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057285">
        <property type="entry name" value="Pre-PUA_NSUN2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057286">
        <property type="entry name" value="PUA_NSUN2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023267">
        <property type="entry name" value="RCMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023270">
        <property type="entry name" value="RCMT_NCL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018314">
        <property type="entry name" value="RsmB/NOL1/NOP2-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22808">
        <property type="entry name" value="NCL1 YEAST -RELATED NOL1/NOP2/FMU SUN DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22808:SF1">
        <property type="entry name" value="RNA CYTOSINE-C(5)-METHYLTRANSFERASE NSUN2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01189">
        <property type="entry name" value="Methyltr_RsmB-F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25376">
        <property type="entry name" value="Pre-PUA_NSUN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25378">
        <property type="entry name" value="PUA_NSUN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02008">
        <property type="entry name" value="RCMTFAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02011">
        <property type="entry name" value="RCMTNCL1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01153">
        <property type="entry name" value="NOL1_NOP2_SUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51686">
        <property type="entry name" value="SAM_MT_RSMB_NOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="7 11" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="4" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="SAM-dependent MTase RsmB/NOP-type" evidence="13">
        <location>
            <begin position="62"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="439"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="705"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="12"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="448"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="470"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="721"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="11">
        <location>
            <position position="324"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="187"/>
            <end position="193"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="217"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="244"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="271"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CAG5108774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="747" mass="85530" checksum="2313EF6E24B108F3" modified="2022-05-25" version="1">MGRSRRNKPKKNFAEKRREKKENSGQFKKSLGRYNDIVRENKDFETYYKAQNVIPDDQWDAFITTIRENLPSAFRITGSQTEAKALLKIIKGDFFEEILNNKLEGEKEVANETEKMRPKSLPFYPNELAWQLQLTRKDIRRSEAYFKLHNFLIAETSSGNISRQEVVSMIPPLVLDVKPDHKVLDMCAAPGSKTAQLIEMIHADEGVVPKGFVIANDVDNNRCYMLVHQAKRLNSPNILITNQDSSIMPNYKITNPDGTQGILKFDRILADVPCSGDGTLRKNPDIWTKWSPANGNNLHGIQYRIVKRGLEMLAVGGKLVYSTCSLNPVENEAVLHRILAETGDSVQLVDGRDLVPGLKCNPGVSTWLLGSKDVKFYKSWEEVPETWHTQIRPKMFPPNPEDAPKFHLERCMRILPHHQDTGGFFVALLQKVKPLPWESESAMQGSNQDKEKNGEEIPKESMDVEDEKEDDKNDNNKRNLQDNKTAQPERKKKRIYGYREDPFVFFKDDKEDVWESIKKFYNISDELDPRCLYVRCHEGKKKNIYFTSPEIRDIILLNEHHIKMINTGVKTFVRCDNRNMKCAFRMAQEGLPSVIKFISDNRKVKIGQADLVMLLQNNNPKKPPEIELLSKETQERLKTVDAGSCILMYEEENSSDPLRLNLVGWKGTISLRAYVPISDTIHYLRLLGADCSKYEVNKFEQNRIANKANENDDSSVKADADEGEADNNDLATEEDSGAIDEQMEEVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HRG8</accession>
    <name>A0A8J2HRG8_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Similar to Rgn: Regucalcin (Rattus norvegicus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HICCMSTLAB_LOCUS11923</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="3">Binds 1 divalent metal cation per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the SMP-30/CGR1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5104280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HRG8"/>
    <dbReference type="OrthoDB" id="423498at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004341">
        <property type="term" value="F:gluconolactonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019853">
        <property type="term" value="P:L-ascorbic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013658">
        <property type="entry name" value="SGL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005511">
        <property type="entry name" value="SMP-30"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10907:SF66">
        <property type="entry name" value="MIP34848P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10907">
        <property type="entry name" value="REGUCALCIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08450">
        <property type="entry name" value="SGL"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01790">
        <property type="entry name" value="SMP30FAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63829">
        <property type="entry name" value="Calcium-dependent phosphotriesterase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035271054" evidence="4">
        <location>
            <begin position="17"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="domain" description="SMP-30/Gluconolactonase/LRE-like region" evidence="5">
        <location>
            <begin position="18"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="SMP-30/Gluconolactonase/LRE-like region" evidence="5">
        <location>
            <begin position="276"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="domain" description="SMP-30/Gluconolactonase/LRE-like region" evidence="5">
        <location>
            <begin position="518"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="2">
        <location>
            <position position="653"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="550"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="552"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="601"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="653"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR605511-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR605511-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAG5104280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="750" mass="82906" checksum="8D8707A443E28958" modified="2022-05-25" version="1">MKTFGVSFIIFFVTKCGPVSVVVPVAGRRNTFIAGCGQELVQVYWNPLTTNRNPRIEVLSRVDIGVPDTRFNDGKVDPRGRFWAGTMLIGSRQAHPPDQASVYRFAYNGTPTTMITPVSLSNGLVWSHSNNSFYYIDSLAYNIVVYDFNDTTVEMPVTEVSSVAFGGRNKDILYVTSARDQLNQSQLREQPLAGSVFAIYGLGVSGSPMLAILTQKLAMNIFTFFMNYQFLMAMSSVTQRTPEEIKFERIEGPYMCAEGPHWDYENNRLYYLECGSVGFAIPVANKKNTFITACGTNLIQVSWDPATDDLDPKVKFISQVDVGVSDTRFNDAKVDPAGRLWAGTMGEKDGLPVSGKGSLYRFDYDGTPKKMISPVDISNGLVWSLNKDAFYYIDSFAYVIDVYDYDDATGDISNRRTLFDLKANNITGIADGMTIDKTGNLWIANHSGGTVFQIDSKTGKLLRTIKMPMRDATSVAFGGPNKDVLYVTSSKDKMPEDLLKQQPLAGSVVAVYGLGCKTSIIILHWDPSTNNLNPEYRVISQVDQDISDTRFNDAKVDPRGRLWAGTMGEKNGVPLTGKGSMYKVDLDGTVAKMIDHVDISNGLIWNHFNDSFYFIDSFAYKIDEYSYDVNSGNISNKRTIFDLKKNNLMGIPDGMTIDKVGNLWVANHGGGLVLKIDPKTGRLLQSIKMPVTLVTSVAFGGPNKDILYVTSAKDKLNATQLENEPLAGSVFALHDLCISGSPMRSYVMNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HRH9</accession>
    <name>A0A8J2HRH9_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">tRNA (guanine(37)-N1)-methyltransferase</fullName>
            <ecNumber evidence="11">2.1.1.228</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">M1G-methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">tRNA [GM37] methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">tRNA methyltransferase 5 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">HICCMSTLAB_LOCUS13047</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Involved in mitochondrial tRNA methylation. Specifically methylates the N1 position of guanosine-37 in various tRNAs. Methylation is not dependent on the nature of the nucleoside 5' of the target nucleoside. This is the first step in the biosynthesis of wybutosine (yW), a modified base adjacent to the anticodon of tRNAs and required for accurate decoding.</text>
    </comment>
    <comment type="function">
        <text evidence="11">Specifically methylates the N1 position of guanosine-37 in various cytoplasmic and mitochondrial tRNAs. Methylation is not dependent on the nature of the nucleoside 5' of the target nucleoside. This is the first step in the biosynthesis of wybutosine (yW), a modified base adjacent to the anticodon of tRNAs and required for accurate decoding.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>guanosine(37) in tRNA + S-adenosyl-L-methionine = N(1)-methylguanosine(37) in tRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:36899"/>
            <dbReference type="Rhea" id="RHEA-COMP:10145"/>
            <dbReference type="Rhea" id="RHEA-COMP:10147"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:73542"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="EC" id="2.1.1.228"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="11">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Mitochondrion matrix</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="11">Predominantly in the mitochondria and in the nucleus.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the TRM5 / TYW2 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM5/TYW2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.228" evidence="11"/>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5108057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HRH9"/>
    <dbReference type="OrthoDB" id="408788at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052906">
        <property type="term" value="F:tRNA (guanine(37)-N1)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070901">
        <property type="term" value="P:mitochondrial tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002939">
        <property type="term" value="P:tRNA N1-guanine methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.110:FF:000001">
        <property type="entry name" value="tRNA (guanine(37)-N1)-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.110">
        <property type="entry name" value="Met-10+ protein-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03152">
        <property type="entry name" value="TRM5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030382">
        <property type="entry name" value="MeTrfase_TRM5/TYW2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031389">
        <property type="entry name" value="RBIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056743">
        <property type="entry name" value="TRM5-TYW2-like_MTfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056744">
        <property type="entry name" value="TRM5/TYW2-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025792">
        <property type="entry name" value="tRNA_Gua_MeTrfase_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23245:SF36">
        <property type="entry name" value="TRNA (GUANINE(37)-N1)-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23245">
        <property type="entry name" value="TRNA METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15679">
        <property type="entry name" value="DUF4665"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02475">
        <property type="entry name" value="TRM5-TYW2_MTfase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25133">
        <property type="entry name" value="TYW2_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51684">
        <property type="entry name" value="SAM_MT_TRM5_TYW2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 11" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7 11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 11" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="SAM-dependent methyltransferase TRM5/TYW2-type" evidence="13">
        <location>
            <begin position="157"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="505"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="246"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="284"/>
            <end position="285"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="311"/>
            <end position="312"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="341"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00045951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CAG5108057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="554" mass="64249" checksum="B7FC3D4F05EA5B11" modified="2022-05-25" version="1">MATRLIKYLSRILNFNNTLKIMNENTKMDNLLAPPDSVLGMKNLNRELFNKTIEIPCLILDVSTNYYNTVMGVVKKYFLKLKKFKSFTQDNENLTIYLDPRKVKKLDDIEESDRNKLNTISKLKFDKTQIKLNYHNWHADQLFRVILPNDIEIPTSYTKVGHILHLNLRDNQLPYKQIIGEIYLDTIPQTKTVVNKISNIETEFRNFNMEILAGDKNTETTVKENNCQFTFDFAKVYWNSRLSTEHTNLLKFMNKNDVLYDVFAGVGPFSIPAARKGVQVLANDLNPESFRWLQYNATANKAKKIISFNRDGRDFLRNEVKKHLLERRSRNQDGSEHIAMNLPAIAIEFCDVFRDWMDDNEIKLMSNKYPLIHLYCFVRVSKIDDPKPVAQALVEETLGTKLTPESLKIIHHVRNVAPNKEMMRVSFYLTKEMIKSEEPIVMGKNKKISKTKNVFKVNTKRTSKAKNQLNKNIGNKNQRKTLKKNIDKIQEIDKQLIDVRTRINSQSKPKEKTLAAPKKSVSKPQVQTSSAIDTLEQLNRCIYGLCVGASCIWC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HSB5</accession>
    <name>A0A8J2HSB5_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Similar to zag-1: Zinc finger E-box-binding homeobox protein zag-1 (Caenorhabditis elegans)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">HICCMSTLAB_LOCUS12378</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5106675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HSB5"/>
    <dbReference type="OrthoDB" id="7491548at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000013">
        <property type="entry name" value="Putative zinc finger E-box-binding homeobox 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000744">
        <property type="entry name" value="zinc finger E-box-binding homeobox 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000016">
        <property type="entry name" value="zinc finger protein 37 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000145">
        <property type="entry name" value="Zinc finger protein 574"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051574">
        <property type="entry name" value="ZnF_E-box_Homeobox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24391">
        <property type="entry name" value="HISTONE H4 TRANSCRIPTION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24391:SF27">
        <property type="entry name" value="ZINC FINGER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13894">
        <property type="entry name" value="zf-C2H2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 10 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7 10 11" id="KW-0371">Homeobox</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 10 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="87"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="118"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="146"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="domain" description="Homeobox" evidence="13">
        <location>
            <begin position="437"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="602"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="630"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="658"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="10">
        <location>
            <begin position="439"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="281"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="350"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="576"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="281"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="354"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="365"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="419"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="578"/>
            <end position="587"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CAG5106675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="689" mass="78037" checksum="283885AB3F1258A0" modified="2022-05-25" version="1">MSMTLVRNAFKGCSGDESSVELAEVSNGGASTEGGGGESRSAKQEERCPQCGILCRNLHVLQLHLEDAHKTAFVIDKHDLSVQFSQVSCKVCSKTFANVYRLQRHMISHDESAVLRKFKCPHCEKAFKFKHHLKEHLRIHSGEKPFQCNNCGKRFSHSGSYSSHMTSKKCLIVNLKKSRQSTISSIERATKKPQIQQGGGQSLQSRGAREIDIHAANNNTFLPILPKLSPSDYHELQRETTGIYDMPTLLPPIVNFSSLFLQSSLGKILNQLQTKRLDEVASEHYEAHRETLSPSTADSEETEGKYSPVPTDPQGLDAVRRILETVNTSVTKQLLEANVRKLATSPETIKRECDEDYHDQDSEMSGETTHYQDWQTGDQYDSQSEGLAAKLEDASQSSTKARRGSKRKAEEGFAPESSIEADSDDEDESNKTQAEPGRRVRARSLIDDEQLAVLKGYYAINPRPKKEEIDMIANYINFPKRVVQVWFQNSRARDRRELRMPALVPLANIGNHQLPCSLEQPLDLSKKESLTITPSVKDNDIISNRNNVSSPHEPKDYNKIIQMTVPHSEVDDLDELPLSERENDRPVPDAPPSTETEQEGVYVCDQCDKTFSKHSSLARHKYEHSGQRPYKCEECPRAFKHKHHLTEHKRLHTGEKPFQCTKCLKRFSHSGSYSQHMNHRSSYCKPYRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HTQ2</accession>
    <name>A0A8J2HTQ2_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Mitochondrial (Homo sapiens)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HICCMSTLAB_LOCUS13316</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5108596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HTQ2"/>
    <dbReference type="OrthoDB" id="439710at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004815">
        <property type="term" value="F:aspartate-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006422">
        <property type="term" value="P:aspartyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00777">
        <property type="entry name" value="AspRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04317">
        <property type="entry name" value="EcAspRS_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.30">
        <property type="entry name" value="GAD-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00044">
        <property type="entry name" value="Asp_tRNA_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004524">
        <property type="entry name" value="Asp-tRNA-ligase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047089">
        <property type="entry name" value="Asp-tRNA-ligase_1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002312">
        <property type="entry name" value="Asp/Asn-tRNA-synth_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047090">
        <property type="entry name" value="AspRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004115">
        <property type="entry name" value="GAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00459">
        <property type="entry name" value="aspS_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001750">
        <property type="entry name" value="PRK00476.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22594:SF5">
        <property type="entry name" value="ASPARTATE--TRNA LIGASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22594">
        <property type="entry name" value="ASPARTYL/LYSYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01042">
        <property type="entry name" value="TRNASYNTHASP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="7">
        <location>
            <begin position="115"/>
            <end position="515"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG5108596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="552" mass="63063" checksum="B041E1A0AA7DDB1B" modified="2022-05-25" version="1">MEYQRMGKFITLRDSYGTIQLMIPDDKQSLIKAVEQSSFESVLSVTGKVILRPPEQENRKMKTGSIEILVEALEIVNNAASQLPFYIREHNVPKEMLQMQYRYLALRFPSMQNNLRLRSEFMHKLRGYLIDDCGFVDVETPTLFRRTPGGAQEFVVPTRQPGEFYSLVQSPQQFKQLLMVGGIDRYFQMARCYRDEGARSDRQPEFTQLDIEMSFTDREGIISLIEDLLCHCWPKESAALTTPFRHFTYEQVMELFGTDQPDLRLPYRILNLQQSDSRGDNEIYALPIPMGAEFLTNAVKAQLNDIRDKNFKGVKLMQIKIQDDSWPEKVEKFGVDISGMNQKLSVNKTDALFLASGNKNNVRKLLGKILVEFANIIESKGRQIRTQGYEFLWIVDFPLFEKNDDGSIASTHHPFTAPHPDDFQYLETDPFKVRGLHYDLVLNGSEIAGGSIRIHNAKLQEKILKMLNISTSQMKHLLEALASGAPPHGGIAFGMDRLISIICKSPSIRNVIAFPKTMEGRDLMSGAPTEISEEEKKLYHLSILSNENEKNC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HUG0</accession>
    <name>A0A8J2HUG0_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS13924</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5109288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HUG0"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5109288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="196" mass="22870" checksum="09E2C7CE52DED1E0" modified="2022-05-25" version="1">MLQEIRKSLNTLEKIEFVDVDSDMLSSSDTLSSSSSILPFQTFINKCHLLISSDDTTAYRILGESRQFLILLQTDIEDHLNCQLRLSLLHKHQRVPKKHLDHTLIPILLIEFTRTICVSQLHEIIFQLIIRIIIVKVVIHSSLYIGIKVQSRSQNWDSFIQKTNFFFFTEEANIDEARPVRLFPFNRQLFSILQVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MBT2</accession>
    <name>A0A8J2MBT2_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS2849</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001117">
        <property type="protein sequence ID" value="CAG5078818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MBT2"/>
    <dbReference type="OrthoDB" id="7699805at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5078818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="135" mass="15792" checksum="51A8DBB0A681EE54" modified="2022-05-25" version="1" fragment="single">ALIFGEFFLHGKHPQNHRNISSHSLLIQLYIVYPMVQHISSKLWSRFLSEDKIDKFSKSASPFIGGHDYLLNCDYKLTSPNNNERIVKFRDFKRCDHLALFQALSQRLDLRNMDIDDKDPNELTSIFLTLQSSIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MBW6</accession>
    <name>A0A8J2MBW6_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS3577</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5082491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MBW6"/>
    <dbReference type="OrthoDB" id="159395at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5082491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="102" mass="11564" checksum="6F8A40ACA51C9C2C" modified="2022-05-25" version="1">MSPRKSESSLLINARWASSSLAFWVRNTSANSLFSSVTALPNHLILSRSFFASLPLPPRNPDHQLSVFFNGLLERTIKRIVVLLPMIQKCIYLFTEQFNRAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MG95</accession>
    <name>A0A8J2MG95_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Structural maintenance of chromosomes protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">HICCMSTLAB_LOCUS5033</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SMC family. SMC2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5088939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MG95"/>
    <dbReference type="OrthoDB" id="10255539at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030261">
        <property type="term" value="P:chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03273">
        <property type="entry name" value="ABC_SMC2_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1060.20:FF:000005">
        <property type="entry name" value="Structural maintenance of chromosomes 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000385">
        <property type="entry name" value="Structural maintenance of chromosomes 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1060.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003395">
        <property type="entry name" value="RecF/RecN/SMC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024704">
        <property type="entry name" value="SMC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027120">
        <property type="entry name" value="Smc2_ABC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010935">
        <property type="entry name" value="SMC_hinge"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036277">
        <property type="entry name" value="SMC_hinge_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43977">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06470">
        <property type="entry name" value="SMC_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02463">
        <property type="entry name" value="SMC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005719">
        <property type="entry name" value="SMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00968">
        <property type="entry name" value="SMC_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75553">
        <property type="entry name" value="Smc hinge domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="7 12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0226">DNA condensation</keyword>
    <keyword evidence="5" id="KW-0498">Mitosis</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SMC hinge" evidence="14">
        <location>
            <begin position="504"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1153"/>
            <end position="1172"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="237"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="418"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="722"/>
            <end position="900"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR005719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CAG5088939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="1172" mass="134141" checksum="C41792DB7B86675C" modified="2022-05-25" version="1">MYIKSLILDGFKSYGKRIEINGFDKEFNAITGLNGSGKSNVRATSLQELVYKSGQAGIKKAVVTITFDNSDKKASPIGYENYDEIAVTRQIVIDGKNKYLLNGTNVTNQRVQDMFCSVQLNVNNPHFLIMQGRITKVLNMKPLEILSMIEEAAGTRMYEEKKESAMKLIDKKKAKLKEINDILEEEINPRLVKLREERAQYLEYQRVEREFEICKKIVTAWKYYSAVKTSDKTNADLNKIQADIDAKQEAIEEGKEQIVKIESDVKELIDKMEKEKSNKLETMEQELKVTEKKEIKLSAKINSDKERIKTVVHELDQLKKSLEDDIQGAEQRKKDLEEFGGKFDKLRQAQEEDAAAVLAAQDKYQKISTGLLENEDGENATLCQQLMDAKQAASMAETVIKQTEMITKHDCEQLAIKQRDLKNTNSDHTRIVKELKEKEQYLKSLETKLNQINYTEGNLEKLQHQRQQLNQEIRGINDQIDNFLDRYPNLRFDYSNPEPNFNRKAVKGLVCTLFGLKERNAAYALEVAAGNKLYNVVVDKETTSKALLQRGNLQRRVTIIPLNKISGQKINEATVRSAEQLVGKDNVKTALSLIEYPNELSAAMSFIFGNVFICKDLTVAKKVAFDRNIMTKCVTLEGDVCDPSGTLSGGAPASAGSILTKVSDYKVLLNQLETKQANLEALDLEITNETPKAKRWSKIKEQFVLQEHEVEAARQMLAVDEHFQLEEEIKSLTEKIKAAEEKIKVNRELKKKNDARVKVLEKQLEDIDSVQEQQLKEVKKQLELLQKKASASKKEWEKHESDAQMLVMQVEEDKKTIAHDEEQIKRTEERLGELQQQHDVDLEELRKLVEEIKEKQEEVKRHKVLVNQQNQEVQRLVARKEEIKNLSKEYELDIKKLTHEIGTIKSNAVDCQQKIKDLVKNNPWIEQDKKYFGVPGNMYDFEAKNPTNLIDELNHLKENKEQMSRSVNTRAMNLLSMEEDRYNETIKKRTTVENDKKNILFTVQELEEQKKNTLMTAWEQINKDFGSIFSSLLPGAKAKLQTLPNKNVLSGLEVKVGFGNVWKESLGELSGGQRSLVALSLILAMLRYKPAPLYILDEVDAALDLSHTQNVGTMLKKHFNNSQFIIVSLKDGMFNNANVLFTTKFIDGMSSISREEKGRRQNNADRENNPSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MHW0</accession>
    <name>A0A8J2MHW0_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Similar to slc7a6: Y L amino acid transporter 2 (Danio rerio)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HICCMSTLAB_LOCUS6467</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid-polyamine-organocation (APC) superfamily. L-type amino acid transporter (LAT) (TC 2.A.3.8) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5092948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MHW0"/>
    <dbReference type="OrthoDB" id="3257095at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000003">
        <property type="entry name" value="Y+L amino acid transporter 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050598">
        <property type="entry name" value="AminoAcid_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785:SF535">
        <property type="entry name" value="GH08870P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="35"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="73"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="103"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="143"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="180"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="227"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="278"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="304"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="334"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="360"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAG5092948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="411" mass="45736" checksum="EFB91F534F97CA86" modified="2022-05-25" version="1">MIGALCYAELGTSIPRSGGDYAYIHEAFGELPSFLYLWAANLIFVPTTNAIMALTFAEYVLQPFFQDCVIPDASVRLIAACTICLLTFINCYDVKETSKMQNIIMFAKISALFIIIIAGLSWLCLGHTENYEEPFKSTTVDPGKIAIAFYSGIFSYSGWNYLNFMTEELKDPYKNLPRAIYISLPLVTIIYALANVAYLAVLNPTAMIASHAIAVTLADKLMGPMSWIMPVLVATSAFGGLSVHIMTSSRMCFVGARNGHFPAMLSHINIKRFSPTPALVFLCILSLMMLCTSDIFVLITYCSIVESFFIMISVAGILWLRYKRPNMPRPIKIPILVPIVFVIICLFLVIVPCLERPIEVGMGALITLSGVPAYFAGIVWKNKPMWFLNLNEKATHVVQKLFISAREEKDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MJ96</accession>
    <name>A0A8J2MJ96_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ctypelectin_Cc</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HICCMSTLAB_LOCUS7561</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5095142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MJ96"/>
    <dbReference type="OrthoDB" id="8950604at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00037">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018378">
        <property type="entry name" value="C-type_lectin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21407:SF1">
        <property type="entry name" value="RE43931P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21407">
        <property type="entry name" value="RE43931P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00615">
        <property type="entry name" value="C_TYPE_LECTIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035234434" evidence="3">
        <location>
            <begin position="18"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="4">
        <location>
            <begin position="46"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="139"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="139"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAG5095142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="217" mass="24705" checksum="A9120B28866BD153" modified="2022-05-25" version="1">MKSALFLLFFGIVAVTAQRRLALPDPRSCANRVRHASYRDARGVAHSYFFSWEHQPTRSLEVDWLDSRNICRRHCMDAVSLETPQENEFIKQRIARGNIRYIWTSGRKCNFNGCDRPDLQPQNVNGWFWSGSGAKIGPTTQRNTGDWSNTGGYGQAQPDNREAAQGNDESCLAILNNFYNDGVKWHDVACHHLKPFVCEDSDELLNFVASRNPGIRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MK07</accession>
    <name>A0A8J2MK07_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS3154</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5080962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MK07"/>
    <dbReference type="OrthoDB" id="7679028at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035176623" evidence="1">
        <location>
            <begin position="25"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5080962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="304" mass="35585" checksum="A6E2CE4679B2F349" modified="2022-05-25" version="1">MRRMWKKIIIWWLIAVYFFDKNSAFDNILYKRSPTPYTQMGQLFKSCYSDRLNPVVITTNLIDIIEELPVEDVSFSMMTIDCNFKAKDIQIFIPAYPLYIVSTDSTDQLQGLLNELKSTPTWNIVSIFLFIEAEGNYCQNASQVLQLLWKFDLLSSFYFCIEPNNDIMLYTYNPYTNRAPDLWTEVNTDDKPNNWWTLYKQLYIPKDEGVCQSLSYDKTTALDGYEVKAASDSMSWEHITRNETYNISSFDETLMNGDRTFMVTLFTALNVTPKINYDDPGAYKNNTVKATGKRNPRYKYFCPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MKF4</accession>
    <name>A0A8J2MKF4_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS8346</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5096710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MKF4"/>
    <dbReference type="OrthoDB" id="10505227at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="65"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="131"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="104"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5096710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="299" mass="34249" checksum="DC589E75F4CEA65D" modified="2022-05-25" version="1">MSDQIDKFCLVQNGKDGWIVETKFVFKLGTDGNPVPIDLNEEEDQICFVKTDTRQINNVVVVGSSVEHDEDSESNVNPRRRTVPSPPIRNDTFERVRARSARLSGTGSSSGNNGRRSRRVNSVIRRPLRSRQSLIAKIKSLERSVNSLRKTVRKLLKKVGQGNDNVTQERYPELEQRVIVEGGNEFVEIEGVKIDGEQYAKMLLQNSLRGRANVLMHDMWPDNVMRRMYLKAPPGTQNYEIVKSTDIQKIKNICLYLQRKKKIEYISGGKDDVSIYARNWAGDLFKNCRKKLNDQNVPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MKQ2</accession>
    <name>A0A8J2MKQ2_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to Igbp1b: Immunoglobulin-binding protein 1b (Mus musculus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS5925</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IGBP1/TAP42 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5092118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MKQ2"/>
    <dbReference type="OrthoDB" id="10261753at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051721">
        <property type="term" value="F:protein phosphatase 2A binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035303">
        <property type="term" value="P:regulation of dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009966">
        <property type="term" value="P:regulation of signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.540:FF:000003">
        <property type="entry name" value="Immunoglobulin (CD79A)-binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.540">
        <property type="entry name" value="TAP42-like family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038511">
        <property type="entry name" value="TAP42/TAP46-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007304">
        <property type="entry name" value="TAP46-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10933">
        <property type="entry name" value="IMMUNOGLOBULIN-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10933:SF9">
        <property type="entry name" value="IMMUNOGLOBULIN-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04177">
        <property type="entry name" value="TAP42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="286"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="310"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="337"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00034730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5092118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="349" mass="40528" checksum="DE66EE83978B0CA4" modified="2022-05-25" version="1">MASAESEENLSDLFDSGYKLFTSIQNTQSATNSLEVQLDVKKCISIFETATKLVSIADMFSRNEEFTEVPTENIKYFLLPAFLGTLASKICDRENRMHYLKVSEVYFYDFLERIKSYGVINFEIPKKDQEDDDNDKKEGDKKKTSNLEKIEDMVSIRKLKLMRYKEQKDLKEKLEVYQKSMDNPNLDDETKRNYFTTLINLYALEAVDEINSLKEEKAILEQMKMISSGKLEDKKKDNYKPPKLQPIIITKNQLQKQVMGAGYPSLPVMTVEEFYEKKIADGEWAAPGTNVGGKSLQDMAESQGQEDPEVLEKEKLAEKDDEEYLNRMRAMDEYKDTHKRGWGNRYNRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2ML09</accession>
    <name>A0A8J2ML09_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF243 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS5883</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5092053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2ML09"/>
    <dbReference type="OrthoDB" id="6376010at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062129">
        <property type="term" value="C:chitin-based extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008010">
        <property type="term" value="F:structural constituent of chitin-based larval cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040003">
        <property type="term" value="P:chitin-based cuticle development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004145">
        <property type="entry name" value="DUF243"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31927">
        <property type="entry name" value="FI07246P-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31927:SF13">
        <property type="entry name" value="TWEEDLEBETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03103">
        <property type="entry name" value="DUF243"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00690">
        <property type="entry name" value="DM5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF243" evidence="2">
        <location>
            <begin position="51"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="127"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5092053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="181" mass="19533" checksum="CF7749649FBA147E" modified="2022-05-25" version="1">MIFGCAWAKPAPEPPVDSYFPPSSGLIGGGGGYPSGPANVQDTYGPPQRQPVIHKHVYVHVPPPEAPEYKPPKYLPPQQAPQKHYKIVFIKAPTPPTPTAPVLPALPPQDEQKTLIYVLVKKPEEAPDVVLPTQAPTQPSKPEVYFIRYKTQKEQSGSYGPPAQQPPDSYGPPSAGNGGPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2ML54</accession>
    <name>A0A8J2ML54_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNase H type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS6761</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5093349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2ML54"/>
    <dbReference type="OrthoDB" id="7610697at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09276">
        <property type="entry name" value="Rnase_HI_RT_non_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002156">
        <property type="entry name" value="RNaseH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00075">
        <property type="entry name" value="RNase_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50879">
        <property type="entry name" value="RNASE_H_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase H type-1" evidence="1">
        <location>
            <begin position="55"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5093349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="303" mass="34798" checksum="A61F1ED4842C12FB" modified="2022-05-25" version="1">MFTNIAVHKRMIHPIPPWEFFEPLIDLHVYNNSFGKDLTTKQTYSNLTTEMYDKYNGYCKLYTDGSVKNGKKGCGIIHDDQTFMYHLPDFTNIFSCEVIAIKKAIDHIIENNIQKAIILTDSKSALDVISNTTNKDPRIIKIQSKLHQLNDRQYHTILAWLPFHQGLQGNEEVDLAAKKALTEGTLTTNEQATPDEFKKVVNAYIWAKWNGNWMSSDSLLHQVRANVWEIPPKSSNRKIQTIITRLRIGHTYITHNYLMSRETHTKCPKCNAPITVHHILAECPLNTAPIHQVQRPNGKIPRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MMG2</accession>
    <name>A0A8J2MMG2_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Similar to Nfrkb: Nuclear factor related to kappa-B-binding protein (Mus musculus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HICCMSTLAB_LOCUS8014</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5096047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="70874at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031011">
        <property type="term" value="C:Ino80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002020">
        <property type="term" value="F:protease binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21865">
        <property type="entry name" value="DEUBAD_NFRKB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2430">
        <property type="entry name" value="NFRKB winged helix-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044867">
        <property type="entry name" value="DEUBAD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024867">
        <property type="entry name" value="NFRKB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025220">
        <property type="entry name" value="NFRKB_WH_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057748">
        <property type="entry name" value="NFRKB_WH_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038106">
        <property type="entry name" value="NFRKB_winged_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13052">
        <property type="entry name" value="NFRKB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13052:SF3">
        <property type="entry name" value="NUCLEAR FACTOR RELATED TO KAPPA-B-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14465">
        <property type="entry name" value="WHD_1st_NFRKB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25793">
        <property type="entry name" value="WHD_2nd_NFRKB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51916">
        <property type="entry name" value="DEUBAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEUBAD" evidence="4">
        <location>
            <begin position="49"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="1174"/>
            <end position="1203"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="1396"/>
            <end position="1432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAG5096047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="1448" mass="162033" checksum="C6DB95460F9E52C3" modified="2022-05-25" version="1">MSAQLVATQMLKKRRMKNLITDLGVTHVPVVQAARWETCVAAGSKIKLPQDLCEHSSIFYELLEYPNIWQDCLNQEQRESLSRYMPNFPTDCDVAAEQEKTLKMLFQREIHRFGVSPLESFHTHLSSGHFRPDIRRMRRLVRKAQKRRLLFEERKRTYELANQLFKSRENLLLNAYKQGFSQPTAHRMSKLHWRKPTPAILEEKTQMRYVEELNAVKAELGIARFADTTSENEENYHQFQIPNTKQKKKRKSPGIQATQMRTNHLNTDDEEIRPVFSTLQREEFTPNPSFLVREMNEDLYRTMLIAHKRRRARQDIHPELNTQGIVLAELTQRAQVGQKHKLTFSNPVRINSPKKRVKVEPSLCPPVIPNKLIPTSSAVKTELDSNNYSYNNAIEDNNHVFNKEIEPKVCQETLRSTNIIPVKIEPTDSFDISPTSAKKKINVITPKYNKPVVVAPAPVPIPEPLPQLPEIKKELEELDYMRTEVKSEYIIPDEISAVSEEEEEEEDLDSKKELDLENIDMMQIPIQLDDGIDILDDVQVQCEDNRVIGMPDKNISITAEEDDIRINGSGDLMQETHTCFFSLLRDAFVSKGEFRMNTAEVKDAVSLWQNNPISPLNDWYSLSNSWSALVSSALGFLAGELVCIQETDQQDSEFVPYLENKGRGIYAWIGAGRDSDSRLAVLCNQFLMYRNVLSTPKLPSFTESTPVIVPIKTTAAPVMYGNGSSNGSGTNNVRSGSPAVESIGDAAAAMTESEPPRALCPTDWKVRLSTPEEREEFQRQERLRYASPHKAFTYKMHGYESVVGPVKGIYHHNIGAGLTKPRGHSLLVADRPNFVTILALVRDATARLPNGEGTRADICMLLKDSQYIKEYSPNDGEKCNEKDNYLNSVVSGALDRLHYETDPCVRYYPRRKEWLYLHRARSESEFEMYHQQLQGVTKTKKNPGGNSRNKTVQLNHKLMNGKEQVPNALKESTPKKEKKIALQTQLIIKKEPRVPEDKIRIDQSVSIETPVTSTMSTVISTVAPVTSSVPPVIFSTPAVVSSSTIERDSAAAAAAAAAAVVEMKPQISPAIPTVKKMGSISGKPVTVVKTAGTQSLLQSNQHFPHHQIQVSTSAGVQTIRLSGPSVLQSAQAVSAITSNAGTSTPNVTAIFPTAKIHNQVQPTVLTNQTGKSILQNTNIKQQQQQQQQQQQQQQQQQQQQQQQPPQQQQQQHVLPGKTLLASQIKLVSSGQIKSLLTGHGLQGPTIFIKQSSPSATHAQQIQQLKLVSQAQGSPGQTKIVVSSQQSQTPGAQTVRMVAAQLAGKPIVLASANKGVVTGITGGNSVVLGKQSPQQQQAGQQQPIILPSHMLKALQGLKVIPTPAGLKTTGTAVYARVLASTSISGTQTTPQQQHLQQQQFQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQIIQTSQTTRNNPYSAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MMP4</accession>
    <name>A0A8J2MMP4_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HICCMSTLAB_LOCUS7624</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5095268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MMP4"/>
    <dbReference type="OrthoDB" id="249932at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042078">
        <property type="term" value="P:germ-line stem cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20435">
        <property type="entry name" value="Tudor_TDRD12_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22655">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE TDRD12-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22655:SF2">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE TDRD12-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 13" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="12">
        <location>
            <begin position="341"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="11">
        <location>
            <begin position="724"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="8">
        <location>
            <begin position="724"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="264"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="50"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAG5095268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="1001" mass="114047" checksum="5B78E0ACA57351B7" modified="2022-05-25" version="1" fragment="single">TQKITTKSFVTYFYQNYIHTFFLSHILVVINHKIPPHAVEVTVEKLTHPSKILIRDVNNVEEKLKAINEKLIVIAQKYRKTEENVNYNSIPLGSLVITNRDTPDGIDLPAWYSRALIIGYDHDTLKYAAFLVDYGVKFDLCRQALIVIPKDAIPNHYLTEMVSLYRIIPAIIKSNNEDFVELLAKKTWCPETIDLAKQLICASKKCYFEALASGNSGKKYGELYLIIENQIIMLRKALVKAHRAILVNNDLLEVKSSDSFTSVKSFSSPIVDSDNKSDSNNTSASINSVAQRVGFEEILVSGNEQCTRLHDIASAKFTRHVHQALNKISVRKVRNLQSYMWPAISKGLDVMAVGPARSGKTFGFIAPIANMIIKTRQYQEDGQPMALILCPSAKEVLYTKEHFRLLLSEYSDIKIIGAFNGCEYRSITAQIYNGCHIFIATPAFLFRYLEDKDNCAPVKFNSINHLVIDHLDDLLTKHLDSLMLLLKKYTPFEKQKSQTSRLMALQIIAVARQWSRVLGTFTQKFFNNPFYCIGSFADATIFCGIQLRTRSILKENKLVKTEELLDKHYKLVKTMIVCAEGEEARELNDYLVSKGIRTLYVSEEMVRAEIGDIKQCWDREISGNYGVLICTDKPLPTLEITNVDWLIHYSIAVPTKSIFLFRFSTLMTNLQKKSTSTEVTIFIDESNDIQLRGILNLVERSGYKLSAEQKNAFERVYVNLERQKKAHPICDGIKAFGSCEKGNACMYRHCFVAEADTPITPVKIGDKIKINITYLHDATHFSAKIQEYIDSEGTKHLISPAAHIEIESKVYQYFAATRNRRKCRTVEIGGIYGYDERLDEYCRAQVINVVKKVDDVPQIVDLRNIDSGLVYTNQNVSRLRELPQELAEAPAHIVEVFLANVSPFDKEVEWNVRANQASKSWFTEHLEAPCTSLRGTVVLHFGNTVWVDPLEVRMQISIANKELQKSSLKDFLIKKKFGVANYNHIQILKKMCNYADMLELE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MNM7</accession>
    <name>A0A8J2MNM7_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Similar to RBM25: RNA-binding protein 25 (Homo sapiens)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HICCMSTLAB_LOCUS9924</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5100851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MNM7"/>
    <dbReference type="OrthoDB" id="6275295at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000381">
        <property type="term" value="P:regulation of alternative mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12446">
        <property type="entry name" value="RRM_RBM25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1390.10:FF:000004">
        <property type="entry name" value="RNA-binding motif protein 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1390.10">
        <property type="entry name" value="PWI domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002483">
        <property type="entry name" value="PWI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036483">
        <property type="entry name" value="PWI_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052768">
        <property type="entry name" value="RBM25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034268">
        <property type="entry name" value="RBM25_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18806">
        <property type="entry name" value="RBM25 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18806:SF4">
        <property type="entry name" value="RNA-BINDING PROTEIN 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01480">
        <property type="entry name" value="PWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00311">
        <property type="entry name" value="PWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101233">
        <property type="entry name" value="PWI domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51025">
        <property type="entry name" value="PWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="84"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="PWI" evidence="6">
        <location>
            <begin position="808"/>
            <end position="901"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="45"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="169"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="264"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="536"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="58"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="71"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="175"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="186"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="264"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="320"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="335"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="549"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="591"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="615"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="646"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="709"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="766"/>
            <end position="793"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAG5100851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="901" mass="104994" checksum="5C8060171F9D22BC" modified="2022-05-25" version="1">MSYPGQPPMGIPGMPPMPYMVGAPPPMLGSVMPMPHMIPTPVSAMQTSAPAVRYTRTQQQQQQPQQAPRPEAPKRRERENGPAVTVFVGNIMERAPDIMIRQILGACGHVVSWKRVQAFGFCEYAGPDAGLRAVRLLHDMEIGTKRLVVKVDAKTKVVLDQFKAERRKKLKGGQSPLQDETPSENADGDDSDDYMDEGMRVVDQDALTRIAQVIKEHATEIETAQAAADARKSEDLLKSKGLNLDDAEIEESKRDLITREIGKFREVMKKQEEEKAQVKRKREAVEKEEREKRERERKDRRGDDDGREERDGDFGSPVSHKAHNDRRDKRRSKSRSKERERDRDRMRNDRNREHNRDRERDRDRERERDRDNRGDRNDRDRERDRERERDRDKDRDRDRERDREREREEVRKSEREIMREHEEEEEAKERKKIERRAREKEAAYQDRLRQWEGRERRKQKEYEKELDKKRAKREAREKEATRLKEFLEDYDDDRDDSKYYKGKELSRRLEERALEAEADSRDRCAERQELQRLRDKLYADASHPDPAAEFERLKAEREEQYKPKPIITIIDEDDEKIEKGKDGVMPPIETEPIDSDSDDDVQFEEAPLPEPSRTPPRHHHHHRRHHRHHQNHHRDSDNIDGMGSEQSRDGTKDRRISSPGIQVIGTPTQPPPTHDEDSRMSLVSEPEKTSGSNFVPFAMGGSGNRNSDHNSGNKTPASPNSANNLQSAQQAKKKTRMDVKDVFNNDDDDDGTNNSKKRKLVPLDYGEEKKKKGGDDSSKGGKEESTKSQEEKRKHIKSLIDKIPTDKNALFGYQLDWAVIDNTLMEKRIRPWINKKIIEYIGEPEPTLVDFICSKVMAGSSPQGILDDVQMVLDEEAEVFVVKMWRLLIYEVEAKKMGLVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MNY0</accession>
    <name>A0A8J2MNY0_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS8879</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5097791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MNY0"/>
    <dbReference type="OrthoDB" id="10004641at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="69"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5097791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="95" mass="11097" checksum="0058FB623AFBE465" modified="2022-05-25" version="1">MIVNIGIFVSLFREIWLKEGTNEVSLVAEMLEQYEQYEQWFPERVKPKMGARTSGTYVSASVDKPAQLHICSACGKRYKWLDSLRRHQRVEMAET</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MNZ9</accession>
    <name>A0A8J2MNZ9_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS8954</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5097941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MNZ9"/>
    <dbReference type="OrthoDB" id="6162903at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34494">
        <property type="entry name" value="PROTEIN CBG25024"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34494:SF1">
        <property type="entry name" value="PROTEIN CBG25024"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5097941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="160" mass="15984" checksum="FF8B6B32F39230F4" modified="2022-05-25" version="1">MDFLSWATNSIPVVGHVKGIVHYAVGDTKGGHQAMFQATRTAAVVGAGTAGALAGPAGTLYFGSVAQVMSDSVGTMILDEPQGVNWACSEIQNGNEAMSQATRIVAVVGAGAAASLAGLAGIVASTATNAQVISDSIGAVVLNEPQGVNMACRTVVEQKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MPF8</accession>
    <name>A0A8J2MPF8_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HAT C-terminal dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS9621</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5100548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MPF8"/>
    <dbReference type="OrthoDB" id="10023262at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008906">
        <property type="entry name" value="HATC_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37162:SF1">
        <property type="entry name" value="BED-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37162">
        <property type="entry name" value="HAT FAMILY DIMERISATION DOMAINCONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05699">
        <property type="entry name" value="Dimer_Tnp_hAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HAT C-terminal dimerisation" evidence="1">
        <location>
            <begin position="258"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5100548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="399" mass="45314" checksum="B507CC4616207E85" modified="2022-05-25" version="1">MNAGKKPSKLVQLAPTRWLALAGAVTSNLKQWEELKHYFNSIKDSSSEKSYTAKSLAEMYNDDRNRLYLIFLNQILREITTMNLAFQAADADLTKLYSDLRCLLLSLARRIFQPSFLRPLVSDTSDATMLHEADIKAVQNVLLKSKQAIGNSLLPINCVDFGSSFAAFAEKKTISDVHLHEVKVRSLNFIIVLCEQLVQRLPTNLVVIDKLRYFAPKNCLSLSSANIMDNLPWDLAVAIQWRLLNTLRFHDINEKFDDNVKPIDFWIAVLDMRNSQGERSFEDLASFALRALSLPISNADVERAFSIMSIVKSKTRNRLLLPMLTALMRIRIHMKVMKICCTNYSPPEHMLKLFNSKMYEVSAKNTVEPNTVETADILVESIDLITDAGDGEDNIYCQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MQC0</accession>
    <name>A0A8J2MQC0_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS10106</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5101033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MQC0"/>
    <dbReference type="OrthoDB" id="6379064at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5101033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="96" mass="10683" checksum="74C2834F0AA4E0CE" modified="2022-05-25" version="1" fragment="single">VIGGEYQERLIPVPYSKSSTDQAIRVVNAFRQGLDSRYGEHSGLTLAEVLRKQSSLSKRHSQTSSIDYADNLPDELTIPEIDVERLSSHSHTETAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MQV0</accession>
    <name>A0A8J2MQV0_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Similar to DDX49: Probable ATP-dependent RNA helicase DDX49 (Homo sapiens)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HICCMSTLAB_LOCUS11646</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the DEAD box helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5103711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MQV0"/>
    <dbReference type="OrthoDB" id="10261904at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050079">
        <property type="entry name" value="DEAD_box_RNA_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959:SF24">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE RHLE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 5 9" id="KW-0347">Helicase</keyword>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="7">
        <location>
            <begin position="1"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="8">
        <location>
            <begin position="138"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="347"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="351"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="367"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAG5103711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="388" mass="43999" checksum="A34021DEBF69D8C6" modified="2022-05-25" version="1">MNFKFQIGEQFTAIGKPINLKTCVVLGGMDMMTQAQELSKRPHIVVATPGRLADHLESCDTFSLNKLKFVVLDEADRLLGGDFDEQIKTIFSALPKQRQSLLFSATMTDALEQVKQVARNNVFQFEDNDHSGMATVQQLDQRYVVCPRDVRDAYLVEVIRTFKGINPSGSIMIFTDTCKNCQLLSMTFNTVGFENVALHAMIKQRERLSALNKFKSNCVKILIATDVASRGLDIPLVELVINHTIPNVPKEYIHRVGRTARAGRGGMSISLITPHDIKLLHAIEELIGTKLQEFKVDEKEIATIFTQVSTTKREAEIVLDETDFYEKKMINKRKKLMMEGKTDEEIDKILAPKKKHSKKDKKIKPIKTSDEIKEDENKLTDEIENNNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MR85</accession>
    <name>A0A8J2MR85_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Translation initiation factor eIF2B subunit gamma</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">eIF2B GDP-GTP exchange factor subunit gamma</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HICCMSTLAB_LOCUS11963</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Acts as a component of the translation initiation factor 2B (eIF2B) complex, which catalyzes the exchange of GDP for GTP on the eukaryotic initiation factor 2 (eIF2) complex gamma subunit. Its guanine nucleotide exchange factor activity is repressed when bound to eIF2 complex phosphorylated on the alpha subunit, thereby limiting the amount of methionyl-initiator methionine tRNA available to the ribosome and consequently global translation is repressed.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the translation initiation factor 2B (eIF2B) complex which is a heterodecamer of two sets of five different subunits: alpha, beta, gamma, delta and epsilon. Subunits alpha, beta and delta comprise a regulatory subcomplex and subunits epsilon and gamma comprise a catalytic subcomplex. Within the complex, the hexameric regulatory complex resides at the center, with the two heterodimeric catalytic subcomplexes bound on opposite sides.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eIF-2B gamma/epsilon subunits family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5104360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MR85"/>
    <dbReference type="OrthoDB" id="10250549at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005851">
        <property type="term" value="C:eukaryotic translation initiation factor 2B complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002183">
        <property type="term" value="P:cytoplasmic translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04198">
        <property type="entry name" value="eIF-2B_gamma_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04652">
        <property type="entry name" value="LbH_eIF2B_gamma_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051960">
        <property type="entry name" value="eIF2B_gamma"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056729">
        <property type="entry name" value="GMPPB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45989">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45989:SF1">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25087">
        <property type="entry name" value="GMPPB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 12" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nucleotidyl transferase" evidence="10">
        <location>
            <begin position="9"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="Mannose-1-phosphate guanyltransferase C-terminal" evidence="11">
        <location>
            <begin position="357"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00044196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00044229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00045373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00046432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF25087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAG5104360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="455" mass="50723" checksum="1E5739429A58DAEF" modified="2022-05-25" version="1">MTKYTEFQVVVLAGGKGSRMTELTAGKTKCLLPIHNVPMIWYSLKSLENAGFTEAIVIVIENTKKEITAALDKLNLNIKLELVGIPESEDLGTADAVRYIHDKIHKDFIVVSCDLIADINIPEVLNLYRRNKASITAVMFPLPKIPLTFVVPGPKSKQKPETDLIGIDNKTNRLVFLASASDFEEDLYISQKLLQKHTNFTMHSKLLDAHFYVISKWVLDFLVHNKSFGTLKGELFPYIVKKQLSRPPKPSVVDDKNASVVKMDLKDDIYRFAVESKLDTLIRKMSAFNDHDSDLDNAYHDDIIRCYAYMIPNNGGLRANTVQMYSFANSMTSGFIPSNVSLPVISSLSTVKSTQISNCNVDEGALIDEKTSVKDSHIGPASIIEPKTRVSNCVIMGNVTIKERCVVQNCILCNGCIVEEGCELKDCLVGTEHVVRGGSNHSREVLTESDRFMEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MRD3</accession>
    <name>A0A8J2MRD3_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Chitin-binding type-2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HICCMSTLAB_LOCUS11072</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5102552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MRD3"/>
    <dbReference type="OrthoDB" id="6020543at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.140.10">
        <property type="entry name" value="Chitin binding domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002557">
        <property type="entry name" value="Chitin-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036508">
        <property type="entry name" value="Chitin-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051940">
        <property type="entry name" value="Chitin_bind-dev_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23301">
        <property type="entry name" value="CHITIN BINDING PERITROPHIN-A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23301:SF0">
        <property type="entry name" value="CHITIN-BINDING TYPE-2 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01607">
        <property type="entry name" value="CBM_14"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00494">
        <property type="entry name" value="ChtBD2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57625">
        <property type="entry name" value="Invertebrate chitin-binding proteins"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50940">
        <property type="entry name" value="CHIT_BIND_II"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0147">Chitin-binding</keyword>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035298362" description="Chitin-binding type-2 domain-containing protein" evidence="7">
        <location>
            <begin position="19"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="8">
        <location>
            <begin position="23"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="8">
        <location>
            <begin position="137"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="8">
        <location>
            <begin position="213"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="8">
        <location>
            <begin position="326"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="8">
        <location>
            <begin position="410"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="273"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="279"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAG5102552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="501" mass="55490" checksum="C0ED30D3EC4E9EEB" modified="2022-05-25" version="1">MSRFIIILLIVFCGGTTALKECIGKCPLQTPINSSIIFLAHINCSKYCVCDHGRPIEMPCPANLHFSLEFNTCADPEQANCTDLTSTPITSQVTQDPENPPKMQSKKLYLNSRPGIRYNTYCANQLTDCHDKALNCIGDCPSNELPQIHLLAHEDCTKFCRCNDTVPWTKDCPEGFHFSLEDGMCLEPEEAQCDRVNGIISTLGPPNVSNECASECPVYSNPDLIVLVAHELCDKYCHCKNGIAEVKNCPLHLQFSLPHGTCVDPNQAQCFNNNGTVTPPTPKPSTPPTPKPTTPPTPPTPKPTTPKPPTPPTAIPPEKPDNSGCIGTCPLNNNPVHTSQLPHINCTKFCKCDWGKPTVMLCPHSLHYNPIIEVCDYPESAGCTGNQKDLPKIEFTRNYRKQNASTADCVKPCPLTNPQNETVHVAHKDCTKFCKCSFGNAWVMDCPKDLYFNPKEQVCDFKFNVHCDESGPWVEEINGNDIDQSQTNNSILYKFKHLFGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MRR4</accession>
    <name>A0A8J2MRR4_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to LZIC: Protein LZIC (Gallus gallus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS11949</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CTNNBIP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5104332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MRR4"/>
    <dbReference type="OrthoDB" id="10262856at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008013">
        <property type="term" value="F:beta-catenin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.490">
        <property type="entry name" value="Beta-catenin-interacting ICAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009428">
        <property type="entry name" value="ICAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036911">
        <property type="entry name" value="ICAT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040065">
        <property type="entry name" value="LZIC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16505">
        <property type="entry name" value="PROTEIN LZIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16505:SF8">
        <property type="entry name" value="PROTEIN LZIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06384">
        <property type="entry name" value="ICAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81730">
        <property type="entry name" value="beta-catenin-interacting protein ICAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-catenin-interacting ICAT" evidence="2">
        <location>
            <begin position="37"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5104332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="117" mass="13225" checksum="9522BF8CF5189183" modified="2022-05-25" version="1">MQLATQAAISAAFKTPAVIRMFGKKEPKLLRERLSLIERDAKLGKLSKEASDRQRVEVLTALKHLGETLSQSELELIQRLTLDNIDTTDFIQVSDYKEKSQVARAIVSQEVKDNKKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MRZ8</accession>
    <name>A0A8J2MRZ8_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Similar to Es2: Splicing factor ESS-2 homolog (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HICCMSTLAB_LOCUS11362</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ESS2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5103143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MRZ8"/>
    <dbReference type="OrthoDB" id="19679at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019148">
        <property type="entry name" value="Nuclear_protein_DGCR14_ESS-2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12940">
        <property type="entry name" value="ES-2 PROTEIN - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12940:SF0">
        <property type="entry name" value="SPLICING FACTOR ESS-2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09751">
        <property type="entry name" value="Es2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="107"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="436"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="111"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="128"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="448"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAG5103143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="483" mass="54739" checksum="C2583251A42BEECA" modified="2022-05-25" version="1">MSSPIVTPGSQALEAIKNIKDLAVFKKPLGPARRSKKFRPKTLDEDTYIEKMGEIIQRDFFPHLEKLKAQNDYLDAIEQNDAKKMRDLYTKYSSGQPLTERITSPATFETPLREDTNNLTKNNKDSQHCSTTGENTTDNKTQVMGLDVYLSTHTSEDNASFEEMMEEANKRQRIKYAWLYKMEENSQAPSLNANENTLSITDSKSSKPLMLDTWNYRNKNYIMYIPDGVELTPEEKIEMAKRKQEIIHSNTRLNTNPFNEKHNKETLNELAKSQLKVYDGKIGVDGKEVIRNLTPKVNGFSFVATPSPRPEDCESPLMTWGEIEGTPFRLDGGDTPILRSNQGPSFRMAEPPKREKLALQLAEKAGERHRDRKSKALEAARKSFATPSPRCLSTIDRLSTMSPAARRLATQKLRIVGTPSPRRTLLRSPSIGVKTHSLSHRATPNHTSLKEVHSDGTSKSKDTILTDNLLNLPQRQRASDFFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MTM2</accession>
    <name>A0A8J2MTM2_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mediator of RNA polymerase II transcription subunit 30</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Mediator complex subunit 30</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HICCMSTLAB_LOCUS13646</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Mediator complex subunit 30 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5109010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MTM2"/>
    <dbReference type="OrthoDB" id="10067025at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021019">
        <property type="entry name" value="Mediator_Med30_met"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31705">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31705:SF4">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11315">
        <property type="entry name" value="Med30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0010">Activator</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="111"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="79"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="111"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAG5109010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="297" mass="33727" checksum="325A0EDE56F66C44" modified="2022-05-25" version="1">MAGQQQSFLPGYPAAHQQAMINQFGGGQIAPELMGPQQRGMSSGMMNPQQFGAGMGGNVGSSPMAQQVMTQERQQLAQQTLMQQQLQQMQQQKRQLQQQQQTALISQNNQAVNQVQAPQPSVPQMQPQVPQQQQPQSQQPRQQEFSPVAICKKGQETVQKITLAVQELYQMLKNIQPPTGPHQGFATAVESKKSVKIALTNICTLCTHLRRIYNLCNENSQLQGMEYTHIESLIPFKGEWDMKSDEKKTSEVYRHVCEERNQLIEQLTIKNRQLKEIIDHIRLITSEINIMLHMRRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MXU9</accession>
    <name>A0A8J2MXU9_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS11088</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5102584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MXU9"/>
    <dbReference type="OrthoDB" id="7526931at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006631">
        <property type="entry name" value="DM4_12"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07841">
        <property type="entry name" value="DM4_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5102584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="134" mass="15732" checksum="61861EBFD6EA35EB" modified="2022-05-25" version="1">MIFRWQYRLNYKIASVGWTTIFNQASGFKVSWHLPDGTNTKQKRSIYDLHDDIKFLYQSHGLNGQSCLARNICEAMRYAKREDGVMAKILKLLARTSNTNCTNCTDEKDFEVECHRYTRRCPLQLISIDDFSEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MZ78</accession>
    <name>A0A8J2MZ78_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Enolase</fullName>
            <ecNumber evidence="3">4.2.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">2-phospho-D-glycerate hydro-lyase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">2-phosphoglycerate dehydratase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">HICCMSTLAB_LOCUS13780</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="12">Mg(2+) is required for catalysis and for stabilizing the dimer.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 4/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the enolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.11" evidence="3"/>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5109144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MZ78"/>
    <dbReference type="OrthoDB" id="1739814at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00187"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000015">
        <property type="term" value="C:phosphopyruvate hydratase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004634">
        <property type="term" value="F:phosphopyruvate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd03313">
        <property type="entry name" value="enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.390.10:FF:000001">
        <property type="entry name" value="Enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.120:FF:000002">
        <property type="entry name" value="Enolase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.120">
        <property type="entry name" value="Enolase-like C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.10">
        <property type="entry name" value="Enolase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00318">
        <property type="entry name" value="Enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000941">
        <property type="entry name" value="Enolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036849">
        <property type="entry name" value="Enolase-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029017">
        <property type="entry name" value="Enolase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020810">
        <property type="entry name" value="Enolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020809">
        <property type="entry name" value="Enolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020811">
        <property type="entry name" value="Enolase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01060">
        <property type="entry name" value="eno"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11902">
        <property type="entry name" value="ENOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11902:SF1">
        <property type="entry name" value="ENOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00113">
        <property type="entry name" value="Enolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03952">
        <property type="entry name" value="Enolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001400">
        <property type="entry name" value="Enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00148">
        <property type="entry name" value="ENOLASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00002">
        <property type="entry name" value="enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00178">
        <property type="entry name" value="enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00001">
        <property type="entry name" value="Enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01192">
        <property type="entry name" value="Enolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01193">
        <property type="entry name" value="Enolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51604">
        <property type="entry name" value="Enolase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54826">
        <property type="entry name" value="Enolase N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00164">
        <property type="entry name" value="ENOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="7" id="KW-0456">Lyase</keyword>
    <keyword evidence="5 12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enolase N-terminal" evidence="14">
        <location>
            <begin position="3"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="Enolase C-terminal TIM barrel" evidence="13">
        <location>
            <begin position="142"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="10">
        <location>
            <position position="210"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10">
        <location>
            <position position="344"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="158"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="167"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="245"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="294"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="294"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="319"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="319"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="371"/>
            <end position="374"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="395"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR001400-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR001400-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR001400-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM01192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM01193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CAG5109144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="434" mass="46896" checksum="A3ECB3967B23D0A0" modified="2022-05-25" version="1">MPIQSIKARQIYDSRGNPTVEVDLVTENGLFRAAVPSGASTGVHEALELRDNDKSKYHGKSVFKAVDNINSIIAPELLKAGLEVTQQTDIDNFLLKLDGTPNKAKLGANAILGVSLAVCKAGAAKKGIPLYKYIAELAGNKDIILPVPAFNVINGGSHAGNKLAMQEFMILPVGAANFTEAMKMGSEVYHHLKNGIKKKFGLDATAVGDEGGFAPNILENKEALNLIIDAIKTAGYEGKIKIGMDVAASEFHKNGKYDLDFKNEKSDPATYLEPDALKNLYLDWVKDFPIVSIEDPFDQDGWDSWTSITASTPIQIVGDDLTVTNPERIKTAIEKKACNCLLLKVNQIGSVTESINAHNLAKSAGWGTMVSHRSGETEDTFIADLVVGLSTGQIKTGAPCRSERLAKYNQILRIEEELGANAKFAGEKFRHPTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2N011</accession>
    <name>A0A8J2N011_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS13162</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5108287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2N011"/>
    <dbReference type="OrthoDB" id="9049620at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5108287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="102" mass="11338" checksum="574E33F51B9BDB4C" modified="2022-05-25" version="1">MSESTKTSSTTTTKTALTAGRRRKRAQQTTTNSRSPSPDTYIDLTVDSPVLPRQRKQSSTNKSQPTRNNIEILDNTIIIDDTDTSPARFRKKCPVCMAPLIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-24" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>B9W4K8</accession>
    <name>B9W4K8_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Cc_27b</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">Cc50C22.7</name>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS5452</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2009" name="Science" volume="323" first="926" last="930">
            <title>Polydnaviruses of Braconid Wasps Derive from an Ancestral Nudivirus.</title>
            <authorList>
                <person name="Bezier A."/>
                <person name="Annaheim M."/>
                <person name="Herbiniere J."/>
                <person name="Wetterwald C."/>
                <person name="Gyapay G."/>
                <person name="Bernard-Samain S."/>
                <person name="Wincker P."/>
                <person name="Roditi I."/>
                <person name="Heller M."/>
                <person name="Belgahzi M."/>
                <person name="Pfister-Wilhem R."/>
                <person name="Periquet G."/>
                <person name="Dupuy C."/>
                <person name="Huguet E."/>
                <person name="Volkoff A.N."/>
                <person name="Lanzrein B."/>
                <person name="Drezen J.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5089993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FM212911">
        <property type="protein sequence ID" value="CAR82245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B9W4K8"/>
    <dbReference type="OrthoDB" id="7647200at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5089993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAR82245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="238" mass="27900" checksum="CE2C09DC2B03AFD0" modified="2009-03-24" version="1">MAYQESVDELLSDALSFNNEIKTCNTIHNLQCNDEFIRLSGHFIPTIYGVKTITIPQIINTVIKSENSFEKAKYLMKNISVIKNSYLDKLKTVLSKIYPMIVVNLNRYHTLRKIYDYEIKQIDPKPLMQQSIFAEIFNIAFQHIGHDIKDPKDLYRLLTLLSEPLDWVDYYNIIKKYCHINFMMYKINLPTAKLFVHNADILSTPLVLLRYTNSKVIDLVHVYEHGHNLFQGGYKFNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-10-16" modified="2023-09-13" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>S6D4U1</accession>
    <name>S6D4U1_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Cc_single_35.3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">CcBV_35.3</name>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS6214</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Philos. Trans. R. Soc. Lond., B, Biol. Sci." volume="368" first="20130047" last="20130047">
            <title>Functional endogenous viral elements in the genome of the parasitoid wasp Cotesia congregata: insights into the evolutionary dynamics of bracoviruses.</title>
            <authorList>
                <person name="Bezier A."/>
                <person name="Louis F."/>
                <person name="Jancek S."/>
                <person name="Periquet G."/>
                <person name="Theze J."/>
                <person name="Gyapay G."/>
                <person name="Musset K."/>
                <person name="Lesobre J."/>
                <person name="Lenoble P."/>
                <person name="Dupuy C."/>
                <person name="Gundersen-Rindal D."/>
                <person name="Herniou E.A.Drezen.J.M."/>
            </authorList>
            <dbReference type="PubMed" id="23938757"/>
            <dbReference type="DOI" id="10.1098/rstb.2013.0047"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5092545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="HF586473">
        <property type="protein sequence ID" value="CCQ71265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S6D4U1"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5092545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCQ71265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="66" mass="7875" checksum="741D87A0E53B77C7" modified="2013-10-16" version="1">MSQEKDMEPLAEQFHEAKLLRSLDFEIANFTGSNSLKSYTISMKIYDDPTRRVWNVEIYKFVLDKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2E6N4</accession>
    <name>A0A8J2E6N4_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Exosome complex component RRP45</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Exosome component 9</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HICCMSTLAB_LOCUS1439</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RNase PH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001116">
        <property type="protein sequence ID" value="CAG5075285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2E6N4"/>
    <dbReference type="OrthoDB" id="10264038at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000177">
        <property type="term" value="C:cytoplasmic exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035925">
        <property type="term" value="F:mRNA 3'-UTR AU-rich region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000467">
        <property type="term" value="P:exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071028">
        <property type="term" value="P:nuclear mRNA surveillance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071035">
        <property type="term" value="P:nuclear polyadenylation-dependent rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016075">
        <property type="term" value="P:rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071038">
        <property type="term" value="P:TRAMP-dependent tRNA surveillance pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034473">
        <property type="term" value="P:U1 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034475">
        <property type="term" value="P:U4 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034476">
        <property type="term" value="P:U5 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11368">
        <property type="entry name" value="RNase_PH_RRP45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.70">
        <property type="entry name" value="GHMP Kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001247">
        <property type="entry name" value="ExoRNase_PH_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015847">
        <property type="entry name" value="ExoRNase_PH_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036345">
        <property type="entry name" value="ExoRNase_PH_dom2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050590">
        <property type="entry name" value="Exosome_comp_Rrp42_subfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027408">
        <property type="entry name" value="PNPase/RNase_PH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033100">
        <property type="entry name" value="Rrp45"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11097:SF14">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT RRP45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11097">
        <property type="entry name" value="EXOSOME COMPLEX EXONUCLEASE RIBOSOMAL RNA PROCESSING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01138">
        <property type="entry name" value="RNase_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03725">
        <property type="entry name" value="RNase_PH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55666">
        <property type="entry name" value="Ribonuclease PH domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Exoribonuclease phosphorolytic" evidence="10">
        <location>
            <begin position="31"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="domain" description="Exoribonuclease phosphorolytic" evidence="11">
        <location>
            <begin position="189"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="320"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="378"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="320"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="335"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF03725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAG5075285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="426" mass="47673" checksum="0691785B3A949B37" modified="2022-05-25" version="1">MKEVLITKCEKKFINTALDENIRLDGRKLNEARKLKLHFGSSWGSCLASLGQTRVIANVSCDIQQPKLSRPNEGLLYINVELNPLAAAHFEAGRQSEVGVALTRQLERCFKDSRCLDMESLCIVADKKVWNIRVDINVINHDGNLVDCASIATLAALSHFHRPDVTSTGDDVIIHSFAEKDPLPLTLFHQPVCVSFSTFENGKTIMDPTYIEERLGVTQLTMGLNAYHEFVNLSFADKSSLSKISTDVSASVKSIAANHAINVIKQIRDAVTLDVQTRYKKEPCKINRFKDAISSDKISMFREKMPIKLSQWNTRIKEEEAQKKYPKMDCNDENDHNDDNDDDEDNDVEMDESGDEVRKVGLRSAELITKMSTSVGEGLKNSWVSSSDDEDDDGTSANDIETLKVTKVNKVLGEIVLTDSEQEDIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2E7Y1</accession>
    <name>A0A8J2E7Y1_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS2244</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001117">
        <property type="protein sequence ID" value="CAG5076658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2E7Y1"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="238"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5076658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="257" mass="28402" checksum="5882A0B0C822F2DB" modified="2022-05-25" version="1" fragment="single">NLKKNENYLLGIFVGTQTSVNNTCSWIFTAFACFKKGPEVSKNKNSTPAVLGLEPGGCKHSTRPVYILKINTIAFALKKSYQGLFFPGFRHVEVELVSRSFELDFPDVCHQLRVVHRDTSEAAASLQINSKAIAEEKAARNAKQGATLRIQLFFCVLPRDIEVIGNGAVFPATEGITGPNPAILKDLLPTSFEFLPDNIPASTALYSATRVSFDKKLLLMKIKFERTQIVKKNTDCKTMQDRTTSTGQHLEHGTHAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2ED50</accession>
    <name>A0A8J2ED50_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS1348</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001116">
        <property type="protein sequence ID" value="CAG5075194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2ED50"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="73"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5075194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="140" mass="15533" checksum="F66A9CD0AEE828C6" modified="2022-05-25" version="1">MIVFEVMRNFVEWLSKNHAHETKESLGADMSVVHCRLFASANMPRSIRNDFSKRKRELEEALKAYNSRVAEEKQNVPSQLQLQPVIPTKQSQDLTAAGSGETETAKPEELHLSGCGSSKFNVVSCPPSNSGILFGQILKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2EDC3</accession>
    <name>A0A8J2EDC3_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Histone deacetylase complex subunit SAP30 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">HICCMSTLAB_LOCUS1440</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SAP30 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001116">
        <property type="protein sequence ID" value="CAG5075286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2EDC3"/>
    <dbReference type="OrthoDB" id="510958at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000118">
        <property type="term" value="C:histone deacetylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1800.30:FF:000001">
        <property type="entry name" value="Histone deacetylase complex subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1800.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024145">
        <property type="entry name" value="His_deAcase_SAP30/SAP30L"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038291">
        <property type="entry name" value="SAP30_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025718">
        <property type="entry name" value="SAP30_Sin3-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025717">
        <property type="entry name" value="SAP30_zn-finger"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13286:SF6">
        <property type="entry name" value="HISTONE DEACETYLASE COMPLEX SUBUNIT SAP30L-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13286">
        <property type="entry name" value="SAP30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13867">
        <property type="entry name" value="SAP30_Sin3_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13866">
        <property type="entry name" value="zf-SAP30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0678">Repressor</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Histone deacetylase complex subunit SAP30 zinc-finger" evidence="13">
        <location>
            <begin position="15"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="Histone deacetylase complex subunit SAP30 Sin3 binding" evidence="14">
        <location>
            <begin position="106"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="77"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="88"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00073392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF13866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF13867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CAG5075286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="175" mass="20006" checksum="5D7104632B538A61" modified="2022-05-25" version="1">MNGFSTGEEDSRGASDQICCLVDEGERCSRPAGNASYSKRIQKTVTQRRLKLNLDHVARHIYICDFHKQVILCARSKQQQQRRRKDSEEDSGETDNDVPDVDLFQLQVGTLRRYKRHYKVQTKPGLNKAQLADTLMKHFKTIPVSEKEVSSIFIYTVKTNANKLDQKNGVNSDTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2EDP3</accession>
    <name>A0A8J2EDP3_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS2157</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001117">
        <property type="protein sequence ID" value="CAG5076350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2EDP3"/>
    <dbReference type="OrthoDB" id="8197438at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="51"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="99"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="298"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="380"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="477"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="544"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="620"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="75"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5076350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="794" mass="92478" checksum="DE64BC7125B7498E" modified="2022-05-25" version="1">MSRLNLTEPIDKADDKILYLPKASRSVSNHGRNTSGTRARSKIPMIVTQNTAADTSQMSPAKEMTSPPSVWGNRSRMTSRSFNSSPSKTRASSFSAANQRILERQYKNKQNRYMSIRNEIQEKQLSALNIYEEVSQLREKIMAVGGKDPGKIESIKSISGDFSVKINENYNNNDNNNNNNNNRGSATINSSINKEFASTLLNELEDYPKGCLTLCEDAINKHSELIKSIDNLKLNHNEDKLGEFFLKQLDDWKTETESFKVRLEMTKKSIEESKSEMTNKVKAMWEEIDCSRFKIRELETMSNEVVDKLRKKIEAEAEKFNQLKETKDVTDNDLRKTKAVVQELEARIQSDEINIIKSQEYVKSLKSELHQNDKIFENRTRDLNNSLKNAEETIENLENQRSELEASLIELQDKLEEVQLERDEAIQEARKRIEEDEEFYKSSQVEKLNCEIASLNKELITCKDFISGINDRKLSSDRDLECQLEEERARIKDLTQDYQSLQRTFETTQARMIDLEQQVASMYGGDLKDVPKDGFQALEVLKINEELGQEIADLRRKNIELDSSLAEAVNKFHQRDQQVHEQAAQIRVLDQMIVYLKNKTHGISDDQEVTKEISTNTEAIQKLYEMVDTKELQLTRLEKLVKQMEDQEERAQEQRTRLERRIAQLELALQTKNNKDPRYADYSIYEQVFQAVPSSPRFLDPQPKPRTPEYVYNTRLVQEEVARTLELERKYQKYKQKSQHIECFYNWMLERSPNFGDLNTSEDYHSRNRYPNPTVPHIDVSSYAYQERFQCGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2EI25</accession>
    <name>A0A8J2EI25_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Spondin-1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">F-spondin</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HICCMSTLAB_LOCUS2158</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Extracellular space</location>
            <location evidence="1">Extracellular matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001117">
        <property type="protein sequence ID" value="CAG5076352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2EI25"/>
    <dbReference type="OrthoDB" id="347314at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08544">
        <property type="entry name" value="Reeler"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2130">
        <property type="entry name" value="F-spondin domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.4060">
        <property type="entry name" value="Reeler domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.100.10">
        <property type="entry name" value="Thrombospondin type-1 (TSP1) repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002861">
        <property type="entry name" value="Reeler_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042307">
        <property type="entry name" value="Reeler_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051418">
        <property type="entry name" value="Spondin/Thrombospondin_T1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009465">
        <property type="entry name" value="Spondin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038678">
        <property type="entry name" value="Spondin_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000884">
        <property type="entry name" value="TSP1_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036383">
        <property type="entry name" value="TSP1_rpt_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11311">
        <property type="entry name" value="SPONDIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11311:SF16">
        <property type="entry name" value="SPONDIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02014">
        <property type="entry name" value="Reeler"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06468">
        <property type="entry name" value="Spond_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00090">
        <property type="entry name" value="TSP_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00209">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82895">
        <property type="entry name" value="TSP-1 type 1 repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51019">
        <property type="entry name" value="REELIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51020">
        <property type="entry name" value="SPONDIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50092">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="3" id="KW-0272">Extracellular matrix</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035230354" description="Spondin-1" evidence="8">
        <location>
            <begin position="21"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="domain" description="Reelin" evidence="9">
        <location>
            <begin position="8"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="Spondin" evidence="10">
        <location>
            <begin position="50"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="351"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="491"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="355"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="505"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="518"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="544"/>
            <end position="590"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00019594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00030964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAG5076352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="600" mass="67143" checksum="264D7D023AD50C54" modified="2022-05-25" version="1">MIYAACFVFFILTGVKESLAGKCDRKIDSGTAPSVHDGKFFITLWTFNKTDTVDQYMPNTRYIVTLEGTKLQHTVSQDSAGYREKFTRFILTADNKNDSSTVEGTFDLVDEMLTQFSDKCPNSVSETSNIPKEEIAVAWTSPPEGSGCILIRATVMETPDTWYMDDGGVARTICPDPKAIEDDPGPILPTCCACDEAKYEVTFEGLWSRNTHPKDFPSKGWMIRFSDVIGASHTVDYRFWRYDETASEVPSPDWIVGVSGLELCLSNCSWIEHKELNLYPIDAGTDDGITYMSPDSPLEDPEPIKRITTNWPNDTRSPFYDPLGLDMKPMAKLHLSRQRLYEKSCNASLGDSAVDSGGDNNDINNNNNEGSENSTGEEGEGGGEGNKSSEGEPCRTTQWSAWGKCSEPCGEGKRLRQRKYEDPVAAAAHNCNKSDGQEREKTILDTPDCKLSEWGEWSSCTTSCGEGEITRSRIFVHKKHRKRCKLVSNGPELQQTVPCENEPCENTKTEEVSKKEDLDDDVVVDDDEVEEPTEAEEGETHPDEENEEEENDAEGEEGAEGDESEELDSEKEEEMNYQEDDENNPVEVTEEWLQVRINDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2EJK8</accession>
    <name>A0A8J2EJK8_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Similar to Putative AC9 transposase (Zea mays)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HICCMSTLAB_LOCUS1360</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001116">
        <property type="protein sequence ID" value="CAG5075206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2EJK8"/>
    <dbReference type="OrthoDB" id="1271298at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052035">
        <property type="entry name" value="ZnF_BED_domain_contain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481:SF10">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAG5075206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="179" mass="20616" checksum="757A9DFE5A487A06" modified="2022-05-25" version="1" fragment="single">IRDRLYGLYDAVRNKLLSSLNQFPYVSITTDGWSSRANNSFVTITVHGIDDQWNLSSFTLDTLEMLESHNATNTYNHLAKALNDWNLYDKVIAVVHDNARYMVAAVQDSWEADDDIEISVRCFCHTLQCALKEYFVFSNEKNLSGVSGTRITAVRRDTYTQIQLYSNRSTRLFHDKTTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2EMC9</accession>
    <name>A0A8J2EMC9_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS651</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001114">
        <property type="protein sequence ID" value="CAG5073879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2EMC9"/>
    <dbReference type="OrthoDB" id="7693454at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47890">
        <property type="entry name" value="LD24308P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47890:SF1">
        <property type="entry name" value="LD24308P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5073879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="218" mass="25547" checksum="3AF77558DCD361F9" modified="2022-05-25" version="1">MCLSWCKGFRRQCGQILTGVKFELKNLIIHLQIEEGKLLSGGRIDTYSIHMKELEIFEYSTYPKDRLELVIDDELMRLEESVDYIFVKQERRYINLDNVFFREPGYVVTGLKLSVDPENFESLQLAVHITPFDFDSGSLTPTDDKPSKWIIYKYMSDEDRKFENRRLVALQPRIPLEGVSLYYRGKENSAGFVGFRMTTLDIPAYLDPQMSQQDLEFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2GZJ8</accession>
    <name>A0A8J2GZJ8_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Similar to Nudt8: Nucleoside diphosphate-linked moiety X motif 8 (Mus musculus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HICCMSTLAB_LOCUS676</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001114">
        <property type="protein sequence ID" value="CAG5073904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2GZJ8"/>
    <dbReference type="OrthoDB" id="206213at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010945">
        <property type="term" value="F:coenzyme A diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03426">
        <property type="entry name" value="NUDIX_CoAse_Nudt7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045121">
        <property type="entry name" value="CoAse"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12992:SF11">
        <property type="entry name" value="MITOCHONDRIAL COENZYME A DIPHOSPHATASE NUDT8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12992">
        <property type="entry name" value="NUDIX HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0464">Manganese</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="7">
        <location>
            <begin position="62"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG5073904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="239" mass="27472" checksum="B81BCA9A2FF5B637" modified="2022-05-25" version="1">MTIYNCSLFLFRLPYRQFVRKITTLKNASDKLHPNVILTEENKKACISRLKQLRPMKIKDNEKKAAVLVPLCLYNNELGLLYTLRSFKLSTNRGQVSFPGGIQDSEDKSYEETAVRETWEELRLPRDKVEIWSRGNFVGRNDVDVMPVVGFVGEIDPKKLDINSEEVDEAFVVSLKDLCDPDKSGYTYFKKGFLLPAYTGGKHRIWGLTAVITHVIMKTLAPELFVVQLRGLIVRENWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H0I8</accession>
    <name>A0A8J2H0I8_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">IKs producing slow voltage-gated potassium channel subunit alpha KvLQT1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HICCMSTLAB_LOCUS2174</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001117">
        <property type="protein sequence ID" value="CAG5076390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H0I8"/>
    <dbReference type="OrthoDB" id="8879391at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008076">
        <property type="term" value="C:voltage-gated potassium channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005249">
        <property type="term" value="F:voltage-gated potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000056">
        <property type="entry name" value="Potassium voltage-gated channel subfamily KQT member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003937">
        <property type="entry name" value="K_chnl_volt-dep_KCNQ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47735:SF14">
        <property type="entry name" value="POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY KQT MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47735">
        <property type="entry name" value="POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY KQT MEMBER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="301"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="334"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="400"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="434"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="465"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="domain" description="Ion transport" evidence="8">
        <location>
            <begin position="369"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="83"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="161"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="200"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="83"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="117"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="203"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="235"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00032659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAG5076390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="485" mass="56052" checksum="E311A07B00DCB361" modified="2022-05-25" version="1">MLHSVMLGYGPGRGRRDNFPGCHPDRRTRRFRMNRGEQETLFRQSRQLTRIVSSREDLVLSVLKAPISQQQQQQQQQQQSCRHQQYLHSPQEHQNSLPDHQSHHKKCPHQGQTYNERLPKQKSEDQNTRLTEKRYSAAAAYAALQGSEDELVSCDTTEDFALKTPGSETEDTDNGVNTLEDNPTPRKFTFLKRFRSPRFGEAHHKRVPTPMKRKHRRKRSKGDIISRNDPGNDVGGEEEEEEEEEETPIPVQAGVPDPYYPIYLPIDQAFKAKYVFHHKKGKTFQERLYVFLEHPGGWICFVYHFTVFMVVLVCLIFSVLSTIEQYSNFANETLFWMGSEVIFFWFQEICLVVFFGVEYMIRLWSAGCRFLQILRMLHVDRQGGTWRLLGSVVFIHRQELITTLYIGFLGLIFSSYFVYLAEKDAVGPDGKTDFASYADALWWGVITVTTIGYGDTVPQTWMGKIVASCFSVFAISFFALPALIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H3U0</accession>
    <name>A0A8J2H3U0_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Similar to TM7SF3: Transmembrane 7 superfamily member 3 (Homo sapiens)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HICCMSTLAB_LOCUS2131</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001117">
        <property type="protein sequence ID" value="CAG5076300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H3U0"/>
    <dbReference type="OrthoDB" id="5967337at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043069">
        <property type="term" value="P:negative regulation of programmed cell death"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025256">
        <property type="entry name" value="TM7S3/TM198-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042502">
        <property type="entry name" value="TM7SF3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15937">
        <property type="entry name" value="TRANSMEMBRANE 7 SUPERFAMILY MEMBER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15937:SF3">
        <property type="entry name" value="TRANSMEMBRANE 7 SUPERFAMILY MEMBER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25992">
        <property type="entry name" value="Ig_TM7SF3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13886">
        <property type="entry name" value="TM7S3_TM198"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="275"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="301"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="339"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="364"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="domain" description="TM7S3/TM198-like" evidence="6">
        <location>
            <begin position="267"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAG5076300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="491" mass="55091" checksum="937E9D7F1E9C6FDD" modified="2022-05-25" version="1">MVSVMKGKRTSKREKGKWQMANDTFNTSQRNGQAFYIKTTLPSSKATLVLIKNSPSSLSFIIIQAHAQENLTLITKNAQKVSRIAGTNIGLQLDSKLIKDTQINVINDKNKTVPALIAITAYTFKAPVPGGCNMEFDIEVSPYQRLMLTNSTIIIDSQPASAPLINGLKLPCEKNLVTYEIYRLYTDESDFNNETYFSTIIKMLTVDDIIKNAVKIPTSASRSPMRKVYSSYPRTGSAYVMIATFGNHSSAYVPIFSYGCTPFSTEISCDYLKTAMSKVLCASVLFFGIFLTLITRRRYEVELFLLGCFSGGIIGYIILHDNQMEAEYGQLVLVNDTTFWIIYSTIVTAVVLLLCIFSPNSNIICCAFIGAFAIILPIDYWVGSSLKYIIINTVRRITVYGFNVAIIHPPFQSKDIWLSVFWILLALQSIHLQRKRLQGGSPLFPRRVDYNLIDSESSYPIISEEPHHQGTFLIGNNSTITTTKNYSTFFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H523</accession>
    <name>A0A8J2H523_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">mannosyl-oligosaccharide glucosidase</fullName>
            <ecNumber evidence="11">3.2.1.106</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HICCMSTLAB_LOCUS783</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 63 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.106" evidence="11"/>
    <dbReference type="EMBL" id="CAJNRD030001114">
        <property type="protein sequence ID" value="CAG5074011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H523"/>
    <dbReference type="OrthoDB" id="410058at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004573">
        <property type="term" value="F:Glc3Man9GlcNAc2 oligosaccharide glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009311">
        <property type="term" value="P:oligosaccharide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.110">
        <property type="entry name" value="Glycosyl hydrolase family 63, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031335">
        <property type="entry name" value="Glyco_hydro_63_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038518">
        <property type="entry name" value="Glyco_hydro_63N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004888">
        <property type="entry name" value="Glycoside_hydrolase_63"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10412">
        <property type="entry name" value="MANNOSYL-OLIGOSACCHARIDE GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10412:SF11">
        <property type="entry name" value="MANNOSYL-OLIGOSACCHARIDE GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03200">
        <property type="entry name" value="Glyco_hydro_63"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Glycosyl hydrolase family 63 C-terminal" evidence="12">
        <location>
            <begin position="165"/>
            <end position="616"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00038888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF03200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAG5074011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="636" mass="73130" checksum="86506F187FC74A56" modified="2022-05-25" version="1">MDICRDRIPITLNSNDTEPKDSQKSQEISFIFYSALEDKSTGNIKASLGADNRLSGMEGYTDGLGAYRFSMNPTKGTVEEHSFLIAVLPGLNLVKETILQNLRLASQKVSNVKRIVLGGDQLPLDNEGKKTDPNFCATQVTARVPFEFEVLFESGSVPLRKEKLTGKNFDLALGEQRKRFNDKFEKIFKLTEKGFKEDAIEFAKYGFSNLIGSIGYFYGSSQVQSVHTKSPVPYWKAPLYTGVPSRSFFPRGFLWDEGFHGLLVATWDLDIEMDIMSHWFDLMNSEGWIPREMILGSEALAKVPEEFVTQISTNANPPTFFLTLQYILNSRESELLDRHYKLLDKLYPRLQAWFEWFNTTQVGDLPGTYRWRGRDSLTNRELNPKTLTSGLDDYPRASHPNVDERHVDLRCWIAFAAGVMARLSELLHHPADKYRDTHRFLTDNQVLNGLHWSPSSQSYADYGLHTDKVELRRPSAPPRSPASPELIRVVLEDPSLKFVDSSFGYVSLFPFILQVVEPDSPHLEKILMDLTKPELLWTKFGLRSLAKNSPLYAKYNTEHDAPYWRGPIWINLNYLTLRALNWYAETPGPYAGKAKKIYKDLRENLIKNMLVQYKKNWVHLGKLWRCLWRRKRQSSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H5K6</accession>
    <name>A0A8J2H5K6_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="12 15">Leishmanolysin-like peptidase</fullName>
            <ecNumber evidence="15">3.4.24.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">HICCMSTLAB_LOCUS1027</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="14 15">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="14 15">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the peptidase M8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="15"/>
    <dbReference type="EMBL" id="CAJNRD030001114">
        <property type="protein sequence ID" value="CAG5074338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H5K6"/>
    <dbReference type="OrthoDB" id="527990at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.55.10:FF:000001">
        <property type="entry name" value="Leishmanolysin like peptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.132.10:FF:000001">
        <property type="entry name" value="leishmanolysin-like peptidase isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.132.10">
        <property type="entry name" value="Leishmanolysin , domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.55.10">
        <property type="entry name" value="Leishmanolysin domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.34.10">
        <property type="entry name" value="Leishmanolysin domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001577">
        <property type="entry name" value="Peptidase_M8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10942">
        <property type="entry name" value="LEISHMANOLYSIN-LIKE PEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10942:SF0">
        <property type="entry name" value="LEISHMANOLYSIN-LIKE PEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01457">
        <property type="entry name" value="Peptidase_M8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 14 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 14 15" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="7" id="KW-0498">Mitosis</keyword>
    <keyword evidence="5 15" id="KW-0645">Protease</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 14 15" id="KW-0862">Zinc</keyword>
    <feature type="active site" evidence="13">
        <location>
            <position position="169"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="168"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="172"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="275"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="16">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00039717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR601577-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR601577-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU366077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CAG5074338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="598" mass="68295" checksum="63D06DC8DF6017F2" modified="2022-05-25" version="1" fragment="single">CFRLDAEKFDLINNTILPEAVHFWERTLMVRETKNTIRLNRKCESSRVFVKDHHTYCIDTCRAVTMCGEVVVPEEHLDVCRVCNATGQKCQVQDDSIAGAGIDGADFVFYVSALQSERCHNGLTVAYAAHCQQEAALDRPIAGHANLCPGSISTKPQELETLLSTVKHEILHALGFSLSLYAFYRDENGEPRTPRRSETGKPQLNEKLQTHQWSENTIRTVVRPQWHVRGGTVNRSMQMIVTPRVQEEVRAHFKCPSLEGAELEDQGEDGTALTHWEKRVFENEAMTGTHTQNPVYSRITLALMEDTGWYTANYSMAQELGWGRRLGCDFAMKSCKEWITSRSSRLSEENPKGKTIHPFCNKVKQDPLQTECTDDRSSVALCNLVEHSQPLPKKYQNFDWIPHVLPGKEQYYGGSVSLADYCPYIQEFTWRAKNIVIRGSHCLYEENNPHPEKNFALENYGPYSRCFDHTNDMWEERTCKQARQWQHWGSGCYQYKCEAGRLHIMVANFTYTCYHAGQKLTIKIIQNEWLHKGALICPPCKEICQQELKAKGEWCKPGDEHPPSTFYHQDHLQCSAVGNLPVILLTVGTTVLSSVILR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H5Z0</accession>
    <name>A0A8J2H5Z0_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to FAM193A: Protein FAM193A (Homo sapiens)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS2497</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001117">
        <property type="protein sequence ID" value="CAG5077554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10044608at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029717">
        <property type="entry name" value="FAM193"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15109">
        <property type="entry name" value="AGAP004327-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15109:SF3">
        <property type="entry name" value="PROTEIN FAM193B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="108"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="547"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="625"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="765"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="843"/>
            <end position="886"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1001"/>
            <end position="1334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1416"/>
            <end position="1466"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="907"/>
            <end position="941"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="33"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="113"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="135"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="547"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="634"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="707"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="765"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="843"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="864"/>
            <end position="883"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1016"/>
            <end position="1030"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1038"/>
            <end position="1047"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1057"/>
            <end position="1073"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1081"/>
            <end position="1095"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1130"/>
            <end position="1149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1151"/>
            <end position="1167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1169"/>
            <end position="1194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1213"/>
            <end position="1222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1223"/>
            <end position="1232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1240"/>
            <end position="1260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1267"/>
            <end position="1283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1293"/>
            <end position="1329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1443"/>
            <end position="1461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5077554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="1619" mass="178568" checksum="FBD8CCCCCC521DC7" modified="2022-05-25" version="1">MSGSDDKESQCEERTTESNNEIMGDVLAKEAEESGDAVDAGDVENNIKVDADADNQTQVDVKTQFEIDAQPNQDNDNYRDETTDSEDESHFRNSPCEADAAPEIPVAQSIPESTSTDTQTTQTTNDIWNLSKSLDDDDDDDDDDNEELSSYFGQTQTIKHEKVCTCEVCVVQRAFIRDKITKVWNWQSQGLKIREYIRAVFNAAIESPCVPNIRKYECDPNQYAQLREIVNDLVKSHPHKFFLMLVIQAQEFVVELKIRIMRPLQDDNLARIAEVFLTTTAAQVTDLIKPLEDNHLSKFTITWEFFNKKLYQNYIYFYEPTIRNILPSLVRQLRKPRKGKGYKVLLERYLGFVDEMMQIADLWLDKELNIDKYNAVQTRRIIDKRKASTPWTLYTIEEATKVENERTLDVPGLGLNQTPFDSYFIKLLERLESPPDTALVRKMLDAWSKQAYQTLALSSLGIYWHKEREIAGDGTTPDDPGYYFGYQAAAWLVLSRATDTTLEIDTKCTVCGELAWVSHLVVGGRTKTGQCAHPTLKANGDISTASLSVSLPGSPSSTGSAADSTELVNTNHNTDNKKRKGCLCTYRHLGEWQGSTFRGLLLFPPCLCMLNMRQLPESACPCVREEPSRLSGRNNNNNSSNNSNSGSNCSNNINNNSNNSCNKTSDQQISTQSSSVESGETIKMNNCKPVVPQTRHSTTQTPNGMHPHNHGHAHNNHTGHNPHPRCTGHGSDIKGIAKHNHGHPHCHKQTVEQIRRVSCNSLHTGDGNCSDSGSIEDSCSTGGSSSPRDAGRHCDCCYCEVFGHGVPSVAPVSRNYNETRERLRQLLTKKKAKKCNKVTGSTIVGSGSTAATSSSCSPPVSPADTPSDNSVTRGRSDTPSTVSELRDDRDLDTLIKFIEGDVDSSGKKDTKKSEKKARQKLKKAEEALRLQKEEADRQKIVELQKKTPGVTITVVDPKKPAQKLLMNKNLPEVSILPATVQKKIVKNEVREKVKETVVVVASGKSKKKKKQKIVEPEPEPEPEPEPEPEPEPVPLTKKERKKLKKEMKKMELQKLQNSSDGNSGKVSKDQPQIVTIKRVMESNNAEPTVTITLKGQTPAEDKVLFTLVNGQTKEPSKETGGKKKKKKKGQAQAQVQAQTQVKVTQVQAKSSNKEKDKGKTKKEEKKKAQALAKIQDQDQGQLQGNKGQNQAQAQVSSEIKTKKKDKKNAENKQPQNVPQQQNSTKKNQSEVSNKGKKQKTVTPLTEIKVQTNVNSNTNIKINEAGKKQQQQQQLQQQQQQQQQQKKKKDNQKNNKQAKQAPSQQKTPVSSNTNLSNVNSSNSNSNSGSSTHGQAKDMTRINIENLKLPPGITITKVDVPVKPFPIKSTPLAKATSNTPPNKQATIIASPMSAGGIHGSYGGPQAGANVIVVDTGKLKQDLNPNDKGASKEPSKSSKKKKKKNAAAAAAAAKNALQNNSQSNDNSERYQNDELARIVHNPGSNMVTIRNPAFGSLPKVEPVQQQAAIIKLSDNGMVTIRSPALQHALNNGLTPPPKPDFIVKGEFLNENSKPASGQKSANISSSLADLRSRLTPDCTGITGLANIQISKVTSGQQVIPENGINLKGTSVTLTKVKNPDVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H627</accession>
    <name>A0A8J2H627_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RNA helicase</fullName>
            <ecNumber evidence="3">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">HICCMSTLAB_LOCUS2511</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:13066"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DNA2/NAM7 helicase family. SDE3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="3"/>
    <dbReference type="EMBL" id="CAJNRD030001117">
        <property type="protein sequence ID" value="CAG5077606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H627"/>
    <dbReference type="OrthoDB" id="6513042at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032574">
        <property type="term" value="F:5'-3' RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031047">
        <property type="term" value="P:regulatory ncRNA-mediated gene silencing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18038">
        <property type="entry name" value="DEXXQc_Helz-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18808">
        <property type="entry name" value="SF1_C_Upf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000326">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041679">
        <property type="entry name" value="DNA2/NAM7-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041677">
        <property type="entry name" value="DNA2/NAM7_AAA_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049080">
        <property type="entry name" value="MOV-10-like_beta-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026122">
        <property type="entry name" value="MOV-10/SDE3_DEXXQ/H-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047187">
        <property type="entry name" value="SF1_C_Upf1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45418">
        <property type="entry name" value="CANCER/TESTIS ANTIGEN 55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45418:SF1">
        <property type="entry name" value="CANCER_TESTIS ANTIGEN 55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13086">
        <property type="entry name" value="AAA_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13087">
        <property type="entry name" value="AAA_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21634">
        <property type="entry name" value="MOV-10_beta-barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 15" id="KW-0347">Helicase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0943">RNA-mediated gene silencing</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="14">
        <location>
            <begin position="234"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="13">
        <location>
            <begin position="255"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="770"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="781"/>
            <end position="796"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CAG5077606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="837" mass="96427" checksum="4154CD202D11719B" modified="2022-05-25" version="1">MDQFNQNQNDIENVIKSKSAKDCIDGLPPLSMGGAFIPAQLSEVLDNKIKPFSGMTEIHAQYYAIVSGLASFDYNKLNEQNYWYLWKLLLYIEYHQYLKDMQKYSLFNQRLERSQKRPDEFLVAVPGLLEDRPSLKEFDQIDLMQANGKNHCVGIVTHVGQDYVSVDVPLAFRNTYKQDQIFNIVFRIDDWTAKCWNYILDTVDKENITSMLFPTSQSSSYVIGDKKKIEWINKNIETNPEQQQAVLNILNKTSHTAPYILFGPPGTGKTSTLVETICQIMRKNSSTKILICTPSNAAADEIAERLLKNLGFVEDDFMYRMYSSSRSSDDVKQELKSFSNFADRKTVFVNKEVFMTKKIVITTLATCIRLHGYKLRENYFSYLFIDEAGQATEIDTLIPMVLMCGKDSTNSSKFSGQVVIAGDPKQLGPTVQSRVAEPLLGKSMLERLMGWSLYAKQNNKYNPRYVTKLVQNYRCHEAILSVPNDLFYEGELVAMGGEHTTRAVNWPMLPRNNFPVIFHAIKGKEGRKKYSPSVYNDNEIGQVIYYVKKLLHKKLGSKIVMPEDIGIVTPYKLQRSIMHKALEYHNLNNISVGTVEVFQGQEKDIIIISTVRSVIYKTEENTFHIGFLSNPKRFNVALTRAKSLLIVIGHPDILQQDYCWRAFVKYCVKNNACNGEYFTLDQSLDNLDIRQITERKLSKELMKNGRKKIVEDDEILKDQEIDFKDLPRRRRVPSGPLSFNERYSSNKIQEILSSFDNGYHRQLQVDNFDAFSDGSDASEGSVEEDEEINDPEEQFDENSRMAKEFFASYLKKLTIEEEKYEEEMKLKIKMKELEISD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H640</accession>
    <name>A0A8J2H640_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Transaldolase</fullName>
            <ecNumber evidence="3 8">2.2.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HICCMSTLAB_LOCUS2595</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the rate-limiting step of the non-oxidative phase in the pentose phosphate pathway. Catalyzes the reversible conversion of sedheptulose-7-phosphate and D-glyceraldehyde 3-phosphate into erythrose-4-phosphate and beta-D-fructose 6-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>D-sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate = D-erythrose 4-phosphate + beta-D-fructose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:17053"/>
            <dbReference type="ChEBI" id="CHEBI:16897"/>
            <dbReference type="ChEBI" id="CHEBI:57483"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="2.2.1.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 8">Carbohydrate degradation; pentose phosphate pathway; D-glyceraldehyde 3-phosphate and beta-D-fructose 6-phosphate from D-ribose 5-phosphate and D-xylulose 5-phosphate (non-oxidative stage): step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transaldolase family. Type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.2.1.2" evidence="3 8"/>
    <dbReference type="EMBL" id="CAJNRD030001117">
        <property type="protein sequence ID" value="CAG5077935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H640"/>
    <dbReference type="OrthoDB" id="2015515at2759"/>
    <dbReference type="UniPathway" id="UPA00115">
        <property type="reaction ID" value="UER00414"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004801">
        <property type="term" value="F:transaldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009052">
        <property type="term" value="P:pentose-phosphate shunt, non-oxidative branch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00957">
        <property type="entry name" value="Transaldolase_TalAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000088">
        <property type="entry name" value="Transaldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00492">
        <property type="entry name" value="Transaldolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001585">
        <property type="entry name" value="TAL/FSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004730">
        <property type="entry name" value="Transaldolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018225">
        <property type="entry name" value="Transaldolase_AS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009001">
        <property type="entry name" value="PRK12346.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00874">
        <property type="entry name" value="talAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10683">
        <property type="entry name" value="TRANSALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10683:SF18">
        <property type="entry name" value="TRANSALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00923">
        <property type="entry name" value="TAL_FSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01054">
        <property type="entry name" value="TRANSALDOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00958">
        <property type="entry name" value="TRANSALDOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0570">Pentose shunt</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0704">Schiff base</keyword>
    <keyword evidence="4 8" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAG5077935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="325" mass="36036" checksum="8B36B187E6BC9CA5" modified="2022-05-25" version="1">MSGSPAGKKQKMVSSLEQLKTFTTVVADTGDFQAMEQFKPTDATTNPSLILAAANQKKYAHLLDKAVQYGKKSGSTLEEQTEAAIDMTCVLFGQEILNIIPGRVSTEVDARLSFDKEASIEKAKKLITLYEEAGISKERILIKLASTWEGIQAAKELEEKYGIHCNLTLLFNFAQAVACAEAGVTLISPYVANTDKKSFEAKEDPGVVSVTKIYNYYKKFGYKTVVMGASFRNVGEIKELAGCDLLTISPKLLEDLEKSHEPVRKMLAPEVAKKADLKKISLSEAQFRWMLNEDQMATDKLSDGIRKFAVDMRKLEQLLQEKIQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H6I9</accession>
    <name>A0A8J2H6I9_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Neuropathy target esterase sws</fullName>
            <ecNumber evidence="4">3.1.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Swiss cheese</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">HICCMSTLAB_LOCUS2831</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="16">Phospholipase B that deacylates intracellular phosphatidylcholine (PtdCho), generating glycerophosphocholine (GroPtdCho). This deacylation occurs at both sn-2 and sn-1 positions of PtdCho. Its specific chemical modification by certain organophosphorus (OP) compounds leads to distal axonopathy. Plays a role in the signaling mechanism between neurons and glia that regulates glia wrapping during development of the adult brain. Essential for membrane lipid homeostasis and cell survival in both neurons and glia of the adult brain.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>a 1-acyl-sn-glycero-3-phosphocholine + H2O = sn-glycerol 3-phosphocholine + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15177"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16870"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="ChEBI" id="CHEBI:58168"/>
            <dbReference type="EC" id="3.1.1.5"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Interacts with Pka-C3; interaction inhibits the catalytic function of Pka-C3 and the esterase activity of sws.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NTE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="23">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.5" evidence="4"/>
    <dbReference type="EMBL" id="CAJNRD030001117">
        <property type="protein sequence ID" value="CAG5078764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H6I9"/>
    <dbReference type="OrthoDB" id="421051at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004622">
        <property type="term" value="F:phosphatidylcholine lysophospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007399">
        <property type="term" value="P:nervous system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046470">
        <property type="term" value="P:phosphatidylcholine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="CDD" id="cd07225">
        <property type="entry name" value="Pat_PNPLA6_PNPLA7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.10:FF:000010">
        <property type="entry name" value="neuropathy target esterase isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.10:FF:000122">
        <property type="entry name" value="Neuropathy target esterase sws"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.10:FF:000135">
        <property type="entry name" value="Neuropathy target esterase sws"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1090.10:FF:000022">
        <property type="entry name" value="Neuropathy target esterase sws"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1090.10">
        <property type="entry name" value="Cytosolic phospholipase A2 catalytic domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001423">
        <property type="entry name" value="LysoPLipase_patatin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050301">
        <property type="entry name" value="NTE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056556">
        <property type="entry name" value="NTE1_P-loop_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002641">
        <property type="entry name" value="PNPLA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14226:SF29">
        <property type="entry name" value="NEUROPATHY TARGET ESTERASE SWS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14226">
        <property type="entry name" value="NEUROPATHY TARGET ESTERASE/SWISS CHEESE D.MELANOGASTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24179">
        <property type="entry name" value="NTE_Ploop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01734">
        <property type="entry name" value="Patatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="cAMP-binding domain-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51635">
        <property type="entry name" value="PNPLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01237">
        <property type="entry name" value="UPF0028"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 19" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12 19" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="14 19" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0524">Neurogenesis</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="21">
        <location>
            <begin position="77"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="21">
        <location>
            <begin position="376"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="21">
        <location>
            <begin position="482"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="domain" description="PNPLA" evidence="22">
        <location>
            <begin position="816"/>
            <end position="982"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="231"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="1201"/>
            <end position="1234"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXGXXG" evidence="19">
        <location>
            <begin position="820"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXSXG" evidence="19">
        <location>
            <begin position="847"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="DGA/G" evidence="19">
        <location>
            <begin position="969"/>
            <end position="971"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="8"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
        <location>
            <begin position="244"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="19">
        <location>
            <position position="849"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="19">
        <location>
            <position position="969"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00025020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00030862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00049531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS51635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="CAG5078764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="1263" mass="141727" checksum="B754C2FF95C9C3B7" modified="2022-05-25" version="1">MLRKVKSISGQVNSSSGQGKKRRAVMRFARRLLQLKKETVPQQLKVLEPPAEYLEEDLGPGERVPPDALYILQSIRVFGHFEKPVFLKLCKHTEIMNLPAGTALFKIGDPDENVFIVQQGLVNVYITGSDGAQIPLKLVNTGESVTSLLSFTDVLTGHTSTYKTVSARAVEDSVVVKLPMSAFQEVFQDHPDAFIRVIQVIMVRLQRVTFTALHQYLGLSAELVNQGLAKKKQSPFSGSPVRSRTRENFDLTPTDKTDKTLDLLPQTPTQPVSINLKKPKHEWKVSDEAAPDMVPECDHHWSDSSHPGSRKRSAVDQPLIASVQDEAQLVQIATDAFVKELGLEDDSVLKDGKVQIREVAAGTYLMKEESNKDVALVYVLSGSLVISQRGSEGGRPGDSSDQVHMFSAHTGEIVGGLAVLTGEPSFYTIRAKHPSRIALLSKQTFFAIMREKPTIVLHVANTVVRRLSPFVRQVDFALDWLFLESGRAVYRQGDESDSTFIVLSGRLRSVITHNNGKKELVAEYGKGDLVGIVEMVTQTPRSTTVMAVRDSELAKLPEGLFNVIKLRYPIVVTRLINLLGHRILGSWQQVATTRSSIKTQHRPTATTFDARPSQVNFSTVAIVPVSEDVPLTAFTYELYHSLCAIGPCLRLTSDVVRKTLGTSIMETPNEYRLTSWLAQQEDQHRISLYQCDSTYTAWTQRCVRQADCILIVGLGDKPPTLGRTEREVERLAMRTQKELVLLHKEHGQRPSNTVEWLNMRSWVSSHHHIQCPKRMFTRRSQYRINELYSKVLMSEPNVHSDFSRLARWLTGTSVGLVLGGGGARGAAHIGMLKAILEAGIPIDMVGGVSIGSFMGALWCMEKNITTTTQKAREWSKKMTQWWRQILDLTYPMTSMFSGKDFNKTIQTTFGDTYIEDLWLPFFIITTDITASCMRTHTHGSLWRYIRSSMSLSGYMPPLCDPTDGHLLLDGGYVNNLPGPLWKYVRASMTIAGVFPPICDPLDGHLLVDGCYVNNVPADIMLRQGAHHILAIDVGSQDDTDLTNYGDSLSGWWLLWKRWNPFATPVKVPNLPDIQSRLAYVSCVRQLEEVKSSDYCEYIRPPIDKYKTLQFANFDEIKDVGYHHGKTYFEGQSKAGVLPRFNADRETAKALRAKHQSNQDSISSYTFTDLAQMVCKVSTRNRRYDLDLDSESDEFEEYEADMEEDNHEVGYASEPTAGILDQSPEDNRLRRRPGISLSLSDTEAESELEYHPKSPVALHCKFRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H6U1</accession>
    <name>A0A8J2H6U1_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Similar to X-element\ORF2: Probable RNA-directed DNA polymerase from transposon X-element (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HICCMSTLAB_LOCUS3020</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001117">
        <property type="protein sequence ID" value="CAG5079473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H6U1"/>
    <dbReference type="OrthoDB" id="7701509at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052560">
        <property type="entry name" value="RdDP_mobile_element"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36688">
        <property type="entry name" value="ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36688:SF2">
        <property type="entry name" value="ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="433"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="domain" description="Reverse transcriptase" evidence="3">
        <location>
            <begin position="323"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="129"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="135"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG5079473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="888" mass="100651" checksum="923C511C87B50C22" modified="2022-05-25" version="1">MNLVRDHDIILLTETWLKPEEPFYINNYNIIRKDRQDSNGGGLAIAVKTNISFEVLSDFLEIEDQIDTLAIKINTNQGPIIFATTNIDWKAFEDILTQKAEANSALAEPTTEAYDEFIKIIKDPLLEATKPGNKAHNNSGKQNHTQPQRDNSAVRKIRTPAPWWNDDCAAVLEERKAALQIMKRQLTVESYAKYKQAEAKAKQTFYQTKKKAWQEFTETLNGTTPISVIWKKFKAFKNRRLTSPHALPRQELSAEPKKQDFIKTYSLPATDDFPETPITLTELNSAINRSKSGSSPGLDQISHEIIKRLPESLKTRLLDYYNNFIKRSKYPLAWTEHLVYLLPKGDTGKFRPITLAPCFLKVMEKIVVDRTTWWLEHNNKIPDTQFGFRTGKSTADNLAVVVGDIYTGLAAGEFIITAFLDIKGAFDHVNPDILLQILVNTGIPTAYCLFFYYLIKQRKLYFVTNNGLTEPQLVNSGAGQGLVSAPLLFTLYTADGGKHIHSSSKIAEFADDKAIRCRNKNLQYAIDALQASLDSYSAYLEKLNLQLSPEKTKIIIFTHNDYNPRDISFTIKDVTVKPTTSAKFLGITLDQKLTFEDHYSNILTKINKVFPLIKSLCGTKWGAAPATLLNIYRALIRTKIEYGSHIMNAISSKLFSKLEKVQNKAIRTSMGLRISTPINSMMAEGGEIPLKIRLKDLSDRYTLKSLSTTNNPVINTLRTLDECLTQNKSKQYIYKRFPAISSYHDTIPQHDIIYQSIAHPRYTHTYSIFQHPLNIDLTNVATLTNMSQRDTIETFEKMTNEKYKNLTQVYTDASKSPDEPHVGVAIYNATLNTQLTFKINQQASATTAEALAILKAVEVALEMQEGTIRAFEFPSIKKKKHIIIQMVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H6V2</accession>
    <name>A0A8J2H6V2_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS3035</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001117">
        <property type="protein sequence ID" value="CAG5079530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H6V2"/>
    <dbReference type="OrthoDB" id="7675048at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="204"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5079530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="274" mass="31889" checksum="F7405764127116BE" modified="2022-05-25" version="1">MKVNNLLNISKNLFFNVTNHTNCDSEGIYGDILLKPSKVSVPTDLDQLNDSDRYKNYENLPIHEETLNTNQNFSKISENNTNELENKPIDSSTQLYIITKSPLFDFTEEKSKSNKKKQSYSYYLLNYIPINQLKRVHTILIENLGKTHKEKLQFLQSFKNDLSKTIRSMIPEVINRNADSRARKKRGSSWDEHDSHIGFPSLEGALLAISFLTFAIYLIRLIMMLMKNFGNNTTGSTILINRNKRFITELTEEAARIHGYLHEFDSRFQSRRNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H7I1</accession>
    <name>A0A8J2H7I1_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similar to nudt21: Cleavage and polyadenylation specificity factor subunit 5 (Danio rerio)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS3477</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5082176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H7I1"/>
    <dbReference type="OrthoDB" id="277288at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005849">
        <property type="term" value="C:mRNA cleavage factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031124">
        <property type="term" value="P:mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016706">
        <property type="entry name" value="Cleav_polyA_spec_factor_su5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13047">
        <property type="entry name" value="PRE-MRNA CLEAVAGE FACTOR IM, 25KD SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13869">
        <property type="entry name" value="NUDIX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5082176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="173" mass="19907" checksum="23007D23F4493250" modified="2022-05-25" version="1">MAMATTQVKGSGWPRRSSNSSFEGKPVQNQSVTILRTVNLYPLTNYTFGTKEPLFEKDPSVPARFQRMRDEFDKIGMRRSVEGVLLVHEHGLPHTLGRQDGVKQEWVIEDTIGNWWRPNFEPPQYPYVPPHITKPKEHKRLFLVQLQEKGIINYQVSFGLAYLSINPAAICKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H7N6</accession>
    <name>A0A8J2H7N6_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS3617</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5082648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H7N6"/>
    <dbReference type="OrthoDB" id="7700380at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5082648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="132" mass="15468" checksum="564CF035C60B9174" modified="2022-05-25" version="1">MNNMYTSTTMYTYQVKSSIVKQSQEYPESKHLQTIKISYIPVHSRYENASVKLKWKNERSKLFEVLDSKILKISEDKDLPDNISVGENTGRNPGCNNKSVFRNCFSATDHFSICNRYLYRILQNSVMYLISY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H7S5</accession>
    <name>A0A8J2H7S5_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein uL6</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">60S ribosomal protein L9</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HICCMSTLAB_LOCUS3328</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5081588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H7S5"/>
    <dbReference type="OrthoDB" id="10252633at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.930.12:FF:000003">
        <property type="entry name" value="60S ribosomal protein L9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.930.12:FF:000004">
        <property type="entry name" value="60S ribosomal protein L9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.930.12">
        <property type="entry name" value="Ribosomal protein L6, alpha-beta domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000702">
        <property type="entry name" value="Ribosomal_uL6-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036789">
        <property type="entry name" value="Ribosomal_uL6-like_a/b-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020040">
        <property type="entry name" value="Ribosomal_uL6_a/b-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002359">
        <property type="entry name" value="Ribosomal_uL6_CS2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11655:SF16">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11655">
        <property type="entry name" value="60S/50S RIBOSOMAL PROTEIN L6/L9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00347">
        <property type="entry name" value="Ribosomal_L6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002162">
        <property type="entry name" value="Ribosomal_L6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56053">
        <property type="entry name" value="Ribosomal protein L6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00700">
        <property type="entry name" value="RIBOSOMAL_L6_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL6 alpha-beta" evidence="6">
        <location>
            <begin position="12"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="Large ribosomal subunit protein uL6 alpha-beta" evidence="6">
        <location>
            <begin position="97"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAG5081588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="190" mass="21520" checksum="8C077688D0CEB767" modified="2022-05-25" version="1">MKQIVTNQMVKIPDGLTASVKSRMVTVKGPRGTLKRSFKHLALDIRMINPRTLKVEKWFGKKKELAAVRTVCSHIENMLKGVTKGYIYKMRAVYAHFPINCVTTENNSVVEIRNFLGEKFIRRVKMAPGVTVSNSTKQKDELIVEGNSLEDVSRSAALIQQSTTVKNKDIRMFLDGLYVSEKTTVQEDNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H7T0</accession>
    <name>A0A8J2H7T0_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DNA-(apurinic or apyrimidinic site) endonuclease</fullName>
            <ecNumber evidence="9">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HICCMSTLAB_LOCUS3484</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Exonucleolytic cleavage in the 3'- to 5'-direction to yield nucleoside 5'-phosphates.</text>
            <dbReference type="EC" id="3.1.11.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7 9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="7 9">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="7 9">Probably binds two magnesium or manganese ions per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the DNA repair enzymes AP/ExoA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="9"/>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5082197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H7T0"/>
    <dbReference type="OrthoDB" id="17335at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003906">
        <property type="term" value="F:DNA-(apurinic or apyrimidinic site) endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008311">
        <property type="term" value="F:double-stranded DNA 3'-5' DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09087">
        <property type="entry name" value="Ape1-like_AP-endo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004808">
        <property type="entry name" value="AP_endonuc_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020847">
        <property type="entry name" value="AP_endonuclease_F1_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020848">
        <property type="entry name" value="AP_endonuclease_F1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00195">
        <property type="entry name" value="exoDNase_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00633">
        <property type="entry name" value="xth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22748">
        <property type="entry name" value="AP ENDONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22748:SF6">
        <property type="entry name" value="DNA-(APURINIC OR APYRIMIDINIC SITE) ENDONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00726">
        <property type="entry name" value="AP_NUCLEASE_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00728">
        <property type="entry name" value="AP_NUCLEASE_F1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51435">
        <property type="entry name" value="AP_NUCLEASE_F1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="12" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 7 9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0464">Manganese</keyword>
    <keyword evidence="4 7 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0540">Nuclease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="11">
        <location>
            <begin position="244"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="88"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="127"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="139"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="171"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="247"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="275"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="387"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="389"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="8">
        <location>
            <position position="389"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="8">
        <location>
            <position position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR604808-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR604808-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU362131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAG5082197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="748" mass="85611" checksum="3F46B97329382216" modified="2022-05-25" version="1">MSLKTKEEDPAEEKVEVQPKKRAAKKDAKKEEENGGEVEKKSKKGKKKNDEDSEADNENVDQGVKSGKQVEPAEEVEEKQSKTRGRKKKEEADEKEEKEVKSKKGKKDEKPKEDDKKKPPVKRGKKKAEDKEAEAVDEAKEDEDVEMKEEDPETKAVNGDDKKKSKAKPPKKTEDEPKKVEDEDTFKGRSTRTNKKKNETADEEEPAAKKAKTPANKTDTNLDEINFDCDKENAEGKKSNFKVCSWNVSGIRALLKKNGFEYIIKEDADIIALQETKCDLSKLPDDINIPGYKHKFLESTGQSGYSGIAVYSKEEFVSVTEGINDPDLDKEGRMLTIEYPNFYFVNVYVPNAGDKLKTMDKRMKWNTLFEERIKELDSKKPVIICGDLNVAHQEIDLKNPKANIKHAGFTPEERQGMTSLLEAGFVDVFRHFYPDKTDAYTFWSNLGKSREKNTGWRLDYYLVSDRIKDKVCDTVIRDKFEKISVRMISEMEGEDLTDSEQVRATLETYKKLANDFSNHDTILKDKTVLSYLAYVLESPDVEVVETALDILEVLTKNVENYVHLTSTFGIREALESVINKYCIDDPHIAKYGQKVKDDIERMKPPIYNLRSRCRRVIEPKKLKTHVIVLHVSGLLPETRTDLEATLVRVEGLISLVVDVEHQRVTMRTLANVSAKCIAEAIRDNTKNMEARLVTRNKFNQEFLVKLEEEEEEEETQKDGIVSLFSGLKQSASTIYKSTTEFLHSSFYW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H7V9</accession>
    <name>A0A8J2H7V9_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS3773</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5083230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H7V9"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5083230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="119" mass="12821" checksum="E207AAF485681EA8" modified="2022-05-25" version="1">MWAVIRDPEAPKGCPRAIAPPLTFNLLISRPKSLTQARVCAPKASLISTSSRSLRVFLDSFKRCLIAGAGPIPMILGSTPTVVYPYKRARVCGRGCSSTDTSICFFFMVIETGAISALK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H8B6</accession>
    <name>A0A8J2H8B6_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Retrovirus-related Pol polyprotein from transposon TNT 1-94-like beta-barrel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS4074</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5084314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H8B6"/>
    <dbReference type="OrthoDB" id="413361at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054722">
        <property type="entry name" value="PolX-like_BBD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22936">
        <property type="entry name" value="Pol_BBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Retrovirus-related Pol polyprotein from transposon TNT 1-94-like beta-barrel" evidence="1">
        <location>
            <begin position="61"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF22936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5084314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="132" mass="14365" checksum="0F09411B55E4F3C2" modified="2022-05-25" version="1" fragment="single">MVSTRSRVTSVVKRGIRQMCVLPRSLKKPSANNVDESYAVSHTVINGVCHNAKISTANRAWLLDSGCTAHLCGDQECFKSMSESSNIKLILASQASTQVKGSECAEAAVQYGCSELLKWHARLGHLNVKDLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H8P3</accession>
    <name>A0A8J2H8P3_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Similar to Ipo7: Importin-7 (Mus musculus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HICCMSTLAB_LOCUS3188</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the importin beta family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5081080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H8P3"/>
    <dbReference type="OrthoDB" id="760868at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000813">
        <property type="entry name" value="D-Importin 7/RanBP7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001494">
        <property type="entry name" value="Importin-beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058669">
        <property type="entry name" value="TPR_IPO7/11-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013713">
        <property type="entry name" value="XPO2_central"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10997:SF18">
        <property type="entry name" value="D-IMPORTIN 7_RANBP7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10997">
        <property type="entry name" value="IMPORTIN-7, 8, 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08506">
        <property type="entry name" value="Cse1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03810">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25758">
        <property type="entry name" value="TPR_IPO11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00913">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50166">
        <property type="entry name" value="IMPORTIN_B_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Importin N-terminal" evidence="9">
        <location>
            <begin position="22"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="821"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="870"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="945"/>
            <end position="968"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="823"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="951"/>
            <end position="960"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAG5081080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="968" mass="110258" checksum="A93C4EE0F71CF7CC" modified="2022-05-25" version="1">MDPRRLTEYLRATIDPAQQKDAEDQLNQIHKIIGFAPTLLQVIMSGEVEMPVRQAGVIYLKNLIVSNWADREPENGVAPFNIHEQDRAMIRDSIVDAVVHAPELIRIQLAMCISNIVKHDFPARWTQILIIRLLPDPSEQSVLLQKQILKIFFALTQYSLPLDLISKESFSQWMDVIRQIADRPVPPETNNPDIDDDERADLPWWKCKKWALHILHRVFERYGSPGNITKEYKEFSEWYLRTFSAGILEVLLKILDQYRRSIYVSPRVIQQSINYINQGVSHAYSWKFLKPHMFEIIRDVLFPILSYSASDEELFTNDPYEYIRLKFDIFEDFVSPVTAAQTLLHSACKKRKEMLQKTVQFCIEVLTNPTADPRQKDGALHMIGSLADVLLKKNLYKEQMDKMLMSYVLPEFSSPHGHMRARACWVLHYFSKIKFKDEHILINATKIIVHLLLNDADLPVKVEAAICLQSLLSSQEKSQKCVEPMVKNITLELLNIIRETENDDLTSVMQKIVYTYTKQLTPIAVEICQHLATTFSQVLETDEGSDEKAIMAMGLLNTIATLLSVMEDQPEIMAQLQPTVLRVIAHIFGQSIIEFYEEALSLVYDLTGKFISEDMWKVLELMYQLFEKDGFDYFTDMMPALHNYITVDTAAFLSNENHILAMFNMCKAILTGDAGEDPECHAAKLLECKGRIDHCITPLVQLVLERLTREVKTSELRTMCLQVVIAALYYNPALCLQAMDGLQGQLGQSTEPIASHFIKQWIHDTDCFLGLHDRKLCVFGLCTLISMGPNRPQAVNECAQQIIPSLILLFDGLKRAYAAKVAEDDDEDGDTEDSEGDEEVLSSDEDEIDDASQEYLEKLQDKVTRSAGQHGFNINASIQDGDRSDVDDDDSEFEANEETALETDQAWYVALTGHLTVEQQKALQEVILLADQRKAALESKRIEQSGGYAFHSQTVPSSFNFGGKPPGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H8V9</accession>
    <name>A0A8J2H8V9_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ZP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HICCMSTLAB_LOCUS3496</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5082232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H8V9"/>
    <dbReference type="OrthoDB" id="8171348at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057475">
        <property type="entry name" value="CUT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001507">
        <property type="entry name" value="ZP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46560">
        <property type="entry name" value="CYPHER, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46560:SF9">
        <property type="entry name" value="ZP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25301">
        <property type="entry name" value="CUT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00241">
        <property type="entry name" value="ZP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51034">
        <property type="entry name" value="ZP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="284"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="domain" description="ZP" evidence="3">
        <location>
            <begin position="1"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="379"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="389"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG5082232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="422" mass="46886" checksum="DB48B2D40E7C3B7A" modified="2022-05-25" version="1">MKKINMSKYLYKASGFTMWFIVLVIAALHQVTGQLLDNEFQPTVTATCKDGYMTIRLNLNDSFVGALHARDYRTSQCMVAGNGSKQATLGINLLAVHGAPDYCGVIINNSTEERSLPIAVRIHKTLELADDKFYVITCGKAGFKNAKNETSLVSLRLLDSGRRVQEAIYGHNYTLRMYGIRVKSCFAFNKRNSSVQLIDDRGCPVKNHVITKFIYDTNTGIADATLYSMFRFPESPQVHFQCDIAVCRGEEGILLAGTSVFVLNPGETPVVQTLYDDGAVHPQWLLWLAVAFGILFLIMLIINILLCSAMTCSCARTEIIEKEPSIIEDYDPYRSWPGSQYGSRYSLNGKPGGYPSGGSTMNSTRSISTNSDHYAIVQSRPGSRYSGPGHKHHHHHHHRGPPSNIGSHYSLAPLRSEILGYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H8W7</accession>
    <name>A0A8J2H8W7_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS3345</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5081654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H8W7"/>
    <dbReference type="OrthoDB" id="10255512at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="157"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="44"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5081654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="205" mass="24150" checksum="CD2EBCA951D3F6F5" modified="2022-05-25" version="1">MNRDKTVYVLIFLWPRKTEKINNPENKVITPEQLNSLLEEDDTLIELQEGIASGRQKLEDLTNDIRVKEEQLRTLKSKIVEKNYELKEKNDECTRLANLISEKKQTGKPVDVQMEEKMEECTRLDGQILEKTKINDDLDFQIKTKAEKRNLVDREITVKNQKNKDRDSEMNEKSQEIGRLGKLITEKIQTTQIKDIQIKEKDDDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H9K5</accession>
    <name>A0A8J2H9K5_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Similar to SULT1C4: Sulfotransferase 1C4 (Homo sapiens)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HICCMSTLAB_LOCUS4886</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sulfotransferase 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5088537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H9K5"/>
    <dbReference type="OrthoDB" id="205623at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008146">
        <property type="term" value="F:sulfotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000863">
        <property type="entry name" value="Sulfotransferase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11783">
        <property type="entry name" value="SULFOTRANSFERASE SULT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00685">
        <property type="entry name" value="Sulfotransfer_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Sulfotransferase" evidence="3">
        <location>
            <begin position="58"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG5088537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="303" mass="35872" checksum="60B93D1A43F9CE85" modified="2022-05-25" version="1">MSSLPKYKLLDKEKTKEMLEKFTGERTGWVQVGEKKWFFPHRYIEQQEGFYNFKARLDDTWVITYPRSGTTWTQELVWLLKKQELCKKITIPGYEVLNGMPSPRFIKSHFPLSLLPGILDVGCKIIYVARNPKDVAVSWYHLNQAIKTQGYNGNFEEFWNYFQDDLTPWSPYWEHLKEAWAQRHHPNLFFIFYEEMQQNFFQTAYKVAEFLGKSYSEKEMCKLSDYLNIKNFRNNPMVNSSELRDCHIIADGGFVRNGQSGVWSNTFSPKLEAKADAWIKKNLQDTDLVFPYFNNNNISQLIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HA58</accession>
    <name>A0A8J2HA58_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Spaetzle domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS3812</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5083345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HA58"/>
    <dbReference type="OrthoDB" id="6381819at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.90.10">
        <property type="entry name" value="Cystine-knot cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029034">
        <property type="entry name" value="Cystine-knot_cytokine"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="207"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="207"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5083345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="234" mass="27196" checksum="9174B64D6675F6FF" modified="2022-05-25" version="1">MYIKESHAGTVVWLTAVLSRFVDASKLRNNLTRTIRDTSFHGASLWSQEEQVTKRIGLTYREIQSILRREGGEEGLPVDCCPTVEEITEPTGGKNRNESYVELYRGLEQIQRFYEYSCRQDVLDKPCRFVDRKLSGQSRCVQKFSYSYAIVKNPAAEISIMENENMEHHHRHRHEAHYFSSYGSSWTVDHIRVRSGCSCEIIPKPKKKRPLSLKSKKLKHKPKKKDDFITNSDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HA62</accession>
    <name>A0A8J2HA62_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Mitochondrial (Macaca fascicularis)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HICCMSTLAB_LOCUS5465</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MnmG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5090032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HA62"/>
    <dbReference type="OrthoDB" id="3329at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070899">
        <property type="term" value="P:mitochondrial tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.570:FF:000001">
        <property type="entry name" value="tRNA uridine 5-carboxymethylaminomethyl modification enzyme MnmG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000002">
        <property type="entry name" value="tRNA uridine 5-carboxymethylaminomethyl modification enzyme MnmG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.570">
        <property type="entry name" value="GidA associated domain, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053921">
        <property type="entry name" value="MKRN2OS-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053922">
        <property type="entry name" value="MKRN2OS-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002218">
        <property type="entry name" value="MnmG-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020595">
        <property type="entry name" value="MnmG-rel_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026904">
        <property type="entry name" value="MnmG_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047001">
        <property type="entry name" value="MnmG_C_subdom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044920">
        <property type="entry name" value="MnmG_C_subdom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040131">
        <property type="entry name" value="MnmG_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11806">
        <property type="entry name" value="GLUCOSE INHIBITED DIVISION PROTEIN A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11806:SF0">
        <property type="entry name" value="PROTEIN MTO1 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16044">
        <property type="entry name" value="DUF4796_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22795">
        <property type="entry name" value="DUF4796_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12831">
        <property type="entry name" value="FAD_oxidored"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01134">
        <property type="entry name" value="GIDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13932">
        <property type="entry name" value="SAM_GIDA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01228">
        <property type="entry name" value="GIDA_assoc_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01280">
        <property type="entry name" value="GIDA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01281">
        <property type="entry name" value="GIDA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="tRNA uridine 5-carboxymethylaminomethyl modification enzyme C-terminal subdomain" evidence="5">
        <location>
            <begin position="678"/>
            <end position="751"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAG5090032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="764" mass="86345" checksum="F5C2F08187DC4A8B" modified="2022-05-25" version="1">MDYDILCFKHCNSQSIFCKAIPEKCPICQVELKNLSTEPFVLPYCCTKATNNPASIVLKPSVGTFCNDYTITKDMHIGVVDSQCQLYEYDHRGIIHNNFNDWTDCIVINNLVPESWYSHWDKTLSDIVINPAWSSSNYDSEKFNCYNFIIEFLKLLNYENLKFIDKEHVFNEFFLPKLRYTLKIRKEENKLMMSLRKIIRSPLFITKIERIKIGHRDIQTASSSHENKDDGNKYDVIVIGGGHAGTEACAAAARMGAKTLLVTHKKSTIGEMSCNPSFGGIGKGNLVREVDALDGVCSRICDVSGVHYKILNKQDGTKIFSETVVITTGTFLKGQINIGLEKRPAGRIGDEPSIGLANTLEDLGFRMSRLKTGTPPRLKKSTIDFSKCGIQVPDEIPEPFSFMNERVLINPSDQLPCYITYTNERVAQIIRDNMHCNSHVTEEVTGPRYCPSIESKVLKFKTSGHQIWLEPEGLTSDIIYPGGLSCTLPADKQQELVNCIPGLEKAEIVRPGYGVEYDFIDPRELTYELETRRIRGLFLAGQINGTTGYEEAAAQGIIAGANAAARVLNKPALIVDRTEGYIGVLIDDLTSRGTTEPYRMFTSRAEFRVSLRPDNADLRLTGKGFRTGCVLTERMEKTSKLKERLQESMHLLGSISKTNKEWSELFGIKRVKDNKIEVSYDYCIQEQLIEVEEVRKHEKMLIPLDFNYEKYVKINLSTEDREKLTAMQPQTVAAATRIPGVTPAATLRIVKHLQQIKRNVYNRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HA83</accession>
    <name>A0A8J2HA83_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Similar to ift20: Intraflagellar transport protein 20 homolog (Danio rerio)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HICCMSTLAB_LOCUS5340</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5089700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HA83"/>
    <dbReference type="OrthoDB" id="10254896at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097546">
        <property type="term" value="C:ciliary base"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030990">
        <property type="term" value="C:intraciliary transport particle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097730">
        <property type="term" value="C:non-motile cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061512">
        <property type="term" value="P:protein localization to cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028172">
        <property type="entry name" value="FT20"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31978">
        <property type="entry name" value="INTRAFLAGELLAR TRANSPORT PROTEIN 20 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31978:SF1">
        <property type="entry name" value="INTRAFLAGELLAR TRANSPORT PROTEIN 20 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14931">
        <property type="entry name" value="IFT20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0966">Cell projection</keyword>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG5089700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="130" mass="15321" checksum="8095E1770D21A736" modified="2022-05-25" version="1">MAESLAKYGLFIDDLCKIRILEPEITTQSDKLKNECHDFVNKITEFKKNSEHFINLLDKLATEVEKEKMRTIGARNLLSSVEKQREVQKQKIQAMIIEKTMELERLRVQYDSVKKIELEQLETIEHLTIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HAX5</accession>
    <name>A0A8J2HAX5_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Similar to ZNF677: Zinc finger protein 677 (Homo sapiens)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HICCMSTLAB_LOCUS5794</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="1">May be involved in transcriptional regulation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5090912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HAX5"/>
    <dbReference type="OrthoDB" id="6077919at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000097">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000774">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24394:SF29">
        <property type="entry name" value="MYONEURIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24394">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="167"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="195"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="223"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="252"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="287"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="341"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAG5090912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="371" mass="43862" checksum="49F53C6DF4FD233B" modified="2022-05-25" version="1">MNINNCLSDQLIVKIEENIDEDFKVRKENHREFNQENLIDIEEIKVETNENLDDEFTSDMTEIGDIPIVKAEILFPTDEEVYKRTPVENYCTTILDDDDPLSVTETSFKYGENTEHQQSSRETSQQGFSFVNIEDIKRDLRTNFRDETEPSDRNNYTIIQNGLLKSYCCNLCPLKCRYKSHIDRHMMQHTGERPYACTMCPAKFTHRGNLNGHMRIHSGEKPFRCDICSKQFSEKSNIKRHIRIHMRVPKPYHCEICSKHFREVKYLKQHMQNIHVPKVDPPKPRVYKCLTCEAIFRQTSALKKHLLVHSKDQPFACDVCSIKFEYEDERDEHMVTHKLKFACEICPSKFVHRGNMVNHMRVYHPDVKLEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HBE4</accession>
    <name>A0A8J2HBE4_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">CYP307B1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HICCMSTLAB_LOCUS5846</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5092005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HBE4"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24303:SF27">
        <property type="entry name" value="CYTOCHROME P450 307B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24303">
        <property type="entry name" value="HEME-BINDING MONOOXYGENASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0349">Heme</keyword>
    <keyword evidence="5 7 8" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="484"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="7">
        <location>
            <position position="479"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAG5092005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="531" mass="61062" checksum="37E7B7BCB8BFFB37" modified="2022-05-25" version="1">MFSATTYLILIVVFALIALIIKDRKANSKKQKRLSRVVVDRGEKLNNNKIENLMEAPGPRPLPIIGSLHILGKHDFPYKSFSELATYYNSQVIKITLGRLPCVIINGLDNIKEVLFTKNYDFDSRPNFVRYNRLFGGDKGNSFAFSDWTELQKSRREMLRNHTFPRAFTYRYHELNVMIASEVENLLAHLDRPVDPMKVAVKPLVLNTCANIFTGYLCGQTFDWSDNCFRQMVKNFDMIFWEVNEGYAADFIPMLLPFHRNNIKKIVQATHDIRKFVVQHIVADRKQNWIPKNTDEYSESLSGGVVDQEQGCYLDNLIEHIQTNASPEMTWDNALYALEDIIGGHAAIGNFLVKIFGYLVTHQHIQKQAQKEIDSLNINDNTVGLEYKKSLPYIEGIILEAIRLIASPIVPHVANKDSSVAGYRIEKDTFIFLNNYQLNMSNELWKNPEAFDPTRFITSENKILKPDFFLPFGGGRRSCMGYKLVLYVSFSVLASLLKNFTILPSENQVYKVPIGKLALPEVTFNFRFERR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HD24</accession>
    <name>A0A8J2HD24_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS5858</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5092017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HD24"/>
    <dbReference type="OrthoDB" id="10069709at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="295"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="383"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="304"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="383"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="420"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5092017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="495" mass="54860" checksum="0C92ED4B7028FF73" modified="2022-05-25" version="1">MSEDKEIANASPFVSPRNTPVPRSRSNIANVYRSSRNNLKPFSRSNSCNATYLSKNNSDAIDTTFRVPTSTNETNKFLPSTLVAGESRTADKIFGSNKAAQVQVDTSNIGSITLGPDDNSKTLSCTSLLSDVNPQKQLLINYPSQENLLEIKNLNSKPTSANKPTTTTTTVISKPADQEISELLNSVKQYNYSNNENYCRSQSVPLHRMFNPTLMSPISNQFYSNTNSFNQSTSSSLVHTPVPSEFDDFVSITGQSDSYLLDQVDANFINDDQQFLIEDKTISSENINKIFDLLDDDDDDNNDKGLNNILNQQNNDEEDDDSGLIVLDSLPSDSINLQDTMLDPSTVDSFQKIIIQQQHHRHHQLQSRSYPNTPLPNSITPTAYHQSFTEDSNGPRSYPPTPISSSHIGSQDIYHETNEPMLSSPTLNSLNLHSTEHGNNDPTDSVCRNVSDLLETNFLTDGDPDDGLDPLTNFDGLQDVDSLAPLFNEVSDTNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HD43</accession>
    <name>A0A8J2HD43_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Histone H2B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HICCMSTLAB_LOCUS6342</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the histone H2B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5092731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HD43"/>
    <dbReference type="OrthoDB" id="1166527at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22910">
        <property type="entry name" value="HFD_H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000016">
        <property type="entry name" value="Histone H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000558">
        <property type="entry name" value="Histone_H2B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23428">
        <property type="entry name" value="HISTONE H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00621">
        <property type="entry name" value="HISTONEH2B"/>
    </dbReference>
    <dbReference type="SMART" id="SM00427">
        <property type="entry name" value="H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0158">Chromosome</keyword>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="12">
        <location>
            <begin position="17"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00017644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAG5092731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="135" mass="15220" checksum="5F6F838EE0A77408" modified="2022-05-25" version="1">MPPKTSGKAVKKSGKAQKNITKSDKKGRKKKRKESYAIYIYKVLKQVHPDTGVSSKAMSIMNSFVNDIFERIAAEASRLAHYNKRSTITSREIQTAVRLLLPGELAKHAIHHRLQTIKEKISNALEELVLFGYIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HDG6</accession>
    <name>A0A8J2HDG6_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS7223</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5093897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HDG6"/>
    <dbReference type="OrthoDB" id="10064600at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="159"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="225"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="89"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="176"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="188"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="228"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5093897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="678" mass="73472" checksum="EF9D72B4DE79D9FF" modified="2022-05-25" version="1">MNLNESSNKEAGEVEIELEESNGTDNVMSDEKNCKAKIQNGILPNGTSSKMETDNETIPYKYTSTNPPLSINICMNGCQSVAMTTENLPSPSLVSGSGSNDGTPEDPDMINNVDYNSGINKCPPKVSCNLNNELGATWSSSLNNIASIGSTSQGTCCVLRPNINGSRETAGPSGLSRREQNDRRDSSSENEGDDFSDDEDYCIYTYKGNDEAEVDERHRNGLAENQEAAGQQLSGRSSPEMDFLEMDFDPGPSCEQDTGDSDLASINEDIQNIALDNAEADSVFLNDLSGGKVQRPESLPQAQNEQNVSVELEIQDSVSLDGPSTSGLNHNPVAQCLPSTSSGIRKVGASLYNHGGIPTRESHGYHNTSGDLISPGDNRDADSELWADAAAIPLPENSTVNGLKVNLSSTLWHRMMAKKLMLHKQTAFNQSGESNLENDLCNDKLDDLQPVERVMLWSEQEAAAKQVTQIGTSACGATSAINALLALDVPFSPEVLVKSVATRLREPGTPLPRYLLSRSRAGATHKDVIRGISLASSGAVITKFFAFYPERAISLSHWLHYWISRGAVPIATLNLQNCSKESKIPDAWHHQMIFGVSQAGIYFTNPLECLPEQLVWHQLVSPSVLLVRRDDRPQPTTGTFSATHIRIPASYQSGITLVMRSDAAAAEELLQAEELPLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HDM4</accession>
    <name>A0A8J2HDM4_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS5423</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5089905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HDM4"/>
    <dbReference type="OrthoDB" id="7791091at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035240264" evidence="1">
        <location>
            <begin position="26"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5089905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="84" mass="9566" checksum="B4C9CA63B0322EB2" modified="2022-05-25" version="1">MFAKRFISIIIVFCLLYDHVSLVFASKWDNNITKRRLSNSIVEESKDTLNEIDETLRSIIVVPPGSKCPPGYRPDGKGKCRKPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HE05</accession>
    <name>A0A8J2HE05_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Tyrosine--tRNA ligase</fullName>
            <ecNumber evidence="15">6.1.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Tyrosyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">HICCMSTLAB_LOCUS5919</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>tRNA(Tyr) + L-tyrosine + ATP = L-tyrosyl-tRNA(Tyr) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10220"/>
            <dbReference type="Rhea" id="RHEA-COMP:9706"/>
            <dbReference type="Rhea" id="RHEA-COMP:9707"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58315"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78536"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:10221"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.1" evidence="15"/>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5092106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HE05"/>
    <dbReference type="OrthoDB" id="197206at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004831">
        <property type="term" value="F:tyrosine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006437">
        <property type="term" value="P:tyrosyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02799">
        <property type="entry name" value="tRNA_bind_EMAP-II_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000040">
        <property type="entry name" value="Tyrosine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000047">
        <property type="entry name" value="tyrosine--tRNA ligase, cytoplasmic isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.240.10">
        <property type="entry name" value="Tyrosyl-Transfer RNA Synthetase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002305">
        <property type="entry name" value="aa-tRNA-synth_Ic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002547">
        <property type="entry name" value="tRNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002307">
        <property type="entry name" value="Tyr-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051270">
        <property type="entry name" value="Tyrosine-tRNA_ligase_regulator"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006330">
        <property type="entry name" value="PRK08560.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00234">
        <property type="entry name" value="tyrS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11586">
        <property type="entry name" value="TRNA-AMINOACYLATION COFACTOR ARC1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11586:SF43">
        <property type="entry name" value="TYROSINE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00579">
        <property type="entry name" value="tRNA-synt_1b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01588">
        <property type="entry name" value="tRNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01040">
        <property type="entry name" value="TRNASYNTHTYR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50886">
        <property type="entry name" value="TRBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 15" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="8 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 15" id="KW-0436">Ligase</keyword>
    <keyword evidence="7 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10 15" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 14" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5 14" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="TRNA-binding" evidence="17">
        <location>
            <begin position="329"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="299"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="310"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU361234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="CAG5092106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="494" mass="54417" checksum="4ACDF5E8B2F76AE0" modified="2022-05-25" version="1">MTELTAEEKFQLITRNLAEWLGEDKLKTILQERDLKVYWGTATTGKPHIGYFTPLSKIADFLKAGVEVTILFADLHAYLDNMKSCWDLLALRVQYYEALIKATLKSIGVPLDKLKFVKGTDYQLSKEYTLDVYKLTASVTEHDAKKAGAEVVKQSADPLLSGLLYPGLQALDEQYLGVDAQFGGVDQRKIFTFAEKYLPKLGYEKRIHLMNPMIPGLAGTKMSSSEEDSKIDLLDNAAAVKKKLKKAFCEPGNIVDNGILSFSKHEIIHPGDLKAAAEVYINKLLDPIRKAFETDPNLKTLSSKAYPQPGKEKKQVEKKNPANQPAEIEPSRLDIRVGKIVEVSKHPDADSLYVEKIDVGEASGPRTIVSGLVNFVPIEEMQNRMVVILANLKPANLRGVASHGMVLCASVDGEERKVEPLRPPADAAPGDRVIVEGYEGTPDEVLNPKKKVWEKLAVDLVVNANGEASWSGNLLVTASKGKLTADSLKNVPIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HFX3</accession>
    <name>A0A8J2HFX3_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HICCMSTLAB_LOCUS9168</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="1 11">Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Mitochondrion inner membrane</location>
            <topology evidence="11">Peripheral membrane protein</topology>
            <orientation evidence="11">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the complex I NDUFS4 subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5099655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HFX3"/>
    <dbReference type="OrthoDB" id="3089at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022900">
        <property type="term" value="P:electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.190:FF:000001">
        <property type="entry name" value="NADH-ubiquinone oxidoreductase 21 kDa subunit mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.190">
        <property type="entry name" value="atu1810 like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006885">
        <property type="entry name" value="NADH_UbQ_FeS_4_mit-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038532">
        <property type="entry name" value="NDUFS4-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12219:SF8">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] IRON-SULFUR PROTEIN 4, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12219">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04800">
        <property type="entry name" value="NDUS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0249">Electron transport</keyword>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 11" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="7 11" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4 11" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU367010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAG5099655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="203" mass="23227" checksum="41C340602392C00B" modified="2022-05-25" version="1">MATSVILRYGLHIERKMNSVALLKNCITKLAGCECTRALSLSSVKLADEVKQPAHIPHDTHNLMTSPEAEEVRMANRRQLITIDEPDDVAVLSGVPEEHIKTRTVRIYMPAKNAMQSGTNNINYWQIDFDTRERWENTLMGWSSTGDPMSNLKVDFASVEEAIDHCKKMKWDYFVQKPNVDDPKPRSYGANFSWDKRTRVTTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HG31</accession>
    <name>A0A8J2HG31_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">protein-serine/threonine phosphatase</fullName>
            <ecNumber evidence="1">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HICCMSTLAB_LOCUS7491</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="1"/>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5095002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HG31"/>
    <dbReference type="OrthoDB" id="277011at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008420">
        <property type="term" value="F:RNA polymerase II CTD heptapeptide repeat phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07521">
        <property type="entry name" value="HAD_FCP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000013">
        <property type="entry name" value="Carboxy-terminal domain RNA polymerase II polypeptide A small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011948">
        <property type="entry name" value="Dullard_phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004274">
        <property type="entry name" value="FCP1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040078">
        <property type="entry name" value="RNA_Pol_CTD_Phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050365">
        <property type="entry name" value="TIM50"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02251">
        <property type="entry name" value="HIF-SF_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12210">
        <property type="entry name" value="DULLARD PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03031">
        <property type="entry name" value="NIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01124">
        <property type="entry name" value="C0.1:_RNA_Pol_CTD_Phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00577">
        <property type="entry name" value="CPDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50969">
        <property type="entry name" value="FCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FCP1 homology" evidence="7">
        <location>
            <begin position="99"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="278"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="11"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="49"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="283"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="active site" description="4-aspartylphosphate intermediate" evidence="4">
        <location>
            <position position="109"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="4">
        <location>
            <position position="111"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="5">
        <location>
            <position position="165"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="5">
        <location>
            <position position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR640078-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR640078-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG5095002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="297" mass="33022" checksum="D4D0842B46B014B3" modified="2022-05-25" version="1">MDASSIITQVSRDDELGHFNNEKAQLPRENEATSNNRPPGGKKPRGRGLLRSLLCCLGRGRGSGSSKSSKASSLQSEGRGTPPPGTRSPRYLLPPIRHQDMHKKCMVIDLDETLVHSSFKPINNADFVVPVEIDGTVHQVYVLKRPYVDEFLQRMGELYECVLFTASLAKYADPVADLLDRWGVFRARLFRESCVFHRGNYVKDLNKLGRDLQQIIIVDNSPASYIFHPDNAVPVASWFDDMTDSELLDLIPFFEKLSNVENIYTVLCNSKHPYNQVPGGGTLQNNSSPGQGSMGAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HGB5</accession>
    <name>A0A8J2HGB5_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similar to tpsp: Bifunctional trehalose-6-phosphate synthase/phosphatase (Thermoproteus tenax (Strain ATCC 35583 / DSM 2078 / JCM 9277 / NBRC 100435 / Kra 1))</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS9238</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">In the N-terminal section; belongs to the glycosyltransferase 20 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5099795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HGB5"/>
    <dbReference type="OrthoDB" id="755951at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003825">
        <property type="term" value="F:alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004805">
        <property type="term" value="F:trehalose-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005992">
        <property type="term" value="P:trehalose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03788">
        <property type="entry name" value="GT20_TPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000113">
        <property type="entry name" value="Alpha,alpha-trehalose-phosphate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000324">
        <property type="entry name" value="Putative Alpha,alpha-trehalose-phosphate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000150">
        <property type="entry name" value="Trehalose-6-phosphate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001830">
        <property type="entry name" value="Glyco_trans_20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003337">
        <property type="entry name" value="Trehalose_PPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00685">
        <property type="entry name" value="T6PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10788:SF106">
        <property type="entry name" value="BCDNA.GH08860"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10788">
        <property type="entry name" value="TREHALOSE-6-PHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00982">
        <property type="entry name" value="Glyco_transf_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02358">
        <property type="entry name" value="Trehalose_PPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5099795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="791" mass="89279" checksum="5354AF38E819BEB5" modified="2022-05-25" version="1">MEMASKSPFRPFSERLKTNKSRSFSSNGSMIVVSNRLPFVLKRNEETGKLERKSSAGGLVTAVAPVVINGNGIWVGWPGMHMEDVNEQIPESDPNDKTPTAGLLSSKVVAVHVEPDKFDAYYNGSCNGTFWPLFHSMPDRATFNAEHWRAYVAVNEEFAAKTVKALEQIHEEQKSKPNGTPLVWVHDYHLMLAANWIRQAADEKNLKLKLGFFLHIPFPPWDIFRLFPWADEILQGMLGCDMVGFHIQDYCLNFVDCCQRCLGGRVDRKNLLVDHGGRTVRVRPLPIGIPFDRFVSLAEAAPKVIMTNLKIVLGVDRLDYTKGLVHRLKAFEMLLEKHPEHREQVTMLQIAVPSRTDVREYQELKLEMEQLIGSINGRFTTPNWSPIRYIYGCVSQDELAGFYRDSAVALVTPLRDGMNLVAKEFVACQINTPPGVLIVSPFAGAGEMMHEALICNPYEIDEAAEVIHRALTMPEDERTLRMNYLRRRERIYDVNYWMKSFLQVMGSLEEHDSVGATVMQPVTMDDFDDYLSKSPRYIGDDHKLALLLDYDGTLAPIATHPDLAILPLETKNVLQRLSNMPDVYIAIISGRNVNNVKSMVGIEGITYAGNHGLEILHPDGSKFVHPMPVEFEGKVGNLMQLLQDQQAKKLIEEAGFKACSAHCAIEAKPPVEWNKGRASIYILRTAFGLDWSERIRIIYAGDDATDEDAMKALKGMAATFRITSSHIVRTSAERRLPSTDSVLTMLKWVERHLGRRKPRNNSLDISNRFRRSSGGVTMEMSFTEPQHSLAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HH42</accession>
    <name>A0A8J2HH42_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to slim: Kelch domain-containing protein 10 homolog (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS5477</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5090067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HH42"/>
    <dbReference type="OrthoDB" id="7676067at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032874">
        <property type="term" value="P:positive regulation of stress-activated MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052125">
        <property type="entry name" value="KLHDC10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46428">
        <property type="entry name" value="KELCH DOMAIN-CONTAINING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46428:SF1">
        <property type="entry name" value="KELCH DOMAIN-CONTAINING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24681">
        <property type="entry name" value="Kelch_KLHDC2_KLHL20_DRC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5090067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="402" mass="46167" checksum="222B2534ECBBCE28" modified="2022-05-25" version="1">MSKTNKSTYKFKPFVFSQNEPASKEKPRARSGHRIVCDEKYLYSYGGYNPCIRDDDPELSNDEIWRESKPLFKELWRFNLTTRRWKLLPGRKSLPKELASTAVILRSNKLIIYGGTAEPFGESCNNRLYVCDLNDGSIIEPHVTGTLPDPQYGQALICHNSYLYTIGGTTGYDYTCDIHRIDLRTGLWERVYICTGRDPVEPGGRYRHELAYDGKLIYVLGGGTSSECFGFTEIPAFDLEKNCWLRLQTYGDLNNNPWIPHARRCHGCVQYVDQLTGDINVVISGGYTGPQVFNDVWRLNLRRLQWTCLKRFGTELPRPVYFHSAALTPAGQMYIFGGIVQNGSRGLRTQHVRSVWLVVPKLTEICWEAVNYYFKNLRTKSKDELTNLGIPLKFIQRLDIID</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HHM5</accession>
    <name>A0A8J2HHM5_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Similar to al: Homeobox protein aristaless (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HICCMSTLAB_LOCUS9035</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5098105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HHM5"/>
    <dbReference type="OrthoDB" id="6159439at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000047">
        <property type="entry name" value="HTH_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003654">
        <property type="entry name" value="OAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050649">
        <property type="entry name" value="Paired_Homeobox_TFs"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24329:SF543">
        <property type="entry name" value="FI01017P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24329">
        <property type="entry name" value="HOMEOBOX PROTEIN ARISTALESS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03826">
        <property type="entry name" value="OAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00031">
        <property type="entry name" value="HTHREPRESSR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50803">
        <property type="entry name" value="OAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 5 6" id="KW-0371">Homeobox</keyword>
    <keyword evidence="4 5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="8">
        <location>
            <begin position="98"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="OAR" evidence="9">
        <location>
            <begin position="333"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="5">
        <location>
            <begin position="100"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="199"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="247"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="250"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="264"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="297"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAG5098105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="360" mass="39100" checksum="4313670A40F33303" modified="2022-05-25" version="1">MDLSTTSTSNRNNQPVVLPVSITTITNKMTHRIAKSVFSIRSIVDVETRHNSTAQKPIDNQHSINIKLHYQDLDFLNGIRRKLLITVNLSKMSFINWSKNLREELAIKIGLTEARIQVWFQNRRAKWRKQEKVGPQGHPYNPYLSGTATQSSTVVTPTLPHPFAHLGTFALRKPFEGFRYTPLGPGPILSPSYGIGSGSGGISGVSGSSHPYHRPPPPMLSSPNMPGLSYSATAASFQTLLANISATQPPKIPLPGSSSPPPTSSSSKISASSPTASTSPTLPIIPSTSSVISLPPQSSTKSPVSITETRLPTESLSSETVKNIPADIDRRTNSIASLRLKAREFELHLEMLRKNGDLIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HIB6</accession>
    <name>A0A8J2HIB6_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 17">Alkaline phosphatase</fullName>
            <ecNumber evidence="3 17">3.1.3.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">HICCMSTLAB_LOCUS5992</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>a phosphate monoester + H2O = an alcohol + phosphate</text>
            <dbReference type="Rhea" id="RHEA:15017"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:67140"/>
            <dbReference type="EC" id="3.1.3.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="15">Binds 1 Mg(2+) ion.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="15">Binds 2 Zn(2+) ions.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 16">Belongs to the alkaline phosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.1" evidence="3 17"/>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5092236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HIB6"/>
    <dbReference type="OrthoDB" id="5818554at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004035">
        <property type="term" value="F:alkaline phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16012">
        <property type="entry name" value="ALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.720.10:FF:000008">
        <property type="entry name" value="Alkaline phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001952">
        <property type="entry name" value="Alkaline_phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018299">
        <property type="entry name" value="Alkaline_phosphatase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11596">
        <property type="entry name" value="ALKALINE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11596:SF5">
        <property type="entry name" value="ALKALINE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00245">
        <property type="entry name" value="Alk_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00113">
        <property type="entry name" value="ALKPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00098">
        <property type="entry name" value="alkPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00123">
        <property type="entry name" value="ALKALINE_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="8 17" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="10 15 17" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="18" id="KW-0732">Signal</keyword>
    <keyword evidence="9 15 17" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="18">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035268161" description="Alkaline phosphatase" evidence="18">
        <location>
            <begin position="23"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="active site" description="Phosphoserine intermediate" evidence="14">
        <location>
            <position position="103"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="59"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="59"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="166"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="168"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="329"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="334"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="338"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="375"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="376"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="456"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR601952-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR601952-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU003946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU003947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="CAG5092236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="524" mass="58068" checksum="021D583E83E7D28F" modified="2022-05-25" version="1">MSTYLTMSTLAILFFNFCLSAALEDASYWNSVASNELKESLSYSWNKNVAKNVILFIGDGMSVDTITASRIYRQGETGYLAWEKMPHVGMIKTYNTNKMVPDSASTATALFSGVKTNYKVVGVDNNVALDDCDGSLNPDFHTKSIIEWAQESGKDTGFVTTTRVTHATPAPLYAHCPNRNWECEAKIPTDAKGCKDIARQLIEDSPGKNIKVIMGGGRQMLKSNSSGTKIDPIDTWACYSQDGRHLMEDWASDKSARKFRHQIVQNNEQLRAVDPDDVDFLLGVFANGHLNMDWQRIDTPEGQPSLEEMTIMAIRVLRKAAKGFLLVVEGGLIDFAHHRGKAAQALRETVRFSDAVNATLEMVDLKDTLVIVTSDHSHSMAFNGYPDRNSSILGIAQNSKYDRIPYTTLSYSTGGPNNFAYEVKDNKSVRIDPSEFNTSDFNYSQQAAFIGDEAYHGGGDVPIYATGPYAHLFHSTHEQNYVAHVIGYAAQIGPYKNSSAQLGRKYIAIICSLTFIAFYCSKML</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HJ01</accession>
    <name>A0A8J2HJ01_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS9293</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5099905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HJ01"/>
    <dbReference type="OrthoDB" id="19174at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5099905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="250" mass="28619" checksum="9FFB5EBB0563FE0B" modified="2022-05-25" version="1">MDVNEPIITTGQFTGAATILVQLLVNNYKADVNATAADGTRSIHLVCFYQPHPKQIGLFIKGHTYGAIIYTLVQTNANADAEFGRDIFLKHFEDSDWCPDFEAKINENIISLKNKTLLMYALESAHDELFMEFIEKLFKGPTKLINHRDNYGVPATHYLVHPKQYGNSTFLPNLVAYRGYSGLLKTILPYYTDMSLSNRVLYYATLPIDENSDDLFRPHPTDYVERSRYLEKIRIKRQESIQVAGRRFGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HJ22</accession>
    <name>A0A8J2HJ22_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similar to Syn: Synapsin (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS11303</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5103025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HJ22"/>
    <dbReference type="OrthoDB" id="8123786at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="28"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5103025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="133" mass="13789" checksum="082497AD1E0220DB" modified="2022-05-25" version="1">MSGVSQTASPVEERGPPPGQAPVLSSHGSIGSITSAVSTGSTSSTSAQAPILSSDVNGSDIHQLQRRDSQVSQSSATSNAPPASRRSDEPPPLPPSRISFHRQGSQSQATPSEDTEDTMKNLRKTFAGIFGEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HJ71</accession>
    <name>A0A8J2HJ71_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">TLDc domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS11324</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5103067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HJ71"/>
    <dbReference type="OrthoDB" id="289228at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006571">
        <property type="entry name" value="TLDc_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07534">
        <property type="entry name" value="TLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00584">
        <property type="entry name" value="TLDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51886">
        <property type="entry name" value="TLDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TLDc" evidence="2">
        <location>
            <begin position="277"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="28"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5103067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="489" mass="55896" checksum="95ED7BC2F903811E" modified="2022-05-25" version="1">MGNHSTRHNDKLEQKHIHSATTTNNKVSKSISRSTSSNEIEQNFTTHFLPIDKLSKILAEHSEYEDSVHHGISENVFVKYLFPHYPQLGSRLFKYLLASSQKVSSKYLGTSTFKQEVEKLLSLMNDQIILDTYVKIYCHSYENSNMTPETLKELLMISYQSATESEPNTCPYILETINTVITSCFHGKENLSICYVSNWLSQHCPRVVSGVHKAIVHIFTIAYRYGKKLLSTGELQLRVESVTPVLEKAVFFDKPENLLPLSHVWLLSISLPLTYIQTEDSSPENNMAKTLPISRSPCPSHWTLLYSSDEHGTGANRFLHHVLGYRGPTIVIIKGDNGSNGHATYCICNAVEWRESHLYWGDADSVILELYPTYKIFQKKSKILYLNTGIRGYPYGLRAGDDPRNPIINIDQSFHSINFEGAPHRITSIEVWGCGDRKSRERQLEVKKWQLQEVEKQRVVKLSPNDWLDHPDRYLLELAGRQSYNNASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HJI5</accession>
    <name>A0A8J2HJI5_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Similar to Tbp: TATA-box-binding protein (Bombyx mori)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HICCMSTLAB_LOCUS9187</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TBP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5099693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HJI5"/>
    <dbReference type="OrthoDB" id="2127950at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000992">
        <property type="term" value="F:RNA polymerase III cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001092">
        <property type="term" value="F:TFIIA-class transcription factor complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042797">
        <property type="term" value="P:tRNA transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd04516">
        <property type="entry name" value="TBP_eukaryotes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.310.10:FF:000005">
        <property type="entry name" value="TATA box-binding protein-like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.310.10:FF:000002">
        <property type="entry name" value="TATA-box-binding protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.10">
        <property type="entry name" value="TATA-Binding Protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00408">
        <property type="entry name" value="TATA_bind_prot_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000814">
        <property type="entry name" value="TBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030491">
        <property type="entry name" value="TBP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012295">
        <property type="entry name" value="TBP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033710">
        <property type="entry name" value="TBP_eukaryotic"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10126">
        <property type="entry name" value="TATA-BOX BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00352">
        <property type="entry name" value="TBP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00686">
        <property type="entry name" value="TIFACTORIID"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55945">
        <property type="entry name" value="TATA-box binding protein-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00351">
        <property type="entry name" value="TFIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="37"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="53"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAG5099693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="245" mass="27150" checksum="B526E8AF3E664F81" modified="2022-05-25" version="1">MSGQNDELKRLLGSPSPGRGSEDNVMAPPLSTNVPKPSSTQSSTSSNNNNPQASMTASTPATGQKEVLEPVIQNVVSTVNLETELNLMKINACTRNSEYNPARFTGLVMRIRNPRATALIFRSGKLVCTGARCEEDSYLATRKFARIIQKIGFHVKFKDFKIQNIVATCDLKFPIKLESLCESHGNFTSYEPELYPGLIYRLIAPRIVLLIFVNGKIVMTGAKDREDLTTALSKIYTTLLSYRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HJM6</accession>
    <name>A0A8J2HJM6_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS10115</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5101042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HJM6"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035228679" description="Secreted protein" evidence="1">
        <location>
            <begin position="22"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5101042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="91" mass="9787" checksum="B872C647384254C0" modified="2022-05-25" version="1">MAVITLLWKWTIVCFVGVGVGGRGFGGNGVEKVEASDRIGTSLAFTRASVHSCRWARTTVDKFVRLDAAESSEVECTLYFTVDDVVSPVSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HJQ4</accession>
    <name>A0A8J2HJQ4_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to wdr5: WD repeat-containing protein 5 homolog (Dictyostelium discoideum)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS9325</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5099982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HJQ4"/>
    <dbReference type="OrthoDB" id="361494at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47822:SF3">
        <property type="entry name" value="ANAPHASE-PROMOTING COMPLEX SUBUNIT 4-LIKE WD40 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47822">
        <property type="entry name" value="CARBOHYDRATE BINDING DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="182"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="236"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="7"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5099982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="406" mass="45422" checksum="4CC983A313052B4D" modified="2022-05-25" version="1">MEKLKKNGSQIKSNKTSRTSLSKSTMTETTESIAADSSRADTISKSSSRRDSFFLIDRRISEEESQRRYSWLQKTRLSIASTRNQARLIHEVKFPDTFGGLYSAKYSPRGDLIATGFGTGAIQIRNGENGEFRTTLRSGLDTSLPVMCCRFNPFYDNIFYASSACGNIFLCMTDTNVFSRFIQEPNNEINTIDVSLDGKFIVSGGKDAALRLYDAQTAKLIHTYGRNEADLTDENDNYHRMRIFSAKFHHIYENLIITGGWDDTLRIWDRRVDSGSIKVMKGPHICGDAIDIRDTKIITGSWVVRGSLQLWDMTTAKLIETIVPENRPTSLDGEFIYAVQYFDGDPYGEHVLAGGSGTGALEVINIKDKKVVGNFEVSKAIMTIDSNRSSIIFGGMESVLRLADFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HKQ3</accession>
    <name>A0A8J2HKQ3_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Actin-related protein 2/3 complex subunit 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HICCMSTLAB_LOCUS7643</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the ARPC5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5095306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HKQ3"/>
    <dbReference type="OrthoDB" id="429520at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005885">
        <property type="term" value="C:Arp2/3 protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034314">
        <property type="term" value="P:Arp2/3 complex-mediated actin nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030833">
        <property type="term" value="P:regulation of actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.190">
        <property type="entry name" value="Actin-related protein 2/3 complex subunit 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006789">
        <property type="entry name" value="ARPC5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036743">
        <property type="entry name" value="ARPC5_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12644">
        <property type="entry name" value="ARP2/3 COMPLEX 16 KD SUBUNIT P16-ARC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04699">
        <property type="entry name" value="P16-Arc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039096">
        <property type="entry name" value="p16-ARC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69103">
        <property type="entry name" value="Arp2/3 complex 16 kDa subunit ARPC5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004301"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAG5095306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="144" mass="16295" checksum="9C5221C2BCAAEC05" modified="2022-05-25" version="1">MSRIEDKKDTMGTGFRKIDIDEFNENNFKEEEADASLTGTTGKHAEALISALKAAPLESKNQQVKDNARNVTQKILLSIKSNQMDDVIAQLDRELMDVLMKYIYRGFEIPSKDSSSHLLLWHEKVYSISGIGSIVRVFTDSKRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HL21</accession>
    <name>A0A8J2HL21_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS9845</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5100772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HL21"/>
    <dbReference type="OrthoDB" id="6412801at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.15.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.15.10.30">
        <property type="entry name" value="Haemolymph juvenile hormone binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017943">
        <property type="entry name" value="Bactericidal_perm-incr_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010562">
        <property type="entry name" value="Haemolymph_juvenile_hormone-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038602">
        <property type="entry name" value="Mite_allergen_7_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020234">
        <property type="entry name" value="Mite_allergen_group-7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038606">
        <property type="entry name" value="To_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11008:SF13">
        <property type="entry name" value="FI04421P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11008">
        <property type="entry name" value="PROTEIN TAKEOUT-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16984">
        <property type="entry name" value="Grp7_allergen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06585">
        <property type="entry name" value="JHBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00700">
        <property type="entry name" value="JHBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55394">
        <property type="entry name" value="Bactericidal permeability-increasing protein, BPI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035318657" evidence="2">
        <location>
            <begin position="19"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="440"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="453"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5100772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="464" mass="51737" checksum="DC93171F91B5AF37" modified="2022-05-25" version="1">MEFIQLFIFIGGIFLCSCNTNGNDTKTKLAQGEKQLGDQIRLILKHYQQPDPIGLPGAPIPDPMTVPDMKHSFSMYTMTFKSVKVYGLSKFRIEHVQSEIALMQVSVALSIETLDIRGLYTLSSWLSGSSGDFTVKLTGVNIQGLAKLQVGTDGKLHAQDIDMDLTFVNIDMDFKNLGFLGAVLQSVLNSVGAFIFDSIKPFILNEVNTNIRGEVNKQISQLPQYFPNSISPFDMAVAEARKQVSDMGYDPYRLKDYSQSVGIFTVTSSYTWITGLASFYRMGNITLSMENGTVYALLDVGTQEIEGKTHWEVGVIGGFLSRAGTVSFTVQYFRVQVKLSQPVDTRKRASLEELNLELGNIQTRIHGAGTVDYIIEAGINILPNLLRYQIMDAIEGPIRRRLQDELDKVDVEKLIHEKIPEIEEKARFLQGITPSEDIILEESAPPLPLDQEPFSESEEERGPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HLA7</accession>
    <name>A0A8J2HLA7_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS9767</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5100694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HLA7"/>
    <dbReference type="OrthoDB" id="7699805at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33332">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5100694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="365" mass="42158" checksum="708FB2D956A2E713" modified="2022-05-25" version="1">MFLSSSSHILTALYELGFSLDTIAWFLSYLSNRSQSILDDHGTPIQLLTTSSGPSQGSVLGPILFLIVINSVVRWLIYCKHGLFADDTYIYQHFFIHQFEEAVRQVNLDAQSIANSANAHGLELNLSKTKAMILGSNGRLRQLQEFDSKKICIVILYIDSVKCLGVYIDRSLSWNTHVSQVVRKVNSALHCLKVRKNIFTKELRKILVTATILPLLDYCSAVLVDATAEKDRKLQHALNASIRFIFDLRRDVHISPYRKDLSWLSVKYRRMYFMTCLLYKLLSVGKPNYLRNLFVKEADIRRSDRLAAKKHTSFELPRFTKTYLEHSFLVIVIRVWEELPSDIVNSDSLEVFRNKVFDYFLELDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HLJ3</accession>
    <name>A0A8J2HLJ3_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Gustatory receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HICCMSTLAB_LOCUS10700</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Cell membrane</location>
            <topology evidence="1 8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the insect chemoreceptor superfamily. Gustatory receptor (GR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5101808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HLJ3"/>
    <dbReference type="OrthoDB" id="6366728at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030425">
        <property type="term" value="C:dendrite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043025">
        <property type="term" value="C:neuronal cell body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007635">
        <property type="term" value="P:chemosensory behavior"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008049">
        <property type="term" value="P:male courtship behavior"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050909">
        <property type="term" value="P:sensory perception of taste"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013604">
        <property type="entry name" value="7TM_chemorcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21143:SF133">
        <property type="entry name" value="GUSTATORY AND PHEROMONE RECEPTOR 32A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21143">
        <property type="entry name" value="INVERTEBRATE GUSTATORY RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08395">
        <property type="entry name" value="7tm_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 8 9" id="KW-0675">Receptor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="43"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="78"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="131"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="170"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="266"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="300"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAG5101808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="402" mass="47275" checksum="98D16EE3C0D7763A" modified="2022-05-25" version="1" fragment="single">LFKFTMWKPANFIEAMSPIFFINAIFCHGIFQYPHLDKSKLYYSLIFSITTTIVFFMFFMYVFLNWTDRFFLTSPKGIYYVNTGIMILAMIINVIVGWTHKNKTLATNLRVIKVDKTLKKLGVPVNAKKEFYIIIMIVFIWILFVLFLDISNIVATEKSDDRSEKIMRTVILQHGHHVNILINTIFCLFVKHMKIRFKSLNKVLLDIFKLQDNDSKHKKNTDYKWAVSRKINFEKDFMKILHDVKRIHLELGILCREITKIYGIPIVLSMITAFINISSLTLITYMIIMSPQDPNFDKSVIVSSLLLWVIVFSLRIFIINYNCADCEFEWKKTGEIIHTLEFDSKNKEFQEEIKQFSIQILQNPLKFSPCGLFDLGYYFLRDFAGTVTAQVILSIQTYRFTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HLN4</accession>
    <name>A0A8J2HLN4_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Pre-mRNA-splicing factor RBM22</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">RNA-binding motif protein 22</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">HICCMSTLAB_LOCUS12320</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SLT11 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5106559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HLN4"/>
    <dbReference type="OrthoDB" id="10259600at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071006">
        <property type="term" value="C:U2-type catalytic step 1 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071007">
        <property type="term" value="C:U2-type catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036002">
        <property type="term" value="F:pre-mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017070">
        <property type="term" value="F:U6 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12224">
        <property type="entry name" value="RRM_RBM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000137">
        <property type="entry name" value="pre-mRNA-splicing factor RBM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1000.10:FF:000006">
        <property type="entry name" value="Putative pre-mrna-splicing factor rbm22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039171">
        <property type="entry name" value="Cwc2/Slt11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048995">
        <property type="entry name" value="STL11/RBM22-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057674">
        <property type="entry name" value="Znf-CCCH_RBM22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14089">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR RBM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14089:SF6">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR RBM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21369">
        <property type="entry name" value="STL11_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25584">
        <property type="entry name" value="zf-CCCH_RBM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="12" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 15" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="8" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="10 16" id="KW-0862">Zinc</keyword>
    <keyword evidence="9 16" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="19">
        <location>
            <begin position="159"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="18">
        <location>
            <begin position="232"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="16">
        <location>
            <begin position="159"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="393"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00030793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="CAG5106559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="420" mass="46796" checksum="BF1EE284139DD4C6" modified="2022-05-25" version="1">MAMSKTTNTYNRQNWEDAEFPILCQTCLGDNPYIRMTKEKYGKECKICIRPFTVFRWCPGARMRFKKTEVCQTCSRLKNVCQTCLLDLEYGLPIQVRDAALKVKDDLPRSEVNKEYYVQNIDKEIGNIDPTSPAGAVGKSAAASDLLMKLARTSPYYKRNRPHICSFWVKGECKRGEECPYRHEKPTDPDDPLADQNIKDRYYGVNDPVADKLMRRAAAMPTLEPPEDKSITTLYIGGLGDILTEKQLRDHFYQYGEIRSVTMVPRQQCAFIQYTQRAAAELAAERTFNKLILGGRRLIIKWGRSQGRQTISAVEATREMLEPVPGLPKPLPPPESLGNNFFNLQGATGIMPPIIIPPPPVAPQFLFPSQIATAAAAAAAAAASAATPIFPPGTAPIHYPSQDPSRMGASQGIGKPWPED</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HLQ2</accession>
    <name>A0A8J2HLQ2_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Odorant receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HICCMSTLAB_LOCUS10009</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Cell membrane</location>
            <topology evidence="1 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the insect chemoreceptor superfamily. Heteromeric odorant receptor channel (TC 1.A.69) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5100936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HLQ2"/>
    <dbReference type="OrthoDB" id="7540137at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005549">
        <property type="term" value="F:odorant binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004984">
        <property type="term" value="F:olfactory receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004117">
        <property type="entry name" value="7tm6_olfct_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21137">
        <property type="entry name" value="ODORANT RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21137:SF35">
        <property type="entry name" value="ODORANT RECEPTOR 19A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02949">
        <property type="entry name" value="7tm_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 10" id="KW-0552">Olfaction</keyword>
    <keyword evidence="8 10 11" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="9 10" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="54"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="88"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="144"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="204"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="284"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="317"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU351113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAG5100936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="411" mass="46669" checksum="28A369D3C7CC5ECF" modified="2022-05-25" version="1">MENKNNSNSQSKTFKYQNLNYKSDSNYAVKVARTLLTPLGIYPLHGSDTSLSKFLVKIQIIIVFGLMLFLLVPHFIWTFFDAEDLKKLMKIIAAQIFNSLALIKFWTMIIHKKELRNCLIQMDNNWKNVLCEEDRLIMVKNAKIGRFFTIAYLSLSYGGALPYHIFLPLSAERIVKEDNSTQIPLPYPTDYVFFVPEDSPGYEMLFVTHIIISTMILSTNCGIYSLIATYITHGCCLFEVVCRHLDEFSKNSTNVALKKELSWIVENHNRAIEFAAVLESSLNVVFLCEMVGCTVIICFLEYGVIIDWEDGQLLGLVTYAILMTSIFVNCFIISFVGERLKEQSLRVGERAYAAHWYSLPKSFAYDLMLIVIRTSQPVTLSTGKVSDLSLAGFAGLVKTSAAYLNFIRAVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HMQ1</accession>
    <name>A0A8J2HMQ1_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS11534</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5103487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HMQ1"/>
    <dbReference type="OrthoDB" id="5979581at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="349"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="299"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="130"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="159"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="315"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5103487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="404" mass="44584" checksum="2D992962A8E7F8AC" modified="2022-05-25" version="1">MWNVAMRYDEPKESPTHRRSSVPAIEFASPILPGTPAGDEEEQAVAGRLEIRVVDSTGGATVVQTTADKEPLQKKLTNGTAGSPASPNPGPDEPSIYYDATESRVNTSNTSANKPVTAPIAPNSNPVTPREPKDNKDRDNSRPHSAYSKIPVPVKSPRCSLSESTPDANTPNTKTGTGSELEKSPTTSTQLKDKESATKGKLITVHTMETPQLRRCATLPDARPNPVPPLMSTSSTEDENLTGCTPALRRRRQSEKYVTHASQLNLRFQRPQRRRPSSEVLSKFYPRGVPSYLLEAGKRNEESSDNDSDSSGPPNTQPPPPPSSLPPHVAENNARYGRYHQTIFNSTDFYYWLPLQTFMEFLALPPSITILFFLVLYYLSMISYYHLLCNILNVSVSFSVLQID</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HNQ9</accession>
    <name>A0A8J2HNQ9_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Peptidase A2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS11220</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5102860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HNQ9"/>
    <dbReference type="OrthoDB" id="7700397at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5102860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="114" mass="13181" checksum="1D0CB9EF403C7E5F" modified="2022-05-25" version="1">MLFEIDTGASISAISKEKLDQIGQLKYLLLIKTPRKFQSYQGSVMTPLGVLKVDAKHRHHSERLDLYVFGGRNKPIIGRDWIKTFDLIAVNMKPRESIYFISSREKYVRKLLNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HNW5</accession>
    <name>A0A8J2HNW5_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Similar to Dgk: Diacylglycerol kinase 1 (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HICCMSTLAB_LOCUS11248</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5102916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HNW5"/>
    <dbReference type="OrthoDB" id="7699805at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061343">
        <property type="term" value="P:cell adhesion involved in heart morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007508">
        <property type="term" value="P:larval heart development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33395:SF22">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33395">
        <property type="entry name" value="TRANSCRIPTASE, PUTATIVE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="507"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="432"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG5102916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="570" mass="65233" checksum="1F171B4C630259BA" modified="2022-05-25" version="1">MAHFCEFQDFFRLNPYHVIGVVESWLCDAIADQQVNLPGYALLRVDRHNKRGGGVMLYVRKELNARLLSSSAGAGEIILPEYLTAEIWGPSQYKILVAIVYRPPKSGYMNIFEDDFSMRMINYKFTCVLGDFNADLHVRSDKTARLKDFFTRSGMSVVPMQPTNHTAQANTWIDVCAVSQLSSLESWGQSGQPFLSSHDLIYICLKYEHPKPVRHRIKCLSWKEADLAAAGEIVDQRIDELNADLDDSQQSVDQCLHSLNMIIQDIVKNCVPVREFTAKHRPAPWITPELRDLRRERDRSYRRFKRSGHPLVWENYVRFRRQSQLLWKKEQGNYLQSVFSRAGQTKNFWIEMDRLGLSVSSSKSRAPLKFDIDELNDYYVAIIQGRKLPSFEDSVASVDRSRLNEWFTFSRASAPDVVKHLPVGSSRAKGVDNLPVQVPDSSNGRAADMSSEGSGYESQSELSNIFFSHILYTHIKKFLSTILSQFFPTKISCYVNVGKLHVICILMFRLYDTDGNGVLDTNEMDCIVNQMMNVAEYLGWDVSELKPVRRNLFTRSFGTKYGALCSRNSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HNX0</accession>
    <name>A0A8J2HNX0_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS11959</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5104352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HNX0"/>
    <dbReference type="OrthoDB" id="9445768at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="18"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5104352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="172" mass="19686" checksum="39D86D439BA8D81B" modified="2022-05-25" version="1" fragment="single">ALSDNNNSSDSNALDNELKQTYEYLKDIEAELLEQKNEFISLLSKNPIETVSPNVKPEDIEAEQLKFVKALVNEEQDYDDRIRPIKNSVDVFTSLDSALLQEISDIQTILDQTKVQFLDVKKSISSLMSEKNNLQKMKDMCSDAVENVDAETTDIAMYHRNDRNKIRLVDLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HPB9</accession>
    <name>A0A8J2HPB9_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7">Vacuolar protein-sorting-associated protein 36</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6 7">ESCRT-II complex subunit VPS36</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HICCMSTLAB_LOCUS11673</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the ESCRT-II complex (endosomal sorting complex required for transport II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of the endosomal sorting complex required for transport II (ESCRT-II).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Endosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the VPS36 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5103765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HPB9"/>
    <dbReference type="OrthoDB" id="271448at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000814">
        <property type="term" value="C:ESCRT II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032266">
        <property type="term" value="F:phosphatidylinositol-3-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043328">
        <property type="term" value="P:protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000170">
        <property type="entry name" value="Vacuolar protein-sorting-associated protein 36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000416">
        <property type="entry name" value="Vacuolar protein-sorting-associated protein 36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021648">
        <property type="entry name" value="GLUE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040608">
        <property type="entry name" value="Snf8/Vps36"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037855">
        <property type="entry name" value="Vps36"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13128">
        <property type="entry name" value="VACUOLAR PROTEIN-SORTING-ASSOCIATED PROTEIN 36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13128:SF12">
        <property type="entry name" value="VACUOLAR PROTEIN-SORTING-ASSOCIATED PROTEIN 36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04157">
        <property type="entry name" value="EAP30"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11605">
        <property type="entry name" value="Vps36_ESCRT-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51495">
        <property type="entry name" value="GLUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0967">Endosome</keyword>
    <keyword evidence="5 7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="GLUE N-terminal" evidence="8">
        <location>
            <begin position="1"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00030114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU367095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAG5103765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="354" mass="39904" checksum="34400AA197DCB661" modified="2022-05-25" version="1">MNRFEYAEARLMPNEIFVRRNMSIRIYDGDTKTNFAGGELVLTSHRLIWGRPGDIPNGKVCLSLSLRYVIFFEEEAPSTFSFGRSKKIILHLAEPPISKSPGPVDNSTNMHIKLSFKEGLDPNYITQLADVIMKKQWEVIISSPIIEPEATNPQKSQLPVIKTRTGIIGIERGLQEKQKATDQSITMAFQDLKKLMEMAKDMVSISKTISNKIRERQGDITEDETEVGGMMTLTDAYCRVNRARGLELLSPEDLLNASRQLGPLNQPLVLRIFDSGVMVLQARSHDDNAVIEDIAELLDDRGSITAEELAQSSGISVLLARERLLVTEKYGRACRDDSIESLRFYPNLFLRQET</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HPM4</accession>
    <name>A0A8J2HPM4_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SPRY domain-containing protein 7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS12968</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5107899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HPM4"/>
    <dbReference type="OrthoDB" id="40953at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd12880">
        <property type="entry name" value="SPRYD7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035766">
        <property type="entry name" value="SPRYD7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20951">
        <property type="entry name" value="C13ORF1 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20951:SF2">
        <property type="entry name" value="SPRY DOMAIN-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B30.2/SPRY" evidence="2">
        <location>
            <begin position="1"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00021772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5107899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="194" mass="21313" checksum="A968A9FFF2431F34" modified="2022-05-25" version="1">MMFCCLKNCFNGLGFTGVKAPQKEFNPITLDTSHMGHEVVVVMNGLRVCGQGCALTNVPLVQSKSYFEVKIRQDGMWAVGLATRSTNLNTTVGGNDADSWAFNSDGIIRHNQQEIHKITNLPQEGDVIGVSFDHIELNFYINGKNINAPVMGIKSTIYPALYVDDGAILDLILQDFVHPPAPGFEKIMVEQSLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HPQ7</accession>
    <name>A0A8J2HPQ7_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Similar to PUDP: Pseudouridine-5'-phosphatase (Homo sapiens)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS10666</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5101765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HPQ7"/>
    <dbReference type="OrthoDB" id="40579at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.240:FF:000001">
        <property type="entry name" value="Haloacid dehalogenase-like hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="entry name" value="Putative phosphatase, domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18901">
        <property type="entry name" value="2-DEOXYGLUCOSE-6-PHOSPHATE PHOSPHATASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18901:SF38">
        <property type="entry name" value="PSEUDOURIDINE-5'-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01129">
        <property type="entry name" value="C1.5:_HAD__Beta-PGM__Phosphata"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5101765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="262" mass="30393" checksum="DABC2891722239CD" modified="2022-05-25" version="1">MANYKNVTHCLFDMDGLLIDTEYRYTEAYNKVLNKYGKNFSWELKASIMGFHFNEAAKRVVEFLELPITPEELMDQVTPYYDILFPDSQLMPDSESVYKTIYNKIISKFGHNYEGEVVFQVLGRPEAVGINLIIDYFKLPLSFEEQQIYRIQNVMYHFLNLLSSRAERLLRHLVKHNIPIALATSSSEKSYELKTRKLKPFFELFHHRVLGGSDPDVKHGKPAPDIFLVAASRFSDSNPVQPSQVLQWLVVLASEEFLLTQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HQW0</accession>
    <name>A0A8J2HQW0_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Mannosyltransferase</fullName>
            <ecNumber evidence="8">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HICCMSTLAB_LOCUS12911</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Endoplasmic reticulum membrane</location>
            <topology evidence="1 8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the glycosyltransferase 22 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="8"/>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5107773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HQW0"/>
    <dbReference type="OrthoDB" id="416834at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000026">
        <property type="term" value="F:alpha-1,2-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005599">
        <property type="entry name" value="GPI_mannosylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22760">
        <property type="entry name" value="GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22760:SF4">
        <property type="entry name" value="GPI MANNOSYLTRANSFERASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03901">
        <property type="entry name" value="Glyco_transf_22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="2 8 9" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="65"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="163"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="203"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="250"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="334"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAG5107773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="484" mass="56626" checksum="5D7E34AFAF0E5EB1" modified="2022-05-25" version="1">MVPGIHEMLEKNLLWLIIIVKIIVLCFVTNDCDPDGNWQNLEVAHLQAFEYGYRTWEWRSMTHSYIYPFIISIIYKILAIVGLDYPLMIIYSPRIFQAVLSAFAEYRLLKWTNSPEAASLLVLNGFWQFCSTKTLDHTLEASLMIIALSIYPWEDKDKHGSKFIWLMGFMFFIKPTSAIMCVPLYIRHMYNSDKTIKQLIKDYFFIGMCVSGIAIAIDSYCYGQLVVTPWEFLKTNIFTGIGNHYETKYILWYIHITIPYFLGFGMFTLPFVFMKLFFNEMDDERQETSIIIFCWTILWNSLLPHKEHHFLLSLLPLLVFLSAKFEWSEVTNKLISSILILITIIINIGIFYSFANDRSGATEIMSYLREEIASSPSNVDVMFLTPCYSTPLYSHVHKDIPMELLNCDPNLKNQDNYLNEADIFFNDPMTWLEKRYTNSTLPFFVVIYDNLAPRIKGFVDNYHLVVSVFDSFYPSTNRVNDNNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HRP8</accession>
    <name>A0A8J2HRP8_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Apolipoprotein D</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HICCMSTLAB_LOCUS13731</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the calycin superfamily. Lipocalin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5109095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HRP8"/>
    <dbReference type="OrthoDB" id="565904at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007420">
        <property type="term" value="P:brain development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006869">
        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000302">
        <property type="term" value="P:response to reactive oxygen species"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042246">
        <property type="term" value="P:tissue regeneration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19437">
        <property type="entry name" value="lipocalin_apoD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.128.20:FF:000003">
        <property type="entry name" value="Apolipoprotein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002969">
        <property type="entry name" value="ApolipopD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012674">
        <property type="entry name" value="Calycin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022271">
        <property type="entry name" value="Lipocalin_ApoD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000566">
        <property type="entry name" value="Lipocln_cytosolic_FA-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10612">
        <property type="entry name" value="APOLIPOPROTEIN D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10612:SF34">
        <property type="entry name" value="APOLIPOPROTEIN D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08212">
        <property type="entry name" value="Lipocalin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036893">
        <property type="entry name" value="Lipocalin_ApoD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01219">
        <property type="entry name" value="APOLIPOPROTD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50814">
        <property type="entry name" value="Lipocalins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="10" id="KW-0873">Pyrrolidone carboxylic acid</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 11" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035350822" description="Apolipoprotein D" evidence="11">
        <location>
            <begin position="20"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="Lipocalin/cytosolic fatty-acid binding" evidence="12">
        <location>
            <begin position="36"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR036893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF08212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAG5109095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="193" mass="21489" checksum="FCAC0878CC6A3BA8" modified="2022-05-25" version="1">MKTLFVITFTSVVINGALAQSFNLGPCPKVNTVENLDIERYSGLWYENERSFPMIFELGGRCVTANYSANSDGTVKVVNSQISSITGSESSITGTARVNDEACNNTTCGKLIVTFPIPVIGEVDGTYWVLETDYTTYSVVWSCTDYKAFHISYAWVLTRDRNPSEAVVKQATSLYENDNPEYIFMTKTDQENC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HRQ0</accession>
    <name>A0A8J2HRQ0_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS14095</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001859">
        <property type="protein sequence ID" value="CAG5110734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HRQ0"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5110734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="163" mass="17904" checksum="FA5338DD7C3D6191" modified="2022-05-25" version="1">MSCGKNTEATPVCSKDNCQCQGALVGANLCHGALHAYLELQTLGFCNSEVRWKPNFCQGVQNANPIHHLLGGCKMERGMSQISGLCGHIQHSCLLKTVVAVRLASQMSSNVKLRQVMLSYVSNKVLHVQPEFKSLRDCVNGVRCELDLENTLEDCQAISEKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HRX3</accession>
    <name>A0A8J2HRX3_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SERTA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS12694</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5107328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HRX3"/>
    <dbReference type="OrthoDB" id="8735401at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052262">
        <property type="entry name" value="E2F-SERTA_domain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009263">
        <property type="entry name" value="SERTA_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16277">
        <property type="entry name" value="CELL DIVISION CYCLE ASSOCIATED PROTEIN 4/SERTA DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16277:SF7">
        <property type="entry name" value="RE12330P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06031">
        <property type="entry name" value="SERTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51053">
        <property type="entry name" value="SERTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SERTA" evidence="2">
        <location>
            <begin position="165"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="233"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5107328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="363" mass="40405" checksum="762931969498BB8B" modified="2022-05-25" version="1">MMGLQATAGKRKLEGGVGCMEFDMDMGESPSKLGRVEGSWWAMEDSYTPPLNQSSSYYEMEVSSPCLQGNPCQPTGNLPPAGPQLHHPPQHYYHQRSSPPGGNGGYNQLSRPQPQWGAPHHYEPPTIRREENGKSYLELGSSYRANERCCEGSRTSWCRRGRACYRQRRLAVLNISMCKLARYRQFPDPSLHRSVLICNTLRHLEREMERDRSPPPMEPVIPAPMAQLQHPEQGRLTPFPIPPTASNETDVDSGIGDSDDSRSINWGSVLSLSSQSPLDPLNNNELLDVDIGPEIDLDFMPGWKLTPLSADDILRSTNVQDHHLNTTNNISSTINNNNNNHIITSNNSCNSSSTHESLMCVGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HS13</accession>
    <name>A0A8J2HS13_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">5-aminolevulinate synthase</fullName>
            <ecNumber evidence="6">2.3.1.37</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">5-aminolevulinic acid synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Delta-ALA synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Delta-aminolevulinate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HICCMSTLAB_LOCUS13913</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>succinyl-CoA + glycine + H(+) = 5-aminolevulinate + CO2 + CoA</text>
            <dbReference type="Rhea" id="RHEA:12921"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:356416"/>
            <dbReference type="EC" id="2.3.1.37"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="6">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; 5-aminolevulinate from glycine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.37" evidence="6"/>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5109277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HS13"/>
    <dbReference type="OrthoDB" id="10263824at2759"/>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00375"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003870">
        <property type="term" value="F:5-aminolevulinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048821">
        <property type="term" value="P:erythrocyte development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042541">
        <property type="term" value="P:hemoglobin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06454">
        <property type="entry name" value="KBL_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000006">
        <property type="entry name" value="5-aminolevulinate synthase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010961">
        <property type="entry name" value="4pyrrol_synth_NH2levulA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050087">
        <property type="entry name" value="AON_synthase_class-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01821">
        <property type="entry name" value="5aminolev_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13693:SF102">
        <property type="entry name" value="2-AMINO-3-KETOBUTYRATE COENZYME A LIGASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13693">
        <property type="entry name" value="CLASS II AMINOTRANSFERASE/8-AMINO-7-OXONONANOATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="4 6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="7">
        <location>
            <begin position="158"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU910713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG5109277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="529" mass="58317" checksum="7A5F0CE97E2F28D8" modified="2022-05-25" version="1">MIRQGFIQVTYHLAGAVKGKADVMPCPFLTRLSANYVRNYSALLITNYRQYCPVMSRLSSTLADTETETAKVKPAIKQCPFLLKEPDAVKEASSAVEEDIISLGDSKNEEKSFPYEEYFHEQIVKKKKDHSYRVFKKVNRLAQEFPTAMEYSWGEKPITVWCSNDYLGMSRHPAVTGSVRKALDKFGAGAGGTRNISGNSMGHEMLEKRLADLHQKEAGLLFTSCFVANDSTLFTLAKSLPGCHIFSDSGNHASMIQGIKNSGVPKHIFRHNDVRHLEEMLSSIDRSLPKIVAFETVHSMDGSICPLEEMCDIAKKYGAITFIDEVHAVGLYGYSGAGIGERDRVLHKMDIISGTLGKAFGNVGGYIVGSSTLIDMIRSYAAGFIFTTSLPPTVLYGALAAVEILASDEGRALREMQQQNVAYLKSTLTSAGLPLQQSPSHIIPVKVGDPLVCSQIADALLKNKGHYIQAINYPTVAKGEEKLRIAPTPKHSPEMIDKFVQDLLDVFNQLNVPKLPRSSEHFVQAIKVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HS61</accession>
    <name>A0A8J2HS61_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Mitochondrial (Culex quinquefasciatus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HICCMSTLAB_LOCUS12288</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5106494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HS61"/>
    <dbReference type="OrthoDB" id="198619at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032790">
        <property type="term" value="P:ribosome disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16262">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03713">
        <property type="entry name" value="EFG_mtEFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04088">
        <property type="entry name" value="EFG_mtEFG_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.240:FF:000001">
        <property type="entry name" value="Elongation factor G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.870:FF:000005">
        <property type="entry name" value="Ribosome-releasing factor 2, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000514">
        <property type="entry name" value="Ribosome-releasing factor 2, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.870">
        <property type="entry name" value="Elongation Factor G (Translational Gtpase), domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053905">
        <property type="entry name" value="EF-G-like_DII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041095">
        <property type="entry name" value="EFG_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009022">
        <property type="entry name" value="EFG_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035649">
        <property type="entry name" value="EFG_V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005517">
        <property type="entry name" value="Transl_elong_EFG/EF2_IV"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43261:SF1">
        <property type="entry name" value="RIBOSOME-RELEASING FACTOR 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43261">
        <property type="entry name" value="TRANSLATION ELONGATION FACTOR G-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22042">
        <property type="entry name" value="EF-G_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14492">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00838">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00889">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="EF-G C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="5">
        <location>
            <begin position="1"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAG5106494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="633" mass="70413" checksum="93E103994355E15E" modified="2022-05-25" version="1">MLIRNLGSIKNMGEVHDGNTVTDYMEQERQRGITIVSAAVTFNWKDHRFNLIDTPGHIDFTMGVEQTLGVLDGAVVILDGSAGVEAQTRTVWKQADKYSIPRLVYVNKMDRADANFHMCLESLESKFEVTALPVQLPIKNDNGFVGILDLLTLEKIIFDKTSQGTKLLRQKLTEAEDSFLLERAREKRRLLVDKLSTIDDGLANFIIEQDSLDDIPTQVIADSLRSSTIKRKGIPVLLGSSYKNIGVQPLMDAIIFYLPSPDLHKKASLYRCFEDNLSARAFKIMHDKQRGPITFFRVYSGSLKKNQKVYNATREKYEQGSRLYAAYADDYEEIDEVTEGNIGGLAGCKFTITGDLLTSSPTVVSRAKNVAAKIKNLDEVEKDKFFSAGKIPDPVFFCSIEPPSLSAQVPLENALKELEREDPSLRVTLNEETGQTVLGGMGELHIDIIKERIKTEYKIDVDLGPLQIAYKETITQGIKDTLVSHHKIGTTNHDVNVTLSLIPNYEGKEILLFDKTKECASNIADIHPKVMAAVKKGVKMALNHGPKLGCPLIDVGVKVMGDLGKRRAQIQEVTVRGQYKVLRALVPLSELLGYSTTLRIITSGNGSFSSEFESYQSMGSVEEQQAIKQITGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HSI7</accession>
    <name>A0A8J2HSI7_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Similar to HSPBAP1: HSPB1-associated protein 1 (Homo sapiens)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HICCMSTLAB_LOCUS12498</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="3">May play a role in cellular stress response.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5106914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HSI7"/>
    <dbReference type="OrthoDB" id="438164at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.650">
        <property type="entry name" value="Cupin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041667">
        <property type="entry name" value="Cupin_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003347">
        <property type="entry name" value="JmjC_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12461:SF43">
        <property type="entry name" value="HSPB1-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12461">
        <property type="entry name" value="HYPOXIA-INDUCIBLE FACTOR 1 ALPHA INHIBITOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13621">
        <property type="entry name" value="Cupin_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00558">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51184">
        <property type="entry name" value="JMJC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="JmjC" evidence="4">
        <location>
            <begin position="85"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00037342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAG5106914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="389" mass="45249" checksum="6FC1D38163503BC0" modified="2022-05-25" version="1">MTPSRDLLKQIILEINEPILFNGIISNDNDNNWNKLELNNFIKLLGDNKLPFRVGKNKATIEPQWDINCPVQLMTINEFMEISDDNNNEDWYYFDYKYMHEWFNDKPEILEAVDWKLFGFEKSGRDSTLWIGSKGAHTNCHQDTYGCNLIAQLHGRKEWLLFPPDSGIQLKQTRIPYEESTIYSKYNFFSPTKNDREALERVNKAAKSVVLKQGQVLFVPKGWWHYVESLDFSVSVNVWLPLESDNEGRLREAVTKFLMSKMENVPASEDLKSVDLKNLSVLMQHCVDECKKLREKSDEIPKKKVKTTPLVLSDLVNEYPDIITAIDDLNKEQLSRIISLKNSRFKREDKINLEVNKSFNDDSDILKTVVDRFCSPDIIDVIVNSLLND</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HTA7</accession>
    <name>A0A8J2HTA7_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS12997</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5107957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HTA7"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035184082" evidence="2">
        <location>
            <begin position="21"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5107957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="84" mass="8738" checksum="3287D76E8DB771F8" modified="2022-05-25" version="1">MNKSIIILFIAFALLQLVRSDEEKPAADGPSNAAADAVKQGSEYIQSAVRQAKDAVQKGLGEVRGTLGSLNPLGGSKTEAPKEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HTK0</accession>
    <name>A0A8J2HTK0_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Similar to C1GALT1: Glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1 (Gallus gallus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HICCMSTLAB_LOCUS13179</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyltransferase 31 family. Beta3-Gal-T subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5108322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HTK0"/>
    <dbReference type="OrthoDB" id="414175at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016263">
        <property type="term" value="F:glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026050">
        <property type="entry name" value="C1GALT1/C1GALT1_chp1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23033">
        <property type="entry name" value="BETA1,3-GALACTOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23033:SF14">
        <property type="entry name" value="GLYCOPROTEIN-N-ACETYLGALACTOSAMINE 3-BETA-GALACTOSYLTRANSFERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG5108322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="452" mass="52920" checksum="3909AA71A421D11B" modified="2022-05-25" version="1">MYLRLLKRKLTFFLGFFIGFIITLYLASIFNNCNYKDCHGKSLKLKNKNTFVVNKKLTIRGVKSSDRDINLPEDDFIEDPQKIKYQKWLRGYNITLSKINLDHQYYGSLFESNYTSSSLESDWLKSKINIVCVVFVEKIKLAKAIYNTWSKNCNKVYFFSHKVTDSGSDPSIVKLSVKITSSWQLLCESLHHVWKSLNDSLQWVIVIKDDTMILLENLRYYVAPLDYNDGHYLGHPVVLWGQAYNVAQAGYVLSRGAVEKVISHFNTHEKCLAGGKYWKQEDYYLGKHLAALNIQPSDTRDHKLRDIFHGYPLQTLLWGLNKLGNYFTRAVYPSRGDCCSPRSVTFSVPDAERLYTINYYLYHLFVHNRGIYGNKPAPTPVPEQEVWKLALKDEFNITYFDNITNEVYYKIWRFKYVDPINLKLMTNKEYINGSDIFEALWSKQESERVKRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HUR0</accession>
    <name>A0A8J2HUR0_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Similar to sps1: Probable serine/threonine-protein kinase Sps1 (Caldanaerobacter subterraneus subsp. tengcongensis (Strain DSM 15242 / JCM 11007 / NBRC 100824 / MB4))</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HICCMSTLAB_LOCUS14107</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001893">
        <property type="protein sequence ID" value="CAG5110878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HUR0"/>
    <dbReference type="OrthoDB" id="7700243at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24345:SF0">
        <property type="entry name" value="CELL CYCLE SERINE_THREONINE-PROTEIN KINASE CDC5_MSD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24345">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE PLK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAG5110878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="75" mass="8582" checksum="2AB0AD68FD55600C" modified="2022-05-25" version="1" fragment="single">MEYFKSTTLSSYISKVSTTLDYGIKKNRNYFISSQICKALAYLHNLTPSILHKDIKPENILINEELVIKVCDLGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MEE8</accession>
    <name>A0A8J2MEE8_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Similar to MPP6: MAGUK p55 subfamily member 6 (Homo sapiens)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HICCMSTLAB_LOCUS4356</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MAGUK family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5085366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="43580at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030054">
        <property type="term" value="C:cell junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00071">
        <property type="entry name" value="GMPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06798">
        <property type="entry name" value="PDZ_MPP5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12036">
        <property type="entry name" value="SH3_MPP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.42.10:FF:000088">
        <property type="entry name" value="MAGUK p55 subfamily member 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000469">
        <property type="entry name" value="MAGUK p55 subfamily member 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008145">
        <property type="entry name" value="GK/Ca_channel_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008144">
        <property type="entry name" value="Guanylate_kin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020590">
        <property type="entry name" value="Guanylate_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004172">
        <property type="entry name" value="L27_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050716">
        <property type="entry name" value="MAGUK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035601">
        <property type="entry name" value="MPP5_SH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23122">
        <property type="entry name" value="MEMBRANE-ASSOCIATED GUANYLATE KINASE MAGUK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00625">
        <property type="entry name" value="Guanylate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07653">
        <property type="entry name" value="SH3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00072">
        <property type="entry name" value="GuKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00856">
        <property type="entry name" value="GUANYLATE_KINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50052">
        <property type="entry name" value="GUANYLATE_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51022">
        <property type="entry name" value="L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 4" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="L27" evidence="10">
        <location>
            <begin position="1072"/>
            <end position="1131"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="9">
        <location>
            <begin position="1164"/>
            <end position="1243"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="7">
        <location>
            <begin position="1259"/>
            <end position="1330"/>
        </location>
    </feature>
    <feature type="domain" description="Guanylate kinase-like" evidence="8">
        <location>
            <begin position="1330"/>
            <end position="1510"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="167"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="261"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="358"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="493"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="701"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="844"/>
            <end position="916"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="975"/>
            <end position="1000"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="1452"/>
            <end position="1515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="167"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="209"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="264"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="359"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="498"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="713"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="865"/>
            <end position="879"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="882"/>
            <end position="899"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="900"/>
            <end position="916"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAG5085366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="1525" mass="170056" checksum="56746038E0575567" modified="2022-05-25" version="1">MVDLSGYVIILINDNGKIKLYGSSADNAEYPEVSDEILEVNGRTLENATDTEVSQHIHQVIFILIFICIRSGTISLQVTRRAGHKMNHQRNSLFFDMDFKFIDEEDEELDGPNADKIRDAWVIALERGARERLQKLPALKKVKPRDIQAILHQQDDHYSNKEVLEKQRNYSDEPKLLHPSVTSKLGERRSSSPFQNGRTEVLIGEPEGGPRSPRGSTSSAINDFLSTDNPEPICRGLEALNGTPPPMSHPDTASLVLGSRRRSATSVNDIQLQNNNNSPSLRESKDSRSPHIPPDEMWVPGVTPGHHRELPVDVPDTLLQQAYANNKVILPLSPPPAPPLPKTTDSPVAVTVYPSTKLTTTTNNNNNNNNNNNNNNNQRPGNDLPLSDLRELTLNIKNDSSYHHKNLHHTPRNNLDAALPVNDLSGFTHLIEITVDKNSDNSSNDSTTKSPILSIFDEIDSPTSNHSHLQIKESNVDIDDDYPFAKEDYPTMLKTCSDDSASPRSSSGRSDSTTALDTSLIIPGKESPLYDARRIDLGSPCRTIPDLSIYGMTRETTSFDNPAYGLDLHQGLLIRSDEVLDLRIIGDNCKNCEIIPIGKPEKSLGKKKKPKNTSSFDVDLIAAKSTDDLLAADLTGFVARTSIKKPPKKSNLPVLPTPPPLPPQVPTINGYSTLRNDSHKSSSRGFREVAVDCPPDFIPVTKSHPIYPPPNKLEAKNKNSDSKVLTDRSKSKESVVALDDNDGQKVRLKSLKHPGKLLTPRPISVLSNTIPNISPNKIMKNRKTLPMSYRLSDDDKAANFALMIDDDNSCVGLSFSRLYSFRNESFDNKTNSIKSMVNNNDDVLGTDRDFDQSKGNGVKPLLPPRDQKRAPARPPKDNLRLSTRNSTINDNNDNTSSNTGIESSIVSQPTPQQLQTIQKYKEQLRQRKDFEERREFLNQSLRGSQKLHALESHAKQLAGQENPAYSQDEVTNTTGNVRKEKEQTSGQASPKVAADELPAEDPKILSTLERLQLQLRNLSGALGISGPGVEAELEAVRSLVQQRRFATALATHNFIKTKLHTGKLHKAYNDDASNLARDCVELFEECQTTQTVKSPETLAIIEELTGLLTSYDMEGLLFAHDSIISYCDGIQLKDGPLSSSASEQSLSRHSSLRDSLRNTDNIKIIKIEKTNEPLGATVRNEGDAVIIGRVVRGGAADKSGLFNEGDEVLEVNGVEMRGKSVNEVCDILASMQGSLTFIVLPASAVVRSNSDSSRLEDNNLIHHVRAHFDYDPEEDPYIPCRELGISFQKGDVLHVISQDDSNWWQAYREGEEDQTLAGLIPSQAFQHHHKRPIVLIGPPNIGRHELRQRLMQDSERFAAAIPHTSRPRKGSEVDGQDYHFITRQQFETDIVGRKFVEHGEYEKAYYGTSIEAIRSVVNSGKICVLNLHPQSLKILRNSDLKPYVVFVAPPSLEKLRQKRIKNNENYKEDELKDIIEKARDMEDKYGHLFDMIIINNDTDRAYNQLLTEINSLEREPQWVPATWVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MEL1</accession>
    <name>A0A8J2MEL1_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein CNPPD1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HICCMSTLAB_LOCUS4490</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CNPPD1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5087346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MEL1"/>
    <dbReference type="OrthoDB" id="244495at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000307">
        <property type="term" value="C:cyclin-dependent protein kinase holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20557">
        <property type="entry name" value="CYCLIN_ScPCL1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013922">
        <property type="entry name" value="Cyclin_PHO80-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615:SF108">
        <property type="entry name" value="PROTEIN CNPPD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08613">
        <property type="entry name" value="Cyclin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="222"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00040808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG5087346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="364" mass="41784" checksum="9AA9CDC2D4E8F86C" modified="2022-05-25" version="1">MSNTSRGKRLSRKLKTMGDHNLFLNRITKSLYYSKLPMTDRLSLPVTEFAAELFSEVKSGCSLERLDVEEASRISRNACVSPCSFVLALLYLERLKDCNPEYLYKAAPAELFLVSLMVASKFLNDDGEDDEVFNVEWAKSGDLTLAQMNRLEMEFLDAINWSIYVNDKEFWNRLRKLEELMAYKEAKKRGWFSYTEIICLMDTIRITAIINTIFNISTVCVATYAIGLITLFGSALITSHIPGTYLALRQSSKPATLNESELIVPETELIEETELPDDFLKCNVSCNNCIVKTPTSTSPDKIGWVSTIINWFSKTQLKFENDKLKNPEAFITNSQSLLRDHILWENIIVEINWKDTLRVYFEYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MER2</accession>
    <name>A0A8J2MER2_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein hunchback</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">HICCMSTLAB_LOCUS4520</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Gap class segmentation protein that controls development of head structures.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the hunchback C2H2-type zinc-finger protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5087465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MER2"/>
    <dbReference type="OrthoDB" id="6077919at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035282">
        <property type="term" value="P:segmentation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000646">
        <property type="entry name" value="Myeloid zinc finger 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000123">
        <property type="entry name" value="transcriptional repressor CTCF isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000045">
        <property type="entry name" value="ZFP69 zinc finger protein B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000100">
        <property type="entry name" value="Zinc finger 45-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000744">
        <property type="entry name" value="zinc finger E-box-binding homeobox 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000710">
        <property type="entry name" value="Zinc finger protein 768"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050331">
        <property type="entry name" value="Zinc_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515:SF49">
        <property type="entry name" value="GASTRULA ZINC FINGER PROTEIN XLCGF49.1-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515">
        <property type="entry name" value="PR DOMAIN ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0302">Gap protein</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="12" id="KW-0804">Transcription</keyword>
    <keyword evidence="10" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="8 14" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="184"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="212"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="240"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="268"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="296"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="324"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="352"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="380"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="96"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="148"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="402"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="103"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="158"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="407"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CAG5087465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="695" mass="79448" checksum="DBD9C8E45082D8DE" modified="2022-05-25" version="1">MMNEGCPNCGQLTNASCSRLIEDTCGHKKCRICLLYEEQGCKTCEKERLIPAIIDCQYDDKVPKSPSIILDISDAKSTIIIKRHHDKHYPDTICAPLNPPIPHEQHEERRENLSEEINPSQRLDNLEGLASSLKQDYVPDPLPLDNLNTNLSKISNSKPEEDKVKQRRPDRSHIIVLSADPEMYKCSICNKIFRNKKGKCYHDGCITGIRPYKCGICERSFVKKSHFEYHERVHSGYKPFKCSLCDKAFPQKNKLNRHMLSHSSKKQFVCTKCDKRYSKKDDLKSHMMVHSGTLPYSCESCGKSFRLRNNLNRHAFIHSNERPYACDYCGKSFKDKSLLSRHKRTHSKERPYSCAHCSRVFLSKSELTRHLTIHTDVKPFNCNICQTVFRRKDNLNRHVRHHHSEDSNNFNNSGVGTSQKIDKTKDKVKKKFVRKEKGKGKISLKNKDIEERNEIMTNIRSVHNIISRCDARGNVYPVIRATSELSNAVSVINGPISRLSPEDKGRFGNEKKKVLTYTEPISPAEAIVINQRIEEKLYNINQGPGTCYYRDCNSSRINDASRAGLGLSGRGLPPLPPMRHNSPIRAVPRYQRRADSYFSPPKSTNLIELKSPKSDCAVAKGNSECEAACNSNGGVAAERNSNSNDRKGVFEERANCVPTIQKNVGLEHEKETREFETHWRRRTLESLKPRINLNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MGT8</accession>
    <name>A0A8J2MGT8_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Similar to Venom metalloproteinase 3 (Eulophus pennicornis)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HICCMSTLAB_LOCUS2911</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001117">
        <property type="protein sequence ID" value="CAG5079060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MGT8"/>
    <dbReference type="OrthoDB" id="7695528at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006509">
        <property type="term" value="P:membrane protein ectodomain proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001590">
        <property type="entry name" value="Peptidase_M12B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11905">
        <property type="entry name" value="ADAM A DISINTEGRIN AND METALLOPROTEASE DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11905:SF249">
        <property type="entry name" value="SOL NARAE, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01421">
        <property type="entry name" value="Reprolysin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50215">
        <property type="entry name" value="ADAM_MEPRO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035281014" evidence="2">
        <location>
            <begin position="22"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M12B" evidence="3">
        <location>
            <begin position="580"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="744"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="743"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="747"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="753"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="759"/>
            <end position="783"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG5079060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="805" mass="92197" checksum="303CC97BF9B6AEAC" modified="2022-05-25" version="1">MFGLKVIFIWLLVSKLSFVYPAQIKFNSLECDGERVKGADCEKGEVRFSSQHKRSTTDGFPVSFVAFGKEINLFLTERKGAFFSSTTPVYRLFRAADVTYRVDGNNDMNKFANTKIFEEVSHSASVTIEILPDGNGKVYGGFIGSENVLFVWNLQNQSYQFYKFKDERTTEEYFLNENYLMPHTHSSPDYLSYPYNYYQRLQQESRTPEIIYPKVLVVVDYQLLIDVGEDKILMYVLHRWNLIDMVYRGFRSPQFKFNIAGIVIPTGPDSLKYLSDSSFYVNDMLNVDVDISLKFFKKWLFHHNHITPINSYDLAITMILKKTVPEYNSERGPISVNGEAFKGAACVTDYYRQEVLKAGVVADAGVYTSIITAAHEVGHFFCNWQVQSEFLIEIPESGLSNIQYEMGVINFPRRHARSLGNENINLQLNAYGETINLNLQKRSSSLYGASTRIYKLSKDNLQSLTMAQDEKPVAFQRTIYEDLDHFASLTVDTFSDGSRTIRVKFSANIGTANLTILPASLQHVQQPSSMLNFGNGLSNQYIYYRSNNLMTGYNDAVIPWNMVPAAPQQNNRVVEVPDTLYLEVLIIVDYPLLNKIGQANIINYLLTFWNQVDILYRALNRPLYKINIAGIVLPKDGEVLEYFYKDPIYGWISRSLEFKDFLSNNAKWLYKNQEIFPLDSYDLAITMTSREQRTKWTSSGYRSSAGISYIGQVCQVNHYYRTRENNAIVFDDGYFAGVPVAAHEIGHLLGAQHDNRYPCSDRDGFIMASVLSKSSNRFKWSPCSISDFKSFLSTDPKCLYNKPNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MHS4</accession>
    <name>A0A8J2MHS4_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Olfactory receptor 88</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HICCMSTLAB_LOCUS3415</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5081931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MHS4"/>
    <dbReference type="OrthoDB" id="6617147at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005549">
        <property type="term" value="F:odorant binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004984">
        <property type="term" value="F:olfactory receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004117">
        <property type="entry name" value="7tm6_olfct_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21137">
        <property type="entry name" value="ODORANT RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21137:SF35">
        <property type="entry name" value="ODORANT RECEPTOR 19A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02949">
        <property type="entry name" value="7tm_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0552">Olfaction</keyword>
    <keyword evidence="8 11" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="9" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="123"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="188"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="253"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="289"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAG5081931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="387" mass="44499" checksum="C6A00AC4C6CD92C9" modified="2022-05-25" version="1" fragment="single">DQRDLDEGIKMFYWGEKVSRGIGAWPLAPNNNLFTVFFIYLTVVGSLEYVSLFKEYIDFTSAIDMITEILAFQHIYVSVLMLRVHTDKLRYLITESLKDYQMSAFKNSLEIKIFIAYINKGRAFAKFVITFIATTAISWFFMPLTALAAPVSDNETMQFVVPYRFYIFYKVNDYTTYLLTYISQGPPFFIISTGHITSEGFLIVFAFHLCGRLAILVERINGLKNEPNISKIKLSKIISEHARLLKMGENIRGAFATALLAYLLNGMILLCLIGYQILVNIMTGPNSDLMLHFTFIFATYFIITTFCIVSEQLIEESNSVCEAFWNTEWYNMPRECIYDIIYCINRSQKPLALQAGKFSYFDSTTLTEVTKTSMGYLSVLRNFLTVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MJJ1</accession>
    <name>A0A8J2MJJ1_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transcription initiation factor TFIID subunit 8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HICCMSTLAB_LOCUS4583</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TAF8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5087702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MJJ1"/>
    <dbReference type="OrthoDB" id="2193813at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22918">
        <property type="entry name" value="HFD_TAF8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08049">
        <property type="entry name" value="TAF8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006565">
        <property type="entry name" value="BTP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037818">
        <property type="entry name" value="TAF8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019473">
        <property type="entry name" value="TFIID_su8_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46469">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46469:SF1">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07524">
        <property type="entry name" value="Bromo_TP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10406">
        <property type="entry name" value="TAF8_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00576">
        <property type="entry name" value="BTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035259321" description="Transcription initiation factor TFIID subunit 8" evidence="8">
        <location>
            <begin position="26"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="domain" description="Bromodomain associated" evidence="9">
        <location>
            <begin position="69"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="266"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="286"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAG5087702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="346" mass="40297" checksum="6F084B2593888DDE" modified="2022-05-25" version="1" fragment="single">MLVWNYLYFSTLYLVYIYSSCKVTCDNKTFCIYNFTFQWLQIKNYILLHLYYKLSGNKFKKKMESQQTTNSRRKLLNYVISGILSENEFITCEKQVMETLTEMLQSFLVQIGESSRNFSELAGRTEPLIADIILALINMGFKLDGLTKYAMRQNRTTLPPLQPQTQSKQMNMLPAGEKQPHPPHVPSYLPQFPDPHAYIRTPTHKQPVTEYEAIREKAASQKRDTERALTRFVAKTSETHIIACKPQFPPYLSALMPQDQVFEPETEFDFERTAPVKKRKETKTNDDDDDDDDVKEDIAVKSEPTETSEEVSTQQEIDNPYLRPGKIPHNKVAMFQRIQFPQTLVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MKY7</accession>
    <name>A0A8J2MKY7_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Similar to Mmab: Corrinoid adenosyltransferase (Mus musculus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HICCMSTLAB_LOCUS5792</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the Cob(I)alamin adenosyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5090908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MKY7"/>
    <dbReference type="OrthoDB" id="549173at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008817">
        <property type="term" value="F:corrinoid adenosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1200.10">
        <property type="entry name" value="Cobalamin adenosyltransferase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016030">
        <property type="entry name" value="CblAdoTrfase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036451">
        <property type="entry name" value="CblAdoTrfase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029499">
        <property type="entry name" value="PduO-typ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12213">
        <property type="entry name" value="CORRINOID ADENOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12213:SF0">
        <property type="entry name" value="CORRINOID ADENOSYLTRANSFERASE MMAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01923">
        <property type="entry name" value="Cob_adeno_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89028">
        <property type="entry name" value="Cobalamin adenosyltransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Cobalamin adenosyltransferase-like" evidence="5">
        <location>
            <begin position="46"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU366026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAG5090908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="199" mass="23144" checksum="47A56AE20E4A7135" modified="2022-05-25" version="1">MELVKHSWRKYLLVYNSHLSPLVRQRVESKIIQKAFLSSSSEKKSDKLTDDDVIFNAIGATDELSSYIGLAREFACETTVQHPYVDKLKRVQMILFDINNAITRIQKSSKINSFKTKHTQDLEEWITEYANQLPPPEDYIIPRAERSITPLVYNGFLDKETQNYLHRLSEFLFTVSRIAAKCDQRTESIYIPPAEVQEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2ML29</accession>
    <name>A0A8J2ML29_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Similar to cut-1: Cuticlin-1 (Caenorhabditis elegans)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HICCMSTLAB_LOCUS5943</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5092139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2ML29"/>
    <dbReference type="OrthoDB" id="6139674at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042302">
        <property type="term" value="F:structural constituent of cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.4100">
        <property type="entry name" value="Zona pellucida, ZP-C domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.3210">
        <property type="entry name" value="Zona pellucida, ZP-N domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056953">
        <property type="entry name" value="CUT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051962">
        <property type="entry name" value="Cuticlin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042235">
        <property type="entry name" value="ZP-C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001507">
        <property type="entry name" value="ZP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22907">
        <property type="entry name" value="GH04558P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22907:SF54">
        <property type="entry name" value="GH04558P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25057">
        <property type="entry name" value="CUT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00241">
        <property type="entry name" value="ZP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51034">
        <property type="entry name" value="ZP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0193">Cuticle</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="329"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="domain" description="ZP" evidence="4">
        <location>
            <begin position="42"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAG5092139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="381" mass="41884" checksum="684A139B329566C5" modified="2022-05-25" version="1">MIINPQERNVKLDTLAVFRVALIARRLSSNATVAVASTVRIECASESIIVHISTEGNTDFHGLVYPRGLSKNSSCLQEYKSQPAPITYRLPLRSCNTMPTELDDGGIEYFNTIVVQPHLKLVTNQGRGFHVRCRYQTRDKVVTNDQTRVAMLQSLPLQAMAPMPGCTMKIFSGDPTRHHVAENVKIGDPLTLVISIDKQEICPIDGEIMGQFTYSEDKTEAKVNFQAHKFPYTASVYYQCNVRLCTKHGGGCSDTPPSCNEISRRKRATGRLDDKDVALDGTPATIEVYSGLYVNEASDLGGKSELTDDVFRERTIDEADSICISQRSFAIGIAIAGLILMIAVVAAILVLLAKRRHKNISTTGSSIYSGPYTNTAYSHSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MLK4</accession>
    <name>A0A8J2MLK4_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">COMM domain-containing protein 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HICCMSTLAB_LOCUS6454</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the COMM domain-containing protein 3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5092935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MLK4"/>
    <dbReference type="OrthoDB" id="1917519at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006814">
        <property type="term" value="P:sodium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017920">
        <property type="entry name" value="COMM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037355">
        <property type="entry name" value="COMMD3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31159">
        <property type="entry name" value="COMM DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31159:SF1">
        <property type="entry name" value="COMM DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07258">
        <property type="entry name" value="COMM_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51269">
        <property type="entry name" value="COMM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="COMM" evidence="3">
        <location>
            <begin position="112"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00016548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00093469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG5092935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="189" mass="21867" checksum="750F2CD63611A1AF" modified="2022-05-25" version="1">MELPDTLKNNLRIIKTSLSDELFDKLLSDCNNMLMNVIIDNPKDKMTIYSDYISIIKEAARNNYDPENLSDYLQTTGIFNDTQIQKLCQVYYKQIKTPMVLHLSSIGDSHPCIVDISWRLDYCLKTSNNSYMNNCIYHIKLTTKRGGTISDVDFTCTIEGLHELVYKIKDIVRHMEKLVQRNCGDKALK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MLQ8</accession>
    <name>A0A8J2MLQ8_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS6623</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5093147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MLQ8"/>
    <dbReference type="OrthoDB" id="7989680at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071897">
        <property type="term" value="P:DNA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052560">
        <property type="entry name" value="RdDP_mobile_element"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36688">
        <property type="entry name" value="ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36688:SF1">
        <property type="entry name" value="ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="2">
        <location>
            <begin position="27"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="520"/>
            <end position="624"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5093147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="661" mass="76233" checksum="A2B665F4F4D7C4D5" modified="2022-05-25" version="1">MAHTTQQQNIEQELTGSNSIIRFSAINVNSLEANKRKLDMEEFVKNNQIDIALISETKLHSEHKLSFNDYNLIRTDRPNAKNGGGTAILINKKLSFTPISYPNSLSNKVIEYTAIRLKVNSKKSLIIFSIYAACNSNRSLIAELDKIYHDFRLDKPDIYFIMAGDWNARHTKWGDSKINDYGAMLNRWEVKNSITHKCTLYNPNRPTYPSAGSYLDHCLPDTRIEIKELSSNGLLKTLPYDSHHNAIYFTIDTNKTFMGLASSPPPTIRYNYKRTNWRKFAEDLLYNHKNQIPSDKNLTISEIDSHILNLEKEITTTIIKIVPKVEADTKKGCLKYVNNTIKKLQAMKSKLISEKFRATNQEEKYRLNQLIKEINKKLTKEFQKSETAYWTAKTKSINYRDSAKFFPRINRFFRYREPPRVDNLTISKDSPLLTDEIINDPETSKIDGKHLITHSTAKLNIIGKYFESINSPRYSNIGTMTKTIADNAANDIKKHNLTHTTFNRSNRAYYPVQNENEPKFLHSYIEVEILLKKTKNKTSSGTQQGTVTSPILFIIYCRNVLNLFLMNSGNNTHYGAYADDTAIYVAHTKIPVIEKRLTSLVNQIYEYLEQWNLKMNAFKSETILFRKTVNEITPPTVLLIKTFQIKITDKDTGLETIIPNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MLS4</accession>
    <name>A0A8J2MLS4_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Histone H2A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">HICCMSTLAB_LOCUS6451</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5 12">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 12">Belongs to the histone H2A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5092932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MLS4"/>
    <dbReference type="OrthoDB" id="9421954at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00074">
        <property type="entry name" value="HFD_H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000020">
        <property type="entry name" value="Histone H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002119">
        <property type="entry name" value="Histone_H2A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032454">
        <property type="entry name" value="Histone_H2A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032458">
        <property type="entry name" value="Histone_H2A_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23430">
        <property type="entry name" value="HISTONE H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16211">
        <property type="entry name" value="Histone_H2A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00620">
        <property type="entry name" value="HISTONEH2A"/>
    </dbReference>
    <dbReference type="SMART" id="SM00414">
        <property type="entry name" value="H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00046">
        <property type="entry name" value="HISTONE_H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0007">Acetylation</keyword>
    <keyword evidence="6 12" id="KW-0158">Chromosome</keyword>
    <keyword evidence="9 12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="11 12" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="10 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="14">
        <location>
            <begin position="11"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="Histone H2A C-terminal" evidence="15">
        <location>
            <begin position="91"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF16211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CAG5092932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="140" mass="15193" checksum="FC07756D7A8A25BC" modified="2022-05-25" version="1">MSGRGKGGKVKGKSKTRSSRAGLQFPVGRIHRVLRKGNYAERVGAGAPVYLAAVMEYLAAEVLELAGNAARDNKKSRIIPRHLQLAIRNDEELNKLLSGVTIAQGEVLRAFVNVIIDFIYVKSGFDAVIPLIKLSIANHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MMR1</accession>
    <name>A0A8J2MMR1_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Similar to ZCCHC9: Zinc finger CCHC domain-containing protein 9 (Homo sapiens)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HICCMSTLAB_LOCUS7670</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5095360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MMR1"/>
    <dbReference type="OrthoDB" id="3863715at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.60.10:FF:000091">
        <property type="entry name" value="Zinc finger CCHC-type-containing 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042246">
        <property type="entry name" value="ZCCHC9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46242:SF1">
        <property type="entry name" value="ZINC FINGER CCHC DOMAIN-CONTAINING PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46242">
        <property type="entry name" value="ZINC FINGER CCHC DOMAIN-CONTAINING PROTEIN 9 ZCCHC9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="7">
        <location>
            <begin position="411"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="7">
        <location>
            <begin position="463"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="70"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="34"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="99"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="112"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="177"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="239"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="258"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="293"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG5095360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="550" mass="62763" checksum="E2FAB4642C6907A4" modified="2022-05-25" version="1">MTRFARAKGSKASNERLPCEATPWHVMKQQLDTVKAKESSEKPKNAKELLKEKDDPYYWDTVVNKTEWATLDTDKPSKSVKKNNPGKVEKNSPKKSALKKASLDNSVSLNDSNDKSRKRKPEEVEKTAGETENVPKKKKKNKLANNGEENVVENFPKKKKNKIVNNGEENVSKKKKNEIVNNREENVVENVPKKKKNKLTNNKEENVSKKKKNKPTANSEENSIVDENKEEKKLNNVKLSKRQKRNRKNKIKNDNSNQQDEVSTPITFNVEGNDWNSSIKFGSSDGKSKFKPKNNNNDNSKPENNNYPNNYNDKRFNQRVVKQRPAKIRDNLEHKRRKPEPGAQKVIINGMEVEIVLHDGFPVRKDDAERLKELRKKLVMNGIPKPEIDRAMKLERRKAEKALARIRKNVCFHCRKAGHNLSDCPELGREEAATGICFKCGSTEHTHFECKVNKKEEFRFATCFICREQGHIAKQCPDNPNGLYPKGGACSSCGDVTHLKKDCPALIEQKEGARITLGTIADVDSLETIDELDKSKKNEVVKESKKIVKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MMX3</accession>
    <name>A0A8J2MMX3_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Mitochondrial (Danio rerio)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HICCMSTLAB_LOCUS9119</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5099558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MMX3"/>
    <dbReference type="OrthoDB" id="188276at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002098">
        <property type="term" value="P:tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04164">
        <property type="entry name" value="trmE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14858">
        <property type="entry name" value="TrmE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1360.120:FF:000007">
        <property type="entry name" value="tRNA modification GTPase GTPBP3, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.120">
        <property type="entry name" value="Probable tRNA modification gtpase trme, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.430">
        <property type="entry name" value="tRNA modification GTPase MnmE domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00379">
        <property type="entry name" value="GTPase_MnmE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031168">
        <property type="entry name" value="G_TrmE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018948">
        <property type="entry name" value="GTP-bd_TrmE_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004520">
        <property type="entry name" value="GTPase_MnmE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027368">
        <property type="entry name" value="MnmE_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025867">
        <property type="entry name" value="MnmE_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027266">
        <property type="entry name" value="TrmE/GcvT-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00450">
        <property type="entry name" value="mnmE_trmE_thdF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003661">
        <property type="entry name" value="PRK05291.1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42714">
        <property type="entry name" value="TRNA MODIFICATION GTPASE GTPBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42714:SF2">
        <property type="entry name" value="TRNA MODIFICATION GTPASE GTPBP3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12631">
        <property type="entry name" value="MnmE_helical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10396">
        <property type="entry name" value="TrmE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116878">
        <property type="entry name" value="TrmE connector domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="GTP-binding protein TrmE N-terminal" evidence="8">
        <location>
            <begin position="42"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="MnmE helical" evidence="9">
        <location>
            <begin position="160"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="domain" description="G" evidence="7">
        <location>
            <begin position="257"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF10396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF12631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAG5099558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="508" mass="56276" checksum="56832E4400732BAD" modified="2022-05-25" version="1">MLMRVVTKCWRSVVLKRLNDTGGGGIFSFVCRDSSTGASISTIYALSSGHGKCGVAVVRVSGNKSLEALNKMTNLSNPSPRQAFLRKIYDPLTGDIIDKGLCLWFPGPNSFTGEDSVEFQVHGGPAVIESLMSALSKLKLKPAEPGEFTKRAFYNGKLDLTEIEGLADLIHAETEQQRKQALLQADGSLSKLYNSWKKKLSTSLANIEAYIDFGEDDNIEQGVLEKCNDTTRALVAEISQHLADGRRGEILRTGVRTVIIGQPNVGKSSLLNYLACRNAAIVTPIAGTTRDIVELSTNISGYPVILADTAGLVTSTEDIVEKEGIKRARSYATTADFIILMIDVSNFLSSGKSFQDYLHYYVDQLEIRDLIKEKRGNFIIIVNKIDLVKYDDYNIVNDLREYGAIPISCDKEDGFSDLLHALTIKFKDLCGNPSRENPTISQTRHRVHLKTCVNYLNNYLGIVNNYEYDMVIAAQQIRFAMRELGKITGHVSSEEILDIIFKNFCIGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MN38</accession>
    <name>A0A8J2MN38_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Peptidoglycan-recognition protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HICCMSTLAB_LOCUS9377</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the N-acetylmuramoyl-L-alanine amidase 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5100086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MN38"/>
    <dbReference type="OrthoDB" id="10001926at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008745">
        <property type="term" value="F:N-acetylmuramoyl-L-alanine amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042834">
        <property type="term" value="F:peptidoglycan binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045087">
        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009253">
        <property type="term" value="P:peptidoglycan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06583">
        <property type="entry name" value="PGRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.80.10:FF:000001">
        <property type="entry name" value="Peptidoglycan recognition protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.80.10">
        <property type="entry name" value="Peptidoglycan recognition protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036505">
        <property type="entry name" value="Amidase/PGRP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002502">
        <property type="entry name" value="Amidase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017331">
        <property type="entry name" value="Peptidoglycan_recognition"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015510">
        <property type="entry name" value="PGRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006619">
        <property type="entry name" value="PGRP_domain_met/bac"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11022">
        <property type="entry name" value="PEPTIDOGLYCAN RECOGNITION PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11022:SF75">
        <property type="entry name" value="PEPTIDOGLYCAN-RECOGNITION PROTEIN SB1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01510">
        <property type="entry name" value="Amidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037945">
        <property type="entry name" value="PGRPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00644">
        <property type="entry name" value="Ami_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00701">
        <property type="entry name" value="PGRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55846">
        <property type="entry name" value="N-acetylmuramoyl-L-alanine amidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 6" id="KW-0391">Immunity</keyword>
    <keyword evidence="2 6" id="KW-0399">Innate immunity</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035248899" description="Peptidoglycan-recognition protein" evidence="8">
        <location>
            <begin position="19"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidoglycan recognition protein family" evidence="10">
        <location>
            <begin position="22"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="N-acetylmuramoyl-L-alanine amidase" evidence="9">
        <location>
            <begin position="32"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="61"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR037945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR037945-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAG5100086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="192" mass="21047" checksum="528C0F7CC89FBD2B" modified="2022-05-25" version="1">MFLITEIIFINALVLISGQSTVNIISRQEWGARLPKLLPVNLTVNPPALVVVHHSSGGTGCNTQAICQAKVRNFQNFHMDVKEWDDIGYNFLIGEDGNVYEGRGSGIKGAHFPAYNARSLGICFIGTFDKKIPAPAALKTAKAFLSHAVTLGKLQSNYALIGHRQGRATTCPGDKLFELIQTWPQWKNLTTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MNK7</accession>
    <name>A0A8J2MNK7_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS7256</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5093930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MNK7"/>
    <dbReference type="OrthoDB" id="6270329at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="126"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="138"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="188"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5093930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="232" mass="24488" checksum="B590CAF78D6AEEE8" modified="2022-05-25" version="1">MDNSSYLPNHLPPPSLVVFSQAGGLPDGLRMQRPFNPQVTDSKELQVPFSTAAQLGYGLHHMLHLPHQFLHPLDPRFRTFPPLGPSAFAPPSKCLKVETGGSSVSSGLASIGSLSNMSNMFSPSLPSSGVAGGLPGGPSNQEVAPQSPAGSASRSPLGTGPGSTNASNRGPSPDDDDRDTNATPGSENTERSTPEEGRPYRPMKIVIVKRVNYKYTLVSRGAVSRTDRFVDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MP41</accession>
    <name>A0A8J2MP41_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Innexin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">inx</name>
        <name evidence="13" type="ORF">HICCMSTLAB_LOCUS7606</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Structural component of the gap junctions.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell junction</location>
            <location evidence="1">Gap junction</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 12">Cell membrane</location>
            <topology evidence="2 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the pannexin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5095231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MP41"/>
    <dbReference type="OrthoDB" id="5867527at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005921">
        <property type="term" value="C:gap junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005243">
        <property type="term" value="F:gap junction channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034220">
        <property type="term" value="P:monoatomic ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007602">
        <property type="term" value="P:phototransduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000990">
        <property type="entry name" value="Innexin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11893">
        <property type="entry name" value="INNEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11893:SF41">
        <property type="entry name" value="INNEXIN INX2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00876">
        <property type="entry name" value="Innexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01262">
        <property type="entry name" value="INNEXIN"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51013">
        <property type="entry name" value="PANNEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0965">Cell junction</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0303">Gap junction</keyword>
    <keyword evidence="11 12" id="KW-0407">Ion channel</keyword>
    <keyword evidence="9 12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="107"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="175"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="266"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004610"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU010713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAG5095231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="358" mass="41951" checksum="25832ACC2C61495E" modified="2022-05-25" version="1">MFDVFGSVRGLLKLDQVNIDNNVFRLHYKGTVILLIAFSLLVTSRQYIGDPIDCIVDEIPLNVMDTYCWIYSTFTVPDRFGIIGRDVVQQGVASHVEGTDKVKYHKYYQWVCFALFFQAILFYVPRYLWKTWENGRLKMLVLDLNCPIVTDSSKTERSKLLVDYFRTNLHTQNLYAYRFFFCEILNFINVVGQIYFMDYFLDGEFSTYGRDVVRFTEMEPEEREDPMARVFPKVTKCTFHKYGASGTVQKFDGLCVLPLNIVNEKIYVFLWFWFIILSVISGLSLLYRLAVVLLPKLRLMILRARSRISSQSEIQTISNRFQIGDWFVLYQLGKNIDPLVFKQLITDLATRFEGKESV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MRL4</accession>
    <name>A0A8J2MRL4_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Chitinase GH18 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HICCMSTLAB_LOCUS11752</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 18 family. IDGF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5103923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MRL4"/>
    <dbReference type="OrthoDB" id="76388at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004568">
        <property type="term" value="F:chitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000071">
        <property type="entry name" value="Imaginal disc growth factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011583">
        <property type="entry name" value="Chitinase_II/V-like_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029070">
        <property type="entry name" value="Chitinase_insertion_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050314">
        <property type="entry name" value="Glycosyl_Hydrlase_18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177">
        <property type="entry name" value="CHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177:SF235">
        <property type="entry name" value="CHITINASE-LIKE PROTEIN IDGF1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00636">
        <property type="entry name" value="Glyco_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54556">
        <property type="entry name" value="Chitinase insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035297103" evidence="7">
        <location>
            <begin position="19"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="domain" description="GH18" evidence="8">
        <location>
            <begin position="25"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAG5103923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="433" mass="48007" checksum="94BA66AB11E6AE4A" modified="2022-05-25" version="1">MKLLLAVIAALTVSLGAALDPHEHNKVVCYWNSTSFERPGPGKFQIDDLKPAIPYCTHLVYGFAGIDPNSFEAIPLHPNLDTGAGYSFYRIVNQLRQTYPHLKVYLSVGGNADPDYDTHKYLTVTETPEARNKFINSAVRLVTEYDFDGIDLAWEFPETKVKKHRSTFGNVWHNIKKAFGGGKFKDEHEEEHRNGFTNLVRDLKVQLRSKNKALTLTVLPHVNASSKFDARLLAPNIEAVHLMAFDQITPERNPKEADYPAPIYESYNRVPQDNIDASVRYWLEHGTPGGKIVIGIPAFARTWKLTSESQISGVPPIVADGPGAEGPHTATPGLLSYGEVCTRLTESHVGRLRRVSDPSKKYGSYAYQSYNPETSADGIWVGYEDRDTAGNKASYSKAKGLGGVAIWDLSTDDFRGICAGDKFPIVHAAKDKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MRM3</accession>
    <name>A0A8J2MRM3_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cyclin-dependent kinase inhibitor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS11797</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5104027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MRM3"/>
    <dbReference type="OrthoDB" id="6818750at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.365.10">
        <property type="entry name" value="p27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044898">
        <property type="entry name" value="CDI_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5104027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="108" mass="12732" checksum="4A91CE7C6006D52D" modified="2022-05-25" version="1">MLAAPFCRELHFGNMLTSRMQSHVPRCLFGSPNPKDSVELLQESLDMERSKFERRWGIDPCQEDKENVQRKFERSPRKNRSSPYSRQTCIHVDPNQVIKKQEPQKTTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MRY1</accession>
    <name>A0A8J2MRY1_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Similar to Toll-7: Toll-like receptor 7 (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HICCMSTLAB_LOCUS12131</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5106179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MRY1"/>
    <dbReference type="OrthoDB" id="676979at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050328">
        <property type="entry name" value="Dev_Immune_Receptor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24373:SF370">
        <property type="entry name" value="FISH-LIPS, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24373">
        <property type="entry name" value="SLIT RELATED LEUCINE-RICH REPEAT NEURONAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00364">
        <property type="entry name" value="LRR_BAC"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="5" id="KW-0675">Receptor</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035271081" evidence="4">
        <location>
            <begin position="20"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAG5106179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="450" mass="50865" checksum="49DC3083A6018E39" modified="2022-05-25" version="1">MRSLLIFSLWCLFVQDSIGGDSLDFSGMGIATLRKPFISDEHLTDLNLSHNHIWNVSSDVFEDLPSLVYLNLSHNFFPFSQLKFKNTSVLETLVLDEAVVGDLDFDVTYFEEETLEDEYNRLRETKAKHNYGFDITFTQDWTLPKLKHLYLRGHNIEHIKFAGVDALDLLMPEISHLYLSNNKLITFDLEKTLPMSLQELYLDDNKLTNFDADNLNNVAVLALDGNKMSNFCDINEPCKGITLKHSYSLEVLSVSRMGLENIVPDAFKFLVNLIKLDLSDNGINSFPSNALSDLLSIKILFIDNNVLEAVPEIKNLNHLEKLSLSKNLISELTENSFSGDLKQLKSLNLSSNIITSISSGAFDKLGSLEELDLSKNLLYTLPNDWIPDNVNLQYLQLKENFFQNFSSLALGRAKNLKYVSIGGNRFSAMDVGLLAELPKTAIIDFENTLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MSC7</accession>
    <name>A0A8J2MSC7_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to llph: Protein LLP homolog (Danio rerio)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS9057</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the learning-associated protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5099425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MSC7"/>
    <dbReference type="OrthoDB" id="6257894at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001099">
        <property type="term" value="F:basal RNA polymerase II transcription machinery binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097484">
        <property type="term" value="P:dendrite extension"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018784">
        <property type="entry name" value="LLPH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34253">
        <property type="entry name" value="PROTEIN LLP HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34253:SF1">
        <property type="entry name" value="PROTEIN LLP HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10169">
        <property type="entry name" value="LLPH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="64"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="64"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="108"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="126"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00034118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5099425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="147" mass="17029" checksum="791ED6B139D0DF9F" modified="2022-05-25" version="1">MAKSLRSKWRRKCRAVKRERYGAKELATLKKTLGIDENGQQEVELNEISEIATVVDAKTIKAENEMKADKNDNENHVEQMDQDGKRVYNKKTMKDQYGQYPIWMSSRKIAKHKKGRGKNLSATSKSSKRLTKRQKKMVKKKGNSQNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MT28</accession>
    <name>A0A8J2MT28_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Similar to jar: Myosin heavy chain 95F (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">HICCMSTLAB_LOCUS12328</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5106575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6108017at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030139">
        <property type="term" value="C:endocytic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016459">
        <property type="term" value="C:myosin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000146">
        <property type="term" value="F:microfilament motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030048">
        <property type="term" value="P:actin filament-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009653">
        <property type="term" value="P:anatomical structure morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048513">
        <property type="term" value="P:animal organ development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048731">
        <property type="term" value="P:system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009888">
        <property type="term" value="P:tissue development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd21759">
        <property type="entry name" value="CBD_MYO6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01382">
        <property type="entry name" value="MYSc_Myo6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21958">
        <property type="entry name" value="MyUb_Myo6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22249">
        <property type="entry name" value="UDM1_RNF168_RNF169-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.820:FF:000001">
        <property type="entry name" value="Myosin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.530:FF:000006">
        <property type="entry name" value="Putative unconventional myosin-VI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000018">
        <property type="entry name" value="unconventional myosin-VI isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.820">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.4820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.530">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1590">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.220.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.360">
        <property type="entry name" value="Myosin S1 fragment, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.720">
        <property type="entry name" value="Myosin VI head, motor domain, U50 subdomain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049016">
        <property type="entry name" value="MYO6_lever"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032412">
        <property type="entry name" value="Myosin-VI_CBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001609">
        <property type="entry name" value="Myosin_head_motor_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008989">
        <property type="entry name" value="Myosin_S1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036114">
        <property type="entry name" value="MYSc_Myo6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140">
        <property type="entry name" value="MYOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140:SF745">
        <property type="entry name" value="UNCONVENTIONAL MYOSIN-VI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21521">
        <property type="entry name" value="MYO6_lever"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16521">
        <property type="entry name" value="Myosin-VI_CBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00063">
        <property type="entry name" value="Myosin_head"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00193">
        <property type="entry name" value="MYOSINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00242">
        <property type="entry name" value="MYSc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51456">
        <property type="entry name" value="MYOSIN_MOTOR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="6 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0112">Calmodulin-binding</keyword>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 11" id="KW-0505">Motor protein</keyword>
    <keyword evidence="8 11" id="KW-0518">Myosin</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myosin motor" evidence="13">
        <location>
            <begin position="55"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="domain" description="Myosin motor" evidence="13">
        <location>
            <begin position="1212"/>
            <end position="1920"/>
        </location>
    </feature>
    <feature type="region of interest" description="Actin-binding" evidence="11">
        <location>
            <begin position="645"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="region of interest" description="Actin-binding" evidence="11">
        <location>
            <begin position="1798"/>
            <end position="1820"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="837"/>
            <end position="982"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="1945"/>
            <end position="2015"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="149"/>
            <end position="156"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="1306"/>
            <end position="1313"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CAG5106575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="2068" mass="238380" checksum="21431A7A99DE3FE0" modified="2022-05-25" version="1">MDNQQVWVRDQKEGFIIGKFTDMVDGDALIVPLDPKYPQRTCPLDEVYPAGEYTKDVEDNCALMYLNEATLLNNIRTRYFKDKIYSYVANILIAVNPYCPVKDLYSRQTIKAYQGKSLGETPPHVFAIADKSFRDMKVLKQSQSIIVSGESGAGKTESTKYLLRYLCDLWGSTAGPIEQKILDANPVLEAFGNAKTKRNNNSSRFGKFMEVHFDNKCQVVGGFISHYLLEKSRICLQSPDERNYHIFYMMCAGAPAELRSKLGITKPDDFHYLKNGCSQYFCNEKSEKKLNEAQKSQNHLEKGGLSDPILDDVDGFSTVDQAFTRLGLTEVERMEIYTMVAAVLHLGNIVFEDNPEDTRGGCRIAGTTAKSVTMSAKLLGVDPEELKEALVSKVMQTSRGGYKGTVIMVPLKIYEANNARDALAKAIYSKLFDHIVMRINKSIPFKASSYYIGVLDIAGFEYFKVNSFEQFCINYCNEKLQQFFNERILKFEQELYAKESLNIPKISYVDNQDCIDLIEAKMNGIFSLLDEESKLPTQSFAHFTSEVHRTWNGHFRITLPRTSKLKAHRELRDDEGFVIRHFAGGVCYQTNQFIEKNNDALHASLEGLIQESGNNFLRTQFANHSASQKGKLTFISVGSKFKTQLGELMDKLKSNGTNFVRCIKPNNEMVDHSFDGSSILGQLRCSGMTSVLELMEHGYPSRVPFQELYNMYKSYLPPELAKLEPRFFCEALLQSLKLNNKDFKFGITRVFFKPGKFAEFDRIMKSDPENLKKLVAEVKKWLLKSRWNKIQFCALSVIKLKNKIIYRRNHLIVIQKNARMFIAMKQHQPRINGIMKIKNLKSQLIEMQEIANQLKSARDKSIEDIKNLQLEIDVALKKIKMEQNIKSTEIENLYTKLRIAVNNEMTNLQDKVQQQKVEEQKLRKLQAEMEIERKKKAEELAKKKEEEENKKKKMDIEARRKAEEEQRKRLEEEDQKAALSLQAQLEKEAMEESHYRELLEQERRDHDLAVRLAQESNGQVEDSPPPIRKSEQVRNHQAMMANKKYDLSKWKYSELRDAINTSCDIELLEACRHEFHRRLKVYHAWKARNRRRTTMDENERAPKSIMEAAARSSRNPLKHQITETSQRFFRIPFVRPNAAGQTENPNAGSKRGWWYAHFDGQYVARQMELHPDKPPILLVAVWVPDPKEGFKLIEKTNVAASNVKYPVGDPNKNEDDNCALMFLNEATLLNNLRIRYAQDKIYTYVANILIAVNPYYPIQELYSEDTIKKYPGKSLGEEPPHIFAIAEKSFQDMKMNKSSQSIIVSGESGAGKTESTKYLLQYLCKLKGSSDNSLEQKILAANPILEAFGNAKTQRNKNSSRFGKFMEVHFAENFQIVGGSVSHYLLEKSRICLQNSDERNYHIFYMLCAGAPLKLHKKLGISKPDDFLYLKNGCNQYFCNKESEKKLSQSQKSQSHLAKGCLSDSDLDDVEGFNKVDQAFTRLGLTEVERIEIYSTVAAVLHLGNICFETIPNDPSEGCRITAETINLVEKSANLLRVDSNELKEALVSHKRQSIQKVEVIESLLRPDQAENARNALAKAVYSELFNYIVSRVNKSIPSESHEYYIGVLDIAGFESFEVNSFEQFCINYCNEKLQQFFNQRVLKSEQDTYKAEKLNVPKITYVDNKECITMIEDSEKGIFSLLENFLRRSDSTPEEFTNLVHQTWDRKDKLKQLSTKCRALYALKQDEGFLINHFAGEVCYQTSQFIEKNNDALNSSLQELIQKSGHEFLQTGFATDPASKTKKRVIHSVGSKFKKQLRDLMDELKKNETNFVRCIKPNNKMEPRKFDGSCVLSQLKYSGMTSVFELMGHGYPSRVYYEELYKVYEKFLSTPDLAGLKEKDFCEALVQSLELKETEDFKLGEKRVFFKPGKFAEFDKIMKSDEKKMKQLVINMRKWLRKSRIAKLQNLKEQVLKMKEIANQLESTGNKRIEANDQVRRRTRTAKKKKEEQRLAEIKAEEERRRQEELAGNRLEEARKATDIPDPSKWNYSQLYAGFYSNDPNKKAASLIEIRKRLDIYHNWKAENNIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MTR3</accession>
    <name>A0A8J2MTR3_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS12856</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5107663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MTR3"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5107663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="159" mass="18602" checksum="F90AEB120F4BBF7D" modified="2022-05-25" version="1">MVNMLHQRSTVYKQKMKIIEEKDLNTKRDTGETSLFAIREYKKEKKSSGEAEEVDERLVAAKKVTGVYITIKTGFMIQTGTRDERQEFKQSNPVYLLVWPWSFCCRCLKPVCRKRFSGRQQRFARAGDFCGPILNCWRRDQAIQSIVWCVCVLCSWGTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MXM1</accession>
    <name>A0A8J2MXM1_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 17">Vesicle-fusing ATPase</fullName>
            <ecNumber evidence="4 17">3.6.4.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">HICCMSTLAB_LOCUS11705</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="16 17">Required for vesicle-mediated transport. Catalyzes the fusion of transport vesicles within the Golgi cisternae. Is also required for transport from the endoplasmic reticulum to the Golgi stack. Seems to function as a fusion protein required for the delivery of cargo proteins to all compartments of the Golgi stack independent of vesicle origin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15 17">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="17">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="17">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homohexamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 17">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 17">Belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.6" evidence="4 17"/>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5103829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MXM1"/>
    <dbReference type="OrthoDB" id="9982946at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005795">
        <property type="term" value="C:Golgi stack"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043001">
        <property type="term" value="P:Golgi to plasma membrane protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035494">
        <property type="term" value="P:SNARE complex disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000026">
        <property type="entry name" value="vesicle-fusing ATPase isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000031">
        <property type="entry name" value="vesicle-fusing ATPase isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000166">
        <property type="entry name" value="vesicle-fusing ATPase isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.40.20:FF:000012">
        <property type="entry name" value="Vesicle-fusing ATPase protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000187">
        <property type="entry name" value="Vesicular-fusion ATPase SEC18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009010">
        <property type="entry name" value="Asp_de-COase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029067">
        <property type="entry name" value="CDC48_domain_2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003338">
        <property type="entry name" value="CDC4_N-term_subdom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054419">
        <property type="entry name" value="NSF_ATPase_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039812">
        <property type="entry name" value="Vesicle-fus_ATPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23078:SF3">
        <property type="entry name" value="VESICLE-FUSING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23078">
        <property type="entry name" value="VESICULAR-FUSION PROTEIN NSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02359">
        <property type="entry name" value="CDC48_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21964">
        <property type="entry name" value="NSF_ATPase_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01073">
        <property type="entry name" value="CDC48_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50692">
        <property type="entry name" value="ADC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54585">
        <property type="entry name" value="Cdc48 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 17" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13 17" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="10 17" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12 17" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14 17" id="KW-0653">Protein transport</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 17" id="KW-0813">Transport</keyword>
    <feature type="domain" description="CDC48 N-terminal subdomain" evidence="19">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="18">
        <location>
            <begin position="250"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="18">
        <location>
            <begin position="533"/>
            <end position="669"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00056429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU367045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="SMART" id="SM01073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="CAG5103829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="738" mass="81806" checksum="FFFEDB0E6C846468" modified="2022-05-25" version="1">MRAIRCPTDELSLRNCAAISPVDFPKDVKYIEVTTLPNQNYVFTVETHNDVPRGCVGFSLPQRKWAALSVDQEIDVRPYQFDASSSSNFLGTIVLEADFLQKTKTTTEPYDTDLMVKDFLFKFSGHAFTVGQQLAFQFGDKKMLGLVVRDLEALDVTAIEQGQKSKPKKTRMGRCLGDTVIQFEKAESSCLNLIGKAKGKVVRQSIINPDWDFAKMGIGGLDKEFSAIFRRAFASRVFPTDIMTQLGCRHVKGILLYGPPGTGKTLMARQIGTMLNAREPKIVNGPQVLDKYVGESEANIRRLFAEAEEEEKKLGPNSGLHIIIFDEIDAICKSRGSVAGNTGVHDTVVNQLLSKIDGVEQLNNILVIGMTNRRDMIDEALLRPGRLELQMEISLPDETGRFQILNIHTSRMREHNKIAPDVDLKELAVRTKNFSGAELEGLVRAAQSTAMNKLIKVSSKVELDPSAMEKLMVSRADFLHALENDVKPAFGTAAEVLDHLLARGIINWGRPVAEIIADGSLDIQKTRAAEGFGLVSVLLEGPPNSGKTALAAQIAKNSDFPFVKVCTPDDMVGHTETAKCLAIRKFFDDAYRSQLSCILVDNIERLLDYGSIGPRYSNLTLQALLVLLKKQPPRGKKLLVLCTTSDRQVLDDMKLISAFNTVLHVPNLSTPDHLLAVLEDQDVFTKQELTMLHAKLQGKRVFIGIKKLLGLIDMARQVEPSYRIPKFLSKLEEEGGLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MYC8</accession>
    <name>A0A8J2MYC8_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to GCNA: Acidic repeat-containing protein (Homo sapiens)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS11514</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5103447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MYC8"/>
    <dbReference type="OrthoDB" id="20772at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00084">
        <property type="entry name" value="HMG-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006640">
        <property type="entry name" value="SprT-like_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035240">
        <property type="entry name" value="SprT_Zn_ribbon"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23099:SF0">
        <property type="entry name" value="GERM CELL NUCLEAR ACIDIC PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23099">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10263">
        <property type="entry name" value="SprT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17283">
        <property type="entry name" value="Zn_ribbon_SprT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00731">
        <property type="entry name" value="SprT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SprT-like" evidence="2">
        <location>
            <begin position="857"/>
            <end position="1017"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="73"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="159"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="204"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="291"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="415"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="506"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="656"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="170"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="204"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="221"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="294"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="312"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="356"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="419"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="509"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="553"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="563"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="618"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="656"/>
            <end position="667"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5103447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="1085" mass="122240" checksum="82358254EA2F292E" modified="2022-05-25" version="1">MEKCNNTKGQTTNRRYPLSVENKIYDNDNDKNLSSISDRYNKIYDKILNITSDCDNSQDFVLQVTDSIFVRETSDENNKNHNNKKTQEVKSSEVIIISDSSDDESFSPANNKGNTILPSKKIGETKRTPSLTISSINSSDILTEDESHKKPKTNYIFTSTQLNNDDRRNNGSVTNDSGNGTPLGFNYLSEKDLRTPNINQIMRSESLTKLPNPSPRNNASADRKKLEPMSDKRERVPAETKGSSVDKVLSKQTNDARIIPGFTKRNPATPVNKKATREILKAVKSKRIVYDSPGQWQKNKAPNNYNSPGLMRNKDIINKSELETSNSSSESKKEDQSEFQHPAWIDETISEISDSREDDCDNKEEDCERPAINVTETRVIGYLNPIERQSLSPSERKKEDIARWLMSTAFDQRSDTSLSIIGPSQPNSPGSGNSSLERLEHNYQTPNNRTKFQAKINSATSVNSKTNDNTPIAGGQLKQLEPVQRTKVCTPSTGDVKRLEPAWKKNVDRNTPNLGGNLKPTSKANTPSTGGNFKRSEPGRSRVATPISGGNLKRLEAVDRKNINTPSTGGNSKSLNKPVQKTMDNFVKKTKPRPRTPKNLTPLSITKTAAKTPRSEDQATNDSSNTNAPSLRIEDCEDILTRLYGDSWRKNADALLPKESRTAPRTDKVKKKVHDTARRRSDKIVKSIKPVISRKEKKPPPNVRNIRDSFINDWPSSEDDAVETSFVTALSTPIPPSHTIRRKETPMSELQKKVIEICDSDSDDDKTPVVKNTRKRLSFGDDKSSGSFTSEYDPGEVILPKPVSRVKNLPTSKLSPVVFKQPAVIASFIKSLSKEVALEKVHPEAKKYRLNYKLTKDELCQRLYKIFNEKVFDSQLPENMSIEWNARMRRTAGFCYNKMIRSAIGKPERSSRIVLSSKILDEPNRLRDTLIHEMCHAATWLINEISDGHGLYWRSWASKALKVFPELPPITRCHDYKITTKYTYRCVDCGYSIGRHSKSLDISRKRCGHCFGKFELLVNRTTRSGRVELKTPNAKQPSGFALFVKENYGTVRKECKDSNHQGVMKILGQQFSAVKISKQNDKDDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MYT7</accession>
    <name>A0A8J2MYT7_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Metalloendopeptidase</fullName>
            <ecNumber evidence="11">3.4.24.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HICCMSTLAB_LOCUS13248</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="10 11">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="10 11">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="11"/>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5108460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MYT7"/>
    <dbReference type="OrthoDB" id="291007at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04280">
        <property type="entry name" value="ZnMc_astacin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.390.10:FF:000015">
        <property type="entry name" value="Meprin A subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034035">
        <property type="entry name" value="Astacin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001506">
        <property type="entry name" value="Peptidase_M12A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006026">
        <property type="entry name" value="Peptidase_Metallo"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127">
        <property type="entry name" value="DISCOIDIN, CUB, EGF, LAMININ , AND ZINC METALLOPROTEASE DOMAIN CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127:SF780">
        <property type="entry name" value="METALLOENDOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01400">
        <property type="entry name" value="Astacin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00480">
        <property type="entry name" value="ASTACIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00235">
        <property type="entry name" value="ZnMc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51864">
        <property type="entry name" value="ASTACIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8 10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 10 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 10 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 10 11" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1 10 11" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0732">Signal</keyword>
    <keyword evidence="5 10 11" id="KW-0862">Zinc</keyword>
    <keyword evidence="7" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035342577" description="Metalloendopeptidase" evidence="11">
        <location>
            <begin position="25"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M12A" evidence="12">
        <location>
            <begin position="109"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="205"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="204"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="208"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="214"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="152"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAG5108460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="328" mass="37771" checksum="B260CF1BACC7D70C" modified="2022-05-25" version="1">MKLINILTSFIVIILILFLNSSTCNYGVTAFNSHRSKLQLDEQLRKSVPPKVHYSGKNYDSSYNSDEICKFNIIIRVNEWSTDDIENVWELSGLFEGDIMPNSDSKIRNGLVDEAMRWPNGSIPVYIDRDNFDEDDVESIMGAIDEFHEKTCLVFHPYDNKTDKNYVIFRGNQAGCWSSVGKQNEGQVINLQNPGCLSHGTIVHEILHAVGFYHQQSTYDRDQFVKINWENIKPGREHNFNKYDNRTVTNYKTEYDYNSVMHYSKKAFSQNGNETITPLKPGVEIGQRKSMSKKDLFKVRMMYKDHCKGRKPQGVIASVPLRITSLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>S6D9L8</accession>
    <name>S6D9L8_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cc_ptp.e_10.1</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">Protein tyrosine phosphatase PTPE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">ptpe</name>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS1880</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Philos. Trans. R. Soc. Lond., B, Biol. Sci." volume="368" first="20130047" last="20130047">
            <title>Functional endogenous viral elements in the genome of the parasitoid wasp Cotesia congregata: insights into the evolutionary dynamics of bracoviruses.</title>
            <authorList>
                <person name="Bezier A."/>
                <person name="Louis F."/>
                <person name="Jancek S."/>
                <person name="Periquet G."/>
                <person name="Theze J."/>
                <person name="Gyapay G."/>
                <person name="Musset K."/>
                <person name="Lesobre J."/>
                <person name="Lenoble P."/>
                <person name="Dupuy C."/>
                <person name="Gundersen-Rindal D."/>
                <person name="Herniou E.A.Drezen.J.M."/>
            </authorList>
            <dbReference type="PubMed" id="23938757"/>
            <dbReference type="DOI" id="10.1098/rstb.2013.0047"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CAJNRD030001116">
        <property type="protein sequence ID" value="CAG5075825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="HF586474">
        <property type="protein sequence ID" value="CCQ71299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S6D9L8"/>
    <dbReference type="OrthoDB" id="6928550at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009653">
        <property type="term" value="P:anatomical structure morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048666">
        <property type="term" value="P:neuron development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050348">
        <property type="entry name" value="Protein-Tyr_Phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000242">
        <property type="entry name" value="PTP_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19134">
        <property type="entry name" value="RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19134:SF449">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00102">
        <property type="entry name" value="Y_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00700">
        <property type="entry name" value="PRTYPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00194">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50055">
        <property type="entry name" value="TYR_PHOSPHATASE_PTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="1">
        <location>
            <begin position="53"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="2">
        <location>
            <begin position="194"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5075825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCQ71299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="320" mass="36996" checksum="1D1C4147EE188215" modified="2016-04-13" version="1">MAPRIFETHHSCQYFEQVAESRTRYVERICREHHTILNMQISGPCKECKKLKNIKKNRFQNIECWDSTRVCLKKQGSNYIHANYVDGFEQARKFIVTQEPMDNTLEDYWNMVWQTSTRVIVMLNGADVPAVSTVSDYSELEGFTVTVTSIALQSDYVEMVMNVFNIKTMRSRTVHCFKYLSWPKESVADILTLINFIIVVNERHQYHIKLGLISPPGPIVVYSTTGIGRAPTFCAVDICMFQLVNTATVSIPAVVFNIRRQRRSSFESFEHYVFINNLIVYFLATIPPNCELSKRLFCHRLGESARFFLSSPPTVNRLNC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2E1H4</accession>
    <name>A0A8J2E1H4_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Similar to FANK1: Fibronectin type 3 and ankyrin repeat domains protein 1 (Bos taurus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HICCMSTLAB_LOCUS805</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001114">
        <property type="protein sequence ID" value="CAG5074033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2E1H4"/>
    <dbReference type="OrthoDB" id="9995210at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="186"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG5074033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="449" mass="51028" checksum="25710BA8AB8770EF" modified="2022-05-25" version="1">MREDSLSRLVTLIYDESGSTTQSGKFPGMMKLRTILLASPGSPTVVGKDEYLSRSTVRTQRIKNGELSKDAVLTIPPIEFEPYYSFDFPKSERNKSLPILHFAIGFDDKKMIDYLLSFHQTVDKIQPALLFAIKHSEINIVEKLLAAGGNINDPMLFSTAIYNNRIEIANFLIDQGALCDSKISFEGCSSLVIAAKHNYVNLMKILIDNGADVNFLSSNRGKNSTWTPLMAACSTSAREAIEILLNHPNIDVNIVDHNRENCNFYINTLSSMSKINHNLLLNTNININIRNINGKLLIESSPSLALIFHIVALMVAGLDVSERNIEASGARIYKKLQAKYLQEIELLKSTKELMTNWSCFRILRTSQHLLALRFKHLQIPEHQGEEWSEKFPIYGKMLAFNFKKALQRKILLKKTDQVLFDILYRKLPATFINDLYHYMSNYNLSKLVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2E4U0</accession>
    <name>A0A8J2E4U0_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cc_OrNVorf18</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS383</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001114">
        <property type="protein sequence ID" value="CAG5073440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2E4U0"/>
    <dbReference type="OrthoDB" id="10404980at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="252"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="337"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="252"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="345"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5073440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="387" mass="43311" checksum="8A62BCA93573D7B6" modified="2022-05-25" version="1">MKINETSRIIYQQAALRSFLRSDHIAQSFIEQSPNYNIRSLEQLYAVSTSIKSKKMIIEFVKVATKQFFIAIRYRVPGFEYLNPENINTNVTDDELMLLINDATTVNETSHLHNHSIVFLVAKNIIFNLIGVNASATLSSLLQNNQTNSVNNISFRTEPPLQNQFSTTLDSSNLVSASTSVPVSYSTSTTISQSLSKNIINGTIAQQHSSPTNTLPLTSSFLSTEVNDTKNGVTDVLPSVELQSLVACSESNASPMPVSSSSVHIDNSKPDNDIFKHSEQNETLSNSSLSSIDLTIHANTKMYNEQESLQLIDDDKNSLSEDTKYLSYDYENNNVDNISNFDYDGDQKSNYENPKHERSDPIINFDDKDEELGNSNKILDEYRDLTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2E5U4</accession>
    <name>A0A8J2E5U4_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS974</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001114">
        <property type="protein sequence ID" value="CAG5074231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2E5U4"/>
    <dbReference type="OrthoDB" id="7676665at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5074231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="276" mass="30919" checksum="38692F5B8119F026" modified="2022-05-25" version="1">MDRKNNLKNYLAAVAIFSVFAGINTAKISLGQLAAGDVVNDVNLDQLTGELVGNLFHGETGGQYVKKHLEKYWKSFSHIVAFNCKNTSIHAGYFPNINVEALKKIGFNNSKLTGNVLGIDDRYVGNDYMCFSFKFCDASVEESVLIELKNPSDYPEDVKRWIEQTGLSGAWRKNETSYVSSIFTGDCVYQILVFEKPESRIGPYNYRKHTPIHIGRISSASHNATLENWTSDLLNRTGQSLGFLKAEERAEIHKQFNNAAVIQLELKLLPAIDSQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2E9R8</accession>
    <name>A0A8J2E9R8_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Olfactory receptor 225</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HICCMSTLAB_LOCUS54</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030000415">
        <property type="protein sequence ID" value="CAG5071452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2E9R8"/>
    <dbReference type="OrthoDB" id="7540137at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005549">
        <property type="term" value="F:odorant binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004984">
        <property type="term" value="F:olfactory receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004117">
        <property type="entry name" value="7tm6_olfct_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21137">
        <property type="entry name" value="ODORANT RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21137:SF35">
        <property type="entry name" value="ODORANT RECEPTOR 19A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02949">
        <property type="entry name" value="7tm_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0552">Olfaction</keyword>
    <keyword evidence="8 11" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="9" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="68"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAG5071452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="110" mass="12894" checksum="4C9597D1ACE280E7" modified="2022-05-25" version="1" fragment="single">VGVSLIISVNDKNMVNFIKSICIMNFMLFESYLYTYPADNLANRAESMLRAIYSSNWYDMPPHVTKNLVFIMMRINLPLYLTCGKFFYMTRRSYMDVIKTSASYLSVLRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2025-02-05" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2EBH1</accession>
    <name>A0A8J2EBH1_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS535</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001114">
        <property type="protein sequence ID" value="CAG5073636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="7916681at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.120">
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40552">
        <property type="entry name" value="AT05186P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40552:SF6">
        <property type="entry name" value="FI09606P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1320"/>
            <end position="1343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1326"/>
            <end position="1340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5073636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="1704" mass="191137" checksum="659C2CF9691B7B3C" modified="2022-05-25" version="1">MESKILEEKQNFTPKKKYPHKWNNFQVISPKMAILRGNYSIFDKRFKFVSRGQQGTACCVVAIVFSRLVNPKNWTMDHVNKVLENGDKLFRLSQWRNKVKDTLMTTQMVYPEFFIDDYKCNILCEPNKVCGNLFTESAGCPLIGDGIKKFLQDHEAGVLTSSGAAVAIWRHTVEGKFWYFSPTSCDETGRQKEACLIISKDINDLVELFLTNLNDNDSRYSVDKITVVKINLINRSLPDDRGLLTINKNVRSTNTKGEKKFKVKKKDVVNKEPLAITISNYNIETTFAQDPLIDQNNFDTGYDYYDIEVNVPSTFRELSQDRAILHGWTHESADVYKGKGAQNVANCISALAIKKISPVRTWLRPKLDEILSLGDALYLEVKSLNSAKRTIDFNDRKIQIDGKSHFVDVDLITVTGTLASKVPDVLNLKQALLEFFLVNTDGVVQCSSMAIAVWTQNGCYYSFDPRQCDANGDRVREEPKRKQKKDTEVKKKSGKCCVIRFPTVESLAYNFIDKVENKNDRFIINSVSVADDVPGTRKWREFEPGEAGKTWVLQGTISNADEDFESAGMQGIAIPVVALVTAQEVAPQDWTKAVVDQVVRDGDAFFKWCVPQEEEEEQEITLRNLKRKVYVNSRRVKFDIGEAVVVGNSEFSALAEGITKFFTEHQYGIVEFGDLVVAIWKHDQVLPKTKGKEAGTETTYYCFDANPRGPLGEKNSEEEEAACVIRAVDPEEIARRIHANAEGSGEFFIHSFQVGEISETMTPEEIEADKQKPTKPSLGDFVELDEDSACLYGSVDLDDKSQAAVALVTLGMTKLYSPFLWTREVVDDIVKLGVKVAEKNVENLPEEERVYLLPSEIEEFDIGVNRISVEAEENATGTLENLVTMLQGFLARNTAGILRQDGVMVPIWKEGDVFFTFNPRLDQETKENPTVFWFTNIAALVANIQPMFDQAGNIVLDSVNLESEYETRVAENERPKPATSDEELWYNFPKVSQGVWQLLGSVSLNDEKFLPGNHGNQTAALAAMAVIFSKVYEPKQWNKEIIDEVVVTADKLHTKTVECLGNVVNPRVNQVIPEFFLSNRRLDLTIRDCVESGKVSSNLLTLKEGLERFFQNFSSGALTLGDVNVGIWKSKDFFAVLPSSKFPGDSGDQVKVLRFKTTEQLAAYFSRLVDAEEDYEIHAIDVVDWNKFPPWKHDPSSVVRPSNLPALNAYRELPPARAILQAGIDQSSDIFPPSLRNRQTASNCVVALAMAVVKNSLTWTKKTLDEILVIGNKLHRESLKATKDKVKPGDVVRVFHIGVNALTADVEVAVAGLVAVKPPEPEVKGKKTKKPKSARGKKKTRELPPQAVPPLLQEGVQQFWEENSAGILVIGSYMVSMWMEHGVYFLWDPRPRSKQGLKISGPSEEGFACVMWFACLEPFYDVILENIDEEDKFGSFEIFRVIVNTLIVESLPGPVGFQAFVEEGTKQTVDVKVASEFFFVDKDLSVLKGSIHMNSSAFDLKYRGRQSTAIAAVANAVAVLHVPSTWTSELVDAIVRYGDVLHRDSTRIRNAECEKRNLLAKELLDSFVIGDFRVSISVSSNETAGILVVHDLAQALGVFFRNHCAGILHTSNLAVAVMQHYGKFYMFDPSECDKFGRSYYLDDVDDNDNGERKDQVGGGGACVAKCESIMRLASIFVAKEIFLACKIITKFYTMDSFKEEKEIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2EBI0</accession>
    <name>A0A8J2EBI0_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">NADH-cytochrome b5 reductase</fullName>
            <ecNumber evidence="13">1.6.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">HICCMSTLAB_LOCUS1076</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>2 Fe(III)-[cytochrome b5] + NADH = 2 Fe(II)-[cytochrome b5] + NAD(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46680"/>
            <dbReference type="Rhea" id="RHEA-COMP:10438"/>
            <dbReference type="Rhea" id="RHEA-COMP:10439"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.6.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 12 13">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.6.2.2" evidence="13"/>
    <dbReference type="EMBL" id="CAJNRD030001116">
        <property type="protein sequence ID" value="CAG5074843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2EBI0"/>
    <dbReference type="OrthoDB" id="432685at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090524">
        <property type="term" value="F:cytochrome-b5 reductase activity, acting on NADH"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016126">
        <property type="term" value="P:sterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06183">
        <property type="entry name" value="cyt_b5_reduct_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000021">
        <property type="entry name" value="NADH-cytochrome b5 reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.80:FF:000005">
        <property type="entry name" value="NADH-cytochrome b5 reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001834">
        <property type="entry name" value="CBR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008333">
        <property type="entry name" value="Cbr1-like_FAD-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001709">
        <property type="entry name" value="Flavoprot_Pyr_Nucl_cyt_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19370">
        <property type="entry name" value="NADH-CYTOCHROME B5 REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19370:SF185">
        <property type="entry name" value="NADH-CYTOCHROME B5 REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00970">
        <property type="entry name" value="FAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00406">
        <property type="entry name" value="CYTB5RDTASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00371">
        <property type="entry name" value="FPNCR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 12 13" id="KW-0274">FAD</keyword>
    <keyword evidence="4 12 13" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 13" id="KW-0520">NAD</keyword>
    <keyword evidence="7 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="11" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="8" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="10" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="15">
        <location>
            <begin position="40"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="108"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="113"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR601834-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU361226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CAG5074843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="301" mass="34110" checksum="B73FAC7E829581D4" modified="2022-05-25" version="1">MMKNQVLMVVGAVGTLIIGGTIHYLLRRKKRVPVLLENPSKKYSLPLIEKEIINHDTRRYRFGLPSTHVLGLPVGSYVILTAEINGQPVRHAYTPVSDDNDFGFVDLIVKVYFKNVHPKFPEGGRLTQYLDEMKIGDTIDFEGPGGRLIYHGNGKFAIRLSKTDPVQHFYNFKKVVMLAGGSGIAPMLQLIRAIAKNPSDSTQVSLLFANQMEKDILMREELEQVIKDRPEQFKLWYTLDTADANWKYSTGYITADMIKEHMFPPAEDTIVLMCGPKPMISVACTPNLDKLGYDNKLRFIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2EC22</accession>
    <name>A0A8J2EC22_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS1261</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001116">
        <property type="protein sequence ID" value="CAG5075096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2EC22"/>
    <dbReference type="OrthoDB" id="7679028at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="254"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5075096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="311" mass="36430" checksum="0CFAB53DA62FE9CF" modified="2022-05-25" version="1">MQLIKVFLCCCCVFSGHFSNGSSIHSSEIKSHLINHTMELIDKGFANNSNPLIISSDLVDDQMASGNVDSGKPLIVINSDQKRKQIEGYLPSHPTYILRYESLPKLTSLIFGFMRSSTCNIKSPIFLLDVSEGTHDTNASIALGFLASLDILISYYVSYDDKKDSTMVYTLNPYTQYAPSPWNQEITFKKYFVYWTKKNWALKDKIDKVRSIPVETGLFYHYNEEIIKNLWKRKEKMEKIKENENYERVDFDNLVFYFIMFAATLLWSLVIFGIEFMVYHIHSKYLRREKERRQFIERLRTQPRIILPQVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2EC55</accession>
    <name>A0A8J2EC55_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS1405</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001116">
        <property type="protein sequence ID" value="CAG5075251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2EC55"/>
    <dbReference type="OrthoDB" id="7698696at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5075251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="258" mass="30059" checksum="12559722CB72C3CD" modified="2022-05-25" version="1" fragment="single">YIRKFTNDIFIPSLEQQICSLLQGKCNSDVINDVKANFNYSKTLFDFVSTEHLRFEVYKKMGCFIEPENFIIGQTEVEKIEDEKLRIENEDVYAVHIPLGRKLSLFLEIPGVFSEIQNNILSLRQEKTVFSNIMQGSLWEKRSASHKDKLCLPINIFFDEVETKNPLGSHPGRNKIGVTYATLPCLPAHLVSRLNCIFLSTLFYGNDRKIFGNKWVFRKLIEDIKSLQRLKDKCIFNIKKHFHVCENVSVDIMHDYID</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2EHP2</accession>
    <name>A0A8J2EHP2_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to TNXB: Tenascin-X (Homo sapiens)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS1914</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001116">
        <property type="protein sequence ID" value="CAG5075892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2EHP2"/>
    <dbReference type="OrthoDB" id="504708at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006149">
        <property type="entry name" value="EB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39069">
        <property type="entry name" value="ECDYSONE-INDUCIBLE GENE E1, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39069:SF8">
        <property type="entry name" value="FI17111P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01683">
        <property type="entry name" value="EB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035230353" evidence="1">
        <location>
            <begin position="20"/>
            <end position="1030"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="2">
        <location>
            <begin position="230"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="2">
        <location>
            <begin position="270"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="2">
        <location>
            <begin position="351"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="2">
        <location>
            <begin position="446"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="2">
        <location>
            <begin position="539"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="2">
        <location>
            <begin position="588"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="2">
        <location>
            <begin position="713"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="2">
        <location>
            <begin position="828"/>
            <end position="862"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="2">
        <location>
            <begin position="985"/>
            <end position="1027"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5075892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="1030" mass="114841" checksum="75AA8ABB846EA3FF" modified="2022-05-25" version="1">MNKKISVAGGLALLFIVNAVQKDALNQCANFGDACGLDLKRHCCDDSLKCAWSHSATEIHILIFGSYLLGELAILGGNCRTNEDCNYVLHSTCSSGICVCRQNNIRVSETKCMPLLNEFCWKEQCAPDNSLYSSIEVLMLSVMLGASCRDDEACTTIKFATCASNGTCACSERTVMIGPMLCSLLLEDTCGSNSECRVPNSECIDQKCQCKLRYIVASRAECKNAYVGMYCEDSSYCHSNIDNTQCVGHRCECSANYGPKNGNECLSLSRCDSDSDCKLKNFKCIDNECQCKPNYLLQEIKCLPRYLGGLCEVSSDCINIDYAVCKRNECTCENGFFPINRSQCGRGLTVECSKDEECIIINSQCMKNKCRCRDGYTQSSAKFCLPSEFSLNGVNVITVYANICTITEYFQGFCSTDDQCKSIPNSHCSKNNQCICRENAQQSSSACAPSLNQSCSIANQCITENSMCIDNVCQCRDGYISESNDKCIIMTPLSNNRILEYSEKSCVVSADCTAISNAMCSNKNKCVCKPHYVRSEQFKCSLQLEAYCQQDGDCITKNLTCFDEDCRCPKEFFQVSDNLCARGFIGQFCSADEDCDMITNGRCSEEKMCACKSGYAKFDALVCLPLIGEYCNEHKDCYVYNSNCVDNKCQCLENHMPLSNTKCLSKYVSRSCYDNVDCLAINYSHCSRYDLCVCNHNYMVDKRGFCKPALNGHCLESLQCQIANSQCINSKCQCMKNFVSGIYNNCIPSKCKIFCEKFFGTPLWHKTLTPVIRLNVHDLLLARLGKYCTSDGDCAAIKFSHCTGNKCVCKKNYETVDNAACKPLLNCFCTTDKDCIVENSYCIDNKCKCKPDYAMQSLSRCEPRVLGQTCETDSHCSFIQQGKCSPDNICVCSLDTFALDNKTCSPLLNTFCQFNEYELEFSHCVDYKYQCKLGYTAISSSQCINSNLLEPCERNDDCLELWHFECSKEKKCVCKADNVAVGNSTCLPLLGGICWQDDQCRAENSLCDDYHCRCKPNFISVASNKCVPDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2EIQ8</accession>
    <name>A0A8J2EIQ8_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CARD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS658</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001114">
        <property type="protein sequence ID" value="CAG5073886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2EIQ8"/>
    <dbReference type="OrthoDB" id="6097640at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042981">
        <property type="term" value="P:regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01671">
        <property type="entry name" value="CARD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.533.10">
        <property type="entry name" value="Death Domain, Fas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001315">
        <property type="entry name" value="CARD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011029">
        <property type="entry name" value="DEATH-like_dom_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00114">
        <property type="entry name" value="CARD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47986">
        <property type="entry name" value="DEATH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50209">
        <property type="entry name" value="CARD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CARD" evidence="2">
        <location>
            <begin position="1"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="110"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5073886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="130" mass="15053" checksum="3C1879D7AC027E3B" modified="2022-05-25" version="1">MEQEDREKIDRCIDKLVPLINMESIWPRLFLHQIFFSDDVSVPKWKDRLGTPETKREILLKIKTRGPHAFKNLIQCLRETHQENLIILLENPQSDLSMTLATMNISNNSNSASDNCCAQPSTNNNLNYDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2EK90</accession>
    <name>A0A8J2EK90_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similar to RNF38: E3 ubiquitin-protein ligase RNF38 (Homo sapiens)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS1801</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001116">
        <property type="protein sequence ID" value="CAG5075668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2EK90"/>
    <dbReference type="OrthoDB" id="8062037at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46171">
        <property type="entry name" value="GH10160P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46171:SF3">
        <property type="entry name" value="GH10160P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="191"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="353"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="524"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="583"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="27"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="213"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="231"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="264"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="357"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="375"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="535"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="593"/>
            <end position="605"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5075668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="746" mass="81163" checksum="10D7EDF0828BF4BA" modified="2022-05-25" version="1">MNPGNQHHRGMSMQGRYRNGGAGSGSGPALARSAPSSHNRSSWHSHSHNSHNQLNQHNQQFNNKEYPYRQGSSARYHNGDSGVSSSSNPTVKEVYHGPNNTNVAYKPPSHTNRVTQPPPSQSSQPSSSSHFPSDLTLTNHRRAISPPPLRINICGQESSTMRGPLMNLSPSLSVNSDLEYRRAPQAANLSALSPNVPMQSPPAYYRQSTLDTPEGRKSESPSRKRRRISRNAQVSASSMNVGSNGGPVSLAGNLENHPGHHQLASHQQEPASSTQSPPLMSNAAPWELSAPQRRSPRQHMAVRGSPPIRNRYVRCPDPLFPNGYQFFPTVQQHLHGAHHSLHNSNHNLHSGNLHGLHNTHTHHGLHGHHGHQGHQHPIQQGTGHHPSTGTNNLVVDVNQVGVSGLGVTVSGEAIWPTTGFHPARLSCHLHGTYPPPTTAHPFSYSCQITHHHHHTHYPAGPPPPGHSLIAATARGYAAPSGVPTIHAHPPPPVHTTHYTAHHQIPQQREVDPELIDGSHVHYHHPHVHRVGGNGPPGPPPPQPQPPPPMTLSHSYSPPALAAQVASPSPMFLPETRNNQMELMQPRTRRSAVGRNQNRSRQNPHSNWRRGGGAPPMPPPYPAGLLFHFLAMFSNPPLSSYSQTDMSSPENAETENYEALLSLAERLGEAKPRGLTRAEVDQLPSYKFNAETHQGDQTNCVVCMCDFEPPQTLRSNRTCPICRGDAAEYYSSPNGVNGGGSSTTSGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2EKD5</accession>
    <name>A0A8J2EKD5_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS1685</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001116">
        <property type="protein sequence ID" value="CAG5075531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2EKD5"/>
    <dbReference type="OrthoDB" id="7634014at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5075531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="91" mass="11132" checksum="EF1ED357D8327333" modified="2022-05-25" version="1">MDNVCQVYFQTRKKNLRDIYTLWAIITFVRDEDSAEFLRWCRAFNVKHLRECRDEKIVQKKKLSRTEKICLEKRILRVLQELFYCGCLPNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2GZK0</accession>
    <name>A0A8J2GZK0_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Polypeptide N-acetylgalactosaminyltransferase</fullName>
            <ecNumber evidence="13">2.4.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Protein-UDP acetylgalactosaminyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">HICCMSTLAB_LOCUS691</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="13">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 13">Golgi apparatus membrane</location>
            <topology evidence="2 13">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="13"/>
    <dbReference type="EMBL" id="CAJNRD030001114">
        <property type="protein sequence ID" value="CAG5073919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2GZK0"/>
    <dbReference type="OrthoDB" id="6119243at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004653">
        <property type="term" value="F:polypeptide N-acetylgalactosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006493">
        <property type="term" value="P:protein O-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23462">
        <property type="entry name" value="beta-trefoil_Ricin_Pgant9-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02510">
        <property type="entry name" value="pp-GalNAc-T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.80.10.50:FF:000096">
        <property type="entry name" value="Polypeptide N-acetylgalactosaminyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.80.10.50:FF:000124">
        <property type="entry name" value="Polypeptide N-acetylgalactosaminyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000053">
        <property type="entry name" value="Polypeptide N-acetylgalactosaminyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045885">
        <property type="entry name" value="GalNAc-T"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000772">
        <property type="entry name" value="Ricin_B_lectin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11675">
        <property type="entry name" value="N-ACETYLGALACTOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11675:SF131">
        <property type="entry name" value="POLYPEPTIDE N-ACETYLGALACTOSAMINYLTRANSFERASE 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00652">
        <property type="entry name" value="Ricin_B_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00458">
        <property type="entry name" value="RICIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="Ricin B-like lectins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50231">
        <property type="entry name" value="RICIN_B_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 13" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="13" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8 13" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="5 13" id="KW-0430">Lectin</keyword>
    <keyword evidence="12 13" id="KW-0464">Manganese</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="13" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Ricin B lectin" evidence="14">
        <location>
            <begin position="369"/>
            <end position="491"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU361242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CAG5073919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="498" mass="56940" checksum="A57604C63ABC56F7" modified="2022-05-25" version="1">MLEVISNQLSCKQPGRYRTDLPATAVVICFHNEAWSVLLRTVHSVLDRSPEHLIQEIILVDDYSDMPHLKRQLLDYMMNYPKVKIIRASKREGLIRARLLGAAAATAPVLTYLDSHCECTEGWLEPLLDRIARDPTTVVCPVIDVIDDTTLEYHWRDSGGVNVGGFDWNLQFNWHAVPEREKKRHKNSAEPVWSPTMAGGLFAIDRAFFERLGTYDSGFDIWGGENLELSFKTWMCGGTLEIVPCSHVGHIFRKRSPYKWRSGVNVLKRNSIRLSEVWLDEYAQYYYQRIGHDKGNYGDVSERKQLRSKLGCKSFKWYLDNVYPELFIPGEAVASGEIRNLGEGGNTCLDSPARKSDLHKPVGLYPCHRQGGNQIRNLDKEVCIDSSGKPEDLHQPVGLWPCHRQGGNQYWMLSKIGEIRRDESCLDYSGTDVILYPCHGSKGNQQWIYNSQTKQIRHGSSDKCMSITESKQRLLMEECSPSAPRQRWSLENYNPSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2GZT3</accession>
    <name>A0A8J2GZT3_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Methionine--tRNA ligase, mitochondrial</fullName>
            <ecNumber evidence="1">6.1.1.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Mitochondrial methionyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HICCMSTLAB_LOCUS1070</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>tRNA(Met) + L-methionine + ATP = L-methionyl-tRNA(Met) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:13481"/>
            <dbReference type="Rhea" id="RHEA-COMP:9667"/>
            <dbReference type="Rhea" id="RHEA-COMP:9698"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78530"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.10"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.10" evidence="1"/>
    <dbReference type="EMBL" id="CAJNRD030001116">
        <property type="protein sequence ID" value="CAG5074837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2GZT3"/>
    <dbReference type="OrthoDB" id="24670at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004825">
        <property type="term" value="F:methionine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006431">
        <property type="term" value="P:methionyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0065003">
        <property type="term" value="P:protein-containing complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00814">
        <property type="entry name" value="MetRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.220.10:FF:000001">
        <property type="entry name" value="methionine--tRNA ligase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.220.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.730.10">
        <property type="entry name" value="Isoleucyl-tRNA Synthetase, Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010591">
        <property type="entry name" value="ATP11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014758">
        <property type="entry name" value="Met-tRNA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023457">
        <property type="entry name" value="Met-tRNA_synth_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015413">
        <property type="entry name" value="Methionyl/Leucyl_tRNA_Synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033911">
        <property type="entry name" value="MetRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00398">
        <property type="entry name" value="metG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43326:SF1">
        <property type="entry name" value="METHIONINE--TRNA LIGASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43326">
        <property type="entry name" value="METHIONYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06644">
        <property type="entry name" value="ATP11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09334">
        <property type="entry name" value="tRNA-synt_1g"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01041">
        <property type="entry name" value="TRNASYNTHMET"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methionyl/Leucyl tRNA synthetase" evidence="12">
        <location>
            <begin position="321"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="70"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="70"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00026124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF09334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAG5074837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="844" mass="96535" checksum="0E509B6970A3BFF6" modified="2022-05-25" version="1">MSKILSLRLLNSSVVNNNFFYKNIMTSSAVRAKKLLEGLKDNPYFDKYAGAIAKLQQTNPDEFISRIEETEKKKRPSKSKESAAKINKEASAKPSLSSDLKQTKVSRLSDVMKLELLEDKGKQEITDIWLNYHKQKDCICGVMEPETFDLMFERGSQYPTFILPLPRENGYEFILSQFSGNEIHMTPLLWYQTHQENAPECLTIVHYTDLRDYKGIVLMKGEFDSKTINVQEAQCLANELQLYYAKDNPERLKLLETFTKHPDQFKHMDLVKQQVFYYHHYYYSFTASKLMTPLMRSVSNNKSWINKTFTRTYVDYRPKNVYLTTPIFYVNAGPHIGHLYTASLADALARYNRMLGHQVFLSTGTDEHGNKVSDAANANNLSPQNYTDKISGLFKDMCDNFDISYSNFIRTTDLRHHQAVNHFWTTLKENGHLYLGKYSGWYCVSDEAFVPESELLEKVSNGKTIKVSAASGNLVQWMEEDNYKFKLSSMQDDLKYWLKNVKAVEPIKFHKILTSWIEEGSCLEDLSVSRPVSRAPWGIKVPNDNSHTIYVWLDALVSYLTSLGYPKNQEFAKFWPPTVQIIGKDILKFHGVYWPAFSMAAGLDPPRTLLCHSHWTVDDEKISKSKGNVVSPSEAANKLFTADGLRYFLLREAVPHSDANYSEDKIRKILNAELADTLGNLVSRCMGKALNPGKIIPEPCVRHAETLGSDEALKLVESLENLSSVAHNHYNNFNLHSVVDTVMQSLFLANKMIDHDKPWTLAKQTDNPEAQKKLESVLALGLEAARLGSLILTPIIPQLTSHLLDFLNVPSNARMWDNTKYLNTGRNDQINTPKQDYAFFKKLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H1F3</accession>
    <name>A0A8J2H1F3_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS466</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001114">
        <property type="protein sequence ID" value="CAG5073523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H1F3"/>
    <dbReference type="OrthoDB" id="7705942at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="153"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="436"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="158"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="234"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="318"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="344"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="354"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="436"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5073523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="460" mass="51971" checksum="55A248DE592D0A3E" modified="2022-05-25" version="1" fragment="single">YKKVLEKVYLDSDGKIVKKPKKKNDKKTIEADKNLVGSKSIFEKFGPVDQELTNSPSESGTQQIVVEAVIEHEPSVSAGVKNVLQKSKYDKNIKCDSLPLMKKSSDENFDIIESIQTVDLSSTDDKSINKPKRIRWRDNGVIKNKITIKSQDTTVSEIRGDPKDSQKTKIDEVKDSVEKIEKKSIPTETNSHFKPKTDSKCHQKSYLNSKKDLVVENNKSNVYPSSFDIGDQENPEHIKEGDAYSDKNDIIEENNKLDSLLSSSDSEDEPSPEKSVIVDDTSVVRKRRKRVIPISSSDSEDEPNSVNIEAAPGGSKNYNRKGNSKSKIMHKKSNREPEKLNYSDIYSDTASNDSSKKQEEINNDKTRDNTGKENKQLRARKGRSSESFIENVIAHGPTLFDHNDQSRSSLIITQDNIDFLENLLQYVKCLYEKQTTEPASLPSVSRRNDCDNRKSKFKAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H3I6</accession>
    <name>A0A8J2H3I6_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="11">CYP369B1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HICCMSTLAB_LOCUS1947</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001116">
        <property type="protein sequence ID" value="CAG5075958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H3I6"/>
    <dbReference type="OrthoDB" id="1103324at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016712">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008395">
        <property type="term" value="F:steroid hydroxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006082">
        <property type="term" value="P:organic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006805">
        <property type="term" value="P:xenobiotic metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050182">
        <property type="entry name" value="Cytochrome_P450_fam2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24300:SF376">
        <property type="entry name" value="CYTOCHROME P450 15A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24300">
        <property type="entry name" value="CYTOCHROME P450 508A4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8 9" id="KW-0349">Heme</keyword>
    <keyword evidence="6 8 9" id="KW-0408">Iron</keyword>
    <keyword evidence="4 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035315744" evidence="10">
        <location>
            <begin position="24"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="453"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="508"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAG5075958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="508" mass="58384" checksum="BCD5339CD46C653B" modified="2022-05-25" version="1" fragment="single">MSVVLLAIIIVLLSYLIWNFVAGKPKNSPPGIIRLPLWGSYWFLLWGNYYFPHQTVAYYVKKLKSKIIGCYFGDAYTVIVNDYASVKEVLTRKEFDGRLGDNYILRARANGKKLGMFFNDDYEWKQQRRFALHNMRNLGFGRRHAQLETVLAEELDVLVDTIKNGPINDKEKQVVDKDRVLFPDILSPISANYIWAVMANKRLPRTETGEEHESLRELCKWARTFQAGGDTSGGAISLTPWLRYFGNLFGYTDFINGNQAIINFVKLSEETNDAFIPTYLREMKKIHKKAGDNSEDIDAKMFSTEQLVMICTDFMFPALSAVPAVATNCIKYMVHYPEVMKRVQEEIGSVVGSNRLPVWDDRTRLPFTEAVIREVMRIETVTPLSVGHRCTETTQFFEYTIPEDTLMLTNLAAMHNDPDLWGDPENFRPDRFVEDGKIVKDLTLPFGLGRRVCAGETFARFIIFELFTTLVQNLDFERLEGQPTSLQDKIPGLIVQPKSLWIKFKARQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H5E3</accession>
    <name>A0A8J2H5E3_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase</fullName>
            <ecNumber evidence="5">2.4.1.143</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="21">Beta-1,2-N-acetylglucosaminyltransferase II</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="20">GlcNAc-T II</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="19">Mannoside acetylglucosaminyltransferase 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase II</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="28" type="ORF">HICCMSTLAB_LOCUS1780</name>
    </gene>
    <organism evidence="28 29">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="28" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>an N(4)-{beta-D-GlcNAc-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = N(4)-{beta-D-GlcNAc-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[beta-D-GlcNAc-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12941"/>
            <dbReference type="Rhea" id="RHEA-COMP:13526"/>
            <dbReference type="Rhea" id="RHEA-COMP:14369"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:60615"/>
            <dbReference type="ChEBI" id="CHEBI:60651"/>
            <dbReference type="EC" id="2.4.1.143"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 24">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Golgi apparatus membrane</location>
            <topology evidence="2">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the glycosyltransferase 16 (GT16) protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="28">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.143" evidence="5"/>
    <dbReference type="EMBL" id="CAJNRD030001116">
        <property type="protein sequence ID" value="CAG5075628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H5E3"/>
    <dbReference type="OrthoDB" id="6019616at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005795">
        <property type="term" value="C:Golgi stack"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008455">
        <property type="term" value="F:alpha-1,6-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009312">
        <property type="term" value="P:oligosaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007754">
        <property type="entry name" value="GlcNAc_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12871:SF0">
        <property type="entry name" value="ALPHA-1,6-MANNOSYL-GLYCOPROTEIN 2-BETA-N-ACETYLGLUCOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12871">
        <property type="entry name" value="BETA-1,2-N-ACETYLGLUCOSAMINYLTRANSFERASE II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05060">
        <property type="entry name" value="MGAT2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15 25" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="16" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="13" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="17 24" id="KW-0464">Manganese</keyword>
    <keyword evidence="14 27" id="KW-0472">Membrane</keyword>
    <keyword evidence="10 24" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="29" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 27" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 27" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="27">
        <location>
            <begin position="66"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="26">
        <location>
            <begin position="372"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="26">
        <location>
            <begin position="395"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="binding site" evidence="23">
        <location>
            <begin position="168"/>
            <end position="172"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="23">
        <location>
            <position position="199"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="23">
        <location>
            <begin position="274"/>
            <end position="278"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="24">
        <location>
            <position position="306"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="23">
        <location>
            <position position="351"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="24">
        <location>
            <position position="502"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="25">
        <location>
            <begin position="241"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="25">
        <location>
            <begin position="328"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="25">
        <location>
            <begin position="450"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="25">
        <location>
            <begin position="455"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="25">
        <location>
            <begin position="506"/>
            <end position="515"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00014817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00029663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00031203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00032552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00032915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00093257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="PIRSR" id="PIRSR607754-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="PIRSR" id="PIRSR607754-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="PIRSR" id="PIRSR607754-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="EMBL" id="CAG5075628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="581" mass="65925" checksum="645D3DF86B786BAF" modified="2022-05-25" version="1">MIFSVTEITIRNASMRGIPNDSLVERGLVKPYSVSSIYTRKKNGIIRGVTIAGGARSGRGTIIRTLIFVFLATFLWLQLHVISLTGRNSSGQSSINESIYALVPQELQRFLKDRRNSSQTNGTLGIYGTSFDIGDIKTTIAKLNSEQKIYNDDIFGPLGTDAPIIVIQVHSRLTYLRHLIVSLAQAKEIEDVLLIFSHDVWNPDINYLIQSVDFCRVMQIFYPYSIQTHPNTFPGEDPNDCPRNIDKKQAQALKCINAQHPDLYGHYREAKFTQTKHHWWWKANRVFDQLNVTRNHTGMVLFLEEDHYVAEDFLHVLKLMERTCKHSCERCNVLSLGTYLKTYNYYADLSRKYLSVNSGLQKEVLRGLDRHDDVVNDPDVTTQQHKGPGKKKSLQEGQQNKPSSTSSWSFQLLPTLYSHYQKAEVIPWISSKHNMGMAFNRVTWNKLRKCASQFCSYDDYNWDWSLQYVAQTCLPPSRGAGAAPRVDSGLVAMMMRAPRVFHIGECGIHHKKNNCESTAVIAKVQQVLKSARNHLFPSQLTLTIAGVAKKTKLRKGNGGWGDLRDHHLCGNITANPDLVLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H5P4</accession>
    <name>A0A8J2H5P4_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS1402</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001116">
        <property type="protein sequence ID" value="CAG5075248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H5P4"/>
    <dbReference type="OrthoDB" id="1046782at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051057">
        <property type="entry name" value="PI-PLC_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13593">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13593:SF113">
        <property type="entry name" value="SI:DKEY-266F7.9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26146">
        <property type="entry name" value="PI-PLC_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5075248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="279" mass="33263" checksum="BFE4639668DEA491" modified="2022-05-25" version="1">MDIRTQDLSIADQLTYGVRMLEITVRLENGKLEIYSSGIALNKTLFNALVEIEQFLHFHSRELVILVINYDDHYFLDWLDGILTKLDLCMAIDEYNHVIAGWRLVKNWDLDETIDKYRGKILLATNDFLFEDCIHSIRHECLTSKDIVLSDTYAFSDTISQKWNRYFKLNQNCYFFTSFCFFYDMSFDVLDQYAYVKKGYNRRDVTAFGYYDNVENKCYKPLNYIFINNDIPDCIFKLNIFNFEFITMEIIDHVDKMNADVRHSHSINIHLQHSYVYNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H6Q4</accession>
    <name>A0A8J2H6Q4_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Homeobox protein cut-like</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">HICCMSTLAB_LOCUS2875</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the CUT homeobox family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001117">
        <property type="protein sequence ID" value="CAG5078907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10257567at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048468">
        <property type="term" value="P:cell development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048699">
        <property type="term" value="P:generation of neurons"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.260.40:FF:000004">
        <property type="entry name" value="Cut-like homeobox 1a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.260.40:FF:000010">
        <property type="entry name" value="Cut-like homeobox 1a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000298">
        <property type="entry name" value="Homeobox protein cut-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.260.40:FF:000027">
        <property type="entry name" value="Homeobox protein cut-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="entry name" value="lambda repressor-like DNA-binding domains"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003350">
        <property type="entry name" value="CUT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14043">
        <property type="entry name" value="CCAAT DISPLACEMENT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14043:SF2">
        <property type="entry name" value="HOMEOBOX PROTEIN CUT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02376">
        <property type="entry name" value="CUT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01109">
        <property type="entry name" value="CUT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="lambda repressor-like DNA-binding domains"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51042">
        <property type="entry name" value="CUT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7 11 12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8 11 12" id="KW-0371">Homeobox</keyword>
    <keyword evidence="10 11 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="9 13" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 13" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="CUT" evidence="17">
        <location>
            <begin position="430"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="domain" description="CUT" evidence="17">
        <location>
            <begin position="845"/>
            <end position="932"/>
        </location>
    </feature>
    <feature type="domain" description="CUT" evidence="17">
        <location>
            <begin position="1052"/>
            <end position="1139"/>
        </location>
    </feature>
    <feature type="domain" description="Homeobox" evidence="16">
        <location>
            <begin position="1179"/>
            <end position="1239"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="11">
        <location>
            <begin position="1181"/>
            <end position="1240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="135"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="262"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="550"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="714"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="970"/>
            <end position="1006"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1138"/>
            <end position="1186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1236"/>
            <end position="1258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1313"/>
            <end position="1383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1402"/>
            <end position="1483"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="40"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="15">
        <location>
            <begin position="162"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="173"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="262"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="320"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="558"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="581"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="720"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="746"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="970"/>
            <end position="984"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="15">
        <location>
            <begin position="990"/>
            <end position="1004"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="1323"/>
            <end position="1332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="1402"/>
            <end position="1414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="1465"/>
            <end position="1483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU361129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="CAG5078907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="1483" mass="162738" checksum="D35C765ABB9122EC" modified="2022-05-25" version="1">MGIIGENNSRDRLPHRLLLTPDAPPPPLVEFAHGTVNAFINQLVEEVTRLQQNLQRLQETTAAATARLEEELESRRQHINRLEAKLERQRDYDDLKREISVLRSVDLSQIPTGEPGKSLEHLLMERNKALQQAESLKSSTPDTVGGLASPLHRASTASPHIGGVGISVGGGRSTTPAHPSASRLTPTPTGAQNLLFPPPLQNVETFGSFLGEEIVANWRRSLERSIMSQQSSTGQSVAVQSLSIQQNSATGAIATSQVNAAIQSSNHPSPSTDPVSASTTSVTNPPPAKSVTPISSCVDASEKAPTPIPGHETPAPPTPTSTGALTSPSAAPISQEAPNPVSFSVNGSLIGPKSPDECHNNNNSHHLTNNNIGLSVLDSLKSPFRFDDRNHPFRFGDEFGAAGMAGRLGESLIPKGDPMEARLQEMLRYNMDKYASQNLDTLHIARRVRELLSIHNIGQRLFAKYVLGLSQGTVSELLSKPKPWDKLTEKGRDSYRKMHGWACDENAVLLLKSLIPKKGKEQGIPPFARATTEGPDISDDRIAHMFNESSQHLQQLSREPETSNDADSKSPSRLGCPSPFGKDRYDSQNRRIKKYENDDIPQEKVVRIYQEELAKLMGRRVDDIRPRDFPPTAQNLGMERSQDDIRMALDAYHRELQKLNAPGQNPALTGIPGLPSLPGLLALHQQALHQNHLSANGAGVQDLSLGKVDARGKLMNGVSEEDKEKMEEAMRHAGSAFSLVRPKQEPGTQSTPGGSSASSPLGNSILPPAMTPSEEFAGTAAASPLQRMASITNSLISQPSTQTHHSANQRPLKAVLPPITQQQFDLYNNLNTEDIVKRVRKYVSLCLLLVLTHHSKLMFVLQVKEQLSQYSISQRLFGESVLGLSQGSVSDLLARPKPWHMLTQKGREPFIRMKMFLEDEQAVHKLVASQYKIAPEKLMRTGGYGGLPPCGTPMKPMPPTKLVQEQLQNAAKAQAAAQAAAQAQHELQLGPPPTQPPQPPPPMMMTPTHHPHVQLTMELQKKQAQQQMGLHSPHQMTSPLRSLHPHISPSVYEMAALTQDLDTQTITTKIKEALLANNIGQKIFGEAVLGLSQGSVSELLSKPKPWHMLSIKGREPFIRMQLWLSDAHNVDRLQALKNERREANKRRRSSGPGHDNSSDTSSNDTAEFYHAASPGPGPPSAKKQRVLFSEEQKEALRLAFALDPYPNVATIEFLASELALSSRTITNWFHNHRMRLKQQTPHGQPEPQSPREPGQPFDPVQFRLLLNQRLLEIQKERLGLGNMPIPYSPYFNPNLATLMTNALKEQCSGLDLSMGSLKREPNPEYEDDDGDDMSNVGSEDSDASGGSIKREPDLNQQTSAPAGRSSRRKPAAPQWVNPEWQEPARTGDEVIINGVCVMKTDDYGVKREAEETVRVEPTPVSDRYDDDAASEASSVSNAPERDVPTPSPSLKSQGQASPPPSPRPEGIESPKEVKHEPDETWDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H6W6</accession>
    <name>A0A8J2H6W6_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Similar to SHROOM2: Protein Shroom2 (Homo sapiens)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HICCMSTLAB_LOCUS3115</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the shroom family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5080836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H6W6"/>
    <dbReference type="OrthoDB" id="10063560at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005912">
        <property type="term" value="C:adherens junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043296">
        <property type="term" value="C:apical junction complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016324">
        <property type="term" value="C:apical plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030864">
        <property type="term" value="C:cortical actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000902">
        <property type="term" value="P:cell morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.3120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014799">
        <property type="entry name" value="ASD2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027685">
        <property type="entry name" value="Shroom_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15012">
        <property type="entry name" value="APICAL PROTEIN/SHROOM-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15012:SF32">
        <property type="entry name" value="PROTEIN SHROOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08687">
        <property type="entry name" value="ASD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51307">
        <property type="entry name" value="ASD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ASD2" evidence="7">
        <location>
            <begin position="378"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="116"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="268"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="429"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="518"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="23"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="133"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="183"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="198"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="224"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="242"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="272"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="449"/>
            <end position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG5080836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="693" mass="76870" checksum="318ABD62C811FFCF" modified="2022-05-25" version="1">MGKLSHELSKKLQASDTRPRSESNNNINNNHNNNNHDNNSSNNNNNNSNNNNNNNNNIKRDLKERVSPQSVQVLNDRNRQLERERRIEDFYRERSATIEMTSRNVELLNRRNILTEKRHSTTGTTTDLDHENSLSSTSTSTSTSTSTSSSPFTDKSPPTTSPRFAKMHKNEEGQLRSRGAVPRRSGSCSSSSSSRSSLEQGLTHSRSSPAKIYSNNLQNREHRKSLPELENVKESYPAPRSKVSSPAQTESSWIKLGSSQTDTLFTSRLRRSPSSGSRSSSLSSASKISSSSSSLSPRYSPIEGKSSSPCVSPQPGIEGLTLMQRTEVILRVNTTTMDVASQTEALDEEEPAKEVTENTLIAEPRRKLPEEIECEKLSRDLASQLGPNDKLVTILVPVPELKKPTDYMSGLFRVETTLQPRPRRLVSIEPSLISTATENGSEDRKNEMPSTPNNGTNNTTSTNNNNTTEPSSPVSPTSTYLMTSEGKARFLTQYSQDIGDVKVTNGDTPPNSDSDNLKQKKEELVMRLDRKVVVLKAEQEAVKEEGEMNETLGAKIASRVAAVAQSAEASKYKLHVEEVGMITNLLVVLSGRLARAENALHGMPANHSERKILEAKRDQLLEQLHDAKVLKINIDKRSVNVSAILSKYLNNEEFADYQHFITMKTKLIMDGREIQDKVKLGEEQLAALKEAIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H6Z1</accession>
    <name>A0A8J2H6Z1_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Similar to NPEPPS: Puromycin-sensitive aminopeptidase (Homo sapiens)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HICCMSTLAB_LOCUS3160</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase M1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5080980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H6Z1"/>
    <dbReference type="OrthoDB" id="510539at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042277">
        <property type="term" value="F:peptide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043171">
        <property type="term" value="P:peptide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="entry name" value="Neutral Protease Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1730">
        <property type="entry name" value="tricorn interacting facor f3 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045357">
        <property type="entry name" value="Aminopeptidase_N-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042097">
        <property type="entry name" value="Aminopeptidase_N-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001930">
        <property type="entry name" value="Peptidase_M1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050344">
        <property type="entry name" value="Peptidase_M1_aminopeptidases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014782">
        <property type="entry name" value="Peptidase_M1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11533">
        <property type="entry name" value="PROTEASE M1 ZINC METALLOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11533:SF294">
        <property type="entry name" value="THYROTROPIN-RELEASING HORMONE-DEGRADING ECTOENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01433">
        <property type="entry name" value="Peptidase_M1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17900">
        <property type="entry name" value="Peptidase_M1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00756">
        <property type="entry name" value="ALADIPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63737">
        <property type="entry name" value="Leukotriene A4 hydrolase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Aminopeptidase N-like N-terminal" evidence="12">
        <location>
            <begin position="11"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M1 membrane alanine aminopeptidase" evidence="11">
        <location>
            <begin position="179"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF17900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAG5080980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="407" mass="47689" checksum="BF878533569ACBF0" modified="2022-05-25" version="1">MDERYTKVISNQNGHIYDVTGQWWYPLNDHYIIELKEELKTGNYTLLLRWNNDFSENKKIFRNKNKNYFFIGTKNLRLSTARNLFPCWDEPIFRANFEISIEHPKNFTALSNMPIERNFTTPKDNYLTYFQKTPLLSPHSISFAITNYPVIAAKLKTLSMYSIKQDQVSFLSYAINLNSILRALLDYMGISYPLPKIDSVIISGNEDGCISNPGLIFYRSYEYLTTSKSPLVIYRNQEFGDLKAITAITLQWFTDLVTPNDSNYFWLYNGIGHNLAAKIHDQIHPKLRRREMQTLELYNYLLDPEFKKPSSISLLSIGNQTYVSENVKQYVRGASIIQMLEYVVFKPEFYQNGLLRQYLSKNLFKTTTLEDLWTSLENARKNNSRMSLIKCKSNGELLNQAIWLSYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H7D5</accession>
    <name>A0A8J2H7D5_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS2826</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001117">
        <property type="protein sequence ID" value="CAG5078743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H7D5"/>
    <dbReference type="OrthoDB" id="6366357at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032062">
        <property type="entry name" value="DUF4803"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47890">
        <property type="entry name" value="LD24308P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47890:SF1">
        <property type="entry name" value="LD24308P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16061">
        <property type="entry name" value="DUF4803"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5078743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="628" mass="71428" checksum="E27D993D1732934D" modified="2022-05-25" version="1">MRLILMFLGLAQALDINSVYNIDELIEFATGAVNNPSEGATELGALEIDGKKNYAEIIESYLITYPHDEDKEEKLLKLKDLVGKIDEAWEQFGQKDLDDNDKSQLGDLPETVNELYSLFVGDYLPVQVAQSKRPFLCEIKIPEQQRLRRVLQAVGLSELRAFILSLKTGEDSQKSLTRTILYLEETILASKFGFKETSDDLRVCDPPEHVRGETFGEFLGLFQGVSLNTGHTNAPAKTGKCPKYCDNINKYQMNKCHTWQDGFNQKIHCPKKECNGRLFGCFSSGTVVYCALGKDSDRRFPWVQAAYKRWGNPSSECNGTQEKLSDIDTYFLKCSMCLCICSEEDEGSSATRTISLVPQFADIQNNMVVTGVRFQQQDNIFHVQIEESKLEAHMEIDPSSSKWKKFNSFKYNARKGTYSMKKGKTKVELFEEFDFKFLNWDERSINLDKIKAKKGEVIVGVGLRYNSNEKAVEIQIVSWPVDVKTGELEDPVDLDDEEVEVDWITWENTQSQPKEYQNKRFTISLANLDDPVKASKNPRLSDPNDQVKVQTTGFEKDMAQHTIPYIDLQGVTFPEQKAPLTAIELIYKRAKGFGGFISFKVISYDLIDLLHDGMSQEDIDKYQADFNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H7G9</accession>
    <name>A0A8J2H7G9_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS3301</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5081501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H7G9"/>
    <dbReference type="OrthoDB" id="7676095at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5081501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="373" mass="42030" checksum="E569F2EBF72753F1" modified="2022-05-25" version="1">MAPYRQFNRHPELLDNEISPTIIRSSNHNPPNHLQAPYHFLTGNPRFRFNKNHPLMSSHGNKQHPSVPRGIDDDFNNNRPVNHILIPHGKGITHALSFGKGYVPHDALTGSNFNGASISSQDNYPSQSVSQLPAIANHNNNNHNPYNQNNPNNFDLTAERRLEEIKSLIFKAKQLGLLSDNNNDYNNNEKSIITRDIESFTSQNNYYNNNNNNNNNNDNDKKGIIIRDTILYDDYNKKITELAKNWPTHVFNNNNKNMGIINVAELAAQNGFNIPAQFLRHINLHNGGIGSNNLLKQNSGYAVNEHVQDIPQDYNRYKPIAELRPNPTPVATAAAIVATGAQVVPQVPQGHNQQNSHLHPGYFSLHSPTIFHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H7I7</accession>
    <name>A0A8J2H7I7_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Muscle (Schistocerca gregaria)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HICCMSTLAB_LOCUS3333</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5081606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H7I7"/>
    <dbReference type="OrthoDB" id="354351at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012674">
        <property type="entry name" value="Calycin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000463">
        <property type="entry name" value="Fatty_acid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031259">
        <property type="entry name" value="ILBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000566">
        <property type="entry name" value="Lipocln_cytosolic_FA-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11955">
        <property type="entry name" value="FATTY ACID BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00061">
        <property type="entry name" value="Lipocalin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00178">
        <property type="entry name" value="FATTYACIDBP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50814">
        <property type="entry name" value="Lipocalins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lipocalin/cytosolic fatty-acid binding" evidence="3">
        <location>
            <begin position="6"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG5081606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="101" mass="11379" checksum="72489EC158974BF9" modified="2022-05-25" version="1">MGASVSPVVELTKDDNDLYTLKTTSTFKTSEVKFKLGEEFDEETPDGRKVKSVITLDGNKMSHIQKGEKDTVIEREFTPTEMTAIMKVDDIVCTRVYKLQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H7S0</accession>
    <name>A0A8J2H7S0_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Emp-scavenger receptor class B member 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HICCMSTLAB_LOCUS3469</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CD36 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5082150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H7S0"/>
    <dbReference type="OrthoDB" id="18585at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005044">
        <property type="term" value="F:scavenger receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002159">
        <property type="entry name" value="CD36_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11923:SF88">
        <property type="entry name" value="DEBRIS BUSTER, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11923">
        <property type="entry name" value="SCAVENGER RECEPTOR CLASS B TYPE-1 SR-B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01130">
        <property type="entry name" value="CD36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01609">
        <property type="entry name" value="CD36FAMILY"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0675">Receptor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="64"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="487"/>
            <end position="514"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAG5082150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="576" mass="65029" checksum="79AA5DBB5D6E617C" modified="2022-05-25" version="1">MKFITSLFGVGSPKKMGRQYMKVGRNALFGIRPNREGEPMCAERVPRPMNVFISKKGKLRHGRIAAILFGLLALAIGIILSSIPWVDYVILRQLRLWNGSLSFQYWQKPGVVRLTKVYIFNVTNADTFLSLNEKPKLQEVGPFVYREDMEKVNIVFHNNGTVSYQHKKILNFVPELSKDKDLRVLVPNIPLLTLTTQSKSLPRFLNFGLSMFISGLNQKPFVPVTAQQLVFGYDDPLVSIAHRFFPKARRPMHQMGLLLARNGTLDEVSTIYTGHTDMKQFGLINKLNGLDRLPYWEDEPCNSITASEGSFFPPRDSTGADVVHVWDKDLCRVLPLQYRGPVEKAGINADLYTPTDDVFDPPSVKKPDNECFCPDDPTSCPLKGLQNISPCQYSAPVYLSFPHFYKADQKLTDTVVGLKPVPELHETYFKIQPKLGVPVEGKVRVQLNLKVERQSDITAVKDFPDIVFPIMWIEEGIDELTPAIRRWIYLATTFADIAVPCITYGLILVGMVVLSTITIKAYTNVLTTQEAIELGKKTIRRGSSFIVNGQHRTLVVKDSYILLSHNSEDARPIVEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H7Z8</accession>
    <name>A0A8J2H7Z8_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Similar to CERS6: Ceramide synthase 6 (Homo sapiens)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">HICCMSTLAB_LOCUS3589</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>sphinganine + octadecanoyl-CoA = N-(octadecanoyl)-sphinganine + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:36547"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57394"/>
            <dbReference type="ChEBI" id="CHEBI:57817"/>
            <dbReference type="ChEBI" id="CHEBI:67033"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:36548"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism; sphingolipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Sphingolipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5082536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H7Z8"/>
    <dbReference type="OrthoDB" id="537032at2759"/>
    <dbReference type="UniPathway" id="UPA00222"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050291">
        <property type="term" value="F:sphingosine N-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046513">
        <property type="term" value="P:ceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000020">
        <property type="entry name" value="Ceramide synthase 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016439">
        <property type="entry name" value="Lag1/Lac1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006634">
        <property type="entry name" value="TLC-dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12560:SF0">
        <property type="entry name" value="LD18904P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12560">
        <property type="entry name" value="LONGEVITY ASSURANCE FACTOR 1 LAG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03798">
        <property type="entry name" value="TRAM_LAG1_CLN8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005225">
        <property type="entry name" value="LAG1_LAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00724">
        <property type="entry name" value="TLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50922">
        <property type="entry name" value="TLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10 12 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 12 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="139"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="179"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="260"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="302"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="domain" description="TLC" evidence="15">
        <location>
            <begin position="130"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="341"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="341"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CAG5082536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="370" mass="43461" checksum="B9D3E6B62802380D" modified="2022-05-25" version="1">MEILKNISSSFWSPDIWLPPNITWDDINPNSENKYADSHHLLYPLPMALGLLVVRYCLERFCFAPFGKSLGIKTSRTKKATPNALLEKAYSKKIKHKQITALAKQLDWSERQVERWLRLRRSQDKPSTLTKFCENCFRCLYYSLIFIYGLVVLWDKPWLWDIKNCYYGYPYHAVTDDIWWYYMISISFYCSLSISQFFDVKRKDFWQMFIHHKATIILMSFSWVGNLTRIGSLVLLVHDCADIFLEAAKMAKYANYQKTCDAIFGIFTILWLITRMVIYPLWIIYSTSISAPKIVPMFPAYYIFNSLLILLFVLHTFWTYLILKIAYNAFNAGQMEGDIRSSSSEEVSDDNLANDQPNNSSNHLKSEKQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H862</accession>
    <name>A0A8J2H862_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS3708</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5083016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H862"/>
    <dbReference type="OrthoDB" id="7693009at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035302953" evidence="1">
        <location>
            <begin position="22"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5083016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="172" mass="19299" checksum="7749B01BAA5DD999" modified="2022-05-25" version="1">MKISAELWSFLAAILATLTFADKTPDLKINTLTINNTPDNPYFGNWSFEISESGDRFSLLFPIKQDYPENMMFGLAAELNGRQVLSMEMSVCDGLEAGLANQRMLDHVYPPDTVQLSCPVKAADYELRDYSFSADNSPFQLEAGELFVKLFYFEPDGEPILTITMEGLISDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H864</accession>
    <name>A0A8J2H864_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Branched-chain-amino-acid aminotransferase</fullName>
            <ecNumber evidence="11">2.6.1.42</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HICCMSTLAB_LOCUS3007</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-isoleucine + 2-oxoglutarate = (S)-3-methyl-2-oxopentanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:24801"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:35146"/>
            <dbReference type="ChEBI" id="CHEBI:58045"/>
            <dbReference type="EC" id="2.6.1.42"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-leucine + 2-oxoglutarate = 4-methyl-2-oxopentanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:18321"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:17865"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57427"/>
            <dbReference type="EC" id="2.6.1.42"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-valine + 2-oxoglutarate = 3-methyl-2-oxobutanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:24813"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57762"/>
            <dbReference type="EC" id="2.6.1.42"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.42" evidence="11"/>
    <dbReference type="EMBL" id="CAJNRD030001117">
        <property type="protein sequence ID" value="CAG5079422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H864"/>
    <dbReference type="OrthoDB" id="1732691at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004084">
        <property type="term" value="F:branched-chain-amino-acid transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:L-leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:L-valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01557">
        <property type="entry name" value="BCAT_beta_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.10.10:FF:000004">
        <property type="entry name" value="Branched-chain-amino-acid aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.10:FF:000002">
        <property type="entry name" value="Branched-chain-amino-acid aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.10.10">
        <property type="entry name" value="D-amino Acid Aminotransferase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001544">
        <property type="entry name" value="Aminotrans_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018300">
        <property type="entry name" value="Aminotrans_IV_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036038">
        <property type="entry name" value="Aminotransferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005786">
        <property type="entry name" value="B_amino_transII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043132">
        <property type="entry name" value="BCAT-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043131">
        <property type="entry name" value="BCAT-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033939">
        <property type="entry name" value="BCAT_family"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01123">
        <property type="entry name" value="ilvE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009897">
        <property type="entry name" value="PRK13357.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11825:SF44">
        <property type="entry name" value="BRANCHED-CHAIN-AMINO-ACID AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11825">
        <property type="entry name" value="SUBGROUP IIII AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01063">
        <property type="entry name" value="Aminotran_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006468">
        <property type="entry name" value="BCAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56752">
        <property type="entry name" value="D-aminoacid aminotransferase-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00770">
        <property type="entry name" value="AA_TRANSFER_CLASS_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 11" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="3 11 12" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="7 11" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="6 10" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0808">Transferase</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="8">
        <location>
            <position position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR006468-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAG5079422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="399" mass="45330" checksum="5994F5C952C1621D" modified="2022-05-25" version="1">MFVVQEVFFFCVLVSIWNIRGQYLVRNGQYSEKLAYADLSVRLAPPHLLQPKPDVRDLVFGKYFTDHMFKVFFHEDLGGWQAPEITPLESLVLHPASKALHYAVQAFEGMKAYRGKDDKIRLFRPELNMQRLNHSAKRLGLPSFNSTQFIKCLSRLISIDQEWVPHCETASLYIRPTVIGVDPTLGVATSRSALLYAILCPVGSYFHGQVSKGVSLLADPSYTRAWPGGCGDSKLGSNYAPTIHIQEKAEEKGLQQVLWLYGEDMQLTEVGTMNIFMFIINEEGEKELITPPLNGLILPGITRMSILNLAHEWNQFKVIERIITMEEVCRLTSEKRILEMFGAGTACVVSPISNIHFLNQFLHIPTMEQPSPLYDMILKSLLNIQYGYVPNHPWIIKVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H8A0</accession>
    <name>A0A8J2H8A0_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS3785</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5083265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H8A0"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5083265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="128" mass="14837" checksum="B01C344F149A5603" modified="2022-05-25" version="1">MEDLNEVIPKNNLVEKEPCNCGDTRCLSKEENPIDALEVDIKCLFGNILDIQRGVKNQIDSIKKVMKEVTDDEFNKLQYYWANAKFDSGCASAHLYLALKRIGNCDKAQTILKYNQENEIFQKYLLWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H8Q1</accession>
    <name>A0A8J2H8Q1_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Gustatory receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HICCMSTLAB_LOCUS4345</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Cell membrane</location>
            <topology evidence="1 8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the insect chemoreceptor superfamily. Gustatory receptor (GR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5085329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H8Q1"/>
    <dbReference type="OrthoDB" id="6366728at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030425">
        <property type="term" value="C:dendrite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043025">
        <property type="term" value="C:neuronal cell body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007635">
        <property type="term" value="P:chemosensory behavior"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008049">
        <property type="term" value="P:male courtship behavior"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050909">
        <property type="term" value="P:sensory perception of taste"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013604">
        <property type="entry name" value="7TM_chemorcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21143:SF133">
        <property type="entry name" value="GUSTATORY AND PHEROMONE RECEPTOR 32A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21143">
        <property type="entry name" value="INVERTEBRATE GUSTATORY RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08395">
        <property type="entry name" value="7tm_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 8 9" id="KW-0675">Receptor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="50"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="82"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="137"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="164"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="252"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="359"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAG5085329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="393" mass="45582" checksum="0E9EB81B05228F4E" modified="2022-05-25" version="1">MKNLNFLNSKESSISFIVTFFKIFGLAPFEVVFSKSVPQIFLRSSTQNRIYTFLLSIPCVALLVRIVMNFSTITPKLVLRKLVTINLSWISTVILWYYCFNHQKIIRILNDLLDLEQDLVNQFNRSVSRRESRNYEIASFISEVVLMILQVIPFIFEAVASDDWWAVVMVTSGFIINIFMLQHTILVHFINKRLNFTNELLLSLIKNDNCSDLIFVKSATHNELILRTIILLKQHQRKLLVIFKDLSDFFEWPILLTIIIFCIRLILYSYKFAKRVIFFSHKIPLISFICEPATMVKEIFIIVIFTNQMTQITSETKKTGEVIFEVMDAYSTHGGIQSQLKQFSIEVLHRKIPDSIFGLFKINGGLVTAITASVITYLVILIQFNYNLDIVDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H8V4</accession>
    <name>A0A8J2H8V4_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Similar to His1: Histone H1 (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HICCMSTLAB_LOCUS4515</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Histones H1 are necessary for the condensation of nucleosome chains into higher-order structures.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the histone H1/H5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5087445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H8V4"/>
    <dbReference type="OrthoDB" id="10070184at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031492">
        <property type="term" value="F:nucleosomal DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030261">
        <property type="term" value="P:chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045910">
        <property type="term" value="P:negative regulation of DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006334">
        <property type="term" value="P:nucleosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00073">
        <property type="entry name" value="H15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000140">
        <property type="entry name" value="Histone H1.0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005819">
        <property type="entry name" value="H1/H5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005818">
        <property type="entry name" value="Histone_H1/H5_H15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11467:SF20">
        <property type="entry name" value="H15 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11467">
        <property type="entry name" value="HISTONE H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00538">
        <property type="entry name" value="Linker_histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00624">
        <property type="entry name" value="HISTONEH5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00526">
        <property type="entry name" value="H15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51504">
        <property type="entry name" value="H15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0158">Chromosome</keyword>
    <keyword evidence="5 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="H15" evidence="9">
        <location>
            <begin position="92"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="168"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="244"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="249"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAG5087445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="271" mass="29526" checksum="EE2FB3AC0E840510" modified="2022-05-25" version="1">MKMYIVRPRQSTDIQRSTSTWWVLYVRDVFEGRVVGKRAKAIKAKGSFGFTPLHNTSTIQEIKVVKMTDSLVTMSLGKKPVTKAKKARSKPTHPRTADMVNAAIKSLKDRSGSSLQAIKKYINTTYKVDAEKQAPFIKKYIKAAVESGGLVQTKGKGAAGSFKLSVHGEATKRGGKPASKTTSRPKTPAKTVRKVRTPVKKAVKSPRAVKKVEVVKKTAKPIAAKKKTVKGPAAKLSKVKVNSPAKTVNKVKKSPVKAKAAKKVKKVVKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H9J2</accession>
    <name>A0A8J2H9J2_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Similar to TBC1D16: TBC1 domain family member 16 (Homo sapiens)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HICCMSTLAB_LOCUS4442</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5087191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H9J2"/>
    <dbReference type="OrthoDB" id="10264062at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.270:FF:000017">
        <property type="entry name" value="TBC1 domain family member 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.80:FF:000020">
        <property type="entry name" value="TBC1 domain family, member 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22957:SF547">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22957">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="3">
        <location>
            <begin position="304"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="118"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="121"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG5087191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="616" mass="70281" checksum="E6662BFF0A0DC2C3" modified="2022-05-25" version="1">MIYQDGEALFCKNNVCVHPPSLMRQHCEVIHHPGYMTVVCKLDKNTNLPSLQLSWIPNSTLCKHPTTLENITAKKIQGKIQLTEDSTNSDKIDVCLEVKEPLDCKDCERICSGGTNTTQFSKEDSADGEKPTKESKALTEEPRSINLSNLRSRSVDHESLIDGINGIEPKSISSISLNSCCSLSNSLDNQDVPNWMRTPELLALQHNLTFPESTTASPIAMRRALQCRRFSVDLSQMRSLRLFFADPACTSGQLVVASRETRDELHPEEGQVPMITSLTWKDLLNERGQVEDDLSLRKGIFFGGLEPALRKIVWPFLLHCYSYQSTFEDREQIDEIRRQEYAEIEKIRSSMNPEQAELFWRNVVCIVEKDVVRTDRANPYYAGENNPNIQVMKNILLNYAVYNAQLGYTQGMSDLLAPLLAELNSEIDAFWCFAGLMQRSVAVCTPTDTDMDKNLCYLRELIRIIVPDFYAHLEKHTDALELLFCHRWILLCLKREFPTEMALIMWEACWVNYLTDYFHLFLCLAIICIYADDVIAQDLRTDEMLLHFSSLAMYMDGNVILRKARGLLYQFRQLDRLPCTLAGLCRQCGPVAGATRPEIQGIQIIKMSKRESTRNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H9R7</accession>
    <name>A0A8J2H9R7_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to ORF1: Nucleic-acid-binding protein from transposon X-element (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS4787</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5088283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H9R7"/>
    <dbReference type="OrthoDB" id="7989680at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33273">
        <property type="entry name" value="DOMAIN-CONTAINING PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33273:SF4">
        <property type="entry name" value="ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14529">
        <property type="entry name" value="Exo_endo_phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="2">
        <location>
            <begin position="438"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5088283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="851" mass="97590" checksum="12F2894DFE3A07DF" modified="2022-05-25" version="1">MNIETDKKNTRKAKSTKRNAKGESKDNNANPTSDKAAPKTAKTRPPPIYANITGIKTVITFLTSNGIAANEFTVKEFDESYSKVIPNNMDAYTLYKKQLEKQKIQYFTYTPRHLKVKTVALKGVRGGYDEIDVKNALIAFNLPNTTITKVSKLIFDKTKPHLYHFLVSASADSNLAMLMRQKTLLSQIIRWERLKRPALFMCTRCQQTGHSSANCNMEPACAKCAGPHETKTCTVVTATDKTAQKCINCGEKDHPASYKGCPALKLVAKVRLNKRKIDEARRKKIMESINNYVTPTQSFANITDNTSSRHFPSLPKARPTAAGVNFNMQNPRTEPASTTTRQNLGNDTSHLENLLISFKNDIVKEFKKLNEKVNSNSSRIDQIMAATDRPNSTKGGGTAIAIHNKLKFTTIHYPHSLKNKVIEYTAIKIKISNKANLIIISIYATQKYGQTFINELNKLMREFKLDNASNYYLIAGDFNTKHISWGDVDSNNRGDQLVDWLEANYLQYKISMIPPSTPTFHNAKIKSYLDHCLIDMRIDVEDLINGKLITLPYDSDHWAISLTIFIEVESTDFTHNQDSNRKALNYKKANWNKFGRNLLDNYTDECSVPYDRNLSIEEIDNHIIELENKIVNSIQATVPTIKKKDDYFIKYSNRKINKLHAYKSFLIRRKFKNIPVSSQEKIKIKAIIKRINTLIQREFKKTVTAYWEAQVKSINYKKPQDFFPKINRMLRQRKEISINTLKINNDNSQLNSHFMSKFPELVNNNQLIATDADTKLYIIESINAPRYSNLGTINKIDIDKVAEQTKKLKDNMRLLNKSFVEFSNTNRAYYPTNQDDDSRFLFSYIAMYKFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HAC7</accession>
    <name>A0A8J2HAC7_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS5602</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5090363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HAC7"/>
    <dbReference type="OrthoDB" id="10045355at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5090363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="133" mass="15531" checksum="B6CA2FA63224CE96" modified="2022-05-25" version="1">MPESIKIGERLEYKNIDGSNHLVPVNIFAEKIPLAQLLKVFFQSSDILKETLEFMRLLECEINIISTLWKKQRSLFTEKIVFPLFLFFDEFETNNPLGSHKGINKCGAVYINLPNIPPQYKSKLENIFLYYDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HB34</accession>
    <name>A0A8J2HB34_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Centrosomal protein of 162 kDa</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HICCMSTLAB_LOCUS5945</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
            <location evidence="1">Centrosome</location>
            <location evidence="1">Centriole</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CEP162 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5092142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2157184at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005879">
        <property type="term" value="C:axonemal microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005814">
        <property type="term" value="C:centriole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038774">
        <property type="entry name" value="CEP162-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34031">
        <property type="entry name" value="CENTROSOMAL PROTEIN OF 162 KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34031:SF1">
        <property type="entry name" value="CENTROSOMAL PROTEIN OF 162 KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0970">Cilium biogenesis/degradation</keyword>
    <keyword evidence="7 9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5" id="KW-0493">Microtubule</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="137"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="224"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="348"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="391"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="489"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="564"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="978"/>
            <end position="1023"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1087"/>
            <end position="1130"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="671"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="798"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="1044"/>
            <end position="1078"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="1205"/>
            <end position="1239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="147"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="194"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="279"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="391"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="519"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="540"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="997"/>
            <end position="1023"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1095"/>
            <end position="1112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAG5092142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="1319" mass="151735" checksum="19B94C5C194EA79E" modified="2022-05-25" version="1">MTSETKEQINDDDLSKTDETSLSSSISLSIGECSVRLREKPPVVNQPQQNDGKWWVKKPIKVEESKARVSKDATHSSMKEFLEKEKMCRIQNNTSKDKDDTLCDILASTAFDKYPSDFENATDEDIGSFLEEMSKIAGALSPNSAPERTKSTESSKITTEEEKSVEELLEEAEKLVRENVGLSKSASRSDTLVPDEKSRSADDLDRAHNLEDDIFQLIEQEVHREIRKSPRSPKKTSPSPDCEVVYENVNLKPKGLGLQRQRFEEQKVEVSSSSDLDDPIERHSKSEDLKNTKKASQDDQNLRKEITDVDKDFFDDLLRKSKDKAEGKISSSSSFGQEDFSHFLKILQNQDHSDAKPPAESLITCLPNDPKNSTYPEKEITEILERELSKVAKDGKEGGKSSDNSQLSRKSSRDRGIDIKKVINNQNELYSVGLTPRLELFADTIPKLIAEKTDSAFSENSAIPTDKFSSQDLNLQIVSVNLATKSNSVNKIKNPKPEAKGLGPSKSCDQLSRPMKSFRSLDDINSRTDAKKFPPKSKRTSSTTNVSIKPNLTTLASRVKFSVKPVKKPPLKRSDSADGRNSLAGGDSKLNFRKDDWEVLFNEEKHKNMLLRNQIEAEARQYKQQIEGMRVSFEEELFAVKKANIILKAQIDELSLKRIETPVSSKGDTRVLLLKKELEKQESLLKTYEGENKRLMAEAKKFQEEKRVWEKGEKKEVRNLEDETVKLNDIIKDLREEILKFNFEVSDLRQKNSEAAMKNDDLQQQNSLVCEELSMYKEQLKTKDRFISEKLTAWSAEEAESRRRMEEMRIELNSKNEKLKFANEELRRFHEAIGPLEKELLDLRTREQSLLEKIQVSRSHVEREKVLTQKLKDQVILDNKKILDLNRQVREMERILKRKNPDSVSALILTAKSDNERINIEKVRLLEDRIASLEGEIRAKEEYGQEKLTELQKKFVEMKEKYANQVKELEEKIREGSQREKLRRDVSVQVAPSVESRGSEARRDSEEKRERRDSKSGKVGKEDAHLLATIRGLKMELQGKDKMFGKLTREMAELQKMNRKLQKEREKLVNDRKNFKVDERKICSSGVMKGEDHNSNYQNGHVNGKLTGSTSRLYDPSVYSENGEENGGEKRLQEENEFLKEELAKVNKEFLGLKTKRLHDLNLLQDEHDRELAELVKEYSDKFGDSKVVKLQGQISNQGAVIGRLKEQIEELKDYKEQVLVLKVEREHLENKVKVLNEKVKYLSTPGTEQLQLLQEKITILQQRHESREMTLQNLVRELLRSKTQCRDCRGEKGKNRQLCYFRQELDHILAMLQEIANV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HB36</accession>
    <name>A0A8J2HB36_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS6206</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5092537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HB36"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5092537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="95" mass="11134" checksum="6A62E21CB91196D1" modified="2022-05-25" version="1">MTLPKKSVIVDLKEIFKSNQNLYKSVPKIWPYRTAEGLSLSIDLNNDDKLSALHLHLDLNNVCSLLHTWMSIYLCQQRSSMFSQLWEGFWSVLYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HB99</accession>
    <name>A0A8J2HB99_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS6210</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5092541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HB99"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5092541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="83" mass="9365" checksum="D843DCDE43C0FC17" modified="2022-05-25" version="1">MPSIKVICVLNMSRKHLVRSQKVGFPGVAEAIISHTSGHPTFWSWVVYYFSCSPPESTQLRGRGFAKPRRSRDFASRGGQKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HBC0</accession>
    <name>A0A8J2HBC0_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Similar to Rbp6: RNA-binding protein Musashi homolog Rbp6 (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HICCMSTLAB_LOCUS5786</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5090895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HBC0"/>
    <dbReference type="OrthoDB" id="1875751at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48032">
        <property type="entry name" value="RNA-BINDING PROTEIN MUSASHI HOMOLOG RBP6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48032:SF18">
        <property type="entry name" value="RRM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAG5090895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="196" mass="20033" checksum="9ECFE82946F8B64A" modified="2022-05-25" version="1">MFSGFGFVTFQSEDVVDKVCEIHFHEINNKMVECKKAQPKEVMLPANLAKTRAAGRGAYGELVMVATPPTTYRYAPYPLPSAAAVHAHAAAAQATPHHLLAPIVASAATPGSAASYQYAAAAAAAAAAANPTAATVYDVKRALAAAAAAYRPHPAAAAAAAASRAATLTYSMSDLLGVQGLDMGTAVYHPIPTIGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HBX3</accession>
    <name>A0A8J2HBX3_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">O-acyltransferase WSD1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HICCMSTLAB_LOCUS4413</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5087076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HBX3"/>
    <dbReference type="OrthoDB" id="619536at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008374">
        <property type="term" value="F:O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019432">
        <property type="term" value="P:triglyceride biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045034">
        <property type="entry name" value="O-acyltransferase_WSD1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009721">
        <property type="entry name" value="O-acyltransferase_WSD1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31650">
        <property type="entry name" value="O-ACYLTRANSFERASE (WSD1-LIKE) FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31650:SF1">
        <property type="entry name" value="WAX ESTER SYNTHASE_DIACYLGLYCEROL ACYLTRANSFERASE 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06974">
        <property type="entry name" value="WS_DGAT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="315"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="346"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="domain" description="O-acyltransferase WSD1 C-terminal" evidence="3">
        <location>
            <begin position="797"/>
            <end position="941"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="54"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF06974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG5087076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="977" mass="112100" checksum="985F842D20244182" modified="2022-05-25" version="1">MEIKNVSRGDGKETFKAANPNLIKKIHNLRNTVSSLETNFQAANHWDKLRLSRFKNIELSKERLEENLKESEKRNSNMLNLFRYNADLPQGLKTQVQKKWNQKYDALLKLNDHLKRQIREKDSLLQNKDDQIAVLQQKLLDIGEKLSEREELIKTISNKYIKLKKRKTVQETLFKESIETLLRDALLEENHNNTPTTSRMSLKPSKEALLAYETKRSNRLSRENYLLRTILQKIKLNNCHCHEKQSDSIVTSWLTFKLFNHEYTLELLQPINLWSFIWEKIGNASMAYYDLSSIWNGTKPNEANEFNLFENPAKLGVLTGLIIALFIESQYVPAKFDNYIKSKLKNVAFMILNISCFLLTAPVISILLVTFFIYRQIVCLTLKITLGEKFAGLLEGTDCVWAIEDPSALSVINILGVLELNSLSNGINILEEVRALMVIKERLLLFPSFEKLFWKREKKYGYYFWRRSGVNLEERVRLLDVDHSRCKETCNYYREYLREIIAQECNKPLPENHSMGWEILILQNCQKKTFGSERTVSLLFRVHHCVGDGVALLRLLLEAIADSSNSKVKVQLLDDKKIKIKVNQSNLLSIPILRRCSSIYGSLKYSSDVVYYSSDVLSAAMPFAIGIPLYRIFKSFQKYLKVQWELLGCSEAEEMKVKIIKTLKIIRVIIIETLKKLRKVCKNIFKNIMALILIPDCLFRQACLSFDESALHGPELTGNKKISCWIEDTSDSHVSLLEKIRDIKNITDTRFGDVVLAALSANLYKHFHQIGKTAPKKLTIVIPARMSKPNQKLALKNRFSVGLLPLCISEVNGICCEPTNDPRKLLDRLRDVSRSTRKLRTDPDYLINYWVMTWFSAALPEVFLRTFLKSYSTMVFSNLPGPQAVAVLGHTLKKVAFWIPSRGTTGIGCSLLTYNGNVHLSLQADEAVVSEETSLDEILKGTIDDIKALHDIITLPCFAKSFLDTAEAPMETGFGVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HC49</accession>
    <name>A0A8J2HC49_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Similar to BAIAP2: Brain-specific angiogenesis inhibitor 1-associated protein 2 (Cricetulus griseus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HICCMSTLAB_LOCUS6979</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5093644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HC49"/>
    <dbReference type="OrthoDB" id="3800937at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051764">
        <property type="term" value="P:actin crosslink formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051017">
        <property type="term" value="P:actin filament bundle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007009">
        <property type="term" value="P:plasma membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030838">
        <property type="term" value="P:positive regulation of actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11779">
        <property type="entry name" value="SH3_Irsp53_BAIAP2L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000188">
        <property type="entry name" value="Insulin receptor tyrosine kinase substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013606">
        <property type="entry name" value="I-BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027681">
        <property type="entry name" value="IRSp53/IRTKS/Pinkbar"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14206">
        <property type="entry name" value="BRAIN-SPECIFIC ANGIOGENESIS INHIBITOR 1-ASSOCIATED PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14206:SF7">
        <property type="entry name" value="INSULIN RECEPTOR SUBSTRATE 53 KDA, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08397">
        <property type="entry name" value="IMD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51338">
        <property type="entry name" value="IMD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="IMD" evidence="5">
        <location>
            <begin position="1"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="4">
        <location>
            <begin position="280"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="39"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="170"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="346"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="568"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="909"/>
            <end position="931"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="992"/>
            <end position="1079"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="207"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="264"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="346"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="360"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="389"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="416"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="454"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="466"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="528"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="568"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="590"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="648"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="677"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="701"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="719"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="754"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="786"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="796"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1017"/>
            <end position="1028"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1045"/>
            <end position="1067"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAG5093644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="1222" mass="139879" checksum="8F00F158E4B79EFA" modified="2022-05-25" version="1">MREYKNLKAFYVDLLVPLETNLEKDTKVVQSEQKKFLQQHKTRSETYSKAAATMKKQRKKSRGASKSGLAMDKELKNMQILEEEKSKLDAFCEQSLKNAMTQERRRYGFVLERQCSLAKHYASFHEVALAALHPSVDEWREVANTREYLPQSVEDMFASRLRQVSFWPEDEENGGSELTMSSQLRKTRSMDSSCLELRLGPPPSHPPSSLHAGAPSHLSSALSRARSEANLHASSLSLEPDIPETPPRPRSMAPTSRNSVVGSTSGGGGSGTGVNSGVWGESSLARALFAYLSSGENQLSFLEGDLIALMGDRQKGWQFGENLRTQSSGWFPLAYTEIIIDDSLGSPSHAANNGRSPEPRAMPPCKPPPSRPPPTIDDLSNGGIGIGSGNPSSNSNSSNNNNIGNSNTNTSTPTNVPKSHSSHSVATPTGRQPKSIRPSGTLPSLLAAGRRVQPPMPPVPPPQVVTSLHSSNDSGFSNEPPVQPDIDYSDDEAMRQRRRKTRGERLEAAERAMQMMDKQEKLHKHQGHREENEPDDKGKDWLNDSWKTIPRDEKSWQMYRTAMDLWSESKELDKRDLEGPSGRYGPASRRTSDNYEPHHSKEYNSEYEAKDKRDKVSNDPRKSKYAQSRGSIERPSVGNSNNRYMNGNDHRLRDQSNRRSAEGRRSSSREDLSREIEIDESDEENNQEMNQDEAYNEDYEDKNKVEHIAQKLEQTAQKYAREHSPSKFTERRREDYRKSLERDEKLVSSGTNYDKYERDTRVQRFDRERERERERDRERERERYVDNNNKNNQMNYERERTFEKNPDRNKNIERHSNRRFERPKPPFEDAPERPRELPLPRRERRHSDKEEIYGTTGYGVDKFTGSSEVLVEKDRGYESNFETKLERNKVLEKIVYARSDVDNVSRKMIGYSPERNDNNNNTLKSDKKISQRPHTTLGHIVGQSRSFDKEIMSNSPKLIKRTKSFWRFRRDSEVLEGMALWQHRSLVDIPKTLKREQSKTENINNGSSNNEEEINLSRKSSPNSGSRRSPSKESRSSDNTITNEHSNEVREDPKPAERNIVPEKADYYNDFPTPAERPKAVERSEYRISGREERTYFRGISRKAILENERKRSMEAKRNRVVAELKENNDQGMKKSDCNHKGSLYGEDDDGLIQNFTETEASDEESTYSSIILVMNHVIDALTCIAFIVAFTFKGLAPEINFKSFQKHQCLCDGETPENKDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HCD1</accession>
    <name>A0A8J2HCD1_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similar to U-scoloptoxin(01)-Er1a (Ethmostigmus rubripes)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS4743</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5088171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HCD1"/>
    <dbReference type="OrthoDB" id="6428908at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.140.10">
        <property type="entry name" value="Chitin binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002557">
        <property type="entry name" value="Chitin-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036508">
        <property type="entry name" value="Chitin-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052976">
        <property type="entry name" value="Scoloptoxin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22933:SF18">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22933">
        <property type="entry name" value="FI18007P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01607">
        <property type="entry name" value="CBM_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57625">
        <property type="entry name" value="Invertebrate chitin-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50940">
        <property type="entry name" value="CHIT_BIND_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chitin-binding type-2" evidence="1">
        <location>
            <begin position="3"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5088171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="98" mass="11401" checksum="CFEC6BED1C604F36" modified="2022-05-25" version="1">MSAVVVKEYPGFFADVETRCQAWHYCDIDGRQATFLCPNGTQFSQAVLVCDWWFNVRCELSPKLYAINGRLYQRPTESPTRPHRVITKELLENIFAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HCQ4</accession>
    <name>A0A8J2HCQ4_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Similar to resilin: Pro-resilin (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HICCMSTLAB_LOCUS7401</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5094075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HCQ4"/>
    <dbReference type="OrthoDB" id="6595597at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042302">
        <property type="term" value="F:structural constituent of cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031311">
        <property type="entry name" value="CHIT_BIND_RR_consensus"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000618">
        <property type="entry name" value="Insect_cuticle"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051217">
        <property type="entry name" value="Insect_Cuticle_Struc_Prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12236:SF98">
        <property type="entry name" value="CUTICULAR PROTEIN 56F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12236">
        <property type="entry name" value="STRUCTURAL CONTITUENT OF CUTICLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00379">
        <property type="entry name" value="Chitin_bind_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00233">
        <property type="entry name" value="CHIT_BIND_RR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51155">
        <property type="entry name" value="CHIT_BIND_RR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0193">Cuticle</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035265340" evidence="4">
        <location>
            <begin position="18"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="27"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="166"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="30"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="44"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="77"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="173"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAG5094075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="187" mass="19891" checksum="51A683F7904F4C4F" modified="2022-05-25" version="1">MLKLTALTVLLATIVIAKPEPPVLGGQYLPPNQQYGPPQRNNNGFGGNAGPNGGGFGSNQYLPPNQQYGAPGGNSGISGNSGNSGNSGYNDGYSDTPAKYEFEYMVNDIESGNDFGHKESRDGEVTRGVYYVLLPDGRRQTVEYIADENGYRPVVTYMQEGNGAGNGYRNEGPGNGYPTGGNNGYRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HCV9</accession>
    <name>A0A8J2HCV9_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS5493</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5090118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HCV9"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5090118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="375" mass="42690" checksum="487A17E33B129D9A" modified="2022-05-25" version="1">MKSDYHVEVQAFKLLRMSVTFKVSEDRFYKPCVSYNYYYLQRKAYTFLLIFEDDEESLRRMLVNTKGEITTPSDKIFPAEIISKKVELKENLKLQNGIKTSNKRKIDEKIQNQKPILHKFFQVDNQRQFINLSEFKPTVMTSCNPRQASQLQTSFNLIQNSQVLSSFNPVHNSQVLSSLNPIHTSQVLSSLNPVHSSQALSSFNPVHTSQDLSSSISVTTSSPYIFPQEPPFQLPSTSVQESNDYFSVQGSSSSQLNINKSDMYEFPSTVEITPAPLVINMKSLTESTSKENEIISRNVKEGQVIIRDCYNKSASGPTHSGVLKADAAPITLEVVEFVESLAVHLRHQYKKEQDEATSEKTAFRVKYRTLIKKFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HD12</accession>
    <name>A0A8J2HD12_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS5827</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5090979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HD12"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5090979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="110" mass="12941" checksum="FAFADAF41AAA36AB" modified="2022-05-25" version="1">MHKSLKLSIKYCGQYRFKYYDKNNIDKPCNENNYNIYNNNNLKIAKFFPPKSSDSSKTFAELCKPSSAMRRRAKIYGFLLKYICIPTVIIGGIITKINYDIEKRCREAHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HD34</accession>
    <name>A0A8J2HD34_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Similar to ZNF569: Zinc finger protein 569 (Homo sapiens)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">HICCMSTLAB_LOCUS7011</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5093685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HD34"/>
    <dbReference type="OrthoDB" id="427030at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032502">
        <property type="term" value="P:developmental process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040029">
        <property type="term" value="P:epigenetic regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001370">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000006">
        <property type="entry name" value="Zinc finger protein 184 (Kruppel-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000690">
        <property type="entry name" value="Zinc finger protein 354C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000202">
        <property type="entry name" value="Zinc finger protein 574"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000852">
        <property type="entry name" value="zinc finger protein 629 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000624">
        <property type="entry name" value="zinc finger protein 697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000176">
        <property type="entry name" value="zinc finger protein 70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050826">
        <property type="entry name" value="Krueppel_C2H2_ZnFinger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012934">
        <property type="entry name" value="Znf_AD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24377">
        <property type="entry name" value="IP01015P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13912">
        <property type="entry name" value="zf-C2H2_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51915">
        <property type="entry name" value="ZAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="12"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="4 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="11" id="KW-0804">Transcription</keyword>
    <keyword evidence="9" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="8" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="7 14" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 13" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="ZAD" evidence="16">
        <location>
            <begin position="81"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="313"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="343"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="372"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="400"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="429"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="457"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="485"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="513"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="542"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="571"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="599"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="627"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="83"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="139"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CAG5093685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="814" mass="93880" checksum="B4DD3E45D35CDA35" modified="2022-05-25" version="1">MSSQSQVTVTPALPSLLGIKSLRFRNGVNGVGTSFSSQSLTTSSSLSTSTPYPPLLLAANRSEKQKEIFKCKMTESVKEMLYCLICNIKFSTSTRNSIKIFDKNSLCDSQKTILSALNLVLETEVTEDNVHSDVICKKCYKLFNEYDELTNRLAEIKHDIFENYRKTVKKLTDIVEEEYNDHDYVDQENHVLEEFSPHAIDEDSNKTKDLLPAKEEHVDIEYLQEDDSENIINEEYIDNPSPAKIILVKTEQTKNKEVSRRVRSSRDENEPLLHRDKNTNTYTCLLCPDDDQIAGDTREIVAHLKASHDIRLYVCDMCGAEFKKRNELSSHMDEHIAKEDGDFQCEYCNRIFSNLRLFRIHKRVHYPQAKSWTCDQCGKKYSSKNLLEEHRNTHTGNRPYVCQICKKDFASKYTFKAHEKTHEVRPRPFECKECNKTFLSQQNLTQHERTHLGIKEFVCQHCGKAFGSQHNLEVHNIVHTGHKPYVCDQCGKAFARKAEIRDHERTHTGEKPYQCEFCGATFSQRSNLQSHKRATHYNDKRYKCDDCGKGFKRRRLLDYHIKAQHTGERPFKCETCSATFVYPEHFKKHMRIHTGEKPYLCEVCGKAFNSRDNRNSHRFIHSDKKPYECLVCGMGFMRKPLLYTHMQNLGHLNDTIVVNQPRLTTTEERVITIPEGTQLLIDGEQEEDMEDTELYVTDLKDHVIIQEDENIYQHEDGLDIASDENIAADQIEHIVVNNQIAFADGSMIECKAEDAEEDAEMYSYTDDGETMVVPASEYKNLIGNSKGPVRLVQMRILNPGSDGKSYVSLVQQDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HDM8</accession>
    <name>A0A8J2HDM8_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CRK SH3-binding GNRP</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HICCMSTLAB_LOCUS7605</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5095229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HDM8"/>
    <dbReference type="OrthoDB" id="25179at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007265">
        <property type="term" value="P:Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00155">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06224">
        <property type="entry name" value="REM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.840.10:FF:000009">
        <property type="entry name" value="rap guanine nucleotide exchange factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.840.10">
        <property type="entry name" value="Ras guanine-nucleotide exchange factors catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.870.10">
        <property type="entry name" value="Son of sevenless (SoS) protein Chain: S domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008937">
        <property type="entry name" value="Ras-like_GEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000651">
        <property type="entry name" value="Ras-like_Gua-exchang_fac_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023578">
        <property type="entry name" value="Ras_GEF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001895">
        <property type="entry name" value="RASGEF_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036964">
        <property type="entry name" value="RASGEF_cat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113">
        <property type="entry name" value="GUANINE NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113:SF224">
        <property type="entry name" value="RAP GUANINE NUCLEOTIDE EXCHANGE FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00617">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00618">
        <property type="entry name" value="RasGEF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00147">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00229">
        <property type="entry name" value="RasGEFN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48366">
        <property type="entry name" value="Ras GEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50009">
        <property type="entry name" value="RASGEF_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50212">
        <property type="entry name" value="RASGEF_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-terminal Ras-GEF" evidence="6">
        <location>
            <begin position="681"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-GEF" evidence="5">
        <location>
            <begin position="829"/>
            <end position="1042"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="25"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="184"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="226"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="300"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="407"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="520"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="190"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="226"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="256"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="309"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="421"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="457"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="552"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00083313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAG5095229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="1051" mass="117152" checksum="35DAF63B97EC0A4C" modified="2022-05-25" version="1" fragment="single">VEERPSGKARGSKLARRARSFKEDFLEKFSQMRSPGINSGGVGGGGGGGGTGPGNTGGVTTRAASPSSPRTPREKNTPIANDTLEKNPLRDLHIHVRQVQLALLHFRDVVSKKKLEISTLGSATNQVYQALAQLLKLCDDVLLHGDQSAPCPALDTENVTHVIGLVEDAVKNLVSLAHEKITNRQKPAPITTNNRTSGYGTEINSQRNSLPDIPLTPRERQILEQTAASSTLVRSSHSSESILRDSSPPPKPPLPDRTNISLSEENSSSTPPPLPPKRRTRAQQLLDESDGFLASSLDRCSLRSRSPEDSSSLLSASAGSLDSALNHSRDEDEIRAIMGPNDESLNDSMDLSLMATIHGLQLNGTNNCTGWDGSETSIPTTMLLGQQTPQEILGPFTTGIEGKMERLSTQTQESGFVSMHSQRSSSQSYTTSSSLTSKRSSQQSSVSYNSQSYNSSMAQHQLHQQMSFSQQKISADTENSIVTHRTTSHSSTKNTVTTTTISGDADSALLEKLEIEELESNGIPPALPEKRSKKRKERLPSQYDNVPENEHLSTCSLHTSSSDSPDASKPPPLPLKKRHIMAYMEMFGNCSHSTNDFISGLGTRHSVAAYNSMQAEWQQHEMSLTTTQSYSRSSSRPASNALSSISVDENTLELRDIDQDDGILDELDISKYLVLKKPEEDGPDIRGGHPDALLIHATKANKHDFLYQEAFLTTYRTFMSPLELIQKLHKRHQRFSCSGDIIKQRAAREAFSLLVRVVSDLTMSDLDDVLLQTLMEFVQQLVCSGDLTMAKALRVKILEKHALKQLQSAQPILSSLSVSTKQASLLDFKSEQIAEQMTLLDAELFMKIEIPEVLIWAQEQNEERSPNLTRFTEHFNKMSYWARSRILEHRMENEAKDREKYVVKFIKIMKHLRKINNFNSYLALLSALDSAPIRRLEWQKHITEGLKEYCALIDSSSSFRAYRQALAETQPPCIPYIDLLPDGTINFSKRWQQFNIVENMKRFKKGTYSFKKNERIITFFNNFSDFLCEEAMWQISESIKPRGGKKPQSQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HEQ5</accession>
    <name>A0A8J2HEQ5_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Similar to FBXO32: F-box only protein 32 (Homo sapiens)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HICCMSTLAB_LOCUS8009</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5096037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HEQ5"/>
    <dbReference type="OrthoDB" id="9991467at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040394">
        <property type="entry name" value="FBX25/32"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13123">
        <property type="entry name" value="LD30288P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13123:SF7">
        <property type="entry name" value="LD30288P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0833">Ubl conjugation pathway</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAG5096037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="347" mass="40005" checksum="2B57AFBA201361A7" modified="2022-05-25" version="1">MPFISKDWRSPGEEWVKTVEGWEKKKILECANNKTLSLLIRTEKDGDKAREKEKEKEKKKENAVQPHCHITLKCTREIAGFNGLSDALKRLDFLSAVHDCRRFNYIVRLLDLLVSHTMGGLSGCAQRVLFNMLEEVTLEVSCSQQQTGRLRRLIERVRAFSASCCWGGRPLGSVVLWEKHKAALDRILQIASSITITQPDEEQHPQWSDLPAECRREVLLRLSDPRDIEASSEACEHLAALAQEQRIWRELAQYHFTPQQITTTMQNNPGKDWKTLFTIARRSFGLREEYAEMIQLCRNCRCLFWRSLGHPCIADQDPAFQEKLADVDQSSLHVPIPPQTFLKFFSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HF47</accession>
    <name>A0A8J2HF47_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">N(6)-adenosine-methyltransferase non-catalytic subunit METTL14</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Methyltransferase-like protein 14</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HICCMSTLAB_LOCUS8573</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the MT-A70-like family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5097163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HF47"/>
    <dbReference type="OrthoDB" id="14833at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036396">
        <property type="term" value="C:RNA N6-methyladenosine methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045123">
        <property type="entry name" value="METTL14-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007757">
        <property type="entry name" value="MT-A70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13107">
        <property type="entry name" value="N6-ADENOSINE-METHYLTRANSFERASE NON-CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13107:SF0">
        <property type="entry name" value="N6-ADENOSINE-METHYLTRANSFERASE NON-CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05063">
        <property type="entry name" value="MT-A70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51143">
        <property type="entry name" value="MT_A70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51592">
        <property type="entry name" value="SAM_MTA70L_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="331"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="344"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00032942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00049757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAG5097163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="360" mass="41064" checksum="A954BC45DFD7DDC9" modified="2022-05-25" version="1">MLQVLRERSQKRKKLLAQALGVANPDELREALGTDVDGIQKKKARVRIIKSDQEKTKDQKDNIVLGDEIVYKDSSTFLKGTQSSNPHNDYCQHFIDTGQRPQNFIRDVGLADRFEEYPKLRELIKLKDDLISETATPPMYLKTNLSTYNLKELNCKFDVILIEPPLEEYQRTCGATNVELWNWDQIMELDIGEVAANRSFVFLWCGSSDGLDMGRFCLRKWGFRRCEDICWIRTNIDNPGHSKNLDSKAVLQRTKEHCLMGIKGTVRRSTDGDFIHANVDIDLIISEEPEYGSIEKPVEIFHIIEHFCLGRRRGYFASGQTTTGCTERIEALRPKSPPPKGKVAGRGRGAFNRGGRGRGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HFH8</accession>
    <name>A0A8J2HFH8_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Similar to ZNF382: Zinc finger protein 382 (Homo sapiens)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HICCMSTLAB_LOCUS8881</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5097795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HFH8"/>
    <dbReference type="OrthoDB" id="10004641at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000446">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="5">
        <location>
            <begin position="50"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAG5097795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="124" mass="13979" checksum="228AFADFB97D18AB" modified="2022-05-25" version="1">MLVLSYGDGYLPASQSSSDNEEIYPQNLLGVAYKTSVNNSKEVRDDDGKYVCTKCGKSYIASTSLKRHQRLECGVDPAQKCHICNRRFRHKFVLTAHINNCERKLLGIEVIEIIKKNPNNSKSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HFX0</accession>
    <name>A0A8J2HFX0_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Similar to Elp3: Elongator complex protein 3 (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HICCMSTLAB_LOCUS8691</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5097405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HFX0"/>
    <dbReference type="OrthoDB" id="10265243at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033588">
        <property type="term" value="C:elongator holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002926">
        <property type="term" value="P:tRNA wobble base 5-methoxycarbonylmethyl-2-thiouridinylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039661">
        <property type="entry name" value="ELP3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056591">
        <property type="entry name" value="ELP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058240">
        <property type="entry name" value="rSAM_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11135:SF0">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11135">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23613">
        <property type="entry name" value="ELP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102114">
        <property type="entry name" value="Radical SAM enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="ELP3-like N-terminal" evidence="6">
        <location>
            <begin position="16"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF23613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAG5097405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="197" mass="22150" checksum="CBD4CE777ADD849F" modified="2022-05-25" version="1" fragment="single">MARKKKVFIESKEERMMLTIQEVIQELLVAHDEHRDVDLNKLKTRVSSKYGLESSPRLVDIIAAVPLDAKNKLIPKLKAKPIRTASGIAVVAVMCKPHRCPHINFTGNICVYCPGGPDSDFEYSTQSYTGYEPTCTRLEIGVQSVFEDVARDTNRGHTVKAVCETFNIAKDTGYKVIAHMMPDLPNVDIERDVEQFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HG32</accession>
    <name>A0A8J2HG32_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9 10">General transcription factor IIH subunit 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HICCMSTLAB_LOCUS7207</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Component of the general transcription and DNA repair factor IIH (TFIIH) core complex which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the 7-subunit TFIIH core complex composed of XPB/ERCC3, XPD/ERCC2, GTF2H1, GTF2H2, GTF2H3, GTF2H4 and GTF2H5, which is active in NER. The core complex associates with the 3-subunit CDK-activating kinase (CAK) module composed of CCNH/cyclin H, CDK7 and MNAT1 to form the 10-subunit holoenzyme (holo-TFIIH) active in transcription. Part of TBP-based Pol II pre-initiation complex (PIC), in which Pol II core assembles with general transcription factors and other specific initiation factors including GTF2E1, GTF2E2, GTF2F1, GTF2F2, TCEA1, ERCC2, ERCC3, GTF2H2, GTF2H3, GTF2H4, GTF2H5, GTF2A1, GTF2A2, GTF2B and TBP; this large multi-subunit PIC complex mediates DNA unwinding and targets Pol II core to the transcription start site where the first phosphodiester bond forms.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the TFB2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5093881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HG32"/>
    <dbReference type="OrthoDB" id="364513at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000439">
        <property type="term" value="C:transcription factor TFIIH core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005675">
        <property type="term" value="C:transcription factor TFIIH holo complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001671">
        <property type="term" value="F:ATPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.2610:FF:000001">
        <property type="entry name" value="General transcription factor IIH subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2610">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040662">
        <property type="entry name" value="Tfb2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004598">
        <property type="entry name" value="TFIIH_p52/Tfb2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00625">
        <property type="entry name" value="tfb2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13152:SF0">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIH SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13152">
        <property type="entry name" value="TFIIH, POLYPEPTIDE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03849">
        <property type="entry name" value="Tfb2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18307">
        <property type="entry name" value="Tfb2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6 10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 10" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Transcription factor Tfb2 C-terminal" evidence="11">
        <location>
            <begin position="392"/>
            <end position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00064576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00070130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU364024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF18307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAG5093881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="466" mass="53218" checksum="EE6DB8FE405AD12A" modified="2022-05-25" version="1">MSAPPTGQNLLRSSALECKDLHEYLKSRPPEILNRLYHNPPICLAVFRELPTIARHYVMRLMFVEQPVPQAVIASWCSKLHSDDHRNVVQVLNELNVWKEASIPGGMPGWTLNSTFKKNLKIVLIGGGKPWTMSTQMETDNKPRDEAFLDSYAIQRWECLLHYMVGSSDQQGISADAVRILLHAGLMNQESDGSPVITKAGFQFLLLDTASQVWYFILQYLDTIEARGLDLVECLTFLFQLNFSILGKYYSTEGMSANLLTFLQHLREFGLVFQRNRKSGRFYPTRLALNIATGKNKPMARDIEKEGYIVVETNYRVYAYTSSQLQVALLGLFCEMLYRFPNLVVAILTRDSVRQALKSGITALQIIGFLRQHAHGKMIEAGPPTLPPTVVDQIKLWENERNRFTFSEGVLYSQFLSQTDFETLRDHASSTGVLIWHNDRKRTMVVAKAGHDDVKRYWKRFSKTSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HGS0</accession>
    <name>A0A8J2HGS0_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Mitochondrial (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HICCMSTLAB_LOCUS7617</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TTC19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5095254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HGS0"/>
    <dbReference type="OrthoDB" id="5986190at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034551">
        <property type="term" value="P:mitochondrial respiratory chain complex III assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040395">
        <property type="entry name" value="TTC19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13143">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13143:SF6">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 19, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAG5095254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="343" mass="39425" checksum="680676101959CC1B" modified="2022-05-25" version="1">MSRFWSATNFIKRISFNTIKRPVTGFKSIVKNIPSNNEEKRNWSYFMMGFTIFGFNFSKGEEEVEPELIMTIKRSILLIQKGEYKKAEQMLHVALRQAQTLGHFEGITYVYDVMANLAFQVGEIQKAKDLFKTVMQRLLSTGTDQNDTKIIHISLKVAKLFEQSGDIKTAEEGYKFCIENIEEHAIKNPTDEDILVLWAMSRDWYARMLLSESRLSEALENYQKAYQLCVKVYGNSHEQTVVLLNDLGTVYCLLGQHDRALGYLNDAIERGIKLEDCQELSSVYVNLGNVYIKKSLYNQAKMACFEGLKRAKKNEDEACQEQANSCLDEVKKYLNTVTKIDNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HHI6</accession>
    <name>A0A8J2HHI6_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Seipin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HICCMSTLAB_LOCUS10429</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5101356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HHI6"/>
    <dbReference type="OrthoDB" id="3990054at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140042">
        <property type="term" value="P:lipid droplet formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd23995">
        <property type="entry name" value="Seipin_BSCL2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009617">
        <property type="entry name" value="Seipin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21212">
        <property type="entry name" value="BERNARDINELLI-SEIP CONGENITAL LIPODYSTROPHY 2 HOMOLOG BSCL2 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21212:SF0">
        <property type="entry name" value="SEIPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06775">
        <property type="entry name" value="Seipin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="34"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="152"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="227"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="271"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="271"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAG5101356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="329" mass="38412" checksum="430F3D882E9E3E82" modified="2022-05-25" version="1">MFFSKTIKVTFEKLFNAKQQTVKGVQSVFFRSGFIFIGSVVAVWISIFLYTAFYYAYMPNMQHIRPVHFEFDSCQTLKGPSSWPSAFVRFTKKQQFLMVGQPYKINLYLEMPESTTNKELGMFMVCSSLKTHNHGIIDKSCRPTMIHYRSTLLHYLTTLAFSPMLIFGAREEKQNIMLELYRNFEEDQNHPVTSISIEIKSKFIEFYSATIEIHAHLYGLRYLMFHWPILTAIIGITTNLFFISLIFILSYLHFTYEEDLQDEQFSYEKGQMEKSTHKNSTDLSSESSSIEDASLLDDLIKSSDESNKLDLNLPEDKSRYIEEIKSKPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HHN9</accession>
    <name>A0A8J2HHN9_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Similar to ANKLE1: Ankyrin repeat and LEM domain-containing protein 1 (Homo sapiens)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HICCMSTLAB_LOCUS7935</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5095892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HHN9"/>
    <dbReference type="OrthoDB" id="1601181at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004520">
        <property type="term" value="F:DNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000712">
        <property type="term" value="P:resolution of meiotic recombination intermediates"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10454">
        <property type="entry name" value="GIY-YIG_COG3680_Meta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12934">
        <property type="entry name" value="LEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.720.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034998">
        <property type="entry name" value="ANKLE1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011015">
        <property type="entry name" value="LEM/LEM-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003887">
        <property type="entry name" value="LEM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46427">
        <property type="entry name" value="ANKYRIN REPEAT AND LEM DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46427:SF1">
        <property type="entry name" value="ANKYRIN REPEAT AND LEM DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03020">
        <property type="entry name" value="LEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22945">
        <property type="entry name" value="LEM-3_GIY-YIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00540">
        <property type="entry name" value="LEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63451">
        <property type="entry name" value="LEM domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50954">
        <property type="entry name" value="LEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="74"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="domain" description="LEM" evidence="3">
        <location>
            <begin position="737"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="371"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="482"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="634"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="371"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="486"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="512"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="634"/>
            <end position="646"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG5095892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="1005" mass="115126" checksum="CC393E7EBA6F04A1" modified="2022-05-25" version="1">MYLASSLYDGLEDNNMNQVKALLKEKDADPNILIPSYGISPFHLVIGNESEAFAEEVTKLFLRHGGDPNVRSIDRMTPVHVAAAWGRVRVLELLLANGGDPLCVDDENHTPFHYALEGSFYEAVSVLAKFSCKTQDDDEDSNSDSDKPKVQITLEKIFINNGNVVAEYVPSDIDFTNHTVDEKKQNTKNFNDLSSYKSDGSSSYNLPDDFSVQKAYSYTTNDDSFDNLPNDNITFRRRPRANRNDCVNKNAISPILPDDIVSELKSGFIRDEQKLVKNIIKRLSNSFEKTTGSWANKKLNDEMKNKHTKKFVSLLPQPKIFKNNLQFMNKKQSKTLLDTSIISKSPNFHININRNYNNKFNTSNSLESESLMNQMSLSQSSTSSSAKSASSTPRKETEIVQCKSKEKKCLNNNINRNSLNLSYNERDYVSSFSTNNEYKSDIDDSYFLKNIIRNLNDSFEDDYDKENSELINSEILMNNRGLKLNGDSKKNLEEKTKPRSFKGSHLLLPSKNLKENTRDRNVDKHSNKEEIKQDKELNISFHDKIKSILESPGSSTPTSNYLSVRSELSDQEELDLHYEINNIFKGNKTPPASISKRSDESWATDESTALSDDFTNSLLIYKPSIDTSYEYESSVQSQKDSSNNQLKVEDKMQSSDTDTYETPLRSFSSSTSNDSFVTVEEQYHYVDPERKKAFLERRLCVIPKLDEPVDHISESSYLEEMSENNESGPLRVVHKPVQGKQILANCDLRNRLITLGEQPGPITSTTYHVYLKRLTKLEKNVDLNARMQELSLKDEIKLSPVVKNGLFDPWACNLQPFQDLEDRVFKEFETPKPNRRYRGGISKSYFNYILLDPRITNNLPRNGRYLSPGQRWNIFLKAIFYIGKGKASRPAAHLYDAFDFWFKNKSDEPSNKIQKILDIWRESKGVICLHVYMNRMQEEAFTREAAMIDAIGLDKLTNCVRGNYYGIITTMNNLDKIGMGNYLLYKAMEIFMYEGERQLFPQSIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HIN3</accession>
    <name>A0A8J2HIN3_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similar to mxt: Eukaryotic translation initiation factor 4E-binding protein Mextli (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS10983</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5102374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HIN3"/>
    <dbReference type="OrthoDB" id="6357832at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034518">
        <property type="term" value="C:RNA cap binding complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008190">
        <property type="term" value="F:eukaryotic initiation factor 4E binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045727">
        <property type="term" value="P:positive regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901190">
        <property type="term" value="P:regulation of formation of translation initiation ternary complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040160">
        <property type="entry name" value="Mxt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20849">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4E-BINDING PROTEIN MEXTLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20849:SF2">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4E-BINDING PROTEIN MEXTLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="2" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="238"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="385"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="259"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="273"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5102374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="471" mass="52414" checksum="7246823C4F9849C2" modified="2022-05-25" version="1">MASTQLTPRPRMTKKHEKPRPLKLNLRHSSIDERIATVEDLVSLIDNVASNLSNGFHDPTLQQNIITMCNTLKQCAHQFEPVYKDQLDRAFVAIRNGSQDERLDLTTRIHLLELIELRAKQWRYNDSMDAYYASKLADLNEPDNMIGVDGINNQVATLNLTSPQTPPVLGVGEVIKTSGKFTKPTRIPGKNYCKDEVVIRNSDSGKGKTCSHDRGAQRDDHLLSASYAKDLIKETIQRNASPVRMGPARAADSSGIGGSSSSLNSSASDESNRLSQQFQQPSQIRSTLLHSLSTNDASIGDYKHTVNVGNHSLKITGSNLNLVRTAKIILDEHFSKWSGDSGIESFDFTDDFPSFPNTPINNQQIKIPDNNANVDVDAAVKRENSLESNATSESEETFKSNNQTIKEKINNRRNGPYAKRPPANWARIKEECPNIIRKSPIRWFEPDTYKAKVAAAGMRTVLSSAEEIDLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HIW5</accession>
    <name>A0A8J2HIW5_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase B (Danio rerio)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HICCMSTLAB_LOCUS11165</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5102750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HIW5"/>
    <dbReference type="OrthoDB" id="2016523at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005793">
        <property type="term" value="C:endoplasmic reticulum-Golgi intermediate compartment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005795">
        <property type="term" value="C:Golgi stack"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008375">
        <property type="term" value="F:acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006759">
        <property type="entry name" value="Glyco_transf_54"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057279">
        <property type="entry name" value="MGAT4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056576">
        <property type="entry name" value="MGAT4_A/B/C_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12062:SF9">
        <property type="entry name" value="ALPHA-1,3-MANNOSYL-GLYCOPROTEIN 4-BETA-N-ACETYLGLUCOSAMINYLTRANSFERASE A, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12062">
        <property type="entry name" value="N-ACETYLGLUCOSAMINYLTRANSFERASE VI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04666">
        <property type="entry name" value="MGAT4_cons"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23524">
        <property type="entry name" value="MGAT4A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="15"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="domain" description="MGAT4 conserved region" evidence="6">
        <location>
            <begin position="104"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="domain" description="MGAT4 A/B/C C-terminal" evidence="7">
        <location>
            <begin position="396"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="40"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF23524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG5102750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="442" mass="51134" checksum="481626EA6565E637" modified="2022-05-25" version="1">MTARVNNGVSFRKRFIVVLMIILTSYIILNIISFPDITKEIVLQNEIAELQVKLETLQNKHVSTQEEINSLTHHLLSLSKNAQTLPNFRFLFNNETLNTTAVKLPSVHNFLPHFLNDPNSLKPAFLQSKGRSGINMILGIPTVKRDVQNYLLATLKNLVECMDSNEASDTLIIVLIAETDIDYVSYVAQQIGSQFPEELNSGLIEIISPSPSYYPDFSEVKDTLGDTHQRVVWRSKQNLDFAFLMSYAYTKGTFYIQLEDDILAKKNFISIMKSYALKKINLKENWFILDFCQLGFIGKLFKCVDLPWLIQFFLMFYSDKPVDWLLDHLISTKICSLDRDSKNCKIAKAELWLHYKPSLFQHIGIHSSLKGKMQKLKDKQFGKITLFYTHNNPRAIVESEIKVYKQYTLDKAYRGESFFWGLLPQIGDHIKFKFSRPIFIKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HJB9</accession>
    <name>A0A8J2HJB9_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Similar to Kcnj12: ATP-sensitive inward rectifier potassium channel 12 (Mus musculus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">HICCMSTLAB_LOCUS6689</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>K(+)(in) = K(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29463"/>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Membrane</location>
            <topology evidence="1 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5093248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HJB9"/>
    <dbReference type="OrthoDB" id="273257at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034702">
        <property type="term" value="C:monoatomic ion channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005242">
        <property type="term" value="F:inward rectifier potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990573">
        <property type="term" value="P:potassium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034765">
        <property type="term" value="P:regulation of monoatomic ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1400:FF:000001">
        <property type="entry name" value="G protein-activated inward rectifier potassium channel 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000078">
        <property type="entry name" value="Putative Inward rectifier potassium channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1400">
        <property type="entry name" value="G protein-activated inward rectifier potassium channel 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041647">
        <property type="entry name" value="IRK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016449">
        <property type="entry name" value="K_chnl_inward-rec_Kir"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013518">
        <property type="entry name" value="K_chnl_inward-rec_Kir_cyto"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040445">
        <property type="entry name" value="Kir_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11767">
        <property type="entry name" value="INWARD RECTIFIER POTASSIUM CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11767:SF102">
        <property type="entry name" value="INWARDLY RECTIFYING POTASSIUM CHANNEL 1, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01007">
        <property type="entry name" value="IRK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17655">
        <property type="entry name" value="IRK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005465">
        <property type="entry name" value="GIRK_kir"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01320">
        <property type="entry name" value="KIRCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 12 16" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8 12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 12" id="KW-0630">Potassium</keyword>
    <keyword evidence="3 12" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 12" id="KW-0813">Transport</keyword>
    <keyword evidence="5 12" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="99"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel inwardly rectifying transmembrane" evidence="14">
        <location>
            <begin position="5"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="Inward rectifier potassium channel C-terminal" evidence="15">
        <location>
            <begin position="135"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="16">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00034430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF01007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF17655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CAG5093248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="316" mass="36576" checksum="92304F1079D9F095" modified="2022-05-25" version="1" fragment="single">IRFLLQDIFTTLVDAQWRWTLLVFSMNFLLSWLGFAIVWWLIVYSHGDFNNDDFSTANKTLTPCVEDIHSFTSCFLFSVETQHTIGYGSKHTTEECPEAIFVMCIQSMTGVILQAFMVGIVFAKLSRPKKRTQTLLFSRNAVICQRDGLPCLMFRVGDMRKSHIIEAHIRAQMIKKKVTREGESLPFFQTELKVGGDGEEDKIFFIWPTTIIHKIDQFSPLYYLSASDMLRERFEIIVMLEGVIESTGMTTQARSSYLPSEILWGHRFEHMISFRKETGEYEVDYMLFNNTYEVDTPLCSAAQLIEVRENNDNNQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HK20</accession>
    <name>A0A8J2HK20_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Similar to Picot: Putative inorganic phosphate cotransporter (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HICCMSTLAB_LOCUS7080</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5093754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HK20"/>
    <dbReference type="OrthoDB" id="2985014at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006820">
        <property type="term" value="P:monoatomic anion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17318">
        <property type="entry name" value="MFS_SLC17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000512">
        <property type="entry name" value="Putative inorganic phosphate cotransporter-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000003">
        <property type="entry name" value="Solute carrier family 17 member 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050382">
        <property type="entry name" value="MFS_Na/Anion_cotransporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11662:SF415">
        <property type="entry name" value="AT30085P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11662">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0769">Symport</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="41"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="112"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="139"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="165"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="201"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="233"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="341"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="372"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="396"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="427"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="462"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="39"/>
            <end position="489"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAG5093754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="518" mass="57320" checksum="DB00CF7CAF6DF512" modified="2022-05-25" version="1">MPRKQKFTETIPLLPKRKAGILSNLPTMEIPQRGIQIQQRWVFAIMGFLAIFNAYTMRVCLSITITEMVVSEHKNTSTVIDDDVCSNENHQQDPPVNSTSGSYHWDESLQGIILSSFYWGYVITHIPGGMLAEKFGGKYSLGLGILSTAIFTLLTPLAVDIGGATALIILRVLMGLGEGTTFPALNAMLAQWTPPEERSKIGSLVFAGALLGTVFTTSISGLIMHYSTVGWPAVFYVFGSIGVLWFFVWVLVCYNNPSEHPFISENERKFLHERMSAHTHKKPPAVPWRHVLTSAPVWALITAQIGHDWGFFTMVTDLPKYMSSVLKFSIKSNGYLSSLPYLSMWICSILSSWFADWIITAGHLSRTNVRKIGTTIASVGPGVFIVAASYAGCDGYTVVAMFTIGMTLMGTFYPGMKVNALDLSPNYSGTLMAVVNGVGAFTGIITPIVVGELTPNNTNAQWRLVFWIVFIVLVITNMVFILYASGEVQHWNNPEFIRADRAKRRKKQEGEIDSRSPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HKQ6</accession>
    <name>A0A8J2HKQ6_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Similar to GRB14: Growth factor receptor-bound protein 14 (Homo sapiens)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HICCMSTLAB_LOCUS11897</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5104228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HKQ6"/>
    <dbReference type="OrthoDB" id="8815311at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.10">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015042">
        <property type="entry name" value="BPS-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039664">
        <property type="entry name" value="GRB/APBB1IP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000980">
        <property type="entry name" value="SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11243">
        <property type="entry name" value="GROWTH FACTOR RECEPTOR-BOUND PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11243:SF38">
        <property type="entry name" value="GROWTH FACTOR RECEPTOR-BOUND PROTEIN 14-LIKE ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08947">
        <property type="entry name" value="BPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00017">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00401">
        <property type="entry name" value="SH2DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00252">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55550">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50001">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0675">Receptor</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0727">SH2 domain</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035173675" evidence="3">
        <location>
            <begin position="19"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="SH2" evidence="4">
        <location>
            <begin position="75"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="167"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="167"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAG5104228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="206" mass="23369" checksum="C3EA0586F28D11C8" modified="2022-05-25" version="1">MLLLLLLFYWQEPPILVAMDFSGKYGKIVEDPKEAKAITEGKGMLPQPQLRPPASRLQVHNYPRVDPSRYFNEDWYHMTIGRESAARLVKLARKNGTFLVRESTSNNGYQFVLTYVHEDKPVHTPIVNNGTTKFLDLVQLVNFYQLNQGSLPTRLTYFVSKNATKLSPTKNNSVSTGTTSPLSKNRNSPQKISEDQSAILSRLPRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HKS7</accession>
    <name>A0A8J2HKS7_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to selenbp1-a: Methanethiol oxidase (Xenopus laevis)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS10386</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the selenium-binding protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5101313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HKS7"/>
    <dbReference type="OrthoDB" id="10252446at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008430">
        <property type="term" value="F:selenium binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008826">
        <property type="entry name" value="Se-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23300">
        <property type="entry name" value="METHANETHIOL OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23300:SF0">
        <property type="entry name" value="METHANETHIOL OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05694">
        <property type="entry name" value="SBP56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75011">
        <property type="entry name" value="3-carboxy-cis,cis-mucoante lactonizing enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0711">Selenium</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5101313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="307" mass="34092" checksum="3543F60DB5F3B495" modified="2022-05-25" version="1">MATAKDCKKCGPGYRSPKEAMAGPREKIMYVVCISTDDNKPDVLSTVDVDPTSPTYCQIIHKLRMPYVGDELHHAGWNICSSCPDSKLKRDTFVLPCLMSDRVYFIDTSNARAPAIKKVLEPEEMHKHGLATPHTAHCSPTGEIIISTMGKPNGDGLGDFLCVDSETLQVKGPWTLSDRKAKFGYDFWYQPSHDVLISTEWGVPRIFKKGFGPGQSSNPDIYGRNLNFYSWTKHSLEQVIDLGEEGIAPLEVRFLHDPLASEGFVGCAVSSNIFRFYKTDDGKWAADKVIDVPEKKVQGWMGPTISG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HL16</accession>
    <name>A0A8J2HL16_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similar to SK: Small conductance calcium-activated potassium channel protein (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS10728</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5101864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HL16"/>
    <dbReference type="OrthoDB" id="73653at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034220">
        <property type="term" value="P:monoatomic ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0407">Ion channel</keyword>
    <keyword evidence="2" id="KW-0406">Ion transport</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5101864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="246" mass="26222" checksum="61F8203A01B53C29" modified="2022-05-25" version="1">MNSTGNAGSQEGGNSGEYGSSEETAALLTRGPPPPVVVSSGSHQGKPVLTRQDRATFLVASPQLSVSGLGGSEESGTNEDPATRSVPDIELHCRLDGEPQHLQQQQQCHHPTTTTIYRARQPSHQYSRCRCDRRDSLAPSSALHLARSVSRESVRSGHHCCPCQAPPPPVLVTTSPSTRIIRQSSQPEASACCCSGCYCPLHSNTAPSASLRQLREPGDGIAGIAADSLRINGGIRQFRQVNYLSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HLF2</accession>
    <name>A0A8J2HLF2_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Odorant receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HICCMSTLAB_LOCUS9996</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Cell membrane</location>
            <topology evidence="1 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the insect chemoreceptor superfamily. Heteromeric odorant receptor channel (TC 1.A.69) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5100923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HLF2"/>
    <dbReference type="OrthoDB" id="7634903at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005549">
        <property type="term" value="F:odorant binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004984">
        <property type="term" value="F:olfactory receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004117">
        <property type="entry name" value="7tm6_olfct_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21137">
        <property type="entry name" value="ODORANT RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21137:SF35">
        <property type="entry name" value="ODORANT RECEPTOR 19A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02949">
        <property type="entry name" value="7tm_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 10" id="KW-0552">Olfaction</keyword>
    <keyword evidence="8 10 11" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="9 10" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="51"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="85"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="142"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="210"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="281"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="318"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU351113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAG5100923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="411" mass="47360" checksum="2017FB3ADEEABEAD" modified="2022-05-25" version="1">MALNQGETILSNKSENCHKHKAVKYTYFFLNLLGIGPLTTESLTITKIVSFIWSVTIVAIGVWEMSFRFIYIYFDVTDVDDQMDLLAPVVLLAVIILKYTSIIYRHDTIKKFTKHIIDDWSMIGNQEEEDIMKKNLNMSNNITFVFAVMMYLCCVLYNCLMPHVIPLLFNSSDQNSSERIVIFPGYNSVFDVDSFPIYQITYVFHQLTALSGYTILITSCNLIVVLVTHACSQLQIITNQIDSLLNNFSKKEKFSYTKLSFTISRHVRVLEFSNKLLKKMIFELCLIEVGASSILLCIDEFCVLRLLEKKEFANMTSYIMIFFSLSFNILIICYFSELLEAQFMNVGEKLNSVEWYKTPVNTRQYFNLIIIMSQQPQKISAGGIVDLSFVTYLQILKSGFAYLQLLRASNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HML3</accession>
    <name>A0A8J2HML3_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Similar to Hlx: H2.0-like homeobox protein (Mus musculus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HICCMSTLAB_LOCUS9002</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the H2.0 homeobox family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5098038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HML3"/>
    <dbReference type="OrthoDB" id="6159439at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052497">
        <property type="entry name" value="H2.0_Homeobox_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020479">
        <property type="entry name" value="HD_metazoa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000047">
        <property type="entry name" value="HTH_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46808">
        <property type="entry name" value="H2.0-LIKE HOMEOBOX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46808:SF1">
        <property type="entry name" value="H2.0-LIKE HOMEOBOX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00024">
        <property type="entry name" value="HOMEOBOX"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00031">
        <property type="entry name" value="HTHREPRESSR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 6 7" id="KW-0371">Homeobox</keyword>
    <keyword evidence="4 6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="9">
        <location>
            <begin position="113"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="6">
        <location>
            <begin position="115"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="91"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="173"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="97"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="184"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="194"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="211"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAG5098038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="221" mass="25234" checksum="B0A4F89AD8E8A7A9" modified="2022-05-25" version="1">MEYSVESSKLKFGVERILSSDFCNKTLPIPKVTIKLFGNYSGQECHCIGGCNKCMNFCNFTSESLCAPNYTSVIEKYQSICRPAPLRPIPRVPVSSTTTTTTTTNNTESGSRRKRSWSRAVFSALQRKGLEKRFSLQKYITKPDRRQLAATLGLTDAQVKVWFQNRRMKWRHNKESENIIPEGSDSQKNLPKHQNQNQNSQKSSNSKLELSDEEEEIQVDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HNP3</accession>
    <name>A0A8J2HNP3_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS12897</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5107745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HNP3"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5107745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="85" mass="9621" checksum="644E630B39864AC4" modified="2022-05-25" version="1" fragment="single">NYKEVNIIDINNYMICLGRRAARGDDGVGDKCIASLIDVKFDFFITENRLHHTAIAKNIPQMAIFSCQKSNVTLQTIEFKLATDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HNQ3</accession>
    <name>A0A8J2HNQ3_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SAM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS11204</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5102828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HNQ3"/>
    <dbReference type="OrthoDB" id="8192917at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31025">
        <property type="entry name" value="SI:CH211-196P9.1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31025:SF9">
        <property type="entry name" value="SI:DKEY-286J15.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="838"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="999"/>
            <end position="1032"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="838"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="999"/>
            <end position="1011"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1013"/>
            <end position="1026"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5102828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1177" mass="134737" checksum="D222CF9E3ED7117D" modified="2022-05-25" version="1">MEGFKNLTVDQLIAKLGDLADDEETITILRKECEQLLISASEFLKHKVEDFLIDEGLINNDRAKDVLRAFNFNEVFTDLKTLDQQIAALAAHSGYIYPIDIPLGYRIDQKLDRASGTYIPDLVMETCQYVPVIDTLKLVISNPNVLEAILTEEKSPDGILILQPFLNDLALLEKDDGVLVEMENGNFILRATIAAFFDDGLAVHDVFNLLGPSANQFCRLCMYSRTDLHTGSLEFGPERSKELFDYHLNVLKESNFSDETKTLTGVRGSCCLNDSKYFHISRNKIFDPMHDFLCGICPMIIKLVLKHYIVDKQKLSVENFNNRISSFQWGYCEMKNKPSANFTVSILRRKEHTLSQKAMQIWSLIRAIPFLLSDVIDSDDEHMILVINLLQIMELVFAPKITHSLIPYLDALIREFRSSFKTLFPDVNEINKFHHISHYPKCILWSGPQANYWCMRYEAKHHGAQVRAEVVHNFKNPPKTLIRVFQCGQSAKWGGKNVEMFQVLKSSGKYVLVQETLSQKFLIDLNYDNHNQVFRSNSIKVNSVEFRLGLYTCLESARLRPDNLPLFGVIDEIIVLNNTDVYLLLSICTTCSFDTSLHAYHIECNEDIKTQSFINVLNLAHYKPFSCWNKAECDALYLSLPQRINGNAFIELTKEDLQIMGIKIGPQKLILKVLSSIMTASSTVNDSIIQPPSSSNNNSSIGVKLLLQPEPSTSNTTVIDSTKFSNNSTIRETLSKDSTKQGQKLLKILDDDTQIFSENDRQCLVRIVVADLVNVHKGCYPPTQAKRALAQALVTEFPRLKNNVSENGWEHYFSSDGQKGFIEWRLMTLRSKLKPHEKKYTKSVEKKTPKGLPKPLNSDLENFNRADMDQKVSTLKLKNPNDTNKSLIVSLMDETREFRRYWINTKHPTITEIFEEYPRLLDYNGELIEREFQAMYPKVADNFISLFPTSYMEKILYYVEKNRADLFSKSSSIKDRNLRALLVLVELLPISNAAMSKINKADRKKKAEQQKKIGSKGKKNQKGKKRKLDEMEDDESLVKKNVFPNEFSLRIVPDGTSIKDFARSVATKEKSNVQPYLITQSGQSVDKTFVQGDGWFISVHPESQPITTFDLLYKTYYVLNGEYPETLKNFYNFIDYFIFNMNVESISMVCSLYTSLSNFNIDSRKKGTDDVFENDSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HNW7</accession>
    <name>A0A8J2HNW7_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS12121</name>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS921</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001114">
        <property type="protein sequence ID" value="CAG5074149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5106159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HNW7"/>
    <dbReference type="OrthoDB" id="7706555at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035415605" evidence="1">
        <location>
            <begin position="18"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5074149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5106159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="332" mass="37519" checksum="D39498F9399B48FC" modified="2022-05-25" version="1">MFQITLILFAIIIGTNGKTYNWKDCDETSEIPFKFEVQFSIKTPSKTVKEIETVNRTVKFTIEVTKKIVYSKLLITTTNNGVVTLDRTLAKLNISNKEFISDHFFNSSEHGIVSSVNKIRINSKEGRRYIDYSTNSSDPSWDKIVERRYDNYDNTEHTVLNFKPNGTEIHRTIETGNSDGSITVQHSKETKEGETFVTFEHCVAEINRNNWTSFDQSVSTICGGETKAVVRTIAVSNSQNNSMAIDHFVQEKDVNGGQINERISGIVADNGTVLSSESLESKTNVKRDFAASKGIKNLARVHLKFITLQNIKKELSNIVQKLRKGWSIFSDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HNZ1</accession>
    <name>A0A8J2HNZ1_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 9">Polyprenal reductase</fullName>
            <ecNumber evidence="2 9">1.3.1.94</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HICCMSTLAB_LOCUS13126</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Plays a key role in early steps of protein N-linked glycosylation by being involved in the conversion of polyprenol into dolichol. Acts as a polyprenal reductase that mediates the reduction of polyprenal into dolichal in a NADP-dependent mechanism. Dolichols are required for the synthesis of dolichol-linked monosaccharides and the oligosaccharide precursor used for N-glycosylation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>a di-trans,poly-cis-dolichal + NADP(+) = a di-trans,poly-cis-polyprenal + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:80727"/>
            <dbReference type="Rhea" id="RHEA-COMP:19536"/>
            <dbReference type="Rhea" id="RHEA-COMP:19537"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:231623"/>
            <dbReference type="ChEBI" id="CHEBI:231637"/>
            <dbReference type="EC" id="1.3.1.94"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="8 9">
            <dbReference type="Rhea" id="RHEA:80729"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="9">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6 9">Belongs to the steroid 5-alpha reductase family. Polyprenal reductase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.94" evidence="2 9"/>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5108215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HNZ1"/>
    <dbReference type="OrthoDB" id="5788137at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003865">
        <property type="term" value="F:3-oxo-5-alpha-steroid 4-dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160198">
        <property type="term" value="F:polyprenal reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102389">
        <property type="term" value="F:polyprenol reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006488">
        <property type="term" value="P:dolichol-linked oligosaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016095">
        <property type="term" value="P:polyprenol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001104">
        <property type="entry name" value="3-oxo-5_a-steroid_4-DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039698">
        <property type="entry name" value="Dfg10/SRD5A3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14624">
        <property type="entry name" value="DFG10 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14624:SF0">
        <property type="entry name" value="POLYPRENOL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02544">
        <property type="entry name" value="Steroid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50244">
        <property type="entry name" value="S5A_REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0521">NADP</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="70"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="131"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="173"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="208"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="3-oxo-5-alpha-steroid 4-dehydrogenase C-terminal" evidence="10">
        <location>
            <begin position="182"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00046320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU367081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAG5108215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="326" mass="37825" checksum="622A2ACCDFF3129E" modified="2022-05-25" version="1">MDWNLIKLIFLCFAVLIGISSFLLHCYEKYLPIFIKKSIRHGKYAEKTRHNIAEKFEVPKRSSDSNEASYVLLLCLYELAPLSITALVLCVHKYFFSGNLPEAVYEVLDLLLNSTRKSLGILKLFSWFYNYNLHLTPLDTMIAITLITVQCCKRLYEACYVSVYSEAKMSVSLYIVGFIHYFGTITCIIGESYGFIKGSEYPFHWNELNSIHIIFSICFLLASYEQLRTNFILASLRKNKKGEVVTKSYKIPSGRLFEYVTAPLQLTEIIMYSSLNIILRQSSSFCYIFIWVLANQIETALSSHLWYKKTFKNYPNCRKVLVPFLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HPI0</accession>
    <name>A0A8J2HPI0_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Similar to PACS1: Phosphofurin acidic cluster sorting protein 1 (Homo sapiens)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HICCMSTLAB_LOCUS12412</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PACS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5106742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HPI0"/>
    <dbReference type="OrthoDB" id="28829at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072659">
        <property type="term" value="P:protein localization to plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019381">
        <property type="entry name" value="PACS1/2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057541">
        <property type="entry name" value="PACS1/2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13280:SF17">
        <property type="entry name" value="KRUEPPEL TARGET AT 95D, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13280">
        <property type="entry name" value="PHOSPHOFURIN ACIDIC CLUSTER SORTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25332">
        <property type="entry name" value="C2_PACS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10254">
        <property type="entry name" value="Pacs-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosphofurin acidic cluster sorting protein 1/2 N-terminal C2" evidence="5">
        <location>
            <begin position="60"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphofurin acidic cluster sorting protein 1/2 C-terminal" evidence="4">
        <location>
            <begin position="546"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="225"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="384"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="654"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="225"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="239"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="385"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="407"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="460"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="490"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="674"/>
            <end position="694"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF10254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF25332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAG5106742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="845" mass="93782" checksum="6C7230E3E04C2DCC" modified="2022-05-25" version="1">MVKTYARSLKSSSISLYWLTGSVRRGVRQCVGAVCVIGGRPHGQIMAERTKVTAPTSRPVPMKLFATWEVDRTPPNCIPRLCTLTLTRLVILRPLGADLASISIAVKMQSSKRTLRSNEMAIPSGGILDTELELQFALQYPHFLKREGNKLLILLQRRKRYKNRTMLGYKTLAEGVINMAQVLQKQMDLELELVSDKAEKYGGHSVVLAKVNVIALSSQPVDQDKRLLNDPSERLGPEYSDEEEEFSSEGEAEGSDSEPTLEVHRRKNRNKIPPNARQRNLKQKFIALLKRFRVSEELEHDQEEIGQKLSGGDMEIEELFDELEDLSDSGPELDTMSVSSTPKPSLRPFFSSSRSLLAPPHPVLVGWLCTVAWYNSIVVTREESATNTTTATTTAANVCQSSSGSTVKEKTRVGHTTPERGGDRQSDDSSRRADSDSHPENWTDHEANDAPSTVAGSPPKSEHPQHHQHSNKNENSDRRSRLFARDRGTPGSNKSKKQSLSVDLKPSVELNNSEPRKALVEQLSRVLPDDSLPEAVSLVSLADPGDLLSFRPPDWQSYLRFLIVPLGSNSLAKYLGSIDSKYSMLFGEEWRELLEREASGASEGAARVSEYLLTTGPTLLLPIAEAMVTYRETDDSSQIFIPFVNDVRVGCPDSSTSASVDLEEGAAVSSGSPPSLPPPSLAIPPPGKLTPPSSPNVSQPRDGWEPVELQLDYWSKPSLGDKGKSTLRQAFRALHVQRLPTMGENPGPYLSMNYTTKEKKQKIMRLGKKKEKEKENEPKSQAVDGVTRLICSAKTHNIPWRVTIDGTEWYGVKFFQLSAQWQTHIKTFPVAMLIYNPLQQTASLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HPW2</accession>
    <name>A0A8J2HPW2_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Similar to TTC28: Tetratricopeptide repeat protein 28 (Homo sapiens)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HICCMSTLAB_LOCUS10817</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5102042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="626167at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:001539">
        <property type="entry name" value="AGAP002648-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000040">
        <property type="entry name" value="Tetratricopeptide repeat domain 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000416">
        <property type="entry name" value="Tetratricopeptide repeat protein 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024983">
        <property type="entry name" value="CHAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058900">
        <property type="entry name" value="TTC28_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10098">
        <property type="entry name" value="RAPSYN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10098:SF108">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12770">
        <property type="entry name" value="CHAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13176">
        <property type="entry name" value="TPR_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26117">
        <property type="entry name" value="TTC28_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="26"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="93"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="281"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="481"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="domain" description="CHAT" evidence="3">
        <location>
            <begin position="1293"/>
            <end position="1575"/>
        </location>
    </feature>
    <feature type="domain" description="TTC28 C-terminal" evidence="4">
        <location>
            <begin position="1692"/>
            <end position="1788"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1829"/>
            <end position="1867"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1944"/>
            <end position="1964"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2017"/>
            <end position="2036"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2052"/>
            <end position="2073"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1840"/>
            <end position="1852"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF26117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAG5102042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="2073" mass="225759" checksum="ABB55AFA5E758610" modified="2022-05-25" version="1">MSHRDISEVEPEGTSALAAGSRALFLETVRKSNTACQNGDYALAATLYTEALALDPLSHVLYSNRSAARLKMGLFALALQDAVRATELVSQWPKAYYRQGVALQCLGRHGEALVAFATGLARDPSNSQLLSGLVEASLKSPLRSTLEPTFQQLRAMKLDESPFVVISVVGQELLGAGQYKAAAGVLEAALAIGTCSLKLRGSVFSALSSAYWALNSLDKAINYMQQDLGVARSLGDTQGECRAHGNLGSAYFSKGTYKEALTAHRYQLVLAMKCKDAQAAASALTSLGHVYTAIGDLPNALASHKQCVQLVKQMGDRLQEAREIGNVGAVYLAMGEFESAVDCHTQHLRIARRLGDRVEEARAFSNLGSSHHYRRNFGQAMTYHENVLKIAQELGDKAIETRAYAGLGHAARCAGDLAQAKLWHQRQLDVALTTKDKVAEGRACSNLGIVYQLLGDHDAALKLHQAHLGIARSLGDKAGMGRAYGNIGNAYNALGYYEQAIKYHKQELTISKEVNDRSSEASTHGNLAVAYQAVQGHETALRHYRAHLVIARELKDAAGEACALLNLANCLSSRGRFEEAVPYYENYLMLSQELHDVEGEAKACHFLGYAHYCLGNHREAVRYYDQDLALAKDLQDKSGMGRAYCNLGLAHLALGNLDTALECQKYYLAIAHMMKHLSGKFRALGNMGDCLLRLGETEEAIKIHQRQLNLARQAADRSLEAAAYGALGIAHRATRNFDKALGFHTQELTLRQESSDLRGECRAHGNLGAVHMALGQYTHALKCYQEQLDRARELVDSGIEAQALGNLGIARLNMAYYEDAIGYFEQQLATLEPLTTGTALLDKARALGNLGDCYEALGDPEEAVKCHEQQLAAAIRLRSIIDQEKAYRGLGRAREASGNLQEALVCFEKRLVAAHEVESPEARGSAYGDLGRVHAALGNHEQAVSCLSHQLALARGLGDKVAEAEAASGLGVVHLLMDDPDSAFRHHQLELSLAEDLDAAGLQARACANLGATQEALGQYEEAIKLQEQSLSLAAAAGDQAARAIAFSSLGRLHHLCGDFPRALSYLQSGLSLSEGLGRREEVARLHHRLGLVHWQTGEASIAVEQLEKAANLLESLDGSSSILTNQTKKSDLLVEIYGMLQKVLVSLNRAEEALNWAERSRRSKSINLEDVTHYSEIIDRQRGIVLYYSEVENELHVWCLAPSRGLLRFHSTTMPNGITLEQQVNQAREALLGESPDLIDESSKMPLRGNRFNASSYSLSSLFSVGSASSRAGSARWGRGSKDPAWQTPVSIQSLYDILLAPFEDLLPPVRKELVLVVEKSLYLAPLPALQAASGEDYLCERFSLLVVPSLAALKKRSRTPMPEGGATVAALVVGNPVLPEELRDEHGWPETVASAESEAGIVAEILESRPLTGIEASRSAVLRSLPDAECIHLTIPILWNSASLAFTPDQNEENTQRPEFLVSPAEIMRQKLTARLVVLSSGHCWNNDESSTKITTDGIEAIAKSLLNAGAQCVLIAMWPVPSTAGSILLRAFYSAMLQGARASRALAEAMQTVQHTRHFAHPLNWAGWLLLGGDARLSNKVALMGQALAELLRSGPEMSRDALRVTLHLVEKSLQRIHRGQKNAMYTTQRSIENKVGTATGWKELLMSVGFRFEPAGNGIPSSVFFPQSDPEERLTRCSASLQALLGLGPASLHALVRLLQVPEAAEDVISAMRKASCATEGQEVSLPVKVWRASGSHELFASLGFDLMEVGQSEVTLRSSKQASRRAVQFALQALLALFDTQEAPKSLSLDSGSSMESLVSVSQPEKNSLLERPRLGGAFASYVRHRGEPDGKTNEAPNASIPRQTYPNEGGESDVAFTPSPPVALTLNHQTRIRNLYQEQTVRPDSSSSSSVTDWENGHNTILRRQPVPPLPPAVLDRLSVRTEIGSIASRKLRMPTTNNTNEEINHQPETPQTNESIPHNMRNLATSLTSLTRELTPTMSEVYHERNIGLGLAPSLSKLLEEVGNVTESEQRQLSRSEQSQTQNWLQNEPELCRRDEADGRSIAESQCSATSFNKIHRKAPPPPVNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HQB1</accession>
    <name>A0A8J2HQB1_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Similar to Cow: Proteoglycan Cow (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HICCMSTLAB_LOCUS13017</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5107997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HQB1"/>
    <dbReference type="OrthoDB" id="8875634at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005518">
        <property type="term" value="F:collagen binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050840">
        <property type="term" value="F:extracellular matrix binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00104">
        <property type="entry name" value="KAZAL_FS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00191">
        <property type="entry name" value="TY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.800.10">
        <property type="entry name" value="Thyroglobulin type-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002350">
        <property type="entry name" value="Kazal_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036058">
        <property type="entry name" value="Kazal_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019577">
        <property type="entry name" value="SPARC/Testican_Ca-bd-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000716">
        <property type="entry name" value="Thyroglobulin_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036857">
        <property type="entry name" value="Thyroglobulin_1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13866:SF30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13866">
        <property type="entry name" value="SPARC OSTEONECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07648">
        <property type="entry name" value="Kazal_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10591">
        <property type="entry name" value="SPARC_Ca_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00086">
        <property type="entry name" value="Thyroglobulin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00280">
        <property type="entry name" value="KAZAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00211">
        <property type="entry name" value="TY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100895">
        <property type="entry name" value="Kazal-type serine protease inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57610">
        <property type="entry name" value="Thyroglobulin type-1 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51465">
        <property type="entry name" value="KAZAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51162">
        <property type="entry name" value="THYROGLOBULIN_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0357">Heparan sulfate</keyword>
    <keyword evidence="4" id="KW-0654">Proteoglycan</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Kazal-like" evidence="11">
        <location>
            <begin position="87"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="Thyroglobulin type-1" evidence="10">
        <location>
            <begin position="345"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="429"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="429"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="374"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="383"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAG5107997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="454" mass="51480" checksum="B2A9D67EF11E44D8" modified="2022-05-25" version="1">MALIYFDLRYILKQKSAVGFFSTKVIISVNFIFCSLFQDDTRIMKVGDKKKWIHDPSSELCRPLNCKKKELCLLEDTFTAVCVSKKELHKSGCQECPVVKPNFLCGIDNRTYSSPCRLEYHNCIHHTSVHIACKGFCPCKGGSDLKVHTKKIPPTKLQKNILGKTGRNRDITLTPRDFNYDNHHYQYLKYSKRPKGLGINSKYEDDIKHSMSNEISKNPSTLKPTFDSPEAKFNRLRNTDCPPSSRPAMANRLLDWFSVVMADAKYRRQHSKSKGHFPIGCQPEVRWMFGHLDNDEDRRISLAELYSLEHDQNEPCLKPFLDACDTDGDIFVSGPEWCGCFSKAERPCAAVRRRSSPDVAPACDSRGYYRSIQCHRGLGLCWCVDPHGVEFAGTRTRGSKPDCGKYAIVSKISNDALKTNSVNLENEINDYDDEDDGVDSANDLEGSADQPLDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HQZ4</accession>
    <name>A0A8J2HQZ4_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Similar to Tmem17b: Transmembrane protein 17B (Danio rerio)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HICCMSTLAB_LOCUS13260</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5108483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HQZ4"/>
    <dbReference type="OrthoDB" id="311720at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035869">
        <property type="term" value="C:ciliary transition zone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905515">
        <property type="term" value="P:non-motile cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019184">
        <property type="entry name" value="Uncharacterised_TM-17"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13531">
        <property type="entry name" value="GEO07735P1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13531:SF6">
        <property type="entry name" value="TMEM (HUMAN TRANSMEMBRANE PROTEIN) HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09799">
        <property type="entry name" value="Transmemb_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="41"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="74"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="107"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="142"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAG5108483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="182" mass="21249" checksum="933F3FA94E222793" modified="2022-05-25" version="1">MWRSKVITASNRIFPGLIYHDWEKQYWDAGHLVKSNLPLQMALYFDIWFFPIWFFIILLGLDAKYYNLSGVYKFINISVYLLITCIECLKLYLGYLGNLSEKIPELASFWLISALLQFPLLVFMLLDANILIFFIEKASTGMMVLLLIFEIITGTIALNNIAAHHLKRFYMAQLCGRVNKFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HR43</accession>
    <name>A0A8J2HR43_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Salivary lipocalin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS13729</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5109093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HR43"/>
    <dbReference type="OrthoDB" id="7691981at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012674">
        <property type="entry name" value="Calycin"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50814">
        <property type="entry name" value="Lipocalins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035292486" description="Salivary lipocalin" evidence="1">
        <location>
            <begin position="17"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5109093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="80" mass="9275" checksum="EE6C5E2937B38AC9" modified="2022-05-25" version="1">MLHTIVIFCVTLFAYAEEISPGRCPHVMLDTQLNLSKYQGQWHEYKRSTNIWSNTEKCTSMTYKKIGNRWTVIFAGISSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HSJ3</accession>
    <name>A0A8J2HSJ3_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS12541</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5107011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="7694755at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044389">
        <property type="term" value="F:ubiquitin-like protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050899">
        <property type="entry name" value="DDRGK_domain-containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48176">
        <property type="entry name" value="DDRGK DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48176:SF1">
        <property type="entry name" value="DDRGK DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="176"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="476"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="627"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="816"/>
            <end position="970"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="996"/>
            <end position="1020"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1048"/>
            <end position="1187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1394"/>
            <end position="1501"/>
        </location>
    </feature>
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            <begin position="1592"/>
            <end position="1954"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2055"/>
            <end position="2076"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2275"/>
            <end position="2619"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1290"/>
            <end position="1317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="191"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="210"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
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            <begin position="234"/>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="481"/>
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    <feature type="compositionally biased region" description="Basic residues" evidence="2">
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            <begin position="496"/>
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            <begin position="506"/>
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            <begin position="518"/>
            <end position="530"/>
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        <location>
            <begin position="543"/>
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        <location>
            <begin position="563"/>
            <end position="620"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
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            <begin position="816"/>
            <end position="839"/>
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        <location>
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        </location>
    </feature>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
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            <begin position="1129"/>
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        </location>
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        </location>
    </feature>
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            <end position="1434"/>
        </location>
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            <begin position="1435"/>
            <end position="1450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
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    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
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        </location>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
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    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
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    <feature type="compositionally biased region" description="Basic residues" evidence="2">
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    </feature>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
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    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="2059"/>
            <end position="2075"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="2275"/>
            <end position="2293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="2294"/>
            <end position="2303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="2359"/>
            <end position="2395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="2485"/>
            <end position="2499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="2500"/>
            <end position="2509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="2552"/>
            <end position="2586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="2606"/>
            <end position="2619"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5107011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="2671" mass="305823" checksum="124CD0F97E719DF8" modified="2022-05-25" version="1">MESPGLSDPQQPRDDMSQSSSSVANVDRSETPDSNRGPVDDESAADSPKITKPVLGKVQAKKRLMAFASKFTAPLIQKSSDKGFSFKSRNLNSFQVNKKKLSSSSKDSMEGENIARNKTSIELELSEKIQPDITVTLKSKSSSKKTKKRAEPKIAAIEEIIREAAKEKELLAMQLSEQKARQQQEENNLDDLPRNNGRSDRNKSFGRHQQWGNRRSQNFHNDNFRRGNFNQNYGDRKFNDRRRTFNNEYFRDRSKSRERREREDRERREKEDRVGREREDREKPRRNLFDMDQQFKMKEYKHDNKHFNKNRNYNDHKREKKEEIIERKIKTPWKNFKGQNGRIRERSLSLEINEDSNFLANREVKFKTAQDYNAQLEHMLLIGDHHVKRNCVTVDGINDVKKQYPPESIRVTKKFNVPSLFYSENPKLSLLLPCQQLYQILPPDRCNTMRKIADGTVEPSKEVEYDQGPRTWYKHMHRSRSRDATHEVKDTEKSKFSVRKSKKSKSRWDSGDETMAKVEVPSCSSSQVQSEHSDEENEVTKVQQKDDAENVKSVTKECLETREEVEEEEEEEEEEEEEEEEEEDGELPKEEEEEEEVQDEDLEENDEDEEMEKEDGEAEDEKIILLEKLDSPSESSCSNKMIPEEDLSNKIESDLLVSNEEIQTIETPIEESSSEINAKTLQLVTDNNNDNLIKKVEVGKKLVSEYEEFLKMVGHDEEEEDSIAIDLNFENPSVIKKADVEPEVINQLITNEFIEENTDQDIKITPVMIDSVEENKSLSRSENTSDIIDAKIEKIDETIVIDSEIGGGWENIKEKIKHKKSLRSRKRRERKKKKNRKKVSSSESSDSSFSSSESEAEKRKRKRKRKRRKKRTRDSSSDSSSSDSDASSSDESIKLSKKKKRRRKIKKKLRIKNKKKRLRKESTVSNSSYEFDELTRKRKKRRDSKHRKTSKQRRSKSTEKKKIKVTDERKNEKIENENLEVIIKKDVPQLPHWETEVKKSNVSSIEVSPEVTQIKESSEDKTIPQVIIEAAIAEKLYEVWDNSSNYTQITQPLDDQQPEESKIEETQSEKSEVVNENPTAVEDEEKSIENTEPVHHSPTEKATDVIEITTDTVSDNQSDKKSQRDSSRNKKVKKTKKKRRSISTSSTSSDTSSESSDDVSSKKKSREKRKKKSRSKRRSPSQSELIKKLKKYRAKLTESLDFDALHFPSLTQLEENTETLPIINDWEVDSMDAVEKFITNATKEISAEKSDKKVEKALLYDSKTDMYIPVEKNKTPRENKKKPANRVCSLRIWEDEEEEGEREAKMLMEEKIKIENELQVPDDQLKIETITSPTSTIIEEKKEEEKKVDDISENIVKKEDEEAKTSIEEKSLEWVKNVPECENNAVEILPEQQVPMTTRWTEPSPVLLKEEEEEEELEDDNLVPVNWEEEEIDWENQSSLITGVKSVQTSKNKKESSESSSDSSDTSSSSESSDSDTENVKRSQHNSLDKSKNVSPAVETDAMKKLRMNMFAEFATLESTDNFSQLSDQKINSNVSPFKLSPQQLQLAKSEVKSGESADISVPIFDDTRFVTQTRESDTVVEKGKFRASFQEVRLRSYSRSPEQDSKRSLNSRNDKSKTRSSEDRASSSSYRSSSRGSVKDSSRDRKKVDDKDLKRSSLSADQKKISPLSDRGLKEKRHSPLSWNRSRSRSRSWSRSRSRTPSKRDDKLSWDRQKRMGRVDDRRERFSRSPDRRGRLHRSNESERGRERDRSRDRDWSREKITEKAYDPMEILRGVAHGGDKQRQAALERPLDSLDVNISFSSDLNKSRYRSRSRSRSRSRSRSRERRNRDIDWDRSRESPDSSRSRSLDTRKSSRLSPRSRGSPLRSGRSRYSSRSRSRSWTRSRSRSRSRSRSRSTQRFRSRSRSSSRSRSRLGLRNSDRGQRSLDRSRRSRSFSPEQRKLNTVGGMGYRKSPSKEQIQQIETIIHPPGISSLSHQKPQSISQVNDSNNIPVPTQQFEYSYYPGNNLTYPPRLETTTITTPTMAAATINPPAGSPKRLSLDERLELELGIKKSQESLPPPLPTSLPPPPPPPHTYHLPKYNPPTMQYPPTSVVPVLQPRIPTSLHGPYARPQQPTVLQVGNVLQVVPAEYTSPVPPVGIRNDMPTPPSSTSNNPNRLVRVGNVVQVVPSTTLDWSGPVPPPAPIPSTSSLPMSSVPMAIPVPMPTPVPMPIISSVPPVSHAIIVPVPPATHVQPISRPAQMAALPKLEPPKAPPVLQPIYNYEAIMEVRKKEKEERKQLRDEKRREKERKKLEKMHRRAKRALGQSSSHIATESPVEPDTTVEVEIEEASVSIQPGHSADEDIDEQIPPTLGQSDENLPEDEDEEEEYDEGDVEEDDEEEDEEEIEPEPEIEDESRVVNLSDQQLDIDVPSVNENIDEDSAPNVNVDVTASLPPPPRKGILVPPGLWDERIANGVLDDDSNTASSTADVVQADSGELSTANVSEEKSTEVDPEEKKLRIPRQRRSRKSVQFADGIKPGEGTSPSGGEGDMPSPPPPTPMSLHDPLNEHIRRSRSRKNRKKAKRAKPLKIKKKVKVKIIKLKKPKVTPLTSMLMDDSDDMDDRSPPPPPPGSPPPPHLWPSYLAAYSAILRPVEGTLSPNNIQAPPPPTPLPLLVPPPPLNCPILPCNKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HTZ1</accession>
    <name>A0A8J2HTZ1_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS13467</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5108831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HTZ1"/>
    <dbReference type="OrthoDB" id="7667465at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5108831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="162" mass="18245" checksum="DA6BD5F7BFE16ADD" modified="2022-05-25" version="1" fragment="single">MTFIRRNSLCPCDKKKLPFKSLLAYVVIGLLATEKITATTQFPTISKCHKKNAHVSNLDSVLNTPPMNSTEEIKRANEIKVNQDETFNPDSVLIKPSDRILLPVFNETENTKFISAKRKNSSNQTLINLHKVKPLKVNASELPAARFIPKLPAHQQLKNISK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HUM2</accession>
    <name>A0A8J2HUM2_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS14078</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001710">
        <property type="protein sequence ID" value="CAG5110224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HUM2"/>
    <dbReference type="OrthoDB" id="7686403at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5110224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="108" mass="11816" checksum="FA623AE3176CF23B" modified="2022-05-25" version="1">MACCPTISFIKILQFIVVCCIFGLDIRGKAFSDSSKNETLLNELVDKIPENNITIPLLNIKLNAESIPTEYISTGTVVAYFIIIFVSFVSGLFGSPLTKLPVSICVHC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MC76</accession>
    <name>A0A8J2MC76_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS3759</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5083189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MC76"/>
    <dbReference type="OrthoDB" id="7670546at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032062">
        <property type="entry name" value="DUF4803"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47890">
        <property type="entry name" value="LD24308P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47890:SF1">
        <property type="entry name" value="LD24308P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16061">
        <property type="entry name" value="DUF4803"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5083189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="647" mass="74974" checksum="54C7DB13E3823A9E" modified="2022-05-25" version="1">MILNGRLTLAVRGTEMWDDFKSWPSINHKWHKPKFTSKEQRLKIDVQDFKNSAEIKSQTKELSSSQRNYIDLTVGLYSSNSSILPIIPFFDSQPVITNPPAPIDEVINHPRPITNNDSNREKILESFNKIYKWCKNFDDSTINHLGDVFKSQINWYDQAESLKSKLTNSDAKKEKEDAIFFDIFELIETKFHNQFMDYLMDYDGCNPDTIDRFIGNIIDNKNYQDMIDLINNFITLTSGSNTFLTCDDTPAYEQFYNLYERVLATTSKAYTMLICTFKFRQLRLSNFNLFEREQHITLENFKSSLKEITKSAKYYLGTIDNPIYKSYKNCDPESWKEGEHYIRVKNYVAYYDPSITWDVNRGMTFEYNYSKEKFCPKVNRDYVLPVHNKMSSSCIENKDNKLQKLCACGLSSDIWDSVNTLSLRQFLVDTTKDQFVVKNGIITLEIRQGTMVNGAVDQRTVFWNTSFGFADEPPDVVRLNYHVKTINLDTIELPEGQFVTGIKFEVLTDNHITLVIRGSEMYRDDKVFTSIHDEWHYPPAENPENTRHNFKLEDFKNPAESSLKNNELSRSGQNYVRLTGGVYSRLFNNFAVIPFIDSRAVVSSPPAPLGGLGLFYKGQPGYGGFIALKYILSKYNLNVDERILSIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MFR0</accession>
    <name>A0A8J2MFR0_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Similar to JMJD1C: Probable JmjC domain-containing histone demethylation protein 2C (Homo sapiens)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HICCMSTLAB_LOCUS2501</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001117">
        <property type="protein sequence ID" value="CAG5077566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MFR0"/>
    <dbReference type="OrthoDB" id="1667110at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054503">
        <property type="entry name" value="KDM3AB_Tudor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054504">
        <property type="entry name" value="PWWP_KDM3B"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22988">
        <property type="entry name" value="PWWP_KDM3B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22987">
        <property type="entry name" value="Tudor_KDM3B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lysine-specific demethylase 3B PWWP" evidence="3">
        <location>
            <begin position="73"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="Lysine-specific demethylase 3A/B tudor" evidence="2">
        <location>
            <begin position="152"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="56"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF22988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG5077566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="249" mass="28770" checksum="6EA7BDE453641F8C" modified="2022-05-25" version="1">MTTVLVEYDDVEWHRREWLSPHRDTAFTYFLIEKGVFWAERPDPRQNGLTAIDQYNHNNHTNNNHRINGKSKGSTSANTVPWPAIGFYPLVAREDLHEDMMPVEFINDKKLEFVDYTKLKPFTQQDWELTKGSLPWANAIRRWAEMQDGQRILLTTPSVLVGFRVEVYRAEGTTQWYTAVIVGYNESTKDLTVTDDTVLEEHNEDPRLVQMRLIGDGESIMRGEVVGMTPRRSRSSTGLMTHAIVVKIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MHT8</accession>
    <name>A0A8J2MHT8_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">THAP-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HICCMSTLAB_LOCUS3430</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5081992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MHT8"/>
    <dbReference type="OrthoDB" id="7683421at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006612">
        <property type="entry name" value="THAP_Znf"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50950">
        <property type="entry name" value="ZF_THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="THAP-type" evidence="8">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="367"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="405"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="386"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAG5081992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="663" mass="76853" checksum="EF376FBAF38BB81C" modified="2022-05-25" version="1">MVRSCSLRNCNNSVRQKYRFFLLPSVKKVAKRAAWLQQCDYLLTEPLPTSGNSISLCEVKYGPSVRTILKPTAIPTIFTKNPPRVSDAVELWYEREYKHNNTLSLLNDLTDDSIIYNNDNQDNEVELLEELNDDNGFEYVDVEDTPPKRVKLIRIQRNKMQIATPQGIKIISASCKTQLNNINMAEHTQVEHFEEGLSPPSSNDMENVDDNSSSFVTMSGKRYCLDVDNKQVAFKVSGDGSLGLESLESEHDQAEYDHHPENYNQDPGNYNYIESGNSNFNSNYNYNCYSNKRKVVNSTFKKQHKYEITPVFIKKEIVDDEIDDKSRLRDIMHFNISQTDSIESNEAHEESANEAFDPVLLKNLKTSDHFDNDNDNDNDNRNYIINDDDQLHDDQSQDLDNDIDYSQLIMSASDLQKRVNELEIEKDSIIKKYRRLELKMETFQNNLRTFLNEDQIKLLQSQSPSMNTTSWSAETLKKSAKVRCIVGPRAYEYLRSQEHYPLPSFRTLYRHREISRINDYTDEMIQEHMNATINRVAMVAEESEVSDADEEIDGEEDSEILDVARIKQKVAAQRPEPETEIEQEVLVENNSEPEHIDFDALDPEIEEDEEEQEQEEIDEIEYEPSTRNIVQDILMNIDNDILLPYEDIAAIDEVRYVPEKTST</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MI38</accession>
    <name>A0A8J2MI38_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Similar to CNDP2: Cytosolic non-specific dipeptidase (Homo sapiens)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HICCMSTLAB_LOCUS3565</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="8">Binds 2 manganese ions per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M20A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5082449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MI38"/>
    <dbReference type="OrthoDB" id="7832001at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070573">
        <property type="term" value="F:metallodipeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05676">
        <property type="entry name" value="M20_dipept_like_CNDP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001261">
        <property type="entry name" value="ArgE/DapE_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017153">
        <property type="entry name" value="CNDP/DUG1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051458">
        <property type="entry name" value="Cyt/Met_Dipeptidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43270">
        <property type="entry name" value="BETA-ALA-HIS DIPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43270:SF4">
        <property type="entry name" value="CARNOSINE DIPEPTIDASE 2, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037242">
        <property type="entry name" value="CNDP_dipeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00759">
        <property type="entry name" value="ARGE_DAPE_CPG2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0464">Manganese</keyword>
    <keyword evidence="3 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M20 dimerisation" evidence="10">
        <location>
            <begin position="213"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="106"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="171"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="137"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="137"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="172"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="200"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="7">
        <location>
            <position position="200"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between homodimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="233"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between homodimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="336"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between homodimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="7">
        <location>
            <position position="349"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between homodimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="7">
        <location>
            <position position="423"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between homodimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="451"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="7">
        <location>
            <position position="451"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between homodimeric partners</note>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="9">
        <location>
            <position position="233"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR037242-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR037242-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR037242-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR037242-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAG5082449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="472" mass="52753" checksum="792183A16DFFFE00" modified="2022-05-25" version="1" fragment="single">MAPTIPKALAKLYGYIDEHKKEYVDTLREAVAIKSVSSWPDSRSECVKMMEWMEKKMKALGASTELADIGMEKLHDGREIPLPPILVGSLGNDRSKKTVLIYGHLDVQPALVEDGWDTEPFTLIEKDNKLFGRGSTDDKGPVLCWLHALQAYKAIGEEIPVNVKFVFEGMEENGSEGLDEFLWSRKESFLSDIDYVCISDNYWLGTTKPCITYGLRGLAYFNLEVSCAKSDLHSGTFGGTVHEAMSDLIFLLNSLVDVNGRILIDGIYDKVDKITEAELKSYQDIEFDVDEFRSTVGTKKLAHNEDKIQLLMHRWRYPTLSIHGIEGAFSEPGAKTVIPRKVIGKFSLRIVPSMTPDEVTTKVKAHLEKIWATRGSPNVMNIHMGHGGKPWTENPDHPHYVAARTATKYVYGVDPDLSREGGSIPVTLTFQEVTGKNVLLLPVGCGDDGAHSQNEKLNIRNYIEGVRSIIFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MIY8</accession>
    <name>A0A8J2MIY8_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Similar to MTSS1: Protein MTSS 1 (Homo sapiens)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HICCMSTLAB_LOCUS4944</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5088691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MIY8"/>
    <dbReference type="OrthoDB" id="10061327at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015629">
        <property type="term" value="C:actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009898">
        <property type="term" value="C:cytoplasmic side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005543">
        <property type="term" value="F:phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030031">
        <property type="term" value="P:cell projection assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007009">
        <property type="term" value="P:plasma membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013606">
        <property type="entry name" value="I-BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030127">
        <property type="entry name" value="MTSS1/MTSS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003124">
        <property type="entry name" value="WH2_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15708">
        <property type="entry name" value="ACTIN BUNDLING/MISSING IN METASTASIS-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15708:SF4">
        <property type="entry name" value="FI21477P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08397">
        <property type="entry name" value="IMD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51338">
        <property type="entry name" value="IMD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51082">
        <property type="entry name" value="WH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IMD" evidence="3">
        <location>
            <begin position="1"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="WH2" evidence="2">
        <location>
            <begin position="929"/>
            <end position="946"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="157"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="278"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="376"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="439"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="594"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="690"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="759"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="877"/>
            <end position="910"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="938"/>
            <end position="959"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="287"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="376"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="397"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="411"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="445"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="474"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="523"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="594"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="771"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="877"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="895"/>
            <end position="910"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="943"/>
            <end position="959"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG5088691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="959" mass="104350" checksum="40583F39A500F2A1" modified="2022-05-25" version="1">MDVNVDRDCSALGGLFHQIITDMKNGAPLWDDLISKATKLHTCLKAAILAVSAYLEAFQKIADAATSARGATKEIGTALTRICLRHKAVETRMKSFTCAIMDRLVMPLQEKLEDWKKALIVLDKEHTKEYKKAKAELKKQRTSAVDTLRLKKKTRKITTNHGPGMGTGNISESFQGNKEDDMELNRRLLEPSVADKRISLEETERKAVRAALLEERGRFCHLARLLKPVLDEEIAMLMELTHLQEVSEQLERHTLAPYDLPAQCEQIITDLKERSDSGQWPLHHHLTSTTPPSSPSLSLGSRKSSMCSISSLTSSGSSGSCKNHPSPACGHPHHWHRSFSQPLGGLNTCRSIIIDSGGGYGNNVSKTLMLRRHLSTGSSRDSGFTSQDTLNKQPTEQVSSVSSQSNVSQNANTGSTNINQQQRPLSNATWPNLQETAAGYERQPSKGQTSNERPHTISSAYEKGGHQRPALSVYTFQAPDSTGCHSQPASPVSANTVAVNQARTPPKAGKAANAPRPPIPNRCSSLERSTSTSRVNNDGNGNQRPGKPKLPLPAHLAKELLGNQLVTQPMYVNMHELANLAANRAQEMQVPTVRNSAASSNPNLTEKTESTITPLPKEEAPQQAEMSNLDISGTCTLPRRGSFQQNKPAPPTRRTSTIITSTTSITNTLEERTNCSISASNLLQIAGADSDLTISPSPPNIADETENLPPPPAFLLEGSSPTASPYPPAKRSISVSETVRTLTELRHTPASPSFMRKLMAQQAQPPVTRVTRSGPEHSSSSRRVSTSSIESSSSGHSSSNTTVSNTSTFNSSQQNLISVLSSKLSSTSINSTAGDCSPKLMRKHIISTSELQSQTCSAPRRTSVGFLETLNAKLAAQKQQQRQQQSQQQVPQVQTHLKSTTATLSTPNRSASVRRIMANRVPILDPLQVRDSLMDQIRRGTSLRKTTGTINDRSAPQIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MJQ5</accession>
    <name>A0A8J2MJQ5_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Similar to CA6: Carbonic anhydrase 6 (Canis lupus familiaris)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HICCMSTLAB_LOCUS7953</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the alpha-carbonic anhydrase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5095928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MJQ5"/>
    <dbReference type="OrthoDB" id="429145at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004089">
        <property type="term" value="F:carbonate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00326">
        <property type="entry name" value="alpha_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.200.10">
        <property type="entry name" value="Alpha carbonic anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001148">
        <property type="entry name" value="CA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036398">
        <property type="entry name" value="CA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023561">
        <property type="entry name" value="Carbonic_anhydrase_a-class"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18952">
        <property type="entry name" value="CARBONIC ANHYDRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18952:SF124">
        <property type="entry name" value="CARBONIC ANHYDRASE 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00194">
        <property type="entry name" value="Carb_anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01057">
        <property type="entry name" value="Carb_anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51069">
        <property type="entry name" value="Carbonic anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51144">
        <property type="entry name" value="ALPHA_CA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035194089" evidence="2">
        <location>
            <begin position="21"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-carbonic anhydrase" evidence="3">
        <location>
            <begin position="16"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG5095928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="271" mass="31199" checksum="5A0ED24DF2170F65" modified="2022-05-25" version="1">MNLSNSYIFFLIHLIQSIAANYENSWANKYPNCGGLQQSPINLDKIERDDNHSVSVRFKDYDVVPDSMKVENKGRTVQVTPTWYTTIPAVVKDGVLYEVQQMHFHWVYNNDEGSEHIFEDRKTVLELHIVHWNPALGDFDGQQGEGILVVGLLYEIGIDDEDYSNFLFNILNYAYNIEEPKSGPVYIKPFGLESLFYYNNSTKFLTYIGSLTTPPCSEGVSWVVLNIPSTVNEYQMDLFQNFELHDGDDHNNRPVQKINGRKLTEVPRTDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MJU0</accession>
    <name>A0A8J2MJU0_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Similar to hfw: Protein halfway (Drosophila pseudoobscura pseudoobscura)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HICCMSTLAB_LOCUS4809</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5088350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MJU0"/>
    <dbReference type="OrthoDB" id="10068119at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45617">
        <property type="entry name" value="LEUCINE RICH REPEAT FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035263640" evidence="3">
        <location>
            <begin position="20"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG5088350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="454" mass="52045" checksum="209F573187FF1FEB" modified="2022-05-25" version="1" fragment="single">MHFLSLSICIYGYIAFTSARTEEDQASSPAANTEIRLGIPPPERCFYQDASECPKIENPDDCPCKRIPILSSSNNEEYAVFCCDLNIKTFETGLACSNFPVNVSYIHIRNATLEALNVSEVKWRRLKSLAITDGKINRIKGQFLMMTPTHCLNLSNNALTEIENNSFTRLSQLTSLDLSYNNMTHLPALNIMNGREFWLDISGTNTLWCHDVSQYINKTGDKQIIFNRENETVCSASKTWRWFNTTEQVPLEQVRLLSLLQTECPKGKTWQCQCSFIRLNIVQGEKPVMAVEVDCSGNQLTRLPQRSKFSDNFEFLSLRHNKIKSVPTYILVPNVHNKNHLSHRYVKLGGNKLLCNCNTAKYLKPWLQTNILDPDEVLCENVKEKVVDLEPSKMCVHPGDWTDYIYYLIAFETLMLISLIAKVSYDYWIFKTAGYLPWPANKMPKLPCDWLCEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MLK1</accession>
    <name>A0A8J2MLK1_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS7213</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5093887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MLK1"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5093887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="127" mass="15292" checksum="08EB1333748D109F" modified="2022-05-25" version="1">MKILIKIERSYYLEKIKQNREECIEIVLKDLVYRRALKLPVPTEELKLMDQLIATDRKISDIVNKYNRKVTESYSLSSHNDNDFRYYCYSPIIRRIKYATDRLKLLENLKKISSLRKAIPLSYELRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MLU6</accession>
    <name>A0A8J2MLU6_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Similar to Ninj2: Ninjurin-2 (Mus musculus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HICCMSTLAB_LOCUS7501</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ninjurin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5095022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MLU6"/>
    <dbReference type="OrthoDB" id="6114058at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042246">
        <property type="term" value="P:tissue regeneration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007007">
        <property type="entry name" value="Ninjurin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12316:SF20">
        <property type="entry name" value="NINJURIN-A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12316">
        <property type="entry name" value="NINJURIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04923">
        <property type="entry name" value="Ninjurin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="156"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="201"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAG5095022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="255" mass="28617" checksum="242501EF892B55D6" modified="2022-05-25" version="1">MNLNKVFDNSTNETVIPMEEIPGTHNSQAQKPKEDNVSARSNKNVPINRRPSFFLEAGNRLVPRPVYGSDDVQLYANRNRRSRLEDDPEDYMDVYDTIFDGHGRPSINSGSVVGSVFDVNVYQQKKTLAQGMMDLALISANANQLRYVMQYTNHPFHYLSLAMIVLSLLLQIVVGIGLIWNSRYDVKEDEQIPKANKTNNWTVIGIFLVTILNVFISSFGITDSDSEVGLDLPFTDANGDTIVLRNNDNVTSVIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MMY4</accession>
    <name>A0A8J2MMY4_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS8425</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5096867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MMY4"/>
    <dbReference type="OrthoDB" id="7699669at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5096867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="79" mass="9063" checksum="BAFAAC0A72B354BC" modified="2022-05-25" version="1">MIFCIVPKQNKKILTYRRFSDLNNTALSNSLMLSLNIGRDSLNELDPNSLLDIFLTNVINVLDEFAPLYSRTVFRSLNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MN70</accession>
    <name>A0A8J2MN70_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="2">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HICCMSTLAB_LOCUS8666</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="2"/>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5097355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MN70"/>
    <dbReference type="OrthoDB" id="415023at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd22761">
        <property type="entry name" value="OTU_OTUD6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.80:FF:000003">
        <property type="entry name" value="OTU domain-containing protein 6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003323">
        <property type="entry name" value="OTU_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049772">
        <property type="entry name" value="OTU_OTUD6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050704">
        <property type="entry name" value="Peptidase_C85-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12419:SF10">
        <property type="entry name" value="DEUBIQUITINASE OTUD6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12419">
        <property type="entry name" value="OTU DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02338">
        <property type="entry name" value="OTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50802">
        <property type="entry name" value="OTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="OTU" evidence="8">
        <location>
            <begin position="146"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="82"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAG5097355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="292" mass="33649" checksum="92B2247C20947F6B" modified="2022-05-25" version="1">MSDNENSEDVMLQRHKKERKDLQAQIQILKKSVGKGDKKKKREITEQIAQLESDLDRRQDEELNNLKLSQITLTGLPEETIILPEDDNDNDNDNPKISKAQKRREKKALAERERNQRIIEAEALNVFGKRNVETQTIKKILGERDLMIYEVPSDGHCLYNAVTHQLKSIGVPMRLEELRHKTAEYLRQNINDFLPFLTNPDSEDALTEEQYQQYCDNVATTSAWGGAIELQVLSRILSCPIEVVQAVGSSYIVGDEFESCKKITLTYHRHMYELGAHYNSVTKFVRDDNDDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MP64</accession>
    <name>A0A8J2MP64_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS7652</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5095324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MP64"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5095324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="135" mass="15322" checksum="8970B788DFC00734" modified="2022-05-25" version="1">MCGISARGKESNQSPNNILSPFGHLTALFTMNNLALAQINILSKVDMLSNQEKQKLEQYLCPIVHFPLPSDAIQELPHPCNPFQDYEEDGDQILLALNGFNYQHDVGFTSLDITDPERIMAFIDHIYWSLGCDYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MQ60</accession>
    <name>A0A8J2MQ60_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ubiquitin carboxyl-terminal hydrolase 14</fullName>
            <ecNumber evidence="3">3.4.19.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Deubiquitinating enzyme 14</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Ubiquitin thioesterase 14</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Ubiquitin-specific-processing protease 14</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">HICCMSTLAB_LOCUS5112</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase C19 family. USP14/UBP6 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="3"/>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5089117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MQ60"/>
    <dbReference type="OrthoDB" id="333239at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070628">
        <property type="term" value="F:proteasome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061136">
        <property type="term" value="P:regulation of proteasomal protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02657">
        <property type="entry name" value="Peptidase_C19A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16104">
        <property type="entry name" value="Ubl_USP14_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000119">
        <property type="entry name" value="Ubiquitin carboxyl-terminal hydrolase 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.10:FF:000032">
        <property type="entry name" value="Ubiquitin carboxyl-terminal hydrolase 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019954">
        <property type="entry name" value="Ubiquitin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044635">
        <property type="entry name" value="UBP14-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43982">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43982:SF1">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00299">
        <property type="entry name" value="UBIQUITIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="6" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="12">
        <location>
            <begin position="4"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="USP" evidence="13">
        <location>
            <begin position="106"/>
            <end position="469"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00029877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00032096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CAG5089117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="479" mass="54061" checksum="2420749426850661" modified="2022-05-25" version="1">MPQYKVKVKWGKELFPNIEVNTDEEPILFKAQLFALTGVQPERQKVMVKGMTLKDENWGNIKLRDGVMVLMMGSKEEDVPIEPLEKPLFVEDMNEAEIASALDLPAGLTNLGNTCYLNATVQCLKTVPELREALKKFPGGIASSGSEEIASLVPAQSITASLRDCYEGMDNGIAFRPAVLLQVLHLAFPRFAEKSELGGYQQQDASECWTELIRMLQQKLPARVTASAGEASYKPRSLIEQYFGGTFDTELKCVESEDEPPTKSKEEFLQLSCFISTDVKYMHSGLKNKMQEQLTKMSPTLERDAVYTKTSKISRLPAYLTIQFVRFFYKEKEAINAKILKDVKFPMEFDAFELCSPELQKKLIPMRDKFKELEDKKVEEAQKLTDKKPKVDEPEKAVKTLPFCFEDAVLTHRGRSSSSGHYVGWVRQKGDTWLKCDDDTVSVVTSEEILKLSGGGDWHCAYVLLYGPKILEIPITDSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MQD7</accession>
    <name>A0A8J2MQD7_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS11269</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5102958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MQD7"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="149"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="158"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="178"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="195"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="208"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5102958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="235" mass="26694" checksum="8E9D91BD9C3574D6" modified="2022-05-25" version="1">METKVMQVQPYALISRIDALENYSVCRTKKICFLKDKKYHPIRESPASNRKLYVEENGKFVQIKISKFAETEKELLSIVTRKRIIIKAKKTHSPKENKSKKAKIKEQLGKEKQSAISEKKNIVNSVKRVNDSSDAQYRDELDELLNKTSASEADLDSPLQSQSTLRNSHCSHAKPRSQRTSISSSRSIATDLSHRSSKAQSRHGSKTLPRDQGFDRSLDLNPDRGPDQGLDRSLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MR26</accession>
    <name>A0A8J2MR26_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS11208</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5102836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MR26"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="119"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5102836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="219" mass="24554" checksum="80E13C347ED5115E" modified="2022-05-25" version="1" fragment="single">DCPKTSTSAALKGEIIRLDRFTGVKRSRSRVSSTSSDDTHVSYPTDTDENMMTLSADLDLEEEYYQHIAYNNRHNTNAEESTPLFFDDPDDYYDDNSDDSNDDNTRSFVQSHALGAQYGGVTTRSRAKATQNTLPSTSTAGLPDDHEASIEDNTVEPPGKRFKIEREIIKHYKRFQAKGKETTLTIAEPPVNTDPLQWFHDALSDIVTHITAGCNAHDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MRC4</accession>
    <name>A0A8J2MRC4_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="2">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HICCMSTLAB_LOCUS11436</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="2"/>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5103291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MRC4"/>
    <dbReference type="OrthoDB" id="265306at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02674">
        <property type="entry name" value="Peptidase_C19R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.10:FF:000083">
        <property type="entry name" value="Uncharacterized protein, isoform B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050185">
        <property type="entry name" value="Ub_carboxyl-term_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646:SF23">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE USP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="USP" evidence="4">
        <location>
            <begin position="726"/>
            <end position="1059"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="22"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="98"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="253"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="303"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="389"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="450"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="636"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="23"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="105"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="129"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="158"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="192"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="303"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="313"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="389"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="405"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="472"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="489"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="672"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="704"/>
            <end position="715"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAG5103291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="1073" mass="117334" checksum="57E6C430D705B5F3" modified="2022-05-25" version="1">MSIHRGGPPGAVAVTYNSMAPLSPTRRYSSSSTGPTTSSGTTTTKFNSCRSSKALEHMSYSAAATSTTCLSGARKNYYSPARSVSSYSEAGSVSSAASKLSPKFSSTSTSSASSTASSVSSSNNRDRYNNLSASNNLTDSEFRSKYSPDNYIPTIYRSNGSNSSLSSNSSTLNGHCKSFPTSSSTSGLAELHGGDERDSIGYREQRDRSYSNETTNSLIGGDRWAVNNRHTKRRNNPTNTLLTGHDQIDSAAAPTEVTHHQTSSSSSSLEQDHDSNIIPDIARNNILHHGNNVNNKTAIAVVDNDNNNANNNNDHDRQQQYSDDQHHRSIINNHNDRDYDDNYLNHHGHPTLAGYTQRSYSSVTAATTPAVTTTTTTITTTNTATTLLLSSSPSSSSLSSSTTSHQLTSPVDSPASESYNSTTTTPLATPIASIASVTDNYTFYNTLSSTSATSGDGGGSAAPADNRACSWTKKTPPTNPDNSTELVTNNNDQENSNSRNNPVLKEPTTTGAVFTVGDPMLGSLHSSILSTHLYSVESSNSSTNWMSNDNNDYQQQQRLTSKRDVTNNSDDGFDGIRLELNEYTDDSPLDNNKYLENVKTNSIIEKPQDNNPTRPAYSQVASGFCKVPVDLNTKVTSRPLGTLNDDSGKASNSKTPFDWQKEETLADGARFNPSSSSAGSSTLNPPVGVHQGVSRGINDQIEESSSSRPPRSSRIPTRRDENYGLNGLRNIGNTCFMNSVIQCLSNTKPLLEYLLNEQYLNDINQTTSSMKGALIKAFAQVINELWESSGDHVVNTSSLKNQIQRFAPRFMGYAQQDAQEFLRYLLEGLHEDVNRVAVKPQPILADIPDHFTDSQKATESWKRYLRSEDSTIVDVFVGQLRSSLQCTSCDHISVTLDPFWDLSLPIPTRSGTVKLNQCLEHFTKTEIMDGDEKPTCSKCQMRRKCTKRFSIQKFPKILVIHLKRFSPTERFRSKLSVLVDFPLMGLDLSAFAATGVQGCTYNLYGVANHSGTPYSGHYTAYCKHPYSGEWHEYNDSRVSSVSASSVISSEAYVLFYEQQSQSQQQQQPLSHHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MRJ8</accession>
    <name>A0A8J2MRJ8_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Similar to stc: Protein shuttle craft (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">HICCMSTLAB_LOCUS11692</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NFX1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5103803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MRJ8"/>
    <dbReference type="OrthoDB" id="6512771at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06008">
        <property type="entry name" value="NF-X1-zinc-finger"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="CDD" id="cd16696">
        <property type="entry name" value="RING-CH-C4HC3_NFX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034078">
        <property type="entry name" value="NFX1_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036867">
        <property type="entry name" value="R3H_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000967">
        <property type="entry name" value="Znf_NFX1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12360">
        <property type="entry name" value="NUCLEAR TRANSCRIPTION FACTOR, X-BOX BINDING 1 NFX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12360:SF12">
        <property type="entry name" value="TRANSCRIPTIONAL REPRESSOR NF-X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01422">
        <property type="entry name" value="zf-NF-X1"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00438">
        <property type="entry name" value="ZnF_NFX"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82708">
        <property type="entry name" value="R3H domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="12">
        <location>
            <begin position="421"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="13">
        <location>
            <begin position="424"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="122"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1109"/>
            <end position="1136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="35"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="59"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="132"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="163"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="227"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="256"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="267"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="287"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="319"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CAG5103803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="1154" mass="131130" checksum="50E65AC4FCB17A2A" modified="2022-05-25" version="1">MATWDGSYPGDAQDDRKSYDYSNSQNRVTDDRSWNQDNNQSAPAANYVDNNQPSATYPSSSTELNTSGSSTCYFENNRQFQASSSKTDSNSLVKKSNLHPGASEFIPSGINNHPTELSKAFFSDNRNKNYSRKYDKKNNANYRQDGDYYQRNSFKAYDKSRKNNFTNSNTNNSNNNPFYNYSNDYEPHKDYFDVSFDNKSSNSKDKYNNNNNRRPRSHGRYNNNNNDRYSSANRQSNLNSNDYQSTSNNLENRPRNLNQNSYNYNDNSKDSGDVSQSERHPKGKQTLSRDPRDERYRGFAGDSSDDRQMLKKDKRRGKNNKDFYNDPREERYRNSSRRKGDYSDYYEEKGYREKNHRDNKSEVRQFREENVGKDDFVQEDKLNNWRLKNSPIKKNISKKKMELDDAATQKECLTEQLNRGHLECLVCCENIRQNDAVWSCSNCYHVLHLKCLKKWAESSQSESGWRCPACQNINLVIPEDYYCFCGKSRDPEWNRQDVAHSCGEVCGRTQAKNNCLHKCTLLCHPGSCPLCLVMVNRSCGCGKTSQSCKCSTDSQLSCSATCDKLLNCEKHKCEKTCHHGNCEACDEKVEQNCHCGKKSRFVECLKNTEPFYSCGEACNNLLDCGNHNCSDICHPGPCGSCSLNTELVTHCCCGQTPLTIKRANCLDPIPTCDKICSKKLKCGQPSSPHSCKALCHVGDCPPCDLTTWVKCRCGNMDREIPCCDLTTKADDARCEKKCPKKRSCGKHKCNQLCCIEIEHICPLPCSKTLSCGKHKCELTCHKGRCHPCYLSSFDELYCECGAAVIFPPVPCGTRRPTCSQPCSRQHSCGHQVLHNCHSEASCPPCTVLTQKWCYGKHELRKAVPCYFNGISCGMPCNKPVRCGRHKCITLCHPGACEKPKQVCVQPCTVPREICGHNCAAPCHDGKCPDTPCKEMVKVTCTCGNRSMTRACAENSREYQRIASGILASKMIDMQLGHSVDLEEVFGQGARKQNQLRTLECNEECRTIERNRKLALGLQIVNPDLRGKLMPRYSEYMKQCAKKDPPLCKMVHDKLTELVQLAKISKQKSRSYSFDSMNRCKRQFVHEYCEHFGENGQRKVPRPLLNSVKTATPGSSEVLPSTASKSQKLPTPTWSTSKSTELEIDYFDYPNPKWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MRK2</accession>
    <name>A0A8J2MRK2_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS8544</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5097105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MRK2"/>
    <dbReference type="OrthoDB" id="10368017at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5097105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="286" mass="33615" checksum="CCA1CA4877C0ABA4" modified="2022-05-25" version="1" fragment="single">MLKQPCLSLESLQLYSYQQIWVKKGKKLTSLPLSYFDTNDLGIPKYYLSNRYIYGLVQVCRVIKSSELNIKVIDKSDLPNIKLGVYEKVLSNSTAVFRLKQHNETHYVSSIITGNCIYQVYVNRHKFCNTATNFNPQKIDTFFESSVNQSFIMSANNNQSIDDWINDYYTQSDLYYSLHSFSNFSKQTQLEIFNHLGNEVVINLELRPLLKLPRTKNKIRRMNHHKSLNQLQIGDIIDIKDLEKTDSHLNVDHKLYELFQHYSAIPFINYNFTDCINYKNSEEIDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MSU9</accession>
    <name>A0A8J2MSU9_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Similar to DDO: D-aspartate oxidase (Homo sapiens)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HICCMSTLAB_LOCUS12945</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DAMOX/DASOX family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5107841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MSU9"/>
    <dbReference type="OrthoDB" id="2015447at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003884">
        <property type="term" value="F:D-amino-acid oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019478">
        <property type="term" value="P:D-amino acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006181">
        <property type="entry name" value="D-amino_acid_oxidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023209">
        <property type="entry name" value="DAO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11530">
        <property type="entry name" value="D-AMINO ACID OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11530:SF17">
        <property type="entry name" value="RE49860P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000189">
        <property type="entry name" value="D-aa_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51971">
        <property type="entry name" value="Nucleotide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00677">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="7">
        <location>
            <begin position="2"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="220"/>
        </location>
        <ligand>
            <name>D-dopa</name>
            <dbReference type="ChEBI" id="CHEBI:149689"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="276"/>
        </location>
        <ligand>
            <name>D-dopa</name>
            <dbReference type="ChEBI" id="CHEBI:149689"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="306"/>
            <end position="311"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="307"/>
        </location>
        <ligand>
            <name>D-dopa</name>
            <dbReference type="ChEBI" id="CHEBI:149689"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000189-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG5107841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="335" mass="37773" checksum="39F8A4AB8A7BE726" modified="2022-05-25" version="1">MKIAIVGGGIVGLTTALKLHREFRNSEITVVAENYDDLVSHIAAGFFRVGHTYSGPTEEITKKWISDSYSYYTEISKKFEPIQAGIAESEAYMFSSFNPDIVQNKLMEQVVPIYRKTTDEEFNLINKNSKYGCYFSTILIQNQYHLPWARNKLKEEGTNLVTKTIKSFNELVDYDFIFNCSGLGAKKLCNDKKMIPIRGQVIKVYAPWVKATFYNETDTYIIPGIDGTCTLGGTRNFETFRKTVCPYDAKSIRERCEELLPSLSKAKTLKHAVGLRPHREGGVRVEIEKISNDRGKAVIVHNYGHGGYGVTTAPGTAQYAIELVQNYHKSSNSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MT92</accession>
    <name>A0A8J2MT92_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Gamma-tubulin complex component</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HICCMSTLAB_LOCUS9331</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Cytoplasm</location>
            <location evidence="1 5">Cytoskeleton</location>
            <location evidence="1 5">Microtubule organizing center</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the TUBGCP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5099994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MT92"/>
    <dbReference type="OrthoDB" id="78652at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000930">
        <property type="term" value="C:gamma-tubulin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000922">
        <property type="term" value="C:spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043015">
        <property type="term" value="F:gamma-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051011">
        <property type="term" value="F:microtubule minus-end binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031122">
        <property type="term" value="P:cytoplasmic microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007020">
        <property type="term" value="P:microtubule nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051225">
        <property type="term" value="P:spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1900">
        <property type="entry name" value="Gamma-tubulin complex, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007259">
        <property type="entry name" value="GCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042241">
        <property type="entry name" value="GCP_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041470">
        <property type="entry name" value="GCP_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19302">
        <property type="entry name" value="GAMMA TUBULIN COMPLEX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19302:SF27">
        <property type="entry name" value="GAMMA-TUBULIN COMPLEX COMPONENT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17681">
        <property type="entry name" value="GCP_N_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3 5" id="KW-0493">Microtubule</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gamma tubulin complex component protein N-terminal" evidence="6">
        <location>
            <begin position="2"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF17681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAG5099994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="424" mass="49323" checksum="007108AC8BE788E0" modified="2022-05-25" version="1">MLHELLLALWGYPTSLGEIFKNDAILLDKYFHPSERGLIKQILKIADDFNNIKKFIKIYSTAHADLENANEQDPLNRGLYLQALCNGMDQALEPFRTEIVELEKCIAKNAHTPATVILSRVENYKFLFNILNNIIRKIKTQRIHGCSLLQCIYELMNTEIIEVKVALQKMMQSLHMIFYKQLTSWLLYGRLEDTYKEFFIQKKETAQESLLFADNKDGSGEIKNHNDMWNYDIDVNMLPSYITFTLAAKILSIGQTIIIFGNDPRGGKDFFVTDKPASTVWGEKEHEYFKKLRSLQMKPVFNVIEFENTIDELKKCVTKLLWHIVVEDAQLLQQLKYIKDFYLIGRGDLFLDFIKLTSHILSKPPTNHTSRDLNVAFRMAVRKIMLNDEGAIDDFNFSVPRYWCATTKKQFNIHSRQPPILFAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MTJ1</accession>
    <name>A0A8J2MTJ1_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Carbohydrate sulfotransferase</fullName>
            <ecNumber evidence="9">2.8.2.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HICCMSTLAB_LOCUS12690</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Golgi apparatus membrane</location>
            <topology evidence="1 9">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the sulfotransferase 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.8.2.-" evidence="9"/>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5107320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MTJ1"/>
    <dbReference type="OrthoDB" id="2019940at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008146">
        <property type="term" value="F:sulfotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016051">
        <property type="term" value="P:carbohydrate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018011">
        <property type="entry name" value="Carb_sulfotrans_8-10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005331">
        <property type="entry name" value="Sulfotransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12137">
        <property type="entry name" value="CARBOHYDRATE SULFOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12137:SF54">
        <property type="entry name" value="CARBOHYDRATE SULFOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03567">
        <property type="entry name" value="Sulfotransfer_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="8 9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 9" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <keyword evidence="9" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035172516" description="Carbohydrate sulfotransferase" evidence="11">
        <location>
            <begin position="24"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="29"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="29"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU364020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAG5107320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="355" mass="41084" checksum="9A058EA53ED7717D" modified="2022-05-25" version="1">MIQWRVMKIILITIHLMFTFVHLETNNNNNNNNNNNNNNNNNSNSVVNNNNDGLSTTFQRHKPAYSSIGSNALVRSALIERQEKLQYNCEDIMTTKQVNERILVPDDFRNILVNDELELLYCYVPKVACTNWKRVLMIATGKWSGSNPLEIPGNLTHAAGTFKRLSNFTMTEIERKLSNYDTLIVVRHPLERLLSAYRNKFEAKDEISAKYFQTRFGRRIIKSYRRNPSKESLAKGDDVTFSEFVDFITDKNMNGTSNEHWKPIYQLCLPCDVNYNLISKYETLAEDAMEILERIGAGSLTFPMRASSNEPTAGKLEHYYSMLTYKQMKKLAKMYKMDLKLFEYTLEPVLGFSLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MTM8</accession>
    <name>A0A8J2MTM8_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Similar to lmo4.1: LIM domain transcription factor LMO4.1 (Xenopus tropicalis)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HICCMSTLAB_LOCUS13661</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5109025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MTM8"/>
    <dbReference type="OrthoDB" id="6352355at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09386">
        <property type="entry name" value="LIM1_LMO4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050945">
        <property type="entry name" value="LMO_RBTN_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45787">
        <property type="entry name" value="LD11652P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45787:SF13">
        <property type="entry name" value="LD11652P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00478">
        <property type="entry name" value="LIM_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0440">LIM domain</keyword>
    <keyword evidence="1 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="LIM zinc-binding" evidence="7">
        <location>
            <begin position="150"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="9"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="26"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="55"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="92"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG5109025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="211" mass="21735" checksum="0111E7E23E4F117E" modified="2022-05-25" version="1">MNPHHPGHSAAYPHHPSLSSSPHHPGAGGPHHGGYGTPGGGNSGGGSGAGGASSGAGSNSTSTPDLPSPHSPLSHSGQGDPGTPYGSMSGTPGMGSNGHLHGGGGGMMGENPHHSVHTHPHLPGHPAYPPVNHNNNNCSLKQEPGVTPIHQCAGCGGMINERFLLHAMERYWHNNCLKCNCCHRPLADLGTSCYYKNNMILCKPDYMNKLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MXX9</accession>
    <name>A0A8J2MXX9_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Defensin1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HICCMSTLAB_LOCUS12098</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5106102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MXX9"/>
    <dbReference type="OrthoDB" id="10038290at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042742">
        <property type="term" value="P:defense response to bacterium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006959">
        <property type="term" value="P:humoral immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21806">
        <property type="entry name" value="DEFL_defensin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.10">
        <property type="entry name" value="Knottin, scorpion toxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001542">
        <property type="entry name" value="Defensin_invertebrate/fungal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036574">
        <property type="entry name" value="Scorpion_toxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13645">
        <property type="entry name" value="DEFENSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13645:SF0">
        <property type="entry name" value="DEFENSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01097">
        <property type="entry name" value="Defensin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57095">
        <property type="entry name" value="Scorpion toxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51378">
        <property type="entry name" value="INVERT_DEFENSINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035239087" evidence="4">
        <location>
            <begin position="20"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="Invertebrate defensins family profile" evidence="5">
        <location>
            <begin position="65"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAG5106102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="113" mass="12252" checksum="BF9E53A9335DCCD0" modified="2022-05-25" version="1">MKLLIEFIFASCLIASISAAAVPNRLFERDVASDYAEPVASEIDELGPAASEIDAQGPELVRERRLTCDLFSFQSQWVSPNHSACAAKCIAQGKRGGSCSNGVCNCRGRWWGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2N029</accession>
    <name>A0A8J2N029_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Similar to TNS4: Tensin-4 (Bos taurus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HICCMSTLAB_LOCUS13222</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5108408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2N029"/>
    <dbReference type="OrthoDB" id="10013007at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00173">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.10">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000980">
        <property type="entry name" value="SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15832:SF2">
        <property type="entry name" value="SH2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15832">
        <property type="entry name" value="SHC (SRC HOMOLOGY DOMAIN C-TERMINAL) ADAPTOR HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00017">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00401">
        <property type="entry name" value="SH2DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00252">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55550">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50001">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0727">SH2 domain</keyword>
    <feature type="domain" description="SH2" evidence="3">
        <location>
            <begin position="343"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="55"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="212"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="275"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="74"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="88"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="153"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="217"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG5108408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="476" mass="51564" checksum="2EDC43106D073F6D" modified="2022-05-25" version="1">MFINSYAEELNTIVGNAFRMAYVAQLQRQPIIQDVISPQSTTIYRKDSAQEQKNVWNKPLGGDNNSKENKVISGSGGGGGGLVGGCRTPSSNSWLKSRSAPTSRSGNGTSTADMNVQLGSAGSPTLRLASVKTPNSIPGLRPSHPFSNVLGPLTNQDDPKSISQQSTPSSDESNSPTELNSYKRLTDKPPLIKRLTMGLTGGVLGLNSEDDSCPLVSGSSTPTSPTNRPHSGGYINEAIIDNEATRTTYNKIPASDNIDNTINVSITTKNFNIENNRLAPDNSPNSGDTDFKTKRRSQISTSSSSVPADGSTHGSTPTPPPLPERTDSLNNRCEEGELRKAPWFQAGIPREITLEVLSQEPEGAFMVRESTSKPGCYALSLRVPRDFQPSGIAHYLIMRTNKGYKIKGFTKEFTTLTALITHHSVMKELLPCPLSLSRYNPSFVKTDSNKDFADIDSDPDYNTLADFRKMMADLNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2N0P5</accession>
    <name>A0A8J2N0P5_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Odorant receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HICCMSTLAB_LOCUS13799</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Cell membrane</location>
            <topology evidence="1 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the insect chemoreceptor superfamily. Heteromeric odorant receptor channel (TC 1.A.69) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5109163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2N0P5"/>
    <dbReference type="OrthoDB" id="7548151at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005549">
        <property type="term" value="F:odorant binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004984">
        <property type="term" value="F:olfactory receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004117">
        <property type="entry name" value="7tm6_olfct_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21137">
        <property type="entry name" value="ODORANT RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21137:SF35">
        <property type="entry name" value="ODORANT RECEPTOR 19A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02949">
        <property type="entry name" value="7tm_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 10" id="KW-0552">Olfaction</keyword>
    <keyword evidence="8 10 11" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="9 10" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="45"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="128"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="167"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="192"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="259"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="287"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU351113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAG5109163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="387" mass="44360" checksum="29CA97B36F08DE55" modified="2022-05-25" version="1">MMVKNKLEYDKFKTFIRRLLSLVGAWSTEESNLFARSLLYLHLSVYVVPVIGVFNFVGVNILNIKVVAKGLSILMGFSTNILKAVCILINQKDVIELHKFLDSYFDTMVKKPELSKIVLKGVGSFRRLTIIGTVLTTIVCFCYAAYPVLSVINQWHQHTKPIQYKHVFPLIYPWNYMTNSFIYYLHIFNENLTSFSLIVITSGIDGLFLYYIFHLIGMVREISFLISSLDKNDNSEAVMKQCIFKYELLLKCREKIQKIFGLIVLWNMKTNSLTMCINIFQLSNAKSIPLISVILCLALTSLKLIQAFVLGWTGTCFTTESEKLREAIYAADWLGNKQMMNSILIMLTQKPLVIIACKYATVSIEMFSAVINTTISYYLLLKTFDID</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2E7Y7</accession>
    <name>A0A8J2E7Y7_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS2259</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001117">
        <property type="protein sequence ID" value="CAG5076719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2E7Y7"/>
    <dbReference type="OrthoDB" id="10560893at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5076719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="99" mass="11827" checksum="0A71852E1E1F0380" modified="2022-05-25" version="1">MRKLLKEETTDRFNEKSKAYNLRRNYPDDIVDENNVELRLRLDQGKFENKISELGDNSCFSAARIYACLVNKYETYNNYIDYLEKYAEENKIVDLISIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2E8J3</accession>
    <name>A0A8J2E8J3_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribosomal protein L15</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HICCMSTLAB_LOCUS308</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eL15 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001114">
        <property type="protein sequence ID" value="CAG5073364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2E8J3"/>
    <dbReference type="OrthoDB" id="10255148at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1120.10:FF:000001">
        <property type="entry name" value="Ribosomal protein L15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1120.10">
        <property type="entry name" value="Ribosomal protein l15e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024794">
        <property type="entry name" value="Rbsml_eL15_core_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000439">
        <property type="entry name" value="Ribosomal_eL15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020925">
        <property type="entry name" value="Ribosomal_eL15_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012678">
        <property type="entry name" value="Ribosomal_uL23/eL15/eS24_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003269">
        <property type="entry name" value="PRK04243.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11847:SF4">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11847">
        <property type="entry name" value="RIBOSOMAL PROTEIN L15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00827">
        <property type="entry name" value="Ribosomal_L15e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01384">
        <property type="entry name" value="Ribosomal_L15e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54189">
        <property type="entry name" value="Ribosomal proteins S24e, L23 and L15e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01194">
        <property type="entry name" value="RIBOSOMAL_L15E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="109"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="199"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAG5073364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="242" mass="28163" checksum="54F73F70FC61D730" modified="2022-05-25" version="1" fragment="single">PGEISISHLTQKNTSKIKHSLEFLLDFSSEYVSCWVVTMGAYNYITELYRKKQSDVMRFLLRVRCWQYRQLTKLHRAPRPSRPDKARRLGYKAKQGFVIYRIRVRRGGRKRPVPKGATFGKPKSHGVNELKPSRKLQSVAEERVGRRCGGLRVLNSYWVAQDSSHKFYEVILIDPFHPAIRNDPKINWLCKPVHKHRELRGKTSAGKSSRGLGKGHRYSQTIGGSRRAAWLRRNSLSLRRKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2E8U8</accession>
    <name>A0A8J2E8U8_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS473</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001114">
        <property type="protein sequence ID" value="CAG5073530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2E8U8"/>
    <dbReference type="OrthoDB" id="7551508at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5073530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="268" mass="31251" checksum="D00A152B54E3064A" modified="2022-05-25" version="1">MTENTKEPTKIARLSGTRWLARISAISTMLDQWEPLKQHFQIAKEKERCYTAEQLHSMFEDDKNLIYLTFLKTYLKKVTSLNELFQKDQVECLKLFEDLNDLLYDILQVIVVPQQLAKMNRKDLSGYNFQAYIMAVNHMNFGYAVTKACDDAYIKATKDLTDRQQKNLVSQKFYNDIHGIKERFKLFLVTLGCELQKRVPKNIDILKTMSLFSIQDMNLTFPKDISGIVSTFENISGGTVDDIVSEWNLVHKIQIEATTTDEFWSRFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2EC99</accession>
    <name>A0A8J2EC99_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS1366</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001116">
        <property type="protein sequence ID" value="CAG5075212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2EC99"/>
    <dbReference type="OrthoDB" id="7617070at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579">
        <property type="entry name" value="F5/8 TYPE C DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579:SF1">
        <property type="entry name" value="F5_8 TYPE C DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5075212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="456" mass="52690" checksum="D0EC89C939C34B50" modified="2022-05-25" version="1" fragment="single">TSNLFFNPEGDDCSPDDDDPDSDSDSSHSDRLSSSDERDSESDHEEINEPLNSPLYNGSPITIGESILSLLMLVIRHKISHVLLTDIIKIISLHCPIPNFFPRTLYKFRKFFSEFGLPIRRHYFCSICFSKLENSTSNIEKCKDAKQCYFIELPLIAQLLRLFKREGFYNLLNTRFDRQHDPLKIKVIFGMVKFIKILVLRINFYQTAITSLSRGIRMELIYINHPNSLSFSLRSQLKNVLIAGFWFGPTKPKANVFMNSFRQRIENIYSGIFVRIPNHPNAIKVRGMIICGTCDLPAKTCFLNMKGHNGIYGCCKCKIKSQKEGKTRVFPYEEQMNPRATEETVQQGERAFETGESVEGVKGPTTLSKIVLDFIDTTSIDSMHCVFLGIVKQLMRLWLDSKFHKSTFSLRGHINYINQTIKNINPPSFTHRLPRSVSDFKYWKASEMKYWLLYYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2EHH7</accession>
    <name>A0A8J2EHH7_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Similar to NIFK: MKI67 FHA domain-interacting nucleolar phosphoprotein (Bos taurus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HICCMSTLAB_LOCUS1793</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001116">
        <property type="protein sequence ID" value="CAG5075653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2EHH7"/>
    <dbReference type="OrthoDB" id="21467at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12307">
        <property type="entry name" value="RRM_NIFK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46754">
        <property type="entry name" value="MKI67 FHA DOMAIN-INTERACTING NUCLEOLAR PHOSPHOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="6">
        <location>
            <begin position="95"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAG5075653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="267" mass="30434" checksum="B309FF50DE9174EE" modified="2022-05-25" version="1">MKTNNNKMGVKSSGKTTESTLSKAVKNVKEILIKNTEAKEKKQKKLSKSSKEENIIKLKSEDSPAAAAISKKSSKILKKLTKSKSADPEIEKERGVVYIGHLPHGFYEEQMRVFFSKFGEVTNVRVSRSKVSGKSRGYGFIEFAHAQVAKIAAESMNNYLMFGRLVKTEYIPPEKQHDWYFRGLSYTRRSFPKLWNRRLHVQRINGKILGKDPVKDIIVSKIDKSSGEEKETRDLEVRKKLWSLNLLASRLKKKGVKIDMKLGDVSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2EHX4</accession>
    <name>A0A8J2EHX4_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">receptor protein-tyrosine kinase</fullName>
            <ecNumber evidence="2">2.7.10.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">HICCMSTLAB_LOCUS2066</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13 20">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.10.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.10.1" evidence="2"/>
    <dbReference type="EMBL" id="CAJNRD030001116">
        <property type="protein sequence ID" value="CAG5076085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2EHX4"/>
    <dbReference type="OrthoDB" id="3256376at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004714">
        <property type="term" value="F:transmembrane receptor protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007169">
        <property type="term" value="P:cell surface receptor protein tyrosine kinase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902533">
        <property type="term" value="P:positive regulation of intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd11304">
        <property type="entry name" value="Cadherin_repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00192">
        <property type="entry name" value="PTKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000190">
        <property type="entry name" value="Proto-oncogene tyrosine-protein kinase receptor Ret"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000678">
        <property type="entry name" value="Tyrosine kinase receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050122">
        <property type="entry name" value="RTK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416:SF621">
        <property type="entry name" value="TYROSINE KINASE RECEPTOR CAD96CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 18" id="KW-0418">Kinase</keyword>
    <keyword evidence="10 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-0675">Receptor</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 16" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="11" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035301217" description="receptor protein-tyrosine kinase" evidence="16">
        <location>
            <begin position="18"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="187"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="17">
        <location>
            <begin position="276"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="311"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00051243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="CAG5076085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="575" mass="64927" checksum="03A271D3EBB4C4C7" modified="2022-05-25" version="1">MIIRWIIVVALATFTYGQLSDNTPPVMILDRNWILLDSAPKGTFVTRVHAKDNEQDQLNYGLEALDHNFNGDFAGSGSTTLPFFINSLTGEIVTNDTLKGRSMRSPFLAHFSNSQLPSFPRPVNSTNTQEKTTVLRPAEINISNYVNQVINGSSMTSGPSVYNTSTLDSLSVQDSTYSYKNITMTTVGTISAIVAVILIVGMALWSVRRKICSHKKSKHPKELAVKVSDMSSSNEPSLILKNFHNYKFSSNKYQEWNKSSKESTKKDEWEFPRHRLKVFCILGEGCFGQVWKCEAIDINGSGIGVSVVAVKTLKENATERERIDLAQELTVMKTLEPHPNVVRLLGCCTEREPIFVIMEYISGGKLQSFLRNMREEKNSGRPGLTSRDLTGFVHQIAKGMAYLASKGIIHRDLAARNILIDSNRLCKIADFGFARDIAANKIYERKSDGRLPIRWMAPESLYDNMYSVKSDIWSFGVLTWEIVTLGSTPYPGMGAAEVMRKIKEGYRLERPEHCKRELYNIMYYCWDKDPSCRPSFSELVAMAEGLLLDEIDYIELDRFPDHSYYNVLNLSGEKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2EIE9</accession>
    <name>A0A8J2EIE9_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS2398</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001117">
        <property type="protein sequence ID" value="CAG5077204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2EIE9"/>
    <dbReference type="OrthoDB" id="8963429at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5077204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="210" mass="25401" checksum="5E0D8B516459D7EB" modified="2022-05-25" version="1">MYHQENLKKVRVILKRNNYPTKFIDCSINKFKSKHMDDRRDNLRADKQENRFRFPYIRGLSQNIMRCFRVTDWKPAFYNIKKVGDIYTSLKDKVKLRIGPRLFTKLIVVVACVHRVYQHRYSCEEKNKDKENQTALAAHHFSSDHNFDFENVKIIDSESNWWKRNISEMVQICLHDTVNCKPDTENLNCMYHGLIEKFKCNRKHPRRQME</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2EIK1</accession>
    <name>A0A8J2EIK1_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">phospholipase A1</fullName>
            <ecNumber evidence="4">3.1.1.32</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HICCMSTLAB_LOCUS743</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 2-acyl-sn-glycero-3-phosphocholine + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18689"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="ChEBI" id="CHEBI:57643"/>
            <dbReference type="ChEBI" id="CHEBI:57875"/>
            <dbReference type="EC" id="3.1.1.32"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the AB hydrolase superfamily. Lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.32" evidence="4"/>
    <dbReference type="EMBL" id="CAJNRD030001114">
        <property type="protein sequence ID" value="CAG5073971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2EIK1"/>
    <dbReference type="OrthoDB" id="199913at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008970">
        <property type="term" value="F:phospholipase A1 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017171">
        <property type="term" value="F:serine hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00707">
        <property type="entry name" value="Pancreat_lipase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000076">
        <property type="entry name" value="phospholipase A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013818">
        <property type="entry name" value="Lipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033906">
        <property type="entry name" value="Lipase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000734">
        <property type="entry name" value="TAG_lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11610">
        <property type="entry name" value="LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11610:SF173">
        <property type="entry name" value="LIPASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00151">
        <property type="entry name" value="Lipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00821">
        <property type="entry name" value="TAGLIPASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="Lipase" evidence="9">
        <location>
            <begin position="69"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAG5073971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="351" mass="39891" checksum="E08BA5BC4DC8F056" modified="2022-05-25" version="1">MSLTIPRKFFFIAIGFIILNYVKCLSLQFSDIKDLINEKNLIDTLDPLLLKNANGLILNDALEATLILDQDVQFHLFTKENPDFEYPLKIHDNSNLNDSPFNNNVSTKIIIHGWTDSVHSNWIKELRNNYLLTDNYNIICVNWYPVSAKEYRIAEKLTRQIGEYIGDFIDYLKINSNISLDTVHILGHSLGAHIAGFAGSKLFGEIGRITGMDPARPLFEAPILKDTSDRLDFSDANFVDIIHTCAGTVGFVKPIGHADFYPNGGTYRQPGCPVFITQYCSHGKSHQYMAESIIHPEEFVAVKCDSWKDYKANKCYDNTTAIMGEYISTDTHGIFFLETKPDFSLIKYFMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2EJE6</accession>
    <name>A0A8J2EJE6_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS1255</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001116">
        <property type="protein sequence ID" value="CAG5075084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2EJE6"/>
    <dbReference type="OrthoDB" id="7695744at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5075084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="104" mass="12117" checksum="007EB0B79258AF23" modified="2022-05-25" version="1">MKLSVSAYRAQASAHKKILCNYQHQLSYGATTHQSSTARTPSDPAALLSGLKLKIWMIQLTPRARNRRKCKINKWFRIFKIRRKKNFFDPLTHTNFTLAKCNRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2EMY8</accession>
    <name>A0A8J2EMY8_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similar to Mob2: MOB kinase activator-like 2 (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS1180</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001116">
        <property type="protein sequence ID" value="CAG5074969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2EMY8"/>
    <dbReference type="OrthoDB" id="8170117at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.30">
        <property type="entry name" value="MOB kinase activator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005301">
        <property type="entry name" value="MOB_kinase_act_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036703">
        <property type="entry name" value="MOB_kinase_act_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22599">
        <property type="entry name" value="MPS ONE BINDER KINASE ACTIVATOR-LIKE MOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03637">
        <property type="entry name" value="Mob1_phocein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01388">
        <property type="entry name" value="Mob1_phocein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101152">
        <property type="entry name" value="Mob1/phocein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="1">
        <location>
            <position position="77"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="82"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="157"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR605301-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5074969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="223" mass="25459" checksum="91155CB91935FADE" modified="2022-05-25" version="1" fragment="single">LLIFFRKARRKEKDAGTTEDPKLYLEEAALERQLPELDLRMLVDLPPGLDYNEWLASHTLSLFDHINLIYGTISEFCTQTGCPDMTGPGLRTYLWFDEKGKKTRVAAPQYIDYVMTFTQRTVSDETIFPTKYANEFPSSFESIVRKILRLLYHVVAHIYHCHFREVALLGLHAHLNCVFAHLTLLNQRFNLIDPKETEILGDLEAALLGDSASSVPEPTTVAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2END9</accession>
    <name>A0A8J2END9_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS1555</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001116">
        <property type="protein sequence ID" value="CAG5075401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2END9"/>
    <dbReference type="OrthoDB" id="7701249at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="110"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5075401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="133" mass="15214" checksum="83DAEA0C29A3AFA5" modified="2022-05-25" version="1">MFCELMHQLSKTRKHQVYSYVDDKRKTVLVDSKTDKFLFGEDLGKRIKSATMVKKVGLSLKTTPDKADSSKSRNFLNWKSSTVTQSGCQQSSFNQKTLNKFPRSNRAPVQQNSTRSSTRSQSRLNQFNNPSTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2GZE2</accession>
    <name>A0A8J2GZE2_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phosphatidylinositol-3-phosphatase SAC1</fullName>
            <ecNumber evidence="1">3.1.3.64</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Phosphatidylinositol-4-phosphate phosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Suppressor of actin mutations 1-like protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HICCMSTLAB_LOCUS403</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:55652"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57880"/>
            <dbReference type="ChEBI" id="CHEBI:58178"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="3">
            <dbReference type="Rhea" id="RHEA:55653"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:12316"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57880"/>
            <dbReference type="ChEBI" id="CHEBI:58088"/>
            <dbReference type="EC" id="3.1.3.64"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="2">
            <dbReference type="Rhea" id="RHEA:12317"/>
        </physiologicalReaction>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.64" evidence="1"/>
    <dbReference type="EMBL" id="CAJNRD030001114">
        <property type="protein sequence ID" value="CAG5073460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2GZE2"/>
    <dbReference type="OrthoDB" id="405996at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004438">
        <property type="term" value="F:phosphatidylinositol-3-phosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043812">
        <property type="term" value="F:phosphatidylinositol-4-phosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002013">
        <property type="entry name" value="SAC_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45662">
        <property type="entry name" value="PHOSPHATIDYLINOSITIDE PHOSPHATASE SAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45662:SF2">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-3-PHOSPHATASE SAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02383">
        <property type="entry name" value="Syja_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50275">
        <property type="entry name" value="SAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAC" evidence="7">
        <location>
            <begin position="124"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00036631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00036807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00040795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00041396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00041911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG5073460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="337" mass="39099" checksum="A066AEDF6483C644" modified="2022-05-25" version="1">MTTNTDVYDDLFLYTTNEKFYVEAVTAKVLLIVDRVNQHIFTQVGTANQISQTAIRRKIWGIVGTIKLLSCRYLIVITDAKRIGTIAGQQIFQMTATDVIPYSKSDLHLTDKQIENNTTYLEMIKSVLNTPYFYFSYTYDLSHTMQRLHNTTPEFLQVYKLMPLHDRADSRFIWNAYLLQDLSSRSEHSNVHRAGTRLFSRGIDTNGNVSNYVETEQLIEVNGDRSSFVQSRGSIPLFWQQEPNLKYKPKPQLCSHENHQIAASRHLDAQIFHYGKQILVNLIDHRGAENVLEKEYRAVVSRIGNQNVRYEAFDFHAECRHMRWNCEVVPLPALPVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2GZM3</accession>
    <name>A0A8J2GZM3_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Similar to Luciferin 4-monooxygenase (Photuris pensylvanica)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HICCMSTLAB_LOCUS797</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001114">
        <property type="protein sequence ID" value="CAG5074025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2GZM3"/>
    <dbReference type="OrthoDB" id="10253869at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016405">
        <property type="term" value="F:CoA-ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096:SF149">
        <property type="entry name" value="AMP-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="5">
        <location>
            <begin position="241"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="6">
        <location>
            <begin position="398"/>
            <end position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAG5074025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="488" mass="54460" checksum="660679CFA6B624CA" modified="2022-05-25" version="1">MAANELKLKIPKPTYENKIWKGVEINLPEGYFQIGERLYNQLKNNPDFVGQIDSVTGEKRLFSNISERSIKCALWLKKQGVKPGSVVSFCSKNHFDRCIPLFATYYLGAIFNPWWDCCLTNAAQDADPSVKIIIFGKKAGLKSFEDILQENINELDKFQCTKISKADDPALIMCTSGTTGFPKGVLHSYGSVAHTISLFPINTTTNTFLSFSTLCWISELTLVLRSVTRVPMGTHIANRFSKTPDISKYDVTSVAEVVLFGASTTKEVILFLDNFFENADIYNAYGSTESLIVTIGKVDSSKSNSCGKICPNAQLKVVDPQSKATLGFNQTGELYCRSKSLMTGYWNNSAATEEVIDSEGWYHSGDLAYYDEDGNFFIVERIKELIKYKLRHVSPAVIENVILNLPGVAEVAVIAKPDDNDVELPMAFVKKNPLVQVTEDDIHQIVNDNLHDMMKLRGGIYFLEEMPHTVTGKISRKELRAMVKTLAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H0H4</accession>
    <name>A0A8J2H0H4_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Insulin-degrading enzyme</fullName>
            <ecNumber evidence="8">3.4.24.56</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Insulin protease</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Insulysin</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">HICCMSTLAB_LOCUS2112</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>Degradation of insulin, glucagon and other polypeptides. No action on proteins.</text>
            <dbReference type="EC" id="3.4.24.56"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 12">Belongs to the peptidase M16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.56" evidence="8"/>
    <dbReference type="EMBL" id="CAJNRD030001116">
        <property type="protein sequence ID" value="CAG5076131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H0H4"/>
    <dbReference type="OrthoDB" id="952271at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043171">
        <property type="term" value="P:peptide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000003">
        <property type="entry name" value="Insulin-degrading enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000005">
        <property type="entry name" value="nardilysin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000004">
        <property type="entry name" value="Putative insulin-degrading enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.830.10">
        <property type="entry name" value="Metalloenzyme, LuxS/M16 peptidase-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011765">
        <property type="entry name" value="Pept_M16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001431">
        <property type="entry name" value="Pept_M16_Zn_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050626">
        <property type="entry name" value="Peptidase_M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032632">
        <property type="entry name" value="Peptidase_M16_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054734">
        <property type="entry name" value="PqqF-like_C_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43690:SF18">
        <property type="entry name" value="INSULIN-DEGRADING ENZYME-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43690">
        <property type="entry name" value="NARDILYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00675">
        <property type="entry name" value="Peptidase_M16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16187">
        <property type="entry name" value="Peptidase_M16_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22456">
        <property type="entry name" value="PqqF-like_C_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="LuxS/MPP-like metallohydrolase"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00143">
        <property type="entry name" value="INSULINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M16 N-terminal" evidence="14">
        <location>
            <begin position="77"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M16 C-terminal" evidence="15">
        <location>
            <begin position="241"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M16 middle/third" evidence="16">
        <location>
            <begin position="426"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="domain" description="Coenzyme PQQ synthesis protein F-like C-terminal lobe" evidence="17">
        <location>
            <begin position="823"/>
            <end position="921"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="205"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00052248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00066874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00070422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00074992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00080349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF05193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF16187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF22456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="CAG5076131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="1033" mass="118638" checksum="20FBA20A45D29EA9" modified="2022-05-25" version="1">MFIARNINNNNKSRLIVVFQQLSSTMNRNLSGSTGEEAPTTSLEMNKDIIKKRFEKIKKSPNDSQLYRGLILNNNMKVLLISDPTTDKSAVSLDVNVGYLNDPAELPGLAHFCEHMLFLGTEKYPDKNSYNSYLSQHGGSSNAMTLPDYTQYHFDVSPEYLEGAVDRFAQFFIAPLFTESATELEVQAVHSEHEKNIANDTWRQDQLEKSSADPNHPYSKFGTGHRGTLDSGPKQKGINVREALLEFHKTWYSANIMALSILGKESLDQLEKMIVDKFSPVENKEVEAPTWPEHPFNDDHFGKKWVIVPIKDIRALKMTFPLPDLSQHFRSGPAHYVSHLLGHEADGSLLSALKKAGWCNALVAGEKRAARGGCNFFSIYVDLTEEGINHVDDIVKLTFQYINMLRINGPLEWIFDECKQIANVDFNFKEKLLPRTTVNVTVRALQKYPFEEVLTGPYLPTEWRPDLINTVVDCLVPEKIRIHVVGKVYQNIADQLEFWYGTKYAIQVIPKEIIESWRNSGLSDELKIPNANEFIPESFEIKCNSNREEINKFPKIILDTRLMRVWFKQDDEFKIPKVNLTFDFVSPYAYLDPCNFNLTNLYIQLFKDSLNEYAYNASLAQLSWEFSASKNGMTLMVGGYNDKHRVLLSKIIDRMVNFKVDNQRFEIIKEIYIRNLKNFEADQPYQHAVYYLAVLLTEQGWTKDELLEATEFLTLDRLEEFIPKLLTKVHIQCLIHGNLTESEALETIKMVENQLTKDPQDSEKSKTIVPLVPKQYILNREISLDNGSHYLYEIENKLHKSSCTEIYYQVGLQSTESNIHLELLGQIISEPFFDVLRTQEQLGYIVFSGIRRGNGVQGLRVIIQGDRHPQYLEERIEAFIHSVQDRIVNMSEDEFNRHKTSLANQRLEKPKKMTTLSAIFWSEITNQQYNFDRANIEVAYLRTITKSQILDFYNETIKQSPQRRKLSLHVVSTAPGGAGFTEKSSEESSTAQTDATTLPIKITDILAFKSSQSLFPIIKPFINIPRKDQKSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H2W1</accession>
    <name>A0A8J2H2W1_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Similar to Etv5: ETS translocation variant 5 (Mus musculus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HICCMSTLAB_LOCUS1721</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the ETS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001116">
        <property type="protein sequence ID" value="CAG5075567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H2W1"/>
    <dbReference type="OrthoDB" id="10067219at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000121">
        <property type="entry name" value="ETS translocation variant 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000418">
        <property type="entry name" value="Ets_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046328">
        <property type="entry name" value="ETS_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11849">
        <property type="entry name" value="ETS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11849:SF282">
        <property type="entry name" value="ETV5-RELATED PROTEIN ETS96B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00178">
        <property type="entry name" value="Ets"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00454">
        <property type="entry name" value="ETSDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00413">
        <property type="entry name" value="ETS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00345">
        <property type="entry name" value="ETS_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00346">
        <property type="entry name" value="ETS_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50061">
        <property type="entry name" value="ETS_DOMAIN_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ETS" evidence="7">
        <location>
            <begin position="140"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="12"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="304"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="25"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="40"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="310"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG5075567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="429" mass="48837" checksum="D94298757099B72D" modified="2022-05-25" version="1" fragment="single">ARNLIYQRRQQYTNNSLITRDPRDSPTSSKPTSTSSVTSQWLTPTQSNQSTIEQNFVSRSDNWPSSANANVSTRNRLSPTWTKLGIQSDIKTPSWERQTVYQKKISATWNSEYIKKSSSSGLLSWPDVSVGYQQQRRGSLQLWQFLVTLLDDPANSPCITWTGRGMEFKLIEPEEVARRWGIQKNRPAMNYDKLSRSLRYYYEKGIMQKVAGERYVYKFVCDPEALFNMAYGVGVSNPTVESSGTVARTSINKIETTANISDSTKHPSEGYGDAVLAMYSNTTMYGQSSLHHLHQYLGTNDSFKTPPARLHTHHHTHQYNSHLHHHYHHHHHSSSPYSDSFLNYSRLSQELPYDIRTQEHINSTCNDYFHDEHSNKVKESSVAFDSSQIRSQLSSSISSSENSNILETTSTSSKIEQAYSCLSVDSCVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H331</accession>
    <name>A0A8J2H331_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS422</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001114">
        <property type="protein sequence ID" value="CAG5073479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H331"/>
    <dbReference type="OrthoDB" id="7701525at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005312">
        <property type="entry name" value="DUF1759"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331">
        <property type="entry name" value="PHD-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331:SF5">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03564">
        <property type="entry name" value="DUF1759"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="274"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="274"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5073479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="329" mass="37380" checksum="70086AAACE5E3C0C" modified="2022-05-25" version="1">MTAVEAAQNQSYRLWHDITNLNSLIFEMYPEVLQHEYHTGNRYTTAHASYTTLETRIATPKDAIQEEIDARDAEQAQNTLAMHSTAYMGGSSGTGLPKIKLHTFSGDFKRWGSFSQLFSDIVIDNALLKNSQKMHYLKTFTEKEAHQLIGNMPSTDDSFEPAWNLLKNRYSNPRRVVASHLEDLLVGESVPARSAAKLDALLLSNQKALDSIKAQGVPVNNWDLMIIHLTLRRLPPAVREDWETSLGLTDTMPTYTQLHEFLKSKVRAWENLEPASEPKKQPENHKSGGSRSDKQPRTKSSYTAAQYKGKPRRNCPLCPEEHYIHKNFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H5F0</accession>
    <name>A0A8J2H5F0_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Similar to 5-hydroxytryptamine receptor (Bombyx mori)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">HICCMSTLAB_LOCUS588</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001114">
        <property type="protein sequence ID" value="CAG5073755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H5F0"/>
    <dbReference type="OrthoDB" id="5956310at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24248">
        <property type="entry name" value="ADRENERGIC RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24248:SF125">
        <property type="entry name" value="DOPAMINE D2-LIKE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="7 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 14" id="KW-0675">Receptor</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="108"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="137"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="13">
        <location>
            <begin position="89"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="55"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CAG5073755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="192" mass="21083" checksum="DB7BAF65896FF8F2" modified="2022-05-25" version="1">MEFKTMSMDTGHAVGNALAQAQVSGGIAAAVVTVIGRPLPTISETTTTTTAFTTVSSNNTSPEKTSYHNGLEPEPSTMDGLPAKPAVVIRKKKKAAESKRERKAAKTLSIITGAFIICWAPFFVIAILLPVCQSCNINVYLIAFFQWLGYFNSTLNPAIYTVFSPEFRSAFKKLLCRRRRAVGRRMGVRHYM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H5G3</accession>
    <name>A0A8J2H5G3_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS694</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001114">
        <property type="protein sequence ID" value="CAG5073922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H5G3"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035211350" description="Secreted protein" evidence="1">
        <location>
            <begin position="27"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5073922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="120" mass="14023" checksum="974F590B1EE98414" modified="2022-05-25" version="1">MLVLLLFPAFSLLHLLIAVSCNQVLAWHTNYSQSPVCFDRHEHSYRTSRSFRGIRRVLSATIFWEWKRDTEKKINLETKKKDTFGAKIKEITYSFIDSDCCGYFDPNFVLFSGISRYSLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H5V3</accession>
    <name>A0A8J2H5V3_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Similar to cmpk1: UMP-CMP kinase (Xenopus laevis)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HICCMSTLAB_LOCUS2297</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the adenylate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001117">
        <property type="protein sequence ID" value="CAG5076844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H5V3"/>
    <dbReference type="OrthoDB" id="442176at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019205">
        <property type="term" value="F:nucleobase-containing compound kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01428">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00235">
        <property type="entry name" value="Adenylate_kinase_Adk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000850">
        <property type="entry name" value="Adenylat/UMP-CMP_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23359">
        <property type="entry name" value="NUCLEOTIDE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00406">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00094">
        <property type="entry name" value="ADENYLTKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 5" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAG5076844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="176" mass="19647" checksum="594E85F22419035F" modified="2022-05-25" version="1">MIINKLLGLRRIAMSAIQKPEVIFVLGGPGAGKGTTCKDIVKKTGYVHLSAGDLLREEQNKPGSEFGELIKGHIVAGTIVPNMTDKAIVKAVLYLECSQEVCTRRCINRGLKGSGRSDDNAESLVKRHQTFIKDTMPIIKYYEERGLLYKFNSMKPPKVVMKEVYEKFKEIGWATD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H659</accession>
    <name>A0A8J2H659_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Metalloendopeptidase</fullName>
            <ecNumber evidence="10">3.4.24.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HICCMSTLAB_LOCUS2633</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="10">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="10"/>
    <dbReference type="EMBL" id="CAJNRD030001117">
        <property type="protein sequence ID" value="CAG5078054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H659"/>
    <dbReference type="OrthoDB" id="291007at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00041">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.290:FF:000013">
        <property type="entry name" value="Membrane frizzled-related protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.290">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000859">
        <property type="entry name" value="CUB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001506">
        <property type="entry name" value="Peptidase_M12A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035914">
        <property type="entry name" value="Sperma_CUB_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127">
        <property type="entry name" value="DISCOIDIN, CUB, EGF, LAMININ , AND ZINC METALLOPROTEASE DOMAIN CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127:SF850">
        <property type="entry name" value="METALLOENDOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01400">
        <property type="entry name" value="Astacin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00431">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00480">
        <property type="entry name" value="ASTACIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00042">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49854">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51864">
        <property type="entry name" value="ASTACIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01180">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="4 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 10" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2 10" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M12A" evidence="12">
        <location>
            <begin position="1"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="11">
        <location>
            <begin position="151"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="11">
        <location>
            <begin position="267"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="41"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="151"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAG5078054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="383" mass="44175" checksum="7D18A36CFBC188BA" modified="2022-05-25" version="1">MCTSQNQMLRCYTNGVGRSHAGRNHVYLGENCLTKRIMLPELGHIIGLHHEHKRSDRDKYVRVNIDNINNQKGVMNDFEKLSSEDAVTFNQTYDYNSIMHYRTNAFARDRSKQTITPLKAEDIQIEKIGRQERLSEIDIRGVKMLYNCSVCGQLLENDTGTLETTIYVNTSTTTAKHCEWSIVASRGERIVLEITTLSILDSKDCTIDYLNIRDEYKTGYNSLGRFCRKKSTTQTVGSSDSRILVTYHANNANEEYFDFKAKYHTYFEGDIEINNKDQEYFLESPGFPNEYPPNKYRVWYLVAPFNSRLILKFTYFDLETSDNCNNDYVEIRNGDAYYSPLIGKYCNNTSPEVIWSKGYALYVNFVSNSKVQGGGFSAIITLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H6F0</accession>
    <name>A0A8J2H6F0_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS2770</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001117">
        <property type="protein sequence ID" value="CAG5078528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H6F0"/>
    <dbReference type="OrthoDB" id="7692677at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31912">
        <property type="entry name" value="IP13529P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31912:SF34">
        <property type="entry name" value="NOTOCHORD-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5078528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1267" mass="146145" checksum="52AB6C5ECF62C765" modified="2022-05-25" version="1">MEKFLEDWQLLSLWPIFSEHELNDFETFDDYMTLSSQEEIKELIPKAGLKVKLLKKYQEQKQLQVLNVSQTQTTVASDIVLDIPASFPSTSGPVLTEEEAILLKLISTENDLAGSQHKVVLDTSEVDNSTPESVNEDPPLKKRKLSSIDYVDLQELLNDHPLGPSVLTEKNLEKLAQDFKKCFPNECIESYYIASESKKNSKTGKPIGAKGKLVNSYKNNCTWIREGLQWEEIGKAKAQKISVNAAIHTVTDVDDTELIDSKAWLVTNRDKENLLMHWELCYEQRRKEINSNKFKGITEIFEDWPVLKENIGCELIEIDFEKLFGTINFAAQWENYFKKTVKFFQKKSKNLIIEELELLDQPNLSEDSIHILQAKILIFLLAPKSNKAIIKSAKNNGGFWRPDAKEAQADVFVHVKIAGDIEKVVRKKSRKYGKLGLHMQPFIIIVGQDLQSITKFYVRVDSVQYEVESFLKCLEIIQKLSLIFKVSYSLASENFWYFVQGGICEITTKEDTKIPSVLDLINNLVEHLSTSHPLERSYNCFNKDCFRKFLNIVDLKSHIFKCPYLQHEKKNNNNDMIQTNMLTFLGKLYNNSSITNSVVQEIISNTLALTEEMKKFYLQKIMAITPPETHQPLISLFSQNNFDYLSTECKRMTYFKSLNVYIPPEKVIISEISDDKKVNGSTMRTTKTCYAQFASMTEGLKYFFELPNVLQEVLKYMNEEVTKTHYNNCYTSLFQGTIWQQVAKQYVGKIVIPYYIYYDEFGVGDPFTPAATLHKMGGLYYSIASLPPKYASTVDNVLLAQLTYYSDYKEFKNAKCFCRLISELKHLATKGIEIKFNNKVVPIYFVLFGVLGDNLAANSLLGFSQSFSSNYFCRFCRASKEDTKILCVENEQLIRNKNNYDEDVKSQSYGIKEECVFNSIPHFNNTLNLTCDILHDFYLSICRYDMAKIIKYLIDEEFITLEDLNDRLRYFDYTEVDHGNKISFISEKHISQGYIIITGAEMSSLVTYFGIIFGDCVPEKDPVWEFYLLLFDLINLVTADSFDEHDLSSLQALIQTHNELYIKLFQGNLTAKFHILTHYPRIIKAMGPVKNLSCSKFECFHQKFRKYAHVVNSRVNIGYTLANKAQLELSYRFLSKEGFKNYIEVGQTVDSNLDIPGSSLYEISWTKVNGKIFRPGYAIYIRQNINDDPVFGIICRIITNKDQCIYFIYQESSTIGLCNHIKGFLLTLPKANEKFQLMYYDTNSYRKPLKIHVTANGSNVITCRDFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H6F5</accession>
    <name>A0A8J2H6F5_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">EGF-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS2693</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001117">
        <property type="protein sequence ID" value="CAG5078266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H6F5"/>
    <dbReference type="OrthoDB" id="504708at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006149">
        <property type="entry name" value="EB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39069">
        <property type="entry name" value="ECDYSONE-INDUCIBLE GENE E1, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39069:SF8">
        <property type="entry name" value="FI17111P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01683">
        <property type="entry name" value="EB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EGF-like" evidence="1">
        <location>
            <begin position="9"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="1">
        <location>
            <begin position="100"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="1">
        <location>
            <begin position="159"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="1">
        <location>
            <begin position="241"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="1">
        <location>
            <begin position="366"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="1">
        <location>
            <begin position="490"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="1">
        <location>
            <begin position="551"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="1">
        <location>
            <begin position="593"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="1">
        <location>
            <begin position="668"/>
            <end position="710"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5078266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="714" mass="80768" checksum="702E0FAF80F90C55" modified="2022-05-25" version="1">MCGKFLDSVCQQDDDCGPENSICVDNHCKCEPNFFREGNSQCNSRMCLIDAAQLKMPCSTYTDCNSLIKHSLCSENNKCECFPTYFRINETACVPYHESYCSDSDPCKLENSVCINNLCRCASHYSYIGLKCEPTFLDKPFKQHINGDTPSCKSLLKGICYKNSDCFVENSICINNKCQCKIDYAPDFNNRCVSKLKTTCNVDHECKTLYFQQCSIDMKNTFNSSYTSMHNFKCKLQIGDKCRLDEQCTPEHSRCIDNWCQCKPKFVPSGVGNKCVSVYSNRKCTTHDDCAHIQNGMCSDDNVCICETNHEQTDENTCLPFLGQYCDKQTKCTTDNAVCSYNTCACDTLFTQQSINRCLPTYLKQPCKLQDDCRQIKYAECSKDNKCVCRSNYIELNAVTCAPFLGGYCESDEECFVNQTKCIDNKCAHVPNARPRTIEQHPPSSTRKCQDDRDCLFVKNTICLSNGGCGCKLNHISVNQTLCLPLLNEDCSNSPCIVDNSYCIKDQCQCADHFVQHLNNKCLPSKYTYFHMELEILVVTEIFPLAWLNEPCKTDADCKKIKNEICSKKKTCVCKTSFNQFSLTRCTSLTEEFCTSNKDCPVENSACTNNFCECKPGFEKLYNNQCIPQMAISSCSDDLECGEPWHGECSNEKKCSCKENNVAINISTCYPLLKGLCWRDEQCVTKNSICLDYHCLCEAGYIPVANNLCVRANL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H6G8</accession>
    <name>A0A8J2H6G8_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Similar to boka: Bcl-2-related ovarian killer protein homolog A (Danio rerio)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HICCMSTLAB_LOCUS2800</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Bcl-2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001117">
        <property type="protein sequence ID" value="CAG5078650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H6G8"/>
    <dbReference type="OrthoDB" id="6021377at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051400">
        <property type="term" value="F:BH domain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097192">
        <property type="term" value="P:extrinsic apoptotic signaling pathway in absence of ligand"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008630">
        <property type="term" value="P:intrinsic apoptotic signaling pathway in response to DNA damage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042981">
        <property type="term" value="P:regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001836">
        <property type="term" value="P:release of cytochrome c from mitochondria"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06845">
        <property type="entry name" value="Bcl-2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.437.10">
        <property type="entry name" value="Blc2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036834">
        <property type="entry name" value="Bcl-2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046371">
        <property type="entry name" value="Bcl-2_BH1-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026298">
        <property type="entry name" value="Bcl-2_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002475">
        <property type="entry name" value="Bcl2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11256">
        <property type="entry name" value="BCL-2 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11256:SF48">
        <property type="entry name" value="BCL-2-RELATED OVARIAN KILLER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00452">
        <property type="entry name" value="Bcl-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01862">
        <property type="entry name" value="BCL2FAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00337">
        <property type="entry name" value="BCL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56854">
        <property type="entry name" value="Bcl-2 inhibitors of programmed cell death"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50062">
        <property type="entry name" value="BCL2_FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="256"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="domain" description="Bcl-2 Bcl-2 homology region 1-3" evidence="8">
        <location>
            <begin position="130"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAG5078650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="278" mass="30263" checksum="ACD35CA1F5840677" modified="2022-05-25" version="1">MVSRVVNKLEDKLLLSVPPVTVNVRRSSLSLLNLPDGLAFQGVAGSARRRLSNVSDVVSKKISDTIGWRSLSTNVELTVMQGSVLCGQYIKNRLKRSGIFQKKLGLKRMRSGAIMSSEGLLVVSEVSPVLTSLGAELEKLHPKLYTNIARQIGAGSFSNEQTAMEAIADVSRELLRVGGEMTWGKIISLYSVAGGIAVDCVRQGKPEFIGAIQRAMTIVLEEDLASWIQANGGWIGLSNKCRTSIDSDTWQERDTLIVLVSTTLIMGLALLIRIFIFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H766</accession>
    <name>A0A8J2H766_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS3299</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5081493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H766"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="193"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5081493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="297" mass="34204" checksum="F94E192EC24EBBD5" modified="2022-05-25" version="1">MSYLKRNCTHLEGQYIFPEEWKKYRVTKPPTRYVEDNANSLELKPLMVPYGILDELFKWHDMVNSVYDKYCEQERSGCEMTEVEATESADSKQHTQSADSGSEVIATPTLPMITRHNVPYQKWPSHLPDQFLLLIRSLLYQRFDRLKRCRQSDFSNDTHKSTELSPAKITKVQPIDLSADKVLQKKFVSNLPTKTSSVKKETEQPQPAENKFKTTNITTPPPSAEGTSTSTLRPVNHLPSTSQLNQQGTSYQQTNHNAKKSITLYNLYRSEFDEIDSSLQDIINKTQECRSKMAKLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H7H8</accession>
    <name>A0A8J2H7H8_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS3053</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001117">
        <property type="protein sequence ID" value="CAG5079603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H7H8"/>
    <dbReference type="OrthoDB" id="7701485at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="330"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="392"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="464"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="338"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="396"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="417"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="464"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="480"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="547"/>
            <end position="563"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5079603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="563" mass="63585" checksum="F106176FD7B67142" modified="2022-05-25" version="1">MYEDIQELASGKLRADETLKRGILLANHTECKSQGGAPFIIQIASVAGEQYLSVLNDLSHPIVLGMDFALQFGVIIDSKTRTWRFSGSPEFYPFELVSCKERSSDCAEITSEQDQDSQEFLRGENPENFPDWRIVDDRLNYHRPDPLKSIVRDDTAWKLVLKDSESELGDLDLDQDEWKQRVSRLDELRHKIENKMQRESERQARYYNQDRSIPEVQVGDKVFYPNRKLSSKAQGYSASLGNKYLGPATISRVVSPLVVELMERQGRRSRGVGRAEMMRRCASRREVPRFGRAYGVARRATRAQSGSFQIGILSEPPAGRVRAPSRSAFDRLGPVISPSRSSAPGMTEQSGGRLPFRDLAITLHVDSEQAAGLPDPRPSVQLACPGLIATEAPEINKNSPPATLESTVEPVAEAPKRRTKEQKRRQYRKQKLRELLDRPDASPERLKNLCRHLTGSSTAARRYLSGNQPSHFHPENSTTEELRPEKRQLEVLESVPEIADQQEEARGLPILPEAEYSPPRPRVEGLAEANVQGVRPEVSGNQVQQVQKKKRKNRRKNKERGPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H7J7</accession>
    <name>A0A8J2H7J7_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Defensin 2_Cc</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HICCMSTLAB_LOCUS3319</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5081559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H7J7"/>
    <dbReference type="OrthoDB" id="8109893at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006952">
        <property type="term" value="P:defense response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051707">
        <property type="term" value="P:response to other organism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.10">
        <property type="entry name" value="Knottin, scorpion toxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001542">
        <property type="entry name" value="Defensin_invertebrate/fungal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036574">
        <property type="entry name" value="Scorpion_toxin-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57095">
        <property type="entry name" value="Scorpion toxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51378">
        <property type="entry name" value="INVERT_DEFENSINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035214189" evidence="2">
        <location>
            <begin position="30"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="domain" description="Invertebrate defensins family profile" evidence="3">
        <location>
            <begin position="33"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG5081559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="73" mass="7945" checksum="575069A2C5CE1568" modified="2022-05-25" version="1">MAKSYSSMLLLVCLAFLVIVSSPKNEVQADKSIGSCVWGAVNYVSNCLEECKRRGHKGGHCGSFANNICWCET</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H7N5</accession>
    <name>A0A8J2H7N5_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to Wdr47: WD repeat-containing protein 47 (Mus musculus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS3279</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5081411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H7N5"/>
    <dbReference type="OrthoDB" id="187712at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040067">
        <property type="entry name" value="WDR47"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19863">
        <property type="entry name" value="NEMITIN (NEURONAL ENRICHED MAP INTERACTING PROTEIN) HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19863:SF5">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="306"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="400"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="490"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="536"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="120"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="164"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="203"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="124"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="175"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5081411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="572" mass="63356" checksum="147D677C464ED72D" modified="2022-05-25" version="1">MGDIRILDPRMDPRFGGDFKPRPWPAMYRNYPARGPSFCYRPVPIETLTQWIAPHLPHDYNYNVIPPGIRPKKGREMGTRDYYYLGPMYQNALPPPNGPSGPGLQMAPMTMAPPRMMLMEGKSRNGTKTSSSNGAGRSSVPCTCSVGRTRSLEDVRSEVVEWEEYSDENGNRVKGNPKAHGKHTRRSMENLLDVDNSCSTTFNRKSCGGKSRQEGRDCRRRGSYMPEPRSELDSTNGSSHNGRPRFVPVTALEDVQAVRCAEFHPHGKLYAVGSNSKTLRICAYPKLHDVREDHQTYQPTVLFKRTKHHKGSIYCLAWTPDGQLMATGSNDKTVKLMRFNADTSNLEGQEVELTMHDGTVRDLCFLEDTSNKSSLLISGGAGDCKIYVTDCTTGTPFQALSGHSGHVLTLYNWGGAMFVSGSQDKTVRFWDLRTRGCVNMVTPATVPGSRVGSPVAAVCVDPSGRLLVSGHEDSSCVLFDIRGGRTVQCFKPHAADIRSIRFSPSAYYLLTGGYDNKLVLTDLQRDLTLPLPSVVVAQHQDKVISGRWHPTEFSFLSTSADKTATLWALPPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H7X5</accession>
    <name>A0A8J2H7X5_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Similar to Nup358: E3 SUMO-protein ligase RanBP2 (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HICCMSTLAB_LOCUS3784</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5083262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2357150at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006913">
        <property type="term" value="P:nucleocytoplasmic transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00835">
        <property type="entry name" value="RanBD_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13179">
        <property type="entry name" value="RanBD_RanBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000018">
        <property type="entry name" value="E3 SUMO-protein ligase RanBP2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1060.10">
        <property type="entry name" value="Zinc finger, RanBP2-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000156">
        <property type="entry name" value="Ran_bind_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045255">
        <property type="entry name" value="RanBP1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045256">
        <property type="entry name" value="RanBP1_RanBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000697">
        <property type="entry name" value="WH1/EVH1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001876">
        <property type="entry name" value="Znf_RanBP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036443">
        <property type="entry name" value="Znf_RanBP2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23138:SF87">
        <property type="entry name" value="E3 SUMO-PROTEIN LIGASE RANBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23138">
        <property type="entry name" value="RAN BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00638">
        <property type="entry name" value="Ran_BP1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00641">
        <property type="entry name" value="Zn_ribbon_RanBP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00160">
        <property type="entry name" value="RanBD"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00547">
        <property type="entry name" value="ZnF_RBZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90209">
        <property type="entry name" value="Ran binding protein zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50196">
        <property type="entry name" value="RANBD1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50229">
        <property type="entry name" value="WH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01358">
        <property type="entry name" value="ZF_RANBP2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50199">
        <property type="entry name" value="ZF_RANBP2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="12" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="repeat" description="TPR" evidence="6">
        <location>
            <begin position="50"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="RanBD1" evidence="9">
        <location>
            <begin position="1179"/>
            <end position="1312"/>
        </location>
    </feature>
    <feature type="domain" description="RanBD1" evidence="9">
        <location>
            <begin position="1406"/>
            <end position="1551"/>
        </location>
    </feature>
    <feature type="domain" description="WH1" evidence="11">
        <location>
            <begin position="1431"/>
            <end position="1549"/>
        </location>
    </feature>
    <feature type="domain" description="RanBP2-type" evidence="10">
        <location>
            <begin position="1589"/>
            <end position="1618"/>
        </location>
    </feature>
    <feature type="domain" description="RanBP2-type" evidence="10">
        <location>
            <begin position="1646"/>
            <end position="1675"/>
        </location>
    </feature>
    <feature type="domain" description="RanBD1" evidence="9">
        <location>
            <begin position="1827"/>
            <end position="1961"/>
        </location>
    </feature>
    <feature type="domain" description="RanBD1" evidence="9">
        <location>
            <begin position="2351"/>
            <end position="2487"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="788"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="894"/>
            <end position="913"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1306"/>
            <end position="1337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1353"/>
            <end position="1388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1405"/>
            <end position="1426"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1744"/>
            <end position="1764"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="2207"/>
            <end position="2230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="2317"/>
            <end position="2353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="2481"/>
            <end position="2516"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="866"/>
            <end position="893"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="788"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="806"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1353"/>
            <end position="1362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1415"/>
            <end position="1426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="2210"/>
            <end position="2230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="2329"/>
            <end position="2339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="2481"/>
            <end position="2494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="2495"/>
            <end position="2516"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAG5083262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="2623" mass="294042" checksum="9206DED966043B3D" modified="2022-05-25" version="1">MFRTKTSVDRHVQELFRKITDEKELYYQVGDFESARRYVSNYLELKVESAGAHKLLAQIYEALGQKESALAQYQLSLELDARQDDLILKVCELLIDVDISLDINRIKYWVDRAGEKFPHHQIVFQLKEKMLSSDRSGIDDDLEGLIISELSTRPSDVMLRVKLLKHYIAKNRIDDAYRHAIEAEANYIYRDNLQWYETLIDVLSIYRETNKLNQSFWINYLASWERFAALSCKEGDKAKTIPEATQIILNFDSTLHEVKQQTHQSSSFIDQMLHHMWGQLHYHLACLLLRKAKREQKNWIETARLSSPLLLSAFHTSPIDLTGSWAANLKGSSKTLASLWRKEGCYRCSQAAHVLQDYARDNPKKLMDKIEEFMNNSWRENIYRKIFNKTHEITNSYFVKNSGQNPPLRLLSSNELKQYDEESKEVYSDSLHHHVWLGIVNKPRLKSNEDLGPYPNEYSHVFPNLQLSVYNLSQASPDSLGVLDIDAFLNATILCSLKIVEEQQKNGLLSPERMPTLPADLTNSLCSSVQEKWWMYAYKIYRRSEIMGCDIGEIRQEVQRGLEVIRCIGSHGLHPSILVQLARIFQHRCKLLKDKDSNDLPFIQARCELYWSAAVPLLERLLNNQQIRMINTRIFDYQGKEMNNIELSNSLEEGRLLVACKYIRDRNYEQASDILTSLKCPEASFHQGEIYKKLADELIESLPKESITSSIRSQYNIMLTKARNCFYLTLDRLRSPGINPNHPLNAELGSRLASIEDELWRNDAKNDGDNGSDESYSSAHSITEQLANSTINHSTVTPRRNHRTPKLSSTPRQYPNTELDITRSRIQMEARPSPERLDAQIRQLLYTKDNILHSVMDQQKTLLESNKALTESNRQLQSIVEELRKEMAEFRLEAKKPKRTASANQYDDDPYNYEEDYSDVSYGVQSNINPPIQSTQPIQPIQPTLPIQPNVYQPRYPYSPYNQLNYYSGLPYSDPNIPQFFPPRYPLGLYPPDRNLVPKVPDMIQQGMIQPNLFNPLLNQFNDSTIVPVSPQIPVPQLSTDLPSNLLAPKDTASVKNVPVNKEPPVNVTITSSDIVPTSAPGVQPTLSIVIPPQHRKVTTLANSNANAQITTSTPHNYQILMPTGAKVPTSSHLSSIFSNSVFNNSTDKTNERNTSVVSTGSHNSSIEAVEVEHDPIPDFQPIIPLPAEITVTTGEEDEQTLFCARAKLFRFSEKEWKDRGVGNVKLLRNKEGKVRLLMRREQVLKICANHLLSPDMELKAMPNNDKAWTWAANDYADEEVRLEKLCIKFKLVEEAQLFKEEFNKAKQSVPVSPPKNKDLGKNNLSKEIANDSPADGNKSSIMVGGFSFSSTPVIQSTQAGDNNKLKQEESSKPSPFAGFSFSKSEPSVPSGFSFNKNISEADISSTKPALRKPQTPNSVPATSSKITGVINDDNEAVLFNKNVSLMRSSGESGQWKDRGTGSLMLLLNEKSHKLRILMRKSDTQKLCINQTLTNNFVVMNLSGASNVICWASTESNKSGKHETYAVSFKDAAEAEEFSDKIHRLVKLMNNANEIPGECISKTGKIVEIIEGASGKGVSKSLAEIFKPAVGSWECTSCYTRNNAGVGQCVACSAPSEAVPAIQKPVSSPIVNSNSNQSFGGLFKPQPDTWECKMCYIRNSKSDSYCVACDSPVDPSMPEKPKPNDALSSAPGQTFTFGIPKGTTATAGQSASLFTDMLKNQKESSTTPTGFSFGFNQPSKEGLGSFTFKAPGADTPSDSKPLDFSRFGQKSEKDFGFGSKKLEPPANTFAFGSPGKSFDFQFSKSPVKSPGAGDVSEDEVAESEDVYFTPVIPLPDKVDVKTGEEDEEILYCHRAKLFRYDAKTKEWKERGLGDLKILKNDKSNKTRFVMRREQTLKLCLNHFVTEDLEICKKDDKTWMWHAADYSDGEIEYAQFACRFKTPEIAGEFKEAADLAIANLISDSVKEFESSVQKSATNDVQVVFERKVTEEEKNAALKLQLPENFYAYKQKEDCQGCRGCKDEIPLLESEKTLLEADKSAATPLNIKLAPPKLSPSPLKAPTSAPATTSMNFGGTFSFGTSAPSFGATPIFGGNSNNDKDKKTSFSFGSFSESSAEKSPNLFGGKTICSPSTVNFGKSQAFNKTFGETQTPGWTFESSGSNNSIFGGASKPEANPSFSSFGTNSVGSKPEPIFGSIANDSSPVSFGSLAKSVTSTPPVQPTQTPTTTTTSSVFGFSSTPSTIFGGSIFGGKVFESANMTFGSANTDTKVAEAPAAQKIEASNAFLNTDNIATFSSLASKADQPIGFKTDPNFSFAGAGQSLFGAKSPPGKVEKDLKKDDKEENEEGQEYDPHYEPIIPLPDAIEVWTGEEEEEKLFSQRAKLYRYETETKEWKERGVGDMKLLYHSEKGTYRLLLRREQIHKIVCNFSISPELEFQPLKTSDRSLMWVGMNFIEGELVLEQLAVRFKNPQIAKEFKEAVESAQKNLRERPPRNNEDGNEYQEYQVEDDEEDNEDDDEHSMMFERDARLFYLDGGDWHPMADGMVKMFYDSDLYGARIIFETGSGELICNCVITIETEMQVDKNECIWTAIDDAFEPSVQRTLKAQFSNEDSAEEMFMNFQDGQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H9A1</accession>
    <name>A0A8J2H9A1_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Similar to Sstr4: Somatostatin receptor type 4 (Rattus norvegicus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">HICCMSTLAB_LOCUS4456</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5087233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H9A1"/>
    <dbReference type="OrthoDB" id="6076970at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042277">
        <property type="term" value="F:peptide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004994">
        <property type="term" value="F:somatostatin receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15094">
        <property type="entry name" value="7tmA_AstC_insect"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000231">
        <property type="entry name" value="Allatostatin C receptor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000586">
        <property type="entry name" value="Somatstn_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24229:SF40">
        <property type="entry name" value="ALLATOSTATIN C RECEPTOR 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24229">
        <property type="entry name" value="NEUROPEPTIDES RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00246">
        <property type="entry name" value="SOMATOSTATNR"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6 12" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 12 15" id="KW-0675">Receptor</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 12" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 12 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="35"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="68"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="104"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="144"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="211"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="256"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="297"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="14">
        <location>
            <begin position="47"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CAG5087233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="437" mass="49151" checksum="29BEE7D302DBAF0B" modified="2022-05-25" version="1">MNSTEFLQETLNTTNETLNFNCGTDLRIVAVVHQVIYTIVCVVGLLGNTLVIYVVLRFSKMQTVTNMYIVNLAIADECFLIGIPFLVTTLSLRYWPFGEIMCKAYMTTTSINQFTSSIFLFIMSADRYIAVCHPISATKMRTPFISKVVSMTAWFTSALFMIPVVLYANVNEFDNGISCNIYWPDNNIENKTHGNQTGLDEHQMHGGQTTFTLYTFFLTFAVPLTFILVFYFLVIKKLRTVGPKNRSKEKKRSHKKVTKLVLTVITVYVLCWLPYWITQVALIYEPPKQCQSSISITAFLLAGFLSYSNSAMNPILYAFLSDNFKKSFLKACTCAAGKDVNATLHNENSVFPKKNKSDHDRFKSSKAIASANSKAKLEEEDDERGLLISKTSTTTITMTSRTNITIISDSKEQKGLKGSGQKDNLRNGAQLTLLTQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HAM4</accession>
    <name>A0A8J2HAM4_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">chymotrypsin</fullName>
            <ecNumber evidence="8">3.4.21.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HICCMSTLAB_LOCUS5269</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Extracellular space</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase S1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.1" evidence="8"/>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5089522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HAM4"/>
    <dbReference type="OrthoDB" id="60866at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000068">
        <property type="entry name" value="transmembrane protease serine 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000047">
        <property type="entry name" value="Trypsin eta"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050430">
        <property type="entry name" value="Peptidase_S1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033116">
        <property type="entry name" value="TRYPSIN_SER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24276:SF96">
        <property type="entry name" value="PEPTIDASE S1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24276">
        <property type="entry name" value="POLYSERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00135">
        <property type="entry name" value="TRYPSIN_SER"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 9 12" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 9" id="KW-0720">Serine protease</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <keyword evidence="12" id="KW-0812">Transmembrane</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035188179" description="chymotrypsin" evidence="10">
        <location>
            <begin position="20"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="11">
        <location>
            <begin position="26"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="11">
        <location>
            <begin position="247"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="11">
        <location>
            <begin position="437"/>
            <end position="646"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00044036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAG5089522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="660" mass="71866" checksum="028F89A0A098B204" modified="2022-05-25" version="1">MQPIFFGILAIIALASTNAREIPSRVVGGEDAAEGAHPWQVSLRKYNSHFCGGVIVNERWILTAAHCIVYLPKSFITIVAGTNSLSNSGNVYEVDEIFVHDFSPSTIINDIALIRTTSEIEFSDKIQPIKISEQNFYAHGDPAVLTGWGYTGVTPDRLKEINLRIYEQSECQKHWWSLPESQICTLTEAGEGACMGDSGGPLVADGVQIGIVSYGKPCAQGFPDVYTRVRENSHYCGAVVLNSRWVITAAHCVVLVNTTGVTAVVGTNTLSSGGKVYHPDLFIVHKDYKLAVINDIALIRVSKAMKFTRKVQPVLLPTTDSLTKSYPVTLSGWGRNSTNGAIPENLQEIDLMVISQLKCRIYHPILLTRGHICTLTGDSGGPLTANGTLVGIVSFGSPCAKGVPDVYTRVYHYLNWINQTLAKANTNYDDDIPNFDGAYPYQASLRLSGFHFCGGVVINDRWVLTAAHCLYYMNIQNITVVVGTNSLKIGGDVYKTNYTTVHKNYTGDLTSDIALLRISGKFNLTKKVAPIPLAVKDETKKEYPAKLSGWGTTILGGAAPDKLQEINLTVISQVRCKSYHSIVTAGHICTLTTKGEGACHGDSGGPLTANGTLIGLVSFGRPCAVGYPDVYTRVFFYRDWIKKAIANADKPHDEDDIGNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HAN5</accession>
    <name>A0A8J2HAN5_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS5285</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5089555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HAN5"/>
    <dbReference type="OrthoDB" id="10017054at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000987">
        <property type="term" value="F:cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042594">
        <property type="term" value="P:response to starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14596">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14596:SF72">
        <property type="entry name" value="ZINC FINGER PROTEIN MSN2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="139"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="325"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="497"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="802"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1042"/>
            <end position="1124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="37"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="65"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="802"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1062"/>
            <end position="1079"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1105"/>
            <end position="1114"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5089555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="1145" mass="128454" checksum="2A6A010BB4DC4FD7" modified="2022-05-25" version="1" fragment="single">RWIRGQTKKKTVSDKSIDSEVADKISDGSLGTSDKLSSPGPENESSSPQLSAETMRSLNEEISRTLDLTGTITGTRTGTTTSGTATTTTTSTTTTQDETGDLSTHPKKDEVGKTVAGECRNILPVLVEHLRSALELTSASTKRSLADEPLAPDPLHNSQDSSATPLSSMDFNLFGDLLVSDIKTALVRLQDTLKRVDVDALTRYSATLESNDKLRLLQLISNLVSNLKLAKLSSDEEPVAVPPVPPVPAAPAVKKRFRGKDRHTIGVSSEELARARRWLEEKGTGVSLTSQRLSLAPQFTEPGKENAKVERESSEKMCDKHIKDKINQQQLQNRKDNDVPASESDIGDKLEEPVNFLNINNKVASNKFTAKKFKIKRANTIDIPNYLKLQAEKSQSSSPGLRRPIDIGDRLSWNQGSVLIPSFEPKTENDRKFLALINRNNNDNNINNNFYSNNVNTYNYSNGNSFNQPFKSFNYRQTSSIADKNWKSRFSNIKTAFDKPSPPASVDGSSRRSSISREESKHVIVGSLRLKPEPSAQKNNFGTKNGTFTHAATSPFQKINNKSINCNNSCNNDEKPTPSYYLPACASNGMLRAKLKMFDQQDTLGDPLPRVKSKANTKVNVKPEKIIKDTALNHCQNQIRNNGFRNSSYDNVKRHSGVYDSNGNITNHLININNNVINDDKKVQGQDIQKQSVAVQTNYPIELNDVENESLIRSCPRQLHNPKYQSVPRTFYENENPIYVPPKPVPTSRDIDFLVDANYSNRFIDDESENSFLDDENIANQDISDDRIVTRYTSAIATVENSPISPASVSPSGFQEGSGQPVLSDDVQRHNLLQQSLIRRLQYEPDSLIKPIQAPQVQLQPQPLIQFQPKPQPQFQPQPQNQFQPQTQFQPQIPVQFQPKLQNQLLNQNPRYSLINYTENTSPINEEPTQNGRESIEPLIESRNTLEKINIFEEKSTRRPEPLVIRPIYVPPKINIMSPSKTTPQSPKLTINPYVPSLPVKYSTPVDSSDEYLVNCATRPHRSIVLSKSESWHQLALSKNHLQVPPPAVPTHKPPRVSSKNFHGESADRNMKKMEEKVQRYFYKSEGQKRESSSSGSGKRRSFSPRKNNLTLARSHTMPHIYDDATDVDKAFDSLFEETTRDNRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HC41</accession>
    <name>A0A8J2HC41_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS6525</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5093014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HC41"/>
    <dbReference type="OrthoDB" id="9977011at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025271">
        <property type="entry name" value="CCDC28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13400">
        <property type="entry name" value="CHEMOKINE C-C MOTIF RECEPTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13400:SF4">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 28A-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13270">
        <property type="entry name" value="CCDC28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="137"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="53"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5093014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="179" mass="20498" checksum="40681A8CA021715A" modified="2022-05-25" version="1">MNEESRCGELQQLVREEEEEENEETTINASGEATPPTSPDKSQPSKNNYIPHASSTSSEQATSQGSMVSGKVNSHGNHHQLLQQSRVMYVNEKDKQRSSKSDFTSRTRQHRGKDCSMEQMTEIREQQERLARMHFEIGQQQPRHQEKDTSGPGQSSANMRHLLHRLQQLSMCIEKLHNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HCU2</accession>
    <name>A0A8J2HCU2_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to PCIF1: mRNA (2'-O-methyladenosine-N(6)-)-methyltransferase (Homo sapiens)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS7479</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5094978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HCU2"/>
    <dbReference type="OrthoDB" id="193787at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016422">
        <property type="term" value="F:mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099122">
        <property type="term" value="F:RNA polymerase II C-terminal domain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039881">
        <property type="entry name" value="PCIF1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022035">
        <property type="entry name" value="PCIF1_WW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21727:SF0">
        <property type="entry name" value="MRNA (2'-O-METHYLADENOSINE-N(6)-)-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21727">
        <property type="entry name" value="PHOSPHORYLATED CTD INTERACTING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12237">
        <property type="entry name" value="PCIF1_WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00397">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WW" evidence="2">
        <location>
            <begin position="80"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="133"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="667"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="667"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="701"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="726"/>
            <end position="755"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5094978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="755" mass="85135" checksum="CA2F1A59E8E6B630" modified="2022-05-25" version="1">MNEASGGKQELPNTINTTTWDVMSSQGISPVAGTMHHHHNLHHHHPSMMQTLHQDPGSNVSQVIVPTPVKLQPQPMPQTPNIVQGWKKFWSKRENRPYFWNKLTGESLWVMPGTKPQFDPITDPLGICGGGAPVPPGNGPLTPGTPGGPLKRRASEEGNPAVATKKFMLPGPWDLDVPTNVIIFERAPSNLLHVHPDAEALRCSLLSKLRQCYQELCHTRESIDAPKDSFNRWLMERKVIDCGSDPLLPSQCFPEISMSMYREIMNDIPIKIVRPKFTGDARKQLSRYAEAAKKMIESRSASSESRKVVKWNAEDTFQWLRRTVGATFDDFQDRLGHLKRQCQPHLTETVKTSVEGICLKIYNLSTDYAKKVKDKNNQILKDNGLGDVIPLGGPASTQRKVWCYSIQFSLPAPRLPQIEYLPEREQTMLRYHGDTMCINNFHLTKLEHLYRYNCFDDKKFEMFLPRVWCALKRYQTYLGINEGHATQMALPVTVFECLQRSFGVAFECFASPFNCYFRQYCSAFADTDSYFGSRGPFLDFRPISGSFQANPPYCEELMEAMVNHFERLLSDSTESLSFIVFLPEWRDPAPNALIKLESSHFKRKQVVVPAMEHEYRHGFQHILPKGEVNIRAAHGTLVVWLQNAAGTARWGPTEERVEALLEAWRPGRERERDRQELLSPPRQPSHQQIPTTPLPLPSTCPVASPTSPSIATTAPPQSLTIPNAIPSTTAMPTTTTNSPTSTLPPLSSSVTAHPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HCW5</accession>
    <name>A0A8J2HCW5_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to CIR1: Corepressor interacting with RBPJ 1 (Gallus gallus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS5508</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5090157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HCW5"/>
    <dbReference type="OrthoDB" id="6253837at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040014">
        <property type="entry name" value="CIR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019339">
        <property type="entry name" value="CIR_N_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13151">
        <property type="entry name" value="CBF1 INTERACTING COREPRESSOR CIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13151:SF2">
        <property type="entry name" value="COREPRESSOR INTERACTING WITH RBPJ 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10197">
        <property type="entry name" value="Cir_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01083">
        <property type="entry name" value="Cir_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBF1-interacting co-repressor CIR N-terminal" evidence="2">
        <location>
            <begin position="13"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="184"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="191"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="216"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="240"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="262"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5090157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="347" mass="42108" checksum="CB303E726CFBF841" modified="2022-05-25" version="1">MGKGFNNYMCKKFFHPASRDNLKRVWMAEQQADAYKKKQEELRVQYEKEQDLHNNKALLSKESKDKLSVNFMYEPPPGAKKEREKEDNEPEYKFEWQRKYNAPRESYCKGDSEIRDQPFGIQVRNVRCIKCHKWGHINTGNYDEINSYEFINHEDQLLSADEDEMSEEAFFNSLSKKEKKRLIKKLEKMEKKKAKKEKKRKSKKEKKKKSKKRESVSSSSSSSESSDSESESSSSEDEKKRRKKKKSKKTHDSSSSSSDEETIVKEKERSREKDREKFKDRRQEEVRRRDERFDRRPDRRDHGHYYDKESFKDKADYNRDRNRHDRKRKSEESDERRYRRDKRIRNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HCX6</accession>
    <name>A0A8J2HCX6_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="19">Kainate 2 (Xenopus laevis)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">HICCMSTLAB_LOCUS7261</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="15">Postsynaptic cell membrane</location>
            <topology evidence="15">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5093935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HCX6"/>
    <dbReference type="OrthoDB" id="5984008at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045211">
        <property type="term" value="C:postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015276">
        <property type="term" value="F:ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.190.10:FF:000060">
        <property type="entry name" value="Glutamate receptor ionotropic, kainate 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000134">
        <property type="entry name" value="Glutamate receptor, ionotropic kainate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000010">
        <property type="entry name" value="Putative glutamate receptor ionotropic kainate 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.190.10:FF:000147">
        <property type="entry name" value="Uncharacterized protein, isoform C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001828">
        <property type="entry name" value="ANF_lig-bd_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019594">
        <property type="entry name" value="Glu/Gly-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015683">
        <property type="entry name" value="Ionotropic_Glu_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001320">
        <property type="entry name" value="Iontro_rcpt_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18966">
        <property type="entry name" value="IONOTROPIC GLUTAMATE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01094">
        <property type="entry name" value="ANF_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00060">
        <property type="entry name" value="Lig_chan"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10613">
        <property type="entry name" value="Lig_chan-Glu_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00918">
        <property type="entry name" value="Lig_chan-Glu_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00079">
        <property type="entry name" value="PBPe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="Periplasmic binding protein-like I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="14" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="13" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="9 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0628">Postsynaptic cell membrane</keyword>
    <keyword evidence="10" id="KW-0675">Receptor</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0770">Synapse</keyword>
    <keyword evidence="4 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="244"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="366"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="556"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="domain" description="Ionotropic glutamate receptor C-terminal" evidence="17">
        <location>
            <begin position="113"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="domain" description="Ionotropic glutamate receptor L-glutamate and glycine-binding" evidence="18">
        <location>
            <begin position="123"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00034104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM00079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="SMART" id="SM00918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="CAG5093935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="655" mass="74099" checksum="CC37683B1AD18DE4" modified="2022-05-25" version="1">MYDAVHLFAKALHVLDASQQMEIKALSCESSDTWSHGYSLINYMKIVEMNGLTGLIKFDHQGFRSDFMLDIIELNNKEGLKKIGVWNSTEGVNFTRTFSDAYTQIVESLQNKTFIVSTILSAPYFMLKDSSVKLEGNAQYEGYSVDLIHEISRILGFNYTFVIVPDKKYGSYNKKTKEWDGMIKELLDQKADLAIADLTITYDREQAVDFTMPFMNLGISILYRKPIKKPPNLFSFLSPLSLDVWIYMATAYLGVSVLLFILARFTPYEWYNSRPCGKDCDHVQNRFKLINCLWFTIGSLMRQGCDILPKFSPYEWENPSPCNAQPEVCENEFTLLNSLWFTIGSLMQQGSDIAPKAVSTRMVAGMWWFFTLIMISSYTANLAAFLTVERMESPIESAEDLAKQTKIKYGALAGGSTAAFFRDSNFSTYQRMWSFMQSAKPSVFTKSNMEGVEWVIKGKGTYAFLMESTSIEYVIERNCELTRVGTELDSKGYGIAMPPNSPYRTAISSAILKLQEEGKLHTLKTRWWKEKRGGGKCREDNQKAGSTANELGLANVGGVFVVLMGGMGVACVIAVCEFVWKSRKVAVEERKSLHSERTSEMQYSVDSIDCLEKTSSKISCYWDKQRPNLSTVSEVKPPTPGYSKYTHFVGKPPLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HCZ0</accession>
    <name>A0A8J2HCZ0_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS7570</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5095160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HCZ0"/>
    <dbReference type="OrthoDB" id="7695528at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5095160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="202" mass="23098" checksum="9B6C6392FBFF7DC8" modified="2022-05-25" version="1">MIEPAEGTTCGSQKIHDKMTPEELMRIFGISLADEVPEYEAVPIYAKSLDKNNGIYITLNPFGKNLKMWLTPNDGILAGEDMPIVSLKTNKQGLIDITKYSGFIRQALPKLYENKLYAATFAVNNHRTGRMSLVRRFLINKSSKYESFVGDYYVQPVPSRLVKHARRQARAIDDSFDHEEYDHVYHFVHKIPNSKMNKQAGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HDJ9</accession>
    <name>A0A8J2HDJ9_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Cc_bv9.8_32.11b_pseudo</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS6204</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5092535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HDJ9"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5092535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="49" mass="5524" checksum="EC9B9C271B3B75C5" modified="2022-05-25" version="1">MGFERIITCQPALAEWTEYQGVVEREAGESLDRPSTSLIIFPFMVNFSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HDK6</accession>
    <name>A0A8J2HDK6_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Similar to lz: Protein lozenge (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HICCMSTLAB_LOCUS5947</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5092146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HDK6"/>
    <dbReference type="OrthoDB" id="10029800at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001709">
        <property type="term" value="P:cell fate determination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.720:FF:000001">
        <property type="entry name" value="Runt-related transcription factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.720">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000040">
        <property type="entry name" value="AML1_Runt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008967">
        <property type="entry name" value="p53-like_TF_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012346">
        <property type="entry name" value="p53/RUNT-type_TF_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013524">
        <property type="entry name" value="Runt_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11950">
        <property type="entry name" value="RUNT RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11950:SF48">
        <property type="entry name" value="RUNT RELATED B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00853">
        <property type="entry name" value="Runt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00967">
        <property type="entry name" value="ONCOGENEAML1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49417">
        <property type="entry name" value="p53-like transcription factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51062">
        <property type="entry name" value="RUNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Runt" evidence="6">
        <location>
            <begin position="80"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="41"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="247"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="315"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="412"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="41"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="419"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="446"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="467"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="487"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="515"/>
            <end position="572"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAG5092146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="583" mass="64707" checksum="0F88D469EA30B2CF" modified="2022-05-25" version="1">MTNPLRDVRPEERPLGLDYQDQARLRSTQNGNQQINAISSRLRKTRGSSRRRMHLAENPSTTASSAPDYALTADLLAERTLDGLLAEHPGELIRTGSPHVVCTVLPNHWRSNKTLPVAFKVVALGEVGDGTIVTIRAGNDENCCAELRNSTALMKNQVAKFNDLRFVGRSGRGKSFTLTIMLQTSPPQVATLSKAIKVTVDGPREPRSKTRHQAFHPYHFGPRPFPFGHPQDPLGFKLSGLQHLSLEQNGQWGGPPRGSLPPHCLPPPPGHLSQPQHPPTATSAFNPFHHAIEQRSRLPAPGPTESRNELGPLSVSVREAPPTDSPNTGPGLLTTAVASPTPPAEPAAASPSHPHFQSLHLLRANSLFGSIFAPFLPQSSWLYNPLSTYQQQYILEPDWHTLALRMAQQRLQRPGQSLEDLRKLRSSSDDGDQDGDASTDRPQDVGDQDADVDSPEGSIEVDDPSDQDPKIEEVRSEDSQADSPRLSSRDNKDESFLEKRLRPTVENLNDDIEDRLDPEHRHDLTVKIKLEGTVDLSTKRNSDKENMGQDLTTRKKEEDIDEKESVRPRKDISPQPRHVWRPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HE22</accession>
    <name>A0A8J2HE22_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to BTBD2: BTB/POZ domain-containing protein 2 (Homo sapiens)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS8218</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5096455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HE22"/>
    <dbReference type="OrthoDB" id="45365at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022008">
        <property type="term" value="P:neurogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.710.10:FF:000169">
        <property type="entry name" value="BTB/POZ domain-containing protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.820">
        <property type="entry name" value="PHR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011705">
        <property type="entry name" value="BACK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038648">
        <property type="entry name" value="PHR_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45774:SF3">
        <property type="entry name" value="BTB (POZ) DOMAIN-CONTAINING 2B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45774">
        <property type="entry name" value="BTB/POZ DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07707">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00875">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="46"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="288"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5096455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="557" mass="62949" checksum="DA639592C0ECADBD" modified="2022-05-25" version="1">MLYHTDIHIYIYIYILNKMGPPCDWQISKQKIAQRGRYLLESGQWSDCKFIVGQEPQQQILEGHKLFLAMSSPVFEAMFYGSMAEKTDPIPIRDVQPEAFKTLLEYIYTDKVDLGSFELACELCYCAKKYMLPFLVEECTKYLWSDLSPNKACRAYEFAKLFEEPVLMDKCLQIICTKTNEILNEPSWDEVELSTIMTIFEQDELQIDSEIELFVAIERWAKAECNRKSLNPSDAKSSRSVIGNVLSKIRFLTLTPQQFADVPGRSNLLSRDEAFSILMNVSSSGSNIPMPEGFSTNPLHRIKPRRPTGLSNGRSQKYNGVIGRHASPAGLSNHWQIFPSTSYSHTSLINSDTDRTDIDSSWLSYPTTIDFNGRKENGSSTANDNIPTVLVEGGIRDGPKYYCLRSMGQQAEYLNPGVMDCSVTFSVDKNICVIGVQVPTQVACEANQMMRSADGTYTEILYAHLLDSDGSRLTYTHFTTKATAGTLVEIGFNRPVYIQKNKIYRVGVVFNKPGWYPIGDCVQRMTCDTVFFSFGVGNSTDSIRDGLIRSIVFTYHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HEU7</accession>
    <name>A0A8J2HEU7_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS8413</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5096843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HEU7"/>
    <dbReference type="OrthoDB" id="337038at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5096843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="143" mass="16623" checksum="81C96FF219B8B0D2" modified="2022-05-25" version="1" fragment="single">MNEPLVEETVELLQNQNYTNEDNLAKNVIQKEIPNRNRCLSNRRLLSQATIAETSVISNNILQQPLKEFPVINFIHTVRPNWPPSRKREEARVLENLKKLVERSKLFKDNQTSGSEGSTVIQSTQINNEQYKKLENRPQLLTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HEZ6</accession>
    <name>A0A8J2HEZ6_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Similar to AGFG1: Arf-GAP domain and FG repeat-containing protein 1 (Homo sapiens)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HICCMSTLAB_LOCUS8498</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5097013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HEZ6"/>
    <dbReference type="OrthoDB" id="6036at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08838">
        <property type="entry name" value="ArfGap_AGFG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.220.150:FF:000005">
        <property type="entry name" value="Arf-GAP domain and FG repeat-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.150">
        <property type="entry name" value="Arf GTPase activating protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052248">
        <property type="entry name" value="Arf-GAP_FG-repeat_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037278">
        <property type="entry name" value="ARFGAP/RecO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001164">
        <property type="entry name" value="ArfGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038508">
        <property type="entry name" value="ArfGAP_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46134:SF3">
        <property type="entry name" value="ARFGAP WITH FG REPEATS 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46134">
        <property type="entry name" value="DRONGO, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01412">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00405">
        <property type="entry name" value="REVINTRACTNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00105">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57863">
        <property type="entry name" value="ArfGap/RecO-like zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50115">
        <property type="entry name" value="ARFGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Arf-GAP" evidence="7">
        <location>
            <begin position="10"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="131"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="132"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG5097013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="350" mass="38771" checksum="6DD4AC90732EFE94" modified="2022-05-25" version="1">MASAKRKQDEKHLKILRELVSQPGNKECFDCRQRGPTYVNMTIGSFVCTSCSGLLRGLTPPHRVKSISMATFTAEEIEFINQRGNEHCKKIWLGLVNSNTPITIDTKDEQKMKDLMSAKYEHKRYYLDPSMASDNCNNQKAQSASSDRTLRSNQTNVPRVPHVGVLPTLSTPNQKKKTTSEPTPTFTADFVADFSQVPDPFVNSTPASQFPGPIQPQASFANFDNNPAFESPKNLSNAFNSTGKFLSNFNGVNSPPSEDRYAALKDLDSMMKKTQLREDTQAPNVASTWIASNTNRFNTPNSTDVLASSQMMTPLSEKAWHPTVPLYQANPFMVGTGVGNSTRSSNNPFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HFG6</accession>
    <name>A0A8J2HFG6_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Chitin-binding type-2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HICCMSTLAB_LOCUS8436</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5096889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HFG6"/>
    <dbReference type="OrthoDB" id="8197172at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.140.10">
        <property type="entry name" value="Chitin binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002557">
        <property type="entry name" value="Chitin-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036508">
        <property type="entry name" value="Chitin-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051940">
        <property type="entry name" value="Chitin_bind-dev_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23301">
        <property type="entry name" value="CHITIN BINDING PERITROPHIN-A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23301:SF98">
        <property type="entry name" value="CHITIN-BINDING TYPE-2 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01607">
        <property type="entry name" value="CBM_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00494">
        <property type="entry name" value="ChtBD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57625">
        <property type="entry name" value="Invertebrate chitin-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50940">
        <property type="entry name" value="CHIT_BIND_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0147">Chitin-binding</keyword>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Chitin-binding type-2" evidence="6">
        <location>
            <begin position="97"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAG5096889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="378" mass="42688" checksum="2C7461B800C43345" modified="2022-05-25" version="1">MIIHIFFFKLRNAWDDTGFGKEDKQNKSQYDLQNVKLNLNQQAETFIDNSSAQIVSNVRQSYPDFSDLNANQFEQTEIPNLLAESDQARPDDDQMLISGCLAARGQFPSPNNCANYLNCWDNTVIEQQCPNDLLFNEMTGLCDFEQNVNCGERPGPTPKNPETIINKPTLKVYKVKPPPFYVQLPGIKHTTNFLSSGGIPTTDFIVREFDESFTKIFPNNMETYDLIIALLKSKTINYFTYTPRHLKVKTVFLKGVKGGYDEKDVKTALKSLQLPDVKITKYQQLPLACWHPSQDQKHYCRNLLGGRGSESLPYLCAIDASKLVTPALTVICLQSALNMQAIMSPKIAPSHHQWTNQLLSASTVGELVIRQTTDDAQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HFW9</accession>
    <name>A0A8J2HFW9_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS7870</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5095762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HFW9"/>
    <dbReference type="OrthoDB" id="10256829at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035278028" evidence="2">
        <location>
            <begin position="19"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="799"/>
            <end position="817"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5095762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="820" mass="92384" checksum="DFB0526CDF535BDD" modified="2022-05-25" version="1">MRVIAFLIGIGIFSCVQTQENAQRKLSSGLLECYNSSFVVLKDNHLPYTMDTFIAILRKIEDSPSFNMDLRQFTVSLLNRFRQDGIIENTESKPALGVIPYAPNSFQFYKNAAILKLIQGNGLHFPNSSISLLERCALHFILSSTIDFKERGDEPTTCQTQNSPYRWKRNIDKGTGDVETLSPEELEIIKNKNNESKEGDFDPNSFYPVLPPNHPENAQYKQPVTSKCPLESGVIHTKWGTVAGGPLLAGIAAALQPEKIKISDLVFRNWRLNENLSDVRLDNKWLATLAGDLAEVVISQGPFKNLDERFQIGIEGHWNSTVSQKYYFLNEDENVEFTAAEVRGDLDGLILANTVMTWYQSIPSLKLSQIFDMYYSDRGLFNVSTRACDRRALLTSVAPNDTTSAQVYTASLALEKDISTASMSPELINSLSVKATNELFNFIPSSLNNDLGCDANLRSFNRLAVDLTIFIDTNWKFPAIQPILTLLLENCDINKYASNFTLINAFDGNVLINSSNNILDFYSFNETQYSSLTMFKNGFDLPKSLEVLKIREEQKLNREWESKIGGQRSEIVLILPSATASISDSDKTFCLDRLKTLKETVPDATLLFLTPGSKDKWAEMTVDSINDIVSFSNGNTKENSAQIINLVNRMKQVPRRLINTQCGASYTSSGNSESYTNYLEPSGITFYRLHPNYFYKIEEENLPTIKIQSYSGTRLTICTSRDPININVTSSNCVTTDTHSETIYCPDPTYIHECKPFYLSIAANDHSYSPCNAEPERCRYPDMTKYTISYENLVCVSSASSAIISPIVYFITIMYIYTRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HGS7</accession>
    <name>A0A8J2HGS7_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">HICCMSTLAB_LOCUS9069</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5099448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HGS7"/>
    <dbReference type="OrthoDB" id="10258631at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030688">
        <property type="term" value="C:preribosome, small subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05144">
        <property type="entry name" value="RIO2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000307">
        <property type="entry name" value="Serine/threonine-protein kinase RIO2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000052">
        <property type="entry name" value="Serine/threonine-protein kinase RIO2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030484">
        <property type="entry name" value="Rio2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015285">
        <property type="entry name" value="RIO2_wHTH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018934">
        <property type="entry name" value="RIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000687">
        <property type="entry name" value="RIO_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018935">
        <property type="entry name" value="RIO_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45852">
        <property type="entry name" value="SER/THR-PROTEIN KINASE RIO2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45852:SF1">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE RIO2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01163">
        <property type="entry name" value="RIO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09202">
        <property type="entry name" value="Rio2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00090">
        <property type="entry name" value="RIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01245">
        <property type="entry name" value="RIO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 15" id="KW-0418">Kinase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RIO kinase" evidence="14">
        <location>
            <begin position="54"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="305"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="434"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="306"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="434"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CAG5099448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="481" mass="55428" checksum="CC5B6335A2BEFD3D" modified="2022-05-25" version="1">MGKLDVVMLRYLSAEDFRVLTAIEMGMKNHELVPAMLAAQIANLKHGGVSKILRELSKHKLVSYERYDYLALKVLSTREVLSSFGNQIGVGKESNIYVVADKDDKPLCLKLHRLGRTCFRNIKGKRDYHQNRKSMSWLYLSRISATREFAYMKALQDRGFPVPKPIDFNRHCVVMELVNGYPLCTISEIENPDELYDELMNLIVRFGNHGVIHGDFNEFNIMVTDKGKPIIIDFPQMVSTEHLNAEYFFDRDVNCVRSFFKRKFGYESELYPSFKDICREGCIDAEVKASGLTRQMEKDLLVEMGQIDEDEDSDDDDDDDDDDESNEEKPLDSITEIKLLRNQVNESVAKDLNEKINILSDNDVNEDDDNLDESVVKDLSDKLRIQMIDQEDHESELADQVPDLIEDDRESRFDSHSTWSTTSTIDPAVIKQRVKQSLKKRERHGQSRRVLAKGEASTTTRQRRDNRDTIKQYTDGGVWGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HI01</accession>
    <name>A0A8J2HI01_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Eukaryotic translation initiation factor 3 subunit F</fullName>
            <shortName evidence="5">eIF3f</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Eukaryotic translation initiation factor 3 subunit 5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HICCMSTLAB_LOCUS8131</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.</text>
    </comment>
    <comment type="function">
        <text evidence="4">Deubiquitinates activated NOTCH1, promoting its nuclear import, thereby acting as a positive regulator of Notch signaling.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the eIF-3 subunit F family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5096281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HI01"/>
    <dbReference type="OrthoDB" id="25498at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071541">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex, eIF3m"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0101005">
        <property type="term" value="F:deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031369">
        <property type="term" value="F:translation initiation factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd08064">
        <property type="entry name" value="MPN_eIF3f"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.10:FF:000014">
        <property type="entry name" value="Eukaryotic translation initiation factor 3 subunit F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03005">
        <property type="entry name" value="eIF3f"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027531">
        <property type="entry name" value="eIF3f"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024969">
        <property type="entry name" value="EIF3F/CSN6-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000555">
        <property type="entry name" value="JAMM/MPN+_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10540:SF6">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10540">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01398">
        <property type="entry name" value="JAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13012">
        <property type="entry name" value="MitMem_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00232">
        <property type="entry name" value="JAB_MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 5 7" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3 5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MPN" evidence="6">
        <location>
            <begin position="7"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00059951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAG5096281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="282" mass="31211" checksum="68057C2E3EC3A61C" modified="2022-05-25" version="1">MALDLVVKVHPVVLFQIVDAFERRNSDSHRVIGTLLGTVEKGVVEVTNCFCVPHKESDDQVEAELSYAMDLYDLNHRVNAQENIVGWWATGKEVTTHSSVIHEYYARECNNPVHLTVDTTLVNTTRMGIKAYVCVQLGVPNGKQGCMFTPTKVEITCYEPEIVGLQLCQKTQKAPSGQTKLGGGVEPMMDLAQIAEASSKLATMLEQVLAYVDNVLDGKQPPDNQVGRALLDMVNSVPKMTSDQFDEMFNSNVKDLLMVVALSQLIKTQLQLNEKLTLLTTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HIR8</accession>
    <name>A0A8J2HIR8_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS6277</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5092645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HIR8"/>
    <dbReference type="OrthoDB" id="7688248at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035170679" evidence="1">
        <location>
            <begin position="19"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5092645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="165" mass="18598" checksum="032647C5B20E4DC7" modified="2022-05-25" version="1">MILSALIVLTAQFFSVQGDFVVLLKDIDCPLFNEEYFTEPDTYIDDNNAIFFNTTIVKEFLPLTQGYLGIIGASLGEYVVNTGIDVEMTLCDMMNEPVIMGPLLRVFGFSDDNCPPKPGVYGSEGYTLPTATFPDDFPRNQYKAVFKLTNEDEELIILNIYFEIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HIT4</accession>
    <name>A0A8J2HIT4_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS11089</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5102586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HIT4"/>
    <dbReference type="OrthoDB" id="8186940at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006631">
        <property type="entry name" value="DM4_12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21398:SF4">
        <property type="entry name" value="AGAP002980-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21398">
        <property type="entry name" value="AGAP007094-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07841">
        <property type="entry name" value="DM4_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00718">
        <property type="entry name" value="DM4_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5102586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="224" mass="25266" checksum="7DC1EA1200DFFD6A" modified="2022-05-25" version="1" fragment="single">FTIGVSVPLLATNKKGNVVFSAGFQFNYALPWNLTQLQSPSIIPSRHTDDFNLNNIYLSIENLFDRLKYSLYLTCPIHSVVDVAETLSQCHCCHRSSSSFYIFLFLFLFFFFSSSSCSLSRQDEPLIICHSVYNWSDGRQCLLRSICELAETPLNRVNTDVLVDVVHLLLTPSEDLPETVNSSHRSIDKLYHRAELLGKSGGDCASSYPGCAESPLKYFTQIDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HIU4</accession>
    <name>A0A8J2HIU4_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="22">Similar to CadN: Neural-cadherin (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">HICCMSTLAB_LOCUS8610</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="16">Cadherins are calcium-dependent cell adhesion proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 15">Cell membrane</location>
            <topology evidence="1 15">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5097243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6079678at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016342">
        <property type="term" value="C:catenin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008013">
        <property type="term" value="F:beta-catenin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045296">
        <property type="term" value="F:cadherin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048846">
        <property type="term" value="P:axon extension involved in axon guidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016318">
        <property type="term" value="P:ommatidial rotation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045467">
        <property type="term" value="P:R7 cell development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045463">
        <property type="term" value="P:R8 cell development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd11304">
        <property type="entry name" value="Cadherin_repeat"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="CDD" id="cd00053">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd00110">
        <property type="entry name" value="LamG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000182">
        <property type="entry name" value="Blast:Putative neural-cadherin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.900.10:FF:000001">
        <property type="entry name" value="Cadherin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000039">
        <property type="entry name" value="FAT atypical cadherin 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000417">
        <property type="entry name" value="neural-cadherin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000040">
        <property type="entry name" value="neural-cadherin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000044">
        <property type="entry name" value="neural-cadherin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000112">
        <property type="entry name" value="neural-cadherin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000213">
        <property type="entry name" value="neural-cadherin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000312">
        <property type="entry name" value="neural-cadherin isoform X10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000109">
        <property type="entry name" value="neural-cadherin isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000128">
        <property type="entry name" value="neural-cadherin isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.60">
        <property type="entry name" value="Cadherins"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.900.10">
        <property type="entry name" value="TCF3-CBD (Catenin binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039808">
        <property type="entry name" value="Cadherin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002126">
        <property type="entry name" value="Cadherin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015919">
        <property type="entry name" value="Cadherin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020894">
        <property type="entry name" value="Cadherin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000233">
        <property type="entry name" value="Cadherin_Y-type_LIR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027397">
        <property type="entry name" value="Catenin-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013032">
        <property type="entry name" value="EGF-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001791">
        <property type="entry name" value="Laminin_G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056370">
        <property type="entry name" value="Shg-like_Ig-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24027:SF438">
        <property type="entry name" value="CADHERIN 23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24027">
        <property type="entry name" value="CADHERIN-23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01049">
        <property type="entry name" value="CADH_Y-type_LIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00028">
        <property type="entry name" value="Cadherin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00008">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12661">
        <property type="entry name" value="hEGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24811">
        <property type="entry name" value="Ig_Shg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02210">
        <property type="entry name" value="Laminin_G_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00205">
        <property type="entry name" value="CADHERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00112">
        <property type="entry name" value="CA"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00282">
        <property type="entry name" value="LamG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49313">
        <property type="entry name" value="Cadherin-like"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00232">
        <property type="entry name" value="CADHERIN_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50268">
        <property type="entry name" value="CADHERIN_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50025">
        <property type="entry name" value="LAM_G_DOMAIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 13 15" id="KW-0106">Calcium</keyword>
    <keyword evidence="8 15" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11 14" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 14" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 15 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 18" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="1534"/>
            <end position="1557"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="21">
        <location>
            <begin position="39"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="21">
        <location>
            <begin position="139"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="21">
        <location>
            <begin position="255"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="21">
        <location>
            <begin position="367"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="21">
        <location>
            <begin position="486"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="21">
        <location>
            <begin position="590"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="20">
        <location>
            <begin position="961"/>
            <end position="997"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin G" evidence="19">
        <location>
            <begin position="998"/>
            <end position="1204"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="20">
        <location>
            <begin position="1207"/>
            <end position="1247"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin G" evidence="19">
        <location>
            <begin position="1250"/>
            <end position="1441"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="20">
        <location>
            <begin position="1484"/>
            <end position="1522"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1638"/>
            <end position="1657"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="987"/>
            <end position="996"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="1237"/>
            <end position="1246"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="1493"/>
            <end position="1510"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="1512"/>
            <end position="1521"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU003318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU004357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="CAG5097243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="1708" mass="191682" checksum="8986A516BB2FEBA5" modified="2022-05-25" version="1">MDLRELESVPKTLASQLPTLTKFIRIGIADKNDNPPYFDKSLYEAEVDENEDIQHTVLTVTAKDHDESSRIRYEITSGNIGGAFAVKNMTGAIYVAGALDYETRKRYELKLTASDNLRENYTTVVIHVKDVNDNPPVFERPTYRTQITEEDDRNLPKRVLQVMATDGDKDRPQNIVYFLTGQGIDPNNPANSKFDINRTTGEIYVLKPLDRDQPNGRPQWRFTVFAQDEGGEGLVGYADVQVNLKDINDNAPIFPQGVYHGNVTENGTAGMLVMTMTAVDYDDPSEGTNAKLIYSIEKNVIEEETGSPIFEIEPDTGVIKTAVCCLDRERTPDYSIQIVAVDGGSLKGTGTASIRVKDINDMPPQFTKEEWLTEVDETDGTNLPEMPILTVTVHDDDETNKFQYKVLDDSGFGADKFTMVRNNDGTGSLKIVQPLDFENQLQSNGFRFKIQVNDKGEDNDNDKYHVAYSWVVVKLRDINDNKPQFDKSNIETTVLENAEVGNSLETFKATDPDQGGNSKVSYAIDRSSDRKRQFHINENGTVTIQRSLDREETPRHQVKILAIDDGIPPKTATATLTVIVTDINDNPPTFLKDYRPVLPEYAMPRKVIEILATDDDDRSRSNGPPFTFRMDPNADDIIRASFKVESDNKGANGDGMAIVSSLRSFDREVQKEYLIPIIIKDSGTPLMAGTSTLTVVIGDVNDNKMQPGSKDIFGQSPDTEIGRVYVYDLDDWDLPDKKFYWEGLEHAQFKLDEDSGMISMKSGTHDGKYHLRFKVYDRKHTQTDVPANVTVTVKTIPHEAVMNSGSVRLSGISDEDFIRVWDYKNQRLMRSKADLFKDKLALLLDIERENVDVFSVQQRRKYPPLTDVRFAAHGSPYYKAVRLNGMVLMHREEIEKEIGINITMVGIDECLYENEVCEGSCTNILDINNQPYMVNANKTALVGVRVDVIAQCTCGARNFTTTESCRNSPCYNGGRCIEGRYGLTCQCPAGYNGPRCQQTARSFRGNGWAWYPALEMCDNSHLSFEFITRKPDGLLLYNGPIVKPESDEVMVSDFISVELERGVPRLLIDFGSGTLELKVKTKRPLDDGEWHRLDIFWTTETVKLIVDFCKSAEISEQEDGTPPTLDGTSCQATGAVPPFNEYLNVNAPLQLGGSYMEHFEPSHYKWKSRPMNKGFDGCIRNLFHNSKLYDLAHPGLSKHSVAGCPPTDEICGNQESTLRCWEHGTCVGSFTEARCQCNPGWTGPGCMTQTIPTTFKQQSYVKYALSFEPDKYSTQIQLRFRTRENHGELFRVSDQHNREYAILEIKGSRLQFRYNLNSLRVEERDIWLSAITVDDGQWHTVRVSRYGSAATLELDGGEGRRFNETFSFEGHQWLLVDKQEGVYAGGKAEYTGVRTFEVYADYQKGCLDDIRLEGKHLPLPPAMNGTQWGQATMARNLERMCPSNKPCNNVLCPEPFECIDLWNEHACTCGEGKVRSPDGKGCTDKNECIDYPCLNGGRCINQDPRLRYRCICPDGFWGENCELVQEGQTLKLSMGALAAILVCLLVILVLVLVFVVINRRREAHIKYPGPDDDVRENIINYDDEGGGEDDMTAFDITPLQIPIGGPIPDMGGKLLSCKAAYSLGPEPNIGIFIEDHKKRADSDPNAPPFDDLRNYAYEGGGSTAGSLSSLASGTDDEQHEYEYLGAWGPRFDKLADMYGPADESEEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HIY5</accession>
    <name>A0A8J2HIY5_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS11212</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5102844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HIY5"/>
    <dbReference type="OrthoDB" id="7698948at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="entry name" value="Intergrase catalytic core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="DNA breaking-rejoining enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5102844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="131" mass="15397" checksum="57DFE1A40A3DDDAA" modified="2022-05-25" version="1" fragment="single">MLKSTISSKHNIDISQYLRLQAFLKKQSIAFQSEKSKVFSLEEINKFIREASDEKLLFKKVVAILGVLAACREEELCDLKVKSFQEYDGKLLKVDLKDRKTHEDRSFTIKGEFLRIIKNYINLRPKNFEHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HJJ5</accession>
    <name>A0A8J2HJJ5_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Similar to Tmem14c: Transmembrane protein 14C (Mus musculus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HICCMSTLAB_LOCUS9202</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5099723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HJJ5"/>
    <dbReference type="OrthoDB" id="5620at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070453">
        <property type="term" value="P:regulation of heme biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1740">
        <property type="entry name" value="Transmembrane protein 14-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005349">
        <property type="entry name" value="TMEM14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044890">
        <property type="entry name" value="TMEM14_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12668:SF43">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 14 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12668">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 14, 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03647">
        <property type="entry name" value="Tmemb_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="5"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="28"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="79"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAG5099723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="110" mass="11389" checksum="D855962D0722FDBB" modified="2022-05-25" version="1">MPIDYAAFAYAASVAGGGILGYVKSKSIPSLAAGLLFGTILGFGAYQTSQDPRNCAVLLGSSATLGGMMGYRYYNTGKIMPAGAIAIISAVMFIRTVVKTVTTPQVQKVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HKA7</accession>
    <name>A0A8J2HKA7_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Dynein heavy chain, cytoplasmic</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Dynein heavy chain, cytosolic</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">HICCMSTLAB_LOCUS7292</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subunit">
        <text evidence="3">Consists of at least two heavy chains and a number of intermediate and light chains.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the dynein heavy chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5093966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="14187at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904115">
        <property type="term" value="C:axon cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005858">
        <property type="term" value="C:axonemal dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045505">
        <property type="term" value="F:dynein intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051959">
        <property type="term" value="F:dynein light intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008569">
        <property type="term" value="F:minus-end-directed microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048469">
        <property type="term" value="P:cell maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051642">
        <property type="term" value="P:centrosome localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051293">
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        <property type="entry name" value="Dynein_heavy_D6_P-loop"/>
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        <property type="entry name" value="Dynein_heavy"/>
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        <property type="entry name" value="MT"/>
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        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11 15" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="10" id="KW-0243">Dynein</keyword>
    <keyword evidence="6" id="KW-0493">Microtubule</keyword>
    <keyword evidence="12" id="KW-0505">Motor protein</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="16">
        <location>
            <begin position="1897"/>
            <end position="2049"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="16">
        <location>
            <begin position="2214"/>
            <end position="2365"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="16">
        <location>
            <begin position="2586"/>
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        </location>
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        <location>
            <begin position="2928"/>
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        </location>
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        <location>
            <begin position="541"/>
            <end position="568"/>
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        <location>
            <begin position="1275"/>
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        </location>
    </feature>
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        <location>
            <begin position="3207"/>
            <end position="3252"/>
        </location>
    </feature>
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        <location>
            <begin position="3377"/>
            <end position="3429"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00008887"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00011655"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00033439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CAG5093966.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="4631" mass="529410" checksum="AE9E5281D3AFF31A" modified="2022-05-25" version="1">[encoded data, 4631 characters]</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HKJ3</accession>
    <name>A0A8J2HKJ3_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS7490</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5095000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HKJ3"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5095000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="112" mass="12713" checksum="D5B9DBCAF826D9A2" modified="2022-05-25" version="1" fragment="single">YDKLIKTSLYLINYFLKIILVSLCSSKENKRPALNLDNLDDHNSWQIIWWKRKLPDKSILYIPVGAPKGNKNATTLPFWAVGSGTTRRLNSLPLACGLCGPFSVTGSRYYSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HKR1</accession>
    <name>A0A8J2HKR1_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS9708</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5100635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HKR1"/>
    <dbReference type="OrthoDB" id="8194903at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579">
        <property type="entry name" value="F5/8 TYPE C DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579:SF1">
        <property type="entry name" value="F5_8 TYPE C DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5100635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="678" mass="78197" checksum="1188249BB7979E44" modified="2022-05-25" version="1">MKRGPYKLYLTPEVPEHGNLSSETVDRTEVSYFHDLNFKRSSSNSWLYEDYDDESLLEEIWFDAEDSSLTDDFYVDYNNEHSQQKDEEKDASFDYNRPLCKCTTITQGEALMMTLALGVEESLTWKTIVGILSMINTLFENDVVPSSKYKLFKTLKLSEDILAYHVYCRDCHHYFGSQDKFNKNGLQCPICDNSEKSPDISYFLTFDISLQLKSILEDPKFIPICAVVDSVARCKILNMKQYNGSYGCTFCEHPGLRMNNSQKFPITTVVPKERTNESVKEQMLLAGESEFGSDVMGVWGPSALINLNYYDIVDGMSPDYMHAILLGVIKQHTEILLSSFGEDYYVGSPNQLEAINIKLLNFKHPTCITRSPRNLTEREMWKATEWRSWLLFYSLICLKDILPQKYLEHLALLVEAINQFSQFCERNLTGRLKNTFEVDGCILIGKGTNYNLNDNERKLVNRSETCKSFNRFIYNGKRYTSKNYRACAKTNDSIISLENGKIGIIKNVCLFNSDKGEKKIYIFFEEVVRLKKYFHSSRYVTVNNIEECLITEELNICEAKMISQPCMLTPVKNKHYVIFIPPGCYEVIKAAREKVNCSNCADRLEITKKLIEITDNLVKTAHTKVSCSHCVDKLHLIDDLLKTAYTKVSCLNCVDNLNLNQKLLEITQKFQKLELRFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HKV1</accession>
    <name>A0A8J2HKV1_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">Ribosome production factor 2 homolog</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5 6">Ribosome biogenesis protein RPF2 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HICCMSTLAB_LOCUS9524</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
            <location evidence="1 6">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the RPF2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5100379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HKV1"/>
    <dbReference type="OrthoDB" id="407658at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007109">
        <property type="entry name" value="Brix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039770">
        <property type="entry name" value="Rpf2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12728">
        <property type="entry name" value="BRIX DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12728:SF0">
        <property type="entry name" value="RIBOSOME PRODUCTION FACTOR 2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04427">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00879">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50833">
        <property type="entry name" value="BRIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Brix" evidence="8">
        <location>
            <begin position="31"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="279"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="279"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00030889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU367086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAG5100379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="309" mass="35560" checksum="73A215BE8CBBF9CA" modified="2022-05-25" version="1">MSITPRVVKPKSAKSKRAILKKEPKLIEDAKEAIFLKGQTASKYAFDAMKDLYKLKSPGGLIMQKKNDILPFENIAPIEKFCKKYNAPLFMFVSNNKKRPHNLIMGRTFEHSLLDMVEFGVENYKGLNEFKIDKISSGLKPMLVFNGDLFENNDLYSKIKNLFIDMFQREIVDNIRLQGLEQVLSFTAVDGKIHLRNYKVLLKKSSTRVPRIELVEIGPSMDLAVRRSKLASDDLFKQSCKKPKEYKIKAKKNISSDNFGTKFGRIHLGVQHIDKIQTRKMKGLKKRKITEESDDKNKKAKLTNNDDKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HLG2</accession>
    <name>A0A8J2HLG2_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Olfactory receptor 44</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HICCMSTLAB_LOCUS10627</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5101725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HLG2"/>
    <dbReference type="OrthoDB" id="6604226at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005549">
        <property type="term" value="F:odorant binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004984">
        <property type="term" value="F:olfactory receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004117">
        <property type="entry name" value="7tm6_olfct_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21137">
        <property type="entry name" value="ODORANT RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21137:SF35">
        <property type="entry name" value="ODORANT RECEPTOR 19A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02949">
        <property type="entry name" value="7tm_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0552">Olfaction</keyword>
    <keyword evidence="8 11" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="9" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="24"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="54"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="118"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="161"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="289"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="316"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAG5101725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="415" mass="47728" checksum="780901DD12E3BA00" modified="2022-05-25" version="1" fragment="single">IFRVTGIWPLETNVPTVFRLVHHIFRLVNLTLFLSLLTSSLADSANNIRDLTAFTENLCFFFGTGMTLVKALIFCARRKTILKFIEEIYGPIDLLHQSTDSQVLTTINVTAHQELKEFYFLCVLVSSMGLARIASGRKTENGLPLPTYYPFDTSKPPIYQIIYLCESFCITFNLMVVMITDFTVICFIKWLTVSLKIISSNYKNCDSNSVKRSIFTATSYPKMIKATQKIDIDIEQIDIQSFVSYEQVHDYDVNNNSTDCFEERLKFCIRQHQKIITIVDDLNIIFGRYMFLQVATSTGLICLNGFQVIVCKDSSTVVRFLISLIASFVQLLFWCWYGNKFVSMADTLITSQWMSGWENSFNRSIKKLLVISMIQSLRPLEFHALGLIRFTIPTFVDIVRKSYSVFILLKRTISD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HLW2</accession>
    <name>A0A8J2HLW2_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Similar to Smyd4: SET and MYND domain-containing protein 4 (Mus musculus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HICCMSTLAB_LOCUS8490</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5096997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HLW2"/>
    <dbReference type="OrthoDB" id="7770870at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042826">
        <property type="term" value="F:histone deacetylase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008170">
        <property type="term" value="F:N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008276">
        <property type="term" value="F:protein methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052097">
        <property type="entry name" value="SET-MYND_domain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46165">
        <property type="entry name" value="SET AND MYND DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46165:SF6">
        <property type="entry name" value="SET AND MYND DOMAIN-CONTAINING PROTEIN 4-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01753">
        <property type="entry name" value="zf-MYND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50865">
        <property type="entry name" value="ZF_MYND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SET" evidence="8">
        <location>
            <begin position="203"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="domain" description="MYND-type" evidence="9">
        <location>
            <begin position="255"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAG5096997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="617" mass="70824" checksum="5AE89A9F02823E61" modified="2022-05-25" version="1">MEDHLVQKILSMMNNKPKEETNWEKLFEENLQQMINNGGIPIKNESKDEEIATKKINVGNKMISIAPLNEVIKIYNEAVAYALPGSEVLARAFANRSAVLTNGAMYEDSLKDIERTLKIGYPDNLKAKLYARKAKNLLALNQKMCPEVEEAIAQANMWIEKMDDSNKKKVLSSLDQLQTQSLKKPVKKWDDSLFMPKITSENPKILRASHAIDIQQSEKFGRQIVATKDIKAGEAVVIHKAYSTTLLTEYWHTFCWNCVKFTFSCVPCNQCTNFVYCDENCRDEAWEDHHEIECQVINSLVAYNKKNIEVNLVSLRLLIRALKEYGNVETLYKKVQDLEQIEDTIDKSLTGGIFDDSKYASIYALLRKDINLIESELFTRKSIETLYMLAATTEIFGKKINKMSELKNMKYAIFIAKLLIHHIAIARTNSMMMMPNDDKGNMIRSCGVLLSLLSLFNHSCDCNAYQYASGNISAVVTLQPIKKGEQICISYGMYYRDAPTQVRRQSLKLKHHFWCKCMPCNKNWNPNYKQPSCIMQNGARKNVHKLVSMIQKYDKFPPIVKSYQISTRDKSPTDILRTITEITDLLNSYGKYFNYPCAEIEQAKNLLLNILHWVGGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HM43</accession>
    <name>A0A8J2HM43_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Similar to AhcyL1: Adenosylhomocysteinase-like 1 (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HICCMSTLAB_LOCUS10189</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the adenosylhomocysteinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5101116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HM43"/>
    <dbReference type="OrthoDB" id="10007170at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033353">
        <property type="term" value="P:S-adenosylmethionine cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00401">
        <property type="entry name" value="SAHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000035">
        <property type="entry name" value="Adenosylhomocysteinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1480">
        <property type="entry name" value="Adenosylhomocysteinase-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042172">
        <property type="entry name" value="Adenosylhomocyst_ase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000043">
        <property type="entry name" value="Adenosylhomocysteinase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015878">
        <property type="entry name" value="Ado_hCys_hydrolase_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020082">
        <property type="entry name" value="S-Ado-L-homoCys_hydrolase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23420">
        <property type="entry name" value="ADENOSYLHOMOCYSTEINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23420:SF0">
        <property type="entry name" value="ADENOSYLHOMOCYSTEINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05221">
        <property type="entry name" value="AdoHcyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00670">
        <property type="entry name" value="AdoHcyase_NAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00996">
        <property type="entry name" value="AdoHcyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00997">
        <property type="entry name" value="AdoHcyase_NAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00738">
        <property type="entry name" value="ADOHCYASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00739">
        <property type="entry name" value="ADOHCYASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0520">NAD</keyword>
    <keyword evidence="3" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035262318" evidence="6">
        <location>
            <begin position="19"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="domain" description="S-adenosyl-L-homocysteine hydrolase NAD binding" evidence="7">
        <location>
            <begin position="262"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="17"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="25"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="47"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="84"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG5101116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="489" mass="53686" checksum="C5A114612C72D707" modified="2022-05-25" version="1">MYISVCLLTMLTLRGVSKMADNGDGPSNTSSGKNTRINVSDGPITDPASTIKSLEASNNAFHGPRTKLESKSGALKKSSRYRSRSLSASSNDSYSSASYTGSSSGEDDVSPREKIQKTEKGFTDFCVRNINQYAFGRREIEIAEQEMPGIMALRRRAAEDRPLKNAKIVGCTHINAQTAVLIETLVELGAQVRWAACNIYSTQNEVAAALAHAGYPIFAWRGETEEDFWWCIDKLYQLSKAGKLSVPAMNVNDSVTKTKFDNLYSCRESIIDSLKRSTDVMFGGKQVVICGYGEVGKGCCQALKGLGCIVYITEIDPICALQASMDGFRVMKLNEVIRNVDIVITATGNKNVVTREHMDKMKNGCVICNMGHSNTEIDVNSLRTPDLTWEKVRSQVDHVIWPDGKRIVLLAQGRLVNLSCSSIPSFVVSITAATQALALIELFNAPAGHEYVASLHLPTFDAHLTELTDEQAKYMGLNKAGPFKPNYYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HMI4</accession>
    <name>A0A8J2HMI4_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS11991</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5104416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HMI4"/>
    <dbReference type="OrthoDB" id="6621371at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000987">
        <property type="term" value="F:cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042594">
        <property type="term" value="P:response to starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14596">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14596:SF72">
        <property type="entry name" value="ZINC FINGER PROTEIN MSN2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="102"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="490"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="578"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="617"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="848"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="992"/>
            <end position="1072"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="18"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="621"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1053"/>
            <end position="1066"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5104416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="1168" mass="131017" checksum="7B2EB08D82713B9A" modified="2022-05-25" version="1">MHITHMKCHSRCKTGRMSSASGNNSLASATSYSGASTLTGGVGGALSLMGCVREASPPPQNHRTLDLGDLAMQRHADLLPKEPKKRRFHPLRGLRRIFRRKSRSAADAAFDSHNDRNDPVTHDREDMTLRHPAGRTEDARSQSASELLTDSCDCQSGFLRRGGGVQETFTKLRGASGQLSVSHDSVFPGEVPHTRPLSSLDTLATFQRRQGKTNDEANKSHGIHGASNNRISLRVLEQIKTAIESRNQLASAETHVPLSRFSRTDKRERTDREEPEEKFRLFVKHLFIKPTQHSLLGASQHLAPSSVSPAGLPASPLIIKFPAEVDCELRIIKRLKVTTLSTGLRLTPGQFLFCKMRPSGTKKNILLLYLCWISEQMQVTEASFSCIKKMVVSRETSISTNIRAIIEQLNLNPVERRRLIDRTRETVRIRPVSSPANITIGVYGCNDKTSVDTRTKSTVDIFPEVKIDSRIIAGENNNSKIYPAEISVTNNNNNNNNNNNNNNNNNNNNNNNRYIKETITTPSSAKIIISIWGSNDGKKKEPRVIERTSSCTGKIDIKVVDDEEKRVLFRSRRAEMRQRIPEDQKEPCDEIPRTQPDNDKIATLPKEDLPEFESDSLNHTAAHHRISVRPKNRRPPRRSVTATNSSMSCSTITTISENSDVLDSLEMSTVTSSNASTPIDSKGITVMRKSSSRMSSRTSDLFEEFDVKKKPSSMASLSPDSLDVSITRINEQTDAIGQQDASGDIKYISRKSSGNRQVTTTKLSNVYDELEVTPKKRTSITRLSKSPDSLDNSFSKSSEGFDKLIEDEEVLPTFGRLQSLISKSTDGFDKLAEHVDIKPMPRRLTNMISKSTDGFDTSDREEPRPARRPNNLGYKFSDTVSKSSDSLEAIQALVSDDSIERRRSSFEIRPRRTHKTMSMSSDNFGSLDHHQPELQKISSTSDVYLARVNKSYGKMGSVSKSTDNFEAIDSQETSRSNIDFKHNYKSYKRTISSESSDNLELEDKVETRKVRKPPKKIPNSVLGLYPGDDYDKEDYDRRPCLLRKPPTPRLQKSSESSELGNSKSLNYSDKPYWRKSSESKENIDIHQLLTIVNGNNQRNSVPFTKKLTTSPPSSPVVKQEDNKLLFNNLLTSKNDEELQNMLNGNISEVSTDTKSFKEKLIMFEKLGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HMN1</accession>
    <name>A0A8J2HMN1_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">peptidyl-tRNA hydrolase</fullName>
            <ecNumber evidence="1">3.1.1.29</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HICCMSTLAB_LOCUS10432</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>an N-acyl-L-alpha-aminoacyl-tRNA + H2O = an N-acyl-L-amino acid + a tRNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:54448"/>
            <dbReference type="Rhea" id="RHEA-COMP:10123"/>
            <dbReference type="Rhea" id="RHEA-COMP:13883"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:59874"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:138191"/>
            <dbReference type="EC" id="3.1.1.29"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PTH2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.29" evidence="1"/>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5101359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HMN1"/>
    <dbReference type="OrthoDB" id="1733656at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004045">
        <property type="term" value="F:peptidyl-tRNA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd02430">
        <property type="entry name" value="PTH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1490.10:FF:000001">
        <property type="entry name" value="Peptidyl-tRNA hydrolase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1490.10">
        <property type="entry name" value="Bit1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023476">
        <property type="entry name" value="Pep_tRNA_hydro_II_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002833">
        <property type="entry name" value="PTH2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00283">
        <property type="entry name" value="arch_pth2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003314">
        <property type="entry name" value="PRK04322.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12649">
        <property type="entry name" value="PEPTIDYL-TRNA HYDROLASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12649:SF11">
        <property type="entry name" value="PEPTIDYL-TRNA HYDROLASE 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01981">
        <property type="entry name" value="PTH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102462">
        <property type="entry name" value="Peptidyl-tRNA hydrolase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAG5101359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="169" mass="18768" checksum="BF1B32475D3C378A" modified="2022-05-25" version="1">MSTQVKKNLQEEDFEDPVERMLKKTGCIELHYDVQFLRRLKYLVTKGLPKEPYKMVLVVRTDISMSTGKIAGQCAHAAVECYDSCKNNKVNQEYLDAWFMLGQPKIVLRVTSEDRLKSLAVKASNCGLVTAIIKDAGRTQLEPGTISVLGIGPGPNSIVDSVTSHLKLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HNN6</accession>
    <name>A0A8J2HNN6_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">WD repeat-containing protein 37</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HICCMSTLAB_LOCUS12882</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5107715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HNN6"/>
    <dbReference type="OrthoDB" id="9984207at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19855:SF12">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19855">
        <property type="entry name" value="WD40 REPEAT PROTEIN 12, 37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 8" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="217"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="295"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="337"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="380"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="110"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="261"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="24"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="263"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00040954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAG5107715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="508" mass="56320" checksum="6F4963351A19A214" modified="2022-05-25" version="1">MPGEPPTSTGTKSSSKVKRISIPRVQSSTDTELQSQLSQSGSTPLQPMAFHHLNFRTDFEDSSIPPAVHSRLFDLFQQIHKEFEMVYLENIGLQEKIDALNERLERECYGSGERSLPPGDFQDYSDYSKNPFKPKSTPSSAQKIKASHKLKAQTSKIVSSFKNPTMTCTMHRQYAGHKDGVWEISVGRPGQPIIATASADHTARVIAMDSGRCLLQYIGHSGSVNSIRFHPTIDLALTASGDCTAHIWQAAVNWDVAKRQSSSEDLSADRTPTNASCLGDDNEDLPTLRTPVRELLGHSGVVMAADWLPGADQLVTASWDRTANLYDTETGEIIHTLCGHDQELTYVSTHHAQRLCVTASRDSTFRLWDFREPIHSVSVFQGHTEAVTSAVFTREDKIVSGSDDRSVKVWELRNIRSPLATIRGDSAANRLAVSSNGVVAIPHDNRQIRLFDLSGQRLARLPRTSRRGHRRMVCAVAWAEEPGSICNLFSCGFDRLVLGWNVLPFKDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HQ35</accession>
    <name>A0A8J2HQ35_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS12302</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5106523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HQ35"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5106523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="63" mass="6530" checksum="8E06CE77F7D7F81B" modified="2022-05-25" version="1">MIQGKNQLGIGVACSARRFSWRQSKVQSAAPVRQPRPSVLGARPDGVATPTGVSTPGGDLVIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HQ55</accession>
    <name>A0A8J2HQ55_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Similar to SMAP2: Stromal membrane-associated protein 2 (Homo sapiens)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HICCMSTLAB_LOCUS13168</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5108299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HQ55"/>
    <dbReference type="OrthoDB" id="73919at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08839">
        <property type="entry name" value="ArfGap_SMAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.220.150:FF:000009">
        <property type="entry name" value="stromal membrane-associated protein 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.150">
        <property type="entry name" value="Arf GTPase activating protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051718">
        <property type="entry name" value="ARF_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037278">
        <property type="entry name" value="ARFGAP/RecO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001164">
        <property type="entry name" value="ArfGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038508">
        <property type="entry name" value="ArfGAP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044732">
        <property type="entry name" value="ArfGAP_SMAP1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45705">
        <property type="entry name" value="FI20236P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45705:SF1">
        <property type="entry name" value="FI20236P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01412">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00405">
        <property type="entry name" value="REVINTRACTNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00105">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57863">
        <property type="entry name" value="ArfGap/RecO-like zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50115">
        <property type="entry name" value="ARFGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Arf-GAP" evidence="7">
        <location>
            <begin position="18"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="152"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="242"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="185"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="213"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="242"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG5108299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="534" mass="58631" checksum="5B72E1D816877906" modified="2022-05-25" version="1">MTSRSEKERTKQIQDKCQDLLTQMLRDEDNKYCVDCDAKGPRWASWNLGIFLCIRCAGIHRNLGVHISKVKSVNLDTWTPEQVVSLQQMGNSRARAVYEANLPDTFRRPQTDCSLESFIRAKYEHKKYIAREWVPPTMPKVNWEKELDEEAEKQRRRKKESIKTNVNQNPLPPVKKPEVMPQLPKPGSSISPKAASKSNSSTATLDLLGLDSPSAQSTNSNNSGDDIFSSFLSATPATSSLTSESVVNGTTSSSNTNNNNNNNNNNNNNSNSNSNSAESTLSNNEASKADEESFFNQPAPSQEEKSKMTKDSILALYGNQTQHQQQQQQQQQQQPVYGLFAQQFPQSFSGVGVFGQQANFISQPSQPQQPQQQNNLVMGPMIQHNSVPPQHGIAISNHHINLSTNPMGLVAANNQLGGLQMASINQIASVPNPAMLMQAQVGDNNLPVMTSQMVQIAPTNIMSNNGWSNMLTTQNIQPAPGSNPFFNLASQTATNNTFSSQLSQQMSQMSLGGLVGKPAPATLPGQTLSTNLWQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HQU2</accession>
    <name>A0A8J2HQU2_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="22">E3 ubiquitin-protein ligase RNF144B</fullName>
            <ecNumber evidence="5">2.3.2.31</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="23">RING finger protein 144B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="28" type="ORF">HICCMSTLAB_LOCUS12638</name>
    </gene>
    <organism evidence="28 29">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="28" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="20">E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes UBE2L3 and UBE2L6 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates such as LCMT2, thereby promoting their degradation. Induces apoptosis via a p53/TP53-dependent but caspase-independent mechanism. Plays a crucial role in maintaining the genomic stability by controlling the degradation of multiple proteins involved in mitotic progression and DNA damage. Regulates epithelial homeostasis by mediating degradation of CDKN1A and isoform 2 of TP63. Plays a regulatory role in innate immunity by negatively regulating IRF3 activation and IFN-beta production. Mechanistically, inhibits TBK1 phosphorylation and 'Lys-63'-linked polyubiquitination independently of its E3 ligase activity. Alternatively, promotes 'Lys-27' and 'Lys-33'-linked ubiquitination of IFIH1/MDA5, promoting selective autophagic degradation of IFIH1/MDA5 to inhibit antiviral response.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.31"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subunit">
        <text evidence="21">Interacts with UBE2L3, UBE2L6 and LCMT2, as well as with BAX. Interacts with TBK1; this interaction inhibits TBK1 phosphorylation and 'Lys-63'-linked polyubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="19">Belongs to the RBR family. RNF144 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="28">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.31" evidence="5"/>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5107216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HQU2"/>
    <dbReference type="OrthoDB" id="10009520at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16632">
        <property type="entry name" value="mRING-HC-C4C4_RBR_RNF144"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20352">
        <property type="entry name" value="Rcat_RBR_RNF144"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1750:FF:000010">
        <property type="entry name" value="RBR-type E3 ubiquitin transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000051">
        <property type="entry name" value="RBR-type E3 ubiquitin transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031127">
        <property type="entry name" value="E3_UB_ligase_RBR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002867">
        <property type="entry name" value="IBR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044066">
        <property type="entry name" value="TRIAD_supradom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11685">
        <property type="entry name" value="RBR FAMILY RING FINGER AND IBR DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01485">
        <property type="entry name" value="IBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22191">
        <property type="entry name" value="IBR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00647">
        <property type="entry name" value="IBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51873">
        <property type="entry name" value="TRIAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="24" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="18 26" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="29" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 26" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="16 26" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="15" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="13" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="14" id="KW-0862">Zinc</keyword>
    <keyword evidence="12" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="26">
        <location>
            <begin position="471"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="27">
        <location>
            <begin position="249"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="25">
        <location>
            <begin position="20"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="25">
        <location>
            <begin position="515"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="24">
        <location>
            <begin position="219"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="25">
        <location>
            <begin position="20"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00038342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00060040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00061765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00069720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00078867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="27">
        <source>
            <dbReference type="PROSITE" id="PS51873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="EMBL" id="CAG5107216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="534" mass="57513" checksum="3628286681EB30A7" modified="2022-05-25" version="1">MPSLQTLVVRRAPLMDMGTATSSVTSVNPASSKNGTIHKKLDNNKTSNKLSNVGLKLPLVKQEHTGTGIGTGNSGNNFLLTERTIIGKGGLSNIGLSSSLIATGGCDNGNGVNSSNGVDVPLLGRPESSSSLEARASMGHGADVAVGGIQGGSWANLSPGSNLRKCKTAVGLSTLHLENRPINKSRVCSRCSSLLSLASSSRYSLAAGNFVPSTTTNQLNQQQTQQQQQQQQQQQQQQQQQQQQQQTSSQFLCKLCLVDVTVSKIFRIEGCGCFYCKDCMKAYVEFEIEEGAYEISCPDAQCDWSSILTLKEISTLVSSELMEKHQKFRLNRDVSMDKDRAWCPRAGCETICSINSPGSNGMSPGPVHCPNCSTDFCSVCRESWHNGPCPNLPLGIPFDNDHIKCCPMCSVPIEKDEGCAQMMCKRCQHVFCWYCLASLDDDFLLRHYDKGPCKNKLGHSRASVIWHRTQVIGIFAGFGLLLLVASPLLLLAAPCIVCCKCRVCGSSRLEHDNNNGNGSNGGGTSTGNHDDSST</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HQW1</accession>
    <name>A0A8J2HQW1_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Neutral ceramidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HICCMSTLAB_LOCUS13930</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="2">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5109294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HQW1"/>
    <dbReference type="OrthoDB" id="191371at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017040">
        <property type="term" value="F:N-acylsphingosine amidohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046514">
        <property type="term" value="P:ceramide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042759">
        <property type="term" value="P:long-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046512">
        <property type="term" value="P:sphingosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006823">
        <property type="entry name" value="Ceramidase_alk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031329">
        <property type="entry name" value="NEUT/ALK_ceramidase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12670">
        <property type="entry name" value="CERAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12670:SF1">
        <property type="entry name" value="NEUTRAL CERAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04734">
        <property type="entry name" value="Ceramidase_alk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Neutral/alkaline non-lysosomal ceramidase N-terminal" evidence="3">
        <location>
            <begin position="1"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="88"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="127"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00019235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR606823-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG5109294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="142" mass="15523" checksum="1846F655118A2C91" modified="2022-05-25" version="1">MGYSFAAGTTDGPGSFSFAQGTTTTNPMWNAVRNFVAVPTEEDIKCHGAKPILLATGRMRLPYQWQPQTVSTHLAMIGDLVIVGVPGEFTTMSGKRMRETIASTAEEITKARPTVVIAGLCNTYSDYIATPEEYEYNPDYTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HQW2</accession>
    <name>A0A8J2HQW2_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">HICCMSTLAB_LOCUS12683</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. GCN2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5107306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6778822at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004694">
        <property type="term" value="F:eukaryotic translation initiation factor 2alpha kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990625">
        <property type="term" value="P:negative regulation of cytoplasmic translational initiation in response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009893">
        <property type="term" value="P:positive regulation of metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd23823">
        <property type="entry name" value="RWD_GCN2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd14046">
        <property type="entry name" value="STKc_EIF2AK4_GCN2_rpt2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000050">
        <property type="entry name" value="eIF-2-alpha kinase GCN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000057">
        <property type="entry name" value="eukaryotic translation initiation factor 2-alpha kinase 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050339">
        <property type="entry name" value="CC_SR_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041715">
        <property type="entry name" value="HisRS-like_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006575">
        <property type="entry name" value="RWD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11042:SF136">
        <property type="entry name" value="EIF-2-ALPHA KINASE GCN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11042">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2-ALPHA KINASE EIF2-ALPHA KINASE -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05773">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13393">
        <property type="entry name" value="tRNA-synt_His"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00591">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50908">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 15" id="KW-0418">Kinase</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1427"/>
            <end position="1446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1453"/>
            <end position="1472"/>
        </location>
    </feature>
    <feature type="domain" description="RWD" evidence="14">
        <location>
            <begin position="12"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="329"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="domain" description="RWD" evidence="14">
        <location>
            <begin position="1495"/>
            <end position="1609"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="1704"/>
            <end position="1937"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="1984"/>
            <end position="2315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="142"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="189"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="303"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="409"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1650"/>
            <end position="1671"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="190"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="216"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="303"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="418"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="453"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="470"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="493"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1650"/>
            <end position="1661"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="358"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="2013"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CAG5107306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="2964" mass="342275" checksum="0B6F89EEA592F162" modified="2022-05-25" version="1">MSQESCQDRQNNEFEVLKSIFGDDLEDMRNNKNKRKWQPLNIKVTLTPSQGMSGPVQVYAQIDLHVMCGESYPEDAPHIKLKNSLGLSNQQIAVLYSELESLADKLKGEVVIFELTQHVQKFLYEHNKPSYNSFYEEMVSRRQEQMQSEMHKKQLKESQERQVLQDEIHRRQEALKAELRDRKRMARLSLESNETSQSIPSSPHERVRTYSRRRCLSSSESPDSPLSEHRATKILHFISNRGERQIQLGKCLGKSVKGSVVYDGVDIKAVEHLAVTEWTLRWSAKQLQQHNFIRIPLISELSSPKHSDKQENNLETEEPTSDSRMKNEFKILESLGEGAFGDVWKVRNKLDGRVYAIKRIALDPKSKQSNKKMIREVKLLSRLNHENVVRYYNSWIENVNISNVKRYSSSLSDQMSVNEEKTEKIKNHDLKNFESRSVTISEEDSSSSSSDDSSSEEESEDEEGFFHSPQKSEESSDGIEFKVDSESQISKAESFETSEKITSEENSSVEHKTKFMYIQMEFCEKSTLRTAIDNNLYEDKDRLWRLFREMVEGIAYIHQQGMIHRDLKPVNIFLDSNDHVKIGDFGLATTNILCSVVQTIDNERKVEVDNKNDIILDEPRSMTGQVGTALYVAPELRNEVAKARYNQKVDIYSLGIILFEMCCKPPDTKMERVTILQKVRSKEIILPPDMTETEMPHQTHLLRWLLNHDPNQRPTAQELLTSEYLPPPLLEEAELQEMVQHTLSNSQSKAYKYLISCCFTQKVSQAEDINYDMTVLNRPANSSSSVVNRLLHDHVKSIIVEVFQRHGGVNLATPLLMPKSGHLYDHTETCVKLMTHSGSIVTIPHDLRAPFARYVAWNDILHLRRYVIERVFREEKVHGFHPKELYECAFDIISSTVNLMAEAELIRIVWEIFNDFSDMRQFDFTVRLNHTSLFEAVLIYCGIGPEKFQEIFFINDNAQDGKSSKFSAQSYLENLGLSDQVIETLINLSNTENNALKIANFLKKLTLRMGDAAILAKNALREIETVTAHIGALGVKWPIVIAPLLTHNMKQHRGIIFQITCDFKRRRRRVGQEIIAAGGRYDKMLQVFERISERSGLTSKENRHHGVGISISLDRLVSVIQELLLEDSNIEMNVKKFGINIAVGLINKKNKREHELADLLRQLWSLDLRVTKLDFNKTEEMLDYCRKNLIPCVIILDDEKENLSVHFWERKMKRFKEQKMSTTEFTEYLRKPNTTSQQTDPPPVLHRSESKINNMESTTNPHNTSINVNINFVLLEKDKLSSSGRKSYRNSMLAQLSSSLHRISYKDPIEVFAVFLEMPVIKTIFGLLELDEKEQDFQRSVQFVIEEHPYHKKSIKQVCDEMRKIRNEKQRPVLVLYSLTDGRFIRFSFILGWAVIDYDHLVLNYTEYGNYTEYQYESRLLDDPELLYFYVPACFLMLVLSSLMIFGTLKDKYKFILPHFYAHIFLVASSMMNQTYNIAVEFAYYQNIEYGFLLLAKGILSGVFGDNLQDLRNNKNKRKWQPLNVNITLTPSQGMPGSAQENIQIDLQITCGETYPENAPHLQLKNSVSLSDDQVSVLYSEIKDLAEKLRGEVMILELSQHVQKFLHTHKKQGCNNSCEKIQGEMPEKQLKEKQEPQVLLKRMARLSLESNELPSSNPSSPQERVRSYSRRRCLSTSESSESPLCEFTQTKVLNFLSNKGERQVHLVKCLGHSAKGSIIYAGVDIITVEHLAVTEWLLRYASPGEKKSESEVLNLQQLMKQVVIIEQELHHLQKLDHPNLAHYLNIKYLQNKDSIVVYILQEFVVGTTCTFFQKENISVNIDLLRYIATGVLAALEYLHENNIAHKDLTDSNIYRSSCLGKANNNFTLIKEQGEKELDIYRFGTLLLTLLKVKIVSDNEADWGLSLPSILRDFLSKCLNRDEKLRWSAKQLQQHNFIRTPIVNELSLPKHCNNEDDNSESEEPTFDLRSYLPSLDSNSRFKNEFEILKLLGEGAFGDVWKVRNKLDGRFYAIKRIALNPKINELNKKMIREVKLLSRLNHENVVRYYNSWIENVKVSNVKRSSSSSSEMTSLNKDKRDDIEKLKAERIIKLLSPVNDVEWTVSFENPSNVVSDEDYSSSSFSDEDSSEDENRLWRLFREMVEGIAYIHQQGMIHRDLKPVNIFLDSNDHVKIGDFGLATTNILCSVVQTIDNERKVEVDNKNDIILDEPRSMTGQVGTALYVAPELRNEVAKARYNQKVDIYSLGIILFEMSYRPPDTKMERVTILQKVRSKEIILPPDMTETEMPHQTHLLRWLLNHDPSQRPTAQELLSSEYLPPPLLVEAELHEMVQHTLSNSQSKAYKFLIASCFDQQVTPAEDITYDMNVPSRSANNEVSVVNELLHEHVKSEAINVFQRHGGVYLATPLLMPKSSHLYDHTETCVKLMTHSGSIVTIPHDLRAPFVRYVALNNIEHFRRYAIERVFREKKVHGFHPRELYECAFDIISSDVDLMAEAELIRIVWEIIDKFSELHQREFTVHFNHTSLLDAVLMYCGIGPEKFQDIYSILSDARDGKCSKLQVQTHFISLCLTDQAMETLLNLFDTENNVSKVASILRSITKRKSDAAVLAKSALKEIETVTTHVKALGVQWPVIIVPLLAHNMKQQSGIIFQISCDLKRKRRCQEVIAAGGRYDEMIQSFHQISKSSDLIVKKSHHGVGLSISLEKLVCAIQDVILEDTNNELSINRFRIDVAVGFIDSKPEREHELADLLRELWSLGLRVTKLDFQVQEEILDYCRKNLIPHVIILHGGIGNLVLYSWEYDKFREQKICITEITEHLQRPIDTLPVLKSKNRTTDSTYSSSNYLNINFNFIPTERDKLSDNYKINYKNTMLAQMSSALQRISCKVSIEVFAIFLEMSIMRTMVKLLEIDEKEQDFQKSVQFVIEEHPLTKKYIEQICDKIWEVRNEKQQRPVLVFYSLTENNYVIFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HRG6</accession>
    <name>A0A8J2HRG6_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS13578</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5108942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HRG6"/>
    <dbReference type="OrthoDB" id="5960270at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021454">
        <property type="entry name" value="DUF3105"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34179">
        <property type="entry name" value="TUMOR PROTEIN P53-INDUCIBLE PROTEIN 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34179:SF1">
        <property type="entry name" value="TUMOR PROTEIN P53-INDUCIBLE PROTEIN 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11303">
        <property type="entry name" value="DUF3105"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035225722" evidence="1">
        <location>
            <begin position="18"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5108942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="343" mass="39582" checksum="EB341AE2A8A9FEF2" modified="2022-05-25" version="1">MISQFIFILLFYNSVNVNFFVFGYNSDYHDIVEKQSNNIQDILGLRNHVLEQDNINTLPYYSNDKTEYQKNNIRNVDNPLKYELDNWTGRWMPDKDSPNTDKNTNIKNLDVPMKSELDNWTGRWMPDKDSGVVPIPVADSDNNHLSDDNTQMGKIPQCDDGKNLLEVDWDGSPINYTCFSRKIIPSNEIHPELYCEKIPKLYSARHACMNESIDYDDKIPIGTHRPVWPVYGEYKFVPKQRWIHSLEHGAIVMLYHPCANKNQVNLLRKLPFALVTWGCRLTMSTISPYIVRNFILTKALHGAETTPKDGEFNEGLMQKAKTVSDENDSKLCPLDSSVVMIII</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HRR1</accession>
    <name>A0A8J2HRR1_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Similar to Mad: Protein mothers against dpp (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS13214</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5108392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HRR1"/>
    <dbReference type="OrthoDB" id="5794312at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.520.10">
        <property type="entry name" value="SMAD MH1 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036578">
        <property type="entry name" value="SMAD_MH1_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5108392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="71" mass="7801" checksum="2AE3BD48BEE84EF0" modified="2022-05-25" version="1">MDDDEGTSSSGPVSSLNSLFSFTSPAVKKLLGWKQGDEEEKWAEKAVDSASQRLSQPIFLPRRPASNLEVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HRS1</accession>
    <name>A0A8J2HRS1_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similar to EAG_11010: Short neuropeptide F (Camponotus floridanus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS12061</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5106028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HRS1"/>
    <dbReference type="OrthoDB" id="6364308at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007218">
        <property type="term" value="P:neuropeptide signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0527">Neuropeptide</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="107"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5106028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="135" mass="15786" checksum="5D34E3415D6F7D48" modified="2022-05-25" version="1">MYNNKLIKSLKQKFCCGFRFRYNKGSIMRSYRCAIVLFFILGAALAAESYLDYGEENADRNIENLREFYRYLLRRNSLEGLRSSMSLDSPYEHLMIRKSQRSPSLRLRFGRSDPMMPKGNLLTRSASNPASFEDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HSI3</accession>
    <name>A0A8J2HSI3_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS13884</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5109248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HSI3"/>
    <dbReference type="OrthoDB" id="7697116at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="entry name" value="Intergrase catalytic core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="DNA breaking-rejoining enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5109248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="98" mass="11210" checksum="7E70DAD12402F7A1" modified="2022-05-25" version="1">MDRFFLQLQKGKCVRQVIGKNIFGQIPKNIAKHLNLPEPKKFTGHITCSFRRTSTTLLADSGALMTTIKQHASWRSDAIASRYNENSIQNKKKFMIKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HSS7</accession>
    <name>A0A8J2HSS7_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Kazal</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS12665</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5107270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HSS7"/>
    <dbReference type="OrthoDB" id="8187079at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030414">
        <property type="term" value="F:peptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.75.10">
        <property type="entry name" value="Elafin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036645">
        <property type="entry name" value="Elafin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008197">
        <property type="entry name" value="WAP_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00095">
        <property type="entry name" value="WAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00217">
        <property type="entry name" value="WAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57256">
        <property type="entry name" value="Elafin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51390">
        <property type="entry name" value="WAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WAP" evidence="1">
        <location>
            <begin position="11"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5107270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="102" mass="11045" checksum="C3AA8CC357619204" modified="2022-05-25" version="1">MISIAVINAQGSYKSGYCPLQNTVTRCMPRCHSDYECSFNEKCCPNKCGSMSCVSPSAVATGYNGGYKGSGDNGVSCGGTTCNKYQKCEFNRSTKRYECVRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HSW4</accession>
    <name>A0A8J2HSW4_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS13942</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5109306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HSW4"/>
    <dbReference type="OrthoDB" id="6922936at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="28"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="83"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5109306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="115" mass="13281" checksum="43B9AC24F5DDC3CD" modified="2022-05-25" version="1">MCDNDNSEGPSDQPCAKKVKLHYGILPSHHSQQSSQGSQNIIVETGRYPDQVYNSKRKRQKQYRERNREKLKHREAERRKRIQSSQSIIGPSTSSNSNIMEVNNEKPLPFSVRNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MAN1</accession>
    <name>A0A8J2MAN1_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS2908</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001117">
        <property type="protein sequence ID" value="CAG5079046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MAN1"/>
    <dbReference type="OrthoDB" id="10466779at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="179"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="608"/>
            <end position="634"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5079046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="789" mass="90601" checksum="C68DD1CDB6294419" modified="2022-05-25" version="1">MALKILLQDDDKEYLEMVDVDETGKIILNKIKQRVDKEHKKIKRIKTSRGVNPKTNDEEIISAKSIFDVDPEKTSTSSGKRRAIGFIMTSSDEDNEPGKIRVVPRKKNKNQTQSDYDEFSAMGDVSENEEIITNVKPSFIEETGRTQIGRNVDRPMNLDQNRFSKSYFGANFRKVSSLTGKRRASSPIISSSDDNSDSDGVRALPKEDSKYWMRDNHEKSSERIDVNKNEKLSYKIRPNLDEENERLDANRNVRQPINREEYQSSRSYFKTNFGKISSLTVQSKFRDEIVKSSDEENDSDEAIVDQDYDKALKKLNVNEDKKMASSNVTSNVETGKEKFKSKRKIHPLINDEETALSRSSFTANYNKLSSLTVKQKASHPIFTSSDEDKDSNETEVIPKKNVEKSTKIVDVHFERPSLKIKNITARKDRQYDSSVNNEKILFSRPKFNTDLQISIPSTSQNPKTNKTDDLKKLTTLSTKMNTNRLLDYATDEDTEHDDIQIKNSKVFVKENRNIEPILQKNKLQTRLVQYSISSEDSSDNDNDTQDKNLSKIGFDIKEVGIIDKTNNTNNELTKESNNDNNLKDKKQKLQEKNLSIHSLNSFENKINSSLKASRNRKQKITPTNGKSSKIVDDSNDDEVSMEDLKLFKQFLQFKRSNERQLVKSSGHTKQKKIVNTKKEVELIEGSNIMVSEYRLLMITKCNTKKAGQMIRDLFRLVLGEEKLSRMVPLKQKEGRELIPEDISKAIFQYVNANVSKGHEVNVDEFQNIVGSMCCTIRGKFKTKEKEKKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MDG2</accession>
    <name>A0A8J2MDG2_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS3760</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5083192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MDG2"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5083192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="494" mass="58002" checksum="17C6762773FD2395" modified="2022-05-25" version="1">MNFLLIFSTITPIFSGNFEEEYINNLFVRKSFADNLPSNVLPMAIAENLRETFFHLISLPRKNITDEVNQRRLVEAFGYIEDAFKYIETFENKDKHMSNEEILKPLKMQACQFSTVEFLESCDKIEKIWKNVFARYIKIYSEYKFEELGNLHLAVDVKKTFQKSLEALQGYAMLLQNKIAVTRNITENIFRSYFKCFLSANEDDNCNLTPLSNQLFRLYKRGLFAAMRAYTIKIVYLEFSHIILKKYDTFLNAEKYNYNEYSNLLHNLVMSLTGEIYLITPENTSYKNCDPPNWIEGENYIRIKNYVSQKLDHNLKISKFNQINRPESECSDYSILTDSNRNLFISKRCPEIFELNSYRIVDCANTGQQEMTNNNLANWTLECSNDNYGIDLNFHCSCDKMSDQDLSLRTVSLREEGFNLQVVTGIRFAVKNNGLMIQIQEGQLINETIDLKTVKWQTDEERILEKGIESVRLNYYVKSFNLDDIQEISDKFTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MDS1</accession>
    <name>A0A8J2MDS1_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS3957</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5083878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MDS1"/>
    <dbReference type="OrthoDB" id="7554309at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5083878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="751" mass="86750" checksum="1E400B8197237AEF" modified="2022-05-25" version="1">MEALLQSWDLSELYSTFCGKLISHQERINLKDESQPNTCWQLMPVTSDCSKISDKFSDIDIDSLPVDFVNTNVFDKVITENNIRLPQKKKKKKESKFCYFNLKELLSEHPVGKELLLISNQKKIQLEASWISTLCEIIVYDCLKKNITLVNEDHEELASKIVELFPAECTQTFYVPPVKKKDSLSNMSLISKGKLVDKYRNTLVIIRNIKKFSECFNNTGESESISLNTGDNSALESKQWLMHHREELDVLLHWKSSFELRRSEVDSNKYSSVTDIFNDWPILKESICSVLINTDYDNVYKNKVINVNESWGNIFHLLKNISVDKIAKDYLPKLRLLDMSEKNVSPLSKYIIQLEIFIHLLSAVKPRRKGKNSKKETHTRNNNQEDALSAAIESVYMHVKVPGDVDTACEKKICQKAKTKSTIQPFLIVVGPNELDLQKVYVQVDNFRFETSTFIEGFDLLFKFYLMFKIAYPVESQNFCKFYSNTTVTEKLAQETIQEFQKLMSEISVTTLKKLKERIPIEYHDFMEDCFKLDVFENFDSKWRCMQQLKNSEFYFAPRQFKIGEIGDDKNINNSIKWTKKACYGQIISLRAVLKKFLELPNVFKTIMNFMQTESARIESQGDIYSSLFQGTLWKNISGAFQEKIVIPLYLYYDDFEIDNPLSTSAGIYKVGGLYCSIAALPPQFASTTANVFLPQLIHNSDYKEFGAERCFAEIKDELNYLTQFGITISINGESHRIYFVLIGILGDNLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MGL7</accession>
    <name>A0A8J2MGL7_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Similar to Gcn1: eIF-2-alpha kinase activator GCN1 (Mus musculus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HICCMSTLAB_LOCUS5198</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GCN1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5089337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5148094at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019887">
        <property type="term" value="F:protein kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034198">
        <property type="term" value="P:cellular response to amino acid starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000090">
        <property type="entry name" value="eIF-2-alpha kinase activator GCN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000096">
        <property type="entry name" value="eIF-2-alpha kinase activator gcn1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000162">
        <property type="entry name" value="GCN1, eIF2 alpha kinase activator homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056810">
        <property type="entry name" value="GNC1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000357">
        <property type="entry name" value="HEAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057546">
        <property type="entry name" value="HEAT_GCN1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021133">
        <property type="entry name" value="HEAT_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034085">
        <property type="entry name" value="TOG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23346:SF7">
        <property type="entry name" value="STALLED RIBOSOME SENSOR GCN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23346">
        <property type="entry name" value="TRANSLATIONAL ACTIVATOR GCN1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24993">
        <property type="entry name" value="GNC1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02985">
        <property type="entry name" value="HEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24984">
        <property type="entry name" value="HEAT_EF3_GNC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24987">
        <property type="entry name" value="HEAT_EF3_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13513">
        <property type="entry name" value="HEAT_EZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23271">
        <property type="entry name" value="HEAT_GCN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25801">
        <property type="entry name" value="HEAT_GCN1_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01349">
        <property type="entry name" value="TOG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50077">
        <property type="entry name" value="HEAT_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TOG" evidence="5">
        <location>
            <begin position="1340"/>
            <end position="1573"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="4">
        <location>
            <begin position="1514"/>
            <end position="1551"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="4">
        <location>
            <begin position="1633"/>
            <end position="1671"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="4">
        <location>
            <begin position="1981"/>
            <end position="2018"/>
        </location>
    </feature>
    <feature type="domain" description="TOG" evidence="5">
        <location>
            <begin position="2237"/>
            <end position="2465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAG5089337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="2614" mass="289505" checksum="EE2D6E52333E5BCD" modified="2022-05-25" version="1">MTMKLVTFAMCPGLSENMADAELLKALKDLPNRVQTSSLKERYEVIHNVIDVLSNPGINEKIVNGICKVVASTLQRYKDNKSQYYVRNLIAELLKHQNIHGVKYMTAVITEQATWHQNVVPTFSTSLTAYQVLKWTSLVITAIPEDLSTHTESQKLIEAQASLSAAAVASANASLSKKVYSLLTQLWNSTKNSEKIYITNLSKMEPSNGVIVLSSLLIKHLVSQKKDELIDPFKNSILEGFIKLAISCKKKPDLFTVDSSTPFLRRLTHEDFKNQLLPALQKAMLRNPEIIIDSVGHILTGLSLDLSRYCEDISKGLFANLHSKEDSVRDSAADACRRLALQCSDTEALEKLLSLLFAIFHGSEGKLTVATHKISVLTGAGNLSFNAAGSNVQKVAEAACGHFIKVLDTEVHEKTLIHALEMMSLWCQKFSAEVPKNIIETFKKAMNAKTSTTGLRTAYIKLLFTLPINSHADTVTPILTQAISRASQQSTQASAVTEGLVASYLLLKLITGQVDNNKQSVLWSAIDEQVFFSDKFLSTCSDDNLFHLMQLCEVLVTDFTDRLNEKALNGVHRALVVCVVHNSATRRRCAAILKKMLTGLSTYEPCRALIKEFNSFVEDNKENNDINGRCLADGLLAICSSSFLFEEPVYQLVFDALIPAHHPIVIKAVPKLWVKICSNSGLSPQTFFTDYFVKIQETFAYSYQPSAAYENAVATIVSFSPDVLLEEMMNEVTDYLSDEEILKVTKDEYFIYLTPEGELYDKSVVPGNDDDDILNSMNMKRESKAYSFKEQLEEQQLRRELYEKRKREGKIKEQKLTPKQEEVLRAQTAKENAIRNRLKGLFEKITRIVSMINALSRGNPKELALFFCKLIPALLKNLSSPLAAPTVAQVYLELQKIVELVSPKNSVLKELVGHVTLRQQQPQCDLDPAWEEEELEKAVQRTLAAVHGCTVKQKVLFNAPGFCYCFPFIGHTLLSWKDEAMITQGLQVIQEHAKQRGDLDSKDPRHPKFLPRKEMLDLLIELMSSTTGRVQSHAVATFLDVAYSGDGSPGTAETSSEEINSLIGALENPLAAVRDAALRALMIVHDNFPTEDSDYEQYWRLTRRIWIARFDIADENKVLASEIWDKAEFTANGEILCESLIQDVAHPVEAVQQSTAHALAHLLTDNTHLVPEILESLLKLYREKLAMIPPKMNDFGRVVEQPVDIWGPRRGVALALAQLAPLLTADTINLLIQFFVSTGLGDRNPSVRQEMLTAALAAVDHHGKDNITSLLPVFEDFMDKAPKIGSFDAIKQSVVILMGSLARHLDKDDPRIKPIVMRLIKALSTPSQQVQEAVANCLPHLVPSIKEDAPRIVDNLMDQLLKSDKYGERKGAAYGLAGIIKGMGILALKQLDIMTKLTNAIQDKKNYRHREGALFAFEMLCTMLGRLFEPYIVHVLPHLLLCFGDASQYVRTATDDTARVVMSKLSAHGVKLVLPSLLAALEEDSWRTKTGSVELLGAMAYCAPKQLSSCLPSIVPKLIEVLSDSHTKVQEAGAEALKVIGSVIRNPEIQAIVPVLLKALQDPSRKTAMCLQTLLDTQFVHFIDAPSLALIMPVVQRAFMDRSTETRKMAAQIIGNMYSLTDQKDLTPYLPTIIPGLKMSLLDPVPEVRSVSARALGAMVRGMGESSFEDLLPWLMQTLTSETSSVDRSGAAQGLSEVVRGLGVEKLHKLMPEIISTAERTDIAPHVKDGYIMMFIYMPNAFTTEFTPYIGQIINPILKALADENEYVRETALRAGQRIVTLYADSAIMLLLPELERGLFDDNWRIRYSSVQLLGDLLYRISGVSGKMSTETASEDDNFGTEQSHHAIINALGAERRNRVLAGLYMGRSDVALMVRQAALHVWKVVVTNTPRTLREILPTLFSLLLGCLASTSYDKRQVAARTLGDLVRKLGERVLPEIIPILERGLLSDQPDQRQGVCIGLSEIMASTSKDMVLTFVNSLVPTVRKALSDPLPEVRQAAAKTFDSLHSTVGARALDDILPLMLVQLNSPDPQEAENTLDGLRQVMAIKSRVVLPYLVPQLTSAPVNTKALSILASVAGEALTRYLHKILPALLMALSSAQGSENEAQELEYCQAVVLSVTDEVGVRTVMDQLMDATKAEDPSRRRGAATLLCAFCRDTRADYSQYVPQLLRGLIHLFTDDDKEVLQKSWEALSAVTKTLESDQQIAHLGDIRQAVRFAASDLKGQELLPGFCLPKGITPILPIFREAILNGLPEAKEQAAQGLGEVIKLTSAAALQPSVVHITGPLIRILGDRFNWSVKAAVLETLAILLGKVGVMLKQFLPQLQTTFLKALNDSNRQVRLKAAYALSNLIVIHTRADPLFAELHSAIKNSDDPAIRETMLQALRGVITPAGDKMTDVMRKQVFVTLSSMLGHPEDATRNAAAGCYGALMRWLSPEQFASACNEHLLSHDVNADWQLRHGRSTALFVILKESPATVYGSKEQDRVCKIILSYLQADRSMNNNSNEVKQLLARVCIHLARNIPPEKMSGDLLKSLLPMLVNGTKEKNGYVKANSELALIAVLRLKTGDEEHQRCIALLDPGARESLSDVVSKVLRKVLSQPEGKIEELDDTLLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MH30</accession>
    <name>A0A8J2MH30_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="14 17">Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase</fullName>
            <shortName evidence="17">GNT-I</shortName>
            <shortName evidence="17">GlcNAc-T I</shortName>
            <ecNumber evidence="14 17">2.4.1.101</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15 17">N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase I</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">HICCMSTLAB_LOCUS5926</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="13 17">Initiates complex N-linked carbohydrate formation. Essential for the conversion of high-mannose to hybrid and complex N-glycans.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16 17">
            <text>N(4)-(alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 5A1,2) + UDP-N-acetyl-alpha-D-glucosamine = N(4)-{beta-D-GlcNAc-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11456"/>
            <dbReference type="Rhea" id="RHEA-COMP:14367"/>
            <dbReference type="Rhea" id="RHEA-COMP:14368"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:59087"/>
            <dbReference type="ChEBI" id="CHEBI:60625"/>
            <dbReference type="EC" id="2.4.1.101"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="17">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="17">The cofactor is mostly bound to the substrate.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 17">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 17">Golgi apparatus membrane</location>
            <topology evidence="1 17">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 17">Belongs to the glycosyltransferase 13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.101" evidence="14 17"/>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5092120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MH30"/>
    <dbReference type="OrthoDB" id="440755at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003827">
        <property type="term" value="F:alpha-1,3-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000055">
        <property type="entry name" value="Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.20">
        <property type="entry name" value="N-Acetylglucosaminyltransferase I, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004139">
        <property type="entry name" value="Glyco_trans_13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052261">
        <property type="entry name" value="Glycosyltransferase_13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10468:SF0">
        <property type="entry name" value="ALPHA-1,3-MANNOSYL-GLYCOPROTEIN 2-BETA-N-ACETYLGLUCOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10468">
        <property type="entry name" value="PROTEIN O-LINKED-MANNOSE BETA-1,2-N-ACETYLGLUCOSAMINYLTRANSFERASE 1/ALPHA-1,3-MANNOSYL-GLYCOPROTEIN 2-BETA-N-ACETYLGLUCOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03071">
        <property type="entry name" value="GNT-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 17" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="10 17" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="12 17" id="KW-0464">Manganese</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 17" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00037706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00038949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00041712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00049421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU368119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="CAG5092120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="447" mass="51903" checksum="17C009226EC7438F" modified="2022-05-25" version="1">MRKKSISLLLLSLLVWGIITYFLFLTRTTDNRDKNVLSNQINSLKAQVERRIADNQILLKRLIKLQQQKLAEQIKTPSPLIEEILNATYPVASTVKLKTEEEIISERLQALSSKKLVNDSPIIAVLVISCNRITVQRCLDQLIKLRTNADQFPIIVSQDCEHKQTADIIKSYGDQVVHIQQPDQSDIDIPPREKKFKGYFKIARHYGWALNKVFFEFGFDTTIIVEDDLDVAPDFYEYFLGTYPLLVTDKSLWCVSAWNDNGKSGLVDENAPHLLYRTDFFPGLGWMLTKDLWQELSVKWPKAYWDDWIRQPEQRKNRACIRPELSRTRTFGKVGVSNGLFYEKHLKYIKLNDQSVPFTKMNLSYLLKDNYDINFVNDVYHSTVVSYSELKSGNIITSGSVRIPYHSRQAFKNTAKMLGLMDDFRIEDIYCVMLQTSDVRAVYRLKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MHX4</accession>
    <name>A0A8J2MHX4_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Poly [ADP-ribose] polymerase</fullName>
            <shortName evidence="5">PARP</shortName>
            <ecNumber evidence="5">2.4.2.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HICCMSTLAB_LOCUS4112</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>NAD(+) + (ADP-D-ribosyl)n-acceptor = nicotinamide + (ADP-D-ribosyl)n+1-acceptor + H(+).</text>
            <dbReference type="EC" id="2.4.2.30"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.-" evidence="5"/>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5084469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MHX4"/>
    <dbReference type="OrthoDB" id="429950at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003950">
        <property type="term" value="F:NAD+ poly-ADP-ribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990404">
        <property type="term" value="F:NAD+-protein mono-ADP-ribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006302">
        <property type="term" value="P:double-strand break repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070212">
        <property type="term" value="P:protein poly-ADP-ribosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.228.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050800">
        <property type="entry name" value="ARTD/PARP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012317">
        <property type="entry name" value="Poly(ADP-ribose)pol_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10459">
        <property type="entry name" value="DNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10459:SF60">
        <property type="entry name" value="POLY [ADP-RIBOSE] POLYMERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00644">
        <property type="entry name" value="PARP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56399">
        <property type="entry name" value="ADP-ribosylation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51059">
        <property type="entry name" value="PARP_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3 5" id="KW-0520">NAD</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PARP catalytic" evidence="6">
        <location>
            <begin position="172"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00033987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAG5084469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="392" mass="45746" checksum="1C45D02A842E04F9" modified="2022-05-25" version="1">MEMNAGNARIPRRVYENGNQQYSMIDFAKSKYDRSLVHKYQVEIWHGKQENKYILYRSWGTSKAHIKYEKKKHWSLETCLVKFKLFVSAKIKKLIFATLDANYRPCQVPLPIQCLLKDILDVNIIQKISKIYDIDEELSVPEDLKINLVMEFMNEDVEFQLINKSDRKLFRNPMNVYYKNLHTTIEILDKKSPRFKMIEKYVKNTHAITHDHYSIKIDNVFLVQPHDIKKYKKNLRNKKLLWHGTIKTKISSILANGLQLPDPSERGLMFGPGIYFSNCVSNAANYCNTDAKVPNGVLLLCEVALGTMLEKFRAENDLVKLPDDKHSVFSRGVLTPEPTEVTIIPQNVEVPYGKLVTVDLARSAKLRHDEFIVYDPNQIKIRYMLTVHFEYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MIV0</accession>
    <name>A0A8J2MIV0_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Mitochondrial (Mus musculus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HICCMSTLAB_LOCUS7120</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5093794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MIV0"/>
    <dbReference type="OrthoDB" id="5859791at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990246">
        <property type="term" value="C:uniplex complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036444">
        <property type="term" value="P:calcium import into the mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051560">
        <property type="term" value="P:mitochondrial calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15900">
        <property type="entry name" value="EFh_MICU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039800">
        <property type="entry name" value="MICU1/2/3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12294">
        <property type="entry name" value="EF HAND DOMAIN FAMILY A1,A2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12294:SF13">
        <property type="entry name" value="MITOCHONDRIAL CALCIUM UPTAKE 3, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="EF-hand" evidence="10">
        <location>
            <begin position="241"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="72"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="73"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAG5093794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="301" mass="35135" checksum="57F40B8F84A4341D" modified="2022-05-25" version="1">MRKLFGSGIRNRQLHEATERVLQKLVTPSEEMTLATKTILRDNHDNNSSKSQSISSSSYMEKIFSYAWKGRHGGHDQNTNKDKVPGNDNFVGETPREDEGLQRRHAVDTTIMIHFFGKDGTKELKYDGFRQFMENLQHEVLEIEFQEFSKGSDTISALDFAKILLRYTDLDTDEYDKYLGRLLENPERHEDINFPEFRLFYQFLNSLDDFAIAMRMYTLADHPISKDEFHRAVRICTGTIIPMHMIETVFALFDTDGDGELSYKEFIAIMKDRLHRGFKTQPRGEGWEAFKYCLKQEMKAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MJI8</accession>
    <name>A0A8J2MJI8_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Cytochrome b5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">HICCMSTLAB_LOCUS2716</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Microsome membrane</location>
            <topology evidence="11">Single-pass membrane protein</topology>
            <orientation evidence="11">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12 14">Belongs to the cytochrome b5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001117">
        <property type="protein sequence ID" value="CAG5078357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MJI8"/>
    <dbReference type="OrthoDB" id="260091at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.120.10:FF:000002">
        <property type="entry name" value="Cytochrome b5 type B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018506">
        <property type="entry name" value="Cyt_B5_heme-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050668">
        <property type="entry name" value="Cytochrome_b5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19359">
        <property type="entry name" value="CYTOCHROME B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19359:SF150">
        <property type="entry name" value="CYTOCHROME B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00363">
        <property type="entry name" value="CYTOCHROMEB5"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00191">
        <property type="entry name" value="CYTOCHROME_B5_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0249">Electron transport</keyword>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3 14" id="KW-0349">Heme</keyword>
    <keyword evidence="9 14" id="KW-0408">Iron</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0492">Microsome</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="80"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="15">
        <location>
            <begin position="3"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00037877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00038168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00039806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU362121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CAG5078357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="101" mass="11533" checksum="DDEAECF576081C96" modified="2022-05-25" version="1">MSTNYFSREEVAKHNNSESIWIIIKSYVYDVTDYLNEHPGGAELIKECAGKDATSDFNNFGHSSDASNLMKLYKIGKIKVGIAYFIFYVVYNLQFTLSFLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MKH0</accession>
    <name>A0A8J2MKH0_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1 homolog</fullName>
            <ecNumber evidence="3">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">HICCMSTLAB_LOCUS5353</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="11">DNA helicase that possesses intrinsic ATP-dependent nucleosome-remodeling activity and is both required for DNA repair and heterochromatin organization. Promotes DNA end resection of double-strand breaks (DSBs) following DNA damage: probably acts by weakening histone DNA interactions in nucleosomes flanking DSBs.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF2/RAD54 helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="3"/>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5089726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MKH0"/>
    <dbReference type="OrthoDB" id="448448at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14279">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10810:FF:000014">
        <property type="entry name" value="SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10799">
        <property type="entry name" value="SNF2/RAD54 HELICASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="14">
        <location>
            <begin position="372"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="15">
        <location>
            <begin position="702"/>
            <end position="862"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="40"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="131"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="192"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="7"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="40"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="81"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="133"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="194"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="226"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00059294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00069890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CAG5089726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="905" mass="103712" checksum="CD25A0EA8F75CA6A" modified="2022-05-25" version="1">MFDSITNNNNNNSSSNNNNNQDAVSPTLANNLRRFRFQKKPLDKLKMSDEDSNLASPDIQVRRKAVNRIEDSDSDAGTPVKKFDAKSNGDTNDKDEKLAYLINLYPNRDTDDLQEVLITVDWDLDKAKSRLSTTKKRKKTSSKSNKKKRRKGRNMDEEDGEPDSDEKTYKSKDLQEVLITVDWDLDKAKSRLSTTKKRKKTSSKSNKKKRRKGRNMDEEDGEPDSDEKTYKSKVFDSDDDSEVEVSNDLTGDKKAVFDFMQTAILAELLMMHQCSQKKAEAIIAARPFEDWRDMVDKFQHNKYLDTELLNSAQVLLATRNVVEVLMKKCLRLSANMEKAVAAGASMIKEQPKGLSPELKLTAYQMVGINWLAVLHSQNVNGILADEMGLGKTIQVIAFLTYLKEANLLRETDGPHLIIVPSSTMNNWINEFERWSPSLNIVQYYGNPDERKDIRMGWRQGELDDVDVIITTYNLTSSTPEERRLFRVLPITYVVVDEAHMLKNMSTIRYENLVRINAQHRILLTGTPLQNNLLELMSLLMFVMPSLFAGKQNDLKSLFSKNPKITAAAKDQAFFEREQVKNAKQIMRPFVLRRLKSQVLKDLPLKTEEVIKCSLTEKQREMYKELMSEFSEEAGSGVPFNGPGMMMQLRKLANHPLLHRNFYDESKLRPMAKKLAKDSTYKETNPDHVFDDLYWMSDYAILGLTRFHRCLAGYGLPQEMVLQSAKLEKLDELLPVMKKDGHRVLIFSQFTMLLDGQTPVPERQALIDEYTEDSSIFVFLLSTRAGGLGINLTAADTVIIHDIDFNPYNDKQAEDRSHRLGQKNPVRIIRLLAENTIEEGMYEIAQEKLHLEAQVTENEENENTDRKSVLRLLKMTLGQDIHNKSLSLSPTKASNKSWDDIKVEEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MN98</accession>
    <name>A0A8J2MN98_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS9560</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5100451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MN98"/>
    <dbReference type="OrthoDB" id="70161at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5100451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="76" mass="8765" checksum="F1F06CD69522E9B8" modified="2022-05-25" version="1">MNQEKTPFAGTNTNSDLGTFYRECQSAPQLQTFLEEERTLAEQVGDLTKQLETFEINQQKYKDILTTLCQTDNNNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MNN1</accession>
    <name>A0A8J2MNN1_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial</fullName>
            <ecNumber evidence="18">1.3.5.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">HICCMSTLAB_LOCUS8604</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="18">Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>a quinone + succinate = fumarate + a quinol</text>
            <dbReference type="Rhea" id="RHEA:40523"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="1.3.5.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="16">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="16">Flavinylated by SdhE, about 5% flavinylation occurs in the absence of SdhE.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 18">Carbohydrate metabolism; tricarboxylic acid cycle; fumarate from succinate (eukaryal route): step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 18">Mitochondrion inner membrane</location>
            <topology evidence="1 18">Peripheral membrane protein</topology>
            <orientation evidence="1 18">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 18">Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.5.1" evidence="18"/>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5097231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MNN1"/>
    <dbReference type="OrthoDB" id="71672at2759"/>
    <dbReference type="UniPathway" id="UPA00223">
        <property type="reaction ID" value="UER01006"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045273">
        <property type="term" value="C:respiratory chain complex II (succinate dehydrogenase)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008177">
        <property type="term" value="F:succinate dehydrogenase (quinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006121">
        <property type="term" value="P:mitochondrial electron transport, succinate to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.700.10:FF:000001">
        <property type="entry name" value="Mitochondrial succinate dehydrogenase flavoprotein subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.80.40:FF:000004">
        <property type="entry name" value="Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000482">
        <property type="entry name" value="Succinate dehydrogenase complex, subunit A, flavoprotein (Fp)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:001062">
        <property type="entry name" value="Succinate dehydrogenase complex, subunit A, flavoprotein (Fp)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.100:FF:000001">
        <property type="entry name" value="Succinate dehydrogenase flavoprotein subunit (SdhA)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.100">
        <property type="entry name" value="Fumarate reductase/succinate dehydrogenase flavoprotein-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.80.40">
        <property type="entry name" value="succinate dehydrogenase protein domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.700.10">
        <property type="entry name" value="Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003953">
        <property type="entry name" value="FAD-dep_OxRdtase_2_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003952">
        <property type="entry name" value="FRD_SDH_FAD_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037099">
        <property type="entry name" value="Fum_R/Succ_DH_flav-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015939">
        <property type="entry name" value="Fum_Rdtase/Succ_DH_flav-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030664">
        <property type="entry name" value="SdhA/FrdA/AprA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027477">
        <property type="entry name" value="Succ_DH/fumarate_Rdtase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011281">
        <property type="entry name" value="Succ_DH_flav_su_fwd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014006">
        <property type="entry name" value="Succ_Dhase_FrdA_Gneg"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01816">
        <property type="entry name" value="sdhA_forward"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01812">
        <property type="entry name" value="sdhA_frdA_Gneg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11632">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE 2 FLAVOPROTEIN SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11632:SF51">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE [UBIQUINONE] FLAVOPROTEIN SUBUNIT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00890">
        <property type="entry name" value="FAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02910">
        <property type="entry name" value="Succ_DH_flav_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000171">
        <property type="entry name" value="SDHA_APRA_LASPO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46977">
        <property type="entry name" value="Succinate dehydrogenase/fumarate reductase flavoprotein C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56425">
        <property type="entry name" value="Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00504">
        <property type="entry name" value="FRD_SDH_FAD_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 18" id="KW-0249">Electron transport</keyword>
    <keyword evidence="8 16 18" id="KW-0274">FAD</keyword>
    <keyword evidence="6 16 18" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="13 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="11 18" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 18" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4 18" id="KW-0813">Transport</keyword>
    <keyword evidence="5 18" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="FAD-dependent oxidoreductase 2 FAD-binding" evidence="19">
        <location>
            <begin position="58"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="domain" description="Fumarate reductase/succinate dehydrogenase flavoprotein-like C-terminal" evidence="20">
        <location>
            <begin position="507"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="14">
        <location>
            <position position="335"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="63"/>
            <end position="68"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="86"/>
            <end position="101"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="270"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="291"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="303"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="402"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="435"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="446"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="451"/>
            <end position="452"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="Tele-8alpha-FAD histidine" evidence="17">
        <location>
            <position position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR000171-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR611281-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR611281-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR611281-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU362051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF00890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF02910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="CAG5097231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="659" mass="71850" checksum="EFC19E36555DACBA" modified="2022-05-25" version="1">MSGLLKLSSLLSGQPARVLNKLGLPVVSNRSFHHTPNGNAKSSDAISKQYPVVDHSYDAVVVGAGGAGLRAAYGLVAEGFKTAVITKLFPTRSHTVAAQGGINAALGNMEEDNWQWHMYDTVKGSDWLGDQDAIHYMTREAPKAVIELENCGMPFSRTQDGKIYQRAFGGQSLKFGKGGQAHRCCCVADRTGHSLLHTLYGQSLSYDCNYFVEYFALDLLMEGGECRGVIALCLEDGTIHRFHAKNTVLATGGYGRAYFSCTSAHTCTGDGTAMVTRAGLPNQDLEFIQFHPTGIYGAGCLITEGSRGEGGYLVNSEGERFMERYAPVAKDLASRDVVSRSMTIEIREGRGVGPEKDHIFLQLHHLPPEQLAARLPGISETAMIFAGVDVTREPIPVLPTVHYNMGGVPTNYKGQVLTTKNGEDAVVPGLYACGESASASVHGANRLGANSLLDLVVFGRACAITISQENKPGEKVGSLSPNAGEASIANLDHVRHASGSISTATLRLQMQKAMQTHAAVFREEKTLKDGCRKMSDIYKKLDDLQISDRSLIWNSDLIETLELQNLMLNAMQTIYAAENRKESRGAHAREDYKDRIDEYDYSKPLEGQQPKPMDQHWRKHTLTNMDPKSGKVSIDYRPVIDSTLNSQECASVPPAIRSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MQN2</accession>
    <name>A0A8J2MQN2_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Peptidyl-prolyl cis-trans isomerase</fullName>
            <shortName evidence="3">PPIase</shortName>
            <ecNumber evidence="3">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HICCMSTLAB_LOCUS10437</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="3">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 3">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cyclophilin-type PPIase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="3"/>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5101364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MQN2"/>
    <dbReference type="OrthoDB" id="193499at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016018">
        <property type="term" value="F:cyclosporin A binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024936">
        <property type="entry name" value="Cyclophilin-type_PPIase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071:SF561">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001467">
        <property type="entry name" value="Peptidylpro_ismrse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="4">
        <location>
            <begin position="42"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU363019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAG5101364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="190" mass="21230" checksum="79FEB6E6177F3F16" modified="2022-05-25" version="1" fragment="single">MTIRKIFFENSQPAKLIVAIKNLNSRPRCFFELRFEESKLLLGRIIIEVYSDVAPKTCANFLAYCLGTNNGLCYKNTPFYKIINGYLCQGGDVTELNGTGSTSIYGTEFECENFNLKHNVPGILSTLYSTDNTANSKFNLTFKKLQVLDNKCAVFGKIISGLSNIYKIDACGTQIGRPKKKIIISNCGLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MQP3</accession>
    <name>A0A8J2MQP3_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex</fullName>
            <ecNumber evidence="10">2.3.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">HICCMSTLAB_LOCUS10467</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>N(6)-[(R)-dihydrolipoyl]-L-lysyl-[protein] + 2-methylpropanoyl-CoA = N(6)-[(R)-S(8)-2-methylpropanoyldihydrolipoyl]-L-lysyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:18865"/>
            <dbReference type="Rhea" id="RHEA-COMP:10475"/>
            <dbReference type="Rhea" id="RHEA-COMP:10497"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57338"/>
            <dbReference type="ChEBI" id="CHEBI:83100"/>
            <dbReference type="ChEBI" id="CHEBI:83142"/>
            <dbReference type="EC" id="2.3.1.168"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:18866"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>(R)-lipoate</name>
            <dbReference type="ChEBI" id="CHEBI:83088"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the 2-oxoacid dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="10"/>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5101565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MQP3"/>
    <dbReference type="OrthoDB" id="202158at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016407">
        <property type="term" value="F:acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043754">
        <property type="term" value="F:dihydrolipoamide branched chain acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031405">
        <property type="term" value="F:lipoic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06849">
        <property type="entry name" value="lipoyl_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.100:FF:000013">
        <property type="entry name" value="Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.559.10:FF:000027">
        <property type="entry name" value="Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.320.10:FF:000002">
        <property type="entry name" value="Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.320.10">
        <property type="entry name" value="E3-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003016">
        <property type="entry name" value="2-oxoA_DH_lipoyl-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001078">
        <property type="entry name" value="2-oxoacid_DH_actylTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050743">
        <property type="entry name" value="2-oxoacid_DH_E2_comp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036625">
        <property type="entry name" value="E3-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004167">
        <property type="entry name" value="PSBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43178">
        <property type="entry name" value="DIHYDROLIPOAMIDE ACETYLTRANSFERASE COMPONENT OF PYRUVATE DEHYDROGENASE COMPLEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43178:SF5">
        <property type="entry name" value="LIPOAMIDE ACYLTRANSFERASE COMPONENT OF BRANCHED-CHAIN ALPHA-KETO ACID DEHYDROGENASE COMPLEX, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00198">
        <property type="entry name" value="2-oxoacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02817">
        <property type="entry name" value="E3_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47005">
        <property type="entry name" value="Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="Single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00189">
        <property type="entry name" value="LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51826">
        <property type="entry name" value="PSBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5 10" id="KW-0450">Lipoyl</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Lipoyl-binding" evidence="12">
        <location>
            <begin position="30"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="Peripheral subunit-binding (PSBD)" evidence="13">
        <location>
            <begin position="164"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="112"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00051775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CAG5101565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="452" mass="50034" checksum="FA20CEB7F140F340" modified="2022-05-25" version="1">MAWTARFFPIIKLGRGNRLLSITCINNGPVIPFKLSDIGEGIKEVTVKEWFVKPGDKVSQFDNICEVQSDKASVTITSRYDGQIKALHYKVEEVALVGDALVDIELPDDTSQEVASPGLGVNEQTISPPDKDNINLSNLIQSKGDTNEFSKTNQGENFNNNKILTTPAVRRLAAENNIDLKEVPATGKAGRILKEDLLAFLDKDPGKFIKPEGNHQEDENGGDPQIVPLIGYQKHMWKTMSQSQNIPHFVYCDECDITKLVELRNESKDYLENQGISLSFTPFFVKATSKALEKYPRLNSWLDEQAQALKTFKTHNISLAMDTPQGLVVPNIKDVKNLTIADIARELNRLQAFGQKAAFPLNDVTGGTFSLSNIGAIGGTYAKPMILPPQIIIGVIGKLQKLPRFDQNGTIKSANIISISWAADHRVVDGATVARFSNLWKFYLENPSLLII</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MQQ4</accession>
    <name>A0A8J2MQQ4_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to Gpm6b: Neuronal membrane glycoprotein M6-b (Mus musculus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS10858</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5102124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MQQ4"/>
    <dbReference type="OrthoDB" id="9993736at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031175">
        <property type="term" value="P:neuron projection development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001614">
        <property type="entry name" value="Myelin_PLP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11683:SF12">
        <property type="entry name" value="M6, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11683">
        <property type="entry name" value="MYELIN PROTEOLIPID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01275">
        <property type="entry name" value="Myelin_PLP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="60"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="106"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="155"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="240"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="287"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5102124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="311" mass="35369" checksum="9CABF1D2E439A48E" modified="2022-05-25" version="1">MTTNSRFRRCCSDSGAVVIPLNKRTVSNISVDRYSERSIHDEYLDDKPYRNMCNDCMTRVPYATLIATIMCCLGVGIFCGTMYRGATLTALLMNQVFNLRLSWLEALQLIFASIGACMAALGFMILCVGCLATGATRHKVYRAWSTRVGGRISCAVFMVITYILQFAWLLIFAFLVITTFVFTIFWGLCENPRVGSHTDCIDFNQFSFMFPNYTRNEDMKICGPQEVKLFCKDYVEKAEVMFILATVASILVVLSLIHYLMCLSANYAHIRDHEKFQELQELQYLQDPGDGDSPQHGMDTLSSHHHSKDRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MQT5</accession>
    <name>A0A8J2MQT5_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Similar to smad2: Mothers against decapentaplegic homolog 2 (Danio rerio)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HICCMSTLAB_LOCUS11601</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5103621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MQT5"/>
    <dbReference type="OrthoDB" id="5794312at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071144">
        <property type="term" value="C:heteromeric SMAD protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070411">
        <property type="term" value="F:I-SMAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009653">
        <property type="term" value="P:anatomical structure morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030509">
        <property type="term" value="P:BMP signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009791">
        <property type="term" value="P:post-embryonic development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050793">
        <property type="term" value="P:regulation of developmental process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051239">
        <property type="term" value="P:regulation of multicellular organismal process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060395">
        <property type="term" value="P:SMAD protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013790">
        <property type="entry name" value="Dwarfin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017855">
        <property type="entry name" value="SMAD-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001132">
        <property type="entry name" value="SMAD_dom_Dwarfin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13703">
        <property type="entry name" value="SMAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03166">
        <property type="entry name" value="MH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00524">
        <property type="entry name" value="DWB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51076">
        <property type="entry name" value="MH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="MH2" evidence="4">
        <location>
            <begin position="69"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="19"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="38"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAG5103621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="169" mass="19309" checksum="BD34AAB950AA3941" modified="2022-05-25" version="1">MVNDSPNDDLTNSTPRQSGKSDRVRKNGKSQSKDDTQKTSQYSPSNGTSNKNEEAMKELFSDYKVFENWCSIEYYEFNTQVGETFHVTNNSLEVNVNNYMNQSNNNTSFCLASITNKSRNKISEQIKKNIGQGIIMYLQTNGDIWLRQNCSQKINFHPASKLLDILLSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MRE7</accession>
    <name>A0A8J2MRE7_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Similar to ttk: Dual specificity protein kinase Ttk (Danio rerio)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HICCMSTLAB_LOCUS8484</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5096985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MRE7"/>
    <dbReference type="OrthoDB" id="20524at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004712">
        <property type="term" value="F:protein serine/threonine/tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033316">
        <property type="term" value="P:meiotic spindle assembly checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007094">
        <property type="term" value="P:mitotic spindle assembly checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034501">
        <property type="term" value="P:protein localization to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000131">
        <property type="entry name" value="Dual specificity protein kinase TTK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22974:SF21">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN KINASE TTK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22974">
        <property type="entry name" value="MIXED LINEAGE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="556"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="215"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="275"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="222"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="235"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="283"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="585"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAG5096985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="871" mass="98168" checksum="ED0E6AA9EB6AB283" modified="2022-05-25" version="1">MSQELKNDSLSVQNSSTADPDFQYSSNNEKSPQTVVNIHDSGMKKIDLAKGSHSSLINSMATVPDFIQSKSSNINRPNHDRLQDYKYSNDNVDDLKLSKQLFISNSPSDLAKEDISSTASLSSNQSDNSVQKQSNILSAQVSGLSTIIKSNSNLSNSNYIMKQPSIMSEASNVIHSTQERRVQSTLSYKIESTTGLDRQPLTNQYQSLSNQLATKTPLKQNPPISSSRPVPSVSHKNLFQTPQNKTSGDYVNSSHIQTPATIFSHWTQNNMMSTPLQNRMLGSGQTPGQSLSSKRDSQWQRNSDSSVKGARRPLAETSESRASVKNLPSHGKTLEINENQSREHLKTIPEKLSLVSSVSDFKENRQPPVRDISISQAELKFQSSENDTQKHFITSRSRSAEPIPDHYNTEKKNTTGEYVSKNYPICNLSKHNEYEIDKHRGELKNKPTTHISDTYSTEKRHTMGDHMPNTYKVNHQSRRTDYELEKHPSESKGILTKPLSERHASNRPTVTHESVAARENINKNSTVDNVKIQASVPSSTKKSQHGKTITVKNKEYMILGFLGQGMSGNVYRVQDLKTFELRAIKVVDLSRMDKENMQSSIQEINMLCKLQAPCIVQMFDYEIIGQTIYVVLEMGDTDLSKFIKTICAEKKLPVTMILYYWTEMLTAVKYIHDHGVIHSDLKPANFLLVRGRLKLIDFGIASTVHGDMTSVIKNVTVGTLNYISPEALMDVDETSHQNSKYKISYKSDVWSLGCILYSLVFGYTPFQHIRQNWAKIGAITNPSTKISFDLPPNSQPIPSILIDVIKRCLNYNPKERPSVCDLINIQYISITSNNTNISKPNIPHNTLVKIKQALDENEWRQFIEMMDNRIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MRR0</accession>
    <name>A0A8J2MRR0_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">S-phase kinase-associated protein 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Cyclin-A/CDK2-associated protein p19</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">p19skp1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HICCMSTLAB_LOCUS11934</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SKP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5104302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MRR0"/>
    <dbReference type="OrthoDB" id="2342932at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18322">
        <property type="entry name" value="BTB_POZ_SKP1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.710.10:FF:000018">
        <property type="entry name" value="S-phase kinase-associated protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.710.10:FF:000270">
        <property type="entry name" value="S-phase kinase-associated protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016897">
        <property type="entry name" value="SKP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001232">
        <property type="entry name" value="SKP1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036296">
        <property type="entry name" value="SKP1-like_dim_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016072">
        <property type="entry name" value="Skp1_comp_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016073">
        <property type="entry name" value="Skp1_comp_POZ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11165">
        <property type="entry name" value="SKP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01466">
        <property type="entry name" value="Skp1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03931">
        <property type="entry name" value="Skp1_POZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00512">
        <property type="entry name" value="Skp1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81382">
        <property type="entry name" value="Skp1 dimerisation domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0418">Kinase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="SKP1 component POZ" evidence="9">
        <location>
            <begin position="4"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="domain" description="SKP1 component dimerisation" evidence="8">
        <location>
            <begin position="113"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="SKP1 component POZ" evidence="9">
        <location>
            <begin position="195"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="SKP1 component dimerisation" evidence="8">
        <location>
            <begin position="303"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="150"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="151"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00033118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00033452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAG5104302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="353" mass="40405" checksum="9CD0A872503B9804" modified="2022-05-25" version="1">MSTTIKLLSSDQEVFEVDTKVAKMSATIKTMLEDLGLDEGDDEMVPLPSIQGPILKKIVEWAEHHKNDPPAPEDDDNKEKRSDDIPEWDVDFLKVDQQTLFAIIRAANFLDIKGLMDVTCKTVANMIKGKTPEEIRKTFNITPMVPTADDDAAKKEVEWSEEKDEELEKKKEKEKEKEKEKEADQFNYFYSMTNIKLQANDNEIFDVDVEIAKCSVTIKTMLEDLGMDEDDDEVVPLPNVNSAILKKVIQWATYHKDDPPPAEDDENKEKRTDDISSWDADFLKVDQGTLFELILAANYLDIKGLLDVTCKTVANMIKGKTPEEIRKTFNIKNDFSAAEEDQVRKENEWCEEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MSC5</accession>
    <name>A0A8J2MSC5_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS11663</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5103745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MSC5"/>
    <dbReference type="OrthoDB" id="7667137at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035161969" evidence="1">
        <location>
            <begin position="23"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5103745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="189" mass="21536" checksum="030D831D1A93B8B7" modified="2022-05-25" version="1">MTFFTFVLFMVIQILNIKKIIADDQFYTVNITRDFLKPYTNNLIKSTDVLTKDTYISFIESMDSDNALTILKANISIKDIQIWDSKTKNAINNLCNSSYPAGSVEENVSKIVSATVLGHLECPVAKGTYQTVFYKLDQHTLHFNKPIPCGDYVMDVTLDTADFKRVFDFTFSWTIPLAMNCEKDPSIIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MSQ2</accession>
    <name>A0A8J2MSQ2_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similar to Chst5: Carbohydrate sulfotransferase 5 (Mus musculus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS12010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5104454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MSQ2"/>
    <dbReference type="OrthoDB" id="7648254at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001517">
        <property type="term" value="F:N-acetylglucosamine 6-O-sulfotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006044">
        <property type="term" value="P:N-acetylglucosamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006790">
        <property type="term" value="P:sulfur compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051135">
        <property type="entry name" value="Gal/GlcNAc/GalNAc_ST"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000863">
        <property type="entry name" value="Sulfotransferase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10704">
        <property type="entry name" value="CARBOHYDRATE SULFOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10704:SF44">
        <property type="entry name" value="LD35051P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00685">
        <property type="entry name" value="Sulfotransfer_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sulfotransferase" evidence="1">
        <location>
            <begin position="109"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5104454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="404" mass="47268" checksum="7365128042CAE4F9" modified="2022-05-25" version="1">MFIRNTVISQQSDKLIRSTFFNSVLLLIFLHLSNADIRLRRNVNKYPDLLEIPSEGRNKSSVIEDVLNRQQRDIQLSMKNYKYPKSNHGSNISDIDDLLINKGGRPLRSVILGYWRGGSTFLGEILNSHPANFYHFEPLLDFGIVRIRSPPLAEEAIANLIALFNCDYDKLQHYIEYGKTTPWGFKYNPRLWKNCETYKNICWDSNYLREFCRLFPFQSMKILRLTLQIAQVLLQDEKLGVHMALLVRDPRGLVQSRKHPKWCQDSHDCSDPALLCADMVSDYEIATQLKKKYPHSFKVIRYEDLSTDPISESKELFNFYGLNFHSDVQNYLETHTLSDSGGKFSTFRNSKATPFHWRDDLDFEEVQEIQRVCSTAMRLWGYAMAANQTHQKEFNPVIRNYRLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MT13</accession>
    <name>A0A8J2MT13_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein SEC13 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">HICCMSTLAB_LOCUS12283</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Lysosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the WD repeat SEC13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5106484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MT13"/>
    <dbReference type="OrthoDB" id="364224at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030127">
        <property type="term" value="C:COPII vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031080">
        <property type="term" value="C:nuclear pore outer ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090114">
        <property type="term" value="P:COPII-coated vesicle budding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032008">
        <property type="term" value="P:positive regulation of TOR signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032527">
        <property type="term" value="P:protein exit from endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000017">
        <property type="entry name" value="SEC13 homolog (S. cerevisiae)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037363">
        <property type="entry name" value="Sec13/Seh1_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11024">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN SEC13 / SEH1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11024:SF2">
        <property type="entry name" value="PROTEIN SEC13 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0458">Lysosome</keyword>
    <keyword evidence="8" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="11" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0811">Translocation</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <keyword evidence="6 14" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="14">
        <location>
            <begin position="9"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="14">
        <location>
            <begin position="53"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="14">
        <location>
            <begin position="203"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CAG5106484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="311" mass="34313" checksum="ECC5DD05E7607123" modified="2022-05-25" version="1">MVSVLNTVDTGHEDMIHDAEMDYYGLRLATCSSDNSVKVFDLKNGSQSLVADLKGHDGPVWQVAWAHPKFGNILASCSYDRKVMIWKELGEWKKIYEHTSHDSSVNSVAWAPHEFGLILACGSSDGSISILTNNGDSWSTQKIPNAHTIGCNAVSWCPVIDPTFDAASHQRTGTVKRLATGGCDNLVKIWREEGDRWVEENKLEAHSDWVRDVAWAPAVGPPRAALASCSQDRRVVVWTSSDYASWKPNVLNVFDDVIWNVSWSLTGGILAVSGGDNKVSLWRENSEGQWSCISELNKGQGNLNNADQRVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MTF3</accession>
    <name>A0A8J2MTF3_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to cc_ep1.3_1.5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS7320</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5093994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MTF3"/>
    <dbReference type="OrthoDB" id="6929542at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035160742" evidence="2">
        <location>
            <begin position="23"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5093994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="294" mass="32895" checksum="3154C2E2ECBE6C75" modified="2022-05-25" version="1">MFGKLVVIVVLVTLVNNASLRAVEDESTLQNESTQLDEAGNPIVNNRNAPEAPPREIIQYLNCSDLHKYSLAEDTIQLSYSIILAASNPCIMKASVIILENNIFPGYGYAYNITGKRIVMVANEFKGPEQNHYIVGDNVLLVNNTYQGNLQVHEVAGYEVTAFYNVFDGKYRVHQYAATSILVFDNESKGNPFDVILTENPPNLTYGLYPNVLSNYETGAFNNVKLQTEYSLGKMSQETFDLTPMSVTRFLEEVKFGSKINRPVGATIVGKLQELIDNRISYDIYSSRDENGIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MVF9</accession>
    <name>A0A8J2MVF9_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Similar to ZNF350: Zinc finger protein 350 (Bos taurus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HICCMSTLAB_LOCUS8865</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5097763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MVF9"/>
    <dbReference type="OrthoDB" id="10004641at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24394:SF29">
        <property type="entry name" value="MYONEURIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24394">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="57"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="210"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="179"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAG5097763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="376" mass="43141" checksum="5C887BEE80BFF35E" modified="2022-05-25" version="1">MIIIKIIWLVIKNGDGYLPESQSSSDNEEIYPQNLLGVAYKTSVNNSKEVRDDDGKYVCTKCGKSYIASTSLRRHQRLECGVDPAQKCHICNRRFRHKFVLTAHINNCERKVLGIEKYLEDFGRTWRKTSKKVYQSLGLPGFRAVDSRPTLVCHRCHLLFSTLKIERVWSWCVKSEVSSNPEEENSTNPDLESAEPQKAPPRVNKPNTTFVCASCGRKYARKSSLRRHKKKCVVEPTLQCIICEEKFYKNYQLELHMKQCLKRIQTRTDSVVGCRDPGTVRAAVPGTSGTRDERQNEWNICVGICGPVDAVVRLQRLRERVQVAGQPEEAPEGRVWEQRKTIFLQRLLQEIQIPIRAHEPHICLSLAADNRPESLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MWT8</accession>
    <name>A0A8J2MWT8_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Mitochondrial (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HICCMSTLAB_LOCUS10751</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5101910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MWT8"/>
    <dbReference type="OrthoDB" id="10250117at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031071">
        <property type="term" value="F:cysteine desulfurase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11601:SF34">
        <property type="entry name" value="CYSTEINE DESULFURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11601">
        <property type="entry name" value="CYSTEINE DESULFURYLASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminotransferase class V" evidence="3">
        <location>
            <begin position="54"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG5101910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="217" mass="24415" checksum="B9ADF5265D38F41E" modified="2022-05-25" version="1">MMLRPSRTLVTALQRVKDCCPILRTVRQRSDVSEFESPITDEYKRGPAEGRSLYLDAQATTPLDPRVLDKMMPYLTSYHGNPHSRTHMYGWESEAAVEHARQQVADLINADKKEIIFTSGATECNNISVKGVARFYKAKKKHIVTTQTEHKCVLDSCRALQAEGFDVTYLSVNSNGLIDLEQLESSIRPDTSLVSVMTVNNEIGVRQPVEEIGKICR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MYQ6</accession>
    <name>A0A8J2MYQ6_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">tRNA (guanine(9)-N(1))-methyltransferase</fullName>
            <ecNumber evidence="1">2.1.1.221</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HICCMSTLAB_LOCUS13143</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>guanosine(9) in tRNA + S-adenosyl-L-methionine = N(1)-methylguanosine(9) in tRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:43156"/>
            <dbReference type="Rhea" id="RHEA-COMP:10367"/>
            <dbReference type="Rhea" id="RHEA-COMP:10368"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:73542"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="EC" id="2.1.1.221"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.221" evidence="1"/>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5108249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MYQ6"/>
    <dbReference type="OrthoDB" id="278300at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052905">
        <property type="term" value="F:tRNA (guanosine(9)-N1)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002939">
        <property type="term" value="P:tRNA N1-guanine methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18101">
        <property type="entry name" value="Trm10euk_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1280.30:FF:000001">
        <property type="entry name" value="tRNA methyltransferase 10 homolog A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028564">
        <property type="entry name" value="MT_TRM10-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038459">
        <property type="entry name" value="MT_TRM10-typ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016653">
        <property type="entry name" value="TRM10/TRM10A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007356">
        <property type="entry name" value="tRNA_m1G_MeTrfase_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13563">
        <property type="entry name" value="TRNA (GUANINE-9-) METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13563:SF13">
        <property type="entry name" value="TRNA METHYLTRANSFERASE 10 HOMOLOG A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016323">
        <property type="entry name" value="tRNA_m1G_mtfrase_met"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51675">
        <property type="entry name" value="SAM_MT_TRM10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 9" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SAM-dependent MTase TRM10-type" evidence="8">
        <location>
            <begin position="76"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="200"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="176"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="196"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="208"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="222"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR016323-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR016323-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAG5108249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="287" mass="32978" checksum="A72F135C4127DA1E" modified="2022-05-25" version="1">MTTIPSGTNLSTILDSHLVDKKLGETELNNISKNQLKKIKKKEKWLAHKSEKRLKERLKAKEKRAFARAHNINLGPSRKSLKKCTMENSSCKLTITIDMGFDDLMIEKDIAKLIKQILRCYTLNRRAPAPIQFSLTNFNNKSKEQMEKHNGYEHWDVKFFSESYCKVYDSKKIIYLTSESENIIDKLDHDSVYVIGGLVDHNGHKGLCHKLAVQAGVQHARLPLDKFLNMKTRKVLAVNHVFEIMLLITKGKTWQDAFLQVLPLRKNAKLVTQDDKDEINSSIESSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MYR9</accession>
    <name>A0A8J2MYR9_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Similar to pea: ATP-dependent RNA helicase DHX8 (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS13188</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5108340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MYR9"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0347">Helicase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5108340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="71" mass="8009" checksum="EB35D8A512660067" modified="2022-05-25" version="1" fragment="single">MLEKARNLTGRGAKIIFLNGRLSKAICSGLSWQAAKKEPGFDNVYITMPGREMVYIHPQSALYTVEPKPEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MZ27</accession>
    <name>A0A8J2MZ27_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similar to pol: RNA-directed DNA polymerase from mobile element jockey (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS12269</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5106456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MZ27"/>
    <dbReference type="OrthoDB" id="7555282at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33332">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5106456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="525" mass="61072" checksum="4B9ABACCD0F67C9A" modified="2022-05-25" version="1" fragment="single">MLRPKKDISINTLKISLDNSTLSNHCSNKFPDLINNNEIIATDPDTKLHIIGKYLESINAPRYTNFGTTTKLSVDTHATTHAMNKFASDINKCLHNNMIVGAALLDLEKAFDSVWIDGLIFVLEKNNFPRGLIFLLIDMLTGNYFYTWDGLSLSTEKFSILEGLQQGRVLSPILFNIFDSFTNDATKLEENGVHSISFADDRVIYIADPNVDIMKAKLQDRVNKINDHYLRWNLKINGLKSEIIFFRRPCKQIKVSQYNRIKAAKITITDHLGLKTDIPVKKTVKYLGVTFDHLLHMTNHHKAQLEKAKKAIKINSRIFYNRNLSPKAKLICYQLLIRPLITYAAPILWNMNHTVMRLERSALRSCIGMYRKPETEYRERLSNKKIYKEANITRIDCFYLKLGRNYYANYRNIENPTMDELICPDDNICLNACASGYVTPEMFTFCDRRGLLQDGNNLPIIYHARRHCFNKKLTTELFEESNKMFSTSLPKVDLCDTHRLNKNYWWLQTDAEYLDEIRRRTVWDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MZ77</accession>
    <name>A0A8J2MZ77_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="2">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HICCMSTLAB_LOCUS12494</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="2"/>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5106906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MZ77"/>
    <dbReference type="OrthoDB" id="2248014at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050185">
        <property type="entry name" value="Ub_carboxyl-term_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646:SF35">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="USP" evidence="8">
        <location>
            <begin position="139"/>
            <end position="1009"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="7">
        <location>
            <begin position="728"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="300"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="309"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="351"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAG5106906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="1018" mass="113626" checksum="AC73E9D8583FCAB7" modified="2022-05-25" version="1">MDNQIGGVEVGDIPMIESSSINDSSDIPELEVSESTSLSPLTSSLDHNLTIQEDNVLADVNMGIAETWDGPSTPASNIAIPLPPPPVHDYLDVVGADPISDTEGVEHGPFLSPINNLFADSSDIQEDAVVEISTTAGVCGLKNLGNTCFMAAGLQCLAATPPVLQYFLEVQQSDEKLLPAGSLMTHFSALLTKMWSRKYMVVKPTEFKQTLGAYHSQFKDYRQHDCQEFLALLLDSLHEQMNTAKVAKNCLQQQQVPATITTANSINSNKKIENVPSMPPMMSSTAVSTDDIAVTASTNANDDYMDTYDNSPSSDCPNSPNVTMAGSPKDLDSPMGDLDSTANSPRGSPLNEDEETLDSDETLDTKSSFIYNKVYDAEMNDSNNPLRLDLTQLSKKNTHLHGFYDILKDAKTSNANFLVTPQECNNEICYDSQKFQKDNLRRTTALDNSNLTENHDFDNKTLSIKRIKEVNVQKNNCNNDCLSNNSDTECDNNGLEKCNVKRMKLEDHEKKNHRHIDGDIDSNINNTSDNNLCSRTFVNCENGAIAEQDEIEADKHWAKHLRSNRSIIVDTFQGQFKSTVVCAVCKHVSVTYEPFMYLSVPLPHAMERQLNVTYIPANNDPPIRCVVSFNKQSRIGKLKEELLKTLGKDDVDSCNIAFAEVLENHISKILDDNLMLRCVNDTNRSIYAFELMDPPDAYTSTPEGNTDRVIETEPCQNGTSSGEEIGPCTICLEELDGDLKRHSGDNCTVVMCEPCIENYFKTRTESRVCPVCNVQVEKSSFTKIDQTGRPRPAIRILNVPLVLRHDTNEAPNNRKSTKLFGYPHLVRLPSRVNAENLHQVVRRVVPHEGEYTVHFVDGQGRHCSRCMYNVHCTGCSVPDTGMVDLRTSDTLAIRYTENVPDIEPPMEHISVRKQRPPHPLSLFVFHECVSMKLDDKVTFPLAGLSLGKHMYDLYACVCHYGGVSAGHYTAYAKNPHTDVWYHYNDELTSKQKPQEEDFSNAYILFYSRRETDSKPCNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2N0L5</accession>
    <name>A0A8J2N0L5_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PWWP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS13708</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5109072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="641149at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010369">
        <property type="term" value="C:chromocenter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000313">
        <property type="entry name" value="PWWP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16112">
        <property type="entry name" value="METHYL-CPG BINDING PROTEIN, DROSOPHILA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16112:SF16">
        <property type="entry name" value="SIX-BANDED, ISOFORM H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00855">
        <property type="entry name" value="PWWP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63748">
        <property type="entry name" value="Tudor/PWWP/MBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50812">
        <property type="entry name" value="PWWP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PWWP" evidence="2">
        <location>
            <begin position="1842"/>
            <end position="1896"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="146"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="282"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="387"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1228"/>
            <end position="1388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1458"/>
            <end position="1479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1929"/>
            <end position="1986"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="166"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="202"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="214"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="290"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="314"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="396"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="420"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="489"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="566"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1232"/>
            <end position="1245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1246"/>
            <end position="1262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1263"/>
            <end position="1276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1283"/>
            <end position="1295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1304"/>
            <end position="1352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1367"/>
            <end position="1380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1458"/>
            <end position="1469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1470"/>
            <end position="1479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1947"/>
            <end position="1959"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5109072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="1986" mass="213220" checksum="DD46B1908BF4E2CE" modified="2022-05-25" version="1">MLQVATRPWSPDQGKTREMTKLCNHKRKLLLPVAAASPVASCTPVVSSSTLPVPGATAINARADSPTSSDKSKKVSQLIAQRERAIAVASATGIQSLPSSNGSQPGHHFNQRNQMWGQQTRTNVPSHQSPPAASIQNITCNSLDRVPPLHHHIPPTAAWTDEVARKKAKTSKSLVKKQRHHMAEIRSIEQASPGPEDEFNDNKPQPNQIGSTINSSNTNNNTATNNNNNNNNNNNNNNNSNNSSPSFLDDPSGYLAQQTALLNSTISRQTGVSSSQMMINNKMPSQVHGNNNSNSNNNTINNNSNNNYILHQKPSSATSPTSTSICNSGKNHATSPIVVHSSMTPTTMANDSDTGSCHGCVTSADTQSFITDQYKQQQIHRQYASVMHTDQRDDPVTSSTYGDRFASTNQQMDSWPIQGGTISTSHGSPVSTNSPANSETPVSSLSQPATPQSLISSQPSTPHSYSQPPTPHSHSQAPPQSLTPGQQPSQSSVIININTTNTNPNNNNSSNNNSINQDQSQASLSMTSASSTISPSSSPPQAIITGSSSAERELTTSHSISHKSSHQSQTRQSTTPEGYAPHPHTINPIQRISMIPYSGNATVITTMASGHTFSSNTITSVLAGRANTATVSINTPSGISNILSSKSHSSSLSTPTASIVVSSHHSNSTPIIHSQSQTMVSKSPLEMVQSVVSSIQVPQPVSSCSSLPHHQEQSNVQVHNVIASGGVLKHSTGSTLPPGHIFVSSGGQLIMASTGSGISGVMAPPPPKIISNASSMPPLSVSPMVTSVTGAVSQVIPAVGVAQQVIGQPTVLVNTIQTPVLIQPSVMTMDSLHGQNVQIPHLTVATGNVLQNAQSILEANQDVTRAVTTNQNIVNRQPNLLSPESTVTKKKVYKKRKNNSQTVASMLHIASSQQNTGMLMQSQSNFAQQNFQQSIGGPMLQALTIVPGKGGAPAQLVMNGQTGATSAQFNTQQIITNPQPTQQINLLQPVNLLNGATGMVQNFPTIQQFIVPGLGSMVMSADGTATLLQDTGNLGMQLQIQNVNGQNVLTPIQSHSGIFSPSQSILAAGPAGMVIRAPQAAGGKLIQQHSPGTQFLSSNSGQFLVNGTTSFSNQLSPIVANVSPNQQMTFNTSQVRPSNIQGQQEFIQMNGQTLMVPCGTAQNIAVSSASNQQNTTFVQQNTTIVQQQTTMVSNNQIPDFQSVATSNGNVEQSLNLDHNQYILSAGMIQGKSPSSPKSTISSPSSEQGVEQIHQQQFSLTSTSGNKNHNNNNHSSGSGSGSVGIIIDQNGQQGDQLSPSMVRHSVSTQTAGNQANNAQSAIMRQGSPPDTTTHSPGNSQRSNSPAVDTTSHGAASPAPPISARHHSSSTPMVHCISSSEPDSGDLQNPGDDWRIQGITTKELTLSQVGLQHGKTYVESTVTTGIQVGNHRVSPVTRGFTVDLHQPADTTHPENTYVDSQENMDTSSPNHSNTTDTTNIKTTTTTTTTTTIITPSDSNNSNSLSNNPQHYQSVVHPPYNCIAPPDNDNGIVYCQQQQQHQNEIPPLDHADYTHLPGNKLTRGNQESLTPHSLDSFVEGETTVMEVQDGHELNPTLELNPQSYKYRNDSRQQEFHRYHHNHNHNHNHNHNPQFQQLQFLHHHQHRQHLEHQNLLEQRQLGSMSRNAVVSSNSNGETYLLPATVTSQKVINFNNVGEVGATPTPPALYRHLYDLNCRSDPNGSNGSNGIAVVDYHHHYHHHNPNSANKTLFVVGNSNNQFGCDDQSEDDSDDSSDDDCIWQIYTPETLKQTEGVVSTVRCEGREHTLGQGIKRKLDSIHSMHSTLHEDQDVSESEGDKGNWEVKVGELVWGAALGSPAWPGKVESFGPPGSFTVSVRWYGAGETLTQVEIKNLKSLSDGLEAHHRARKRFRKSRKLNMQLENAIQEAMAELDNLSDPDTPNKIRKQFVQSTRSSKTSLSSTSHGKNRNSDSKKSKKLSSSQQKIVPKCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-10-16" modified="2023-09-13" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>S6CVS9</accession>
    <name>S6CVS9_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Cc_single_18.14</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">CcBV_18.14</name>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS6229</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Philos. Trans. R. Soc. Lond., B, Biol. Sci." volume="368" first="20130047" last="20130047">
            <title>Functional endogenous viral elements in the genome of the parasitoid wasp Cotesia congregata: insights into the evolutionary dynamics of bracoviruses.</title>
            <authorList>
                <person name="Bezier A."/>
                <person name="Louis F."/>
                <person name="Jancek S."/>
                <person name="Periquet G."/>
                <person name="Theze J."/>
                <person name="Gyapay G."/>
                <person name="Musset K."/>
                <person name="Lesobre J."/>
                <person name="Lenoble P."/>
                <person name="Dupuy C."/>
                <person name="Gundersen-Rindal D."/>
                <person name="Herniou E.A.Drezen.J.M."/>
            </authorList>
            <dbReference type="PubMed" id="23938757"/>
            <dbReference type="DOI" id="10.1098/rstb.2013.0047"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5092564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="HF586473">
        <property type="protein sequence ID" value="CCQ71280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S6CVS9"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5092564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCQ71280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="88" mass="9974" checksum="879DF3FE3E3D66E4" modified="2013-10-16" version="1">MESPKNVVKKLFSLLPILVFLKKSSSNLKKDTDKEKADNVNKEELSKKFSLTTFRSLNKVTGYCDASAMVTYGVDDVPRVQHMFGCWP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2E5S7</accession>
    <name>A0A8J2E5S7_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to plcA: 1-phosphatidylinositol phosphodiesterase (Listeria monocytogenes serovar 1/2a (Strain ATCC BAA-679 / EGD-e))</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS944</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001114">
        <property type="protein sequence ID" value="CAG5074172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2E5S7"/>
    <dbReference type="OrthoDB" id="7697653at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006149">
        <property type="entry name" value="EB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39069">
        <property type="entry name" value="ECDYSONE-INDUCIBLE GENE E1, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39069:SF8">
        <property type="entry name" value="FI17111P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01683">
        <property type="entry name" value="EB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26146">
        <property type="entry name" value="PI-PLC_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035170663" evidence="1">
        <location>
            <begin position="22"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="domain" description="EB" evidence="2">
        <location>
            <begin position="469"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="domain" description="EB" evidence="2">
        <location>
            <begin position="603"/>
            <end position="648"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5074172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="714" mass="80276" checksum="08F578C44CFA1D0F" modified="2022-05-25" version="1">MLTRILLMCLTFGSIHQLVSCMITNGYKDHSDFISKIPDTKLVRNLALIGTFHSAAFKPMKYVRTQNLTISEQLQAGIRVLDIHLSVDFDKLKVYYNLEYLNCTFDDVLTEVQSFMTLNPKELVIILLSVNLNFFLTDSISCEVLDSYVGRWQKRGLKLVQDWSLLEDYVGEHRGHVLLGHVRESNFKSCSVYLPCEVQDNWNVTDAEKKWKFVKDSQDGMLFAYHPYHSCYINYLASYNPLIMNYWQPDSDDGADELKLGMMRIEDVNERMAGYFRNPYDTLDMVVTEFPIFGGLGQSCSRNEDCLLKNSECRGSTCKCLANFIKLDGKCMPLIGGTCEKEDDCRIVNTNCDGVCKCREGLGPAEDNTYCRDNTIRIGSSCKGDDCNSIRNAVCKEAKRRSLLSSLKEKENTRFKCQCKPDHYQLGKECAKFAKGLKDKCEDRVGCARIPGSRCDKVSMTCQCLEKYFYQVEDTCFKKAKGLGNECKTDEGCTKIDNAECLDNTCQCKEEFYNWEGVCYKYADNLGEICYNDGCKKLNGSECVEGMCKCKVGWYSFGNKCFEKPTAIGAECKSDDGCEQISGSKCDNGVCNCKTGFYLAENSGICLPLPKDLNKNCVDTQDCKTLFSECSNGTCDCREDYVVHNGVCYGLPGAQCYGDKDCASVSYYCDSGTCQKAASVNGKLVGCFSDSLDDTLMVFFWQLLATGGHWGSIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2E873</accession>
    <name>A0A8J2E873_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Similar to MKS1: Meckel syndrome type 1 protein (Homo sapiens)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HICCMSTLAB_LOCUS2409</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Cilium basal body</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001117">
        <property type="protein sequence ID" value="CAG5077251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2E873"/>
    <dbReference type="OrthoDB" id="10263520at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036038">
        <property type="term" value="C:MKS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010796">
        <property type="entry name" value="C2_B9-type_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12968">
        <property type="entry name" value="B9 DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12968:SF4">
        <property type="entry name" value="TECTONIC-LIKE COMPLEX MEMBER MKS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07162">
        <property type="entry name" value="B9-C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51381">
        <property type="entry name" value="C2_B9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0966">Cell projection</keyword>
    <keyword evidence="3" id="KW-0970">Cilium biogenesis/degradation</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAG5077251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="466" mass="53958" checksum="7A8F759572C4913A" modified="2022-05-25" version="1">MFSRNSGKLKIAGEYRVNQPIDHFKLKIKILQQKSPLVDLFDSEEEIHDSNYLESEEKTITWQEKIFSSSEVKLYTEEKNCKSQLQKDYHELITSENVQGSRLFTYTAEDSYRRNKTAVTSSNYSSFLSKKNASALPGIQNRKPFNERYNKQVVDSSPTDSRIRSSHYLYLDCRVMHVMVDLSSREQVSSDPETSEILLCTLTYNKAGKVLSIDPDINNAEPYIIESIGMNYEYWIEHVSEIPKVYYQDKNISDIELPPANILRLFLTLDFIEARNFNYNSIFITYTIDLPKFWSTNHRERLYGRTQRCKMINKSAHFSYVAEITLDLDLNCMNDVPSWPYLLISVGSLDNWTRYRIEGYTSIPLPSSSGSYEFRLQTWRPVYGVINALRRFFTGGTAELEDIAYCGIPRDHEGKTLDKKQLRVVPSGTVGLRVNIVQQSKSSSKNRGYKFQERLNSGSLLNTKGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2E882</accession>
    <name>A0A8J2E882_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Isoforms B/C (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HICCMSTLAB_LOCUS2424</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001117">
        <property type="protein sequence ID" value="CAG5077311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2E882"/>
    <dbReference type="OrthoDB" id="2448405at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09631">
        <property type="entry name" value="DOMON_DOH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057443">
        <property type="entry name" value="At5g54830-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019545">
        <property type="entry name" value="DM13_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045266">
        <property type="entry name" value="DOH_DOMON"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005018">
        <property type="entry name" value="DOMON_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052126">
        <property type="entry name" value="Spindle_Org/Thrombomodulin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24036">
        <property type="entry name" value="SKELETOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24036:SF5">
        <property type="entry name" value="THROMBOMODULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25489">
        <property type="entry name" value="At5g54830"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10517">
        <property type="entry name" value="DM13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03351">
        <property type="entry name" value="DOMON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00686">
        <property type="entry name" value="DM13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00664">
        <property type="entry name" value="DoH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51549">
        <property type="entry name" value="DM13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50836">
        <property type="entry name" value="DOMON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="DM13" evidence="3">
        <location>
            <begin position="23"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="DOMON" evidence="2">
        <location>
            <begin position="169"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG5077311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="566" mass="63108" checksum="012C3320E302172E" modified="2022-05-25" version="1">MQVDFGDIVFPAHLEIPRPRVLPEFSRLAHGLRSGNISILDSKTLYIPNLHYDGAGPDAYFWVGTGPEPNTMGFKVPNEVGGLTKLRGYQGEDIEIVLPGNLTVFDIDWLSVWCVQYKHNFGHVMIPKDLDVPPALGQTKITTSSSPPIAPMPPITLTELSNCKELLDGRVQVQWELMGEDVQIRVSGRIREDQYIAFGLSGREGRREMTGGDVVVVGYDKRKKRFFAEDYYLSDLAQCDGRKGVCPDERVGGKNDAVLIDGERKNGVTTVTYMRPLSTNEPEKDRMIPNGATSIIAAIGTLNSRGEANAHTQSDRTDEDIKIDFTSKNVHECINSLYDIPNEEIELDAWPIETIIDENNLTARIGQTGGKRGYSKITGQPSWGICWYINDLLIPEITVERGQTYTFIVEGGVDPSNPARYHPLYITASPEGGFGQKTDEQQRDERVFAGVDWNDEGYPYPTAAGRFCEWAHKTVDMSENSLTFASFFDTLRLDCDQGEPAKLVWTVAPDTPDLVYYQCYTHKNLGWKIHVKDPGYKSELTAASDSIMSSSLITLLIITGIHSLLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2E8L1</accession>
    <name>A0A8J2E8L1_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS337</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001114">
        <property type="protein sequence ID" value="CAG5073394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2E8L1"/>
    <dbReference type="OrthoDB" id="7700372at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2590">
        <property type="entry name" value="BEN domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5073394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="201" mass="22713" checksum="DB03E65FED616BF3" modified="2022-05-25" version="1">MENDSDGGVEESRSTNKRTTKSREEKEDNGARNQDDLSSTDVDGGGGDNRSLMRILSTLSREVKTMKRIQLQMEERHDNQPPPPNARVWTFSLSIANAHSKNFFVEIGRAGSNVFVSRDQWKTANSRANYSSMGVALFQALFETYVMLRSNLRGGSSKIDKNQPRRFALDQAIITTITGNNLEEFICPQRRKTQLGWEKPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2E9V2</accession>
    <name>A0A8J2E9V2_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Similar to CG4928: UNC93-like protein (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HICCMSTLAB_LOCUS1048</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the unc-93 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001114">
        <property type="protein sequence ID" value="CAG5074380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2E9V2"/>
    <dbReference type="OrthoDB" id="10010517at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055120">
        <property type="term" value="C:striated muscle dense body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015459">
        <property type="term" value="F:potassium channel regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006937">
        <property type="term" value="P:regulation of muscle contraction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043266">
        <property type="term" value="P:regulation of potassium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051951">
        <property type="entry name" value="UNC-93_regulatory"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19444">
        <property type="entry name" value="UNC-93 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19444:SF11">
        <property type="entry name" value="UNC93-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="141"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="175"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="202"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="227"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="358"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="447"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="475"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="506"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="542"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="565"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="46"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG5074380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="599" mass="65180" checksum="C9AFC16B6E26E42D" modified="2022-05-25" version="1">MGSLPNLHELSRDKENPPIVHRPSPIGGFGPIKLPPQPPPLAQTNRRVKSSSGHHHTLWDNDVMLEHMTTYSPISCRSARASALSCRRRESMTSSATGTSSVRRLIAAVRASTPSAASGNNIYSTGYLGCNIQPRPSRKLVIRHCAALFLGHMTISAATLPLLPLQAGLGAFNSHLGPILLAVLYGIATITSMLSTVVIQKLGTNIVICLSHFVTILFLVTHLYPKWYVLLASYALYGMTLSPWLLSRTSHVNICASNLSVIYATDPDDPDDPDDTKRECILRRLNRILKLAEDLGLAVGCLIAGLIIKVINPLTKALDSSDLEDVGSTCGAEYCPQETYFYNQTLLLPTMAVDTAKVILSVYLGLGALAFGISCGFLDSRLREPQSSLDHQSVRQHLKSLKQSFQDPKLQLAAPLTLFIGLEQGFIYSDFTEAFVVCALDGAGPVIISFLTFALLQALAGVTLSMLMRHIRRHFVVAVGFAFHACLLLALVTWRPAGDDPALFNVISAAWGVCNAIWETLILTLLLGLYPSSWQAPLSTSIFWKYLGLFLALGLHGVVCTRLRVLGLGTSLILAVVPYIWLELRLARRGKCLVTTSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2EF97</accession>
    <name>A0A8J2EF97_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS357</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001114">
        <property type="protein sequence ID" value="CAG5073414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2EF97"/>
    <dbReference type="OrthoDB" id="6482909at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="499"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="499"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="636"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5073414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="636" mass="72631" checksum="A6AC4F4CCB0ABF12" modified="2022-05-25" version="1" fragment="single">IFLCIVTIMANNGRKRKSFIDSLPDRVFHGFTFRQGRPLKDGARRLICLHGESHACDASGTLSATDDFNPDAEIKARFTRDLYIATKHQFRTLQIIYDEIALLHEEGAALLSFNDNNRKMQAWLENRVLPEVTSIGDIKLQLNDPLFKNINLHNAGKTEIEFVQDEEGQNTAMILVDANLLSQLETMTLFIQSTDHKFEGVDNLQLTSISTKHMDYILPLVWIILSDKNEKICESILRKILTLQPTLSPTAIYSEFDSDYWRAVKAVFPNVIIKGMFLSHCKIMINTAKLKNINLTDERTMSILSKIISMSLLPADKIVNSLREFVGSTMTNQDFENLNELMTFYDEKWLTSIDVENYSFYNDSMSLRKNGELILQDMKNRLKKVNALWNLIEEVSSINSQIHFHQDNLAKKGHFNIPSRKVKNIFTGVKNCKCISDAWKEIEAKVLSSIDLIMRTADNLTPILRNLSNSDVKIPIQFQLVNLTTDEENELIDADDELPILNSSDDEPIDDELPILNSSKDEPIDDEIPILYLSEDEPIDDELQILNSSEDEPMDDELPILISSDDEPIDHELPILNLSDDDHIDYEPIDNEPVNDEPIDTLDEEEVQGYIHSQHCLGCYEDSIEIGYRPCTYAPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2EGX3</accession>
    <name>A0A8J2EGX3_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS1413</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001116">
        <property type="protein sequence ID" value="CAG5075259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2EGX3"/>
    <dbReference type="OrthoDB" id="7701581at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5075259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="128" mass="14431" checksum="797208C02199A461" modified="2022-05-25" version="1">MDSEMEMPEYVVSSTEFKTKILSQHEKFKKASLLVKDLPILVAEKSNDLYLQRMENLRDLCDAYRNGDEVMIVKVNSIFVLSLEQKLLLIRGFALISSAIFPLLARSVDDSPAVPALADRDTLPPPSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2EIV5</accession>
    <name>A0A8J2EIV5_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS926</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001114">
        <property type="protein sequence ID" value="CAG5074154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2EIV5"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5074154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="84" mass="9887" checksum="7F6C11C758681166" modified="2022-05-25" version="1" fragment="single">KQKNNSDSPDRESNPDLLVTHQRLGQLSYLRHRPRCNYLSIVTYTNAQFEKQKNNSDSPDRESNPDLLVTHQRLGQLSYLRHRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2EME0</accession>
    <name>A0A8J2EME0_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">alpha-amylase</fullName>
            <ecNumber evidence="4">3.2.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HICCMSTLAB_LOCUS681</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endohydrolysis of (1-&gt;4)-alpha-D-glucosidic linkages in polysaccharides containing three or more (1-&gt;4)-alpha-linked D-glucose units.</text>
            <dbReference type="EC" id="3.2.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the glycosyl hydrolase 13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.1" evidence="4"/>
    <dbReference type="EMBL" id="CAJNRD030001114">
        <property type="protein sequence ID" value="CAG5073909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2EME0"/>
    <dbReference type="OrthoDB" id="550577at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004556">
        <property type="term" value="F:alpha-amylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043169">
        <property type="term" value="F:cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006048">
        <property type="entry name" value="A-amylase/branching_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031319">
        <property type="entry name" value="A-amylase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006046">
        <property type="entry name" value="Alpha_amylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43447">
        <property type="entry name" value="ALPHA-AMYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02806">
        <property type="entry name" value="Alpha-amylase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00110">
        <property type="entry name" value="ALPHAAMYLASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00632">
        <property type="entry name" value="Aamy_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha-amylase C-terminal" evidence="7">
        <location>
            <begin position="216"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG5073909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="334" mass="37967" checksum="939D035C5EEB4804" modified="2022-05-25" version="1">MSFMNVDLAQFFTVKLVDAAKHIWPGDLSVIYSRLHNLSIDHGFLPQSRPYIYQEVIDMGSEVISKQEYNSLGAVTEFRYGLEVTSGIRGENSLKWFKNIGEEWGLLVDKDALIFIDNHDTQRHPGVLTHKEPRLYKMAVAFMLAHPYGKPRIMSSFSFENSDQGPPADSLGNLLSPLKENNNTNGCADGWICEHRWRQIVNMVEFRNVAAKEPICEWWDNWNNQIAFSRGSRAFVVINADQFDLNWRIKTCLPEGVYCDVISGNLEGKSCTGKKLVIDADGFVNVNIAMGEEDYVVAVHININENDLRASTSDIVYFEKKVVSCRAFQKTKLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2ENB2</accession>
    <name>A0A8J2ENB2_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Myb/SANT-like DNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS1479</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001116">
        <property type="protein sequence ID" value="CAG5075325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2ENB2"/>
    <dbReference type="OrthoDB" id="7656790at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044822">
        <property type="entry name" value="Myb_DNA-bind_4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13837">
        <property type="entry name" value="Myb_DNA-bind_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myb/SANT-like DNA-binding" evidence="2">
        <location>
            <begin position="101"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="217"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="217"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5075325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="331" mass="38577" checksum="6556016FCBA919A6" modified="2022-05-25" version="1">MDESHFYSRHYEYNDLIYEISGTKEFHNKMITDWNYATSYLKEMVENQVLDEDVHVNDQVFDDNVYVNEEESSNPNQYEDFNDTEEVVEKDKNDKDDGSIWDNASIKLLLHEYLIRKNKFRSPKMKKITLWREISAEFEKQNLIFSADALSKKFGNMKTTYAKIKKNNSKKTTGAARKPWVWLKSMDEIFHNDLSINFRHDVVTSMPADVSDEVLNLSNSSSNRENGCGSSSSSQASASSSNVVHSGDDSDKISQKCYKSARGKNIYQQRQKQLDLDSDKIEVMRGLKDTLEQCQNLQKENLSIWTQKMNDLTEAYKQRNQLLKQILEFQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2ENG5</accession>
    <name>A0A8J2ENG5_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS1617</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001116">
        <property type="protein sequence ID" value="CAG5075463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2ENG5"/>
    <dbReference type="OrthoDB" id="7698113at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34239">
        <property type="entry name" value="APPLE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34239:SF2">
        <property type="entry name" value="TRANSPOSABLE ELEMENT P TRANSPOSASE_THAP9 CONSERVED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5075463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="340" mass="37982" checksum="F45D8CEC109DAF8B" modified="2022-05-25" version="1">MSKRKNDSIVIELRKQIKLMQEQLDAVQPLEEPSEPEVSDTESDTSQKDGLETDLLANFQDEESVEEKENDDQNKIRDQKTDPIPPSLNAEQASCSKTLSEEVLKVLGEDPLASKAIDIKLHSSLSARWKHWTANGVPKQEMEDLLSKYARQEGLEAPKLNLEVSSNLGESAVKRDKFITENQKSVGSALSAVGSALSMLLEEDESIDKLVFVERLSDATKILSDLHFRLSESRKAFILPGMTKQSKNVLSTTKIDEFLFGKNLSDKLKEARALDKLTQSMRYQQSKAGNQNPSTAFLKGADLSIIRKTAGWSNSSKMFAKVYNRPLLIDNQVFAKAVIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2ENL3</accession>
    <name>A0A8J2ENL3_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Similar to inpp5f: Phosphatidylinositide phosphatase SAC2 (Danio rerio)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HICCMSTLAB_LOCUS1739</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001116">
        <property type="protein sequence ID" value="CAG5075585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2ENL3"/>
    <dbReference type="OrthoDB" id="405996at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045334">
        <property type="term" value="C:clathrin-coated endocytic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043812">
        <property type="term" value="F:phosphatidylinositol-4-phosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001135">
        <property type="term" value="P:regulation of endocytic recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034753">
        <property type="entry name" value="hSac2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022158">
        <property type="entry name" value="Inositol_phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002013">
        <property type="entry name" value="SAC_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45662">
        <property type="entry name" value="PHOSPHATIDYLINOSITIDE PHOSPHATASE SAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45662:SF8">
        <property type="entry name" value="PHOSPHATIDYLINOSITIDE PHOSPHATASE SAC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12456">
        <property type="entry name" value="hSac2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02383">
        <property type="entry name" value="Syja_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51791">
        <property type="entry name" value="HSAC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50275">
        <property type="entry name" value="SAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAC" evidence="2">
        <location>
            <begin position="187"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="domain" description="HSac2" evidence="3">
        <location>
            <begin position="606"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="913"/>
            <end position="934"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="967"/>
            <end position="990"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="913"/>
            <end position="925"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="967"/>
            <end position="976"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG5075585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="1075" mass="121874" checksum="E72B6ACE7C609833" modified="2022-05-25" version="1">MMPYELFRCDTHFIFVKEQHSLWCEKNSGEFSVKSDWEWASANNLECLGIFYGIIGKIDQTSFMESKLMLIKDVSNVGELYGNHVIYKIKSVAFLELGSKNANINLLPCKKHNNSGINNKALGRFLDDAQKTGFAKTWGSIKSATNTIKNTTQQAATLATSQVKSTMIRRNGKDKEKLEKRLLDELTKVFSETDSFFFCETGDLTNSLQRRKNNTKLSSDENQPPLWKTIEKCQVETGFDHQPIFETFHLAIISRRSRFRAGTRYKRRGVDDDGKCANYVETEQLVWYHDHQVSFVQVRGSVPVYWSQPGYKYKPPPRIDKGEAETQVAFEKHFAEEIACYGPVCIVNLTEQSGKEKIIWDAYCDHNVTILINALSDILGEMGYCWRDSHGSICSQQGVFRINCIDCLDRTNVVQTAIGKTVMEMQFSKLGLIPPDGTLPSNIRQTFQSLWANNGDIISKQYAGTNALKGDYTRTGERKFTGLMKDGVNSANRYYQQHFLDETYQAAIDITLGNPIDIEKFKTSYLHSLHILDNCCVELIPVKPPNIELQFLNHPEILLATNIYTFMRYYLNRFKDLYRQASIDLMLGKTVSEEIFQERTEEEDNAATAIHVKLLIEDCKKLLISNSEEILGSWGLIDADPVTGNPNETEMDTILILTKDSYYIADYDDQIDKVTNYQRVLLSEIEMIEFGQPEISTSFFKNKQHHCIRINYCVNNESGYYHMFRCTNLRFFNNMAVVIKTDEEAIESLRAICEAFSVAIEIAALPEIPVVMNTSLVKKISKQIETKGSTGLLDISSFPQLTRNTSESQLHALKNAGTKAFNNMSEQFSKLNKLSNSFGNARKLSISHTDKKISSDKIEQNTQSKVVFTIDRCEPGIEAENYDFDTHSYDDSHENFEEDNSKVESVISSLENNSSNPKITILNTDGQEKDEKEKIVPPSTLNLVKKISHSSSEVDSDTDSRNFIEVDKNGERKSTSLEEGLPKNNITSSQSESALKSIKSNITNVTSPVATTAKEILSPFSKFAKGVQTFGANLDPRKLKSHQGTVSKNLSDHHLDQREQLIERWKGCKSMLIAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H1I0</accession>
    <name>A0A8J2H1I0_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="6">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HICCMSTLAB_LOCUS587</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="6"/>
    <dbReference type="EMBL" id="CAJNRD030001114">
        <property type="protein sequence ID" value="CAG5073753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H1I0"/>
    <dbReference type="OrthoDB" id="19653at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43142">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43142:SF1">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0719">Serine esterase</keyword>
    <feature type="domain" description="Carboxylesterase type B" evidence="7">
        <location>
            <begin position="27"/>
            <end position="539"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG5073753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="558" mass="63115" checksum="585CD456A6BFB606" modified="2022-05-25" version="1">MKLILKLEYCVISGIILTFTSFAAENEPIIKVHSGQLRGIKENNFFAFRGIPYAAPPIGQLRFRDPKPVEPWSGVRDATKFGNSCTQFDRYSKKVLGSENCLFLNVYTTNLTPQEPRAVMFWIHSSAFAIWSGNDDKFGPDYLVQKDVILVTINYRLDIFGFLNLDDESVPGNQGLKDTMMALKWVQQNIGKFGGNPNSVTIFGQSSGSAMVHYLTLSPLTQGLFNKAILQSSVASNPRSYVSYPMKDAAEQVSGIMGRSNEDLIVFLQNADPSDLLKAIQSLEFREEGYLINFPFVPSVDSKSKFPFLSILIIEAVKAGIRVPHLIGYTSKEAIRFKSGSYSQLYCVVIPDLTDEDYKEIAANPEKLLLHPNGKKFLEARNISVSDMKTFFYGDKEISRANAQQYIDLVSADFYWVNIHHVLEIQLSASKIPSYLYKFDYYSKESAVVQKMLNTDLEGTAHTEENFYLFNATILKKLGIDQPCKFPVEKVIQKQFLDLWTTFAKTGNPNLAVELGTVHWEPVDDPIEFKCLEISKDLKLIKEKNLLYQLKTQENVKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H4V2</accession>
    <name>A0A8J2H4V2_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS102</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030000615">
        <property type="protein sequence ID" value="CAG5071953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H4V2"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5071953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="96" mass="11121" checksum="1BE40A9428E9E4AB" modified="2022-05-25" version="1">MKKIDKFLALPSQQTRKLVNHQMTKISWYRNQKIVYYDTRPESWISWRMGYDGRGVAEAIISHTSGHPTFGSWVVYYFSCSPAESTQPRGRGFAEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H573</accession>
    <name>A0A8J2H573_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Similar to HOXB2: Homeobox protein Hox-B2 (Homo sapiens)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HICCMSTLAB_LOCUS1369</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001116">
        <property type="protein sequence ID" value="CAG5075215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H573"/>
    <dbReference type="OrthoDB" id="6159439at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020479">
        <property type="entry name" value="HD_metazoa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050848">
        <property type="entry name" value="Homeobox_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000047">
        <property type="entry name" value="HTH_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24333">
        <property type="entry name" value="HOMEO BOX HB9 LIKE A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24333:SF8">
        <property type="entry name" value="HOMEOBOX PROTEIN CEH-62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00024">
        <property type="entry name" value="HOMEOBOX"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00031">
        <property type="entry name" value="HTHREPRESSR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 5 6" id="KW-0371">Homeobox</keyword>
    <keyword evidence="4 5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="8">
        <location>
            <begin position="75"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="5">
        <location>
            <begin position="77"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="55"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAG5075215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="266" mass="30741" checksum="A38EC044FA846DCD" modified="2022-05-25" version="1">MSSSYVNLENEELFWHSFESLHPDVFSTLSSQLLLTPESISTEEPIIVQSHNSASDINTHQSVEKTEMLNKKTSNSKRRARTAFTNNQLLHMEQIYAQNKYLCLEERNNVAESLGLTEKQIKVWFQNRRTKDKKIGSKKRVQDSDHVLGSYLGVCDKTNMVVNHVQDSTYPTYNVQYNSVPAPIECPVKNHVRPTNSNNCSSESGNYPQFQDWNTYNQYQTNVIQYQNYGSNIYYNSNEKNVLSTFCELLKNSTRKAFDTSLTFQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H5M2</accession>
    <name>A0A8J2H5M2_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">protein O-GlcNAcase</fullName>
            <ecNumber evidence="6">3.2.1.169</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Beta-N-acetylhexosaminidase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Beta-hexosaminidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HICCMSTLAB_LOCUS1148</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>3-O-(N-acetyl-beta-D-glucosaminyl)-L-seryl-[protein] + H2O = N-acetyl-D-glucosamine + L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:48876"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:12251"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:90838"/>
            <dbReference type="ChEBI" id="CHEBI:506227"/>
            <dbReference type="EC" id="3.2.1.169"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>3-O-(N-acetyl-beta-D-glucosaminyl)-L-threonyl-[protein] + H2O = L-threonyl-[protein] + N-acetyl-D-glucosamine</text>
            <dbReference type="Rhea" id="RHEA:48892"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:12252"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:90840"/>
            <dbReference type="ChEBI" id="CHEBI:506227"/>
            <dbReference type="EC" id="3.2.1.169"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.169" evidence="6"/>
    <dbReference type="EMBL" id="CAJNRD030001116">
        <property type="protein sequence ID" value="CAG5074937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H5M2"/>
    <dbReference type="OrthoDB" id="9975416at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102571">
        <property type="term" value="F:[protein]-3-O-(N-acetyl-D-glucosaminyl)-L-serine/L-threonine O-N-acetyl-alpha-D-glucosaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016231">
        <property type="term" value="F:beta-N-acetylglucosaminidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009100">
        <property type="term" value="P:glycoprotein metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000009">
        <property type="entry name" value="O-GlcNAcase BT_4395"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.240">
        <property type="entry name" value="STAT, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051822">
        <property type="entry name" value="Glycosyl_Hydrolase_84"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011496">
        <property type="entry name" value="O-GlcNAcase_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13170">
        <property type="entry name" value="O-GLCNACASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13170:SF16">
        <property type="entry name" value="PROTEIN O-GLCNACASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07555">
        <property type="entry name" value="NAGidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52009">
        <property type="entry name" value="GH84"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GH84" evidence="9">
        <location>
            <begin position="17"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="452"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="472"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="506"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="526"/>
            <end position="537"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00030512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00050933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00052136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00066938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00076634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS52009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAG5074937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="924" mass="102105" checksum="8265EE8E188D8A4F" modified="2022-05-25" version="1">MTETNGTNNSNTKNGNFICGVVEGFYGRPWTSEQRKDLFQKMKKWGMDSYLYAPKDDYKHRAFWRDLYTVEEAEHLTGLITSARDSGITFYYALSPGLDITYSSVKEVTALKRKLEQVSQFGCTAFALLFDDIEPEMSEADKEVFQSFAHAQVSVTNDIFQHLGQPKFLLCPTQYCATRAMPNVPSSEYLNTLGSKLAQEIDIMWTGPKVISRLLTPESIEEITEVLRRPPVIWDNLHANDYDQKRVFLGPYSGRSPDLIPKLRGVLTNPNCEYGANFIAIHTLAQWSRCNVDGKRDLSLNDTVSADIKLETETEDGVVGEDVPSTLSPNMYHPRHALKAAIKDWLGEFSKKKAAWGVIAKPQPAVAPTVPIPIIPSVNTCMSLTATSTVSTVSIAPITAPGTTNHLAALAEVCSSVTSDFSGPTGPAMNSLVSDNKVEPVDTSIGTSNSVLGTVCSENGPGTGETAVMVGTSRTETQKIGTEDGTGSRNQQENLESPEVTEPMDCNTTPSNSPSQTVKDDEAMVENTSTCSGTSGSMQVEEVNGTQMIVETDGVDGEGEKDKDKMLTIEDLGLLCDLFYLPFEHGGQGIQVLQEFNWLKSNAHVVLKKKEESCKADYEEWLSRAAKFNDMGEAVNRLFQRMTYCDNRELLYDLYSYIWDMRGVISLLNSYIKWLGFSNGWKETFMSGDQEPWVFRGGLTADLQRLIPVDSGNDLFVYKAPEVPTSIIYTVRPYLPSDEDAVYALCNRITGVTGTSAVADRLVGGFLTISPEFCMVIEDDSGLVGYALTALNIKTHYKKMAVAWIPELKVKYPLEDITNDLPESVQEAIRYFHSFSPEVPEQLSQQFPSLVMCSLLPTVTDQSIAKRLITCSLAALRANGSFGIHTTISAMDKESHEFYGKLGFVDYNQGQEELPGVVTMSRSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H5U7</accession>
    <name>A0A8J2H5U7_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS2207</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001117">
        <property type="protein sequence ID" value="CAG5076512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H5U7"/>
    <dbReference type="OrthoDB" id="7449785at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5076512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="334" mass="38706" checksum="90A29CF16A3CF54B" modified="2022-05-25" version="1">MDPDFVRAILCSSGQFNETIKYEELDQLVEKVPAVDARTITALSKSLADSICYKISPEAHIKYSVRLQLIDILRDWLHPPLGLGDHRPFCQSENILELSKTIIIKYLQKKKLCDDNATPEQLITLIRSLMNIASINPIYAQYLKLIIKQITELEVAANYKLVQFILSNEKEINLEFSAVEDLIICQREKIIEEPIVDCFISNINSQDQFRTTESFDKLMKKTAYSPKIFQVVCSLLGKLCAQLQFSSFVLVFIQFILKTIVSLRDDEEKNLLNLYPINLQSHVILLRIEPRFSTENSNKYLLESLRKIYSEDKEQILILITHFPKWLDELVLFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H6D5</accession>
    <name>A0A8J2H6D5_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RNA-directed DNA polymerase from mobile element jockey</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS2782</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001117">
        <property type="protein sequence ID" value="CAG5078577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H6D5"/>
    <dbReference type="OrthoDB" id="7700357at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5078577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="181" mass="21079" checksum="97BFAFF5144AA322" modified="2022-05-25" version="1" fragment="single">MSAEIKDARNKAWTKKLEKLNPKGNSLWRMTKIFKTEFTSVPTLQKDNVEAVTDEQKANLIASRFEEVHNIDTINNTPEQNKITEKLYPLMVKGSPLYQHNKALIHKMLLRPIMLYAAPVWCSAAPTNIKLLQTYQNKCLRLILSANRYTRITELHNRTGIPYIKDYIEDLANKFYENQLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H6I0</accession>
    <name>A0A8J2H6I0_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS2779</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001117">
        <property type="protein sequence ID" value="CAG5078563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H6I0"/>
    <dbReference type="OrthoDB" id="10043418at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5078563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="241" mass="27101" checksum="21A653958D6A2835" modified="2022-05-25" version="1">MATTPRFDRCFNPYNLANHLKTRNLRKANDFIKKELNMYGDYVLCIDCKMKVYASAKHSKSVGDNVDNVDNNQNVDDDIACEVNVRSDDENSERQGDSCEGSCNLSLGHASQATALLKSFESLSFSSDNFQSQPIQSSSASEVSIETQLPVVNQALRLLNESPVLKKKLRDGVYLDRKVNQITRNLIKLFGLDDNGLSDLNVNLADFQDIIERLKAKFNDQNSSTAEKIRILTILPSRWSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H6J1</accession>
    <name>A0A8J2H6J1_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS2868</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001117">
        <property type="protein sequence ID" value="CAG5078880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H6J1"/>
    <dbReference type="OrthoDB" id="7553586at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="306"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="314"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="327"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5078880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="444" mass="47928" checksum="27207559385794D9" modified="2022-05-25" version="1">MIFVKLHVNNFSLKLSGKTSKFSSLSKFPVSITMDVQERSVDVALNHILRALNRVRHISSTGKLNDLSHVIREFSPLLPPLPAEDPAIDLLETIIQESSSSLSAHQSVESNPVSPKRSFWSKLFAKKSQDGASIASIGSGNDSSASSTALKAAEEQVAQLEASGPADLTSVSALSREINRKICVWSSGMSLRHEIGASRPGEPLNVQFHSQPEDIVGHWSLLGNLDPQEASSGLNDCLFNAIAAQTGLRPTELREVTVARMKTNIRSVARRIQDLARQESCDRIVLMVGGARYHGSTAKDAGRVLDKSQQGRGHPSHAHGHPRGHASNPSATGPTASAENYSHGSWKTAFLSVNDQDDVGNRALSTEPVRRAMEVLNAGGTRQVVTVNASELPGSLPQGAHFNDGQRGAIQDIKDLVLVLQHHAGHQSDPDYDVFVHTFYPRLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H6J5</accession>
    <name>A0A8J2H6J5_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS2768</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001117">
        <property type="protein sequence ID" value="CAG5078522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H6J5"/>
    <dbReference type="OrthoDB" id="6157789at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="237"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="237"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="252"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="744"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5078522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="744" mass="81223" checksum="66D0C2DB63439F8A" modified="2022-05-25" version="1" fragment="single">MSTVSKVMISVPRFFLVNRQLLFATMLFYLFVILFASALVQAAPTELTITDLKGVIEEVTTLRPSTVNETVYLDAKASQALGSPLESAGTSKNVSREIITGSPEASRATNITDTDTIIPVDTVTPVGEPIVSALKINAVGETIISTTEIPQASTTTSSITVVGMADELTTGAEITSTTFNSVEDDGVSALTLEFTTEAQVFSTATTPITDDIISTWTRETTTESLIDSTTSIKSAIDESTSTVTPEITKSAPTTETEISSTTTPTTNDEISTLTPEITTELFFILITPNELTSDGITTTLTPEIMTDPPTTESQISSTITPTVNNEISTLTPKITTQSFFISTTSSELTKDGITTTLTPEIITDPPTTESQISSTIAPTVNNEISTLTPKITTESLFISTTSSELTKDGITTTLTPEVTTESFFVSKTPIESTTDSTTTTLIPEMITDPPTTQTEISITTTPTTNDELSILTPETTTESFFVSTTPNELTKDSTSTTLTPEIITDAPTTDDKISTVIPERTTESFIASTTPFESITDGVFSTLTPESFPVPTTPIESTTDGITLTTTLTFETTTDAPTSAFLAINTTLNPATIGVISTSTVETSTTEETEVQTDENTTTAYIFYTSQFVLKHETPEYCNWYQINCNNYLNHQSFCTYLLVGDCNNFKAYQIWPIKQLVRSFTYFPYTFNYQYVYKEQRSYGCNLYRVKCEHYYFVNIKTEHCNHEYVGECSNYQMIHVINSSFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2025-06-18" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H6W7</accession>
    <name>A0A8J2H6W7_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to VPS13B: Vacuolar protein sorting-associated protein 13B (Homo sapiens)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS3012</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001117">
        <property type="protein sequence ID" value="CAG5079440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="445152at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026854">
        <property type="entry name" value="VPS13_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039782">
        <property type="entry name" value="VPS13B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12517:SF0">
        <property type="entry name" value="INTERMEMBRANE LIPID TRANSFER PROTEIN VPS13B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12517">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 13B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12624">
        <property type="entry name" value="VPS13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Chorein N-terminal" evidence="2">
        <location>
            <begin position="5"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5079440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="3708" mass="424546" checksum="6061DA99D7E72D4D" modified="2022-05-25" version="1">MFKIESYITPIILNYVGKFIKNFKPEQSQVSLWGGDATFQNLDLKLNVLNDELKLPFRFVSGHIHELSIHVPWVKIASEPIVVTINTIECILKMRDESEVNNDSNLQQKMNYETLQEETPSSYIKTIVTKVVNNITINCNNLILKFVEEDIVLSVNIRFFGVQTVNNEWKPSFTDINTTDMILRKLITIEDLTLCLDRMDASGKIEIYQDPVVYRCSMMIRWLINYQKAKSDLTERESITRFDIHCKKIEFSMTEHQLPMIMRLVTLILNSLQSELNSKDRMSLKSSDGIDQISVSSDDNLFVGNSNSSALVRPVNDISWGSWAWQTVTSIVPDWSNDLSLNKLLDNSIQVFDFGIYVDETVFTFKITEISQEVYSRKNIKVKYRPCISLQFSTMSASLLVYDINFTTIQIKLGGVGLYPQGNCTCGFSEVKNNVDPTFYLTAGSFQTDYCTSSLFDINAEENNGLTKNYKEIISKTLASKFFNDNFEKSPALIINFIHFIEIPEETPRKELFKFNRNFEFSNFKETKIMRYYIGNLNFKISSGIIHRISAIADLIESDFLACFNDRNNDLLIEPLSTTIEEFDALSEYVASEKLELIINQLTVQIFLANHNEIRKNNGDNIKNLKFLLDYPRLIFEIDKVELTTISPIYPLRVVLCACTQIQIPKEMLNSCYKTYELNVCNLKSKLYLSENNHMIFLTPFGCKLSAKSLIYPQYWSGHSDIIQASTDLTIENLTITATKVKFLIIYTIISSIFLKINTNIATFISLFHEACNETNQVYLELTIDRINYLNSQFLMFVSTKLNVGPVKIFVLNDITQAFIMSGPENQSENNKNQDLFYLFTQLPRYWDNEVDNLIIKFHFYKTRIILDPLLFDWLDYNCHFNDTNNLLLLFDNYAIDETSSDNSTRKKFPSLHENVHSLSERDYRFNAFNWIKDNYKNDNQKEPAVNNEKSQSSSSSVFTQIILNYYSQWRRLIFNITIDNCIIYQPTLTINCLGVDGIEEAKEQALSSNDALKLFVINTSKLNIQSASWNDQYCSEVNLYKILKINDAKLKNFPWTLDFMRFHCYTLINKKVNNFLNIDYFNATIDSTLKSDVGENHDNLNSLGFCIYINTSPILFSLTKKQLELVDDLLNINLKLINKILNTPSNTNNSSNFKFYNENLNFSVKNPLSPTQIFFMETDTISTSASTSKNDLEIDSINGDSITAWIQWTITKMIIELFTDDNDESINEEYNYKVMIEFEDIITSLDWQTIYIKLKNKITSAKILHYRKLLKEDDNCWKLGDFTGFIMSNKSENLDKTSNENDFLSFTLTKAKSNNVYHKWMRFKNKFSKNCIFNEDNAFAMSNYITEIVIEVQMLEIILPINLIQKFKSFFNYRLKKKESCNVENSDNHKFPLVYLDFKGITLIVPIDSPSNERYDTFVLTNDGISLIPHAENPICRMILRPDIYELAAQSNILNTPSSILEDRQYQIKINGISVSTTNWLNYHVKGTKKKTPLLFTMNENPALEWNELENTSIDNKSTICTLINRFDLCCIIAPSMILKSKIVVCGNAVEITCLTDIEIVINLDQIKLLNTLFYKLKQLEIKVNEEDSDKCKINTYYCPTTLPTVQETRNESIQESYRDSVKDSGVDVDSSSVDRRIYINTKDQRITEPYENVINCGKLSIAVYKNDKEDGDKSNLKVPLVFIAVYQPNIYISQHNRSRVVRINCFDISLLFSEKDSKVMSLPNVDCYQNVLLQTKNGDPHPTTGIPPSFLVIKWENNVEHCSISTDIGRPTKINVSSSLIDQINNLNYELVSILDWKKQEESESSSSFINDFLMIKNNSDVIDISLITNQIVVAVIIDLATEIINNISELSVTISSHIRKINASVDITSFMITTNIKGCLKALLNPLSCNFIAKIILESWQDFDESPLVRLRIYSNSISIDLGPEQVKFIEEVLNKFGHYFENYSSEDSGKQNLNQISSTEQYYQDDLRAGAFQFADGTNDQVPLPYQVIFSNYPQKIMAWKYPQPRILTRLNLTSILWNIIDDLDIELHKINCIIEYWNDNLMSYQRFIQFNMAESDNLTSLLNKSPTRAVSCLWRAVICSTDKTMDSITPRDLAGCLRIDSYFNSSCISTVEVTFNISYIKLSLFNNFNNHNYNILPSPIEKFKLNNFVPLNQRFADFTVENNCFIHNKWINGGSLSNFTGNLSIKTLDYESMTMYQVLKSLEFKAQLNKLSNTKLSLTVSEMTFRFGPEVAHTVILSLDLWNSILKNDSSLRNCSIFSKIILANDCNLPIRISQDKTTDDIILQSRECYFYSWRLKSNSKLRVAIKIDQTWVWSDLFKVNNNSDYNVIEINTNSKNKVKLHYKTKFIMSTQKVIFFTGQLVVKNELNEDFELKLIQYNSTDNNKILKSESIFTLSGNSPPQSFIINDISNVTMRLRFLNLTSVTSWTGDIPLNANPKCDQPWLVKLPLNNKNQFVCIWVRNIRENLSGDIKILVVLSPLYLLQSWLANPVDITIETPALNSSINSTLTGRGEIQQIHCPGTFEHIHSLKLIFSEENSNLSIPISYNSVDQRSFFKVSENEKIDDILTRLSENKNGKKDFWPSEFENYNWIPIAQSQSYIQIKYRDAGLISSTLLVEIRPWCFILNTYCKNLNLVSPEIDFMCEIPSNSITTPPKISAIFHIEIESSNRKFQSPPLQFGNSESNRGFIKPQINGLIPLEGSIEIFIDCGSTTACLIINSHTIDSTRIIKIMSSHVVCNLTSYSFKLASICVDKKCSSVDFTSNLTEIQLYLPPSKNDDIGLPIESWYNLGNINCEANNFNSYISLMLQESNDIYCWSCPIKIEQIFGRNSVSVINGSETIPIIITSQKDHDIIYITIIEDTFPQFTITNSCSFTVMIGHPNGTLDSLELESPPFNRICNIRPGNSCHYTLKKFGSWIPDSSIDKKISAQLWLCIPLEQKDQDFNRIDVDKLKNNSISMKLIEYPTDYPVKFDKFIYLDRYGPIKIIVSSWGHTIFINIEPKSNIEVSVRDIRSRLITENEKSSDNSKFSAVKNIKPSSVNNFNYNNDNLKLEDTESTHLSTENIANNSNLENLDTVFTLYLHKVNIIITQDDNNGISKEVAALYLTHTFITITSNAKSLNLKAIIGDLQLDNQLFNNGGYDFPVVLINQKPTNMNKMMVDLSNNSESSVLGLKDEFLFTLELSLDKIFNRNAFKNVYIKILPTNIYIEDKFISQLLDYISIIIQPYIFTSSDNLRIKMKKHLKDKLIKGVRIPTNVIMDTKIISSPLRLQNLTIEPVSILLSVHTSVRLYIALDHSPLHFAIFERHNLITTPYRLGNALTMHYLSGAIFGAGWVVGSLEILGSPGSFAQAVGLGLKDFISLPFQGLLHGPWGFIVGITHGSASLMKNVTAGTVNSVTKLASSVAKNLDRLTLDNEHLQRQEESRRLKPQGMTQGFYQGLTSFGISILAAVAGLAHHPLQNYLSNDSTTRGIVTGVGLGLVGVLTKPLSGAAELVALTGQGLLQGTGWNPLPSPKRHFEITSNDLHNMESRFLWKLMDYITENHDDILYLVNADFVDSNEKKPVVLILTRKKLIVINIENDNVQKMFSFNDFYCSEDNTKNSKLFRLVFSITSNTNKSKNHSYSDEQREISDEMRTRVEQYILSGRLHNYCHATGSNNPVVSSELNEHGDNSLLFVMDFHKKNYLMSIIKLIKRQIQQKDFTVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H803</accession>
    <name>A0A8J2H803_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS3298</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5081489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H803"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035167764" evidence="2">
        <location>
            <begin position="18"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5081489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="126" mass="14851" checksum="A18C908B26FE7CEB" modified="2022-05-25" version="1" fragment="single">LNTFAVILLGVVAVSFAAPGYDHHKHVVIHVPYKVHTVHHHHVKKVPYPVHHVEKVHVPVHHVEKVHVPVPYPVVKKEYVPVIEKVHVPVHIPEHHEHHEHHEHHIPEHHEESKWSFDDDKKGWWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H804</accession>
    <name>A0A8J2H804_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Olfactory receptor 84</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HICCMSTLAB_LOCUS3419</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5081947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H804"/>
    <dbReference type="OrthoDB" id="6617147at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005549">
        <property type="term" value="F:odorant binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004984">
        <property type="term" value="F:olfactory receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004117">
        <property type="entry name" value="7tm6_olfct_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21137">
        <property type="entry name" value="ODORANT RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21137:SF35">
        <property type="entry name" value="ODORANT RECEPTOR 19A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02949">
        <property type="entry name" value="7tm_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0552">Olfaction</keyword>
    <keyword evidence="8 11" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="9" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="38"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="129"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="194"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="266"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="297"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAG5081947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="394" mass="45877" checksum="AEB053A0A5C82670" modified="2022-05-25" version="1" fragment="single">MEKLSSDQKQLDEGVKIFDYSRRVSKAVGLWPLASNDYIFTFSYCYFTVILIFEWMDLYYSLDDLNSVLDNLTENLSFTQIYIRGIILRIHMNRLKEIIKNTIGDFSINSFKNPSEIKIFMTYIDKGRFFVKSIISFMAMTVITWYFQPLTTPAPVASDNETILFLLPYRCHIIFEINDSKSYMLTYITFAPHTWIDGCSHASIECLLITLVYYLRGRLIILAGRIDRLSGMETLEWKNDLQDIIVEHIRLLKLGNNVIDIYSTSLMVYMICTTTCICVIGYKILVNCMTGPDADLVQFFIYIFAVYLIMAVFCFISEQLMSECDKISEAFWNCEWYRMPPKTVVNVMFCIQRSQRPLTLKIGKFAHFGHNMLTVVTKTAMGYLSVLRNFLVIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H8A5</accession>
    <name>A0A8J2H8A5_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="13">ATP-binding cassette transporter subfamily C member 16</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HICCMSTLAB_LOCUS4063</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5084272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H8A5"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18580">
        <property type="entry name" value="ABC_6TM_ABCC_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03250">
        <property type="entry name" value="ABCC_MRP_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03244">
        <property type="entry name" value="ABCC_MRP_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000973">
        <property type="entry name" value="Multidrug resistance-associated protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000014">
        <property type="entry name" value="Multidrug resistance-associated protein member 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000163">
        <property type="entry name" value="Multidrug resistance-associated protein member 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044726">
        <property type="entry name" value="ABCC_6TM_D2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF415">
        <property type="entry name" value="FI20190P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="47"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="72"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="430"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="501"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="573"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="603"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="688"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="12">
        <location>
            <begin position="1"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="125"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="12">
        <location>
            <begin position="434"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="776"/>
            <end position="1005"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="374"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="385"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAG5084272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="1028" mass="114591" checksum="E81D98D4B8D6A444" modified="2022-05-25" version="1">MRFRVACSSLVYRKVLRLSKPVLDQTPVGQVINLLSNDVNRFDQLPVYINYLWISPLQVAVIGYLIWRSIGIYTLVGYGVLLLITVPMQGYVGVMTGKLRNLTAKLTDRRIQLMKNKANPGAVIVKLDKVSANWKFGQLPPTLCDVSLKIKGGELCTLVGPVGSGKSSLLNVLLQELPVGAGTVELFQFSDGETAEAQSKSGFSQDNPAMIISYASQDPWLFTGSVRENILFGQEYDKARYQEVAKVCFLLQDFKQLPEGDLTIVGERGASLSGGQRARINLARAIYRPADLYLLDDPLSAVDARVSRQLFQDCILGYLKGKTRILVTHQLNYLKQADSIIEIDRGTIKQQGSYQLLQDSEFLKLLENVKNETQSIEKPNGPIDENGRPLESHHTESATGSENTVADEVVGTGFISKAIYYRYFREGGGIAGVILLAALFIITQAVAVGVDQWMTYWTTLRADQHCNNNSSVSQDVNHQSNFLVNATNPFFDSKGFLLTDILVYIHLALLITFITLSMSRCYYLVKIGMRATRRFHDLMLTNVLQASMYFFNTNPSGRLLNRFSKDVGVIDEVLMPLMLQASLTIFNAAGTIVNIVVINPWMIILTVVAGLAFYLITICYLMTSQDAKRLEGITKSPIYTHVASTFNGLTTIRSRGESVQSMLRNEFDRYQDINSGAWYLLIGSGSAYGFSIDIIACFFIFVLCFSLILIDPSVGLAISQSLTLTNTLQWGIKQSMEVQSQMTAVERVIQYTDLPKEGPIESSKPLTENWPSKGRIQWKNVYLSYKKDDPAVLKNIDLMIEPGWKVGVVGRTGAGKSSLISALFRLVDDGLQGQIIIDGVDTKTIGLQDLRSSISIIPQEPVLFSEKLRYNLDPFGKYTDKEIWDALREVELSDLALDQWVTEGGTNFSVGQRQLICLARALLRNNRILVLDEATANIDSRTDALIQRAIRSKFADCTVITIAHRLNTIINSNRILVMDNGCAAEFDTPYELLIEKPDSIFAKMVKQTGPSMTAKIIYEVTKFYQELT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H8I8</accession>
    <name>A0A8J2H8I8_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS4132</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5084540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H8I8"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5084540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="204" mass="23634" checksum="BA73BD654F261FAC" modified="2022-05-25" version="1">MPSSRQGGLYDFIEQGMEQKFFNIVKNLFFHQREWEIDQQEEKEQEEEGDSQADFFGEEDSSTLSIHKTESASAHEEECFQSTYDEEEEDLLSLINLENLTPSQNSLITAVLRECEKEKILPIHLPEAEIPVITIDQDIPLITLDGEEDKNLFKEKSALSQKIDDAAKKFFAEIKLRKRKDITILDNNIVNNKFVMFGKKSKIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H8M2</accession>
    <name>A0A8J2H8M2_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS4268</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5085074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H8M2"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5085074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="175" mass="21736" checksum="3EFEA3DBB211C56F" modified="2022-05-25" version="1">MFWKEVKDTYGHPITRKMNKLLKLSNIKTKTICKTHFLKKCIKFNVLPKSSNFSFIKSRSKQYKKNIERFNECTWRYRQRLVNLDIDELYFKIDKLDFSMLRLNSEIRIVLTHRQHRIFKNIEISNNSNTDNRLRKHYINKIKELRYNKHFESRTYLFNNKENTKKERTKFEFIW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H8Q8</accession>
    <name>A0A8J2H8Q8_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Similar to Serine protease inhibitor I/II (Schistocerca gregaria)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HICCMSTLAB_LOCUS3466</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6 7">Belongs to the protease inhibitor I19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5082137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H8Q8"/>
    <dbReference type="OrthoDB" id="7655988at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004867">
        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008037">
        <property type="entry name" value="Pacifastin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036201">
        <property type="entry name" value="Pacifastin_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05375">
        <property type="entry name" value="Pacifastin_I"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57283">
        <property type="entry name" value="PMP inhibitors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51446">
        <property type="entry name" value="PACIFASTIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 7" id="KW-0646">Protease inhibitor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 7" id="KW-0722">Serine protease inhibitor</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035248830" evidence="8">
        <location>
            <begin position="20"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="Pacifastin" evidence="9">
        <location>
            <begin position="39"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="domain" description="Pacifastin" evidence="9">
        <location>
            <begin position="89"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="site" description="Reactive bond" evidence="7">
        <location>
            <begin position="118"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="42"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="92"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAG5082137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="126" mass="14050" checksum="33B21DFF06792463" modified="2022-05-25" version="1">MKKMMISFALMAFVAIAATENHYVMDPDGTEYLVVDKEPEHCEPGKKYMVDCNKCSCSSNGKDLACTRRKCPPHPVQQNVQWGPFWKHGDPCPANKEFYSECNRCQCGPDGKSAVCTLKACVRPAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H8X0</accession>
    <name>A0A8J2H8X0_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Similar to Hdlbp: Vigilin (Mus musculus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HICCMSTLAB_LOCUS4480</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5087306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H8X0"/>
    <dbReference type="OrthoDB" id="10027144at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd22405">
        <property type="entry name" value="KH-I_Vigilin_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22413">
        <property type="entry name" value="KH-I_Vigilin_rpt10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22414">
        <property type="entry name" value="KH-I_Vigilin_rpt11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22415">
        <property type="entry name" value="KH-I_Vigilin_rpt12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22416">
        <property type="entry name" value="KH-I_Vigilin_rpt13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22417">
        <property type="entry name" value="KH-I_Vigilin_rpt14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22418">
        <property type="entry name" value="KH-I_Vigilin_rpt15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22406">
        <property type="entry name" value="KH-I_Vigilin_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22407">
        <property type="entry name" value="KH-I_Vigilin_rpt3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22408">
        <property type="entry name" value="KH-I_Vigilin_rpt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22409">
        <property type="entry name" value="KH-I_Vigilin_rpt5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02394">
        <property type="entry name" value="KH-I_Vigilin_rpt6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22411">
        <property type="entry name" value="KH-I_Vigilin_rpt8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22412">
        <property type="entry name" value="KH-I_Vigilin_rpt9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.10:FF:000018">
        <property type="entry name" value="vigilin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057778">
        <property type="entry name" value="KH_Vigilin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10627:SF31">
        <property type="entry name" value="DODECA-SATELLITE-BINDING PROTEIN 1, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10627">
        <property type="entry name" value="SCP160"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00013">
        <property type="entry name" value="KH_1"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24668">
        <property type="entry name" value="KH_Vigilin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="15"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50084">
        <property type="entry name" value="KH_TYPE_1"/>
        <property type="match status" value="13"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="K Homology" evidence="8">
        <location>
            <begin position="49"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="8">
        <location>
            <begin position="124"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="8">
        <location>
            <begin position="196"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="8">
        <location>
            <begin position="268"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="8">
        <location>
            <begin position="337"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="8">
        <location>
            <begin position="408"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="8">
        <location>
            <begin position="479"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="8">
        <location>
            <begin position="553"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="8">
        <location>
            <begin position="625"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="8">
        <location>
            <begin position="699"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="8">
        <location>
            <begin position="772"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="8">
        <location>
            <begin position="845"/>
            <end position="945"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="8">
        <location>
            <begin position="946"/>
            <end position="1012"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="8">
        <location>
            <begin position="1024"/>
            <end position="1093"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="8">
        <location>
            <begin position="1094"/>
            <end position="1163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="894"/>
            <end position="914"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1176"/>
            <end position="1258"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="602"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="749"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="894"/>
            <end position="907"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1176"/>
            <end position="1187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAG5087306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="1258" mass="142237" checksum="EA8A43996662F917" modified="2022-05-25" version="1">MQQQLVMEEGTAYEPPTYDETFPELPGSCNHTTISNQLPVNNSMRVGSKTVTTVFHVPLEERKLDHSDKFGEGESMRTCQAIMKETNARIEISSSKSQTLSFVLSGVQSQVLEARRRILATFQTQASKQISIPKEHHRWILGKQRQRLNELEKNTATKINVPSVDVQSDIIVITGTKEGIEKAEHEIKVISDEQSRKAFERIVVPKIYHPFIRAFKDNTIGMNANTSLRINIPPASVQNDEITIAGEKESVVAAKKKIESIYRDVEQRYSSVSVEVPKSQHKYVMGPRNTTITEILQLTGVSVEMPSPDSSTGTITLRGPQEKLGQALDKVYEKANSVRTATVEAPSWIHKYIIGRKGSNIKKITEDLPKVNVDFAENDNKIKIEGPPEEVEKVREQVEAHAQDLINKLTFVELKVDPRYFKHIIGKNGSKVNRLKEETNVFINIFEKDGQNIIRIEGNQAGVTEAEAKLMKTVNKLENEKEKDVIIDHRHYASVIGKKGFNIKEIREKFNNVQITIPGPNEKDDVVKIRGPKLDVDRCHKYLMKLAKELDENSYSIEVPIYKQFHKFIIGRGGMNIRKIREETQTKIELPSEGSADEVIVITGKKENVEMARDMIKKIQNEMSNVVEEEVIIPPKYYNFLIGTGGKIIHSIMEDCGGVTIKFPTAESKSDKVIIRGVKEDVEKAKQQLLEQTNEKQLMSFSDTVRAKTIYHRFIIGRQGANIKKIKESTGARVVFPTDKDEDPEIITIIGKKEAVEKAKAELELAIKEIGNIIEDEITIDPKHHKYFVARRGGVLARIADECGGLQILFPRAGVDSDRVILKGSKECIEAAKQRMREIVHELESKITIECIIPQVHHRTVMGSKGSKVQMVTSEYDVQIKFPEREQINYDEQSLQEPQHEQQINGDKNQETEMNHGPPPCDIIRITGQPENVEKAKKALLDLVPITVQVDVPFDLHRLIIGKSGRDVRVLMSKYDVHINISPADQKKDYIEICGAPANIEEAKQAILERVEDLEAKRQERALKSYELKFQVSPEFHPKLIGRGGVVIKKIRTDFDVQVDFPKKGDPEENTITITGFEKNTHEAKEEILKIVNGLAKEEIKIDSAVHSRFIGARGKNIRRIMEDYKVEIKFPRKTDSDPDLVVIIGSEENVTDAREHLLNLEYEYLQDLEDRERTKSIRGGKHESDRPLGSNESDSGFVVKGGPWEQQQQSQQPRNAPDTASVADFPTFVGHDSNQVSVATPEGPWGKRRDVLANSLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H8Z4</accession>
    <name>A0A8J2H8Z4_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Similar to ANAPC1: Anaphase-promoting complex subunit 1 (Homo sapiens)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HICCMSTLAB_LOCUS4525</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the APC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5087485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="26401at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060090">
        <property type="term" value="F:molecular adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007091">
        <property type="term" value="P:metaphase/anaphase transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070979">
        <property type="term" value="P:protein K11-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024990">
        <property type="entry name" value="Apc1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048971">
        <property type="entry name" value="Apc1_3rd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041221">
        <property type="entry name" value="APC1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046794">
        <property type="entry name" value="Apc1_MidN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049255">
        <property type="entry name" value="Apc1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12827:SF3">
        <property type="entry name" value="ANAPHASE-PROMOTING COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12827">
        <property type="entry name" value="MEIOTIC CHECKPOINT REGULATOR TSG24 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12859">
        <property type="entry name" value="ANAPC1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21282">
        <property type="entry name" value="APC1_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18122">
        <property type="entry name" value="APC1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20518">
        <property type="entry name" value="Apc1_MidN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-0498">Mitosis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Anaphase-promoting complex subunit 1 N-terminal" evidence="7">
        <location>
            <begin position="63"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="domain" description="Anaphase-promoting complex subunit 1 N-terminal" evidence="7">
        <location>
            <begin position="561"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="domain" description="Anaphase-promoting complex subunit 1 middle" evidence="9">
        <location>
            <begin position="654"/>
            <end position="977"/>
        </location>
    </feature>
    <feature type="domain" description="Anaphase-promoting complex subunit 1 beta-sandwich" evidence="10">
        <location>
            <begin position="1604"/>
            <end position="1689"/>
        </location>
    </feature>
    <feature type="domain" description="Anaphase-promoting complex subunit 1 C-terminal" evidence="8">
        <location>
            <begin position="1723"/>
            <end position="1923"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="296"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="296"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="318"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF12859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF18122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF20518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF21282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAG5087485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="1950" mass="218393" checksum="9E183914B87BA249" modified="2022-05-25" version="1">MIAASDPLEYTPGGRQTYQRHPGPVIHHLNSQSPPTQDSVLLQKFSQVNISEKSPKEFWIVRENKTCGEEELYCSGKVAVHTQGSPSTRVLQKSFCLESDIKHALWCRFCTTTPNLVDKDKNKNEDEVKDDQTIECICLLDTHTLRVFTPDGEDYMTSLQFKVSAVWPTKFGILMEKSSVKSSINEESLPTAYSLTHPLDEICPLLIKHGGVSYMRDTNLKIIFTSSEPSLAVIYDTKTGLHSVYKIRKSSVEERQVVYDVTASMMSIASPLHGNKSNPKSVSMFGLPNPQLSGLGMSSSPFGSRGTSYTTSCSGGVSPAQAHQSAHSRSQSPMATISRCQSPTHTFSPLAGGSMHQNRLHQTVMASMLCHSQHNPSGCNSFMLSEAPMVSSKPLYPEICLDHVWTEAAFKEVDRAADKASKVFLTTDLVGQSYLGYLVPSKTQLFIVRMEKTNKQQQIIFGMSTSIIAKDAVSLSSLNMIAIIDSSNGVTLYSGVTCIGKVHITSTPSIGCNYFLTPRTSVSSPFPRRSSMISQNTAADVKFEEALHTLSPVGACVRPPMLDSVDAGLVGLKDAVGNQLTLEYGNKVFYRITLPKFSSSPLVRECLQVLKTVLQRELAMQLLVKWYGARNAPGPQDFTIEEEWQLFIVTLLTLMGYDVDKLQLIRKNDDDCSGSSPIALVAAPKKAKTSDCGSDEDWLYILNSGEHKQCQFFLENVLHLVKFNEGAEELGKTKAEKKPEVGRITSSAVLFPHMPVVLFSLHLLYEELKLNCVMAESRPLLAQLLNHLSRDLKFNWYSYHYLLDYPTHCSKQELSQMTQQDLAKISVPNYVPEKPPSIFSTLNSLLKGSEVSPYPILARVNPRTKTIISLIALLAAESKVNSLNLDQLVKTVTPAGSRVDYQDPVKDKDKEFNRIESPDADRIVLLFHEMELTKKDLEILPPGISILLKDIMYRCRERPPSNWPVEAYELVDRQDLAALVKHSSFNKADDETTGVCPIRDPEQDDGMSFDDTILKLRFNKDHRVTELRRMLNSSKPVRISITQRPEVTDHDFIEEQERYLCAVCSRTMALPVARGMFTLRTSTPIITEQLPIPRLCLTGKTALRGTTIELCHIDVPPNMNLWPLFHNGVAAGLRIHPDALDIDSTWIVYNKHQQNECGIEHSGFLMALGLNGHLKKLAPISTYEYLVECHETTNVGLLLGLSATHRGTMDVSMTKLLSLHVETLLPPTSIELNVQQNVHVAALMGVGLVYEGTGHRHISHALLSEIGRPPGPEMKNCVDRESYSLAAGLALGLVVLGRGGGADLSSIPDTLHYYMVGGNVRPFTGAQKEKYKSPSYQIREGDSINTDVTSPGATIALGLMYFNSKNRAVAEWMRAPDTQYLLDFVRPDLLMLRILAHSLILWDEIEPTKAWVSSHVPDIVYKYRLQKPTPEITQHVDLETMNQAYCNIIAGACMALGLKFAGTANENAFKTLFNYTQMFTALSHKSIGELAGKSTIETCLNVTLLSSAVVMAGTGNLDIMRICRQIRTRVGPASSVVTYGSHLATHMALGLTFLGGGRYTLSNSPNAVAALIISLFPKFPTHSNDNRYHLQALRHLYVLAAQPRLILPRDIDNKQYCYATVKLTFKSDKFTRGQEVILKAPCLLPQLESLQKVELKDERYWEIIFERGHNWKLLEGMLNKCDSLDVKQKTGCLSYIEDPHGFRSLVAQTLTTENVIPWATKQDLITSFTNDETVLNIVKYFLQPTAEPNPRKKRVRRRPKKELDCSAEKMDFSDTSIVKIREQDSILNLGIYKDFRLKEKHFMQTLAVIVYECVIKDKISFMPLWINIYKSIEAIEKTPDAGLVWQIKLLSSYTMLKAQQQTQPLLRIESVLAIHQRLALIVDSWEDEVKPLIESYRINGTIDKQNDTTLRKFSAYCTYFDIPYRLIYNSDINQTIKNLLQRIQRFPSIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H925</accession>
    <name>A0A8J2H925_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to UBQLN2: Ubiquilin-2 (Homo sapiens)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS3848</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5083470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H925"/>
    <dbReference type="OrthoDB" id="9450922at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031593">
        <property type="term" value="F:polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14399">
        <property type="entry name" value="UBA_PLICs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.10:FF:000077">
        <property type="entry name" value="Ubiquilin like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015496">
        <property type="entry name" value="Ubiquilin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10677:SF3">
        <property type="entry name" value="FI07626P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10677">
        <property type="entry name" value="UBIQUILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00627">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00165">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50030">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UBA" evidence="2">
        <location>
            <begin position="77"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5083470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="127" mass="12996" checksum="68F95F66F178781B" modified="2022-05-25" version="1">MSQTGTTGTGTTAPETGTGTGTGTTTASTPGTQDAFASPQNAFSNLLAHVVSSMSLHQQENVDGQGGVGVGGQNLPPPEERYRTQLEQLTAMGFVNREANIQALIATFGDINAAVERLLANGQVSMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H965</accession>
    <name>A0A8J2H965_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS4630</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5087868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H965"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5087868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="96" mass="10981" checksum="2E1EC0C7E2BE24AB" modified="2022-05-25" version="1" fragment="single">INVTHLIIDRLLTVHSGHCHLFSVEHHGHGFGCLFAAGGLCLRICRSENLRAVAYRIRPLLPKHWTGFESDCIILLSPRNINEFQSQKFTPYRSRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H9K3</accession>
    <name>A0A8J2H9K3_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Similar to CDC5L: Cell division cycle 5-like protein (Homo sapiens)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">HICCMSTLAB_LOCUS5032</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CEF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5088936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H9K3"/>
    <dbReference type="OrthoDB" id="1410009at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11659">
        <property type="entry name" value="SANT_CDC5_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000021">
        <property type="entry name" value="CDC5 cell division cycle 5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000091">
        <property type="entry name" value="CDC5 cell division cycle 5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047242">
        <property type="entry name" value="CDC5L/Cef1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021786">
        <property type="entry name" value="Cdc5p/Cef1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017930">
        <property type="entry name" value="Myb_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047240">
        <property type="entry name" value="SANT_CDC5L_II"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45885">
        <property type="entry name" value="CELL DIVISION CYCLE 5-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45885:SF1">
        <property type="entry name" value="CELL DIVISION CYCLE 5-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11831">
        <property type="entry name" value="Myb_Cef"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13921">
        <property type="entry name" value="Myb_DNA-bind_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51294">
        <property type="entry name" value="HTH_MYB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="17" id="KW-0132">Cell division</keyword>
    <keyword evidence="7 13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="9" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="HTH myb-type" evidence="16">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="15">
        <location>
            <begin position="3"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="15">
        <location>
            <begin position="55"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="HTH myb-type" evidence="16">
        <location>
            <begin position="59"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="111"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="247"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="404"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="480"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="756"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="111"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="247"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="414"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010506"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CAG5088936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="788" mass="89954" checksum="7146281325DAA7B3" modified="2022-05-25" version="1">MPRIMIKGGIWRNTEDEILKAAVMKYGKNQWSRIASLLHRKSAKQCKARWFEWLDPSIKKTEWSREEDEKLLHLAKLMPTQWRTIAPIIGRTAAQCLERFESLLDQAQKKEDNEDIDDLRKLKPGEIDPNPETKPARPDPKDMDEDELEMLSEARARLANTQGKKAKRKAREKQLEEARRLAALQKRRELRAAGITVSQKNKRKRGINYNSEIPFEKRPALGFYDTANEHVDPLAADFSRMRQQHLDGDLRSEKEELERRKDKQKLKQRKENDIPMGILNNEEPPRKRSKLVLPEPQISDQELQQVVKLGRASEIGREIASESGIEASESLLADYSLTPNVPVTPRTPAVTDRVLQETQNVMALTHVDTPLKGGLNTPLHNVDFNSIVPSSSAVATPNTILATPFRSQHGDGTPLSNTFSTPGSTRTLSGKNISATPIRDKLNIITNEDLEASESSGLRKRIKQQMQADFSTLPSAKNDYQIVVSDNEAMEEEADKSERNIVEDQADIDARKQQDLMEQQKRELEKRSQVIQKGLPRPVEVNLNILRSSTEGSLTDFQRAEELIKREMVTMMMFDAVQNPVQQSNKRNTALSQAQSYLDHNPYEDFEKTDLENARKLLDDEMAVVREGMAHGDLSLDAYTTVWEECLSQILYLETQKRYTRANLASKKDRVESLEKKLEDNRTHMTGEAKKAAKLEKKLKILTGGYQTRAQVLSKQLNDLLDQIQQAQLELSTFQFLKTQEEAAIPRRIESLMSDVNKQIAREKNLQVNFANLQDELQKLVVNSEKSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H9M1</accession>
    <name>A0A8J2H9M1_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS4696</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5088054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H9M1"/>
    <dbReference type="OrthoDB" id="7700249at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5088054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="110" mass="12500" checksum="248F258736A21FFB" modified="2022-05-25" version="1">MQEEISCEKFDMGNNLHDSANKYDVIIEKQKSVSVESFQNGILVTFLMYYVFALEYPKSIEGTLETIQRLFLEICPQEGTKRASKTKKATAIHPKVLSLTDNIGIYTDSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HA15</accession>
    <name>A0A8J2HA15_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Septin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HICCMSTLAB_LOCUS4452</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7 8">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5087221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HA15"/>
    <dbReference type="OrthoDB" id="416553at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01850">
        <property type="entry name" value="CDC_Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000064">
        <property type="entry name" value="Septin 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030379">
        <property type="entry name" value="G_SEPTIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016491">
        <property type="entry name" value="Septin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18884">
        <property type="entry name" value="SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00735">
        <property type="entry name" value="Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006698">
        <property type="entry name" value="Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51719">
        <property type="entry name" value="G_SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Septin-type G" evidence="9">
        <location>
            <begin position="24"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR006698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAG5087221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="390" mass="44934" checksum="2FF08922AE21D510" modified="2022-05-25" version="1">MSGDRDYIGFATLPEQVHRKSVKRGFEFTLMVCGETGLGKSTLINSLFLGDLYKDRRIPDAIDRIEKTTTIEKKTMDIEERGVRLRLNIIDTPGFGDAVNCEDTWKPCSAYIDEQFRQYFTDESGLNRKNIQDNRVHCCLYFIPPYGHGLRQMDLEVLKRLHRKVNIVPVIAKADTLTSQEVRKLKENILADIEEHEIQIYQFPDCDSDEDEEFKQQDKELKACVPFAVIGSSTVLEVSGRKVRGRQYPWGVVEVENPKHSDFVKLRTMLISTHMQDLKDVTQDVHYENFRAQCISQISQQAIRERRYLPNKLKRDSGPHFENSISDTDRLLLQKDEEIRRMQDILAQMQEKLKATGQVSSGGLRGRVGSLGNDLDVIDHDKKRNSIIDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HAD2</accession>
    <name>A0A8J2HAD2_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Similar to pk: Protein prickle (Anopheles gambiae)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HICCMSTLAB_LOCUS5119</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the prickle / espinas / testin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5089138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HAD2"/>
    <dbReference type="OrthoDB" id="10069167at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030182">
        <property type="term" value="P:neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd09415">
        <property type="entry name" value="LIM1_Prickle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09418">
        <property type="entry name" value="LIM2_Prickle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09420">
        <property type="entry name" value="LIM3_Prickle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09827">
        <property type="entry name" value="PET_Prickle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000022">
        <property type="entry name" value="prickle-like protein 2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000035">
        <property type="entry name" value="prickle-like protein 2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000005">
        <property type="entry name" value="Testin isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033725">
        <property type="entry name" value="LIM1_prickle"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033726">
        <property type="entry name" value="LIM2_prickle"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033727">
        <property type="entry name" value="LIM3_prickle"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010442">
        <property type="entry name" value="PET_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033723">
        <property type="entry name" value="PET_prickle"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047120">
        <property type="entry name" value="Pk/Esn/Tes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24211">
        <property type="entry name" value="LIM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24211:SF20">
        <property type="entry name" value="PROTEIN ESPINAS-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06297">
        <property type="entry name" value="PET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00478">
        <property type="entry name" value="LIM_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51303">
        <property type="entry name" value="PET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0440">LIM domain</keyword>
    <keyword evidence="2 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="PET" evidence="9">
        <location>
            <begin position="233"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="domain" description="LIM zinc-binding" evidence="8">
        <location>
            <begin position="342"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="domain" description="LIM zinc-binding" evidence="8">
        <location>
            <begin position="407"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="200"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="530"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="674"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="758"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="815"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="562"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="579"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="703"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="758"/>
            <end position="786"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAG5089138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="834" mass="91492" checksum="C02BBC51D1B42C9B" modified="2022-05-25" version="1">MSSLARRRQTSLLFGSKRWWATGCWATRAHQEAYLRKLYGRKNSQANVNPALDLQEPGSWISSARPNSDGNSAPGCCLEDIIRGEDSGVGGGGTEISGASVLASPRASPTEKCVQFLTGARVCVPHDYLSDSLNHEQRQNPRVVSRCTEFNDYHGNGVVNCGYQDEKVCRSCRCPREDHHRTSIKSTDSSMAMAMAFQNTSTSSPSGGGIPPHQEPFKSPIEAPPALQDPLIHHHQRLSQSDDDSGCALEEYTWVPPGLRPDQVHLYFSSLPEEKIPYVGSAGERERVKQLLQQLPPHDNEARYCSGLSEEEKRELRVFAAQRKREALGRGHASQVERPHGTDCRECNRAITAGEMAIGASRAGPTALWHPACFICCICKQLLVDLIYFWREGRLYCGRHHAETLKPRCCACDEIILADECTEAEGRAWHMRHFACLECDRQLGGQRYVMREGRPYCLHCFDASFAEYCDSCGEPIGVDQGQMSHEGQHWHATEACFCCATCRTSLLGRPFLPRRGAIYCSIACSKGEPPTTPSDSSAGPPIAPPPPSFPKQNRKLPPPTPSEGSSSPPLSTTRHHTIAHTSGSARNSPRVSRKHYQGSTSLATTPTQISTFDFTCESLPNAGSRSAGLDRVILERNLERLLQERNTHTEETNPSELGRLMQARDREPLRCIQNSTPTHASSMPELPPPPHLLTQHSTTISPQTPPPPSPPPLPHLIPNISTDSTDLCGNPAPITDPPTPTSRRVRFEGDEAQALSTSTMPLTNNPCSSSSPSKLHVPRSSSSSDEATAYALPPRRAYGGVRISYVPNDAVACAKRRGQNLSQSQKEADKCILS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HBB5</accession>
    <name>A0A8J2HBB5_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Probable ATP-dependent RNA helicase DDX23</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">DEAD box protein 23</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">HICCMSTLAB_LOCUS6240</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Involved in pre-mRNA splicing and its phosphorylated form (by SRPK2) is required for spliceosomal B complex formation. Independently of its spliceosome formation function, required for the suppression of incorrect R-loops formed during transcription; R-loops are composed of a DNA:RNA hybrid and the associated non-template single-stranded DNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="13">The phosphorylated form (by SRPK2) is a component of the U4/U6-U5 tri-snRNP complex composed of the U4, U6 and U5 snRNAs and at least PRPF3, PRPF4, PRPF6, PRPF8, PRPF31, SNRNP200, TXNL4A, WDR57, SNRNP40, DDX23, CD2BP2, PPIH, SNU13, EFTUD2, SART1 and USP39. Identified in the spliceosome C complex. Interacts with ERBB4. Interacts with ERCC6.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the DEAD box helicase family. DDX23/PRP28 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="23">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5092586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HBB5"/>
    <dbReference type="OrthoDB" id="196131at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd17945">
        <property type="entry name" value="DEADc_DDX23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000322">
        <property type="entry name" value="probable ATP-dependent RNA helicase DDX23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000520">
        <property type="entry name" value="probable ATP-dependent RNA helicase DDX23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057479">
        <property type="entry name" value="PRP28/DDX23-like_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25430">
        <property type="entry name" value="DDX23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="18" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 17 23" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 17" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="4 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="22">
        <location>
            <begin position="369"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="20">
        <location>
            <begin position="400"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="21">
        <location>
            <begin position="631"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="18">
        <location>
            <begin position="299"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="16">
        <location>
            <begin position="369"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="19">
        <location>
            <begin position="22"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="46"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="107"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="125"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00037954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00055288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00062365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00072905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00075448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="CAG5092586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="797" mass="92997" checksum="6895C12F65356F35" modified="2022-05-25" version="1">MVGHESKKLRRSRSRERTHDRRERRRSRSRSKDRKKDASRKRSRSRERDRSRDRDRSRERDRDRERNHERGRSRERREVTNKDKDKDKDNKSHDKPRKPSPIFVIDDEPKKDSAEGQDKEDDEEDKKSKREPLSLEELLAKKKAEEEARAKPKFLTKEERTALALKKRQEEVENLRKQQLEDRKNSADVGSSKDSRDWDDRDNSRRRDSQRREEENKDKDKEKEVEAIKERYLGLIKKKRRVRRLNDRKFVFDWDTSEDTSVDYNNIYKERHQVQFFGRGNIAGIDIKAQKRDQSKFYGELLEKRRTEAEKEQEKMRLKKVKRKEEKQKWDDRHWSEKALNEMTERDWRIFREDYNITIKGGRIPDPIRSWKESGFPKEILDIIDKVGYKDLTPIQRQAIPIGLQNRDIIGVAETGSGKTLAFLIPLLLWITSLPKIERLEEADQGPYSIILAPTRELAQQIEEETNKFGQPLGIRTVVVVGGLSREEQGFRLRMGCEIVIATPGRLIDVLENRYLVLNQCTYIVLDEADRMIDMGFEPDVQKILEYMPVTNLKPDNEDAENEEKLLANYNTKKKYRQTVMFTATMPPAVERLARTYLRRPAVVYIGSVGKPTERTEQIVHIMGEADKRRKLMEILNRGVEPPVIIFVNQKKGADVLARGLEKIGFNACTLHGGKGQEQREYALASLKGGSKDILVATDVAGRGIDIKDVSMVINYDMAKTIEDYTHRIGRTGRAGKAGLAISFCTKDDSHLFYDLKQTILGSPISTCPPELLNHPEAQHKPGTVVTKKRREEKIFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HBW7</accession>
    <name>A0A8J2HBW7_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Similar to CIDEB: Cell death activator CIDE-B (Homo sapiens)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HICCMSTLAB_LOCUS5251</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5089471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HBW7"/>
    <dbReference type="OrthoDB" id="6475906at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042981">
        <property type="term" value="P:regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01615">
        <property type="entry name" value="CIDE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003508">
        <property type="entry name" value="CIDE-N_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12306">
        <property type="entry name" value="CELL DEATH ACTIVATOR CIDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12306:SF22">
        <property type="entry name" value="DNAATION FACTOR-RELATED PROTEIN 2, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02017">
        <property type="entry name" value="CIDE-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00266">
        <property type="entry name" value="CAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54277">
        <property type="entry name" value="CAD &amp; PB1 domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51135">
        <property type="entry name" value="CIDE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CIDE-N" evidence="4">
        <location>
            <begin position="8"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="176"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="352"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="524"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="176"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="193"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="401"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="531"/>
            <end position="547"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAG5089471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="547" mass="61126" checksum="7EE3BA3A6AADE881" modified="2022-05-25" version="1">MAREELRNKRPFKIWDSWRNVRKGLVVSNFEELLHRGKEKLGVPPNENVSLVLESDGTQVEDGEYLKTLANNTILLLLRHGERWCPTGVDIIRAGTATTLAPCYQDIKSNGLMNDTRNKKKNLAKNHYLSLSTAISAIPKIVCETIHALELHDETPSWKIMDNKGRVTVVLHWDQRSGSGSQGTQQPGGGQQAKSTDPSSSKYSPTKKADLGGPNQRPSLVIQTSLDKLGYDKGHPELVPPRYASPQITVINHDDMVQKSFTSPSSYGTAPGAAGAHSHSGMTGRLVKQGTNSFESSSTIHIHTPECSNRIHQPVTRNGSPVNGTDGNNTSECDFHCCALHEEGRRIAVHKSVATSPIQDQHAVQRDQHQQQTQTQTPSPQPPSSLSDGTRRTGMVKGHVRFRDTAEEDSPRNSGFHMHHNNHQEHDSSESETENTIMEDEIVTSEKFLLLIDQLTVDQKHHLSIKDIGIILERLSSKILDVERLDRESESEECYNWTIKAIIRGDVLRELGVIYNGNYYAISEHPGYKEESEENNEDNEEEEEDRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HBY4</accession>
    <name>A0A8J2HBY4_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Similar to mettl14: N6-adenosine-methyltransferase non-catalytic subunit (Danio rerio)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS6844</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5093454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HBY4"/>
    <dbReference type="OrthoDB" id="14833at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036396">
        <property type="term" value="C:RNA N6-methyladenosine methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045123">
        <property type="entry name" value="METTL14-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13107">
        <property type="entry name" value="N6-ADENOSINE-METHYLTRANSFERASE NON-CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13107:SF0">
        <property type="entry name" value="N6-ADENOSINE-METHYLTRANSFERASE NON-CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5093454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="149" mass="16596" checksum="434F9304E9A01EDB" modified="2022-05-25" version="1">MELNIEEISANHSFVLLWCKSTDGSERRSINGDFIHANVDIDSIISEESEYGSIEKPVKILFVGKGSTIRPDWLIVGSQLTNINFNTDIYSGYFASNQTTTSCTEKIEALRPKSPPSKDKVTERGRCAFNCRSRGKKRLNSGASMSIQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HC18</accession>
    <name>A0A8J2HC18_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">thioredoxin-dependent peroxiredoxin</fullName>
            <ecNumber evidence="2">1.11.1.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HICCMSTLAB_LOCUS4518</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a hydroperoxide + [thioredoxin]-dithiol = an alcohol + [thioredoxin]-disulfide + H2O</text>
            <dbReference type="Rhea" id="RHEA:62620"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:35924"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="EC" id="1.11.1.24"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peroxiredoxin family. AhpC/Prx1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.24" evidence="2"/>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5087457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HC18"/>
    <dbReference type="OrthoDB" id="2996783at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008379">
        <property type="term" value="F:thioredoxin peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033554">
        <property type="term" value="P:cellular response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1020.10:FF:000001">
        <property type="entry name" value="1-Cys peroxiredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1020.10">
        <property type="entry name" value="Antioxidant, Horf6, Chain A, domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050217">
        <property type="entry name" value="Peroxiredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024706">
        <property type="entry name" value="Peroxiredoxin_AhpC-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019479">
        <property type="entry name" value="Peroxiredoxin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10681">
        <property type="entry name" value="THIOREDOXIN PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10681:SF128">
        <property type="entry name" value="THIOREDOXIN-DEPENDENT PEROXIDE REDUCTASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10417">
        <property type="entry name" value="1-cysPrx_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000239">
        <property type="entry name" value="AHPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="5 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3 7" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="7" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="9">
        <location>
            <begin position="1"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="active site" description="Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity" evidence="8">
        <location>
            <position position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR000239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000239-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAG5087457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="196" mass="22262" checksum="CEBD99526EBA8A0C" modified="2022-05-25" version="1">MRLNQVIPNFQADSTKGPIDFYEWQGDSWVVIFSHPADFTPVCTTELGRIAVHYPHFKKRNVKLLAHSVDKLTDHVDWVNVTVKLDMIDEESKDDPENAITVRALYIVSPDHRLRLSMHYPTSTGRNVDEILRVIDSLQLVDRKPQIATPANWTPGEKVMILPTVDDNELPSLFPGGVDKVFMPSGKVYVCTTTDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HC89</accession>
    <name>A0A8J2HC89_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS6634</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5093163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HC89"/>
    <dbReference type="OrthoDB" id="5912242at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5093163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="204" mass="23315" checksum="9EFFEE6BBEB15EBE" modified="2022-05-25" version="1">MSIFHPTISFIGKNKEQNCAHVNFWCNSSLLQPCCDANNRCIQYSIGISECVIEEPQEFKSELINSSCTFDRDCRRLLHAECSEDEQCVCKPKNAYRNNKCLPILGEFCTHNHQSCATAYSECINFKCQCKNGYSQRSDNQCMLNIIGENCDDDEFCSQEISEDYYQKLILFYSNQHEYPVDVAGVLTTIAFDPALVSRQSESI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HD59</accession>
    <name>A0A8J2HD59_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Similar to SNX29: Sorting nexin-29 (Bos taurus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HICCMSTLAB_LOCUS5181</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5089299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HD59"/>
    <dbReference type="OrthoDB" id="93876at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07277">
        <property type="entry name" value="PX_RUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17689">
        <property type="entry name" value="RUN_SNX29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.900">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004012">
        <property type="entry name" value="Run_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037213">
        <property type="entry name" value="Run_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047329">
        <property type="entry name" value="RUN_SNX29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037916">
        <property type="entry name" value="SNX29_PX"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47194:SF3">
        <property type="entry name" value="SORTING NEXIN 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47194">
        <property type="entry name" value="SORTING NEXIN-29-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02759">
        <property type="entry name" value="RUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00593">
        <property type="entry name" value="RUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140741">
        <property type="entry name" value="RUN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50826">
        <property type="entry name" value="RUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RUN" evidence="4">
        <location>
            <begin position="59"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="PX" evidence="3">
        <location>
            <begin position="534"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="305"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="654"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="397"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="663"/>
            <end position="674"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAG5089299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="674" mass="76834" checksum="DE7FC33752BDDF78" modified="2022-05-25" version="1">MSLLSTALRMMSAIVPGSQSTESTVEANNPVDRFKLQEDLLSAAKACHVRFGGRMELATETDQCVYKLCYAFESIFRHGLRSKSVDKLNSALRHVSDLVTGSSSKTDLAFWPAIKEQLTWHEQERFSVLRNIHSDYGRGRAWLRAALNERSLERHLQSIINSNLSPFYEDWAFILDQERSSVLPTVAAGLGTIVFAIRVDNEELDDRQIDRCRASQSEPIISSGEPATRERVRRKVPMHIISFDNDEEERGVIDSASKSISAPPTCLNSPLGVPEVPAVLAEASAPSSNFLDPEQELQVNKADVPEPDVAWGPNESPEEERVLTPLTDGSMGGLVPVSPLDQTLEDMLVTLPNYLDTELTENAVEATEPLGLDSHIDASELDTEALRVRLIAMGEVLEQAKEDAVTSRLQLARFQRQHQNYLERHEVQLQALNRENELLRQQLRKYVTAVQMLRRDSDATVGDDEQARDYHYEAEQYQEKLVQVAEMHAELMEFNARLTMQLTNRDNLVKRLQAELECLRGPLNEEDMSLDQPCFINIWIPSAFLTGQASDVHHVYQIYVRIRDIEWNIYRRYAQFYALYRELKKHDAVVTTFEFPPKKTLGNKDAKFVEERRQKLQQWLRRVVGRLAQCSPAFTIRPTRQTLVSLMPFFGDQTNNEERKSRNNLSSSPQYMGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HD92</accession>
    <name>A0A8J2HD92_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BUD13 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HICCMSTLAB_LOCUS7101</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CWC26 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5093775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HD92"/>
    <dbReference type="OrthoDB" id="6022at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070274">
        <property type="term" value="C:RES complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005684">
        <property type="term" value="C:U2-type spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018609">
        <property type="entry name" value="Bud13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051112">
        <property type="entry name" value="CWC26_splicing_factor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31809">
        <property type="entry name" value="BUD13 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31809:SF0">
        <property type="entry name" value="BUD13 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09736">
        <property type="entry name" value="Bud13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="121"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="394"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="151"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="168"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="194"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="273"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="305"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG5093775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="454" mass="52511" checksum="7D518E10803C6FE8" modified="2022-05-25" version="1">MESKKLSQKEYLKKYLSGGDKKKKIKKKKIKNPTVQIIDDDINLDNIRPMDDAEFDIINATEDAPIIVGVIDERGPVDFADRKKWKIIADDGEGNVTVNSTQNNIDNNNFNQLSAYSESEFNSKNERRLKFKRHSSDLSPPRISEKRKNSSKSSQRVSSDSDLSPPRASKKSRDKKNKHQNSRYNSDMDLSPPRKSKHHSRELRKTRRDSDSDLSPPRKSKHHSRESSKSHNGRKRSRWASNSDRSPDRSPETNGRLKKTLDGKTAGLQNADALREETEAHRQREKEMFNSLSAEVSGFGQAAVMRDRKTGKRRDLAAEELERLEKEKRQKEIDDKYAKWGRGLKQVDDRAEKLKQDLYEMSKPLARYADDADLDAHLRSIQHEFEDPLRQFAKDKKPKPIYQNASMPNRFGIKPGHRWDGVDRSNGYEKKWFEAKNARAAIQEEAYKWSTSDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HDP4</accession>
    <name>A0A8J2HDP4_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Choline transporter-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HICCMSTLAB_LOCUS8007</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Choline transporter.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the CTL (choline transporter-like) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5096033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HDP4"/>
    <dbReference type="OrthoDB" id="420519at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007603">
        <property type="entry name" value="Choline_transptr-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12385">
        <property type="entry name" value="CHOLINE TRANSPORTER-LIKE (SLC FAMILY 44)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12385:SF96">
        <property type="entry name" value="CHOLINE TRANSPORTER-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04515">
        <property type="entry name" value="Choline_transpo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="95"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="227"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="252"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="331"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="381"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="431"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="479"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="514"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="579"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="612"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU368066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAG5096033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="676" mass="76405" checksum="1BA2858C7882DE77" modified="2022-05-25" version="1" fragment="single">ITDNSSEGDCKSKSIDRVTEYQTTNGDCHQEIKVTNSSCFGIWPFLKTFSQVKMGCCGCGEDDSAKIEPGSQERELSFSGSEVFAKKRSCTDLPALLILILIIAGYGFFVSCAVKKGDPFRLLYGYDDCANVCGRVTSKETNPEFSCKGADMRELRYHYAEFGVEGVKSRKCIENCDRLGNETIRFLNRCIVKTNGNNPTNALINNLGVKNFFNEAANDLNIAWRELIYLLLIALASSLGILIAFRYIVQYVIFIVLSGAVVISIAGTIYLWYNITLFNILTGVVLISADNDKQQSIHVYTHNYSRLLWYLEKKDVMAGKIDDEEAHIQAYLVYAILMSIVAVVTLLVVLVMRRRIALVSQLFKETGKAIYSMPGLLLQPIYTYIVISASLVTWLYIMMWIESAGDLYKNKKGHYHYKKNGLLEGARWYNIFMYFIMMQFYLGCQHMIVAGAVARWFFTRDKKQLSMPVTRSTCSLIRYHLGTVAFGALIIAIVKFLRAIFAYTAKYIQKYDNAWIKALLCCCNCCLWCFENTLKFLTRNAYIETAIYGCNLCGGGRKAFRALTDNILRVAAINSVGDFVLFLGKVLVVALTIVAGVYLIQKKDGLHHPWVPIVLGGLFALLISHCFISIYEMIIDTIFICFCEDCSRNDGISRPYYMSRGLMEFVENSKEAMKKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HDU5</accession>
    <name>A0A8J2HDU5_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS6113</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5092397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HDU5"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5092397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="242" mass="27369" checksum="C726E5BB62258684" modified="2022-05-25" version="1">MLIQTAASESRRNDGNLFSVNGPGQHIYKYNDEDGHFLTSSTEKINEDGSKSLIYEREIMEKAKNNTYIMRVTEEKIIDQQNSNVIKTIYTRVVQNIDDNNPNKSTYETYRSVSNPNSQKNSLFGDDLPASNMFKPRELGPHIPVGDLNVNLTQNEFDFTQHNKVPTPSTSDGNGTPSEQANKVVYLMPAPPTSSTRFARAANVGGRHQFFSTQFLTYFRPHSKKNSIHYMGRNLRALNCVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HEA5</accession>
    <name>A0A8J2HEA5_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Similar to Wrnip1: ATPase WRNIP1 (Mus musculus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HICCMSTLAB_LOCUS8026</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AAA ATPase family. RarA/MGS1/WRNIP1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5096071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HEA5"/>
    <dbReference type="OrthoDB" id="10265467at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008047">
        <property type="term" value="F:enzyme activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017116">
        <property type="term" value="F:single-stranded DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000731">
        <property type="term" value="P:DNA synthesis involved in DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18139">
        <property type="entry name" value="HLD_clamp_RarA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.272.10:FF:000001">
        <property type="entry name" value="Putative AAA family ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000137">
        <property type="entry name" value="Replication-associated recombination protein A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.272.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032423">
        <property type="entry name" value="AAA_assoc_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051314">
        <property type="entry name" value="AAA_ATPase_RarA/MGS1/WRNIP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008921">
        <property type="entry name" value="DNA_pol3_clamp-load_cplx_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021886">
        <property type="entry name" value="MgsA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13779:SF7">
        <property type="entry name" value="ATPASE WRNIP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13779">
        <property type="entry name" value="WERNER HELICASE-INTERACTING PROTEIN 1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16193">
        <property type="entry name" value="AAA_assoc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12002">
        <property type="entry name" value="MgsA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48019">
        <property type="entry name" value="post-AAA+ oligomerization domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0235">DNA replication</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="5">
        <location>
            <begin position="151"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAG5096071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="522" mass="57743" checksum="15BAB78F345534C0" modified="2022-05-25" version="1">MDNEVECPICAKKFSQSLIENHASKCLFLNESTSEPQTFFKRPRVDNQSKAKSPNVVKKVKKNVNTNLSQSQLFLSSSSSTDKRSFVDNIIDESPEEKSNKEIPVTTKPIKKQSHVPLAEQMRPTSFTDYVGQAHVLGGQSMLLQLLNKGEIPNVILWGPPGCGKTSLANVIANMCKKDPSGKTRYVKLSAAMCGVAEVKEATTIAGNDLKFGRRTVIFMDEIHRFNKLQQDIFLPHVEAGTIKLIGATTENPSFSLNSALLSRCRVIVLEKLTVANLLNILNRAVESVEGVIFKDSIDINSLSEVPRFLIDEKTIEFLAETCDGDARIALGGLELAIQSIVPNEKDLLTNGPELITLEDIKESLKKTHMLYDKKGDQHYDMISALHKSVRASDENAALYWLTRMLAGGEDPVYIARRLVRMSSEDIGLKDPKALGIAVHTMHACKMMGMPECDVLLAQCAIYLAKAPKSRLMEDALRAAQRIVREHKGPQPSHHEDSGLSYLPEGLEGVDFFNGEDPLEAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HF70</accession>
    <name>A0A8J2HF70_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Similar to Lac: Lachesin (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HICCMSTLAB_LOCUS6946</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5093610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HF70"/>
    <dbReference type="OrthoDB" id="10012075at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000376">
        <property type="entry name" value="CLUMA_CG000981, isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051170">
        <property type="entry name" value="Neural/epithelial_adhesion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12231">
        <property type="entry name" value="CTX-RELATED TYPE I TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12231:SF247">
        <property type="entry name" value="DPR-INTERACTING PROTEIN DELTA, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Ig-like" evidence="5">
        <location>
            <begin position="9"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAG5093610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="143" mass="16012" checksum="CDF7552ABCA66401" modified="2022-05-25" version="1">MFVFTAVSPTIFVPNQLMGAPAGKNVTLECNIEAHPRAISYWNFNNSMVLSNEKYTSSIMESSYRTNMQLTIRNLQLSDFGNYRCISKNSLGETEGSIRLYEMVQPSAPPTATEIKSSANKEGECSKELINKLMTNNLEQKKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HGH3</accession>
    <name>A0A8J2HGH3_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS9534</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5100399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HGH3"/>
    <dbReference type="OrthoDB" id="539213at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5100399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="118" mass="13281" checksum="21E27E1AB93C2C0C" modified="2022-05-25" version="1">MEWPQATGHSLGSLDYDTGNHHDQSHTSKDLCSGMTSIFDEKIKLSNIFITPLDQPENTSLKMSGANKVFKRSSTLILEDSDEYQMSMSCNNLLNSSDDPDPNTSTPEREKQSDRYVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HGJ8</accession>
    <name>A0A8J2HGJ8_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 15">NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial</fullName>
            <ecNumber evidence="15">7.1.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">HICCMSTLAB_LOCUS8276</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="15">Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>a ubiquinone + NADH + 5 H(+)(in) = a ubiquinol + NAD(+) + 4 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29091"/>
            <dbReference type="Rhea" id="RHEA-COMP:9565"/>
            <dbReference type="Rhea" id="RHEA-COMP:9566"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16389"/>
            <dbReference type="ChEBI" id="CHEBI:17976"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="7.1.1.2"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:29092"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 15">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 15">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="13">Core subunit of respiratory chain NADH dehydrogenase (Complex I) which is composed of 45 different subunits. This is a component of the flavoprotein-sulfur (FP) fragment of the enzyme. Interacts with RAB5IF.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="15">Mitochondrion inner membrane</location>
            <topology evidence="15">Peripheral membrane protein</topology>
            <orientation evidence="15">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the complex I 51 kDa subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.2" evidence="15"/>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5096571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HGJ8"/>
    <dbReference type="OrthoDB" id="42889at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006120">
        <property type="term" value="P:mitochondrial electron transport, NADH to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1440.230:FF:000001">
        <property type="entry name" value="Mitochondrial NADH dehydrogenase flavoprotein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.600:FF:000001">
        <property type="entry name" value="NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11540:FF:000001">
        <property type="entry name" value="NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.600">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11540">
        <property type="entry name" value="NADH-ubiquinone oxidoreductase 51kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.230">
        <property type="entry name" value="NADH-ubiquinone oxidoreductase 51kDa subunit, iron-sulphur binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050837">
        <property type="entry name" value="ComplexI_51kDa_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001949">
        <property type="entry name" value="NADH-UbQ_OxRdtase_51kDa_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011537">
        <property type="entry name" value="NADH-UbQ_OxRdtase_suF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011538">
        <property type="entry name" value="Nuo51_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037225">
        <property type="entry name" value="Nuo51_FMN-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019575">
        <property type="entry name" value="Nuop51_4Fe4S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037207">
        <property type="entry name" value="Nuop51_4Fe4S-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054765">
        <property type="entry name" value="SLBB_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01959">
        <property type="entry name" value="nuoF_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF010120">
        <property type="entry name" value="PRK13596.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11780:SF10">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] FLAVOPROTEIN 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11780">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE FLAVOPROTEIN 1 NDUFV1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01512">
        <property type="entry name" value="Complex1_51K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10589">
        <property type="entry name" value="NADH_4Fe-4S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22461">
        <property type="entry name" value="SLBB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00928">
        <property type="entry name" value="NADH_4Fe-4S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142019">
        <property type="entry name" value="Nqo1 FMN-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142984">
        <property type="entry name" value="Nqo1 middle domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140490">
        <property type="entry name" value="Nqo1C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00644">
        <property type="entry name" value="COMPLEX1_51K_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00645">
        <property type="entry name" value="COMPLEX1_51K_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 15" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="15" id="KW-0249">Electron transport</keyword>
    <keyword evidence="6 15" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7 15" id="KW-0288">FMN</keyword>
    <keyword evidence="10 15" id="KW-0408">Iron</keyword>
    <keyword evidence="11 15" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="15" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12 15" id="KW-0520">NAD</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="15" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="9" id="KW-1278">Translocase</keyword>
    <keyword evidence="15" id="KW-0813">Transport</keyword>
    <feature type="domain" description="NADH-ubiquinone oxidoreductase 51kDa subunit iron-sulphur binding" evidence="16">
        <location>
            <begin position="374"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00046881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU364066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CAG5096571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="469" mass="51588" checksum="43F80F57F459134E" modified="2022-05-25" version="1">MAGVIVRCTQISKRQLSFLGVVLNNQQVKTFSDAAPEGKKFGSPLNDQDRIFTNLYGRHDWRLKGSLKRGDWFKTKEILSKGADWIINEIKVSGLRGRGGAGFPSGMKWSFMNKPSDGRPKYLVINGDEGEPGTCKDREILRHDPHKLVEGCLIAGRAMGACAAYIYIRGEFYNEASNMQVAIAEAYQAGLIGKNACGSGYDFDIFVQRGAGAYICGEETALIESIEGKQGKPRLKPPFPADVGLFGCPTTVTNVETVAVAPTICRRGGSWFASFGRPRNHGTKLFNISGHVNNPCTVEEEMSIPLKELIERHAGGVIGGWDNLLGVIPGGSSTPIIPKSVCDTVLLDFDDLVRVQSSFGTAAVIVMNKQTDVIKAIARLISFYKHESCGQCTPCREGIGWMYKIMNRFVLGNAEKHEIDMLWELTKQIELHTICALADGAAWPVQGLIRHFRPVIEERMQNFKQSVAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HGP0</accession>
    <name>A0A8J2HGP0_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Mitochondrial ribonuclease P catalytic subunit</fullName>
            <ecNumber evidence="5">3.1.26.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Mitochondrial ribonuclease P protein 3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">HICCMSTLAB_LOCUS7854</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endonucleolytic cleavage of RNA, removing 5'-extranucleotides from tRNA precursor.</text>
            <dbReference type="EC" id="3.1.26.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the PPR family. P subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.5" evidence="5"/>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5095730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HGP0"/>
    <dbReference type="OrthoDB" id="46913at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030678">
        <property type="term" value="C:mitochondrial ribonuclease P complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004526">
        <property type="term" value="F:ribonuclease P activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097745">
        <property type="term" value="P:mitochondrial tRNA 5'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001682">
        <property type="term" value="P:tRNA 5'-leader removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18718">
        <property type="entry name" value="PIN_PRORP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11980">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033495">
        <property type="entry name" value="MRPP3_PIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031595">
        <property type="entry name" value="PRORP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13547">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13547:SF1">
        <property type="entry name" value="MITOCHONDRIAL RIBONUCLEASE P CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16953">
        <property type="entry name" value="PRORP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0540">Nuclease</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="6" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="PRORP" evidence="16">
        <location>
            <begin position="280"/>
            <end position="524"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00044536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00044559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF16953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CAG5095730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="529" mass="61980" checksum="2B220B6D3BA4F2D5" modified="2022-05-25" version="1">MSLTKLRWISLRRLLLTPDKLLIKRGVSIHYLEKDENLILNKVLVENEEFNNDKWLLIREDLCKSDFSINDVNVDCVIIDRCWVANKQDLAVSYVQYLLRTEKKKLNIGTIGRYFKALYDLHRPLDPQEIEEIYQLYDELMKEYPVVDPQTAENLISGLSLTERWKECLQLLDMVENSGSSRGTSYSSIISAAFDHNDFTIGWKYLESMYPRLHPNYYAYNSFLNYCTRASKNTPELEYVVNKIFQLWKNYDIIPPLDIVMLYVNTLTGTGEWTAEKIRIEKNGFCGGCKQTLEPLSLNEKEFKYLSHAVLSNTLVGDDVYNKTTPGELRRFKEFVNSTKPYDVCIDGLNVAYTLNRTKKSSNLGKELAAVVAEFLKENKKVFVLGRKHMTKWSPRDMEFVRKYCYIFFAHDLSQDDPFLLYATLASGMKTHFVSRDLMRQHKFLIQEEKAQQAFRHWQQCRQIFPMYVGTNFHRTLLLIRPPKYLPIAQKDSNGWHLPYYDESSSVSRAHDINIPEAPKTWICLRKKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HH62</accession>
    <name>A0A8J2HH62_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GDP-fucose protein O-fucosyltransferase 1</fullName>
            <ecNumber evidence="4">2.4.1.221</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Peptide-O-fucosyltransferase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">HICCMSTLAB_LOCUS8687</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>L-seryl-[protein] + GDP-beta-L-fucose = 3-O-(alpha-L-fucosyl)-L-seryl-[protein] + GDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:63644"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:17914"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:57273"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:189632"/>
            <dbReference type="EC" id="2.4.1.221"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:63645"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>L-threonyl-[protein] + GDP-beta-L-fucose = 3-O-(alpha-L-fucosyl)-L-threonyl-[protein] + GDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:70491"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:17915"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:57273"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:189631"/>
            <dbReference type="EC" id="2.4.1.221"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:70492"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyltransferase 65 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.221" evidence="4"/>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5097397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HH62"/>
    <dbReference type="OrthoDB" id="10050276at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046922">
        <property type="term" value="F:peptide-O-fucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006004">
        <property type="term" value="P:fucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007219">
        <property type="term" value="P:Notch signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11302">
        <property type="entry name" value="O-FucT-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11340">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019378">
        <property type="entry name" value="GDP-Fuc_O-FucTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039922">
        <property type="entry name" value="POFUT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21420">
        <property type="entry name" value="GDP-FUCOSE PROTEIN O-FUCOSYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21420:SF10">
        <property type="entry name" value="GDP-FUCOSE PROTEIN O-FUCOSYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10250">
        <property type="entry name" value="O-FucT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="8"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="17" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="13" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="12" id="KW-0294">Fucose metabolism</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9" id="KW-0914">Notch signaling pathway</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="repeat" description="ANK" evidence="17">
        <location>
            <begin position="407"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="17">
        <location>
            <begin position="456"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="17">
        <location>
            <begin position="489"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="17">
        <location>
            <begin position="521"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="17">
        <location>
            <begin position="565"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="17">
        <location>
            <begin position="609"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="17">
        <location>
            <begin position="642"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="17">
        <location>
            <begin position="675"/>
            <end position="708"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00021745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00033080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="CAG5097397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="869" mass="97711" checksum="6EEDB058F60A6455" modified="2022-05-25" version="1">MLVVSNFKEITALAQIHLHQHSMTSLHGRTAKLATWIPVAARARRRQREPASYGLIDVDTNGYIAYCPCMGRFGNQADHFLGALGFAKAINRTLILPPWVEYRTGEIGSVTFCYSSRGNSESCNAKEGNPFGPFWDNFNVDFVDSEFYGPFHYDVHHTDIASQWRKKYPAVSWPVLAFTGAPASFPVQLENKSLQKCVVWNDEMLNKAKKFVKGSLPPGAFVGIHLRNGIDWVRACEFISSSPNLFAAAQCLGYRNERGKATDSMCLPSLEVILKHLKRVIRNGKNIKSVFVASDSNYMIEDLTNNLSRMNISVHRQPEPASPHLDLAILGRSNYFIGNCISSFTAFVAREREKMTSYVINSSYSHVTLLHKAVGNNNYKEATNLINLGENVNSICHYPAKKYKNNTNCTALHLAVSKGNKKIVELLLKNNADINIEANCLDSNEDPKYSVAKEYFNRTPLLLAVAQENKEIVELLIKNNADINLKTSTGESALGLALKSNNKELIEILLTAGVDINLHSENVTSLHWAVANNNYLVAEYLINHGSDVNTVCHYPPREFFNTCCSPLHVAVKNQNKEMVELLLRNNADVNVKANCDKTTPCYVPVRDYFNRTPLHIAVDKEDKTIVKILIKHKADVNLTTKTGETALSIAVKKENLGLIKLLIHADAHVNSINPSHVSPLYLAIIRQENLRVLEFLLDHGADFDNIVDFGGNLIALHNYDRSIKDVIKRHIIKLEALGLFSGPYFGTIGIEFDIFTKNCNEEIEKLKKVGININKITFFDVLTMCQHKLAMKLTHVNKDNLAHLKTKAKLTFPLYGELVKHHLTKAARRKKLLIKANITLTNIFKSALPNIFLREMYYYFSNQDLNLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HIA7</accession>
    <name>A0A8J2HIA7_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS9692</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5100619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HIA7"/>
    <dbReference type="OrthoDB" id="6369833at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5100619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="121" mass="14348" checksum="3BDE64D9F59E66A7" modified="2022-05-25" version="1">MVKKYWNTLWLQSPTKLHDVRKDIYEDVPTFGRREQCVLHRIRIGHTNITHSFLISKKSRNLCQSCNTPSTVRHLLIECNNFQQARQRAGFTNDLQVMLKDDEKCRKVLAFLLEISMFQLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HIY2</accession>
    <name>A0A8J2HIY2_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Tektin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HICCMSTLAB_LOCUS8718</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Cytoskeleton</location>
            <location evidence="3">Cilium axoneme</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the tektin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5097459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HIY2"/>
    <dbReference type="OrthoDB" id="9886517at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005930">
        <property type="term" value="C:axoneme"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015630">
        <property type="term" value="C:microtubule cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060294">
        <property type="term" value="P:cilium movement involved in cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048256">
        <property type="entry name" value="Tektin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000435">
        <property type="entry name" value="Tektins"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19960">
        <property type="entry name" value="TEKTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19960:SF11">
        <property type="entry name" value="TEKTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03148">
        <property type="entry name" value="Tektin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00511">
        <property type="entry name" value="TEKTIN"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0966">Cell projection</keyword>
    <keyword evidence="3" id="KW-0969">Cilium</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0282">Flagellum</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="78"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="310"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="369"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU367040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAG5097459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="440" mass="51524" checksum="C74F387F5F22EF22" modified="2022-05-25" version="1" fragment="single">LIQPWATVGSSMACLEPVIPVRGKPLKFPNLVTGFQRNPVHASQSALHTRYTPNEWFQKQIKYYNEADANTYYSERIRNDAVKIMRAAEEKIQNFQHDSDRRLGERITDVTFWRNEVASELERLIQECERLQDCRAVLEKAVQDIEGPLHIAEECLYHRTELVHDDSEKCLLSELSNLRSSQKKLEACLDRVKDQLRNCRASQNQLQLDMKNKESALGIDTLCHQLNNYSHGIQYYSGIEKYDPCVSEQETWADAANRIVQKSQTERAKSVQLRAEAESLVNRVSREMWESWTYSNNALARRSSEMLEAKSQLQQHLHKVQQEIFDVEKNMEVLRKAIADKSYALKVAHTRLEARMHRPELELCRDYAHVSLQKEIENVNREVDKMHRMLKEIECQHQRLLRTRNSLEHDLALKIDAMYIDKEKVCGLRRAYPVNALFRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HJ04</accession>
    <name>A0A8J2HJ04_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Similar to swm: Zinc finger protein swm (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HICCMSTLAB_LOCUS11293</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5103005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HJ04"/>
    <dbReference type="OrthoDB" id="443401at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12257">
        <property type="entry name" value="RRM1_RBM26_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000330">
        <property type="entry name" value="RNA-binding motif protein 26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002483">
        <property type="entry name" value="PWI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045137">
        <property type="entry name" value="RBM26/27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14398">
        <property type="entry name" value="RNA RECOGNITION RRM/RNP DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14398:SF0">
        <property type="entry name" value="ZINC FINGER PROTEIN SWM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01480">
        <property type="entry name" value="PWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00642">
        <property type="entry name" value="zf-CCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 6" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="9">
        <location>
            <begin position="321"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="6">
        <location>
            <begin position="321"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="84"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="124"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="385"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="604"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="788"/>
            <end position="893"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="124"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="137"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="154"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="184"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="205"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="224"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="253"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="394"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="613"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="624"/>
            <end position="672"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAG5103005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="929" mass="106578" checksum="82796960EA933677" modified="2022-05-25" version="1">MIIENPEQFKNWLTTVLEPLCDADPAALAKYVYALVKKDKTLEELQEGMVEQLDVFLQHETKKFVDLLFKTLETQDYLLQAPQGNLTEPISSPRINPSEHSVNSEQLVEPTVTQLCSITNPALSVQTNGSTATSTLNKRESRKSESEKEDKDKRTRSRGRFRSRSKSRSRSWEKDRRRSRSREHRRDRERDRSRLWRNKSPPSTVRRHERRRSRSRSSSSLRIRVREIADSRDHRIRFRNRSPTPLRSRSRSKSTEKKNIDKTEKLVDESRLDCIETSPAGTPSQDNNHGDIDMRLSTASQSIQSVVALTSNISKNQIGEFLLKRRCRDFDEKGYCMRGDLCPYDHGTDPVVLEDVALSRVLTFGPHGSQTVGTETVPTISNSSLGQNGTVQPPHVPLANLPPPNLRNPPHSNMEYNPDAPSMEPRISWSRHSQSNMGIYGRGERELIRVPVIPHIQPPETVHSQTTSSLKRKQTFDFNRLGPKQRLNHNSANCSLELKKVPRTLNNITQLNNHFSKFGKIVNIQVNFGGDPEAALVTFQLPSEAKAAYRSTEAVLNNRFIKVFWHSNINNTAASSAIENVPPGCRPSVKERLGAAVPLSIKLDDNEYVPTRRSNDDQQENERAPQQQQQEQQPQQKQQQQQEKQVSQQKLDQEHQQQQQNKKQLLPDQQQQLQQSQEQQQQQILLLLQQEKEQEPKKQEQQLLLLLQQHQEQQPQEQQQQHQQKQSTTNFIIPSQKNKTIASTREEKVYAIKKTQEILAVKETLKKKQEQKRKEVIKITADLRKRKQELLDKNLMEIRTLIEKAEKNPEQKDAIMETIKVIQQSIDQLRKDLAANGQSSGTKLLVKSREQTQKEILDAELDLMTAHQEGQDAGELQKRLNELRAQAAVLSINATKGTNKNVKSSRVVRGGHNFTCRGRGNYMHVSACR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HJA3</accession>
    <name>A0A8J2HJA3_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Similar to Kibra: Protein kibra (Drosophila mojavensis)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HICCMSTLAB_LOCUS11369</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5103157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HJA3"/>
    <dbReference type="OrthoDB" id="2020426at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019900">
        <property type="term" value="F:kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060090">
        <property type="term" value="F:molecular adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046621">
        <property type="term" value="P:negative regulation of organ growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035330">
        <property type="term" value="P:regulation of hippo signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051105">
        <property type="entry name" value="WWC/KIBRA_Hippo_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14791">
        <property type="entry name" value="BOMB/KIRA PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14791:SF29">
        <property type="entry name" value="PROTEIN KIBRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00397">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01159">
        <property type="entry name" value="WW_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WW" evidence="5">
        <location>
            <begin position="9"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="domain" description="WW" evidence="5">
        <location>
            <begin position="343"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="109"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAG5103157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="425" mass="49158" checksum="7D3B98C0619B2E38" modified="2022-05-25" version="1">MPRRRNGEIPLPEGWDVAQDFDGKVYFIDHNTRKTTWIDPRDSRYKQDGVRFVPFIKPQIDKKKCLEWIHLSRKADLTVEKIKKHTYICTKHFINSNGPTAENPNPLPATVSKIPKDRKRQQRCVDENSSTGKNKRQKLTCFTATDDELITGQTDNKNANSHQEIQLNIDLSSEPENYNNFLTPNNAERVVEPPMQTVSTCDANSQTEEDTEVKQLKKCIECLEKKLESEAFDVDSCRNNVKKFKYYTGLKPEDFDTLWEFLGPPAAESLRKWLTTEPKTNRESSRTQTKVSLKNQLFLTLIRLHSGLLLANMSYRFNVSIGYLSKIFTTFTKPQTFADCIGNELPLGWEEACDKHVGAYYINHVNQTTQLEDPRQEWRAIQEAMLREYLQTAQDVLEVKPPRPDLSLKVIKAVMIQISYNFINT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HJD5</accession>
    <name>A0A8J2HJD5_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Similar to dlc: Delta-like protein C (Danio rerio)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">HICCMSTLAB_LOCUS8994</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5098021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HJD5"/>
    <dbReference type="OrthoDB" id="6130531at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005102">
        <property type="term" value="F:signaling receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007154">
        <property type="term" value="P:cell communication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000018">
        <property type="entry name" value="Delta-like 1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.140:FF:000002">
        <property type="entry name" value="Delta-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000118">
        <property type="entry name" value="protein delta homolog 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050969">
        <property type="entry name" value="Dev_Signal_Modulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001774">
        <property type="entry name" value="DSL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14949">
        <property type="entry name" value="EGF-LIKE-DOMAIN, MULTIPLE 7, 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14949:SF54">
        <property type="entry name" value="VWFD DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01414">
        <property type="entry name" value="DSL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00008">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21700">
        <property type="entry name" value="EGF_DL_JAG"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="9 11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 11" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="21"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="290"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="336"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="14">
        <location>
            <begin position="427"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="14">
        <location>
            <begin position="621"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="185"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="208"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="450"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="652"/>
            <end position="661"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CAG5098021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="768" mass="85139" checksum="BC1FAB4E5E55BCD0" modified="2022-05-25" version="1">MARNDHYFKHESPPAIGTLRNLKSFIIFYLLLCYFFLPAPSRGPVRASANEVAIFLRQVAPPSVNGGWKESGFFSGNRVPSLRQDTWLIVVSEETIRHYSWQEWTPTLESLKEGPFVEASLSWFDVNEQLRKQRDVEQKRFNDRVRQFYLEKYGEKVLVEWRSSQDTPIPEKVFRRFFFRRRSDENTQPPSLEHQVRQSPLESYNRDGDDDDDDDDNQETYVVSWMPETGGLMGNQVVDTKFAQISLLPGTKYLVRIASNDGPGSFPIEIDTRSSSVDVWKVKKKNDDDLLPWAFLAAIVAALAIIVVIAGVKIFRLSRTPKVVPDEEISSARSRVKMILVLLCLLPLFGGSNLVVAPGYSSPGIFLVATAGLGALPSGFAAGPRYVPKWKKQACEIPAAQHPGSHYVCDEAGEVKCLPGWTGDLCDVPLCRKGCDPLQGYCRRPGECRCKLGFYGELCDKCVALPGCQHGRCNVSFECACDPGWKGLFCSEPICDADCHPSQGYCEKPGECRCRLGWQGHKCKQCSVLPGCVHGTCQGPLECRCKPGWTGIVCQTPICAPGCSRENGGCRRPGTCRCRVGWTGQNCTECVPYPGCVNGGCRRPWECRCQPGWTGDLCDEKLTFCDDHPDVCQNNATCVSMTKEDGDFRCICPIGFTGRKCQIQTVEPAADLMPPIPETATIPMNSTEIPPELSTTASKNRTTVSMVNSHQGHWDDEVTEKVQGTTIEPLGPIMVTDPSTVEPAATAGKWPIELDDDPIIDSDIDNEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HK39</accession>
    <name>A0A8J2HK39_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS8992</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5098017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HK39"/>
    <dbReference type="OrthoDB" id="7689200at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035228671" evidence="1">
        <location>
            <begin position="19"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5098017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="114" mass="12676" checksum="62E8B6FAAFE5318A" modified="2022-05-25" version="1">MAKVTIIILMAVLSLALGAAIKKKEIDFKKDKRGLIDLGYGYALTPDYIYSQKEYVLQPQVSVYNPYHLGGVKSVPVAPTFHQIPLAVQVPDATFHQPYAQHYSYGIAQPIIID</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HK88</accession>
    <name>A0A8J2HK88_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Serrate RNA effector molecule homolog</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Arsenite-resistance protein 2 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HICCMSTLAB_LOCUS10659</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ARS2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5101758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HK88"/>
    <dbReference type="OrthoDB" id="342064at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016604">
        <property type="term" value="C:nuclear body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031053">
        <property type="term" value="P:primary miRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039727">
        <property type="entry name" value="SE/Ars2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007042">
        <property type="entry name" value="SERRATE/Ars2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021933">
        <property type="entry name" value="SERRATE/Ars2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13165">
        <property type="entry name" value="ARSENITE-RESISTANCE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13165:SF0">
        <property type="entry name" value="SERRATE RNA EFFECTOR MOLECULE HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04959">
        <property type="entry name" value="ARS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12066">
        <property type="entry name" value="SERRATE_Ars2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0943">RNA-mediated gene silencing</keyword>
    <feature type="domain" description="SERRATE/Ars2 N-terminal" evidence="9">
        <location>
            <begin position="182"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="SERRATE/Ars2 C-terminal" evidence="8">
        <location>
            <begin position="906"/>
            <end position="1087"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="295"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="828"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1095"/>
            <end position="1134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="8"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="45"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="97"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="300"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="313"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="368"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="400"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="411"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="423"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="504"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="527"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="546"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="578"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="596"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1097"/>
            <end position="1113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1120"/>
            <end position="1134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00030701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF12066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAG5101758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="1134" mass="126731" checksum="684D8C17C66AFC75" modified="2022-05-25" version="1">MGDSDDEYDRKRRDKFRGERPESYSRGGDGRRDDRRGGGGGGGGGRDEWPEREWSSRSRTRPDYRDYRGGGGGGGNRDRYSPVRSQEISSGPPLKRMRGEWDDRPSSRYAHSDYYMGGGGGGDRGSSWAPPSDHYMSHHSNHHYGSGGGDRHSNNNSNNRSEVAGNFSNSNIETQPPMMTFKAFLVTQEDSITDEEAIKRYNEYKQEFRRQQLNEFFVAHKDEEWFKIKYHPEESIKRKEEQISALKKRVEVFLELLNAGEIDKVSIDVDQSTPLLRLLDTVVIKLEGGTEEDLKVLEDAPAAPTTPLAPKEVISKEPQKDKEKDKDKEKDKDKDKEKDEDVPEKKDEEEISDKPAEEPMETVTVKDDENDNDEEVNKQEDEDNDDDDEDEDKPTESSAQEEKPVAALKEKGKKSKKSKKSKKEAADQDKEKSDEQDDSAKAEKIIDGEEEPVDNNNQDENMEIPLATAEVAASNSKKRKRTASNSSSSSVEDNDANDNRSTTSNKSSASSNSSSSSSSSQSSPDNNNEENEENEENENENENEVENEKMDTADNANEDEKPEAVEEKSQLSPSGSTDKNKIDDKSGEGGEEESKDTDKDKRDDKASKNQVEAVIDLVETGEEDKDEKDSATVNPPRALHKTSSIFLRNLAPTITKAEVEAMCKRFPGFLRVAIADPQPERRWFRRGWVSFERQVNIKEICWSLNNIRLRECELGAIVNRDLLRRIRTVNGITAHKQIVRFDIKLTAKIIHNLDAKIGLWVDPSNVSSNNKDGEEVADNNKDASKKTDNIVMEVMPLEFGFSSKNPVLKNITDYLIEEASAEEEELLGRGNVDGGTGSGEQQEEGQLEGANENSDEGPIDRDPALTKVLDRLILYLRIVHSVDYYNHCEYPNEDEMPNRCGIMHVRGPPPQNSKVSFTELQEYCRNFESKMSNFLAPSSSSAPGMPDEEFQKLGAKNAEAEVEKFVQANTQELAKDKWLCPLSGKKFKGPDFIRKHIFNKHAEKVTEVKAEAEYFNNYLKDPKRPILPEHPGNKAPAAAANAQGPREGLLRDNYPPFGGMGGFGGYGGSNFGSGRGIFGSSGGYGGGFGGGFGGGMSRPSRGGFNRGRNSNNPDFRPVIHYRDLDAPREPDEFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HKI2</accession>
    <name>A0A8J2HKI2_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Similar to sas: Putative epidermal cell surface receptor (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HICCMSTLAB_LOCUS12043</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5105992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6022609at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005178">
        <property type="term" value="F:integrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045597">
        <property type="term" value="P:positive regulation of cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050941">
        <property type="entry name" value="CCN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001007">
        <property type="entry name" value="VWF_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11348">
        <property type="entry name" value="CONNECTIVE TISSUE GROWTH FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11348:SF34">
        <property type="entry name" value="EPIDERMAL CELL SURFACE RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00214">
        <property type="entry name" value="VWC"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50184">
        <property type="entry name" value="VWFC_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035155990" evidence="4">
        <location>
            <begin position="25"/>
            <end position="1450"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="1387"/>
            <end position="1412"/>
        </location>
    </feature>
    <feature type="domain" description="VWFC" evidence="5">
        <location>
            <begin position="559"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="domain" description="VWFC" evidence="5">
        <location>
            <begin position="638"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="6">
        <location>
            <begin position="1227"/>
            <end position="1323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="374"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="899"/>
            <end position="919"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="902"/>
            <end position="917"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAG5105992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="1450" mass="162697" checksum="44B8DB84422F255C" modified="2022-05-25" version="1" fragment="single">MNIQRKCILLFIFIISTTITTVLCKFNKQKNEFIQDEKIGNLHRRRIRTINDETSNHSNNGQDKIPGVISLDEMTPLQQNNFTGNNLSEITSTTNLTEKLLKLKQIHYNQKINYTINNSSSIIYDEDYKKNETDDKNNAKDIINNLNGTSTISMPIVETLVTNFSRARALDIPSSSLEPTNSLSANLTDLSDVSMDENDKQIEGGEYILHHNETNFKISPIIFSREQKCIEPNNKTYQVGEIIIRGCTEKCICGKNGTVDDCQPIYCENPLVKAIGKSQDPFCHKQKIHDNECCAILVCSSINNNNNNNNNNNNSNYQSTGTCYFIGNDNVNKTIDIGQHIEDGCTRICTCETGGILNCKPRCPLLDANNYNDNDNDDDEKKNKSNLQNSDNNDRCVKLEDPRDSCCTITYCDVSIGEHELMASTDATLSATTIKSLKNKTDEILTNTYINNDQIKILNSTAIKILLPTELININKTIVEISNNNHIWKRKNFNKEGIISNLEPSSVYYIRIKTEDKNNKTISTISVVTLPPSSSLPQINILKNKITNNSTTIKIDSKDSCSYRGKLYQIGSEWYDECINFCVCEKGPKTQCVTIECPTDFGLDVLDPNCLDWETVPFNFVPKAPQCCPEEVRCRNNGSCNYEGVVYDNWNEIPNNITGCDKRCYCEMGNISCQPACPPVPALPPDTLSCSSNQAILTKLPDDECCLHWICGSQVNNNENYHTFMPETNSTVFVDDTVSSIGSPMSGNNVANGMKKNWQSFITTDESPLAPDRLPSSLASKDNFAITINPMVVINNSNNIDNKTQFDQNNGDKISSSNKFNKNKFINIDGFNKQVTVPSTGDNYSSLLESSTKSEIPSIPSINSDKIKFDKNKFSSSDKLNHLTNFNYPELSQNTKQHFDTSLSSSLLPQQQQQQQQEINKNDKFLKPEIKAQKNENDLPDTSSGHIYSSLGFPLHGDGVAASEYLNKVSGQLSSSSSNNEIIIKSLDAIDDSTIRILFTVPSVLVGLFGRVELRYTNEIMNSDLSTWKSQIFIPPNDLIATPQLEFELDGLEPSTEYKLKVTVILRNDQINNNNNPNSKIYSVKTLDRYTDNKDLKHTLINKGTTESIKTMTTEISSPHQIFIDAGLKVVETNFSWIKVEWKKFTEFEIKFIDGIQLRYKEYDSKVYTTTPLIHRAVTSWIIEGLKPATTYQIGISIIPFPGQTTELYSEKTIQITTSIEPDPYSFDVKVEIKMIKSQEIELSWSGVPYPEDKYVNIYRAIYQSDSGKGDTSTFKIAKRDSPAKTIISDLKPGTRYRLWLEIYLTNGKIKKSNVQDFITKPGIDLLHTASTGNIYQSGKYGITASAAAAVSIPSSHQENNHYNNNNHNSKIINSNLNNSNDNNNNYYGPLVIVAIVASLAILSTLILLMMLMKRRSSNKAEISSSRKTTASAAYDNPSYKVEIQQETMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HL31</accession>
    <name>A0A8J2HL31_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS9645</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5100572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HL31"/>
    <dbReference type="OrthoDB" id="8061146at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140996">
        <property type="entry name" value="Hermes dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5100572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="130" mass="15078" checksum="C47A123B9A4EECF1" modified="2022-05-25" version="1">MYYTCNNTAEQQLKSHRKTCIWEVENSNIDDSSDDSVVRHLSLKRKNRSGSYEENNNCTTTCNTDGVITLSTVKLKKNTPKINSFIDKISETEHSKLDEALSYFFFSKNLPFDLVEDEYFIKFCKTLRPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HM45</accession>
    <name>A0A8J2HM45_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Pre-mRNA-splicing factor 38</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HICCMSTLAB_LOCUS8639</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Required for pre-mRNA splicing.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the PRP38 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5097301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HM45"/>
    <dbReference type="OrthoDB" id="3881at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005037">
        <property type="entry name" value="PRP38"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23142">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR 38A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03371">
        <property type="entry name" value="PRP38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5 7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0747">Spliceosome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="235"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="275"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="295"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="354"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU367025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAG5097301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="364" mass="42820" checksum="7568E927031BB59F" modified="2022-05-25" version="1">MQNQEDGVEGSPWNNSSGCEEERKPREGKKSNVLALWGNERTMNLNPLILTNILSSHYFKVNLYELKTYHEVIDEIYYKVAHLEPWEKGSRKTAGQTGMCGGVSMFLSLRFMQVRGVGAGGIVSTAYCLLYKLFTLRLTRKQLNGLINHPDSPYIRALGFMYIRYTQPPADLFSWYDEYLDDEEEFDVKAGGGQMMKMGEILKQFLTKLEWFSTLFPRIPVPIQKELEQRLSERFPQQTINARNAKPPITLNNHGKYSSSRKDNGNSTARSQPRHISDSDAHWGEAESRTSQWRARSDEERRDSRDKHRDRDRERKRSRERDRSKDRDRGSSRVEETRKRDRHSRRTSRERSREKNRRHRSRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HMC4</accession>
    <name>A0A8J2HMC4_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Similar to Nup160: Nuclear pore complex protein Nup160 homolog (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HICCMSTLAB_LOCUS11856</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5104146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="67716at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059141">
        <property type="entry name" value="Beta-prop_Nup120_160"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021717">
        <property type="entry name" value="Nucleoporin_Nup160"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056547">
        <property type="entry name" value="NUP160_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056536">
        <property type="entry name" value="TPR_NUP160_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056535">
        <property type="entry name" value="TPR_NUP160_M"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21286">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP160"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21286:SF0">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP160"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11715">
        <property type="entry name" value="Beta-prop_Nup120_160"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23345">
        <property type="entry name" value="NUP160_helical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23354">
        <property type="entry name" value="TPR_NUP160_120_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23347">
        <property type="entry name" value="TPR_Nup160_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Nucleoporin Nup120/160 beta-propeller" evidence="4">
        <location>
            <begin position="60"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="domain" description="NUP160 helical" evidence="5">
        <location>
            <begin position="536"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="domain" description="NUP160 middle TPR" evidence="7">
        <location>
            <begin position="812"/>
            <end position="1075"/>
        </location>
    </feature>
    <feature type="domain" description="NUP160 C-terminal TPR" evidence="6">
        <location>
            <begin position="1122"/>
            <end position="1374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF11715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF23345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF23347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF23354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG5104146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="1388" mass="158120" checksum="B475F4B2A0A5D089" modified="2022-05-25" version="1">MIEFPLGYREVVPDQTQPENWKEIILNTGGSQSTLQDIKVPERASGYSYRDNYKYYTRNRFIYWRISHDILELIEHSFDINLINCKIRYKFTDTPILDGISIHETVNSVEHLLISHPDLTIQSIFSEASAQVARDPHSFHVISNIGTTNSPVPHAAASWLTLNPEEALFALAYNTGTILLLRLDGATGLVHTSELKQDSIMPRFLSGIATAFRGRNTEGMVAMSLVIHPCGDDTYLFALCREGNVRMWSCNKAQCVAVTEVSADSQVAQGAHGHMLRKILGSTDNELYLGTYLKFNYGCEFSILRPVQDAGLFKFIRVCTLFPPDQHLVDFAFTPTRLWAAWRTTDLDTVAVTHAQLPLSGAQVTSEWETAILEPIPDRDYIITDPGTDPSQAYLSYIFHPGQFSLADITRALNIYRRSNFMADMTLSPALLKERVCMAVEAEIQAEVMDYELTDEDYLEIANRCWSKFYSCVIQYHVNGSRPVGILLLPTVYGVVLLKKSFFSLLRPMEALEHLLLSNEKSYASRFKTTAIFSQDEETCQDLIELMEAVVMLEEQLSEETKSNFQRELSYLKSPDIVVEELFSRLLTDPDDPLADYDFQLDLYNKLENVRDPANAMEMLLEALTYDTVQPEKLKLDSEPETSRMLLTVSHLFGSQLGISTVSVSVSQITQLRFTICRNLLLLQQIILARPEVSISRILHEIKSSLAPRTVVLTQAYFVMNWICESTINLQSRQTLLETSIQRLQSLKLNEGRVTSRHQRSTSLLELFIQSSGAKHAYTLMANNMELDASTLVPWHFGMLTHVNLIGQLISPLCGNFVFPEWLLSSCQFNLVQDYVRLLSTWCEWNSASRKFILAVSLLELGETNKACDQFLRASNGILTDKFLASILLDATPGSDSNALVQYYLKIIELFEQHGPSKYIIELAETAITIAEKDNPNLPTLHSIIFTQHLHLGHHKEAYHCLNSNPDAARRSDCLRQLVVTLFERKKLIDLVSFPYVDMYEELERIVVGRARSVDLMENNYYNFLYSFHIEKNNIRKAASVMYEQAMRLSQESHSVQIITRQAQCLLACINALNLVRENYRWIVKPVVDQTYPDEVNPKKKRTFCGKEILHYKIKKMVQVLELKDIRNEYYLVDARLKLSKFRSEMHTIAQADAGELIVLLSNVGLYTVALNLCDKFGISKTSVLENLAGQSLRLSEHEDPNAWDWLVLNDVFDIPGYGSNVADIAWRLLEKLTLEHEKEDSSELHKGVAKKILQHEAFLPQWLIASYKKRNAAELLRLILNSGRLLEATDLAVDYINAVLGEGKEYFGLDSPLVMSGPAVWLPFNTFEVLLLELEHASKEDPTYIESHENLNNKLECYIDTVVRVSNDMVRFKVQSSNNSKYNYIYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HMD7</accession>
    <name>A0A8J2HMD7_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similar to Vps33b: Vacuolar protein sorting-associated protein 33B (Rattus norvegicus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS10944</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the STXBP/unc-18/SEC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5102296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HMD7"/>
    <dbReference type="OrthoDB" id="10262528at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.850">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1910">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.830.10">
        <property type="entry name" value="Syntaxin Binding Protein 1, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043154">
        <property type="entry name" value="Sec-1-like_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043127">
        <property type="entry name" value="Sec-1-like_dom3a"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001619">
        <property type="entry name" value="Sec1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027482">
        <property type="entry name" value="Sec1-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036045">
        <property type="entry name" value="Sec1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043155">
        <property type="entry name" value="VPS33_dom3b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11679">
        <property type="entry name" value="VESICLE PROTEIN SORTING-ASSOCIATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00995">
        <property type="entry name" value="Sec1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56815">
        <property type="entry name" value="Sec1/munc18-like (SM) proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5102296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="565" mass="63688" checksum="F31C3C0482E78CBC" modified="2022-05-25" version="1">MDITFDDKLNALQQISQRKLIDILDQISGKKDFIIEQTLMKPLDSFVGVTVLKKHGVDKIYLLEPGLKPTNSHRIFLISSNLISCKRVLDQIQSEMSQSDGLNFHILINPYIPTVVHSLIEEEGLADLVTVRALSWEFIRIDDNVLSLECPIFVDLYYHKDTSLLSSLARNLWSLQLILGWPKFSMSFGKHSDQVLKMIETIQEDTKSTNCSSNEIGGLIIMDRSYDLVSTFLTPVSYLGLLSEVVPITVNTAAIDKASIKLDPKKDQVYEDIRDIHFSDVFPKLRAMAKALKSEQEATQDMKLAEMGHYVATRLSKTAEVKRLLASHISACEAIISALGSEFETLQSMEKSILECTKRKECLDYIERNINDYPIRSLRLLCLLSITSSGLTPNESHIIQKSHLHAHGYEYIPLFYKLEACGFLRQKKENILNKLPTWSGEWTSNAQRMKLLPNQSKKSEDTSVCPSYVFSGAYIPAIAQFLKTVISQVSNPKGYEDLINLPECHVNRPRTVVQPKIVIICIIGGITYGEISACRFIEKSMGIKLAIVSDCLLTSDKLFKSIQDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HMF8</accession>
    <name>A0A8J2HMF8_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Similar to Bcl3: B-cell lymphoma 3 protein homolog (Mus musculus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HICCMSTLAB_LOCUS11637</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5103693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HMF8"/>
    <dbReference type="OrthoDB" id="10254947at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051059">
        <property type="term" value="F:NF-kappaB binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071356">
        <property type="term" value="P:cellular response to tumor necrosis factor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051070">
        <property type="entry name" value="NF-kappa-B_inhibitor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46680">
        <property type="entry name" value="NF-KAPPA-B INHIBITOR ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46680:SF2">
        <property type="entry name" value="NF-KAPPA-B INHIBITOR ZETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="640"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="41"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="387"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="14"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAG5103693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="732" mass="80337" checksum="2A240982F7301D41" modified="2022-05-25" version="1">MESESAIPRKRARSSSSSGQPAPNLSLTECVREFALPQAYPSMAKGNDSSSEAKAPAGATQKSMKLAKFKIKTKDGRELDMKIMPQNTPVTSLNGKTISFSLAKPLIRSDQPVNIITKGDTLVTTATGTSDIKPSMLASSQDIYKSLNKNPNSAVKYIIPPHLRGVKLLSDFNSRVNMPSRSNVTNSIYQLDDNNIVVSNDDSIDLTGSSYGEGESNGIVMQQGRGWRVLKKEPERTVLRNVQNKSANITDDNNLNGQKPALLRRGTSLLNRGKNLPFKTVKNANQSNIINKQVNSNGQPGSRLIRIAGNKRGFDHGYALAADISDQNMINIIDDSNGIINLDDSSNLDGNTVYVFQNDDLLDQEQAEAEVNVKNTPQSVPLVNSQGRVNLIRRGNNKSTNSSSNKLKKDGNPRKSGSPMESYRSPYLREDLTDEELSDKLNVVGEALSTVSDGDLKMRALRALEECGFGMERFIPKKPPHNYLSVKDTSSQTNVFGLLDKNDFIRVTGDSNGVERLHEIEKQLINGSKEVKRKPCTDTANFKEALDEMLDKDVWVDKTRVEQVKNMLKINPTSLELAIQHSAQPEIVSLLLKNGANPVSPENAHDSALIIASRMSSDHLPQLVKSVSPNNPAINNVDSEGFTALHHCARNGNYRGVMCLIAISADVNARDGKSGRTALFHAFENEGINICKELLTAGAKPNIPNFAGHTVLSIFDEEKHFLLKGYIQKYQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HNL2</accession>
    <name>A0A8J2HNL2_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS9731</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5100658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HNL2"/>
    <dbReference type="OrthoDB" id="7761718at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5100658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="82" mass="9521" checksum="57A910D2A5F89921" modified="2022-05-25" version="1">MKDVDKSIAKKSTLECRGIKGLSALSTLPNFDMVWSFPFDSMHTWDLGVTKFLWELIIKGLDKDEKERINQVIKMTKPPRCY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HNW2</accession>
    <name>A0A8J2HNW2_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Vesicle transport protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HICCMSTLAB_LOCUS12514</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="1 9">May be involved in fusion of retrograde transport vesicles derived from an endocytic compartment with the Golgi complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 9">Membrane</location>
            <topology evidence="2 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8 9">Belongs to the SFT2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5106946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HNW2"/>
    <dbReference type="OrthoDB" id="73614at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007305">
        <property type="entry name" value="Vesicle_transpt_Got1/SFT2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011691">
        <property type="entry name" value="Vesicle_transpt_SFT2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23137:SF6">
        <property type="entry name" value="VESICLE TRANSPORT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23137">
        <property type="entry name" value="VESICLE TRANSPORT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04178">
        <property type="entry name" value="Got1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="44"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="69"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAG5106946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="91" mass="10187" checksum="D2D58A4C6741FD9A" modified="2022-05-25" version="1">MDKLRRALSGHDQCDEESGIMTQHESDYLISDGTTLSWSTRIKGFAICFIIGILLTFLGSFALFLHKGLTVFAVFYTLGNIVSLLSLRRLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HNX7</accession>
    <name>A0A8J2HNX7_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Similar to Kcnk18: Potassium channel subfamily K member 18 (Mus musculus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HICCMSTLAB_LOCUS11974</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5104382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HNX7"/>
    <dbReference type="OrthoDB" id="297496at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015271">
        <property type="term" value="F:outward rectifier potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022841">
        <property type="term" value="F:potassium ion leak channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030322">
        <property type="term" value="P:stabilization of membrane potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003280">
        <property type="entry name" value="2pore_dom_K_chnl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013099">
        <property type="entry name" value="K_chnl_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003:SF325">
        <property type="entry name" value="POTASSIUM CHANNEL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003">
        <property type="entry name" value="POTASSIUM CHANNEL, SUBFAMILY K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07885">
        <property type="entry name" value="Ion_trans_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01333">
        <property type="entry name" value="2POREKCHANEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 12" id="KW-0407">Ion channel</keyword>
    <keyword evidence="5 8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="78"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="235"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="268"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="425"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="487"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel" evidence="11">
        <location>
            <begin position="233"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel" evidence="11">
        <location>
            <begin position="433"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="118"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="701"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="30"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="119"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="132"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF07885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAG5104382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="751" mass="81310" checksum="C4D3F46D9574E450" modified="2022-05-25" version="1">MMQISASDYYQRAPRSCSGGRRSSQLPTGVSSTAVTSASSNIPNNTDNSFRISTTVKASELWCCCCNCTTARSTKAPGFLACLGVCVLVFGYTLLGAFAFMALEGGFKTEPPPDIVRLSTGSSKPGSGKTSVNVASRDQTTQSPAILSGEDEETAEVRKLRASTVEKLWSITEDLNVLYKDNWTRLAEREILEFQEKMARSLNHDPRSSTFSVYGGTIQRSSRGGNDRYKGDKRWTFGGSLLYSLTLITTIGYGSVAPRTIWGRVITVVYALAGIPLMLVYLSTIGDVFARTFRRLYGRLCHRNTDCSKKQPSSGGQFLVPPPPMPGLIEKSYHRYDNHVETTKLGNFYSSKDSSCDELGVRATGGAILLDRDGLESNLYLHSASSANALQDMSTEKRHLHPCSQMSLMPSAVGYGTDTICVVRIPISLCLLIILLYVCAGTFMFHRLEGWNLLESSYFCFTSLGTIGFGDLVPTGRSASTKLLEELSLCACSLYILIGMGLIAMCFNLMQEEVVRVVRVFGRTCGTNGGITPGSSLAGATGLKSDLCGDASISIGGNILSDGCRQELDHEDDGRYSLPRKKTLTNDFARDTFGPAGSFSPTAHIQRGVSSFARNNISPLQHYSYQRGDGCHSQQDDPTNFEYFVPRSISEFNLSASSVQDIAIAPVPLPNSVLKPCSNLPICTSSQTKTTGTIVQSNNSCLGRSNTESTGNSGGGTLGTRSREKMVTFEDEGGSTPTRKNLAPTMENVFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HPC5</accession>
    <name>A0A8J2HPC5_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="16">CYP336F1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">HICCMSTLAB_LOCUS11688</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Microsome membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5103795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HPC5"/>
    <dbReference type="OrthoDB" id="2789670at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11056">
        <property type="entry name" value="CYP6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000182">
        <property type="entry name" value="Cytochrome P450 3A4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050476">
        <property type="entry name" value="Insect_CytP450_Detox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24292">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24292:SF104">
        <property type="entry name" value="CYTOCHROME P450 308A1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 13 14" id="KW-0349">Heme</keyword>
    <keyword evidence="10 13 14" id="KW-0408">Iron</keyword>
    <keyword evidence="12 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 13 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0492">Microsome</keyword>
    <keyword evidence="11 14" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="9 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="228"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="13">
        <location>
            <position position="455"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="non-terminal residue" evidence="16">
        <location>
            <position position="515"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CAG5103795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="515" mass="58693" checksum="417635FE27DE429C" modified="2022-05-25" version="1" fragment="single">MEIYCSIIAATIITIIIYSVIKYSSSKTNLKYDIACVPGKLPFIGHNLPIITMRSSFLYMFNIDFYHLFPNSSMMGYYNFSVPGIIVRDPKLIKQIMTTEFINFNKNTSSLDYNLDPLLSINPFFTSDDQWKKNRTILLNGLTSQKLKLIALGIINVADEFTNYLEQLITSSSSKSGAITVNALELLSRFTAQVVAIGGFGINGKSFNTEETETFESMVRPMLQPGSFYEFISIITFFFPFIAKILRVRFMPKKIYHYFVNIIKTVLEARSSGNQNPHNDFIEKVSELCRNEETGKIDEILVASHAASFFLDGYITSGVTLAFTAYQIAKHGEVQEKLRQHVIDILKKHDGKLTYQTLEDMKYMEQVIYESMRLFPALGYLGKVCTKETKLVGSDGVECCVKPGTEMIIPVFGLHRDQKYWDNPELFDPERFSPDNVGNLNKFVFLPFGGGPRQCVGMRVAIMQMKAALAMLVKDYWIEVDRKTDEPLRVHKLSGLFTAPHSDIWIRVCKLKDRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HPC6</accession>
    <name>A0A8J2HPC6_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">proteasome endopeptidase complex</fullName>
            <ecNumber evidence="3">3.4.25.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HICCMSTLAB_LOCUS11521</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Cleavage of peptide bonds with very broad specificity.</text>
            <dbReference type="EC" id="3.4.25.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="11">The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.25.1" evidence="3"/>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5103461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HPC6"/>
    <dbReference type="OrthoDB" id="7854943at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019774">
        <property type="term" value="C:proteasome core complex, beta-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004298">
        <property type="term" value="F:threonine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03762">
        <property type="entry name" value="proteasome_beta_type_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000010">
        <property type="entry name" value="Proteasome subunit beta type-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000243">
        <property type="entry name" value="Pept_T1A_subB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023333">
        <property type="entry name" value="Proteasome_suB-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194:SF0">
        <property type="entry name" value="ATP-DEPENDENT PROTEASE SUBUNIT HSLV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194">
        <property type="entry name" value="METALLOPROTEASE TLDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00141">
        <property type="entry name" value="PROTEASOME"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51476">
        <property type="entry name" value="PROTEASOME_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="8 13" id="KW-0647">Proteasome</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0888">Threonine protease</keyword>
    <keyword evidence="9" id="KW-0865">Zymogen</keyword>
    <feature type="active site" description="Nucleophile" evidence="12">
        <location>
            <position position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00026071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR600243-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAG5103461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="230" mass="24588" checksum="BDDF589372462D7A" modified="2022-05-25" version="1">MNIIQNFGPAMNFGSDSMASDWMNAEASTGTSIMACEFNGGVVIGADSRATTGAYISNRTADKLTKITDNIYCCRSGSAADTQAIADIVAYHLGFHQMELGTQPKVETAANVFREMCYNYRDSLVAGILVAGYDSQKGGQVYSIPIGGMCVRQPISIGGSGSTYVYGYVDAHYKPNMTKDQTVELITNTLALAMSRDGSSGGVIRLGIITEAGVERRVILGDELPKFWEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HPK7</accession>
    <name>A0A8J2HPK7_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HAT C-terminal dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS11701</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5103821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HPK7"/>
    <dbReference type="OrthoDB" id="7691576at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37162:SF1">
        <property type="entry name" value="BED-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37162">
        <property type="entry name" value="HAT FAMILY DIMERISATION DOMAINCONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5103821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="441" mass="51070" checksum="5E66A7721E7E5943" modified="2022-05-25" version="1" fragment="single">DLYEHVTSFFNEHNLNLQQCFAIATDGGSNLCGCNKSLYTLMKKKRDDLMLFKCICHSIHLVCSHASEELPSNIDYMLRETFNWFKRLALRRKKYLDIYNTISDGTDPLQMVHLSTTRWLARGQAVERILNQWDTLKLNFDFAATEPHQDRYVAKELQQMYNDPANLLYFTFLLPLLSEFNSINLLFQKEHADHFSILQELERFTLSLLRRVLHPSSVSLEVDLNFQSIYLPLQKVDFGYKFTALVNRLVKDTDISQTTVNNVKHRCQLFLIRACKELLSRTSGNTAILKKIRVFSPKICLKSDRPAFAELPLNLLKKGVDINASKVIKLTDSEGNYIFKDIASLALTAYRYSLPVSNASVERVFSRVTLTKTKLRNRMTLLLLSAILRIKMHLEENGICCTKFEPTDDMLNFNSTIYDKKKTDTSEEDENVEELLKNLNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HPR0</accession>
    <name>A0A8J2HPR0_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Similar to Dr: Muscle segmentation homeobox (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HICCMSTLAB_LOCUS12051</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the Msh homeobox family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5106008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HPR0"/>
    <dbReference type="OrthoDB" id="6159439at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048598">
        <property type="term" value="P:embryonic morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020479">
        <property type="entry name" value="HD_metazoa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050674">
        <property type="entry name" value="Msh_Homeobox_Regulators"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24338">
        <property type="entry name" value="HOMEOBOX PROTEIN MSX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24338:SF0">
        <property type="entry name" value="MUSCLE SEGMENTATION HOMEOBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00024">
        <property type="entry name" value="HOMEOBOX"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="3 7 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 7 8" id="KW-0371">Homeobox</keyword>
    <keyword evidence="5 7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="10">
        <location>
            <begin position="324"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="7">
        <location>
            <begin position="326"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="65"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="157"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="191"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="66"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="199"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="210"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAG5106008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="444" mass="48613" checksum="A5BD4CD411CC0BC4" modified="2022-05-25" version="1">MTVLRMTSSPMTSPSTSPSSPEHAQALEQASSRSSSSSTRQPLSFSVAALLADTKKTNNRQLQLVFDEKEKDKKDKKEGTCSSSSLSCPLVVSSKKLSVVYHPSPSSSPISSSSSSMVSYSSPTSQFHRQPLFPRISLLSSNNHKSFTTTVNSYYNNNNNNNNRNTHSPTDEIDGQDGVISDSSCNMFMVGSQSPISSSHEERQSRCSELDMEEDDDDDDEGCLVDVEDLEQQKSKSPTPVRPMPAYVTGFSTLGSILGLPASLHPSVWGTTGQTSHHRSVAATVAAAAAAAAASYFPSHFSHHAPLNEHGEPAKIKCNLRKHKPNRKPRTPFTTQQLLALEKKFRERQYLSVAERAEFSSSLHLTETQVKIWFQNRRAKAKRLQEAEIEKLRMSAVRQHHNSLYGGHHGLLGPAAALYPVGMLSHPAVGISPHHTVSPHSARE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HQ70</accession>
    <name>A0A8J2HQ70_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS11215</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5102850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HQ70"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5102850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="98" mass="11061" checksum="F1C12E01127D614B" modified="2022-05-25" version="1">MEICCLDQSETNANRDVVFHFNLNVLENEALTNTETLLLSQKSKSTVSTVNDTCLFNKLTGFVHVHKTHLNNIGTLQKDVKSEQKQFHCKKTAPSPRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HQA7</accession>
    <name>A0A8J2HQA7_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to IFT74: Intraflagellar transport protein 74 homolog (Homo sapiens)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS13002</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5107967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HQA7"/>
    <dbReference type="OrthoDB" id="444379at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030992">
        <property type="term" value="C:intraciliary transport particle B"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048487">
        <property type="term" value="F:beta-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035735">
        <property type="term" value="P:intraciliary transport involved in cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.400">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029602">
        <property type="entry name" value="IFT74"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31432">
        <property type="entry name" value="INTRAFLAGELLAR TRANSPORT PROTEIN 74 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31432:SF0">
        <property type="entry name" value="INTRAFLAGELLAR TRANSPORT PROTEIN 74 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="165"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="512"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="23"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="54"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="85"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5107967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="653" mass="75612" checksum="6011072FDC830538" modified="2022-05-25" version="1">MESIRPVTGGQMVAEKSATQWQRDVDVKTDNNLDRPKTSVSRPQTRHERPISRRGTQNQSTRNGSAFRAVTPSRSGTAARPPSASAYSNRGSTANSRVNNLTSAMGMNRLNTGLPPTSQMSSGVFDRPITQHGIAGMRPATTRGLPMTRQIQDKRYFEGLIQLKLRELNQEIGVIYSEIEAQKKERVTFAHYDNRAKELAAELTELQGQLADYNIVMDKVASNVNKDDMEEDVREIKASNERLALEIESLFEQRRFKEQKLRDMEERIEIEEKKADRMIEAMDSNLREAYDNLVEERNKLQSDIGNLQKEMDLLMSEKYNLEEQIALSSIKQEAVKLGINIAEAEEKRAKLLDEQKNKMSPDEEREHLLNRVKQDNMDIVAAERKIAETESKIRQVEQELEQLETDLEDNQSEKQIKYNELRKREEAIEQFMPNFEQSKEEELKKLSGLEDKIVESLRKLAYATDHDINQLSLNDEMAIFNIPSSENANKQDKSFEELSKEHIKLKQSLIKMESFEKKLNTEQIELTEKIKQKESELIVLEDLEGLKARSESDHEELIAQRQQLKIQQPEREKELSAVRREYEELKSKLEKNDLYLQISALDDKLEKLIQDNEQTIRSINESESQMNYQSLKEEAFVLLERYNSILKDNIKSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HQF9</accession>
    <name>A0A8J2HQF9_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Similar to PRTG: Protogenin (Homo sapiens)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HICCMSTLAB_LOCUS13880</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the immunoglobulin superfamily. DCC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5109244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HQF9"/>
    <dbReference type="OrthoDB" id="438268at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009653">
        <property type="term" value="P:anatomical structure morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098609">
        <property type="term" value="P:cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000299">
        <property type="entry name" value="protogenin isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44170">
        <property type="entry name" value="PROTEIN SIDEKICK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44170:SF59">
        <property type="entry name" value="PROTOGENIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 7" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035266488" evidence="7">
        <location>
            <begin position="18"/>
            <end position="1176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="984"/>
            <end position="1006"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="8">
        <location>
            <begin position="153"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="8">
        <location>
            <begin position="255"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="8">
        <location>
            <begin position="366"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="9">
        <location>
            <begin position="466"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="9">
        <location>
            <begin position="562"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="9">
        <location>
            <begin position="769"/>
            <end position="862"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="9">
        <location>
            <begin position="863"/>
            <end position="963"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAG5109244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="1176" mass="129623" checksum="CC512CA20D30F55F" modified="2022-05-25" version="1">MAARVLLFGILFTEVVLEPVCAAGGKGADNNLNGHKNGSKRDGLNFNLNKSTSQNLRIEPGGLIVLGKKGVTLNCLPGNNHDVSWLYNGESAPPCGVARCGILDNGSLHFYKKQNLQLAQKSSGRNETIDMSKKHEYRCIGRTASGGFLRSSPVFIQIADLSYTFKKSLINVTVHEGEITRLSCLIDSLPYPPNITWQHDGKPLLSDTKYIMVPPGVLYITATKQSDTGLYRCIATNDFIKKTKKSREAKLTVIPKLKLQELNIPVSLFPQSFYNYTLVKGSNLSLVCAVSGNPLLFLKWSFVPQRSDGANSAQSRILFNSTTGISVLELKNVSIFHAGTYLCSLENAASGVMEIQNITVDVTVPPTFIKKPSNQNCPNGKTARFECQAEGVPTPKIYWLKDAKNITINGGRKTIYIKENNKIELAISATVPSDSGDYQCVAVNSAGEIWAAGRLQVNASLNSPAAPTKLTCHTPSPVKISISWTPPESLPPSSITAYTVHYSPEGGGKEEVSPEPGNSTTVEVTKLLEPYTNYSFYVRVWNNNGASDQSATIVCATAPSVPKTAPKVMVDVLSSTKLNITWQPLTKKEARGVVIEYKIQWRLHEHPSYRVIFVPANVEHHLLTNLLPGAQYDLRVLARTEKGWPNISESLLGWNTVVMPTIDTDNYNIRNVLDVEIINMNASHLKMKWQVKEATFDTFKFDSWQIYCESVNGDKLFTALLDKNSTEYMFTNLEPNISYTVGLCIVTKGVSSDCILKIIKSIQYDSGNTPVALEANPLSPSSIQLTWAVVNKTSVDKYEVCYELVQYPDSNFSKCIFVNDTKAIIGELEAFTLYRFKVRSFQKDLNNSSQYSESIECYTSEDVPGKPEEVQVFQNGTKIRVVWKQPSKTNGIILTYFISYYSSDLVNSTLTWGNMTVPGNKTSVVLPDLPLGGRYYIMVQAATKAGYGRRSDPIYIFLGVSMSKTSTSSDKQKPPAKSKPDQSLGIILGVGISICFIMISLCSIYCRKKWEHSRSLRESAQPFKNRIFSRNSTTCCVEQSSTSVSQQVNNRIGCNEIELAVLCPSSPTSVNPQLDSKGVLSNGVEIGAKEPLLTSWNSNEENRDLHITENIQYKQSNSPVLKNQLGSEQDLNITELTTIDCTLNSSTNSLNNNLGCPTSSPKKITPPVIPVLEPNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HT88</accession>
    <name>A0A8J2HT88_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Similar to dyw: Circadian clock-controlled protein daywake (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HICCMSTLAB_LOCUS12965</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the TO family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5107893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HT88"/>
    <dbReference type="OrthoDB" id="8174700at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007623">
        <property type="term" value="P:circadian rhythm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.15.10.30:FF:000001">
        <property type="entry name" value="Takeout-like protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.15.10.30">
        <property type="entry name" value="Haemolymph juvenile hormone binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010562">
        <property type="entry name" value="Haemolymph_juvenile_hormone-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038606">
        <property type="entry name" value="To_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11008:SF39">
        <property type="entry name" value="CIRCADIAN CLOCK-CONTROLLED PROTEIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11008">
        <property type="entry name" value="PROTEIN TAKEOUT-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06585">
        <property type="entry name" value="JHBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00700">
        <property type="entry name" value="JHBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0090">Biological rhythms</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035211361" evidence="4">
        <location>
            <begin position="19"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00060902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAG5107893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="249" mass="28120" checksum="6534DF35D6909DB7" modified="2022-05-25" version="1">MSYCKLLIFLALLSISRCATEIPSFLKICHRNDLRLNECVNQSVEALKPYLSGGIPEFDVPPCEPLKIQKLNMHRSEGTVAIKSSNENIVIKGATNFVLKKVNVNLKKDQIQLEIFFPEFSMTSDYKINGKILMIPIKGEGQLTGNFSDINADIMIQGERYQNNIDNNTYYRICDVLIDFDVGNASVHLDKLFNGDQTLSSGMNLFLKDNWKIITEDIKPGIADNIADLLKKYSEKIFSKYSLDVLLPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MG99</accession>
    <name>A0A8J2MG99_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Similar to PK1-R: Pyrokinin-1 receptor (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HICCMSTLAB_LOCUS2622</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001117">
        <property type="protein sequence ID" value="CAG5078021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MG99"/>
    <dbReference type="OrthoDB" id="5950040at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008188">
        <property type="term" value="F:neuropeptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24243">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24243:SF208">
        <property type="entry name" value="PYROKININ-1 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="3 6" id="KW-0675">Receptor</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0807">Transducer</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="46"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="195"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="56"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="91"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="195"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAG5078021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="283" mass="31967" checksum="6B58E0A95F654390" modified="2022-05-25" version="1">MILLYNIFTYLSGVLYYVSTTINPILYNIMSNKFREAFKETLAKSCGSRSSGNLEQRSYSSLSRSQQRTLGGGNFGSRTTAGTGIGTGVGQDSSEGSGNSIRDENNLRMQTIITPVDSKPSDIMPVNLPSQRHSDDNYLIFNKKISKKYSTKSGNTELTVIESKNNCNDDDFDSEINDKNEKNTSRVMNGEMCHQRRLTDSNDDHDVSKRQGRGNNKSKYFGLRINNDKKWWRFFKWLPAGGVFKFTKNSRQNPGESAVSDIESNREEYSMTTCYIAGEHRLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MGT7</accession>
    <name>A0A8J2MGT7_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidase A2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS5730</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5090735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MGT7"/>
    <dbReference type="OrthoDB" id="6731322at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="205"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="456"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="614"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="205"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="229"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="251"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="351"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="390"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="467"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="533"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="558"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="643"/>
            <end position="666"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5090735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="752" mass="83965" checksum="5EE834428BA95C09" modified="2022-05-25" version="1">MKHRPISPIPITLVYSGNYQRFLIDTGGDVCLINASALKPETIIDIGKARRFRGLSDSTFETLGVDKLKILNIEVEFQVCREDLPFPGVGILGNNFLETEKAEISYDNQTLALLSRPTKIISFSLETTPSSNYTIPPRMKMVIAIPIQDFEKSEGYLPRMDLPDGVLGGEAVVKVEDGYATCMIINLNSNSVDIEIGPQILEEFEFDNPSSDSDESDDPLIENSSRIVNPEELRHKITEQYAEGLSYNPEGRQEPQKHPINDTTENHSLGLPISALPKTKKSNKKLSDEEAIQSVKRPGHPLGSKNRPRVSSAPEVRETIASRLKRRELGKTRVPPKINYRETGRLVINSEDPESQETADEEQGDDEVFLPVPISGPSTNNPTPDVGKEGDDEAEKDDETEKDNETTVPQKQRRKTRELVKMFDELLQKRPPSENIYTERALERIRREEAISNYTPQEYAEIKRTSSDTPKNIRQSLNKLPPLWRNEEDSLNEDTAPEINVDEFLRDNSDQSEEGSSNISPEETGGIEDPSETELPIIIEPEPSTSVNNVNTRNKNNLTPQNANRSRFTGYLGDGPEPRTPIFGRVLIPDELAAMGIRYDYASGQIVDENGKGVNETAETESADPNNTLIESERGRSSEKSPNISKLINSQNNNNKNKSRNNSENSSDPDKSDDRPTTSGNKTVGDDVGNHRFGPPFVAYDPPTFEEAEDIFAERHHRPKLSSPSSSDENVPPKSPEIKIKFSISRDGLTYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MII3</accession>
    <name>A0A8J2MII3_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Similar to Ccnk: Cyclin-K (Mus musculus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HICCMSTLAB_LOCUS3747</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the cyclin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5083152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MII3"/>
    <dbReference type="OrthoDB" id="25002at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20530">
        <property type="entry name" value="CYCLIN_CCNK_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20531">
        <property type="entry name" value="CYCLIN_CCNK_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000018">
        <property type="entry name" value="Cyclin-K (Predicted)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043198">
        <property type="entry name" value="Cyclin/Ssn8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10026">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21797">
        <property type="entry name" value="CycT2-like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0195">Cyclin</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin-like" evidence="4">
        <location>
            <begin position="36"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin-like" evidence="4">
        <location>
            <begin position="145"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="252"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="404"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="255"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="272"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAG5083152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="423" mass="47936" checksum="11906C5277CE6174" modified="2022-05-25" version="1">MPCWYYDKNELKQTPSIINDAIDYETECRYRQEGVRFIVNLGTSLNLIFNNTIATGVIYFHRFYMKHSFKQFPRYITACACLFLAGKVEETPKKCKDIIETSKILLTEQKFSLIFGRDPKDKIMTLEKILLQTIKFDLQVEHPYSYLLKYVKCLKGDKSKLQKKLQMAWNFVNDSLSTTLSLQWEPEIIAVAVMYLAGKLSKFEVVDWDGRQPNHLRWWDMFVEDVTMELLEDICHQVLDTYTLENNTLKEISQPTTPNSSSEPASSTPVSNDSTSTEPPEPRSNNYSEPQQGSTQPLQPAGAPAPLPSPSTGVQPNFTVYPPPTVYPAALPPVPATLPATTVPIQPSFTAYPPPPQVYQAPANMSVPPPLNPNMVPMHLPQPNYSVPPPAVPPPQYQYAYPTQIYYPPQNPPPNNRPYYPSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MIK2</accession>
    <name>A0A8J2MIK2_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Similar to CIB3: Calcium and integrin-binding family member 3 (Homo sapiens)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HICCMSTLAB_LOCUS6940</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5093604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MIK2"/>
    <dbReference type="OrthoDB" id="114727at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055074">
        <property type="term" value="P:calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007229">
        <property type="term" value="P:integrin-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051433">
        <property type="entry name" value="CIBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45791">
        <property type="entry name" value="CALCIUM AND INTEGRIN BINDING FAMILY MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45791:SF6">
        <property type="entry name" value="CALCIUM AND INTEGRIN BINDING FAMILY MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="6" id="KW-0401">Integrin</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="5">
        <location>
            <begin position="180"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAG5093604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="223" mass="25652" checksum="5BFAB34B42620215" modified="2022-05-25" version="1">MGNKIATFTEEQLEEYQDCTFLTRKEILRIFKRFREMGDPGKVPKTMTPELASQLKLPLSCLSKIPELKENPFRDRIAEVFTKCSDPGSEQNEEEEEGICFEEFLEMMSVFSEQAPRDLKRDFRNARDYRPPTVGSERQVLGHNPAYKTLLHFDEDGFVGMSDLERTCRQLVQDGLNEEEVGTVCKKILEECDIDGDGALSYLEFENVVAKASDFLSTFHIRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MJ73</accession>
    <name>A0A8J2MJ73_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similar to TMEM272: Transmembrane protein 272 (Homo sapiens)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS4297</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5085181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MJ73"/>
    <dbReference type="OrthoDB" id="6157510at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040350">
        <property type="entry name" value="TMEM272"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33444:SF2">
        <property type="entry name" value="MARVEL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33444">
        <property type="entry name" value="SI:DKEY-19B23.12-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="146"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="186"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="226"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5085181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="268" mass="30073" checksum="0768C547A83499D0" modified="2022-05-25" version="1">MAENHCDSRNEEIQNINPVATVQGHPSCNSIRQIGYVPCTPPPSYNNINLPPGHPANLISDRGAPPSYEEVIDRNAPPPSYDSLFGRMREAHKTSKGVFDFLLNIVVLLLGTIGCTIIIGVTIVVPVCMMIIGAVYLYDCPQGEYIPVYLLVGGGFGVFKQLLYLSARVRQRPEDRDEERIRQSPTLTLINCFTLGWFIIGSMWVYKEYEPNYDPSLGKYCNKTLYLFAFWLITLVYIFLGVITAGLCCISIATIIFQRRPPDRLVAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MJN7</accession>
    <name>A0A8J2MJN7_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Small ribosomal subunit protein eS21</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">40S ribosomal protein S21</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HICCMSTLAB_LOCUS4688</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Rough endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the eukaryotic ribosomal protein eS21 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5088032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MJN7"/>
    <dbReference type="OrthoDB" id="278325at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022626">
        <property type="term" value="C:cytosolic ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005791">
        <property type="term" value="C:rough endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1230.20:FF:000001">
        <property type="entry name" value="40S ribosomal protein S21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1230.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001931">
        <property type="entry name" value="Ribosomal_eS21"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038579">
        <property type="entry name" value="Ribosomal_eS21_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10442">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01249">
        <property type="entry name" value="Ribosomal_S21e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="6 10" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00035150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00035451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAG5088032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="125" mass="14383" checksum="18259F9AA48C965F" modified="2022-05-25" version="1">MEFIKNHFGAAEKNRRVSSTLTPDSWILSFETRLYRVSIVNNMENDQKEFVDLYWPRKCSSSNRIIHAKDHASIQLTLADVDPITGRMTDTHKMYAVCGSIRRMGESDDCIVRLAKKDGIIAKNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MK41</accession>
    <name>A0A8J2MK41_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS3245</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5081308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MK41"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035188253" evidence="1">
        <location>
            <begin position="23"/>
            <end position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5081308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="479" mass="53923" checksum="D015DF148F0ADE57" modified="2022-05-25" version="1">MAQGIFIIQTVLLIVAIFNASGADLGWNDRGTNLTYVGDKEIANTVLTSIQDGILHHFIVTKYKNKNNNKMILEKEVYTVHNPEGDHVQNITKYYDSTGTKVVSEDREITFFRDTTKIIDISTTTTEADGSKTEVYAKYEFPKGLPLVNKTGTYEYKYGPDNKLIKTIHNAIKTQGRLNEKTYEVTIVNDDGSKTQIGNVTILEGDKTITDVKVSNLDSKDEELISFWTYTIDNKSDNTKAVQTTNTTKNSDGSITTDLKIWRTYANGTRTREQVTTTKLNGELTSADYYPLEIEVEGVNPETKTPDSKITVVPPGYRPKDHERNTTKYYDSTGTRVAYEISESSFFYGTTKVTELSKTVMELDGSKTEIYAITEFPPELPPIRIIGTYKYAPSNKLTKSIRNIKTLNNGSEEDTDEVIVLNSNGSKTKRTTIRSSKDGFIIKDVTVVELDIEDKEISSNRTYVKYNRNDNTKVVEPTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MKW1</accession>
    <name>A0A8J2MKW1_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS3701</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5082988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MKW1"/>
    <dbReference type="OrthoDB" id="7705111at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="153"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="253"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="165"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="203"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="261"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5082988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="273" mass="30595" checksum="33E29806B998F8BA" modified="2022-05-25" version="1">MDFAIIQVTSGGKKVVQLQNIFLSDDDNKYTIRGTKDLIKQADNGRSKTLRVSINKKLIACTVIEISDDKDYLSSKIKSPMLGRGKRLKPVKRLNFSPGMMKDNSVPSRKVLSNRETNQAIAQKVKKIKIVQSKNVSQRERVIIERMRKKLKENAQTTEVEPDPVEPNPGEPNPVEPNPVKPIHNEPGTFTSIPSIGLPADNALSSGTSGNSNQQEKNDILIEKNSNGKDVAINNAELMKQLEKLRRENNLLLQKSRNLKRQSQVTRANHSEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MLL9</accession>
    <name>A0A8J2MLL9_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Peroxisomal multifunctional enzyme type 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HICCMSTLAB_LOCUS6499</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; fatty acid beta-oxidation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5092980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MLL9"/>
    <dbReference type="OrthoDB" id="3592703at2759"/>
    <dbReference type="UniPathway" id="UPA00659"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018812">
        <property type="term" value="F:3-hydroxyacyl-CoA dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd03448">
        <property type="entry name" value="HDE_HSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05353">
        <property type="entry name" value="hydroxyacyl-CoA-like_DH_SDR_c-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.129.10:FF:000013">
        <property type="entry name" value="Peroxisomal multifunctional enzyme type 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000185">
        <property type="entry name" value="peroxisomal multifunctional enzyme type 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.4290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002539">
        <property type="entry name" value="MaoC-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054357">
        <property type="entry name" value="MFE-2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051687">
        <property type="entry name" value="Peroxisomal_Beta-Oxidation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45024">
        <property type="entry name" value="DEHYDROGENASES, SHORT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45024:SF2">
        <property type="entry name" value="SCP2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01575">
        <property type="entry name" value="MaoC_dehydratas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22622">
        <property type="entry name" value="MFE-2_hydrat-2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketoreductase" evidence="11">
        <location>
            <begin position="26"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00073497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAG5092980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="626" mass="68202" checksum="0BA0D1D219BB10E3" modified="2022-05-25" version="1">MFIQFKTVSKLNQLVNTMSKLCFDERVVVVTGAGAGLGKAYALLFASKGAKVVVNDLGSSRHGDGASRVADTVVSEIKSQGGQAVANYDNVLDGDKIIKTAIDNFGRIDVLVNNAGILRDKSFARMSEDDWDIIQNVHVKGAMRATKAAWPYFKQQKYGRIIFTSSNSGLYGNFGQANYSSAKMALVGLANTLAIEGQSSGINTNVIVPTAGSRLTEDIVPADFYNQLKPELIAPVVAWLCHEDCTENGSIIESALGWAGKCHLIRSNGSILRKSLKDSLTPETVRDNWDQVTDMSTAKRCESIAEATGELMNVIEQLSSSKTSDSSSSRSFDPKYTIKYTYDVKDAILYALGVGATTKNPDDFQYLYENHENFSVVPSYFVIFGPLGALGSDMLVTALPNLGEINIAGILHGEQYLKVLKKIPTEANVETRFRIQETLDKEKMAVILIEHETIDVKSGEKLAVGQMAGVIKGAGGFGGPRNSDHEVPLIDAPKRNPDISVTQQTCVDQAAIYRLASGDMNPLHIDANISVMGGFERPILHGLCSLGFATRHILQTFARGDTELFDCVKARFVKPVIPGQTLRTDMWREGKRIHFQTIVVENNSPVISGAYIDLKDVKLGNQTSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MLN6</accession>
    <name>A0A8J2MLN6_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS6406</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5092859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MLN6"/>
    <dbReference type="OrthoDB" id="684045at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5092859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="72" mass="8310" checksum="AF926511092AD49C" modified="2022-05-25" version="1">MFYGDIGEKVFGNGKDEELLITKKKCYLVIAVGDKTFQAHKTILAPDSLFDAMHVLTRHERKQRKCNNHTRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MLP1</accession>
    <name>A0A8J2MLP1_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS7363</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5094037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MLP1"/>
    <dbReference type="OrthoDB" id="7615688at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5094037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="226" mass="26212" checksum="B3134666F5F1B313" modified="2022-05-25" version="1">MKTLPRLLEILVSARQLFSMEPVRQLFNVLQVIFRRIFIYIKDFIVNEFIPLIVDLNNFEVREEKIRYLTLSKQLFADLAAFFIIFALFATFLYFSTQCALENDHCAPAIDPQSENPPVVDLTEEENDRDSVFELLTLNHPRGDASTGPEKIIPRRKHQILRKSRPYCISTDNESSRSVISIKTTQSQHSQPVVVHPDIRSINPDGFNSWIVRRTRSGQIYGKYPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MLW7</accession>
    <name>A0A8J2MLW7_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Olfactory receptor 136</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HICCMSTLAB_LOCUS3900</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5083669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MLW7"/>
    <dbReference type="OrthoDB" id="6765072at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005549">
        <property type="term" value="F:odorant binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004984">
        <property type="term" value="F:olfactory receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004117">
        <property type="entry name" value="7tm6_olfct_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21137">
        <property type="entry name" value="ODORANT RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21137:SF42">
        <property type="entry name" value="ODORANT RECEPTOR 83A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02949">
        <property type="entry name" value="7tm_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0552">Olfaction</keyword>
    <keyword evidence="7 10" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="8" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="209"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="269"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="302"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAG5083669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="398" mass="46547" checksum="7CCFE5A4D6553FC4" modified="2022-05-25" version="1" fragment="single">MTEEDARLVEEEFKKVSSLLSWSETFLTIGGIWPLDKTYKRATFFTIYLTFQLIMEYGELLAVFGDLEAMVLSVLESVMQSLVYTKLIVFRYSVMLRSLIFTIKEDFEDTYYEDWVEKKIYLEYNALAKLFYKISMPYITVAATLYYLRPFLTYYVIMPLITDTSNLTFLVLPFRLKLFFSIETTQSYFIMYGYLSPMVYLLICHNAWICLLITMVLHICGQLAVLNHRIRHIPPDINEDKIQVVFGRLVRRHMRSIWMAKKLDDTFHFVLLIDLVGTTLLLGLMCYIVIIGSSMSESSFGYVYIICAIATVFLLYGYCIVGECLINESKKVNEAYYECLWYKSSQKFRKSLLICLIETQEPLRITAGKFFTFSLSGFTDVLKTAMSYLSMLRKMTQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MMU3</accession>
    <name>A0A8J2MMU3_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">phospholipase A1</fullName>
            <ecNumber evidence="4">3.1.1.32</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HICCMSTLAB_LOCUS7790</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 2-acyl-sn-glycero-3-phosphocholine + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18689"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="ChEBI" id="CHEBI:57643"/>
            <dbReference type="ChEBI" id="CHEBI:57875"/>
            <dbReference type="EC" id="3.1.1.32"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the AB hydrolase superfamily. Lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.32" evidence="4"/>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5095601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MMU3"/>
    <dbReference type="OrthoDB" id="199913at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008970">
        <property type="term" value="F:phospholipase A1 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013818">
        <property type="entry name" value="Lipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000734">
        <property type="entry name" value="TAG_lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11610">
        <property type="entry name" value="LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00151">
        <property type="entry name" value="Lipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00821">
        <property type="entry name" value="TAGLIPASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035276882" description="phospholipase A1" evidence="9">
        <location>
            <begin position="32"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="domain" description="Lipase" evidence="10">
        <location>
            <begin position="65"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAG5095601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="412" mass="46401" checksum="BA059D3C81B2B253" modified="2022-05-25" version="1">MTCNLFRGRMSSDKRVLFLTLVSIFFNLSNAESLIDHGSNSKNGSVHCFSKFGRGLEWFLGSKINPNLVEVKFYLTSRDNPIRTEVALGNNFQLDGTGFKIERRTVMIVHGFKSSGKKNWVYNMETAFRLWGDVNIVIVDWGEHANTVNYYKAAEHVMPVGRNIVKFLSHIINATSDSTQEKLDDLNWGPIHMVGHSLGAHICGIAADELKKKSLPWKVFRITGLDPARPCFLRSNLSLTKNDADFVDIIHTHGKSSSKFSFGMQEPIARSHFCLFISLGHVDFYPNGGKKQPSCSRTKKPWYARIKQKTCSHGLSHMYFTESLIAAAYNAGKFWSHEWDRSAQRAIEIIHETCDQNNCIEMGINAENYRNNDNPVLGTFFVITASSPPYYNVTADDLDNLEAQIVAGSAVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MMZ2</accession>
    <name>A0A8J2MMZ2_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS7955</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5095932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MMZ2"/>
    <dbReference type="OrthoDB" id="5953030at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5095932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="253" mass="29684" checksum="06CF5D6A68E149D8" modified="2022-05-25" version="1">MLLHNDLETINRKCKKNLLDVARTADTNDSVCLLVIPLHLYNHSIFTNKCYTRTLPRAKPPKPMQARANTWCVNPRGTLIVIRSMLILPRRYFTLDTYFHLEHDRLYFFGFTVQPITSSWFRTRILRMIRIFPTNLRLKSRNSLTSFFAADARGHSHVHVQGITGDGKISEIYNPSQNLFFFDIFIDESPDIRRSDRLATKYNNMNFKIPIFSTNSFEHSFTVTAIRLWRNLPIDVINALSLETFKIKAFEFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MNJ0</accession>
    <name>A0A8J2MNJ0_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">X-linked member 4 (Homo sapiens)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HICCMSTLAB_LOCUS8502</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the HSF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5097021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MNJ0"/>
    <dbReference type="OrthoDB" id="6418155at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000349">
        <property type="entry name" value="Heat shock transcription factor, Y-linked"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000232">
        <property type="entry name" value="HSF_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10015">
        <property type="entry name" value="HEAT SHOCK TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10015:SF465">
        <property type="entry name" value="HSF-TYPE DNA-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00447">
        <property type="entry name" value="HSF_DNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00415">
        <property type="entry name" value="HSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HSF-type DNA-binding" evidence="8">
        <location>
            <begin position="8"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAG5097021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="186" mass="22060" checksum="BDB680140872A726" modified="2022-05-25" version="1">MYEYNILLSTRFPQKLWKIINECQTGSIRWSLNGTTILLDYKKFHEEYLSPPQSIFKTNNISSFIRQLNLYGFRKVTSHNRDPSCNSRNPDIHEFLHDNFNRSRADLLSKVCRKTSGKLNKRIERAEAKNFPRNDVINKSRTQGMSRLQMCQLALKKALEQAIADYRRKKYQELKEIVPENHQDHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MNY7</accession>
    <name>A0A8J2MNY7_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Similar to TBCC: Tubulin-specific chaperone C (Bos taurus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HICCMSTLAB_LOCUS9241</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subunit">
        <text evidence="6">Supercomplex made of cofactors A to E. Cofactors A and D function by capturing and stabilizing tubulin in a quasi-native conformation. Cofactor E binds to the cofactor D-tubulin complex; interaction with cofactor C then causes the release of tubulin polypeptides that are committed to the native state.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TBCC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5099801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MNY7"/>
    <dbReference type="OrthoDB" id="194775at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015631">
        <property type="term" value="F:tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007023">
        <property type="term" value="P:post-chaperonin tubulin folding pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007021">
        <property type="term" value="P:tubulin complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1250">
        <property type="entry name" value="Tubulin Binding Cofactor C, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017901">
        <property type="entry name" value="C-CAP_CF_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016098">
        <property type="entry name" value="CAP/MinC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006599">
        <property type="entry name" value="CARP_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027684">
        <property type="entry name" value="TBCC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031925">
        <property type="entry name" value="TBCC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038397">
        <property type="entry name" value="TBCC_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012945">
        <property type="entry name" value="Tubulin-bd_cofactor_C_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15139">
        <property type="entry name" value="TUBULIN FOLDING COFACTOR C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15139:SF0">
        <property type="entry name" value="TUBULIN-SPECIFIC CHAPERONE C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07986">
        <property type="entry name" value="TBCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16752">
        <property type="entry name" value="TBCC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00673">
        <property type="entry name" value="CARP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51329">
        <property type="entry name" value="C_CAP_COFACTOR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0007">Acetylation</keyword>
    <keyword evidence="5" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C-CAP/cofactor C-like" evidence="7">
        <location>
            <begin position="170"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00026055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG5099801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="347" mass="39632" checksum="C44E10C261931EF2" modified="2022-05-25" version="1">METTEGTELGGVENLTDRISKRDRERRNVIERRREEKQQLAVESEQLSFFQDTFHLHCEKVKELLDTAPAAQTSTLPGIFDKVNKEILTLWNYLSQSKIFLKMYDIRRAQESLQQLETEAAELELKLLPKKKFGFKNRRPAKKPSEKSLDVTDGLKNLNLSETVTTNGATKQHNELISKYTDSASSLIGKSDGTFALDAENVNKNDVLLSDLTRCIVRIYGAPSTVHMINLKQCQVLIGPVSSSVFANNCDSCTFAFACQQLRLHSSTDCTIYLHVTSRAIIEDCVKIKVAPYNWSYEDQQSHFNLSGLDIKTNNWDSVDDFNWLSYEKHSPNWAILKPELRVKFRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MP86</accession>
    <name>A0A8J2MP86_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Similar to SNTA1: Alpha-1-syntrophin (Homo sapiens)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HICCMSTLAB_LOCUS10495</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5101593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MP86"/>
    <dbReference type="OrthoDB" id="409749at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016010">
        <property type="term" value="C:dystrophin-associated glycoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015482">
        <property type="entry name" value="Syntrophin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055108">
        <property type="entry name" value="Syntrophin_4th"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10554:SF12">
        <property type="entry name" value="IP02644P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10554">
        <property type="entry name" value="SYNTROPHIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23012">
        <property type="entry name" value="Syntrophin_4th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Syntrophin C-terminal PH" evidence="3">
        <location>
            <begin position="97"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG5101593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="203" mass="22106" checksum="295FCBAF32266CE4" modified="2022-05-25" version="1">MAREKNFPPQITSGSPAGLMKMKIKFLEGLVGSSTRNNEPGSSGSSNSGTINGATFAVRVGTIDGVITHHLRAETRRDLVAWARAIVQGCHTAALSLREYTVRCLWQGRPCKLVVNTEEGFMLYAAGARGINGASPGSPPAPLWKRSFDKLRMSADDGSRLLWLDFIDDENEIELDLESCPKPIVFVLHNFLSAKIHRLGLSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MR17</accession>
    <name>A0A8J2MR17_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">E3 ubiquitin-protein ligase</fullName>
            <ecNumber evidence="10">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HICCMSTLAB_LOCUS10799</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 10">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8 10">Belongs to the E3 ubiquitin-protein ligase UBR1-like family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="10"/>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5102006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="26387at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000151">
        <property type="term" value="C:ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071596">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process via the N-end rule pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd19672">
        <property type="entry name" value="UBR-box_UBR1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.30:FF:000001">
        <property type="entry name" value="E3 ubiquitin-protein ligase UBR2 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2670">
        <property type="entry name" value="E3 ubiquitin-protein ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003769">
        <property type="entry name" value="ClpS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042065">
        <property type="entry name" value="E3_ELL-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044046">
        <property type="entry name" value="E3_ligase_UBR-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014719">
        <property type="entry name" value="Ribosomal_bL12_C/ClpS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039164">
        <property type="entry name" value="UBR1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055194">
        <property type="entry name" value="UBR1-like_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003126">
        <property type="entry name" value="Znf_UBR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21497:SF24">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE UBR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21497">
        <property type="entry name" value="UBIQUITIN LIGASE E3 ALPHA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02617">
        <property type="entry name" value="ClpS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18995">
        <property type="entry name" value="PRT6_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22960">
        <property type="entry name" value="WHD_UBR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02207">
        <property type="entry name" value="zf-UBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00396">
        <property type="entry name" value="ZnF_UBR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54736">
        <property type="entry name" value="ClpS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51157">
        <property type="entry name" value="ZF_UBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 10" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="7 10" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="UBR-type" evidence="12">
        <location>
            <begin position="100"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="UBR-type" evidence="9">
        <location>
            <begin position="100"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="994"/>
            <end position="1027"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1066"/>
            <end position="1088"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="994"/>
            <end position="1013"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1014"/>
            <end position="1026"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1066"/>
            <end position="1082"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00046341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU366018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAG5102006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="1784" mass="203092" checksum="DCB756CDA59AA970" modified="2022-05-25" version="1">MDDVELSPVLPVFRNSNRPCVNVWMDKMSKGILTSTHFKEHWRIWVPKIYSPELNGNCLTWSFNESSAQNMLYNTLEEFICNGDPREVLDQLRKMDKPPSVCGKFFKVGEPTYICRECGMDSTCVLCVACFKESAHQNHKYKIGTSHGGGCCDCGDTEAWKKDPFCNIHLAGLKYKESSENKLPEDIVERATATFEAVLKYCYELLSLDHNPNLPADLSVKETDEDPLSLLNTNGNYCTVLFNDETHTFEQVISTLVRVLKCSQKEAIEFVTNIDRNGRAVVKCSDFQHCSELKSEIERFTLRLNSQPLKVHVVHAHVIAHQIFAMKLLDWLQQFMNHCEGFRIIFSDVALNTKLPDVSIVQGILNRDSQLWKAARTAWHRLFISGMLMEYESKKALAIIFTKNYGDVLKEFIRDDHDHSFSISSMSVQLFTVPTLAHLLIAHHDALFILINTFMSESSRRCNSAGKLEFERNVPNTSFKRAIFILADLLYLLSSKPDTWTDELRKGFIHGVSFLLKLLWSMQLMNPVLRQVSQHMEYEPEWESAFNLQVKLSPVISLTLDWCGSDRTVLIKTFRQVLKKLAERSENETSPPRIIRELAEHSASCIQYDVSSESVSIHLPISRFLAGLFLYLEKYDLNFNSSEITIPNRLTMEQIIEPVLRTQAMIAQVHAGMWRRNGYSLLNQLYFYHNVRCRSEMLERDINLLQVAASLIDSDEFLIHIINKFNLINWADPDFETNTLKNPEEDSIRQTINLVEELLGLLIIIIGERHVPGVGRVTADDRLKKEIIQQLCIKPMSHSELSKTLPEGALYESGLERVINDVADFNKPAQNSAGKRLYELKSHLYSEYNVFFYHYTKEELSKSEEAQRKRRKAMGELECCPPPQLPRLTESFSLVANLLQCDVMLHIMQTVLERARNLRARSFSEPQIHKIIHLIGYALQEQMTGYYPFLNFTERAAKKNIFNLLEELLTSPRIDAHKDLLTWALEKYREATGSTIPQSEVSADSSQASNPSASDKDPAKNSKEWRTQMAAQKRTKVMALMAAMQKNFMKKNAKLFENTVLDVNNKSNEHGSSMDLSESLEQSPVAMGPKQTPRLAEEKTYTCILCQEDQTVSITGDAMVLAAFVQQSTVLCQDRDDINETNPLYLSSKLGASPHTSTCGHVMHAYCWQTYFDNVLAKENRRPYRLRQPASFDVEKQEYLCPLCECLSNTVLPLLPSLATLHPTKANRINIDFETWLDALRVTLNCREKTNITEITDLAMENNHESICRYCKNSNFQHSTDDSSSKVDTIACPIRKIYKEMGKEVAAAFELKSPEPEIRLSDHLISMIHLFAQTTYTKGLGVEPHEEDSRVPLLAFKSTAYTVHAIEFMLRDSEKPLLGSLPSRLRDSLDCLARTSAILGHTWSPYSDHARRRDFGTHALTLLSLLIENPHNESCFTEWDPFGILVPLLVTFPSLFAINPDRSPPIITGDNHESHLLKLVFLALVTKIIATSDFESNEAMDVDFSEETIEENSDDENCDALLALMDGINIKTGSWTLNQIWKKIKEASLPFLRCCTLYIHYITDVPAPLELTNKGGDNYENICAYLGLPTTCDGLLNSESVRTLAKKWMEHPRARLPVKVKEPLKVNSLVELPEDYSELINLVSLFTCPTSDREDSRNPTMCLVCGEMLCSQSYCCQSELNKTTVGACNYHSSVCGAGIGIFLRVRECEILFLRSPSRGAFTCPPYIDEYGETDQGLKRCNPLSLCKKKYKQLNQMWLGHGLHEAIARSLESSSNLISNQWQHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MSP0</accession>
    <name>A0A8J2MSP0_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein-lysine N-methyltransferase HICCMSTLAB_LOCUS12944</fullName>
            <ecNumber evidence="5">2.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HICCMSTLAB_LOCUS12944</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="5">S-adenosyl-L-methionine-dependent protein-lysine N-methyltransferase that methylates elongation factor 1-alpha.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the class I-like SAM-binding methyltransferase superfamily. EFM5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="5"/>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5107839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MSP0"/>
    <dbReference type="OrthoDB" id="206354at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016279">
        <property type="term" value="F:protein-lysine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03187">
        <property type="entry name" value="Methyltr_EFM5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019369">
        <property type="entry name" value="Efm5/EEF1AKMT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041370">
        <property type="entry name" value="Mlase_EEF1AKMT1/ZCCHC4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13200">
        <property type="entry name" value="EEF1A LYSINE METHYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13200:SF0">
        <property type="entry name" value="EEF1A LYSINE METHYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10237">
        <property type="entry name" value="N6-adenineMlase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5 6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAG5107839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="216" mass="24827" checksum="4F36322C7AFBF426" modified="2022-05-25" version="1">MTDSDDEVPQLSGAALAALEEFYAERREREEQVNKTLTNVNNQTPDIVFDEDWQLSQFWYDDETVDTITKAALRITDKNGKIALISCPTLYRALKKNAGSRQIKIFEYDTRFSVYGSDFIPFDYKFPLHVPKEMASDFDLVIADPPFLSEECLTKTAVTIKFLSKKNILLCTGSMMADLAERLLNVNKCDFQPHHKNNLANEFSCYANFDFDKFLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MT80</accession>
    <name>A0A8J2MT80_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Similar to Rsf1: RNA-binding protein Rsf1 (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HICCMSTLAB_LOCUS13265</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5108493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MT80"/>
    <dbReference type="OrthoDB" id="5970at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050907">
        <property type="entry name" value="SRSF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23147">
        <property type="entry name" value="SERINE/ARGININE RICH SPLICING FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="7"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="75"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="186"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="87"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="129"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAG5108493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="238" mass="25032" checksum="B912E6243478702C" modified="2022-05-25" version="1">MTPEGYTRVYVGGLTETIKKEDLQTEFEKFGKLNKVWVAFNPPGFAFIEFLRVDEAELACSSMNGTEILGTKLRVEISRGPGRSRNRGGGGGGGGGFRGQSGGGRGGFGGSRRSYGGGGAGGGYHRDNNSYGNQGGNSNSYHSGRAGGGGPKYSSRGRYGGDNNYSGGRNNSGYMAGGNSYSQGYNNSSGNGDASVDYYNRRNKDSSGASSRYRNRSPAGRGSTLNCLLNLRIAKYGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MVV7</accession>
    <name>A0A8J2MVV7_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Uridine 5'-monophosphate synthase</fullName>
            <ecNumber evidence="5">2.4.2.10</ecNumber>
            <ecNumber evidence="6">4.1.1.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">HICCMSTLAB_LOCUS10223</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="pathway">
        <text evidence="2">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 1/2.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">In the C-terminal section; belongs to the OMP decarboxylase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the N-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.10" evidence="5"/>
    <dbReference type="EC" id="4.1.1.23" evidence="6"/>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5101150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MVV7"/>
    <dbReference type="OrthoDB" id="10263753at2759"/>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00119"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004588">
        <property type="term" value="F:orotate phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004590">
        <property type="term" value="F:orotidine-5'-phosphate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd04725">
        <property type="entry name" value="OMP_decarboxylase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000114">
        <property type="entry name" value="Decarboxylase,orotidine phosphate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2020:FF:000025">
        <property type="entry name" value="Uridine monophosphate synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01208">
        <property type="entry name" value="PyrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014732">
        <property type="entry name" value="OMPdecase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018089">
        <property type="entry name" value="OMPdecase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001754">
        <property type="entry name" value="OMPdeCOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023031">
        <property type="entry name" value="OPRT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004467">
        <property type="entry name" value="Or_phspho_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00336">
        <property type="entry name" value="pyrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01740">
        <property type="entry name" value="pyrF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19278">
        <property type="entry name" value="OROTATE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19278:SF9">
        <property type="entry name" value="URIDINE 5'-MONOPHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00215">
        <property type="entry name" value="OMPdecase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00934">
        <property type="entry name" value="OMPdecase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="Ribulose-phoshate binding barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00156">
        <property type="entry name" value="OMPDECASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="8" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="12" id="KW-0456">Lyase</keyword>
    <keyword evidence="13" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="11" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Orotidine 5'-phosphate decarboxylase" evidence="16">
        <location>
            <begin position="244"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="active site" description="For OMPdecase activity" evidence="14">
        <location>
            <position position="303"/>
        </location>
    </feature>
    <feature type="active site" description="For OMPdecase activity" evidence="14">
        <location>
            <position position="305"/>
        </location>
    </feature>
    <feature type="active site" description="For OMPdecase activity" evidence="14">
        <location>
            <position position="308"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="250"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="272"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="365"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="422"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="441"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="442"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00015047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR614732-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR614732-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CAG5101150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="470" mass="51831" checksum="496D6BAC0CB26B24" modified="2022-05-25" version="1">MESELKNLAVMLFDVGAIKFGEFITKVGLKTPVYIDLRVIISYPKLLNQISNILWKLADDVDKIDQICGVPYTALPIATLISVDSNIPMLIRRKEAKSYGTKKLIEGKFAAGDNTVIIEDVVTSGSSILETVKDLKQESLNVTAALVIMDREQGGRKNIEDSGIKMKSLYTMTKLMEYLQEAGKVTQDTVDGVLKYLAECLAPVKTLEKEGNDRLKMDFLSRSKLAKSQIAAKLLQLMDMKETTLCLAADLTKADEIVDLVKLAGPHIAVLKIHVDIIEDFNQDFINQLKNLSEKHKFLIMEDRKFGDIGNTVSLQYSKGVYKIAEWADLITVHPVAGPGILDGLKNALKNITDERGIFLITEMSSKGALTTGDYTKQTLTMAETSDLVVGHVCQSNIFLNPGLVQLTPGVKISKASDDLGQQYNTPEAVVNSGADLAVVGRGITEAADKLREVINYKNQLWTAYKNRIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MW32</accession>
    <name>A0A8J2MW32_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS10314</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5101241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MW32"/>
    <dbReference type="OrthoDB" id="5957963at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="130"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="150"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="192"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5101241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="223" mass="24755" checksum="0A680FACEDA36CCE" modified="2022-05-25" version="1">MFGSKSTRKNLSTIIQDDEKYLGAKEGLHNLLPKWFFVLRNDSWCELMDSLLDPLQNAPLNKHLAYVLIDQIVLTLFPELSRPQSILNITKELSNNKSHEPVEETSAASSDTLDLRQPADGVDPGGVVDLHVEVDSEDEGSKTHGNAGDQEQHSPAKSVDNQRADEDSDHLHGSNDDCRYAGVQGASSGFEDGARVENNRVDSAELLEEHQPESDHQSLNRRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MZA3</accession>
    <name>A0A8J2MZA3_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Gustatory receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HICCMSTLAB_LOCUS12569</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Cell membrane</location>
            <topology evidence="1 8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the insect chemoreceptor superfamily. Gustatory receptor (GR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5107067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MZA3"/>
    <dbReference type="OrthoDB" id="6366728at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030425">
        <property type="term" value="C:dendrite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043025">
        <property type="term" value="C:neuronal cell body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007635">
        <property type="term" value="P:chemosensory behavior"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008049">
        <property type="term" value="P:male courtship behavior"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050909">
        <property type="term" value="P:sensory perception of taste"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013604">
        <property type="entry name" value="7TM_chemorcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21143:SF104">
        <property type="entry name" value="GUSTATORY RECEPTOR 8A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21143">
        <property type="entry name" value="INVERTEBRATE GUSTATORY RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08395">
        <property type="entry name" value="7tm_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 8 9" id="KW-0675">Receptor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="23"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="63"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="104"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="159"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="192"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="279"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="306"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="386"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAG5107067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="411" mass="47521" checksum="6D9D309B903CC544" modified="2022-05-25" version="1">MMELLNLKEKFNLYRYNLVCRRYYIIIQYIFYKLIGLSPWVVDTSAILSKNLNHIEEINLCEISYVGSYYNLCIFSFIGLSNIYFELNSSLPHAQSDSILTPAFRARLKFIAILCINFIPLIYVCRQKILIAVINRLKTTDQKLKKCENYLSNKNNKHIYFIFMVKFLCSATSTSILLHHSNFSFVTLLLRIYPDFIGGWVMIQFSTLLKVINKRFKSINATITKLDNIVNDPNQIKVLSEKEVSFRHETEIIKHAYVELCEVCDNVVDFYGLPLLISIIHYLTINIIRLYFIILSVLSIASYDRVIYICNGINFSLASFIFLILTSSVTATMKESKKTLKVISLLVNRCPVDSKIEKQLTKFSSDISHFQVEFTACDVIPLDRRLLLMIVGTIASYLVIVVQFRINSPSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2N059</accession>
    <name>A0A8J2N059_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Gustatory receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HICCMSTLAB_LOCUS13327</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Cell membrane</location>
            <topology evidence="1 8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the insect chemoreceptor superfamily. Gustatory receptor (GR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5108618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2N059"/>
    <dbReference type="OrthoDB" id="6366728at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030425">
        <property type="term" value="C:dendrite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043025">
        <property type="term" value="C:neuronal cell body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007635">
        <property type="term" value="P:chemosensory behavior"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008049">
        <property type="term" value="P:male courtship behavior"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050909">
        <property type="term" value="P:sensory perception of taste"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013604">
        <property type="entry name" value="7TM_chemorcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21143:SF133">
        <property type="entry name" value="GUSTATORY AND PHEROMONE RECEPTOR 32A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21143">
        <property type="entry name" value="INVERTEBRATE GUSTATORY RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08395">
        <property type="entry name" value="7tm_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 8 9" id="KW-0675">Receptor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="36"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="76"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="119"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="154"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="235"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="264"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="331"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAG5108618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="358" mass="41362" checksum="CA121E23E085160C" modified="2022-05-25" version="1" fragment="single">MAILNNIRPLLVGARIFGCTPHRITDRELIITNFGLVYSLFIAVIIGCICIFDFYINVYHTIEFKMRLLIFLRSCLYYISILTDGVITTIWNGFLNIIVSRIYNFDYATKYNQNSNYKMINTCKFIIITVLVYWTAVGYFTYLCEKSDFIFNAVAYSVVNVTMSMQIIKFIGLLLLLYQRFNYLDQMVLQSDVKRGLTVIVYPERGNMNLQEICWLHYLLVTASEEINSVYSTQLFFWITISFLNGLSRIYTLTTMKAEQKLYLVIRDSFSVVACAVNLFAISAFSHFTAARANNIRKSTFAPQASIRMKKNFDNFEVIAYFYLKKLRFTAAAGLIRVDLPLLLSIIGAITTYLVILH</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-24" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>B9W4K6</accession>
    <name>B9W4K6_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cc_PmNVorf87</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">Cc50C22.5</name>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS5449</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2009" name="Science" volume="323" first="926" last="930">
            <title>Polydnaviruses of Braconid Wasps Derive from an Ancestral Nudivirus.</title>
            <authorList>
                <person name="Bezier A."/>
                <person name="Annaheim M."/>
                <person name="Herbiniere J."/>
                <person name="Wetterwald C."/>
                <person name="Gyapay G."/>
                <person name="Bernard-Samain S."/>
                <person name="Wincker P."/>
                <person name="Roditi I."/>
                <person name="Heller M."/>
                <person name="Belgahzi M."/>
                <person name="Pfister-Wilhem R."/>
                <person name="Periquet G."/>
                <person name="Dupuy C."/>
                <person name="Huguet E."/>
                <person name="Volkoff A.N."/>
                <person name="Lanzrein B."/>
                <person name="Drezen J.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5089984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FM212911">
        <property type="protein sequence ID" value="CAR82243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B9W4K6"/>
    <dbReference type="OrthoDB" id="7678208at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="514"/>
            <end position="537"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5089984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAR82243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="780" mass="90170" checksum="532A45E6EAC47C58" modified="2009-03-24" version="1">MMQKKNQFKIIKPFCLILLLVTITQILYTLVKEAYFVKMKHLLRLLKDSSLEDSNQLYDSIAILANYDTPWLTNDDMMFLTTSQFNNISLYKLFIHIENIKSVTDDAFFKEIDTLILENFGDNELRELKITSMTNLHIVNTLIIALLTIPINTFTINISKTKFSPEKCLENSLPISPLKMLLKNPALLDANDAIHKSYRCEKKIDSIDIYVGPPVHYDDFTNLLCVLLKIPSNDLWLSSHKNHGYKTQMIIVNNLRIINTELNDPKVSEIIESLIKLQVFKIQDIKTTVESALSALHHNQLYNQNNSENAATSNEKFEMSNIPAQLRTPLQHILLISYTFKSEKELSLNNLDSAVLAALNHELIDLKIDISYSPLSSLLNSSLPPDIEICDNLDRGTVKSILASYNNFQNNMPLIQLSTIACPLIYKQFIAIFPFYNGNIINIIKCNEVSELNCDGSYDVVSLCPHPTYNRSYISNTVIKKLELLISFCEFDGNYSKFENIINLIPFDIDDMPYIMTIMFSMTNIVYVTVCAAVYTYHMSIFKHYHVQSMYRLTSILGPDAYKLVLNNNINLPPIQEQTSQLHLMSINALFPAQLHLANVPLDELDNTIKNDNNVNNDKLNKHFSKTYPEYIVWLYLLSLTNAHKERDDDLIKRENYLLMMLRNTVENLNELHYIKHKLQHNVSELNTKFSVRTSYQMIDFNNNDVDIEETHGTGNEITEEMTDRVNRQPEQHDVGIIYRYLINNKCNLQNDVWGLLYFMLRTKNVDDFIDCIKCYVDDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2E2B9</accession>
    <name>A0A8J2E2B9_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Phosphoribosylformylglycinamidine synthase</fullName>
            <ecNumber evidence="3">6.3.5.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Formylglycinamide ribonucleotide amidotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Formylglycinamide ribotide amidotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">HICCMSTLAB_LOCUS1286</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="pathway">
        <text evidence="1">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the N-terminal section; belongs to the FGAMS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.3" evidence="3"/>
    <dbReference type="EMBL" id="CAJNRD030001116">
        <property type="protein sequence ID" value="CAG5075127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2E2B9"/>
    <dbReference type="OrthoDB" id="6666987at2759"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00128"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004642">
        <property type="term" value="F:phosphoribosylformylglycinamidine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd02203">
        <property type="entry name" value="PurL_repeat1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02204">
        <property type="entry name" value="PurL_repeat2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.10:FF:000026">
        <property type="entry name" value="phosphoribosylformylglycinamidine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.650.10:FF:000024">
        <property type="entry name" value="Phosphoribosylformylglycinamidine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.10:FF:000007">
        <property type="entry name" value="Phosphoribosylformylglycinamidine synthase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.750:FF:000001">
        <property type="entry name" value="Putative phosphoribosylformylglycinamidine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.750">
        <property type="entry name" value="Phosphoribosylformylglycinamidine synthase, linker domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.650.10">
        <property type="entry name" value="PurM-like C-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.10">
        <property type="entry name" value="PurM-like, N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00419">
        <property type="entry name" value="PurL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040707">
        <property type="entry name" value="FGAR-AT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055181">
        <property type="entry name" value="FGAR-AT_PurM_N-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010073">
        <property type="entry name" value="PurL_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041609">
        <property type="entry name" value="PurL_linker"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010918">
        <property type="entry name" value="PurM-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036676">
        <property type="entry name" value="PurM-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036921">
        <property type="entry name" value="PurM-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036604">
        <property type="entry name" value="PurS-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01735">
        <property type="entry name" value="FGAM_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003672">
        <property type="entry name" value="PRK05297.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10099">
        <property type="entry name" value="PHOSPHORIBOSYLFORMYLGLYCINAMIDINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10099:SF1">
        <property type="entry name" value="PHOSPHORIBOSYLFORMYLGLYCINAMIDINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02769">
        <property type="entry name" value="AIRS_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18072">
        <property type="entry name" value="FGAR-AT_linker"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18076">
        <property type="entry name" value="FGAR-AT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22689">
        <property type="entry name" value="FGAR-AT_PurM_N-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13507">
        <property type="entry name" value="GATase_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01211">
        <property type="entry name" value="GATase_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109736">
        <property type="entry name" value="FGAM synthase PurL, linker domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56042">
        <property type="entry name" value="PurM C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55326">
        <property type="entry name" value="PurM N-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82697">
        <property type="entry name" value="PurS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51273">
        <property type="entry name" value="GATASE_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosphoribosylformylglycinamidine synthase N-terminal" evidence="16">
        <location>
            <begin position="38"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphoribosylformylglycinamidine synthase linker" evidence="15">
        <location>
            <begin position="176"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="domain" description="PurM-like C-terminal" evidence="14">
        <location>
            <begin position="437"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="domain" description="FGAR-AT PurM N-terminal-like" evidence="17">
        <location>
            <begin position="663"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="domain" description="PurM-like C-terminal" evidence="14">
        <location>
            <begin position="849"/>
            <end position="970"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008608"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00029823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00032632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00071729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF18072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF18076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF22689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="CAG5075127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="1255" mass="136473" checksum="DE83C7BEC7B36162" modified="2022-05-25" version="1">MAITRLYKSSGLLSGQLASKLASLQQVNPCITELRTETCFYIESSRPLTSEDLKIVTFALTSPFDPQLFQETQLSAPPGSTVVEIGPRLNFSTAFSSNAVSIFKSAGLSHVSRVEKSTRYLVDVPESSEDFGRIIDALHDRMTECRYRSPIETFDHGFRPEPWFEVDILQNGRKALEDVNSKLGLAFDDWDLDFYTDLFKTKLKRNPTSVECFDLAQSNSEHSRHWFFRGKLVIDGVAEPQTLFDMIIGTQKSSNPNNVIKFADNSSAIQGFKVPTLVPGTTWEPSAFQMTEVERHLIFTAETHNFPTGVAPFSGATTGTGGRLRDIQGCGRGGHYIAGTAGYSVGNLFIPGYNLPWEVPADYPSNLASPLDIIVEASNGASDYGNKFGEPVISGFARTFGMKTGNSRVEWIKPIMFSGGCGTVDAGMIDKKVPERGMQVAKIGGPVYRIGVGGGSASSVAVQGTQSADLDFGAVQRGDAEMEQKLNRVVRGCTELGSRNPILSIHDQGAGGNGNVLKELVEPAGAVIFFEKFDLGDPSISVLELWGAEYQENDAILCDESSVALIQQIATREKCPVNFVGTVTGSGRIVLSQEKVPDVAKHLEGRDDGKHPVDLDLEFVLGKMPQKTFASNRLPEERHPLELGKISVLEALERVLRLPSVGSKRYLTSKVDRCVTGLVAQQQCVGPLHTPLADVAVTAISHFSTSGIATSIGEQPIKGLVDIKPGARMTVIEAISNLVFAKISSLKDVKCSGNWMWAAKLDGEGAKLFDACSAMCDLMSDLGIAIDGGKDSLSMAARVGSEVVKSPGTLVVSCYAPCPDVRKVVTPDLKGPTLRKTTYLVYVDLSHGKSRLGGTALAQVYNQLGSEVPDVEDPQEVVRAFETTQKLIAEDKVLAGHDVSDGGLLTCLLEMAFAGMAGIDIKIVHKGNQVLDVLFSEEVGWILEVEDLETTLKTFASNSVPAFTVGKTTNLGLREKITIEVAGQQVLHESVFRLMRTWEETSAQLEKRQSNVSCAEEEFLGLETRKVPIAKLTFDPDCWVPKQTTVRVAVIREEGINGDREMAAACIQAGFETWDVTVTDLLNGQVTLDRFRGVIFPGGFSYADVLGSAKGWAASLLFHPDLSKQLDGFRRSTDTFSLGVCNGCQLMSLLGWVGSDSIQNDPQVLLEHNKSERFECRWSSVKIESSKAIMLRGMEESVMGVWIAHGEGKFTFKEKILDKMAAQKCVALKYVDDDGTPTEKYPMNPNGSKARGVQC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2E9Z1</accession>
    <name>A0A8J2E9Z1_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS245</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001114">
        <property type="protein sequence ID" value="CAG5073252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2E9Z1"/>
    <dbReference type="OrthoDB" id="10345495at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5073252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="753" mass="87728" checksum="E9586D25CF279032" modified="2022-05-25" version="1" fragment="single">NDVGDYKYNHINDTLINECEIVTIKLDEDSRRAFRLSILSNETVIESLYFHKTDGLLARSETPVYLTDRDSLKKMCGAKIYKDYKFIKTSFEEYVPDMGDFRFYHNYNRTASLVKLKPEDTFVDTSTLSYNLYAPDLEVVNCKLFVILHPNSIIDKPRIELMRTILMFYNHLDMFFGNFTSPKIRLTLKGILFPDIGQKIPYEGNRLDLQLLNWSEIDKALMKFVKEKKDYFQLDTHDKVYFLSQTSYVREPDGEICNDPPMPRIAAVIHGDLLTYHIIHLQYLAKMFGGQFVQPCESLPGILYHRNRQMNPPLFVWSSCTISGFSTYFNENECSYFNKQRPLLTTAIRDSKDERLRIAIELGVQTRRAYQKNCKIVIIKLDGFNNRSFHLSILSNDSILLESLYLIKTDGLLADSETPVHLMNLQSLKKMLGVVVNEDYRFIKTTIREYVPEMGDFRFYHNYQKVASMCVFFHKTGVQLEGNIGHNILRHLPSEDHPHQNKYIYAKLYFPDLQMSKNTKKISFSNTTQIFNLNSTKLTVVNCKLFIILHPNSIQDKPKIELIRAILMFYNHLDMFFGNFTSPKIRLTLKGILLPDIGKQIFYEGDKHLDLQLTNWSNPDGDICNNLSALRVAAIVQGDLQTYHILHLNYLIKSFGGIDERNDSCPGIMHYNSKWVHPVPLVWSHCSIEKLSEYFNEKDCSWFKKNKPSLSTEIRDPKDDRFRLEIESDVRSRSLYELDEESQVGVAINVTNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2EB08</accession>
    <name>A0A8J2EB08_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Similar to EFTUD2: 116 kDa U5 small nuclear ribonucleoprotein component (Gallus gallus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HICCMSTLAB_LOCUS295</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001114">
        <property type="protein sequence ID" value="CAG5073351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2EB08"/>
    <dbReference type="OrthoDB" id="364892at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071007">
        <property type="term" value="C:U2-type catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030623">
        <property type="term" value="F:U5 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04098">
        <property type="entry name" value="eEF2_C_snRNP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04090">
        <property type="entry name" value="EF2_II_snRNP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01683">
        <property type="entry name" value="EF2_IV_snRNP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16264">
        <property type="entry name" value="snRNP_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04167">
        <property type="entry name" value="Snu114p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.240:FF:000004">
        <property type="entry name" value="116 kDa U5 small nuclear ribonucleoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000029">
        <property type="entry name" value="116 kDa U5 small nuclear ribonucleoprotein component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000009">
        <property type="entry name" value="116 kDa U5 small nuclear ribonucleoprotein component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1430.10:FF:000001">
        <property type="entry name" value="116 kDa U5 small nuclear ribonucleoprotein component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.870:FF:000002">
        <property type="entry name" value="Translation elongation factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000646">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.870">
        <property type="entry name" value="Elongation Factor G (Translational Gtpase), domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1430.10">
        <property type="entry name" value="Yeast translation eEF2 (G' domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031950">
        <property type="entry name" value="EFTUD2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044121">
        <property type="entry name" value="Snu114_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005517">
        <property type="entry name" value="Transl_elong_EFG/EF2_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035655">
        <property type="entry name" value="U5-116kDa_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42908:SF6">
        <property type="entry name" value="116 KDA U5 SMALL NUCLEAR RIBONUCLEOPROTEIN COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42908">
        <property type="entry name" value="TRANSLATION ELONGATION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03764">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16004">
        <property type="entry name" value="EFTUD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00838">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00889">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="EF-G C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0687">Ribonucleoprotein</keyword>
    <feature type="domain" description="Tr-type G" evidence="8">
        <location>
            <begin position="131"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="27"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAG5073351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="978" mass="110530" checksum="296B143C8A3C9392" modified="2022-05-25" version="1">MDADLYDEFGNYIGPDLASESEEENEYDHAGDETEDKDRSDEEMDEDKDEPRDVIDQSLQVVLHEDKRYYPSAMEVYGPDVETLVQEEDAQPLDKPLIAPTRRAKFQIKQQDLPDTTYNIEFLADMMDTPALIRNIVLLGHLHHGKTTLVDCLVRQTHPYMHNVTDEKPLRYTDTLFTEQQRGVSTKSTPVTLLLQDVKSKSYLMNIFDTPGHVNFSDEATAAIRLSDGAVLVVDAAEGVMLNTERLLKHAIQEKLALTVCINKIDRLVLELKLPPLDAYYKLRHIIEEVNSLIALYSDSENPSFVSPALGNVCFASSEYNVCFTLKSFVALYQRTHESLNVEEFAKRLWGDVYFNSKTRKFTKKPPHNTAQRSFIEFILEPLYKIFAQVVGDVDSTLPDVLDELGIRLTSEEMKMNIRPLLRLVCTRFLGDLSGIVDMCVTHVPSPQDHASTKIQHIYTGPIDTPLAQDMVNCNPDGRLMIHSTKMYPTEDCTLFHVLGRVMSGTLEAGQKVRVLGEAYSRADEEDSRVLSVGRLWISEARYQIELNRVPAGNWVLIEGIDRSIVKTSTITDLINSDDLHIFRPLKFNTQSVIKIAVEPVNPSELPKMLDGLRKVNKSYPLLGTRVEESGEHVVLGTGELYLDCAMHDLRRMYSEIDIKVADPVVSFAETVVETSSLKCFAETPNKRNKLTMIAEPLERGLAEDIEAEHVKITWNKKRLGEFFQTKYDWDLLAARSIWAFGPDATGPNILVDDTLPSEVDKTLLSSARDAIVQGFQWGTREGPLCEEPIRNVKFKILDAVIAQEPLHRGGGQIIPTARRVAYSAFLMATPRLMEPYLFVEVQAPADCVSAVYTVLAKRRGHVTQDAPVPGSPLYTIKAFIPAIDSFGFETDLRTHTQGQAFCLSVFHHWQIVPGDPLDKSITIRPLEPQPATHLAREFMLKTRRRKGLSEDVSINKFFDDPMLLELARQTEFLNYPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2EBY5</accession>
    <name>A0A8J2EBY5_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HICCMSTLAB_LOCUS2153</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IF-3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001117">
        <property type="protein sequence ID" value="CAG5076343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2EBY5"/>
    <dbReference type="OrthoDB" id="21573at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070124">
        <property type="term" value="P:mitochondrial translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032790">
        <property type="term" value="P:ribosome disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.10">
        <property type="entry name" value="Translation initiation factor 3 (IF-3), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036788">
        <property type="entry name" value="T_IF-3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001288">
        <property type="entry name" value="Translation_initiation_fac_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10938">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR IF-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10938:SF0">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR IF-3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55200">
        <property type="entry name" value="Translation initiation factor IF3, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG5076343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="254" mass="28842" checksum="EF64C017EA154A4C" modified="2022-05-25" version="1">MAINALCKSLRNYNFTRIISNNLNPIGYNNKISQPACILPRVMLLTDNDSVNINYNKCYCNIIGLEDPVNPKKKKVFVPRITLLSNKDEISIVTLEAAQKLANRHNMKLVKIIDFDTKTERPVYKLMTIQEYLQSEATTKAQAKEAKERTIKEDKTIAMSSKISEHDLFTKIKSMNKMLGKRHGVQVIIAVDGNKEKANTVRDTIIEHCKDTAKISSKTETASNLKVILRPILNKLNQQSEEEYTDKLADNKMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2EDC2</accession>
    <name>A0A8J2EDC2_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Similar to Nep1: Neprilysin-1 (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HICCMSTLAB_LOCUS1959</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase M13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001116">
        <property type="protein sequence ID" value="CAG5075978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2EDC2"/>
    <dbReference type="OrthoDB" id="6475849at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08662">
        <property type="entry name" value="M13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1380.10">
        <property type="entry name" value="Neutral endopeptidase , domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000718">
        <property type="entry name" value="Peptidase_M13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018497">
        <property type="entry name" value="Peptidase_M13_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042089">
        <property type="entry name" value="Peptidase_M13_dom_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008753">
        <property type="entry name" value="Peptidase_M13_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733:SF237">
        <property type="entry name" value="NEPRILYSIN-LIKE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733">
        <property type="entry name" value="ZINC METALLOPROTEASE FAMILY M13 NEPRILYSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01431">
        <property type="entry name" value="Peptidase_M13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05649">
        <property type="entry name" value="Peptidase_M13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51885">
        <property type="entry name" value="NEPRILYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M13 N-terminal" evidence="11">
        <location>
            <begin position="69"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M13 C-terminal" evidence="10">
        <location>
            <begin position="502"/>
            <end position="689"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF05649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAG5075978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="691" mass="79409" checksum="7A393C5B7780E93D" modified="2022-05-25" version="1">MTVRDKNILISVISKIGVICLILPIISARILGLTSPLGPINKCETDECKTERLETAALILKYRDDTTSPCDNIFQHVCGNYEKSDLTHNYDFIESTRTAFRDKMIGEEMEWVDKSTVYKLIHDFYTVCMDEIEAGGEKAWETLKSAINSLGGWPAVESDQWKEADFNWIDFISNAKKLGFKSPFLHWVPKTDDEMTVLTFSLQMPSSHFEEGIDPDIPLHRQIYTDLMFKMGFDLGATDKKIDKDLDDAVEFEYALYNLTRYDTAVPLNMMMEELQKEYPSVDWSKFVEKTLTPYLDAGDKPVLSVDSPGRMKKFFDLMEKTPKRVQATYGVWKVIQSAIPLLRGAYPKIREEFRELLNQAEIPREAYCDEMTTNYADLAVARYYLDHFESSKETIGNMFSMIKGKIIEMLKESKKLSEDEKKQGVEIMEKMDYTIGSSKKLSDVKELEKYYEDAKLVTDNLLQSVLNMNIFKRMRNYSNKWRAEQFAPQKLASAGMPENFENHLYIPISMIPNLMFDNNLPMYLNFGAAGSMMAQAMFSSVAHLGKTFAEDGKVIPDDQYKCFMQMTDNFTDPMIREALLENALDEMLGLYIGFQAAYKAYHQYVAESGPELALPEVPYTVPQLFWVAWTQVLCYAKGEEIPLPKPFEGSDLNVMEYANMMMMANVPQISEDFKCPVGSLMNPQKKCTWW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2EDF3</accession>
    <name>A0A8J2EDF3_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Similar to Adar: Double-stranded RNA-specific editase Adar (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HICCMSTLAB_LOCUS1485</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001116">
        <property type="protein sequence ID" value="CAG5075331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2EDF3"/>
    <dbReference type="OrthoDB" id="10268011at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003726">
        <property type="term" value="F:double-stranded RNA adenosine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008251">
        <property type="term" value="F:tRNA-specific adenosine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006382">
        <property type="term" value="P:adenosine to inosine editing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002466">
        <property type="entry name" value="A_deamin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014720">
        <property type="entry name" value="dsRBD_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10910:SF62">
        <property type="entry name" value="AT07585P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10910">
        <property type="entry name" value="EUKARYOTE SPECIFIC DSRNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02137">
        <property type="entry name" value="A_deamin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00035">
        <property type="entry name" value="dsrm"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00552">
        <property type="entry name" value="ADEAMc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00358">
        <property type="entry name" value="DSRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54768">
        <property type="entry name" value="dsRNA-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50141">
        <property type="entry name" value="A_DEAMIN_EDITASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50137">
        <property type="entry name" value="DS_RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="19"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="domain" description="DRBM" evidence="4">
        <location>
            <begin position="101"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="DRBM" evidence="4">
        <location>
            <begin position="248"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="A to I editase" evidence="5">
        <location>
            <begin position="361"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="58"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAG5075331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="678" mass="75328" checksum="A7D7FF0E5B19FE00" modified="2022-05-25" version="1" fragment="single">DCNPHCAPLSFSLTTKVSLLRYCDIFISFLIFKNIIFIQYFKMSNGVQVLNNNQSQIKKGSQSVRRQAKNMEQKNNSGTKRPGDPIIEGAPIPKKRHKNPQPKNAVCALNELKTGAVYKVVSQTGPTHAPIFTIAVQIDGQLYEGKGRTKKMAKHAAAELALRNIVQFRNTPEIHQAIGCQALTTVEPDFTSDVTEKDNHLVNAFKPLLQEPKNPSKFIDKGPVALINELYPGVIYNCVSDNGESYAKFTIAVTIDGETFEGTGPSKKLAKAAASKAALAKLRNVHSSTFCIPLPVRVLPNFSNFSSTHESMSLPQMLADKIGKMVNSKFTELMQNKPQHARRKVLAGIVQTKGNDAELICVTTGTKCISGEHLSVTGGALNDCHAEVVARRCLCEYLYQQLKLHTENRGEESILEEKNKKGFKLKQAPCGDARIFSPHEENESVDKHPNRRARGQLRTKIESGEGTIPVKSSEGIQTWDGVLMGQRLLTMSCSDKIARWNVLGVQGALLSHFIEPIYFHSIVLGSLLNPSHMYRAVCGRIENTIQGLPPPYRLNKPLMSLITSSEVRQPGKAPNYSVNWTTGQTEAEVINCTTGKDELGKPSRISKQGLFRMFFNLLGKISTIDDIDRDICHQYLDAKSTVQDYSHAKRQLKEAFVRAQLGNWVKKPIEQDMFEVDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2EG32</accession>
    <name>A0A8J2EG32_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS886</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001114">
        <property type="protein sequence ID" value="CAG5074114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2EG32"/>
    <dbReference type="OrthoDB" id="7684881at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035228652" evidence="1">
        <location>
            <begin position="25"/>
            <end position="546"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5074114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="546" mass="63503" checksum="7D75D5764800ED6F" modified="2022-05-25" version="1">MIFSHNLLLWIGSLLVAVAPVIKSETKGLIEYKNVRAGATVNRLQRNESTIEVLGSIFKSNSTYPEIYRNFTEFVRYPPHWHSRQFNCYESIYLVSHPSVKADNKFSSNNAIERSFLLLEEDLLKHEKFNIDDKFKNSSYTCVLYELCNLKEERIKKNVAVFGADDLPPNISTIIYVYEKDPIKEQSFSSYTDKRIAYKSPIVSATNNTKLEEWTEDFLNKTQSFLFNFENMPVKNQNEIYKHMESDAIRDFRLVNLPTLSDKLIKLPSTKQQLQELEPGCTLNIRELKGDTVSVITIMRFLLFEKIFSESDENFAMTIRTYNNDEKIKSSCPYQRLAFQSNDHINDHQNLEFFDCLVEHKQFGIPGYLTKEFKRMEVRVCRTVKKESAEEPLTIINWHKDFEDIGYNVFIRENIIIKYPKEGETHYVSSVYKGDCLYQSLPLFTSELISGSGNVEFINKVTELLLNTETPKRSLYQVLENETLKSEVKKQFGDNYLLSVNLRPMHTKRPLPQLNLIEYSFNFGNSLQASLLTIFVAMIAAKLLIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2EH18</accession>
    <name>A0A8J2EH18_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS1473</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001116">
        <property type="protein sequence ID" value="CAG5075319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2EH18"/>
    <dbReference type="OrthoDB" id="10660444at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="487"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="612"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="688"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="627"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="700"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="751"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5075319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="751" mass="83544" checksum="20509FCD5725ECB6" modified="2022-05-25" version="1" fragment="single">MILAQRGDKSFPIMLCLCSGRSQPLFSAIFGFLQQQGPTLCNNIDTIVSSLEKELISSIRESFPLKNVRYDWKNVVKSSSSYNDALKFSWALLLVPISLREEAFKKILEEAEKIEDAYKEMPNYLRYLQRLDRILKSSGPIRVINITGTFAQDLIEQCGTGDLSIFTLLSTMKSALQNGSLLLKSTQSSTPVIDHFSNQHIIETGQITIETFLIEVIEPYMNELISQIKSSQKSDIKSPVFKEIEDPKRVKDERNRYRTSNEIQPVNVNRIDSFRKTTSATTKGIGTFGMTQQQSLPAFQARKTVLRQSNKDLTPSVDYLGPRSTFTRLRLNNPCATATYVPSSLKHSTPQKKPVGANPTLGFSLESAGTDYCRDQECDREFERTRRSLGTIGEDEFPDYRHELKFKSRFPQLRNNEDPTWNVNTTSTGMKSFGTFGKTQQQSSPAFQARKTVLRQSNDYLTPSVDYSGLRSTSTRRRLNMSCATATYVPSSSRDSTPHKKSVSVNPTLGFSLESASTDFRLDQESDRESRRTLTRYTDAEYLEDSLIIGSLDTDAGANIDVVDIHESPSSDNDDVAHSIPRLLTTPNSEVLPSPIEFSTVNVVAEVIENPLHNESTGRGDGGLSTAPVNSRSLPISSPEVQPPAEEFSTSNVVAEVIEDPLLNESAGRGEEESPSGNAAPDILEDTLRLGSDDSDNEDNPGNSGTATARPSENDIIVIDSYSEQDDDENQRCCCCRVNRAYLVAYKALSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2EH92</accession>
    <name>A0A8J2EH92_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="11">CYP4G111</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HICCMSTLAB_LOCUS1627</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001116">
        <property type="protein sequence ID" value="CAG5075473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2EH92"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20628">
        <property type="entry name" value="CYP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050196">
        <property type="entry name" value="Cytochrome_P450_Monoox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24291:SF106">
        <property type="entry name" value="CYTOCHROME P450 4G1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24291">
        <property type="entry name" value="CYTOCHROME P450 FAMILY 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8 9" id="KW-0349">Heme</keyword>
    <keyword evidence="6 8 9" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="499"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAG5075473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="559" mass="63423" checksum="82AE03B78119B9D4" modified="2022-05-25" version="1">MSVAGPEIIPGTVAATTATAGMSAFSVFLALLVPALVLWYVYFRVSQRHVLELAEKIPGPPGYPLIGNALEFMGSSDSIFRNIMERSNEFDQVVRLWIGPKLLIFLVDPRDVEVILSSHVYIDKSAEYRFFQPWLGNGLLISTGQKWRVHRKLIAPTFHLNVLKSFIDLFNANSRAVVEKMRKEGSKEFDCHDYMSETTVEILLETAMGVSKSTQDRSGYEYAMAVMKMCDILHLRHTRVWLRPDWLFNLTKYGKDQIQLLDVIHSLTKKVIQRKKEDFKAGKRNFIKTTESKDAKLTSVEGLSFGQSAGLKDDLDVDDNDVGEKKRLAFLDLLMEAGQNGTVLTEQEVKEQVDTIMFEGHDTTAAGSSFFLSMMGCHPDIQEKVIQELDQIFGDSDRPCTFQDTLEMKYLERCLMETLRLYPPVPVIARQIKTDLKLASGDYTVPGGCTVVVGTFKMHRLPHLYPDPDTFNPDNFLPEKTANRHYYAFIPFSAGPRSCVGRKYAMLKLKILLSTILRNFRVKSDIKESDFRLQADIILKRAEGFRVRLESRTQVGVTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2ENQ6</accession>
    <name>A0A8J2ENQ6_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Peptidase S1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS1845</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase S1 family. CLIP subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001116">
        <property type="protein sequence ID" value="CAG5075755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2ENQ6"/>
    <dbReference type="OrthoDB" id="10674982at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051487">
        <property type="entry name" value="Ser/Thr_Proteases_Immune/Dev"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24256">
        <property type="entry name" value="TRYPTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00024195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5075755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="659" mass="75199" checksum="AAE50F09AFF48FF3" modified="2022-05-25" version="1">MVSISGFLHQEYRVSLTPGSSGLYEEEAVKLYDEADCIIEDCGVIGDKERIIKNISFVGSPIVCKLSDQDQYVQVGLTSFVARWSIVQRIEHIGSSITNAMDTWLAWKMLISSIILIGGTESCATVYNGTMNQVTESNTKSPWLVLIINREKNSGIQGLSYGSLIKEDVVFTAASKIARLSSSQLEVVINWQITDETIYDSRLVSLIGTPLNFDKNQVKPSDWAILILHQPFELYGKVGIIPLADKSHQWDSEDCYIYRWIYVEADYKIESRYIEAEGFLHREYRVSLTSNSSRLDEEKMVELFYELDSIMLNGHRTFEGERFIKKISFVGSPIVCKLLDQDQYVQVGLTTFVAQWSVYATEYDLDIEDISEYDEDTFVDLIKDFDERIEHIGSSITNAMDISLIWKLLVSSIILIGGSESCFTIFNRTITEVTEACKHQIAMVGAYHQPSRQEICWDARCDSRSILSLFSPPNLDKNHQVTPSDWVLLKLSKPFELYDKVGIITLADRNHQWDSEDCSIYHWMSVRSEYKVGEEHILEEGYLHQEYRVSITPGSFGLYEEEVVKLHNDVDCIVDKCSLSYGGLRDVRNISFVGSPIICKLLDQDQYVQVGFTNFVGRLILDKTVDDLAFKDISEYNPDTFVDLTKDFDEVIRPKVLTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2GZ64</accession>
    <name>A0A8J2GZ64_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS86</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030000573">
        <property type="protein sequence ID" value="CAG5071783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2GZ64"/>
    <dbReference type="OrthoDB" id="7700450at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5071783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="128" mass="14540" checksum="7335D9356C797839" modified="2022-05-25" version="1">MSVPTKPMLALVQWIGGDYDKTYTPGVPVDWIFDFDLLTFDPTNEDESYVIEWRESKKNNKLTQSWKYFDARVVKTSPGNIGRACFTLTPRTYDEPKGGGNSRTGGIKVEHRRRGPASERGARKPRGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H0J0</accession>
    <name>A0A8J2H0J0_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Similar to PNN: Pinin (Pongo abelii)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HICCMSTLAB_LOCUS2189</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the pinin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001117">
        <property type="protein sequence ID" value="CAG5076444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H0J0"/>
    <dbReference type="OrthoDB" id="330772at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039853">
        <property type="entry name" value="Pinin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006786">
        <property type="entry name" value="Pinin_SDK_MemA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12707:SF0">
        <property type="entry name" value="PININ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12707">
        <property type="entry name" value="PINN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04696">
        <property type="entry name" value="Pinin_SDK_memA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Pinin/SDK/MemA protein" evidence="9">
        <location>
            <begin position="159"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="37"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="258"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="60"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="88"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="288"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="318"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="337"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAG5076444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="348" mass="39999" checksum="06E5C044C2CB8CD7" modified="2022-05-25" version="1">MRHLDSLDNAGADKLEAELQAARDGLRELDRDIRKILGRDLPDTENGMNQQSVRIGQKRLLQDDRKRNIPDYMGNNDHHSQGNKRSRWQSQSLSSPPTATPGEPKTVFSRLSARVPSTADDSDNDDDNPMKPAVSSRVIATPREVPSRQEVIRRERVDERSRQRNKRMFGALLGTLQKFRQEETKLKAKEDKKAEVEARVEEAKRREKEELKRERQQLFLSRKRQLAEVKALESKLARTEVERREKALAEEIEAIESQINANKQNDNLDKSESMEINEMQIMEDGEENRDPNPEVKEKVSEDTSPVAVKMEFQDAAVDDVKSTDHSDVSKVKKTEESNEEENLNENYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H1J5</accession>
    <name>A0A8J2H1J5_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS648</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001114">
        <property type="protein sequence ID" value="CAG5073875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H1J5"/>
    <dbReference type="OrthoDB" id="7699186at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="229"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="229"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="256"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5073875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="286" mass="31777" checksum="688B740CA521129C" modified="2022-05-25" version="1">MGKSKKRSRERDDNDIIEKRICRLERVLGDFIKSTQEHFEKAGGGQITSTSKENIPPNNQEKTDTAESAKESEKVTNTETDSPEEAVETEAQSDPTLTSSAETDLSKEKVLDEDVETVLGADPTAGNKKDLDLHPSLVARWPTWLSEGLPKESKESVLDKYSRKGNINLEAPELNEEVLVTLNESGVKRDKLFTAEQNLVGSAMSAVGDSISLILKDNEEPVDRLPVTSRSLNWKSPHPNQGNSYVGPRTSHQKFSKSNPQSSRSAYSNTSNQTKTNRTTYQDRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H261</accession>
    <name>A0A8J2H261_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Lipase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HICCMSTLAB_LOCUS1087</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the AB hydrolase superfamily. Lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001116">
        <property type="protein sequence ID" value="CAG5074854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H261"/>
    <dbReference type="OrthoDB" id="9974421at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000057">
        <property type="entry name" value="Lipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025483">
        <property type="entry name" value="Lipase_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11005">
        <property type="entry name" value="LYSOSOMAL ACID LIPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000862">
        <property type="entry name" value="Steryl_ester_lip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 7" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="9">
        <location>
            <begin position="76"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="8">
        <location>
            <position position="169"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="8">
        <location>
            <position position="348"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="8">
        <location>
            <position position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR000862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000862-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAG5074854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="434" mass="50155" checksum="D09FE7B632A136DA" modified="2022-05-25" version="1">MGLLIYKMIGSVLGVSEKKPKIRIKNLDSRLESFIDLVEESGYLGEEHRVKTEDGYDLTVHRIPGGPQSPVRFGKPVILLLHGLMSASDIWILRGPGQDLAYLLSDAGYDVWAINVRGNYYSTLHNSITNNSAYWDYSWHENGMYDVPATINYILSKTRKSELSLLGYSMGGTEILVLLSSRPEFNHKINIAITWAPAALVSHDIPGFFPNFLFRHSKQIKDLFSEYNLYQVMPRVSKQWSDFLNVWFSLCWRLNIKSICLKLLDVTLGFKNLNDLDLALILRIKDHYPQGTSLKTILHYGQVFKNRRFQQYDYGKMINLIKYNDMIPPEYPLNKITTPLIIYYARNDKLVTKNDVEMMLKKIPTAIAKEVPDDKFGHLDFIISKNIKHLVYDRIDAIDLVRYRPPYYIAIAISQKIGKMLTFRGKYRGLDMSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H731</accession>
    <name>A0A8J2H731_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS3088</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5080726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H731"/>
    <dbReference type="OrthoDB" id="8174021at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060857">
        <property type="term" value="P:establishment of glial blood-brain barrier"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035159">
        <property type="term" value="P:regulation of tube length, open tracheal system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019991">
        <property type="term" value="P:septate junction assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36694:SF4">
        <property type="entry name" value="LD42595P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36694">
        <property type="entry name" value="PASIFLORA 1, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="58"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="113"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="148"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="174"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="232"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5080726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="253" mass="28931" checksum="5227F5C11FD28CE7" modified="2022-05-25" version="1">MNYGKKSPSMGTPSIYSHVTTRSSANLRSSRSVKSVKIPWYQRPILTRPYILDIQRTAMLTAVFSLLLAIFTIATSIFDVYCLHEAAPGTKHYGYYIISYEFVYVGNPHIRNALIVAALFSLLGSIILLVTSAILINALRKEYEKRMVYWLYCFAAFTVFRMFAYLFFCIVNDMIFTYNIMICLLWLLFLCYSVYGWLTVYTLYIELSDLTRLEDFAHLRIGTMQSLNASTTHSIAGSRPTTPHSTVSTMPVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H7B0</accession>
    <name>A0A8J2H7B0_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS3208</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5081164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H7B0"/>
    <dbReference type="OrthoDB" id="2152335at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="159"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="170"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="180"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5081164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="206" mass="23723" checksum="21020C8A671559F7" modified="2022-05-25" version="1">MFQTLRRLMPLQSLKLLSVVIVCNCILFEIPFRETSGKVVKEVTEVTTLRVSHDTKFGVASYKLTSNILTENKEHRNAVGILDASHQYTNGCYNGVYHDDKDTSAQHSREEISISESEVPSKLENGHACRHSKIVKESTSEYKLKLPPDELKNVRFLDTKGNNDSGIEMPLKHNERLETSEEEEEEEEEEEDNDNSEYFEKLKMKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H7H2</accession>
    <name>A0A8J2H7H2_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Similar to egr1: Early growth response protein 1 (Danio rerio)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HICCMSTLAB_LOCUS3202</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5081142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H7H2"/>
    <dbReference type="OrthoDB" id="10018191at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990837">
        <property type="term" value="F:sequence-specific double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000404">
        <property type="entry name" value="POZ-, AT hook-, and zinc finger-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000303">
        <property type="entry name" value="Zinc finger protein 41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000395">
        <property type="entry name" value="zinc finger protein 513"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24408:SF64">
        <property type="entry name" value="LINKING IMMUNITY AND METABOLISM-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24408">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="425"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="461"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="489"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="517"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="50"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="115"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="327"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="55"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="117"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="136"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="200"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="334"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAG5081142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="573" mass="62776" checksum="84E0209CDD92EE60" modified="2022-05-25" version="1">MNTEKKCACYSIRYQTHLGGSTVVAEGVIGGIGGPGGGCRASSMTMAESVVEDTPPGPAKPPPACTNNNTLSATANRNHRFRKRKCLTQVLDALQAHKGSIEESENNNQPLHLESTSLEDQDPDHDQDHDQDDIFSSPRSSSRASRASTENNLSLTDKRLKVEPLESPLHTPSDEESSPSPAIGGGLHLQRHLPNLPNHPNHHNHHNNHNHHNHHHNHQQYSFRAPHLTSANYRGCACLSCTSPNIILPSPTSPQAPLTPLTPVSSTPTNITPLTPVTPSSYTFEHYLHTKYLPIDATSERKDVEVPGGWIDQKPLLLWPTSRQNGALESDAKSNQSNNPNPNSFQEFPLDLSMKNCNSATTEIVGRPGGLQLLPSSVGSRGALTFPVIRGDVASPTTKESVAFRFNIEVSPVVEEMPPGTDLAYVCPACGQMFSLHDRLAKHMASRHKRQGAKDATAKAYSCDVCNRSFARSDMLTRHMRLHTGVKPYTCRVCGQVFSRSDHLSTHQRTHTGEKPYKCPQCVYAACRRDMITRHLRTHARYVDGQNNKCEAGQENDSSGFTAINALAGVKTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H861</accession>
    <name>A0A8J2H861_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Similar to MMADHC: Cobalamin trafficking protein CblD (Gallus gallus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS3694</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5082959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H861"/>
    <dbReference type="OrthoDB" id="10263782at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009235">
        <property type="term" value="P:cobalamin metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019362">
        <property type="entry name" value="MMADHC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13192:SF3">
        <property type="entry name" value="COBALAMIN TRAFFICKING PROTEIN CBLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13192">
        <property type="entry name" value="MY011 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10229">
        <property type="entry name" value="MMADHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5082959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="343" mass="39683" checksum="67D6DCA72E8D120B" modified="2022-05-25" version="1">MNAICSLFGEHRRSRMFFVPAHSLRSVFWCSLIEKQPLATICKFSRGVLKTLILNQHAKSYFEMYCGKIIQKNYSKSINLIFAAKYSRRSAKNTTTYKLIKSNGIDADIDNGELDNNPNWELFGPRGFRFYLPGSIGPGWLDQSTTAQVETRSILIPRNKEECDDGDDFNSLEINDMINVGKTKNNKLKRVRRKSHQNQPILHCIAQECPMLLRKGIQELFPSCIEVASPHLTIVTITQKLSPRMMRWSKEIETEKLAKFFLLAASDICTKLKMFGYWADFINPFSGQPYLNPHKTGVLYKTDERFRCLGFKVHRNNNCKIIMHENKGSEFIGKFFCFFKLFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H872</accession>
    <name>A0A8J2H872_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="12">ATP-binding cassette transporter subfamily C member 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HICCMSTLAB_LOCUS3966</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5083914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18579">
        <property type="entry name" value="ABC_6TM_ABCC_D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03250">
        <property type="entry name" value="ABCC_MRP_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03244">
        <property type="entry name" value="ABCC_MRP_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000997">
        <property type="entry name" value="Multidrug resistance-associated protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000026">
        <property type="entry name" value="Multidrug resistance-associated protein lethal(2)03659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000014">
        <property type="entry name" value="Multidrug resistance-associated protein member 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000163">
        <property type="entry name" value="Multidrug resistance-associated protein member 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044746">
        <property type="entry name" value="ABCC_6TM_D1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF415">
        <property type="entry name" value="FI20190P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="106"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="148"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="224"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="248"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="332"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="368"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="771"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="850"/>
            <end position="873"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="927"/>
            <end position="945"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="951"/>
            <end position="970"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1027"/>
            <end position="1060"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="11">
        <location>
            <begin position="108"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="440"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="11">
        <location>
            <begin position="778"/>
            <end position="1100"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="1132"/>
            <end position="1361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="686"/>
            <end position="706"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAG5083914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="1411" mass="158836" checksum="43121C471D6A5FB1" modified="2022-05-25" version="1">MTRKVEMKLEKNPVENANPISRLFFWWTVKLFKKGNRDGLTMEDMYAPLAHDESKGLTNELEKAWNDELKKSMRKKPNNIHDGNQIKPPEPSLIKAIFRTFWLKNLYIGLLLLFQTVILRSVQPIFQAQVISFFDSGDKNSTTRNETLGYATALIATTLGVTFIMHHTNVDSQQIGMRIRIACSSLIYRKSLRLSKTALDTTAGGQIINLLSNDVNRFDLLPMYFNYLWIMPIQIIVVGYIMWQSIGIYTLIGFGSLLLLTIPIQAYASILSGKLRASIAGLTDRRVQLMSELVAGIQVIKMYAWEKPFNKIVSQTRLAEIKKIHSSSNVRGLYTSLMVFTERTTLYVTLIAFVLMGNPMKADITFQLSSYFNILQMVVAICFPQALILFSEAIISIKRIEEFLLLDEISKSQDSNKLIKPASLTDSTKSSAKIGSAVRIELDKVSANWIVGQLPPTLCDVTLNVKPGELCTLVGPVGSGKSSLLNLLLQELPVSAGTVGLFQFENKKSIVFKSKHRFIQDNPEMTISYASQDPWLFSGTIRENILFGLEYDHTRYLEVTRVCSLMKDFQQFPNGDLTSVGERGASLSGGQKARVNLARAIYKQADLYLLDDPLSAVDARVARLLFNECISKYLHGKTRILVTHQLNYLKQADTIAMIDRGCIKHQGTFESLTKTNPEFNNLLNNMKSNDTESLGDANENHSPKKLSEEVNFSARFDKSRTSRISIRSQDSYQFLPYQEFTTAECNTQVDSETMESGRMSNKVYYRYFREGGNIIVLIIMIIIYILSQIATSGADYWLSYWINIETIRNKCENSAKNNCSVSEFEYKSMVNNTFFQSLSLLDSDGFLSTIYAVHIYTACIVGCIVLVTLRSFFFMHVCMNAGRKLHNHMFSNVLQATMNFFHMNPSGRILNRFSKDVGAMDELLPRAMLEAIQIFLVMAGILVIITSVNPWMGIPIVIMGTIFYLIRIYYLNTAQDIKRLEGIAKSPVFSHVSTTLDGLMTIRSRGKDVERMLCNEFDHYQDIHTGAWYLTIATGSAFGLILDLISCVFVTCVCYSLILMDPENTFGGSVGLAISQSLILTGMLQYGVKQTAEVQSQMTSVERIIQYTDLPKEGPMESTNPPPSDWPSKGDVKWQNVSMSYKAEDPPVLKNIELDIESGWKVGVVGRTGAGKSSLISALFRLADDGLQGKIIIDDLDTKTIGLQDLRAHISIIPQEPILFSETLRYNLDPFGKYSDNDIWEALREVELNDLTLDQWVTESGSNFSVGQRQLICLARALLRNNKILVLDEATANIDSQTDAMIQRAIRTKFANCTVITIAHRLNTIIDSDRVLVMDNGNAAEFGSPYELLIENSNSMFAEMVDQTGSIMAEKLREEAIKYHNERESFGTFDDDENQQMCDIDSSAIIDSIKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H881</accession>
    <name>A0A8J2H881_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Dynein axonemal assembly factor 1 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HICCMSTLAB_LOCUS3887</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Cilium-specific protein required for cilia structures.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5083617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H881"/>
    <dbReference type="OrthoDB" id="1939344at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050576">
        <property type="entry name" value="Cilia_flagella_integrity"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025875">
        <property type="entry name" value="Leu-rich_rpt_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45973:SF8">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN 49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45973">
        <property type="entry name" value="PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT SDS22-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12799">
        <property type="entry name" value="LRR_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="101"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="454"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="569"/>
            <end position="592"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAG5083617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="773" mass="86211" checksum="13D542199066E859" modified="2022-05-25" version="1">MPISNNKSQGKKLSFNLCGKSATVTSSTINGEEGDQDDTKFFTIAPALPVLPGAPAPSKLTTKRSYGTLTPTSSTYGFDDAEVGGCDVVALQQQQSTSDSGYKTTTVVASRTPAERDKNPDRICLDRRGLTSFPDIVGEPKLRLMSLQHNLLSRIEGQNFSQLTKLVFLDLYDNQIEKIYDLAPLENLRVLLIGKNRVKKIEGLRSLIKLEVLDLHGNQIVQITGLENLSSLKVLNLAGNNVKVIGFNDFHGLLALKELNLKRNKIKKLLGFSETPQLQKLIEDMGSLAKALEIREITIDGNPVTLNADCISFLVSYLPNLQALSTMQINEQVRRAAMAWRLTKEQSNSAFLDLSTQVCVNVRREEVIINAKKNWDLLRSQTKCLTSSANKHSNIKNERVRGLNLQNSTKFDAVKIKAEEASNLGHAQKPSFGSLSSINYDKIDAKKIQFKRRSNSTDTLNGGKGSNETETTDSELESSESHESLKSALRNHLIKTNLNLGSQKSEESKNIYSFGDEEIKKKERRNEFSLQLATDSRSFYNLVQGSTRRQLSYRQINLAGIKKANSLDSREEFSSQSSTASKELDSDDEKGRVRSAQVKKIVSYKSNRAATARVKHRAVATPVVPVQFNAPKEKEQGGDYLVEIVGRCLNVYGQGALRYIDRSWDSVKANDVNTVKFNYVQFNGVATVLNKLKMRFSNAQHFIFKETNISHLGQLNALAEVQGLTSIQIEAEGNPIISKNWRVYAVFRLSHWGLRIINGKEDDLILRHKVIIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H8A9</accession>
    <name>A0A8J2H8A9_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 6">Adenylyl-sulfate kinase</fullName>
            <ecNumber evidence="1 6">2.7.1.25</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HICCMSTLAB_LOCUS4060</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the synthesis of activated sulfate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>adenosine 5'-phosphosulfate + ATP = 3'-phosphoadenylyl sulfate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24152"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58243"/>
            <dbReference type="ChEBI" id="CHEBI:58339"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.25"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="6">Sulfur metabolism; hydrogen sulfide biosynthesis; sulfite from sulfate: step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the APS kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.25" evidence="1 6"/>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5084259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H8A9"/>
    <dbReference type="OrthoDB" id="7666427at2759"/>
    <dbReference type="UniPathway" id="UPA00140">
        <property type="reaction ID" value="UER00205"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004020">
        <property type="term" value="F:adenylylsulfate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050428">
        <property type="term" value="P:3'-phosphoadenosine 5'-phosphosulfate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070814">
        <property type="term" value="P:hydrogen sulfide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000103">
        <property type="term" value="P:sulfate assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02027">
        <property type="entry name" value="APSK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00065">
        <property type="entry name" value="Adenylyl_sulf_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002891">
        <property type="entry name" value="APS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059117">
        <property type="entry name" value="APS_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00455">
        <property type="entry name" value="apsK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003013">
        <property type="entry name" value="PRK03846.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11055">
        <property type="entry name" value="BIFUNCTIONAL 3'-PHOSPHOADENOSINE 5'-PHOSPHOSULFATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11055:SF1">
        <property type="entry name" value="PAPS SYNTHETASE, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01583">
        <property type="entry name" value="APS_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 6" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="APS kinase" evidence="7">
        <location>
            <begin position="39"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG5084259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="237" mass="26739" checksum="7602E31DEBF57AB5" modified="2022-05-25" version="1">MGIFLQEDNQINTNNITIQKNDVSREMRGNIIGKFKGFRGCTLWLTGLSGAGKTSIAFNLENYLVKLGIPAYSLDGDNMRSGLNKNLTFSKEDRQENIRRSAEVAKLFSDSGHITICSFVSPFSEDRSLARKIHQDVGLKFFEIFINASLDVCESRDVKGLYEKARNGTIKSFTGIGQNYQVPIDPDLILDTEQQTLDESTITLVKFLEGKKIIPNTPECRVEIRNNLFFNNQQTKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H8H0</accession>
    <name>A0A8J2H8H0_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Odorant receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HICCMSTLAB_LOCUS4200</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Cell membrane</location>
            <topology evidence="1 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the insect chemoreceptor superfamily. Heteromeric odorant receptor channel (TC 1.A.69) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5084792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H8H0"/>
    <dbReference type="OrthoDB" id="6597368at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005549">
        <property type="term" value="F:odorant binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004984">
        <property type="term" value="F:olfactory receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004117">
        <property type="entry name" value="7tm6_olfct_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21137">
        <property type="entry name" value="ODORANT RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21137:SF35">
        <property type="entry name" value="ODORANT RECEPTOR 19A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02949">
        <property type="entry name" value="7tm_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 10" id="KW-0552">Olfaction</keyword>
    <keyword evidence="8 10 11" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="9 10" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="28"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="125"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="165"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="190"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="261"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="293"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU351113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAG5084792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="382" mass="44199" checksum="C1C3B5DAEF76AE68" modified="2022-05-25" version="1">MEILTTNFFVLTLVGLWKPRGWTGVKSVLYHFYTTIVIFANISFLFSGIMDLEFVNVDITAIIDNISLLLSLVTIRQKTACAIGNRKNIKEIIDTLGRSPFKPQNQEEENIVKRFNGFTGYILKYYPVLFTMAITWYSIGHIFLMDPPQVLPYRGWFPYSYNSTGIYWITAIYQLYAICSAASINLAFDPLLPCIICHMCAQVHILRYRFDMMIKKLEVIYDTHPKDVIASSERRMVGEWVDHHISVLNLIKYINATWSKVIFVQYTASSLILCTVAYVLSHMNAASMNFAGNFFYFIAMNFQIFFQCFCANQVTLEFLDMTTALYDTNWFNLSNSLRRSLTIILCETFRPVLFTSSFFIILSLESFTKVIKCAYTVYNVLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H941</accession>
    <name>A0A8J2H941_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Similar to plc: 1-phosphatidylinositol phosphodiesterase (Staphylococcus aureus (Strain Newman))</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS3766</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5083209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H941"/>
    <dbReference type="OrthoDB" id="7697653at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5083209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="210" mass="24062" checksum="4EF5ED59FFB534BC" modified="2022-05-25" version="1">MKFCFINPLESEDLETSSQPERLRPPAVPGFIPSVLCGHKFFKEYKKSGNFISELPDDRRIGELSIVGTRESISYLLIDDIENRKRQEINIKNQLDSGVHFLDITLYVDSGIIMVSIGDIYIDKAFGEFIFDVNLFLSYHRLELVMIKLKQMFSNSKPYVSDLINKFRENNNGGSRLVTNWGLNDTLGMHRGKILLASEDNLLNNCLHIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H9D7</accession>
    <name>A0A8J2H9D7_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DDRGK domain-containing protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HICCMSTLAB_LOCUS4531</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Substrate adapter for ufmylation, the covalent attachment of the ubiquitin-like modifier UFM1 to substrate proteins. Required for ufmylation of Atg9; protects the nervous system during aging, possibly by stabilizing Atg9 and supporting its function.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Interacts with Atg9; the interaction is transient.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DDRGK1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5087509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H9D7"/>
    <dbReference type="OrthoDB" id="2285710at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044389">
        <property type="term" value="F:ubiquitin-like protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000143">
        <property type="entry name" value="DDRGK domain-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019153">
        <property type="entry name" value="DDRGK_dom-contain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050899">
        <property type="entry name" value="DDRGK_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48176">
        <property type="entry name" value="DDRGK DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48176:SF1">
        <property type="entry name" value="DDRGK DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09756">
        <property type="entry name" value="DDRGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01128">
        <property type="entry name" value="DDRGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="27"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="60"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="98"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049608"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAG5087509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="286" mass="32821" checksum="CDAB31084ED3E398" modified="2022-05-25" version="1">MDTTILISIAVGIVTLIIFLTIWSTRSKGKSVKEDENPRPRGQPVRRAAGVRNPRRMQHRREEPEPREAAGDGGSEDEGDEKAAELPDGKIGAKKRAKLEAKAEKKQAREAMEREREERKKREHMQQEEADKQRERERAEELKQEELEKKAREEKEKAEYEEYLKMKEAFSVEEEGFDQNDVDEENLLDEFIKYIQYNKVVVLEDLAGHFNLKTASVIERIQSLQASGRLTGVVDDRGKFIYISQKELEAVAKFVKQRGRVSIAELAENSNRLISLTPGNQTVEAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H9F3</accession>
    <name>A0A8J2H9F3_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Similar to Myrosinase 1 (Brevicoryne brassicae)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HICCMSTLAB_LOCUS3979</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glycosyl hydrolase 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5083965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H9F3"/>
    <dbReference type="OrthoDB" id="65569at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001360">
        <property type="entry name" value="Glyco_hydro_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10353">
        <property type="entry name" value="GLYCOSYL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10353:SF36">
        <property type="entry name" value="LP05116P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00232">
        <property type="entry name" value="Glyco_hydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00131">
        <property type="entry name" value="GLHYDRLASE1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAG5083965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="318" mass="37296" checksum="E27E68DDCC3D4515" modified="2022-05-25" version="1">MCLRVEKTLSFDFWKKIKLFHFFMFISLPNLSSCNDNKFPDNFVLGVGTSAFQSEGAWNVSNKGESIWDVLIHEKPDVVWGKANADVAANSYYLYKTDIDLVEKIGANAFKISISWPRILPNGFNNEINYDGIQHYHDVIDEILSRNITPYINMYHWDLPIRLQKLGGLANPLFVNWYLDYAEILFRTFGDKCHPWGLSAIIRRITTKYNTPAIVIGENGYRDEGQLDDIDRGQFFYYHLKEVLKLVREGFNIQGYFTWTLFDIFEWTQGYEHRYGLFSVNFTDPERPRVPKLWSAKVITDIYRTRLIPPSFESFSQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H9M4</accession>
    <name>A0A8J2H9M4_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Tube_Tollpathway_Cc</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS5077</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5089033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H9M4"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd08308">
        <property type="entry name" value="Death_Tube"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.533.10">
        <property type="entry name" value="Death Domain, Fas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011029">
        <property type="entry name" value="DEATH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029397">
        <property type="entry name" value="Tube_Death"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14786">
        <property type="entry name" value="Death_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47986">
        <property type="entry name" value="DEATH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tube Death" evidence="2">
        <location>
            <begin position="58"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="250"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="250"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5089033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="322" mass="36420" checksum="A0BCC4182A1B217A" modified="2022-05-25" version="1">MVNAETEIRKLRPKELCALAATLSPDSWKVLMGMIPKDGTQNVPMFTKEHLDIIESTGLKQRRLPAEIFLDEWSTMGRKRPTIGKLINLLIQIELFRAADYLAIGVLNEEPPKRPQNGPAAPIDFFVNFEGTPEMIHITDEVNEYQDVQKENYAAPSINNDNLQLAYEEEKFHAENVSKFPFNSKSDLMKFSSSSFEEKNNCDIKYGEEQEENVLPNFKELNMHNNNQQQSNVSNKGIIKSEKSSDSIISESSDLSTCESSYPSSSSSQSAVNPHNSIFLSDNLPVILKEMNGQDTNCESIQYSYSKESHQNLPLPILEYRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H9Q0</accession>
    <name>A0A8J2H9Q0_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="18">Similar to trr: Histone-lysine N-methyltransferase trr (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">HICCMSTLAB_LOCUS4756</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5088198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="308383at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098687">
        <property type="term" value="C:chromosomal region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044666">
        <property type="term" value="C:MLL3/4 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005700">
        <property type="term" value="C:polytene chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042800">
        <property type="term" value="F:histone H3K4 methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15666">
        <property type="entry name" value="ePHD2_KMT2C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.360:FF:000001">
        <property type="entry name" value="Histone-lysine N-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000002">
        <property type="entry name" value="Histone-lysine N-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034732">
        <property type="entry name" value="EPHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003889">
        <property type="entry name" value="FYrich_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003888">
        <property type="entry name" value="FYrich_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003616">
        <property type="entry name" value="Post-SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45888">
        <property type="entry name" value="HL01030P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45888:SF6">
        <property type="entry name" value="HL01030P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05965">
        <property type="entry name" value="FYRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05964">
        <property type="entry name" value="FYRN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13832">
        <property type="entry name" value="zf-HC5HC2H_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00542">
        <property type="entry name" value="FYRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00541">
        <property type="entry name" value="FYRN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00508">
        <property type="entry name" value="PostSET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51805">
        <property type="entry name" value="EPHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51543">
        <property type="entry name" value="FYRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51542">
        <property type="entry name" value="FYRN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50868">
        <property type="entry name" value="POST_SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="12" id="KW-0804">Transcription</keyword>
    <keyword evidence="11" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="17">
        <location>
            <begin position="3200"/>
            <end position="3308"/>
        </location>
    </feature>
    <feature type="domain" description="Post-SET" evidence="16">
        <location>
            <begin position="3612"/>
            <end position="3628"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="162"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="352"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="517"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="685"/>
            <end position="881"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="956"/>
            <end position="1012"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1135"/>
            <end position="1154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1192"/>
            <end position="1255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1477"/>
            <end position="1522"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1680"/>
            <end position="1711"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="2171"/>
            <end position="2208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="2262"/>
            <end position="2299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="2334"/>
            <end position="2364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="2399"/>
            <end position="2421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="2643"/>
            <end position="2672"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="2431"/>
            <end position="2558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="166"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="15">
        <location>
            <begin position="361"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="521"/>
            <end position="566"/>
        </location>
    </feature>
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        <location>
            <begin position="568"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="588"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="15">
        <location>
            <begin position="689"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="701"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="751"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="15">
        <location>
            <begin position="767"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="818"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="833"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="971"/>
            <end position="994"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="1205"/>
            <end position="1222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="1223"/>
            <end position="1233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="1236"/>
            <end position="1245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="1485"/>
            <end position="1506"/>
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    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="1692"/>
            <end position="1710"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="2171"/>
            <end position="2181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="2264"/>
            <end position="2290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="15">
        <location>
            <begin position="2643"/>
            <end position="2653"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="18">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="CAG5088198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="3628" mass="399748" checksum="A78EA0EF0A894BE7" modified="2022-05-25" version="1" fragment="single">IDPNHVHNQQNMVQRVIRTGQDMSASVRMMNAQTIPRPGLMQTTVNDNTGTSSEASEIPDNVTAELEKLEQEGAPMVEVEGVGAILGDLADDDDELLAEMGADFNILEYADPELGNITGGEKTNILDMDLEQVEVETKEEKQKKEKEEEQKSEVLAVNATAHSDIANESSNSGVSTPVEPTMVPNVAPAATAATMPISAASQPQGSIIQQQQQQSGTIIAPNHAQAMAVQQQMHQQVQQAAAMGRPMPPGTRLLSAEGVIGVVTSSNTVTISYPSTFPGHPQRILQSHMQHGAVPRWTGCYAAASPSSYWAPSAWCCSGSTDGPNCSHGCNSSFNNAASTSKTLASPGIVVSGSATSGPIIRPPGKPRPPSTPGTPWPQATDSGKIIQPRQPIATQTPPEARVATFNIPQLPAPPAPPEVISSEQDRQVQLQYELWLHNQQQILLQQQKYYETEVQKLRKSRKALNSRQRQLRKSGNELTEIDAAELQRISSEQSILQKQLDASRKQVRQHGMLAQEYKSKQQQRQTQPQTSEPCSPLMSPSQHSSPMHSPAGLVSHSPGPGSVPSMIQHSPVTIIQHSPNPPLLQHSPGTQQQQNPGTISPHNMQQSPRIGTPHSQNEESPFSPGAMPSPGLCGPTPRMTSPQHRAVISGRLTTSPGAFPQEVRQNQQIINEQGIRLQNTHQRFVRPSAPPSSPMPRSPMIPQTMGSPMLQQQLSQNSQPPSPMGSRIHPQPPSPMVSQYQPPSPMARSHPSTSPMLQHQLNNQHHPPPPPQTPSSPMPRSPMVPSPMQMQRRQSSGNSPAMPDRPQSVENPGTPRTPHTYTYNVQNSGHVNNDQQQQQQQQQQQQQMQQINQEQSNQSDLNQNQNRGGGNPHHPLTPIPIKSIFGRYGYFKPGLRGGSPMWSTKPECSKGKTVEPRITAATSNLNEDKPNTSSVVHRKTGISQSKINSLVHADYNDFDDDSHTPPQTPPTTETKTNTTSSLAVEKSVSSSLAIGSPDKLETMPDTTDYDDDKTIVNEEVTLSSTAQRDSDDTVIEELVDVSLGPVDPDEMQESFFLFEPVDLSNDSNDILSHALVNNTNQNHELVQILQIDPSQNDDSILSDDELVPSNRNKKTLRLDIMRTLQTGKRLVTVTDTPESPDQEDMAVDPSPVTSPFIDNPDDIMTLGEISASEVVIIDPTIKSPEDHLNKECEEEAEKIDSTFEVLQQPEQPNKSETNSDNLNEKKSFDLTEKMSSVSVSNSVSDPINDKDQVDAGEKTKIENSSASDVILESNTVCKTTETISKLVTTTITTMTTSITTIAATSTTNSVTTVASTKQVINLSDNQNQVLPSVISNVADIKVTSESNSQSLEISNSSTSPIITNTLTSCSSGNTNTNTNTNLKTKINSIDTVEPDSVASKILAQLTDNKDRSEICFSVANENVSLFPVSIENEVSSKLTVVPSTAVTLMKTKSSEAPKNNLIKSKVEDKKMVNISEKSKEKNDNLLNSVSNSNSNESLLSYSSSSPVEATTEEKKSDPLNTTDELESMLEAIHNPDENTSDSKKIICDNKPDISSFKRMSPVADEMSLVNILENDSELVINERKENKFQDTDQAKEPSVLHEKISVDKFTDNNEVEESSDVILDMLHNIISSKPEMANTNILEDQRKSTSMIYQMPMPLDTLPYNILQDSLMDFDQPIQDEQEPEEKTKQPPKSLDVPVTKTTPTPLVTSASIPTTVSTQISAPIQSTVNTMNTLQKPAAATTTTTTTTTTTATTTTAATVVTTAPTIAITTAIAITTTPAASTTAVPHLSPLSKPTELTSNMATASHQLRSLLSSIQTNHSSQNYTTAQAAIVTMVSSAMSNSKLGVSSPSTVSNSLNPQTSLSFRLQTVTSPASMSVKSSADTTTTFALQLKDNSVLSLGKTTASEFTKILTNTIQSQSINLPVVTTVRSTNSGISITSNAMLNAMLSVTPTVKPSIAGHRANTILTQTSNLLSSVLPTPSVQRNQNLQAILQVSSSPSRVNTVASTTTTKTTPLTSSATINVTTSILQSTLSQTTLLHSQLTSGSSNLYKSTEILPIDKTNEENVPTSTAKDDEIKTHDSEMPKQNHRIEDSNVLLKQLLQNTRCATTSLVANTSSTTTIPTAPSLEAQLARPVVSTVSSALLPQLVHKTPTVKPITKQLLTRETSFVSQQTTLPQKTPSPPIKEDPPTPRVTTPTAVQSLSPRGTVDTKHIQLNTLGKLTPSLSSAVTLTSSTVTAAIPVKPSQIKLEPGLITHQEITSQSSPLKPSSMSESSSSSSSSQSSSSSVITGQNQSQIRITQVPTSFTKLVSTLSKPAMTIAAPLKTVQAATPQVPSNVQQSSQPSTPVATTPPQTPLSTTPTLISAQKSVPITIQQSQPMQQQQQQQQQQQQQQQQQQQQQQPQPQPPQQQLPPQQQLQQQQQQQSQQPQQQQQLQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQHDQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQKLTHQQIQPTVPQTMTQNLSHQVHLPQGTITQHTVPLVEVKKEILDEVLSGNITPQLSDTKDFLTAKEELMDGSIDDKTDLRKLKRRQYQQKRRQSQGKDASTPPQKKRSRKVSRLDEDYDTFIENLMIQLRQLQAIPVLEPYLGRNYGVCPIYGSGDLSKLCTQKDYNPRTGDLLGVYGAARLPGVSDHYNTQPFGELEPLPAPQPVSTQRGFYDQEFPPLKLEDASDKKDCMSLLTRDVDTPDTIVSSSSPECVIPEFVHNFPGLRLIDDNSDEESDWLKRVSPVIPIISPIPIRLKTPATMAAELAAVKATTTAINTSVTTTPAVTVAAAAAAVIKDTAKQDKENLGITRIGKSPPVALRENSNVTVTLTLNSQAADDIMRVLKDLANILNISPPNGYQVVERTTTPPSQKLGLYRTKGKDGKEGAPVDIQSILNGAAKFCRHCDVVILNSLIRKKVSELPFLSKDEAEPGDELCFCSVSCYMQFALIHRTPITTQGKAATIVDHLGQKTDSKLLDSTLKKKLEEKKLIEKQMLNLAEINMEPMDICNAIKIKTEKEDLDLHDHIKQELVDKRPKKHPADLPTDLEFEPPSKLLRGTKYKVWSMGVLQPTKKYKKPSDKDITDLLFRMAVTVNPAKNEDSRRCMFCQNQGDGAADGPARLLNFDVDKWVHLNCALWSEDVYETVNGALMNLDTALQHSLAMNCIVCEKPGATVKCFKMRCTNVYHLGCAEKAGCVFYKNKSTFCSQHVQKNEKDNELTTLSVYRRVYVNRDENRQVAAVMHHTERNHLLRVGSLIFLNVGQLLPHQLPNFHTPHYIYPVGYKIVRFYWSMRQPNKRCRYVCSIHDKDGLPEFRILVQESSHEDSEYVGKTPRAAWEHILEPLSKLRESTNSIKLFPLYVSGEDLFGLTEPAIVRVLENLPGVDTLTDYNFKYGRNPLLELPLAVNPSGSARTEARLRNQLPWKRPHTQRTGSSARATFSPTNTVAGETTCPYSKQFVHSKSSQYKKMKQDWRNNVYLARSKIQGLGLYAARDLEKHQMLAYDYKFDIEDDQHKIACACGAPNCRKWMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HA72</accession>
    <name>A0A8J2HA72_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Similar to numb: Protein numb (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HICCMSTLAB_LOCUS3843</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5083454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HA72"/>
    <dbReference type="OrthoDB" id="10070446at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01268">
        <property type="entry name" value="PTB_Numb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000031">
        <property type="entry name" value="protein numb isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016698">
        <property type="entry name" value="Numb/numb-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010449">
        <property type="entry name" value="Numb_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006020">
        <property type="entry name" value="PTB/PI_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47368">
        <property type="entry name" value="NUMB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47368:SF2">
        <property type="entry name" value="PID DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06311">
        <property type="entry name" value="NumbF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00640">
        <property type="entry name" value="PID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017607">
        <property type="entry name" value="Numb/numb-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00462">
        <property type="entry name" value="PTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01179">
        <property type="entry name" value="PID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PID" evidence="4">
        <location>
            <begin position="80"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="308"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="481"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="38"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="481"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="500"/>
            <end position="509"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS01179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAG5083454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="655" mass="71477" checksum="29C75B29D6CF55F4" modified="2022-05-25" version="1">MGNHPSAHQPLERATSYSGNALRFSKRERSSPANTNSRRMDRLRRSFRDSFRRRKDTHIPESSKPHQWQADESAVRSATCAFHVKYLGCVEVFESRGMQVCEEALKVLRNSRRRPVRAILHVSGDGLRVVEDETKGLIVDQTIEKVSFCAPDRNHDKGFSYICRDGTTRRWMCHGFLALKESGERLSHAVGCAFAACLERKQRRDKECGVTMTFDSKTSTFTRSGSFRQPSLTEKLQDSRERAVDVPSTPTSAVAKQVYNPFAIERPHATPSMLERQGSFRGFTQLNQASPFKRQHSLRVNELPSNLERTRSHSLEPTDFSRLPTSLGGTLPHGIIGIKPPVSPIPEVQPSTGSEISAMCHQLSQGLSLLSSNDDFGPPSLSSLHSVSKNLFGNTNQAQGVTSSNSLDDMKLSNGPSINNNINNNNNNNNINNINEDESMDVAINDITWNETSQITLTNHQRLTPILNTSCNLSPVLVKTSSRPVSSAGPTESAIDRSTDTSMTSHQSFGINNSLTSSIASDRMETQSVISTSSATTSGISELPRPEQWLGTVTGLVSAASQSSGSGIISTVPSVPKVPIPPRRAPLLHARAHSLGSSIMPSTISTRSGIITTDPFDAGWAELAAPDLTKSSGSTATTTNPFIVPNPSQTFQVQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HAE8</accession>
    <name>A0A8J2HAE8_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS5636</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5090451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HAE8"/>
    <dbReference type="OrthoDB" id="7701485at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5090451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="135" mass="15712" checksum="2F2D6AE31B92C323" modified="2022-05-25" version="1">MGHFMPNRPLLNSTLFDFSEILEPRLAGKPTELGLEDFSQENPDWAKRIQRLNELRHKIEVNMEKDTERRQKDKDQEIQFPDVHVGDLVYYPNRKLSNKSQNYSAGLGVKYLGPAKVYKLISPIVVELRSAWQSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HAN2</accession>
    <name>A0A8J2HAN2_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Similar to ANAPC5: Anaphase-promoting complex subunit 5 (Pongo abelii)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HICCMSTLAB_LOCUS4209</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5084828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HAN2"/>
    <dbReference type="OrthoDB" id="2504561at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045842">
        <property type="term" value="P:positive regulation of mitotic metaphase/anaphase transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070979">
        <property type="term" value="P:protein K11-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037679">
        <property type="entry name" value="Apc5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12830">
        <property type="entry name" value="ANAPHASE-PROMOTING COMPLEX SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12830:SF9">
        <property type="entry name" value="ANAPHASE-PROMOTING COMPLEX SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1" id="KW-0132">Cell division</keyword>
    <keyword evidence="2" id="KW-0498">Mitosis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0833">Ubl conjugation pathway</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAG5084828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="419" mass="47383" checksum="DF11861B74382C94" modified="2022-05-25" version="1">MRFIDSLRSEILQKMETSNFGNLIHLIERSIGKSGAFGITHTTSLGLMASAHHAALDANSPTDVFETLMKSDALNSKHSMSDLMSMTYAEKSALWAYYGKAKMSTICAQLLLLHNSQNNKQNLFNGESTCQEVTNIINALVENGEYKLVDVVLNHAKERFNNLISNKIWISSERLFEFMKIMRHERWSEAENIANQISSLLPFESKLRFAEITIATGDYVAGLKLLSNTEENTILTASNRIQLMIVLSKILNLSAVSDQKFTSVNTFVLLNSALKIARTYHLSYYEAVIKMNLATLQLMIGMPNQALVLINEAMEQILAHGSCFDRGWAFTLNAQCLVATAPLDSKKRKLILQDAIEYLLKAKSYFQKIEAFSRIKSTTYFLSLIYNELGMKTKRNQFAFEYRQNNGENVIKSKIVTLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HAW7</accession>
    <name>A0A8J2HAW7_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">EB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS5422</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5089902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HAW7"/>
    <dbReference type="OrthoDB" id="10339538at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006149">
        <property type="entry name" value="EB_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01683">
        <property type="entry name" value="EB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EB" evidence="1">
        <location>
            <begin position="84"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5089902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="144" mass="16273" checksum="A6B938B49701BA54" modified="2022-05-25" version="1" fragment="single">TIIFQKEEIDAKMKINIILTIIIGALTQIGSLSPTFDDSRCTYTGADCPSMPCCNSKFECKLTTLSLFSLPPELYELAAKNKTYRCLEKIPLGRSCLFHEECSHIQYARCINSSCQCPSIYFEFQGQCFTWHGYDGSKVVISRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HB40</accession>
    <name>A0A8J2HB40_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein cereblon</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Protein ohgata</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">HICCMSTLAB_LOCUS4588</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Substrate recognition component of a DCX (DDB1-CUL4-X-box) E3 protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Has an essential role in mediating growth by negatively regulating insulin signaling. It also has a role in maintaining presynaptic function in the neuromuscular junction synapses of third-instar larvae.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Likely a component of a DCX (DDB1-CUL4-X-box) protein ligase complex. May interact with pic/DDB1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CRBN family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5087717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HB40"/>
    <dbReference type="OrthoDB" id="267517at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd15777">
        <property type="entry name" value="CRBN_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.150.20:FF:000005">
        <property type="entry name" value="Blast:Protein cereblon homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1480">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.130.40">
        <property type="entry name" value="LON domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.150.20">
        <property type="entry name" value="Peptide methionine sulfoxide reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034750">
        <property type="entry name" value="CULT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003111">
        <property type="entry name" value="Lon_prtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046336">
        <property type="entry name" value="Lon_prtase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004910">
        <property type="entry name" value="Yippee/Mis18/Cereblon"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46732">
        <property type="entry name" value="ATP-DEPENDENT PROTEASE LA (LON) DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46732:SF8">
        <property type="entry name" value="ATP-DEPENDENT PROTEASE LA (LON) DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02190">
        <property type="entry name" value="LON_substr_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03226">
        <property type="entry name" value="Yippee-Mis18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00464">
        <property type="entry name" value="LON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51788">
        <property type="entry name" value="CULT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51787">
        <property type="entry name" value="LON_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="6" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Lon N-terminal" evidence="14">
        <location>
            <begin position="18"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="domain" description="CULT" evidence="15">
        <location>
            <begin position="243"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="359"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="359"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00046075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00046796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CAG5087717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="385" mass="44081" checksum="7C689942E47127F3" modified="2022-05-25" version="1">MELEEVIEDQDEQDDEILNVDDESTWLKWLVLFPGGTLPIVERNSRPIDMLRQCIAKDRTFGVACIRNVNSIGTTAEIYEYTEESRMQGLDEVRVKAKGRQRFKIIRMKNITGRIPVADVKILPEIELGPPNYQCRIASLDRLRGGSNIKRLNKVSRIDSAITPWPSWVYNLYDPKKLSSRIHNYLKFLESKGGNIPSDPTDLSFWVAQNLVITPKTALSLLEIDSVILRLQREEKLLRKLANNVFVCKRCGAKVAKQTDVFQMNEEGVQSAYCNPAGAIHETITLHKAQSLVLDNAPPSSEYSWFPGYQWTIAHCGGCRSHMGWRFTAAQRDLKPQSFWGLTRTSLVWGERESHYCDEWDSDDENNESTDQSDTEFLPPYSNIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HB57</accession>
    <name>A0A8J2HB57_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phenoloxidase-activating factor 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Prophenoloxidase-activating factor II</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HICCMSTLAB_LOCUS4633</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5087877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HB57"/>
    <dbReference type="OrthoDB" id="5918597at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000038">
        <property type="entry name" value="Serine protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033116">
        <property type="entry name" value="TRYPSIN_SER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24252">
        <property type="entry name" value="ACROSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24252:SF7">
        <property type="entry name" value="HYALIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00135">
        <property type="entry name" value="TRYPSIN_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="6" id="KW-0720">Serine protease</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035324326" description="Phenoloxidase-activating factor 2" evidence="7">
        <location>
            <begin position="29"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="8">
        <location>
            <begin position="77"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00068096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00076468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAG5087877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="310" mass="34617" checksum="359C4C4FAE0D2CE2" modified="2022-05-25" version="1">MQQHTRERVLLALLFHLLAVSLLGYGHADHGHTDPILFNTIGHGRIFEEKSNFTKDTWRTGRGPRGCGVSSKGWTRVVGGQPANPKEWPWMVALIRRDSDQYCGGVLITDRHVLTAAHCLYGVKIRNIIVRLGEYDFSRPDETRSLDFRVVDVKIHENFNPSSYENDIAILKINRPTIFNNYIWPICLPPEGTSFENKNAIVIGWGSQYYAGPQSSILMEVPVPVWPKHRCAHTLAQRLPDSIICAGGYEGGRDSCQGDSGGPLLHQLGNGRWVNIGVVSWGIRCGDPGHPGIYTDVSSFLDWIFGNAIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HCM4</accession>
    <name>A0A8J2HCM4_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">HICCMSTLAB_LOCUS7341</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. DMPK subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="23">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5094015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6764942at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031032">
        <property type="term" value="P:actomyosin structure organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20809">
        <property type="entry name" value="C1_MRCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00132">
        <property type="entry name" value="CRIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01243">
        <property type="entry name" value="PH_MRCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05597">
        <property type="entry name" value="STKc_DMPK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000014">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.20:FF:000005">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:001055">
        <property type="entry name" value="Serine/threonine-protein kinase MRCK beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046349">
        <property type="entry name" value="C1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001180">
        <property type="entry name" value="CNH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000095">
        <property type="entry name" value="CRIB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020454">
        <property type="entry name" value="DAG/PE-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031597">
        <property type="entry name" value="KELK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057529">
        <property type="entry name" value="MRCK/ROCK_PH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002219">
        <property type="entry name" value="PKC_DAG/PE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017892">
        <property type="entry name" value="Pkinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050839">
        <property type="entry name" value="Rho-assoc_Ser/Thr_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22988">
        <property type="entry name" value="MYOTONIC DYSTROPHY S/T KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22988:SF66">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE GENGHIS KHAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00130">
        <property type="entry name" value="C1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00780">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15796">
        <property type="entry name" value="KELK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25346">
        <property type="entry name" value="PH_MRCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00433">
        <property type="entry name" value="Pkinase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00008">
        <property type="entry name" value="DAGPEDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00109">
        <property type="entry name" value="C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00036">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00285">
        <property type="entry name" value="PBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57889">
        <property type="entry name" value="Cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50219">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50108">
        <property type="entry name" value="CRIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00479">
        <property type="entry name" value="ZF_DAG_PE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50081">
        <property type="entry name" value="ZF_DAG_PE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12 16" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9 23" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <keyword evidence="8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Protein kinase" evidence="18">
        <location>
            <begin position="112"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="22">
        <location>
            <begin position="380"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="19">
        <location>
            <begin position="1161"/>
            <end position="1211"/>
        </location>
    </feature>
    <feature type="domain" description="CNH" evidence="21">
        <location>
            <begin position="1354"/>
            <end position="1632"/>
        </location>
    </feature>
    <feature type="domain" description="CRIB" evidence="20">
        <location>
            <begin position="1692"/>
            <end position="1705"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="526"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="965"/>
            <end position="1026"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1100"/>
            <end position="1134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1724"/>
            <end position="1876"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="16">
        <location>
            <begin position="550"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="536"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="974"/>
            <end position="1022"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="1119"/>
            <end position="1134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="1727"/>
            <end position="1741"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="17">
        <location>
            <begin position="1751"/>
            <end position="1764"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="1774"/>
            <end position="1786"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="17">
        <location>
            <begin position="1795"/>
            <end position="1808"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="1826"/>
            <end position="1835"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="141"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="CAG5094015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="1876" mass="211241" checksum="4494991D0D00C7B6" modified="2022-05-25" version="1">MASTKDPDKGSNRIKAQIMSNPTEHSFPMDIVSGGVAGRLRQLENLFISGPVQGGKIGHTFSIETLIDVLLILYDECCNSSLRREKTVSDFIEFVKPVAACIKSLQLCREDFEIIKVIGRGAFGEVCVVKMRESDKVFAMKILNKWEMLKRAETACFREERDVLVYGDRRWITNLHYAFQDDNNLYLVMDYYCGGDLLTLLSKFEDRLPEDMARFYIAEMVLAIGSIHDLRYVHRDIKPDNVLLDANGHIRLADFGSCLRLFEDGTVQSNVAVGTPDYISPEILRAMEDGQGRYGPECDWWSLGVCMYEMLYGETPFYAESLVETYGRIMNHKNCFDFPTDDTYDVSDEAKDLMRKLICSSEFRLGQNGIEDFKKHPWFNGVNWDTLRDSTAPYIPEVSSPTDTSNFDVDDNDVRSSDAVPPSANSAFSALHLPFIGFSFTQGSCISDLGSLTVLPPRKDKSIEVLEEENSRLLQSMADLKNQLAVGTTTTPPTVSPDSNTATRKLQDEINTLTKRNCELESQLKSLETNSSAAQRDLRSKDNGGDVGKIQELEKLIRVLRAEKEEATKEKLDTQEKLKLQDKELKDALTQRKLAMAEYTEVTDKLSELRQQKQKLSRQVRDKEEELEVVMQKVDSLRHDIRKAEKLRRELENRVEEAMAETSKERKLRERSEEYCKQMQEETEKIRQRSVGNDASANHALATQEINRLKSEVEQLEIQYNENLSQQQSRYNTEIRSLQEQLHEAESRRELLEREVQVTKDKLDAARLENITDSEETISELSRRHEREKIMLAEENKKLILELNSMTDSVNRIQGERRQLEEEYEELRNKKEAIAQWEAQITEIIQWVSDEKDARGYLQALATKMTEELEFLKHSGGVGGVGSTSTMSDKNWRNRRSQKLDKMELLNLQSSLQSEIQAKQAISEELTKTRSDLIAAQKELRDFRQRMDSMSHEVKRKEMQIKELQSRVETNDGSVLLSTTVPSSKLSPSPSTKSASTSTSSSPTTITTTSTTTSSSSTSTSANKHIIRTKPQRIIVHQPSSPLPVIRSPRITTCRLLTRFATVNSIINRNAVAIVSSPVLERPTSQMSYLEHFLKETAGSTRHGSVDSVEGDIEDNRAPSLTSSKSNLSELSIDPTSPLSHELLNKSSAHSQAALQPKPKSHQFLVRTFSAPTKCNHCTSLMVGLTRQGVVCEVCGFACHMPCCDKVPAMCPVPHDKIPKMGGVKKGWIRQFVVVCDFKLFLYDISPDRNALPSVYVSQVLDMRDSEFGVSSVRESDVIHATKKDIPCIFRITTSLLEPPGLRNHTLMLADTESEKTKWVVALGELHRILKKNNLPNTTVFRAKELLDNTLAVVKNVMSGAIIDPDRLVIGTEEGLFCLDLDRSEVAKVGEGKKIYLLEYITEEQLIVVLSGKQRHVRLVPVRALDGDEVEWIKVAETKGCITLTTGLVRRNPLTYCLCVAIKKQNASHVMIYEVTRTKTRHKRIHELMLPCHAQTLQVLSEGRLCVGYPSGFSIYSILGDHHPISLVHPENTLLGFLTYSAVDAMRCIELPRGEFLLVFQTLAVYVDSQGRKSRDREIMYPAVPTAVSYCEGYLLIYSETHVDVFDCTTGDWLQTLNVKRARPLNISGSLTTSLINDMPYVIHLSNLHQRELLNLIPVDGSGRQITRPRRRFSLREGNRGVRPTDRRSKMISAPTNFNHISHMGPGNGIQIQRLLDLPTTLETADQQQYSSHHSASHLHQNPQQRFYGPVQPPSKPAPLPPRHPPSDTRRLSSHMSRNSGYSPHNGSTSSRRGPAPPRPTATPPSLPRTPVDQTESESLHMRSHTPLSLGSIASLQDKDHATGGSPRHSIASNNSSNPSTPPSPAHDHGSSSYDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HCP2</accession>
    <name>A0A8J2HCP2_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">WD repeat-containing protein 89</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HICCMSTLAB_LOCUS7109</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5093783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HCP2"/>
    <dbReference type="OrthoDB" id="25131at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039328">
        <property type="entry name" value="WDR89"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22889">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 89"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22889:SF0">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 89"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 4" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="190"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="374"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00021125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAG5093783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="402" mass="44720" checksum="CDC441D984F22ECF" modified="2022-05-25" version="1">MPNMIENTEKREGENGEIQDNNISNKSINRCEMILSMEDTISTEDNYILGICGTQSEPEFRICAALSDYSCVVYNVGEQLSKILKLDHNTSPIVGVKFCNGSKNILYTATKHGSITACDLRAKGKPVAELKDNSSEGKLKPLASFDISCDDRLVAAGTEHIGGDAFILFWDIRFNNSKFDSKNNLLGGYWESHMDDVTSLAFHCEKENVLASGSTDGLINIFDLTQTTEDSALNYSLNTESSVDRVGWLEDGNIWCTTHTHSFQMWKCEDASPFIKYNRSCIANFLNEDPDSCYLVKMNKSESIDHSFLLTGSSSVKGENLSGVIVNSDGMEICYDFIGNKQIVRDSWLHSKSGCMITGGESSILNLWKQSPESLSIPRHSERKSIAKSNGKARDKHRTKPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HD90</accession>
    <name>A0A8J2HD90_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Similar to SGF29: SAGA-associated factor 29 (Homo sapiens)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HICCMSTLAB_LOCUS5226</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5089408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HD90"/>
    <dbReference type="OrthoDB" id="10265994at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140672">
        <property type="term" value="C:ATAC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20393">
        <property type="entry name" value="Tudor_SGF29_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20394">
        <property type="entry name" value="Tudor_SGF29_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.140:FF:000026">
        <property type="entry name" value="SAGA-associated factor 29 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.140:FF:000029">
        <property type="entry name" value="SAGA-associated factor 29 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037802">
        <property type="entry name" value="SGF29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010750">
        <property type="entry name" value="SGF29_tudor-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047288">
        <property type="entry name" value="Tudor_SGF29_rpt1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047287">
        <property type="entry name" value="Tudor_SGF29_rpt2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21539">
        <property type="entry name" value="SAGA-ASSOCIATED FACTOR 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21539:SF0">
        <property type="entry name" value="SAGA-ASSOCIATED FACTOR 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07039">
        <property type="entry name" value="SGF29_Tudor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51518">
        <property type="entry name" value="SGF29_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="SGF29 C-terminal" evidence="6">
        <location>
            <begin position="148"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAG5089408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="292" mass="32832" checksum="05A1B2D14E7A1438" modified="2022-05-25" version="1">MPFTADAAAHQIQERLKSIYQLVKDIDTERTRSEVNLNNITKAHEKVTPDDKITPYYQQKLKTLYNSAIQDAQQEEELLRSALSKINEIRAIRNERRIQARNAGNKETIRRGALMKMLQSTAATLPLYVGKTPGAKAPPLCGAVPAESTYVAKMGDMVAALVKSSSDEEENWILAEVVHFNSTTNKYEVDDIDEEQKDRHTLSRRRVVPLPLMRANPDTDPHALFPKGSIVMALYPQTTCFYKAVVNQLPNSATEEYEVLFEDASYADGYSPPLNVAQRYVISIKEGKKSKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HF26</accession>
    <name>A0A8J2HF26_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Mitochondrial (Danio rerio)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS6389</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5092825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HF26"/>
    <dbReference type="OrthoDB" id="6073372at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050684">
        <property type="term" value="P:regulation of mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034629">
        <property type="entry name" value="PTCD2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14700">
        <property type="entry name" value="PENTATRICOPEPTIDE REPEAT-CONTAINING PROTEIN 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14700:SF0">
        <property type="entry name" value="PENTATRICOPEPTIDE REPEAT-CONTAINING PROTEIN 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="342"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="342"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="356"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5092825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="384" mass="44242" checksum="56751D6F707EC625" modified="2022-05-25" version="1">MAGTIRCISKFNINILNKLVKQQLIYNGSRTLYDEASLGLDNYKSTRNIVMEKYKIGLDSFKSKMQESIADEKAMIFTEDLKSTLHLVEKDDIQLLVSMLEKYNSQNSQVRFGTFKFGPVVMRTLYYLNEPEIALDLFLNPKYDEFFNQMSTFMLIMDLLYENKRYADLRTAYDKIKQKFVNGISHPKLVINIVAVACYKENTQESLEYGLNICKDLDHRGSIPLRKVIAALGALALNLKSPEVTLELVALSRTVDYISIRCIRIMALADLGRIDEIVIVLKSCIQRGIPEKNGFYTDVIPRIQEAMKRLKIDEDHEICNLIKVLQSQGYVTPLTLDEHLTQKIKTQPKDNEPSSRRYQSSSWSESSSEVNYYERQNRQGNTSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HF51</accession>
    <name>A0A8J2HF51_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="18">Axonemal (Homo sapiens)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">HICCMSTLAB_LOCUS8250</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Cilium axoneme</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the dynein heavy chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5096519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HF51"/>
    <dbReference type="OrthoDB" id="64868at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005930">
        <property type="term" value="C:axoneme"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030286">
        <property type="term" value="C:dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045505">
        <property type="term" value="F:dynein intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051959">
        <property type="term" value="F:dynein light intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008569">
        <property type="term" value="F:minus-end-directed microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.720:FF:000005">
        <property type="entry name" value="Dynein axonemal heavy chain 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.490.20:FF:000006">
        <property type="entry name" value="Dynein axonemal heavy chain 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.1220:FF:000001">
        <property type="entry name" value="Dynein axonemal heavy chain 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000320">
        <property type="entry name" value="Dynein, axonemal, heavy chain 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.1220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.280">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.720">
        <property type="entry name" value="Region D6 of dynein motor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035706">
        <property type="entry name" value="AAA_9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041658">
        <property type="entry name" value="AAA_lid_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042219">
        <property type="entry name" value="AAA_lid_11_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026983">
        <property type="entry name" value="DHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041228">
        <property type="entry name" value="Dynein_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043160">
        <property type="entry name" value="Dynein_C_barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004273">
        <property type="entry name" value="Dynein_heavy_D6_P-loop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22878:SF63">
        <property type="entry name" value="DYNEIN AXONEMAL HEAVY CHAIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22878">
        <property type="entry name" value="DYNEIN HEAVY CHAIN 6, AXONEMAL-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12781">
        <property type="entry name" value="AAA_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18198">
        <property type="entry name" value="AAA_lid_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18199">
        <property type="entry name" value="Dynein_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03028">
        <property type="entry name" value="Dynein_heavy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0966">Cell projection</keyword>
    <keyword evidence="9" id="KW-0969">Cilium</keyword>
    <keyword evidence="8 13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-0243">Dynein</keyword>
    <keyword evidence="4" id="KW-0493">Microtubule</keyword>
    <keyword evidence="10" id="KW-0505">Motor protein</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dynein heavy chain ATP-binding dynein motor region" evidence="15">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="domain" description="Dynein heavy chain region D6 P-loop" evidence="14">
        <location>
            <begin position="321"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="domain" description="Dynein heavy chain AAA lid" evidence="16">
        <location>
            <begin position="464"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="domain" description="Dynein heavy chain C-terminal" evidence="17">
        <location>
            <begin position="618"/>
            <end position="913"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="15"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="18">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF03028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF12781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF18198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF18199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="CAG5096519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="916" mass="105730" checksum="F07012B9F0C72BC9" modified="2022-05-25" version="1" fragment="single">ALENKLLSIVMGLEKSDIEEKKNKLTTQINAIKSSIKKSENEFFEKISTSRKPLLQDIDLLESLGKIKANIREMTLKIDQNKNAAADIEEISESYRPVATRGAVLFFVLFDLAALDPMYQYSLSSYLELFTRLLKQAPSLNMSITERIDSIIETLTINIFDYGCLGIFQKHKVLLSFHICTKIELSIGCISQEELNFFIKENTSVESSQRNHIQWLPSSSLADIFQLSVGFGNFSDLYNELQVNSNDWYRWYKLDTPESSPYPGEYSKKLHPFQKLMLIKCFRIDRVYCGIIKYVTDCLGVRFITPRIISFKTIYKQIDSYIPAVLILSPRVELTSEFTTLAEFHGFNAEKLMIIFLGKGQEKKASKLLEISMTKGRWLVLRNCHLGLEFIRKLEAKINHMKKPHDNFRLWLTTDLINDFPIGVLQRSLKVVLEPPSGLKLSLKNTYLKLQEENLKSCSHSKYKHIIYILAFFHAIVQERKRYGKIGWTINYDFSESDFIVCTSIIGTYLTNLSPTSDFPWASLKYLISEVIYGGKVIDRYDHRIVKVYVDEYFGDFIFDTSQPFYLYKKNETLHSVPLDGSKDDYISFIDNLSISDSPEIFGLHLNAENTYFVRNIREMLINLNKMTSQQSINSLSKLNPEELIDNVSKDVLNKIPSEFNMAKVKHNFGLDVTPSVIVLFQELERFNKLIKTINTTLTQLRNAIAGKTNFTTRMESISASLYNGELPKEWARLAPATKKNLANWMIHINKRKNQYTDWSGSNEPIVMWLSGLHVPESYIAAFFQMSCKKNNWPLDNYSIYTTVSKFSKFDEIEERLCESCNVHGLFLEGARWDREQHCLKQSYSKVKFDELPVLCITTKKSLNIHLENTVKTPVYVTTDRENTMGEGMVLEADLKTIEHNSLWILQGLCLLLNID</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HFD1</accession>
    <name>A0A8J2HFD1_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to Ajm1: Apical junction component 1 homolog (Mus musculus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS7477</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5094974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6431454at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043296">
        <property type="term" value="C:apical junction complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045216">
        <property type="term" value="P:cell-cell junction organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058586">
        <property type="entry name" value="Ajm-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038825">
        <property type="entry name" value="Apical_junction"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21517">
        <property type="entry name" value="APICAL JUNCTION COMPONENT 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21517:SF3">
        <property type="entry name" value="APICAL JUNCTION COMPONENT 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26649">
        <property type="entry name" value="Ajm-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Apical junction molecule ajm1 alpha/beta" evidence="2">
        <location>
            <begin position="1818"/>
            <end position="1932"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="579"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="908"/>
            <end position="935"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="963"/>
            <end position="1002"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1164"/>
            <end position="1233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1352"/>
            <end position="1399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1459"/>
            <end position="1493"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1517"/>
            <end position="1539"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1622"/>
            <end position="1641"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1682"/>
            <end position="1755"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1955"/>
            <end position="2042"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="579"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="965"/>
            <end position="983"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1177"/>
            <end position="1191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1368"/>
            <end position="1385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1476"/>
            <end position="1487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1527"/>
            <end position="1539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1702"/>
            <end position="1721"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1728"/>
            <end position="1738"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1956"/>
            <end position="1978"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1993"/>
            <end position="2021"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="2029"/>
            <end position="2039"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="2165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF26649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5094974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="2165" mass="244504" checksum="6E1C75C3A7B855F7" modified="2022-05-25" version="1" fragment="single">MSSNNNQCMIMTTPVHHKVDSEDNELSGNSYIENNDMLNDVDLVNGPNPWLPAYGYQIQHQQTYNRPTHEEQSNENCLSQQIDFLETIFEETSEDLQSDSDRSDGEQLDSNESECNSMVPDKCRCQNNTTECYCWCKSSSTALMKDNNRWSTLPRSLSRSSTSSCSSSLVQFENNERACAAVSPSGYSYDSLEYSNCSNSYFDNTSPDSLEDSETENYNPSKRFDSNNDNVQFFAKIRPYKSFESLDTSCDNSQFVGMTTFKQPKLKRDVWEPRYDEEKNYLRSTLDSDNNYRHQASMEWTSTIDLREIGLESDGREAVLLNLTRSQVGSFSDSPYTKLNIDYSSNNQPSRIIPVEQRGWSNSMSSDFNFRFTNKSRSVPSLPTDLDGLSTDYLTRNLYCNDIYDTSVSNTGLSSFKYSENFTRVNSVPVNLNLFGSFDTANEQVVSITYDSMNSEHNNCEMADYQPNEMAHYQFNTIISNNTEDNDIIAKGKVKEIPSIENETEQIDNNCDISSSAILKENINDESNNIVKKKTVKIQDRGFDVLTIENNIDAVVDEAIRQLGSKVEEIITSPDNMEQVKDSIPRTPSTKDRSRRVKNNASYELAQQWEIDDKIFKYSPSSSAAGYSSPNTRKRVLNNASYELAQQSDYIKALHLTSRPFQRMDACDELNEAGFGDQKCGASSSAGAGDRNQSDDNNLLSQIKKNSVCFSIYGETGNCIPNAVGPILDDEVDFSYLETKVIANEPVIREFESLLLSTGNDNNSNYSNEQKEEEEEMDINCCDNLTNNSNKKLNDFEVENNSEDPELNEFCISNEMALLVDNSNLKVNGAGINEGVFTENNRQNPQPIEEEEKLPMVLVEESILKKNPSEVGEITRQQHKQQCTEPKPTQQNIVNTTSVVCNHALTSESNTRSGNSIVGRDLDECGTESEGKKEEVIYEGSDNQPWSKPMLVMLTKSLENDRLDSTTASLSTTKSTVPTTRSTMVTVPPASDATMSEDDKNKKSRIGGFLQRFSKFRFSGRSKSPRLDASNKKSKIITDTRSCGTQSVNVGKRVAEHNYIIIPLHAPEEETNNDQRRQQQQQQLCEISKNTSVADNNPELNASSVGTNGRAAVCMNKPPLPPLQNVRACASASIRSTSSPEPAGTRRRAITDLGNPAIIKMAKARAMQQQQQQQQQPHHHHLHHLNYHQHHQSASQMKDHPGGLLETDLDADIHHGEPDINDGSIINDGASTTDKKTRSLLNLTHTSRQGRENVLLRVPQSPAGFSCDGNTSDHPDYDVTGEHINHNRPHKSMEFLLDKENLHFIKPPENELQKGMAAERVPSEHELRVQRSLQRLNVPDWYKNSPAARDGFRLKRHSDASQHSGWRSLGSKTTSLSSLSSSSNLRQPSRGLLSSPTPQPVFSRWSTSLLNSAGSSPANSIGSSFNYRQPYLGWRSQERLANPRTPAERLAQGILPQLDPKQQQQQDHQQHHQEQEQQQQQQQQQQQRTSHQLDVRNSIKEVTSAIVHYVQSGQEATVKGGRLSPRFNDDNNDDRSDNYHHRNYEDRFASPRGEGIKMCWMESSFVGTRPVDSPETPVSLTADKECSCTGCDATGTTKSCSCIESTTNSGLYLDLAQSDASNCPSPSSSYHRDTSQQRYSHHREMMEDMKDTQTTAMTAAFFRNKPSPGSTTLEDVLDSLLGLPSASSRTPSPGGKTGKSCSDLRQDLQESVKQDLTESTEKPNLNNERSKDRRKSEGSDIVPLSHRNISSSRNRRVSFDNTATVDKYLVKCRHNKCNNTTTLVEARRVYKSCHYCMYLYCSRDCRRAHWQRHRKTCLHSRVGAICRQVLSSAKDDPATLKHISLLARHGYMAHGRGAVKFFFTSPELAEKFISNGFKDLGEPTYVRSSDLLLSEMGTELYAEVMRLCKSYNPETRLVLYVAVCVVNEVPSTDVGGVRWERQLISRCGKIRLDAKPHHHHHHHHHQHQHQHQHQHQHQHQQQQPHQSRHQHHQQQQQQQQQQEHQQQQQQQQQQQQQQQQQRQEHPKESSSSQPTSSSPACNITREMESPETLVFTSLPQSNSAGEPETTPKKIREIGFANIQRQLRLRGVSLRRHFPQVYKKLCSYVDGSVDKFAPVTIYPIDQASGKSFMCIIMLDVEPERLRLLPTDSSRVKTIDISAIEQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HFD8</accession>
    <name>A0A8J2HFD8_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Mitochondrial (Rattus norvegicus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HICCMSTLAB_LOCUS8738</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the thioredoxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5097499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HFD8"/>
    <dbReference type="OrthoDB" id="19690at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02947">
        <property type="entry name" value="TRX_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43601:SF5">
        <property type="entry name" value="EG:132E8.3 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43601">
        <property type="entry name" value="THIOREDOXIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="38"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="76"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="3">
        <location>
            <begin position="95"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG5097499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="220" mass="24499" checksum="11BC1BAC6B20EC2A" modified="2022-05-25" version="1" fragment="single">MVMTTLILGIGVGLFVILTLWLSAALIFAVSFRIDKKIGAIAIIVAVIITIVLVSVPRSSEYPSSFQEKPYDQLFVWRVILLTVLVGSSLIALFGYVKYELMDFKKPQRINTEFVSKVMNSKVPVIVNFHAEWCDPCKILTPKLEKLIGPMENLNLAIVDVERNPELVHTFEVKAVPAVIAVSNGLVIDKFIGLVDANMIDNLIKKLTESTSNTHNYPKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HFV8</accession>
    <name>A0A8J2HFV8_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">FHA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS7085</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5093759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HFV8"/>
    <dbReference type="OrthoDB" id="206452at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00060">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045055">
        <property type="entry name" value="DNA2/NAM7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041677">
        <property type="entry name" value="DNA2/NAM7_AAA_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887">
        <property type="entry name" value="DNA2/NAM7 HELICASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887:SF495">
        <property type="entry name" value="HELICASE SENATAXIN ISOFORM X1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13086">
        <property type="entry name" value="AAA_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FHA" evidence="2">
        <location>
            <begin position="27"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="119"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="176"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="193"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="205"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5093759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="806" mass="92720" checksum="8F08921C8D263E3A" modified="2022-05-25" version="1" fragment="single">MNSYFLLEPLTSSQQTHPICLSHNKNYMCGQNPFNDVVIPNSMVSSKHCIFFITESGVKILDLKSNGGTYVNGEKIPPVTFKSLVTDDIIGFATDKTKNIDPQKFLVYRLLKMVLSRDSKENNGIKKSSKRKIDTDTSADEISDDDNHVSNNSSRRPSSYLKDNVAFHSSTPKLDNINEMKKNKKRKEDDNELNNTENKNNNQNKDSKTNAREKNDPSRNVKTYDKINIDKYDTEKANSDSVKIKGDKYKEEISTQEIQNKMDEREKIFFYELFKYSLAKMKESNKHHSNEFATEEISQQYSYDNYDQYDSIMTKLILQKAKSEISKNVNHENKNVDYFDVNLKPKSNKSYRIKPYNAPLTEYEIEMFLTEEEFEKKEYPCEYSFVILKHAMLPNNHDGNKYPVYNTIFAYTKKCLKTLLTPPPHHREYSTNTNTKQHALITYTIVTKQPFQPALHQNERLNLHSILLQNVCYLGNLVRMLRSIQFLQTSPLKNSVIKPKFDDKVFILPKISDKSHQLITGLRENDSIKRIILRIAAGLCGSDPKIFFLRVSSQIKLNIIGNIVTEVLYGTNKKKSQRILVCSPTNKLTDEVTNKLLDLNKELKHKHRMEIVRLGTTRVNHLETDVRLNKLLQNQSSYQDLLFSDAEKEKISILVEIKKYNCIKEQLYSNQQMSDDTPRGSHSKPKNLISRVSTLDEGTNNNLFNIKKKVLCEANVITSVSSSFFNKQMEMAFGIGKPDNIDVCIIEERFYGNGELETLLSLMLGVTKFVIIGNSYEPDDYVAKAQKNGNQTLFSRISGLFAGDSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HGE5</accession>
    <name>A0A8J2HGE5_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Similar to SERPINI1: Neuroserpin (Gallus gallus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HICCMSTLAB_LOCUS7179</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the serpin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5093853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HGE5"/>
    <dbReference type="OrthoDB" id="671595at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004867">
        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19601">
        <property type="entry name" value="serpin42Da-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.39.10">
        <property type="entry name" value="Alpha-1-antitrypsin, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.497.10">
        <property type="entry name" value="Antithrombin, subunit I, domain 2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023795">
        <property type="entry name" value="Serpin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023796">
        <property type="entry name" value="Serpin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000215">
        <property type="entry name" value="Serpin_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036186">
        <property type="entry name" value="Serpin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042178">
        <property type="entry name" value="Serpin_sf_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042185">
        <property type="entry name" value="Serpin_sf_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11461:SF211">
        <property type="entry name" value="GH10112P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11461">
        <property type="entry name" value="SERINE PROTEASE INHIBITOR, SERPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00079">
        <property type="entry name" value="Serpin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00093">
        <property type="entry name" value="SERPIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56574">
        <property type="entry name" value="Serpins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00284">
        <property type="entry name" value="SERPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0646">Protease inhibitor</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0722">Serine protease inhibitor</keyword>
    <feature type="domain" description="Serpin" evidence="5">
        <location>
            <begin position="123"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="domain" description="Serpin" evidence="5">
        <location>
            <begin position="474"/>
            <end position="808"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAG5093853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="811" mass="91929" checksum="9BD1421AD2CA67EE" modified="2022-05-25" version="1">MIVKQTRNPGHSLSMFVILPIKDGLEKTEQTLGYIDYRKLHFKAHEDNIELYMPKFKIASTIDLQPILDMMGMRRMFRDRTDFSGITDKFMKITKAVQKAVIEMSEENKALHTVASSINQFTTNFYKALARDESSNFICSPISVSMVLSMVTYGARGNTEKELRNALRLSDDDQVNKNGFQSLVDTLNAVEKVELRLANKIYFNVGFDVKTEFKELTEKIFRSVSEIIDFGKSAEAAETINTDLCDSQIVLINAVYFRGEWKWKFNPKYTEPEPFHIDENTVKDVPMMRKEARYNYNELPDLDAKIIELFYKSSDGNHPVTMFIILPNEVNGANKIEVNLHDVNFKDLHENAGEHMKECELQLPRFKVESTLNLKNILTKLGLNGIFEPSANFSGISESSQLSVSKVIQKTILEVDEIGSVAASVTVAVIMPKKGCLMEPTPFIVNRPFVCVIVATETGTPLFNAPTSLDKFSTNFYQALARDESSNFICSPVSVSMVLSMVTYGARGNTEKELRNALRLSDDDQVNKNGFQSLVDTLNAVKKVELRLANKIYFNVGFDVKTEFKELTEKTFRSVSEVIDFGKSAKAAGTINAWCEEKTNNRIKDFDPELTEPMPFYVDENTTKQVPMMYRKAHYNFGHIPEFEATYVELPYESTDSSDSISMFIILPTEMNGLKACERHLHEINFKDLHRDRARIEVELRLPKFKIESEFQLQDTLVKMGVKEIFENSADFGNITDSERLKVSKVIQKAFIEVNEEGSEAAAVTALIAVQYCLILDTPSITVDKPFICAIVATDTGMQLFNARINDPTLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HGK1</accession>
    <name>A0A8J2HGK1_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Endonuclease/exonuclease/phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS9812</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5100739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HGK1"/>
    <dbReference type="OrthoDB" id="1421278at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14529">
        <property type="entry name" value="Exo_endo_phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="2">
        <location>
            <begin position="109"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5100739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="872" mass="98939" checksum="D5892DE73952E167" modified="2022-05-25" version="1">MKKAKLNGTINITFWNLHGLGNIKGCSLINSSDILATCETWCTCPPSTPPTTLSNYNTFWANAVREHAIGRASGGLLTAISKKYTSTVLDITPWWIFNLIIAGSTTLIIGSVYFRKCLNLNYLLDLFQDTIDEIKTAHTYDAFILGGDSNAKVGSMNPWPEELFLDSALQNSMSSSDKSICDRGRRLMDFMLENDFVLLNGRTQSDVPAQPTFDGAGTSIIDLVWIDLPALHHVVDLEVVLEPTLSDHRPVNLKIAVDIAVDVENVKACNTRKPLTPSLRIKWSDNAKDDYSYHLANCISPISSNDLDSQYNSIHSAIFTAADKANLVMRRSNSGQSFSNEDSPWYDLECKLAKREYRKSLKIYKKENHSQPARTEAAKYKKIYRDICKVKQKEYNKQINDAFNAVSMPTNFWAAIRKLTYKTGLRSSIPIDSWNDFYSKVYSLRHIAPPILVRIFNDTLDSEITYIELNAVLSSLKVGKAAGPDLLPNEVYKSLTPHWKENLRCLYNNIVTFKAAGRHKECPEQFRRYKGTSLNIVKTYSYLGVKISSTTMGLSALKSATNKAKCATGATVALLARAKCDSLKVFTKLFDTMVASVFLYAFPAWGLWYRNSLESVQTQFYKRIYNLPRNTPDWVLHLEFGLTPVAWKAMHMLWNWTIKTLKNNESLFSKICLVRLFQLAKSSPQTQPFNWATQFREFLIECDCVELMESLDPCLWEDKTNSIFTKYRNILLNKDIESARISKSLEFGIQRPLQLAPAKYVVVKTSLTVKRIFAQLRLANKLYCQLIINNQIIRFTPNTSCQLCNLHDLDNIEHFLLKCPLFSALRNYHLGCFLGTDVPLSSLLNTTDIKTILAIVNFTEKSAQLRAWALNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HHU5</accession>
    <name>A0A8J2HHU5_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">THAP-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">HICCMSTLAB_LOCUS5704</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the THAP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5090639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HHU5"/>
    <dbReference type="OrthoDB" id="7555211at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.210.20">
        <property type="entry name" value="THAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026516">
        <property type="entry name" value="THAP1/10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006612">
        <property type="entry name" value="THAP_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038441">
        <property type="entry name" value="THAP_Znf_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46600">
        <property type="entry name" value="THAP DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46600:SF1">
        <property type="entry name" value="THAP DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05485">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00692">
        <property type="entry name" value="DM3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00980">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50950">
        <property type="entry name" value="ZF_THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="7 13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8 12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="THAP-type" evidence="14">
        <location>
            <begin position="4"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="221"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="15">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CAG5090639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="277" mass="31740" checksum="5DE75171D6DBAF7A" modified="2022-05-25" version="1" fragment="single">YSKVVNSCYLCDRKASRADNISLHRFPKNLDVHIKWLNACGLTINDDVRRTSTCSRHFKAEDICQSNIFGTVKSSIKRNAVPTLHLINPIIIDTSNKSQPNTPLSELFNENGVTNQSSYFPDNNVLDIVEKSPENFVELDNFEIQTSNKCNINSDGSCEQYDFNQSMKNTISNFSSEDENTVPGENNSPSQCRKRKFFEPRYISEISPTDFATPKRAKRTLDLIEKTDRRKTEKIKQLQRQTRDLQQKVGSLQDSINHLKENRMLTDESGDALMYDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HIX3</accession>
    <name>A0A8J2HIX3_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Resistance to inhibitors of cholinesterase protein 3 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HICCMSTLAB_LOCUS9844</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ric-3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5100771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HIX3"/>
    <dbReference type="OrthoDB" id="10070774at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043025">
        <property type="term" value="C:neuronal cell body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034394">
        <property type="term" value="P:protein localization to cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007271">
        <property type="term" value="P:synaptic transmission, cholinergic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026160">
        <property type="entry name" value="Ric3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032763">
        <property type="entry name" value="RIC3_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21723:SF3">
        <property type="entry name" value="PROTEIN RIC-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21723">
        <property type="entry name" value="RESISTANCE TO INHIBITORS OF CHOLINESTERASE PROTEIN 3 RIC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15361">
        <property type="entry name" value="RIC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="33"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="256"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="Resistance to inhibitors of cholinesterase protein 3 N-terminal" evidence="8">
        <location>
            <begin position="209"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF15361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAG5100771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="461" mass="52095" checksum="50A20FD2FB63454E" modified="2022-05-25" version="1">MIMDKTRHYQRIANDTVQNKMSGESDFGPRKTLIVLTVVAGCFAILWPKIFYPMLIGPGNTPHSPIDGSVCCDLIFETDVNAVDILQEMCKNILNHHQVDPRVRDIVNINKLSPQSINFCREQVLSRCGIDLSSFLAEEEKLGKTYKQVLEEIRSFNSSLCLKINFGVSLSRLGTPHLIRYHILMPHTPIKQERRLPPHAGGLHPAMRERGRAIPSSHIVPRVEGRPEQVFSHKMRPPMGGPGRVITPQGGSGSSMGIIMPLYTVGILLFFLYTITKVLRKNPNNDIYREYSNPEAEKEFRDRVFNPEILTSAITGVPHYRKEKSPELIKRTPTIDELKQQAAGDIEVDQLIQRLADTEAAMERIVVQMGNLSRTVAQNPTSQQDTQVYQTHFENHFEREKSPPKPIYLEGALPSQCELLVTDSKTQAENFEENNEVPVVLSGKMTLSLISLDQIPPVRKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HJB3</accession>
    <name>A0A8J2HJB3_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Similar to ENTPD5: Ectonucleoside triphosphate diphosphohydrolase 5 (Ailuropoda melanoleuca)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HICCMSTLAB_LOCUS8949</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GDA1/CD39 NTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5097931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HJB3"/>
    <dbReference type="OrthoDB" id="6372431at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd24046">
        <property type="entry name" value="ASKHA_NBD_NTPDase5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.150">
        <property type="entry name" value="Exopolyphosphatase. Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000407">
        <property type="entry name" value="GDA1_CD39_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11782">
        <property type="entry name" value="ADENOSINE/GUANOSINE DIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11782:SF127">
        <property type="entry name" value="NTPASE, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01150">
        <property type="entry name" value="GDA1_CD39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="36"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="201"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="232"/>
            <end position="236"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR600407-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR600407-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAG5097931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="476" mass="53224" checksum="BDFF5629A63891F8" modified="2022-05-25" version="1">MELRRRQLSNGDTKDVPPRQKKAVPSFFLKIRPKKVIITLSILFFFYIALSFNSEPLRFGSSMIDRLASSLNLHKQQYVVIIDAGSTGSRVLAFTFHNSILNNDLVLDSELFAEVKPGLSSFADDPQAGVETLRTLLDKAKAVIPESAWAHTPVSMKATAGLRLLPRAKADNIIQECRKFFSQSGFFTTKNSVSIMEGVDEGIFAWFTVNFLTGKLSSYKNDNTAAVLDLGGGSTQVTYALDEEDLKVLDKHFYTINAFNRNMTLYTYSYLGMGLMAARKGVLTGFGHHQEDKDQAPKVQEVLVRSECVNPIVSAKWNYAGVNYLVKGPVNGTHKKVKGWNGAVTEEDRPVVRVNECIKVVKNYIDTIDEKPVGLAKHNIYAVSYYYDRATEAGLIDPFTGGVITLQSFHKKLVEICNYPNTDQPFMCLDMTFIYVLLHDAFGLDHTTKLNLYKKYNGHELSWSLGAAFSLLDSDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HJG8</accession>
    <name>A0A8J2HJG8_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ubiquitin carboxyl-terminal hydrolase 7</fullName>
            <ecNumber evidence="4">3.4.19.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Ubiquitin thioesterase 7</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Ubiquitin-specific-processing protease 7</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">HICCMSTLAB_LOCUS10040</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase C19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="4"/>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5100967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="289038at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00121">
        <property type="entry name" value="MATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03772">
        <property type="entry name" value="MATH_HAUSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02659">
        <property type="entry name" value="peptidase_C19C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.210.10:FF:000006">
        <property type="entry name" value="Ubiquitin carboxyl-terminal hydrolase 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.10:FF:000005">
        <property type="entry name" value="Ubiquitin carboxyl-terminal hydrolase 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.210.10">
        <property type="entry name" value="Apoptosis, Tumor Necrosis Factor Receptor Associated Protein 2, Chain A"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002083">
        <property type="entry name" value="MATH/TRAF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008974">
        <property type="entry name" value="TRAF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47022">
        <property type="entry name" value="BTB AND MATH DOMAIN-CONTAINING PROTEIN 36-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47022:SF1">
        <property type="entry name" value="BTB AND MATH DOMAIN-CONTAINING PROTEIN 36-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00917">
        <property type="entry name" value="MATH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22486">
        <property type="entry name" value="MATH_2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00061">
        <property type="entry name" value="MATH"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49599">
        <property type="entry name" value="TRAF domain-like"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50144">
        <property type="entry name" value="MATH"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8 17" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="7" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="MATH" evidence="15">
        <location>
            <begin position="13"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="MATH" evidence="15">
        <location>
            <begin position="154"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="MATH" evidence="15">
        <location>
            <begin position="296"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="domain" description="MATH" evidence="15">
        <location>
            <begin position="513"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="domain" description="MATH" evidence="15">
        <location>
            <begin position="655"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="domain" description="MATH" evidence="15">
        <location>
            <begin position="773"/>
            <end position="899"/>
        </location>
    </feature>
    <feature type="domain" description="MATH" evidence="15">
        <location>
            <begin position="927"/>
            <end position="1056"/>
        </location>
    </feature>
    <feature type="domain" description="MATH" evidence="15">
        <location>
            <begin position="1112"/>
            <end position="1221"/>
        </location>
    </feature>
    <feature type="domain" description="MATH" evidence="15">
        <location>
            <begin position="1250"/>
            <end position="1379"/>
        </location>
    </feature>
    <feature type="domain" description="MATH" evidence="15">
        <location>
            <begin position="1444"/>
            <end position="1572"/>
        </location>
    </feature>
    <feature type="domain" description="MATH" evidence="15">
        <location>
            <begin position="1789"/>
            <end position="1918"/>
        </location>
    </feature>
    <feature type="domain" description="USP" evidence="16">
        <location>
            <begin position="1937"/>
            <end position="2245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1080"/>
            <end position="1102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1559"/>
            <end position="1625"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="2269"/>
            <end position="2309"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="1638"/>
            <end position="1665"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="1559"/>
            <end position="1569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="1570"/>
            <end position="1581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="1601"/>
            <end position="1610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="1612"/>
            <end position="1624"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="2269"/>
            <end position="2296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00021393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00031508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CAG5100967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="2317" mass="265829" checksum="B571E43BACC0BD4E" modified="2022-05-25" version="1">MDSENSQLTTVTESTFQLTVENVSELKTSVLSSPVICQHLPWNIVVKPNFETGIGKQPLGFFITCDGNSSKDWMCQAAVEFSLYHSKKTRKPFTRKFSHVFCVERNTVGIENFLLWEEVIDDANGYVKDDSLTFEVCVMPELPDDKKADFSVTEVVFRHTLKNVLNINKPVQLGPFTACDFAWKINVKLPSKKLLEKPHSLGLHLQCNREVFSNSWTCRARIEVCLLSRKKIPEKLYRILQHQFSSRNNTVGVEDLISWKDLLNEDKGYIINDSIIVEVHVVPAKFDLKAYLNVTEATFWYTFESVSKINVSRLSPPCFIGNFPWRIKILPNKLKDGLANSLFGCYIYCNEGNKSKSWGCNAIGELRLVSNQKSRQAFARKLLPHHFDGQHNNWGFDCFMLWKDVINPIKPKSSMVLKEATIEYTVQNFSQLKDAVSSPTCTIQHLPWNVLVKPFYETDLGKLPFGLFVICDGNDSTNWTCRADVEFNIYPLNKKFRVPYFRIKPELSMVLKEATIEYTVQNISKLKDSISSPTCTIQHLPWNVLVKPSYETDIGKRPFGLSVTCDGNDSTNWTCRADVEFNIYSFNKKCRVPFSRRRKHTFSTKANTTGFEVLWEKITTSEKRLIENDSIILEVCIHCHPENSEETNADCSVVETVFRHTIKNISKIQKPFILGPFPALNLSWKIIAYFPTKPTEPQSLGLHLQCNKDVHSDTWNCDARIEFRLLNHQKSDEKLCRIIQHQFSGKENTAGVDDFIQLKDLLNVAKACLSVREGTFWFKFENVSKITGDQLSSPCTIGNFSWKIVIKPFKKADEELYLACYLRYGQVNSSTSSSCDAIATMKLVSFEKDKQSHKQKTPPKHFTKEIDSWGFSRFILWKDLMDSEKGFVKNDSMTIKIKDLSVVPNRRQFFDLSDEMDGAEIIFSVTEGTLRYTVKNISKMKTPQYSSVWVIRNLLWKIMVHPVSSGGLKNQSTESLGFFLQCDTKDLSNSWGCDAVVELRLLSNKEGEKPFTRRIQHFYYSLESDWGFTHFIPWKDLLDPENGYIQDNSITVEAHVVTGEPIEIDLEKLKLLEDSVTQRRESLSTSDGDSSNRKDDSDSSIDTIKPVKKKSIGKLRYTVKNLARLKKCEYSPPFNINNLSWHIVVKPNIRSEEKNQQEKYVGVYVKCDGPENSSPWLVYASVYMRVIPVKEDVDAFDEDFLLNPENGFITENGSVTFESHMFLDKCQGITLDSRRFFSEVDPNECNAESEVVYKFKVDHISTLEESRLSPTFKLHGLSWSIIISPEVIYRHCDEPIETLGFFLRCQGLPLLKNWCCYAAAELRLLSNKPDQQPFLRRIYHIFNNVKKTWGFKEFLPWKQVLAPENGYTVNDSITAEIHVLAEPPYISKMKRYNNKLPLKLLNVIDEDESSIPTPGRQEEKLIINNLFSFTCNDPKNKSDEQMPEVDFQFIVQNVSQLSEVLYSPQIVVSNLLWRMKIVPRIRESILQAEMLAFFLECGPITETSKPWCCYANATLRLLSCQKDKPNLSTKIQHLFNPKDASSGCIEFIRWDDLLDHENGGSHGDNNESKKHLKSWQKKGKKNTYAPYNRNSIVGPWRRANSRYQTSSCGKATSPTGRRSSSSSGDTIDEANVVVLDYHQHHQDNLQELQQEVTETEQLSPKLTQEKSSATLESAVLQPEINTIPEVTSTAPVVREVQSSDKTTINIGVAMNHVNDQDNTKQQKFKRALVIDNFDDLMDTQEETPNDGGGDGNDLRPINGELEFELAAVDEMSSCIGLDQEMDEDEARSEATFRYTVENVSKMKESQLSPPCIVRNLPWKIMVMPRSSQTQERQPQRSLGFFLQCNGESESTTWSCYAVAELRLLSCKEGQEPFSRKIQHLFYTKENDWGFSHFMLWQDVLDPDKGYIKDDSITLEVHVVADAPHGVSWDSKKHTGYVGLKNQGATCYMNSLLQTLYFTNQLRKAVYKMPTESDDSSKSVALALQRVFHELQFSDKPVGTKKLTKSFGWETLDSFMQHDVQEFLRVLLDKLESKMKGTCVEGTVPKLFEGKMASFIKCKNINYTSTRVETFYDIQLNIKGKKNIYESFRDYVSTEILDGDNKYDAGDHGLQEAEKGVVFQSFPPVLHLHLMRFQYDPVTDCSVKFNDRFEFYDKISLGEYLQAEESTNANYTLHAVLVHSGDNHGGHYVVFINPAGDGKWCKFDDDVVSRCTKQEAIEHNYGGQDEDMSMAVKHCTNAYMLVYIRNSELENVLQEVKEEDIPQEVRNDFQREHSQEMYDHKRDKDMTDSIRDNRDTDIATLRPCTQNPRNPNLYIHDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HK80</accession>
    <name>A0A8J2HK80_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS9719</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5100646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HK80"/>
    <dbReference type="OrthoDB" id="7697930at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="150"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="150"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="184"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="210"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5100646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="220" mass="24900" checksum="D39E3FBA8A5C42B9" modified="2022-05-25" version="1">MNTSVSLRNPMFLLGEPTETISGNKLPTNKQVLQLLFYQKREAKKILTASYQFVIGEVTKFWFRAGIKIQIVPRCKLTKNPNPTVEREFSEFLETLFDIAHGNVQDIADSEALKFLFDQITDRKYHLRVCKEIGNTRQLLEKQIFEQDHTNTTQTSDENISGNDNNVNLITDDEYRSNSDVALPSSSKSTSEPPLSGEQALSGETTTTTSHQSTLSMFEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HKG6</accession>
    <name>A0A8J2HKG6_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Odorant receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">HICCMSTLAB_LOCUS12012</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Odorant receptor which mediates acceptance or avoidance behavior, depending on its substrates. The odorant receptor repertoire encodes a large collection of odor stimuli that vary widely in identity, intensity, and duration. May form a complex with Orco to form odorant-sensing units, providing sensitive and prolonged odorant signaling and calcium permeability.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Interacts with Orco. Complexes exist early in the endomembrane system in olfactory sensory neurons (OSNs), coupling these complexes to the conserved ciliary trafficking pathway.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Cell membrane</location>
            <topology evidence="12">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the insect chemoreceptor superfamily. Heteromeric odorant receptor channel (TC 1.A.69) family. Or2a subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5104458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HKG6"/>
    <dbReference type="OrthoDB" id="6597368at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005549">
        <property type="term" value="F:odorant binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004984">
        <property type="term" value="F:olfactory receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004117">
        <property type="entry name" value="7tm6_olfct_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21137">
        <property type="entry name" value="ODORANT RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21137:SF37">
        <property type="entry name" value="ODORANT RECEPTOR 46A, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02949">
        <property type="entry name" value="7tm_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 12" id="KW-0552">Olfaction</keyword>
    <keyword evidence="7 12 14" id="KW-0675">Receptor</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 12" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="13" id="KW-0732">Signal</keyword>
    <keyword evidence="8 12" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035184081" description="Odorant receptor" evidence="13">
        <location>
            <begin position="19"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="28"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="63"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="124"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="167"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="257"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="290"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00037764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00037946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00038679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU351113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CAG5104458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="382" mass="43834" checksum="20469778726F7B90" modified="2022-05-25" version="1">MLLHWSFGILQCLGLWQAANSINSTWKIFFYFIYTNFMIIFIYSCVLFELIALIGSFDNPELFINNLIVLLTMVGVCGKIANVIVKQKEIDQLIEILESYPCCYQNEKEKVIEKIFDKTIKSRTIAYLIMTESAVVMVVSVSILCDTPNRALPFDIWLPYNYKTSNIGYWIAYSHQIFAHIFGALINVAYDTMIPGFMLKICAQLSILEHRVGLLLTKNDNLSKSLDAKKQKEMNQISKCVQHHLKIFQLSEITNKVFSTVTFLQFSISSIVICVTVYRLSQITIDNPEFAPTAFYFTCMLTQIFFICFASTECNLKSSEVAAAIYQSDWYNLNVDNQKSLLLIMMRSQKTLKFTAGHFVDVSLNSYNQLVKLSYSAYNVLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HKN2</accession>
    <name>A0A8J2HKN2_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 14">Pyrroline-5-carboxylate reductase</fullName>
            <ecNumber evidence="4 14">1.5.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">HICCMSTLAB_LOCUS12164</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-proline + NAD(+) = (S)-1-pyrroline-5-carboxylate + NADH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:14105"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17388"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="EC" id="1.5.1.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 14">
            <text>L-proline + NADP(+) = (S)-1-pyrroline-5-carboxylate + NADPH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:14109"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17388"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="EC" id="1.5.1.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 14">Amino-acid biosynthesis; L-proline biosynthesis; L-proline from L-glutamate 5-semialdehyde: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the pyrroline-5-carboxylate reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.2" evidence="4 14"/>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5106246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HKN2"/>
    <dbReference type="OrthoDB" id="10263291at2759"/>
    <dbReference type="UniPathway" id="UPA00098">
        <property type="reaction ID" value="UER00361"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004735">
        <property type="term" value="F:pyrroline-5-carboxylate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055129">
        <property type="term" value="P:L-proline biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3730.10:FF:000001">
        <property type="entry name" value="Pyrroline-5-carboxylate reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000190">
        <property type="entry name" value="Pyrroline-5-carboxylate reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3730.10">
        <property type="entry name" value="ProC C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01925">
        <property type="entry name" value="P5C_reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028939">
        <property type="entry name" value="P5C_Rdtase_cat_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053790">
        <property type="entry name" value="P5CR-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029036">
        <property type="entry name" value="P5CR_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000304">
        <property type="entry name" value="Pyrroline-COOH_reductase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00112">
        <property type="entry name" value="proC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11645">
        <property type="entry name" value="PYRROLINE-5-CARBOXYLATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11645:SF62">
        <property type="entry name" value="PYRROLINE-5-CARBOXYLATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03807">
        <property type="entry name" value="F420_oxidored"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14748">
        <property type="entry name" value="P5CR_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000193">
        <property type="entry name" value="Pyrrol-5-carb_rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00521">
        <property type="entry name" value="P5CR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 14" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 13 14" id="KW-0521">NADP</keyword>
    <keyword evidence="10 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8 14" id="KW-0641">Proline biosynthesis</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyrroline-5-carboxylate reductase catalytic N-terminal" evidence="15">
        <location>
            <begin position="47"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="Pyrroline-5-carboxylate reductase dimerisation" evidence="16">
        <location>
            <begin position="204"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>NADPH</name>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00021413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00050547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00052690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR000193-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU003903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF03807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF14748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CAG5106246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="317" mass="34219" checksum="DCA678AAD7B1F41E" modified="2022-05-25" version="1">MTKLTKAYCSVYFIYDSGSPLFYSKNISDKFQNIYLFFFFCNKQTMKIGFFGGGKMAHALAKGFIKAGLKGDSMVASCLPNDLKSKHAFETIGSKVVFLNKLVADHGDVLIISVKPQVVSKILPEIKNSDKLILSIAAGTSIDDLEKNLPKGTPVIRLMPNIPVSIGYGATVFKRGTFADQEHAVLVKKLFTSMGICEEIDEDESLLDTVTALAGSGPAYVYMMIESLADGAVKMGMSRQLAYKLATQTVLGAGAMVNHHQSIGDGCHPAQLKDDVASPAGSTIMAIHHLEKYGMRSAVIGAIEVATLACRTFSKKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HLB4</accession>
    <name>A0A8J2HLB4_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">protein-tyrosine-phosphatase</fullName>
            <ecNumber evidence="1">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HICCMSTLAB_LOCUS10552</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="1"/>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5101650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5794147at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030054">
        <property type="term" value="C:cell junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009653">
        <property type="term" value="P:anatomical structure morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048666">
        <property type="term" value="P:neuron development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00047">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000242">
        <property type="entry name" value="PTP_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008356">
        <property type="entry name" value="Tyr_Pase_KIM-con"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46198">
        <property type="entry name" value="PROTEIN-TYROSINE-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46198:SF4">
        <property type="entry name" value="PROTEIN-TYROSINE-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00102">
        <property type="entry name" value="Y_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00700">
        <property type="entry name" value="PRTYPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00194">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50055">
        <property type="entry name" value="TYR_PHOSPHATASE_PTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035295303" description="protein-tyrosine-phosphatase" evidence="8">
        <location>
            <begin position="21"/>
            <end position="1400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="1064"/>
            <end position="1087"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="9">
        <location>
            <begin position="1155"/>
            <end position="1388"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="10">
        <location>
            <begin position="1302"/>
            <end position="1379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="23"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="77"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="258"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="654"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="280"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="299"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="335"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="664"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="691"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="active site" description="Phosphocysteine intermediate" evidence="5">
        <location>
            <position position="1329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR608356-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAG5101650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="1400" mass="153553" checksum="F64C78F1F02BCEC6" modified="2022-05-25" version="1">MHDRELTSILLLLSATKSQSETTVSIAPEGTRATTTKDYKSSSPGNSTTILRKTLADQEVDVLAHLPALKNDRERETPFYSKLTTEPSLDPRDTQLSQRKLNYKEKHSALTSNNHDTNISSNKTTKLLKIDLLKTEKASSSDNQSKKHFFEQLIAPNGHKIVDLNGHELAEFNLEGNESEEGDFDESESREATTPKIGVISLANDTQVNFKGHKKEIHEDAVLIKGHKLIKNPVEKLKTFDKFDQIEGLNASAALGSNIGEPERIQEQKLPSELIEPEIGDNKTEKVESNGKSEHFGENENEEGENDNEESLEKSEDLGEEEKDTEGKVNGNGDGLERIVEEKEPNSNEKDLTPKARTISFGGGNRFSSTEEKATGFAKENGDVNLTKDFKPYPYFKTPTVVVNLNASENIDVNVNAIEKKKSGVFNKETDEIYTYENTINKSKDEKNYLVTESSVVIDNSIQTKRVNLKRSSNATKLLTDSSILSPSSSSLSSVTVKSIAEPVNNTHVDVDVSDNDKLNLNLNLNLSDNLKIKDNVNDIPRNPGEVVERKGTVDLASNGLTGENIEKNSTDRELVTSERPIIEANINQSSVETQLTDEILRVNITELNETATMSPTTTLTTLTTTTTITTTPIMTSTTTTSYEKPVETMNLNSSSIKPPGVQLISTSPAATSSDVDEEEVTTSGVTANKLEITSSPITEETTLSPENMTSPENFSKTLTFNSTVSSIDFPEITTAAVEYEFVGLNESTSAPFDTTSGDADGDRNVSTTLAPKLSSVSSESPDEEITTIETVTGNELLTTTETNNNLTDTTASYITTAKDAADETTISSEVEATTVEVTKEINGNETNDLSSTESIPITEVISSSGASSSSIVTTNSVETTADELNTIPSVTPTFNPLNVTSSTESNIDKMTSKIESSTVATSVEDDVTESTVRVVTEDDVQRFTPGDVTLLVRIVVEGTWTDICPHLPALKQSLANLLATGMDKNVSASQIIFQKNPCDEVVGKNMGMELILSTIILYVIDENGNFDAAMTQNLPNLYSQAPFESRLTIRSFQLVQDGDSGNAIAVIVVSCVAFVCLVLLASLLFIMRKRQTRFNYGERCRPVSLDAYSLDSVSAYNSVRRKGARASKRSYGNPTFEDSVSARIDELPPGAEVKNRYANVVPLPETRVSLMKSNNDPLSEYINASYVRGPKNATKYYIACQAPMESTVTDFWRMIWEQQSKVIIMLTDLIENGVEKCSEYIPPSEVTDCHRLYGDYQVTLKKRETKEKYAISTIHLKNLENNTYREVFHIWYLWPANGVQTDAAGLIAILLEARALQRGGPGPIVVHCSPGTGRTGTLIALDLGIRQYEITRTVDVPRVVYTIRRDRAGAVQTKEQYAFIYKALNLYATKLAGGGLEST</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HLL8</accession>
    <name>A0A8J2HLL8_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Similar to Nep2: Neprilysin-2 (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HICCMSTLAB_LOCUS10760</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase M13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5101928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HLL8"/>
    <dbReference type="OrthoDB" id="6475849at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08662">
        <property type="entry name" value="M13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1380.10">
        <property type="entry name" value="Neutral endopeptidase , domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000718">
        <property type="entry name" value="Peptidase_M13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018497">
        <property type="entry name" value="Peptidase_M13_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042089">
        <property type="entry name" value="Peptidase_M13_dom_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008753">
        <property type="entry name" value="Peptidase_M13_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733:SF224">
        <property type="entry name" value="NEPRILYSIN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733">
        <property type="entry name" value="ZINC METALLOPROTEASE FAMILY M13 NEPRILYSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01431">
        <property type="entry name" value="Peptidase_M13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05649">
        <property type="entry name" value="Peptidase_M13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51885">
        <property type="entry name" value="NEPRILYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035253478" evidence="9">
        <location>
            <begin position="24"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M13 N-terminal" evidence="11">
        <location>
            <begin position="53"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M13 C-terminal" evidence="10">
        <location>
            <begin position="510"/>
            <end position="710"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF05649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAG5101928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="713" mass="83233" checksum="CD31E495370C7382" modified="2022-05-25" version="1">MMISSMITITIVSTIALLSPIEANNDRTSTESQAKNDKLELTILRNLNTSVNPCENFYQFSCGNFNNASANTQYSDHNDFFKPMRDRENKIKQMLLNDDYLYSLEPFNRLKKFINSCKRLEVNIDAKIDSADVNRNRSLNFMTEVITKLGGWPILEGDKWNDTKFNWLEFTEISRIIGTEGYFFLKPSVQMFNHTAMLSISPPGLEFSNKHLVENQKSEKVRAYFNYMLNVAEFLRIDSNISNIDITDALAFELDLIFGTSGNTESSITEMTIKEMNEEWPNIDWIKLFRSFLGSEYSIKEDWKILVQNSNYIKNFNQLIQLTSKRVQANYAVWKTIKRLISFTESSRLFSLQESYYRIRSPSQTISGYDCINFLVNLLPELALSYYERHYPIDARFLSNIENIIIDIKKNFAVVLNNHEWLDETTKNKLVLNLDSTKFVLGLTETMRNNERLSAYFDNLVIDEFIFLKNLLAINAFNHQKLIDHVFTSKNMIDPTSVFRRINPFKYINNAFYDDITHTVFIDSEAMRNLFFDIDRPNFTKYSIIGFTISHELAHTIENIHDVFDKEGNIVNGWSLRSNNNYKHVKRCLIDQHLNNTKNSKEDMVLSYLQENIADNIGLTIAYLAYKNWVQKYGDSSTYSKLNYTQNQLFWLSLANKWCVPEEIDGYAYLKTNHTSLDFRLLGLLSNNDYFAKDFNCPLGSPMNPEEKCHFFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HMA1</accession>
    <name>A0A8J2HMA1_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to Dgk: Diacylglycerol kinase 1 (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS11246</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5102912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HMA1"/>
    <dbReference type="OrthoDB" id="242257at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000017">
        <property type="entry name" value="Diacylglycerol kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046349">
        <property type="entry name" value="C1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57889">
        <property type="entry name" value="Cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="EF-hand" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="2">
        <location>
            <begin position="38"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5102912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="132" mass="15033" checksum="A4B0AB90FBBC9787" modified="2022-05-25" version="1">MFRLYDTDGNGVLDTNEMDCIVNQMMNVAEYLGWDVSELKPILQDMMIEIDYDADGTVSLEEWKRGGLTTIPLLVLLGLDSHVKEDGNHLWRLKHFNKPAYCNLCLNMLVGLGKKGLCCVCKLKNHLIIFLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HN87</accession>
    <name>A0A8J2HN87_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Similar to CG3556: Uncharacterized protein CG3556 (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HICCMSTLAB_LOCUS11956</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5104346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HN87"/>
    <dbReference type="OrthoDB" id="6343110at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031419">
        <property type="term" value="F:cobalamin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015889">
        <property type="term" value="P:cobalamin transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.130.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002157">
        <property type="entry name" value="Cbl-bd_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051588">
        <property type="entry name" value="Cobalamin_Transport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008930">
        <property type="entry name" value="Terpenoid_cyclase/PrenylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10559:SF18">
        <property type="entry name" value="TRANSCOBALAMIN II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10559">
        <property type="entry name" value="TRANSCOBALAMIN-1/GASTRIC INTRINSIC FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01122">
        <property type="entry name" value="Cobalamin_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48239">
        <property type="entry name" value="Terpenoid cyclases/Protein prenyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0170">Cobalt</keyword>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3 7" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035298291" evidence="7">
        <location>
            <begin position="25"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="440"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="187"/>
        </location>
        <ligand>
            <name>cyanocob(III)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:17439"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="231"/>
        </location>
        <ligand>
            <name>cyanocob(III)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:17439"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="281"/>
        </location>
        <ligand>
            <name>cyanocob(III)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:17439"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="404"/>
            <end position="405"/>
        </location>
        <ligand>
            <name>cyanocob(III)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:17439"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="421"/>
            <end position="423"/>
        </location>
        <ligand>
            <name>cyanocob(III)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:17439"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="160"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR602157-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR602157-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG5104346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="459" mass="51553" checksum="95CAECB67D22F806" modified="2022-05-25" version="1">MWRRASMGAVVLIVLASVFACCQGSNVESRPTEAEVESMVSRATMWLWYQRDQDAGWFNNTHWVLLALRLANLSRTDNNPLSVSVELQLSNKQLELEIVILLWRHREVGFSETSLARYTLALNALCMDPRQFHGHDLIGTLQHHAPPVDYDFALTTLAACSAQAHIRKRQIGRLLDITNAVQYHNIDTIAMVVLALRCIIQDHRHRNLGHFVRKPAMSLTKRQRLDGSFGDLRTTALAMQALKQVENEPADNWNRSAALSWLMSRQQPDGSFDQDVYLTAQVILGIIPKSLINIRSLNCLLSNNTLPGLVPNNNFNDNFISSSTAVNAETNTSAYESTGSKVSTQTTPHQLVNISYTLWVGTNETYHLTVTAPKNETFYGVMLLAAEMSPHFQFSASEWPNGHYVHTLAGYKEEPMSYHYWLLYRLTSPPDLSSPPGNQLVAPGGITLIIIIYYTILST</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HNB1</accession>
    <name>A0A8J2HNB1_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="16">CYP6AQ21</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">HICCMSTLAB_LOCUS12016</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Microsome membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5104466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HNB1"/>
    <dbReference type="OrthoDB" id="2789670at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11056">
        <property type="entry name" value="CYP6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000042">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050476">
        <property type="entry name" value="Insect_CytP450_Detox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24292">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24292:SF45">
        <property type="entry name" value="CYTOCHROME P450 6G1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 13 14" id="KW-0349">Heme</keyword>
    <keyword evidence="10 13 14" id="KW-0408">Iron</keyword>
    <keyword evidence="12 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 13 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0492">Microsome</keyword>
    <keyword evidence="11 14" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="9 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="13">
        <location>
            <position position="456"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="non-terminal residue" evidence="16">
        <location>
            <position position="513"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CAG5104466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="513" mass="58512" checksum="4B6E29188CF19BD9" modified="2022-05-25" version="1" fragment="single">MAVITRYLVLDFLVLICGLIVLSYLYMTRKFKYWKKHGVTEITPTPFVGNFGDCLMTKKSSGQWLRDIHEWSSGLPYMGFYIFDRPCLLIRDPELVKNILVKDFNTFPDRFVSASPHDRIGDANLFLIKNPAWKVVRTKLTPLYTSGKLKRMFELMVDVGEDLMTHMKSLKLEGQGQNVEVKDLSAKFTTDMIATTAFGVRANCLNDPNAAFREAGRRVFATSLYRNFELTSLFFAPQLAKPLGLKFIPSNASKFLRDTLWGVILERERSNYKRGDLIDLLVELRKANAESSTRDIFDFDGDNLVAQAVVFYTGGFETSSSALSFTLYEIAIQPEIQTRLRQEILDGLEQSDGKVTYDLVQLFYYPYLDMVVAETLRKYPPLPFLDRLTKENYKLPNSDLVVEKGTPVFISMTGLHYDPEYFPDPNKYDPERFSEANKKSRKQGVYIPFGDGPHICIGLRIGLLQTKLGLIKLLPKYEFSPSKETMIPMRLSPKATITTADGGVFLNVKEIAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HNJ8</accession>
    <name>A0A8J2HNJ8_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Odorant receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HICCMSTLAB_LOCUS12243</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Cell membrane</location>
            <topology evidence="1 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the insect chemoreceptor superfamily. Heteromeric odorant receptor channel (TC 1.A.69) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5106404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HNJ8"/>
    <dbReference type="OrthoDB" id="6614360at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005549">
        <property type="term" value="F:odorant binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004984">
        <property type="term" value="F:olfactory receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004117">
        <property type="entry name" value="7tm6_olfct_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21137">
        <property type="entry name" value="ODORANT RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21137:SF35">
        <property type="entry name" value="ODORANT RECEPTOR 19A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02949">
        <property type="entry name" value="7tm_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 10" id="KW-0552">Olfaction</keyword>
    <keyword evidence="8 10 11" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="9 10" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="22"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="175"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU351113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAG5106404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="398" mass="45421" checksum="71DF28A92F559F9C" modified="2022-05-25" version="1">MDFFHQPCYKLSRNFARLIGRWPYQSSLQCFMIGVVIIAAYILQVGPKILADIVHSDDQELVLETLAPTITNIMAFAKYINTWVNAKMLKKLFETIKDDWELVTNSEEKEILKSYAEFGKLLATGYAGFVYITTITFVTEPVLPILINSVFKTNLSAPHKFADPMEWIIIDKEKYYWILLSNSSVCIMVILSCLISYDVIFITFVHHACGLFALTGHRIQNLTSDKNLKMLPRRTTILNRSHDFHYKHLISCIKIHKLALNYVDLIETTFSGCFGMVVGLNLPLMSITGVQIIAQGGTLQQKIKYVMFTGAQMLHLFFECFLSQRLTDMSFQIQEHIANGKWYNLSPKSQKLLILMTMRSQVPCILTAGKIMGLSIKSFGMMLKTSGSYFTMLLSFQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HP52</accession>
    <name>A0A8J2HP52_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Adenosine 3'-phospho 5'-phosphosulfate transporter 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">PAPS transporter 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Solute carrier family 35 member B3 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HICCMSTLAB_LOCUS10124</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nucleotide-sugar transporter family. SLC35B subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5101051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HP52"/>
    <dbReference type="OrthoDB" id="438495at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046964">
        <property type="term" value="F:3'-phosphoadenosine 5'-phosphosulfate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013657">
        <property type="entry name" value="SCL35B1-4/HUT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10778:SF8">
        <property type="entry name" value="ADENOSINE 3'-PHOSPHO 5'-PHOSPHOSULFATE TRANSPORTER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10778">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35 MEMBER B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08449">
        <property type="entry name" value="UAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="34"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="64"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="95"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="125"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="149"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="174"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="214"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="251"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="277"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="304"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00039669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00041866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00042729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAG5101051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="357" mass="40462" checksum="23B25829ADB6FBE6" modified="2022-05-25" version="1">MGMDYNKLHPDDDREGAVKLLCFDMTKASEKSRFVWCSIGVFFFYIIYGYLQELIFSLEGFREYGWYLTLIQFAYYTVFGILESKLRGVTRRIPLSTYIILAFLTLGTMGFSNSSLGYLNYPTQVIFKSCKLIPVLIGGIIIQGKQYGLLDFVAAGFLCAGLVLFTLADSMISPRFSIIGVMMISSALLCDAIIGNVQEKAMRQYKATNTEIVLYSYSIGFLYLFIILFTTGQLTKGVTFCADYPIETYGYAFLFSISGYLGIQMVLTLVQTSGAFVAATVTTCRKAVTITLSFIFFYKPFTMQYLWSGLLVLLGLYLNIRSKQRGGNKVSLKTIWSYIQHCWSKHNQIQRQLMMNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HPG7</accession>
    <name>A0A8J2HPG7_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Similar to Eif2d: Eukaryotic translation initiation factor 2D (Rattus norvegicus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HICCMSTLAB_LOCUS10425</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5101352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HPG7"/>
    <dbReference type="OrthoDB" id="199771at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001731">
        <property type="term" value="P:formation of translation preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11608">
        <property type="entry name" value="eIF2D_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11610">
        <property type="entry name" value="eIF2D_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21156">
        <property type="entry name" value="PUA_eIF2d-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.400.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039757">
        <property type="entry name" value="EIF2D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048247">
        <property type="entry name" value="eIF2D_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039759">
        <property type="entry name" value="eIF2D_SUI1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041366">
        <property type="entry name" value="Pre-PUA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048248">
        <property type="entry name" value="PUA_eIF2d-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001950">
        <property type="entry name" value="SUI1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036877">
        <property type="entry name" value="SUI1_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058886">
        <property type="entry name" value="SWIB_eIF2D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036885">
        <property type="entry name" value="SWIB_MDM2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004521">
        <property type="entry name" value="Uncharacterised_CHP00451"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057429">
        <property type="entry name" value="WH_eIF2D"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00451">
        <property type="entry name" value="unchar_dom_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12217">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12217:SF4">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17832">
        <property type="entry name" value="Pre-PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26292">
        <property type="entry name" value="PUA_elF2D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01253">
        <property type="entry name" value="SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26291">
        <property type="entry name" value="SWIB_eIF2D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25304">
        <property type="entry name" value="WHD_eIF2D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55159">
        <property type="entry name" value="eIF1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47592">
        <property type="entry name" value="SWIB/MDM2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50890">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50296">
        <property type="entry name" value="SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SUI1" evidence="3">
        <location>
            <begin position="482"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="192"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG5101352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="589" mass="64633" checksum="2B95DC95FF7EFE05" modified="2022-05-25" version="1">MFLKPIKVKSNNQLKGTERKKLCEDVLSAFPSLTDSQVQNLLPKKEAISFMKAVTHSGEICKLYCVAKIPMFFQLDQSQSTVPLFPTIFSLWQYPNLLYTFKTHNGVIPKLASGAGLMLPGVILDGPPTFHSYGKLLRNTPVAVITEDNMAAVAVGVTSHSSEDMYMSGGRGKCVDIIHVIGDMLCQLGKPPARPQIDPSFDNEKVDEPADQEPNGELTQVTDDKPESVDNAEQLINSINLEDNKNNSNEIEQENKEPIELIEDVDPIKEMDQLLEYCFLKACKRFKKTELPILSSSFFKNHLIAACPPDQVVDIKKSSYKKLSVFLAAMKTKGVIDTTILKGVESITYVKTEHPLLKELVINESSDCELNKSSNAPVVAECFKVTANVLPVVSKFGYEKGDIMKRLEIRKCFTEYVKKENLQDGKILNINPQLADILRTKENVLTLTMEDGINKFIGRMTHTHEITVAGTKLLHTGKLEPIDITVASRCNNKKVTLVNNLETFGIKLDEFSKECQGIGASATITDIPGKKTPSVLVQGNQVLYVYKLLTGNSCSSGSSGEIAGTATVGVDSSDAAAPDGSCHPLARCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HPM6</accession>
    <name>A0A8J2HPM6_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Similar to APN1: Aminopeptidase N (Plutella xylostella)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HICCMSTLAB_LOCUS11092</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5102592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HPM6"/>
    <dbReference type="OrthoDB" id="10031169at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042277">
        <property type="term" value="F:peptide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043171">
        <property type="term" value="P:peptide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.50.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="entry name" value="Neutral Protease Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1730">
        <property type="entry name" value="tricorn interacting facor f3 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045357">
        <property type="entry name" value="Aminopeptidase_N-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042097">
        <property type="entry name" value="Aminopeptidase_N-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024571">
        <property type="entry name" value="ERAP1-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050344">
        <property type="entry name" value="Peptidase_M1_aminopeptidases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014782">
        <property type="entry name" value="Peptidase_M1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11533:SF299">
        <property type="entry name" value="AMINOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11533">
        <property type="entry name" value="PROTEASE M1 ZINC METALLOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11838">
        <property type="entry name" value="ERAP1_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01433">
        <property type="entry name" value="Peptidase_M1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17900">
        <property type="entry name" value="Peptidase_M1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63737">
        <property type="entry name" value="Leukotriene A4 hydrolase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminopeptidase N-like N-terminal" evidence="4">
        <location>
            <begin position="24"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M1 membrane alanine aminopeptidase" evidence="2">
        <location>
            <begin position="254"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="domain" description="ERAP1-like C-terminal" evidence="3">
        <location>
            <begin position="458"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="domain" description="ERAP1-like C-terminal" evidence="3">
        <location>
            <begin position="773"/>
            <end position="926"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF11838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF17900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAG5102592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="931" mass="108515" checksum="9D7C30BA7C4B7255" modified="2022-05-25" version="1">MSEENCVLPFHLNLSDIVYEFDVKPRRYNLKLAPYYETNELTFDGEVSINFENVSEKSELKLHAKNLEILGNVILKKDDQTYDSSDYNIGIDNGDSVLTINFGQELPVGDYTLFIKFKSQPNYTSEVFEHASYTDNNDKREWILLSDFGTEGIQEMFPCWKEKSTASKFDVSIKHNKAHTVLFNSPVIESKVSEDDPDSVWTSFEELVAFNPHRLAFIIGNLELMSAHHNDPFRLWFPKNTIDCEKNDIKIIEKLWKALEIVTGITHKEHPFNKMDIVVLPEFIKSKSRNWGLCTINDVSIEFKENIDKTEKVETITNIAASMIDHWFGELIKSDHYATGSAISHGFRLYLTELVIDKIPSLKDEIMNAAGDKKEPIENILDSWCEFISVPTLAITRDYETNKAAVTEPRIFYGRKPHRYWFPLNWANEQDLDFEDTSVTQWFDGGVMKTEIPVTVPADRWIIVNKQHFDNYSKIHIFNRIQLINDAFAIADWGSLDYSVPFELAKYLSRETEFAPWTAFLHYIEQLYNESPLRVSPYFDNFKKYVLEVTDELEKRILLTDEANDDFTTRLLRISLVSVRCIFGSSGCGNYALTKLKNWLEDPNKYPISADMKDVILKSGICFADEDTWNKLWERYQLNLQSPENKKIDMDRMERWQTNKEENILNALSCTPSFELLKKFIIWVPEKVFADIIPRFWFKNIAMLNEKGVDAILDVLESKPTKENGEPLFSVYIVFEGCQAVKYLLKSKDQVEKWYDGDFMKTEIPVTVPAGQWIIVNKQHFGTYRVTYDEKNWKMIVEYMNSNNYSKIHIFNRIQLINDAFTIADWGLLDYSVPFELAKYLSCETEFAPWTAFLHYIEQLYNESPLRVSPYFDHFKKYVLEVTDELEKRILLTDEANDDFTTRLLRISLVSVRCIFGSSACGNYALIKLKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HPV0</accession>
    <name>A0A8J2HPV0_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Similar to PEDS1: Plasmanylethanolamine desaturase (Homo sapiens)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HICCMSTLAB_LOCUS13317</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the fatty acid desaturase CarF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5108598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HPV0"/>
    <dbReference type="OrthoDB" id="5103at2759"/>
    <dbReference type="UniPathway" id="UPA00199"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019547">
        <property type="entry name" value="Lipid_desat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052601">
        <property type="entry name" value="Plasmalogen_desaturase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48177:SF1">
        <property type="entry name" value="PLASMANYLETHANOLAMINE DESATURASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48177">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 189"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10520">
        <property type="entry name" value="Lipid_desat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Lipid desaturase" evidence="6">
        <location>
            <begin position="103"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007620"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF10520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAG5108598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="274" mass="32355" checksum="085C52213686E4A0" modified="2022-05-25" version="1">MTTMNTGVQHLEKAASTACTMANNFLAPVKTEQQIYENSMLEDDPNANSVVTTTKTLPDDRTTREFKFNSNSRVMWNCNSRLYLWISSLGSRHVGIGRVAYPWKSKPYQSIDTTTNFLRPFREHHIDPTSITRHDFIETNGDNFMVTIPALCKLTWDFLTLPEPEIQRRFLWSCYWWQLAIFVAMTNQIHKWSHTYFGLPGWVVWLQEHRVILPRRHHRVHHVAPHETYFCITTGWLNWPLEKLRFWPILETIIEGVTGYKPRADDFKWAQKRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HPV6</accession>
    <name>A0A8J2HPV6_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="20">Ultraviolet-sensitive (Apis mellifera)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">HICCMSTLAB_LOCUS13046</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 16">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5108055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HPV6"/>
    <dbReference type="OrthoDB" id="2105199at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009881">
        <property type="term" value="F:photoreceptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007602">
        <property type="term" value="P:phototransduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007601">
        <property type="term" value="P:visual perception"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15079">
        <property type="entry name" value="7tmA_photoreceptors_insect"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000044">
        <property type="entry name" value="Opsin, ultraviolet-sensitive"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050125">
        <property type="entry name" value="GPCR_opsins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001760">
        <property type="entry name" value="Opsin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24240">
        <property type="entry name" value="OPSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00577">
        <property type="entry name" value="OPSINRH3RH4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0157">Chromophore</keyword>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9 16" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0600">Photoreceptor protein</keyword>
    <keyword evidence="12 16" id="KW-0675">Receptor</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0681">Retinal protein</keyword>
    <keyword evidence="4" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="14 16" id="KW-0807">Transducer</keyword>
    <keyword evidence="5 16 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 18" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="15" id="KW-0844">Vision</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="47"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="86"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="115"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="162"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="210"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="275"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="311"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="19">
        <location>
            <begin position="65"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="350"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="353"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="CAG5108055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="369" mass="41335" checksum="90B8145B34B61F98" modified="2022-05-25" version="1">MSNDSIHWEARILPAGPPRLLGWNVPAEELVHIPEHWLVYPEPNPSLHYLLALLYILFTFIALLGNGLVLWIFCAAKPLRTPSNMFVVNLALCDFMMMLKTPIFIYNSFQTGFALGHLACQIFAFIGALSGIGASMTNAAIAYDRYRTIARPLDGKLSRGQAMLFIVLIWMYVIPWGLMPLMGVWGRFVPEGFLTSCTFDYLTDTSETRYFVATIFTFSYAIPMSLIIYHYCQIVSHVVNHEKTLREQAKKMNVESLRSNANANAESAEIRIAKAAITICFLFVASWTPYGVMSLIGAFGNKSLLTPGVTMIPACACKFVACLDPYVYAISHPRYRMELQKRLPWLEIRESTPDTTSTNTEAVNAPAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HQ72</accession>
    <name>A0A8J2HQ72_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Structural maintenance of chromosomes protein 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HICCMSTLAB_LOCUS13198</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SMC family. SMC5 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5108360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HQ72"/>
    <dbReference type="OrthoDB" id="10254973at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030915">
        <property type="term" value="C:Smc5-Smc6 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003395">
        <property type="entry name" value="RecF/RecN/SMC_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45916">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45916:SF1">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02463">
        <property type="entry name" value="SMC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RecF/RecN/SMC N-terminal" evidence="5">
        <location>
            <begin position="12"/>
            <end position="1004"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="269"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="325"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="391"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="606"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="735"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="835"/>
            <end position="876"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAG5108360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="1044" mass="121265" checksum="FA75BEA0C6A33B43" modified="2022-05-25" version="1">MPGEAFRDKGVIRKIYLKDFITYNEVTVTPGRNLNMIIGPNGTGKSTLVSALALGFGATPKTLGKSCQIGDYVRRGCERATIVIHVQHSPQRILQLTRIITTENKSTWMIDGKPVIESKVREVINDLNIQVNNLCQFLPQERVQDFAGLDARQLLISTEKSVGDPRLHGFHTQLIEFRGKEGQMSAEIEQKKSKLDIDKQTFARLEESVSTIKERTTMINKLKKLNQKKAWMEYEDAKKVTSETKAQKDQLSLELIQLRESLAPSDELINRKKSEIRRLENLVNTHNRKITEHEIKLNTTVEKFENCHCDINNIKKESTMEIEQEKSRDQEIKKAEIRKNKLENDKPLLIQELGSVEVITKRFQECDYQVENQKRVTEDLSDKTSRLKNECDKMKYEISNFQRLIKNLKNVEDKRMDILRQYSSDTFEGVQWLRRNTDKFQGKIFEPMILTLQVDHPDHAKYVERVIPHRDLIAFVCESKEDMNLLLTYLREERKLVINAVHSDPNRNYNNRPHIPLDQLRQFGFQNYLIDFIDAPPTVMNYLVSMYHIHNIPIGTAAVENQADHVPDSISLYFSPNNSYSVRRSKYTGDKSTSISQLSGTRYFNVNIDTRKIQALEQKVVELQRHLDDYNQQVEASVGQHQEECRKLDEIRNNKAKIRSDLSQIQKLEADINVAKIKLQKLQSDRKSIEAIKTNAQQRILRAIKKQIGYYAECNQLYEKVVLMSSQAKTDSFKLKLLQQELIKFSEESQILRENVERVKENVDKLEKELVGMRKALREYQEKAIAETDGVSSDDPRFKRIQAAFNKLPATFTEIEEAMQAAKAKLYCLDRTENGEQILAQYDKLSHDIEKLEGEIKALEEKKQESKEQISKLHDEWIPLISGLVEKIGTNFSEYFESVGCVGEIKLNVPENPKDYDQYEMQISVKFRDADELQIFDRQRQSGGEKAFTTAVYMLALQEMCNVPFRCVDEINQGMDPIYERRVMDLLVELTTNRSSSQYFLITPKLLPHLHYNDNCRIHVVHNGPWVQPNDKFNVQHFYSRISV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HQD7</accession>
    <name>A0A8J2HQD7_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS12291</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5106500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HQD7"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5106500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="118" mass="13192" checksum="1EF8E2515ABD5689" modified="2022-05-25" version="1">MKLDVSDVMYDNSSVSSDSGTSQSSHASHDFLSNIANATIPNSIAGSINNGNSAVKKRNRINISWCDVLAMTQDIFFFILCPHNAPHIYYCHCCKNVCLYLCIWFLSLDKIPEIRTID</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HRB8</accession>
    <name>A0A8J2HRB8_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Similar to E2f3: Transcription factor E2F3 (Mus musculus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HICCMSTLAB_LOCUS12954</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the E2F/DP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5107859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HRB8"/>
    <dbReference type="OrthoDB" id="1743261at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090575">
        <property type="term" value="C:RNA polymerase II transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14660">
        <property type="entry name" value="E2F_DD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000008">
        <property type="entry name" value="E2F transcription factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.540">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015633">
        <property type="entry name" value="E2F"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037241">
        <property type="entry name" value="E2F-DP_heterodim"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032198">
        <property type="entry name" value="E2F_CC-MB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003316">
        <property type="entry name" value="E2F_WHTH_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12081">
        <property type="entry name" value="TRANSCRIPTION FACTOR E2F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12081:SF18">
        <property type="entry name" value="TRANSCRIPTION FACTOR E2F2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16421">
        <property type="entry name" value="E2F_CC-MB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02319">
        <property type="entry name" value="WHD_E2F_TDP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01372">
        <property type="entry name" value="E2F_TDP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144074">
        <property type="entry name" value="E2F-DP heterodimerization region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="E2F/DP family winged-helix DNA-binding" evidence="8">
        <location>
            <begin position="134"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="97"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="314"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="202"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="115"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="315"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="329"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAG5107859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="451" mass="50677" checksum="7D5A1DE4A0DEE8D0" modified="2022-05-25" version="1">MPRVRRQVILEDPSRPVTPDMAQTKLIKSEFIDGNSLDELQPQKIAEETPSPHLQDHQYGQTPCYQVTRRPTQPLPRPEQMSVQAVKRRLNLEVASTASSQSAFKAPRVKRRRSGSNSFSNHTPSKSKNLERTRYDTSLSLLTKKFINLVENSNDGVVDLNVASEKLGVQKRRIYDITNVLEGIGILEKKSKNNIQWKGGQLPGERNNILELRQEVTDLEAKENALDRLILGAEESLRELCADRRYAYVTYHDLRSVPAYRDQAIMAVKAPPEATLHVPQPTSNCGQPKLQIHMRSSHGEIEVFLCPDDSTVKNQTTTTSSQLQQSASVLSKSKNPSQLPSELLVTQEQQTHRIEPRMKIKTEYPCAIKREIETISAASGMRDAMLGETDDFEPMGGGKYQLQTEDQMSSDMSILDFGESLMSLEPPLSENDYSFSLASGEGLSDLFDFPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HRQ8</accession>
    <name>A0A8J2HRQ8_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">H15 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS12089</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5106084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HRQ8"/>
    <dbReference type="OrthoDB" id="6754815at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006334">
        <property type="term" value="P:nucleosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005818">
        <property type="entry name" value="Histone_H1/H5_H15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00538">
        <property type="entry name" value="Linker_histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="H15" evidence="2">
        <location>
            <begin position="17"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="144"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5106084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="211" mass="23962" checksum="A0A81007CCC3D286" modified="2022-05-25" version="1">MRVNRGKKISRPARNVNLVLYAMKNLGEENGSTVNNIIEYISDTVEYPASKREVVAALKRGVEFGIMDRKRGRYFLPGEKRRINLSGGNRQDSSSGKSESNVSTVDARATGRSRVSERGHRFKSRNTDKTKREGGGKSKDSSRRKSKPKRKPKQKSKSVKRTRFARSLKSYDLSDYYKNPSYRASGVSSIDSMEYWEDEGPDGYSRPSYIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HSS3</accession>
    <name>A0A8J2HSS3_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Similar to PIK3AP1: Phosphoinositide 3-kinase adapter protein 1 (Gallus gallus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HICCMSTLAB_LOCUS12663</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5107266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HSS3"/>
    <dbReference type="OrthoDB" id="8192811at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005104">
        <property type="term" value="F:fibroblast growth factor receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005068">
        <property type="term" value="F:transmembrane receptor protein tyrosine kinase adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10140">
        <property type="entry name" value="Toll/interleukin-1 receptor homology (TIR) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052446">
        <property type="entry name" value="B-cell_PI3K-Signaling_Adptrs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017893">
        <property type="entry name" value="DBB_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035897">
        <property type="entry name" value="Toll_tir_struct_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16267">
        <property type="entry name" value="BANK1/PIK3AP1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16267:SF11">
        <property type="entry name" value="STUMPS, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14545">
        <property type="entry name" value="DBB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01282">
        <property type="entry name" value="DBB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51376">
        <property type="entry name" value="DBB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DBB" evidence="3">
        <location>
            <begin position="202"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="592"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="695"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="843"/>
            <end position="880"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="646"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="592"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="730"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="763"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="845"/>
            <end position="858"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG5107266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="1042" mass="115310" checksum="A6363735E334EE03" modified="2022-05-25" version="1">MRIRDENRYAERSIAYFGSRSRSGGTKIEGTNAASLMEEREDVVFISSKDSEASALWVNYLTACFEQISRQQGRPPFKVRHVAIEDATAISTTVQDKISKARLQIIVVCPILLEKASNKPEQASALAKQLAPERVLAMMLGVHDGHLTESQKTALITYSQWRKFFVKDQDETFVGEFLGAAVAILGSTTSAALKSDKTTFSVHPKKVKMGQNRVLAILNDPLRPEDTFNVIVDRCGEGKEITQVKKRNPYTLQFSIPEKCLEVSMLVGVRIIVNGIPQGVRQVKCESRLRELDQILRAHDNPLEFMCQTFGFSSGDREQLDNWMVHAFQKNVPPRFNLLATPSGSAPLQRNTISQEEYPTLLHFAARFGLEKLAWQLLDCPGGEVACDLKNVSELTPAELAEQAGHAKLAHQLRGYMQMNEFTNMYSYLKVISENTSGSGASNESAPAQLNSLDTEQDKEDYCQPRPISEAYLVPPAARPVITSAPISCAPPQLPPPNPPTSPNPCEMNYSIVPPPTPVVGALFSPTTPPVNFEANGLSLPLQGYLKMQPAGPKLSSAPITAPLMALKPTMSQSLRKDFPINREDFMNTNLSNLGGSLNRSTSYPGTKSREASGPQDELLEIITDFKNNVFTISEVERLVENWRNRNDVQQSFKDKQRQLASMRDEYERIQKKIKEEMKAPTPFDRFKKLFTKSKKEAKESSSSQDDDSASTHSKTDNKSNGTLSDRRPISSLSLHSVSSSSSSGRMSVISGCSGTSLGDSGTHSDTEDRRLRNSREDKGGMMTYEIPPAPKPFTGRYSPLRYTPSPRSSTNCIDEHRRHPTPAPDQYYIAFPVSGLPVHPFNADGTSTEPKTPSSPCDHSFGPPMSIPEEQQPHPELNENNDCQKQIKELNQLSIPSPPPSPPTHIPLDYMNITPTANSNDLKNVLSDVNNSCDIKKNNTDNDASQMSSELNKVINKDYNNPDEPVNLQDTNIQSNHVENVPLSVDVVDAPVLHDYMNIQPCDQDPRVVGVIPKKPPAPPVPPRGIKSTYLLSTGNGSYFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HSY5</accession>
    <name>A0A8J2HSY5_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS13989</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5109353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HSY5"/>
    <dbReference type="OrthoDB" id="5920040at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331:SF1">
        <property type="entry name" value="GAG-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331">
        <property type="entry name" value="PHD-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CCHC-type" evidence="2">
        <location>
            <begin position="66"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="2">
        <location>
            <begin position="100"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="40"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5109353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="308" mass="34128" checksum="82D9232E98DD1A54" modified="2022-05-25" version="1">MTDEKIKALTTKRAGAKRSLASRAQVEGVRLQNPKPASERSNNINNNNRSNTRSQQTFATTTHEQSCVFCGENTHLVYNCTQFAALDPHTRYEASRNGGWCTNCLRKGHRASKCTSQPCRNCKLKHHTLLHFEKANNSSNQSVTAQVSSHFVANSTILQAQTSSHVLLATALVDMVNHQGNSKTIRAMPSITINQSSLDIPKNIKLADPDFFKSSKVDALIGVKFRMQRVIACILRFIHNVKKPSSERKFGPLLSTELNPRRLAKKLDIVGWKVKSFDPSALAAALNSEPLTTGSAEEMTKDLMKRVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MAS7</accession>
    <name>A0A8J2MAS7_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">HTH CENPB-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HICCMSTLAB_LOCUS2984</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001117">
        <property type="protein sequence ID" value="CAG5079328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MAS7"/>
    <dbReference type="OrthoDB" id="7697906at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006600">
        <property type="entry name" value="HTH_CenpB_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007889">
        <property type="entry name" value="HTH_Psq"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05225">
        <property type="entry name" value="HTH_psq"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03221">
        <property type="entry name" value="HTH_Tnp_Tc5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51253">
        <property type="entry name" value="HTH_CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50960">
        <property type="entry name" value="HTH_PSQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH psq-type" evidence="5">
        <location>
            <begin position="12"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="domain" description="HTH CENPB-type" evidence="6">
        <location>
            <begin position="66"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="4">
        <location>
            <begin position="40"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAG5079328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="181" mass="21030" checksum="A8DE67843FA3294C" modified="2022-05-25" version="1">MTPKAPAKKKKSVQNRQRCQYTPEDLENAVNSIRNSELSMNKASQMYNIPKATLSIKVKQNHAVQCKLGRSTILTTDEEDKIKNWILNKAKLGFPMCREDIKNAVQKVLKETKRDNPVIDDRPGRKWMELFLNRHPEISLRNSEVLSKARACVTEEGIREWFTGLQNHIEIDQKINFSFNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MBZ0</accession>
    <name>A0A8J2MBZ0_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS2925</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001117">
        <property type="protein sequence ID" value="CAG5079109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MBZ0"/>
    <dbReference type="OrthoDB" id="7694116at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5079109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="61" mass="7171" checksum="AB377CF9FCD1B414" modified="2022-05-25" version="1">MPNFSTTIFEHSFVISAIRLWRKLPTETTESLSQDSFKSNAFEFFVKLERDSYAKYLDSVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MFH0</accession>
    <name>A0A8J2MFH0_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Similar to CSTF2: Cleavage stimulation factor subunit 2 (Bos taurus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HICCMSTLAB_LOCUS4745</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5088175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MFH0"/>
    <dbReference type="OrthoDB" id="272703at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005847">
        <property type="term" value="C:mRNA cleavage and polyadenylation specificity factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031124">
        <property type="term" value="P:mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12671">
        <property type="entry name" value="RRM_CSTF2_CSTF2T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.70:FF:000001">
        <property type="entry name" value="Cleavage stimulation factor subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.630:FF:000001">
        <property type="entry name" value="Cleavage stimulation factor subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000061">
        <property type="entry name" value="cleavage stimulation factor subunit 2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.70">
        <property type="entry name" value="Transcription termination and cleavage factor, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025742">
        <property type="entry name" value="CSTF2_hinge"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026896">
        <property type="entry name" value="CSTF_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038192">
        <property type="entry name" value="CSTF_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45735">
        <property type="entry name" value="CLEAVAGE STIMULATION FACTOR SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45735:SF2">
        <property type="entry name" value="CLEAVAGE STIMULATION FACTOR SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14327">
        <property type="entry name" value="CSTF2_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14304">
        <property type="entry name" value="CSTF_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="9">
        <location>
            <begin position="17"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="329"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAG5088175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="462" mass="50194" checksum="6DE857B65F390A82" modified="2022-05-25" version="1">MTNTAISDQSLMDKSMRSVFVGNIPYEATEEGLKDIFSEVGPVLSFKLVYDRETGKPKGYGFCEYKDQETALSAMRNLNGHETNGRTLRVDNACTEKSRMEMQVLLQGQNTENPYGEAVQADKAPEAISKAVASLPPEQMFELMKQMKLCVQNNPNEARQMLLQNPQLAYALLQAQVVMRIVDPHTAVSMLHKANPIPSVLQAADKPAVPTTTVPAIHTSIPPPRIEEAWAAARAAVPPAINPPAPIFANQDVDLRTLDRQIDPRLARMDQDLRAPAQPQIPQPIAPVSVPPVIPPSVVDTRNTGFMPDKFNNLSSALPAEGIESFCRDPRADRFGRDPRDPRMTIDPRIPKVNAPAAIVPPPVQRPVVTSTVPPPIAPSTLNSTQPPTTAGIPSNNSTATSRLMAGMSSSGSIPSGASDQEKAALIMQVLQLSDEQIAMLPPEQKQSILVLKEQIAKSTQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MGJ6</accession>
    <name>A0A8J2MGJ6_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS2775</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001117">
        <property type="protein sequence ID" value="CAG5078549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MGJ6"/>
    <dbReference type="OrthoDB" id="7169281at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="15"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5078549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="97" mass="10914" checksum="2D10B388885BE1FC" modified="2022-05-25" version="1">MACPFSRGFTRTKLESDREGCDDGGSSGRKFSNDSIGKLPCKNERFKTCRQSSIQITSSLLGEEIDDQEDTQTLNLKHLRAAVLILTKPSVIFDYFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MGV9</accession>
    <name>A0A8J2MGV9_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="21">Fructose-1,6-bisphosphatase isozyme 2</fullName>
            <ecNumber evidence="8">3.1.3.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">D-fructose-1,6-bisphosphate 1-phosphohydrolase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="22">D-fructose-1,6-bisphosphate 1-phosphohydrolase 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="23">Muscle FBPase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="27" type="ORF">HICCMSTLAB_LOCUS5775</name>
    </gene>
    <organism evidence="27 28">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="27" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="19">Catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate in the presence of divalent cations and probably participates in glycogen synthesis from carbohydrate precursors, such as lactate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>beta-D-fructose 1,6-bisphosphate + H2O = beta-D-fructose 6-phosphate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:11064"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:32966"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="EC" id="3.1.3.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="6">Carbohydrate biosynthesis; gluconeogenesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="20">Homotetramer. Interacts with ALDOA; the interaction blocks inhibition by physiological concentrations of AMP and reduces inhibition by Ca(2+). Interacts with alpha-actinin and F-actin.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell junction</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
            <location evidence="4">Myofibril</location>
            <location evidence="4">Sarcomere</location>
            <location evidence="4">Z line</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7 24">Belongs to the FBPase class 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="27">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.11" evidence="8"/>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5090872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MGV9"/>
    <dbReference type="OrthoDB" id="10256725at2759"/>
    <dbReference type="UniPathway" id="UPA00138"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070161">
        <property type="term" value="C:anchoring junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030018">
        <property type="term" value="C:Z disc"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042132">
        <property type="term" value="F:fructose 1,6-bisphosphate 1-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030388">
        <property type="term" value="P:fructose 1,6-bisphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006002">
        <property type="term" value="P:fructose 6-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006000">
        <property type="term" value="P:fructose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005986">
        <property type="term" value="P:sucrose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00354">
        <property type="entry name" value="FBPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.190.80:FF:000001">
        <property type="entry name" value="Fructose-1,6-bisphosphatase class 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.540.10:FF:000005">
        <property type="entry name" value="Fructose-1,6-bisphosphatase isozyme 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.540.10">
        <property type="entry name" value="Fructose-1,6-Bisphosphatase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01855">
        <property type="entry name" value="FBPase_class1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044015">
        <property type="entry name" value="FBPase_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000146">
        <property type="entry name" value="FBPase_class-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033391">
        <property type="entry name" value="FBPase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028343">
        <property type="entry name" value="FBPtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020548">
        <property type="entry name" value="Fructose_bisphosphatase_AS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006778">
        <property type="entry name" value="PRK09293.1-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11556">
        <property type="entry name" value="FRUCTOSE-1,6-BISPHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11556:SF1">
        <property type="entry name" value="FRUCTOSE-BISPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00316">
        <property type="entry name" value="FBPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18913">
        <property type="entry name" value="FBPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500210">
        <property type="entry name" value="FBPtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000904">
        <property type="entry name" value="FBPtase_SBPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00115">
        <property type="entry name" value="F16BPHPHTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56655">
        <property type="entry name" value="Carbohydrate phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00124">
        <property type="entry name" value="FBPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0106">Calcium</keyword>
    <keyword evidence="17 24" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="15" id="KW-0965">Cell junction</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12 24" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="28" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fructose-1-6-bisphosphatase class I N-terminal" evidence="25">
        <location>
            <begin position="14"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="Fructose-1-6-bisphosphatase class 1 C-terminal" evidence="26">
        <location>
            <begin position="206"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00004742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00010941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00013093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00032973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00037516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00038670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00040321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00042757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00043165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="RuleBase" id="RU000508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="Pfam" id="PF00316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="Pfam" id="PF18913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="EMBL" id="CAG5090872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="338" mass="36734" checksum="5434E41C0249543A" modified="2022-05-25" version="1">MALHESSFDTKCVTLTSFVLSEQKKISGATGDFTLLINAIQTAVKAISSAIRKAGIAKLYGISGETNVQGEKTTKLDKLSNEIFINVLSSTCTTCILISEENETPIIVAKEKRGKYVVCFDPLDGSSNIDCLVSIGSIFSIYKSSGITMESELKNVIRSSDNLIAAGYALYGSATMIVLSVGQSVNGFTYDPAIGEFMLTEQNIKIPTRGNIYSINEGSEGTWEVAIKEYIKSKKYPAKGKSYGARYVGSMVADIHRTMKYGGIFLYPSTSAYPNGKLRLLYECIPMAYIIKNAGGKASTGKIDLLDVIPEEIHQRTPIFLGSPEDVDDLLTFTKSSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MH16</accession>
    <name>A0A8J2MH16_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similar to NOF: 120.7 kDa protein in NOF-FB transposable element (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS3047</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001117">
        <property type="protein sequence ID" value="CAG5079579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MH16"/>
    <dbReference type="OrthoDB" id="7700880at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="723"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="765"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="726"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="765"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="778"/>
            <end position="793"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5079579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="997" mass="114789" checksum="272819232E66ADA5" modified="2022-05-25" version="1">MAPRAQVSVESAVNALKKHIKYFIPPEKPKWSSKIWRIISDELGNQWNENAVRTNVNQNRRNILSIALQECGYFRGEINTESSKYDDLQDENVDSSSSDEDDDSNDPDYCDQAAYFNNIEEIQEFDVEISKELWNSVVKPSAGNSQPKLNKGAWTSIIAYAFWEQYRLKCCFIFDKGYINVNVKAHCKSKKCGNRLFGFIEGVPFDEGPVYIKIKCCDTRFIEKHEDFQRPLRGETRKAVSQQVRNLGVHAYNRRAAIKLLRSGDTACPFLYKPNVLHQAKKQFLDNERGIKPIDRKDIFPAIDRINENPLYRNSILLVGKPFFVFYATQSQMHCYKEYRRLNKKSSICIDATGGLVRKIISEGKKSSYIFLYQIVINFNKTSQCVYQMLTEMQDAHTITMWLNKWVSAVKLLPHEAVSDGSRAQLNAMSRAFNDMSLKQYIKLCFESIKNPQKLTDIKTYIRLDVAHFVHTITGWSCFKSAVHPSVKKFYIYCICLLIDCKEFSKFERILMLILIISNTAHEDSVVYVKDEKFTPLTARTELENLIMSRKVEEFFLNVSEQIEKMEVDPEKNKFRDTELENSEKDSVSISCWIKNLLKVSKNVFYQGNNLQSFFLPALENPLVEAVVEFPLWTNICIPHSDVLGTSSYIEEDFKDLKEAMRRQVSLPTDVYTFLKLHLDYLIGGVSLFRMKITKFIDEHINNTEKSLPDLLNCNLSEINVEEDDSSKNLMKEEEKNKYKSSDSELMDTTNTSLSKIIVKEDDSFKNSMKGEEKKNNSSDSEPIDTTNTSNQFDQGVSITSDINKQIKFDLNTDNSVNVNYNLSDIIEKKNKNDPFENWRGKGKNNKLNPFDWMSSGESADGNEAKPEIRTNFIPKDVGKFSNITHVNDDINLNNANSKIKLANNYPKDHDSNIKTYQVDDDSRGITKTKALKDHDYGFTTSTPLEDKKPKKTLAAAIDKISRQNINSGKYFNDCPEMKLQNKFVEARKESVTSEEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MIA3</accession>
    <name>A0A8J2MIA3_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HICCMSTLAB_LOCUS6745</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5093317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MIA3"/>
    <dbReference type="OrthoDB" id="10369204at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13920">
        <property type="entry name" value="zf-C3HC4_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="1 3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="4">
        <location>
            <begin position="326"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAG5093317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="385" mass="43734" checksum="3C09456643617CCA" modified="2022-05-25" version="1">MVVADLENHAVPCMIVIGKQRKEASYSEALGIIAATIPSIKMVYTNFEVRLRNQLAIKYDLHKDDNDTIIIRKVIALSMILSTATQQLYFILWQSSPLTERTRFEPFLTDFNKIWIQNAVNECCAYENMAIFNDCQRSALLYVATPRTRALVDKAQYCENARVLEKEQITLNTFIKSCSFLVRDILENCKFEREYEAETDTDCFSDNNSQNSSLKSGLDLQSIGFINDTDIYEELDYKSKLEKITQLTDDTDNIMESESEDVAVSVQTEEVADVQPEQAADAQPTEVTVVQDPMSIERATTLVQMIEENENPAVNLLNQDGDPILCVACFTSETQNIFSPCGHTTLCRHCTTKILFQFISGATPEFKCNVCWSPFEELQQLLFID</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2025-06-18" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MJE1</accession>
    <name>A0A8J2MJE1_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Pre-mRNA-processing-splicing factor 8</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Splicing factor Prp8</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HICCMSTLAB_LOCUS5382</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Plays a role in pre-mRNA splicing as core component of precatalytic, catalytic and postcatalytic spliceosomal complexes, both of the predominant U2-type spliceosome and the minor U12-type spliceosome. Functions as a scaffold that mediates the ordered assembly of spliceosomal proteins and snRNAs. Required for the assembly of the U4/U6-U5 tri-snRNP complex, a building block of the spliceosome. Functions as a scaffold that positions spliceosomal U2, U5 and U6 snRNAs at splice sites on pre-mRNA substrates, so that splicing can occur. Interacts with both the 5' and the 3' splice site.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5089806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1931567at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097157">
        <property type="term" value="F:pre-mRNA intronic binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030619">
        <property type="term" value="F:U1 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030620">
        <property type="term" value="F:U2 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030623">
        <property type="term" value="F:U5 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017070">
        <property type="term" value="F:U6 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000244">
        <property type="term" value="P:spliceosomal tri-snRNP complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08056">
        <property type="entry name" value="MPN_PRP8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13838">
        <property type="entry name" value="RNase_H_like_Prp8_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.80.40:FF:000001">
        <property type="entry name" value="Pre-mRNA-processing-splicing factor 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.230:FF:000003">
        <property type="entry name" value="Pre-mRNA-processing-splicing factor 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.43.40:FF:000001">
        <property type="entry name" value="Pre-mRNA-processing-splicing factor 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.10:FF:000002">
        <property type="entry name" value="Pre-mRNA-processing-splicing factor 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1570.40:FF:000001">
        <property type="entry name" value="Pre-mRNA-processing-splicing factor 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.80.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1570.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.40">
        <property type="entry name" value="Pre-mRNA-processing-splicing factor 8, U5-snRNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000555">
        <property type="entry name" value="JAMM/MPN+_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012591">
        <property type="entry name" value="PRO8NT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012592">
        <property type="entry name" value="PROCN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012984">
        <property type="entry name" value="PROCT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027652">
        <property type="entry name" value="PRP8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021983">
        <property type="entry name" value="PRP8_domainIV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043173">
        <property type="entry name" value="Prp8_domainIV_fingers"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043172">
        <property type="entry name" value="Prp8_domainIV_palm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019581">
        <property type="entry name" value="Prp8_U5-snRNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042516">
        <property type="entry name" value="Prp8_U5-snRNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019580">
        <property type="entry name" value="Prp8_U6-snRNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019582">
        <property type="entry name" value="RRM_spliceosomal_PrP8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11140">
        <property type="entry name" value="PRE-MRNA SPLICING FACTOR PRP8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11140:SF0">
        <property type="entry name" value="PRE-MRNA-PROCESSING-SPLICING FACTOR 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01398">
        <property type="entry name" value="JAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08082">
        <property type="entry name" value="PRO8NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08083">
        <property type="entry name" value="PROCN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08084">
        <property type="entry name" value="PROCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12134">
        <property type="entry name" value="PRP8_domainIV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10598">
        <property type="entry name" value="RRM_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10597">
        <property type="entry name" value="U5_2-snRNA_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10596">
        <property type="entry name" value="U6-snRNA_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00232">
        <property type="entry name" value="JAB_MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="MPN" evidence="11">
        <location>
            <begin position="2142"/>
            <end position="2273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00055739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00071757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00079260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAG5089806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="2374" mass="276900" checksum="6FC5F66877F593BC" modified="2022-05-25" version="1">MSIPPYLLGPNPWATMLAQQQAHAQLAAAQAHAQAAAQAAHHVHVQAMAAGPPLPQMPKQPEVLSEEKLQEKAQKWQQLQSKRFAEKRKFGFVDAQKEDMPPEHIRKIIRDHGDMSSRKYRHDKRVYLGSLKYMPHAVMKLLENMPMPWEQIRDVKVLYHITGAITFVNEIPWVIEPVYIAQWGTMWIMMRREKRDRRHFKRMRFPPFDDEEPPLDYADNILDVEPLEAIQIDLDSEDDKPVADWFYEHKPLVGTKFINGPTYRKWNLSLPQMATLYRLANSLLTDLVDQNFFYLFDPKSFFTAKALNMAIPGGPKFEPLVKDSNAADEDWNEFNDINKIIIRQPIRTEYRIAFPYLYNNMPHFVHLSWYHAPNVVYIKTEDPDLPAFYFDPLINPISHRNSLKTVEPQIEEDEDFVLDEEIQPFLQETPLYTDNTANGIALLWAPRPFNTRSGRTRRAIDIPLVKSWYREHCPPGQPVKVRVSYQKLLKYFVLNALKHRHPKPQKRRYLFKSFKATKFFQTTTIDWVEAGLQVCRQGYNMLNLLIHRKNLNYLHLDYNFNLKPVKTLTTKERKKSRFGNAFHLCREILRLTKLIIDSHVQYRLNNVDAFQLADGLQYIFAHVGQLTGMYRYKYKLMRQIRMCKDLKHLIYYRFNTGPVGKGPGCGFWAPGWRVWLFFMRGITPLLERWLGNLLSRQFEGRHSKGVAKTVTKQRVESHFDLELRASVMHDIVDMMPEGIKQNKARTILQHLSEAWRCWKANIPWKVPGLPIPIENMILRYVKMKADWWTNTAHYNRERIRRGATVDKTVCKKNLGRLTRLYLKAEQERQHNYLKDGPYISPEEAVAIYTTTVHWLESRRFAPIPFPPLSYKHDTKLLILALERLKEAYSVKSRLNQSQREELGLIEQAYDNPHEALSRIKRHLLTQRAFKEVGIEFMDLYSHLIPVYDVEPLEKITDAYLDQYLWYEADKRKLFPPWVKPSDSEPPPLLVYKWCQGINNLQDVWDVNEGECNVLLESKFEKLYEKIDLTLLNRVLRLIVDHNIADYMTAKNNVVINYKDMNHTNSYGIIRGLQFASFIAQYYGLVLDLLVLGLQRASEMAGPPQMPNDFLTFQDVASEAAHPIRLYCRYVDRIHLFLRFSADEARDLIQRYLTEHPDPNNENIVGYNNKKCWPRDARMRLMKHDVNLGRAVFWDIKNRLPRSTTTIQWENSFVSVYSKDNPNLLFNMSGFECRILPKCRTIHEEYTTARDGVWNLQNEITKERTAQCFLRVDDESLQRFHNRVRQILMASGSTTFTKIVNKWNTALIGLMTYFREAVVNTQELLDLLVKCENKIQTRIKIGLNSKMPSRFPPVVFYTPKELGGLGMLSMGHVLIPQSDLRWSKQTDVGITHFRSGMSHDEDQLIPNLYRYIQPWESEFIDSQRVWAEYALKRQEASAQNRRLTLEDLEDSWDRGIPRINTLFQKDRHTLAYDKGWRIRTEFKQYQVLKQNPFWWTHQRHDGKLWNLNNYRTDMIQALGGVEGILEHTLFKGTYFPTWEGLFWEKASGFEESMKYKKLTNAQRSGLNQIPNRRFTLWWSPTINRANVYVGFQVQLDLTGIFMHGKIPTLKISLIQIFRAHLWQKVHESIVMDLCQVFDQELDALEIETVQKETIHPRKSYKMNSSCADILLFSAYKWNVSRPSLLADSKDSMDNTTTQKYWIDVQLRWGDYDSHDIERYARAKFLDYTTDNMSIYPSPTGLLIAIDLAYNLHSAYGNWFPGCKPLIQQAMAKIMKANPALYVLRERIRKALQLYSSEPTEPYLSSQNYGELFSNQIIWFVDDTNVYRVTIHKTFEGNLTTKPINGAIFIFNPRTGQLFLKIIHTSVWAGQKRLGQLAKWKTAEEVAALIRSLPVEEQPKQIIVTRKGMLDPLEVHLLDFPNIVIKGSELQLPFQACLKVEKFGDLILKATEPQMVLFNLYDDWLKTISSYTAFSRLILILRALHVNTERTKVVLKPDKTTITEPHHIWPSLTDDEWIKVEVQLKDLILADYGKKNNVNVASLTQSEIRDIILGMEISAPSAQRQQIAEIEKQTKEQSQLTATTTRTVNKHGDEIITATTSNYETQTFSSKTEWRVRAISATNLHLRTNHIYVSSDDIKETGYTYILPKNVLKKFVTISDLRAQIAGYLYGISPPDNPQVKEIRCIVMAPQWGTHQTVHLPTSLPNHQYLKEMEPLGWIHTQPNELPQLSPQDISTHARVMADNPVWDGEKTIVITCSFTPGSCSLTAYKLTPSGFEWGKQNTDKGNNPKGYLPSHYEKVQMLLSDRFLGFFMVPSQGSWNYNFMGVKHSPNMKYELQLANPKEFYHEIHRPGHFLNFSSLEDGDGVGADREDHYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MK54</accession>
    <name>A0A8J2MK54_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Similar to ZNF836: Zinc finger protein 836 (Homo sapiens)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HICCMSTLAB_LOCUS5776</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5090874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MK54"/>
    <dbReference type="OrthoDB" id="8895262at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000100">
        <property type="entry name" value="Zinc finger 45-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000446">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24381:SF393">
        <property type="entry name" value="CHROMATIN-LINKED ADAPTOR FOR MSL PROTEINS, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24381">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13912">
        <property type="entry name" value="zf-C2H2_6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12874">
        <property type="entry name" value="zf-met"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="19"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="16"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="18"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="190"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="303"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="333"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="361"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="389"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="421"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="450"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="478"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="507"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="534"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="562"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="590"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="618"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="646"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="674"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="702"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="730"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="758"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="254"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAG5090874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="799" mass="94358" checksum="E87B513184F91D99" modified="2022-05-25" version="1">MKNSNLPTFNMKKIILVSNNNEMRRQLIVNNQSSVNTNYNCYSFLNKSTDIKITSVQSLSGTENCWNENIDNIENGHVQTICDENETKFSISELTINENSSTEIADTTNTNRQELPFTFIADTNITLENSFNPLDVIVKQENDVDPLATDVKPDQQELNKVLLENYNKESCILEGLLKQYKRTKISNKKFECDMCPKKYVLKQSLQRHKAVHVKKLKFPCKICYFQTNSNSLLKKHITNNHHITRPVLRDVRGSKLSQSSQFKKKNHKTGKISQKNNTRCLKSMKKSLLKKSIKNRQCLQKSHTCKVCHKVYATKHTLERHKIVHVIKKKQNFQCEVCNLICTRQSSLGKHLKTHLNNEIFKCDICKKIFRRKLTLIRHMDLHDLKIRVECDNCHLTYTRKSSLIRHMRSCFWNLPADRPFTCDICNSNYSRKSHLESHIIHHHLKGVHVNCKICLRNFSRTSSLEHHMLIHIRGKIYKCDICHSKYTEETSLAQHMSDTHKNEESFKCDNCQAEFLTKQNLSIHMRCHKTERFECTICQRSFSRNFNLKQHMYTHTNENVFKCNICHLKFTQESMLTTHLENHTRDKQYKCDVCEAIFRQKSKLNKHRLTHTREKSFECDICQAFFSHKFILDKHKLTHTREKSFHCDICPSQFCSQYNLDKHLVLHTRKELFECNVCHSKFIHKSQLKTHLYSHSDKKIFKCDICERIFSHHFSLKRHKLIHTGNKQFKCDACLAKFFTIQSLTKHIKKSHKNKEYKCDICKKHFSAKGWLDRHRLIHAKDELVCSTKNERLDHTSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MKU8</accession>
    <name>A0A8J2MKU8_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="4">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HICCMSTLAB_LOCUS6483</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SINA (Seven in absentia) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="4"/>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5092964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MKU8"/>
    <dbReference type="OrthoDB" id="4788989at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010498">
        <property type="term" value="P:proteasomal protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000041">
        <property type="entry name" value="E3 ubiquitin-protein ligase SINAT3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052088">
        <property type="entry name" value="E3_ubiquitin-ligase_SINA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013010">
        <property type="entry name" value="Znf_SIAH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10315">
        <property type="entry name" value="E3 UBIQUITIN PROTEIN LIGASE SIAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10315:SF117">
        <property type="entry name" value="RING-TYPE E3 UBIQUITIN TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21361">
        <property type="entry name" value="Sina_ZnF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49599">
        <property type="entry name" value="TRAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51081">
        <property type="entry name" value="ZF_SIAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="11">
        <location>
            <begin position="90"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="SIAH-type" evidence="12">
        <location>
            <begin position="144"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAG5092964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="331" mass="38319" checksum="397E48122FCE083B" modified="2022-05-25" version="1">MFEKLISFFKKSGIKKNNSLAQLTPDEKCELKKLQSVPNLKEYGKKHCNFYTFVPISCTGTSDGYDEAISDEENVVGNRLRQKIITDGLCKICLESLQMRRIFSCITCNKIVCADCFSKLRHCPYCRNPTISKRERNLEQFVNSLALPCKNFSNGCNKLIKSNNRRNHESACRYNDLECPIGHKSCKWNGIATELLSHLKEQHLIAPTNGYGLTIVINDFWKKMSFKSDIEHKFLECYHQLFYLRVTYQGGVLSTSLKKLIFLTDVSDSVKETLKQFNVHVTIRTDNTKKYEQVYLIKDKRSSKFFIDCGRLLADDIFDFIKVEFKILLTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MNT2</accession>
    <name>A0A8J2MNT2_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to DOK7: Protein Dok-7 (Homo sapiens)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS7423</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5094866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6537982at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007528">
        <property type="term" value="P:neuromuscular junction development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14677">
        <property type="entry name" value="PH_DOK7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037746">
        <property type="entry name" value="Dok-7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037747">
        <property type="entry name" value="Dok-7_PH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002404">
        <property type="entry name" value="IRS_PTB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21636">
        <property type="entry name" value="PROTEIN DOK-7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21636:SF2">
        <property type="entry name" value="PROTEIN DOK-7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02174">
        <property type="entry name" value="IRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01244">
        <property type="entry name" value="IRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51064">
        <property type="entry name" value="IRS_PTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IRS-type PTB" evidence="2">
        <location>
            <begin position="110"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="212"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="291"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="447"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="690"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="968"/>
            <end position="992"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1020"/>
            <end position="1045"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1059"/>
            <end position="1081"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1113"/>
            <end position="1169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1244"/>
            <end position="1296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1363"/>
            <end position="1386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="291"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="301"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="319"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="330"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="447"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="476"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="540"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="574"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="690"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="968"/>
            <end position="984"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1020"/>
            <end position="1033"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1068"/>
            <end position="1077"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1117"/>
            <end position="1131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1151"/>
            <end position="1165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1255"/>
            <end position="1269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1270"/>
            <end position="1281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1285"/>
            <end position="1296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1368"/>
            <end position="1378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5094866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="1396" mass="153690" checksum="B122B9A23AEE1FDA" modified="2022-05-25" version="1">MVDNNCIIEGNVKFRDGKKWKSRWCVMRKLSPVADCLHLQLYGDSKDRYNKQGQTKASLSLQHFLGIESGFTLDKESNTIAIICQDLIVVLAFDTRERLIQWQVKISNNLGEDQQFLIIISSAPSKAKVSNGPAHLHIQDRRFCLTVGVPPRLIGVWELAHLRRYGVVEGRFCFEGGSRCGRGEGLHVLITDQGEDIVRTLQLAAEGKLATRKRPLNPQLSSQDSPTRRQFIRSDTRVSDFFPSNVSYTSSVTYKDHEGIKTETTSPCWSSTESRHFELDAVDYNTSYRDTVGSTQELSDQQQQQQQQQQQQQQQQQQHNTYNFTSSPPTTTTTTTATTTTTTTTTTTTTTTTTTTTTNTNTAAATTSTLTISSINYQHQNQQQSNQITEWRSGSLPRQNTSGIERCASCISKLGAISKNSVITSSNNTSSHTNTICSSPSSGNNIFNNFTNNNNNNNNNNSTTCHSQQPRAFDRLSLSSYSSSSHDSDYSGSQNADSVCLSSSSKNSPSLPSKDSSCLLLKNSPEEPQLADQEQQQQSEENKDNKENKEEDKDKFEKLNTLPSPTTLPPRPAKPSNKNIYNINNKNKNKKPPMPLPNERCTCKQKSTITKSSPYDNYDIPKSILAHHMSLEPATNQGDQYYDTPRKIKECLALPKNYPNYDTPHSAPQAVMLKQCGCPAKLSSLASFSSSSSSSSSSATSSSSSSSRLGGCPCHNVMSWAGFVLPYCRRGAGIEPTGVAVHPIKLSGQGKMPVVNANGELAIYPTILNNKKLDDSINNTTTTISNCTTTSSSSNITTANNYENIEPIVVIDTQPESKLGNYVNIDFTESLEYYENSRDLIAKAGISQEEMNEIAEDLKQQSIDINDDDDDDDDDEIKSQVIQDKVCNKCGHVKDNNSSSLNNYLVMNPDNNKPKQFKKSFPGYLPMQPSISPHNACSKEVISRICGTKSSSNPTLFGSSSSSSSLLLLSSSSSSPSSSSSSPLVEINRKRSDSELRIPGSAMLSSPYLRRRLIDPSIFHNQQQQQQQQQQQHNNHHNNHGESSNLEILWRKRSYSTESPSSNYLEDSSPSPGFSSSTIHKCPSDSGEKLIMLTKDQPIITCSDLKINNRDNDDESTQIVGHNNGHSTGFSSIKIRRSSSVPSKTGHNRDSSSSNDSGVSTGSLSHRNGEFGECDITTTTLPINGIINLSSKKQNNIITTICNRKSPPPVTICYHGSLPRKSKSSDPLRELSFQFQKIKIPTKSCSTEGDIPKQNNNNNNNNNNNNTNNKGYSSPGENSGTPYIDSRSTSSGTSDMSDYIETLSLSSHSSSDTPDSLRGRAVATTLRPRSGKEYYKIDRSILAEQSRNLSTSGSSYANITPVLEKSESPSPGYISSSPFEQPPPSREHFIFSEVNC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MP15</accession>
    <name>A0A8J2MP15_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Odorant receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HICCMSTLAB_LOCUS9014</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Cell membrane</location>
            <topology evidence="1 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the insect chemoreceptor superfamily. Heteromeric odorant receptor channel (TC 1.A.69) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5098063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MP15"/>
    <dbReference type="OrthoDB" id="7179992at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005549">
        <property type="term" value="F:odorant binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004984">
        <property type="term" value="F:olfactory receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004117">
        <property type="entry name" value="7tm6_olfct_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21137">
        <property type="entry name" value="ODORANT RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21137:SF35">
        <property type="entry name" value="ODORANT RECEPTOR 19A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02949">
        <property type="entry name" value="7tm_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 10" id="KW-0552">Olfaction</keyword>
    <keyword evidence="8 10 11" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="9 10" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="42"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="125"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="178"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="244"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="270"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU351113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAG5098063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="373" mass="42203" checksum="184D09791D4832B1" modified="2022-05-25" version="1">MFKVDPEFAIAYTKLTVTLVCSWPPGRNSSKRDLVVFNVKWWISWLLGIFLVVPLIYAAVVDRKNVLEFTKSLCLAVSCGQCAVKMFFCKLQNQRIKFLLDEMEEYVKVSVPSERQIFLNYIKNCGLVHVVLNVCSLVASIGVILGPLVLPQRLPTEAKYPFSVETHPNYEIIYVHQAFAGVLCSSIGSIDCQIAMLLWYSIARLDILSLEMEKITSVCQFYKCVRKHQYLLWFVDETIKAGRCLVATTVIMTTLAVILGGVHIVGNEPLIAKLQFVIIVGGFSILLYVTAWPSEILTRMCENVGWTIYNSPWLKNSKELNKGIEFVIQRSNKPAVISLSGVFPALSLNYYATFLSKTFSYFTTLRIILAKME</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MPH3</accession>
    <name>A0A8J2MPH3_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">arginine kinase</fullName>
            <ecNumber evidence="2">2.7.3.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HICCMSTLAB_LOCUS10707</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 7 9">Belongs to the ATP:guanido phosphotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.3.3" evidence="2"/>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5101822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MPH3"/>
    <dbReference type="OrthoDB" id="430219at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004054">
        <property type="term" value="F:arginine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004111">
        <property type="term" value="F:creatine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046314">
        <property type="term" value="P:phosphocreatine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07932">
        <property type="entry name" value="arginine_kinase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.590.10:FF:000006">
        <property type="entry name" value="Arginine kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.135.10:FF:000003">
        <property type="entry name" value="Three-domain arginine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.135.10">
        <property type="entry name" value="ATP:guanido phosphotransferase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.590.10">
        <property type="entry name" value="Glutamine synthetase/guanido kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000749">
        <property type="entry name" value="ATP-guanido_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022415">
        <property type="entry name" value="ATP-guanido_PTrfase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022414">
        <property type="entry name" value="ATP-guanido_PTrfase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022413">
        <property type="entry name" value="ATP-guanido_PTrfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036802">
        <property type="entry name" value="ATP-guanido_PTrfase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11547:SF38">
        <property type="entry name" value="ARGININE KINASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11547">
        <property type="entry name" value="ARGININE OR CREATINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00217">
        <property type="entry name" value="ATP-gua_Ptrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02807">
        <property type="entry name" value="ATP-gua_PtransN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="Glutamine synthetase/guanido kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48034">
        <property type="entry name" value="Guanido kinase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00112">
        <property type="entry name" value="PHOSPHAGEN_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51510">
        <property type="entry name" value="PHOSPHAGEN_KINASE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51509">
        <property type="entry name" value="PHOSPHAGEN_KINASE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 8 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phosphagen kinase N-terminal" evidence="10">
        <location>
            <begin position="144"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphagen kinase C-terminal" evidence="11">
        <location>
            <begin position="256"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="259"/>
            <end position="263"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="322"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="366"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="417"/>
            <end position="421"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="446"/>
            <end position="451"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAG5101822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="493" mass="56001" checksum="77501A16CA27372A" modified="2022-05-25" version="1">MQCHTIPLVVYSLLCKLKYLECHRKKKQKKKKGRAWYAILGTKSQVHHEPPGIIRQLCKLHVYSSTYPKINSRRASQYFYPSLLVSLYHISESHHVNLKNTSLVFPVSMLKFDFKNINKLSLVCINITNQYRIKDIGFTVQFLLLDKLEAGFTKLQNSDSKSLLKKHLTKEIFDALKTKKSGFGCSLLDVIQSGVENLDSGVGIYAPDAESYTLFGDLFDPIIDDYHGGFKKTDKHPPKDFGDVDTLGNLDPTGEYIVSTRVRCGRSLDGYPFNPCLTEAQYKEMEDKVSSTLSGLEGELKGTFYPLTGMSKEVQQKLIDDHFLFKEGDRFLQAANACRFWPTGRGIYHNDAKTFLVWCNEEDHLRIISMQMGGDLGQVYRRLVTAVNDIEKRLPFSHHDRFGFLTFCPTNLGTTIRASVHIKVPKLAANKAKLEEVAGKFNLQVRGTRGEHTEAEGGIYDISNKRRLGLTEYQAVKEMHDGIAELIKIEKEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MQQ5</accession>
    <name>A0A8J2MQQ5_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS11526</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5103471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MQQ5"/>
    <dbReference type="OrthoDB" id="8048189at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035217158" evidence="2">
        <location>
            <begin position="19"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="112"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5103471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="161" mass="18172" checksum="9D1970C751A614D1" modified="2022-05-25" version="1">MLKSLWIGIAFALIAVSAEPAIDNEEIAGDNFVEDAVVEDENNNYNGKDDFKNVDTNIPGFDKGLPTPEEFLEMLESMNLSDEEKANLQDAIMNNANMDQMLGRAPSAGKPFFSQLVVLLSLLSIVAVIFVFFGYKLYKSLIDKERKREMKKKLKEMKKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MQU6</accession>
    <name>A0A8J2MQU6_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similar to NMRK1: Nicotinamide riboside kinase 1 (Homo sapiens)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS10995</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5102398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MQU6"/>
    <dbReference type="OrthoDB" id="10041966at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02024">
        <property type="entry name" value="NRK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006083">
        <property type="entry name" value="PRK/URK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10285">
        <property type="entry name" value="URIDINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00485">
        <property type="entry name" value="PRK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phosphoribulokinase/uridine kinase" evidence="1">
        <location>
            <begin position="6"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5102398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="191" mass="22409" checksum="CCCAA8C6657F8142" modified="2022-05-25" version="1">MARWLIVGIGGATCSGKTTLSKKLHEFFKNSRLINQDSYFLPEDDPRHVHIPKLNHHNWDILTSLDTSRMYADVLKILSGSNRSLSGANTNSLNINKKIEDTRVLILDGFLIFNDKPIAELCNLKYFLTLTKQQCWERRQQRVYDPPDVPGYFDKVIWPEYEKHLEEIKREKKINFIDETFLSSIFLLQMY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MR04</accession>
    <name>A0A8J2MR04_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS11781</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5103981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MR04"/>
    <dbReference type="OrthoDB" id="7617315at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035210189" evidence="2">
        <location>
            <begin position="24"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="31"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5103981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="111" mass="12608" checksum="7A1D54426F54BC7B" modified="2022-05-25" version="1">MNDNTILFSSLLLDACIVPVSVPVCHLDSRQQQQQQQQQQQQQPQQQHQQQLQQQQQQQQHQQQNNPPHLAYQQANHHSYTTVTTSNQQGGPGVGVMAHQQGAAVFCIDLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MR46</accession>
    <name>A0A8J2MR46_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Serine/threonine-protein kinase SAK</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Serine/threonine-protein kinase Sak</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">HICCMSTLAB_LOCUS10859</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
            <location evidence="1">Centrosome</location>
            <location evidence="1">Centriole</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5102126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MR46"/>
    <dbReference type="OrthoDB" id="10004143at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005814">
        <property type="term" value="C:centriole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13114">
        <property type="entry name" value="POLO_box_Plk4_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13115">
        <property type="entry name" value="POLO_box_Plk4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000042">
        <property type="entry name" value="Aurora kinase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000571">
        <property type="entry name" value="Maternal embryonic leucine zipper kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.930">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1120.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1120.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047108">
        <property type="entry name" value="Plk4-like_POLO_box_2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033699">
        <property type="entry name" value="POLO_box_Plk4_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033698">
        <property type="entry name" value="POLO_box_Plk4_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046437">
        <property type="entry name" value="Ser_Thr-PK_POLO_box_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24345">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE PLK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24345:SF91">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE PLK4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18190">
        <property type="entry name" value="Plk4_PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18409">
        <property type="entry name" value="Plk4_PB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82615">
        <property type="entry name" value="Polo-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51984">
        <property type="entry name" value="CPB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51985">
        <property type="entry name" value="CPB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="6 16" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="15"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="Cryptic POLO box 1 (CPB1)" evidence="14">
        <location>
            <begin position="411"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="domain" description="Cryptic POLO box 2 (CPB2)" evidence="15">
        <location>
            <begin position="525"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="303"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="349"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="304"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="45"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CAG5102126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="769" mass="87886" checksum="633DD027D6203696" modified="2022-05-25" version="1">MPPMSEGFGDHIEDYTELEFIGRGGFGDVYKARCLNTGIDVAIKKINIKLMQDHGMIGRVREEVAIHSKLRHPSILKFYTSFKDAKYVYIVLELCPYGDLQRFLKKHYVQRLSENEAARIIKQVAEGLLYLHDRNMVHRDISPSNLLLTAEMQVKIADFGLAKLMKPNQNNMTMCGTPNYIAPEVATKSSHGPKADLWSLGCLLYTLLVGKAPFDSGGVRSTLALIAKGYYNLPSYLSDSAKDLISRLLQKEPHHRIELRDILKHSFITSIEKKYQEKMLMSRALSRDRMADSGLGKTMSSVDRMVRGRSRSEERASMLPSSYNPLAPHFTVRSDPVTDRNNCQNNFAYQNKRNDYSHEQTSVRSAGIPPSRSRVFSRTSHTSVDDINCQRNDKQKYREQAGDYLKDQDVNVKLQTPPLNSKRLLPTRHRTKNVILTILDNGEVCLEFIKRKNNNLERIGEVCRISSDGLQIILYKLRDSREIDDKPPPVPAHDADIYSYENLPSRHHRKYVYATRFVNLVKAKTPKITLYNERAKIHYMENGPRPDCEVHFYNGIKVTCVDKIIKITDLVGNSYKEGEIPGELEEYYKHYKKCYQYCLCLEASLNTLESATEESCFPVIIGRRPLSAGNVSSLQGKENVLRVINSPQTINNSPVMPSFDYSVMSGVTLKSKRTTSNRSIQYDYKKEYIPGIGNGIQLPNGDIKIEYEDGSTLTVFPKSQGNEILYERNNGMISKYSTNQHKKLQIPYEVQKKLRRDLPELSRAEIAYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MRJ6</accession>
    <name>A0A8J2MRJ6_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Similar to pum3: Pumilio homolog 3 (Danio rerio)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HICCMSTLAB_LOCUS11677</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5103773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MRJ6"/>
    <dbReference type="OrthoDB" id="497380at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012959">
        <property type="entry name" value="CPL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033133">
        <property type="entry name" value="PUM-HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040059">
        <property type="entry name" value="PUM3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001313">
        <property type="entry name" value="Pumilio_RNA-bd_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13389">
        <property type="entry name" value="PUMILIO HOMOLOG 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13389:SF0">
        <property type="entry name" value="PUMILIO HOMOLOG 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08144">
        <property type="entry name" value="CPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00025">
        <property type="entry name" value="Pumilio"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50303">
        <property type="entry name" value="PUM_HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="PUM-HD" evidence="4">
        <location>
            <begin position="103"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAG5103773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="621" mass="70755" checksum="60B90DB8ADA8BE92" modified="2022-05-25" version="1">MKRKETFDASAFVPKLKKKKENKIKEEPESGAAKPPGKPDKKSKFSKPSKPPSKFDKKGPKYESNTEESTEKPDWKVIKKERKELRAKRKSKKLENIYDISIEGKKIDEQMRRKDCPPEERTELCQKLFKLFEGNLVKLVFTHDISRVIQILIKYSSAEMLATVAAELKPSFLNMIQSKYARNCIKKFFKYGNDQIRSDIFAACEGHVVQLMSHSVAAPIMDYILYKKNKKDKNKKCWASEQVRSTFKQEFYGNMYRTSKDSSVKCLSDVFAKAPDMKSATLSAVKMNVTKILSKNPNCLLIHSVLAEYLTICEVNDRAELIGTLKESVVELLATKDGAKVAMICMWHATAKERKAMLKVMKEQIKEIATSEYGYLFLLAMLDSVDDTVLVKKIFVPEFLSHLQEIVASEHGKKVVLYLVARRDTHYFHPALISILSEGDNNLTSKKSPDIREKELLEAVIEPMLESIAGDVNSWLADGPVMLVTHAVLKAASGNEKLVDAWNAIADFLVNEESTLKHEEADIKAVEHPALHLVLKKLIVADKERVEREETSFGDLLVQKMSSDVIKRWVEYNRACFLIVLLLENERETVVRELKGKLKDLVKEIKSKKHKGADVLLKKIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MRK8</accession>
    <name>A0A8J2MRK8_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS11210</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5102840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MRK8"/>
    <dbReference type="OrthoDB" id="7452077at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5102840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="106" mass="12557" checksum="92A7ADD5E93603E6" modified="2022-05-25" version="1">MKNKSFINNDREFLPKEIGVTSLINGDTAHWILTPEFLFNLLSEERQLENNALTRKHGLEWYDGESMIKYVHTQLRYFCQNSMKIYTRGRAQKSYLESLLCRPVIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MRY9</accession>
    <name>A0A8J2MRY9_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transmembrane protein 242</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HICCMSTLAB_LOCUS12356</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Scaffold protein that participates in the c-ring assembly of mitochondrial ATP synthase (F(1)F(0) ATP synthase or complex V) by facilitating the membrane insertion and oligomer formation of the subunit c/ATP5MC3. Participates in the incorporation of the c-ring into vestigial complexes. Additionally influences the incorporation of subunits MT-ATP6, MT-ATP8, ATP5MJ, and ATP5MK in the ATP synthase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM242 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5106631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MRY9"/>
    <dbReference type="OrthoDB" id="2378895at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009792">
        <property type="entry name" value="TMEM242"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13141">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 242"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13141:SF4">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 242"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07096">
        <property type="entry name" value="DUF1358"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="75"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007570"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00045905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAG5106631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="177" mass="19799" checksum="47203B599A6729EC" modified="2022-05-25" version="1">MAASNKISSDQNFNMDNEFNKLSVKNDSGLSNNNKFYGFGTAVAGMRKQDPKYFQEGVVGVKGASEAGVSLAMRALGIGTVYAVTGCGLLFYGIWKLSGATNALEFRQKMGSFLPQIPKNNPPKSRTEFEGLNDLLKYVSEEWGKESTRFSFQIFMIANTRCLLFSWRTLFNMKYFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MTL7</accession>
    <name>A0A8J2MTL7_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS13644</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5109008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MTL7"/>
    <dbReference type="OrthoDB" id="7635559at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.220.10">
        <property type="entry name" value="Leucine Aminopeptidase, subunit E, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043472">
        <property type="entry name" value="Macro_dom-like"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5109008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="301" mass="33748" checksum="49BFB81102CD7138" modified="2022-05-25" version="1">MIRTRGEIITHIRKVEIKFHVVDDSFPIQQSGILGVEFLLCADDVPIADSDTSQTHHINLVNKDEDNTNVESLVASIFQLNSPNDNNYSCNMCFNLPPTNFPDFDGTGVTNNTRYGSQADPERTQGQEVNFAHDTLQVSGGDKLQDLVALGPLDETLIRSIFINTPSYVTTTRDKISMRKDNLVHFTSVDGTFLPETSRDLLNQSKFSVREIINNAEEPGTAIASRWNDHFVFHLIIKRTSDDRINPKDIENTVLSLRNLLVHLQVKTVSIPQRKNNGLSNAEWKKAVTIGNTFLGKEGRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MUA5</accession>
    <name>A0A8J2MUA5_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HICCMSTLAB_LOCUS13311</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5108586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MUA5"/>
    <dbReference type="OrthoDB" id="6278121at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd23599">
        <property type="entry name" value="TFP_LU_ECD_Cold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.60.10">
        <property type="entry name" value="CD59"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045860">
        <property type="entry name" value="Snake_toxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10036">
        <property type="entry name" value="CD59 GLYCOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57302">
        <property type="entry name" value="Snake toxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035182444" evidence="3">
        <location>
            <begin position="21"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG5108586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="143" mass="16602" checksum="CBD5CABDDC2B4C97" modified="2022-05-25" version="1">MKQKFITLLLIISSLSLGNALECYVCDNQEGNKEKCLNSIRNCEHEEDSCYTEVRWGSLPYWSEGAPKQYYISKRCMPHKKCLEQKQKNMKDCTYVWYQDWKCSDCCRGDRCNYFIFSSAKSHSISISCLLTTVLSGLYGVLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MV01</accession>
    <name>A0A8J2MV01_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS8488</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5096993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MV01"/>
    <dbReference type="OrthoDB" id="6159439at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5096993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="146" mass="16846" checksum="06FB1042988F578F" modified="2022-05-25" version="1">MPSHRYINVSEFYPTARSRHAVPSSVWFQNRRAKFRRNERSRGASSTRDIETTLPLRPIRIAYTHENTPETLQSPPQVPQYSYSEYWRSSQNYGFVNGNLNNVSFPSYHQSEVHGSIEGTSMNSLSNLRLRSHPYSASYSAMHASM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MVA3</accession>
    <name>A0A8J2MVA3_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Secretory carrier-associated membrane protein</fullName>
            <shortName evidence="5">Secretory carrier membrane protein</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HICCMSTLAB_LOCUS13996</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Membrane</location>
            <topology evidence="1 5">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SCAMP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001140">
        <property type="protein sequence ID" value="CAG5109360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MVA3"/>
    <dbReference type="OrthoDB" id="242866at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055038">
        <property type="term" value="C:recycling endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032588">
        <property type="term" value="C:trans-Golgi network membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007273">
        <property type="entry name" value="SCAMP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10687:SF2">
        <property type="entry name" value="SECRETORY CARRIER-ASSOCIATED MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10687">
        <property type="entry name" value="SECRETORY CARRIER-ASSOCIATED MEMBRANE PROTEIN SCAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04144">
        <property type="entry name" value="SCAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="26"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="50"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAG5109360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="164" mass="18983" checksum="6E63480D94280A6D" modified="2022-05-25" version="1" fragment="single">VRRAANTAPASRGIEDYNPFADPVPGQNNNNQTQQVRGASNPPMYGGVGATPTPATLQPTQEIPPPNYTRRNNWPPLPEKCCFQPCFYQDIDVDIHTDFQRVVRQLYYLWISWTCIIIKCDRWFRFNAVLQRVRNIRSRYSLPHTIYTVFIRLLVQASLQSVQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MVC1</accession>
    <name>A0A8J2MVC1_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Membrane-associated (Monodelphis domestica)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS14026</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001346">
        <property type="protein sequence ID" value="CAG5109390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MVC1"/>
    <dbReference type="OrthoDB" id="10265800at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004620">
        <property type="term" value="F:phospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006644">
        <property type="term" value="P:phospholipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038885">
        <property type="entry name" value="PLB1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21325:SF31">
        <property type="entry name" value="GH22081P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21325">
        <property type="entry name" value="PHOSPHOLIPASE B, PLB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5109390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="102" mass="10890" checksum="4730451FDD769377" modified="2022-05-25" version="1" fragment="single">MLSLSLSPIPPDSVHKLRPGDIDVIGGLGDSLVAASGALEEFAIGTFIEARGAKLNVAFPVAATEDALHQAKILIKRIKSNSKIDIKKHWKLVTIFFGANDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MVD3</accession>
    <name>A0A8J2MVD3_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Isoforms A/B/D/L (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HICCMSTLAB_LOCUS14058</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001579">
        <property type="protein sequence ID" value="CAG5109895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MVD3"/>
    <dbReference type="OrthoDB" id="10004641at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13909">
        <property type="entry name" value="zf-H2C2_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="23"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG5109895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="77" mass="8762" checksum="95E081D3D4030A14" modified="2022-05-25" version="1" fragment="single">MWRSGGGLGKGFAGSATGNPEGFNCPACGRVYKLKSSLRNHQKWECGKEPQFQCPHCVYRAKQKMHIARHMERMHKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MW55</accession>
    <name>A0A8J2MW55_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to C18orf63: Uncharacterized protein C18orf63 (Homo sapiens)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS9533</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5100397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MW55"/>
    <dbReference type="OrthoDB" id="6285995at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031643">
        <property type="entry name" value="DUF4708"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28495:SF1">
        <property type="entry name" value="GENE, 17266-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28495">
        <property type="entry name" value="HYPOTHETICAL PROTEIN LOC100359752"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15813">
        <property type="entry name" value="DUF4708"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4708" evidence="2">
        <location>
            <begin position="14"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="465"/>
            <end position="507"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF15813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5100397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="507" mass="57542" checksum="E29A5A3DE133C955" modified="2022-05-25" version="1">MDENEFVIPVTARKSLCCIVCTVDCDDIKLSSAKSSWHWQKLKCRLLIYLLKDNFIVGSPIPRSNTSFYIIVTNDFYKSDTLTNIIKKLNLHASEPQPVTARAYITCIRYTIDFYLSPEWNKVATLYFQGDDFWKSTERSTAVQAIINLITPERSDVDKIAIILTPVKAKLPSLRLNDFCIPHSVISDFLADPNGVIDVSLFGNERVAVLPSLKLGKVLRIMKNIPSTCPYQNWTEMRRFWKNMYGYRLPKTSEGILFYDIKFPSLTPNDRFIYPDICIRSGLQQYSYGAGAEAVVKNFMTHLTTSMPKMCIDKLIDQNLMQITHQVDETTTEMKTPVNQQEHSCLVKSRKLSAPTLLKDCNIASKSDTKSTLTELKINEEASDVKYSEPKSATIANNRQLTNSMSPTKSLLRKPVEARPLNYDNLKNIEQLYQPITQTQRPRINIFKNASRFFTDDSKEARMRQAASVFSSGLGGDSNEDARRVSSKPNDELLGESDGNGDFTGLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MWZ5</accession>
    <name>A0A8J2MWZ5_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Olfactory receptor 189</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HICCMSTLAB_LOCUS11008</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5102424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MWZ5"/>
    <dbReference type="OrthoDB" id="6597368at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005549">
        <property type="term" value="F:odorant binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004984">
        <property type="term" value="F:olfactory receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004117">
        <property type="entry name" value="7tm6_olfct_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21137">
        <property type="entry name" value="ODORANT RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21137:SF35">
        <property type="entry name" value="ODORANT RECEPTOR 19A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02949">
        <property type="entry name" value="7tm_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0552">Olfaction</keyword>
    <keyword evidence="8 11" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="9" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="68"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="97"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAG5102424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="180" mass="20261" checksum="0C3C372BE6029806" modified="2022-05-25" version="1" fragment="single">MPPAPVTAATVVQLLATLCPGFFKNIKIYLPILVLNIKAVKITEKKLFADCVEYHIDILKMVETMSRVFGPMIFIQYSFSSIILCSSVYALSQMVPFSPEFIACLVYILCMFFQIFVICLSGNQVSLEFAELGPEMYNTNWFLLSINAQKHVAMMMMSSVKPIIFSCGHVATLSLESFKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MXJ9</accession>
    <name>A0A8J2MXJ9_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ZP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS10740</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5101888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MXJ9"/>
    <dbReference type="OrthoDB" id="10310055at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035230394" description="ZP domain-containing protein" evidence="1">
        <location>
            <begin position="22"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5101888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="124" mass="14022" checksum="20D985FC86143016" modified="2022-05-25" version="1">MVSYQITAFISLALVYTCSNALRFEAPKCIIHSYCGKDNAIVKLVPLKPFNGLIGTDVESPECKRRFTSNEKSITFVVDFENCTLESDKFKLNVYNPMMLTKDFGFLGPPVISKQVFCKQADYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MXM8</accession>
    <name>A0A8J2MXM8_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS10845</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5102098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MXM8"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5102098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="120" mass="13751" checksum="3A709F3FB9599924" modified="2022-05-25" version="1">MKNYQQVKFIILIISVLFSFANARIIHLSAYEKLKFQCSSTSVKIFFSTRRSYSTSLIVNSPDQNCVKSSGISEQIRFKFDLNQCTSGAKKFNLTVIEISQNKNKFPFTNEVEIDCQKST</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MYD6</accession>
    <name>A0A8J2MYD6_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Similar to Tret1: Facilitated trehalose transporter Tret1 (Bombyx mori)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HICCMSTLAB_LOCUS12778</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5107507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MYD6"/>
    <dbReference type="OrthoDB" id="6133115at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000218">
        <property type="entry name" value="facilitated trehalose transporter Tret1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050549">
        <property type="entry name" value="MFS_Trehalose_Transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48021">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48021:SF1">
        <property type="entry name" value="GH07001P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="118"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="151"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="175"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="260"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="293"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="325"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="357"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="391"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="426"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="25"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAG5107507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="489" mass="54173" checksum="9CC35B4872B5FCC7" modified="2022-05-25" version="1">MTNQSPQLPNHRFGLWPQWLAALELLLMSMMVGLISGWTSPYLAKLDSIENPDSELPINKVEASWIASLINLSRPGGAILGAIFVYVIGSRLTTLLAGIPFALGWASFLIMNSVTLVYVSRTLCGIGLGMYYSSFPLYVGEISHPRIRGALVALIMQGLMLGNLCGTIMGKYLDMWLFASISLIPNLIFLGSFSLMPQTPHYLVRSNKMEEAAKSIRFYNRNADVTNELDALKQFMETNKALTLRDTWQALNTPLNRKTLLMVNIIFAFVQLSGLYTISAYMEIMLTKANVNIIKPSTLVISVSIISIASSWIATYTNDKCGRKIMLLLSSIGVASGMFLWGLNYQLLDLGYENPNLQWMSIIAAIVYQFSLAIGLMPVPTTFISEMFAPSVKGIGACISSGISGVFAFAASRSYQPMVDVLTEKYVFWIYGLLMITTGIYTMIFIPETKGKSLAEIQEILSQGIKSKSNNHSNKSKVYEENFKITDKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MZD9</accession>
    <name>A0A8J2MZD9_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Similar to HSDL1: Inactive hydroxysteroid dehydrogenase-like protein 1 (Homo sapiens)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HICCMSTLAB_LOCUS12691</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the short-chain dehydrogenases/reductases (SDR) family. 17-beta-HSD 3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5107322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MZD9"/>
    <dbReference type="OrthoDB" id="5545019at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05356">
        <property type="entry name" value="17beta-HSD1_like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000137">
        <property type="entry name" value="Hydroxysteroid (17-beta) dehydrogenase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052149">
        <property type="entry name" value="17-beta-HSD3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44889">
        <property type="entry name" value="INACTIVE HYDROXYSTEROID DEHYDROGENASE-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44889:SF1">
        <property type="entry name" value="INACTIVE HYDROXYSTEROID DEHYDROGENASE-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000126">
        <property type="entry name" value="11-beta-HSD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035167842" evidence="6">
        <location>
            <begin position="26"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAG5107322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="315" mass="35275" checksum="DA748686044ACD90" modified="2022-05-25" version="1">MILSISLWLLVAVLILWILLDPVSRISRAIFEVLIPLVNQKPIDLKNKFGEWAVVTGSTDGIGKAYAKELANRGFNLVLISRNAERLEKTKSEMLTISPNIQIKLISADFSKGRDVSVEIEPHLRDIPVGILVNNVGKQYTYPMYVGEVPEDELWDIINVNIGAATLMTRIVIPGMQKRQRGAIVNVSSGSELQPLPLMTVYAATKVYLRSFSEALRVEYNKFGITVQHLTPLFVNTKMNAFSHRLQVSTVAVPDATTYAKNAVATLGKIDSSTGYWAHGIQAFFTLIPPVWIRTKIGEMMNQTFRKDYLKQKNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-10-16" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>S6D4V0</accession>
    <name>S6D4V0_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Cc_bv12.1_17.5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">bv12-1</name>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS1887</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Philos. Trans. R. Soc. Lond., B, Biol. Sci." volume="368" first="20130047" last="20130047">
            <title>Functional endogenous viral elements in the genome of the parasitoid wasp Cotesia congregata: insights into the evolutionary dynamics of bracoviruses.</title>
            <authorList>
                <person name="Bezier A."/>
                <person name="Louis F."/>
                <person name="Jancek S."/>
                <person name="Periquet G."/>
                <person name="Theze J."/>
                <person name="Gyapay G."/>
                <person name="Musset K."/>
                <person name="Lesobre J."/>
                <person name="Lenoble P."/>
                <person name="Dupuy C."/>
                <person name="Gundersen-Rindal D."/>
                <person name="Herniou E.A.Drezen.J.M."/>
            </authorList>
            <dbReference type="PubMed" id="23938757"/>
            <dbReference type="DOI" id="10.1098/rstb.2013.0047"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CAJNRD030001116">
        <property type="protein sequence ID" value="CAG5075839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="HF586474">
        <property type="protein sequence ID" value="CCQ71292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S6D4V0"/>
    <dbReference type="OrthoDB" id="10445618at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5075839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCQ71292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="207" mass="23465" checksum="7299BEEEDE0D087E" modified="2013-10-16" version="1">MSEYQLLTSEIMVPKEWPIKTAKNLITNIAKQAISNHQKGVKISLTVSDVTGLVIDNENGPGYIFKKIEEIHEDTGRIDLLIPVRTDIIMPEPNLLAPTGSHRSEIVSIDVRYDHPISRMLVPKSDRHVVLIAAPIIEEVLEKKGVRGYEMYDYTLRSTYTINNKSYNDVLKQKLSSSSQSGHPSISIERIGTDKWIIVYNDRLSQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2E5D7</accession>
    <name>A0A8J2E5D7_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Aminopeptidase N</fullName>
            <ecNumber evidence="5">3.4.11.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="23">Microsomal aminopeptidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="30" type="ORF">HICCMSTLAB_LOCUS716</name>
    </gene>
    <organism evidence="30 31">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="30" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of an N-terminal amino acid, Xaa-|-Yaa- from a peptide, amide or arylamide. Xaa is preferably Ala, but may be most amino acids including Pro (slow action). When a terminal hydrophobic residue is followed by a prolyl residue, the two may be released as an intact Xaa-Pro dipeptide.</text>
            <dbReference type="EC" id="3.4.11.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="25">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="25">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the peptidase M1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="30">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.2" evidence="5"/>
    <dbReference type="EMBL" id="CAJNRD030001114">
        <property type="protein sequence ID" value="CAG5073944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10031169at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016285">
        <property type="term" value="F:alanyl aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042277">
        <property type="term" value="F:peptide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043171">
        <property type="term" value="P:peptide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09601">
        <property type="entry name" value="M1_APN-Q_like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.390.10:FF:000019">
        <property type="entry name" value="Aminopeptidase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.50.20:FF:000001">
        <property type="entry name" value="Aminopeptidase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1910:FF:000008">
        <property type="entry name" value="Aminopeptidase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.390.10:FF:000013">
        <property type="entry name" value="Aminopeptidase N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1730:FF:000012">
        <property type="entry name" value="Aminopeptidase N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.50.20">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1910">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="entry name" value="Neutral Protease Domain 2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1730">
        <property type="entry name" value="tricorn interacting facor f3 domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045357">
        <property type="entry name" value="Aminopeptidase_N-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042097">
        <property type="entry name" value="Aminopeptidase_N-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024571">
        <property type="entry name" value="ERAP1-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034016">
        <property type="entry name" value="M1_APN-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001930">
        <property type="entry name" value="Peptidase_M1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050344">
        <property type="entry name" value="Peptidase_M1_aminopeptidases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014782">
        <property type="entry name" value="Peptidase_M1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11533:SF290">
        <property type="entry name" value="AMINOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11533">
        <property type="entry name" value="PROTEASE M1 ZINC METALLOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11838">
        <property type="entry name" value="ERAP1_C"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01433">
        <property type="entry name" value="Peptidase_M1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17900">
        <property type="entry name" value="Peptidase_M1_N"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00756">
        <property type="entry name" value="ALADIPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63737">
        <property type="entry name" value="Leukotriene A4 hydrolase N-terminal domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 30" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="20" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="21" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="22" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="19" id="KW-0472">Membrane</keyword>
    <keyword evidence="12 25" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="10" id="KW-0645">Protease</keyword>
    <keyword evidence="31" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0732">Signal</keyword>
    <keyword evidence="16" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="15 25" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Aminopeptidase N-like N-terminal" evidence="29">
        <location>
            <begin position="7"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M1 membrane alanine aminopeptidase" evidence="27">
        <location>
            <begin position="141"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="domain" description="ERAP1-like C-terminal" evidence="28">
        <location>
            <begin position="441"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="domain" description="Aminopeptidase N-like N-terminal" evidence="29">
        <location>
            <begin position="874"/>
            <end position="947"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M1 membrane alanine aminopeptidase" evidence="27">
        <location>
            <begin position="982"/>
            <end position="1067"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M1 membrane alanine aminopeptidase" evidence="27">
        <location>
            <begin position="1069"/>
            <end position="1182"/>
        </location>
    </feature>
    <feature type="domain" description="ERAP1-like C-terminal" evidence="28">
        <location>
            <begin position="1260"/>
            <end position="1576"/>
        </location>
    </feature>
    <feature type="domain" description="Aminopeptidase N-like N-terminal" evidence="29">
        <location>
            <begin position="1617"/>
            <end position="1804"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M1 membrane alanine aminopeptidase" evidence="27">
        <location>
            <begin position="1837"/>
            <end position="2059"/>
        </location>
    </feature>
    <feature type="domain" description="ERAP1-like C-terminal" evidence="28">
        <location>
            <begin position="2136"/>
            <end position="2456"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="24">
        <location>
            <position position="1909"/>
        </location>
    </feature>
    <feature type="binding site" evidence="25">
        <location>
            <position position="1908"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="25">
        <location>
            <position position="1912"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="25">
        <location>
            <position position="1931"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="26">
        <location>
            <position position="1994"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00015611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00042613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="PIRSR" id="PIRSR634016-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="PIRSR" id="PIRSR634016-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="PIRSR" id="PIRSR634016-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="27">
        <source>
            <dbReference type="Pfam" id="PF01433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="28">
        <source>
            <dbReference type="Pfam" id="PF11838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="29">
        <source>
            <dbReference type="Pfam" id="PF17900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="30">
        <source>
            <dbReference type="EMBL" id="CAG5073944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="31">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="2515" mass="289700" checksum="989F495A93EBDD17" modified="2022-05-25" version="1">MPVNSTTVIQITYNGIIRDDMIGFYRSSYFSETGDIKWLAATQFQTTHARHAFPCFDEPNLKANFTIIIRRPKSYTSLSNMPLKRTVTITDELQSDTYESSIPMSTYLVAFVVTPDFKSNRDEENNITIWTQPLAVNLTNYALKVGYHALNYFTSLFNESYQIEKMDMIAVPDFSAGAMENWGLITYRENYLLYDVTESSDSAQQKVASTIVHECAHMWFGNLVTPEWWGYLWLSEGFANYYQYFVTSLIEPDWAMDQQYIVDHLQSVLQNDGLESSKPMTRQVNSTSDISTTGDTITYSKGGSILRMMNLVLGSDIFNSAIQNYIKTKKYQSATPNDLWKSFQQQLDSSNKSLPASVETIMTSWTSQSGYPIVTVTIQNNTAQLRQERFSIRNESADDNSTWWIPLTWSTKSEHNFEITSSRYWLSEKNSVIKLNTSDEWIIFNIKQSGFYRINYDQQTWDRIINLLNSDSFKEISVINRAAIIDDLLNLARAGLIDYSTALSGLKYLRKETEYLPFKSALTGLEYLHKRFIGQENYQLFAEFILNLISPMYNRLNFKDDINDDRLTVLLRAELNKWACELDYKKCVDKSLNYFTDWMKNSSKTIPKNSKNIVFCTAARLSSTGNTDLIPEYTLDKLLSNFTIETPMILEAQACSRNNTVLKRVSKIILEGFESSKVRKQDGIYFFRSVAQSSPFGAEYILEFINDHYDELLDYLGNINSIADIISLASQQFSSKNLVNKLETFITNNSIILDPIIDSLNSSLKLSQFELNFYEKNSPLIIPWIEEYNTKLNGNSGEKSNEYRLPTNIVPKKYTVKLTPFIEPGNFTFKGYVEIIAYIVNSTNKVVLHIDDINYETVALSVDDKQIKVNSTAEDKKWLAATHLEPVGARRVFPCFDEPGLKATFELSVSRPADYKAISNTLLKSTVKDGDRYIDTFEPTPNMSTYLVALIVSDFNSISHDKLFSSWARPNAIIQANYSSSIIKPIVNFFEKALGHSYQLPKLDMIALPDFASGAMENWGLITYRETNMLYHPDYSPITSKQAIANVVAHEIAHQWFGNLVSPHWWSYIEPSWGLEFQFVVEQLQTSFSADSFPSSHPMSHNVNSPAEISNIFDTISYSKAGSILRMIEKNFGSNLFYAALNDYLGMRNYSDAIPEHLFTAFQKQTDKANMNLNITTILNSWTTQPGFPVVNVKIFNQTVTLSQEQFLLQNPDNISVNKTWWIPISWTSNENSDFNSTITKYWFYKSNDSVKINTTSAKWIIFNVQQSGYYRVNYDTDSWSHITQALKSSEFEKIHEINRASILDDALNLARAGYLDYSIALNITQYLTQEVNYIPWRAAFNNLLFLHQKFVGTNIYDLFKTHILTILDPVYNKLSFNENHNNDTHYDKLLRRYIINWACELGVEDCIKNSIALFSRWKSSNTQLVPVNLRSTVYCTAIKYGTDEDWEFLWNKYQTVNFAHEKVVISSALGCSKNKNKLDKLLSSAISKNSGIGSQDSLTVFASVYSSGLFGAEHALNFVDKYYDAMLNYYGKHDTIAAILNDISSQFSTKDLVEKFKNFISSKKKNLSAIEESLKSYLSRAYKELDWYNNYSPQIFEWLDKTYPNSDYRLSKNIYPSSYKIYLTPYFDNFTFDGRVEINISVMQNTSSIVLHANNLTIKEISVSENSLEGNSLTVSSYLINSTTHKFTIYLSSTVNDGSNLTVNVEYTGILNDKMEGFYRSYYKDDNGISHWLATTQFEKFGARQAFPCFDEPIFKAKYKIHIQRLNNYHSLSNMPLNISLPSEKFNWTWDYYEESVPMSSYLVAFIISDFESYPNFHENFTVWSRPNAVQYTSHALDFGQKALQFLENYTGISYPIKKMDLVAIPDFAAGAMENWGLVTFREYGLLSKENITTTYYMRYLNTVIAHELVHMWFGNLVTCDWWEYLWLNEGFAQYLEWIVTDSIFPEAQLMKQFSVYEIQPALLKDSYIHMRPMNNKMKNPYDDGKDFTSIVYGKAASVIHMIKYAVGEDIFKKSLHNYLDNNKFNTSKPEYLWSALQMNINQTTGINETIFTLMDSWASQAGHPVVHAHVTAGSLFLEQVRFLISGRNNSAKELYWIPITITSKSSANFSHTSPTLWFGTRGTTTDKFNLTDEWFIINVNQVGFYRVNYDTNNWNYLIDALISEDNFGGIPEINRAQIIDDLLILARADYVEYEIALRATTYLIKEKNHLPWKSFLNSVQFLIERFDGNQKITSSLKEYVLKLIEPIYEELGFEDKANDTDLDKLNRQIILFWTCRFGHAKCIEKAKQIFDAWRVNETYFIFPNAKPAVWCTALKHGDFDDWELMWQEYRASNFESEKVMILSALGCSQNSTAIKKYLTHAVSSDGSIRDQNFVNVFSSVYSAEKYGVDLSIEFFINNYTSIYKFYKKWGSVADLFSNIVSKVSTEEQIQKLISFVMEHEEEFEEIRSTLDESIINARMMLNWSQFHYGKILDWLTNENSIESWGSRYSSSGTANAIEPLSLIIILISSVILL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2E5X0</accession>
    <name>A0A8J2E5X0_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to nrf-6: Nose resistant to fluoxetine protein 6 (Caenorhabditis elegans)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS1019</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001114">
        <property type="protein sequence ID" value="CAG5074322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2E5X0"/>
    <dbReference type="OrthoDB" id="207378at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002656">
        <property type="entry name" value="Acyl_transf_3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006621">
        <property type="entry name" value="Nose-resist-to-fluoxetine_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052728">
        <property type="entry name" value="O2_lipid_transport_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11161">
        <property type="entry name" value="O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11161:SF0">
        <property type="entry name" value="O-ACYLTRANSFERASE LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01757">
        <property type="entry name" value="Acyl_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20146">
        <property type="entry name" value="NRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00703">
        <property type="entry name" value="NRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="125"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="181"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="228"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="270"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="360"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="403"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="437"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="520"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="domain" description="Nose resistant-to-fluoxetine protein N-terminal" evidence="2">
        <location>
            <begin position="1"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5074322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="587" mass="67364" checksum="F6AEA3A9AF9E8A4F" modified="2022-05-25" version="1">MAPLSFRLLVFDASTKLPSGIFEGNIRDLGMYDQCIKVNATVGNETIRGKHCIFSLKGNFNVTTLPIDPIMSVCLPATCSPKQVKEKMQKLFNMAEQFLGGREIRVNNTICSEVDAQPWELGAKVTLGVFVGLVTFLLICTFCELLPKFTSINSGLITTLSKFSFIVNGQRILSTKVSKENIPGIAGLKVFSMFWIIFVHAYIHSLSCSMINLGEVESWYYSWRSTHVFVATYSLDTFLAVTGFLTSYLFLKEMAKRRKFNVFMYYLHRYIRLTPAYGALLLFTIYLIPKMSSGALWQPAFNNQSTSCKQDWLPMILYGYNFYYVQGMTCLVHTWYLAMDMQLFWVSPFILYPLYKKPKLGLIILSAAIVASVITPATVVMVNKFSTMISKEQYTDIRMMLKYYVVPYCRAGPWLLGILTGYLIASGSKPPSSGVRIIGWILTFLAFTYGYFTFRIYQQEDYKWNMYWEMFHGIVTKFLSHPIYLPFSRVSYSIYLLHLIIQSIRVYSMRTPIYFSEYQMIIIIIIDVITSFLAAIIFSLVFESPFVILEKLIFSREKPIDRPPEPIQEEITSENGIINHGFGKQVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2E9C1</accession>
    <name>A0A8J2E9C1_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SAM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS760</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001114">
        <property type="protein sequence ID" value="CAG5073988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2E9C1"/>
    <dbReference type="OrthoDB" id="7760234at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09487">
        <property type="entry name" value="SAM_superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00536">
        <property type="entry name" value="SAM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAM" evidence="1">
        <location>
            <begin position="3"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5073988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="190" mass="20487" checksum="5CE7C3A1DCAD4F39" modified="2022-05-25" version="1" fragment="single">EDIDGAAFLQLTNQDLSQLKIKMGPKKKLLALIDSLNQEKITGSYIIIDSSGVLEKQTQNETVCSTLPINVSLSRASTSGVTSSLSSPKPTPASCTLSTSVVSSNTFSRYGTVENTLKEHQQGKEILSAIRGITCSEGDRKCFVRILVGELVKTHNDSCYPPKEAKIALAKAISLKNSQNLKIRSNLMAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2EFD7</accession>
    <name>A0A8J2EFD7_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BEN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS433</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001114">
        <property type="protein sequence ID" value="CAG5073490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2EFD7"/>
    <dbReference type="OrthoDB" id="7701352at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2590">
        <property type="entry name" value="BEN domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018379">
        <property type="entry name" value="BEN_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10523">
        <property type="entry name" value="BEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51457">
        <property type="entry name" value="BEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BEN" evidence="2">
        <location>
            <begin position="130"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5073490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="234" mass="26261" checksum="52BB12A000C0A651" modified="2022-05-25" version="1" fragment="single">DNLSRRKILSDNELLDKQNQATTTKIVDAFGSLSTPITTANLQQNQQRVSSADGPNQSAESSGINDFDISGIRPRQSDDYSSRISLKEIYNDNKIIKKALLELTENVKILSAQRNATEENDEMVEIGNKGSGIFITKVQWDTAKSKSTYNSMGTALVMAMFPIDVLLKNNLRGGKSKFKFSTEQRVGLDKNIMDAIRVTVKKQHPQSYQRGFLGQSINNFLNDLRRKHKVDNCE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2EFH7</accession>
    <name>A0A8J2EFH7_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="6">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HICCMSTLAB_LOCUS508</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="6"/>
    <dbReference type="EMBL" id="CAJNRD030001114">
        <property type="protein sequence ID" value="CAG5073583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2EFH7"/>
    <dbReference type="OrthoDB" id="19653at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43142">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43142:SF1">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0719">Serine esterase</keyword>
    <feature type="domain" description="Carboxylesterase type B" evidence="7">
        <location>
            <begin position="2"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG5073583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="472" mass="53200" checksum="05A379C5CBA78034" modified="2022-05-25" version="1" fragment="single">MLRFSETVLGRFQWSGIREAKTYASKCAQVDLFTRKVMGAEDCLYLNVFTTNLNCKPVMVWIHGGAFFCGAGDDDFFGPDYLIEKDIVLVTINYRLGILGFLNLDDEEASGNQGLKDQVMALKWVQQNIAQFGGDPNNVTIFGESAGGASVHYLNLSPLARGFFDKFVLSGLFHKSIIQSGVATNPWAFTIHSPKEAAVKISSVLGNKTTDTQELIKYLRTVDVIELAKAEHEIKSMKEALMFENPFVPSVDLKSKTPFLTIPVHEAAKSGIKLPHMIGYTSQEGIFILSLNFFDFMKDDDYSKIEDNLNTLLLHEHMKNFLQERKISAGDVKKFFLGDKKISRENAPLVADLFSATLILINIHHALEAQHDAPTYLYKFDYYSKETAAMQKLLDIDVEGTCHAEDLIYLFRSKLLEEAGIKQIVPGTTEHVIRQQFLELWTNFAKTGNPNSETSELINVEWKPLDSFNEYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2EG38</accession>
    <name>A0A8J2EG38_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to Xpc: DNA repair protein complementing XP-C cells homolog (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS901</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001114">
        <property type="protein sequence ID" value="CAG5074129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2EG38"/>
    <dbReference type="OrthoDB" id="300780at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000111">
        <property type="term" value="C:nucleotide-excision repair factor 2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071942">
        <property type="term" value="C:XPC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.20.110">
        <property type="entry name" value="Rad4, beta-hairpin domain BHD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.260.10">
        <property type="entry name" value="Transglutaminase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004583">
        <property type="entry name" value="DNA_repair_Rad4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018325">
        <property type="entry name" value="Rad4/PNGase_transGLS-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018326">
        <property type="entry name" value="Rad4_beta-hairpin_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036985">
        <property type="entry name" value="Transglutaminase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12135:SF0">
        <property type="entry name" value="DNA REPAIR PROTEIN COMPLEMENTING XP-C CELLS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12135">
        <property type="entry name" value="DNA REPAIR PROTEIN XP-C / RAD4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10403">
        <property type="entry name" value="BHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03835">
        <property type="entry name" value="Rad4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01030">
        <property type="entry name" value="BHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rad4 beta-hairpin" evidence="2">
        <location>
            <begin position="678"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="113"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="284"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="26"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="284"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="325"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="350"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="363"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="507"/>
            <end position="531"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5074129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="785" mass="89085" checksum="BAB0BD392DE67530" modified="2022-05-25" version="1">MSSSDESSDSTEYLVPSSKIDLSSSFFSTTASTSKSNPKVRARIESSSSSEDDELPESSASNAELLLEVMKNLEKINNPVVQPSRAPAPVPESSSRELSSEIADLLLKHESGLGSFKLPDNEEEEIPKEQKQEKEQVQVQHPDYEVPQEGVNITLPGTGMPSFKRKKNKVGLLCWLAHGIHLNKQINDPEVMSTVLSLIPSISYPKGRVDIKYIEQFTKWFRGVIKVEFNKENVPVTKELLLKRLGEKKVRNYRELVLLYIAALRAIGCNCRLVLSLCPPPMKPKSDQLIKSKKEGEGTKERGGAKDKEPGRGKKSGEGEDKEDKDDIRNTMAKKWSEKNKGRGRGRKGGVSSVVGLVSNSKVADKMAKEEAKKKAAELLREKFASSKERGVKKLKRNDEGGKKEEGGVEEEEGKRLRSGDKKEEGVVKEEKGKRLRSGKSEDKKEEGIIKEEKGKRLRSGDKKVEEVVKEEKGKRLRRGRSEDKIVKKRRSEEMVEKGKGTLSSVGKEENEEKEEKMETESESENSEKEFKVKKKLGVGRKNLEAVKEERRLSEKRRKVLSSDDEEDIVDVRDSRYLWAEVYVEDEESWISVSVPDNKVHCVAEIFKKAPSPVLYVVAWNSLGKLKDVTRRYCRHWLTVTRKQRIDQEWWTETLSPWIESNSVMSRAEDEALLTMELEQPLPDRTADYKGHPLYALARHLLKYEALYPPDCQPLGYLKNGEAIYSRHCVHTLRSRETWLREARVVNLAKLNSEVVFNSFLTNLSIRFDKNNQVNTNSTTGQILA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2EGR7</accession>
    <name>A0A8J2EGR7_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Venom protein 24</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS1306</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001116">
        <property type="protein sequence ID" value="CAG5075152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2EGR7"/>
    <dbReference type="OrthoDB" id="7697653at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051057">
        <property type="entry name" value="PI-PLC_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13593">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13593:SF113">
        <property type="entry name" value="SI:DKEY-266F7.9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035321535" evidence="1">
        <location>
            <begin position="26"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5075152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="327" mass="37001" checksum="B4FEEF1DA9064C3F" modified="2022-05-25" version="1">MALHFVKKLLISIVVTTYLISDVEACIGVKCPDYISKYKKNVPRKRVISHLSDSLELRKLALIGTRYSASHVTGIPRYKTQKLTISQQLIFGVRVLDSAIWSSSNIFYLYKWAKYLMTFDEFLGPINSFLTANPGEFVITLIHEEHKRGSDVTKSNCEIVRSYCSLSNGHRIVTNWSLEDTIEQHRGKILLAGLDSSFDDCALSIASNGQVQNTETSVDSSSKIEDKWIDIQKFHDRSYRKDSGHCFVNFMADKADTNTWKMAVKGGTSTRNGCEAPLNVRMASYFSNPHRALIMVMADYVTQDFIDSILGTNFEGDSFYTNYTDDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2EI09</accession>
    <name>A0A8J2EI09_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Similar to tspan31: Tetraspanin-31 (Danio rerio)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HICCMSTLAB_LOCUS2126</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001116">
        <property type="protein sequence ID" value="CAG5076145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2EI09"/>
    <dbReference type="OrthoDB" id="5845060at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018499">
        <property type="entry name" value="Tetraspanin/Peripherin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19282:SF452">
        <property type="entry name" value="LD03691P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19282">
        <property type="entry name" value="TETRASPANIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00335">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00259">
        <property type="entry name" value="TMFOUR"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="44"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="74"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAG5076145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="169" mass="18202" checksum="F08F19458E184E7C" modified="2022-05-25" version="1">MCGGFTCSKNALTALNILYIVVAFILIGVAVYGRASALVTNLPIIGGILACGVILILISILGLIGAVKHHQVLLFFYMLILFLLFLVQFSIACACLAVNAKQQEQLAEQGWKRVGMELKSKVQTNFNCCGFNGTDIIDIDPKMHPSLLLMKNTAGSAKVVTFSHTGLEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2EJR3</accession>
    <name>A0A8J2EJR3_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="20">Ionotropic receptor 25a.1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">HICCMSTLAB_LOCUS1319</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001116">
        <property type="protein sequence ID" value="CAG5075165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2EJR3"/>
    <dbReference type="OrthoDB" id="5984008at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015276">
        <property type="term" value="F:ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038023">
        <property type="term" value="F:signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13717">
        <property type="entry name" value="PBP2_iGluR_putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.190.10:FF:000160">
        <property type="entry name" value="GLutamate Receptor family (AMPA)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000080">
        <property type="entry name" value="Glutamate receptor ionotropic, kainate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.190.10:FF:000142">
        <property type="entry name" value="Ionotropic receptor 25a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019594">
        <property type="entry name" value="Glu/Gly-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001508">
        <property type="entry name" value="Iono_Glu_rcpt_met"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015683">
        <property type="entry name" value="Ionotropic_Glu_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001320">
        <property type="entry name" value="Iontro_rcpt_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18966">
        <property type="entry name" value="IONOTROPIC GLUTAMATE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00060">
        <property type="entry name" value="Lig_chan"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10613">
        <property type="entry name" value="Lig_chan-Glu_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00177">
        <property type="entry name" value="NMDARECEPTOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00918">
        <property type="entry name" value="Lig_chan-Glu_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00079">
        <property type="entry name" value="PBPe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="Periplasmic binding protein-like I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="15" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0407">Ion channel</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="8 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 20" id="KW-0675">Receptor</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="17" id="KW-0732">Signal</keyword>
    <keyword evidence="5 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035283862" evidence="17">
        <location>
            <begin position="24"/>
            <end position="937"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="562"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="637"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="860"/>
            <end position="885"/>
        </location>
    </feature>
    <feature type="domain" description="Ionotropic glutamate receptor C-terminal" evidence="18">
        <location>
            <begin position="439"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="domain" description="Ionotropic glutamate receptor L-glutamate and glycine-binding" evidence="19">
        <location>
            <begin position="449"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="518"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="523"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="775"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="site" description="Crucial to convey clamshell closure to channel opening" evidence="14">
        <location>
            <position position="667"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with the cone snail toxin Con-ikot-ikot" evidence="14">
        <location>
            <position position="821"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="787"/>
            <end position="845"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR601508-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR601508-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR601508-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="SMART" id="SM00079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="SMART" id="SM00918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="CAG5075165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="937" mass="107348" checksum="28A1B1CF4C008327" modified="2022-05-25" version="1">MDNWYWWNFILTFIVADCSVVFAQQNQQPTNPRPLNLFVINDEENDIGNNSVKNALVTIKDKDPTVLGNVIVVQINGSDPKAALDKICAAWDPAVRDGGPGVPDLVLDVTRGGYGAETVCSFTAAVGVPTFSAQFGQKNDLRPWLDLSHDQQRYLVQIMPPADLIPEAIRQVCSDMNITNAAIIFDNGFVMDHKYKSLLLNIPTRHLIVRSKTTDKEVNDQLQRLRDLDIVNFFLLGNENTLIKYLDIADMKNFTGRKFGWYALTMSEQPQLKCNNKNITVLLFEPKLTSSNQQHLSSLTNQGIIQKPYLASAFYYDLVRVGVSAMKSAIKNNAWPNAPSHITCDQYNRNNTPSRDGFNLLKWLIDATKTGFEPTFAGFAWDKRNGEHHASFDMYINMKVIDNGNVISTTPMGSWSANVDSPLNITAYETVSSHTAITSFRIVTVQIAPFIYINETTHQWQGYCIDLLTEIQGLMNFEYELYESPDGNFGAMNEQGEWNGMIKELIDKRADIALGTLSVMAERENVVDFTVPYYDLVGISILIRKKKEETSLFNFLTVLNRTVWLCILGAYFFTSFLMWIFDRWSPYSYQNNKEKYKDDEEKRVFHLKECLWFCMTSLTPQGGGEAPKNLSGRLVAATWWLFGFIIIASYTANLAAYLTVARLEQPIESLDDLSKQYKVQYSPIKPSEAYTYFERMTAIEDKFYEIWKDMSLNDSLSEIERAKLAVWDYPVSDKYTKMFQQMKEAGFPQTKEEAINRVRKKLEAHNNTEFAFIGDATEIRYLEMTTCDLISIGDEFSRKPYAIAVQQGSPLKDQLNNAILKLLNQRKLESFKSKWWSRNPNRRNCEKESSQSDGISIQNIGGVFIVIFAGILLACCTLAFEYWYYRYRPRVNAKKQRKANVQERTKISSQRVKPTRFNLKPARKAFEDHGTEFRARF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2EJV4</accession>
    <name>A0A8J2EJV4_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">MULE transposase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS1511</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001116">
        <property type="protein sequence ID" value="CAG5075357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2EJV4"/>
    <dbReference type="OrthoDB" id="7549443at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018289">
        <property type="entry name" value="MULE_transposase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10551">
        <property type="entry name" value="MULE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MULE transposase" evidence="1">
        <location>
            <begin position="3"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5075357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="185" mass="21891" checksum="39E3B3CAC234A5BC" modified="2022-05-25" version="1" fragment="single">AIPIFWTIMTHKGEECYRRVFEFLKQKIPTFNPSSYMSDFEFGLHNAIKDVFPNIDANHCHFHYAQALINKSTEIGLINKTTIRPGTHPEIYIVVKQLIALALLPPNLIKITFENIKRVTMETFGNHFDGLFGYYERYWLKTVKPEGFSIYNLRDDRTNNHIESYHRTLNMHLRKNPHPNQFFCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2EKU1</accession>
    <name>A0A8J2EKU1_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Similar to Vps13: Vacuolar protein sorting-associated protein 13 (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HICCMSTLAB_LOCUS1974</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the VPS13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001116">
        <property type="protein sequence ID" value="CAG5075993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="428159at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006869">
        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045053">
        <property type="term" value="P:protein retention in Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026847">
        <property type="entry name" value="VPS13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056748">
        <property type="entry name" value="VPS13-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026854">
        <property type="entry name" value="VPS13_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009543">
        <property type="entry name" value="VPS13_VAB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16166:SF93">
        <property type="entry name" value="INTERMEMBRANE LIPID TRANSFER PROTEIN VPS13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16166">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN VPS13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25037">
        <property type="entry name" value="VPS13_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12624">
        <property type="entry name" value="VPS13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25036">
        <property type="entry name" value="VPS13_VAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Chorein N-terminal" evidence="6">
        <location>
            <begin position="12"/>
            <end position="1079"/>
        </location>
    </feature>
    <feature type="domain" description="Vacuolar protein sorting-associated protein 13 VPS13 adaptor binding" evidence="7">
        <location>
            <begin position="1863"/>
            <end position="2093"/>
        </location>
    </feature>
    <feature type="domain" description="Intermembrane lipid transfer protein VPS13-like C-terminal" evidence="8">
        <location>
            <begin position="2697"/>
            <end position="2816"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1246"/>
            <end position="1270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1731"/>
            <end position="1752"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="58"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1252"/>
            <end position="1270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF12624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF25036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF25037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAG5075993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="2837" mass="321428" checksum="9CBC2F9E1CE9F2B6" modified="2022-05-25" version="1">MINDNNNNNNKVSKLILKIPFKDIWNGQIDCIIEELYLLIVPSSQVKYDPEKEAKYSLDAKHAELARIEKNKQLLEQSKQAEKIDDSMLEKLLARMIKNIHVEIKSIHVRYEDHVTFKPHEFAIGLTLNRLALESCNTSWMTTENMKDMYLIPQIFKLLTLDGFSIYLNPSLMQFSKQASSTYLKLFHDSIATTENIPPDYQYLLGPINVKAKLKLNPKPETDGSNYQIPKVWLDLEMEKLRIGLTKRQYATLLQLGEGLDRAKKAAPFRKFRPDVPSYRGHYKEWWQFAYKCVLEEHVVRCRRNWNWAHMKEHRDLCREYAEVYQTKLTSKKPVPAIEERLTHCERHLDLFNLVVIRQQIELEVERLAEKQKSIKAERGWFGFLWGSSQQKEEEELNSAAAIMKKFQDAMTPAEKEKLYRAIDYQENSAPAHYPEHYEMVDMMFYLHGLQIIVSDTDKEEPSVLDVALNGVRSAFKLRPAANSVFVTVSLKEMRMLGVKQADEVPKLVLSEHEHSDVLFSVSYEKNPLDKSCGDRVIVNSKAVHFVYDAQTIIELVKLFKIQQAAAERLEGLKEMSALGLEYAIQKHSQLDIQVDLEASQLIVPQNGFYREKESMIVINLGSLKIHTLAKPKDEMSSQTVRQLVSMGKSEEDIMSHLREHSYDRFALKIVNFQALVVTKNEDWRVGLSMSSSPMVILQPTTLEIQFHKCLVTDDPVLPKMRIIGELPSLALCIPGTRLLEAVSIVQSIPFPEDESELQPMPLAKSMSQLSINYVKELAKPVVELTEDVVVQTTDLEAKFVMQEFTLTIFKTEEVQPFIKVEDIKLRLGGIQVTQYHKDEKIFMINTPMTSGHQVYLIVLNFMAVNKRSPEFTTRHGSVVNLLRLEFTTLDVLLHQESLISVLKYINEVQDKVTPCSSLESRVATTRDKFSQLSTIQEDTSMFFKDQQKKAKSRSKKVVVECIDLKIKAKFGTISLKIANDKQEISAFLIQGITAGYIMKVSYSQANVNLTSIIIQDLNPKSIYNNIVSVESGESLQVQAVIYNVEAHENKNNMSIKINMGCHRVVFLNDFVSRVMNFLNNFQAAQEAIAEASAAAAEVAKTNIKDAQASATRVELSIKLKAPVIYVPMNSKSEHCLMLDMGELTIYNSLKTLNVEEEEAPVVDEMKIELANLKLSRVRLTENFQMENEILLLQPVSFGLLIKRNLSSWYTSIPDIDMYGRLKQIEVLLSKQDYAMILKVLEENLNESDESPGQKETARERKDIQRTNAREVDVHITERQTSEGQKSARASVKFEFIMDSFVINLFTGGSKLLQSKTSPLHLPENGLAQFGLTHFAVKGTIFADGLLATSILLMNCTLDDKRQNRQGQLTRIMERTNPLTDAEENSKRSMLDVTIRQSVNDIFVDVKVFSFSIIVSLDYLLKIKDFFTIQAVQTQPQVTVQKYTEVKKKAAASNQSMITLNLHIEKPDIILMEDMDNIDCNCIVMNTELVIKVRLIGDHQVINGSVTDLSVLTGIYNPTKRADSAYQVLKPFSVSIAGSTPDNKGLHIDICCTDIHVSVSPGVIEILSRVMRGLTSSDEQADQFIRPDPSHQGLWLITPYDESEYWFLKTEVATEAFEELNFVEDSVVAYKPELAIVSAPNILLTLEAGVGNKTLPMLMLNLGFQSSVNDWSTRTMSIEATISVIMAYYNSRLALWEPLIEPVEVLRQNGERNSSSWELRSKIQFHDLAPDSRGASAVSPSCESEPEDLHQSKMSIDVDSSENLEITVTKTCFEVMEQLSKAFTSAMDAKESVPRLAPYVLKNETGLKLTLDLQASNFVILDKNLQPEGKEDDKYKEVVLETAATIQLAPLVDKRDSVMLEQMRTSVQMNNDYNLMINFDGIDNQLVIPVLRADKRFFSLKYRKESSEEWGIISDVVVENGSTVVALRSVLQVHNHFTETVSVYYMTKRGNEVECVGNVKPEEKLSLPLDAVYTPTNIYWLFFSVEGYMVSVEPFVWKDLQKTLSMTKLLKCEPRNKQSKEPFYMQVVGEIEQVYFENTTRHTMSSTIYNIHLYPSVYLKNFLPIDIVIILPGMVEEKVVKASTTIQLPTVDSNNSNIIIKVFKRTSIDSGEKREWSSYKSSTTVFAYAVSLALESFRYVNAFSRDKVLTDKCTSLINGGKTKPTPVEEEIFYVSFLDGFQRVLLFTNNLKIAEDCQLVGDLEVIDQEVTLNIHGVGLSLVNNLTRAELLYLRIASSGIIWETRKTIGSRWKPLTSTEVLVIEEGYQKYLREVQLGTEPPYRVMLEPKLMVDFQNMEMLRPHRRYMRRTFQTGLWIQYRSSAHQVQLHAKINRLQIDNQLAECVFPVILAPVPPPKSVANSVIKPFAELSLVKRLLEHSTVQQFRYFKFLIQEFHVKVNDAEETRLFAVDMKLVDEPLMYHVAMITTAEQKNFFDLLHFSPLKIHVSFSMTGGGGGPSAVPQFLNVLLQGIGVTLTDINDIVFKFGYFERDYVFMTNNQLINEATSHYTGQGIKQLYVLVLGLDVIGNPYGLVVGAMKGVEDLFYEPFQGAIQGPGEFAEGLLLGVRSMLGHTVGGMAGAVSKITGAMGKGLAALTFDKDYQRKRQEGLNKQPANLQEGLARSGKGLVMGFVDGVTGVVMKPISGAKEEGVEGFFKGFGKGVVGLVTRPTAGAIDFASGSFGAVRRATELSEEVKRVRPPRFLRPDCLVRPFIHAEAEGNKILFDLEKGKYANTDVYFHHTFVGKDVLLMTDKRIAYIEHSDLFGGWKVQWGYTWQEITEPRIIEKGVQISVKEARKKKLGGLFGSDAAGKIILISDLAVKHQVFNIIRDKIEKIES</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2EN28</accession>
    <name>A0A8J2EN28_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HICCMSTLAB_LOCUS1268</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001116">
        <property type="protein sequence ID" value="CAG5075105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2EN28"/>
    <dbReference type="OrthoDB" id="10313116at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052192">
        <property type="entry name" value="Insect_Ionotropic_Sensory_Rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42643">
        <property type="entry name" value="IONOTROPIC RECEPTOR 20A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42643:SF24">
        <property type="entry name" value="IONOTROPIC RECEPTOR 60A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="336"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="363"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="386"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="574"/>
            <end position="599"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAG5075105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="639" mass="74568" checksum="97D72EB994CE6E40" modified="2022-05-25" version="1">MRLIQIILCYCCVFTGHFSNGSSIHSSEIKSRLINHTVIVIFSDLVDNQVAKRSIDNGSPLIVINGDQRRKQIEGYLPSYSTYILRFESMYKLVSLILGFMRSSIWNIKSPIFILDISKAMHDNRNAGRVLDFLGSLDNLKSYYVCYDDKRDSTIVYTLNPYTQYAPPPWNRVKSANANNNPKTKATMYSLQYPKDLKNNYENICFDKTQYLDDHQIKLLARAISLNSSKQNEQENINEVLKYFDKFKDYGLTSLPDYMKVKASIHVLKKYFGSDFIKYGFDGDLYNRQYDANSFRTQLADTNPDFTDFVTEYHETHYSILTKKTDYLTVVTEISINFQFIFITLFVLILIAVIIVMNNKLNVIEGIMNIVSMSLSMGIISPMGRLSMRIIYFFGFLFIFIVMPEFQGQISSILSQPARRNVETLKDLFDNKYHVFFDGLLEKDMINEKLWATKEDQKYLHPSSGAELAKCALKAQQNSTIACIDNTATQLLFALKLKNLHLSKEIVFKKYYVFWTRKNWALKDKIDRVRSIPVETGLIYHHTEEIEKNRWEKIEKIQKIKEAENYELIDFDNLVFYFIVIAATVLWSLVIFGIELIVYHSHSKYVRQEKARLLFIKRLRAQPRIIFFPGRIVLSNSRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H2R2</accession>
    <name>A0A8J2H2R2_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Cc_HzNVorf64_a</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">Cc_HzNVorf64_b</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Cc_HzNVorf64_c</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">Cc_HzNVorf64_d</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS1598</name>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS1599</name>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS1600</name>
        <name evidence="4" type="ORF">HICCMSTLAB_LOCUS1601</name>
    </gene>
    <organism evidence="2 5">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001116">
        <property type="protein sequence ID" value="CAG5075444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CAJNRD030001116">
        <property type="protein sequence ID" value="CAG5075445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CAJNRD030001116">
        <property type="protein sequence ID" value="CAG5075446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CAJNRD030001116">
        <property type="protein sequence ID" value="CAG5075447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H2R2"/>
    <dbReference type="OrthoDB" id="7656123at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5075444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5075445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5075446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG5075447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="390" mass="45596" checksum="C850E8D70AE5BB90" modified="2022-05-25" version="1">MDIKKFELIIADNIPQGVFIKDQNDQVIENIGISENGQFIYNNIQYVVFENILSLRQHHSTFEYDDLAIKEFSIMNVISAQKVLTWIATIHQHSLDYQTVPCMSSITDALQTISEELKLQADDAAADNNLKEMFNIFLNLLNDLIKEITPEQLAIIYQYSNIAKLKIGDLPLSDLLKISSQYLYDLLSYNESMLERVSLTYPMQMLSYVMRIFLLLFSRFNIPFTDDETILIHEITAILIDLLSDRLTTNVYLKHGNSYATGMIQQINRKYPALANVTDINKVDQFLQNNSDFKNFIEINYRDFNLWPFVLSINMTIQHRVLFNIKSCLDNFRLRDHKKIDVQPKEVIDLLEKICEPYVQTKQYERYNEVCFKQIVSSELFSKICNFMCT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H3B4</accession>
    <name>A0A8J2H3B4_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Similar to ARX: Homeobox protein ARX (Homo sapiens)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HICCMSTLAB_LOCUS846</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001114">
        <property type="protein sequence ID" value="CAG5074074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H3B4"/>
    <dbReference type="OrthoDB" id="6159439at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000679">
        <property type="entry name" value="Homeobox protein aristaless"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050649">
        <property type="entry name" value="Paired_Homeobox_TFs"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24329:SF543">
        <property type="entry name" value="FI01017P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24329">
        <property type="entry name" value="HOMEOBOX PROTEIN ARISTALESS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 5 6" id="KW-0371">Homeobox</keyword>
    <keyword evidence="4 5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="7">
        <location>
            <begin position="43"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG5074074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="92" mass="10891" checksum="16D510A4AAEE7ED8" modified="2022-05-25" version="1">MKIFSIKNCIVISSLKCYSAAYDFSPSPGSEERHQITIGVGKRKQRRYRTTFTNFQLEELERAFQKTHYPDVFFREELALRIQLTEARVQIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H4Y0</accession>
    <name>A0A8J2H4Y0_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Chloride channel CLIC-like protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HICCMSTLAB_LOCUS329</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the chloride channel MCLC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001114">
        <property type="protein sequence ID" value="CAG5073386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H4Y0"/>
    <dbReference type="OrthoDB" id="5837849at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005254">
        <property type="term" value="F:chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009231">
        <property type="entry name" value="Chloride_chnl_CLIC-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34093">
        <property type="entry name" value="CHLORIDE CHANNEL CLIC-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34093:SF1">
        <property type="entry name" value="CHLORIDE CHANNEL CLIC-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05934">
        <property type="entry name" value="MCLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035286756" description="Chloride channel CLIC-like protein 1" evidence="9">
        <location>
            <begin position="23"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="162"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="193"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="311"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="428"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="438"/>
            <end position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAG5073386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="486" mass="54641" checksum="30225E49634EE531" modified="2022-05-25" version="1">MITCNYISKILVILLISGAINCFVDPTLEHTTNRDHYIDPHSIYYNKYTQQLDVKKELQVINRAANKCECHVNSLVKKNDVPDELFSRKLVNLLLAASSFEENGNLLTSSITIVLTPKELRKLKDFSLGKLTIREIDPIISNIFKEPEISYAKNIFTSIKDLLFNVIIYKEVTLVTVVILYISWIILTTEWNLLKLILILILSIFGASFVITWLQLLREAEITLTVKQVQYQKLPIQCNPSKMTWWDKLWTAFSSGEDCRKYYEGMMENPFLQVTPAQALSHMIATCIMTPASMIGNALSDFVNNSTKHLWWPVQLIVAPLLIIGIIIIFIMILIFLAGGTLSWGFGPFSIFSIRGATDSRRDGNLPSTDRQPIQPIYNFNLHGGHIHEIAIKNTDENSTSVDVKSTPAPGTSMSCIQGPVKINVINSSNSSLENSEESGKTLDKVEEISEKEIKDNNDSNGDDNNKNDECICKKKSNPVSESGDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H5H6</accession>
    <name>A0A8J2H5H6_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similar to RAD18: E3 ubiquitin-protein ligase RAD18 (Homo sapiens)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001114">
        <property type="protein sequence ID" value="CAG5074028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H5H6"/>
    <dbReference type="OrthoDB" id="6499288at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097505">
        <property type="term" value="C:Rad6-Rad18 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006301">
        <property type="term" value="P:DNA damage tolerance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006513">
        <property type="term" value="P:protein monoubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039577">
        <property type="entry name" value="Rad18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003034">
        <property type="entry name" value="SAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14134">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RAD18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14134:SF2">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RAD18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02037">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00513">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50800">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAP" evidence="1">
        <location>
            <begin position="258"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5074028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="335" mass="37975" checksum="1BB89FAEA124DBA2" modified="2022-05-25" version="1">MEQYTEITWPAEFSELKLNPNRILEEILINFAKVRNKLHCLVKLNNNSIESGINQSETYLSQNSNQGTSNCVTIEATDPVNKGVDEKNEKNDGQSNNCETFIDSNKLVKNNNLENNANSLEVKNEDKFKSCPVCQLNPNRILEEILINFAKVRNKLHCLVKLNNNSIESGINQSETYLSQNSNQGTSNCVTIEATDPVNKGVDEKNEKNDGQSNNCETFIDSNKLVKNNNLENNANSLEVKNEDNSAKKRPQLPKLVLNLMKDSELKKKLKEVGLPIKGVRKVLEARYQRYCTIYNAECDKKNPRSAAELLKQCNNLEKLEKSIEPLPLNMRSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H5K4</accession>
    <name>A0A8J2H5K4_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">EB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HICCMSTLAB_LOCUS1012</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001114">
        <property type="protein sequence ID" value="CAG5074308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H5K4"/>
    <dbReference type="OrthoDB" id="504708at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006149">
        <property type="entry name" value="EB_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39069">
        <property type="entry name" value="ECDYSONE-INDUCIBLE GENE E1, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39069:SF8">
        <property type="entry name" value="FI17111P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01683">
        <property type="entry name" value="EB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035208452" description="EB domain-containing protein" evidence="2">
        <location>
            <begin position="19"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="347"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="domain" description="EB" evidence="3">
        <location>
            <begin position="161"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="EB" evidence="3">
        <location>
            <begin position="295"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG5074308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="375" mass="41102" checksum="8E100692F7D19A66" modified="2022-05-25" version="1">MADYAIFWLVMFFGTAASSNLTADFNEYTTEDSLPSIPNVSDIFKKCQTNNDCTIKNSECTNEQCRCKQYYFELNNQCVPGLGADCSKTIKCQALNSTCGSTTHCVCQPRFIFSNTTHCLPIQSFGQPCEESEQCSCMHDEKCQLSDTFKDIICWNKQCKCQPNHHYAFRRNACVHSSGIGEQCSIDENCEKLLFAECYENKCVCKPNYFASEGKCKIGLNANCVTTGQCSAVEHAKCEKGKCKCAEPFVERSVELCVLVSSFGGECEYVEQCTSQTSNATCEAPTDGAKKVCGCGTGQHHHASGCFPTRTLDERCDSDSECFVTSKYDSVACTGNKCVCVEGFEKVNGTFCGSAGSILGSVVLVFFMVVVKTAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H5R0</accession>
    <name>A0A8J2H5R0_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Similar to ND-23: NADH dehydrogenase (Ubiquinone) 23 kDa subunit (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HICCMSTLAB_LOCUS1646</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="2">Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the complex I 23 kDa subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001116">
        <property type="protein sequence ID" value="CAG5075492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H5R0"/>
    <dbReference type="OrthoDB" id="204405at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003954">
        <property type="term" value="F:NADH dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006120">
        <property type="term" value="P:mitochondrial electron transport, NADH to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032981">
        <property type="term" value="P:mitochondrial respiratory chain complex I assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.3270:FF:000001">
        <property type="entry name" value="NADH-quinone oxidoreductase subunit I 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01351">
        <property type="entry name" value="NDH1_NuoI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010226">
        <property type="entry name" value="NADH_quinone_OxRdtase_chainI"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01971">
        <property type="entry name" value="NuoI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004538">
        <property type="entry name" value="PRK05888.1-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004539">
        <property type="entry name" value="PRK05888.1-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10849:SF20">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] IRON-SULFUR PROTEIN 8, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10849">
        <property type="entry name" value="NADH DEHYDROGENASE UBIQUINONE IRON-SULFUR PROTEIN 8, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12838">
        <property type="entry name" value="Fer4_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54862">
        <property type="entry name" value="4Fe-4S ferredoxins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-1278">Translocase</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="9">
        <location>
            <begin position="89"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="9">
        <location>
            <begin position="128"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAG5075492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="197" mass="22467" checksum="2EA1CA126088A23B" modified="2022-05-25" version="1">MVDTQITKLSPLRAISVQPSRSKYFIITPKDDPHWPDALPDEGTTVYARELANGMMTSLSCFFKEPVTINYPFEKGPLSPRFRGEHALRRYPSGEERCIACKLCEAICPAQAITIEAEERSDGSRRTTRYDIDMTKCIYCGFCQEACPVDAIVEGPNFEFSTETHEELLYNKEKLLNNGDRWESEIASNIQADHLYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H681</accession>
    <name>A0A8J2H681_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase</fullName>
            <ecNumber evidence="3">4.1.1.97</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HICCMSTLAB_LOCUS2601</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>5-hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate + H(+) = (S)-allantoin + CO2</text>
            <dbReference type="Rhea" id="RHEA:26301"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15678"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:58639"/>
            <dbReference type="EC" id="4.1.1.97"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Purine metabolism; urate degradation; (S)-allantoin from urate: step 3/3.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.97" evidence="3"/>
    <dbReference type="EMBL" id="CAJNRD030001117">
        <property type="protein sequence ID" value="CAG5077958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H681"/>
    <dbReference type="OrthoDB" id="9970124at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051997">
        <property type="term" value="F:2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006144">
        <property type="term" value="P:purine nucleobase metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019628">
        <property type="term" value="P:urate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3330.10">
        <property type="entry name" value="Oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018020">
        <property type="entry name" value="OHCU_decarboxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036778">
        <property type="entry name" value="OHCU_decarboxylase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43466">
        <property type="entry name" value="2-OXO-4-HYDROXY-4-CARBOXY-5-UREIDOIMIDAZOLINE DECARBOXYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43466:SF1">
        <property type="entry name" value="2-OXO-4-HYDROXY-4-CARBOXY-5-UREIDOIMIDAZOLINE DECARBOXYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09349">
        <property type="entry name" value="OHCU_decarbox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158694">
        <property type="entry name" value="UraD-Like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-0659">Purine metabolism</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase" evidence="7">
        <location>
            <begin position="12"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF09349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG5077958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="115" mass="13399" checksum="F756D3D747339790" modified="2022-05-25" version="1">MGETKLTIEEINSMSKIEFCKIFGNIVEHLSEATEAIEELRPFEHVSQLENLFCNFIEYLDDSEKEIILKNHPELTGEIYNEKILTTESQNEQKIAGINQMTTEEKILFNNFNKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H6U5</accession>
    <name>A0A8J2H6U5_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Similar to caup: Homeobox protein caupolican (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HICCMSTLAB_LOCUS3074</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5080674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H6U5"/>
    <dbReference type="OrthoDB" id="5399138at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048468">
        <property type="term" value="P:cell development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030182">
        <property type="term" value="P:neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003893">
        <property type="entry name" value="Iroquois_homeo"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11211">
        <property type="entry name" value="IROQUOIS-CLASS HOMEODOMAIN PROTEIN IRX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11211:SF40">
        <property type="entry name" value="MIRROR, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00548">
        <property type="entry name" value="IRO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0371">Homeobox</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Iroquois-class homeodomain protein" evidence="3">
        <location>
            <begin position="365"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="72"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="243"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="337"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="380"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="495"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="19"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="72"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="244"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="267"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="281"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="354"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="393"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="507"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="538"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="566"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG5080674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="566" mass="58982" checksum="89EEC588FD32FF42" modified="2022-05-25" version="1" fragment="single">MSQFSYRGSPNLQCPVTVSGALASSSPSPASGSLLTGSGVSSTGGSENHPLTSPLSSVARMAVTSAIIRPAAGSPASSVSPSSQHQQQQQPHGPPPSGPPSGRCCDTGRPIFTDPVTGQSICSCQYELLGAGYQRLGGITPAALSMYSTPYAAAAAAVASEGMAAYFPALGAEQTPFYSPTAAGLDLKENLSAGAAGWPYPAVYHPYDAAAFASYPFNGYGMDLNGARRKNATRETTSTLKAWLNEHKKNPYPTKDSKDSGTGSSEDGERPTNRLDLLHPSTGSGLQSRIQESEWSESRADSGPDSPECLYDQREPPRHPLQLQHPAYLAAHNRLLRHPSPESTSPTGPIHLPTSTSTSSGNSTENSTKPRIWSLADMASKDADSPVPPTPPSSGTLTGLGSPYQNSPGGGKIVSPLANRFPPHHHIHPAISGSQYVRPHPDFYRNFYGAASQLGSGDMAFLESYSRSLGGLGLAPNSVPAGILTSTPPAVSTSITVKPFPLNGSTSNSNSNSNNNNNNNNNNNSNNNNNSGGLMTPSEVSPSSSVSSHSEQRSPHPSEPGNKSPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H6X2</accession>
    <name>A0A8J2H6X2_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS2690</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001117">
        <property type="protein sequence ID" value="CAG5078257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H6X2"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035326092" evidence="2">
        <location>
            <begin position="22"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="278"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="310"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5078257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="370" mass="43243" checksum="B919B0A8B9412106" modified="2022-05-25" version="1">MQFLKIILCFCCVFIGHFSDGSNIHTSEIKMRLMNHTMLMMGSIDKGFMKNSNSLIISSDLFMPSKIRNIKSAIFILDHSEGPYDINASEVLRFFGSFDILVAYYVYLNYALVEVSIDKKLNGVYFNKYFSVTVEPYFSPSLYNRKKTFGCPTHSLEKSEELMNFKENYQNIYFDKTHYLDSHEIYLIAFIHLCRKGTFKDMGLNSLPDNMKLSASIHLHNYYFNLTLIKNSIDVKLHTPDTNYKLTDFITQYEEIHFSILTKKTDYLTAFREININLPLIFIAILMLVLIAVIIIINNQFHVSEGIMDIVSMSLSMGIMSPMQRLLMRIIYFFGDRRRSKVFAFKKSFNFKEMCDHSSTKFNCCLYLFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H7W0</accession>
    <name>A0A8J2H7W0_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">polynucleotide adenylyltransferase</fullName>
            <ecNumber evidence="3">2.7.7.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HICCMSTLAB_LOCUS3374</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DNA polymerase type-B-like family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.19" evidence="3"/>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5081770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H7W0"/>
    <dbReference type="OrthoDB" id="273917at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031499">
        <property type="term" value="C:TRAMP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990817">
        <property type="term" value="F:poly(A) RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043634">
        <property type="term" value="P:polyadenylation-dependent ncRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031123">
        <property type="term" value="P:RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05402">
        <property type="entry name" value="NT_PAP_TUTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.460.10:FF:000006">
        <property type="entry name" value="non-canonical poly(A) RNA polymerase PAPD5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1410.10:FF:000003">
        <property type="entry name" value="non-canonical poly(A) RNA polymerase PAPD7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054708">
        <property type="entry name" value="MTPAP-like_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002058">
        <property type="entry name" value="PAP_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045862">
        <property type="entry name" value="Trf4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23092:SF15">
        <property type="entry name" value="INACTIVE NON-CANONICAL POLY(A) RNA POLYMERASE PROTEIN TRF4-2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23092">
        <property type="entry name" value="POLY(A) RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22600">
        <property type="entry name" value="MTPAP-like_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03828">
        <property type="entry name" value="PAP_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81631">
        <property type="entry name" value="PAP/OAS1 substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Poly(A) RNA polymerase mitochondrial-like central palm" evidence="9">
        <location>
            <begin position="168"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="PAP-associated" evidence="8">
        <location>
            <begin position="355"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="98"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="485"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="105"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="485"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="530"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="542"/>
            <end position="556"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF22600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAG5081770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="556" mass="62585" checksum="4E51A94D222D56C5" modified="2022-05-25" version="1">MDPTIGWYQPEQFGPAKDLWLQIWIAEKGLDTLTLKNENSIVGCGGGGGGGGTNTLVNSVGGGVPTAMATSGNKGVQDFIPLQDSHSNAALNNRVAHQEDHRNHQTTNHLQRSLPVTSNMYYNPSRRKNDNRASTYGLNYNHDTLIGEYGGCPWRIPSKQYSPGIIGLHEEISDFYNYMCPTIEEHNLRIRVVKRIESIIYEQWPESKVEVFGSFRTGLYLPTSDIDLVVIGRWANLPLFTLENKFLEYDIAEPSSIKVLDKASVPIIKLTDKETDIKVDISFNMNNGVKSAELIKNYKRRFPVLDKLVLVLKQFLLQRDLNEVFTGGISSYSLILMTISFLQLHPRQNVHENSNLGVLLIEFLELYGRKFNYVKTGIRVKDGGTYISKEEVQRDMIDGHRPSLLCIEDPLTPGNDIGRSSYGALYVKDAFDYAYHNLAQAVNPTNFVDSSKHSILGRIIRVTDEVIEYRKWIKDSFPSSVLELDSLSSSTGSDASTLSAPASDTDSEHSRGNSPNTGGQIEDRNRDRNAYNNQQNQYTHNPWKKPYKTGHGRPRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H8B2</accession>
    <name>A0A8J2H8B2_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS4078</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5084331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H8B2"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5084331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="63" mass="7086" checksum="AE50E3B179388331" modified="2022-05-25" version="1" fragment="single">MGATAIFVYSHVGLSHERVIEQDTNPEHTSIIKENSVNGSHFYQDLSSFGSRQNKIVHQQSEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H8L8</accession>
    <name>A0A8J2H8L8_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Similar to Atxn10: Ataxin-10 (Mus musculus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HICCMSTLAB_LOCUS4334</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5085293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H8L8"/>
    <dbReference type="OrthoDB" id="379794at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031175">
        <property type="term" value="P:neuron projection development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051374">
        <property type="entry name" value="Ataxin-10/CTR86_families"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019156">
        <property type="entry name" value="Ataxin-10_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13255">
        <property type="entry name" value="ATAXIN-10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13255:SF0">
        <property type="entry name" value="ATAXIN-10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09759">
        <property type="entry name" value="Atx10homo_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1" id="KW-0132">Cell division</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ataxin-10" evidence="3">
        <location>
            <begin position="347"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF09759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG5085293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="448" mass="51270" checksum="057C3B47C5A0471A" modified="2022-05-25" version="1">MAVSGYMSHEMADCYIEDVAAYVQFIIVEIPSPIKVTILKCFKLACIRDIEYHHKPYKKNYSSIFSEGFDPNYPTSCFPFDKVTKWTIDNLIAILESPDEINIIKESLSFLCNMLAYNDDNLLDESYREKAINLLGKLLMNCKEDGIVIRACCLTHNIMNTWYRHFDVQNLVEITEGLLKADECGFKAARDSLMILIKKDAFVRSYEDLSLDSRLYFLELVCKLVNNELEKMEDFFLPEDTVLFLIKRFKERSNLILKTEESYVKEQMKEPAEVIILLDILGTLSCELEIVKRDASLLINVVFLLKAIHMAGKSSSNNFTPLQKLAQVAPSNNSDREAIESHVAFGFKSSLVRFIANDVYKNRANQDKVQELDGMSLILDCCNIDARNPLIMQWGILAIRNLLENNPANQELIRNSQKIRFIDTEVIREMGITLNQDGNPIGIVPLPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H8Q4</accession>
    <name>A0A8J2H8Q4_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Similar to ZNF251: Zinc finger protein 251 (Homo sapiens)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">HICCMSTLAB_LOCUS4315</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5085236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H8Q4"/>
    <dbReference type="OrthoDB" id="8117402at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990837">
        <property type="term" value="F:sequence-specific double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000075">
        <property type="entry name" value="Putative zinc finger protein 536"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000100">
        <property type="entry name" value="Zinc finger 45-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000744">
        <property type="entry name" value="zinc finger E-box-binding homeobox 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000184">
        <property type="entry name" value="Zinc finger protein 333"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000303">
        <property type="entry name" value="Zinc finger protein 41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000110">
        <property type="entry name" value="Zinc finger protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1800.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012934">
        <property type="entry name" value="Znf_AD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24394">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24394:SF44">
        <property type="entry name" value="ZINC FINGER PROTEIN 271-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07776">
        <property type="entry name" value="zf-AD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13912">
        <property type="entry name" value="zf-C2H2_6"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00868">
        <property type="entry name" value="zf-AD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51915">
        <property type="entry name" value="ZAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="9"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6 12" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="ZAD" evidence="16">
        <location>
            <begin position="25"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="218"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="399"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="445"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="472"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="520"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="552"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="580"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="608"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="636"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="415"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="495"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="356"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="430"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="506"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="27"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="30"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="71"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CAG5085236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="733" mass="84102" checksum="068678133E9245F1" modified="2022-05-25" version="1">MEISDDLTRNSQRNQDNYLEALTGDECRLCLQKSKESWPLFQSNDNQLPQKIMACAAVQILEGDGLPSTICSPCNRLLELSYNFKLTVEKTDSKLRSLSYPKPIIVFTESLSHPLESIPKIEDRLISQSLESSHLLQLNSSIDNTIIFRVEDLKPDKDSQVVLLEKLDEFDDHMHNKDFFQIKTDILEPSAPENFKDLDKNSLEKKSESINKKSNLMFICHICTEQFNCVEKLKEHVTTHDSLKGSNSNCCSDEQSVDDHLINDNSIDNNSDSEISVNDDHNSLNNHHNLLNDIDSDNLLNNQACIDQNLVQNFKNQNLVQNLDTQNLDQNFKNQNLDQNFKNKNLVQNLDTQNLVQNLDQNLQTQNLEAQNLVENLQSQNLDQNLQTQNLINKKSSKYKCKFCPKQFTYEKSYQTHAKSHKDPNHQPNSDEEDQDPEDDLPEGLQCLQCGKLFATKRNLKRHISTHTGVKFNCETCSKEFSRLDKLKEHEYAKHSADFTDSDEDKPEKESKELKKNRPHKCSLCPKAFAQQQSLNNHLERHKRVKDTQKRFLCDVCSKCFAQSGSLVAHMRTHTGVKPYVCSVCSRAFTKSTYLQLHLRTHSGEKPYICQYCSRAFARANTLARHITMHTGEAKYHCQICRKSFRRLTSLNEHTYTHTGQRPYACKICTKRYNNAGSLYAHTKKCKAQNGAEVGKETLPLEGKAVDPLAIDESFTADNKEFKAGFFNIYPSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H9F5</accession>
    <name>A0A8J2H9F5_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Similar to ZFAND6: AN1-type zinc finger protein 6 (Pongo abelii)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HICCMSTLAB_LOCUS4926</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5088652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H9F5"/>
    <dbReference type="OrthoDB" id="428577at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1110.10:FF:000001">
        <property type="entry name" value="Zinc finger AN1-type containing 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.4770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1110.10">
        <property type="entry name" value="AN1-like Zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035896">
        <property type="entry name" value="AN1-like_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050652">
        <property type="entry name" value="AN1_A20_ZnFinger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002653">
        <property type="entry name" value="Znf_A20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000058">
        <property type="entry name" value="Znf_AN1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10634:SF149">
        <property type="entry name" value="AN1-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10634">
        <property type="entry name" value="AN1-TYPE ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01754">
        <property type="entry name" value="zf-A20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01428">
        <property type="entry name" value="zf-AN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00259">
        <property type="entry name" value="ZnF_A20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00154">
        <property type="entry name" value="ZnF_AN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118310">
        <property type="entry name" value="AN1-like Zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51036">
        <property type="entry name" value="ZF_A20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51039">
        <property type="entry name" value="ZF_AN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="A20-type" evidence="6">
        <location>
            <begin position="2"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="domain" description="AN1-type" evidence="7">
        <location>
            <begin position="95"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="51"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG5088652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="160" mass="17149" checksum="472EDA6D1C71B2F4" modified="2022-05-25" version="1">MEPVEEFCLSGCGFFGSPATEGHCSVCYKNVILKQQLASALAAALPKSAAAPGATCSNAESTKGPLGSAGEKITDDVTPMEAVDREVGTSDGEKPKKRNRCFTCRKKLGLTGFDCRCGGVFCSLHRYSDMHKCNFDYKKMAAEEITKKNPVIIGSKVQKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H9I7</accession>
    <name>A0A8J2H9I7_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similar to Transposon TX1 uncharacterized 149 kDa protein (Xenopus laevis)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS4056</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5084250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H9I7"/>
    <dbReference type="OrthoDB" id="7615957at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071897">
        <property type="term" value="P:DNA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47027">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47027:SF20">
        <property type="entry name" value="REVERSE TRANSCRIPTASE-LIKE PROTEIN WITH RNA-DIRECTED DNA POLYMERASE DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5084250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="512" mass="58842" checksum="0DB64E93DAE59358" modified="2022-05-25" version="1">MSVRFQGIPAYALFVDFQRAFDSVPHDKLWNKLIHLGLSTKITNILKKLYASAEMQVRHENLLSEPIRITLGVLQGEILSALLFILYISDLVPHLQSKNIEGLNLGGSDHLLALKYADDLVLLSRTAVHLKNQLKALESYCDSNELTVNISKTKILRTSSSGRAGKRNETFFYKGSTIDLVSSYTYLGVTFNTSLQGDAATCMAINKNRIASGTVSSILTKLKAESWLGKVQTYNCMCRSMLLYLAHLWCLKPNNLERLESAHLEFYKKILSLPVCTPNYALRIELNLQHTSILVLKQALTWVIRILEMDESRLPKKCFLRLNALRYTFNNSKHNWVQQLAVLLNLVQEADLLNKLDPTIWKSRKQDILKKYSNHLKKLDADRYANSSSCQFILPNPIYNLSQVLNNPQRLIKPIIQIRLSNFYSSFISIDRETLTLTPQKHCQLCHLQENEDIIHFLTRCPFYQNVRTLFWGENTPQEIMEAVLGIHRQPNLKKILNYLKSCFNTKNNYSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H9K6</accession>
    <name>A0A8J2H9K6_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Similar to nep-21: Neprilysin-21 (Caenorhabditis elegans)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HICCMSTLAB_LOCUS4666</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase M13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5087976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H9K6"/>
    <dbReference type="OrthoDB" id="6475849at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08662">
        <property type="entry name" value="M13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1380.10">
        <property type="entry name" value="Neutral endopeptidase , domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000718">
        <property type="entry name" value="Peptidase_M13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018497">
        <property type="entry name" value="Peptidase_M13_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042089">
        <property type="entry name" value="Peptidase_M13_dom_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008753">
        <property type="entry name" value="Peptidase_M13_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733:SF237">
        <property type="entry name" value="NEPRILYSIN-LIKE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733">
        <property type="entry name" value="ZINC METALLOPROTEASE FAMILY M13 NEPRILYSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01431">
        <property type="entry name" value="Peptidase_M13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05649">
        <property type="entry name" value="Peptidase_M13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00786">
        <property type="entry name" value="NEPRILYSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51885">
        <property type="entry name" value="NEPRILYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M13 N-terminal" evidence="10">
        <location>
            <begin position="48"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M13 C-terminal" evidence="9">
        <location>
            <begin position="478"/>
            <end position="679"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF05649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAG5087976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="702" mass="81502" checksum="84B57FA729EF15CE" modified="2022-05-25" version="1">MGWLFDIEAENNGENKNELRETETVCLTKECQIIADEFLRSMNKSIDPCDDFYKFTCQGWTTADAPSYLPLWARFTMFQEVVYKRLKGILEKDQQPDDILPVKQAKKWFKTCMDSEGLNRRGIKTLESILMRVGGWPITLDSEEWDEDVYNWEKIDNYYFQLTSSHIFYQFNIFPYVGAMDDDIGISSGDLPLGEKLSDKYRDYKGNDYDAYNEFVYKIREDDDEGDGFQRQRIGKFIDFYESEIKKSNLEAFKIDFKKSITELLAIVGQKYNSSMEMSIKDDVYFPKLAKLMKKTPKKVIINYMHWHFVSNMLEHTTDEMRNLIFELMEKEIGVTERPPRWMECVELTKMQEAVAYAFMKEYFPPETNTKMQEVINNVQGSVETLIDNSNFMSTEVKKAWITKLRNMKFLVGFPQSFQNNSAIIASFHGLIIGSDLIDNNLSYNRYKVRFKLRNFMSTGPIVGWSTEPLTVGASYGGNVIVVPAALFQPPLLTPNLPEFVNYGILGTTIGHEIGHGYDGMGIFDSGDYEEIPILKEDENIVLDSFKCFSEFYENFMNKTDYSEDELSFGNRTLGENLSDAMGIHAVFDAYKELLSKTGGADRKLPNFEEFTDEQMLFISYGNMWCEIATEQFAEKQRRNDVHSPGRIRVLGALKNSPEFAKAFNCPKRSSMNPDKKCNMWEAQMKPKSRRRYEKHHTWVVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2025-04-02" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HA28</accession>
    <name>A0A8J2HA28_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS3752</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5083167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6381815at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017956">
        <property type="entry name" value="AT_hook_DNA-bd_motif"/>
    </dbReference>
    <dbReference type="SMART" id="SM00384">
        <property type="entry name" value="AT_hook"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="37"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="149"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="244"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="400"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="490"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="558"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="766"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="842"/>
            <end position="876"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1379"/>
            <end position="1459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1803"/>
            <end position="1992"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2005"/>
            <end position="2226"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="345"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="107"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="191"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="202"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="254"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="293"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="418"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="465"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="492"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="587"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="644"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="842"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="859"/>
            <end position="871"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1818"/>
            <end position="1831"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1832"/>
            <end position="1841"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1868"/>
            <end position="1880"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1904"/>
            <end position="1916"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1918"/>
            <end position="1928"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1943"/>
            <end position="1956"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1982"/>
            <end position="1991"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="2027"/>
            <end position="2070"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="2139"/>
            <end position="2172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="2214"/>
            <end position="2226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5083167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="2226" mass="242503" checksum="2D652228B114CEDE" modified="2022-05-25" version="1">MWSEALLFTGQDKYRSKTKEGSGWMSKFPDDVATAERLTNGDPEILNTPKFSPEEKPDISYLFGGEKKPPKKKKDKEDRKSFGPSNPQRKITHPRFRGSSDHEVRIRTNQYSGSSLPSTPENTNVRNYDCPVCSFTSTRVNVLISHVRSHKSSGYESPLRPRASLPPKASRTHSGNSLESPKRKYVRKTKSMSAKASSNDKSPGETNKRKYSKNIDNKIVKKKKTDPELREKLLADWDIGSSDEEINTESFNSPKEELEKLNENNKEELETEKLKENNKEELEPEKLKDNLTEAENAPKNNENNLIKLNDKDEKSKFSCFDFDEDEPEPPVTIPVRKLGRVFGEKTSLKKEIIKEFNKSQELENKRDEMNKLNDDNKLLEEMNKEADDIDNLVAKISKTTSLNSPKKKLEEEEELSFKSGTSDTLILSRSESDLKSEASGLSEGPELLGAVASESDNLSSKNDQDQEIPMEVDNKEEELEILEIIETEEIEAEKSAEDEKVPLKNSPELEKKSKIMRYSDLERVTIEEEETLPVRSTIGQKSGNLSMGWSQLNEIIGSSLEKNSETPAPVKRGRGRPPKAKNLNSLVKEEVKEVGPKIKEYERKTSQSESDTERSYSGRRRKPNKKYLEDAYSSPSSSSGFAFRTDDSQSEEEKKEVEKPVVVKRKRGRPLGWKKNKNNKVSEVREPSVEFELSETLDSVSEEITEAVEVKERVIDPVDSLEGFEEVKVDKEDKEGRVHLTNLTSAVEIRSVLKEDLVEIDIEDQIGPVAPEATPVDDYNESQTQDQVDRAKLMNDLEDQDDDASGFSEKVEILPPKKSQIKKFELSQIDESQIDLENEIKKHVDEEAGLGEKPKIEGEGMEDEGEEEDEELKPTTLIEEPVTNLETIEALEEPTKPDAQFSEPVLEEPEKIVKLVSSPGPMIDELESTIPVKKREKPRIIENVQLKEPMHILKSKLLEKPKGKHKLDDHRLGSKAKIIKLDPSIKRKGGMSYGQKIQVLKAADANDKLQIGQPETVETISIAEGQKLIQSSNLEGMELDINSMPFVLSEDLTPDSIEQMPMVISSIMPTSSGLRAAAQSLPRAAPALAPITSDIETITVDASPKKKASPAILKTKPKAKPTITSIKTLSSPVGGIKSLKFQNTKTSPMVSQKNTPSKYVIVQAGAGGQQMRYMIQGKPTTKVAKVAAPLGNKPSTNPQIVSQGGKVVILTSPQSGQAKVVPFKNSLIKGQVKMPKIDSPTTSKSPKIVTSLLGSKSIVGSPKTILSPKPGQVYTPSNLLPGTSKTILPMPGKITGVVPGKGTVLTPITGQQVKAIAAKSPGKPGPKVTYQLQKGLPMVAKMQKIPISPAGSPVRNSKPTGIVMTQKTPLPTKKLIRPAGPPGTGMPMGSPVQGVDKIVKSPRGRGRTKPEIKPQVKSLPKIKSKEFTGQLAPGSPGQPGQPGPSNSLPVPGLVPTATAGPSVAATENLEVLEQKEEKAAPQIMALPTESSDGTQTYVLVTIDDQGQIQPLDNNTLMSLEGTIQNPDGTRTLYIDPASLGEGNLDNIVLQFDNSAPPGPPAGASSSSDFVRQVPTTNQDILAAALANTDFQQEILPETTVGSLTAGLTATSLINQTILQSTIIPTSEPISSPSVLETSLTLNQPIMTPLEVPTSLPIQVDAVAAHSAPNLEMPITMTNPAITYIQSELPGNSMPDIGEVEAPVASAENYLVLPSSEGQNYAVSMAENITIDSTAPTPSMPIIDDGFSDDVKGQQGQVFEEAAQEQSGEVRDMPIVADETSMEVDHVESEVQAPVEETLEKIQEVQQEQVPEACGLGKSEPSQSYEPSSEIPTQSKSQSTEASPVAYEEAMVEESEPPTQSYDDVKAEATQSYNVPTQSFSEDPARIDDPDFPTQSYEVEKPDNVDGDGIIETDGELSQEGNIPSQSNDIDGIGTSFMGDDRNSCNIAGTASGTGANFNEDETASSSYVPETPETQERDQDQESAISTSSYEIPTCEEINIASSSVIPDTSVDAEHTSIHNNGVPEIPTSSYNLNPDSSSGGSIDAVPSSSYEDNQVESVVEQNVSTSYQVPISMPGLEGNAGFDTSEATQSYFVPEGPSPSYQPQTASPSYYEPPPESEATQSYYSQDLEQRTADVEQSASQSYYQESTTSSSSGSTLTSSSATTTAAATTTNDEELRLGQVGEATPTYSTERYPVDYNIDNSSPIDRHDLVESSVSATPQPTESL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HAN8</accession>
    <name>A0A8J2HAN8_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS4225</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5084900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HAN8"/>
    <dbReference type="OrthoDB" id="9995573at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31912">
        <property type="entry name" value="IP13529P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31912:SF34">
        <property type="entry name" value="NOTOCHORD-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5084900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="349" mass="41245" checksum="C296D5DEB4B31042" modified="2022-05-25" version="1">MHDILEGVLEYDLGLILNYFIKEAKLFSLDNFNDRIESLYYGPDEIRNKPRDIKKNQITEKYLKVSAAEALCVIRNLGVLIGHFIPVDDLHWKLCIYLKVIIDIVTSPIIHDDLCDYLQRQISEYLRLLTSLFSNCLKPKHHFLLHYSRVMKLMGPLWNLNTMRAESKNKEAKVDARTAVSRRNICKTIAIKQQLHLSYRFTLNHQNVCKYDYEVDDVTLLKDLPQYSSYCQYLPKSTIEHIYEIKLLKFKARSIKIDIILMIPTSSGPNFFEVFIIIHDFNDQLFIITKNLTDYCYYDEHYQAYEIHPYALNDTPNWRIIRSDDLESCCITHVTKAGNEKKYIVKRWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HBC5</accession>
    <name>A0A8J2HBC5_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Similar to Tret1-2: Facilitated trehalose transporter Tret1-2 homolog (Drosophila simulans)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HICCMSTLAB_LOCUS5845</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5092004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HBC5"/>
    <dbReference type="OrthoDB" id="6612291at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050549">
        <property type="entry name" value="MFS_Trehalose_Transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48021">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48021:SF89">
        <property type="entry name" value="FI02132P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="54"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="99"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="153"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="185"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="210"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="246"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="347"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="382"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="413"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="445"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="481"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="513"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="63"/>
            <end position="536"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG5092004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="574" mass="64145" checksum="A07A5D5CDB5EC23A" modified="2022-05-25" version="1">MINKKKSYFLILTVDFRIFFHIYIYIKMETLELKELKIVAVSDEEIKKQQKRGVIYQMSMSLLANFTILGPAMSLGYSAVILPTLRSANSDLPITEDQASWIAGSAAFGTPIGCMLSSLIMRRGRRLSLMVTSTFSLIGWVLIYMSTNYEKLVVGRIIAGIATGLASVPATVYTAEVADPLWRSVMVTWSSIAIASGILLVYVFGYFLQVIIIIIIIIIIIIIIIIIIIIIIIIINNNIFQDNWRLLALICGLFPAISIIMMLLALPESPLWLRDKGRIDEARILMKKFRGVSKDNATTPAIEQELNNRPRISNNNNNNNNNNNIIISSDKQSIFKYLTKKSSLKPFGIMMGFFFFQQFSGIFVVVFYAVDIIEEAGIQINGYFGAILIGITRLAGSIIVACASKKWGRRIPSIISGVGMTVFMGLLSVYLYLIDRGINIGDTGLIPAICILAYIFMSTIGFLTLPFAMVGEIFPTKVKDILSGLTVCFAYIFSFIIVKCYPDMILAMGKHSVFIFFSVISLLGTVFVFLCLPETKGKTLKEIDQLFSRKKNSLELIPEKEKIVIDKNKHTSDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HCF3</accession>
    <name>A0A8J2HCF3_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS6773</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5093373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HCF3"/>
    <dbReference type="OrthoDB" id="8192078at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5093373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="376" mass="43248" checksum="3B5B9E22C6AD7105" modified="2022-05-25" version="1">MLFCDDYETGNALGSHSGCNKLCGCYITLPCFPPQYQSSLDTIFHALLFYSKDRDQFGNASIFRLLIDQLNDLETQGLELELLQGKVQIYFKLGLIVGDNLGLHSILGFVESFNANYACRFCKMDKDLRSMASLKDPVYIRTKSTYEKDFFHRLNDFHVKENFAADIMHDVFEGVCMFDMAALLKHYVTVEKFFPLEQLNHRMHIHIWGATESNIPLPIADNDFRNEHLRRSAAEMLTFVRHFGLLVGDLVPEDDPAGQIYSILRQIINIILSPSVQRGCHLMLRVLIHEHHTLVRSVLKRQLKPKDHIFTHLPTIMAECGPPIHFWCMRFEGKHRESTVPASVSNCKKKHCSNNCYEASVKVCLPTLHDEYKSCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HCR5</accession>
    <name>A0A8J2HCR5_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Similar to AGBL4: Cytosolic carboxypeptidase 6 (Homo sapiens)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HICCMSTLAB_LOCUS7154</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the peptidase M14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5093828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HCR5"/>
    <dbReference type="OrthoDB" id="10253041at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004181">
        <property type="term" value="F:metallocarboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06908">
        <property type="entry name" value="M14_AGBL4_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.3120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050821">
        <property type="entry name" value="Cytosolic_carboxypeptidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040626">
        <property type="entry name" value="Pepdidase_M14_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000834">
        <property type="entry name" value="Peptidase_M14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12756">
        <property type="entry name" value="CYTOSOLIC CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12756:SF9">
        <property type="entry name" value="CYTOSOLIC CARBOXYPEPTIDASE 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18027">
        <property type="entry name" value="Pepdidase_M14_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00246">
        <property type="entry name" value="Peptidase_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52035">
        <property type="entry name" value="PEPTIDASE_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M14" evidence="5">
        <location>
            <begin position="177"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="452"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="578"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="461"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="593"/>
            <end position="603"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS52035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAG5093828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="603" mass="69097" checksum="64D978B3FEBF2C87" modified="2022-05-25" version="1">MIKYLTQFYQRELKIKKVSFADSDDSDAEGGLGNVSRLIIRPPGHSGKAKKGHLCFDAAFETGNLGRVDLVSEYEYDLFIRPDTCSPRLRLWFNFTVDNVRLDQRVIFNIVNISKTRNLFREGMTPLVKSTSKPRWQRIPRRQVYYYKSPQHQNHHVLTFAFNFDREDDVYQFSLSYPYSYSRYLGHLDNLCTKCSSVKRETLASSIQKRKVELVTIGSNAEEKQRRVVAVLSRVHPGESPSSFVCQGLMDFLVSAHPIAQVLRDYVVFKIVPMLNPDGVFLGNYRSTLMGVDLNRAWNRISEWIHPTLFATRTLLEGLDKNANAPLDCVIDLHAHTNANGLFVYGNTYDDVYRYERHIVLPKLLAQHTEDYNPDNTMYNQDPHKAGTARRFLCSILSEHVNCYTIQVSMYGYYRKGSPELLPYTEESYYRVGRNLARVLMEYYKLTGLIPSGLPDQPSNKRGRQSRQRYRQPRDPRPRTARTPAPLHLASIHEYFKEDMPELPTGSRYRSMSGTRMNLGAGTASAIGTTSVKNPSYRYRSPGAGPLDAGKSNGLLMMQGHAEPRLAIIDFNQLTRGGLDRATGKNRAKIPRKSPDRFSKFRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HD83</accession>
    <name>A0A8J2HD83_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Similar to Esyt2: Extended synaptotagmin-2 (Mus musculus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">HICCMSTLAB_LOCUS7737</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5095495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HD83"/>
    <dbReference type="OrthoDB" id="1029639at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005544">
        <property type="term" value="F:calcium-dependent phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031210">
        <property type="term" value="F:phosphatidylcholine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008429">
        <property type="term" value="F:phosphatidylethanolamine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061817">
        <property type="term" value="P:endoplasmic reticulum-plasma membrane tethering"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006869">
        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04050">
        <property type="entry name" value="C2B_Synaptotagmin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04030">
        <property type="entry name" value="C2C_KIAA1228"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21670">
        <property type="entry name" value="SMP_ESyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000093">
        <property type="entry name" value="Extended synaptotagmin 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000155">
        <property type="entry name" value="extended synaptotagmin-2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037752">
        <property type="entry name" value="C2C_KIAA1228"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037749">
        <property type="entry name" value="Ext_Synaptotagmin_C2B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051634">
        <property type="entry name" value="Extended_Synaptotagmin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031468">
        <property type="entry name" value="SMP_LBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039010">
        <property type="entry name" value="Synaptotagmin_SMP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45761">
        <property type="entry name" value="EXTENDED SYNAPTOTAGMIN-LIKE PROTEIN 2, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45761:SF1">
        <property type="entry name" value="EXTENDED SYNAPTOTAGMIN-LIKE PROTEIN 2, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17047">
        <property type="entry name" value="SMP_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51847">
        <property type="entry name" value="SMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0106">Calcium</keyword>
    <keyword evidence="8" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="9" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="domain" description="SMP-LTD" evidence="13">
        <location>
            <begin position="106"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="12">
        <location>
            <begin position="276"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="12">
        <location>
            <begin position="430"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="12">
        <location>
            <begin position="662"/>
            <end position="787"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CAG5095495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="796" mass="90042" checksum="B169091F869E3720" modified="2022-05-25" version="1">MGDKEEENKLVEQTEEKITWPYMTIKSFSTSLILKVAAVGAIWGWGYMNWSIGWLLPPVILSVWKVENSRSAELKRLTAQAAVMAREKDIIISRLDELPSWVYFPDFDRVEWLNKILYKVWPGMNHLVRDIVKEKIQPAIVQSLSEYKMTGFQFGRLVLGRIPPKVYGIKVYETNTSRNEIVLDCDILYAGDCDISFSLGNIKGGIRDFQLRGMARVILKPMLNVIPLVGGFQLFFLNNPSIDFNLVGIADVLDFPGFNQALRKVIKEQVSAIAVLPNKIIVPLSEDVPAEVLKMPEPEGVLRIHVVQAKHLMKKDIGMLGKGKSDPYAVINIGAQEFRTKTIDNTVDPKWDYWCEAIINTRSSGLEVAISLWDWDPNFPGVETDDLLGRASIEVSKVKKRGTIDNWFTLEFAKHGMVHLRLTWLNLSKNVADLQAALMETQQLRVTSMSTAILTLFVDSAKNLPCLRGSKQPDVYLEASVGNKTERTATMLRSCDPIWEQGFTFLVGNPETSSLNIRIVDDKTGSVVGTLTYSISILMTKLNLEDMQHPYDLQNADPESKVIMSMSLHLLKYETPEINIDEEEDEEDFSQLQKKIERQESNISFSQSSSVSSSAAIPPVAEVEKNIDSEMIILSESVNSSSTHPQLIQRHFSITSSAGDWKLGRIQLTLRYSVPRQKLVVVVHKVANLPLPLNDPSNIPDPYVKLYLLPDRHKETKRKTAVLKDNCNPIYDEQFEYVVSQGDLNERILEISVCTQKAWLSSSNNIMGQVRINLSEIDVTQAFTNWYDLMPDIKKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HD97</accession>
    <name>A0A8J2HD97_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS5751</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5090798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HD97"/>
    <dbReference type="OrthoDB" id="7690493at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="101"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="180"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="256"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="478"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="831"/>
            <end position="871"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="885"/>
            <end position="953"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1001"/>
            <end position="1022"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1039"/>
            <end position="1066"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="180"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="261"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="478"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="831"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="903"/>
            <end position="919"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1006"/>
            <end position="1019"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1039"/>
            <end position="1053"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1054"/>
            <end position="1066"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5090798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="1148" mass="125938" checksum="A6F548B0E4A8DF3D" modified="2022-05-25" version="1">MVIVRFNSYKKNIASDNIEAISHCLGEYSKSQGSSDNITVIIVFLTPPDQIGAKQFDTHSLSTDVNTINMEVNNRHMSNPNSQYDVDTEFMEQQFFNKNDSAFDDNASYDKSSTISQDGRTLGYEDGKNDDLGPETNVDTLDAGDNCTLVNASRELFSNEKSDNNLTVGNELGDTFSCPSNNTNEHDNITSVDNVGDSDESDDEWNFYRIEPNQETENFLQPKVSSVVSEVGEEIVEPEILENYKDLLSDEKVNFSNQNTDKSEEKESFFSSDKPEINKNNEDLLLPETQDNCSEEMDFSLNPNAAEFVPVSSPPSIPSRFMDLPISGSPLKQTSMMDDINLPSPKEFKEEASHRPHEVEEEDNETISLNGNAFTGENIEEFDEKKKAALNLDESEISSTRAEFGDESNISFLATDFQKASGFDGSFTESCTEYENDPMAMSMGPDGFNLLSNPVDLNAIHDLNDSDLCDINSLGEEKEQTLTPVDDDHSQPLDLKSPDSNELQLKSTPLEHENTNNNILCTLSPSEELNVKDIENNTDEIISQVAAMNLKNEQLSEVCLENTNDFTNNTDNIKNNDQAQDDSPLTEQKPAESLFLESQHVPLENVEIQKPQNKFDSSLENCLISCDESKNLKHHQEEINLTDQCNENTFSDSEKLASHDSINTQVITKSEPAFNNECEFKNEEQEKNKEKDNVPDVSVSDNFTDFLVDIVPTKAQNRENSIIEKENTDITVSPKKSMELSKSLQEFTGLEKELSPTENNKDLMENISHKISEKSQIQDTLTTKDAVVENSEKSLDQTIEPSPEKIKVSAVEAKNTTAVAAKTKSNKISSKTITKTSATKSSTRVTSAASSKPPVGVVSRSTNSSADTKKVTGVGVAGNSIDASKASTLSKPSSKPGIKSAPRLTSVSQSKSSATKVPLTTTNTEKKSTVTTNGDSKANKIPPKSRTSTVDVPSKPLVKSTVSSARLTTTTKSKSSVGTTESKLGLKTTVEVKSSGINIRPKTAPSALTTTKSRTSNPAKPSIVDKNVKETANKQISNRTPITNSRASNQGLHSTTTTVSATTKRSTTTVRTIKQQSSLTRTTAKNIKTSIKTNVNKTQLPNNVNEIKNTKVIEESLSAVTIVNAETVSEKDSSAPTIENQQIIGQEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HDE4</accession>
    <name>A0A8J2HDE4_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to PPP4R4: Serine/threonine-protein phosphatase 4 regulatory subunit 4 (Homo sapiens)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS7422</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5094864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="340346at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008287">
        <property type="term" value="C:protein serine/threonine phosphatase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019888">
        <property type="term" value="F:protein phosphatase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021133">
        <property type="entry name" value="HEAT_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039918">
        <property type="entry name" value="PPP4R4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21467">
        <property type="entry name" value="PROTEIN PHOSPHATASE 4 REGULATORY SUBUNIT 4 PPP4R4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21467:SF0">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE 4 REGULATORY SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50077">
        <property type="entry name" value="HEAT_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="HEAT" evidence="1">
        <location>
            <begin position="169"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="1">
        <location>
            <begin position="208"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="306"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="603"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="705"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="816"/>
            <end position="842"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1058"/>
            <end position="1110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1153"/>
            <end position="1181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="313"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="603"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="648"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1061"/>
            <end position="1073"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1083"/>
            <end position="1107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="1160"/>
            <end position="1177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5094864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="1335" mass="149448" checksum="33F63A423F8901CC" modified="2022-05-25" version="1">MKIKMWQEGGEAPFDELIDSKGDEIQKLSVIQTLPSLLVGDPQTCIQRLMPKMQESLQEASTEFHVAASSTFKTILEQRLVSHSTFTQTFLQSILNSLDSKDQVVADAWLETLLDVIELLPSEVIKREILQVAISKGQLSQPVNSRIICCKLLGKICTRFNSQLIRKQVLPTVHSLCQDVNSDVRACICLQLRFVAEGLGPESVKSALLPSIVELASDEESIVRHASVQTIVYLLPHLNADVIKSTISPLIKKSCDNALKSDVTVMCTIAEEFGKLAIGLEKSLSTSEKTWLIQFFKQLSQVGILPNKDKKPSGSTFNSNNTNSNSSNPGNKQQEFSIINISSSNPTIIEHYVECRRLCAFNIPAMFIFAASTIEDVDSLISTFSELSADPFYLVRRTIACGIHERPMPVKLAAGRTFLVFIRYNLKPVERSELRNKLYSEFARNKSCYIRMLFIRMMIEAMTLYSSMYFKEHFYMVVLSLSEDPIANIRLKLVSLLPTLKSYIRLPSDKKLLSSFESSVRNLMNNEKDRDVISALTTVIRKLDEIDVRHEGQSSSVKLNKQDNDDFKKYEEEKQIMATVSGKLSTGQQVTLIKKSPIAVTGRVNSNDGASSVRNTKQSGISSDNLTKSTISSQKVKQTGSMPLTDSTTFKSRQTTPTTTTTTRSFDLAKASTSSDDLTSSWARLTSNSMLLTHLWEKIDHRGSSKLSSLSAPSSSSSSSSSSSSMTSNQSNFLGIATNNSEETDISSNYYHHPPCNCYKSSIYPSSSLLSSSGNIEMDYKSTEASTCSCRESLSSKLNSTHLYHNHHHHLYNHHHNHHNHHHHHHHHHHHNHNHNHNYHHNQSKSNYLDTNYSSLTTPLVLTRNKDDRHGINQYNNPYKYLNNYLMPRESTQSYNNDDNNKLMPNFAALRAVNNAAQHNSCWGFSSMPEIPVTLLEDEFLVDTGMRIPAQLSSLSQSTSKIPNLQDIIYRNTRIDNYNVNKSRRSNSSSFPCSSTSFNNSGVINIDNKGKSKIHYQLPESCLRRTTSVDKSNSIGNIVGNRLSMSFDETIKINKITINDDNNDDDDDDDNDEENIKSKKYSSKSIIGKRLSSSNRNNSTSKNGTTGESVTITGTSKIIDDKKKKLSFVDRDKNFMPSNTNITNITTAATTTTTTTTTTAGGGGGGGGSGSGSGSGSGTRILDKTKRHSASYSIKFFDSKNYKDKFKRHSLEVPEYSPERGRLKRNYTLDVNHNQGISKIPLRNSILTGSRTAPVTRASSPIRLGPQISYDREKDHQTGNEYHHSDHRVMTRFSSSDEQVDKLCIRFAYVDPYGREENPRKSISKLPVWVPRKKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HE16</accession>
    <name>A0A8J2HE16_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Cc_fen1_2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS7927</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5095876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HE16"/>
    <dbReference type="OrthoDB" id="8124546at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5095876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="353" mass="41720" checksum="A50DCB23261D009B" modified="2022-05-25" version="1">MGINDCYKICHHLIDRAYKRTKEKFYRSKCKIYIDGLSVWFLGYLDDLPNRANAHTKFNAIMSMIRKKNNFTVISTIMYFHGNPPALKDKPVSKHVSTKELLIWCNELLRRESVNEISFLDSGEAESECFFERDEGYASIIVTNDSDILPICYKYQPQSPDDLVFCFLTRKRIFYNTNFLTTKLNKNAFTLLLNLHGSLELIEPLFTFTMTKLMFDILEYDVPIFSKVFQRINFFMEELNEDNIELCIAYFIWLLVQAKIVGYGNFSWPTKESKIVTLNYIQVLEWLIMYSNQGKNVENYDKNFRVETSVRAFYYILRICENVFTELKNVEIENFKQLENIVKEISVDSIIFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HEQ6</accession>
    <name>A0A8J2HEQ6_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS6657</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5093188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HEQ6"/>
    <dbReference type="OrthoDB" id="7699906at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5093188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="72" mass="8284" checksum="8B0F5548BB6443A1" modified="2022-05-25" version="1">MKSYLGLTAHYLKRVEMRTVELGAYHTEERKTIDNLRSKLRKICNDWGLNDDKISTFVSDGRANIKGAIKVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HEZ4</accession>
    <name>A0A8J2HEZ4_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Alpha-actinin, sarcomeric</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">F-actin cross-linking protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HICCMSTLAB_LOCUS8160</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="6">F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the alpha-actinin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5096338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HEZ4"/>
    <dbReference type="OrthoDB" id="18853at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044877">
        <property type="term" value="F:protein-containing complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd21214">
        <property type="entry name" value="CH_ACTN_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21216">
        <property type="entry name" value="CH_ACTN_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00176">
        <property type="entry name" value="SPEC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000004">
        <property type="entry name" value="Actinin alpha 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000001">
        <property type="entry name" value="Actinin alpha 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.60:FF:000005">
        <property type="entry name" value="Actinin alpha 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000005">
        <property type="entry name" value="Actinin alpha 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.60:FF:000002">
        <property type="entry name" value="Actinin, alpha 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.60:FF:000003">
        <property type="entry name" value="Actinin, alpha 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000148">
        <property type="entry name" value="alpha-actinin, sarcomeric isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.60">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001589">
        <property type="entry name" value="Actinin_actin-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014837">
        <property type="entry name" value="EF-hand_Ca_insen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018159">
        <property type="entry name" value="Spectrin/alpha-actinin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002017">
        <property type="entry name" value="Spectrin_repeat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11915">
        <property type="entry name" value="SPECTRIN/FILAMIN RELATED CYTOSKELETAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08726">
        <property type="entry name" value="EFhand_Ca_insen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00435">
        <property type="entry name" value="Spectrin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00033">
        <property type="entry name" value="CH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01184">
        <property type="entry name" value="efhand_Ca_insen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00150">
        <property type="entry name" value="SPEC"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46966">
        <property type="entry name" value="Spectrin repeat"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00019">
        <property type="entry name" value="ACTININ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00020">
        <property type="entry name" value="ACTININ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="4" id="KW-0106">Calcium</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="10">
        <location>
            <begin position="30"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="Calponin-homology (CH)" evidence="10">
        <location>
            <begin position="143"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="11">
        <location>
            <begin position="697"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="11">
        <location>
            <begin position="738"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="264"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="422"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="622"/>
            <end position="685"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00043249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00067262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAG5096338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="843" mass="97466" checksum="5E75D6D23847D99B" modified="2022-05-25" version="1">MNDMEAYGDGYMEPEEEWEREGLLDPAWEKQQKKTFTAWCNSHLRKAGTSIDSIEDDFRNGLKLMLLLEVISGETLPRPDRGKMRFHKIANVNKALDYIASKGVKLVSIGAEEIVDGNLKMTLGMIWTIILRFAIQDISVEEMTAKEGLLLWCQRKTAPYKNVNVQNFHLSFKDGLAFCALIHRHRPDLIDYNRLSKDNPLENLNTAFDVAEKYLDIPRMLDPDDMRTTAMPDERAVMTYVSSYYHCFSGAQKAETAANRICKVLKVNQENERLMEEYERLASDLLEWIRRTMPWLASRQTDNSLAGCQKKLEEYRTYRRKHKPPRVEQKAKLETNFNTLQTKLRLSNRPAYMPTEGKMVSDINKSWKGLELAEKAFEEWLLSEMMRLERLEHLAQKFKHKADAHEEWTTGKEEMLTSQHFRQCKLNELKALKKKHEAFESDLAAHQDRVEQIAAIAQELNTLEYHDSASPFNNWLDGTREDLVDMFIVHTMEEIQGLMDAHAAFKATLGEADKEYNSIVGLVREVESIVKQFQIPGGLENPYTTLTALDLTKKWSDVRQLVPQRDGTLQAELRKQQNNELLRRQFAEKANAVGPWIERQLDAVTAIGLGLQGTLEDQLHRLKEYEQAVYQYKAHLEELEKIHQAVQEGMIFENRYTQYTMETLRVGWEQLLTSINRNINEVENQILTRDSKGITQEQLNEFRSSFNHFDKNRTGRLAPEEFKSCLVSLGYSIGKDRQGDIDFQRILAIVDPNSSGYVQFDAFLDFMTRESTDTDTAEQVIDSFRILAGDKPYILADELRRELPPDQAEYCIQRMPPYKGPNAQPGALDYRSFSTALYGESDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HF41</accession>
    <name>A0A8J2HF41_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS8235</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5096489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HF41"/>
    <dbReference type="OrthoDB" id="8192800at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="309"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5096489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="401" mass="46318" checksum="2E916AFFC6D5AE23" modified="2022-05-25" version="1">MTLHWWMHWFWVTLQFTVIFGIPVSLVKEDPKIKYDSSTVWRSVTEKMTTNSDEILSEVEPTVANMRIAKAINFYQPSMKGNVAVDPSESRPSTNASITIKNTQDNSEYHNNDSIDPYTFIPDERTTNFWSGQTEIQKEELIDDFRIKNDKIYQKRKDTRITWILTTSRPLTRQNHEEKSGDLFPNLSTTEKKDLTVLPLRLEERRIKLIVNRTQITTGDNDETLLNTRIFNSSEDIEIDQELAEPRVSSVTRVPLFADSNRLSRARNAFVSDFRIDRAQDRSSQDNIEEIESEKNIDSINVQSTTFDIAVITGSCLAMVVFLSAMVSFGFIMYRRKYLNPPQTLNSDKCSNPDTSGYIDDSTIQDNSEEMYSLDNDSFLNSLEAMTIQNYWTDSVKHTKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HG34</accession>
    <name>A0A8J2HG34_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Similar to NASP: Nuclear autoantigenic sperm protein (Homo sapiens)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HICCMSTLAB_LOCUS6753</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NASP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5093333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HG34"/>
    <dbReference type="OrthoDB" id="5587616at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034080">
        <property type="term" value="P:CENP-A containing chromatin assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006335">
        <property type="term" value="P:DNA replication-dependent chromatin assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051730">
        <property type="entry name" value="NASP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15081:SF1">
        <property type="entry name" value="NUCLEAR AUTOANTIGENIC SPERM PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15081">
        <property type="entry name" value="NUCLEAR AUTOANTIGENIC SPERM PROTEIN NASP -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 6" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="6">
        <location>
            <begin position="214"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="6">
        <location>
            <begin position="256"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="81"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="162"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="353"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="89"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="103"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="162"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="353"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="397"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG5093333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="407" mass="44839" checksum="2028BB1E047E2413" modified="2022-05-25" version="1">MAENRATNSLENVSYPDAVTAISHGKRHLLVRDYTAAVAALAEGLRILSQTHGENADELGEPYLIYGRALLGLAREEAGILGGGVPGSEEGDNVDSEDEDSSEEKSNDTDEKNGEMLNNPKPDDLNDSNNISIEKKVAIVPGSSKDTTSTIENLNTDVTDRLTLENEKIDENSGMEDDDNESGNGIDLQVAWEVLELAKIVFQKRGSSGLKSLAETYRLLGEVAMESGNHQVAITDLKQALKIFSNEEFFDPRVLAELHYQLGLAYSLLNEFDSSIQQFNKATSLLELKINQLETMKEPPKSDDPFYTVENEIKELKELLPEIQEKITDMTDFKQEACKLVIEGIKNKVTSVPHNGASTSSTMANTAENISSSKESKSVTDISHLVRKKRKSDEPMEQNTSPLKKKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HGC1</accession>
    <name>A0A8J2HGC1_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS8141</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5096300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HGC1"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5096300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="81" mass="8842" checksum="F1A93E5082C7C518" modified="2022-05-25" version="1">MGYDGRGVAEAIIFHTSGHPTFWSWVVYYFSCSPPESTQLRGRGFAKPRRSRGFAGCEGGAARLLQSRGFAGRGGQKKSKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HGG5</accession>
    <name>A0A8J2HGG5_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS9751</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5100678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HGG5"/>
    <dbReference type="OrthoDB" id="10028922at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33053">
        <property type="entry name" value="PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5100678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="172" mass="19587" checksum="E4F538FB79035918" modified="2022-05-25" version="1">MEQITENNTIERPKTFEYVQFHQESGSASSITLSEDLRFWLSENSISQQAANKLIGIFRNHGHQNELKKDVRTLMKTPRDVTGKIVNGNGGSYFHFGITHGLTRSINKYYNVCPATILIQLNCDGMSFSKSSSSQFWPLLAAIKADFYSEPVLVGLFHRYSKPNNFTRNNYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2025-06-18" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HH18</accession>
    <name>A0A8J2HH18_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="19">Similar to Uggt: UDP-glucose:glycoprotein glucosyltransferase (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">HICCMSTLAB_LOCUS8095</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Recognizes glycoproteins with minor folding defects. Reglucosylates single N-glycans near the misfolded part of the protein, thus providing quality control for protein folding in the endoplasmic reticulum. Reglucosylated proteins are recognized by calreticulin for recycling to the endoplasmic reticulum and refolding or degradation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>N(4)-(alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 9A1,2,3B1,2,3) + UDP-alpha-D-glucose = N(4)-(alpha-D-Glc-(1-&gt;3)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:61304"/>
            <dbReference type="Rhea" id="RHEA-COMP:14356"/>
            <dbReference type="Rhea" id="RHEA-COMP:14357"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="ChEBI" id="CHEBI:59080"/>
            <dbReference type="ChEBI" id="CHEBI:139493"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum lumen</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the glycosyltransferase 8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5096209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="27683at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003980">
        <property type="term" value="F:UDP-glucose:glycoprotein glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018279">
        <property type="term" value="P:protein N-linked glycosylation via asparagine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06432">
        <property type="entry name" value="GT8_HUGT1_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000004">
        <property type="entry name" value="UDP-glucose glycoprotein glucosyltransferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040497">
        <property type="entry name" value="Glyco_transf_24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009448">
        <property type="entry name" value="UDP-g_GGtrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040693">
        <property type="entry name" value="UGGT_TRXL_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040694">
        <property type="entry name" value="UGGT_TRXL_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040692">
        <property type="entry name" value="UGGT_TRXL_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040525">
        <property type="entry name" value="UGGT_TRXL_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11226">
        <property type="entry name" value="UDP-GLUCOSE GLYCOPROTEIN:GLUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11226:SF0">
        <property type="entry name" value="UDP-GLUCOSE:GLYCOPROTEIN GLUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18404">
        <property type="entry name" value="Glyco_transf_24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18400">
        <property type="entry name" value="Thioredoxin_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18401">
        <property type="entry name" value="Thioredoxin_13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18402">
        <property type="entry name" value="Thioredoxin_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18403">
        <property type="entry name" value="Thioredoxin_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06427">
        <property type="entry name" value="UDP-g_GGTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="repeat" description="ANK" evidence="12">
        <location>
            <begin position="15"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="12">
        <location>
            <begin position="48"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="12">
        <location>
            <begin position="85"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="12">
        <location>
            <begin position="118"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="12">
        <location>
            <begin position="202"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="UGGT thioredoxin-like" evidence="14">
        <location>
            <begin position="522"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="domain" description="UGGT thioredoxin-like" evidence="15">
        <location>
            <begin position="790"/>
            <end position="919"/>
        </location>
    </feature>
    <feature type="domain" description="UGGT thioredoxin-like" evidence="16">
        <location>
            <begin position="931"/>
            <end position="1177"/>
        </location>
    </feature>
    <feature type="domain" description="UDP-glucose:glycoprotein glucosyltransferase thioredoxin-like" evidence="17">
        <location>
            <begin position="1209"/>
            <end position="1420"/>
        </location>
    </feature>
    <feature type="domain" description="Glucosyltransferase 24 catalytic" evidence="18">
        <location>
            <begin position="1716"/>
            <end position="1983"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1987"/>
            <end position="2013"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00045874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF18400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF18401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF18402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF18403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF18404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="CAG5096209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="2013" mass="231099" checksum="4DAE892508A5F721" modified="2022-05-25" version="1">MTSTEQVYPISNNNHSLNQLHDAVRLGKYDIVKKLVLDGVDINSRGRCGSTPLHLAVKYEHLNIMKYLLKNGASPESKYSSPHYAEWTPLHFACGLGRLKSAKLLLLHGANVNPNNVDDVHPIHVAVTKLDHRMINLLLENGANPNARFRDNFFTRNGGVVPSTLKHFNYVLLFYPVSMGSVDVAKLLLKYGANVNGKSTESNRTLLMEAGHKNNLEMVQLLLENGASVNDYDVHGGTALFYTLLDRCVLHYQFVKSYDQTKKLKLMKLLLRSGANVNISVQNRTILDIAVVSGLRDICTYLADNRIIPEIRDDIEYLNKHRRNLIEIRYDLISEWYRRHMIGMSVEDISSEINNPEWFNYDVSNQEHERRIKLIKEQIHEILNDLKCEIIDGTNISLFNILTINKRGLVKLAFNKKLRRFCLRDYKNKYFMYYSMLKTRLNYAIQKSLLIEKAIKSIYNVLCSQIPQDCCEEIVAYLNDEDLNMWYFRIICLLLISSCISSADKKHNKYVTTLIDGKWKDTPIVLEVSEYLNDENSNLFWSFVDLICKQEDGFITQDRIFELNDFFPVGTDKEIYNRVVKLAETLVTPTGLPVLKLSLSLRIYSARVEMFSQMAVNKENIPDCNNFIDVGGNTFTCSADQVEELINNSEDNLHTYSVDHQYPGSRGSSKTNKNVILYGQMGSSGFKSLHDKLKSLAESDKITYILRHYVKDRPDNKLRLSGYGVELQMKSTEYKATDDSDIKESSGKESEEINEGVEEIDGINFGVLKKLYPEKKSQLDELLTHLLDTSDEVSALKVWQFQELSHQAAERIMKSPPSEAVKVFTDIAQNFPMQAKSLIRTKVSNEMKKEMKRNQEIFFGNLHIQPTETVLFINGLYFDIDVIDILALLEALRSELRVMEALLKIGFSNKKMDKLVALDLSSNLDNQDFAIDIRDSAIMWINDLETDKRYQKWSSALTLLIKPMYPGTLRQIRRNFYNLVLIINPLSDKIKHLLNTIDTLNKHSAPIRVGFVFVTNFNTSATGFTDPSVAVNNAFHYLTEEKNQFEAFKFLLTLQNYISGNSIDVTDVKKALKIRDPSADIDDIFGEDSQYDVGRHLAMDFVKRTGFKTFPQVLLNGVPLASSEDADTFEETVLTTIMTQTPMLQKAVYKGEVVESDDIVDFMMSQPNVMSRLNDRILQPENSKWLNLIGNLPKNQEISNWNQQDTATWLMKNSNYLVMPRRVDKQHLYTYWVAADFETVKGRQLLREALKYLDGNTDVRITIIVNNIDKSNDPLVNINMIVLAAMEMLPQKKAVKYINNILQEDNVALIKIGKFDFGEDSINEKLSEQEFKIKVHKYYAKTALKLMPGDRAVVCNGRILGPLDEDEEFTRDDFSLLERFSHNTYGDKLMKSLQVIQSTDDDDDDTEISDDVIMQITSLLVLRPQTQSRYDIPYSGDEHSVIKVPAAKSNEAAFNLIAIVDPVSRGAQKLGAILSTLQQSLNCNIKIFLNCVDKNSDMPLKSFYRFVFDPELQFNADGQLVGAQAKFTKLPTSSLLTQYMHTPENWLVEVVKSLYDLDNIKLDNVAMGVHSEFELEHLLLEGHCFEASMGNPPRGLQITLGTEKQPVMVDTIVMANLGYFQLKANPGEWLLRLRQGRSADIYDIHSVTGQDVIQDSNEVKVLISSLKSHVLKLKVSKKPDKMHTDLLADDDSQSGIWNSISRTFGSDDTEEKDEKINIFSLASGHLYERFLKIMMLSVIKHTKSPVKFWFLKNYLSPTLKDFLPHMAKEYGFEYELVQYKWPRWLHQQTEKQRTIWGYKILFLDVLFPLDVKKIIFVDADQVVRADLKELVNLDLEGAPYAYTPFCDSRKEMEGFRFWKQGYWRNHLQGRSYHISALYVVDLKRFRRIAAGDRLRGQYQALSSDPNSLSNLDQDLPNNMIHQVAIKTLPQEWLWCETWCNDASKKTAKTIDLCNNPMTKEAKLQAAMRILPEWIGYDEEIKNLQQKVENESKQLEKEERDEHDLEDSLKHEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HHP8</accession>
    <name>A0A8J2HHP8_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Similar to moody: G-protein coupled receptor moody (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HICCMSTLAB_LOCUS7918</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5095858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HHP8"/>
    <dbReference type="OrthoDB" id="10044919at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15210">
        <property type="entry name" value="7tmA_GPR84-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24228">
        <property type="entry name" value="B2 BRADYKININ RECEPTOR/ANGIOTENSIN II RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24228:SF63">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR MOODY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 10" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 10 13" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 10" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="24"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="64"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="106"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="156"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="220"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="252"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="12">
        <location>
            <begin position="7"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAG5095858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="318" mass="35726" checksum="4E9F7F1D0EDC9DF5" modified="2022-05-25" version="1">MITGLIGNLLTIVALCKYPKVRNVTAAFIISLCVADFIFCVLVLPFDSIRFVNSGWTDVRFLCVLVPFLRYGNVGVSLLCVGAITVNRFIMISQNSLYGKVYKKHWIAVMIAFCYLFSYGMQVPTLVGAWGEFDYDSNLETCSIVRDSRGRSSKTFLFVTGFVIPCIVIVGCYAKIFWVVHSSESRMRKHASPTIKSPHTPGRDTREIKQKRSEWRITKMVLAIFLSFVACYLPITIVKVADPEVRYPGFHVMGYLLLYFASCVNPIIYVIMNKQYRQAYAGVISCSKIRASLTPHGSSNPGQNNYGQGNHIVTVTKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HHP9</accession>
    <name>A0A8J2HHP9_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS9080</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5099470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HHP9"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5099470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="70" mass="8278" checksum="6E07FDB5B6531D53" modified="2022-05-25" version="1">MSANTLRTYVSWTTITIFVGFRSWLEIFPVFINFSVYFTEEENTYGKLLRLDNIDLLGDDDSSWDLMNVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HI46</accession>
    <name>A0A8J2HI46_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Similar to GRINA: Protein lifeguard 1 (Homo sapiens)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HICCMSTLAB_LOCUS8157</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the BI1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5096332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HI46"/>
    <dbReference type="OrthoDB" id="7933078at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd10428">
        <property type="entry name" value="LFG_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006214">
        <property type="entry name" value="Bax_inhibitor_1-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23291">
        <property type="entry name" value="BAX INHIBITOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23291:SF47">
        <property type="entry name" value="TRANSMEMBRANE BAX INHIBITOR MOTIF CONTAINING 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01027">
        <property type="entry name" value="Bax1-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="114"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="148"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="173"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="203"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="234"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="258"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="295"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="11"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="21"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAG5096332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="321" mass="35341" checksum="734BB952FCE63424" modified="2022-05-25" version="1">MSNWQSPPPGAGFYPGQQGYPYPPQNPGYPPNPGYPPNPGYPPPQGDWNQAPPAGFIPTGGNYGQGPPPIPPTAAFGQAPGMYGANYGDEALHDEPKGFDFSDKTIRQGFIRKVYAILMCQLLLTLGVIALFLYHIPTKRYVQEHQGIFWAALVLMLVSLICMACCTNVRRKAPMNFIFLFIFTSAESFLLGTLSSRYESQEVILAVGITAAICFSLTIFAFQTKWDFTGMGAALFVAVMCLMLFGIIAMFWHGKTITIVYGAVGALIFSLYLIYDTQLMLGGKHKYSISPEEYIFAALNLYLDVVNIFIYILSIIGASRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HIK8</accession>
    <name>A0A8J2HIK8_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Similar to Chd7: Chromodomain-helicase-DNA-binding protein 7 (Mus musculus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">HICCMSTLAB_LOCUS8448</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5096913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5857104at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000791">
        <property type="term" value="C:euchromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140658">
        <property type="term" value="F:ATP-dependent chromatin remodeler activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034728">
        <property type="term" value="P:nucleosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd18668">
        <property type="entry name" value="CD1_tandem_CHD5-9_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18663">
        <property type="entry name" value="CD2_tandem_CHD5-9_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17995">
        <property type="entry name" value="DEXHc_CHD6_7_8_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.40:FF:000001">
        <property type="entry name" value="chromodomain-helicase-DNA-binding protein 8 isoform X4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10810:FF:000003">
        <property type="entry name" value="chromodomain-helicase-DNA-binding protein 8 isoform X4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000015">
        <property type="entry name" value="chromodomain-helicase-DNA-binding protein 9 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051493">
        <property type="entry name" value="CHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023780">
        <property type="entry name" value="Chromo_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46850">
        <property type="entry name" value="CHROMODOMAIN-HELICASE-DNA-BINDING PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46850:SF1">
        <property type="entry name" value="CHROMODOMAIN-HELICASE-DNA-BINDING PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00385">
        <property type="entry name" value="Chromo"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50013">
        <property type="entry name" value="CHROMO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Chromo" evidence="11">
        <location>
            <begin position="1672"/>
            <end position="1728"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="12">
        <location>
            <begin position="1773"/>
            <end position="1947"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="13">
        <location>
            <begin position="2084"/>
            <end position="2255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="26"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="183"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="393"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="484"/>
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    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="616"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
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            <begin position="650"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
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            <begin position="826"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1130"/>
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        </location>
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    <feature type="region of interest" description="Disordered" evidence="10">
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            <begin position="1508"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="2363"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="2500"/>
            <end position="2532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="40"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
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            <begin position="183"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
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            <begin position="227"/>
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        </location>
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    <feature type="compositionally biased region" description="Basic residues" evidence="10">
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
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    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
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    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
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    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
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    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CAG5096913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="2599" mass="292451" checksum="29CE0C1BF9E67FA6" modified="2022-05-25" version="1">MDSYDLFGEDVSGSMLDALPDLGGNDHFDPASATNPVVTSRDGSNSGSNRGGSYINSSYSISQESPLQKLASFGGAEFNNSNQLQNPSQRTMFNQNLGTFDGNPAQRTMVPGSFQNQNRSIMPQHRGPHPIAGSQYSNYSDNMYSMEQQHPMARASMNMDPSMQSWSGSSSSYTQLQRHYNQMAPQPTSYRQHMSQYSQPQDQSGMNQKIPPQHFGPQQGMLGNLSVPHQSMQSGSSNVVYQHMVSQQQHYPQSNSAGLYHTSTGFSGFAPTMHQQQQQPSSQQPQRMPHHHPSLVTHQSHPSHSQYPQHSQQHPGSQQPSLDSQYPHHTSPIFNQPQHTGAQHSGPQHTSPQLPGTQHSGQPHTTAQHTGSSTQFGPSKLATSPQYRAAFPQLSPQMSPRPQMSPRPSPVQQQMSPRPIMSPVKPTTLSPHSQVQMTHQQQSNQPSSVSVSPCPSSSMVLNSAIAPQQSNLQALEQMVIPGAATTNSSKPTQDYTQFPTRPPISHSSNLITSVQNSMTMMPNPRMPVSSPWPHSQSQQALHSQPPHQQLSPSETQSQQQTQSQHQLQTHSQAQTRTSINVNDNRNIIDSQSNSMAEQVPMFPLNSNENMHNIVESTRDSSESISTTVVGSSSQESEIVDQSVVKQNLKTHNQSTQDPLLNKSTQQVEQTSTMKTLEVESVQSLPASSTSGNIECNSPSSMVTLQSSNDASSSVIASGEDNEASHSKVNEQSGLNSYQNLPTSEAPAITSSQPSLVSASQPQQFHSEQSLISQSSTAHQVQSQTEQQSHQSLSNHAQHLSMNQTHIQSQSGLSSQQLNPTGQLQIVQPQRDQQSTADLHPSQSQINQPSQLLFQQQQVLSSAPQPPNSVNVSQISQTQQLLTTQIQNTQLPPTPIGPMNQQLSPQSLIPQSTQQPQLHLQQSSMIGQTQPQQSIITQQVNINSNNGTSSQLQVTHSMQSTHTEVQSILPPVVQSTNIGVSSQQTATASVSNTQLPHSVQSGFGEYINVQKSNVMYSNDMVVGSAQPQYPAGADNAGNKAVPKIYAMSPTPTSNAIGGLSSSTSTTHHHERAALQQQLQELFCLSPAPENQEKISHLQEKLQALQQHETNDQCHGGSQCIFQTPTFNSVVVDSPQVSSTTGRGRSKGTPRTKKNRKKVNKEVTTPDFTQSVSQPEQPVSENLVTPGDSSNIVDSVADFEDNKPSSGNTEEEWNKNRKSRQPRKPRKPKEVKEKSVMKEPKSCKEIKPKGRKKKDKEGKECSRRGRKKTIHSDSAEEETGREIENVSDSKSTPDSNVKLTDAPIQDDQEHVDSSTVEPIVTERDEDDEDKVNSEEVNETVKKKDSQKITESTPVKKKSSRKRSVGSKSTARSPRTSKKRKNRIAPDSDGEELAATPPPSPEAGEDANKRRSARNTHRKKYIDDVMLRFSDDEVPLSDSNAIKKLEGSQLKLTSTKKDSETTEITLNKPNFVYINTTDEDSMVVQHILCMRIGKREIKELVSTEPKVEDINVEKNSTTQAIPEDETETSQIPGKSSKISDNPTKSIESNEEKEENENPKVVEEVSNKEIVEDEQSNKSIDGEKPEKSDHEKEESQEVDGTKSSIAETKSRFIEVEEYLVKYRNFSYLHCEWKTEEELYKGDKRIQAKLKRFKQKIQQSTNIFENTEDDPFNPDFVEVDRVLDEATHTDPTTGETVRHYLVKWRSLQYEDSTWELEEDVDPEKIALFHKFNKLPPKDQWKPKKKPNASLWVKLTDSPIYKGGNRLRPYQLEGLNWLLFSWYNVHNCILADEMGLGKTIQSLTFVEAVYKYGIRGPFLIIAPLSTIPNWQREFEGWTDMNVVVYHGSAASRTMLQEYEVYYKNDKGQQIKDLIKFNVLITTFEFIITDFNELKGYNWRLCVIDEAHRLKNRNCKLLEGLRQLNLEHRVLLSGTPLQNNVNELFSLLNFLEPNQFSSSEAFLKEFGNLSSESEVNKLQLLLKPMMLRRLKEDVEKSLAPKEETVVEVELTNIQKKYYRGILERNFSFLAKGTTSANIPNLMNTMMELRKCCIHPFLLNGAEDQIQLDYKDKEDSEAYFHALVNSSGKMVLIDKLLPKLKSSGHRVLVFSQMVKCLDLLEDYLLYKKYPYERIDGRIRGNLRQAAIDRYSKPDSDRFVFLLCTKAGGLGINLTAADTVIIYDSDWNPQNDLQAQARCHRIGQQKMVKVYRLLCRNTYEREMFDKASMKLGLDKAILQSMNTTQGGKDPGNKQLTKVEIEDLLKKGAYGAIMDDDNAGDKFCEEDIDQILERRTQVITIEAEKGSTFSKASFACSSNRSDINIDDPDFWKKWAKKAEIDTTEKKEEEDLVISEPRRRTQIKRYGHDESVVDMSELDSSDDSDDDNTGLSGRGKKRRDKFGKKNRKTCDEYVPREGEVVYGNWARSECFKVERGLLTYGWGRWEEILQNSQFRRGWRDIDIEDCARVILLFCLRYYRGDEKIRHFIWDLITPLENGQKIKSACTSTCNRNNRQKKKSRVREGRETRGSGVNSGPNDPNHWSHAEKYDGDIFLESAYKKHLSRHATKVLLRVRMLYYIKHEIIGDLVQHISDGVHVRFVKIHCFIFYML</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HJ73</accession>
    <name>A0A8J2HJ73_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similar to gdl: Gonadal protein gdl (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS9458</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the gonadal family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5100247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HJ73"/>
    <dbReference type="OrthoDB" id="21617at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010849">
        <property type="entry name" value="Gonadal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13054">
        <property type="entry name" value="DIGEORGE SYNDROME CRITICAL REGION 6 DGCR6 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13054:SF2">
        <property type="entry name" value="PROTEIN DGCR6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07324">
        <property type="entry name" value="DGCR6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5100247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="174" mass="20104" checksum="A32A835B28C3434A" modified="2022-05-25" version="1">MELSDPSPEDLQRKLYFLVEQLQNMASALPSKYQMRLPYELLSGLANSLLNDTIFEIVKGLMEIQHVTEKHLFQQRLQLLNQQKIQMQEVLAGSNTEEEKIAVKIALEEKQKKDLKATDMRLVMQLDQKVADQQSTLEKAGVPGFYVTNNPAEIQLQMRLCDFIIRLSKMEIPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HJE8</accession>
    <name>A0A8J2HJE8_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Similar to DCAF12: DDB1- and CUL4-associated factor 12 (Macaca fascicularis)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HICCMSTLAB_LOCUS9581</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the WD repeat DCAF12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5100492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HJE8"/>
    <dbReference type="OrthoDB" id="9610195at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080008">
        <property type="term" value="C:Cul4-RING E3 ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:001037">
        <property type="entry name" value="Blast:DDB1-and CUL4-associated factor 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056151">
        <property type="entry name" value="Beta-prop_DCAF12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051191">
        <property type="entry name" value="DCAF12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19860:SF16">
        <property type="entry name" value="DDB1- AND CUL4-ASSOCIATED FACTOR 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19860">
        <property type="entry name" value="DDB1- AND CUL4-ASSOCIATED FACTOR 12-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23760">
        <property type="entry name" value="Beta-prop_DCAF12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="5 10" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="DDB1- and CUL4-associated factor 12 beta-propeller" evidence="11">
        <location>
            <begin position="102"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="10">
        <location>
            <begin position="209"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF23760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAG5100492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="459" mass="52061" checksum="CB6035E0129844E8" modified="2022-05-25" version="1">MAETMRMRVYGKHPTCANLTRLEERRSRRLALRLDRNRKPDKPEDFVCYESSDDEEETVMEGRQYLKTSFNFVDYVRARETNTKEVRKINQEYGSRHILTHDLFKEYPITLTNMNKVFCSQWLSDRQVVFGTKCNKLMVYDVATQKLDQIPSLYGRNSSTNNASTAEQQSGIHSVQINPSRTLLSTGGRNCNEIAIYRLPTLDPVCVGENGHRDWVFDMCWLDDEFLVSGSRDTKMTLWHINNELATASDKADVPKPESIQPVCVKECRSAQKVRALVFNKAINEIAALSLNCYIHIWSAETFKQKISRKLPACQENVCLAVQDGGVYAVGCRSYTLLLDARTLQPIKKIPSRYTGCGIRSASFQGSVLTIGTGLGMLMFYDVRAQKYLESSINSNRTVVLKASKGYVFPDEEFMDGVQNVKYTPAIYTHCYDASGTRLFTAGGPLPANFYGNYAGLWQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HKA5</accession>
    <name>A0A8J2HKA5_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS9781</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5100708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HKA5"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5100708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="151" mass="16784" checksum="207EB99579D5A79B" modified="2022-05-25" version="1">MTLISNKLRRVSGNPTISPIPSLPPVDDSSTPKIQIIADYLVDTFASNSSDTNYSAAFLTINKLLLWFEKSGFKFSMTKSQFMLFSKGYSINHNALNFQSDEDTWTNIDNKLITLRKLYPIQNMAIRTATGAFKTSPASSLQAESDIPPLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HKE0</accession>
    <name>A0A8J2HKE0_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Similar to Foxk1: Forkhead box protein K1 (Mus musculus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HICCMSTLAB_LOCUS9856</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5100783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HKE0"/>
    <dbReference type="OrthoDB" id="691130at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd20054">
        <property type="entry name" value="FH_FOXK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22688">
        <property type="entry name" value="FHA_FOXK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.200.20:FF:000031">
        <property type="entry name" value="Forkhead box protein K1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000030">
        <property type="entry name" value="Forkhead box protein K2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047394">
        <property type="entry name" value="FH_FOXK1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001766">
        <property type="entry name" value="Fork_head_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018122">
        <property type="entry name" value="TF_fork_head_CS_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030456">
        <property type="entry name" value="TF_fork_head_CS_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45881">
        <property type="entry name" value="CHECKPOINT SUPPRESSOR 1-LIKE, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45881:SF7">
        <property type="entry name" value="CHECKPOINT SUPPRESSOR 1-LIKE, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00250">
        <property type="entry name" value="Forkhead"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00053">
        <property type="entry name" value="FORKHEAD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00339">
        <property type="entry name" value="FH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00657">
        <property type="entry name" value="FORK_HEAD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00658">
        <property type="entry name" value="FORK_HEAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50039">
        <property type="entry name" value="FORK_HEAD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="FHA" evidence="8">
        <location>
            <begin position="57"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="Fork-head" evidence="9">
        <location>
            <begin position="270"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Fork-head" evidence="6">
        <location>
            <begin position="270"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="169"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="215"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="400"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="504"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="170"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="215"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="411"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="534"/>
            <end position="551"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAG5100783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="551" mass="60599" checksum="F9D937C91F610E23" modified="2022-05-25" version="1">MSSTYSRTQESDAWALLALKSAPASPTRMQWNPETKSAPIARLEGREFEYMVRQRRIIIGRNSSRGEVDVNMGHSSFISRRHLEIFYDHPYFFMTCNGKNGVFVDGVFQRKGAPAFQLPKTCIFRFPSTNIRLVFQSLVDDQDQGNVRDESPPKQRALLPPLRINIPDTGYSSPFPSPTGTISAANSCPASPRAGQSRRNISADLQMVAAYAAAVAGDPQNSNNDRQDSGQSSSRQMSPESGSDSRYRNSNASASNGTSGHYSSSKDESKPPYSYAQLIVQAIASAQDKQLTLSGIYSYITKHYPYYRTADKGWQNSIRHNLSLNRYFIKVPRSQEEPGKGSFWRIDPQSEAKLIEQAFRKRRQRGVPCFRAPFGLSSRSAPASPSHVGLCGIMTPECLSREGSPGPESYPDSSVSSPAGQLSSQSAPGSPGHPYVPPPATSNKNRLVQQITVVTNGDASREDKYVMSGNLMEEQMLSPVGQYSPAPVIVQTYNYSGTFVGPDTNVGMSKRTHEEPDSSPGSPAPLSIVESPEPSDHQQQKRQRVNDVDEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HL13</accession>
    <name>A0A8J2HL13_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="16">CYP6AQ20</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">HICCMSTLAB_LOCUS12017</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Microsome membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5104468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HL13"/>
    <dbReference type="OrthoDB" id="2789670at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11056">
        <property type="entry name" value="CYP6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000042">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050476">
        <property type="entry name" value="Insect_CytP450_Detox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24292">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24292:SF45">
        <property type="entry name" value="CYTOCHROME P450 6G1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 13 14" id="KW-0349">Heme</keyword>
    <keyword evidence="10 13 14" id="KW-0408">Iron</keyword>
    <keyword evidence="12 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 13 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0492">Microsome</keyword>
    <keyword evidence="11 14" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="9 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="13">
        <location>
            <position position="454"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="non-terminal residue" evidence="16">
        <location>
            <position position="512"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CAG5104468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="512" mass="58747" checksum="3BDB2ECFD28351AD" modified="2022-05-25" version="1" fragment="single">MGFITRYWVLDSVFLLASLIFVGYLYMTRKFKYWKKRGVAEIPPTPFIGNFGTCMMMKRSGGQWIQDMYEWSTGLPYMGYYVFDRPFFLVRDPELIKNILVKDFNYFNDRFAKASPHDRIGDANLFLIKNPLWKTVRAKLTPIYTSGRVKKMFELMVDIGDDLISLMKTYNTKGNGEILEVKDLAARFTTDLIATTAFGIRANCLNHPKAEFREYGKKIFAQTMYRNFEFMSIFFAPQIVGPLGLEILPRDVSKFLRSTLWNVINEREKTGIKRGDLIDLLIELRNNKTEIFDGDFGNSLIDNLLAQAVVFFNAGFETSSSAMSFTLYEIALQPEIQNKLRAEINKGLEQTGGKMTYDLVRNVPYMDMVIAETLRKYPPLPVLDRVANENYKVPNSNLVIEKGTPITIPVSGLHYDPEYFQNPEKYDPERFSDANKKARKQCVYLPFGEGPHVCIGMRIGLLQTKLGLLKLLPKYEFTPCKETMVPMRFSTKSLVVAPDGGLFLNVKEIKTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HLH7</accession>
    <name>A0A8J2HLH7_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS12722</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5107384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HLH7"/>
    <dbReference type="OrthoDB" id="8251120at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00030">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2" evidence="2">
        <location>
            <begin position="25"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="141"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="141"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="166"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="187"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5107384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="409" mass="45967" checksum="D4CF05C79168C682" modified="2022-05-25" version="1">MAIAKIKSFLDNSLKSVTTPLDRTTTLEPEIGIRIIHSPYDKTLRVTVLGARHLPQNFGFTRVNSYVVKVKFFPGKEKFETTSKNESWPQWNEEFTFHLRKETKIKFGKSKVTEEFLDGSKLIIATLYAILEDKPLIATDKKEAEKENSKEGSKDGKKDGKKKEGATTSGSQESKSNKLLGQLFSKSSDKEKDKEPVVEKKSIDKRRTVGATTISLDVKNFVTKPPKAKHSDEVSTGDIWKPLRPIASGISGAEDRRESKKGQVEMILVQEKSDKKDVSEGRLILSLSRLRCSLQTMHEQESLKGQLYIKMSVVDGGRVTHFWKSDRFNPCVSMKFAQDQAQVIAENPYEGALKDVSFVVKFVSKNKIGKKTTIGHFVIGPDVGGTYSEQWKQAMAKPGNVVTKWQVFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HM80</accession>
    <name>A0A8J2HM80_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">C-type lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS12485</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5106888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HM80"/>
    <dbReference type="OrthoDB" id="7357196at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00037">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C-type lectin" evidence="1">
        <location>
            <begin position="5"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5106888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="84" mass="9941" checksum="00DCBBEF162678A2" modified="2022-05-25" version="1">MNWCIDHLLRGSEEELFLGIHNYFRGDWVSVSDTDVEKMKHLKWSKKEPDEYRSYNCAIINPKNKLVSRESCTVDHPFICKVPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HMD9</accession>
    <name>A0A8J2HMD9_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cc_odve66_14</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS10714</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5101836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HMD9"/>
    <dbReference type="OrthoDB" id="10527949at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5101836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="272" mass="32626" checksum="030AC9EBA648080B" modified="2022-05-25" version="1">MAIKIDEKQIVLIIQICILLGVSIVLIIVICRPVYVPEVSKYEKLLRELGSTRITAQDLKIVERFKTDRENYFVTEKLVWNNDVDKFISVCDFATRILKVYNNYRNEDIYLLLVTDIINKIHQLVFKERKNEILKKENDYQAIVYLARLFNTFEYIADDKYKTTKSICHDLIIDLLPEFNYIRILGIWFNTENIIYTIIPRLLTHYLEPDKKNFIYDVKENKALTILEEKFSEIHSFADKREKIYLYDYHYVIYQIFKEKQQVGYLTKLFGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HNJ1</accession>
    <name>A0A8J2HNJ1_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Similar to Tret1: Facilitated trehalose transporter Tret1 (Bombyx mori)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HICCMSTLAB_LOCUS12777</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5107505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6133115at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000218">
        <property type="entry name" value="facilitated trehalose transporter Tret1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050549">
        <property type="entry name" value="MFS_Trehalose_Transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48021">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48021:SF1">
        <property type="entry name" value="GH07001P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="52"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="86"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="121"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="239"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="273"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="297"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="381"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="420"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="447"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="481"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="548"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="611"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="641"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="665"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="699"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="723"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="807"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="847"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="873"/>
            <end position="895"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="907"/>
            <end position="931"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="943"/>
            <end position="962"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="974"/>
            <end position="994"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1024"/>
            <end position="1045"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1065"/>
            <end position="1087"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1094"/>
            <end position="1112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1118"/>
            <end position="1141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1153"/>
            <end position="1171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1177"/>
            <end position="1198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1261"/>
            <end position="1281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1301"/>
            <end position="1320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1327"/>
            <end position="1349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1361"/>
            <end position="1385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1397"/>
            <end position="1416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1428"/>
            <end position="1448"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="147"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="573"/>
            <end position="998"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="1027"/>
            <end position="1452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAG5107505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="1488" mass="164324" checksum="EE0F26F921EDE230" modified="2022-05-25" version="1">MLTQIQVTIMNLLDLVINISFVSIVSTLLATYTTGKFGRTVSFYDHASISQYLYLSIVLAIVYQFSLTIGVVSIPSTLVSEMYAPIVKTFGVCIGSGIFYVFAFAASKSYQLMVGLLTEKYVFWIYAVLVIFTRLYTIAAVVYGRNVYFIKLNAGLVAGWSSPYLAKLNAIKYPNSELPLSDIDASWIASLPNLARPCGAIFGGVLVYVIGTKLSMLLSGVGFALGWLCFFVIDSLPLVYVSRVVSGIAVGMLFSVSPLYIGEIAHPKIRGALIALTMQGFLVGTLCGSIMGKYLNMWVFAAVSLAINIIFLISFSVMPQTPYHLIRCHKLEEAAKSILFYDRKAHVKKELDTLQAFQQANQSTTFKSILHELSTPVNRRALLMVNIIAILAQVSGSNVFSSYMEIILTNAHVDIIEPSSLVIVVSLVSILSSFLGMLTYDKYGRTIMLSSSSMGAAFAIFLMGLNYLLLDLNFRNPNLQWLSIVSIILYKIAGSFGLTVVPSALTSEIFAPSIKGVGSCIKSSLIGISAFSVTKSYQPLVKILTEKYLFFIYSLLLILLALYSIYFIPETKVFLMTLVTGLVAGWTSPYITKLDAATHPDSELPINETEASWIVSLINISRTGGSILSAIFVYSIGTKSTALVSGIPLAIGWICFFIMNSVTLVYVSRILSGIGIGMYYSSFSLYIGEMSHPKIRGALVTFNVQGFLMGNLCGNIMGKYCKMWLFAAVSLVFNVIFMVLFSMMPHTPHYLIRCNKMDKAVESISWYNSTADVTNELKALEQFLSVHQSHSFWDEFRALSQPVNRKTLLMIIIITVCTQLGGPYAFSSYMEIIVTNARLDIIKPSDLIIGVSVIGIVSSWLSIYTIDRWGRTIMLLISSIGAAFAMFLIGLNFQLLDLDYSDSRLQWLSITGTIMYRIMSSLGLLSVPATLASEMFAPNVKSVSSCIININVGIFAFTASRSYQPLVSILTEKYVFWIYTLLMIVTGVYTIIFIPETKDKTLTEIHEMLSSGKKLEKVKGSNKYNGVFLLSVMVGSIAGWTSPYLAKLDAQENPNSELPIDKVEASWIASLINLSRPAGGILGALLVHIIGTKLSSLFVGVPIAIGWALFLIKNSVTLIYVSRTLHGISFGMFFSCFPLYVGEIAHPKIRGALIALVMQGLMVGNLCGTVIGKFVDLWMFAAIILVPNLIFLSSFCIMPHTPHYLIRRNEIDKAAKSIEFYDRNTDVKNQLEALKEFIQSSKSLTFRDTIRELNTPVNRKALIMVNIVFAFFQLSGNYTVNAYMEILLTNARINVVVPSDLVISGNVLSIVSSWISIYTNDKYGRPVMLLISSVGVGIGMFLWGLHYQLLDIGYTNPNLQWISIIALVVYQLSVPLGLIPVPSTLISEMFAPSVKNLSASISSVISGLCAFAASRSYQPMVDALSEKYVFWIYSFLMFSSGLYSIIFIPETKGKSLAEIQEILSRDIKAKSNKEDKSNDDDNRVIKKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HNM9</accession>
    <name>A0A8J2HNM9_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS11158</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5102736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HNM9"/>
    <dbReference type="OrthoDB" id="7699256at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5102736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="188" mass="21674" checksum="C76030E06A49F02C" modified="2022-05-25" version="1">MLNKFVDEVHERIMIHTNHAVNEGHKQIKIIGEDSDCVALLSQNWKTWATQGLTELWYEYTCSYKKKVIGIHILAEKLPPELLLTIVAVHNLTGSLYTSRIGTKQAAINNNPMEYLSICGKGWEYHHGSSFSIQNLSATSASIRLHILRAWYITYKQLNLLNYFYQVPLNFTDFGYEIIKNEICPKKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HNU5</accession>
    <name>A0A8J2HNU5_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS11899</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5104232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HNU5"/>
    <dbReference type="OrthoDB" id="8815311at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5104232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="215" mass="25453" checksum="F18208AE46D342F7" modified="2022-05-25" version="1">MVVYLAAAIQEELYSGADWIPKMCECLQNVSVTFPMTTSDLSFRNWSYSSLARNVERNLRVDNLCELLRIKNQFKPGDWRIVETWPKLDITIERVLENHEDIYVVHREGERFEGSEDRRFVFKLVSDDIEDYVNNPRTSFPEDMVLKIKDEEELNRGEHLADRDERLAQTLPKFCDTVWVADKDNINVWKAVLMVLTDRKLYLIERVSPIKFLIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HP77</accession>
    <name>A0A8J2HP77_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Similar to CDC73: Parafibromin (Gallus gallus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HICCMSTLAB_LOCUS11568</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CDC73 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5103555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HP77"/>
    <dbReference type="OrthoDB" id="2186602at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016593">
        <property type="term" value="C:Cdc73/Paf1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000993">
        <property type="term" value="F:RNA polymerase II complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032968">
        <property type="term" value="P:positive regulation of transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11990:FF:000002">
        <property type="entry name" value="protein CDC73 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11990">
        <property type="entry name" value="RNA polymerase II accessory factor, Cdc73 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007852">
        <property type="entry name" value="Cdc73/Parafibromin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031336">
        <property type="entry name" value="CDC73_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038103">
        <property type="entry name" value="CDC73_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032041">
        <property type="entry name" value="Cdc73_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12466">
        <property type="entry name" value="CDC73 DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12466:SF8">
        <property type="entry name" value="PARAFIBROMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05179">
        <property type="entry name" value="CDC73_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16050">
        <property type="entry name" value="CDC73_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Paf1 complex subunit Cdc73 N-terminal" evidence="8">
        <location>
            <begin position="1"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="domain" description="Cell division control protein 73 C-terminal" evidence="7">
        <location>
            <begin position="348"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="118"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="262"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="269"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF16050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAG5103555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="511" mass="58187" checksum="67C10BE414C53DBA" modified="2022-05-25" version="1">MADPLSLLREYNVNKKEIKERGDKIIFGEISWPKNIKTNYLAYGSSKEGTEKTYYTLECLIFFLNSVQLTHPVYVRQAAAKNIPVVRRPDRKDLLAYLSGETTTSSAIDKTSPLEIPVPVKRPGQNEPDCCTSKKPKFGDSDVQRMKEQLAIRLDTSKETSVTVDNIKSLSDILSPETIATIIVKRIAKKRTTIKENDELQIHSDFQIMVDMDAYNSKDIISHERQYQGRVAILQSKGKIFNNVIAILQSTIAKESKIQDKNKGNKLEFPPPPPPPPPPTTPLLEKPAAYNRYVQEKFFNLNDTEGFKINTMGSYHGSISVNEKSKLTITEPLPAVESKSLVKKKPLNRTPIIIIPNSNCSLVTMYNIREILEQLKFVTNEEQKAAGVQKKNQITIQRAKKDGSMVLYEVVDNIQKLSTADWNRVVSVFVFGPTWQFKGWPFNGGPVEVFSKIKAFHVKYDDEELDLNIARWSVDIIELSRTKRHSDRAAISKYWEILDSYIARNKPFLKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HPC0</accession>
    <name>A0A8J2HPC0_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Similar to ZNF624: Zinc finger protein 624 (Homo sapiens)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">HICCMSTLAB_LOCUS12877</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the snail C2H2-type zinc-finger protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5107705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10249535at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048598">
        <property type="term" value="P:embryonic morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040029">
        <property type="term" value="P:epigenetic regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001397">
        <property type="entry name" value="Datilografo, isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000100">
        <property type="entry name" value="Zinc finger 45-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000690">
        <property type="entry name" value="Zinc finger protein 354C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000624">
        <property type="entry name" value="zinc finger protein 697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050527">
        <property type="entry name" value="Snail/Krueppel_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24388:SF54">
        <property type="entry name" value="PROTEIN ESCARGOT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24388">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="15"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="12"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="945"/>
            <end position="973"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="1054"/>
            <end position="1082"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="1113"/>
            <end position="1140"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="1141"/>
            <end position="1168"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="1169"/>
            <end position="1197"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="1228"/>
            <end position="1251"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="1266"/>
            <end position="1292"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="1293"/>
            <end position="1320"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="1323"/>
            <end position="1350"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="1351"/>
            <end position="1378"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="1379"/>
            <end position="1406"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="1407"/>
            <end position="1434"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="55"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="232"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="264"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="289"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="325"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="554"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1420"/>
            <end position="1439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="268"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="344"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="362"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="554"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="1421"/>
            <end position="1430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00037948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CAG5107705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="1439" mass="162949" checksum="EA8D28E5984EFF24" modified="2022-05-25" version="1">MELGVTTDIGGAVACPVCTLYLREGISLQRHLDTHPKEQVIEALIKASGSSSSLSSLQLPQTQVPQVPQTLQPSPPQQQVNAQSSTSAPTAAAVAAAHIPTQAPFPIGPVFECPPINAMMPPQFASFNYQQFVNNGTMMIPQYAMAPPQANQMMQMLYNPYSMYQQQQVPTVQMISPVSALPTTRIRPVVTVANAETNRNVIISTSTNEHKQIIPEIISEANMERILPDMESCETSTQQSTDIRHDNNCNDNDNNNISVRQLDHRDQQTQSNSPRPVINNSEIVRNDTVSVVCESPASEEDKSESILPDMEEPELDIDADIQCRNEQQQQQQRQHHNQDRHQRFSSTYNSQADNENSNTDTRLNHLTEDQDKLESQESLSSEKLKSSESIELQVNSAPTPIIIDTCQKNEEDHLEHLLITMIESGFVETHEKTNDDDDEPIQESNLKIIKTAQQNEEQMEEESENHLTPEDIKYINNTEACVETEKCIDTSIIDECDFDYAYRYKHSLSAPASPVSASKKISHSYSTRSECGSNENLNFYPAGFDASTLQVDVDDEDEDEEDDDDEEEDEDDDDDDDEEEEEEEESKHVGDNFDEEDMEIEEIASPHTPFAKQNDDDLDNVRSHTPLSAISGISGLRVRRDLSKPSSPVSIRSFGQMEADSHDEETNDSVISQHKNSANCLQVDNNAAVRLNRDESQGAGIETARKSENNSNGIFHQSVITEHVSSFPAIHSQQSITNENYTICSNKITTHQSNLTCGLSQATDPTTSIESKSFQSTITKTVNHIPTTELLNINEDAHSGPMNVFEFDGLQILVPSTFISESSQKAISATSQQSMASSEGGTGIDEEVKSVNMRADETMPPRGELSEQESNGCTEHSAWQLYVGQESSRMSTSYDLMARESWEESEGSDNEAGVPLLDSRSLATHFTSSLFLDRDRKTPTKQRTFKCSQCTEVFDCPKERRVHSTTVHKEAGPSNSCSNSGINEQSETKDIKLLDGPMNPFEDIFVPGLHVQQAYQQQQPLLHQMQPPQQLTDISKVEGDEKSESLALTQGIEISCAMCTQRFSSERSLQMHNRRVHGTEVARRLHDISKCQICNEEFPSVALFNAHLKIHPLECSQCGKYFYRKQNFKLHMKRHLGIKPFPCTICDKAFLTKQKLDEHTNGHTGNAPVKCNLCNETFRRYSNLTQHKNRHHLNIKRKLKDYICHCGEVFHTKKKLAWHKETHDEKPKACTYCNERFIHMASLTRHMRRAHNRRFVPDAQRENENVECPICKCIYLRSSLSVHMRVHNGERPYECQVCSKAFSTKWNLQLHKWTHAARSTKPFKCNQCSAAFYRHSDYTAHMNSHRNVRPYTCNYCGAQFIRKYNCLRHVKEHEENKAYTCDVCNKTFHRSYYLKEHLRVHSGARPYTCHICGKSSSTKSNHNKHVRIHHAREPVNTEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HPR5</accession>
    <name>A0A8J2HPR5_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Olfactory receptor 69</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HICCMSTLAB_LOCUS13227</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5108418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HPR5"/>
    <dbReference type="OrthoDB" id="10335527at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005549">
        <property type="term" value="F:odorant binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004984">
        <property type="term" value="F:olfactory receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004117">
        <property type="entry name" value="7tm6_olfct_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21137">
        <property type="entry name" value="ODORANT RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21137:SF42">
        <property type="entry name" value="ODORANT RECEPTOR 83A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02949">
        <property type="entry name" value="7tm_6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0552">Olfaction</keyword>
    <keyword evidence="7 10" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="8" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="31"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="62"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="189"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="215"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="268"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="314"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAG5108418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="429" mass="49846" checksum="2D098F25EA998C26" modified="2022-05-25" version="1" fragment="single">MDFEDFIDRIFNAITYLKFWKKNFSSLNKDIVNTALNITLLTLAVLICASEAIGIIGTNNLTSFGVCTCQFLYHFSGLCKWVIMILKLDDVKNILIRIKRCHEICLSYIETQKEFFEYNQKIQKLQSNVIMFAKLWFLLCICGTFEWCLNPLIYDCYNIYILKIPTTNYTRSLPYEAFFPWKIDTNKKYIMTFAFQLISAIATSAGMVISDALNVIFLANISFNLEFLNITLVKENKNFAILRFSDSDMAIKKFKSKLRTCLIHHREILEYVFLFFQIKIVIYVIWPQSRDFLTTTMLRYELKVRGGNPTIECVVQLISIVEFWFAVTVDLFLFSFLATRIEERVNGLTTADAIYACNWEQSMINYDGDFTGDHRQTILDINQMISFSLMRAQKPITFQGGLFYVLSLETFKALTGFSLSNAVVLRQLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HQ26</accession>
    <name>A0A8J2HQ26_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS13107</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5108177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HQ26"/>
    <dbReference type="OrthoDB" id="7692173at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5108177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="109" mass="12731" checksum="E4A7C8BDBB085771" modified="2022-05-25" version="1">MNHENDHTNEECEHVLAQLCYLRERYPIKCSNNFEECLLIKNRISMTPLHSPIRKTTRCASLAEQHAMLLEKIPPTHKENKKIINAKALNLKIDNLIVLMNQMKTLKPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HQ39</accession>
    <name>A0A8J2HQ39_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to ogfod3: 2-oxoglutarate and iron-dependent oxygenase domain-containing protein 3 (Xenopus tropicalis)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS10999</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5102406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HQ39"/>
    <dbReference type="OrthoDB" id="427071at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039210">
        <property type="entry name" value="OGFOD3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14650:SF1">
        <property type="entry name" value="2-OXOGLUTARATE AND IRON-DEPENDENT OXYGENASE DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14650">
        <property type="entry name" value="PROLYL HYDROXYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="50"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5102406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="255" mass="28000" checksum="5ADEB2699CFED914" modified="2022-05-25" version="1">MTQEEKKVRQREGKGNKTEAKKDSQDQQQDQDVPVEPKFGPRVSFPYQKVWSRCVLILGVLLIVWYNSKRGKEVSFARQKDILLSRTQNLDCANDYKTELATYPGCVPEKCGRVVTDKLVSNTETEVLYKIALNGMNLGGSDGGASILDLHSGALSKGKKVVKTKIQHAVAHHFGVDADKIYLTKPTFFSRMTNVSAKTISMVGGRVSMFTSGGENLHAVEPVTSGTRFALTVSFTCNPAAAIADPTLKTSKKRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HQ49</accession>
    <name>A0A8J2HQ49_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein hunchback</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">HICCMSTLAB_LOCUS12110</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Gap class segmentation protein that controls development of head structures.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the hunchback C2H2-type zinc-finger protein family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5106126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HQ49"/>
    <dbReference type="OrthoDB" id="1095242at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035282">
        <property type="term" value="P:segmentation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000123">
        <property type="entry name" value="transcriptional repressor CTCF isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001370">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24379:SF121">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24379">
        <property type="entry name" value="KRAB AND ZINC FINGER DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0302">Gap protein</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="13" id="KW-0804">Transcription</keyword>
    <keyword evidence="11" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <keyword evidence="9 15" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="16"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="45"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="73"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="101"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="128"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="163"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="194"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CAG5106126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="225" mass="26324" checksum="8D340D3CE72927B8" modified="2022-05-25" version="1">MKSGEYQRRKKNKTPHKCVKCSASFFHMTKLVEHLKNTHGIENAFSCDECGKAFKSPMNIARHKLIHSGTKKFSCDVCEYTCNQKTNLETHKRRHAKDFLFKCSICKKGFISKADFAEHANVHTNFRFRCDACDKNYFYKRNLIAHLRLCHYEVEKKKNKSSFNCNECELAFTTLGTLRNHIRNRHRVKKRHQYLCDLCGANVSSKKALDIHTRTHTGERDVAYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HQQ8</accession>
    <name>A0A8J2HQQ8_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS12576</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5107081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HQQ8"/>
    <dbReference type="OrthoDB" id="120976at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="195"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="209"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5107081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="378" mass="42798" checksum="05DF16AF499DE668" modified="2022-05-25" version="1" fragment="single">NDVNEEKSSELQQQQQEKEKKKSGGSRELPEIGDSENVASGNSIMCCVLQGAGRVCPSSMRDKHHDGSTPSDRGGCNTSLATNDLPLESLWAAGLDEGMGFPQRCYYANHRTIPITPTTPNKNTEQIWHERNTPYRTPTISTGADSSIIDEIWTSSNDRKYFHASTMSSEMDSNLNIHENNRSLELRDKDSYLNDVENNKDPHKRSYYPSTPTTSGLGSSIEKTQSIETPRSHDPPSHLWYSRADDFSNYNTVKSSHAITRQPRPNPDWFKNDNKFISHRKFGGRPRNDDTEIWSSKIDNTNNMSGYMTQQNRQHRCYHQARKSFSTSMMTDLAAMLSDSQQSLGSTSILVSLSPIYLTINTNYHTHYFCVSDYLSNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HS97</accession>
    <name>A0A8J2HS97_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="18">Similar to Ppm1b: Protein phosphatase 1B (Rattus norvegicus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">HICCMSTLAB_LOCUS12391</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Membrane</location>
            <topology evidence="4">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 16">Belongs to the PP2C family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5106701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HS97"/>
    <dbReference type="OrthoDB" id="10264738at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.40.10:FF:000001">
        <property type="entry name" value="protein phosphatase 1B isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.430">
        <property type="entry name" value="Phosphatase 2C, C-terminal domain suprefamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015655">
        <property type="entry name" value="PP2C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000222">
        <property type="entry name" value="PP2C_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012911">
        <property type="entry name" value="PP2C_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036580">
        <property type="entry name" value="PP2C_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47992">
        <property type="entry name" value="PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00481">
        <property type="entry name" value="PP2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07830">
        <property type="entry name" value="PP2C_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81601">
        <property type="entry name" value="Protein serine/threonine phosphatase 2C, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01032">
        <property type="entry name" value="PPM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10 16" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="15" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14" id="KW-0464">Manganese</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0519">Myristate</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12 16" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="17">
        <location>
            <begin position="23"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00006702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU003465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="CAG5106701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="381" mass="42046" checksum="9FA9649F51FC3529" modified="2022-05-25" version="1">MGAFLDTPNTEKYNEHGSGNDLQYGVASMQGWRMEMEDAHCAITGLEGGLSDWSYFAVFDGHAGALVSAHSAEHLLDSIVETEEFKSEDVIKGIHSGFLRLDHKMRDLLETSKDKSGSTAVCAFISPKHIYIANCGDSRAVLCSAGSPVFSTRDHKPVLPAEKERIQAAGGSVMVERVNGSLAVSRALGDYEYKNVEGRGPCEQLVSPEPEIFVRDRDMEHDEFLVLACDGIWDVMTNQDLCDFIYSRLLLTDDLEAVTNQVIDTCLHKGSRDNMSIVLVTFPAAPKPSIEAQKKEAELEMTIERRIKEIVAQQEGKDGFDYLELLRILVDQELPNLPPGGGLSAKQPLIEQVFREVCPGRAKSIVKTQSFNPLEVNKANL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HSW1</accession>
    <name>A0A8J2HSW1_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Protein sleepless</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HICCMSTLAB_LOCUS12723</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5107386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HSW1"/>
    <dbReference type="OrthoDB" id="6110560at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032222">
        <property type="term" value="P:regulation of synaptic transmission, cholinergic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030431">
        <property type="term" value="P:sleep"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23592">
        <property type="entry name" value="TFP_LU_ECD_Crok"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031424">
        <property type="entry name" value="QVR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050975">
        <property type="entry name" value="Sleep_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33562">
        <property type="entry name" value="ATILLA, ISOFORM B-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33562:SF2">
        <property type="entry name" value="PROTEIN QUIVER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17064">
        <property type="entry name" value="QVR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0732">Signal</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035283878" description="Protein sleepless" evidence="10">
        <location>
            <begin position="23"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="131"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAG5107386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="149" mass="16519" checksum="6A814864FBF94A10" modified="2022-05-25" version="1">MGRSAQLIILSLLVLFIHEGLAIKCWECRSDSDPKCADPFDNSTVPIADCSEKRELSHLKGVKSTMCRKIRQKVNGVWKYIRSCAYLGEPGIGGDERFCLMRTGSYNIFMEYCTCNSKDGCNAGTSINSSWIVSLIAGLLTLGYYLTAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HTW9</accession>
    <name>A0A8J2HTW9_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to Troponin C (Tyrophagus putrescentiae)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS13468</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5108832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HTW9"/>
    <dbReference type="OrthoDB" id="26525at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016460">
        <property type="term" value="C:myosin II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000001">
        <property type="entry name" value="Calmodulin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050230">
        <property type="entry name" value="CALM/Myosin/TropC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048:SF0">
        <property type="entry name" value="CALMODULIN LIKE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048">
        <property type="entry name" value="MYOSIN LIGHT CHAIN 1, 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="2">
        <location>
            <begin position="26"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="2">
        <location>
            <begin position="66"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5108832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="139" mass="15608" checksum="9FD894F3B10A3E36" modified="2022-05-25" version="1">MFDSTKSGKIDKEKVRTILNTLGHTFDDQELELLLKQEDVDGNGVLNFDSFYRVATHFQEDDDDEALQKELKEAFRLYDKEGNGYIPTSSLREILAALDDQITPDQMDGMIGEIDTDGSGTIDFDGKQPLLNGPLLFSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HTZ8</accession>
    <name>A0A8J2HTZ8_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS13482</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5108846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HTZ8"/>
    <dbReference type="OrthoDB" id="268027at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071203">
        <property type="term" value="C:WASH complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019309">
        <property type="entry name" value="WASHC3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10152">
        <property type="entry name" value="CCDC53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5108846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="142" mass="15985" checksum="99B1A3F65CF13396" modified="2022-05-25" version="1" fragment="single">TADKIPVEAAPTTPEAKYPDKDPVGQDEADTKQDVESTKVEVQNQEVSDNLEPISMHPIYRKYFKMVNFGVPKPASVHQNLVVYGHNDVYPGQHVFPYFFCIELLCVACGPCTFCKKCAFVLERSPKDINIQISYQTLSTEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HUM5</accession>
    <name>A0A8J2HUM5_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similar to l(2)gd1: Coiled-coil and C2 domain-containing protein 1-like (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS14031</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001383">
        <property type="protein sequence ID" value="CAG5109395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HUM5"/>
    <dbReference type="OrthoDB" id="19996at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001227">
        <property type="term" value="F:DNA-binding transcription repressor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08690">
        <property type="entry name" value="C2_Freud-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037772">
        <property type="entry name" value="C2_Freud"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039725">
        <property type="entry name" value="CC2D1A/B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13076">
        <property type="entry name" value="COILED-COIL AND C2 DOMAIN-CONTAINING PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13076:SF9">
        <property type="entry name" value="COILED-COIL AND C2 DOMAIN-CONTAINING PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2" evidence="1">
        <location>
            <begin position="1"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5109395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="158" mass="17993" checksum="FACEA2068F9F8D84" modified="2022-05-25" version="1" fragment="single">SCTDLTDSDVELSIIRGVNYPKEVDSYVIYEFPYPTENSPTDRTSTVRNTSAPEYDATFTLTGSIDRSSRQCQRTYKRHSLKCQVWSKGGFLRSDNLLGTVTVKLQPLETQCILHDTFPLMNGRKAAGGQLEIKIRVRNPITTKQIEKMTDRWLVIDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MBA8</accession>
    <name>A0A8J2MBA8_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Vacuolar protein sorting-associated protein 53 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HICCMSTLAB_LOCUS3256</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endosome membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
            <location evidence="1">trans-Golgi network membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the VPS53 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5081341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MBA8"/>
    <dbReference type="OrthoDB" id="10261632at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000938">
        <property type="term" value="C:GARP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.110">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 53, C-terminus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039766">
        <property type="entry name" value="Vps53"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031745">
        <property type="entry name" value="Vps53_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038260">
        <property type="entry name" value="Vps53_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007234">
        <property type="entry name" value="Vps53_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12820:SF0">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 53 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12820">
        <property type="entry name" value="VACUOLAR SORTING PROTEIN 53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16854">
        <property type="entry name" value="VPS53_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04100">
        <property type="entry name" value="Vps53_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0967">Endosome</keyword>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Vps53 N-terminal" evidence="10">
        <location>
            <begin position="36"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="domain" description="Vps53 C-terminal" evidence="11">
        <location>
            <begin position="691"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="354"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="93"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="354"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF04100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF16854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAG5081341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="823" mass="93533" checksum="FFC91377A672BE73" modified="2022-05-25" version="1">METHEEDDIDELMSNFFTFPPDVQAVLPSNDPLDQPDFNVVDYINQLFPNEQSLSNIDDVINEFEYKKRSIDKEIRSVVRGQTNGDQDGRAALEEAQKTIKQLFVQIKEIKAKAEQSEETVKEITRDIKQLDFAKRNLTASITALNKLHVLVGEVDSLRILTEKKQYGEIVLKLQAIMEVMQFFSKYMDIPQIKELSDEVNQIEIELAQQITTDFKEAFSGQNLKHFTQLTEGCQVLSVLDPKVKKDLLIWFVNVQLQNQDIAWLDKIDKRYTWIKKHLMDFEQKFGSIFPLDWEVSERIAVQFCHNTREDLSKLMQKRRVEIDVKLLLYAIQRTSNFESLLAKRFTGITLKTSSPSLTSTPSTSPPNPTEESTNPFEESLEKEEPKPSPSPFANLIGKCFEPYLNIYIESLDRNLAELMEKFVLDCKNQPPGSKDFDGVEGPSSVLSSCADLFVFYKKCMLQCTQLSTGSIMLNLSETFQKYLREYALKLLQNNLPKIGGGSLSLGSSMSSITRDFRDLSTAGLIQNFQSFLKEGETTRFSKEEQSRICCILTTAEYCLETTQQLEEKLKEKTDKNYAEKINLSQEQDLFHNVISNCIQLLVQDLEAACDPALTAMIKVPWGSIESVGDQSAYASTIIAHLKQTIPTIRDRLSSCRKYFTQLCVKFVSSFIPKLVQQLYKCKPLSAVGAEQLLLDVHMLKTALLDLPSTGCQVARKAPATYTKVVVKGMAKAEMILKIVMSTTECPKSFAEQCRRLLPELQLPEFQKVLEMKGLRKQEQLGLVEMFKATAADNLEGGGLVVESPEHEAGKIKRLEKLIKKRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MCK9</accession>
    <name>A0A8J2MCK9_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to Ell: RNA polymerase II elongation factor Ell (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS3911</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5083719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MCK9"/>
    <dbReference type="OrthoDB" id="6284217at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008023">
        <property type="term" value="C:transcription elongation factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000987">
        <property type="term" value="F:cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032968">
        <property type="term" value="P:positive regulation of transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042795">
        <property type="term" value="P:snRNA transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2670">
        <property type="entry name" value="E3 ubiquitin-protein ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042065">
        <property type="entry name" value="E3_ELL-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031176">
        <property type="entry name" value="ELL/occludin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019464">
        <property type="entry name" value="ELL_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23288">
        <property type="entry name" value="OCCLUDIN AND RNA POLYMERASE II ELONGATION FACTOR ELL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23288:SF17">
        <property type="entry name" value="RNA POLYMERASE II ELONGATION FACTOR ELL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10390">
        <property type="entry name" value="ELL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNA polymerase II elongation factor ELL N-terminal" evidence="2">
        <location>
            <begin position="2"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="95"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="137"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5083719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="310" mass="34379" checksum="EC6657F86C613E71" modified="2022-05-25" version="1" fragment="single">RLSFPSPQANHGSVNFTFSLSDGHDVEGPQGAFECIQQTNPHNLESLGTLPYKMRIHANEDVYEKTRHRMAVCAENNQNKCTRVLLKANGPDIGRKVKVKSAGKTAAAPSNARHTNNHRDTSIPNSTSRPTIKNSIANSQSSSALSSQPSAASSSFLSSNSSSNNSMMPSLSSSSATAAALTARFLKSTSTPSARSQPDKKVSDLLKRPLRERLIHILALRPYKKPELYERLNKEGLKDREKKEMVNLLRILSTVRNNSYHLHRHVWNDVQEDWPFYSEQDRAMLKRRKPQNLTPPGSSDGGSSGNFIIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MD77</accession>
    <name>A0A8J2MD77_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Bestrophin homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HICCMSTLAB_LOCUS3608</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Forms chloride channels.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the anion channel-forming bestrophin (TC 1.A.46) family. Calcium-sensitive chloride channel subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5082612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MD77"/>
    <dbReference type="OrthoDB" id="201595at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034707">
        <property type="term" value="C:chloride channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005254">
        <property type="term" value="F:chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000615">
        <property type="entry name" value="Bestrophin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021134">
        <property type="entry name" value="Bestrophin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10736">
        <property type="entry name" value="BESTROPHIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10736:SF11">
        <property type="entry name" value="BESTROPHIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01062">
        <property type="entry name" value="Bestrophin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0868">Chloride</keyword>
    <keyword evidence="6" id="KW-0869">Chloride channel</keyword>
    <keyword evidence="6" id="KW-0407">Ion channel</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="476"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="593"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="667"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="476"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="511"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="527"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="550"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="675"/>
            <end position="697"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00034769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG5082612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="704" mass="78489" checksum="DD64D87AE5C61614" modified="2022-05-25" version="1">MMESEKKIFEMMNKKAAMSKYWMPLVWATNIINRARKEALITSDHVVQTLLVELSDIRKRLGALIGYDTVCVPLVYTQVVTLSLYAYFFSALLGRQFVVHSVGAGKYEEPDMYFPVFTTLQFCFYVGWLKVAEVLINPFGEDDDDIELNWLIDRHIKVDIVSKKLLLNHANKNYMIVDEMHEEHPELLKDQYWDEVVPKDLPYTVASEQYRREEPKGSAEHYKIKESDALYANVMLGSQMHSVNQHRKVHQDDVYADYESVDTPLVERRKNWLQRQINRMGSVRSSSTTYSSNGGFFTRNRHNSVYSSPENGVLPQIHSNSNNKPSFYDRMVGRKSMRSQRMSRQGTMTKLNSVPVSLKNRPRIPTPDVTKEVVDREQRLALSANNTANIGAGVVGVIPANGTYSSDVPTVVHVVLSPIAETENNQASGKGGTATLAQAVLSPTLTSAGIVTPVTLTPVTMSQLTQLGIVTTASSPMPRINNVQTPSNNSLEERTTLTEVNSIEEEERSTEGSSINSQSTATTVEQQNDEDSELDEDENDRSTPMIGERQSPTGGSHGSTPTFDSYNERSAILMSPDKLGGYIVNPVSEIQQKQSNLDARGRRSTSLPCPPASMLRDDRSNSLPHSPAIPAVNKHVNPVIGGLNSLNLDGRQRTGSIGRELTRSRIHEPHRRISTPASTNSNILAANSNVTRQNLPDNNRDEIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MDT8</accession>
    <name>A0A8J2MDT8_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Similar to NUP205: Nuclear pore complex protein Nup205 (Homo sapiens)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HICCMSTLAB_LOCUS3972</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NUP186/NUP192/NUP205 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5083938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2019644at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044611">
        <property type="term" value="C:nuclear pore inner ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006999">
        <property type="term" value="P:nuclear pore organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021827">
        <property type="entry name" value="Nup186/Nup192/Nup205"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31344">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP205"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31344:SF0">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP205"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11894">
        <property type="entry name" value="Nup192"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAG5083938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="1911" mass="216239" checksum="9E519AD979271C0D" modified="2022-05-25" version="1">MTEKTGINDAWTSFKELQNFIERYVVSASTTHDPQYHEFMETLRNHRQNFLSLMKNQPKDAKSREEIQKGITESVTLPGLGNHVLSKELVDETIIISDMYDLNEFIALDLLCTAQLQMSNHPGLTRGLTAILLYYDGRKALTSALRTLVHARIGHSWVLDTPVALTKKITEYTNKMQEDGLLDRVLSLLEQMDPIKEQDLLQQNRALGGPKHHQMVMRLYNDTRQDLADILYLWSAQTSLPTQITFKLLSFLRRRQPETDARNGGPDKVTLALIMALLSAINLSSLNNREDGEVIVKSVPLVAERGVLEELFQELMNPNVAWENSGLCGLIQLALAVAVTTIKSASNLSIGQNINQEDEILVEAALSNKAFHCLTNVIFKNEDIHCEEFYVRYFHTLISDFITLMPMKVKELRSKADEFMRFITAYQQEGVEPPVNPDDHFEYLMLAVSELYKKDPLELNLVLEYWCQNDNVTHLSSNVHVTRLPARQVALFKFVRLAGEILPAGLFVPYLKMIASLASSPQAARHAFNFLKPNGSSGSTISWDHFFNSLNRYYYNLRQELPPSQDTIYRQHCHPKGITPHEVKGLEAVLNVVQVVAKYDEMSRIAICEHPGWKVIPALIGLVGCAMPIPLKGVLVRTLAALAKSPESSSTIWQSLEVAQILCTIPTTSSYQPRGVQTELEEIESRNEEYPLTRAMLELLDALVDYPIPRLLGVGQRNPGFDPYLYFIINTVFLRFNTRSYKNPKEKWLVADACLKIFNKLIAQYEPNVEDFVGCRVELQGGDSTLVNPEPGYHIMTQLHSNSEFLHVILYILDEGRHNLETYDYFPGKESLENSTFNCLRILERGLRIQHQYMTQLAVATSNKIVTGLSKLLLGVNPRTGKPDHMINIAMYVAFNSWLPKHAYTAIGIIQGVANEPGADSELLSTFTSTSQMTLTIRHGFVECLDMDPVDPGSQELEENSGNCKDRILLLLMQSIVRPAPNLAHYLLGFDITKDIKKTVIQQPGILGFPRTCLHSILGILEQTLERGRDKITEACYWFLHTLASNSKTSVPVLRFLRTSTNQDFVQRHLSKLPFQGKNRATELACMSWLLKLAAIELHVTGGNLQNSLVQRLVGNPMQDREQILPPSQKLLMDLLHYIDFELQIEPTKSWEFFDPSQVEMVLGKCSVPVVQNGGPQLIDIRRLHLLIKEELSVTQNSATATQRKLMQQELQSILAYALKRNQTKTLSYATVKFVEGWCQATEILFSVATSQHLPTSQKQNMLLNLTHDLLQKMTSCEALNEIKTLVSGTVLILLVNLKNTFAVNNEESSEILLSSSPSYATTMKIILSHILQWILNSGASSQKVRTHLYGALLNFLCVVGLEKSEFSNESSDTTYVSQLDSSLYRSLTIHERSHRYATIQVINGFGDKLMDIICHNCSGGHDVCKMLALSCLDKILELDCENSWIVYLASRGYMKHMIDSLLESDNLLRSMLQPDPVTLRPLYLYEAKMATFCRMASSRLGAESLLENKILSCLSSISVFDQHPDVQISFETSDSFLPPIGQRYQQILLPALYLCDALLTTLGTENQSCAIQVCGFIQSHRDTVEMILRTAALNTNNSFLNQVACLTGVIARSANIDMYQLVERELINIENKDSNTESNNGMRELRAHLFRLQKLMVSLLPKFNNQALIYPHDQESVVQQQYSSVKIVANVLLYARNQMQHTRMDQKIRNLLFEPYLTKTHKDSKRNNDSCGVGLGSILDQLVSATTLLHSELPHLRSLLMTISVVKNMGSTDLKKYLIPEEMELDMTKQKIVVSKRLEKAVDEKRKNIKYCSIIVEHSLYILWSHLDFYTTSSSSKYNKSQFVGLDDNNLAVSADMLADLKQGLVSVLNDSFITQIVDLSQHEYSMVEQTFVEALIRRIKRLLQFITIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MGC9</accession>
    <name>A0A8J2MGC9_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Similar to Nep2: Neprilysin-2 (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HICCMSTLAB_LOCUS3077</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase M13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5080683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MGC9"/>
    <dbReference type="OrthoDB" id="6475849at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000718">
        <property type="entry name" value="Peptidase_M13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018497">
        <property type="entry name" value="Peptidase_M13_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008753">
        <property type="entry name" value="Peptidase_M13_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733:SF167">
        <property type="entry name" value="FI17812P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733">
        <property type="entry name" value="ZINC METALLOPROTEASE FAMILY M13 NEPRILYSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01431">
        <property type="entry name" value="Peptidase_M13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05649">
        <property type="entry name" value="Peptidase_M13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51885">
        <property type="entry name" value="NEPRILYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M13 N-terminal" evidence="10">
        <location>
            <begin position="3"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M13 C-terminal" evidence="9">
        <location>
            <begin position="215"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF05649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAG5080683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="352" mass="41172" checksum="687F2B5D95C91838" modified="2022-05-25" version="1">MTEEWPTVNWLKLFNGSTITHTYFTNQSIVTIKNLDYLRNLLQLLKETPKRKTVEYWAPFVPSINLSKLELTYKKINDPSYIHQGHNCFNNIQTQLPDLVYAIYLRNNPMDQKIRSRVHQIALDLKNTLLDIFNKTEWLDTKTRDQLIKGINSFRIIVGYPDELMDDQKLIEYYRELIITQDNFIGNLLISIANFGVDKLWNDAIERRPKNLAAYSLDHHTLSPLVMEKIIFNPNRPHYVNYAIIGFLLSHEISHAIYNIHRMFTNNRTIENGWSFTSNQKFNTTKTCLIDQYGSFLIEGTNQTLNGTLLFLENSADNIGIPLAYLAYQNWKKNHAAEITFPTLPYNSNQLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MGY6</accession>
    <name>A0A8J2MGY6_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to cyb5d2: Neuferricin (Danio rerio)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS5835</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome b5 family. MAPR subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5090996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MGY6"/>
    <dbReference type="OrthoDB" id="10257697at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050577">
        <property type="entry name" value="MAPR/NEUFC/NENF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10281">
        <property type="entry name" value="MEMBRANE-ASSOCIATED PROGESTERONE RECEPTOR COMPONENT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10281:SF4">
        <property type="entry name" value="NEUFERRICIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="2">
        <location>
            <begin position="52"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5090996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="264" mass="30315" checksum="10479AC7D1D9C811" modified="2022-05-25" version="1">MAHKVKMWIPVILAIGWSLYLNEWTRSITGKLMYGDYIGAYKLYMGDTDKLFSKSELEKFNSPESGLYLSILGQVFDVSKGEQYYGKGNTYHAFIGRDASLAFITGDFSDKGLTDDLSSLTNKQAKALDNWLKSYHEKYLFKGKLVGRFYDQYAAETPEYHKFLAKVLKAEAEESEKDKVNKIFPPCNVEWNPEEGTKFWCTNQSGGIPREWIGVPRQYYENPSSPQNRCTCVDLKGQDYLNNKSNFQEYKDCAKDAPVCYVKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MHN0</accession>
    <name>A0A8J2MHN0_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Venom protein 100-6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HICCMSTLAB_LOCUS3943</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase M13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5083836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MHN0"/>
    <dbReference type="OrthoDB" id="7683024at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08662">
        <property type="entry name" value="M13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1380.10">
        <property type="entry name" value="Neutral endopeptidase , domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000718">
        <property type="entry name" value="Peptidase_M13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018497">
        <property type="entry name" value="Peptidase_M13_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042089">
        <property type="entry name" value="Peptidase_M13_dom_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008753">
        <property type="entry name" value="Peptidase_M13_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733:SF224">
        <property type="entry name" value="NEPRILYSIN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733">
        <property type="entry name" value="ZINC METALLOPROTEASE FAMILY M13 NEPRILYSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01431">
        <property type="entry name" value="Peptidase_M13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05649">
        <property type="entry name" value="Peptidase_M13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00786">
        <property type="entry name" value="NEPRILYSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51885">
        <property type="entry name" value="NEPRILYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035248898" evidence="9">
        <location>
            <begin position="27"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M13 N-terminal" evidence="11">
        <location>
            <begin position="61"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M13 C-terminal" evidence="10">
        <location>
            <begin position="499"/>
            <end position="698"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF05649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAG5083836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="701" mass="82095" checksum="5A5C2E009EB6E2D2" modified="2022-05-25" version="1">MVTFSLKNMGLPLLAVIFFTVAAVESSNNKKKDSIRNQNSLIKNMEYGLYMLQNMNASVDPCDNFYEFACGDADDKSNKYYDKADNDMDRRIEILITDSHRSFKFEPFKFISDYYYSCKNLKKNHDDTELLNELISKLGGWPVLEGDKWDDTDFNWEKYVEKAISIGIVVDDFYNLNTDLDEGVVKFELDPPVSRDSESDLSNNKLSNAYFKFMSDVAIFLGADIDQTKELKLSLEFGHDINTLYYSKVYNEDDYNPVEMSVKEMIEKWPSIDWIRSLSSNTKPYYNFTNETNVHIEFPNFITHFEKLLNRTPKRVQANYLVWNFIELAIRFINSKTLWDYSQTYKKIRYSYTTKIDQIDCKELVKTDLNPLLQAYYIREYPVEERTKSEFHAIYSNVKNKFIEIVNSSKWLDSNTKIEIIDKVASIQTVIGYPDELLNDDQLKNYFEGLEITRDNFYKNYLNAKLFEKKIINFQTFNKVSSVKTGVDLFTFMYEEPNNAMYDIFDNFMSVSIELLRNYFFDVERFNYLNYGVIGGIIGHELSHAVDSENRLLKKTGLRYKWSHLSNDEYQKKETCMINQYKINYPTENEIELKAAKYLSENIADNIGTKIAYLAYQDWIAINGHEPNLPGLSYTPNQLFWISFANQWCQPKSVLSNWDDDDHASDDKRVIGTVSNSIEFSKDFNCPVGSNMNPSNKCIFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MIV6</accession>
    <name>A0A8J2MIV6_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS3959</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5083884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MIV6"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5083884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="105" mass="11603" checksum="84DBC6DFFF4D46AA" modified="2022-05-25" version="1">MLGQRFNATEIKLKNSTLETILSLGKNDSPIGSGPCYQSIGPGSNPAYTNEYFQYLSVLFCSAQEIQTSSNLKSLPPTVIVAHDLKLLCTESEVLKFLKKFIKMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MJ59</accession>
    <name>A0A8J2MJ59_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS4251</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5085005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MJ59"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="193"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="138"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5085005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="381" mass="43338" checksum="FA43685C5A6DA502" modified="2022-05-25" version="1">MADCTMPHYHIIYPNVWLEGGHTLDEVGRLIMKQVTENSLAGLSSEDTIFTINKIPALLMIDNVKFYWYFQIPGDPVLPDQVKYLICPALFRRLSLAISCYNAHDDDDDEEKDDEEDNEEEDDKEEDDEENNETIIVSSSSSQMSDSGLSDISFDDDDTLMEACLMLEDLDQSLTIDEADFEDDDISYQLEQTAASDQESSTFIQSQSSNFSDSQGQSTFNQSQSFNYSSIQDSSTFIQPQSFNYSSIQGQSTFNQPQSFNYTNIQDSSTFIQPQSFNYSSIQGQSTFNQSQSFNYTNIQDSSTFIQPQSFNYSSIQGQSTFNQPQSFNYTNIQDSSTFIQPQSFNYSSIQDSSTFIQPQSFNYSTIQDSSTFIQPQSFNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MJE6</accession>
    <name>A0A8J2MJE6_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Similar to Alyref2: Aly/REF export factor 2 (Mus musculus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HICCMSTLAB_LOCUS4478</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5087300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MJE6"/>
    <dbReference type="OrthoDB" id="1049195at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051229">
        <property type="entry name" value="ALYREF_mRNA_export"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025715">
        <property type="entry name" value="FoP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19965">
        <property type="entry name" value="RNA AND EXPORT FACTOR BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19965:SF82">
        <property type="entry name" value="THO COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13865">
        <property type="entry name" value="FoP_duplication"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01218">
        <property type="entry name" value="FoP_duplication"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Chromatin target of PRMT1 protein C-terminal" evidence="3">
        <location>
            <begin position="154"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="15"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="152"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="19"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="152"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="183"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG5087300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="224" mass="23688" checksum="659A5F6FDC699938" modified="2022-05-25" version="1">MKMVDKIEMSLDDIIKQNKGGRSRGAARRGRGSAGSLRRIPRGSPRAGGGVMRGRNRGGISRAAASYTRGDVNSAWKHDMFEGVKKVGRGSIGSTGTTKLLVSNLDFGVSDSDIQRRADAIKAMKQYNGVPLDGREMNIQVATSELPVTTSIRGSSRLAGNTFSQRPTTNRFRGARGASAPRGRGGPGGRRGGSGRGGSARTPAKTPTAEELDAELEAYVKEVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MM76</accession>
    <name>A0A8J2MM76_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Cell cycle checkpoint control protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HICCMSTLAB_LOCUS8633</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the 9-1-1 cell-cycle checkpoint response complex that plays a major role in DNA repair. The 9-1-1 complex is recruited to DNA lesion upon damage by the RAD17-replication factor C (RFC) clamp loader complex. Acts then as a sliding clamp platform on DNA for several proteins involved in long-patch base excision repair (LP-BER). The 9-1-1 complex stimulates DNA polymerase beta (POLB) activity by increasing its affinity for the 3'-OH end of the primer-template and stabilizes POLB to those sites where LP-BER proceeds; endonuclease FEN1 cleavage activity on substrates with double, nick, or gap flaps of distinct sequences and lengths; and DNA ligase I (LIG1) on long-patch base excision repair substrates. The 9-1-1 complex is necessary for the recruitment of RHNO1 to sites of double-stranded breaks (DSB) occurring during the S phase. RAD9A possesses 3'-&gt;5' double stranded DNA exonuclease activity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the rad9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5097289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MM76"/>
    <dbReference type="OrthoDB" id="60092at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030896">
        <property type="term" value="C:checkpoint clamp complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071479">
        <property type="term" value="P:cellular response to ionizing radiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000076">
        <property type="term" value="P:DNA replication checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031573">
        <property type="term" value="P:mitotic intra-S DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.70.10.10:FF:000005">
        <property type="entry name" value="Cell cycle checkpoint control protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.70.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046938">
        <property type="entry name" value="DNA_clamp_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026584">
        <property type="entry name" value="Rad9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007268">
        <property type="entry name" value="Rad9/Ddc1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15237:SF0">
        <property type="entry name" value="CELL CYCLE CHECKPOINT CONTROL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15237">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04139">
        <property type="entry name" value="Rad9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF009303">
        <property type="entry name" value="Cell_cycle_RAD9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55979">
        <property type="entry name" value="DNA clamp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="281"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="446"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="281"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="318"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="374"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00059283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR009303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAG5097289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="466" mass="51236" checksum="977010C7889959E3" modified="2022-05-25" version="1">MKCVIPGTNVKILARAIHALGKIGEELYVLPQERSLSFRTVSMTNSAYCDFTFNDQYFSYYNFGNLEEDDASKCKVSMRAAMSAFKTPNLMDKLVETCHIKLQANATKLIIVLNYKNSVRKTFLLAILNCENLQASYNKDNVPNHLIVQPKILSDAVQNFQQNLTEITLDVSSDKILLRNYVNDTSNLSNLTRTQLALAVGEFDTYTIGQDACVTFCMKEVRPIMSIAELVERPLHLLFEVAGRPVVFILKDISFEANLVLSTINPDLGNSGLSDASIHNRRQAVKKRGALQRGTKSSKTKEKPAKKSKVSSVAGSSMIQSVNTDNSPMTKGKKVPTIAEKAVKSPRTSNDSDRTVPVSDGSGRRRSSLIAETLSEQSTPSGRTLSGASSASIFTPAGKRRTSGNDGNYFDDQPMEQDDIVPSSPPPRSSKKARMIFKKCLQATFDPTSLPGHDLVLAKDSDEESD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MMJ1</accession>
    <name>A0A8J2MMJ1_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similar to RTase: Probable RNA-directed DNA polymerase from transposon BS (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS4099</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5084418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MMJ1"/>
    <dbReference type="OrthoDB" id="7989680at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33273">
        <property type="entry name" value="DOMAIN-CONTAINING PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33273:SF2">
        <property type="entry name" value="ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14529">
        <property type="entry name" value="Exo_endo_phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="1">
        <location>
            <begin position="85"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5084418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="582" mass="67301" checksum="FD3CB630F56F97A8" modified="2022-05-25" version="1">MFLENNTIDIAMISETKLTSKNFFSFRNYQIIRTDRPNVKNGGGTAIIIHNRIPFSAITYPNSLHNKSLEFSVAKITTQSNNTLILISIYARHSNKLSFINELYKIFTDFKLTNANTYHIIAGDFNARHPEWGSNIINARGRQMFQWYEEMSLQYRTVLYPAAEPTFPSAGSFLDYCLADARIELLNIIQGKIKILPYDSDHSALFFEIDTSSLFDGINFSTPSNPTFNYKKANWRKFQKYLMDNYNLDIPFNRNLTIDEIDSYIINLEETIADAIDKIILKNDPLSNPGQWKYINNRIKILHSYKNRLITILHNTIKLQNFRNTQVIKNIKKQITEINNQLYKEFQKTTTAYWEAKSRSVNFRDPKTFFPTINKFFRRKEAPTISNILINKNNPILIDELKQSEELTELNDDQYIITKETSKLNIIGKQFEIINSPRYTNLLTDIKNTADNCADEIKNSIQANRQNNSTITNFSNENRAFYPSIDQDAPKIFHSFITTSILLKKAKNKTSSGTDNIPMIVLKNLPEQFIKDYTAVVLIIWEYLSEGNKPIQKINRVRLNPEPPGLSLGVAKAGWVPLIDLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MMT8</accession>
    <name>A0A8J2MMT8_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ras-related protein Rab-21</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HICCMSTLAB_LOCUS4145</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Endomembrane system</location>
            <topology evidence="10">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5084580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MMT8"/>
    <dbReference type="OrthoDB" id="63533at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032482">
        <property type="term" value="P:Rab protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04123">
        <property type="entry name" value="Rab21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000550">
        <property type="entry name" value="ras-related protein Rab-21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041833">
        <property type="entry name" value="Rab21"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47978">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0636">Prenylation</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00037868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAG5084580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="220" mass="24690" checksum="E0D9A39066E86909" modified="2022-05-25" version="1">MASSILNSGSGYNFKVVLLGEGCVGKTSVALRYVEDKFNDKHLTTASFLNKKLNINSKRVNLAIWDTAGQEKFHALGPIYYRMSNGAILVYDITDEDTFQKVKSWVKELKKMLGDDVCLAIAGNKVDLEKDRNVPIEEAEEYAKQVGAVHFHTSAKQNRNIEEMFLDLTKRMMAHADEIEQKKSSLSRVNSNRRNVVVVEDDVEQTQSTRSSCCGGSTHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MMY8</accession>
    <name>A0A8J2MMY8_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS8441</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5096899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MMY8"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="17"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5096899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="111" mass="12477" checksum="775CF57628790D40" modified="2022-05-25" version="1">MSLIALDHQKEEINRKITIGSVTTLGIISLIIGGIAIQKTIRQFLSKPRKPSRVDEKPVIIQLQTVEEKTSTSQEVKEPHPTTVTIEEAPETVEKSTKPKTFRLKDYKSPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MNI5</accession>
    <name>A0A8J2MNI5_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to Fbxo6: F-box only protein 6 (Rattus norvegicus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS7196</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5093870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MNI5"/>
    <dbReference type="OrthoDB" id="1107553at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006516">
        <property type="term" value="P:glycoprotein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031146">
        <property type="term" value="P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.260:FF:000012">
        <property type="entry name" value="F-box only protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007397">
        <property type="entry name" value="F-box-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039752">
        <property type="entry name" value="F-box_only"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12125:SF5">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12125">
        <property type="entry name" value="F-BOX ONLY PROTEIN 6-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00646">
        <property type="entry name" value="F-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04300">
        <property type="entry name" value="FBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01198">
        <property type="entry name" value="FBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51114">
        <property type="entry name" value="FBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="30"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="FBA" evidence="2">
        <location>
            <begin position="100"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5093870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="305" mass="35501" checksum="0BD95167C0B4F14B" modified="2022-05-25" version="1">MTKYFRFISKILGLRQQRVPFEEDENNGLMLADKYIPEELIGELLCYVDHKSLLNCQLVCRRWKDLIREYVFRKKAEMTFGQSLQCLSNCEDPWKIYYKICKKNPFERNLLKNHSGQDGLKKHWVITRQGGDHWKIESPPVGVPPLPKDPVFEGSNSCFVTSYSQCSKRQLIDLLDEGLSDVLLDTFQPTIEVGEWYSCRWDCPAKYDCIVSLLDKNDKELDVYVFRDNLEDDNDKQNKWLHFTHEFKNYGPGVRKILFQHSGKDNLFWAGHYGSKMAGASVIVKVEPKTASGSPRKRKSSIELD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MNL4</accession>
    <name>A0A8J2MNL4_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS4236</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5084942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MNL4"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5084942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="107" mass="12303" checksum="B98A5C82902E28EE" modified="2022-05-25" version="1">MIKSIPLGLTSHTLKTSMKKKFLDGEEDPEKVYVVEWHDGPEPLGGRICYNARVIAILKKITVLEKKFKALDGMQSPRRVDPKLFDKDVSLKAKEPQKPEKKKRSLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MNT1</accession>
    <name>A0A8J2MNT1_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">dual-specificity kinase</fullName>
            <ecNumber evidence="3">2.7.12.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">HICCMSTLAB_LOCUS8744</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MNB/DYRK subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.12.1" evidence="3"/>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5097521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MNT1"/>
    <dbReference type="OrthoDB" id="9332038at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004712">
        <property type="term" value="F:protein serine/threonine/tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd14226">
        <property type="entry name" value="PKc_DYRK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000087">
        <property type="entry name" value="Dual specificity tyrosine-phosphorylation-regulated kinase 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000117">
        <property type="entry name" value="dual specificity tyrosine-phosphorylation-regulated kinase 1A isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044131">
        <property type="entry name" value="PKc_DYR1A/1B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050494">
        <property type="entry name" value="Ser_Thr_dual-spec_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24058">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24058:SF28">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE MINIBRAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 16" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="15">
        <location>
            <begin position="38"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="414"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="438"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="67"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00051680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CAG5097521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="544" mass="60910" checksum="D857E99FDB60AED1" modified="2022-05-25" version="1">MQGEDGSHKKERKLYNDGWDDDNHDYIIKNGEKFLDRYEIDSLIGKGSFGQVVKAFDHEEQTQVAIKIIKNKKPFLNQAQIEVRLLEMMNRADTDNKYYIVKLKRHFMWRNHLCLVFELLSYNLYDLLRNTNFRGVSLNLTRKFAQQLCTALLFLSTPELNIIHCDLKPENILLCNPKRSAIKIVDFGSSCQLGQRIYQYIQSRFYRSPEVLLGIPYDLAIDMWSLGCILVEMHTGEPLFSGANEVDQMNKIVEVLGMPPKHILDQAHKARKYFDKVPTDGSYVLKKSKDGKKYKLPGTRRLHDILGVENGGPGGRRLGEPGHSISDYLKFKDLILRMLDFDPKTRVTPYYALQHNFFKRTADEGTNTNIAAANSANTSPAVVSMSQDSGLVTMSGQGSGSTSSLMQVLGMPGGYQSMECESSPRHSSSRRVMTTGYPSSASASIDAPASGPASIQSMDNNSRIQSSLGTYNSLILPGMAHLPNIMTSPMIPQQNFYNYGYTGADTHGIIRQPASVTTGKQRDPEREDSPMVGVCVQQSPVAIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MPB1</accession>
    <name>A0A8J2MPB1_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Gustatory receptor 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HICCMSTLAB_LOCUS7742</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the insect chemoreceptor superfamily. Gustatory receptor (GR) family. Gr5a subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5095505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MPB1"/>
    <dbReference type="OrthoDB" id="5800391at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008527">
        <property type="term" value="F:taste receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050916">
        <property type="term" value="P:sensory perception of sweet taste"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009318">
        <property type="entry name" value="Gustatory_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21421">
        <property type="entry name" value="GUSTATORY RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21421:SF29">
        <property type="entry name" value="GUSTATORY RECEPTOR 5A FOR TREHALOSE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06151">
        <property type="entry name" value="Trehalose_recp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038981">
        <property type="entry name" value="GRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0675">Receptor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="77"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="117"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="150"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="256"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="345"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="377"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="448"/>
            <end position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAG5095505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="472" mass="53643" checksum="04B963D0B89FA9C6" modified="2022-05-25" version="1">MLSPKGSYNNTKRSVDYKSACHKVWPFLVTEGNNMSNSRDDRALHHYTVNRSVPVKNFLAPEVSGKRNTPDENNESFHRAIGSILVVAQLFGVLPLYGIRAPSSQKLSFKLNSLKTFYSISLMIALIFMAVISIIHMIRTLNSDAFQIHGGIAAATAGAVFYGNSLFGLGLFMWLSPRWISLQQQWRSMELQLDRCKQSRPRLRWKFRAIAITIMTLALTEHVLSILVNLPDNKESESSNNTWKDSLRIYSQKSHAFILSSLNYNVALGIFLFTFSKIATFTWNFTDVFVMLVSTGLAERYKSLNKYLLKTSSIKNSNIDWGEFRENYATLSSLVKRTDSDMSPVILLSFVNNLYFICLQLLNGLSTEDMSMLNTVYFFFSFAFLLSRTIAVTLFTARINDQSKVALPILYNSTAVNYTVEMQRLQFQLTTDEVALTGLKFFYITRNFMLAVAGAIVTYEVVLLQFNVAMKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MR47</accession>
    <name>A0A8J2MR47_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS8330</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5096678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MR47"/>
    <dbReference type="OrthoDB" id="7700372at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2590">
        <property type="entry name" value="BEN domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5096678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="98" mass="10674" checksum="FADE849009B23B89" modified="2022-05-25" version="1">MLRNQNQPPAQQPNAPVDQVEIGHPGSNVFVTQQQWDAADFQNSYTSMGISLVRALFNDDVLMASNLRGGPSKIHKNAPRRPGLNSVIPGLNSEATHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MSU8</accession>
    <name>A0A8J2MSU8_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to lgr4: Leucine-rich repeat-containing G-protein coupled receptor 4 (Danio rerio)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS12132</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5106181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MSU8"/>
    <dbReference type="OrthoDB" id="2013775at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050216">
        <property type="entry name" value="LRR_domain-containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051:SF1">
        <property type="entry name" value="RAS SUPPRESSOR PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00019">
        <property type="entry name" value="LEURICHRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="3" id="KW-0675">Receptor</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5106181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="312" mass="36164" checksum="BA6077E27869B1C2" modified="2022-05-25" version="1">MPSITHLYLGKNDLESVDFLKNFPQSLTHLDLHANEIHSFDVGKPANRLKVLNFNENKINKLCGPHDQIYDSDCWGMRLRRLKQLQCLSIVNVGLEYIATDSLENLSELIYLDMSENKISEINNALNNLVQLKTLILENNQLIDIPNISNLKNLEYFSVSNNNLTSLKRYNFDNLLNLKILKLSHNGLTEIIPGTFNKLVSLEVLDLSSNKLQILPNDWITPKIKLKYLFLNDNLLTSFQSSSIIKIKTLQHLNIGNNPLRFMINLQTLWSLPENLTMDVEVEQYFELPSMPNMRNKIWTDEIRTMTMRDFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MT76</accession>
    <name>A0A8J2MT76_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Large ribosomal subunit protein bL27m</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">39S ribosomal protein L27, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HICCMSTLAB_LOCUS12433</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bacterial ribosomal protein bL27 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5106784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MT76"/>
    <dbReference type="OrthoDB" id="1867012at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.100:FF:000031">
        <property type="entry name" value="39S ribosomal protein L27, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001684">
        <property type="entry name" value="Ribosomal_bL27"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15893:SF0">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN BL27M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15893">
        <property type="entry name" value="RIBOSOMAL PROTEIN L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01016">
        <property type="entry name" value="Ribosomal_L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00063">
        <property type="entry name" value="RIBOSOMALL27"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110324">
        <property type="entry name" value="Ribosomal L27 protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="33"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="39"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00076963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAG5106784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="152" mass="17412" checksum="E018A5BB04E6632B" modified="2022-05-25" version="1">MSMISQTVFSTLRNIKQNLLTPAIVTHNHVVVRNKTRNTRSTTQNRGGNKTRPYHRGWKCQDGEVVTGGTLLATQLIPRWHPGLNVGFGKNGTLFAIVPGKVVVTCEKCDLNWNHTWVQRHYSDRKGEVIYKKHFNIIPEKQHDRFKLVDAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MTQ7</accession>
    <name>A0A8J2MTQ7_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Quinone] (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS12841</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5107633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MTQ7"/>
    <dbReference type="OrthoDB" id="269227at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF217">
        <property type="entry name" value="GLUCOSE DEHYDROGENASE [FAD, QUINONE]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00624">
        <property type="entry name" value="GMC_OXRED_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="2">
        <location>
            <begin position="316"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="2">
        <location>
            <begin position="929"/>
            <end position="943"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5107633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="1224" mass="133819" checksum="22FB62FB089AD654" modified="2022-05-25" version="1">MSYNVSILSECVEPFLGPSLAQICPGSQFLLFMTLLDTFIRTNPEVSQLCNRVFPTNPADYYYDFIVIGGGSAGAVVAARLSDVPEWKVLLLEAGPDEPPGADIPSMVAMFLGTELDWQFKTTNEENACLSTNGSCGWPRGKNLGGSSVHNGMMYIRGHAKDYDDWESMGNEEWGWRDVLPHFVAMEDNGDIDILDDKYHGTGGPLRVEKFPWRPSISNDIIRAAEERGFGLSSDLNGDTITGFTIAQSTSKNGVRVSSASAFLRPIRNRRNLHIALNATVTKILIESRKAVGVQYIQNNELRTARSIREIIVSAGAIGSPHLLLLSGIGPKKHLKEMGVPVVQDLPGVGENLQNHVSYTLTYTINQPNEYDLNWAAALEYVSRQRGPMSSTGMSQITGIMSSSYSTPDHPDLQFYFGGFQATCATTGQIGMLIDNTQRSISISPTNLHPRSRGFIHLADNNPLSKPIIQANYFQDPEDVAVLIEGIQLAISLMNSSELSKLNLTLMNPSVQVCSQFMYLSNEYWSCVVKQDTGPENHQAGSCKMGPVSDSMSVVSSKLKVHGIAGLRVADTSIMPKVTSGNTGAPAMMIGERAATFIKQEWLRLRGPWGPIIFNSSTICQNQFLGGPSLTEVCPSTTATYVFFLYIVNNIIDTIPTIGDSCGRVTADKKPRDVYDFIVIGGGAAGSVVAARLSEIPSWRVLLIEAGPDEPAGAEIPSNFGVYLGSSLDWKYRTTNESYACLAQNGSCSWPRGRNLGGTTVHHGMAYHRGNAKDYENWVAMGNEGWSWAEVLPYFIKSEDNREINRVGRQYHGTGGPMVIERFPYQPSFADAILKAAEETGYGRTEDMVGANIRGFTVAQTMSVNGVRQSTASAFLRPIRNRENLDIVLNATATRLLINNQKRVTGVEYLLNNRTRRARVTREVIVSGGAVNSPQLLLLSGIGPKEQLRSLGIRVVLDLPGVGKNLHNHVSYSLDFTLANQQNALGFNLDDVTQYMSNQTGPLSSSGLAQVTGILSSRYTTSDNPDLQIFFSGFQESCLDTGDVDLRSYGNNRTVRFTAVNLHPKSRGAISLASKNPLEHPIIWSNDLADPADVDVLVDGMHVIINMANSTTMKSQGLTLATQPIDRCKEYEFLSDSYFRCAVHIDTRTENHQTGSCKMGPTSDPLAVVDPYLRVHGIQGLRIADASIMPMVVSGNPQAPVTMVGERAADFIKRTYTANAHAYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MU39</accession>
    <name>A0A8J2MU39_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similar to Dap: Death-associated protein 1 (Mus musculus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS13146</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5108255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MU39"/>
    <dbReference type="OrthoDB" id="5973225at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070513">
        <property type="term" value="F:death domain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097190">
        <property type="term" value="P:apoptotic signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034198">
        <property type="term" value="P:cellular response to amino acid starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010507">
        <property type="term" value="P:negative regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024130">
        <property type="entry name" value="DAP1/DAPL1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13177">
        <property type="entry name" value="DEATH-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13177:SF4">
        <property type="entry name" value="GEO09647P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15228">
        <property type="entry name" value="DAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5108255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="102" mass="11039" checksum="F29846F2BC69E810" modified="2022-05-25" version="1">MSSPDECKLKAGHPPAVKAGGMRITQHKTPRDEREAKPSKDSIESKPSSSPPKTIMISGAPAKGNADFPPEAIQHFHEKPTPTHDARSANSSRPIVIQQPRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MU46</accession>
    <name>A0A8J2MU46_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to LIPE: Hormone-sensitive lipase (Sus scrofa)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS7896</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5095814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MU46"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004771">
        <property type="term" value="F:sterol ester esterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008203">
        <property type="term" value="P:cholesterol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019433">
        <property type="term" value="P:triglyceride catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010468">
        <property type="entry name" value="HSL_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23025:SF3">
        <property type="entry name" value="HORMONE-SENSITIVE LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23025">
        <property type="entry name" value="TRIACYLGLYCEROL LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06350">
        <property type="entry name" value="HSL_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hormone-sensitive lipase N-terminal" evidence="1">
        <location>
            <begin position="25"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="2">
        <location>
            <begin position="347"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="2">
        <location>
            <begin position="646"/>
            <end position="707"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5095814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="733" mass="81775" checksum="153B9F660D7F24EF" modified="2022-05-25" version="1">MSPDDELTLPLEADDANQERDPPLWRVLHELASSNLDFFSKHLDENGLRIHAAHIVILDNYNEFRELYKEISDIAPQFDFDEITPGNGYRSFLKLVDQCLLHTGGVCRHIFSYKDSVLFRKSNYMREIEACSQLIVALKTFLHHLKTLYSWSELASDGKLSLFPSDEHSPQELLNQAGNIDQYCFYGRCLAFQFVDSIKYVLKTLLSSMATFSEIYYSNGSLLNRCTQSVKYFIDPEARARRVVNISQRAEVDFCKSFWMLNEADIVQFVPLMLMPSLPINQVISIPPEELTLPSIDGTDVKIPIPNSHIGKKPIHVRLLSAKRRIGMVGSARASGELFGSSDVLLFHCHGGGFVAQTSKSHEPYLRSWAIELDAPILSVDYSLAPEAPYPRAIEEVVYSYAWALKHASSLLGSTAKKIIVIGDSAGANLNLALTTKCIEMNIRKPDGIFMAYVPVLVEFVPSPSRMLGLTDPLLPFGFMMRCLKAYTLGDTRTCVKDKEADIESTPSDTDSFAEVSESDLIALALSPNGDEAGSKNKLASLPSDSTLNSVSLVDVDATQVPQANSTTESSQDYIQRFFDFYKNAAARLSPSSANSVANNYDNYSDSNTSVGFFGLSFNKSNQKLRELDDEDSKSPSEEFVFTVPRDPLLSPYRSSDDLLRKLPPTKILTSEFDPCLDDCVMFGRKLKQLDIDVSLDIVKGLPHGFLSLSVMSKEALEGSELCIKRIKQLMNM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MXT4</accession>
    <name>A0A8J2MXT4_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS11932</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5104298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MXT4"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="95"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5104298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="235" mass="25655" checksum="18680A399B701E30" modified="2022-05-25" version="1">MFLCVNVARKDSRVQHLVVFWISFSFFLCRNSVSRAFVSLRHMLANFIFIKLIKNTNLSSSFSSDHSTSFLAASSSAVGTIGVMLKVFLISSGVLPLIMLATVLQVTSMSPLMSRKLAARMMAKSVCWSTFRKSTSHSGISSDLFSWLSSNSGLSSSSTCFLHHSTTFSRIVPLTFVTGITSSLTSPSMPRVSSITLMVADINATLISTSKICSSLLWSCTVASMLDMVYLTHKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MYS3</accession>
    <name>A0A8J2MYS3_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to AASDH: Beta-alanine-activating enzyme (Homo sapiens)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS11936</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5104306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MYS3"/>
    <dbReference type="OrthoDB" id="408177at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043041">
        <property type="term" value="P:amino acid activation for nonribosomal peptide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052091">
        <property type="entry name" value="Beta-ala_Activ/Resist"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018391">
        <property type="entry name" value="PQQ_b-propeller_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002372">
        <property type="entry name" value="PQQ_rpt_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44394">
        <property type="entry name" value="BETA-ALANINE-ACTIVATING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44394:SF1">
        <property type="entry name" value="BETA-ALANINE-ACTIVATING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13570">
        <property type="entry name" value="Beta-prop_ACSF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00564">
        <property type="entry name" value="PQQ"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="1">
        <location>
            <begin position="139"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="domain" description="Pyrrolo-quinoline quinone repeat" evidence="2">
        <location>
            <begin position="645"/>
            <end position="967"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13570"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5104306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="971" mass="110335" checksum="91A5B8AF30565CCF" modified="2022-05-25" version="1" fragment="single">CKRQKIQEDDLIQITNWENFDKIALEHYSDADLFTLKYSQVYEAQNDIKNFLKELDYSEFIGIYYDTPIYCITSLILGILSSGRSFVYISKNEADFLKESLGFRYIFHLESNKIHGEQIKVFELHQQPIILSKTPSFFSKELNNNSKFAYAVTTSGSTGQPVVVRVTHKSILLNIQDFKNILKLSSTDRVAQLTPLTFDPSYVEIFLSLIIGATLCTFAEDLKNHPDILLKVLYNKKITFISTTPSLFLHRWRLKDLEETLLSKESCLKFLLIGGEPFPDLKLIRKIKHPENCTRIFNVYGITEVSCWASINEIFFNENYSEADCSNNLGTVLTDTLFQVREKNSNEIVKDGEGILYIGSSSRVCLLGKEKLSDLKLPVYRKTGDIVTVNKNKVTFKGRLDSCVKRFGTKVHFDKLKNHLQKLNFIKDVQLIFDNNLSVLNLFFTSELDDQKDNLVANVWSHVKLLPAIMHPDKIYYLESFKVTDRGKICKDYLKDFCSRPMSGSDAGSLLEQIWRDHLPGEQDKFGFLDLGGTSVIALQISSNLSSESGNNYPELIGMLFDNKTLLECKDYLCKNFNNVNTSSKVLNLTKLNFTSKNYLLDTYIWQKCRGRTVIINPESSDLLLDCKSDHENLKSIKLGNVFNLNKCVDASPTIFGYSNDQSFANVSSHSGLILTVDLKTKENWKIQLPNRIEGSTLVIDNFKGIVGCHDGFIYCLHLKSGHIFWSFKTGNIVKCLAAVCSEKINIFIGSYDHFVYCISLEGSLVWKLKLDGSTLATPLVHTETNAVIFSLLNSNCISVDQKSGKVRWKYQCKSSIFSTPNILSNKLILADVCGNISGLDINTGNELWIFSISGNIFSDIVICTDATANSFMFTSKNGFFYKYYFHETQHPELHYKVDLGSSVVATPWVEKDFAIIVRENGDLRVINMKDGKFLYNFILSGDSFSSPVLHNNFIVVGCRDDNLYTLYLQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2N0V5</accession>
    <name>A0A8J2N0V5_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">E3 ubiquitin-protein ligase</fullName>
            <ecNumber evidence="5">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HICCMSTLAB_LOCUS14012</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="5">E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="5">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="domain">
        <text evidence="5">The RING-type zinc finger domain is essential for ubiquitin ligase activity.</text>
    </comment>
    <comment type="domain">
        <text evidence="5">The SBD domain (substrate-binding domain) mediates the interaction with substrate proteins. It is related to the TRAF family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the SINA (Seven in absentia) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="5"/>
    <dbReference type="EMBL" id="CAJNRD030001247">
        <property type="protein sequence ID" value="CAG5109376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2N0V5"/>
    <dbReference type="OrthoDB" id="941555at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031624">
        <property type="term" value="F:ubiquitin conjugating enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.210.10">
        <property type="entry name" value="Apoptosis, Tumor Necrosis Factor Receptor Associated Protein 2, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018121">
        <property type="entry name" value="7-in-absentia-prot_TRAF-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004162">
        <property type="entry name" value="SINA-like_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008974">
        <property type="entry name" value="TRAF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45877">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE SIAH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45877:SF2">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE SINA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03145">
        <property type="entry name" value="Sina_TRAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49599">
        <property type="entry name" value="TRAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="4 5" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Seven-in-absentia protein TRAF-like" evidence="6">
        <location>
            <begin position="2"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU201113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAG5109376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="68" mass="7716" checksum="6E2DE6EA0FD40D0C" modified="2022-05-25" version="1" fragment="single">RKQAENFSYRLELNGNRRRLTWEAMPRSIHEGVCCAILASDCLVFDTSIARRFADNGNLAINVTISMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>S6CVL2</accession>
    <name>S6CVL2_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cc_RNAseT2.1_23.4</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="8">Hypothetical ribonuclease RNAseT2-like1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">RNAseT2-like1</name>
        <name evidence="7" type="ORF">HICCMSTLAB_LOCUS6070</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2013" name="Philos. Trans. R. Soc. Lond., B, Biol. Sci." volume="368" first="20130047" last="20130047">
            <title>Functional endogenous viral elements in the genome of the parasitoid wasp Cotesia congregata: insights into the evolutionary dynamics of bracoviruses.</title>
            <authorList>
                <person name="Bezier A."/>
                <person name="Louis F."/>
                <person name="Jancek S."/>
                <person name="Periquet G."/>
                <person name="Theze J."/>
                <person name="Gyapay G."/>
                <person name="Musset K."/>
                <person name="Lesobre J."/>
                <person name="Lenoble P."/>
                <person name="Dupuy C."/>
                <person name="Gundersen-Rindal D."/>
                <person name="Herniou E.A.Drezen.J.M."/>
            </authorList>
            <dbReference type="PubMed" id="23938757"/>
            <dbReference type="DOI" id="10.1098/rstb.2013.0047"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the RNase T2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5092344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="HF586472">
        <property type="protein sequence ID" value="CCQ71094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S6CVL2"/>
    <dbReference type="OrthoDB" id="435754at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033897">
        <property type="term" value="F:ribonuclease T2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006401">
        <property type="term" value="P:RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.730.10">
        <property type="entry name" value="Ribonuclease T2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001568">
        <property type="entry name" value="RNase_T2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036430">
        <property type="entry name" value="RNase_T2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018188">
        <property type="entry name" value="RNase_T2_His_AS_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033130">
        <property type="entry name" value="RNase_T2_His_AS_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11240:SF75">
        <property type="entry name" value="RIBONUCLEASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11240">
        <property type="entry name" value="RIBONUCLEASE T2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00445">
        <property type="entry name" value="Ribonuclease_T2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55895">
        <property type="entry name" value="Ribonuclease Rh-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00530">
        <property type="entry name" value="RNASE_T2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00531">
        <property type="entry name" value="RNASE_T2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036287016" evidence="6">
        <location>
            <begin position="23"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="24"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="232"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="43"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="73"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="97"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="144"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="182"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="233"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAG5092344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCQ71094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="527" mass="58394" checksum="37FB39C69139798C" modified="2016-04-13" version="1">MKCNKRLLVCLIFQTLLIISEAGRNSKPKNPKSPIPGLGLGSRGTSPGRSNSGRISPTQTNFGGYSGWGASHPNRAPVQPAPVRVRPGVNPHFPATLPSNSPPASSATVWFKFRPPGTSSRPNTRLRPENPLNPGSFRPLNPLNPGSFNPQSPVNSGSFRPQSPVHSGSFRPQTPVIPGSLRPQSPGTTIQSWSSVPSIDHAQSSTHNLFPALRAPKLTYVEAEKRGSDILKSSSSTSLSSGSSGFNSGSGRSSFSSVGSFSSGSSGSLYRPQTIGLNAIKSTAVRRSRASPKLCVDNTATMQKIIAPAEHCFDYFKLAVAWSPSYAYKERKKGLEVRDKIRPAWFIHGLWPAMFERFQDPMPGCQRHDISFNYNRFVDHKILGPLENTWYTVLAKGWSDNKKFWEHEFKKHGSCASRSSIIGDDVNYFKRTLELFNQLNIGTTLYENRLRQGDTVNLKNIIYSIEDRIGATIQYDLVMNDNTHDLYLTELTICYDTNLRVMDCPNVYRNDDDLNLKIEYLDSLPKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-10-16" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>S6CWM8</accession>
    <name>S6CWM8_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Cc_p94.2_7.2b</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">p94-like2</name>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS6246</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Philos. Trans. R. Soc. Lond., B, Biol. Sci." volume="368" first="20130047" last="20130047">
            <title>Functional endogenous viral elements in the genome of the parasitoid wasp Cotesia congregata: insights into the evolutionary dynamics of bracoviruses.</title>
            <authorList>
                <person name="Bezier A."/>
                <person name="Louis F."/>
                <person name="Jancek S."/>
                <person name="Periquet G."/>
                <person name="Theze J."/>
                <person name="Gyapay G."/>
                <person name="Musset K."/>
                <person name="Lesobre J."/>
                <person name="Lenoble P."/>
                <person name="Dupuy C."/>
                <person name="Gundersen-Rindal D."/>
                <person name="Herniou E.A.Drezen.J.M."/>
            </authorList>
            <dbReference type="PubMed" id="23938757"/>
            <dbReference type="DOI" id="10.1098/rstb.2013.0047"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5092598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="HF586475">
        <property type="protein sequence ID" value="CCQ71305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S6CWM8"/>
    <dbReference type="OrthoDB" id="8120898at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5092598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCQ71305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="586" mass="69589" checksum="44A4BD7C77607BD2" modified="2013-10-16" version="1">MITRQTSKVLLKNTIYLIRLREATYFIRLNTFLVESSHSSSFAPTCYVMPFECRTVNTASNRHFVNSVWNRALYDQEVPKVSSSLKMVDYFIYAEDCSDSINRAEYYHSNNLKTLEQFKCDVESIKEQSVAQEPTRQFKIVYLNWSDVCWEVNEDKVGMNNYTNGDVTGLSNVHTCERRDPRCLIRYFRKNYIVCENDRIKLLYIVTNGKISRESIDECLELNKEIDYEMVVFHAFNEDPEKIDLLVAAPFFKSRCIVYHNTELCNRTHISKEFDYDKISSDNFAVEMQQLMSYIKLKFINKFKRDADVWREIEKLHNLRNRMLRELSENTPKCPFFERMEEKERKILLRTFDVNKFKNYMAMAYVMKTDVEKYVAAMVNYIKSNKKSCSLDVLKFDSKVNESVEEKQIDDADSTDDEESNFFLIVDEEMHGYRIGQFKDSRWINYQYVGRVTLSSILITLDMISDNPPIMTMFTELPSISTESKNYVLLRKNPDLTDYLMYVSARKKFYGDLVTLFPSNVLFEMKDMHECYQKVVKKVGVEEFLEVSEPHFMQMKRIKEKERSMHRKRETGFITISFSNFTFRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2E0P2</accession>
    <name>A0A8J2E0P2_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="6">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HICCMSTLAB_LOCUS321</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="6"/>
    <dbReference type="EMBL" id="CAJNRD030001114">
        <property type="protein sequence ID" value="CAG5073378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2E0P2"/>
    <dbReference type="OrthoDB" id="19653at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43142">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43142:SF1">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0719">Serine esterase</keyword>
    <feature type="domain" description="Carboxylesterase type B" evidence="7">
        <location>
            <begin position="3"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG5073378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="361" mass="39705" checksum="29FF76E0E5807E47" modified="2022-05-25" version="1">MESPIVEVEQGQLSGTRENNINGVDFYAFKGIPFAKPPVGDLRFKDPEPADPWKSIRDASKFGDKCAQNDLFTKEMTGSDDCLYLNIYTTELKPAVPRAVMVWIHGGAFYSGSGNDDIYGPDYIVEQNVVLVTINYRVGIIGFLNLDDEEAPGNQGLKDQVMALKWVKQNIEKFGGDSSNVTIFGESAGSASVHYLTLSPLAQGLFHKAILQSGVATNTWASALYSAKEAAVEVSAVLGNRITDTKELIKFLRSVDALQLKLHLFENPFIPSVDSKSKTPFLNIPVIEAAKAGIRVPHIIGYTSHEGIVFVPTESSYAEIEANPEELLLHRTIKKFLKERNICERYQGVLHGGKGIQVGKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2E205</accession>
    <name>A0A8J2E205_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Similar to CG1139: Proton-coupled amino acid transporter-like protein CG1139 (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HICCMSTLAB_LOCUS1108</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001116">
        <property type="protein sequence ID" value="CAG5074891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2E205"/>
    <dbReference type="OrthoDB" id="1684102at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF349">
        <property type="entry name" value="AMINO ACID TRANSPORTER TRANSMEMBRANE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="92"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="117"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="175"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="212"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="236"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="278"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="311"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="352"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="397"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="425"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="461"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="6">
        <location>
            <begin position="91"/>
            <end position="482"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAG5074891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="492" mass="54469" checksum="D27C2DE0D2C3DF0E" modified="2022-05-25" version="1">MTEVERANEEPFDPYRRDANKKYLSHSALIEYPHGLSAVTFRVCVTHDAHVLHQRQPRLMGIQVTGNFPESTKIIKRKEIIELFSSRDFGSFMNLVKSAAGAGLFAMPYAFASVGMILGVVGTLLMGVLITVALHLLIITHTRLCTEQRRRAIPYDQLVAATVARGRLSTNTARLVIDIIMLICYIGIGAVYIIFVSGIIQDLVDQGKTVGLAYYSLILFPLFLLLNMIRGLNAIAPVAIIGNVLIVVAAFIGVAYAVVKAESDWVFFQKDYQKYPKFLGTVFFALSSPALALAIQQDMQRPRHFTRKCGVLNWGMGFLILLHLSVGIVGYAKYGSSVTGNFVQNHPILDTVTGIALGVQALAIFFSYGLQCYLPISILYKDYAVRSIQDRFLRGTPFLWSILIRVSVTLLTCILAASIPQLHVFASFVGALCVATLGFIIPVMVYMISHYGEFGRFKWKLVLSIVFLILGTLAMILGTISSVKSMIDYLKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2EBP6</accession>
    <name>A0A8J2EBP6_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Similar to dph2: 2-(3-amino-3-carboxypropyl)histidine synthase subunit 2 (Xenopus laevis)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HICCMSTLAB_LOCUS2016</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; peptidyl-diphthamide biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DPH1/DPH2 family. DPH2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001116">
        <property type="protein sequence ID" value="CAG5076035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2EBP6"/>
    <dbReference type="OrthoDB" id="449241at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090560">
        <property type="term" value="F:2-(3-amino-3-carboxypropyl)histidine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017183">
        <property type="term" value="P:protein histidyl modification to diphthamide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11860:FF:000001">
        <property type="entry name" value="2-(3-amino-3-carboxypropyl)histidine synthase subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11860">
        <property type="entry name" value="Diphthamide synthesis DPH1/DPH2 domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016435">
        <property type="entry name" value="DPH1/DPH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042265">
        <property type="entry name" value="DPH1/DPH2_3"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00322">
        <property type="entry name" value="diphth2_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10762:SF2">
        <property type="entry name" value="2-(3-AMINO-3-CARBOXYPROPYL)HISTIDINE SYNTHASE SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10762">
        <property type="entry name" value="DIPHTHAMIDE BIOSYNTHESIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01866">
        <property type="entry name" value="Diphthamide_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00032">
        <property type="entry name" value="Radical_SAM_3-amino-3-carboxyp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAG5076035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="284" mass="31991" checksum="21324EA08A1B1931" modified="2022-05-25" version="1" fragment="single">MTPSNHLDKNQTDSSNLDTSNRLNNYYINDCVQWIKARGLEKVYKMRHSLSDKIHRTLITGRELLKVEKLEEYVGFYLGDDNKTLASLALSIPVKNWFYCTGKISGCDNDKMEIKEFEVAKNPWLRRRRFLVEKLKDAKVVGIVVATLGIKNYLDVLDMVKSILKSKNIKSYIFSVGKPNPAKLANFAEVDAFVVIACPENEIFDSSDEPTDAEKMKTLVCKNDGTVAIGKAGADFLLNRSWQGLEQKLGETEIMTAVKGRHGLPISYDTEPVIDKSSDPFGSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2EBX6</accession>
    <name>A0A8J2EBX6_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Set2 Rpb1 interacting domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HICCMSTLAB_LOCUS2138</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001117">
        <property type="protein sequence ID" value="CAG5076313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2EBX6"/>
    <dbReference type="OrthoDB" id="6594281at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013257">
        <property type="entry name" value="SRI"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08236">
        <property type="entry name" value="SRI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Set2 Rpb1 interacting" evidence="4">
        <location>
            <begin position="473"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="219"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="23"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="232"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAG5076313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="542" mass="62328" checksum="76FF016C21C3710A" modified="2022-05-25" version="1">MTATKPLEIPLPLKIKKEKEESISSEDCDNDDLDTDSDSTSSMLLQPSIFQNDSLSRIDPNNFLRLTSMVRRIYFSYLYKSIVKNYNTCCRSIKSEKFLRCDLKKFSSLLELDAVKASIETSLYRQAVLKIISDVKKDTVNNKIHNKLAVYLDTPSKTVDVAVQTCSEELEDNYSVLNCGGDNVIINNTQQDINYPYLLNSVPVFDEVNSLLSDRLYEQSGERETLDDGEELNNTSVITSQQENSQDRVSKNIADLFGNNSSSNIDDNNDQDNFNDVDNIDEDTHDTLVQNLETMFGESDDSSDLMALIEKHSSINKPSIDMEPTNTAKIINYSKNTTSNFTLPSENNSNSCVSFDKLDDKKTKIKEFKVNYGGKRKVSFTDYKKLKKRALEDNKTEDKQTKKMRNVWLVERIHQESKLRTKMLELSLNNYRKYGKVKEKFKELFGEENDDEEMMPAESPIHIEEHLNGCKERIAPWVVKYLMPYYEEKISGNKLLFKAVAKHVSDKLILENTFPEEACVNNYIKDYFKNKTCIKTEADVYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2EC84</accession>
    <name>A0A8J2EC84_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Similar to Glod4: Glyoxalase domain-containing protein 4 (Mus musculus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HICCMSTLAB_LOCUS2303</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glyoxalase I family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001117">
        <property type="protein sequence ID" value="CAG5076862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2EC84"/>
    <dbReference type="OrthoDB" id="1545884at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd16357">
        <property type="entry name" value="GLOD4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08358">
        <property type="entry name" value="GLOD4_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="entry name" value="2,3-Dihydroxybiphenyl 1,2-Dioxygenase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043193">
        <property type="entry name" value="GLOD4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043194">
        <property type="entry name" value="GLOD4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059155">
        <property type="entry name" value="GLOD4_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC_core"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46466">
        <property type="entry name" value="GLYOXALASE DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46466:SF1">
        <property type="entry name" value="GLYOXALASE DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21701">
        <property type="entry name" value="GLOD4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21207">
        <property type="entry name" value="GLOD4_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="VOC" evidence="3">
        <location>
            <begin position="4"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="VOC" evidence="3">
        <location>
            <begin position="136"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG5076862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="281" mass="32030" checksum="97AC3F04CC3AD582" modified="2022-05-25" version="1">MAARALHYVFKIPDRKLTVKFYREILGMKVLRHEEFSEGCDAACNGPYDSRWSKTMIGYGPEDSHFVIELTYNYGINNYELGNDFQGITIKSKDIIDRARKHNWPVEEENGVSVLKAPGGYKYYIINEPQVANQDPVVKVTLSSSNLQRTVSYWKDILSMKVYEQNDNNVTFGYDDNQAKLEFKNIGTKVDHGKAYGRIAFSVPYDSQPGIQKKIRENGHKILTDLITLDTPGKASVRVIILADPDEHEICFVDDEGFRKLSVPDYPSEAILDRFIAKEST</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2ECQ5</accession>
    <name>A0A8J2ECQ5_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS1710</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001116">
        <property type="protein sequence ID" value="CAG5075556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2ECQ5"/>
    <dbReference type="OrthoDB" id="7616539at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5075556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="84" mass="9636" checksum="826CD799C6464D35" modified="2022-05-25" version="1">MYNNVGLNVARKDLEEQLFEAVKSGKTTYVIGDINARVGEETGYIDSEWEEHVGEIRRSQDKTINTEGRKLLKICEEWGLYIAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2ECY3</accession>
    <name>A0A8J2ECY3_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS1831</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001116">
        <property type="protein sequence ID" value="CAG5075727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2ECY3"/>
    <dbReference type="OrthoDB" id="7679028at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5075727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="233" mass="27297" checksum="D9DC096B938CCC88" modified="2022-05-25" version="1" fragment="single">KRLLEFCFSDRLNPLIITEDLYDKIHKILWEIVEPPIIILDKNFKSKEIQVFNPRYPTYVLSVSESIQNLKTLFDKLKSTTTWSVESFFFIVEVNNFCDNANEVLKLLWKMDLLSSFYLCQESDSYNLTIYNYNPFTNYVPYPWRSAETTGQKITEKGTLFHQHFDNDRNVCHNITFDKSKTLGNHKIKTTMAYPVQNATRDDVIDISNFTNIVNPRISSVSSFFDLLNITPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2EEV0</accession>
    <name>A0A8J2EEV0_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS2260</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001117">
        <property type="protein sequence ID" value="CAG5076723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2EEV0"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5076723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="70" mass="8252" checksum="0A66AB69EC7F4D8E" modified="2022-05-25" version="1">MKLLDENGIRFNQKCNANNSPYNYRDIFYWSNVHQRLKRDLGKFDNKVTDLGKISCLNTPGMYGNLIEHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2EF24</accession>
    <name>A0A8J2EF24_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similar to mam: Neurogenic protein mastermind (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS2365</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001117">
        <property type="protein sequence ID" value="CAG5077078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2EF24"/>
    <dbReference type="OrthoDB" id="5982619at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20802">
        <property type="entry name" value="MAML1_3_TAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="137"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="249"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="322"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="47"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="250"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="269"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="281"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="322"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="379"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="393"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="478"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="488"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="503"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="526"/>
            <end position="535"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5077078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="535" mass="55676" checksum="95AD71596F63A36E" modified="2022-05-25" version="1">MNKISLTKMLLFQQQKILKRTAEDLESSGGSTVEPNFGEPPVKVQCTQGQQHQHQQTQSSSSSGHHPMNQLPSGNNSSSSGQPAPGSTSSSNEGLTKFSVEIVQQLEFTTSAANSQAQQISTNVTVKALTNASVKSDLVNTSSPGPKADPSSRASSQGPGIGCVDIGNLVECKQEPDNDFVDLEQCAAAVVKDAAANGAGFPGFSDFIDETGDEMLNADTFKDLISEINDYPLMDEFDFDDKGIESLTVNHGSSGNSGNSVPGLSNGIKLEDDKDVHSHNHQNGVANGSLASNSSPGLGAQYSPRLPYSSLDFKSEIQSPAASTLKQMAEQHQNQQHKNQMGLGPFTPAGNPARGPASRSPYTEFPQFGNPEYLGSPGSNGTSGTGNQNAQNSVAASYHKSTSNPGFQSQASDMFANQAPFSGLGDMKRSQSMTGKPNMLGPSGYKQQYSPYGSPGSMPNHGSPGYPLPSRGAPGPGPNQGGSGPGPFTGSTPPRPPSGSGSATLQINQAQQLHISNPGHNIQGVEGVGGLREEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2EHZ2</accession>
    <name>A0A8J2EHZ2_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Similar to Tulp4: Tubby-related protein 4 (Mus musculus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HICCMSTLAB_LOCUS2096</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TUB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001116">
        <property type="protein sequence ID" value="CAG5076115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="8775810at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.710.10:FF:000159">
        <property type="entry name" value="Speckle-type POZ protein B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.210.10">
        <property type="entry name" value="Apoptosis, Tumor Necrosis Factor Receptor Associated Protein 2, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.90.10">
        <property type="entry name" value="Tubby Protein, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056159">
        <property type="entry name" value="Beta-prop_IFT121_TULP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008974">
        <property type="entry name" value="TRAF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025659">
        <property type="entry name" value="Tubby-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000007">
        <property type="entry name" value="Tubby_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16517">
        <property type="entry name" value="TUBBY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16517:SF2">
        <property type="entry name" value="TUBBY-RELATED PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24797">
        <property type="entry name" value="Beta-prop_WDR35_TULP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01167">
        <property type="entry name" value="Tub"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49599">
        <property type="entry name" value="TRAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54518">
        <property type="entry name" value="Tubby C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="BTB" evidence="7">
        <location>
            <begin position="179"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="865"/>
            <end position="907"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="977"/>
            <end position="1046"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1190"/>
            <end position="1215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1293"/>
            <end position="1329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1348"/>
            <end position="1467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="866"/>
            <end position="876"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="1009"/>
            <end position="1018"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1035"/>
            <end position="1045"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1348"/>
            <end position="1373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1404"/>
            <end position="1414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG5076115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="1575" mass="177294" checksum="997A3EA705F6A1AE" modified="2022-05-25" version="1">MLGSANPQINTIGCLVVAPSSVSSIFSTGGKNNDKWCLELAIEKENNESEEYSWVSLQLKLCNVKNYVRAKFFFFFVNSQKEKIMTDFEAYHHPVGDEYLIHCRFSKFRISNKFARFVKIDNLFEKIIEWSQNDALTIGVDLTVYDDYVPSDPSLTPLKAPSRSIGDDFKDLIAAKKKCDVKIKVGTEIFDAHKVILIAQSCVFDGMFSHNMKESEENEITIPDVDPVVFKKVFDYIYTDKVEDLDTFAEELLEASDKYQLLALREICEESLSRTISVENSIRRLVLADRHNSERLVDVVIKYVVSKLASLKDTEEYKALEESYPALFLAVLKEHVNRFGIDKWYVAVITLKDEGWKLNRANYYQEGWLATGNARGLVGVTFTTSHCRTRITENPLRANYNLRGHQSERKLSREEYRCQKYMDFRASKSDDATIRKMSSNKVILEMSKSLVSADGSRSTVMIRDEVINVILVKWNEPYQKLASCDSSGVIFVWIKYEGRWSIELINDRSTPVTHFSWSHDGRMALICYRDGFVLVGSVGGQRYWSSMLNDQATITCGIWTPDDLQVYFGTTSGQLIVMDVHGAMVSEVQLSAGITSMAWSAQKFRMEEGDLEDDDICGVQTQPDERTYVLAVCLTDGNIVMLRSYDDLSPITIKTGLKAPLFAEWSNSRELLAIAGTKESETSIANPPEYNNLLKFYSFTGTLIYTTTIPYTQGQVSALTWGHNDWRLFIATGAKVHAAWVSRNVGSLQLLATLAVRAALTRESSVQQLPLPRRLRAPVAALFASTIRSCVPEPRELRKFVSRPPPGGGRLHCTMLRHAGEPAPCYTLYLEYLGGLVPLLKGRRTSKIRPEFVIFDPQSQDTLQIPDYSFPSFSDSSDTERDTAELCGSPRNRRKNRRKKDDKSNDESDVLTYIDTLPEDGRLVEVTSNIWGTKFKIHGLTDSVPANLGQVTYRTSLLHLQPRQMTLVITELRDDLPAGPDPSFNPNLFSEDEEETFSEPQGASRPVDIPAPPAPPIAPMTSRGTRLNPAPRPKSQLSSQSQFISNPEVPPENFPFDEDFPYVANHFHHQNMLDFCENLRATSSNYRSSRHQPRCCDVPALQSPKNAVAPTQTLIATSNSSSDYSGNIQRVKTSLISEQSSIRKELEINKINQLDDKNVAASLPTSRCQTNGGSTSPIYVNFSASNGSFVHTKPSSHQKGKNLRTSGAQNGKTEREELRFIDEEAVAKEPELRSVHRTPTVVSIGPINPVLDPMVRSCSVGYLDLVDAQMVPCEVALKMLRKEAPNKRLVLVSRKTKRRKKKAQEGQARPRLRTCGKSRSLDSSDMFPSTEQILPVKLLEHVEEIEKREELGTSKEEDKREEKVLKETGDTKSSDSLSSSLDGLAARLRDFDDTNSLPPPSPRPNIRLPRSSPSSPAPTKKGKRPASASPIRRRLLSSPLLNRRTRKNRGESSDDEGPQDDSSSRSYRNLETFQKAQLRQKLKHRGNGVLANKPEELVMHNKAPMWNESSQVYQLDFGGRVTQESAKNFQIEYRGKQVMQFGRIDGNAYTLDFQYPFSALQAFAVALANVTQRLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2EI15</accession>
    <name>A0A8J2EI15_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Similar to NIPA2: Magnesium transporter NIPA2 (Bos taurus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HICCMSTLAB_LOCUS236</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NIPA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001114">
        <property type="protein sequence ID" value="CAG5073234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2EI15"/>
    <dbReference type="OrthoDB" id="6428174at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008521">
        <property type="entry name" value="Mg_trans_NIPA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12570:SF92">
        <property type="entry name" value="SPICHTHYIN, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05653">
        <property type="entry name" value="Mg_trans_NIPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="30"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="67"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAG5073234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="201" mass="23310" checksum="C35E48903745DFFE" modified="2022-05-25" version="1">MENYLTWFFLLSIIICIMIQMNYLNKALDLFNTAIVTPIYYVGFTSFVLITTSILFDEWKHMNIQNFICNLCGLFVIIIAIFLLNAFKDLNITYNNIKQLSINNSNFQRDCNSSGDFNNFDNDNNVLELNEERGAKGPLKMTTKTWKKGCHYSNIQENTTTTKYTSFTPLDLLLARSASTFHRELFNYRETKAKPIEAVVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2EJ60</accession>
    <name>A0A8J2EJ60_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS961</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001114">
        <property type="protein sequence ID" value="CAG5074206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2EJ60"/>
    <dbReference type="OrthoDB" id="8190053at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36694:SF11">
        <property type="entry name" value="LP21121P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36694">
        <property type="entry name" value="PASIFLORA 1, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="95"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="126"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5074206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="164" mass="17527" checksum="558A25EB1FF1AA11" modified="2022-05-25" version="1">MAIKVLEKCCCFDLKTGVLIIGIFSIVVSVGGLIEAPVSYSQACSGGATPQNNQECAAASSKLGGSISSEVIGIILMGLMIYGSQKESYGLMLPIIILQAIGIIIIFLFVWYLTIVFFTVSVGTGFLFMILGNAIVGITVYLWLVIYSRCQEIKNMTYSAANTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2EK47</accession>
    <name>A0A8J2EK47_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS1531</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001116">
        <property type="protein sequence ID" value="CAG5075377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2EK47"/>
    <dbReference type="OrthoDB" id="7996068at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2590">
        <property type="entry name" value="BEN domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="162"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="176"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5075377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="329" mass="36895" checksum="1DB3EA8BED8B792C" modified="2022-05-25" version="1">MFVIKSKELKTNVNVVSEDIVGDPASLKIEDETKFFYKSKIYTGRVIKKTDPKLKRKRDKKRSYSPSDYDKKSNKSKENDKQAKKSKKLKKDESSSSSENSEDDSKSKKDEVSDISSLEDSTENLEKPKRTGKVDKHSSRRDDSSDRSALNKKDSLPKEGKNTSSKTDSPSACENSTRESTKNDEVDNNGRELEVQQSSLDNDDHLLGVASADMVLLKNNIYVKKTVLDTAKRTSSQASHLARQLLEGVIKAEILQRSTLTGKAMRGKKDPNVLPLHGGAKDAIVAYAQEIAREKHWTAQDVKTIEKSIGQKLTEIRNAHKKNLEIRQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2EKW6</accession>
    <name>A0A8J2EKW6_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Similar to fpaA: SCF ubiquitin ligase complex protein SKP1a (Dictyostelium discoideum)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HICCMSTLAB_LOCUS2019</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the SKP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001116">
        <property type="protein sequence ID" value="CAG5076038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2EKW6"/>
    <dbReference type="OrthoDB" id="2342932at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016897">
        <property type="entry name" value="SKP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001232">
        <property type="entry name" value="SKP1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036296">
        <property type="entry name" value="SKP1-like_dim_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016072">
        <property type="entry name" value="Skp1_comp_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016073">
        <property type="entry name" value="Skp1_comp_POZ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11165">
        <property type="entry name" value="SKP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01466">
        <property type="entry name" value="Skp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03931">
        <property type="entry name" value="Skp1_POZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028729">
        <property type="entry name" value="E3_ubiquit_lig_SCF_Skp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00512">
        <property type="entry name" value="Skp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81382">
        <property type="entry name" value="Skp1 dimerisation domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0436">Ligase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="SKP1 component POZ" evidence="5">
        <location>
            <begin position="5"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="domain" description="SKP1 component dimerisation" evidence="4">
        <location>
            <begin position="110"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR028729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAG5076038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="160" mass="17994" checksum="A0A3C6B639398E20" modified="2022-05-25" version="1">MADLELISADGKIFPVDKDVVNNWVTVTEMLELLQGESDSQVHLPAVNGSELKKIIDWSRANGGNLPRPNAEGDPVTVQLTEADQFYFASIENGELINVINAANYLGIERLLDVTTQLLADRIRVKEPHQIRAEFNLVNDLHEEDRAVLREEYELISNEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2EL77</accession>
    <name>A0A8J2EL77_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS2231</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001117">
        <property type="protein sequence ID" value="CAG5076607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2EL77"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49599">
        <property type="entry name" value="TRAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5076607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="145" mass="16203" checksum="3CA5F35E47FF4D37" modified="2022-05-25" version="1">MEPIELKSSQKDVQSVDKKWLSIFLMLSTESSVEAKTKYLCVGGWGNRKFLETNELLEKKDELVPNNTLTIGIELTVFDSFTTISNSLFGCLNQEHQRSLAADDFKGSAIQTILQAISKAPNVDLLIKRILNTIQLDCQHGSKKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2EMT8</accession>
    <name>A0A8J2EMT8_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similar to Rasl10b: Ras-like protein family member 10B (Mus musculus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS1060</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001116">
        <property type="protein sequence ID" value="CAG5074827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2EMT8"/>
    <dbReference type="OrthoDB" id="299781at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052661">
        <property type="entry name" value="Ras-like_GTPase_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46350:SF2">
        <property type="entry name" value="RAS LIKE FAMILY 10 MEMBER B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46350">
        <property type="entry name" value="RAS LIKE FAMILY 10 MEMBER B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="227"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="228"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5074827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="262" mass="30291" checksum="643F9A7C62880A14" modified="2022-05-25" version="1">MDNCVAWKEEKVYLDLDLDYLERRVGDTIGDDNVDSGSKEEDSPADSLDRVKVIFLGAPGVGKSSIIRQFVWNEFFEDYRPTERRETFYPSVVHADRLYELKITDLPTIPYFPVSTHLEWTDFRYYGLRSATAYVLVFDLSNQDTFQYIRTLREQMYEARDMRGVPLLVVGNKQDKLSAVVASGARYRDIVNLVRKHWRCGYVECSARFNCRVVQVFRELMKSIQAAEGTTPSPTPTASQHQQQQLRSAHTSRDTSDKCFII</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2ENF8</accession>
    <name>A0A8J2ENF8_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS1602</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001116">
        <property type="protein sequence ID" value="CAG5075448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2ENF8"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5075448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="87" mass="9499" checksum="C48486E0BA13C5A4" modified="2022-05-25" version="1">MLAVAVFIAAVKAAVSSVLRPISRKTPPRFVCLIDFMSTPVSIGLTLVLISLRRSAYVRPSAGWTSTAFVLVFFILGFLEPPLLGWF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2ENR4</accession>
    <name>A0A8J2ENR4_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS1875</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001116">
        <property type="protein sequence ID" value="CAG5075815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2ENR4"/>
    <dbReference type="OrthoDB" id="7706737at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="129"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="137"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="170"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5075815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="218" mass="24906" checksum="AAE1AC42B0E434A7" modified="2022-05-25" version="1">MWKYAEVESISSKQKFIVETKHIKNFDKYSQATKSKLYSVEQSGKYVRCLILKTANSMEDIKNPCSRSRRPKPNLSSLEEKSDDSDESIDLTAVKRKRKAKGQNDAKSKKVTNEDILKTYAKLRNFKSDNFRQVIPETDDEVEDDGSSNDAVDEDESNNSGLEDTLEQEDIYHENETGVRNENDENTSDEDLFETQLSNGLAYPGSHEVEQDNFINLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2ENT8</accession>
    <name>A0A8J2ENT8_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similar to Ccdc186: Coiled-coil domain-containing protein 186 (Mus musculus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS1935</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001116">
        <property type="protein sequence ID" value="CAG5075934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2ENT8"/>
    <dbReference type="OrthoDB" id="5583482at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099518">
        <property type="term" value="P:vesicle cytoskeletal trafficking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038830">
        <property type="entry name" value="CCDC186"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18911:SF5">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 186"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18911">
        <property type="entry name" value="CTCL TUMOR ANTIGEN HD-CL-01"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="205"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="433"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="513"/>
            <end position="674"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5075934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="780" mass="90339" checksum="27E2697583E2C259" modified="2022-05-25" version="1">MEEMCSINSNNKINFVSTPELDSINNHNDSDDKITLTDSINNESTKTFQENQTSNLDLDKVEILSEIDNLDVENKLPNEGEQRSESLQLKHLEINDSLDPHKSQLLVTKFAHSNLIQSSVPLINKSRNLLNFITEKSTNIMEKALLPQYLQQKELAQKLGNCEEGESADQKTGREDDFLEGGKEEVDTVEVNGGEIDCGRLLEELRKVSRDKIMLEERIKELEINQVSKEPVSPSIDNRDATISRLTSELRSALSQKDALLHQYSSANKERESMVMKYAISEKQRLDLQRNLEQSHSRLKQLTSDNEVVTSKLKTAFNERSRVTQMLDVKCRELIDAQKELEKLREDLDLREVKLKWTQAKLKSELVSHKETSEKLEKASLKINELKDECENVRRESCESIKKFQQSEENKAVTLDHQLKEQHARLILERHVVEDKEAERLQLLKEIETLNHRQQVLIEENNALTLRNNDLDAIYEELKRNFDELSVVSEERLKAINDLTVKAEALEGTRLELMARNQELLATESELQRLQAANKELQVDMDCCVQRENQMLEFTQKLTDKNVRLQSEFTITESRMKELEKELVPFREQVKELKARIKEITEELRDEKKKRVDECELLARHLAEQTKMAENLKQLLEDSKGENLVLKRKHQMTIKELTREVGQLKKKLEGTSSAVEGAVQTRTPSVLSLNEEADKEAGVIYNELDKQALVDRVIKLQRVNVKRAEKLDFLEEHTRVLVVELQKKTKIIQNYVLSESFDAMGSNERDKYKVGLKVGWERFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2GZ96</accession>
    <name>A0A8J2GZ96_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS224</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001090">
        <property type="protein sequence ID" value="CAG5073093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2GZ96"/>
    <dbReference type="OrthoDB" id="7554092at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5073093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="239" mass="26946" checksum="3BAE77900E3A5930" modified="2022-05-25" version="1">MRTYANLLKEIKAKVSPVETGVDIRSIKKTKHGGVLLEMARKTEESKAFTDAVKAATANIGTVKTLTPTTTIEILDLDEISTESEVCKALKREFTDSLEVKRVNLTKPTPRGNLNRCALAQNLLRQRVFEDKTDVCFICEQYLNIEGKTWFADETGTAAIWIVNTKNVTRKWNAKRLDLEAFKASLARSWSILQNNPTSDTCSETEKAVLNTMKEIAAACDASMPRLKNQSFHRPAYWW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H065</accession>
    <name>A0A8J2H065_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">type I protein arginine methyltransferase</fullName>
            <ecNumber evidence="2">2.1.1.319</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">HICCMSTLAB_LOCUS1612</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-arginyl-[protein] + 2 S-adenosyl-L-methionine = N(omega),N(omega)-dimethyl-L-arginyl-[protein] + 2 S-adenosyl-L-homocysteine + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:48096"/>
            <dbReference type="Rhea" id="RHEA-COMP:10532"/>
            <dbReference type="Rhea" id="RHEA-COMP:11991"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29965"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61897"/>
            <dbReference type="EC" id="2.1.1.319"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:48097"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-arginyl-[protein] + S-adenosyl-L-methionine = N(omega)-methyl-L-arginyl-[protein] + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:48100"/>
            <dbReference type="Rhea" id="RHEA-COMP:10532"/>
            <dbReference type="Rhea" id="RHEA-COMP:11990"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29965"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:65280"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:48101"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.319" evidence="2"/>
    <dbReference type="EMBL" id="CAJNRD030001116">
        <property type="protein sequence ID" value="CAG5075458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H065"/>
    <dbReference type="OrthoDB" id="7848332at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042054">
        <property type="term" value="F:histone methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035242">
        <property type="term" value="F:protein-arginine omega-N asymmetric methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.160.11:FF:000001">
        <property type="entry name" value="Blast:Protein arginine N-methyltransferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000003">
        <property type="entry name" value="Blast:Protein arginine N-methyltransferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.160.11">
        <property type="entry name" value="Hnrnp arginine n-methyltransferase1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049482">
        <property type="entry name" value="ANM3-like_C2H2_Zf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025799">
        <property type="entry name" value="Arg_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055135">
        <property type="entry name" value="PRMT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11006">
        <property type="entry name" value="PROTEIN ARGININE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11006:SF53">
        <property type="entry name" value="PROTEIN ARGININE N-METHYLTRANSFERASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21137">
        <property type="entry name" value="ANM3_C2H2_Zf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06325">
        <property type="entry name" value="PrmA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22528">
        <property type="entry name" value="PRMT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51678">
        <property type="entry name" value="SAM_MT_PRMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 12" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="28"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="163"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CAG5075458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="534" mass="61200" checksum="D4B9FB4DA236E284" modified="2022-05-25" version="1">MNIDTSDSDGSGDDWDELKEDELINISCLFCKDEFQGYNDALNHLKLQHLFDMPKLIKDYQLDDYSFRKFINFVRQHKLTPNDIGSIKCDTWENDKYLTPIIPDDAWLMFDIEELDDNLIANHRSIEVIEEVNEPHTPTNNERLNSYPVNAENGCVTLSEQHFVELQKTIKELKLQLKQREAAYFCAKEQIEEMQKKVQNLIIEDDVDIPKRLLNSTGVLNDDGYFNTYSHFAIHHEMLTDTVRTESYRDALLTNSHLFNNCTMLDVGCGTGILSMFAAKSGCKKIISVDQSDVIYHAMDIVRENNLNDVIELKKGRLEDIDLGIDKVDAIVSEWMGYFLLFEGMLDTVIYARDHHLKAGGKLLPNRCTLSVVGSGDTKRYIDLVDYWSNVYGFKMSCMKAKVVKEPSIEISNVKDIVTNVSLIQNFDLYTVDTNCVNFTAPFEFNIKKTGSLTAIIGYFDVFFDLDNPVKFSTGPHSQPTHWKQTVFSLSEPISITEGEIINGKLICQRHPKDNRALIITIVIKNHSQVYYLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H0D7</accession>
    <name>A0A8J2H0D7_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Similar to sqd: RNA-binding protein squid (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HICCMSTLAB_LOCUS1930</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001116">
        <property type="protein sequence ID" value="CAG5075924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H0D7"/>
    <dbReference type="OrthoDB" id="1875751at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12325">
        <property type="entry name" value="RRM1_hnRNPA_hnRNPD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48032:SF6">
        <property type="entry name" value="RNA-BINDING (RRM_RBD_RNP MOTIFS) FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48032">
        <property type="entry name" value="RNA-BINDING PROTEIN MUSASHI HOMOLOG RBP6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="62"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="142"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="321"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="15"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="322"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="334"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAG5075924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="362" mass="39165" checksum="0BABCE5112063B3A" modified="2022-05-25" version="1">MADQDNKDFTEDITDQSYDQNGDAPQNETGNGGDAGDANENGQDSQDDKSGSDGNQESLNDRKLFVGGLSWETNDKELRDHFGSYGDIESINVKTDPNTGRSRGFAFIVFSKAESLDKIMAAGDHVINNKKVDPKKAKARHGKIFVGGLSTELSDDDIRSFFDKFGKIVEVEMPFDKTKSQRKGFCFITFESEQVVNELLKTPKQTINGMRGGAAAGRGAARGGRGGRGRGFGGQGWSQGGYGAGGYGGGYGQGGYGGGYDGYGSYDYYGGGYGGYGGYDYTGYDGYGYGGSYDSGYNGGRGGARGKGLQTYSKIHNSLNHHSIKSSRHQQSRQLPQNNYNNQQQDSQHQKNHQQTNVSYMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H0F9</accession>
    <name>A0A8J2H0F9_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS2037</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001116">
        <property type="protein sequence ID" value="CAG5076056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H0F9"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5076056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="91" mass="10124" checksum="C995550175090CC9" modified="2022-05-25" version="1">MARLCVGCTKTFSYYPWQSFERHFTLSYLERRASTESSGSASRDYHAKIPGPGGGYQPDSFGPCQDSRPPVFVWPGAKTSAETSRTQADYC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H1M1</accession>
    <name>A0A8J2H1M1_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS678</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001114">
        <property type="protein sequence ID" value="CAG5073906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H1M1"/>
    <dbReference type="OrthoDB" id="7685730at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="117"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5073906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="345" mass="38931" checksum="E0A1AF0A3AFABF3F" modified="2022-05-25" version="1">MSDKSVKVFAVVEFDECIGDEKSVELIPMIWLAEDEMSCLWTPEDEGKNVQKLIEKKIAPGSDWQRFPVRVIRKAKSFEQGMRRLKRSFETPDVDSSEAEKRRNDDQVIVMSSQNFASELNTSSPMKHQKTASSGCKNKRKDNDGENACPPPKKPKIDLTCMNDLGLFLKSIIEKEGEKTRQFLSLAITERYRQELANARSTANNPNNSEAWKIIGDDMPFSELGKFVEFDQSLEKDEEKKSSLMAMFKMVTVGSTTKEHDVATIISKVIKKVIQLEYSATGKRSKGVGKKSFKDTETFKVMDKFLLAKYANSAGIISTITALSNFLSGAKDREGGRAHRDENRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H5C9</accession>
    <name>A0A8J2H5C9_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Similar to Lhcgr: Lutropin-choriogonadotropic hormone receptor (Mus musculus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">HICCMSTLAB_LOCUS1689</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001116">
        <property type="protein sequence ID" value="CAG5075535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H5C9"/>
    <dbReference type="OrthoDB" id="1883493at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008528">
        <property type="term" value="F:G protein-coupled peptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016500">
        <property type="term" value="F:protein-hormone receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007189">
        <property type="term" value="P:adenylate cyclase-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009755">
        <property type="term" value="P:hormone-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15136">
        <property type="entry name" value="7tmA_Glyco_hormone_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000156">
        <property type="entry name" value="Lutropin-choriogonadotropic hormone receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002131">
        <property type="entry name" value="Gphrmn_rcpt_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24372">
        <property type="entry name" value="GLYCOPROTEIN HORMONE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24372:SF82">
        <property type="entry name" value="RICKETS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00373">
        <property type="entry name" value="GLYCHORMONER"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00364">
        <property type="entry name" value="LRR_BAC"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="4" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="10 14" id="KW-0675">Receptor</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="11" id="KW-0807">Transducer</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="512"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="540"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="579"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="619"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="661"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="706"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="741"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="13">
        <location>
            <begin position="523"/>
            <end position="758"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CAG5075535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="1025" mass="116267" checksum="702ACD33364190AD" modified="2022-05-25" version="1">MTLMYKLFWINQIIVYSIFFGFLPIVFNSKIYNRNYEQRCTVTNNGKELNCQGIGLQSVEEAFESHISSSTISNITKINFNHNSITYIPATVLNSMTSIEIIFLRRNQIKGIHHDGFKNLPNLKVLELDDNCLTEIPKVIKHLHNLEDLSLSNNKIEQLDSNAFSGNPNITSIDLRGNPIKKIHLRTFQNHVKLRKLILSNNKELMHFPSLNGTQSLEILRLDRASLTSLSDHFCVQSPNLKSLNLESNFLTTIPHLKDCRNLRVLNLVNNKITEITGNKFTTLNLLHDLLLSRNEIKTIPSNAFNGLKNLQVLDLQSNEIEYIDPDAFSSCQNLKDLNLGNNVFPTLPITGLQNLRHLKTFNNPKLEEFPSTESFPSIKTMVLSYAYHCCAFLSMNKNELIERIPIRESIIFPTDNSLDASLWNSSLLNVWIQLQKLSRKNNSGINNYLNNLAVNFTEHNGTFSSDDNFLDAQNEMLATPTGETYSVKCLPRPGPFLPCRDLFDWWTLRCGVWIVFLLAMLGNGTVVFVIVFSRSKMDVPRFLVCNLAAADFFMGIYLGEFRKYAIPWQMSVGCQLAGFLGVLSSELSVYTLSVITLERNYAITHAIHLNKRLSLKNAGYIMIIGWIFSLSMAILPLLGVSDYRKFAICLPFEIDGTASLSYLVFLMLINGVAFLILMGCYLRMYCAIRGSQAWNSNDSRIAKRMALLVFTDFLCWSPIAFFSLTAMFGLRLVSLEQAKVFAVFILPFNSCCNPFLYAIMTKQFKKDCVLICKAIEESRVTRGIGRCRHSSNFSNRQTPFNTNSIVDRSSREHQTLCVCNSRHTIVNNSKRWCGLEIIWSCGKGKHQRRSRVDQYAYRIAEIQQKQHKRACSMSSSENFSSSRSDSWRQANHCSIPLRFIDSKKHGSLWLIARKSSHDSNLSSSRNDSSSSGITASTSTWKISRSSTYSDIGTPKLARPKPRLIRQSAVQEPDSLFSPSRLAVRLLATIPSAADTNEQLAINNDKKFEDNEGEVKIDEKSVCIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H5N5</accession>
    <name>A0A8J2H5N5_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS1266</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001116">
        <property type="protein sequence ID" value="CAG5075103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H5N5"/>
    <dbReference type="OrthoDB" id="6233064at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="145"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="57"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="145"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5075103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="318" mass="35764" checksum="87D3875589AE50A1" modified="2022-05-25" version="1">MTILSALSLSVDKNEKKNKRRCVLSHGKKGGEWRKLLYGIKLVTLCRRRHVCRSCGAPAPNSSSSSSSSSSSAAAAASSLPSPLPSPETLKLDCRLNHLQDKEDNYDVRLGCCYSRLRSHQLHDHHSHHHHRHHQGGYLDLDADNQSRQESSSSRHTASSDNRLLQDSSDDSLTRITGLRTTSTTIPTISSSKRDFTINYNNNTNINNNNNNNNNYNYNNNNIECGNVEINNSKQILQTRQRTRRETCRDTNRTVDTIHRRNGIPSYLATILLLSYALFGIAADNVSIDRADTNAELERRADETGLRQRREALQSVID</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H5R8</accession>
    <name>A0A8J2H5R8_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS1767</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001116">
        <property type="protein sequence ID" value="CAG5075613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H5R8"/>
    <dbReference type="OrthoDB" id="8173437at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5075613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="155" mass="17558" checksum="84EFA802644D8F57" modified="2022-05-25" version="1">MGWVALGRRAGGSSRLSPILSLSLASLVSSLLFTTLCVLTLALTFATFVRSEDIFEEGKSDKEILDNLLLSTRYDKRLLPPVQGTLRPPPHTRQDDYIPDHLDSPNDQPNQQPEHHLRHHRHQNHHTARHNHSSLLTSRRKGTSLNLMKKQSECC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H679</accession>
    <name>A0A8J2H679_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS2673</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001117">
        <property type="protein sequence ID" value="CAG5078206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H679"/>
    <dbReference type="OrthoDB" id="8197686at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012464">
        <property type="entry name" value="DUF1676"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21879">
        <property type="entry name" value="FI03362P-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21879:SF27">
        <property type="entry name" value="OSIRIS 10A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07898">
        <property type="entry name" value="DUF1676"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="167"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="199"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5078206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="310" mass="35136" checksum="A2121917FA211845" modified="2022-05-25" version="1">MEPKDKNISENSDTNSNPNPNFGSKNNRNHDNVEGSFSRVFTQCVDKKVHGTLECFNEGSFSVLRSMNDEDRLDFGDVRLDKSESEARDLMDLDYDPKDFSIVVKAAARMMERRNLKWDLGYFYPGLMMKVGPALNSNGMLEFALDERVAGHSNRQLGPGRMIMRSVVVPFLLGLKFSLSSLIPLVFGVLVVVTKKALLLTKVALIISGLLGWNAFVSSPNIAGLSHGAPSGFQSNYNNFNGFQHHFQHGYDHNTINEHHYPYRPYRNFVKDVPGYNHHVIKEVVEVYDPESDARRDNTRSGKNFLWSRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H6A8</accession>
    <name>A0A8J2H6A8_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS2689</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001117">
        <property type="protein sequence ID" value="CAG5078254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H6A8"/>
    <dbReference type="OrthoDB" id="7694116at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5078254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="150" mass="17496" checksum="A63F00F559021DFD" modified="2022-05-25" version="1">MSAKLLRSLFIEESPHIKCSDRLAAKLNNVTFKIPNFSTTLFEHLFIVAVIRLRRELPTKMKNSLSLETFKIKAFNFFLMLIKTIYFTCNRIPSSKISNLKRFDGVLVLEMYESSVTFSFNTRFWLLDICPRCCGTRLLHLTSYRAVVNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H6S0</accession>
    <name>A0A8J2H6S0_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS2889</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001117">
        <property type="protein sequence ID" value="CAG5078956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H6S0"/>
    <dbReference type="OrthoDB" id="7666905at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032062">
        <property type="entry name" value="DUF4803"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47890">
        <property type="entry name" value="LD24308P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47890:SF1">
        <property type="entry name" value="LD24308P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16061">
        <property type="entry name" value="DUF4803"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035288409" evidence="1">
        <location>
            <begin position="20"/>
            <end position="624"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5078956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="624" mass="72071" checksum="986EC5B5164FDFC5" modified="2022-05-25" version="1">MIAKVTVTITFIFFAICGAEPLEKSDIYDTTAVNRFFQSLMEKVERNTYQLEIKTDDDTKSRILKDILSDAVEALEVLNTISSDILEEYWFPHFRRLLKNLQEAEIMEGEVRRSFMPLVSSMQETWGTIDAHAESLISLHKSNDSDHLAGLCPLLFGVTRFLEIDHRAQSIAKIYQNFIDNVLQEFSLESSWKSCGQKSSLREGLFKFFRKVMTSYLKEFVLYWFVNVANARCMDRNSPGMLGELFGIYVNKFDKNLRITRNTIHFYQFNNREWYYELEKMIQTIIVNEKDMSIPESCSHNCDLSPLKYPINHSDCKEFRDCHLIKGRLEVCKTYENYNSRRYQWFKDSEGVVYGNQSQQCYQKESLGSYYDGWKVRDCDYCMCTCIKKQESGYHVVTAISFREQVSNTADNMVVVGVRFVRQGYMIHVQIKEGRLGLTRFNKYDPWKPVEDIGYDESTQKFFLINGNTPLQLGLDYWHPKTMNLDDLVAPLGYAVTGVRFGLAEGSIELQIRVSPMDFINGRILDDDDWTYWISPEHKDQRTELILSEPDLPTKSTKNLVDSSKGQFVEFQRSDLKKDAGQSTVPFFDAMEVEGAPGFPVGGVGIVHRGKKGFGGHLPTILTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H735</accession>
    <name>A0A8J2H735_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="3">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">HICCMSTLAB_LOCUS3086</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 17">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="3"/>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5080718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H735"/>
    <dbReference type="OrthoDB" id="10063692at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.40:FF:000005">
        <property type="entry name" value="Ataxin 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.10:FF:000023">
        <property type="entry name" value="Ataxin 3 variant ref"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.10">
        <property type="entry name" value="S15/NS1, RNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033865">
        <property type="entry name" value="Ataxin-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006155">
        <property type="entry name" value="Josephin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003903">
        <property type="entry name" value="UIM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14159">
        <property type="entry name" value="ATAXIN-3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14159:SF0">
        <property type="entry name" value="ATAXIN-3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02099">
        <property type="entry name" value="Josephin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01233">
        <property type="entry name" value="JOSEPHIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01246">
        <property type="entry name" value="Josephin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00726">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50957">
        <property type="entry name" value="JOSEPHIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50330">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Josephin" evidence="14">
        <location>
            <begin position="1"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="187"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="227"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="249"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="286"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="active site" evidence="12">
        <location>
            <position position="14"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="11">
        <location>
            <position position="14"/>
        </location>
    </feature>
    <feature type="active site" evidence="12">
        <location>
            <position position="121"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="11">
        <location>
            <position position="121"/>
        </location>
    </feature>
    <feature type="active site" evidence="11 12">
        <location>
            <position position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR633865-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CAG5080718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="351" mass="39565" checksum="48E575CDF91CAEAF" modified="2022-05-25" version="1">MESIFHEKQEGYLCAQHCLNALLQGSYFNAVDLANLAQQMDEEERLRMAESGLDSDDYRRFMQQPSENMDDSGYFSVQVISSALKVWSLELIPYNSTEPTALIAQNDPSRMQAYICNYKGHWYTIRKLGNQWFNLNSLLNSPQLLSDTFLSMFIAQLIQEGYSIFIVVGELPECIADAVLLKNPVTTASKSKPDQTKPESSGYRLGTAEEDERKKIQQAVADIERVKVPGSSLAQSSSGGKEKIIPIVLEDDDDDDDDDEYDDKANLEKALQLSLQDEEADKSLKLRLNSNSNSKPSPEEEEEDDELRKALQLSLECVTAPTTPDPDDLRWRRLAFLNNLSRSGNESKLNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H773</accession>
    <name>A0A8J2H773_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Similar to OtopLc: Proton channel OtopLc (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">HICCMSTLAB_LOCUS3232</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the otopetrin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5081261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H773"/>
    <dbReference type="OrthoDB" id="7614474at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015252">
        <property type="term" value="F:proton channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004878">
        <property type="entry name" value="Otopetrin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21522">
        <property type="entry name" value="PROTON CHANNEL OTOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21522:SF61">
        <property type="entry name" value="PROTON CHANNEL OTOPLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="10" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="199"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="241"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="34"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="102"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="72"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="37"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CAG5081261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="280" mass="30647" checksum="3A7362DC61CCA85C" modified="2022-05-25" version="1">MGESSPDLSLRLRRGSSDSRDSFYMDFAQGIDSDIEEVTRPRENHIDENHLGEEEIEENFPPLDDICTTIPEEASEELREEEEEEAAAAAAAAAALEAARETSDSSVISGNGKMQKRAQNQNDWPGLPAALPSPASPSAVIVSPETLSRNSSTSPSRTHTVGQFALALPCPPRPIPAVCYPAPTFIEVADDANNKHLGAYALATTLSALYGKLLVVMGIAFPMSEVISSYIPPSFYEAFYLYLYFGSMLFLLCMHSLMLIDGKPKQSNYQIVLFYSLIER</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H794</accession>
    <name>A0A8J2H794_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">HSP90.1_Cc</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HICCMSTLAB_LOCUS3326</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the heat shock protein 90 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5081580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H794"/>
    <dbReference type="OrthoDB" id="5426351at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.80:FF:000001">
        <property type="entry name" value="Heat shock protein 90 alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11260:FF:000001">
        <property type="entry name" value="Heat shock protein 90 alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.790">
        <property type="entry name" value="Heat shock protein 90, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037196">
        <property type="entry name" value="HSP90_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001404">
        <property type="entry name" value="Hsp90_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11528">
        <property type="entry name" value="HEAT SHOCK PROTEIN 90 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00183">
        <property type="entry name" value="HSP90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110942">
        <property type="entry name" value="HSP90 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0346">Stress response</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG5081580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="408" mass="48063" checksum="B97F9C73F824375A" modified="2022-05-25" version="1">MKTTSPRLKTLVRTRRKTKKIKKTIKEKYTEDEELNKTKPLWTRNPDDITQEEYGEFYKSLTNDWEDHLAVKHFSVEGQLEFRALLFAPRRAPFDLFENKKRKNNIKLYVRRVFIMDNCEEIIPDYLNFMRGIVDSEDLPLNISREMLQQNKILKVIRKNLVKKCMELFDELAEDAENYKKFYEQFSKNLKLGIHEDSTNRKKLSELLRFHTSSTGEEMCALKDYVGRMKEVQKHIYYITGESREQVAHSSFVERVLKAGFEVLYMTEPIDEYVVQQLKEFDGKQLVSVTKEGLELPLSDEEKKKMEEDKTKFEEDHPIMENLRQKIEADKHDKSVKDLVMLLFETSLMSSGFALEDPQIHAARIYRMIKLGLGLDDDDAPMEEITIEETPAIAEVNDDEASRMEEVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H7F4</accession>
    <name>A0A8J2H7F4_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific protein-tyrosine kinase</fullName>
            <ecNumber evidence="1">2.7.10.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">HICCMSTLAB_LOCUS3187</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.10.2"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.10.2" evidence="1"/>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5081076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="98077at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004715">
        <property type="term" value="F:non-membrane spanning protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007154">
        <property type="term" value="P:cell communication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048468">
        <property type="term" value="P:cell development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002009">
        <property type="term" value="P:morphogenesis of an epithelium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051129">
        <property type="term" value="P:negative regulation of cellular component organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0023052">
        <property type="term" value="P:signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05052">
        <property type="entry name" value="PTKc_Abl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09935">
        <property type="entry name" value="SH2_ABL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11850">
        <property type="entry name" value="SH3_Abl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000010">
        <property type="entry name" value="Tyrosine-protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000037">
        <property type="entry name" value="Tyrosine-protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.505.10:FF:000004">
        <property type="entry name" value="Tyrosine-protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000542">
        <property type="entry name" value="Tyrosine-protein kinase Abl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.330">
        <property type="entry name" value="Nucleotidyltransferases domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.10">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035837">
        <property type="entry name" value="ABL_SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015015">
        <property type="entry name" value="F-actin-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050198">
        <property type="entry name" value="Non-receptor_tyrosine_kinases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000980">
        <property type="entry name" value="SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24418">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08919">
        <property type="entry name" value="F_actin_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00017">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00401">
        <property type="entry name" value="SH2DOMAIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00808">
        <property type="entry name" value="FABD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00252">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55550">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50001">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 17" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0727">SH2 domain</keyword>
    <keyword evidence="2 11" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="domain" description="SH3" evidence="15">
        <location>
            <begin position="107"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="SH2" evidence="14">
        <location>
            <begin position="174"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="16">
        <location>
            <begin position="289"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="52"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="619"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="698"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="793"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="833"/>
            <end position="928"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="943"/>
            <end position="1064"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1147"/>
            <end position="1188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1210"/>
            <end position="1333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1349"/>
            <end position="1371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="64"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="793"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="809"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="833"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="888"/>
            <end position="906"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="13">
        <location>
            <begin position="913"/>
            <end position="928"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="974"/>
            <end position="988"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1009"/>
            <end position="1029"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="13">
        <location>
            <begin position="1035"/>
            <end position="1048"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1150"/>
            <end position="1159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1178"/>
            <end position="1187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1210"/>
            <end position="1221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1256"/>
            <end position="1272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1306"/>
            <end position="1315"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="328"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00051245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CAG5081076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="1479" mass="163974" checksum="D2307E558992D96A" modified="2022-05-25" version="1">MGAQQTKDRVIPTGSTVRQTRKQPRNPKESRLIGSNIFTEHSEALLQSRPLPHIPALPEGDPPTGSSVQSLSQQSNFSAHSNVTGGSLLEAANRWTSKENLLAQEEDDPQLFVALYDFQAGGENQLSLKKGEQVRILSYNKSGEWCEAHSSTGQVGWVPSNYVTPVNSLEKHSWYHGRIARNAAEYLLSSGINGSFLVRESESSPGQRSISLRYEGRVYHYRINEDSDGKMFVTTESKFNTLAELVHHHSMLADGLITQLLYPAPKHNKPTVFPLSPEPDEWEINRTDIVMRHKLGGGQYGDVYEAVWKRYNMTVAVKTLKEDTMALKDFLEEAAIMKEMKHRNLVQLLGVCTREPPFYIITEFMSKGNLLDYLRNESKHQINAVVLMHMATQIASGMSYLESRNFIHRDLAARNCLVGENHLVKVADFGLARLMRDDTYTAHAGAKFPIKWTAPEGLAYNKFSTKSDVWAFGILLWEIATYGMSPYPGVDLTDVYHMLEKGYRMECPPGCPPKVYELMRQCWQWSAIERPTFKEIHHSLENMFQESSITEEVEKQLQGGCDTPMFSYNHKKSQTGSTGNIHGLVLVSDQLSNTGLTQDAGSNVTKLSTFMGGLTNKANSNMVQMRRSTNKRGKQAPAPPKRTSLLSSCSSFRDSAYQEQDQHNIDSVGASNLDDGTDLNGIDNISKGITRDLVTMATQSIPPGGCDLEDDGDGSQGTESNFLPQPPASPEPILNICNQKQIKTRQYSSKEVLSQKLVHVGALEVQNVKRAINRYGTLPKGARIGAYLESLRQSGMPSAHESPSSIDLHQQQQQHPQHQQPHEAINIIETSQHRSLSPRQNNLRNQPQMTRSNSSSGVVNTYQPPNSPRSRMSSRKNNNDNIGLRTFRNPNTSTFRTASPSRSVQPTLADLEFPPPPLDLPPPPCDPNIDPPDFSTFNPPGDVPYKPSGSPVCVRKSKIDRKSKEEIIEEDDKNNDLRTAEPSVKEASSRFGVNLRRRETTSVGGSESNKIEDKKNIFRGKESMEKKDGVLSPPTEAPPPPPPLPPPSNNDSDDGFNLKPGMKEMLELKLINEIKQNADLKQSGTSRKSNHLDPASQLLSELCANFNIDQSNTINTVNKSPIQGEYASLNCLNDSPYDQTNNQLSNVEKSVSHNKDTKVSPDTLNPGSVGFKLKKVDKKSNLQKDDNNDGQIIDFKARLRKVEKDNIDKHDKDDKIKKNDDVGADMSENDDNDDKRKSTGSISSLKRLWENKESSWENQPLSPKLSTRSINKQDVGDPGEESPEDHSGASTRSSITSKSDSRISHPGNSTTSGSGDNIEKPLVPAKPGSKSIGSSGKYYGSSIYATPNCDKQEEDSVSGGVGKQQESKGAKHDVLELSNAIEGSITNLKGTPVIVMASWLQLSDKVGLLHGLLQEVNSTEVAGAPSHARFQFRDLLSRLELQARQLRAAGTRNITENTRLLSDVHNTIKDVTNMIQRYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H7P0</accession>
    <name>A0A8J2H7P0_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="12">ATP-binding cassette transporter subfamily G member 7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HICCMSTLAB_LOCUS3582</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5082509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H7P0"/>
    <dbReference type="OrthoDB" id="66620at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03213">
        <property type="entry name" value="ABCG_EPDR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001077">
        <property type="entry name" value="Uncharacterized protein, isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043926">
        <property type="entry name" value="ABCG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050352">
        <property type="entry name" value="ABCG_transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48041">
        <property type="entry name" value="ABC TRANSPORTER G FAMILY MEMBER 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48041:SF26">
        <property type="entry name" value="FI22810P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19055">
        <property type="entry name" value="ABC2_membrane_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="390"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="420"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="461"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="499"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="529"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="613"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="53"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAG5082509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="639" mass="72349" checksum="0A0B17250ED7BCEC" modified="2022-05-25" version="1">MEVLMNEAANAPQTSPDRTDSQSRFDNSNPDNCFGNEESSLRKMTKEHQSADISFENLRYKVSIGFRRGTKEILHGINGRLPAKQLIAIMGPSGAGKSTLLDILSGYRLTGIQGTIKVNGDIRDLDTFRRTSAYITQDDRLQPLLTVLENMWVAADLKLGTNITKETKLSIIEEILLTLGLSDHLNTRSDRLSGGQKKRLSIALELVNDPTVMFLDEPTTGLDSSTCMQVVNLLKLLARQNRTIVCTIHQPSASLFQLFDHVLILAKGTCLYQGATGQLIPFLESVKLPCPMYHNPADYVIELACGEYGDDKIETLVNANQNGKNAQWFSNTIPAIEELKKDKANGIKRGYIFKKKLSLQATSQLHQLKVLLYRGCIKCKRDSTLTHLRIIVNIFTGIMLGTLFIQAGNEGSRVLENYNLLFAILMHHMMTSMMLTILTFPAELNILKKEHFNRWYTLKMFYLSITIIDIPVTFICCLLFSVIIYLMSGQLLEFQRFSMFFTISLMVVFVAQSFGLMIGAVFNVVNGTFAGPTLSVPMMMFAGFGVTLRDLPYYLKWGTYVSYLRYGLEGYIAAIYGQNRKDLECVEIYCHYKKPKTFLKDIAMRDDQFWNDVIALLGMLIITRTFAYYLLRWKLISSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H8Y5</accession>
    <name>A0A8J2H8Y5_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">phospholipase A2</fullName>
            <ecNumber evidence="3">3.1.1.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Phosphatidylcholine 2-acylhydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HICCMSTLAB_LOCUS4549</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.4" evidence="3"/>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5087580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H8Y5"/>
    <dbReference type="OrthoDB" id="10059604at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004623">
        <property type="term" value="F:phospholipase A2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050482">
        <property type="term" value="P:arachidonate secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006644">
        <property type="term" value="P:phospholipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.90.10">
        <property type="entry name" value="Phospholipase A2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016090">
        <property type="entry name" value="PLA2-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033113">
        <property type="entry name" value="PLA2_histidine"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036444">
        <property type="entry name" value="PLipase_A2_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12253">
        <property type="entry name" value="RH14732P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05826">
        <property type="entry name" value="Phospholip_A2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48619">
        <property type="entry name" value="Phospholipase A2, PLA2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00118">
        <property type="entry name" value="PA2_HIS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035272202" description="phospholipase A2" evidence="8">
        <location>
            <begin position="20"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="Phospholipase A2-like central" evidence="9">
        <location>
            <begin position="39"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="Phospholipase A2-like central" evidence="9">
        <location>
            <begin position="129"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF05826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAG5087580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="256" mass="29256" checksum="1A335834E1D26711" modified="2022-05-25" version="1" fragment="single">MQLFYLLTLLIFYLTIVSTVDIKKKVTYNTPGVTDRLLIFPGTKWCGPGNVAQDNYDLGSDRNVDTCCRDHDLCEPKIRSGETKYGIVNHGSTSILSCTCDEVFSNCLKAVNSWTSQIIENIYFRLLGRTKWCGPGDIASHIYDLGRFNDTDKCCRNHDLCQPIILSKQTRYGIENKGRIAMLSCSCDSAFYKCLKAVNSTVSRIIGNSYFNLLHRKCFYFDAKKETLEWMKVPDFSDNSIIKFVSKFTRNPFKKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H9S5</accession>
    <name>A0A8J2H9S5_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Similar to SERPINB8: Serpin B8 (Bos taurus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HICCMSTLAB_LOCUS4802</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the serpin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5088329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H9S5"/>
    <dbReference type="OrthoDB" id="671595at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004867">
        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.39.10">
        <property type="entry name" value="Alpha-1-antitrypsin, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.497.10">
        <property type="entry name" value="Antithrombin, subunit I, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023795">
        <property type="entry name" value="Serpin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023796">
        <property type="entry name" value="Serpin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000215">
        <property type="entry name" value="Serpin_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036186">
        <property type="entry name" value="Serpin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042178">
        <property type="entry name" value="Serpin_sf_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042185">
        <property type="entry name" value="Serpin_sf_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11461:SF211">
        <property type="entry name" value="GH10112P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11461">
        <property type="entry name" value="SERINE PROTEASE INHIBITOR, SERPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00079">
        <property type="entry name" value="Serpin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00093">
        <property type="entry name" value="SERPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56574">
        <property type="entry name" value="Serpins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00284">
        <property type="entry name" value="SERPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0646">Protease inhibitor</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0722">Serine protease inhibitor</keyword>
    <feature type="domain" description="Serpin" evidence="6">
        <location>
            <begin position="566"/>
            <end position="928"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="23"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="37"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="103"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="158"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="195"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="227"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="271"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="297"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="320"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="339"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="356"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="388"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="419"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="458"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="476"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="490"/>
            <end position="529"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAG5088329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="931" mass="103713" checksum="3689BFA1B55EA3F7" modified="2022-05-25" version="1">MKQFQKLGLCSGQNTTANKTEEISTTLSSAISTTVSPEKKDVTPKNDTTKTYDSEPSLDISESEDDEDSKITPGETTDKNVTPSGDRTTEKFTPAGTTIASKPSDRTPKEETTEPSKKEDAEKFTTKPSSEGIITLLDVTTPSPEKTSPKLLDSDPDGDYKNEDDQVFGKKTTADTSTTSEPLLYTKDGVTPAEETSKVPSEDDKKTTEPKSPEFSTKDSEDDRKTSGSTTGVTKSSHTTNKKDIKPSSGGHTDDDDASMTKTSDADATEDNTNINTATTPMDSYSKATPKTGSTDPIDKPTTEKVESPEKTSPKILDSEPGEDYKNEDDEVFSKKTTTDTSTTSYTKDGVTPAEETSKVPSEDDKKTTEPKSPESPTKDSEDDSKMYGSTTGVTESSRTTAKKNEPSGGHTDDDDNGSKTTPSPQNDNRSIPSTSAKPKMFESEPGDLNYTDEDNENPSKIDRDDKISKTPEALTTTTESVPSEETPEPENKVDDEKSKDLPVIESKVKANEVKPEASPKNPKPDLDNCLKVDKDTIDKLENITLQPLEKKTLKKIVKSINEFGLDLTEAVLRDNTTNYAIAPINFALLLLMAENGACKDTKKELDKTLHLSKEISKEELRPIKFLVDSLKDINETKLFLGDKIFLPQNVEISPEYRNLIQAAYQSDPLSVDYKKVNDVVEQINRWGANKTNNYVQRIISNTKNEVVSEDTSLLLAGVGYFQTNWVKSFDRLFNDHKLFYVGQNTYKSVCTMLQINQFYYYHMNYLPAEVIELPLKTNEDRELKMIVILPDEEKTLPDVLKNLHKFQYTDFRKHAKLEIVELSMPKFKIQSFIDLNNYSDKININKTIDDSNLCCMSKKAKISRILQKTVLKVNEGECAGPYYLCKYIIGDDNSCMIHKIKFTANRPFIFFIIKDDTIIFSGQIIDPSHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HA33</accession>
    <name>A0A8J2HA33_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PCI domain-containing protein 2 homolog</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">CSN12-like protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HICCMSTLAB_LOCUS4848</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CSN12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5088447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HA33"/>
    <dbReference type="OrthoDB" id="10252687at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070390">
        <property type="term" value="C:transcription export complex 2"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016973">
        <property type="term" value="P:poly(A)+ mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000973">
        <property type="term" value="P:post-transcriptional tethering of RNA polymerase II gene DNA at nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000146">
        <property type="entry name" value="PCI domain-containing protein 2 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045114">
        <property type="entry name" value="Csn12-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12732:SF0">
        <property type="entry name" value="PCI DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12732">
        <property type="entry name" value="UNCHARACTERIZED PROTEASOME COMPONENT REGION PCI-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00753">
        <property type="entry name" value="PAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="4">
        <location>
            <begin position="182"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00025771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00033214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00072421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAG5088447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="371" mass="42793" checksum="1673B3BF4CCE285B" modified="2022-05-25" version="1" fragment="single">DLLSLRHSHTSIPHLKTETAITKAMEHLSAPFDDLVMLHLKTLSSASKDDPRTTYNYQSSVVQSLTRILQLQKDDNWMLPVMNVVCLELRLLAIQAENTKSKNTKPGEVLEKCAECLMGCFRVCAADNRSSEEDTKRWGMLALVNQLLKVYFRINKLHLCKPLIRAIDSSIYKDHFPLAQRVTYKFFVGRNAMFDSNYRSADEYLTFAFEHCHKQSAKNKRLILTYLIPVKMLLGFMPKKSLLEKYNLMEFWDLVEAVKKGDLRKLETVMTEHESFFIGAGIYLIVEKLKLLAYRNLFKKVWLALNTHQIPVSNLLTALEIYGVEDVDMDETECLVANLIYEGKIKGYISHQHKKLVISKQNPFPRLSSII</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HA34</accession>
    <name>A0A8J2HA34_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Similar to atl: Atlastin (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">HICCMSTLAB_LOCUS3935</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5083810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HA34"/>
    <dbReference type="OrthoDB" id="7788754at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01851">
        <property type="entry name" value="GBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:003207">
        <property type="entry name" value="ATLastiN (Endoplasmic reticulum GTPase) related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:004169">
        <property type="entry name" value="Atlastin 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.420:FF:000001">
        <property type="entry name" value="Atlastin-1 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.420">
        <property type="entry name" value="AHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030386">
        <property type="entry name" value="G_GB1_RHD3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036543">
        <property type="entry name" value="Guanylate-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015894">
        <property type="entry name" value="Guanylate-bd_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10751">
        <property type="entry name" value="GUANYLATE BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02263">
        <property type="entry name" value="GBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48340">
        <property type="entry name" value="Interferon-induced guanylate-binding protein 1 (GBP1), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51715">
        <property type="entry name" value="G_GB1_RHD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="553"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="577"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="domain" description="GB1/RHD3-type G" evidence="13">
        <location>
            <begin position="163"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CAG5083810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="662" mass="74620" checksum="3A136E3145EACDEB" modified="2022-05-25" version="1">MMKVNLSPKRRQCTSSATYFSKWRVSDNTDVNKRKILVRIYILRNISSNNKNASRPISRRRLPDGFGMVARATKPPVTYRLDENVNRLSLSSHKISDDGGVDDKKTERIEELPSSVRSKPMDDVKKSEDGGRPVQVVLAHPDHTFELDEDALAEILLKDDIKDRSVVVVSVAGAFRKGKSFLLDFFLRYMNHQYGNNKSPSSWIGDDNEPLSGFSWRGGSERDTTGILMWSKVFPGTMPNGEKVAIILMDTQGAFDSQSTVRDCATVFALSTMLSSVQIFNLSQNIQEDDLQHLQLFTEYGRLALEKSGNTPFQKLEFLVRDWSYPYEAEYGAEGGQKILQRRLEISDRQHPELQSLRKHIKSCFSDISCFLMPHPGLKIATNPKFDGRLVEIESDFKHQLKELIPSLLSPENLVTKKINGQTVRARDLLEYFKSYIKIYKGDELPEPKSMLVATAEANNLSAVADAKDLYLQMMECVCGGTKPFLATAHLESEHQRCVDKALHLFSNKRKMGGDEFSQTYIEKLVKDMDDSFLQFKAHNESKNIFKAARTPAVFFAIAVTMYICSGVFGLVGLYTLANICNLIMGIGLLTLVLWSYIRYSGELREIGTQIDELASGIWENIMKPVYQRFVEKSVHVAVQHAANSANSTLANAAINGKYKVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HA95</accession>
    <name>A0A8J2HA95_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">chitinase</fullName>
            <ecNumber evidence="3">3.2.1.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">HICCMSTLAB_LOCUS3889</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1-&gt;4)-beta-linkages in chitin and chitodextrins.</text>
            <dbReference type="EC" id="3.2.1.14"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 18 family. Chitinase class II subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.14" evidence="3"/>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5083625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HA95"/>
    <dbReference type="OrthoDB" id="73875at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008843">
        <property type="term" value="F:endochitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02872">
        <property type="entry name" value="GH18_chitolectin_chitotriosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000007">
        <property type="entry name" value="Acidic mammalian chitinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.50.10:FF:000004">
        <property type="entry name" value="Chitinase 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.140.10">
        <property type="entry name" value="Chitin binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036508">
        <property type="entry name" value="Chitin-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011583">
        <property type="entry name" value="Chitinase_II/V-like_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029070">
        <property type="entry name" value="Chitinase_insertion_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001579">
        <property type="entry name" value="Glyco_hydro_18_chit_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050314">
        <property type="entry name" value="Glycosyl_Hydrlase_18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177">
        <property type="entry name" value="CHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177:SF360">
        <property type="entry name" value="CHITINASE 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00636">
        <property type="entry name" value="Glyco_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54556">
        <property type="entry name" value="Chitinase insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57625">
        <property type="entry name" value="Invertebrate chitin-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01095">
        <property type="entry name" value="GH18_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="7" id="KW-0146">Chitin degradation</keyword>
    <keyword evidence="4" id="KW-0147">Chitin-binding</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10 12" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 14" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035218773" description="chitinase" evidence="14">
        <location>
            <begin position="18"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="domain" description="GH18" evidence="15">
        <location>
            <begin position="20"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="388"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="388"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="13">
        <location>
            <begin position="447"/>
            <end position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CAG5083625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="510" mass="55802" checksum="53C079D78F1F3400" modified="2022-05-25" version="1">MRILAVIAAFYLAACTAEKGKIVCYWGSWSVYRPDSGKFEIENIDPYLCTHLIYTFVGLEGSDVKILDPWQDTPNDNGKDGFGRFNKLKLKNSALKTLIAIGGWNERSTEYSQMASDPGSRERFADNAVAFVKKWGFDGLDLDWEYPAQRGGSPSDVKNFVELVKVLGKKLHSQGLLLSAAVAAAESSASKSYDIAEISKYLDFINLMAYDFHGSWEPITGLNAPLHAASTDSYDAQGMNSEAAVKYWLSKGAPKKKLILGVPTYGRAFTLSNPRENGIGAASSGPGTAGPYTQEAGILGYNEICEMHKENGWKVNYDPERKAPWAHKENQWVGFDNKESIKAKAQFAKKMGLGGAMVWSIETDDFRGTCGEKYPLIKTLRVVLRGGQKNTKGTSARATVPNGSTRTTVSGDFTRTTVPNGSTETTVPETNVPGTENTEDDTWTPENGPPMTPSPVPSGQCKELGVVKDPKSCGFIKCALNNRGGYYEYPMPCPATLCFDPELKVCNWKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HAX9</accession>
    <name>A0A8J2HAX9_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Similar to NLE1: Notchless protein homolog 1 (Homo sapiens)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HICCMSTLAB_LOCUS5809</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5090943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HAX9"/>
    <dbReference type="OrthoDB" id="10267436at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007219">
        <property type="term" value="P:Notch signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012972">
        <property type="entry name" value="NLE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848:SF0">
        <property type="entry name" value="NOTCHLESS PROTEIN HOMOLOG 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08154">
        <property type="entry name" value="NLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 5" id="KW-0853">WD repeat</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="583"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="613"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="domain" description="NLE" evidence="8">
        <location>
            <begin position="19"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="110"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="152"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="195"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="242"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="332"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="374"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="416"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="659"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="698"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="663"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="737"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAG5090943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="737" mass="82050" checksum="6113A6C6080B3813" modified="2022-05-25" version="1" fragment="single">MNKRKSEEMEESDGTIHTVLARFKSEKGEILPETFNLPGGTTAKQLEGICNSLLQQEEPVPISFFINDVEVVGSLQDNLKGNDCEQVIDIVYQPQAVFKVRAVTRCTGSIEGHREAVISVAFSPNGESLASGSGDTTVRFWDIHTQTPLYTCEGHKHWVLCISWSPCGSKLASACKNGVIMLWDPETGKQIGKTMKGHKQWVTALSWEPYHRNPDCRYLVSSSKDSDLRIWDTKLGQTTRVLAGHTKSVTCVRWGGRGLIYSGSQDRSIRVWRAEDGVLCRVLDGHAHWVNTLALNVDYALRTGHFEIVKNPNAPEDLQERALKRYQALARMTGHRQLVNDVKFSPDGRLIASASFDKSIKLWEAVTGKFIKNLHGHIQAVFSIAWSADSRLLVSGSSDSTLKVWDVKAQSLAQDLPGHADQVYAVDWSPDAMRVASGGKDKVPRDWWWVQKISRCNSSYFCIFFAIFGTIIEDALSSSRRTGNNSMVSPNRLHGNWTNTRSCEGPLNRSAVGILYQPRDRENSNSVHESTRHHGHQAHGIANNVTNNTHVRRVLPNDPAINRGIIEISEISSAELAGYRLRCGVWITFILATGFVSIAKFYFNHRPDKGLDVLIFCGLLVALMISGCFYTTLFRRNRNDHHYHVPEISIATVATEAANEANHQQPGGDNNSLPMNSLATQHPVDQHQQQLISSSMLFPSTPSLSSPSPPPYHIAILIPPNSQYDEAPPPSYEKATR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HC83</accession>
    <name>A0A8J2HC83_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Similar to ANK2: Ankyrin-2 (Homo sapiens)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HICCMSTLAB_LOCUS6619</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5093143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HC83"/>
    <dbReference type="OrthoDB" id="419189at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051165">
        <property type="entry name" value="Multifunctional_ANK_Repeat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24123">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24123:SF33">
        <property type="entry name" value="PROTEIN HOS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035292482" evidence="5">
        <location>
            <begin position="23"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="34"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="71"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="237"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAG5093143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="601" mass="69230" checksum="8A4AEB478B9988B4" modified="2022-05-25" version="1">MVKITILVVVFITIELLIENGAILDAVCSGPEKVSQTPLYQAALMNHVGCAKTLLLHGAKLSLGSEGICEPLQIAVFKGHLEMVALLLDHGANVNTRFTNNFFELFKYALLPEVWKDQDLPLLHFAILMKSKKMAAFLFIRGADVNMETRGGNTTLLQAIKANNFEMARIRQSAIYIYDIKIKKKIILKILNKYAPEITIKVTGNSNSWITKELKYKCHERDSLYKRAKRTKNQDLLALYKDMRKKLKLELNNARENYLKSQLTTVSPGKTIWNKLKRLGLIKTKQTSPLNYFDASLLNEHYANIVRKHPPCDINFVNSLSSLYHKKVECSFKWHQIDIVDVTKALHLTFQKTKGKSPDGLNLSWLRSNSKLKSLNIDSLPPIIINNVPLPYVSQTKCLGLSLNNDLLWKNYVSQTVRKVNAVLYTLKSRKNIYTTAIRKLLVTATILPLIDYCTVVLIDATADNNLKLQRALNSSIRFIYNLKRDEHITPYRRKLNWLSVKSRRLYYLITYYYKLLQTGKPSYLRELFVEDEARRSERLAIKTNNVNFELPNFSTNYLENSFVVTTIRLWQNLPAEIANASSLEVFKTKIYDYFLELDFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HC87</accession>
    <name>A0A8J2HC87_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Similar to LAC12: Laccase-12 (Arabidopsis thaliana)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HICCMSTLAB_LOCUS5343</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the multicopper oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5089706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HC87"/>
    <dbReference type="OrthoDB" id="2121828at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13858">
        <property type="entry name" value="CuRO_1_tcLCC2_insect_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13905">
        <property type="entry name" value="CuRO_3_tcLLC2_insect_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011707">
        <property type="entry name" value="Cu-oxidase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001117">
        <property type="entry name" value="Cu-oxidase_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011706">
        <property type="entry name" value="Cu-oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045087">
        <property type="entry name" value="Cu-oxidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709:SF394">
        <property type="entry name" value="FI03373P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709">
        <property type="entry name" value="MULTI-COPPER OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00394">
        <property type="entry name" value="Cu-oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07731">
        <property type="entry name" value="Cu-oxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07732">
        <property type="entry name" value="Cu-oxidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0186">Copper</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035243046" evidence="5">
        <location>
            <begin position="20"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="8">
        <location>
            <begin position="64"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="6">
        <location>
            <begin position="193"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="7">
        <location>
            <begin position="444"/>
            <end position="553"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF07732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAG5089706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="599" mass="67377" checksum="C0C60F44DF8AFED7" modified="2022-05-25" version="1">MMSLFVFNFLLLLSTLIAGEELHECKRQCVSGNSLKCQYNFVVTEYHKSNTICRNESDNCNESINSVLLINGKTPGPAIEVCLGDIIEVFVHNKLPSSEVSFHWHGISQQGYVHMDGVPMITQCPIMPFSSFRYDFKPEKNGTYFYHAHSISQQADGLYGSLIVSSPSDDQNLQRTLILSVKSYPIYPFSQSTPVAIALTINGQANNHELNVHKGFSYRLRLINAGIFCPMGFFIDNHPLVAYAVGNTLVKPTETMHVIIFPGERIDLILNANRPVSKYRVVVQGLQGCRNLIYETSLTYDSAESNIPLGPAKDKADDDDGDPVHYLDVPEEMQGHDCRSIEKNTLCSLDLETTSNVIINNDPPAIYYLPFDVNYYPSITDDMTDYTFNIYGYSFYPSYLTIDGNPKVTQINKMSFKYPSSPILSQPELVSEDLVCSIEERSIACRNNPEFCECLQVLQVPAKKTIEIVLIDEGFGGNRSHVYHTHGYTVSVIGYQSFGRAVTREEIVSLDQSNKLPRNLINPPKLDSFVVPNKGYVILSFYTDNIGYWLWESRGYATTHSPPMQFLLQVGNPENMPTIPIDFPTCGNHKGPDLIFEDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HCK8</accession>
    <name>A0A8J2HCK8_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS7311</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5093985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HCK8"/>
    <dbReference type="OrthoDB" id="7634922at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035309926" evidence="1">
        <location>
            <begin position="23"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5093985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="61" mass="6909" checksum="50F004B58AB6D049" modified="2022-05-25" version="1">MLLIKRICSSVVLVLAVNIARALLPDDFEEQQFTGDNLQQDCASRCPDLDFNQAKTKVHYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HCN5</accession>
    <name>A0A8J2HCN5_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Similar to PFDN2: Prefoldin subunit 2 (Homo sapiens)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HICCMSTLAB_LOCUS7094</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="4">Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Heterohexamer of two PFD-alpha type and four PFD-beta type subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the prefoldin subunit beta family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5093768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HCN5"/>
    <dbReference type="OrthoDB" id="29646at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016272">
        <property type="term" value="C:prefoldin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23163">
        <property type="entry name" value="Prefoldin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.370:FF:000002">
        <property type="entry name" value="Prefoldin subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027235">
        <property type="entry name" value="PFD2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002777">
        <property type="entry name" value="PFD_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009053">
        <property type="entry name" value="Prefoldin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13303">
        <property type="entry name" value="PREFOLDIN SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01920">
        <property type="entry name" value="Prefoldin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46579">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="128"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="86"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAG5093768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="149" mass="17035" checksum="24390574A35D4A4E" modified="2022-05-25" version="1">MASDKKPGKSLPKGSKSNEEILAGFQTLRNDQRMMATKLSEMEMELNEHKIVIDTLKNVDPKRKCYRMVGGILCEQVVGEVLPGLVTNKERLIKVIETLNEQLEKKGKEINDYKEKNNIRIRGLDELQQTEEESKEPKRNALVVNPIET</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HCS6</accession>
    <name>A0A8J2HCS6_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Adenosine deaminase</fullName>
            <ecNumber evidence="4">3.5.4.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">HICCMSTLAB_LOCUS7449</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>adenosine + H2O + H(+) = inosine + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:24408"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16335"/>
            <dbReference type="ChEBI" id="CHEBI:17596"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="EC" id="3.5.4.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. ADGF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.4" evidence="4"/>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5094918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HCS6"/>
    <dbReference type="OrthoDB" id="7202371at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004000">
        <property type="term" value="F:adenosine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006154">
        <property type="term" value="P:adenosine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046103">
        <property type="term" value="P:inosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01321">
        <property type="entry name" value="ADGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.140:FF:000017">
        <property type="entry name" value="Adenosine deaminase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001365">
        <property type="entry name" value="A_deaminase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013659">
        <property type="entry name" value="A_deaminase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006331">
        <property type="entry name" value="ADGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006330">
        <property type="entry name" value="Ado/ade_deaminase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01431">
        <property type="entry name" value="adm_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11409">
        <property type="entry name" value="ADENOSINE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11409:SF39">
        <property type="entry name" value="ADENOSINE DEAMINASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00962">
        <property type="entry name" value="A_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08451">
        <property type="entry name" value="A_deaminase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0964">Secreted</keyword>
    <keyword evidence="8 11" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035201525" description="Adenosine deaminase" evidence="11">
        <location>
            <begin position="21"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="domain" description="Adenosine/AMP deaminase N-terminal" evidence="13">
        <location>
            <begin position="24"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="Adenosine deaminase" evidence="12">
        <location>
            <begin position="195"/>
            <end position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF08451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CAG5094918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="501" mass="57999" checksum="AC48B58AE78C3322" modified="2022-05-25" version="1">MKGSCVVVNLLIQLIIAVIAVECYSHDYWSKRAALIIEEERISLGGDLSLDPKERLVNDLLLTFKRKEIDDGFRGKAKFLPAKNFIEVRNDIKESKLFNIIKMMPKGAVLHAHDTAIVSEEWLYNNVTFRDNLYICDKAENLQLRFFDSPTDDCDWQLLKELRKNETFAAEINSRIRKEFSMMTDNPDRMYPDVNSAWKKFMSIFILITPMLTYRPVYEDHFYQGLKELYKDNVLYLELRSTLPPLYELNGTQYSPIDVVGIYKKVTERFIKDHPDFIGVKIIFAPLRIMSTSQLDEYIDTTLEIKRKFPDFFAGFDLVGQEDTGNSLELYAEKLQRMTNEVGFFFHAGETNWYGSKTDRNLLDAVLLNTTRIGHGYAIVKHPEVLKIVKERKIAIEICPISNQVLGLVKDLRNHPANILFAGGFPVVVSNDDPGLWGSKALSYDFYEAFVGMMSRDADIRALKQLAINSIIYSSMSDNEKQNAYDVWTRKWYQFLSKINY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HCU0</accession>
    <name>A0A8J2HCU0_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phenoloxidase-activating factor 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Prophenoloxidase-activating factor II</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HICCMSTLAB_LOCUS6891</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5093517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HCU0"/>
    <dbReference type="OrthoDB" id="5949700at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000038">
        <property type="entry name" value="Serine protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24258:SF142">
        <property type="entry name" value="PEPTIDASE S1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24258">
        <property type="entry name" value="SERINE PROTEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035213045" description="Phenoloxidase-activating factor 2" evidence="7">
        <location>
            <begin position="16"/>
            <end position="1144"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="8">
        <location>
            <begin position="900"/>
            <end position="1144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="25"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="206"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="276"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="523"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="820"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="35"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="71"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="206"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="216"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="228"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="535"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="820"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="831"/>
            <end position="851"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00068096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00076468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAG5093517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="1144" mass="124874" checksum="676D0C581A33D653" modified="2022-05-25" version="1">MWFILLTGLLAQGLATQVSFQSSSSAASSSEQKTEWSWQEPTAAGNSPQDSFHPLSFSSGDTQPDLLSDNSQVGSSESAYSSESAVVENILQSSRQGRNIAGYDDLYSDPDVKTVLQAGNDTIARAFIKDKLCSLGLMNCDDSEGRRPFYSPHRDIHPQEVIYAQPVTIKPVGRPLPAIPVKKPFVYGPPKPVPIPSFGSGPPVYGPPSSGHYSGPRPPFSGPPPSFSGPYPSYKKPSINSGPRPIYEDTGLDGEYDFVPENNNEFIEKKQVIVQPSSGLQQHVHHHYHHTDGNKPSSVIGPSAIAGNGLTGNGYGHGSGTYGNSYNDFDEYKKAFKIKSPSSGNSLDPIAASGNSYANRYPVYEKPKRDSFFNGKEGGKVVNSGFTGSQFGASNFGSNNFGTNGFGAGNNGFNNNLGASNGLNNNFGTNNFGAGNNGFNNNLGGSNGFNNNFGSNSFNNGFGSNNYDDCVCVPYDQCAAIDQAGRKDDLFLAIDPRNIGKNIDAETEDIVVTDANGTMSVIRVPKEVNATEQVQHTKEQKNSSDKKVDDADKNKSGEEIKRSKREAKAQPKNDDTQGRLLGNIDKSKLNLRPTWGVSFGLPQGGNYPVNSYGGNPLSNPYPGYGGGGNGLDLGLLSVNPLVSVQVSKDEYGEKVVKPFVNLHVTPNHGLVNKLGNILTSKKEALFGGHGGYYPGGQYPGGHHSGGYAPQYYPSGPSYYHKPTFFEKPHYQERPQNHYHNHYHNHQNQEPSWSGNHQGYDHGYGYRPGHGYGGNYAENPGHYAGNYGGYQGYARDDEDYDFADYNANGYYRNAKSNISADEFGQSQNNNHARSEGKVAFRDRKKRDLDNRRQFGRPPVCGPRHVCCRKNQIRPGNNRPQYGQCGVRNGQGINGRIKTPVYVDGDSEFGEYPWQVAILKKDPSESVYVCGGTLISPRHILTAAHCVKTHLGHDLRARLGEWDVNHDVEFYPYIERDIVSINVHPEFYAGTLYNDIAILKLDHDVDFEKNPHISPACLPNPHDDFTGARCWTTGWGKDAFGDFGKYQNILKEVDVPIVSNAVCENQMRRTRLGPSFNLHSGFVCAGGEEGKDACKGDGGGPMVCERQGIWHLAGIVSWGIGCGQPGVPGVYTRVSHYLDWIRQNSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HD41</accession>
    <name>A0A8J2HD41_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Similar to Gnb1l: Guanine nucleotide-binding protein subunit beta-like protein 1 (Mus musculus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HICCMSTLAB_LOCUS7026</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5093700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HD41"/>
    <dbReference type="OrthoDB" id="7668193at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19854:SF1">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19854">
        <property type="entry name" value="TRANSDUCIN BETA-LIKE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="235"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG5093700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="278" mass="31152" checksum="3BC94052AF77A904" modified="2022-05-25" version="1">MAILPPDPIYVLRGDMGPVHCLDFRISPYVEHLYAGAENGCVDIWNADGSNWILDKTIDTDYCGFSRYQILTDDIILLPLPNSQVGALSLTTQEFVYKLDPMVSKVPKPLGEVMAIKNCSLENNIILIAYESGDIAAWNIKDRVVVSWLNTDSCPMTINFDNYWMRGIIGNPTDKLEVFDLNKSNQLVHKTSITLKNSGTSVIASRPDSKVFAAGGWDGRVRIFSWKTLRPLAVLNQHRSNIFDIIYSKEKVQAFNNKNLMAAAGKDGTVSLWDLYNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HD42</accession>
    <name>A0A8J2HD42_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">MARVEL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS5660</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5090506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HD42"/>
    <dbReference type="OrthoDB" id="6347385at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="126"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="160"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="196"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="234"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="265"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="358"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="477"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="267"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="312"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="325"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="363"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="379"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="417"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="427"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="477"/>
            <end position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5090506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="499" mass="55968" checksum="3E3125FAF3280A29" modified="2022-05-25" version="1">MSETRHHLRSVSDLYAADEIEVLLLEEIRDLEPPPSAYSRPEDIQDFEIAGSRTGGAISSQSSELDSPGVHSTVHSWDSHANYHGPYGIHPHGSSSNALPWLDSNHLVLYCDVQGHLKTSTGFIRLLLLITSVACLATLCSSGTANVSLFMLPLVGRLRFIIFVAVFCLLVTTVLLFLDISHIIYMFPFNWAKLNFWLFTSIGVSYIIGCCLLGLSIWEYHLSGWVPHRTRSQLTAAAALALSCGFIAFTLSWRHGRKDISCKPSFSHENSQSQLYKPVESSSSGLTSKDRGPKQPPPWITKNQRSKKNVDTESIATSKGNGNCDEYKPGVSRKDHWASARQHFLPQDDDEMQIQSQNQAHIMQRDESDLERKRRKRRDDRDDRSSGNNGENRKADNSVNKPRRVPQKLPLQTIERPQPRKNDVRTSGKTSKTSTNSDLQNYVAATVKAWELEAAKDSEQAKAMKASLLEASMWSKQWQQPPDNVQPCSSKTIDPYSFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HD60</accession>
    <name>A0A8J2HD60_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Similar to Syb: Synaptobrevin (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HICCMSTLAB_LOCUS5933</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Endomembrane system</location>
            <topology evidence="7">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the synaptobrevin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5092129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HD60"/>
    <dbReference type="OrthoDB" id="10042941at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15870">
        <property type="entry name" value="R-SNARE_VAMP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000004">
        <property type="entry name" value="Vesicle-associated membrane protein 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001388">
        <property type="entry name" value="Synaptobrevin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016444">
        <property type="entry name" value="Synaptobrevin/VAMP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042855">
        <property type="entry name" value="V_SNARE_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45701">
        <property type="entry name" value="SYNAPTOBREVIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00957">
        <property type="entry name" value="Synaptobrevin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00219">
        <property type="entry name" value="SYNAPTOBREVN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00417">
        <property type="entry name" value="SYNAPTOBREVIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50892">
        <property type="entry name" value="V_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="86"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="V-SNARE coiled-coil homology" evidence="12">
        <location>
            <begin position="24"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="53"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="14"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00046280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAG5092129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="120" mass="13325" checksum="06D738637776CC0B" modified="2022-05-25" version="1">MDGGGYSGDGDLGNRTSQSISSKKLQQTQAKVNEVVDIMKVNVEKVLERDQKLSELDNRADALQQGAAQFEQQAGKLKRKYWWKNLKMMIIIGIICTVILIIIIVSSLPSSESTEPKESN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HFI4</accession>
    <name>A0A8J2HFI4_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="18">Similar to brm: ATP-dependent helicase brm (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">HICCMSTLAB_LOCUS7584</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5095187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6017at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048513">
        <property type="term" value="P:animal organ development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048731">
        <property type="term" value="P:system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd17996">
        <property type="entry name" value="DEXHc_SMARCA2_SMARCA4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10810:FF:000008">
        <property type="entry name" value="Chromatin structure-remodeling complex subunit snf21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.170:FF:000008">
        <property type="entry name" value="probable global transcription activator SNF2L2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:003020">
        <property type="entry name" value="SNF2-related domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.5.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006576">
        <property type="entry name" value="BRK_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037259">
        <property type="entry name" value="BRK_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014978">
        <property type="entry name" value="Gln-Leu-Gln_QLQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014012">
        <property type="entry name" value="HSA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029295">
        <property type="entry name" value="SnAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10799">
        <property type="entry name" value="SNF2/RAD54 HELICASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07533">
        <property type="entry name" value="BRK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07529">
        <property type="entry name" value="HSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08880">
        <property type="entry name" value="QLQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14619">
        <property type="entry name" value="SnAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00592">
        <property type="entry name" value="BRK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00573">
        <property type="entry name" value="HSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00951">
        <property type="entry name" value="QLQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01314">
        <property type="entry name" value="SnAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160481">
        <property type="entry name" value="BRK domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51204">
        <property type="entry name" value="HSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51666">
        <property type="entry name" value="QLQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0010">Activator</keyword>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="6" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 18" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="QLQ" evidence="17">
        <location>
            <begin position="501"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="domain" description="HSA" evidence="16">
        <location>
            <begin position="633"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="14">
        <location>
            <begin position="912"/>
            <end position="1077"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="15">
        <location>
            <begin position="1231"/>
            <end position="1392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="745"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="819"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1514"/>
            <end position="1564"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1605"/>
            <end position="1671"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="670"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="13">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="13">
        <location>
            <begin position="52"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="13">
        <location>
            <begin position="83"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="13">
        <location>
            <begin position="188"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="13">
        <location>
            <begin position="228"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="242"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="13">
        <location>
            <begin position="285"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="313"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="341"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="13">
        <location>
            <begin position="410"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="745"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="819"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="856"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="1525"/>
            <end position="1534"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="CAG5095187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="1671" mass="182744" checksum="A314B196C04B0D80" modified="2022-05-25" version="1">MASPSPSSSPMPPPQAPSPMGPPQAPSPSNPQGSPMGPPQHHPHSPTQGYPGGPPPPPGPGPGPGGPPMSQPPQPPSQQQNYPPHPHQMPPNMGPQGPMEPPPGSQGPGGPMMQGQMSGPPNSGHMGPNQMGGPRGPSHMGPGPNQMGPGGLNQMDSEGGPGPMFPGGSRAMGPGGPNQMGPGPNQMGPGGPNQMGPGGPNQMGPGGQMGPGHMGQPGGPPGPLHMQGGPGGQMGPGGPSNHMPSGPGHMSGPPPPGHMNSGPGHMGSGPGPMPPGPGHMNPSMPGGPPGPMPGGPSMGPGGPPNMCPPGQSHGANGHSQMNMSGPGSQMNMRPGGPSVLMNMGGPNASGPGPAGPMGPNSGPGNQMGPGGPMMPGSGPNQMPPGGPANQMGPGGPSPMSANNSGGPGGPGGPPGPPGIGPMPPGAQNQSLGPMGPGGPGNSMPPAPGGPPGGSGTGQENLNALQKAIDSMEEKGLQEDPRYSQLLGLRARGQSGMGDKQNFSSQQLQQLRVQIMAYRLLARNQPLSQQLALAVQGAAPPPERENRVAARIALRIEQLSNLPTNMPEDLRIKAQIELRMLRVLHLRRQLCSEILASTRKDTTLETAVNFKAYKRTKHQGLREARATENLEKQQKLEAERKRRLKHQEFLTSVLQHSKDFKEFHRNNVAKLSRLNKAVMNYHANAEREQKKEQERIEKERMRRLMAEDEEGYRKLIDQKKDKRLAFLLSQTDEYISNLTEMVKQHKMEQKRKQVEEQKRKKKKKKLEDGVPVNEDGTPAEDTRVRVIEVSTGRTLTGEDAPLMSQLNAFMESHPGWEVIESDSEDEEEEEENVSEQKAKTSESAAASDKTGDSGNNDTKKLNKAKVEDDEYKTEEQTYYSIAHTVHETVTEQASIMVNGVLKEYQIKGLEWLVSLFNNNLNGILADEMGLGKTIQTIALVTHLMEKKKVNGPFLIIVPLSTLSNWVLEFEKWAPSVVVVSYKGSPAGRRAIQSQMRSTKFNVLLTTYEYVIKDKSVLAKLQWKYMIIDEGHRMKNHHCKLTQVLNTRYIAPHRLLLTGTPLQNKLPELWALLNFLLPSIFKSVSTFEQWFNAPFATTGEKVELNEEETILIIRRLHKVLRPFLLRRLKKEVESQLPDKVEYIIKCDMSGLQKVLYKHMQSKGVLLTDGSEKGKQGKGGAKALMNTIVQLRKLCNHPFLFRTIEEKYCEHIGVQDSHTVSGPDLYRASGKFELLDRILPKLKATNHRVLLFCQMTQLMTIMEDYLGWRGFMYLRLDGTTKAEDRGDLLKKFNDPGSQYFLFLLSTRAGGLGLNLQAADTVIIFDSDWNPHQDLQAQDRAHRIGQKNEVRVLRLITVNSVEERILAAARYKLNMDEKVIQAGMFDQKSTGSERQQFLQSILHQDDADDEEENEVADDETVNPMIARSEGEIEIFAKLDLERRREEAKLGPNRKPRLLEEIELPDWLIKNDEEVERLTYEEDDERYLGRGSRQRKEIDYTDNNLIGKEWLKAIDDDGVEYDDEEEDDRKKKKTRKRRKRGEEDEEPTPKKRRGGSSGSGAGPSVDSKLRRAMKKLLMVVVNYTDSTDEASPIHEDSIVLGSVFTNARQRLEAEGSMSDDGNNSSPGECDDGSDGDSSVRMKIKLKSRKSESRSGSRRKRITKKYISDDDDDVDDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HHQ5</accession>
    <name>A0A8J2HHQ5_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS10565</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5101663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HHQ5"/>
    <dbReference type="OrthoDB" id="6776738at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5101663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="62" mass="7250" checksum="6FEF0EE1FFE27307" modified="2022-05-25" version="1" fragment="single">WGLIDRIGIFVNQQRVSRWAYITPNGILVTRDGLIVKDPQNSLAGIHREYIYTTWTRFVDIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HHR7</accession>
    <name>A0A8J2HHR7_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CHK kinase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS9110</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5099540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HHR7"/>
    <dbReference type="OrthoDB" id="191037at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015897">
        <property type="entry name" value="CHK_kinase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004119">
        <property type="entry name" value="EcKL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11012">
        <property type="entry name" value="PROTEIN KINASE-LIKE DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11012:SF30">
        <property type="entry name" value="PROTEIN KINASE-LIKE DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02958">
        <property type="entry name" value="EcKL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00587">
        <property type="entry name" value="CHK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CHK kinase-like" evidence="1">
        <location>
            <begin position="128"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5099540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="316" mass="36984" checksum="4FDC936A1EFB4F67" modified="2022-05-25" version="1">MDNEDRIELVEEIIPEIVHNRCFCDPGSREFIELDSVSIDKVSEGSSEVNDKKCELLRGKIVIKFSSEPKTFFVIIKLLSQQATEDDEDYKYFANEEMFYNKMTLEYKLDIYPKLYVADMGRYGRPIIVIEDLQAVSGYRRVHSKLDEDHLRMCLKAIARFHGRGLRLKCDKFNTFREFYAKLLHTNNISDYSLHVNLTNKVAQYLDEHPNVDRRILKLFKEFKQEAANKDTEFLTICNGSVDLNNLLFRYENSKPMDVKIINWGSMRYSSPVIDWQIITSSQIGENLSNIDIQRLLDDYLTVLIEEYPGIVDNVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HKU2</accession>
    <name>A0A8J2HKU2_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS12285</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5106488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HKU2"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5106488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="139" mass="15083" checksum="6DD5C3F50E5A34B0" modified="2022-05-25" version="1">MSVLTEFLNYTFNLFCLQKLEKILALISSRSHGAGNFFTVDADAPAYQPVSGALFWLVSTGLVALRNVPAALLLGNAEHLGEHPVLAAGAQPDRKQTNSSAARVTLTALLRSGAVQIVLTRRATDSWLFRRAFSRSLQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HLS2</accession>
    <name>A0A8J2HLS2_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS8381</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5096779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HLS2"/>
    <dbReference type="OrthoDB" id="7696379at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58104">
        <property type="entry name" value="Methyl-accepting chemotaxis protein (MCP) signaling domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CCHC-type" evidence="2">
        <location>
            <begin position="240"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="2">
        <location>
            <begin position="263"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="278"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="290"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="337"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="357"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5096779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="377" mass="43085" checksum="3D42738C1801AEF0" modified="2022-05-25" version="1" fragment="single">MNEMYGNLVFECVVAKLQSVFKLDENHPNESVDVKIQGNKEANKSFLTIDEWNALVEWVGNWKGETPVMPRTLNQRISEEIDENELLGGDDEIKTNAKDDNTTSDNEECETKRVITTHAVIETTDNSKVVQTEKTLANDVSGDWKPSFQAMSRMLQQHTKLLTTAVNTIKGLERVQKEFANAKNEQYLVQDQINDRMSEIERNMEQIKDCMQAQAEANKKQIRSVDTRATLMAKKDSKVRCFECGDYGHHSYEYPRKGSGLQKCYECNQFTTHKAKDCPERLERQKRNASRGNGKTSGTNRYGYFKNSRGFKQANDRRQYLKRKNSDNSGNSESKKPRFGAHRGRGGFKNSNQHRQNKNEKAKGTESAKGDKSDQQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HME1</accession>
    <name>A0A8J2HME1_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Similar to NTN1: Netrin-1 (Sus scrofa)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HICCMSTLAB_LOCUS8837</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5097707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HME1"/>
    <dbReference type="OrthoDB" id="5984158at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005604">
        <property type="term" value="C:basement membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009887">
        <property type="term" value="P:animal organ morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016358">
        <property type="term" value="P:dendrite development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008045">
        <property type="term" value="P:motor neuron axon guidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009888">
        <property type="term" value="P:tissue development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00055">
        <property type="entry name" value="EGF_Lam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000048">
        <property type="entry name" value="Netrin 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050440">
        <property type="entry name" value="Laminin/Netrin_ECM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002049">
        <property type="entry name" value="LE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10574:SF365">
        <property type="entry name" value="NETRIN-A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10574">
        <property type="entry name" value="NETRIN/LAMININ-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00053">
        <property type="entry name" value="EGF_laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00180">
        <property type="entry name" value="EGF_Lam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01248">
        <property type="entry name" value="EGF_LAM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50027">
        <property type="entry name" value="EGF_LAM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 8" id="KW-0424">Laminin EGF-like domain</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Laminin EGF-like" evidence="10">
        <location>
            <begin position="8"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="101"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="107"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="142"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="8"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="10"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="29"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="41"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAG5097707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="159" mass="17676" checksum="482F683F95FE795B" modified="2022-05-25" version="1">MIMKIKTCDCHLIGASGKTCNQSTGQCPCKDGVTGTTCNRCARGYQQSRSHIAPCVSEWKIFFLSVQKHVLIPLTNCTKYSRGKIHFDRFFGEIPQVIQTQGIAGEDNGEHDYDDGEADDRGYDGRAAKSHAGSDSQTSLKVNREKEEKESQARSLRKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HMJ8</accession>
    <name>A0A8J2HMJ8_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS12530</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5106990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HMJ8"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5106990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="78" mass="8522" checksum="4B11FEBB49EDA8F1" modified="2022-05-25" version="1">MRIVPSIIVYNHSGYLISVIPPAHYSSVSWSILCKPIISFAEVIKNTAATVMSVGSKNNRWTGVCIASDPSAVNRKHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HMM4</accession>
    <name>A0A8J2HMM4_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Staphylococcal nuclease domain-containing protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HICCMSTLAB_LOCUS11772</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5103963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HMM4"/>
    <dbReference type="OrthoDB" id="10023235at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031332">
        <property type="term" value="C:RNAi effector complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006402">
        <property type="term" value="P:mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031047">
        <property type="term" value="P:regulatory ncRNA-mediated gene silencing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00175">
        <property type="entry name" value="SNc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20433">
        <property type="entry name" value="Tudor_TDRD11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.140:FF:000018">
        <property type="entry name" value="Serine/threonine-protein kinase 31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.90:FF:000001">
        <property type="entry name" value="Staphylococcal nuclease domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.90:FF:000002">
        <property type="entry name" value="Staphylococcal nuclease domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.90">
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016685">
        <property type="entry name" value="Silence_cplx_Nase-comp_TudorSN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035437">
        <property type="entry name" value="SNase_OB-fold_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016071">
        <property type="entry name" value="Staphylococal_nuclease_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002999">
        <property type="entry name" value="Tudor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047386">
        <property type="entry name" value="Tudor_TDRD11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12302">
        <property type="entry name" value="EBNA2 BINDING PROTEIN P100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12302:SF2">
        <property type="entry name" value="STAPHYLOCOCCAL NUCLEASE DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00565">
        <property type="entry name" value="SNase"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00567">
        <property type="entry name" value="TUDOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017179">
        <property type="entry name" value="RISC-Tudor-SN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00318">
        <property type="entry name" value="SNc"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00333">
        <property type="entry name" value="TUDOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50199">
        <property type="entry name" value="Staphylococcal nuclease"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63748">
        <property type="entry name" value="Tudor/PWWP/MBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50830">
        <property type="entry name" value="TNASE_3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50304">
        <property type="entry name" value="TUDOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="TNase-like" evidence="8">
        <location>
            <begin position="10"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="TNase-like" evidence="8">
        <location>
            <begin position="158"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="domain" description="TNase-like" evidence="8">
        <location>
            <begin position="296"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="domain" description="TNase-like" evidence="8">
        <location>
            <begin position="478"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="domain" description="Tudor" evidence="7">
        <location>
            <begin position="685"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="100"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="325"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="105"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="331"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR017179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAG5103963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="860" mass="96813" checksum="64F12D3417B8B9AA" modified="2022-05-25" version="1">MSSNSTTSNDIKHGIVKLVVSGDTITIRGQPRGGPPPERTIALSNIIAPKLGRRGVNNGEDIRDEPWAWEAREFLRKKLIAQEVVFVEEKSVSATKVYGSRDNVRNPSPAQSRLQELEDAARSAGKGKWSGSPLSEHIRDVKWTIETPRTLVDKYNGKPVKAIIEHVRDGSTVKVFLLPDFYHITLMLSGIRCPQIKTEGEEPFARQAQYFVETRILQRDVEVILEATNNNNFVGTILHPAGNIAEHLLREGFAKCVDWTMNFTKSGVDKLYMAEKAAKERKLHLWQNWQPSAPQKEYNAVVVEITSADSMLVRTQNGETKKIFLSSIRPPQREKKAGEDKNAPRSKDFRPLYDIPFMYDAREFLRKKLIRKQVKVIEDYTQPAKDQYPEKICCTVMVGKVNIAEAMVSKGFATVVRYKQNDDQRPLHYNELLAAESKAEKSQNGLHAKKDTAPQRIVDLSNDAAKAKCHLSALKRTRGTKAVVEFVTSGSRLKLFLPKEHCLITFLLAGVKAPRRSRPKPGGGTIEGEKYAEEAFNFMKEQCFQKDVEIQVDNMESKGSGFIGWLFVDGVNMSVALVEEGLAEVSSFSEHGEYIKSLKAAEERAKAKKLNIWDRPDAEPEEEEVKEEKEVVERKVETREVVVSEVTEDLHFFAQYVDQKNQVEGLLTRLRQELEENPPLPGAFSPKRGDLVAAKFSGDGEWYRAKVEKVAGTNISVLYVDYGNREVVNVTQVAPLPAEFSGEKPYAHEFVAAYVALPKDVDDQKAAITAFQEDIENKTLLLSVVYKSSSGVLAATLVDPVTSEDIVKALVKDGYLLVNREKRVYVKPEYLDAQSEAKKAHRNIWQYGDITTDDNENAWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HMQ5</accession>
    <name>A0A8J2HMQ5_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS12575</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5107079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HMQ5"/>
    <dbReference type="OrthoDB" id="44061at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="83"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5107079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="174" mass="19457" checksum="227CE7B7CF1BBC9B" modified="2022-05-25" version="1">MNLSEAILVYISLAIAVLLLLGILKWIIGFCIPGVSQWGLNVLVNGSCAEMDISSRDSGRSIDIFRKSDRPQTIRICSRKLEFFLNLTFFLTFPIAVCCNLCNGSMVKMQDCSDESHTRLIDGNTSTKTTPKNNYGELNHISSTHELEEAQNIKNQLIESREASNAERKLSKAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HMS7</accession>
    <name>A0A8J2HMS7_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HICCMSTLAB_LOCUS11579</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5103577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HMS7"/>
    <dbReference type="OrthoDB" id="19174at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="15"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG5103577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="495" mass="58407" checksum="7338CE1247D0778D" modified="2022-05-25" version="1" fragment="single">YRRYKMDPELNPTTAGNSLVYQAIQENNLEDLIKLLLEDGMNVNEPIITTGEFSGFTALHVACMKNRDSLVESLVNYCKADVNAMAADGTQPIHLACFYQSLHKSNSKIKTLVEANANVNAEFGKEIFSKHIKDEEWFPYFGAKMPLAAYTVIYDKPSIIYDLKQVNLNIISLTNKTLLMYAAENYYYEYISIIMSNIEDPELRDKLINHRDCDDVPLTHYPFYPKKYDQFAHRKMRVTFDYFLYSKFFSEVSKWGADMYALIKNDPVTFLPNLLVYRCCPMLLEDCLPYYTTVSLYWIVYYAALSKEESFKQYLARVHPVMQPVNNLSPIRENRKDCIDIAVKDLVFRVVFRLPVQNEDIMLMNKFIVSDVNLSDIVNDYRENFIEKELQERFIEFGDHKMTMYDFLWQVFDYKKLKFLMREENLLDALDKVVIQNLVFRSAFRLPVQKEEIKLMDKLIASDENLRKINHFIEFGDNKMTMYDFLMQVFDYKKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HMT6</accession>
    <name>A0A8J2HMT6_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">protein-tyrosine-phosphatase</fullName>
            <ecNumber evidence="1">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HICCMSTLAB_LOCUS11594</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="1"/>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5103607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HMT6"/>
    <dbReference type="OrthoDB" id="9993594at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030054">
        <property type="term" value="C:cell junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009653">
        <property type="term" value="P:anatomical structure morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048666">
        <property type="term" value="P:neuron development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14547">
        <property type="entry name" value="PTPc-KIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000242">
        <property type="entry name" value="PTP_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008356">
        <property type="entry name" value="Tyr_Pase_KIM-con"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46198">
        <property type="entry name" value="PROTEIN-TYROSINE-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46198:SF4">
        <property type="entry name" value="PROTEIN-TYROSINE-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00102">
        <property type="entry name" value="Y_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01778">
        <property type="entry name" value="KIMPTPASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00700">
        <property type="entry name" value="PRTYPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00194">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50055">
        <property type="entry name" value="TYR_PHOSPHATASE_PTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="11" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="136"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="9">
        <location>
            <begin position="345"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="10">
        <location>
            <begin position="491"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="178"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="active site" description="Phosphocysteine intermediate" evidence="5">
        <location>
            <position position="511"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="483"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="511"/>
            <end position="517"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="555"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR608356-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR608356-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAG5103607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="583" mass="64019" checksum="C157474294D70AF5" modified="2022-05-25" version="1">MDSMPKFINSNYNLQLLNNCRSMEQCDSYHGSTGTPLSQWYISDVGYGNSNDDSKTISLERIYLITQQNQEKSVLPISLLPVTEGMSSSPKHRIRQSSTGLDDAGMDLQASQLGTRAGQEISSTAAVSWTNWKLPFPVIVCAIAGAILLTFLILLWLRKQMSSEKKSSDGDRRELVEKGAVDGSSSSSSLDKPGKSTQEWSMEAKWVHQPAAKPSSVSVQTVPVTRAVSLSTGGLVCNLPQVLTVATPERRPEPIRIKAKGSLLERRGSSASLTIELAPAPGSPPHVVTPTRECTSEEFLLSAGNVLSRMQLKKVIQDPSALHKEFWEVPLNLPEKVDIFGAGVKNRYSGVLPNPQSRVVLRGSDDPVASYINANYIRGYDGESNRYIATQGPLASTVADFWRMVWMDKVSGVVMMTRLFEAAKAKCDVYFPLENNSRIQAGPFTITVTSITNRDGYMIRDIELRHENERRNVTHYWYDSWPDHAVPQAADSLVSLAAEINTLPGPVVVHCSAGIGRTGCFIALATGMIQLARDGNVDVLGILCQMRYDRGGMIQTAEQYEFVHKALCLFEQTLDGKVPTTGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HMV0</accession>
    <name>A0A8J2HMV0_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS11624</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5103667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HMV0"/>
    <dbReference type="OrthoDB" id="7679971at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035315748" evidence="1">
        <location>
            <begin position="21"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5103667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="217" mass="25195" checksum="8AFDDC19AF482AAE" modified="2022-05-25" version="1">MNYITSLFFIFSINLLKTNGSPQITKLVPLDDWVAFKERTSQVNPLDKFFGKLRATYDFIFHRPDNVSNVEKIIADDKSWATENSNNKNHDRLITPMLPLFNHIVFKNNNSNKKSEIDMNKNLYIRLYPEENLMSTYESSISRISKDDEWPDDVETVEPLSQVEIDNENIDRSVEAVTPSQSSFQFPIAVVRAFAKWLESILSYTHQAYSAFARKNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HMW1</accession>
    <name>A0A8J2HMW1_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS9169</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5099657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HMW1"/>
    <dbReference type="OrthoDB" id="6373466at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035217103" evidence="1">
        <location>
            <begin position="26"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5099657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="80" mass="9562" checksum="0B89922D220BF70D" modified="2022-05-25" version="1">MADRDALPRQLLLLFVLLLARTCWWNEVCKEEFHSKFRCRCPRWSYCRAPGKYYDAHCSITRTGYIWTQPEMSLATEAEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HNV4</accession>
    <name>A0A8J2HNV4_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">HICCMSTLAB_LOCUS11327</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5103073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HNV4"/>
    <dbReference type="OrthoDB" id="504170at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14340">
        <property type="entry name" value="UBA_BRSK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000003">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048622">
        <property type="entry name" value="BRSK1_2-like_UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF36">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE BRSK1 ISOFORM X1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21115">
        <property type="entry name" value="UBA_BRSK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 16" id="KW-0418">Kinase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="15">
        <location>
            <begin position="25"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="277"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="287"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="341"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CAG5103073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="432" mass="47507" checksum="CC6246CA31EED25E" modified="2022-05-25" version="1">MTAVPGKESPVVLNTQETHQYVGPYRLEKTLGKGQTGLVKLGVHCVLGKKVAIKIINREKLSESVLMKVEREIAIMKLIDHPHVLGLSDVYENKKYLYLVLEHVSGGELFDYLVKKARLTPKEARRFFRQIISALDFCHTAGKGELELELSMMEVVQTHVIPSVELIDPDVLQAIASLGCFKERDKLIQELLSPNHNTEKVIYFLLLERKRRRPACEDELEGIRVGIRGSSGQSEVDPPRKRVDTCRVNGNTTLNLGQISHGSPLTPRRQSRIINSFDSARHHTRRSPSTGSHTHLSHSHASTPGSSPMHSPNVAGLLSPHRAVPNSHHGQNPSPHRLSITSGSASGNGTMASTTTTTTVSTTSATSQPFSNVAIELNEIQSIGITPPGSPHTGTGTGAHHWRSRLTTIKNSFLGSPRFHRRKLLTSTEEAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HNW3</accession>
    <name>A0A8J2HNW3_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Similar to ANK1: Ankyrin-1 (Homo sapiens)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HICCMSTLAB_LOCUS13876</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5109240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HNW3"/>
    <dbReference type="OrthoDB" id="194358at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="81"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="115"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="152"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="185"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG5109240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="432" mass="49563" checksum="DDCF4F6E4449AB6B" modified="2022-05-25" version="1">MENYLDMSNAWPMPLYSEVADSNTNKVLPHQHKSVNSDDYNLCVQQTSLCHFIGTEQVQSVKILLNQGAAVNVTMSSPHYTGYTLLHYAVERSNAEIVELLLKNGAHVDASTVENRLKPIHIAVMRGNYDIIKYLLIYKAQIDATFDVAISKEYSCLHLAAQNNDLNVIKLLLESGADINLQDKEKRTPLHLAIQAAQVEAVNLLLKYHPNTMLKNCQQQTPLIFALDNMCPVLFLRVNNIEDLVKLRLQHQYSGCKCEIITHTLVRHLIKLKVANFKIDEKDQEIILLSETYRELESSCSNELEQMQVLVVKNMTIQKLRDLQAVTHLELLSLFRGEPVIREPRSQTLKRDQDINNAWILYEQNILNIQSFLAYASFFLKPAYQEEEQNLNNMDIATDEEEDVLEVGGVILQPPEYYYAMEVFHEIDVVFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HP89</accession>
    <name>A0A8J2HP89_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Similar to sw: Cytoplasmic dynein 1 intermediate chain (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HICCMSTLAB_LOCUS12201</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the dynein intermediate chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5106320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HP89"/>
    <dbReference type="OrthoDB" id="4189at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005868">
        <property type="term" value="C:cytoplasmic dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045504">
        <property type="term" value="F:dynein heavy chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045503">
        <property type="term" value="F:dynein light chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010970">
        <property type="term" value="P:transport along microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000781">
        <property type="entry name" value="Cytoplasmic dynein intermediate chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025956">
        <property type="entry name" value="DYNC1I1/DYNC1I2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050687">
        <property type="entry name" value="Dynein_IC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12442:SF22">
        <property type="entry name" value="CYTOPLASMIC DYNEIN 1 INTERMEDIATE CHAIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12442">
        <property type="entry name" value="DYNEIN INTERMEDIATE CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11540">
        <property type="entry name" value="Dynein_IC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 7" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="473"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="72"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="18"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="72"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="91"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAG5106320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="655" mass="72886" checksum="7CE7B6C585BADFB8" modified="2022-05-25" version="1">MMSDRKAELERKKAKLQAIREEKERRRREKEQKDVEEATVRAAGTDKDHRKELDAMLSSLGVAPVSDVLSSLSSMNSLASDQSANATPDASIQPSSITSPQSGSSKKRSNRELTVVSVAHTNIPPKEPVVYSKQTQTAQTTQTSHDVLTYDDGQAEDEENSLPHIDGFQSKLPPGILPHGLPQVKEVLPAVTQDEQQKEPEKPKEIRELSEEEKQMIILSEDFQRFLDKTSRLVERALAESVDIYTDYTGTLDGEDGMDEKSHQRLWLNRSFFCDRWSRNRCVTSMDWSPQFPELLVASYNSNEDAPNDPDGICLVWNTKFKKTTPEFIFHCQSAVMSTTFARFHPNLILGGTYAGQIVLWDNRVQKRTPIQRTPLSASAHTHPVYCLNVVGTQNAHNLISISTDGKMCSWSLDMLSMPQESLDLQAKQSKPIAVTSLAFPHGDVNNFVIGSEDGTVYSACRHGIRAGVTETYEGHQGPVTGVSAHAVQGGIDFSHLFLTSSIDWTIKLWSLKENKPLYSFEHNGDYVYDVAWSPTHPALFAAVDDSGRLDLWNLNQDTEVPTASVVVDGCPALNRVSWTPSGLHVTVGDDSGKIWVYDVAENLAHPRGDEWNKFLYTQQDLKNNKADDELDKLNLNSGPSSLTSLSSMSSVPIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HPM9</accession>
    <name>A0A8J2HPM9_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to c2cd3: C2 domain-containing protein 3 (Xenopus tropicalis)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS11746</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5103911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="79771at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034451">
        <property type="term" value="C:centriolar satellite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005814">
        <property type="term" value="C:centriole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061511">
        <property type="term" value="P:centriole elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071539">
        <property type="term" value="P:protein localization to centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057537">
        <property type="entry name" value="C2_C2CD3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21254">
        <property type="entry name" value="C2 DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21254:SF1">
        <property type="entry name" value="C2 DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25339">
        <property type="entry name" value="C2_C2CD3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2CD3 N-terminal C2" evidence="2">
        <location>
            <begin position="9"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="217"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="522"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="747"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="876"/>
            <end position="906"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1105"/>
            <end position="1132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1183"/>
            <end position="1269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1486"/>
            <end position="1511"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1663"/>
            <end position="1709"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="217"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="522"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1109"/>
            <end position="1118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1119"/>
            <end position="1129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1200"/>
            <end position="1248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1249"/>
            <end position="1264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1487"/>
            <end position="1507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1663"/>
            <end position="1677"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1698"/>
            <end position="1709"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5103911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="1709" mass="190465" checksum="2151E726CCB42F91" modified="2022-05-25" version="1">MDRKYLSQRSLPPLVEGKVHGYLDLTIDKIVWTRRSPGSVTVVACCPSETTKDTRDNTETYSIKTNFELFKEYLKNAESLSLSVLSKKTQQSIGTASVTNLLEIFSGKLVTSVSIYSPTGLKLGEINICLQLSRPQKNKPRKREKMPEIEKISSVRSIYFSEINSDLDSPRLTSDNYRSILREKRTNLENKKNPLDLTDRLVAQVVARARKLRGALSNDSSDPLALSDSTIDSYRSDESAEKEAALYKYLMGSSMSRRKEKKALETLRTQSPTPSLIDFAVETIRSCNENHPPQSTDLDNNNQYLTSIPKEESSESTTANRWSVQRKEASPIDYVDSVRIVVDSLKLTPAGFRRVKSSCLSKSDFPVSVTYFVQYDPSFLTIKKVNKKTSCENKPVKMCSKQQEEENVYFNHEAVYNLPKSYLRMEVPLRFKVFNRHLNQRTPAELGICSMYISDAARSSTLGTTQRLAVVKKGIKIGELKVSVELGCDKTHFGKQFVEAVTSTKENIPVLELSPNFASSRYKTATGDSKSSRATSAPEKKESLSWGGNNNCNYNNIDRNIEKKRSVEVEDVPRFSTENTLLHGLIYISDGRDLPDVSTYLICRTFWREDRSVSKVCTGRNPYYNFYQLVPLIHNLELLERTKDNCIITEVYSKNATDDSLIGIAKLPVHQLYVAYRDPLVLQHLLRAKYPVISVDGWVAVTDPVSGRHCGEIYALVALGTAEQIALLEMTRGIRTHTNLPSVSAPAAGVAADNRQRNESPAVKTQECQTEITVDAKHTQEDQNNRDEAVIHTIVDRLAQALSAPKTIVDQGAQTEFKFQNEPPRDKERQKIIHVEPLCLDNLNNSQSFSAESSTDSPQDNFNMSREIFRSVGVGAEFDEPPDQTRSSNTCDHPSDSDDNVAGTSFHLADNPSRDYLAADVDSCHSDKDVSNEKAFKVMVEIDCALHLPKVEVNNEILEPCTYVTFQKFRTNDTNRIDAYMITNVCPYSSSPKYEWRCETKLPTDLLIKEEKRLVMKVWRLLAPDVSMSINLEKDILVGISAIDLSVLTSGFPTISGWYHIMDFGGKSNGQLKISITPLENVVGLGKSVTTRPVSAFNYTNLSSPYSDDLAKQDHEGQEQDSEEEEDQNPAESLRFRLNEVTSKAFEDLAQQFDPTEQDFEFEDNENDKENDLDNINVPWLSQPPAVSNSVDHPRDISERTINGNGTEARPSGTTSTVDTGYSSVSNTRSAASLTNGHYNPTKNRLLQSSTNTNINGSSNGINGKDSRVNAEHSPYRVENPCVRNNKTACSNPGVFNLDLNNSSVPLTNNQYRDRDTNQPVRGTRMHINHLLDKLSPQSPIVPPAIGNSPMKRSIMDLLSSLRHNNNNNNNNLSNNVKCNREVNLRTVPTQTENYTSNSRLFNLDSSKWLYHGREIGRDDAEIPAKTQKREKISTVIREELIADDQNNDTVEYDFLSAQLMTSNVRHMGSLNPLFYPHLIPDVPISDGQSAGANNDRQENNSTSLNSGEADEAVERLDNRYVESFNATINKSLKRLRDQDVNSSHKSTSTSEIDHMSTVALGDSADVGYFGAIETGEVSRVTPSGVSENVDGNIDVTVIHKPCNDDLMACNSVGSTITTTGAMVITPSTMTTVAITTTSTSTNTTSQLLYDNDMQTVSEINDNTSLNSSETSVSVISRQAPDGGNPIEDPGRFVSKPNNHEHDDSSSES</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HPX6</accession>
    <name>A0A8J2HPX6_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BED-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS14105</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001892">
        <property type="protein sequence ID" value="CAG5110868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HPX6"/>
    <dbReference type="OrthoDB" id="7616206at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5110868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="154" mass="17798" checksum="12BAD1625397A307" modified="2022-05-25" version="1">MNVDILSKSESNSQSEVETEGTDNETELDQNQKEFHNKIENSPLLSETFFTIDVTQSTDKNLIAECNFCHPKKIIRGSTRTTSNYTSHLEVKIKSRWSCVFDQETFEKNVTTYVLKSLLPFSSVEDPHFRKIFDVSSLHKPFLNSNMPLRKCQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HPY3</accession>
    <name>A0A8J2HPY3_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Similar to caz: RNA-binding protein cabeza (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HICCMSTLAB_LOCUS13565</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RRM TET family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5108929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HPY3"/>
    <dbReference type="OrthoDB" id="76445at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12534">
        <property type="entry name" value="RRM_SARFH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000574">
        <property type="entry name" value="HIV Tat-specific factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1060.10">
        <property type="entry name" value="Zinc finger, RanBP2-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034870">
        <property type="entry name" value="TET_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001876">
        <property type="entry name" value="Znf_RanBP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036443">
        <property type="entry name" value="Znf_RanBP2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23238">
        <property type="entry name" value="RNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01228">
        <property type="entry name" value="EGGSHELL"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00547">
        <property type="entry name" value="ZnF_RBZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90209">
        <property type="entry name" value="Ran binding protein zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01358">
        <property type="entry name" value="ZF_RANBP2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50199">
        <property type="entry name" value="ZF_RANBP2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RRM" evidence="11">
        <location>
            <begin position="192"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="domain" description="RanBP2-type" evidence="12">
        <location>
            <begin position="339"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="129"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="280"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="364"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="53"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="68"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="89"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="129"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="285"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="312"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="328"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="371"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="398"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="433"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="445"/>
            <end position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAG5108929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="456" mass="45194" checksum="8F7A99AF1C8F8472" modified="2022-05-25" version="1">MADNQYSSYQQQSYGQYSQPPPSGDQDTSYPPPATGGSSNYNQYSQPPPSSGGNYGSYNSGGYGGAGQDYNSPSQGQGNYSSGYGGAGAANHSSGNPSPGGNNYGSGYGSSGGGGGGSYRGNSGGSGYGGQGGGGGGRYGSDRGSYGDRSSGGGGGGYKMKSFVATEFKIKCVTGGYGDSNGGNDRMVVQEDTVFVSGMNTDITEDEICQHFGAIGLIKNDKRTGKPKIWMYKDKSTGKSKGEATVTYDDQAAAHSAIEWFNGKQFKGSTIKVQIAQHKSNWQGNRGGGGGGRPSGGGGRGGGGGRGGFGGGRDRDEHRGGEDRGGRDGGGGGGGAGGRGGDWRCPNPDCGNTNFAWRDECNLCKSSKPEGAGGGGGGGGGGRGGGGGGGRGGDRGGRGGGFRGGRGGGGDRGGDRGGRGGGGFRGGDRSGGRGRGGPMRGGGGRGDRDRDRQRPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HQW8</accession>
    <name>A0A8J2HQW8_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Mitochondrial (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HICCMSTLAB_LOCUS12527</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bL9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5106984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HQW8"/>
    <dbReference type="OrthoDB" id="5555409at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019902">
        <property type="term" value="F:phosphatase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.5.10">
        <property type="entry name" value="Ribosomal protein L9, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026142">
        <property type="entry name" value="Pro_pase_1_reg_su_36"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009027">
        <property type="entry name" value="Ribosomal_bL9/RNase_H1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020070">
        <property type="entry name" value="Ribosomal_bL9_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036935">
        <property type="entry name" value="Ribosomal_bL9_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21055">
        <property type="entry name" value="PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT 36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21055:SF3">
        <property type="entry name" value="PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT 36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14895">
        <property type="entry name" value="PPPI_inhib"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01281">
        <property type="entry name" value="Ribosomal_L9_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55658">
        <property type="entry name" value="L9 N-domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal protein L9" evidence="4">
        <location>
            <begin position="74"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="715"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAG5106984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="715" mass="84166" checksum="9F87538E4185C04B" modified="2022-05-25" version="1" fragment="single">NFASVFNNLTKSISPLLNKTPGVVIQQTRNTFVLKRQYKLPLLEKGAQIKNWKNRYFIYQLVENRNNRKREQIDVILKTFVEGMGVRGDKLSLSPYYAYKHLLLPGLAAYATPENIKKFQEDIGVPQQAYSSPFVPQTIRLLGEFLLQVNMSADNPWTLATEHVWSAFRENKIHMSRDSVTLPERPINGPNLEMENKEFYVTVTINQREKINVRCRIRYRSNDPNKLMPDPDALLKRSEPIYPEFKAVLDAIPVHSQLKQKLQQDSSTLKNYEDDVHFVWDDFRKELAIFGAHEQEDQKIKYRRQRKKIIDKSKIYCPHAYLILSFSDILNSNQKLRYRRYYLRKVSPNEPDVIILQDIKNLVLYLLTTPVSLQFINFFHLRIVDRLLRALIIYFQSYTQIWEEEIIKKRTPVTKKARNQLAKGSRLKKAEEMSTLRSIVAREYCELLVGCEESAKYHHMLAGSSIESHGEKDLRIFEVFIQVAHRVVWIALQRKYYNLIEVELHRLLRTDAYNIADRKTGYETNKGMDEEEKFILHGSEMLPRRKLLINSPLSYQLLNEFNDYRLVSLGLINSESKDPRINYLKNALLADEENIQKLRVKVGILGHQRANYDITLVPIDGENELDREELWERRRSSLSDKRRKSLSLEQEPLELRDFGDDLELSDVYDLSKVQVVEGKYDKYREEARKKWIKRELNRQSYSSYSDAISIITTTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HRL7</accession>
    <name>A0A8J2HRL7_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS13383</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5108730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HRL7"/>
    <dbReference type="OrthoDB" id="6436112at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="120"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="38"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5108730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="160" mass="18099" checksum="B4A14A384A689456" modified="2022-05-25" version="1">MSYEHPTPVTGKTQTRNPLKNVTPETRTKTEPCDEMPAHSQSQSSSSQQQPQQSQSQSSQQSHQQPPQQQAQYRESQVPRPPQQPTTPDAIKPGWGYGLDLIGGQASAFWQNYQESLAQELEQERKSRQHQATERDQVKSPLQESRTGYYKNSVLFTSAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MDB1</accession>
    <name>A0A8J2MDB1_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Poly [ADP-ribose] polymerase</fullName>
            <shortName evidence="5">PARP</shortName>
            <ecNumber evidence="5">2.4.2.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HICCMSTLAB_LOCUS4110</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>NAD(+) + (ADP-D-ribosyl)n-acceptor = nicotinamide + (ADP-D-ribosyl)n+1-acceptor + H(+).</text>
            <dbReference type="EC" id="2.4.2.30"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.-" evidence="5"/>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5084461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MDB1"/>
    <dbReference type="OrthoDB" id="429950at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003950">
        <property type="term" value="F:NAD+ poly-ADP-ribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990404">
        <property type="term" value="F:NAD+-protein mono-ADP-ribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006302">
        <property type="term" value="P:double-strand break repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070212">
        <property type="term" value="P:protein poly-ADP-ribosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.228.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050800">
        <property type="entry name" value="ARTD/PARP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012317">
        <property type="entry name" value="Poly(ADP-ribose)pol_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10459">
        <property type="entry name" value="DNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10459:SF60">
        <property type="entry name" value="POLY [ADP-RIBOSE] POLYMERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00644">
        <property type="entry name" value="PARP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56399">
        <property type="entry name" value="ADP-ribosylation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51059">
        <property type="entry name" value="PARP_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3 5" id="KW-0520">NAD</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PARP catalytic" evidence="6">
        <location>
            <begin position="260"/>
            <end position="489"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00033987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAG5084461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="491" mass="57102" checksum="654EEEDEA1E41734" modified="2022-05-25" version="1">MAIGNVLCLVGFYGFYRLYQCLKKIFEDLEPTVTNNNDGYSRRIPSEPDEKTYFTASQTTFSRREPTESERKIYSSLSQNGTLKTINPPKPEKNLRINPVLRREPTELERKIYSSLSQNGTLKTINPPKPEKNLRINPVLRTKQTERERKIYSSVPGNSIVSKINPPIYKEDGGPKVNNFLAWMIDLTTVKNELSLRNIHNRSTCLSQKNFLKTIDMIPNLSVDIKYDIVRILLRSSRRQFNNKKYNNNNDDNNNKVQKKFLDIFYEQLKAKMVLLDKNSKRYELIKMYIANTHSRHHYQYEIQVNYIFDTYRYEDRKKFNNNIGNKKLLWHGTKTNNVISILQNGLQLNPDIPSVHSALMFGRGIYFTNSVSKAANYCGTCGSTRNEYGVLFLCEVALGKMKICNEAEPNIRLPHHLDSVYAMGQLTPNSKYVRTIYPDVKVPCGRIIEEPSNRNNLLRHDEFVVYDQEQIKIRYVVSISFKYNANQGLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MDQ7</accession>
    <name>A0A8J2MDQ7_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS4186</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5084736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MDQ7"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="57"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5084736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="180" mass="21059" checksum="7FBA31285DD8B7D7" modified="2022-05-25" version="1">MPNGKEANQAGSSNWFQGNFKLGRSISVGELKEWNLEKDKEDRELIKKSKLQLKTINKGKELNAEEMETLMKKLEDLDERIKQECKKVSDEVGVLRMEGKKEREEMKKIWEAEKKIKKEKIKGIKDRLDKLEQERVMVEKVEDGGGERPGKVMDAERRLRKLEWGGREKGKRVKEKECNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MEZ9</accession>
    <name>A0A8J2MEZ9_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HICCMSTLAB_LOCUS4595</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5087738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MEZ9"/>
    <dbReference type="OrthoDB" id="2649at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050684">
        <property type="term" value="P:regulation of mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000245">
        <property type="term" value="P:spliceosomal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000642">
        <property type="entry name" value="Serine/threonine-protein kinase srpk2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000163">
        <property type="entry name" value="SRSF protein kinase 2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000275">
        <property type="entry name" value="SRSF protein kinase 2 isoform X3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051334">
        <property type="entry name" value="SRPK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47634">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47634:SF9">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="128"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="305"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="348"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="484"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="16"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="34"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="46"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="89"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="315"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="364"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="422"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="433"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="490"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="519"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="157"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAG5087738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="716" mass="78280" checksum="95562CF26A250FA8" modified="2022-05-25" version="1">MSTKASVNRRVLAIQAKKKRYKPTKRKGAKSTGSNSQQDNTDNSSGAHCSKTSSATAARQSDQDSNGPRPFTADNGNRLEPSHSSSNETIEDDDDVYSSEEEEQEDSSDYCHGGYHPVKIGDLFLNRYHVTRKLGWGHFSTVWLCWDLQDKRFVALKVVKSASHFTETALDEIKLLKDVRDTDPNDPKRNKTVQLLTDFKISGINGLHVCMVFEVLGHNLLKLIIKSNYRGIPRNNVKRIIRQVLEGLDYLHNKCKIIHTDIKPENVLICVDETYIRKLAVVATELHSLGLKLPVSLVSTAPKKFQEPTVNSKMSKNKKKRLKKKAKRQNELLKKQMEQIEELEERSKNINNTQNGGSAGGQGDNNSGGCISETNSPTTDQDQNTESIDDNTESKESPDISDPVITSPHRGVNGIVTDLATGGSSDNMDNTLSSSASSSDNKSSLGLINQEATAGGAQIPPGDKSCGDGLSSLITATTTDAAADVNTGTSTGGNNGSSSSSGGGGGGNNGNGGGSNNSRDNSTRTVNSADNKHPKRMSVAPLDPALVDCEVEVKIADLGNACWVHKKFTEDIQTRQYRSLEVLLGAGYSTSADIWSTACMAFELATGDYLFEPHSGADYSRDEDHLAHIIELLGEIPRRIALSGKYSKAFFNKKGELKHITGLKPWGLYEVLTEKYDWSPSEAREFADFLIPMLDFDPDNRNTAAECLKHPWLQIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MH57</accession>
    <name>A0A8J2MH57_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Similar to Scyl2: SCY1-like protein 2 (Mus musculus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HICCMSTLAB_LOCUS3123</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5080868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MH57"/>
    <dbReference type="OrthoDB" id="79687at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14011">
        <property type="entry name" value="PK_SCY1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051177">
        <property type="entry name" value="CIK-Related_Protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12984:SF16">
        <property type="entry name" value="BLACK MATCH, ISOFORM H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12984">
        <property type="entry name" value="SCY1-RELATED S/T PROTEIN KINASE-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="4">
        <location>
            <begin position="26"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="728"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="274"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="774"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="799"/>
            <end position="816"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAG5080868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="860" mass="96426" checksum="51D528CE705EF28D" modified="2022-05-25" version="1">MFKFKNTQPNIVESNPIWEEFAARKQTPAATAGPEHVWRIFDAYKKSDGQDASVFVFEKRSVEKFHKPKHKETVTEILRRCARNLEDYRHPKLLQVIHPVKECAETLAFATEPVLGSLANVLAYREQAATAIPTAANPNSNYAAGQQNPHQQPPGHRPILIKEYDMVPMEIKYGLLQVITEALSFLHCSCKVIHKNVCPSSIIITKKGTWKLFGLEFIDPIPCHPWTNKISKIIQPNLDYIAPEIQLTKLCSIRSDMFSLGMVIATIYNDGRSLIQANHSNSDYIKQLDNLNENVENLLSRVPIALHEAVSRLLHKDPEARPIAKHLSLIKYFSDPSVHALQFLDVINMKDPNQKAHFYRNTLKEVLPFIPLKLWYQHIWPYLQAESKSQEVFASVLQPMLFIIQQSNTEDYEKIILPSFRELFSSPRSVQGTVVLLENLHVVFEKTPSEIINGEMLPVLYSSFESPNIQVQAAAFVAVSKVCDYIDENSLKNIVLPKLMQAFEGSTTDSRVLMNCLSRILEQLDTQQITDEVFPLLWEIKLQEPDAVLRVVNIYRLLLSNKKYGLSINLLATRVMPILLPVTVNPSLNIDQFTVLMEILQDMLTRIERNQASKLKLSMSSPERHRPLRHQFSTENMHVPPFNIPGLRIEQRKTSSAEDMVRKTSIGSMSMTASAENMTRKNSMSGSLLGGWWFGSSSSANEGGFLRVASAFPSRRLSDNTLMTPKIRIAPSCSSSPGGTPGGGLPIRRHSSTGPQERRGSNVNLSPPTGGMPATSNSVPYLLSSSMTSIRNSRRPSVSSTTSQQGSGLLQQFGTGMNQRGNWDHYYPDDDITPSTNQVAIVVTIDGSSGSSSTEQIRPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MH79</accession>
    <name>A0A8J2MH79_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">MULE transposase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS3624</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5082675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MH79"/>
    <dbReference type="OrthoDB" id="6482909at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5082675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="289" mass="33092" checksum="25A17E3D07BA775A" modified="2022-05-25" version="1" fragment="single">MANNGRKRKSYIDSLPDRVFHGFTFRQGRPLKDGARRLICSHAESHACDALGTLSATDDFSYVPKKEKHTHERDPDAEIKARFTRDLYIATKHQFRTLQIIYDEIALLHEEGAALLSFNDINRKMQAWLENRVLPEVTSIGDIKLQLNDPLFKNINLHNAGKTEIEFVQDEEGQDTAMILVDANLLSQLETTTLFIQSTDHKFEGVDNLQLTSISTKHMDHILPLVWIILSDKNEKICESILRKILTLQPTLSPTAIYSEFDSDYWRAVKAVFPNVIIKGMFLSHCKQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MHQ7</accession>
    <name>A0A8J2MHQ7_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS6362</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5092771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MHQ7"/>
    <dbReference type="OrthoDB" id="7649039at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035188245" evidence="1">
        <location>
            <begin position="21"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5092771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="146" mass="16898" checksum="A8238E9527420EB2" modified="2022-05-25" version="1">MFIKLFYLTILNGIFHSAHSSINSQLPCPRIEYVTENGTRRISDVDGFFPFVTEMMKHKMEGVYLHLYGDEGDEPSSVYYIRCDKSEIHLTLSDLAEVTNKLLMEKEAGRSLFHFAINNCPNFEGDMKQFQLKSQIQLCYFPPESI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MIY0</accession>
    <name>A0A8J2MIY0_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">MULE transposase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS5547</name>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS5735</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5090235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5090750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MIY0"/>
    <dbReference type="OrthoDB" id="90756at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018289">
        <property type="entry name" value="MULE_transposase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47160:SF10">
        <property type="entry name" value="MULE TRANSPOSASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47160">
        <property type="entry name" value="PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10551">
        <property type="entry name" value="MULE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MULE transposase" evidence="1">
        <location>
            <begin position="187"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5090235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5090750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="409" mass="48080" checksum="774C82EE8114CDF4" modified="2022-05-25" version="1">MEKLFQFRSEKNILSQFFFDGGHCYKRRDENDIYVKCLLKNNKKCYARGVLNRGAPITLLKGHNHSQNHNLKLIFDFKYELFKAVTSNLCDLRSIYDELSVKYPRGSSLLPFCRMVRVMQQWRRKICPPTPTSLGEYYLRLKLNRWKHLCKSNNSNLTVTNVYGRDGSIATVFIDPDFLENVQTTNLYIDATYKVCPTMPKNIYQFFTIMASINNSILPVAWSLMSRKSTDCYTAVIDHFKSLSQHIIVLSYMTDFEGGLRKALKLSYPNATAESCYFHFIQANMKKAKKLGLLKKLENWEDGRKFFRKLLALALLPSTDIIPTFNWLLVIRTPFYLIFKDFINYFVDYWLMTIKPDGFSVYKLKNRTNNFTEAYHRRLNKFFGLHPSLWQFTGNNLVITSIVRTLYFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MJV7</accession>
    <name>A0A8J2MJV7_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Dynein light chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HICCMSTLAB_LOCUS3018</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Acts as a non-catalytic accessory component of a dynein complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Cytoplasm</location>
            <location evidence="1 9">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the dynein light chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001117">
        <property type="protein sequence ID" value="CAG5079464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MJV7"/>
    <dbReference type="OrthoDB" id="10033309at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005868">
        <property type="term" value="C:cytoplasmic dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045505">
        <property type="term" value="F:dynein intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd21452">
        <property type="entry name" value="DLC-like_DYNLL1_DYNLL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.740.10:FF:000001">
        <property type="entry name" value="Dynein light chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.740.10">
        <property type="entry name" value="Protein Inhibitor Of Neuronal Nitric Oxide Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037177">
        <property type="entry name" value="DLC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019763">
        <property type="entry name" value="Dynein_light_1/2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001372">
        <property type="entry name" value="Dynein_light_chain_typ-1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11886">
        <property type="entry name" value="DYNEIN LIGHT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11886:SF35">
        <property type="entry name" value="DYNEIN LIGHT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01221">
        <property type="entry name" value="Dynein_light"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01375">
        <property type="entry name" value="Dynein_light"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54648">
        <property type="entry name" value="DLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01239">
        <property type="entry name" value="DYNEIN_LIGHT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 9" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5 9" id="KW-0243">Dynein</keyword>
    <keyword evidence="4 9" id="KW-0493">Microtubule</keyword>
    <keyword evidence="6 9" id="KW-0505">Motor protein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00058182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAG5079464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="115" mass="13424" checksum="6E2CF9974923048A" modified="2022-05-25" version="1">MKQNMPVFDVHAIVKIDRVPLKRPHNMSDRKAVIKNADMSEEMQQDAVDCATQALEKYNIEKDIAAFIKKEFDKKYNPTWHCIVGRNFGSYVTHETRHFIYFYLGQVAILLFKSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MKY4</accession>
    <name>A0A8J2MKY4_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cc_odve66_30</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS3733</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5083109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MKY4"/>
    <dbReference type="OrthoDB" id="10367527at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5083109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="287" mass="32632" checksum="A3EAE65E382300BC" modified="2022-05-25" version="1">MDKIRIISITAVTGIVAVGLYFAFRRSFGETNEPLDDDIPLVSSLPGTETSSENSLKNQRLMAVNTVIKEFAKWKITTFDIKTYSSTVSLATDPKTTDLQVIHSVCTEGKPCNLEDGLLYTLNEAAVDLLAYYVRHNEKKHLDTAERLVKIIFGNKLKDYDPTRTKLFNLPTLINNIAILPILFEYIADSTYDNTRNMCHEFISKVLPNFHAFDKTTFNSEILMFNSIRMLSNNLFNTWNFNEDSADKNIQILIDSAVQSGLKSYRIIDYDSTLRGRLYKALMTGNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2ML21</accession>
    <name>A0A8J2ML21_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS6652</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5093183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2ML21"/>
    <dbReference type="OrthoDB" id="7615572at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5093183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="154" mass="17537" checksum="B9EEE970D1BF721B" modified="2022-05-25" version="1" fragment="single">LGSHHERFKRQQQGVVGGGVDPNLGVQLNDTRVIWRDVQSAFNRRIRTGMVVNLLHIDLKNFLLDAKELIINQLQSALQVDASLKVNVILTAKFWKPGGEDQIIETKTFPTKNEEDSDERTIHLLMVEVPSEDMGMDIDDMNIDDIENRIANFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2ML40</accession>
    <name>A0A8J2ML40_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF4773 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS3824</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5083385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2ML40"/>
    <dbReference type="OrthoDB" id="5952164at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031941">
        <property type="entry name" value="DUF4773"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36299">
        <property type="entry name" value="AGAP008005-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36299:SF2">
        <property type="entry name" value="DUF4773 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15998">
        <property type="entry name" value="DUF4773"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035304223" description="DUF4773 domain-containing protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4773" evidence="2">
        <location>
            <begin position="28"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF15998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5083385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="154" mass="17757" checksum="E4A474B9C8EE9A52" modified="2022-05-25" version="1">MNYYILLLIFFSINSINAHFNENQNNGCHCVNYNCGCCEKLNLPEIHGIVCSNFTYLSDDYGISLTITYNNYTLYNETISARNPPPICVGIPEFEKISAEICITFYDLTFKMHHFHCCSNLRVAIYHVIHKEINLGCFDIPSVRKKNYPNVIVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MMB2</accession>
    <name>A0A8J2MMB2_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Similar to Src64B: Tyrosine-protein kinase Src64B (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HICCMSTLAB_LOCUS7879</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5095780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MMB2"/>
    <dbReference type="OrthoDB" id="28230at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050198">
        <property type="entry name" value="Non-receptor_tyrosine_kinases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24418">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Serine-threonine/tyrosine-protein kinase catalytic" evidence="3">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG5095780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="70" mass="8317" checksum="1CD2FB050A744339" modified="2022-05-25" version="1">MHGREVIEQVDKGYRMPKPANQPLPDSIYRLMLQCWDACPEKRPTFEFLNHYFESFNVTSEIPYLEPPTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MN31</accession>
    <name>A0A8J2MN31_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS6969</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5093633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MN31"/>
    <dbReference type="OrthoDB" id="6606882at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="52"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="84"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="135"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="183"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5093633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="203" mass="21904" checksum="E60F6248E6975EFF" modified="2022-05-25" version="1">MILLIAVIVYQLSTNMATVFESPFLSNRLRQIEERYEEPATFGRCDCTSYSYLALSVVLFTIGTAVTILSLGDAVDGQIFSNLGHMWLVGPIFICSGLMVAVKCILYLRRKSVIQMIIHQRQLFRRLQELASAQGVGGSGAGTPGPPPYDSIAQGQGPSELPPPTYAEAVALLHQSEIHGAKFSSDTQADSGLLSVGTTRAKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MNT8</accession>
    <name>A0A8J2MNT8_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS7438</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5094896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MNT8"/>
    <dbReference type="OrthoDB" id="413313at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16021">
        <property type="entry name" value="ALP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.720.10:FF:000017">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004245">
        <property type="entry name" value="DUF229"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10974">
        <property type="entry name" value="FI08016P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10974:SF1">
        <property type="entry name" value="FI08016P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02995">
        <property type="entry name" value="DUF229"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="58"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="254"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5094896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="734" mass="85514" checksum="C96905F973CA0548" modified="2022-05-25" version="1" fragment="single">NCRKYLKKCARNHHQRIDSVRSRIKYVTFERKMSHQRYMNIKHEKNFKCNVGLKVRTWYLGILGFLIASLIIINNFITNQFNSSIDHFANVSIQDNFIEREQRKISIVTNTVLGFIVHKQGCQIAELDPFNEFAKHFMETENPLECEFGNQLPLVESNDTAIFINPDAHNQYYNETEVVADCCWRIFERKKNQDNFVKYDPLCHKFNSSTTITAEFIKVECFKNNNNNNNSKQIYRDYHFFVPRKPIVEERCHAAEKKRKEERKKHETEKDDNNNDNHLSILILGLDSVSRMNFHRMMPKTIETLKSMGAIEMMGYNKIGDNTYPNLVSVLSGLSEKEFRSNCWNNSKLPFDKCPLIWKNFSKSGYRTIFAEDACAMTTFNYLKPGFRNQPTDYYFRPYCLAAESDIGNTHKLNADLCIGTRKTFDNLLNYTKKVVREFNGDRYFAFFWEASLTHDFFNYPQLGDLPYSESISYLHNQGFLNNTVLIVMSDHGMRWGEFRQTYQGRIEGSLPLMFIILPEWWKKKFPLAVNNLKQNTVSLTTPYDFHETLMDFLHPENLTDQVILSRINKNMPNDKNNSSFPRGISWFLTIPDKRNCSMAGIPGHWCMCHKSTNISHDDSAVKNAADFIINELNTMVNKKYPQCSLLKLSKVIDAKVWSAHGVEKDKDEERSVPWIDYTISIKTIPSNAIFEATVRHDNTGNSTIVGSIGRLNSYGKQSTCVDDFNMRLYCYCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MP00</accession>
    <name>A0A8J2MP00_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">1-acylglycerol-3-phosphate O-acyltransferase</fullName>
            <ecNumber evidence="2">2.3.1.51</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HICCMSTLAB_LOCUS7530</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="pathway">
        <text evidence="1">Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol 3-phosphate: step 2/3.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.51" evidence="2"/>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5095080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MP00"/>
    <dbReference type="OrthoDB" id="202234at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003841">
        <property type="term" value="F:1-acylglycerol-3-phosphate O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006654">
        <property type="term" value="P:phosphatidic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07989">
        <property type="entry name" value="LPLAT_AGPAT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10434">
        <property type="entry name" value="1-ACYL-SN-GLYCEROL-3-PHOSPHATE ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10434:SF11">
        <property type="entry name" value="1-ACYL-SN-GLYCEROL-3-PHOSPHATE ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69593">
        <property type="entry name" value="Glycerol-3-phosphate (1)-acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="5"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="33"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="domain" description="Phospholipid/glycerol acyltransferase" evidence="6">
        <location>
            <begin position="93"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAG5095080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="239" mass="27362" checksum="C98225FF17C625E6" modified="2022-05-25" version="1">MTPSYLEIILVGFILILPFLYETSSTFRYYFKFLLYYGIVMANSLILIPIMVFRPGNVKNLLLASSICHHVSNLLGLKWELRNRENLEKEQACIVVANHQSSLDILGMFEMWPVMDKCTVVAKKELFYAWPFGLAAWLCEGTRHNTGEIHPFKKGAFHVAVNSQLPILPVVFSSYYFLSKKDKRFDPGRVIITTLPPILTKGLGPEDIEALMEKTRNSMTQVFYSSSREVQQSLNSCKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MP16</accession>
    <name>A0A8J2MP16_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS7560</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5095140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MP16"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5095140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="109" mass="12303" checksum="E3399C0C13D16D6B" modified="2022-05-25" version="1">MLATRTSTAIFSMGTPAPPSIGESWQLSPESGPQKSSTADHFCHCLHDDAPPVVLRLKPEAQTTEHCCLYSYQRNLILLPALWSLLFLFRRIGCWYCLTWLLGECFCLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MPI9</accession>
    <name>A0A8J2MPI9_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Similar to Tmem30a: Cell cycle control protein 50A (Mus musculus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HICCMSTLAB_LOCUS4584</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the CDC50/LEM3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5087705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MPI9"/>
    <dbReference type="OrthoDB" id="340608at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005045">
        <property type="entry name" value="CDC50/LEM3_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10926:SF0">
        <property type="entry name" value="CDC50, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10926">
        <property type="entry name" value="CELL CYCLE CONTROL PROTEIN 50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03381">
        <property type="entry name" value="CDC50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015840">
        <property type="entry name" value="DUF284_TM_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="33"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="319"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR015840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG5087705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="362" mass="40817" checksum="143D1200FD847F8C" modified="2022-05-25" version="1">MTSPADNTPVSAKIKKPSDSAFKQQRLPAWQPILTAGTVLPTFFVIGIAFIPVGIGLLHFSNEVQEKVVDYTDCVSIDSNNGTKCSDVIANYPRKPCFCHVNFTLESDFPSKVYMYYGLTNFYQNHRRYVKSRDDFQLLGTLSKEVNSDCEPFAYVEENGKKNPIAPCGAIANSLFSDELSIIALDINNMPVPLIRTGIAWPSDKNIKFKNPPGNLEQAFAEFEKPRNWSKKVWQLDPDDPTNNGFQNEDLIVWMRTAALPNFRKLYRRINHTDLHFKSGLRQGNYQLQVNYSYYVSSFHGKKKMILSTTSLLGGKNPFLGIAYIVVGCVCLVLGIALLIIHIKCSKSTNEIINVNQHTPYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MQ68</accession>
    <name>A0A8J2MQ68_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similar to Vps26c: Vacuolar protein sorting-associated protein 26C (Mus musculus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS10240</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the VPS26 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5101167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MQ68"/>
    <dbReference type="OrthoDB" id="10263384at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.640">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014752">
        <property type="entry name" value="Arrestin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028934">
        <property type="entry name" value="Vps26-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12233">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING 26 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03643">
        <property type="entry name" value="Vps26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5101167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="119" mass="13062" checksum="7FCF787F876FF39D" modified="2022-05-25" version="1">MVEDRTPIGKEIKPQEPVRPVTFKIVPESLQNIRDKASVPEFIISGQIDKVICKLSEPLTGQVIIEETAALIKSIELQLVRVETCGCAEGYSRDATEIQNIQIGEGNVFTCAFGGLLTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MQZ3</accession>
    <name>A0A8J2MQZ3_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Similar to Rpn2: 26S proteasome non-ATPase regulatory subunit 1 (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HICCMSTLAB_LOCUS11131</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5102682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MQZ3"/>
    <dbReference type="OrthoDB" id="261572at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008540">
        <property type="term" value="C:proteasome regulatory particle, base subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034515">
        <property type="term" value="C:proteasome storage granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002015">
        <property type="entry name" value="Proteasome/cyclosome_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040623">
        <property type="entry name" value="RPN2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10943">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10943:SF2">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01851">
        <property type="entry name" value="PC_rep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18004">
        <property type="entry name" value="RPN2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5" id="KW-0647">Proteasome</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="26S proteasome regulatory subunit RPN2 C-terminal" evidence="4">
        <location>
            <begin position="133"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="185"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="326"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="189"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="221"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="233"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="340"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF18004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAG5102682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="354" mass="39408" checksum="DB345FFDA30BF5FC" modified="2022-05-25" version="1" fragment="single">MALGIACAGTGLKEAIALLDPMTNDPVNFVRQGALIASAMILIQQTEATCPRVKDFRALYAKVVVDKHEDVMAKFGAILAQGIIDAGGRNVTVSLQSRTGHTNMLAVVGTLVFTQYWYWFPLTHALALAFTPTCVIGLNAQLKMPKFEIRSNARPSVYAYPAPLEEKKREEREKVQTAVLSIAARARRRESERRARHSHEMMEVDPPVVESKEADSKDTPSTSTSASSSAVTLKDDKKKEKDEKEKDKDKKDDKDKDPKDAKKAKDDEKKEPEPSFEILQNPARILRQQLKVIQLVEGSQYAPVKDIQIGGIVMLKHIKPESEEELVEPVAAFGPKPDEEKEADPPEPFEYTED</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MQZ8</accession>
    <name>A0A8J2MQZ8_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Mitochondrial (Bos taurus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HICCMSTLAB_LOCUS11766</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GcvT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5103951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MQZ8"/>
    <dbReference type="OrthoDB" id="429143at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1400:FF:000003">
        <property type="entry name" value="Pyruvate dehydrogenase phosphatase regulatory subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.110:FF:000004">
        <property type="entry name" value="Pyruvate dehydrogenase phosphatase regulatory subunit, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.110">
        <property type="entry name" value="Aminomethyltransferase beta-barrel domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1400">
        <property type="entry name" value="Aminomethyltransferase beta-barrel domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.120">
        <property type="entry name" value="Probable tRNA modification gtpase trme, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032503">
        <property type="entry name" value="FAO_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028896">
        <property type="entry name" value="GcvT/YgfZ/DmdA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029043">
        <property type="entry name" value="GcvT/YgfZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013977">
        <property type="entry name" value="GcvT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006222">
        <property type="entry name" value="GCVT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027266">
        <property type="entry name" value="TrmE/GcvT-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43757">
        <property type="entry name" value="AMINOMETHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43757:SF15">
        <property type="entry name" value="PYRUVATE DEHYDROGENASE PHOSPHATASE REGULATORY SUBUNIT, MITOCHONDRIAL-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16350">
        <property type="entry name" value="FAO_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01571">
        <property type="entry name" value="GCV_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08669">
        <property type="entry name" value="GCV_T_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101790">
        <property type="entry name" value="Aminomethyltransferase beta-barrel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103025">
        <property type="entry name" value="Folate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="3">
        <location>
            <begin position="53"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="3">
        <location>
            <begin position="244"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="domain" description="FAD dependent oxidoreductase central" evidence="6">
        <location>
            <begin position="370"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="domain" description="GCVT N-terminal" evidence="4">
        <location>
            <begin position="428"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="domain" description="Aminomethyltransferase C-terminal" evidence="5">
        <location>
            <begin position="739"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="833"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="837"/>
            <end position="854"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF16350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAG5103951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="854" mass="95826" checksum="0EAAD9A8B2017530" modified="2022-05-25" version="1">MWPKTPSAFKKLKDYHWKKLLTNQQELSGWRTMAGGSNEPPKGHNLSLPESKHVVICGGGVMGAAVAYHLAAAGLGPQTILLEGSRIGEGTTWHSSGLVGAFKPSLFQVKLTQDSIALYKDLEARGLSTGWKQCGSLSVARTRDRMTSFRRMKAQAVSRDIECELITPAEAQKLCPLLRVDDLVGGIWIPGDGVADPYLTCLTLIEEAQKNGVEIYENCRITKVLSNQGKVSKVETTRGLDPMTPVVRDLDGSVYFRENGGRILAGGFESNAKPAFEDGKIPENISERILPEDWDHFHVLLEEMLQRIPSMGDAELERLCNCPEAFSPDCKWIVGEAPELRNYYVAAGMKTIGVSAAGGVGRATAELIINGSTSFDMYELEVSRFLGLHNNRTFLRDRVREVPSTHYALQYPHHEYKTGRNLRMSPIYPKLKEAGAVFGQVMGYERPSWFEPASDDDFDPIDESRRYKIAYTNTFGKPPWFDAVANEYAACRETIGLSDYSSFTKIDLWSSGTEVVDLLQYLCSNDVDVPIGGIIHTGMQNHRGGYENDCSLARISHNHYMMIAPTIQQTRCKHWIRRHLPADGSVAVSDVTSAYTAICIMGSATRQLLAELTDTDLSPKNFPFFTFKELDVGLATGIRTMNLTHTGELGYVLYIPNEFALHVYTRLIEAGEKYGMKHAGYYATRALRVEKFYAFWGQDLDTFTTPLECGRAWRVKFDKDIDFIGRDALMKQRDTGVERKYVQLLLIDHDPDIDIWSWGGEPIYRNGQYCGMTTTTGYGYTFKSQVCLGFIQNIDDKGRNQVVTNEYVLSGDYEVDVAGIRYRAKCHLHSPNLPTKFPDKERDSYHATRDQVTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MRA5</accession>
    <name>A0A8J2MRA5_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS11011</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5102430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MRA5"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5102430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="93" mass="10493" checksum="E2BDCE18C20CE219" modified="2022-05-25" version="1" fragment="single">MIVQEPVQFNLSRALMTLSKRYCKILVCADIYIINPGNNVSKLACVYVLITELKTCCAAVITAKKLIKKKLDLPADVYILLANVFFELITRLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MRL7</accession>
    <name>A0A8J2MRL7_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Similar to nclb: Periodic tryptophan protein 1 homolog (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HICCMSTLAB_LOCUS11767</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5103953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MRL7"/>
    <dbReference type="OrthoDB" id="270624at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044285">
        <property type="entry name" value="PWP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14091">
        <property type="entry name" value="PERIODIC TRYPTOPHAN PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14091:SF0">
        <property type="entry name" value="PERIODIC TRYPTOPHAN PROTEIN 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 4" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="136"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="264"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="358"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="366"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAG5103953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="385" mass="43375" checksum="7EE6B78B2696C107" modified="2022-05-25" version="1">MNVIPCCTWVKRGVSAAVPDKVQLTAEELAGIIKKTESDLAEFEANSDDDSDKEEAGCIYNEREGSFYCHHDIFLPSFPLCFEWLSFDPSDAKPGNFVAIGNMTSVIEVWDLDIVDCLEPIFKLGCKPSKKHNRKRVGHKDAVLDLAWNVQLPHILASGSVDKTVLLWDIEKGVPDTKLDQFTEKVGALQWHPKKSYMLLAGSEDKTAKLFDCRTSDTFKTWEATGEVERVLWNHFDPNYFFLSTKNGIIECIDIRQGQHLWEVKGHEKEITGLSLSSSCPGFLVTSSEDGVIKVWDALSPQLLEPVWETETNLGAIQCLHLSPNSPFTIAVGGDHKSHNFKVWDLTENSQVNERFRSRRLVEPIQNEESDAGNPEDTEEMETDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MSA4</accession>
    <name>A0A8J2MSA4_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Similar to Acyl-CoA Delta(11) desaturase (Choristoneura rosaceana)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HICCMSTLAB_LOCUS12627</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="11">The histidine box domains are involved in binding the catalytic metal ions.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the fatty acid desaturase type 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5107194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MSA4"/>
    <dbReference type="OrthoDB" id="10260134at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004768">
        <property type="term" value="F:stearoyl-CoA 9-desaturase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006636">
        <property type="term" value="P:unsaturated fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03505">
        <property type="entry name" value="Delta9-FADS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015876">
        <property type="entry name" value="Acyl-CoA_DS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11351">
        <property type="entry name" value="ACYL-COA DESATURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11351:SF26">
        <property type="entry name" value="FATTY ACID DESATURASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00075">
        <property type="entry name" value="FACDDSATRASE"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="3 11" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="19"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="45"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="76"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="161"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="185"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAG5107194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="324" mass="37813" checksum="CE0B7DD5B814FA59" modified="2022-05-25" version="1">MSEPEKAESEKGEMQWHIILWYIHLYALGLYGVYLLLFYTSWMTVFFTILITYIGGLGVTIGAHRLWAHQTYEAVWYIRLFLMLAHTLAGVGSIYDWVLAHRIHHKYYGTEKDPFNPNKGFLHCHLIANAMTNPPNYEQTAKAIDMRDIHLDGYVWFQNKFYWPLFLIIGILLPINAPAEYWGESIANSVLVLGFFRFAVLSNMAWLIHSGTLIWGLKPHEKYPPDDNMVFLINKSYWLNYHYILPWDWKCSEYGSYDKGWATNTIKILNIIGLVNRMKTASSESIRDALFKASTSKKPFNEIMDEVKEIASVEADKINLRYHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MSE0</accession>
    <name>A0A8J2MSE0_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS12552</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5107033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MSE0"/>
    <dbReference type="OrthoDB" id="10055432at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.90.10">
        <property type="entry name" value="Cystine-knot cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029034">
        <property type="entry name" value="Cystine-knot_cytokine"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41153">
        <property type="entry name" value="RE41427P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41153:SF2">
        <property type="entry name" value="RE41427P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57501">
        <property type="entry name" value="Cystine-knot cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035248900" evidence="1">
        <location>
            <begin position="23"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5107033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="235" mass="25759" checksum="D42DD0314521B781" modified="2022-05-25" version="1" fragment="single">LSFFFLQIQSLLRFFLFALVCGCYTQASKKCSAGGLDLKYVRGDALIDSADCLGPNNAPYPSAAIEKSLKSFWGGSSRTGRAYHQNRVADPELTRQKLLHNYKLSHGDYTVSSVRNGRSFSSKETCGSPGRLCKTRYNTTAPMYGVSLTSGQPVTIVQKFPDLLQQVVFEVCESKECDVVHGECTQTYVPYLFLVIPLGPVTLTGQDYVLVESGCVCKPRNSLTTSSEAPLVPNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MSG8</accession>
    <name>A0A8J2MSG8_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Similar to tamo: Protein tamozhennic (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HICCMSTLAB_LOCUS6515</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5093004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MSG8"/>
    <dbReference type="OrthoDB" id="9837000at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.2190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.380">
        <property type="entry name" value="Zn-finger domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048839">
        <property type="entry name" value="SPATA2_PUB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001876">
        <property type="entry name" value="Znf_RanBP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036443">
        <property type="entry name" value="Znf_RanBP2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15326:SF2">
        <property type="entry name" value="PROTEIN TAMOZHENNIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15326">
        <property type="entry name" value="SPERMATOGENESIS-ASSOCIATED PROTEIN 2/TAMOZHENNIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21388">
        <property type="entry name" value="SPATA2_PUB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00547">
        <property type="entry name" value="ZnF_RBZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90209">
        <property type="entry name" value="Ran binding protein zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01358">
        <property type="entry name" value="ZF_RANBP2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50199">
        <property type="entry name" value="ZF_RANBP2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RanBP2-type" evidence="6">
        <location>
            <begin position="519"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="364"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="431"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="389"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="431"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="459"/>
            <end position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAG5093004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="590" mass="66854" checksum="F8D0F67C44B14497" modified="2022-05-25" version="1">MMAFDILDRPGAAIIDKLEEISINVEKSHLAYLQMDESEEKLALRHKLEGFIKEYLHLVPHENKYVFEQTAHILHQSAAILPDFSGYRACSAWIAISLYAANLLAQPWRKEYRTLRTYSGYYKHEIETNLIGAELMFELMGYKPTLHERGVMTLEGPIDPDRVSFVSRDAIVAFVECQIMKQIWENVSQTFTVSWLEVLEFREKHVGTPENAIRALNHRFWERCQQRRKNYDLHYAQPAIINSPINEYQTGIKYPINYRPDVVPVPGTRSSVPGTAVLGTGIRSTVPGTAVLGTGTRNTVPGTAVLGTGIQRVPMLPLAANYVPDNYRYEDLRYFESDLNNHYNQVYGVPTYAHAPLIEFDGSYDKRSHRRSKSSTTAIKPPDQFDGGNKSSPIKTSMSLDSATASNDSWDFVYRSLKDLGYSKDVAEREDVLRNERQSKRRESSDKFEERRRSRSSKNANYNGNSNPRIDKAPLIDLGATYNYDSEGSDLMVEVKGRNKRDKDQVCDLVKNMKIDGAAEATWSCLTCTFFNAAGKEICEMCGKSRRKGNEDIPLASGGKVCPKCTLVNEKEAFVCEACQFNLKDSPTYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MSX3</accession>
    <name>A0A8J2MSX3_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="21">Similar to ARA1: Acetylcholine receptor subunit alpha-like (Manduca sexta)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">HICCMSTLAB_LOCUS12192</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="1">After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="17">Postsynaptic cell membrane</location>
            <topology evidence="17">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5106302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MSX3"/>
    <dbReference type="OrthoDB" id="5975154at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045211">
        <property type="term" value="C:postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022848">
        <property type="term" value="F:acetylcholine-gated monoatomic cation-selective channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007271">
        <property type="term" value="P:synaptic transmission, cholinergic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd19031">
        <property type="entry name" value="LGIC_ECD_nAChR_proto_alpha-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19064">
        <property type="entry name" value="LGIC_TM_nAChR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.170.10:FF:000013">
        <property type="entry name" value="Acetylcholine receptor subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.390:FF:000012">
        <property type="entry name" value="Acetylcholine receptor subunit alpha-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.390">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006202">
        <property type="entry name" value="Neur_chan_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036719">
        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038050">
        <property type="entry name" value="Neuro_actylchol_rec"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006029">
        <property type="entry name" value="Neurotrans-gated_channel_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018000">
        <property type="entry name" value="Neurotransmitter_ion_chnl_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002394">
        <property type="entry name" value="Nicotinic_acetylcholine_rcpt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00860">
        <property type="entry name" value="LIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18945">
        <property type="entry name" value="NEUROTRANSMITTER GATED ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02931">
        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02932">
        <property type="entry name" value="Neur_chan_memb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00254">
        <property type="entry name" value="NICOTINICR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00252">
        <property type="entry name" value="NRIONCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90112">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane pore"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00236">
        <property type="entry name" value="NEUROTR_ION_CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="16 18" id="KW-0407">Ion channel</keyword>
    <keyword evidence="9 18" id="KW-0406">Ion transport</keyword>
    <keyword evidence="15" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="10 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-0628">Postsynaptic cell membrane</keyword>
    <keyword evidence="12 21" id="KW-0675">Receptor</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 18" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0770">Synapse</keyword>
    <keyword evidence="5 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 18" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 18" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="18">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035338076" evidence="18">
        <location>
            <begin position="21"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="230"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="265"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="295"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel ligand-binding" evidence="19">
        <location>
            <begin position="25"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel transmembrane" evidence="20">
        <location>
            <begin position="236"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="21">
        <location>
            <position position="514"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00034104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU000687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF02931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF02932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="CAG5106302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="514" mass="59017" checksum="AE4D291E4A01A7ED" modified="2022-05-25" version="1" fragment="single">MKSLVGIMWIVLVLISGCSGNPDAKRLYDDLLSNYNKLVRPVVNVTDALTVKIKLKLSQLIDVNLKNQIMTTNLWVEQSWYDYKLQWDPKEYGGVEMLHVPSDHIWRPDIVLYNNADGNFEVTLATKATLNYTGRVDWKPPAIYKSSCEIDVEYFPFDEQTCVMKFGSWTYDGFQVDLRHIDEVHGNNVVDIGVDLSEFYTSVENEKYYTCCDEPYLDITFNITMRRKTLFYTVNLIIPCMGISFLTVLVFYLPSDSGEKVSLSISILLSLTVFFLLLAEIIPPTSLVVPLLGKFVLFTMILDTFSICVTVVVLNVHFRSPQTHVMAPWVRRVFIHVLPRLLVMRRYDLRPQFQIDRRSFDRQRVMVRTCNGLEVRDPTRFAEDPGAEFVEPPMLFPSVDSRDELNPRELEAVNLGSACQIHGSPASIPPPPQLPTEDSVDALCKTLNNWHHSPTLYDDRVPIDVRLSEIASTTAKPHIVFRKTNKVIRSNKITKSLNKFKLVRELMYQTKTDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MU44</accession>
    <name>A0A8J2MU44_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Similar to Marchf8: E3 ubiquitin-protein ligase MARCHF8 (Mus musculus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HICCMSTLAB_LOCUS13161</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Endosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Lysosome membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5108285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MU44"/>
    <dbReference type="OrthoDB" id="264354at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002376">
        <property type="term" value="P:immune system process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011016">
        <property type="entry name" value="Znf_RING-CH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45981">
        <property type="entry name" value="LD02310P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12906">
        <property type="entry name" value="RINGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00744">
        <property type="entry name" value="RINGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51292">
        <property type="entry name" value="ZF_RING_CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0391">Immunity</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="149"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="191"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="RING-CH-type" evidence="10">
        <location>
            <begin position="66"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="14"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAG5108285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="310" mass="34617" checksum="1A5CB769D31802BB" modified="2022-05-25" version="1">MNLNDSKVMPVHQINVNPPDWQSPQSLDPSNNTSPSGGGEWSPKEPTYATVVTVLPNHCHSSISTLSSSNHDICRICHCEGDIGAPLLAPCYCSGSLRYVHQACLQQWIKASDTRACELCKFSFIMHAKTKPFSEWEKLEMSAPEIRKLWCAVAFHAVAALCVAWSLYVLVERSVEEARKGFVDWPFWTKLIVVVIGSTGGLVFMYIQCKAYIELCRRWRAFNRVIFIQNAPEKVVLPPSPTDSLREVTLPLKDPTASLPELNRSLLPRTLDPSCASETVKPEVASAAQRHDAQLKLYVFDKLSSSEDNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MU79</accession>
    <name>A0A8J2MU79_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Similar to IntS8: Integrator complex subunit 8 (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HICCMSTLAB_LOCUS13251</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the Integrator subunit 8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5108466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MU79"/>
    <dbReference type="OrthoDB" id="64340at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032039">
        <property type="term" value="C:integrator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034472">
        <property type="term" value="P:snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038751">
        <property type="entry name" value="INTS8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057980">
        <property type="entry name" value="TPR_INTS8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13350">
        <property type="entry name" value="INTEGRATOR COMPLEX SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13350:SF1">
        <property type="entry name" value="INTEGRATOR COMPLEX SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25756">
        <property type="entry name" value="TPR_INTS8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="INTS8 TPR repeats" evidence="7">
        <location>
            <begin position="510"/>
            <end position="1021"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="746"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="753"/>
            <end position="767"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF25756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG5108466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="1023" mass="117333" checksum="B5FABC6809E4FB77" modified="2022-05-25" version="1">MMDVDLLRPGTVPISPDTILWFEFLLNPSLLKKHISKNLPDPSPTDLMIKFMSINSDSRDTEVKIIDFESSESKISNNKKYSHKSVALKILSLKIGAYFKWDLDILEIKLPLPMQLTFLQDLFYITGDFIIELPGRPEFDIATVSDQFLFTLVLYHRWHIRATVNKALNNKQSKPQFIHIPGIQEPTYVAPALVDDIMRKIEANVQHSVQVLNAVIQLTEIKPKMLTFDTFQILTEDSSEIKQNWENMQDISVEEFKCQIHYDLATIYLLREEYDIAKYHITQARDLFNNLTSLKTKMSYCRVQKDVLDGYCRATNVAIVGVELSLTQQLHNSVKNNYAGILDILKADNIAREIPMIYRDNLELDIEGGVANNKIVVPRDLLLNVQCLNLVKKILDNVIVQGNYITELKRSKSVSLDILFPAIDSVLVSASTTDKQRIARYLLYLITMTDTIELSRRILANKSYKSLFDGEQLEEIRTQGAPEVTELPALLLNNDWGVSLTTYNQSKKFHIFELERQLIHSYDPVEIRDLLIKLDRQSSMNPPSRAKSRWEIPIPLQSVVSSLPHGLYQDYTFILLAKSRELTSAKNLKDAKALLNAIEDEIQVHIATQNPNLINLSYKLSKMISWELILVEILQYYNSWNANLTVNSTVEDTNLLELVDKCKQCLANVRETDQAIPRQEIIEYCVVFLLNMAEWDYFCGMDKRWNQCDFAAAISSVCQEIVKQKGTRKFPREAWDLLLVTFGPPKDLPQKRSSTSGNSGSSTTISIGGSGGTKDIMNNTITSTLLRLREPTALAVAISLLARIHNVLRDESSLELYTQYLTLWPASISNANSYNIRMISEFLLHLLTQALKCYPTNVHFLRAMGDLNFILTYYESAMKYYLEAIMVESNLFSQRVPGHLQPMYWRMIKCCAHLQCYTQATVLCQFLEEINYSLAFKMASSDQKSCASTDAMDAYYHCIWDTTILEFLIHLHSKRGEHHRKQLAIKVIGMLELNSNNNDEIQREAANIRKARFFRALAKQYVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-10-16" modified="2023-09-13" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>S6D4U5</accession>
    <name>S6D4U5_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cc_crp.2_18.5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">crp2</name>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS6224</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Philos. Trans. R. Soc. Lond., B, Biol. Sci." volume="368" first="20130047" last="20130047">
            <title>Functional endogenous viral elements in the genome of the parasitoid wasp Cotesia congregata: insights into the evolutionary dynamics of bracoviruses.</title>
            <authorList>
                <person name="Bezier A."/>
                <person name="Louis F."/>
                <person name="Jancek S."/>
                <person name="Periquet G."/>
                <person name="Theze J."/>
                <person name="Gyapay G."/>
                <person name="Musset K."/>
                <person name="Lesobre J."/>
                <person name="Lenoble P."/>
                <person name="Dupuy C."/>
                <person name="Gundersen-Rindal D."/>
                <person name="Herniou E.A.Drezen.J.M."/>
            </authorList>
            <dbReference type="PubMed" id="23938757"/>
            <dbReference type="DOI" id="10.1098/rstb.2013.0047"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5092555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="HF586473">
        <property type="protein sequence ID" value="CCQ71275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S6D4U5"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012641">
        <property type="entry name" value="Polydnavirus_Cys-rich"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08008">
        <property type="entry name" value="Viral_cys_rich"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57059">
        <property type="entry name" value="omega toxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cysteine rich" evidence="1">
        <location>
            <begin position="30"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5092555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCQ71275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="91" mass="10411" checksum="10AF9F52C574E7FC" modified="2013-10-16" version="1">MKTTEFVFDGVLEDFCNPQCSSDPNRISYCRGCRTTCLNSKLPCCKLTYQNSYLRLGEVPTTCFKFGKGICQVNQSIKNFNEYSKLIEQVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2E0I3</accession>
    <name>A0A8J2E0I3_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ubiquitin-like protease family profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HICCMSTLAB_LOCUS217</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C48 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001074">
        <property type="protein sequence ID" value="CAG5073086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2E0I3"/>
    <dbReference type="OrthoDB" id="7695773at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008234">
        <property type="term" value="F:cysteine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd20805">
        <property type="entry name" value="C1_DGK_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.395.10">
        <property type="entry name" value="Adenoviral Proteinase, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003653">
        <property type="entry name" value="Peptidase_C48_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02902">
        <property type="entry name" value="Peptidase_C48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like protease family profile" evidence="4">
        <location>
            <begin position="346"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAG5073086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="551" mass="65252" checksum="DD0D003B817765EE" modified="2022-05-25" version="1">MAKLLENFEVPQENDETEMTWEEFKRLFKKNPTIYAKSPFYRRYYLLVEGKKDQMRSDATLKITNGLYFPQFIHYLLTTFMAYCPLWTAMMMDLLDREISRISNNYAESHMRTYKYWVLKNEKRWPIGKVCRKLQENNENLVKENILSKCELSKKLKGTQYDLYRKITENSLDGLLWNRKIESDNNEEKKVRKRKIRHMDGKKILKLTEIPEETEKISTPQEKVKDTKKNKQQKKFAANDLSIENSELHKLLLLKNGLVNDVNYYANTKSLIIVIAYYYPTTENFILKKEITMNGKQLRNLLYRRGSVDAETIDIFAAMNADKSTNVFYQSAEVASVVIKSKSKRDSNEQVHEKYYTKNNTSCGTILIPYYEQEHWILLVVSETEKSIEILDPYNRVKNPTKITNAVTSYINKCNRQSNKKSMIAANWIVKIPRDRSLQKLTDKFNSAVYVMYYAQCIGQNREMNETLDPEKYRETIIHFIMEHSLGLENKCLYCFRGIDTEKHIACIMCHRQVHNKCRRLDGMDTEDEERVEYYEPPKKKNWVVPEVLEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2E1P6</accession>
    <name>A0A8J2E1P6_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS927</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001114">
        <property type="protein sequence ID" value="CAG5074155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2E1P6"/>
    <dbReference type="OrthoDB" id="6049566at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5074155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="265" mass="30355" checksum="76FD7683B814B344" modified="2022-05-25" version="1">MPPPVTIPPTAFISVPLGLAGLLIVLLFVTANGKPAAPMAVHKQQFTSTPKWINPCGEAAENPDGSIYIEQMKDEQLLGTIILRARNALDHAKRFCDHFSKESLGLNFESMQASWNNRQYHWLPGPLEIPKQLGTTLSEDYLSKLEVRMIDSALLNAYEYMQKYAVGLEQITYDQKEEQLNFQKEFVETEHNLRSVLCELQVAMMERGVPQRGDVSRDIMPDMFRQVESITSRNTRDWIIFRDYMNGLEYVVQVFEHLKNNLESS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2E5Z4</accession>
    <name>A0A8J2E5Z4_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Kelch-like protein diablo</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HICCMSTLAB_LOCUS1065</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="4">Probable substrate-specific adapter of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. May have a role in synapse differentiation and growth.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001116">
        <property type="protein sequence ID" value="CAG5074832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2E5Z4"/>
    <dbReference type="OrthoDB" id="45365at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd18247">
        <property type="entry name" value="BTB_POZ_KLHL18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.420:FF:000001">
        <property type="entry name" value="Kelch-like family member 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011705">
        <property type="entry name" value="BACK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017096">
        <property type="entry name" value="BTB-kelch_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006652">
        <property type="entry name" value="Kelch_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030603">
        <property type="entry name" value="KLHL18_BTB/POZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45632:SF17">
        <property type="entry name" value="KELCH-LIKE PROTEIN 31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45632">
        <property type="entry name" value="LD33804P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07707">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01344">
        <property type="entry name" value="Kelch_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24681">
        <property type="entry name" value="Kelch_KLHDC2_KLHL20_DRC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037037">
        <property type="entry name" value="Kelch-like_protein_gigaxonin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00875">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00612">
        <property type="entry name" value="Kelch"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="BTB" evidence="5">
        <location>
            <begin position="52"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00043912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAG5074832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="588" mass="66042" checksum="6A266BEF8F36BCF2" modified="2022-05-25" version="1">MAAVVVVANNNTMASIVKVNQEKNDQTIYQESEIFSTGFTLFEEIRKTGKLCDVTLKVEDQSFSAHRVVLAATIPYFHAMFLNNMVESKLSEITLQGFESMALEALINYAYSGRIVLNKTNVQSIMVGASFLQLQSVRDACADFLKSHLHPNNALGISLFADRLNCSSLVQESTKYIQQYFHQVSLSDEFLVLSVTDLKELISKDDLYVMSESQVFEAVIRWIKHNVEERLIHLPKLLILVRLPLLSPEYLVDHVAKEDLIRRSHECRDLLDEAKDCHLMPERKHLLESYRFRPRVCTNIVGHIFAVGGLTKYGNSLSTVEVYDSAKGIWRKSEAMTMDRSRVGVAVHQNKLYAFGGYNGVERLATVEVYHPALKIWKIIAPMHHKRSAVGSAALNDYIYVCGGYDGVISLNTVERYCPKTDKWQLLRPMNKHRSAGGVVAFDGYIYALGGHDGLSIFDSVERYDPQTGLWTTVKPMLTRRCRLGVSTLNGKLYVCGGYDGSTFLQSVEVYDPIKDTWEYIAPMNMMRSRAALVSNMGKLWAIGGYDGVTNLSEVEVYDPQTNSWSFATPMCAHEGGVGVGVIPNPYC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2E6Y2</accession>
    <name>A0A8J2E6Y2_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Gustatory receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HICCMSTLAB_LOCUS1622</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Cell membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the insect chemoreceptor superfamily. Gustatory receptor (GR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001116">
        <property type="protein sequence ID" value="CAG5075468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2E6Y2"/>
    <dbReference type="OrthoDB" id="6366728at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050909">
        <property type="term" value="P:sensory perception of taste"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013604">
        <property type="entry name" value="7TM_chemorcpt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08395">
        <property type="entry name" value="7tm_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="54"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="83"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="142"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="167"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="251"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAG5075468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="371" mass="43367" checksum="9CEBA278BA1257E6" modified="2022-05-25" version="1" fragment="single">MNSRKFSKSELTSMFFIGAFFKISGLAPFRVSFLRKRYLGKPRISFHHSWKGTICNIVLLLPMVVELVTGIVKFKIYSQKGLLGLWISLAILWVIPVILLYFCFNQQKSIEILGKLVEIEYDLTDRFNRSVSRKHKNLNYEISLFIPQILFLVIHTTYIIIKFRSYGLFVIIISGFIINNLFLLYALLINFITKRYDFINEMLLTLIFRDQKTDLTFLTSSSQNEMTLKTLILIRKLQRKLYQVCKDVSNFFSWPILLVVILFCVRLIFYSFSFAKRLFICPKEINLMTLISEPVTLAKEIFVILVLAHHMSQFTFEIQKTGDIIYKIMDVYSMHGGIQSELEQFSIEILHRRIPNSIFGLFTIDGSLVTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2E865</accession>
    <name>A0A8J2E865_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Cc_odve66_25</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS2394</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001117">
        <property type="protein sequence ID" value="CAG5077189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2E865"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5077189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="333" mass="38565" checksum="FD627A284EB2A8E1" modified="2022-05-25" version="1">MIAMSIRAKKFALFGLVILVSAVACILTFTLLLATNHVENPKKVRAIKSSKLTQIKNDMKLLYDADLYEYNLNDSDVTMKDKVLNNNFENLSKEDKLREICVLGIKLLRNYLHDSSKTDYLKATSNIVDQILEKIKSIIAKTTFETDEEWELYIVDIPHLMAMYDLIVEDDSSNTNRLTQCYEYITKVINSNMESTYPKPTASKTDSKDSKSQFDFIKIGTPYLLTNYKRSLKDETYKNLFENAKKNKNLELVNKYLMTKEVSHKYGDFPDDGSQIKKQIADVFKCLDLLNIVKYNDLYIAVYNCLHVPGNINWRFQMMIARTLSMAESLKEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2E9D8</accession>
    <name>A0A8J2E9D8_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 10">Peroxisomal membrane protein PEX14</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 10">Peroxin-14</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">HICCMSTLAB_LOCUS791</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Component of the PEX13-PEX14 docking complex, a translocon channel that specifically mediates the import of peroxisomal cargo proteins bound to PEX5 receptor. The PEX13-PEX14 docking complex forms a large import pore which can be opened to a diameter of about 9 nm. Mechanistically, PEX5 receptor along with cargo proteins associates with the PEX14 subunit of the PEX13-PEX14 docking complex in the cytosol, leading to the insertion of the receptor into the organelle membrane with the concomitant translocation of the cargo into the peroxisome matrix.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9 10">Peroxisome membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the peroxin-14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001114">
        <property type="protein sequence ID" value="CAG5074019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2E9D8"/>
    <dbReference type="OrthoDB" id="441517at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990429">
        <property type="term" value="C:peroxisomal importomer complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005102">
        <property type="term" value="F:signaling receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016560">
        <property type="term" value="P:protein import into peroxisome matrix, docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025655">
        <property type="entry name" value="PEX14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006785">
        <property type="entry name" value="Pex14_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23058">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PEX14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23058:SF0">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PEX14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04695">
        <property type="entry name" value="Pex14_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 10" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="3 10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0811">Translocation</keyword>
    <keyword evidence="2 10" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Peroxisome membrane anchor protein Pex14p N-terminal" evidence="13">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="194"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="136"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="202"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="223"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="14">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00046271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU367032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF04695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CAG5074019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="245" mass="27405" checksum="06CD3B85B9091F89" modified="2022-05-25" version="1" fragment="single">ISTAVKFLQNPKVTASSSDKKYQFLLNKGLTDDEIKKAFSLASIVLPIDNKTGFTAVSIPSYNNNNNNSTNVDNNSVHNNNSVQIQPKWIYAVKDFINITAFIGTTLYCLHWAYKKFIEPLLFKSKKSPIKPVDKNEELLKDMKEMKKSMAKLEEKVDKITCNDMSDPSVPLLVQELKTDVASLKGLLLSRKQFPSAPPSIPSWQLDDTSNQNREKTTEDDAASGSSANNSDSSLEMIREQLLLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2EKI5</accession>
    <name>A0A8J2EKI5_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Mitochondrial (Mus musculus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS1776</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001116">
        <property type="protein sequence ID" value="CAG5075622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2EKI5"/>
    <dbReference type="OrthoDB" id="10268103at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004479">
        <property type="term" value="F:methionyl-tRNA formyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005793">
        <property type="entry name" value="Formyl_trans_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011034">
        <property type="entry name" value="Formyl_transferase-like_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11138">
        <property type="entry name" value="METHIONYL-TRNA FORMYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11138:SF5">
        <property type="entry name" value="METHIONYL-TRNA FORMYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02911">
        <property type="entry name" value="Formyl_trans_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50486">
        <property type="entry name" value="FMT C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Formyl transferase C-terminal" evidence="1">
        <location>
            <begin position="18"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5075622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="139" mass="15839" checksum="E852519C5303A4B6" modified="2022-05-25" version="1">MLNSGKPQSEIDVTYAPKITRKLSSVNWNELSAKNVYDIQRALTGIYPLITNYNGEKMKIFGVKLLNNPSDKSITSQITPGLMMFDKKLNLLIVQCKDGNWISVEQVSLANRKKMSAKEFYNGFLSRKENRVVLKYSND</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2ELD5</accession>
    <name>A0A8J2ELD5_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Similar to A4galt: Lactosylceramide 4-alpha-galactosyltransferase (Mus musculus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HICCMSTLAB_LOCUS2336</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyltransferase 32 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001117">
        <property type="protein sequence ID" value="CAG5076967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2ELD5"/>
    <dbReference type="OrthoDB" id="409543at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035248">
        <property type="term" value="F:alpha-1,4-N-acetylgalactosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006688">
        <property type="term" value="P:glycosphingolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007652">
        <property type="entry name" value="A1-4-GlycosylTfrase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051981">
        <property type="entry name" value="Glycosyltransf_32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007577">
        <property type="entry name" value="GlycoTrfase_DXD_sugar-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12042:SF21">
        <property type="entry name" value="ALPHA1,4-GALACTOSYLTRANSFERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12042">
        <property type="entry name" value="LACTOSYLCERAMIDE 4-ALPHA-GALACTOSYLTRANSFERASE ALPHA- 1,4-GALACTOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04572">
        <property type="entry name" value="Gb3_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04488">
        <property type="entry name" value="Gly_transf_sug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha 1,4-glycosyltransferase" evidence="8">
        <location>
            <begin position="227"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAG5076967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="356" mass="41329" checksum="5B13F7750D92A547" modified="2022-05-25" version="1">MKKQMVIVFGFSITLYALWIFNYSYLKNTTVENNQFPVVNVVKKEVNKEISCYFDPSTIYSIETFNEKEEITDDNNIFFIETSCSGAAGIELNARQCCSIESAAKMNPKMKIYLLILSPSEYSPRTEELLSHLEEYKNIVVRRIDIEDYVKNTPLEDWWQKGELTTSKWPKHHMSDVLRYLTLWKVPGIYMDLDVVTLSSFEKLRDFVGAEDEDTIASCMMSFGGSEIGREVADACINDLKNNFRGDVWRNNGPDVITRVIEKICEKPITNETHNCNGFTVFSPWEFTPIYYDEWRKYFEAENKDKTLKLINKSLAVHIWNKMSHLQPIKVGSQVPYGIIASQFCPKIYNNCGLWF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2ELG2</accession>
    <name>A0A8J2ELG2_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cc_odve66_27</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS2396</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001117">
        <property type="protein sequence ID" value="CAG5077196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2ELG2"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5077196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="233" mass="26788" checksum="BC9D3BD77092DE87" modified="2022-05-25" version="1">MITTTTKEIKTNTKEINNETKINNKSKEITDQTKSAIVEDTRNLSGEKSLSKSNDKETPVKDEIPTPVETLKLTEIKNTIKSFYVDEYNLIDNDTKIRDDALNDRFEDLNQEANLREICLLGIKLLRNYLKDPNNNTNYLNITGKIVDKVLTQTNNINAGKTFGTDEEWELYIVDIPHLMAMYDLLVEDDSSNSTRLTQCYEYIKKVINSNMEPIYSRPTPSKTDFIKIGTPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2ELW5</accession>
    <name>A0A8J2ELW5_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to Cul5: Cullin-5 (Rattus norvegicus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS229</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cullin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001106">
        <property type="protein sequence ID" value="CAG5073098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2ELW5"/>
    <dbReference type="OrthoDB" id="27073at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1310.10:FF:000015">
        <property type="entry name" value="Cullin 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1310.10:FF:000017">
        <property type="entry name" value="Cullin 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1310.10">
        <property type="entry name" value="Cullin Repeats"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045093">
        <property type="entry name" value="Cullin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001373">
        <property type="entry name" value="Cullin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016159">
        <property type="entry name" value="Cullin_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11932">
        <property type="entry name" value="CULLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00888">
        <property type="entry name" value="Cullin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74788">
        <property type="entry name" value="Cullin repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cullin N-terminal" evidence="2">
        <location>
            <begin position="12"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5073098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="279" mass="32431" checksum="B2DC89B87B8E7B87" modified="2022-05-25" version="1" fragment="single">DPKSQLPFEEKWPSMRPIILKLLKQEPVTQGEWQDLFYSIYTVCLWDEKGAQKMRDALKEDIMDFIKQAQQRVLAHQEEQALLKAYIQEWRKFFTQCNYLPTPFRQLESSLAGKTSSGGSGVQKKAQAEESLVRKMMLDSWNQSIFIDIKQRLQDSAMKLVRAERNGEAFDSQLVIGVRESYVNLCSNPNDKLQIYRENFEAAYIETTQSFYWIKAPEQLHAHGVEHYMRYAEAKLREEELRAQKYLEPNSSSVQLLTDCCVKVLVATFKAAILGECPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2EMF2</accession>
    <name>A0A8J2EMF2_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">E3 ubiquitin-protein ligase</fullName>
            <ecNumber evidence="10">2.3.2.26</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">HICCMSTLAB_LOCUS711</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="10">E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.26"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 10">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the UPL family. K-HECT subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.26" evidence="10"/>
    <dbReference type="EMBL" id="CAJNRD030001114">
        <property type="protein sequence ID" value="CAG5073939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="412600at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070534">
        <property type="term" value="P:protein K63-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009966">
        <property type="term" value="P:regulation of signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00078">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000051">
        <property type="entry name" value="E3 ubiquitin-protein ligase HECTD1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000085">
        <property type="entry name" value="E3 ubiquitin-protein ligase HECTD1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.260:FF:000014">
        <property type="entry name" value="E3 ubiquitin-protein ligase HECTD1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2410.10:FF:000007">
        <property type="entry name" value="Putative E3 ubiquitin-protein ligase HECTD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.20:FF:000372">
        <property type="entry name" value="Putative hect e3 ubiquitin ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2160.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2410.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000569">
        <property type="entry name" value="HECT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035983">
        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045322">
        <property type="entry name" value="HECTD1/TRIP12-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010606">
        <property type="entry name" value="Mib_Herc2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037252">
        <property type="entry name" value="Mib_Herc2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012919">
        <property type="entry name" value="SUN_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45670:SF1">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE HECTD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45670">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE TRIP12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00632">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06701">
        <property type="entry name" value="MIB_HERC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07738">
        <property type="entry name" value="Sad1_UNC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00119">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56204">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159034">
        <property type="entry name" value="Mib/herc2 domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50237">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51416">
        <property type="entry name" value="MIB_HERC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 9 10" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="repeat" description="ANK" evidence="8">
        <location>
            <begin position="402"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="8">
        <location>
            <begin position="433"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="domain" description="MIB/HERC2" evidence="13">
        <location>
            <begin position="1275"/>
            <end position="1347"/>
        </location>
    </feature>
    <feature type="domain" description="HECT" evidence="12">
        <location>
            <begin position="2026"/>
            <end position="2467"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="249"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="491"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1349"/>
            <end position="1378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1461"/>
            <end position="1483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1355"/>
            <end position="1371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1465"/>
            <end position="1474"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="9">
        <location>
            <position position="2436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU369009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CAG5073939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="2467" mass="270420" checksum="8508BA275B39FE31" modified="2022-05-25" version="1">MADVDPETLLEWLSMSQGDERDMQLIALEQLCMLLLMSDNVDRCFEICPPRTFLPALCRIFLDEHAPDSVLEVTARAITYYLDVSAECTRRVVGMEGAVRAICGRLSGAALGCRASRDLAEQCIKVLELVCAREAGAVFEAGGLPCALGFIRENGARVHRDTLHSAMAVVSRLCGKVEPQDKTLPDCVEALSTLLRHEDAHVADGALRCFASLADRFSRRGTDPAPLASNGLVSELLYRLSNAAGPGTSIAAAANNPKTPPPSTTSSTIPAPEPKSCASVSTIISLLSTLCRGSPSITHDLLRSDLPDAIEKALKGDERCALDSMRLVDLLLVLLFEGRSALGRGGAAGGPSGPLLPRLRRLDSAGEKSHRQLIDCIRSKDTDALIEAIDSGGIEVNFMDDVGQTLLNWASAFGTQEMVEFLCDRGADVNKGQRSSSLHYAACFGRPAIAKVLLRHGANPDLRDEDGKTPLDKARERVDEGHREVAAILQSPGEWMLPPSNQEHRKQDSDVDSEYTEPKGDPEMAPVYLRRLLPVFCATFQSTMLPSVRKASLNLIRKMVHYIQPDLLVETCGADKTAGCGAMLVEVIANVLDNEDFEIKATPPPPPPLKLIVGPKLPCLRKSTSTSSSSQNYIIDKTEDEDGHLVILQMIQDLMMKGKDEFLEHFARLGVFSKVATLAGPQDTPAEPENEPVVATASTGDEHKLEDARELLVGRAYHWRDWCICRGRDCLYVWSDAAALELSNGSNGWFRFILDGKLATMYSSGKGRNTESLTTEVMASIAESRGEFLEKLQRARGQVKPNTVSQPVLSKPGPTRLVVGPDFAAGWAGKRCKRLRSKIEAIKQKVKTQAQEIYESYFKAAQAQPRGVVAKLAAIVTQIDKAYQKQLSGNREWRSVLQSALEELKMLLNEEGRVSAYELHSSGLVQSLLGLLANPSGPQVTTVRANRMRLQRIAVFKSCFKAKDTNDGNSAKVLVQKLVSVLESIEKLPVYLYDTPGSGYGLQILTRRLRFRLERAPGESALIDRSGRSLKMEPLSTIQQLENHLLKMIAKQWHDHDRSTFTFVKKLKEGTKMTFQYSHDFDENGILYWIGTNAKTSPEWVNPGQYGLVVVTSSDGRSLPYGHLEDILSRDQSALNCHTNDDKRAWFSIDLGVWVIPSAYSLRHARGYGKSALRNWMFQASKDGINWTTLYTHIDDCSLNEPGSTATWTLEPPGEETQGWRHLRLQQTGKNASGQTHYLSVSGFEVYGEVTGVCEDLGRAAREAEAGVRRQRRLIKTQVLKHLVAGARVARGLDWKWKDQDGVPPGEGSITGELHNGWIDVTWDHGGSNSYRMGAEGKYDLRLVGTGMDGENKNKNGSGVLTGRKSSSTPSLPDCTDVSMRNSVASTEQAASAENLAAKQAAESIAESVLSVARAEAVVAVTGEGGASNTGELSVVLHPRPDTTVTSDLVTIVESLALNTDCPPNSNSNRASSSKPLFSTVRGNKPTSGLLSLEASEVLDRLREGADRLRNNTNSFLSAGGCPVVVTNPMSVSVPNLACTDANNTLETTTATGLLETFAAMARRRTLGPAGGQHIAPNSNVTQNTRGPTSVSNFVRLALSSNFTGGLLSTAQSYPSLTSSSQVAGSGVSLEDFLESCGGVASSSIGGVRTTGGPTLLGELDDDEEVLAEEDDDNEENDPEIDLLIQDDDEENEEEVEGGEAEYEEVMVSRNLLAAYMEEETPQSTKRRAWDDEFVLKRQFSALIPAFDPRPGRTNINQTTDLEVPQPGSDLQSSVRVGTVSSPRLSLSLKGPGLPDTPDVELSLTDPNASIFQAVQELMQMTELGSRQEKLRRIWEPTYTIIYRESKDEESSGRATPIVTLYSGKPAVSNNACTVEDVLQLLRHVYVLSITRDDRRDMTINEDSLESACWVNPDDFTSKKITNKVIQQIQDPLALAAGALPAWCEELARSCPFLLPFETRRLYFSCTAFGASRSIVWLQTQRDAILERQRAPGLSPRRDDSHEFRVGRLKHERVSVPRGEKLLDWAEQVLKIHAHRKSILEVEFVGEEGTGLGPTLEFFALVAAELQRKDLGLWLCDDHDQSEGYSCPSDEQTRPAGYYVIRASGLFLAPLPQNSEACDRAVRYFWFLGVFLAKVLQDNRLVDLPLSRSFLKLMCRGDIANNVNEKIGLTGVTQESISSSMASSFISEEGETDGLNSLEPSPWYDGILGIEDLVMVDPVRGEFLKEIQAVASRRERTISEGCSSSDEDPIRINHPSGTSVAIEDLGLTMSYSPGSKVFGYDHEELVEGGYDVGITVDNAREYAELTIDYCLNKGIARQLESFKAGFSKVFPMEKLHAFSPEEIRAMLCGEQNPHWTREDLLNYTEPKLGYTRESPGFQRFVNVLMSLTGPERKAFLQFATGCSALPPGGLCNLHPRLTVVRKVDAGAGGYPSVNTCVHYLKLPEYPTEEMLKERLLAATRERGFHLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H2F4</accession>
    <name>A0A8J2H2F4_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Similar to PIGU: Phosphatidylinositol glycan anchor biosynthesis class U protein (Homo sapiens)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HICCMSTLAB_LOCUS1386</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="pathway">
        <text evidence="2">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PIGU family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001116">
        <property type="protein sequence ID" value="CAG5075232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H2F4"/>
    <dbReference type="OrthoDB" id="549017at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042765">
        <property type="term" value="C:GPI-anchor transamidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016255">
        <property type="term" value="P:attachment of GPI anchor to protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009600">
        <property type="entry name" value="PIG-U"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13121">
        <property type="entry name" value="GPI TRANSAMIDASE COMPONENT PIG-U"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13121:SF0">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL GLYCAN ANCHOR BIOSYNTHESIS CLASS U PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06728">
        <property type="entry name" value="PIG-U"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="84"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="167"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="198"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="238"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="301"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="332"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="369"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="400"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAG5075232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="448" mass="51298" checksum="C620D93DC930AE95" modified="2022-05-25" version="1">MLSLKQLLYCSLAGGIRLILMNSQLQKIISDRVEISTALNSWKRVTEGVHLHNFGIDPYSGDLFHETPIGLVFFTWILRYLSFWSLRILFIVADLLTSWFLFQTARHYVKEVEKREKEEAKKIKKPAEELYTPLSKNSTEELSYTPISKTATSSVFYVPAAYLFNPYIVLNCVALTTTVFTNLLTSLALCFMIKKHKFATCLIISLLTLQNLYPASLIVAATIFVAKDAKTNRETVKVILTMVTLFLTILSLFIYLSYHIMGNWNFIKNTMGFILIVPDLRPNIGLYWYFFTEMFEHFRGLFIASFQINVGLLYVVPLALRLRNDPMLLSFAYLAIIAIFKSYPSLGDVGFYIALLPMWQHLFRHTQQGFIVGCFMLFCTVFAPTVWHQWIYSCSANANFYFGVTLAFAIAQIFLLTDVLFASVKRELALKSGIQNEINGNNAKLVLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H310</accession>
    <name>A0A8J2H310_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similar to UTG2: UDP-glucosyltransferase 2 (Dactylopius coccus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS317</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001114">
        <property type="protein sequence ID" value="CAG5073374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H310"/>
    <dbReference type="OrthoDB" id="5835829at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="110"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5073374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="375" mass="42704" checksum="79C5F86A758723B2" modified="2022-05-25" version="1">MMFFEQTMKGLARRGHQVDVISVFPQKHPYPNYTDLEIPPISPKLVNNMTFDFVKTFFEDVNIVYYVSDTFGNGVCEKGFKNPVVQKLIRNTSNPPYDLVIVEVIAKMKVVISFIAVILFKIAGCHGLRILGIFPLNARSHMMFHEQTMKGLARRGHQVDVVSTFPQKKPYSNYTDLEIPSALPKFVNNLTYDFAKAKLENNLVYFSAHEGGNILCDKGLRNLNLLNIVHNTQDPPYDLVVIENLLIILTILANCHGYRILGIFPWNSRSHMMFHEQTMKGLARRGHQVDVVSIFPQKKPYPNYTDIDIPSATPEWTNTATYGLMLEIMRSGIIHVLATVFGNFYCEKGLENPKVRALIENTNNVSYDLVIVESK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H3D3</accession>
    <name>A0A8J2H3D3_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similar to dia: Protein diaphanous (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS938</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001114">
        <property type="protein sequence ID" value="CAG5074166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H3D3"/>
    <dbReference type="OrthoDB" id="1104827at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005884">
        <property type="term" value="C:actin filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030041">
        <property type="term" value="P:actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051412">
        <property type="entry name" value="Formin_Homology_Diaphanous_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014768">
        <property type="entry name" value="GBD/FH3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010473">
        <property type="entry name" value="GTPase-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45691">
        <property type="entry name" value="PROTEIN DIAPHANOUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45691:SF6">
        <property type="entry name" value="PROTEIN DIAPHANOUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06371">
        <property type="entry name" value="Drf_GBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01140">
        <property type="entry name" value="Drf_GBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51232">
        <property type="entry name" value="GBD_FH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GBD/FH3" evidence="1">
        <location>
            <begin position="1"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5074166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="225" mass="25624" checksum="3FA426B351CC8AFA" modified="2022-05-25" version="1">MRFNSPDEYIQYLAQGGRSENNIYSCVQLLTKALEKNPLSWVHEFGFNGLNQVLRILYEIFQNNKPYERIQYECIRCLIAFGNNTVGLKALIEHQEALMIVVLFLDPSKPGTMYEALKLLGVTCLISNDTHKKVLNAVTMNGKLRRHKRFLPVVQGLMNRQNKDLRAACLQFINSVKQAASTESKRLILEKNAPETKTGIMDSLLEQLQAGTAFDLLNPGRKRHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H540</accession>
    <name>A0A8J2H540_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HICCMSTLAB_LOCUS1025</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the DEAD box helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="CAJNRD030001114">
        <property type="protein sequence ID" value="CAG5074334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H540"/>
    <dbReference type="OrthoDB" id="196131at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031047">
        <property type="term" value="P:regulatory ncRNA-mediated gene silencing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd17967">
        <property type="entry name" value="DEADc_DDX3_DDX4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000008">
        <property type="entry name" value="ATP-dependent RNA helicase RhlB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044763">
        <property type="entry name" value="Ded1/Dbp1_DEADc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 8 12" id="KW-0347">Helicase</keyword>
    <keyword evidence="3 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="10">
        <location>
            <begin position="192"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="11">
        <location>
            <begin position="386"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="33"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="45"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="62"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="75"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="100"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="115"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAG5074334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="582" mass="63329" checksum="1F8809401E04753F" modified="2022-05-25" version="1">MSDWLSGNNNSSEGRSHGRGRGFGSSESKNPGTNGGSGDWGTGTNGTEQTNGSNGADEWINGGNNDNTAGSEWLSSNDNYSGSNGYSNDNNDNDGEGGRGRGRGRGRGRGRGRGRGGDRDGGRDRGDFNQDSDYTGGGGRGRNRDRDGEGGDDGGDSDGLGPDGEEKKAPITYVPPERSMDDEEIFGTNHAIPIILQGRDLMACAQTGSGKTAAYLIPIVHRLLEDNNELKLTERGCEPQVIVMAPTRELVLQISWEAEKFAKDTIIKTVACYGGVKPMHQADQVRRGAHIIVATPGRLNDFVKGGRISFGSIKFMVLDEADRMLDSGFRSSMEEILEHEQMSPKDSRVTLMFSATFSDEVQELARKFLNNYLFLTVGIVGGANSDVEQIFYEVTKKDKRNKLKELLERDGGQSLKVKTIIFVETKKTADFIAAYMSDNLFPATSIHGDREQRERETALADFRSGKMPILVATSVAARGLDIKNVAHVINYDLPKCIDDYVHRIGRTGRVGNRGKATSFYTPENDDKMVADLIKVLTQAGQEIPEFFDAGGGFNAGESSSFGGYDIRDNYNQPADTETNEGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H572</accession>
    <name>A0A8J2H572_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similar to spop-b: Speckle-type POZ protein B (Xenopus laevis)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS1353</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001116">
        <property type="protein sequence ID" value="CAG5075199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H572"/>
    <dbReference type="OrthoDB" id="1893551at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24413">
        <property type="entry name" value="SPECKLE-TYPE POZ PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="152"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5075199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="316" mass="36763" checksum="6ED3201F3AA3D324" modified="2022-05-25" version="1">MSKESVKNQVITHEFLLTLEDNYHEWLKSSHVKLIDVDSCGEFYISVRLNKLSSLDVKVSKTVEKSAMAIIELRTNGMNWHVKDVPDWKDSCNFDVDFPYYYLQYSNNDCDDSFKFYLSIKCKITWFGFKDDLVFSNLYQNMKQFLLSIECSDVIIIVKNREFPTHKNILASQSPVLKSMLTTTDTKYKKKLLRLRKIEIDVAEELFLFLYTGKVNKANHDYDLAAKLLVVAKNYQIIQLINLCGLILSNNITKENALQLLKLSEGQKTDNVFILQERAAAFIWNNRREVLTLANFKDSSKFSPESLFKIIEKIPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H589</accession>
    <name>A0A8J2H589_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">F-actin-capping protein subunit alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HICCMSTLAB_LOCUS14</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="5">F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Heterodimer of an alpha and a beta subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the F-actin-capping protein alpha subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030000102">
        <property type="protein sequence ID" value="CAG5070425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H589"/>
    <dbReference type="OrthoDB" id="340550at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030863">
        <property type="term" value="C:cortical cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008290">
        <property type="term" value="C:F-actin capping protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051016">
        <property type="term" value="P:barbed-end actin filament capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1140.60:FF:000001">
        <property type="entry name" value="F-actin-capping protein subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1140.60">
        <property type="entry name" value="F-actin capping protein, alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002189">
        <property type="entry name" value="CapZ_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037282">
        <property type="entry name" value="CapZ_alpha/beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042489">
        <property type="entry name" value="CapZ_alpha_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10653">
        <property type="entry name" value="F-ACTIN-CAPPING PROTEIN SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10653:SF0">
        <property type="entry name" value="F-ACTIN-CAPPING PROTEIN SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01267">
        <property type="entry name" value="F-actin_cap_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90096">
        <property type="entry name" value="Subunits of heterodimeric actin filament capping protein Capz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0117">Actin capping</keyword>
    <keyword evidence="4 5" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU365077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAG5070425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="141" mass="16323" checksum="9080303D77BC2475" modified="2022-05-25" version="1" fragment="single">MLFESTPIHDRRYTCSTVSKMADDEFVAISDQEKVRIVSDFILHSPPGEFNEVFNDVRVLLNNDNLLKEGASGAFAQYNKDQLTPVKIEGSDYPALITEYNDLGNQRFYDGRSKLSFKYDHLRKEATDYEQYEPDVNVEPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H5S8</accession>
    <name>A0A8J2H5S8_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS1918</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001116">
        <property type="protein sequence ID" value="CAG5075900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H5S8"/>
    <dbReference type="OrthoDB" id="2095648at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5075900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1212" mass="140073" checksum="4E64F6653A3BD396" modified="2022-05-25" version="1" fragment="single">MELRLVCCHFNELIESILNKHPAWKPMTDNKILYECLEHTMQRAYPYVLISHWMDIDDPVIWRGTYLSFMKWQKVLVNEPTIDAIVSTSNFGDVSCVCTFDKYIAIAYENGAIANYTVDDINQPFYLAYHGTGITQIEFWYSNGDVLVVSLGDNNDLNSGECRHFCIGDMEGTLTSYERVGNFISPGSTKNLPLRETQQLIAHCYVGKNMKAMAYEESGTVLFVYWADIEGEKLTRFRFIQEKDWCRLPENINASFQRLIMPNITFFFAIGASSIGSTNYYENEWHEYNLAPHFGSNVRSIALHAQILIFGLDDGSIHLLYIRNYADVMDLEAKIQNSRKIEVDTEPIVDLTILEVDKKPCIVAVTEQKVHLLMELRLVCRHFNELIESILNKHPAWKPMTHNKILYDCLELTMQRAYPYDLITHWMDIDDPVIWRGTYLSFMKWQKVLVNDPTKDTIVSTSNFGDVSCVCTFDKYIAIAYENGVIANYTVDDISQPFYLAHHGAGITQIEFWYSNGDVLVVPLGDNNELKFWDLKNKVEIATNGFFAHNISSGECRHFCICDLGGILTSYERVGNLISPGLTKNLQIRENQELMAHCLVGKNMKAVAYEVGGTVLFVYKGDIEGGKLTNFRFIQKKDWIRLPDNLDSSLQRLTMTNITFFFGIGLYRIGSTNYYDDDWHEYDLAPYFGSNVRSIALHAQILMFGLEDGSVHLLYIQDYDHVMELEERIQNSRKIEVDTEPIIELTILEVDKKPCIVAVTEQRHLPAASLALKSFDKYQRSLHSNKTESISTFFTDNLLTFIDFQRRRLSKSLWKKIFEKLDFRTFVGLRMVNREFCKGVKKHLYELEVWRLMCYEQTLFDCRTMTMARRFPYELITHQSEVNDQDLWRGTYSSFKKWAKVIESPQNTQLMLSVSHLRTNITCVATFDKYLLISFENGDMNYYDYSAINKNVPVFTKSKTFCKADNRRERHKKSSILLGSQAKAKTFCRTGEGRHFCIGEYDGVLTSYELNSQDEIVPGAVYELNLRQNEFVANLCIDGKYITAMSMMAKAKRIGTILYFLAAIIEDNRVLYFEQEQEKDWIMLPEDLYEMRRLVMPTITFFLGLAESKIGSTNFYENEWHEYDIESILGSQITAVALHAQILIIGLHNGDIHFLHIENYMDIVNIEKRITSSAATNISSKPIIDLIIMEYQQNPSIVAVTKDEVILINFKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H6K9</accession>
    <name>A0A8J2H6K9_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Similar to lgr4: Leucine-rich repeat-containing G-protein coupled receptor 4 (Danio rerio)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HICCMSTLAB_LOCUS2923</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001117">
        <property type="protein sequence ID" value="CAG5079103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H6K9"/>
    <dbReference type="OrthoDB" id="2190652at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007616">
        <property type="term" value="P:long-term memory"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000770">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24366">
        <property type="entry name" value="IG(IMMUNOGLOBULIN) AND LRR(LEUCINE RICH REPEAT) DOMAINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24366:SF158">
        <property type="entry name" value="PLATELET GLYCOPROTEIN IB ALPHA CHAIN-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 7" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035234365" evidence="7">
        <location>
            <begin position="27"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="441"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="515"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="515"/>
            <end position="529"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG5079103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="630" mass="71184" checksum="7800D4C3ABCD8CCC" modified="2022-05-25" version="1">MATRSNLFPALSIVLLLSMTITTIETSGDLCPAICKCEDEFLRASCAYANLEVVPIQLNPEIHHLDLSINRITSLNLGFGFYNNLESLDLSYNILHTLGSDNFLLQTHMEILNVSNNNLRTIGRNSLRGLESLRIFDVNNNNITEMDSAAFRHTSELEDLNLSGNSLTSLPNDLFKNLHKIRNLKLNRNSLLEVPANNLHLVPSLENLELSDNLIQEISRDSLPTLRSLMSLNLANNLIQIINEEAFQRLPALVYLNLKGNNLTYVPTSALSHLSLLSNLILSRNPLEQLDNLAFRNLFELKTIDLRECTILYIKSRAFADNVNLEKIFLDGNHDLRHLPSRILYSARYLTTVSLRHCNLSSLEPTHFPVDGLNLLQIGGNPLICNCSLHWLWNVIHTTEENNGSKLFVDRGEIFCADDVFNGKLLMNLTESSLRCRLSSLYLSLLAAGCLTAAAIILILAGYITRNNRRKKTFNRPTRPELLVYVGLNEDVPKRTLVHSPINVDLYRSPLSSSSRRVSNVQRSSNNHNDMSSASFYQTQHDRDLTLDDNTFNEPIENLNRCRNSDMENLGAVNNDPNLQKSEVYDNSSVYGVQNSNLRCQKSSTDSDYEYEYYSSPMVLSAQKPHIVFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H762</accession>
    <name>A0A8J2H762_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS3261</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5081356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H762"/>
    <dbReference type="OrthoDB" id="416222at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050663">
        <property type="entry name" value="Ankyrin-SOCS_Box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24193:SF121">
        <property type="entry name" value="ADA2A-CONTAINING COMPLEX COMPONENT 3, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24193">
        <property type="entry name" value="ANKYRIN REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5081356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="190" mass="21536" checksum="36A3EE843C31BB42" modified="2022-05-25" version="1">MMVKKYSQGKNSKFGRYSKKKDKKYFFKKKNPKKRVNPLVVQKAIECPWITSIRRFLQTSMDVNLLNLTEPLLHTAVRISKYTMVQQLLAAGADPNDVPKLGDCGHPPKFLVPSPKIQCPCPPLIIAVDRGNEKMAKLLIQNKADPNIVSCYGSALNIAVEKDSYRADNNLLTIIEIKAFNFFLEQLVKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H943</accession>
    <name>A0A8J2H943_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similar to Rundc1: RUN domain-containing protein 1 (Mus musculus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS4122</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5084507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H943"/>
    <dbReference type="OrthoDB" id="10068328at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd17683">
        <property type="entry name" value="RUN_RUNDC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.900">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004012">
        <property type="entry name" value="Run_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037213">
        <property type="entry name" value="Run_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058732">
        <property type="entry name" value="RUNDC1_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047343">
        <property type="entry name" value="RUSC1_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15591">
        <property type="entry name" value="RUN AND SH3 DOMAIN CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15591:SF19">
        <property type="entry name" value="RUN DOMAIN-CONTAINING PROTEIN 1 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02759">
        <property type="entry name" value="RUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26030">
        <property type="entry name" value="RUNDC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00593">
        <property type="entry name" value="RUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140741">
        <property type="entry name" value="RUN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50826">
        <property type="entry name" value="RUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RUN" evidence="1">
        <location>
            <begin position="338"/>
            <end position="519"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5084507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="530" mass="61112" checksum="B784F79690496DCB" modified="2022-05-25" version="1">MDRLKILEEEQDVLNSSLISLTTHFAQVQFRLRQIVDAPSDQKENLLKELEEFAFRGIPDVSSILLCKSEANTALVPSTDSSLHISNDECTDIELESKIAQRKLKQKELIEQLKTQLEDLERYAYETDGQDLPQSVILERQNLLINHLKEKLNFEVDDLCKLSVDDLRWQVDHAINEIVNPLKMKEQLVNQLKTQVSDLERFIHYLQGEVSTEAYACTCTCPVHTNSAKLSAKKSRKPFPQEHTNDGNHTKTLNTVRKVITLLHLYLMSQLGCGRDRVRRNIDKNSDIPVWRDMRARLDTAIEDVLQNVAAMERHFEDEDYNSHTSDLDLSKAQFNARITASVRKHLAICIRDLIQHGLTSDVRASNSVVPFVGCFPQKKSVSHNFMHAWELIIKYYEIKNGHIYNSSPAQKLSQSFNLDLVNRRSISPKQILLITIGNIIATHTPYKRSHNSHFKAFICAALNTNKLVIWLRYILQCQYLLENYYTSWSYVVKTGFQDAFHTLDRLSSVRFDLPVDLAVQQFQNIKDAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HB89</accession>
    <name>A0A8J2HB89_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Similar to Ester hydrolase C11orf54 homolog (Mus musculus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HICCMSTLAB_LOCUS5755</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subunit">
        <text evidence="2">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5090809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HB89"/>
    <dbReference type="OrthoDB" id="5119241at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17298">
        <property type="entry name" value="DUF1907"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015021">
        <property type="entry name" value="C11orf54_DUF1907"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13204:SF1">
        <property type="entry name" value="ESTER HYDROLASE C11ORF54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13204">
        <property type="entry name" value="PTD012 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08925">
        <property type="entry name" value="DUF1907"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01168">
        <property type="entry name" value="DUF1907"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117856">
        <property type="entry name" value="AF0104/ALDC/Ptd012-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="DUF1907" evidence="7">
        <location>
            <begin position="27"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG5090809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="314" mass="34864" checksum="B9C3AE1A99801B6D" modified="2022-05-25" version="1">MAENSGDQMKINQVTLFTPTLNEIKNVITPALATNFEEIAVDVVDCPDLTKVPFQLAFEGLGGHPKLFDIGGPPFLLPSVQRNKIYDVQTILKQINYNNKAFVIGAGAGPWPQLSRNCEMMMNVVIDSDEIKNQTKLAWVGDDNQCVLQNCKESDTRLALLANLFVSEGKPGKVIKVYAKTRTGNLDFITTIQNALSARYRGMGGTFLIKQGKVKQHVMPDFSPVPLNSEKSLNDWLHFYNMSAPLVAVGTLVSAESNLDLRVQHFHSFSDHGEGGHYHIDVTPDTVEYLGYFNIADCLYRIDQPPKSVLFGKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HBA3</accession>
    <name>A0A8J2HBA3_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to fer3: Protein Fer3 (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS6341</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5092729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HBA3"/>
    <dbReference type="OrthoDB" id="6375462at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032502">
        <property type="term" value="P:developmental process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050283">
        <property type="entry name" value="E-box_TF_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23349">
        <property type="entry name" value="BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTOR, TWIST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23349:SF63">
        <property type="entry name" value="FER3-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BHLH" evidence="2">
        <location>
            <begin position="101"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5092729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="148" mass="17205" checksum="A6534B0160E890A8" modified="2022-05-25" version="1">MNYNEPLWEINGNQAPIITSEMSQYVGSEMASYPMWDSSVLYQTPPPSLSHVNDHVNGFYRQPCALLHQRDIDSRYSHNGRMPNQPTSSSKKPRRRVASVSQRRAANIRERRRMFNLNEAFDKLRKKVIKFVLKVSFLAMGENFSIKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HBT8</accession>
    <name>A0A8J2HBT8_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS4322</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5085257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HBT8"/>
    <dbReference type="OrthoDB" id="7661986at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032062">
        <property type="entry name" value="DUF4803"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47890">
        <property type="entry name" value="LD24308P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47890:SF1">
        <property type="entry name" value="LD24308P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16061">
        <property type="entry name" value="DUF4803"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5085257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="432" mass="49452" checksum="26F25D3FFF900339" modified="2022-05-25" version="1">MEIHMARVHGSYGKSTKETILDNWVVRKTDKRKVHGETYFRLNDLFGMYYVNRKQLNTLVPYDPAEINTLSYIECLDRYSSNDVFINFYCPRYECYGRLHKCREAGSFNFCEARTGANRRYAFTLDGKQFPTRPYDCNGRFVDTLAKETDNLLCQCSEEGAESLATKAINLMPQMSDIENNMVVTNVRFLKKNNMVHMQIEEGLLLPDGNIDKSTVSSVPVGNFRYLQNSTQGSFVQLDPTEWDDRLIQLNYDRDYTFLYHNRSTINLDDIIVDVGYVVTGVKFDTEENNPGTGINYSPIQLKVHGTPFNYDTGLLEPTDKKPSRWFTPFDMKGKIKRYSYMREMLDITNSDDSIKNTGAVQQYPTNFQVTFQVTSWEKDMGQTVVPYFDTLSAAVSNKVALDGVGISYRGSQGFGGFIAPKIFNVDHAQTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HD35</accession>
    <name>A0A8J2HD35_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="24">Aminopeptidase</fullName>
            <ecNumber evidence="24">3.4.11.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="29" type="ORF">HICCMSTLAB_LOCUS5644</name>
    </gene>
    <organism evidence="29 30">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="29" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of an N-terminal amino acid, Xaa-|-Yaa- from a peptide, amide or arylamide. Xaa is preferably Ala, but may be most amino acids including Pro (slow action). When a terminal hydrophobic residue is followed by a prolyl residue, the two may be released as an intact Xaa-Pro dipeptide.</text>
            <dbReference type="EC" id="3.4.11.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="22 24">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="22 24">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 24">Belongs to the peptidase M1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="29">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.-" evidence="24"/>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5090467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HD35"/>
    <dbReference type="OrthoDB" id="510539at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016285">
        <property type="term" value="F:alanyl aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042277">
        <property type="term" value="F:peptide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043171">
        <property type="term" value="P:peptide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09601">
        <property type="entry name" value="M1_APN-Q_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.390.10:FF:000001">
        <property type="entry name" value="Aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.50.20:FF:000001">
        <property type="entry name" value="Aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1910:FF:000008">
        <property type="entry name" value="Aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1730:FF:000012">
        <property type="entry name" value="Aminopeptidase N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.50.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="entry name" value="Neutral Protease Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1730">
        <property type="entry name" value="tricorn interacting facor f3 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045357">
        <property type="entry name" value="Aminopeptidase_N-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042097">
        <property type="entry name" value="Aminopeptidase_N-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024571">
        <property type="entry name" value="ERAP1-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034016">
        <property type="entry name" value="M1_APN-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001930">
        <property type="entry name" value="Peptidase_M1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050344">
        <property type="entry name" value="Peptidase_M1_aminopeptidases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014782">
        <property type="entry name" value="Peptidase_M1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11533">
        <property type="entry name" value="PROTEASE M1 ZINC METALLOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11533:SF294">
        <property type="entry name" value="THYROTROPIN-RELEASING HORMONE-DEGRADING ECTOENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11838">
        <property type="entry name" value="ERAP1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01433">
        <property type="entry name" value="Peptidase_M1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17900">
        <property type="entry name" value="Peptidase_M1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00756">
        <property type="entry name" value="ALADIPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63737">
        <property type="entry name" value="Leukotriene A4 hydrolase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 24 29" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="18" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="19" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="12 24" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="20" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="17 24" id="KW-0472">Membrane</keyword>
    <keyword evidence="10 22 24" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16 24" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="8 24" id="KW-0645">Protease</keyword>
    <keyword evidence="30" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 25" id="KW-0732">Signal</keyword>
    <keyword evidence="14" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="9 24" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="15 24" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="13 22 24" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="25">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035278031" description="Aminopeptidase" evidence="25">
        <location>
            <begin position="25"/>
            <end position="945"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="50"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="domain" description="Aminopeptidase N-like N-terminal" evidence="28">
        <location>
            <begin position="119"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M1 membrane alanine aminopeptidase" evidence="26">
        <location>
            <begin position="351"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="domain" description="ERAP1-like C-terminal" evidence="27">
        <location>
            <begin position="672"/>
            <end position="944"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="21">
        <location>
            <position position="424"/>
        </location>
    </feature>
    <feature type="binding site" evidence="22">
        <location>
            <position position="423"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="22">
        <location>
            <position position="427"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="22">
        <location>
            <position position="446"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="23">
        <location>
            <position position="509"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="PIRSR" id="PIRSR634016-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="PIRSR" id="PIRSR634016-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="PIRSR" id="PIRSR634016-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="RuleBase" id="RU364040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="Pfam" id="PF01433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="27">
        <source>
            <dbReference type="Pfam" id="PF11838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="28">
        <source>
            <dbReference type="Pfam" id="PF17900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="EMBL" id="CAG5090467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="30">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="945" mass="108816" checksum="D6B5AC304406B1AA" modified="2022-05-25" version="1">MKICNDLYLLLFVCFSSLNAMTQSCEVLAMMDAHTTTFGRKRGCTISKCGAFLITIFFIFGIVATGLLVYHFAPCLDGKSVKNTDDFGDGAFLNSARTFATVEAHKKKINVRLPKSVIPDTYEIKLMPFIWEGNFTFNGEVTIYVNVTMDTKNITLHATDMKIHYQSTTLKEYNFNPNTNSKNIGKWIKIFDQTNDTARQFHIIHSSETLKAGMQYIIKLKFVGYLNDYLQGFYRSSYTEGNKTRWIATTQFQATDARRAFPCFDEPSLKAKFQISIARPSHMVSVSNMPRISKPEPAREMATYVWDHYEKSVPMSTYLVAFLVTDFDVLKTSDNFFGVWARKEAIEQARYTLDVGPKILKYYEDYFKIKFPLPKIDMVAIPDFAAGAMENWGLVTYRETAMLFQDGISTSNSQQRVATVIAHELAHQWFGNLVTPSWWSDLWLNEGFASYVEYIGVDSVEPDWKILEQFVTYEVQNVFNLDALASSHPISIEVGHPDEISEIFDRISYGKGASIIRMMDHFLTTNVFKQGLTNYLIEKAYGNSEQNDLWNALTDEAHKNNVLPSEVTVKRIMDTWTLQTGFPVVTVIRDYKSGGAYLTQERFMLQNSTTTVTMVGTNEEIKDENEKEALWWIPITYTTEAIKNFNSTKPSNWMNAKYSLTLQNIDASNNQWIIFNILETGFYRVNYDKRNWQLIITQLNDRENYKDIATINRGQLIDDALNLARAGRIDYSTALDVTTYLRHETEYIPWKSALTALNYIDNMLNKYQGYDRFRVYIVRLLDNVYRKIGFKDMPGDPQLTVFTRIDILLWACTFGHDDCVRNAVMQFQNWRNSPDPDANNPISPNLKSVVYCTAIKTGGQAEWDFAWERYRKTNVGSEKDILMYALGCAREPWILSRYLEWATTENSGIRKQDTSRVFSAVANNPIGQPLVFSFLRNQWARLKKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HDB5</accession>
    <name>A0A8J2HDB5_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Similar to wtap: Pre-mRNA-splicing regulator WTAP (Danio rerio)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HICCMSTLAB_LOCUS6039</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the fl(2)d family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5092313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HDB5"/>
    <dbReference type="OrthoDB" id="3366661at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016556">
        <property type="term" value="P:mRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000381">
        <property type="term" value="P:regulation of alternative mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033757">
        <property type="entry name" value="WTAP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15217:SF0">
        <property type="entry name" value="PRE-MRNA-SPLICING REGULATOR WTAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15217">
        <property type="entry name" value="WILMS' TUMOR 1-ASSOCIATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17098">
        <property type="entry name" value="Wtap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="334"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="72"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="8"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="360"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="377"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="389"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG5092313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="465" mass="51866" checksum="51399E2BDFA37C9D" modified="2022-05-25" version="1">MAEESTGDSKQGQLSPRSPSGAGVAGGVVNKPTSPRSPAAKPTRRVRLTDQQLEAASKEELAGKWREQESYIEILEAQASAQDAELTSLKESEEKFRQQFTEASYREKILVRRLASKEQELQDYVSQITELKAAQTPSVSSLRSALLDPAVNILIQKLRQELLTTKAKLEDTQNELSAWKFTPDSNTGKRLMAKCRLLYQENEDLGRMISSGRIAKLEGMQSTIYFLQQELRKARESVTLLQQENLALKSLPNENNLSNGLSPHTPPIIKKEEEQDELENEVIMSKSLAIEPEEYKVDEDGACTPPLKNQVAIPANQENDESSSDSAALIIKVENEELTDRENEEDENKSGRTLRRTKGAKCCSSGSSSAGDKTNGDDSTSSRTTNALRLRDRGDCRTVDSRGDRERTKRDKSAHSSDEEQHHQIRDCGRLKKKRRESILSIDYNDADDDAIVLTNGETLQSDPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HDK0</accession>
    <name>A0A8J2HDK0_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Similar to INTS4: Integrator complex subunit 4 (Homo sapiens)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HICCMSTLAB_LOCUS7544</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5095108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HDK0"/>
    <dbReference type="OrthoDB" id="18190at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032039">
        <property type="term" value="C:integrator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016180">
        <property type="term" value="P:snRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056235">
        <property type="entry name" value="INTS4_8HBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057412">
        <property type="entry name" value="INTS4_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20938">
        <property type="entry name" value="INTEGRATOR COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20938:SF0">
        <property type="entry name" value="INTEGRATOR COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24493">
        <property type="entry name" value="INTS4_8HBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25458">
        <property type="entry name" value="INTS4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="INTS4 8 helical bundle" evidence="3">
        <location>
            <begin position="575"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="domain" description="INTS4 8 helical bundle" evidence="3">
        <location>
            <begin position="658"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="domain" description="Integrator complex subunit 4/Protein SIEL C-terminal Ig-like" evidence="4">
        <location>
            <begin position="750"/>
            <end position="875"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF25458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAG5095108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="880" mass="97654" checksum="5AD35E0A34BD7443" modified="2022-05-25" version="1">MAALMKKRVLAEFNQSQVVTGEPPIKRLRTLRLQSTSSTKNGSDGCSALAYVECLEKCKGGNDALQLLVRISDTLSRMSSEDVPLTVTKLIERFGIETEAAVRAKILWVLAELGEVTTQSSEKVRIIEETSRLLKNEESHRVISQGLSTLLKLGDYHRLGVLKIAREHLSDTWHGVQTRCLSIIGRYLSLNSNDDTLVLVSHYARSQDPRVRAAAFETMAELHSERGCRLTPNFFTEACNALRDDYEIVRRAVLKLIWMLGVEYPEEIIVGTDGEDTRMIDSAFSKLCGLIGDLSPRVRATAMSLMGAMKNVSSRYIEQALDKKQMRVEDEGSEIEERSASCGAFIHGLEDEFLEVRTAAVESLCTLSLERPAIARIALDFMVDMFNDEIQDVRIKAIESLRKMSTSVTLQEDQLETILCALEDFSDEVREGLHATLAASRLATRNCLHMCVNRLIDNLTRYPQDKDSIRSCLAALGASHPYLTLPLVPQLLGRHPFFDTPEPDVDDPSYASVLVLIFNAALHCPSMHALFSEHAAKHYHYLRDTMPHLVPRLRPALARAPGIDVSDEKDDKRGQEFLERMVAGVENARPGGKVYVQLLEAAAVDLDRLAEMDRKMEGAAHFTALYVRCLLLLRSVVKEITESQTEATPISTLPSTNTLAVELIRITKSATGSALPLARQFLSEADSLPQDTSKLPPFSRALVMEIPSMADAKPGSLSRLLLPLLTTLPARGEERLPRPSVSTKLCRAIIEEPRGDADAALKFTGGLILGIPLTAKILNLRDPSTIRIKLRHPDQQVQLLLPKKADLRPQNSEGTDYRLKTTVLLSHQVWMEACNVEVSIALLVSSSNTSTYSPNDDPYILELCKPTKVSIAPKPIKRAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HDL9</accession>
    <name>A0A8J2HDL9_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Wiskott-Aldrich syndrome protein family member</fullName>
            <shortName evidence="7">WASP family protein member</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HICCMSTLAB_LOCUS7687</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Downstream effector molecule involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Promotes formation of actin filaments. Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Binds actin and the Arp2/3 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Cytoplasm</location>
            <location evidence="1 7">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the SCAR/WAVE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5095394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HDL9"/>
    <dbReference type="OrthoDB" id="1060785at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031209">
        <property type="term" value="C:SCAR complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071933">
        <property type="term" value="F:Arp2/3 complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034237">
        <property type="term" value="F:protein kinase A regulatory subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000601">
        <property type="term" value="P:positive regulation of Arp2/3 complex-mediated actin nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.340:FF:000012">
        <property type="entry name" value="Wiskott-Aldrich syndrome protein family member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.280.150">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028288">
        <property type="entry name" value="SCAR/WAVE_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12902">
        <property type="entry name" value="WASP-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12902:SF1">
        <property type="entry name" value="WISKOTT-ALDRICH SYNDROME PROTEIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="3 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="172"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="503"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="196"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="259"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="288"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="311"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="328"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="341"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="368"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="400"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="504"/>
            <end position="520"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU367034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAG5095394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="527" mass="57416" checksum="3BF49DC05D607F46" modified="2022-05-25" version="1">MPLPKRLVEPVHVARGTIPEAFPLPSELEAATNGTLANTIRQLSSLSRHAEDLFGELAREAHTLSDRANSLQARIDRLAVKVTQLDSNVEEVSLQDIHMRKAFKSSVVFDQQVVSRDTMPTAMRETYQACDTPPPLDKLNVYREDGKDGLKFYTDPNYFFDLWSQEMLKDTEKKLHDRGKKPHRPRNDGGNSGGGGRHKKRVRQPHNTRERQRQLAVGHGEYIMPTQGVQYRTPHNIPDESLLGMVMTEPRPPRPNSIELRRSYPPDEQHFSHYAPGQGQPGSEAYQSPGPGTPSRGGRSRPSQPPPAPPSNASSNSTPTVASANNTPTRGRSMSTGRDTLPPPPPPPGEVMSPPPINGTIPAHLLNRNGSRSNSPLPSHQSTPTPPNHTLPAGIDEPDPAPQDLPPPPPTPDPAPSRPISPPCNIPPPPPPPPPPPVLNGPISCVPISNGDIAKIIANNPPKLKPLKSILRKVEKIEQKEVERVNALNDVASILARRVAVEFSDSESASESECESDGWGEQDSSIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HDQ4</accession>
    <name>A0A8J2HDQ4_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to CG33090: Non-lysosomal glucosylceramidase (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS7388</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5094062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HDQ4"/>
    <dbReference type="OrthoDB" id="730489at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006775">
        <property type="entry name" value="GH116_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024462">
        <property type="entry name" value="GH116_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052566">
        <property type="entry name" value="Non-lysos_glucosylceramidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12654">
        <property type="entry name" value="BILE ACID BETA-GLUCOSIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12654:SF0">
        <property type="entry name" value="NON-LYSOSOMAL GLUCOSYLCERAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04685">
        <property type="entry name" value="DUF608"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12215">
        <property type="entry name" value="Glyco_hydr_116N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycosyl-hydrolase family 116 N-terminal" evidence="2">
        <location>
            <begin position="78"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl-hydrolase family 116 catalytic region" evidence="1">
        <location>
            <begin position="441"/>
            <end position="517"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5094062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="527" mass="61179" checksum="61A636485C2FDEB4" modified="2022-05-25" version="1">MSEISNECKKVPRYGLIMPIDHKYPEQWKQTLRVRWREVLKLFGLGFRFRSYCSQVSREGRIPLMDYSNLVNDRQIYGVPIGGIGTGSIGRGFNGEFCRYALIPGIYKYETALANQFIVTVRNTDGKTIYHQVLSPLSRGKYLSSWKWGFNGKNAKYTGLFPRAWTEYDIKELNVKLICRQISPVIPNNYKDSSLPCAAFIWEIINESNVDLDVSITFTFQSGMGGSSIPGEKWTECFEYKNEVRGVMIHQELKGMPCTYAIASKASTTSDVDISRTLIFDPFGDGSELWELLERTGKLNTSATRLKSSPTLKHVGCAVCSSLRVQANNSREIEFCLAWDIPKVQFHFKLRQYLRYYTKYFYNDKETVVKEISHYTLMNYNSWEHDIYNWQRPVLDDIDLPDWYKSALFNELYYIVDGGTVWLRADETDKFKNSDPRNEYGRFAYLEGHEYRMYNTYDVHFYASFALAQLWPNLQASLQYDIRDAIQIEDSSLRTTFYDGTKSIRKAKGFVPHDIGDRSQCILIMLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HDS5</accession>
    <name>A0A8J2HDS5_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Similar to mlec-a: Malectin-A (Xenopus laevis)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HICCMSTLAB_LOCUS5753</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the malectin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5090803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HDS5"/>
    <dbReference type="OrthoDB" id="10013439at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.430">
        <property type="entry name" value="Galactose-binding lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021720">
        <property type="entry name" value="Malectin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039155">
        <property type="entry name" value="MLEC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13460:SF0">
        <property type="entry name" value="MALECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11721">
        <property type="entry name" value="Malectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="248"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="Malectin" evidence="12">
        <location>
            <begin position="30"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="209"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF11721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAG5090803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="269" mass="30371" checksum="254DEA832B34815A" modified="2022-05-25" version="1">MRIQEILNFKYVFLLLMLFEYITQGFGLEVIYAINAGGETFTDSFGIKYMRDPLMGKVGTASDYGKQLIIGRISPADQTLYQTERYHHSTFGYDIPINEDGKYVMILKFCEVYFNSPNMKVFDVVLNGDHTVVTDLDIFEKVGRGVAYNEYIPFTIQKGKLIYNDEESDILGGKIRVEFIKGYRDNPKINAIAVIKGVLDDVPKLGPIPPEPEEYHGVQEGEEESPIKARHPSGPRTPDPYSIDDSSIMLPVFVAIGAFIPLLFCLCKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HE35</accession>
    <name>A0A8J2HE35_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS5979</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5092210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HE35"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5092210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="144" mass="16464" checksum="18B8179400080616" modified="2022-05-25" version="1">MDPVFVRLVSHSCLQGTRKTLENWFLRQGFCKNTNLTKLSSNFRLELILLVKTNRSKRPVPSLNKLAVKLKVQQLSTMGLLSSKFPQRLFRTIQGGCLQRCQVPIDSSSCDEENRRKNFMMVCIIHTGANKYYVKASVQKLIAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HE81</accession>
    <name>A0A8J2HE81_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS8309</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5096637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HE81"/>
    <dbReference type="OrthoDB" id="8191899at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="206"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="159"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="212"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5096637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="232" mass="27191" checksum="317F30723F785401" modified="2022-05-25" version="1">MHTICSRNLSGSRNGISNSDLDYESPRPKKQVSHSFYGRTQDDDHDDNEETVYDIWGQRTNRLKLRNDVSNEIASATQRFKDQATNLSQNTDHTSELKHSIQQQFYNIEDKVSKNFKYSRDDNNFIPFQRYSDNMLECKREHIPPTKWSKLVTPDSDTCSNATIRVRQTKARLEDLENEIEELAERQAQRERRAVALKAFVSENTSSSQFLERNEQSHTFKCSEKKEKNVNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HED0</accession>
    <name>A0A8J2HED0_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Homeotic protein spalt-major</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">HICCMSTLAB_LOCUS7799</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Required for the establishment of the posterior-most head and the anterior-most tail segments of the embryo. Probably function as a transcriptional regulator. Could repress the transcription of the tsh gene.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the sal C2H2-type zinc-finger protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5095619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="8749569at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048731">
        <property type="term" value="P:system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002027">
        <property type="entry name" value="Blast:Sal-like protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001818">
        <property type="entry name" value="GDNF-inducible zinc finger protein 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000708">
        <property type="entry name" value="Sal-like protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000025">
        <property type="entry name" value="Spalt-like transcription factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000215">
        <property type="entry name" value="Spalt-like transcription factor 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000130">
        <property type="entry name" value="Spalt-like transcription factor 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000291">
        <property type="entry name" value="Spalt-like transcription factor 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051565">
        <property type="entry name" value="Sal_C2H2-zinc-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23233:SF84">
        <property type="entry name" value="FI23031P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23233">
        <property type="entry name" value="SAL-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 14" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="428"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="456"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="1005"/>
            <end position="1032"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="1033"/>
            <end position="1060"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="1065"/>
            <end position="1092"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="1462"/>
            <end position="1489"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="1681"/>
            <end position="1708"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="1709"/>
            <end position="1731"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="211"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="510"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="583"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="740"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="850"/>
            <end position="906"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1173"/>
            <end position="1245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1272"/>
            <end position="1348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1365"/>
            <end position="1399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1515"/>
            <end position="1547"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1596"/>
            <end position="1680"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1822"/>
            <end position="1918"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="24"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="45"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="79"/>
            <end position="110"/>
        </location>
    </feature>
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        <location>
            <begin position="123"/>
            <end position="133"/>
        </location>
    </feature>
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        </location>
    </feature>
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    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="287"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="15">
        <location>
            <begin position="515"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
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            <begin position="599"/>
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        </location>
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        <location>
            <begin position="650"/>
            <end position="673"/>
        </location>
    </feature>
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        <location>
            <begin position="674"/>
            <end position="696"/>
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    </feature>
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        <location>
            <begin position="748"/>
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        </location>
    </feature>
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        <location>
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    </feature>
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        <location>
            <begin position="799"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="860"/>
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        </location>
    </feature>
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        <location>
            <begin position="878"/>
            <end position="889"/>
        </location>
    </feature>
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        <location>
            <begin position="894"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="1187"/>
            <end position="1208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="1313"/>
            <end position="1323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="15">
        <location>
            <begin position="1324"/>
            <end position="1341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="1609"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="15">
        <location>
            <begin position="1632"/>
            <end position="1656"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="1852"/>
            <end position="1866"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="1882"/>
            <end position="1897"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="1901"/>
            <end position="1912"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00038474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00056983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00071947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CAG5095619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="1918" mass="206672" checksum="631EA442A69FD941" modified="2022-05-25" version="1">MQLMRWSITRGLENRNIKRRDSKNWQQDSNGINQSRLPSPRYSGTEDDNETGSEGEDSSGGVNVSESAVDLTSNRSHFEDEDEREPDELPMEEDDEEVVDEQEDQDEDEEGSRKQIRNRQDAENNNSFIESGTTSGLFAVPAGTSHVTLEALQNTKVAVAQFAATALAGGADSEAALQDLALLQSTLYTLQHQQVFQLQLISQLQQQLSITHTGGPGQPGAVPAGVVPGESITEPKELSTPPSPSLHHQKSSISISSLNSPPSSRPASHHPPSSPLNVPVVCHPERPSGSTSTSPISLTIPTVPGIVNSTSTSVPSSTSAITCTTASNNCTIGQTPVLSQHQMPALCSISSSLASSIITNNDPMPLNEPNTLEMLQKRAQEVLDNASQGLLANNLADELAFRSGKSGSRLSPYDSKSGGGRGEPFFKHRCRYCGKVFGSDSALQIHIRSHTGERPFKCNVCGSRFTTKGNLKVHFQRHTAKFPHVKMNPNPVPEHLDKYHPPLLQQLAASGQRPLPSPPPPSAAPPTAGSVPSPHHASFHPASTHGFLPPPHHPQPSLPLSLALPAAAAAAAAAAGMPPTLYHRGPIVNQRDDQDLPENLSKSTTTASTTTTTTTNNNKKNNNNSNNINNNNDNNNIYSNSNNDNNISNVPPPPPPPPPLPPLSLPPLLPSQPPIVSISTATTTMTTTTAASTSTSPSMLMHSPKSPVNTNNASIITNAIFSQNSSHLAHPCLIDRQREEMKREQLSPPLQSNRPDDNTSQGPDDLTTATMTETTMTQTTTATTTTPQPTIMPKREPEDPTDEDQPEDEIDEFDPPSPRRYLDRSSPLMMSNQNVMGMAHLQSYEDCSMDSKMSGRLEPDGDMDGDEEMEEQPENLSGRGSNMCHQQSVGYHHPGASPASSTASSGSLQTSFAGLLFPTAPPGHHQHMPPFIPTSSSITHGTNIPGHESMIIDPSKDPAIYSNLLPRPGSNDNSWESLIEITKTSETSKLQQLVDNIEHKLTDPNQCVICHRVLSCKSALQMHYRTHTGERPFKCKICGRAFTTKGNLKTHMGVHRAKPPLRVLHQCPVCHKKFTNALVLQQHIRLHTGEPTDLSPEQIQAAEVNDFPPGYPPHPLASFLPQGFPGLHHHPAGGGFTLGFPPTRHPALERHLHDNDMDIKDMNIYHAKNLQFHNPFQHPRGSYLDEHSEDMEDQDEDDEDRRDDDERSEDLRERMNRRPSTTDIEDDNDVNERDETKESPSMIMPPCFSTSLAALENQVRTITTVATGGLAMPGGLATPGSTSPLDRYHCSEKSTSPSSSIAGGPLDLTPRASSTPGSVVSTSTPPPPLPTPLSLPPPPPTLQHHPHPFGMFAGLLQAVTSSPSSSVQVNNTTTTTTTVNSSTNLNIVNTNSNSNSNSIQTTTSGVTINNVSTSIKAVSPSGNSSTGGGALASLTTSAVLAASSTYNPLGLAVGGPAVRGNTTCNICYKTFACNSALEIHYRSHTKERPFKCTICDRGFSTKSDDTMIRTCNCSETQEPEVKPKRNRRRRTEEKKSRGWSSGNGGRWALTSTCAPTASVHLPPLMPPALGLLTSDHVFLGNMKQHMLTHKIRDMPAHLFTDGKPPGSQPPSQHLLQDQENSQSSLINDDSSLPPPPPPPPPPPPPPIPPPMPPVESMPPIKRSPPEGDLPAPKRPSMSSKHLCQVCNKNFSSSSALQIHMRTHTGDKPFRCTVCQKAFTTKGNLKVHMGTHMWTNGASRRGRRMSLDLPPLPITPKDSEFLQRRPDLFYPYLPAPFLNGVQQKLNEISVIQSNNGLPGTHPVNASKYAGLFGTMYGGAPGGFPMEKPPMAPSNGPMGDGKPVIPSGSMLFQTPSPSHSPGTPSSNTGNQNSASVPAWSGESLQHHFDREGPSSRSENDSTPPAARMPASAPRGEGLAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HFH2</accession>
    <name>A0A8J2HFH2_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Similar to zag-1: Zinc finger E-box-binding homeobox protein zag-1 (Caenorhabditis elegans)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HICCMSTLAB_LOCUS8866</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5097765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HFH2"/>
    <dbReference type="OrthoDB" id="10004641at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000145">
        <property type="entry name" value="Zinc finger protein 574"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-0371">Homeobox</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="16"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="45"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAG5097765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="77" mass="9089" checksum="DF8429C2A59FA4C0" modified="2022-05-25" version="1">MNISWAFPETSSYGLYSCPKCTRTYSHKCTLMRHLRLECGVGPRFQCSLCEKKFKHRHHLRDHEKTHSQHSNLTAQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HG74</accession>
    <name>A0A8J2HG74_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Similar to Venom metalloproteinase 3 (Eulophus pennicornis)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HICCMSTLAB_LOCUS7567</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5095154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="7695528at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006509">
        <property type="term" value="P:membrane protein ectodomain proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1620.60">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041645">
        <property type="entry name" value="ADAMTS_CR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001590">
        <property type="entry name" value="Peptidase_M12B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11905">
        <property type="entry name" value="ADAM A DISINTEGRIN AND METALLOPROTEASE DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11905:SF249">
        <property type="entry name" value="SOL NARAE, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17771">
        <property type="entry name" value="ADAMTS_CR_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01421">
        <property type="entry name" value="Reprolysin"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13688">
        <property type="entry name" value="Reprolysin_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50215">
        <property type="entry name" value="ADAM_MEPRO"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <keyword evidence="4 8" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035208409" evidence="10">
        <location>
            <begin position="19"/>
            <end position="2210"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M12B" evidence="11">
        <location>
            <begin position="196"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M12B" evidence="11">
        <location>
            <begin position="636"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M12B" evidence="11">
        <location>
            <begin position="954"/>
            <end position="1174"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M12B" evidence="11">
        <location>
            <begin position="1309"/>
            <end position="1501"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M12B" evidence="11">
        <location>
            <begin position="1574"/>
            <end position="1785"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M12B" evidence="11">
        <location>
            <begin position="1859"/>
            <end position="2081"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="24"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="349"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="795"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="1112"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="1440"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="1724"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="2020"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="348"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="352"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="358"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="794"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="798"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="804"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="1111"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="1115"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="1121"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="1439"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="1443"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="1449"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="1723"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="1727"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="1733"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="2019"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="2023"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="2029"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="812"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="1700"/>
            <end position="1780"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAG5095154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="2210" mass="251612" checksum="7665E2586D520A1A" modified="2022-05-25" version="1">MRFSVVFIGLLLLLEVSARQNEERNYGSFGRRPSTHLRSPQNNRPSYATVPNNPSLDRRIRNRRISFRRIKSWLDPRHGVLFNLDTPVYSVRNTNRALHPEIEEYPNVFRHVISNLYEDIASASVPEIIKRNYYRALTNNIRRPVPPRFRRPQIYVPKTIPFNRNGRLNIVSITNNSFDSSFTSSPRPKLVTPSIIHPEVLVIVDYALYKKFHRSVWELVNYLMGFWNGVDFRFRDFNHPHVRLSIVGILIAEDEKALNYIYRNREGRDAVNGNKLVNDKRSWLYEQRAKFPFTSYDISITMTGLKTDMKGLASIAAACRVNHDTKVVYQTGFVSDYGGYDAIMAAAHEIGHLLGMTHDNKKDGKCGFDDGYIMAPILKSKNTSWSWSPCSHSDFDNFISWENKTCLYNKPRTNGVLPRLLPGKLLDGDEQCKRAGFLKAVLDEKTCLKLECVVESGELEVHRISSDGAADGTTCGEGKICLRGLCRLERSPFGEHIKMWLNPVDGILAGEDLPIYTLSSDPNNRSKVKTEKHVGYMKYALSKLYENTLHATTLAINYHPDGKKSMTGFIGNSYIRPVLSEMINQVKRYRRALNDTDHLDNKIYHIIQKIPESELKKELPLKIIKSRSRRSYPTVLYPEVLVIVDYSLNRKFGGNIKEILVYLLSYWNGVDMRFRGIENPKIRLNIAGIMFAQDPWGLSYIKNYIEGNRVNDYISKIESKGRWLYRMNSVIPIDSYDVAVTMMTHKMCDYQECAILGVSPVGSACHVDHAHQTMHKILIVRDTGAYEGISSTVHELGHAFGMNHDGQINRGCPSQNGFIMAPSDVHTLQQFDWSLCSLIDLQNFVKMNPKCMLNKPHQGKQLQRFLPGKLMDANKQCQMLNALRAFVINDSICLRLQCVFGINALFSDYLIKSLLPQMYENTLYATTIAVNNHSLGQSLASKISRSKNLYPNVIYPEILIIADYNFLKKFEKIEDAVMYLLTFWNGVDMRYRSLEHPKVRLNIAGIVVAQDPFVLRCMNIVNEKLMGSSNILSAMGKWLYFMYKWIPITSYDIAVTMSPFELCEYESLCGILGQVAEVGAACHVSKKHQTTKKVAIIRDRAAFDGVNTAAHELGHMFGMMHDGQFNRKCSEKHGFIMSPTNQHSKYSFEWSKCSLTDMQRFLTNSRASCLENKPNQGKAIERYLPGKLMDADQQCKFMKAAWLNPMDGILAGDKTPVHFLAENPQNRYYPKVLTARDVSFFMKFVSVNNRKINSNMLKQILPKLYENHLHATTLAVNRHSNGKRKAFTNSSRSRRSSENDEVRIYPEIIYPEIFVIVDYPLLNQFKSQWIELLVYILTFWNGVDLRYRDIVHPRVRFNIHSIAICVKPNVLPYLQAYGNGQGVDVNRSLNAKADWLKRMTNADGCNVLGVANLKGACTNDNVALVKDTGGFGGIMTTAHELGHAFGMKHDDQAERNCNDKVGNVMAPVKTNTPNSYVWSYCSLRDFQDFIVQHGDCLDNPPAQQKPLYKFMPGMLMDANKQCEMLLGRGVKAYRIDDSICTQLQCTARTNYPLPEAADGTTCGRGKMCLHGLTIYPEILLIVPLTLSQKIGNGDANILAYLLSYWNGVDMRYRSLENPRIRLNIAAIVFAEDHYVLPYMTTENYVMQDSVGKLERKRIWLNELHRYFALNYDLAVTMLPYVMCGDNGCGTFGLAYPGGACSVYNKVAFVTDRGAYDGIQSTAHELGHLFGMVHDGEQNKCQDSDGYIMTRWDKYSSHSFDWSPCSLQKMDTFLKSKGSWCLKNHPNQGRKIPRYLPGKRMDANQQCKQLVNGVATYIGDSICTQLKCLIQYNFALPEAAEGTVCGYRKLCLHGKFPEVIYPEILVIVENSLMRLMGETPDQQLLYVLAFWNGVDMRYRTLANPRVRLNIAHIIFAEDNDVLTYLNPQNSRYFVLNNDNAIANQGRWLYQIQRQVPLASYDLAITMLPHLMCANNPNSCNTLGFAAISGACSTDYQHGITYKVGYVLDRGGYDGIQTAAHELGHLFGIQHDGERNGCHDQHGYIMTTFDKFTPQAFDWSPCSLQYMDQYLKSGKGWCLYNYPFYDKPFQRYLPGKLMDANRQCRILRKGYATVIDDSICTQLKCNGIHTDVRLPEAAEGTPCGQGRLCLHGRCDYENGVIIASETIKISYSSVERECAINLLNCIYNARRTIDLTVSFYRCDDNSESLVIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HID9</accession>
    <name>A0A8J2HID9_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Endonuclease/exonuclease/phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS8358</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5096734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HID9"/>
    <dbReference type="OrthoDB" id="7701337at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14529">
        <property type="entry name" value="Exo_endo_phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="2">
        <location>
            <begin position="58"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5096734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="327" mass="37215" checksum="DCA3D5209E35C804" modified="2022-05-25" version="1">MVGNRCDKKNSKSRGRASGGHLLGIKKRVEKKWRVNEWGYGFKIAKENENRNDTEAMIISVYNNVGIKKIESELKGVVEENARTAEKIIIVGDLNARVGERNTEGVKEEERLKRKSKDKVLNSEGKKLLKVCKELGLRIMNGGTEGDRKGEITFIGGKSENCGSVLDLVLTLDRGGDSGISYLKISESIDSDHLPLILNLNEKDKAKAGAKRQGSESDHIAQEEGAIKIEEDILGWKKDKIAEYQEVIWEKWNEKITERETELEWNDMKEIIYNGAKETGMSKKRKECDKADKTKKEWFNNECKLKREEVWKALKKLTNEKDSNNKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HIP3</accession>
    <name>A0A8J2HIP3_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS8512</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5097041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HIP3"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5097041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="103" mass="12721" checksum="384FBB87DC4DD122" modified="2022-05-25" version="1">MNFNTINMIMNRGFLNPYNCRYDFNFRYPQLYEEPFVRFRYLYDCYPFYHNSYLRTDHHVINSPSFWEKRYQVLLGFKSISFNVKVKTVGKNTQWFKPLITVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HJ68</accession>
    <name>A0A8J2HJ68_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS8874</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5097781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HJ68"/>
    <dbReference type="OrthoDB" id="10004641at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="230"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5097781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="330" mass="39157" checksum="6E7E83D28781ABB3" modified="2022-05-25" version="1">METSFDYFPGYEETFPVKEEDDLNQLMIKNIKFACNNPKCNLTFNSERQRDKHSFDCLKNNLKPEKIALDQSAKFRDEFKENKEKIPSKNPVKPLKPKKTSKKIVQRYKIIEGRYFCCKCSRSYTNELTTMKLSFNDFPSQEETFSVKEDDDLNQLMIKNIKYACNNLECNLTFSREHQRDKHSFDCLKNNLQPEEITFDQRNYPLTVRRFDDYYSGLQNFHSNMNLNKYPCVNAHCNSVFKDENTLRKHVKYICGKPPRYQCGYCEYRSHWAPNVRTHSKALHPDLMTDVIELYNPYPEEMGTFVCPNCSQRYKFKKGLDAHLKNLCGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HK46</accession>
    <name>A0A8J2HK46_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Odorant receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HICCMSTLAB_LOCUS9007</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Cell membrane</location>
            <topology evidence="1 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the insect chemoreceptor superfamily. Heteromeric odorant receptor channel (TC 1.A.69) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5098048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HK46"/>
    <dbReference type="OrthoDB" id="7179992at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005549">
        <property type="term" value="F:odorant binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004984">
        <property type="term" value="F:olfactory receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004117">
        <property type="entry name" value="7tm6_olfct_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21137">
        <property type="entry name" value="ODORANT RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21137:SF35">
        <property type="entry name" value="ODORANT RECEPTOR 19A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02949">
        <property type="entry name" value="7tm_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 10" id="KW-0552">Olfaction</keyword>
    <keyword evidence="8 10 11" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="9 10" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="37"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="64"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="126"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="242"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU351113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAG5098048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="369" mass="42162" checksum="72CF3EA60D3D1E71" modified="2022-05-25" version="1">MRFNVQVTLKRAIKFTKLTVFLTCAWPPRKRLFLFKIFMCFSVFLSIALLLPLIVSIIQHSDNFFIIIKSVIFICGIVNYVAKVITVRIYHEELQELRSIVDKFVDKANDQEKIVMQKLIDKCWKFQFFMTCSYYLTTTAILIGPLVLPQKFPTDAVYPFSVDNPVISRIVYLHQCFVGYQCSAGMALDCQAALFIWFLSAKFELLGAESKSVVNHDQLCHFVEKHQDLLIFADKLILPTRIMAFSTVSVTKIGMIFGGIFLISNEPLAVKVQFGIMVMSTTANIYVCSWAADYLITVSSSTLSEEIFGSSWKHEPKVRKMWSIVLLRSQKPVVINIPGLLNNLSNEYYAAVSLFSITYNIKIRLTINN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HK63</accession>
    <name>A0A8J2HK63_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HICCMSTLAB_LOCUS7187</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5093861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HK63"/>
    <dbReference type="OrthoDB" id="6361927at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="98"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="234"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG5093861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="269" mass="29612" checksum="21FDFCDBB68234F8" modified="2022-05-25" version="1">MRVVTRQEVLMIPLVIHRTLSCNYLATTSLNPSIGLMSLPVENGPSVQVPRSLMQAFLKQDPNHPGLETVRLPNPLVGNEEPSPLPPYCREIESEVCLVCRRCGRAYPQESSLLTHQRSCYLGNQQRRGALRLVQARFSCSLCDTAASTRTYGTLNEWRRHAETVQHRARLESLQIQQRTSGSSNFGQFSSPDFNLGLNLGQDATDEEANPLVDEMEDVVNQITLLAARAAAESTSTSTPSAVVSQDNNNGEAKRQKLVQEVAALAGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HKP8</accession>
    <name>A0A8J2HKP8_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">General transcription and DNA repair factor IIH helicase subunit XPD</fullName>
            <ecNumber evidence="18">5.6.2.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="21">CXPD</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="22">DNA 5'-3' helicase XPD</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="20">DNA excision repair protein ERCC-2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="23">DNA repair protein complementing XP-D cells</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="24">Xeroderma pigmentosum group D-complementing protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="28" type="ORF">HICCMSTLAB_LOCUS10371</name>
    </gene>
    <organism evidence="28 29">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="28" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="30">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the helicase family. RAD3/XPD subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="28">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.3" evidence="18"/>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5101298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HKP8"/>
    <dbReference type="OrthoDB" id="272481at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016818">
        <property type="term" value="F:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035315">
        <property type="term" value="P:hair cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045951">
        <property type="term" value="P:positive regulation of mitotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18788">
        <property type="entry name" value="SF2_C_XPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000135">
        <property type="entry name" value="DNA repair helicase RAD3, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000128">
        <property type="entry name" value="Putative DNA repair helicase RAD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000381">
        <property type="entry name" value="TFIIH basal transcription factor complex helicase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006555">
        <property type="entry name" value="ATP-dep_Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045028">
        <property type="entry name" value="DinG/Rad3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010643">
        <property type="entry name" value="HBB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014013">
        <property type="entry name" value="Helic_SF1/SF2_ATP-bd_DinG/Rad3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006554">
        <property type="entry name" value="Helicase-like_DEXD_c2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010614">
        <property type="entry name" value="RAD3-like_helicase_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013020">
        <property type="entry name" value="Rad3/Chl1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001945">
        <property type="entry name" value="RAD3/XPD"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00604">
        <property type="entry name" value="rad3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11472">
        <property type="entry name" value="DNA REPAIR DEAD HELICASE RAD3/XP-D SUBFAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11472:SF1">
        <property type="entry name" value="GENERAL TRANSCRIPTION AND DNA REPAIR FACTOR IIH HELICASE SUBUNIT XPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06733">
        <property type="entry name" value="DEAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06777">
        <property type="entry name" value="HBB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13307">
        <property type="entry name" value="Helicase_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00852">
        <property type="entry name" value="XRODRMPGMNTD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00488">
        <property type="entry name" value="DEXDc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00491">
        <property type="entry name" value="HELICc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51193">
        <property type="entry name" value="HELICASE_ATP_BIND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="25" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0227">DNA damage</keyword>
    <keyword evidence="15" id="KW-0234">DNA repair</keyword>
    <keyword evidence="14" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10 28" id="KW-0347">Helicase</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0408">Iron</keyword>
    <keyword evidence="13" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="16" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-0539">Nucleus</keyword>
    <keyword evidence="29" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="27">
        <location>
            <begin position="1"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="26">
        <location>
            <begin position="720"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="25">
        <location>
            <begin position="232"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="26">
        <location>
            <begin position="720"/>
            <end position="738"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00044969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00048954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00078828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00079246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00081072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00081188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00082576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="27">
        <source>
            <dbReference type="PROSITE" id="PS51193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="EMBL" id="CAG5101298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="747" mass="85357" checksum="5C45507B8ED49954" modified="2022-05-25" version="1">MLELKRGLDARGHCLLEMPSGTGKTVTLLALIVAYMLENPSSVTKLIYCSRTVPEIEKVIEELKKLMDYYEKETGSPPRMVGLVLSSRKNMCIHPEVSKERDGKIVDGRCHSLTASYVRARHNYDDTTPICSYYEGFDEEGRERVMPPGIYSIDDIKDYGRDRNWCPYFLARLAIVQAQFVVYSYHYLLDPKIAQTVSKELAKNSVVVFDEAHNIDNVCIDSMSVKITRKTMEKCTANIQLLEKTVSEMRAEDANKLKEEYQRLVEGLKDAQVSRETDVVLANPVLPDEILEEVIPGNIRNAEHFVSFLKRFVEYLKTRLRVQHVVQETPALFLRDLQTKVCIERKPLKFCAERLASLLRTMEITDLTDFSALILVTHLATLVSTYATGFTIIVEPFDDRTPTVLNPILHFSCMDSSIAMKPIFDRFQSVIITSGTLSPLDMYPKILNFHPVIMTSFTMTLARPCLLPMIVSKGNDQVAISSKYETRDDVAVIRNYGQLLVEFAAIVPDGLVCFFTSYLYMESVIAAWYDQGVVDQLQRHKLLFIETQDSAETSLALVNYIKACDSGRGAVLLSVARGKVSEGVDFDHHLGRAVLMFGIPYVYTQSRILKARLDYLRDQFQIRENDFLTFDAMRHAAQCIGRVLRGKTDYGIMIFADKRFSRADKRSKIPKWIQEHLSDSLCNLSTEEAVQISKKWLRQMAQPFSREDQLGLSLLTKEQVEKKEAKKKEEEEARKLEMEIEMEDDIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HLB3</accession>
    <name>A0A8J2HLB3_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to rost: Protein rolling stone (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS12616</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5107172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HLB3"/>
    <dbReference type="OrthoDB" id="419711at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049352">
        <property type="entry name" value="Rost"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12242:SF49">
        <property type="entry name" value="HEADBUTT, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12242">
        <property type="entry name" value="OS02G0130600 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21534">
        <property type="entry name" value="Rost"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="92"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="134"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="177"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="212"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="238"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="278"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="313"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="329"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5107172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="339" mass="39301" checksum="55BFF6747AB81903" modified="2022-05-25" version="1">MERQSNEQQQIPPGIHIDTSEFSSVQLCINPTEKKKKDSFCLSTSFCGPRAMVNKLWCRKISRAWLETKQTPPHPRLLTESRFKTYAPWWYVYYRWFMSLGWISIVICSVWEIGSTDPLASKYGSRKWFAYLTNWHLTFGVAQTILGATLVTRRWLHQRYPDFNPYNIKYTCLEKSYWFLYSVTASLAIGVTAAYWIAIYDPKIHFVDSVNLMQHALNSILIIVDLFICAVPIRLRCFWWTVVVIVIYLIFSVIYYSAGGLDRKGFHYIYKILDWKKPGISLLVSLGGIGFIIIVHCLLTGLTSCLERITKPSDKSIHEPPLSSANNEQRTKVRDVEIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HLC2</accession>
    <name>A0A8J2HLC2_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Similar to RPS27: 40S ribosomal protein S27 (Homarus americanus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HICCMSTLAB_LOCUS10939</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic ribosomal protein eS27 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5102286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HLC2"/>
    <dbReference type="OrthoDB" id="74314at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.100:FF:000001">
        <property type="entry name" value="40S ribosomal protein S27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.100">
        <property type="entry name" value="Zn-binding ribosomal proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00371">
        <property type="entry name" value="Ribosomal_eS27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000592">
        <property type="entry name" value="Ribosomal_eS27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023407">
        <property type="entry name" value="Ribosomal_eS27_Zn-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11594">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01667">
        <property type="entry name" value="Ribosomal_S27e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="Zn-binding ribosomal proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAG5102286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="85" mass="9697" checksum="0C5CAA89563FBB0D" modified="2022-05-25" version="1">MPLAVDYLHPSPQEEKRKHKLKRLVQKPNSYFMDVKCPGCYAIKTIFSHAQRPVECDGCRTILCTPTGGKARLTEGCSFRRKVQC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HM28</accession>
    <name>A0A8J2HM28_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Very long-chain specific acyl-CoA dehydrogenase, mitochondrial</fullName>
            <ecNumber evidence="16">1.3.8.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="30" type="ORF">HICCMSTLAB_LOCUS10763</name>
    </gene>
    <organism evidence="30 31">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="30" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="18">Very long-chain specific acyl-CoA dehydrogenase is one of the acyl-CoA dehydrogenases that catalyze the first step of mitochondrial fatty acid beta-oxidation, an aerobic process breaking down fatty acids into acetyl-CoA and allowing the production of energy from fats. The first step of fatty acid beta-oxidation consists in the removal of one hydrogen from C-2 and C-3 of the straight-chain fatty acyl-CoA thioester, resulting in the formation of trans-2-enoyl-CoA. Among the different mitochondrial acyl-CoA dehydrogenases, very long-chain specific acyl-CoA dehydrogenase acts specifically on acyl-CoAs with saturated 12 to 24 carbons long primary chains.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>a very-long-chain 2,3-saturated fatty acyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = a very-long-chain (2E)-enoyl-CoA + reduced [electron-transfer flavoprotein]</text>
            <dbReference type="Rhea" id="RHEA:19181"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="ChEBI" id="CHEBI:83724"/>
            <dbReference type="ChEBI" id="CHEBI:83728"/>
            <dbReference type="EC" id="1.3.8.9"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="22">
            <dbReference type="Rhea" id="RHEA:19182"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>dodecanoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E)-dodecenoyl-CoA + reduced [electron-transfer flavoprotein]</text>
            <dbReference type="Rhea" id="RHEA:47296"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57330"/>
            <dbReference type="ChEBI" id="CHEBI:57375"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="20">
            <dbReference type="Rhea" id="RHEA:47297"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>eicosanoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E)-eicosenoyl-CoA + reduced [electron-transfer flavoprotein]</text>
            <dbReference type="Rhea" id="RHEA:47236"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57380"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="ChEBI" id="CHEBI:74691"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="23">
            <dbReference type="Rhea" id="RHEA:47237"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="24">
            <text>octadecanoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E)-octadecenoyl-CoA + reduced [electron-transfer flavoprotein]</text>
            <dbReference type="Rhea" id="RHEA:47240"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57394"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="ChEBI" id="CHEBI:71412"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="24">
            <dbReference type="Rhea" id="RHEA:47241"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>tetracosanoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E)-tetracosenoyl-CoA + reduced [electron-transfer flavoprotein]</text>
            <dbReference type="Rhea" id="RHEA:47232"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="ChEBI" id="CHEBI:65052"/>
            <dbReference type="ChEBI" id="CHEBI:74693"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="21">
            <dbReference type="Rhea" id="RHEA:47233"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 25">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism; mitochondrial fatty acid beta-oxidation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="19">Homodimer. Homodimerizes after import into the mitochondrion.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 25">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="30">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.8.9" evidence="16"/>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5101934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HM28"/>
    <dbReference type="OrthoDB" id="2588832at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000062">
        <property type="term" value="F:fatty-acyl-CoA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017099">
        <property type="term" value="F:very-long-chain fatty acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.110.10:FF:000006">
        <property type="entry name" value="very long-chain specific acyl-CoA dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.540.10:FF:000001">
        <property type="entry name" value="Very long-chain-specific acyl-CoA dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="entry name" value="Acyl-CoA dehydrogenase/oxidase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049448">
        <property type="entry name" value="ACAD9/ACADV-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006089">
        <property type="entry name" value="Acyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43884">
        <property type="entry name" value="ACYL-COA DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43884:SF11">
        <property type="entry name" value="VERY LONG-CHAIN SPECIFIC ACYL-COA DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21343">
        <property type="entry name" value="ACAD9-ACADV_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00073">
        <property type="entry name" value="ACYL_COA_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 25" id="KW-0274">FAD</keyword>
    <keyword evidence="10" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="6 25" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="13" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12 25" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="31" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0702">S-nitrosylation</keyword>
    <keyword evidence="11" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase N-terminal" evidence="28">
        <location>
            <begin position="75"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA oxidase/dehydrogenase middle" evidence="27">
        <location>
            <begin position="188"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase C-terminal" evidence="26">
        <location>
            <begin position="302"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase C-terminal" evidence="26">
        <location>
            <begin position="367"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="domain" description="ACAD9/ACADV-like C-terminal" evidence="29">
        <location>
            <begin position="476"/>
            <end position="592"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00039034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00040902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00045422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00046812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00047893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00048086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00049050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00049140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00049224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="27">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="28">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="29">
        <source>
            <dbReference type="Pfam" id="PF21343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="30">
        <source>
            <dbReference type="EMBL" id="CAG5101934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="31">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="601" mass="65862" checksum="7A0A0FE7517F3EB9" modified="2022-05-25" version="1">MLSVSKIISLTPKHFNKFVKLNTRCLATQTAAKENPAKETKEKKESLSFTMNLFRSQLQLEQVIPFPKALNSDQSETLKMLVDPFSNFFAEVNDPVKNDDTADVDDKIKQTLWDLGGFSIQVPEKYGGIGLNNTQYARLVEIVGQNDLGVGIMLGAHQSIGFKGILLYGTPEQKEKYLTRVSNGEYAAFALTEPSCGSDAGSVKTRAVKSADGTHYVMNGSKIWISNGGWANIFTVFAKVPMKDPVTGETTEKVTAFIVDRAFGGVTNGPPEKKMGIKCSNTAEVFFEDVKVPAENVLVGEGQGFKVAMNILNNGRFGMVAALSGTMQSCIKKAVEFANQRVQFGKTINQYGSIQEKIARMSMHQYVFASESAWYVCDEAIQILGGMGYMKDTGLERVMRDVRIFRIFEGTNDILRLFVALTGIQHAGGHLQELQRAFKNPAANLGLIFEEAAKRATKAVGLGSTPTFAHLLHPILAESANLTGKSIENFGQTVEGLLIKYGRGIVNEQFILNRLAQAAIDTYTSVVVLSRASQSLNNKIPSAEHESVMAKVWCSEAASRTAYNLKVVKSEKSLELFNQMKTISRNVCEVGECAQNTPLGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HM98</accession>
    <name>A0A8J2HM98_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Similar to prdm10: PR domain zinc finger protein 10 (Xenopus tropicalis)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HICCMSTLAB_LOCUS13253</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5108470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HM98"/>
    <dbReference type="OrthoDB" id="3535323at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008170">
        <property type="term" value="F:N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008276">
        <property type="term" value="F:protein methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050331">
        <property type="entry name" value="Zinc_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515:SF49">
        <property type="entry name" value="GASTRULA ZINC FINGER PROTEIN XLCGF49.1-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515">
        <property type="entry name" value="PR DOMAIN ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21549">
        <property type="entry name" value="PRDM2_PR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13912">
        <property type="entry name" value="zf-C2H2_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="12"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="588"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="619"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="659"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="752"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="782"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="811"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="840"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="868"/>
            <end position="895"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="896"/>
            <end position="924"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="1007"/>
            <end position="1035"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="1052"/>
            <end position="1080"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="1099"/>
            <end position="1123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="82"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="553"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="721"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="924"/>
            <end position="993"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1125"/>
            <end position="1151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="94"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="566"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="728"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="934"/>
            <end position="987"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1138"/>
            <end position="1147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAG5108470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="1216" mass="138144" checksum="DE67F7029B7137B4" modified="2022-05-25" version="1">MDSRGPQRAGAPVNPTTITSTIADVDKSLLDTVVDDNWHGVGSTVKNNNRLLFLTVEYVDDNQSRDYSKVFSPYEQVSFYSPRAPSPLSDFEHSQVSPLDPNMSSTARYSPTPVPQLPSLSFPNSVVVLPDPPSPLIIPSDGHARTNINNYISSHNNTIQNVVQSADNTTIDFVNTDVHEETLVTSVNGELILMQGTNVELESTSSSSSSRSADTAAAGPLMLAEIPETEFTLTRDFLVMHDEDQLNVVNSLVSQSGGIKEEQIIIGDHMIGEHQTKLLEFNNDDPIISKEQIIGKILKNNIESAKIIPSVPASGKIILRKNKKQIRNKTTSDYEECISPGCLKSGECTCRNVRTISDQPVPSRAVATLPGSYLAINKLPSTPVIGEPIGYCNYGVFAKRNIRQRTQFGPIEGVLYPYNGESFKNDQLPLLYETNEGDLLKVDVSDENTSNWMRFVRPALTYNEQNLVICQQADGIFFLTTRNILSKEELKAGPSSQYASRRGLTILESDSSLKDKEIPYDDDNNINEWQFSNACEEPFKPTEKFESLDIQYNENGADNKPDSEQNKSNSPTNNKKLLKVVDGQTVLYSCPQCTKVFPRSYSLKRHMHMHLSSKTPQKYECLTCGENFLHPYNRSRHMKIFHNDETREKENTCESSSEYKCKSCNLTFKKLSLLNIHKLIHKEDPNKDDGSSTSSLSSACPQCQVTFNAWHDLINHVSSKHGRVKLPKVSNTSKVNKNNNNNNNNQVTPPIYKCTKCYKRFATRVRLQQHYLVHGAEDQKPLPCNICCKRFMNNSALSCHLKTHRQDKQLFECPMCRKLFNQVLMLKEHIETHRGEDGIFSCPHCPRTFTKYSVIRKHIRAHHCERKHKCQVCSKPFPTIDKLRMHLLRHSDHREFHCANCGKQFKRKDKLKEHMTRMHNALKIKRDQLTTQSNNNNNNNNNNNNNNNNNNNNNNNNNNNNINKNNNNNNNNNNSNIDNNNINDNNNSQAKKFIPKVNPTDYNRFIYKCHQCLVGFKRRGMLVNHLAKRHPDVSPDSIPELNLPILRQTRDYYCQYCDKVYKSSSKRKAHIMKNHPGADSGLHNSTFSQAVGSVSTVPQSCQWCHKQYASKAKLLQHQRKKHAALLNPADKIPRPRNRSSSQQNNSSTLDDNNFIMSDYIQGYDTEVDFIKPKILKMSEDTDFIDNEDDDDDEGDDGDNHNLELAGEQFIRICDIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HMB3</accession>
    <name>A0A8J2HMB3_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Similar to Wdr19: WD repeat-containing protein 19 (Mus musculus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">HICCMSTLAB_LOCUS10899</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Cilium basal body</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5102206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10250638at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030991">
        <property type="term" value="C:intraciliary transport particle A"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008104">
        <property type="term" value="P:intracellular protein localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035721">
        <property type="term" value="P:intraciliary retrograde transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000242">
        <property type="entry name" value="WD repeat domain 19, isoform CRA_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.470:FF:000009">
        <property type="entry name" value="WD repeat-containing protein 19 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.470">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057855">
        <property type="entry name" value="Beta-prop_WDR19_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056168">
        <property type="entry name" value="TPR_IF140/IFT172/WDR19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056157">
        <property type="entry name" value="TPR_IFT80_172_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040379">
        <property type="entry name" value="WDR19/dyf-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039468">
        <property type="entry name" value="WDR19_WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056170">
        <property type="entry name" value="Znf_IFT121-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14920">
        <property type="entry name" value="OSMOTIC AVOIDANCE ABNORMAL PROTEIN 1/WD REPEAT MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14920:SF0">
        <property type="entry name" value="WD REPEAT DOMAIN 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23389">
        <property type="entry name" value="Beta-prop_WDR19_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15911">
        <property type="entry name" value="Beta-prop_WDR19_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24762">
        <property type="entry name" value="TPR_IF140-IFT172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23387">
        <property type="entry name" value="TPR_IFT80_172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23145">
        <property type="entry name" value="Zf_2nd_IFT121"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0966">Cell projection</keyword>
    <keyword evidence="7" id="KW-0969">Cilium</keyword>
    <keyword evidence="5" id="KW-0970">Cilium biogenesis/degradation</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="WDR19 first beta-propeller" evidence="13">
        <location>
            <begin position="19"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="domain" description="WDR19 WD40 repeat" evidence="10">
        <location>
            <begin position="361"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="domain" description="IFT80/172/WDR35 TPR" evidence="12">
        <location>
            <begin position="682"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="domain" description="IF140/IFT172/WDR19 TPR" evidence="14">
        <location>
            <begin position="854"/>
            <end position="1072"/>
        </location>
    </feature>
    <feature type="domain" description="IFT121-like zinc finger" evidence="11">
        <location>
            <begin position="1298"/>
            <end position="1344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF15911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF23145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF23387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF23389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF24762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CAG5102206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="1370" mass="155096" checksum="6262E7B5DD0675DC" modified="2022-05-25" version="1">MTSDKVLYKLDHPHGPGSVFISWRPGNSTHLATTGCDGVVSIYDRQGEIQERIQLMGLCSEFGWDVDGDILAVITNNSSTIILWDATTNKKSQIDAGVRDTLTCMMWAKHACILAVGTQKGNLILYDHSNARRIPILGKHKKKIVCGAWSSEGILGLAGEDRILTISTADGDTRREIQLQGDPQDLKFGEMKTDSRTSGENTISLIIGKVTLLLYNIRDPDNPIELAFQKRYGPIVTYKWYGDGYILVGFEAGYLISISTHIKEVGQELLQIKNHRDSLNDISLSLTAKKIATCGDNTLKIHGLQNIEETEKIITISGEAAVNSVEWSADGTMIAAVTHSGNVLIYLAQIPKLTSVCGNRIALLASLTEVIVYLYTLDGDKPEPQTIHTIIEPSILSVGPTHVAVAVNNRALFWNLSAGQTDRAIHIERDYLSSVESICLNETYTSVLYDGKIQLHTIKTDPALIKEEKDNKVFANPSSSNGRITCHALSAEFLVYGTDMGRIVYFCLDVFNHSTEYSHISGIKNIFMDVTGTNMCFIDDKNDIFVYNPVDERIVTVPDCPDSPEGVIWDQNIYERSIFAIYNKSFISTYIFIKYNIEGSKVVKITTTKLPSETLPLLMYGGEVTLGVAGGKLLQITLSSHENVGNIVENKKIIEILDNQINCHRYRQAWNTCLTLNDKNHWIKLGKSALENLDIEMGIRAYREIPDVSMVWALQKLENIEELSLLYGHICLLLENYNKAEKFFLESSEPVEALYLRRDLMEWEQALTLAQKFKPDEIPFISQEYAQQLELTGNYPKALINYERALSAVNENTMTTEQFYNHRMQCLSGIARTSIRCGDSRRGVAIAMENDTPRSVRKECAEILENMKQFTEAAMLYEKADYYDKAALAYIKLKNWVKVGQLLPQISAPKINIQYAKAKEAEGKYDDAARAYEIAKDYDNIIRINLEYLNNPGRSVEIVQQTKSIEGAKMVARYFQKMNDYNSAIKFLIMSNCHDEAFQLANQHGKMELYGDILVNTLDDDNVRLEDFKSLAIHFETQKNSLLAGKYYFYAKDFHKALKHLLKAAQLSTDDDAALSLAIDTIAVSKDDKLANQLIDFLLGGDGLPKDPKYLFRLYMARKQYKDAAKTAIIIANEEQVNGNYRNAHDVLFGMYQELKRNKITIPLEMNNNLRLLHSYILVRLHVKRNDHLRGARMLIRVANNISKFPSHIVPILTSTVIECHRAGLKYAAFNYAAMLMRPEYRTQVNIKYSKKIEAIVRKPPRSKDHEVEDEPLTPCPYCKNRIPETEITCDKCKNTIPFCIATGRHIIENDFTACPQCDFPAIKSEFLRIIETDELCPMCNEKVDLRMIPQNINIRIYLEMQDEQFNQIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HMK0</accession>
    <name>A0A8J2HMK0_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS11066</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5102540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HMK0"/>
    <dbReference type="OrthoDB" id="6370791at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5102540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="145" mass="16432" checksum="81351C8475B5C37E" modified="2022-05-25" version="1">MKFFEAIFTVILIADNVIGYYVVVQDQPTRQSYEEKFREFLEVKLREVMKQGDIVLGIPVLDPFVGNDKTIEYNSQNLALFSGTGIFCNNSTSIVLSQVISDVLPEIVTVYYHDNITAMASEKIIDMANEKLEGITWEDLLQLIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HP20</accession>
    <name>A0A8J2HP20_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS13202</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5108368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HP20"/>
    <dbReference type="OrthoDB" id="10341170at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5108368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="236" mass="27352" checksum="E905E8303621AB92" modified="2022-05-25" version="1">MPSKRRTKKGLSIRLRCRQMRLAKERKKLAFLKLADSIFENKNASSTPAENKSSKSNLEVPSEVDENEEEEIIYEEIEGYFPEERLEETSNIDNSEDFIGLNQSNDLNNCTKEEQEERLVIKIDPAEYLSELNQSNGSDNCSEENLNIKIEPIEDLSELNQLDNLVYCTEEKEQNVDNNSSKIHALNLPRLNKFTSNYEVKYKAVVILSHDLDYYSEEEEEIPAFNSDEIDKKIKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HP47</accession>
    <name>A0A8J2HP47_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Mitochondrial import inner membrane translocase subunit TIM22</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HICCMSTLAB_LOCUS11385</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="8 9">Essential core component of the TIM22 complex, a complex that mediates the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. In the TIM22 complex, it constitutes the voltage-activated and signal-gated channel. Forms a twin-pore translocase that uses the membrane potential as external driving force in 2 voltage-dependent steps.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the TIM22 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Mitochondrion inner membrane</location>
            <topology evidence="1 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the Tim17/Tim22/Tim23 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5103189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HP47"/>
    <dbReference type="OrthoDB" id="75343at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042721">
        <property type="term" value="C:TIM22 mitochondrial import inner membrane insertion complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030943">
        <property type="term" value="F:mitochondrion targeting sequence binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045039">
        <property type="term" value="P:protein insertion into mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039175">
        <property type="entry name" value="TIM22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14110">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14110:SF0">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02466">
        <property type="entry name" value="Tim17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4 9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0811">Translocation</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="9" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU367038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAG5103189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="195" mass="21356" checksum="64FDC965D454AF02" modified="2022-05-25" version="1">MLRFEPPKLPSPPKLKEEDQRIFLSDPTWDKIAVYFTTNHQRYRENIVIPRGPAPVHIVTNEEKAMQTFMESCVFKSIFSGVLGYGLGAALGLFSSSVNPNVAAVEQQQTARQIFREMKVTTLGYAKNFATIGLLFSAMECTVESYRGKTDWRNGTYAGGLTGGLIGLRAGVKAGVIGAAGFAAFSAAIDYYMHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HPA9</accession>
    <name>A0A8J2HPA9_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS12847</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5107645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HPA9"/>
    <dbReference type="OrthoDB" id="6424379at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="93"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="240"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="244"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5107645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="289" mass="32851" checksum="9A927B080D5373E9" modified="2022-05-25" version="1">MLGMLMWQSDVMMIEFLSSLRRNMAELRSLDAADCPECSGPPPMFRLPPPPRPPFLKEGTFCSEAPLAELEDCGNIPLIDVSYHNIPSLQSTALIVTCAIVLLLTTTTVFVVFWNYMTFKLSLDRYKPHDLQHEPFLLSDIKEPSRPRFLARPCFNIFGLSRVWQCLPTCCQTLEGPAASLIHAPLKETNDSRRAFVNQQPHPHQYRHYAVQHTDTAAMRTVNLQSDLTANHERFHYNCRSVSNNPHINNPRENNSQIKSPGRPSANSEHVMMLLSVAAQLTNKKPRFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HPB0</accession>
    <name>A0A8J2HPB0_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Arginyl-tRNA--protein transferase 1</fullName>
            <shortName evidence="5">Arginyltransferase 1</shortName>
            <shortName evidence="5">R-transferase 1</shortName>
            <ecNumber evidence="5">2.3.2.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Arginine-tRNA--protein transferase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HICCMSTLAB_LOCUS13429</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in the post-translational conjugation of arginine to the N-terminal aspartate or glutamate of a protein. This arginylation is required for degradation of the protein via the ubiquitin pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>an N-terminal L-alpha-aminoacyl-[protein] + L-arginyl-tRNA(Arg) = an N-terminal L-arginyl-L-aminoacyl-[protein] + tRNA(Arg) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10208"/>
            <dbReference type="Rhea" id="RHEA-COMP:9658"/>
            <dbReference type="Rhea" id="RHEA-COMP:9673"/>
            <dbReference type="Rhea" id="RHEA-COMP:10636"/>
            <dbReference type="Rhea" id="RHEA-COMP:10638"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78513"/>
            <dbReference type="ChEBI" id="CHEBI:78597"/>
            <dbReference type="ChEBI" id="CHEBI:83562"/>
            <dbReference type="EC" id="2.3.2.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the R-transferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.8" evidence="5"/>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5108793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HPB0"/>
    <dbReference type="OrthoDB" id="74183at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004057">
        <property type="term" value="F:arginyl-tRNA--protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017137">
        <property type="entry name" value="Arg-tRNA-P_Trfase_1_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030700">
        <property type="entry name" value="N-end_Aminoacyl_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007472">
        <property type="entry name" value="N-end_Aminoacyl_Trfase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007471">
        <property type="entry name" value="N-end_Aminoacyl_Trfase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21367">
        <property type="entry name" value="ARGININE-TRNA-PROTEIN TRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21367:SF1">
        <property type="entry name" value="ARGINYL-TRNA--PROTEIN TRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04377">
        <property type="entry name" value="ATE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04376">
        <property type="entry name" value="ATE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037207">
        <property type="entry name" value="ATE1_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="N-end aminoacyl transferase N-terminal" evidence="7">
        <location>
            <begin position="20"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="N-end rule aminoacyl transferase C-terminal" evidence="8">
        <location>
            <begin position="308"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="209"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR037207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAG5108793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="541" mass="63084" checksum="56D2E9B5759B1EE4" modified="2022-05-25" version="1">MAVNMFSVVDYYFTDVSRKYSCGYCKKRNSYKRHGMWAHSLTVQNYQSLIDRGWRRSGCYCYKPLNDETCCPMYTIKCEALNFIVTKSQKKIIKRVTKFLKEGKKDEDYNEKRSKRTKIHHNNPNDIDICNIMEPDYAEYTTRNKLDILEGEKMSVDVDCGTKRDSCTQSSDHNDHVNSHQQVNNEIDNTQWQPVTMVQDTLESVNSLANSSCSKSDKVNTKEPAASNSDSDLPRKAKLIRIERARSRLLAKGKTLEEIESYYKKKKDKNKTKTIDELLNNISDGVNELQVKLVRVSSEEFMDTLDQSVELFKKYQIAVHNDEEDECDKQSFLNFLGKTPLKHWKPESGPPLGYGSFHQQYWLNNTLMAVGVIDILPSCVSSVYFFYDPEYSFLSLGTYSSLMEVRLVRELNKTAPDLKYYYMGYYIHTIPKMRYKAKMRPSKLLCPETYSWFDIEKCIPKLNETKYSRLNDDLDALDEDGVINNDALMQVRVYYRGKMTYRNVQGIRRMFGDKKDDSNEVKEYAELVGKKCAHNMYLVRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HQ24</accession>
    <name>A0A8J2HQ24_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Similar to ift43b: Intraflagellar transport protein 43 homolog B (Salmo salar)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HICCMSTLAB_LOCUS13545</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IFT43 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5108909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HQ24"/>
    <dbReference type="OrthoDB" id="206950at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030991">
        <property type="term" value="C:intraciliary transport particle A"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035721">
        <property type="term" value="P:intraciliary retrograde transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029302">
        <property type="entry name" value="IFT43"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33724">
        <property type="entry name" value="INTRAFLAGELLAR TRANSPORT PROTEIN 43 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33724:SF1">
        <property type="entry name" value="INTRAFLAGELLAR TRANSPORT PROTEIN 43 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15305">
        <property type="entry name" value="IFT43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0970">Cilium biogenesis/degradation</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="28"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="82"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG5108909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="193" mass="21904" checksum="8286E18B743EA23F" modified="2022-05-25" version="1">MDWSNDHETNTKKQFIPRLGRRAGHNAIPEEPKFDKDTDSPVLAIPSATSVRTAPVAPPRTRKTGWSDESKSNKSKPVNIFDQEKLHRDNNNESDDIPVIPDIEEIQDESISNISNAPSVGINRVTAYKELDSDLLKNATFALLDNVNLSILTEKLYPEKLIKETDDVWNWEYLFAQVSSELNNEEQKIIMEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HQ81</accession>
    <name>A0A8J2HQ81_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS13213</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5108390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HQ81"/>
    <dbReference type="OrthoDB" id="7684885at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052088">
        <property type="entry name" value="E3_ubiquitin-ligase_SINA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10315">
        <property type="entry name" value="E3 UBIQUITIN PROTEIN LIGASE SIAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10315:SF83">
        <property type="entry name" value="RING-TYPE E3 UBIQUITIN TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="512"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="512"/>
            <end position="524"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5108390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="532" mass="61107" checksum="1AC3BBFAC1F4017F" modified="2022-05-25" version="1">MDFVKKKFLNWHSGIEKKIPCHFCSVKLSDEIYSCDFGHDVCQACKTDSCIACKKSSSFFRNHIAEFLVSQLNSLKSDVELLDDSVIAGTKSECKNQISQTKIECKNQISQTKIESKSKFSQTQNEQDNKINLAAKNVDESIENKSLTVEKSEDEPKNKNDNPSNFFGIYQCWIGRDCYLKGNQASILAHIKNQHPQEFTSQPFKGWPHVVAWDLNYNGANTREDRAFEIQGVGLFVLHIFVTHEQHLKAHVLMFDGGRTAAQYRYEVEIKCDDNKKSFSAAVDSSRLPRKALHDRSKGLFINENSMLQSTIKMKMKYRCTVQIMKINDTNEKKILDNFESPEVETKVRDHKNPKTLNKKQFKPMRKNANQFKDKSKPGLLDLRNVKIADCSSLSETTVPPVHLRKNNPFSVPGNSQLYPNLQKEFNYQQMPPQNPHMANNNFNMNMQQPMNVQPGPFYPQPPVSFNEHYQRNAPPPAPPSAPHIDMESNFHLPNKPGNFTAANLERQKLIQRQIEEQEKDRSRLTKNNIQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HQC2</accession>
    <name>A0A8J2HQC2_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">E3 ubiquitin-protein ligase Topors</fullName>
            <ecNumber evidence="2">2.3.2.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">RING-type E3 ubiquitin transferase Topors</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">SUMO1-protein E3 ligase Topors</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Topoisomerase I-binding RING finger protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">Topoisomerase I-binding arginine/serine-rich protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">HICCMSTLAB_LOCUS13774</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="2"/>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5109138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HQC2"/>
    <dbReference type="OrthoDB" id="365379at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006513">
        <property type="term" value="P:protein monoubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16574">
        <property type="entry name" value="RING-HC_Topors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000136">
        <property type="entry name" value="E3 ubiquitin-protein ligase Topors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058745">
        <property type="entry name" value="PWI_Topors"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018957">
        <property type="entry name" value="Znf_C3HC4_RING-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058746">
        <property type="entry name" value="Znf_RING-type_Topors"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46077">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE TOPORS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46077:SF1">
        <property type="entry name" value="TOP1 BINDING ARGININE_SERINE RICH PROTEIN, E3 UBIQUITIN LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26084">
        <property type="entry name" value="PWI_Topors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00097">
        <property type="entry name" value="zf-C3HC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 15" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="17">
        <location>
            <begin position="42"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="157"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="411"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="12"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="16">
        <location>
            <begin position="165"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="16">
        <location>
            <begin position="475"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="556"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="16">
        <location>
            <begin position="585"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="596"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="16">
        <location>
            <begin position="641"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="16">
        <location>
            <begin position="666"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="697"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="16">
        <location>
            <begin position="721"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="755"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="16">
        <location>
            <begin position="777"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="810"/>
            <end position="820"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00071236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00076856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00076940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00079040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00079184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="CAG5109138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="820" mass="93014" checksum="43256292DCE78E2F" modified="2022-05-25" version="1">MENPINQEDPETNTKEPVKAEEPAASNSGERSDGATSPPPNCSICLGKLINTSFTDSCLHQFCFTCLLQWSRIKTECPLCKQTFKSIIHNVRSEEDYDQYHVPRETHISQTHITTQALALSSALSNASISAYQRFAYRTTMTPSRRYGRLFAGLQANSSHHSRQEPPPVSISHPPPVSAQERRQRRNIYRSGEWSDPVSNVYSRFRQCSAEYYRRYPQEINRLIPWINRDLQTIFNPEQTPIAYVLDRITSLLQRYDMRSPEFRNEIRPLLQLETDHFIHELMNYASTDLTMAAYDDTVTYYNSFNPHGLSGLGYWHHVQSQTSSSTSSTISDDSDIRVVDHVDPSGSEVPSVGPHLISFPGPSTVSQVLQLQTPEARPFVLTITSSSSESECEIVGYVKPRCERTPEIIELIPRSPSPLSPINDQPSTSESSRRLSKNSKSKTSTRQLDRISPGSSESSSDSDSDFEESQTKKLANRRTSKHSTKVSKPSKSPRKSSGKKSDVSKKRSKHSYSSSDSPSPRESKCRRMSLNNSRKTTRAYISSSESDEDQPSSRNTEESSKTVDKDDKSKINCRVRVRKDLINGKKKHKRRTRRSSSSTSSTSSSSSESESESSNSSLDTTSTSLTTSSSYKVDKYKVDKSRKKKRSKSKRSSKQHKSTSDNLRRHNRSRSRSKSRSRSRSRSRSRSKSRSRSRSRSREELSDASEHYSVNERYRERKAAKIANKKLKNKHLYAMTDSQNDEEAYRSNSQCSEISDKHKASKSSEKKYKGESNSKAKSHKTKSHKKSSKKKRVKTRGETEKRPRRRITSSSSSSSFSST</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HR53</accession>
    <name>A0A8J2HR53_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS14084</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001750">
        <property type="protein sequence ID" value="CAG5110378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HR53"/>
    <dbReference type="OrthoDB" id="8191915at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579">
        <property type="entry name" value="F5/8 TYPE C DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579:SF1">
        <property type="entry name" value="F5_8 TYPE C DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5110378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="547" mass="62429" checksum="8B7CA8935B26DD8B" modified="2022-05-25" version="1" fragment="single">QDILKLVTISSGTNNANSSKHYWKKILDRYSQNVTTYYICEYCNNYLGSERDCPVQCDKCHKKVDRDANKGTFLHLPLADQLREIFEKTDAHQLYRINREKTNKYAIEDICDGKMYKKYILNETTISINFSVDGAPIFDSSNTSVYPVLCTIDELNPHDKRKYVLLSSVWFGVGKPKNMNSYLKPFVEEAKTLLKDGFSYTYQGQSFTKTVVTLMGICDSVARPLVRCSTQFNGEFGCGLCLHPGKSVEKGRGHARIYPLVNGNPFGDGLRTHEDTLLHAKASEKKDKKGIKGVSVLCDIPNYDIIKNLDADWMHCVGLGVCRQFAGLWFDSCNSSEKFYFGNKIAEFDEYITSFSPTSEISRTPRPLADRTHMKAHEWITFLLAYSLPVMKMCFPKQYVDHWALLVDGISILVKASIMKSEIKYADQYLRKFILGVELLYGEKYVSFNVHLLAHLAISVENWGPLYTHSAFIYEDFNQTIQASVNSPNGVEIQICDSFRLKFAIDRLSILCRDDLNYKQIEYLDMLMNRKSKPNSKTMICNCGVLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HRE6</accession>
    <name>A0A8J2HRE6_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Small ribosomal subunit protein mS31</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">28S ribosomal protein S31, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HICCMSTLAB_LOCUS13001</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrion-specific ribosomal protein mS31 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5107965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HRE6"/>
    <dbReference type="OrthoDB" id="5989925at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026299">
        <property type="entry name" value="MRP-S31"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13231">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOMAL PROTEIN S31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13231:SF3">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN MS31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15433">
        <property type="entry name" value="MRP-S31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="36"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="36"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00035363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAG5107965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="372" mass="42700" checksum="B3CD6ED07DE51A59" modified="2022-05-25" version="1">MNNLLVIQFIYRHAICRSKINHQQLCMAQRLMSSKDSSLSSSSSSSDSSNSDADPSKIKKIKKVKKLEIVERSETEKKETVDLLNSLLTNMTSVKIEDKTIRAVPKKERKPKPPKEPELEEKIINAAKDVAAVLGGDPEKTEAELLNKVFSAGKPTVSLENKEDSKPVQPSKLTLEELFSKMQIERKPKVLREMMPLSRSEKIQELIKKSEKTQVNLFSGKRLNIFDPVKAPEDSQMLSTWSSLEKKEIKTMMINPPENIFEEMIQWTDKGLLWQFPINNEFGLEEEEKVHFSEHIFLERYLQGWCPKTGPVRHFMDLVCIGLSKNPYMTVSEKEEHIMWLKEWFADKQDLLKETGAIDKDIVPNTSKQVPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HRK0</accession>
    <name>A0A8J2HRK0_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Similar to Fam13a: Protein FAM13A (Mus musculus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HICCMSTLAB_LOCUS13352</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAM13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5108668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HRK0"/>
    <dbReference type="OrthoDB" id="185175at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039102">
        <property type="entry name" value="FAM13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059029">
        <property type="entry name" value="FAM13A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15904">
        <property type="entry name" value="FAM13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15904:SF17">
        <property type="entry name" value="RHO-GAP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26116">
        <property type="entry name" value="FAM13A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rho-GAP" evidence="4">
        <location>
            <begin position="184"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="107"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="381"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="484"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="681"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="812"/>
            <end position="873"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="603"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="706"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="384"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="491"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="503"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="549"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="685"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="822"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="948"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAG5108668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="948" mass="107167" checksum="0D86A9B37C08F442" modified="2022-05-25" version="1" fragment="single">EAVSVPPRHSARQEGARTLIGAVGGSLDAYVTPRVDALLEATIGRYPPPRKQNNYTRKLGSRLLFKPRASIVLGPKAICRGNTALRLNNLYFNLWRAARECICGSGSRGRRTGMRRPQQESLQEDHHHHRHHHHPLCQGTLPSCSIEPRRNEKEESRLARVKRALTGSLLGRAGNGNCNRVFGARLELVESYLDTGVPYVVHRLCNYIEKHGFQHATLFRLSGGSPRLTERLRATFERKGDADLESAACPSTAATLLRQYLKELPQPLVPSSLVSRLLHVHSQEYEHHREEWVERTQQLLRCLPPSHYRLLGYLVHHLSNYEARHGRSSGVCGVFAPVVLPHVPPATTLLRDIITEASNARDSSAYPSVIPNDCEVCCNKPKDQQNNSTSNSEEQILESPPNGIESIRRVSSHEDFNSDKHLHIIYPDQDMGHGVRCTGLPLHERTNVSPVSTKPSPSPAPCDILLSADQLECDVERVRSTERFSRSITPRGRRVTRRKKTHKGLEIDLNSSKENENENEEQESNLYINIPDSNRRNQGTGQSFLEMLSSGPSRSPSPARPQEGDINNVEAMLSPRNSLLLPRRFYTENDVPPSVPGPAELGLKTLTKHINGLKKKIKKYEDEFEENFGYRPSHSDKMSNRDIKRLCSELNKLRKEHKMLKEDPIGMLRAAANRNKALDNATQVNNNNNNNNNNNNNNNNPEKSRATLMEEMLKDLERKLAEKRLKHARAENLEEMNYEQLLEEKTAVQKALLHIEDAFGRPVSKEDRAVVRVLYDRYRALKRLLIRAGITKNKDSISELATILEHEAMDFTSSSLPGNAGDGDRRASEPDMSHRGILDCIDAPEPLPTDSDSQHSSSEGSRNGPAESLHALPQEDLLAQQRVMREEKKCLRRALKELEAQFEARAGRKMQREDRGPHVTTVYESYKQTKAKLRLIDALWASFIWKRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HS36</accession>
    <name>A0A8J2HS36_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS13426</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5108790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HS36"/>
    <dbReference type="OrthoDB" id="7698113at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34239">
        <property type="entry name" value="APPLE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34239:SF2">
        <property type="entry name" value="TRANSPOSABLE ELEMENT P TRANSPOSASE_THAP9 CONSERVED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="DNA breaking-rejoining enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="350"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5108790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="502" mass="56456" checksum="A583F218DA85AC25" modified="2022-05-25" version="1">MGKSRKRSRSPRRSHSTSRDRSRSPKISKRDLQQQITAMAKSIAELIEVQKAANKAPNVEIQALKDPVDSANESSEKSVANESSDKVSEMKKPNDGDIEDGEVIIEDDYPELDDELLDVLGEEVTDSGCQVKVNEKLKKWWKGWMEKGFSEEVRKELLKKYPRDGEFVTEAPKVNLEVQRHLTEIAKKRDEHFKQTQSCVGSALSSLSTAVSMLTEVSTEPVNQTLLLQHLWDTGKILSDIFHQQSEARKSFITPTLDKDLKPTLDASVSDEWLYGQKLTEQVKEAKAIVKAASTLKATDKPIAKKPARKRERPTCEIQAGGLPLLEEIHERELSTPSSGNIIETSAENQYGQGSNVEEEVDTRGNEDSSKLRLKELSEILTTLLILITAHRMQTLALINIKDITRSSTGLSIKIPDLIKTSRPGKEQPILTVPFFKKREKLCVASIMLKYLERTENLRSNSDKLFISTIKPHKPASAQTISHWIKNGMYSPLAWFADMIVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HSK4</accession>
    <name>A0A8J2HSK4_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Apolipoprotein D</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HICCMSTLAB_LOCUS13730</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the calycin superfamily. Lipocalin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5109094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HSK4"/>
    <dbReference type="OrthoDB" id="565904at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007420">
        <property type="term" value="P:brain development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006869">
        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000302">
        <property type="term" value="P:response to reactive oxygen species"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042246">
        <property type="term" value="P:tissue regeneration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002969">
        <property type="entry name" value="ApolipopD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012674">
        <property type="entry name" value="Calycin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022271">
        <property type="entry name" value="Lipocalin_ApoD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000566">
        <property type="entry name" value="Lipocln_cytosolic_FA-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10612">
        <property type="entry name" value="APOLIPOPROTEIN D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10612:SF34">
        <property type="entry name" value="APOLIPOPROTEIN D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00061">
        <property type="entry name" value="Lipocalin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036893">
        <property type="entry name" value="Lipocalin_ApoD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01219">
        <property type="entry name" value="APOLIPOPROTD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50814">
        <property type="entry name" value="Lipocalins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0873">Pyrrolidone carboxylic acid</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035350923" description="Apolipoprotein D" evidence="4">
        <location>
            <begin position="18"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="domain" description="Lipocalin/cytosolic fatty-acid binding" evidence="5">
        <location>
            <begin position="40"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00019890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR036893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAG5109094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="184" mass="20961" checksum="C2024D5B1EDFEBA6" modified="2022-05-25" version="1">MMFGLTIICCVTAAAYGQFFNLGRCPEPHTPFVLDFDRFAGKYYEIERSFNNWDEVGGKCPTSYYIQIPDNELLVIHSDISEITNMQSGLIGKATVNGAKLSIHYHSPIMGDKTRDVWVIDTDHDTFAILWACTNYGFIHVTYGWTLVKKSYINRDFSAQIQAAFKRAKIPLMSMRKVDHTNCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HT89</accession>
    <name>A0A8J2HT89_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Similar to pum: Maternal protein pumilio (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HICCMSTLAB_LOCUS12951</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5107853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HT89"/>
    <dbReference type="OrthoDB" id="668540at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003730">
        <property type="term" value="F:mRNA 3'-UTR binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010608">
        <property type="term" value="P:post-transcriptional regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07920">
        <property type="entry name" value="Pumilio"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000004">
        <property type="entry name" value="Pumilio homolog 1 isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033133">
        <property type="entry name" value="PUM-HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033712">
        <property type="entry name" value="Pumilio_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001313">
        <property type="entry name" value="Pumilio_RNA-bd_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12537:SF12">
        <property type="entry name" value="MATERNAL PROTEIN PUMILIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12537">
        <property type="entry name" value="RNA BINDING PROTEIN PUMILIO-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00806">
        <property type="entry name" value="PUF"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00025">
        <property type="entry name" value="Pumilio"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50302">
        <property type="entry name" value="PUM"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50303">
        <property type="entry name" value="PUM_HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="PUM-HD" evidence="7">
        <location>
            <begin position="323"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="5">
        <location>
            <begin position="343"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="5">
        <location>
            <begin position="379"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="5">
        <location>
            <begin position="415"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="5">
        <location>
            <begin position="451"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="5">
        <location>
            <begin position="487"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="5">
        <location>
            <begin position="523"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="5">
        <location>
            <begin position="559"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="5">
        <location>
            <begin position="598"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="105"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="198"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="670"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="111"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="672"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="697"/>
            <end position="706"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG5107853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="706" mass="74822" checksum="3143138444F45819" modified="2022-05-25" version="1">MQRELNLVPQYYGVGPWVYPAGLLPQAPPQAAAPPPPRRPLTPSSAAAAAAAAQDSANNLAQTVQGQYQVIPTYYDQNGSLVMAGVRGLGSAATPMRLVSPAPVLVNRAPSQPPGPPAPPPPSLYSQPTSTSHNNATPGECLGLAAGSAAVIAQAQAVAVQQAQQQGTGLAAGLAALGYGGSPLGALGSPAQLQSTGLGLGASSTGRRDSFDRNTSAFSPSLEYSRGKWPQSYGALGTVTASPSPLGLSLTPPPTIGGSLGGLVGGANRVSAAPGAEAKFRTSAVPTLTANGVFGSSSSLFPNLVGKPGRSAASGVGDKGAGGRSRLLEDFRNNRFPSLQLRDLANHIVEFSQDQHGSRFIQQKLERASAAEKQLVFQEILASAYSLMTDVFGNYVIQKFFEFGTPEQKSTLAQKVRGHVLPLALQMYGCRVIQKALESIGPEQQQEIVRELDGHVLKCVKDQNGNHVVQKCIECVEPRALQFVIGAFAGQVYSLSTHPYGCRVIQRILEHCTPEQTQGILQELHSATDQLIQDQYGNYVIQHVLEHGKIEDKAQLISSVRGKVLALSQHKFASNVVEKCVTHATRQERAVLIEEVCGFNDNALNVMMKDQYANYVVQKMIDVAEPAQRKVLMHKIRPHLSSLRKYTYGKHIIVKLEKFFMKTASAIGVSSPAGTTNNTSDLGPIGPPTSAAGSVPTQTQQSTQVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MBM0</accession>
    <name>A0A8J2MBM0_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Olfactory receptor 76</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS3427</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5081980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MBM0"/>
    <dbReference type="OrthoDB" id="6617147at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0675">Receptor</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5081980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="165" mass="19561" checksum="C2882224AB91FA22" modified="2022-05-25" version="1">MVLTITDMYKSVNNTEKFINNITESLRIVIVYVRMFMLRFNISSLGEIYSQIFKDYNVSDFENSQEIEVFMQFINKGIFLVREFASFMTAEFFINDNNRTIFIIPYKLYFFHEITSLTRYYLTFLCIMPSIWAFGFGNVSVDSTLISLLFYIIGKMTVLMRIDTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MC24</accession>
    <name>A0A8J2MC24_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS3667</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5082848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MC24"/>
    <dbReference type="OrthoDB" id="7447178at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="219"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="221"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="232"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5082848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="353" mass="41665" checksum="DBE5AA6155911692" modified="2022-05-25" version="1">MSLIETLLNRFDTVYFNAIINALKEDKMEQCKVLLRAIFMGQLAAEELDDTREKYKKMARDVWKNMKERERTLNILRSRVENLWADIRELVRVEVLSFEEQARQKKHLLKKLEDNLEVRESLINKRNCATLILADLNNSLISTSGEYDKQVFYCVFYFHDYKYKADKKEILEEIKIAKKREDDFIKSEKSREELLINIKCALQNILAMMVFIRPGLGGVKKSPREKKRDRRKTSESSDGKASRKSKGQFIEQVEYHLEKFDPDVLTLLNQVTKKANMLFGLSNFEMTLEEEEKAKNLYQSYVAEKRSKIYYENDVVEQKELTVEHEIIDLSVISRADIKNQSKNLIEMCTRLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MCT1</accession>
    <name>A0A8J2MCT1_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Similar to dnajc22: DnaJ homolog subfamily C member 22 (Xenopus tropicalis)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HICCMSTLAB_LOCUS3353</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5081686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MCT1"/>
    <dbReference type="OrthoDB" id="10262359at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007829">
        <property type="entry name" value="TM2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44733">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44733:SF1">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05154">
        <property type="entry name" value="TM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="30"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="55"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="109"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="141"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="167"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="223"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="TM2" evidence="6">
        <location>
            <begin position="27"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF05154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAG5081686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="281" mass="32484" checksum="D5064365920426DA" modified="2022-05-25" version="1" fragment="single">MELTNGTKETSKKVHSNGTIVPERKLKSKFWAYFWWVFGGIFGAHHLYLGRDAHAFIWLTTLGGYFGIGWLRDLLRISTYVDDVNNHPHFVESFKLAVRHNKKPTFSTVRFIGALIVGYFWGLLLWSAIPQDEIHGYNLRPLMIFVPLAVALGVWVIGNIGREQGSLWLTLACSYLMYPTLYYIGDDSTWLSLMVVVDALVFDTFSKQWRLKPREKKSVGKRVITFSLALALYLALWTSYFYFNAVTTLWATWEQVKNQGFWATWQQLVDMSDLRGEMNAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MF69</accession>
    <name>A0A8J2MF69_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Similar to atk: Protein artichoke (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HICCMSTLAB_LOCUS4867</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5088485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MF69"/>
    <dbReference type="OrthoDB" id="2013775at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:001164">
        <property type="entry name" value="GH01279p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050328">
        <property type="entry name" value="Dev_Immune_Receptor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026906">
        <property type="entry name" value="LRR_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24373">
        <property type="entry name" value="SLIT RELATED LEUCINE-RICH REPEAT NEURONAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24373:SF275">
        <property type="entry name" value="TIR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13306">
        <property type="entry name" value="LRR_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00364">
        <property type="entry name" value="LRR_BAC"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035179562" evidence="4">
        <location>
            <begin position="23"/>
            <end position="622"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAG5088485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="622" mass="70469" checksum="139084CF13C68866" modified="2022-05-25" version="1">MKRQLEMSRIILLLGIALRANTQAPVLRRQHYLLEIDNGILNNVKPYPQALGKDVDLSDLGLRSVQKNAFDQLVNIKSLNLDNNSLQELPEFVFANLTTLQALSLAKNNFNTFQNNFVGLNNLKTLNISYNPLKHLRKSFFFGLTKSTEIITEGNEFWSISTELFENPFLREMEPNHQLEFDESPDKNPTLRNNDDNLILDDNLKVKICKTAQGVVNTVEELQTNETLSSECKQAGIIYERRTLVLKNLGLKAVQKGWYKLNKYPFNSIDLSMNNIEEITPELLNDLPENLAFVNLAGNKIKQLRRNIIENNYLKVLNLKDNLIMEIEGGALEKTQLSGFFIIGNCLKSLSFASTLPITLTEMIASQNDIEEIPENSMANLKNLVYLNLAHNNITELKSNTLRGLTSLQVLILTDNKLKTIEEGAFKDMINLRTLYLYRNAISDLKSGFVRGLENLKDLNLAWNNIKKITNDTFIELPDTLRDLHLDFNEIESLEVGSFVDVPKFTLSLDGNKISAIPRGAFNLPYLHELHLKNNSLQSIDGDAFEGLWRLRRLSLNANNITSIKKGAAKNMGRIHLLDLSKNPIEKLENGALFGLPKSRGCFVYLSDTFLKIIQGGIFDDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MFI0</accession>
    <name>A0A8J2MFI0_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Mitochondrial (Mus musculus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HICCMSTLAB_LOCUS5064</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bS18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5089007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MFI0"/>
    <dbReference type="OrthoDB" id="10066799at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070181">
        <property type="term" value="F:small ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.640.10">
        <property type="entry name" value="Ribosomal protein S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001648">
        <property type="entry name" value="Ribosomal_bS18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036870">
        <property type="entry name" value="Ribosomal_bS18_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13479">
        <property type="entry name" value="30S RIBOSOMAL PROTEIN S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13479:SF40">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN BS18M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01084">
        <property type="entry name" value="Ribosomal_S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46911">
        <property type="entry name" value="Ribosomal protein S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG5089007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="134" mass="15625" checksum="1F8229F098D8C717" modified="2022-05-25" version="1">MALSKNLFGISKLALTLSRRLVHNIVDTTKPKEGIFPNGPLDEDLEKKQCVLCRLNVTPDWKNVRLLSQFQSAYTGRIYGRHITGLCKHKQELVEREILKAQNSGFMPFYMKEPNYLHDPMLFDPDHPFRPHKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MFX4</accession>
    <name>A0A8J2MFX4_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein eL31</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">60S ribosomal protein L31</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HICCMSTLAB_LOCUS2729</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL31 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001117">
        <property type="protein sequence ID" value="CAG5078406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MFX4"/>
    <dbReference type="OrthoDB" id="9739313at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00463">
        <property type="entry name" value="Ribosomal_L31e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.440.10:FF:000001">
        <property type="entry name" value="60S ribosomal protein L31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000054">
        <property type="entry name" value="Ribosomal_eL31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020052">
        <property type="entry name" value="Ribosomal_eL31_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023621">
        <property type="entry name" value="Ribosomal_eL31_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10956">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10956:SF0">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01198">
        <property type="entry name" value="Ribosomal_L31e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01380">
        <property type="entry name" value="Ribosomal_L31e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54575">
        <property type="entry name" value="Ribosomal protein L31e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01144">
        <property type="entry name" value="RIBOSOMAL_L31E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAG5078406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="131" mass="15128" checksum="A4A5AE50966F7F35" modified="2022-05-25" version="1">MPKINMTAMAKTSDKKGKSAINEVVTREYSINLHRRLHGVGFKKRAPRAIKEIRKFAEKQMGTPDVRIDTRLNKQLWSKGIRNVPFRVRVRLSRRRNDDEDSANKLYTLVTYIPVATFKGLQTENVDASQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MGS9</accession>
    <name>A0A8J2MGS9_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NMDA 2A (Xenopus laevis)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HICCMSTLAB_LOCUS5714</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5090673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MGS9"/>
    <dbReference type="OrthoDB" id="5984008at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015276">
        <property type="term" value="F:ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001320">
        <property type="entry name" value="Iontro_rcpt_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00060">
        <property type="entry name" value="Lig_chan"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="domain" description="Ionotropic glutamate receptor C-terminal" evidence="3">
        <location>
            <begin position="19"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG5090673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="88" mass="10095" checksum="8FE6A8292A066168" modified="2022-05-25" version="1" fragment="single">LSLLFCKRFFFFSEPFDAASWMLVGIVSIHAATFMIFLFERLSPTEFDPKKVILPKPGFSITRSYWLVWAVLFQASVQVDSPQGNTAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MGZ0</accession>
    <name>A0A8J2MGZ0_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS3002</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001117">
        <property type="protein sequence ID" value="CAG5079402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MGZ0"/>
    <dbReference type="OrthoDB" id="7700334at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5079402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="137" mass="15985" checksum="F7F359993F4BFBDA" modified="2022-05-25" version="1">MKLLLQFLRRFMDPLMLKPEIFYDNVHNIIFEAVSNQLNLFEVDVGPDCREYLLLQQKSGVPESIIKQVRNDCLKFLVTASIEIRRRLPIDDPFLSDLTVFAKETTLFDPDRNSSFSKVENTCHALKVPRGRLIQEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MH45</accession>
    <name>A0A8J2MH45_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Similar to thoc6: THO complex subunit 6 homolog (Danio rerio)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HICCMSTLAB_LOCUS5320</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat THOC6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5089659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MH45"/>
    <dbReference type="OrthoDB" id="273067at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000347">
        <property type="term" value="C:THO complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000346">
        <property type="term" value="C:transcription export complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042626">
        <property type="entry name" value="THOC6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44411">
        <property type="entry name" value="THO COMPLEX SUBUNIT 6 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44411:SF1">
        <property type="entry name" value="THO COMPLEX SUBUNIT 6 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 4" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="157"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAG5089659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="330" mass="36792" checksum="4BA3F9EBB549D33D" modified="2022-05-25" version="1">MPENLNNKLFYNTVLCQTFSPSGKHLVAGNIYGDISVFDLSKSLSPVSDENDLPGPSYKFTAYPGQHVQAMLSTDDFLVTGTAGEISGWDWNVVTSSKASKIKVSWTVQIPADKDSSEKSDVNYIVYSNDKHYLYAGCGDKKIYVINLDNGKIVKTLEGHENFIHCLALMNNQLASGSEDGSVRLWDLRTYENTSILKPHLVDKVARPKLGKWIGAVDFTEDWLLCGGGPNLSLWHLRTMEPATVFDLPDQGIHEAKIFEERVIAGGTMPHVYHLNYQGEIFAEVPTSSHTVYSIVYQEKPHKVLSIAGSSNKVDICTNFNYRELVFKFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MIH3</accession>
    <name>A0A8J2MIH3_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Eukaryotic translation initiation factor 3 subunit L</fullName>
            <shortName evidence="4">eIF3l</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HICCMSTLAB_LOCUS6880</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the eIF-3 subunit L family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5093494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MIH3"/>
    <dbReference type="OrthoDB" id="15082at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005852">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03011">
        <property type="entry name" value="eIF3l"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019382">
        <property type="entry name" value="eIF3l"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13242">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13242:SF0">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10255">
        <property type="entry name" value="Paf67"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4 6" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3 4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="5">
        <location>
            <begin position="297"/>
            <end position="514"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAG5093494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="539" mass="63832" checksum="F23234E8A4FD3C0D" modified="2022-05-25" version="1">MYDEYSDQYDTFEDYGPPDVHTDSYERFRQVPEVVRKFLIYFRNCINEGMIFEIQNLYENTFPKISEQLFEKQSWPDESEIAHIVENDTVFLILYKELYYRHIYARMQGPTLEQRFGSFYNYCDLFNYILNPDEPVQLELPDQWLWELIDEFVYQFQSFSHYRANLTNKTPEEIENLSNHNKVWDILCILNVLHYLVDKSKIKSQLEIYASGGDPDSVAGPFGKHSLYKMLGYFALIGLLRVHSLLGDYYQAIKVLENVEIYKKSAYSHVPGCQISTAYYVGFAYMMMRRYADAIRTFSGILLYIQRTKQLFTTRSYQNDQINKQTEQMYHLLAICLVLHPQCIDEGLQQALRERNYHEKMYKMQYGDIVEFESCFLFACPKFFSSTPPSPDSTREDYTKDAIKHQTQVFMDEVIQQKMLPTIRSYLKLYTTLPLSKLATFMYRSNSSSTDENWDLDKEVAALTIHLLCFKHKMKNIVWTKGASGLDGKFQSGSELDFYIDHDMIHIADTKVAHRYGDFFIRKILKFEELNRKLHHIKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MLG8</accession>
    <name>A0A8J2MLG8_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS6349</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5092745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MLG8"/>
    <dbReference type="OrthoDB" id="7669970at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5092745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="64" mass="7530" checksum="EAA67FB37B5FFB61" modified="2022-05-25" version="1">MNAVKNYVENPKDWVPNKYTRISSTHFVNNEKSEHPLHPSYVPSIFPGRENIKRNKLFSNNCKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MLU8</accession>
    <name>A0A8J2MLU8_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to EMC8-9: ER membrane protein complex subunit 8/9 homolog (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS6822</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the EMC8/EMC9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5093432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MLU8"/>
    <dbReference type="OrthoDB" id="194468at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072546">
        <property type="term" value="C:EMC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08060">
        <property type="entry name" value="MPN_UPF0172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005366">
        <property type="entry name" value="EMC8/9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12941">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12941:SF10">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 8_9 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03665">
        <property type="entry name" value="UPF0172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MPN" evidence="2">
        <location>
            <begin position="4"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5093432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="211" mass="23877" checksum="D294DEF177749E8F" modified="2022-05-25" version="1">MSKVTFSPRACSKIILHATKYPHCAINGLLLAKQKNKNDMKLTDIYIQDAIPLFHQCLHVSPMAEIALTLVDQFAEQNEMVIAGYYLANELVNDMSTDKPAHKIADKIAENFNNALLVVVDNKEMTCNMNSIPLKISQHSDGKWKVKDKADVSYEGGDAAVETISTLMKENKYNILFDFDNHLDNITLDWRNNNLNKIINKTMSYNNEIPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MM80</accession>
    <name>A0A8J2MM80_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to nrf-6: Nose resistant to fluoxetine protein 6 (Caenorhabditis elegans)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS7804</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5095629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MM80"/>
    <dbReference type="OrthoDB" id="207378at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002656">
        <property type="entry name" value="Acyl_transf_3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006621">
        <property type="entry name" value="Nose-resist-to-fluoxetine_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052728">
        <property type="entry name" value="O2_lipid_transport_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11161:SF72">
        <property type="entry name" value="FI21449P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11161">
        <property type="entry name" value="O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01757">
        <property type="entry name" value="Acyl_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20146">
        <property type="entry name" value="NRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00703">
        <property type="entry name" value="NRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="317"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="370"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="431"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="458"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="501"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="531"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="563"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="636"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="domain" description="Nose resistant-to-fluoxetine protein N-terminal" evidence="2">
        <location>
            <begin position="51"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5095629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="693" mass="79352" checksum="44E6D68901BBADC3" modified="2022-05-25" version="1">MDRARISTHLLRSPQIRVLDLHFEFDNSTPGDAIDLLIHSNTTLNAFLLTKLEHLDSFDGVSRVRRYCIILDSSGEPKSGFIYGNNFWLGSKSQCLDLENTKPLELDPVFLKSVSKYRNIDEEFPPFHLNYFIAHFYHNSTHQYQCRLRNEDLISLGLCLPASCSSDQLSRILEKMFEAKILAVGNLYSADYRLHSVRGITIILAIIGTFYDCIVHQKRLELIKSSKKIANNSDVKSTSVLQQNFLGQILLCFSVHTNTKQIFDTKESIKDVIPSLFGLRSLEMIYVCMLHTIIYAPDFLDNRVAMLRLTEGFVNQIFANGHISVDTFFCLSGFSISWAFFGKKVNVYSGAKSFRHFPWRKFFDLTLKRIIRMAPVYFMIIGITGMIFGWYNANSSFVIAENPYHNCNKYWWRNALFINNLFPWNELCMTWSWYVPCDIQFFIIGTFLLLLSEIHFYASAFLLMALLVISVIVNGLISYGYGYTATIEQMFLQPEILYSSPWMRIGPYLVGIIAGYVLRSLNGKLDLSTKILCLLWIVGSSCNISVLFGLYQRNFSPMSAAMYVAFGRIVWALGIAWIVIACHTNNAGFINKILSLKIWNPLCKLTYSAYLLNPLVTLSVAMTSESSMHLDNFRCFIYFLGLTAFTIFSAFIATILIETPCNLLFQLPNKLRKKRSVIIAARYDGKSFFKLVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MMT9</accession>
    <name>A0A8J2MMT9_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Similar to Rest: RE1-silencing transcription factor (Mus musculus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HICCMSTLAB_LOCUS7775</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the snail C2H2-type zinc-finger protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5095571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MMT9"/>
    <dbReference type="OrthoDB" id="8922241at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000448">
        <property type="entry name" value="RE1-silencing transcription factor A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000446">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050527">
        <property type="entry name" value="Snail/Krueppel_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24388:SF53">
        <property type="entry name" value="CHORION TRANSCRIPTION FACTOR CF2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24388">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13909">
        <property type="entry name" value="zf-H2C2_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="166"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="195"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="224"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="252"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAG5095571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="275" mass="32271" checksum="1D0407BD58AD5C94" modified="2022-05-25" version="1" fragment="single">LKIVKVMDKRELASSSILRMLEMNHDNIRFNEDKYQDKSHSVITLSREKIAEVGSMSEQKHDSMDNETDKAQGLNYLEKENFESEITIMDDSESYSGDNGNVDTDDYLIYQKSNIADYLVKQNEFISLSYYVEDFESIINEKIGAEELNAENYDSNQMFEENGSKYHCKKCDRTFDVFKLFEKHILYRHTGFKRHQCKECDYATNNLSHLKRHIKTHAEQHITHNCSHCNFTCESSRSLKKHVYTHNNLRPYKCPSCPYASATLNHLTRHKLIHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MNB7</accession>
    <name>A0A8J2MNB7_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Electron transfer flavoprotein subunit alpha</fullName>
            <shortName evidence="7">Alpha-ETF</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HICCMSTLAB_LOCUS7044</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="7">The electron transfer flavoprotein serves as a specific electron acceptor for several dehydrogenases, including five acyl-CoA dehydrogenases, glutaryl-CoA and sarcosine dehydrogenase. It transfers the electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase).</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7 8">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="7 8">Binds 1 FAD per dimer.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Heterodimer of an alpha and a beta subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the ETF alpha-subunit/FixB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5093718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MNB7"/>
    <dbReference type="OrthoDB" id="1715808at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045251">
        <property type="term" value="C:electron transfer flavoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033539">
        <property type="term" value="P:fatty acid beta-oxidation using acyl-CoA dehydrogenase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01715">
        <property type="entry name" value="ETF_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000041">
        <property type="entry name" value="Electron transfer flavoprotein alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1220:FF:000001">
        <property type="entry name" value="Electron transfer flavoprotein, alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014730">
        <property type="entry name" value="ETF_a/b_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001308">
        <property type="entry name" value="ETF_a/FixB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033947">
        <property type="entry name" value="ETF_alpha_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014731">
        <property type="entry name" value="ETF_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018206">
        <property type="entry name" value="ETF_asu_C_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43153">
        <property type="entry name" value="ELECTRON TRANSFER FLAVOPROTEIN ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43153:SF1">
        <property type="entry name" value="ELECTRON TRANSFER FLAVOPROTEIN SUBUNIT ALPHA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01012">
        <property type="entry name" value="ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00766">
        <property type="entry name" value="ETF_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000089">
        <property type="entry name" value="Electra_flavoP_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00893">
        <property type="entry name" value="ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00696">
        <property type="entry name" value="ETF_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0249">Electron transport</keyword>
    <keyword evidence="5 7 8" id="KW-0274">FAD</keyword>
    <keyword evidence="4 7" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Electron transfer flavoprotein alpha/beta-subunit N-terminal" evidence="9">
        <location>
            <begin position="23"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="225"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="250"/>
            <end position="251"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="264"/>
            <end position="268"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="281"/>
            <end position="288"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="302"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR000089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000089-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAG5093718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="332" mass="34731" checksum="C88ED7D666F1F402" modified="2022-05-25" version="1">MFANCLKSARHNKFGSLARFESTLVIAEHNNETLTPITQAVLSAAKKIGGDITVLVAGTKCGPAAAALCKANGISKVLVAESDAFKGFTPESMTPLILATHKQFNFSHIMAGGSAFGKALIPRVAAKLDVSPVSDVINIKSSDTFVRPIYAGNALQTVKVKDSIKVVTVRGTSFEALPLEGGNASTEPAPAGEYKSNLIEFIKQELSKSDRPELTSASVVVSGGRGLKSGDNFKLIYSLADKLNAAVGASRAAVDAGYVPNDMQVGQTGKIVAPDLYIAVGISGAIQHLAGMKDSKTIVAINKDPEAPIFQVADYGLVADLFKAVPELTDKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MNC3</accession>
    <name>A0A8J2MNC3_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Chitin-binding type-2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HICCMSTLAB_LOCUS7059</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5093733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MNC3"/>
    <dbReference type="OrthoDB" id="6020543at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.140.10">
        <property type="entry name" value="Chitin binding domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002557">
        <property type="entry name" value="Chitin-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036508">
        <property type="entry name" value="Chitin-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051940">
        <property type="entry name" value="Chitin_bind-dev_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23301">
        <property type="entry name" value="CHITIN BINDING PERITROPHIN-A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23301:SF110">
        <property type="entry name" value="LD43683P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01607">
        <property type="entry name" value="CBM_14"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00494">
        <property type="entry name" value="ChtBD2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57625">
        <property type="entry name" value="Invertebrate chitin-binding proteins"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50940">
        <property type="entry name" value="CHIT_BIND_II"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0147">Chitin-binding</keyword>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035269399" description="Chitin-binding type-2 domain-containing protein" evidence="7">
        <location>
            <begin position="29"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="8">
        <location>
            <begin position="32"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="8">
        <location>
            <begin position="214"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="8">
        <location>
            <begin position="478"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="8">
        <location>
            <begin position="681"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="90"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="271"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="532"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="741"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="100"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="134"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="157"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="208"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="271"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="297"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="325"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="372"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="414"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="428"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="446"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="534"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="544"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="583"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="617"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="638"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="741"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="751"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="788"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="811"/>
            <end position="821"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAG5093733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="827" mass="87990" checksum="072CBA67194421AE" modified="2022-05-25" version="1">MQYTFSSNICQDLFTIFFLCCLGDYATGQGNNFKCQEEGYQADPRECQVYYRCVSWGSSGPLTTFKFECGPGTVFSHSKGNICVHPRDSERSECSEMGNDVNSVYQPQHRPQYSSSRPTQHYPSSSTASRPQHRPQYPTSSSPSRPQYPSSSRPTRPHPPQYPSTPSRPRPQHPSTPTSRPQYIPPPTESPHANEINPEAGPRPGSNRPATGGQSQCQSEGFMAHPQDCKKFIRCVNDGFGSYSTFEFTCGEGTVWDSTIEGCNHAWAVKSSCGSSGASPGSSHSDGNLPEPGHPSQGPNSNQPGSDSSDPESGYPSQGKEPDQNQDPGTEQGSNGSEEPSTPDESNPNVPSQGQDSNYPDNDNPNEESPDQESNPSVPSGDSGYPGQNSPGQDPDNPNEPGEDSDYPDFRPSSPYPLYPPGPEPPSATTESLDASTVRQPLATKPPSSAASPAEPNLPESEGPQAETTNKPGAGSGSGDCNEEGFFPDPKDCHKFFRCVKADSAFTKYEFECGESTAWDPSIQTCNYEYAVSNCKNPGSSGQTTPSSAPTETSSKDEEPDSDKDQSSSPPSVESSTEEDKQSSPSSTDSSDTSSDETPTTSTTSASASSNPEDVETPSSTEESSPPDSNETPPEPSPEEKPTSTTKEPTESESKPTTENTPSTAASAGADKKPSGPGMSGSSCKDEGFFPNPSDCRKFFRCVKGDNGLIKYNFDCAPGTAWEQSLLTCNYIHLVASCGSETNQVSSPEADSNKDKDKDGDKEKDEGKPTEKPKDEGEGSSSSDSTTQGSNKPTDSSNGSNKPSQVSPSGDSDRSLAERSIKKAAST</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MPQ2</accession>
    <name>A0A8J2MPQ2_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Similar to SIX4: Homeobox protein SIX4 (Homo sapiens)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HICCMSTLAB_LOCUS9849</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 9 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5100776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MPQ2"/>
    <dbReference type="OrthoDB" id="3501850at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000085">
        <property type="entry name" value="SIX homeobox 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031701">
        <property type="entry name" value="SIX1_SD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10390">
        <property type="entry name" value="HOMEOBOX PROTEIN SIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10390:SF44">
        <property type="entry name" value="SIX HOMEOBOX 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16878">
        <property type="entry name" value="SIX1_SD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="5 9 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 9 10" id="KW-0371">Homeobox</keyword>
    <keyword evidence="8 9 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Homeobox" evidence="12">
        <location>
            <begin position="210"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="9">
        <location>
            <begin position="212"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="277"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="332"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="18"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="279"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="341"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAG5100776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="378" mass="41416" checksum="2BB34FFD50A11C5C" modified="2022-05-25" version="1" fragment="single">MSESSDQLSSPSSDCNSQMGHRSVGSSHTGYNNIMSGLSLSIHQHQGNGISGGSRYGQEQSNCTNSVDVSTSNINVGNLSVSSNSTNFTPEQISCMCEALSQSQDIEKLTRFLWSLPPGELLRGDESVLMARAAVAFHRCAFHELYSILESHPFSPRRHPELQQMWFKSHYSEAEKIRGRALGAVDKYRLRKKYPLPKTIWDGEETVYCFKERSRNALKECYTRNRYPTPDEKKSLAKKTGLTLTQVSNWFKNRRQRDRTPQARPDMLSLNCQSNNGNINGGNNSGNTVGGGHQPLQSLESGSPNLAMSPISTMGMSPVGMNPCSPMGLSPMGPHHHSYGSPVTPSSIHSAHPSNGGLSPMSDVKTLSYGRGAYDNGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MPS5</accession>
    <name>A0A8J2MPS5_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Endonuclease/exonuclease/phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS9683</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5100610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MPS5"/>
    <dbReference type="OrthoDB" id="7700971at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14529">
        <property type="entry name" value="Exo_endo_phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="1">
        <location>
            <begin position="136"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5100610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="294" mass="33007" checksum="CC3DFDA5CCDECDBA" modified="2022-05-25" version="1">MKQLMIWRHEDKSDMAKFMAEVFERISNETDRLSSRDVTAITFWNARGLPEPQVLLSLKEGTIIHISETWRTTGKTNLPSSLDSYNKVWSPAIKNKILGRPSGGLVTLIDKDLNYRILSSSHHWLATLVTINDVKIIMVSLYLSPSSSISTVLNDFKLTLDDLLLSTDFDLFIIGGDFNARLGLLNTVPLEAADGSHITLKRNSMDTKVTQRGIALNNFMEEHRFVLLNGRCHPDTSGKFTFFGAQGLSVVDLVWVNTASIDLITEFSVDQSAYRSDHYPIVVKVATKAHKPHM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MQF0</accession>
    <name>A0A8J2MQF0_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to fgf1: Fibroblast growth factor 1 (Xenopus laevis)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS10196</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the heparin-binding growth factors family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5101123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MQF0"/>
    <dbReference type="OrthoDB" id="5987799at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008083">
        <property type="term" value="F:growth factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00058">
        <property type="entry name" value="beta-trefoil_FGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002209">
        <property type="entry name" value="Fibroblast_GF_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008996">
        <property type="entry name" value="IL1/FGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056378">
        <property type="entry name" value="Let-756-like_FGF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11486">
        <property type="entry name" value="FIBROBLAST GROWTH FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00167">
        <property type="entry name" value="FGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00442">
        <property type="entry name" value="FGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50353">
        <property type="entry name" value="Cytokine"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="14"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5101123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="204" mass="23436" checksum="11207C45B3557C31" modified="2022-05-25" version="1">MSLRWIQENKEAPTCDEESSDIDDSATDDSYDTDEDEIDNENSLSQPRNKRNSTRHPTTTVTFENGIPVYKTNQEDNSSACIVWDPRNSIQNPAYRCRLIKLFCRTGYHLTVSPAGFVLIRIQNPETGHYLAFNKKGHLYGELKENKDNTEWEQWSIGSYEAFRSLKYSAEGWWIGVKKNGRPKSGPKTAWGQRAIQFTVIGYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MQK7</accession>
    <name>A0A8J2MQK7_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to ATG7: Ubiquitin-like modifier-activating enzyme ATG7 (Gallus gallus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS11390</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5103199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MQK7"/>
    <dbReference type="OrthoDB" id="338614at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000407">
        <property type="term" value="C:phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019778">
        <property type="term" value="F:Atg12 activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019779">
        <property type="term" value="F:Atg8 activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006995">
        <property type="term" value="P:cellular response to nitrogen starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032446">
        <property type="term" value="P:protein modification by small protein conjugation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.100">
        <property type="entry name" value="Ubiquitin-like modifier-activating enzyme ATG7 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.70">
        <property type="entry name" value="Ubiquitin-like modifier-activating enzyme ATG7 N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032197">
        <property type="entry name" value="Atg7_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042522">
        <property type="entry name" value="Atg7_N_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042523">
        <property type="entry name" value="Atg7_N_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953">
        <property type="entry name" value="UBIQUITIN-ACTIVATING ENZYME E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953:SF3">
        <property type="entry name" value="UBIQUITIN-LIKE MODIFIER-ACTIVATING ENZYME ATG7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16420">
        <property type="entry name" value="ATG7_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="Activating enzymes of the ubiquitin-like proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like modifier-activating enzyme Atg7 N-terminal" evidence="2">
        <location>
            <begin position="6"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="domain" description="THIF-type NAD/FAD binding fold" evidence="1">
        <location>
            <begin position="342"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16420"/>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5103199.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="630" mass="70615" checksum="E670A59654A9A3DA" modified="2022-05-25" version="1">MSLNMVKFTKLRTAIDPSFWAKLAELKLDKYKLEDKTEISIWSGYSLDKAYENRTSPMILDCTSFNENVETTSLNGSVVCTGILINTNTFESFRQTQPDKFIDSLGKHLKDAIIDGTALKEPWRLTLFLLLSYADLKKHRFHYWAAYPTLFNLPEIHYDGPRTKATEILSSSDFSKLQTDFNNLDSKFKSFFAILLSSDGLKIMTLFEGVTYVNSSLVKAKETSCVDQKLYFAFYDPCDTLEPGWPLRNLLCLLFYSCPDFTYSKTINILSLRGKNLESSIIFSIKTKGGEKILDRKEIIEGRLVGWEANVNGKMGPNIADLSESLDPNRMAARAVGLNLKLMKWRLVPDLDLEKVSKLRCLLLGAGTLGCSVARVLIGWGIKNITFVDSSTVSHSNTVRQTRWLPTLLCAVFDKMAINAALGFDSYTVQRHGTRRVTVATSPDLTQNCPSGEDLGCYFCNDVTQPGNASFISQADRTLDQQCTVSRPGLSSIAAGLAVELMIAVTQHSKGIGANAFMDDGRNQYRSSERESCEGLLGLIPHTLRGSLWNYEMRLTITHRFPSCTACSIPIINEYRKRGFDFILDACNQPNYLERIAGLEDLLKRPNLDELCYAIDSSDEDSENISLTKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MR76</accession>
    <name>A0A8J2MR76_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Similar to RAD54L2: Helicase ARIP4 (Homo sapiens)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HICCMSTLAB_LOCUS10935</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF2/RAD54 helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5102278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2020972at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.850">
        <property type="entry name" value="SWI2/SNF2 ATPases, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044574">
        <property type="entry name" value="ARIP4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45797:SF1">
        <property type="entry name" value="HELICASE ARIP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45797">
        <property type="entry name" value="RAD54-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 12" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="10">
        <location>
            <begin position="909"/>
            <end position="1013"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="11">
        <location>
            <begin position="1969"/>
            <end position="2130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
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    <feature type="region of interest" description="Disordered" evidence="9">
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            <begin position="626"/>
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            <begin position="821"/>
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            <begin position="1146"/>
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            <begin position="1593"/>
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            <begin position="1754"/>
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        <location>
            <begin position="2379"/>
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            <begin position="2442"/>
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        <location>
            <begin position="28"/>
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            <begin position="86"/>
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        <source>
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    </evidence>
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        <source>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="3129" mass="350179" checksum="073F568054CC2FA7" modified="2022-05-25" version="1">MSNSLDSFLTRIGDVTIERVTPRGSSRSSDRGDSCHDRGNKSSLNSRSLSDRDSEGTGGEASDVEEEKKNEPIGQDDLDEVHSDGSGDDMDLDETIDTEIGVRVDSERQHSESSFQDDDVEAVNILDTLPLEGAPIEGQEVTEADLLGKALLKDDDAESMDNDNIQSETQSGDEEDDEGGKRRGEDTSDSDPVKKKQKRDDNSDDPECELKSEKKLANMRRNIREVMDETQLDEATLAAQRQEMERLRRVQEQQKIIREVQRQIAINRHNNKNQSRVISLLQGKNDISTSLSESSSSSSSQVKLPNTVLFKVNSNSGSGGQISTGGSAGQVPRRPMENSRWQKGGRGGYQGMQTSISRLSNRSSPGQTVLQQRIRMMTPSVSISPVVPKKEPCDRSYFYSDSEASDAEIDDTAYEKELHPMHKASSTSSSQKPAKGKDVVTISSSSESSDDDCIVLSDPSGGEETDNEDDPSNSGMHTNDRYNVPDEHGRVLVNVGHPDTEPDVYLAPQVARVIKPHQIGGIRFLFDNIVESIERYSGSSGFGCILAHSMGLGKTLQVASFCDIFFRCTPAKTVLCIMPINTLQNWLAEFNMWLPYEDPNTVKSEVLPNNQKSESTGVDIKHEVKEENSNQTDISSNIPSRPISTESAHRSMSDSSSQIPVGMTGNSFGNSNYDSHSIQNNYYNDPMNKTGINLNTSNHPNYNNSTIQNPMHPSNLGQIDNFESMKKETDCHNTTSGSNSGFMIDDNNQPLNNMHEQVNNMIRGSLYSGADNSNNSMINNETQANVYSSYQNMPNNQFYGNNSQSPVPIKEEIKKEFISDHEITVKEEPKETTMKEENSSSDKEDVSNNKKPTPKVSTPFNVDAAVGMEVRPRHFRLHILNDSHKNMAARARVIQEWQKVGGVLLIGYELYRQLSLKKPNKGKKKRGQPLKDTIDIEEEDKNKGLLDDMHGALVNPGPDLVICDEGHRIKNSHASISMALKQMRTKRRIVLTGYPLQNNLLEYWCMVDFVRPNYLGSKSEFCNMFERPIQNGQCIDSTPQDIRLMRYRAHVLHALLEGFVQRRSHSVLQISLPRKEEYILLVRMTPFQRKLYDTFMNQVLKTRAVPNPLKAFAVCCKIWNHPDILFHFLRKRQANEEDDLDLEETIAEKSNSGGKRTKARQPKGESKRGKKVNATIKNKPAASVPPNSSLSSTSNETSTLDNSQSETKDNYSNFPQQNMNQNFTNSTQQNSYSQGYPNFRPNNPNNYYRNDQSTREYNNCYNNQGQQGFPNQASSYQSYQTNNLNYNQPQGYSQNPQVYNPRNEQTNNNNTPTATTNNSNNNNNNNNNSNNTSNNNSNNNSSSSNNSNINIINNNNNNNNNNNNSQKYPLNQPNTDFNNDQNNSNNYGMFPRQPYSFQDQNRNYPPNSNQPYSQNTGNTGQPSNYKSSVPSQSANIPMPDYSYGQSNQSQNYLSGSGANNNTSQIYSQNENQSIQNQPPVGYSTNQQNPPASQPLPPQTGYIGNQGAHLNQQNINPMLPNTGHGYPSPGRMNQPGHPIQNPLPGNPPNQMTSHLPNQNQPPYSSNPINSSNQPTSNAMTQNQPHGYLINQQQNQTHGYQATSQQNQYATQQGPASYPTNQQPSGSFPPGQTHGYPTDQQNLSPSKQGYPASHHVSTGNQGSTTYPSISQQCQMPPSVNQGHVYPTNQQVQLSSTQNQPHRYSQNQSSMPPNPPMGYNTSGKPPAGVQGEQQNLTENYHVNQTQQQNQDINNYATESSNQNQCKRSGENYSWQGNYSQPIRQDQCNNQYYRDPSANRYDNNYFPPQQNYEQNSSYDYNPSNSGTQPGLIGRNQKITGGYEKNTKDAGTINPGVQSQQPQNINPDTNYNGSNDSNNSKQNINSFQAINSCHNSFESIKEEDKEKDEISQVDKDKEDKSDDEILTKDEEKDLKNSPAGKEDGIPYEWATELMKGYVPGLIDASAKMSLFFCILEESILIGDRVLAFSQSLFTLNLIEDFLARNNFKYADGQTESWVRNVNYYRLDGSTSALEREKLINEFNHNPKIHLFLVSTRAGSLGINLVGANRAIVFDASWNPCHDTQAVCRVYRYGQQKPCYVYRLVTDNCLERKIYDRQISKQGMADRVVDQCNPDAHLSLKEATTLSWDWEEDSQVQDFSASKNDYTDEIMHCVLERHSSLLTKQPFHHESLLVDRKDKKLSQAEKRLARRGYELEKMAANNSKPSYNYVPGNTATRAGGLQIRAIRGGDTGVAPKPVASVRPMQQRGAESLGNRGVVGSRWIPAEVWQRQGMSAQEMTLPLDVVIPTNSPDKSSIVLKSGQRVMVLKSPKGIYMQLESGKIIAIRTALKINQQKREEEPKKATQRNMKPEVSFPLRNNSAISIIPKVGGNSTPAPRIPSRPNIGVNHRLNSDKELTKRSRAIPVPAMKVNLNNQVSLQRIAKGKFDSMDHSSVGENSNSSDSQPRTDQRVEEVRLEDIVAEANSNPAFSPSNQSRAANSDSESGLQKGFERKSRDYGISPITTDKTGETQHGEIESEITHKDNKTYEASCETKEPGGSLSTSNYRHQYPSQLNKHDNDEIIIEEPSSIVSQSPSLSTQPMQQQHLQQQQQQQQHQQQTVQKQQPSHQQQQQQQQQQQQQQQRQQQQPPPPPPPPLPPLQKQQSLQQPQPLQQQQQQQQQQMQQPLQQQQQQPLQQQALQPQKQPLQQQQLLQQQSLPMPIQPQQQPQQPPQQQQQQPLQQQQQQALQQQPLQQLVQHPQHHNQQPQPLPSQQSSQQTQPKPQPSPQQQPPPPPPPPPPPQPQPQPPQQPQQPQQPQQQQSQQPLQQSLYPQDSHSSRSLLRPQPHSQRPEISKNLMDSSSDSSVSAFTGPNVASIKDRAPDLQETASGESHGLPQTYPYTQYPRYYDYPDPRSRSITAPYGSYFPAVPPSHPTNARPSEITKLQPEIVKPSEERVPITTPAVYSQSPSTVIPPLPLVESSEAKNPDAISSMKIPTTTPSRTDPHITTAFSHPASNRYGGAYPSTPYNPYSQHYPAAPNASTSYPPSGAPGYAAYGGPAYNPDYAHMYSAFHGPPPAADPYMHRGYAPSPAAHPPNYYSPFPHPPPPPYPNYSFLPPYPNPNMPNMPSESQPPAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MRI1</accession>
    <name>A0A8J2MRI1_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">DNA 5'-3' helicase</fullName>
            <ecNumber evidence="16">5.6.2.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">DNA 5'-3' helicase FANCJ</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">HICCMSTLAB_LOCUS11587</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DEAD box helicase family. DEAH subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.3" evidence="16"/>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5103593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MRI1"/>
    <dbReference type="OrthoDB" id="19182at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016818">
        <property type="term" value="F:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990918">
        <property type="term" value="P:double-strand break repair involved in meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18788">
        <property type="entry name" value="SF2_C_XPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000731">
        <property type="entry name" value="Fanconi anemia group J protein homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006555">
        <property type="entry name" value="ATP-dep_Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045028">
        <property type="entry name" value="DinG/Rad3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014013">
        <property type="entry name" value="Helic_SF1/SF2_ATP-bd_DinG/Rad3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006554">
        <property type="entry name" value="Helicase-like_DEXD_c2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010614">
        <property type="entry name" value="RAD3-like_helicase_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013020">
        <property type="entry name" value="Rad3/Chl1-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00604">
        <property type="entry name" value="rad3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11472">
        <property type="entry name" value="DNA REPAIR DEAD HELICASE RAD3/XP-D SUBFAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11472:SF47">
        <property type="entry name" value="FANCONI ANEMIA GROUP J PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06733">
        <property type="entry name" value="DEAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13307">
        <property type="entry name" value="Helicase_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00488">
        <property type="entry name" value="DEXDc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00491">
        <property type="entry name" value="HELICc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51193">
        <property type="entry name" value="HELICASE_ATP_BIND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="13" id="KW-0234">DNA repair</keyword>
    <keyword evidence="9" id="KW-0347">Helicase</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0408">Iron</keyword>
    <keyword evidence="12" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="14" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="20">
        <location>
            <begin position="1"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="290"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="290"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="21">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00044969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00048954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00082714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="CAG5103593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="690" mass="79733" checksum="A3E0C1739EE18DF1" modified="2022-05-25" version="1" fragment="single">QYKTQFQEWINQQCNTEFNDVDMELEELPEKNKINDKDKVKAPVEEPKKVPKIYYGSRTHRQISQVIKELRRTAYSNAKMTILSSREFTCIQTSNRNKTELCNDLLDPIKKQGCPFYNESNKRVLSTYKSLDRSTIPQPWDIEELVEVGKEYGCCPYFAARNLLPEADIIFCPYNYLIDPNIRKSMQISLKDEIVILDEAHNIEDICRDSASDTFRVDELMEVIKECEHLITNVAKDKIPQYAPDGKSDQLTSKFWSSRELLELMSVNKLERQNHYQYKKAALEAIEKHNEAKEKSREQPNPHADPKKLVSDPTISPNTVRVLERLNLAIDMLTSDQFSSDFRALIREVPERFCQKIITRSPSASQKPRNQRIRMLDLLCMNPAVVFSPLANSARSIILASGTLSPTSSFSSELNTKFSHMLHANHVIPKEQVLVKAISQGPNNVALRATYANVNTWRFQDELGQVLLDVCQTVPFGVLCFFSSYTAMKTLTDRWWQNGVMTKLHQCKRILEEPRVSKDLSEVMREYRSIIRQCEEGTIEDSRITGVILFAVFRGKVAEGIDFSDNEARCVITIGIPYAVRNDPAVELKLAYNDFHTKERKLLRGTEWYAVQAFRALNQALGRCIRHKGDWGAILLIDDRFLLPQNQSYLPNWVKSMWSNRSKDYNLRENLKQFVSQRTKADNERKMLAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MSX5</accession>
    <name>A0A8J2MSX5_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS13007</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5107977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MSX5"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5107977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="99" mass="12167" checksum="D8829F23298E23B3" modified="2022-05-25" version="1">MEYAEQVYTNWSNTKEDKEELEWEDVKNIIYEAAKSTKMSTKSRNGRGWGNKRREWYNDECKEKREIVWKKLKMMLKESEKSDRKKEYAEAKKIYKKNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MT24</accession>
    <name>A0A8J2MT24_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">Ribosome biogenesis protein NOP53</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HICCMSTLAB_LOCUS12313</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="5">May play a role in ribosome biogenesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
            <location evidence="5">Nucleolus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
            <location evidence="5">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the NOP53 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5106545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MT24"/>
    <dbReference type="OrthoDB" id="5072at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008097">
        <property type="term" value="F:5S rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011687">
        <property type="entry name" value="Nop53/GLTSCR2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14211">
        <property type="entry name" value="GLIOMA SUPPRESSOR CANDIDATE REGION GENE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14211:SF7">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN NOP53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07767">
        <property type="entry name" value="Nop53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017302">
        <property type="entry name" value="Gltscr2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="271"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="303"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="321"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="339"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR017302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAG5106545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="475" mass="55448" checksum="C1D98FD6689DEB23" modified="2022-05-25" version="1">MKIINENEGLKKRKRVSKKNKISWRKNIDIQDVDNFLEDKRLEERLGKPFAKRTAAELFFVDTKPDESLGKLENVPEINSKAAYRVALRNSEPKCYSALKSTSAVPDPIAKRNRVRTPEERKNPVSRRIEALRRLNGQLKLKERDAIQNKRLEEARRKNRPKRGEYNLDAWEITPEQVTKMSSVMDTQWLSSDTVRHTLANSGLNKRKIPNSLYKKTSVLPAVEAPHPGLSYNPSYEDHQDLLRKVAEKEIKLIKEEKHIERVTTKMFKKVSPAEQTKNWLKESSEGLPNDDEDDSKKKTGDDNDDDDDDDDENTLDTPKSKKKQEKKTLKQRRKQKEQRKLKLDLAKGKMEKKKVSDLYRLRMLKKSMDAKERKKQKLRELREKLKAKKALEPKVLSKNKYEEPEIDFQMGHELKGNLRSTKPSTNLLSDRFKSLQQRSIVAPSNRILKLNKAKVKKFIKADHKITMPKVKKNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MTA4</accession>
    <name>A0A8J2MTA4_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS12508</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5106934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MTA4"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5106934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="100" mass="10959" checksum="BD366670FF350ECE" modified="2022-05-25" version="1">MLSQAQDLALKQGSIKAGESLCVTSGWENTVLAIRERITRHNIFNSVSIHVTKIQEDPSTRNCPELTTTHSANTRTPCSRTPATHSRMDEDAVALNDPEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MTI9</accession>
    <name>A0A8J2MTI9_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS13582</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5108946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MTI9"/>
    <dbReference type="OrthoDB" id="10587481at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="105"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5108946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="114" mass="12601" checksum="19BB29F5A000D457" modified="2022-05-25" version="1" fragment="single">LLFTIIYLSFPSQLIPEGYLPVSMFPFHPASSNNLRSGISIPRGHSAAKEIILPNDCYWIAQNVGYPVTNISDPNSRPSFVYQNTRIHPEASRQANQSPDKKSSGSDTSYSSVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MTU3</accession>
    <name>A0A8J2MTU3_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DNA replication complex GINS protein PSF2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HICCMSTLAB_LOCUS7656</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subunit">
        <text evidence="5">Component of the GINS complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the GINS2/PSF2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5095332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MTU3"/>
    <dbReference type="OrthoDB" id="1938138at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071162">
        <property type="term" value="C:CMG complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000811">
        <property type="term" value="C:GINS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11712">
        <property type="entry name" value="GINS_A_psf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21694">
        <property type="entry name" value="GINS_B_Psf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.1020:FF:000001">
        <property type="entry name" value="DNA replication complex GINS protein PSF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.5.50:FF:000001">
        <property type="entry name" value="DNA replication complex GINS protein PSF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.5.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021151">
        <property type="entry name" value="GINS_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036224">
        <property type="entry name" value="GINS_bundle-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007257">
        <property type="entry name" value="GINS_Psf2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056784">
        <property type="entry name" value="PSF2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12772">
        <property type="entry name" value="DNA REPLICATION COMPLEX GINS PROTEIN PSF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12772:SF0">
        <property type="entry name" value="DNA REPLICATION COMPLEX GINS PROTEIN PSF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25005">
        <property type="entry name" value="PSF2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05916">
        <property type="entry name" value="Sld5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028998">
        <property type="entry name" value="GINS_Psf2_subgr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158573">
        <property type="entry name" value="GINS helical bundle-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160059">
        <property type="entry name" value="PriA/YqbF domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA replication complex GINS protein PSF2 N-terminal" evidence="7">
        <location>
            <begin position="2"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="domain" description="GINS subunit" evidence="6">
        <location>
            <begin position="65"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR028998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF05916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF25005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG5095332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="187" mass="21460" checksum="892919D591F092F9" modified="2022-05-25" version="1">MDPHEVEFLGEKKQVEIVPNFNLGQVHLISGSIGPFRAGLPVNVPIWLAVTLKQQQKCRILSPDWMQLENLEAIKENEKQSKDFTRMPNDHYMDQAHILLNAASDDLVEVDSIRTSIKDIWDTRMSKLRTLIDELFRDENGEHALLNNLTLMEITSVRSLLPNAMDQLQRIKTSEDRVRGSQTQDSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MTW4</accession>
    <name>A0A8J2MTW4_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to Fam89b: Leucine repeat adapter protein 25 (Mus musculus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS13857</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAM89 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5109221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MTW4"/>
    <dbReference type="OrthoDB" id="1681166at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039499">
        <property type="entry name" value="LURA1/LRA25"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46949:SF1">
        <property type="entry name" value="AT07979P2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46949">
        <property type="entry name" value="LEUCINE REPEAT ADAPTER PROTEIN 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14854">
        <property type="entry name" value="LURAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="384"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="466"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="71"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="94"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="396"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5109221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="486" mass="54458" checksum="1A93905DEB0A950E" modified="2022-05-25" version="1">MSMKLASMQQQQQQRPHAPPVPPRPSKQVVVEALKRSSTRLPCPTRQAPPPPTNVRPWRQLDYPSSNNRFKPVEKSHDVNPVKDTHQKKLPGFNNNDNNNCNNINNNIDNNDNNTISSDNNSNENESSKKLIKNKITKSNDVYENNFDVINQEPNLVDNQNNSVNNYENIVISNNQERKLPPTTNQCIILPAVINKLENNNLSTELSVGENTREIISKEIHNKLITSPDSPVKSITAPTTTIVITESDNKLQVLKKQNSVENLLASSVSNASSDECATIVVVEKPNEDKISISSEEEKKNNIHHQDWLESGIRYSSTKITIPAGDKSLNDGVLNSTTHHFLYNYSKTRPGNNVTSLYDKIAMSSLQGLPPLPRSLSGLYLNEEFRETNEPPPPPMRSSSKTPKVGKTIQSSNSRPSLSPGRQLTTLDSQLAILRKEMFGLRQLDLSLLSQLWSLNESIQEFRQLVQDHDDRAPSPSPSSEEVILYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MVU3</accession>
    <name>A0A8J2MVU3_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RecQ-mediated genome instability protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HICCMSTLAB_LOCUS9228</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RMI1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5099775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MVU3"/>
    <dbReference type="OrthoDB" id="341511at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016604">
        <property type="term" value="C:nuclear body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031422">
        <property type="term" value="C:RecQ family helicase-topoisomerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000712">
        <property type="term" value="P:resolution of meiotic recombination intermediates"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.770">
        <property type="entry name" value="RecQ-mediated genome instability protein Rmi1, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049363">
        <property type="entry name" value="RMI1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042470">
        <property type="entry name" value="RMI1_N_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013894">
        <property type="entry name" value="RMI1_OB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14790:SF15">
        <property type="entry name" value="RECQ-MEDIATED GENOME INSTABILITY PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14790">
        <property type="entry name" value="RECQ-MEDIATED GENOME INSTABILITY PROTEIN 1 RMI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08585">
        <property type="entry name" value="RMI1_N_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21000">
        <property type="entry name" value="RMI1_N_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01161">
        <property type="entry name" value="DUF1767"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RMI1 N-terminal" evidence="5">
        <location>
            <begin position="16"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="domain" description="RecQ mediated genome instability protein 1 OB-fold" evidence="4">
        <location>
            <begin position="67"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="187"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="225"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="447"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="194"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="233"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="451"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF21000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAG5099775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="630" mass="71306" checksum="63CC208AF08C5B30" modified="2022-05-25" version="1">MPFNFENVKIQLHAEHYLMNDCWLKDCVGYYSTEVNPQAVQAEIVKFVKDQWILSDLREINDQRGCLPENLAQQKMITLPGTYILQVEKGYDISTSKYKQVEKIRNVSSENIEVTEAEKNPTWEPKTKRMMYLYLTDGKQEVTAMEHKPIPFLKDHLLPGYKIMIKGPVILRRSVIMLESKNCSHVGGEIENPYNDKKSDDKNEPLSLDEGMDIDMDALDQIEKKYDDNSGVKAPKTKPTSATTSRTKRRESVLLDSLPVCFDSIEQVENEFADDFDDMIGMIDEANLNVVGGGDKDVEIEEVKIEAENTRAGAFPEDDFPTDLEFDEFEFDSFPYEKTTNMLEEDKVVSESLNNVVDASRSTIVSNATASSCVKSNVTISNAKNNVTGSNVKNNPTNITKSNFNFKSSNDSSHKSIRQSSETVNKIPEKMTPSFSGSEVCRGSPMKNDNKISPSNNPVINPFVTPSKNPPKTIRKETPKRNLKNVQKITDFMKKSVTPKSDESKLSSALIDNYDLIKDIEKLMPVSREIDKKIKGTIISLANLERRDPNWYLQGILNRLIGFNLAEFSQMKKLKKTDPEVANKLRQGLRGAEFKLSHLHTLLRCKLLPNNPVLFVESMLDLTGGQRKEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MVV5</accession>
    <name>A0A8J2MVV5_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10 11">Ribosome biogenesis protein NSA2 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">HICCMSTLAB_LOCUS9259</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Involved in the biogenesis of the 60S ribosomal subunit. May play a part in the quality control of pre-60S particles.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 11">Component of the pre-66S ribosomal particle.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
            <location evidence="1 11">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the eukaryotic ribosomal protein eS8 family. Ribosome biogenesis protein NSA2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5099837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MVV5"/>
    <dbReference type="OrthoDB" id="1847590at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030684">
        <property type="term" value="C:preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11381">
        <property type="entry name" value="NSA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.310:FF:000001">
        <property type="entry name" value="NSA2, ribosome biogenesis homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.310">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.50.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039411">
        <property type="entry name" value="NSA2_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002906">
        <property type="entry name" value="Ribosomal_eS31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022309">
        <property type="entry name" value="Ribosomal_Se8/biogenesis_NSA2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12642">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN NSA2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01599">
        <property type="entry name" value="Ribosomal_S27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01201">
        <property type="entry name" value="Ribosomal_S8e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01402">
        <property type="entry name" value="Ribosomal_S27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="Zn-binding ribosomal proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 11" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="7" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4 11" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="5 11" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Small ribosomal subunit protein eS31" evidence="14">
        <location>
            <begin position="253"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="18"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="51"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="18"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00068584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU367114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM01402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CAG5099837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="307" mass="35723" checksum="EABDEBA169344B93" modified="2022-05-25" version="1">MPQNEYVERHQKLYGRRLDYEERKRKREAREPHKRAERARTLRGIKAKIFNKERRNEKIQMKKKIKAHEEKKVKEQSENAPEGALPVYLLDRDVQQRSKVLSNMIKQKRKEKAGKWDVPIPKVKAQSESEVFKIVKSGKTRRKAWKRMVTKVTYVGENFTRKPPKFERFIRPMALRFRKAHVTHPELKATFHLPIIGVKRNPSSVMYTTLGVITKGTIIEVNISELGLVTQTGKVVWGKYAQVTNNPENDGCINAVLLVDENGKIHRLRRECPSEQCGAGVFMAAMEDRHYCGKCGYTLVFNKPEDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MX73</accession>
    <name>A0A8J2MX73_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Similar to ptf1a: Pancreas transcription factor 1 subunit alpha (Xenopus laevis)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HICCMSTLAB_LOCUS11268</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5102956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MX73"/>
    <dbReference type="OrthoDB" id="10048995at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032502">
        <property type="term" value="P:developmental process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11417">
        <property type="entry name" value="bHLH_TS_PTF1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.280.10:FF:000035">
        <property type="entry name" value="Pancreas-specific transcription factor 1a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050283">
        <property type="entry name" value="E-box_TF_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23349:SF112">
        <property type="entry name" value="48 RELATED 1, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23349">
        <property type="entry name" value="BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTOR, TWIST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="5">
        <location>
            <begin position="46"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAG5102956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="149" mass="17345" checksum="29E01F92426C7122" modified="2022-05-25" version="1">MFSMLRNVNQCIHQSACIACRYQKLPNLIYEGNLSLSMKRPSHIIQQRHAANLRERKRMQSINDAFEGLRAHLPTLPYEKRLSKVDTLKLAIGYISFLTELVNGNQNSASYKHGTIIKSRNQDCYHKIIVTSKYASLPYYFMFIYGQIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MXJ6</accession>
    <name>A0A8J2MXJ6_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to AKAP17A: A-kinase anchor protein 17A (Homo sapiens)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS10725</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5101858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MXJ6"/>
    <dbReference type="OrthoDB" id="1918237at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056852">
        <property type="entry name" value="AK17A/B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12484:SF4">
        <property type="entry name" value="A-KINASE ANCHOR PROTEIN 17A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12484">
        <property type="entry name" value="B-LYMPHOCYTE ANTIGEN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25015">
        <property type="entry name" value="RBD_AKAP-17A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="402"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="298"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="408"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="432"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="472"/>
            <end position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5101858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="483" mass="56117" checksum="C49C03287A113FDC" modified="2022-05-25" version="1">MSKDKKVGDGKISGEDVNGLRCCRDLSDIVPLYSAKGLYLKPIAKINISVNLPQLKTPGKTLSTWEVMEKLRLLIRPDEFASLKVSKSTLEFLRLEADLTDKCRMAQVLSRLEGQRLNLAGFASILKVRAVEAKDDFPSKHNWDSFFRDAKHMNELKPGERPDTIYISGLPVKWFSEDGGKTPSEPLCMKIFKKWGIIRRIDVPAADPYRSRMRLDNNINKKSNLNDGIFFDVYIQYIEYVDFVKLMDSLRGMKVLKKEDNNYLTAIVKVDFDKTKHMSDNSVSRREFERKRLIAQDHMAMEKLRKREEAEAKKKEEELKKEAADKDAKYIRRKKREEKRKRKALTMFRKQEEDKVSMKIAREEQKLIKAQRQLESIRLLDELFDRIKVRFVDIKLEKGEITIGDKSNSNEKSKDADEKNSDGNDKSEKKDKKSKKKKSKKVKKKKKKDKKNVTSSSDDSDEETNKKKLKSTLANKSDSYPEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MXQ0</accession>
    <name>A0A8J2MXQ0_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS10921</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5102250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MXQ0"/>
    <dbReference type="OrthoDB" id="8113373at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20905:SF32">
        <property type="entry name" value="ARYLALKYLAMINE N-ACETYLTRANSFERASE-LIKE 7, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20905">
        <property type="entry name" value="N-ACETYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5102250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="609" mass="68050" checksum="3F252B46CFFF3824" modified="2022-05-25" version="1">MVWSRPPGDPRVWSTVEAVKPDGKKVKFIIQEIPPSRYEEALDHLCTVFITSEPICRSINLIDDAESVAEVRAFWTTALNQGISIGAYEVDQNNQISKFAGMNVLTMGDKDDDKTITPVTSTMSGSQKLLTFMQNLSAEVDFCKKWGVDYYLGAAGLDVDTNYRRLGLGTHLLLARDKIAKAYNIPVSSTFFTSPTSQKTAKKAGFEVFWEKRWNDIVDDKGNVIFPGLGDTYCKVMEKKFKVWSTVEAVKPDGKKVKFIIQEIPPSRYEEALDHLCTVFITSEPICRSINLIDDAESVAEVRAFWTTALKQGISIGAYEVDQNNEISKFAGMNVLVMSNKGEDKTITPMTSTMSKNEKLLTFLHNLFAEVDFCKKWGVDYYLSAAGLDVDTNYRRLGLGTHLLLARDKIAQAYNILVSATFFSSPVSQKTAEKAGFKTFWEKPVKPDGTKVKFIIQEIPPNRYEEALDHLCTDFITSEAMCRSLNLIDDKKSVAELRSIWAIILNQGISVDAYEVDKNNLISTLAGLNVLMIQYNNAVKTIAPITSTISKREKLLATVRNCSMEANSSRKRAAGFYLKAAGLVVDPNYRRLGLGTHLLLARDKIAEEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MZC6</accession>
    <name>A0A8J2MZC6_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Similar to zc4h2: Zinc finger C4H2 domain-containing protein (Danio rerio)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HICCMSTLAB_LOCUS12646</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5107232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MZC6"/>
    <dbReference type="OrthoDB" id="20865at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045666">
        <property type="term" value="P:positive regulation of neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044069">
        <property type="entry name" value="ZF_C4H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018482">
        <property type="entry name" value="Znf-C4H2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31058">
        <property type="entry name" value="ZINC FINGER C4H2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31058:SF2">
        <property type="entry name" value="ZINC FINGER C4H2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10146">
        <property type="entry name" value="zf-C4H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51896">
        <property type="entry name" value="ZF_C4H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C4H2-type" evidence="3">
        <location>
            <begin position="207"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="160"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="229"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="23"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="192"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="234"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG5107232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="248" mass="28609" checksum="AAEF701507809456" modified="2022-05-25" version="1">MSAAETTVIFAKLEALKDIRSKTVQLEKMKQRIIQEVEQTEQEDKCLMEYKQEMDLLMQEKMAHVEELRQIHADINAMESVIKQAEEARNRAREHAKLIHNNEYQPLKHDIDRMRREYLGLERLPELYETETDLIAPDYFDRPMQKAEWRVEVRGEDLMQPLGLHGHPGHPGGSTPFLAPQPLQGPSKPEPRPLPPATGPPAPTFRQQPPPMKSCLSCHQQIHRNAPICPLCKAKSRSRNPKKPKKKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-04-29" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>B1GS91</accession>
    <name>B1GS91_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein eL22</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">60S ribosomal protein L22</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">rpL22e</name>
        <name evidence="7" type="ORF">HICCMSTLAB_LOCUS2723</name>
        <name evidence="8" type="ORF">rl0AAD1YB17</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2008" name="Arch. Insect Biochem. Physiol." volume="67" first="172" last="187">
            <title>Bracovirus Gene Products Are Highly Divergent From Insect Proteins.</title>
            <authorList>
                <person name="Bezier A."/>
                <person name="Herbiniere J."/>
                <person name="Serbielle C."/>
                <person name="Lesobre J."/>
                <person name="Wincker P."/>
                <person name="Huguet E."/>
                <person name="Drezen J.M."/>
            </authorList>
            <dbReference type="PubMed" id="18348209"/>
            <dbReference type="DOI" id="10.1002/arch.20219"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <tissue evidence="8">Ovary</tissue>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL22 family.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001117">
        <property type="protein sequence ID" value="CAG5078386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AM492671">
        <property type="protein sequence ID" value="CAM34502.1"/>
        <property type="molecule type" value="mRNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B1GS91"/>
    <dbReference type="OrthoDB" id="10259820at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1360.210:FF:000001">
        <property type="entry name" value="60S ribosomal protein L22 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002671">
        <property type="entry name" value="Ribosomal_eL22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038526">
        <property type="entry name" value="Ribosomal_eL22_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10064">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10064:SF0">
        <property type="entry name" value="FI24544P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01776">
        <property type="entry name" value="Ribosomal_L22e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 8" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00040613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00041214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAG5078386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAM34502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="145" mass="16875" checksum="CE2175D1E97247B0" modified="2008-04-29" version="1">MAPQAKISTKKPVPKKTGAPKKNQLRGKAQKKKVSLSFTIDCTHPVEDNIMDVASFDKYMKERIKINGKTGNLGNLVNIERNKNKLIINSDTELSKRYLKYLTKKFLKKHKLRDWLRVVSKDKNTYELRYFQITSQEDDDEEDAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>S6CWG7</accession>
    <name>S6CWG7_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Cc_single_2.3b</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">CcBV_2.3b</name>
        <name evidence="6" type="ORF">HICCMSTLAB_LOCUS6100</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2013" name="Philos. Trans. R. Soc. Lond., B, Biol. Sci." volume="368" first="20130047" last="20130047">
            <title>Functional endogenous viral elements in the genome of the parasitoid wasp Cotesia congregata: insights into the evolutionary dynamics of bracoviruses.</title>
            <authorList>
                <person name="Bezier A."/>
                <person name="Louis F."/>
                <person name="Jancek S."/>
                <person name="Periquet G."/>
                <person name="Theze J."/>
                <person name="Gyapay G."/>
                <person name="Musset K."/>
                <person name="Lesobre J."/>
                <person name="Lenoble P."/>
                <person name="Dupuy C."/>
                <person name="Gundersen-Rindal D."/>
                <person name="Herniou E.A.Drezen.J.M."/>
            </authorList>
            <dbReference type="PubMed" id="23938757"/>
            <dbReference type="DOI" id="10.1098/rstb.2013.0047"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5092381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="HF586473">
        <property type="protein sequence ID" value="CCQ71151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S6CWG7"/>
    <dbReference type="OrthoDB" id="7700695at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16448">
        <property type="entry name" value="RING-H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="1 3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="5">
        <location>
            <begin position="23"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="95"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAG5092381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCQ71151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="422" mass="46950" checksum="19B6503504ED9953" modified="2016-04-13" version="1">MAGDKTDKTNKEKDKAGDKAEYCGLCCRQISDTASAESTRASCKHIFHTLCIKVRYCLQTKADAKAFVAVKCPVCPLPTDSAAVLAQINAKLDLLTTMNDKLTGLTERVDKLQDTCGTLNDRVTKLEAEGLPDIGSSNSAAFIKQVADQVSSTVKASSDINDEIRQLQLESTLLNDQFVVSGFKEDASEDLLDMVVRLGSMMGVPDLNRDRFQYADRIGKKGPGARCREIVVKCKSPQTVNNFIAVRRDLKELTANVIIPGMPRVPIYVSRRYPQSLYKLRRLLIEKYPAINKRSTWIASTCVCVRPTVGSEPIKAYPSTDLDHIQELFRLHRNDRRLRHGGGVALFVKNTLSSRVVACSSNLSDFELEYIAVELVAESSRKILVCVIYRPPRAALFDAFEQDFDRLLPFYNNIVIIGDLAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>S6D2W0</accession>
    <name>S6D2W0_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cc_bv7.7_36.4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">bv7-7</name>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS6107</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Philos. Trans. R. Soc. Lond., B, Biol. Sci." volume="368" first="20130047" last="20130047">
            <title>Functional endogenous viral elements in the genome of the parasitoid wasp Cotesia congregata: insights into the evolutionary dynamics of bracoviruses.</title>
            <authorList>
                <person name="Bezier A."/>
                <person name="Louis F."/>
                <person name="Jancek S."/>
                <person name="Periquet G."/>
                <person name="Theze J."/>
                <person name="Gyapay G."/>
                <person name="Musset K."/>
                <person name="Lesobre J."/>
                <person name="Lenoble P."/>
                <person name="Dupuy C."/>
                <person name="Gundersen-Rindal D."/>
                <person name="Herniou E.A.Drezen.J.M."/>
            </authorList>
            <dbReference type="PubMed" id="23938757"/>
            <dbReference type="DOI" id="10.1098/rstb.2013.0047"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5092388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="HF586473">
        <property type="protein sequence ID" value="CCQ71157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S6D2W0"/>
    <dbReference type="OrthoDB" id="7437131at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036441352" evidence="1">
        <location>
            <begin position="23"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5092388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCQ71157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="145" mass="15621" checksum="4291BB419F634D4F" modified="2016-04-13" version="1">MFAKSTITLFVLAVGLSSLLSGNSIGSASAYPRPDEPSMNIDLDDPNDVKLFEDLNHMREGNNFGALTVLRNNVIQGSNTTGENHLGTETDQIHIMVGGKLPEGRHTYGGATYGSGNTIQESDSSSKNFLGSRLTQEKITYNVKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-10-16" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>S6D310</accession>
    <name>S6D310_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Cc_p94.1_7.1b</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">p94-like1</name>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS6248</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Philos. Trans. R. Soc. Lond., B, Biol. Sci." volume="368" first="20130047" last="20130047">
            <title>Functional endogenous viral elements in the genome of the parasitoid wasp Cotesia congregata: insights into the evolutionary dynamics of bracoviruses.</title>
            <authorList>
                <person name="Bezier A."/>
                <person name="Louis F."/>
                <person name="Jancek S."/>
                <person name="Periquet G."/>
                <person name="Theze J."/>
                <person name="Gyapay G."/>
                <person name="Musset K."/>
                <person name="Lesobre J."/>
                <person name="Lenoble P."/>
                <person name="Dupuy C."/>
                <person name="Gundersen-Rindal D."/>
                <person name="Herniou E.A.Drezen.J.M."/>
            </authorList>
            <dbReference type="PubMed" id="23938757"/>
            <dbReference type="DOI" id="10.1098/rstb.2013.0047"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5092602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="HF586475">
        <property type="protein sequence ID" value="CCQ71306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S6D310"/>
    <dbReference type="OrthoDB" id="8120898at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5092602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCQ71306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="470" mass="56037" checksum="8B7F9B52BAB0D497" modified="2013-10-16" version="1">MLSFLIRLKLHNNNLQIYKNILHSEILGRILQKYILIKFWCHLSRLILFEAQNNNRQYFEKNILRIKIFITIHSSNFLEPQSLTIGLTNANSRIVEVSVSDELMSLFIINYRKFTRIWLLLSCMTVDLTLNKRNSLHQNLYGISTTLPTALWYCVELSSGIFKNDPQHYKQERLRGYYSVARYMIEILTWFNYDLDLKPIEKRKELLSYVMTLKKIQKRRKKIYYLLEKIFKTVDGFLVSEIEKSSNLYKLNYLKLNHKGILRDDILEEKVHLNDFVHLMHFEGDLEASEAGTGTFDICEKTFRPYFAIDQDKSFYTELVKNTKKVVISNDDDKDKIKVTFEPINSLEFDRVLSLYKLFIDCVKESKKYPTLPKYVDNISKRKKFHMDLVTLFPSNVYFDIKDVYERYQKVVKKVRVNEFLKVYESHVGRMERIKAEKRVKFSSDSEISKFITSEELKVKLNSNHTRKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-10-16" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>S6D4S3</accession>
    <name>S6D4S3_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Cc_bv8.15_CcPL2.092</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">bv8-15</name>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS6147</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Philos. Trans. R. Soc. Lond., B, Biol. Sci." volume="368" first="20130047" last="20130047">
            <title>Functional endogenous viral elements in the genome of the parasitoid wasp Cotesia congregata: insights into the evolutionary dynamics of bracoviruses.</title>
            <authorList>
                <person name="Bezier A."/>
                <person name="Louis F."/>
                <person name="Jancek S."/>
                <person name="Periquet G."/>
                <person name="Theze J."/>
                <person name="Gyapay G."/>
                <person name="Musset K."/>
                <person name="Lesobre J."/>
                <person name="Lenoble P."/>
                <person name="Dupuy C."/>
                <person name="Gundersen-Rindal D."/>
                <person name="Herniou E.A.Drezen.J.M."/>
            </authorList>
            <dbReference type="PubMed" id="23938757"/>
            <dbReference type="DOI" id="10.1098/rstb.2013.0047"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5092456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="HF586473">
        <property type="protein sequence ID" value="CCQ71201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S6D4S3"/>
    <dbReference type="OrthoDB" id="7671380at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5092456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCQ71201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="136" mass="15448" checksum="A78DB93D5427845C" modified="2013-10-16" version="1">MENNYATITHVELKRDILIPLEWPIRGIERTVLYIAQKMIMEPDAEKCFLEVQNIPAKLLRRPTRTGFINIFQKVSHEEIEDAFRCDVASPKDDRSVKIDIASGSQSISKLSVADAKRMSPKTQTSYVGVIPPGYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-10-16" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>S6D4S8</accession>
    <name>S6D4S8_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Cc_bv9.6_28.18</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">bv9-6</name>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS6167</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Philos. Trans. R. Soc. Lond., B, Biol. Sci." volume="368" first="20130047" last="20130047">
            <title>Functional endogenous viral elements in the genome of the parasitoid wasp Cotesia congregata: insights into the evolutionary dynamics of bracoviruses.</title>
            <authorList>
                <person name="Bezier A."/>
                <person name="Louis F."/>
                <person name="Jancek S."/>
                <person name="Periquet G."/>
                <person name="Theze J."/>
                <person name="Gyapay G."/>
                <person name="Musset K."/>
                <person name="Lesobre J."/>
                <person name="Lenoble P."/>
                <person name="Dupuy C."/>
                <person name="Gundersen-Rindal D."/>
                <person name="Herniou E.A.Drezen.J.M."/>
            </authorList>
            <dbReference type="PubMed" id="23938757"/>
            <dbReference type="DOI" id="10.1098/rstb.2013.0047"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5092496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="HF586473">
        <property type="protein sequence ID" value="CCQ71220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S6D4S8"/>
    <dbReference type="OrthoDB" id="10445747at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5092496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCQ71220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="116" mass="13900" checksum="05A5AD46C0804076" modified="2013-10-16" version="1">MINDALKKFAIVKFDVISTYGTNPYKVVPFKWVKDTDKNKVLAQYPSKDDVFKEFENILKCNEPKSRWIECSGSLEYLTNSYLDGLIFIKTRRNEFIPEELMFLDYTERFYIQNDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2E497</accession>
    <name>A0A8J2E497_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ADAM10 endopeptidase</fullName>
            <ecNumber evidence="4">3.4.24.81</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">HICCMSTLAB_LOCUS2437</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endopeptidase of broad specificity.</text>
            <dbReference type="EC" id="3.4.24.81"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Membrane</location>
            <topology evidence="3">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="18">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="24">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.81" evidence="4"/>
    <dbReference type="EMBL" id="CAJNRD030001117">
        <property type="protein sequence ID" value="CAG5077376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2E497"/>
    <dbReference type="OrthoDB" id="2149267at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006509">
        <property type="term" value="P:membrane protein ectodomain proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007219">
        <property type="term" value="P:Notch signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04270">
        <property type="entry name" value="ZnMc_TACE_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.70.10:FF:000002">
        <property type="entry name" value="disintegrin and metalloproteinase domain-containing protein 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.70.10">
        <property type="entry name" value="Disintegrin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034025">
        <property type="entry name" value="ADAM10_ADAM17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049038">
        <property type="entry name" value="ADAM10_Cys-rich"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051489">
        <property type="entry name" value="ADAM_Metalloproteinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001762">
        <property type="entry name" value="Disintegrin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036436">
        <property type="entry name" value="Disintegrin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001590">
        <property type="entry name" value="Peptidase_M12B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45702">
        <property type="entry name" value="ADAM10/ADAM17 METALLOPEPTIDASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45702:SF3">
        <property type="entry name" value="KUZBANIAN-LIKE, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21299">
        <property type="entry name" value="ADAM10_Cys-rich"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00200">
        <property type="entry name" value="Disintegrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13574">
        <property type="entry name" value="Reprolysin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00050">
        <property type="entry name" value="DISIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57552">
        <property type="entry name" value="Blood coagulation inhibitor (disintegrin)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50215">
        <property type="entry name" value="ADAM_MEPRO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50214">
        <property type="entry name" value="DISINTEGRIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0165">Cleavage on pair of basic residues</keyword>
    <keyword evidence="16" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="17" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 18" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 21" id="KW-0732">Signal</keyword>
    <keyword evidence="7 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 20" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="11 18" id="KW-0862">Zinc</keyword>
    <keyword evidence="15" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="21">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035275122" description="ADAM10 endopeptidase" evidence="21">
        <location>
            <begin position="21"/>
            <end position="1097"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="709"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M12B" evidence="23">
        <location>
            <begin position="260"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="domain" description="Disintegrin" evidence="22">
        <location>
            <begin position="488"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="171"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="776"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="890"/>
            <end position="913"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="955"/>
            <end position="995"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1016"/>
            <end position="1077"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="179"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="793"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="19">
        <location>
            <begin position="824"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="955"/>
            <end position="966"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="972"/>
            <end position="995"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="1050"/>
            <end position="1076"/>
        </location>
    </feature>
    <feature type="active site" evidence="18">
        <location>
            <position position="424"/>
        </location>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="423"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="427"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="433"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS50215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="CAG5077376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="1097" mass="122397" checksum="6C390B75FF03F4BB" modified="2022-05-25" version="1">MPTATIQWALAILSLVLVDASPLHPLPPHAGITKRSYIGYYEPVSYDSAILREHRNRVRRDVSEDSKVQPIRMDNETCSGYCICKRCRTNGPIAFDSSHSYTGTVAEDDNAIVEGIVTKDGLFDGSVSTTSEDYYFEPTSRYLTRTEDSESEENTSPTYHTIAYRASDVVAPPQPSRCASKELHEGKLNKSEKKKNESFEPYFEQLQDHEIRDNGGYYLRQINRRHINKGGSNIQFIDGINRDRFTRHLHKRATVDPRKTTCMLYLQADHQFFARYGTEEACIEVMTRHVQRVNSIYKHTDFNQDGRPDNISFMIKRVKVHNADAMKDSHYRFPNSYGVEKFLELFSEEDYDAFCLAYMFTYRDFEMGTLGLAWTGDLKNAGGVCEKNGHYRGSMKSLNTGIVTLLNYGKHVPPAVSHVTLAHEIGHNFGSPHDPEQCTPGGEDGNFIMFARATSGDKRNNNRFSPCSLNAINPVLNTKARSPKEPQASLCGNGVVEDGEECDCGWEEDCRDSCCFPQRRYPPAEEKPCTLTPRSICSPSQGPCCTTDCKLKFSDKCREDNGCRDASFCDGRSPHCPPSINKPNKTICNRELVCFMGECTGSICLAYGLESCQCIPGPNDSPTKACELCCRIPGGNQPCLSSFDWNSPPYDIPDMFSKPGTPCNDYNGYCDVFQKCREVDPSGPLATLRKLLLSDESLATFRRWVIDHWYAVALLILATISLLVATIRFLGKRSNPKLKSVTIIHSSTTETVRLPPEGAEGVTVHPPAVRAKLPLNQKVREKRRQSKQKDLLTNNPTNNSSNNKTAKITTMMRRRSKQPPELAKKKKKKKKRVVPIVVEEPNRKCIEVSTALPSIADQQVAPIPEETPTKVSSKDVGLKKKRKKKEVIDYSMAQADEDNEVTSSDNSDPKSKVRSWLLASHGRIEQANIAALTKSKSTPVGLAGSPAVTPMVRTTAAAAAATSRTRPLNSKRTADVKNQRVSDSGRAKDPTSERVRLQIVYKPPFKFSVKFKKTDKVQRISSSRKNTKSSHPRTAVLVRTSNKKDKLRKGQQTSTSKGVNATGRPTESSHAANSDLHTVPSDLEVLLSESEFLFSDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2E807</accession>
    <name>A0A8J2E807_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Quinone] (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HICCMSTLAB_LOCUS2289</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001117">
        <property type="protein sequence ID" value="CAG5076820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2E807"/>
    <dbReference type="OrthoDB" id="269227at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF208">
        <property type="entry name" value="RE36204P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035321533" evidence="4">
        <location>
            <begin position="23"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="5">
        <location>
            <begin position="51"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase C-terminal" evidence="6">
        <location>
            <begin position="454"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="542"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="586"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="267"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF05199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAG5076820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="607" mass="68048" checksum="45A712AFEDE66866" modified="2022-05-25" version="1">MNIKVIKTLTILLLAVIKSANSKSLFELMMSYGLQKSFDIITTPLPTVEQYDFIIIGAGSGGSTLANRLSENRKWKVLLLEAGKPEGILNQIPILVSNFQQTDYNWGYRVEPQKNACLGMKDRRCTWPRGKSLGGTSTLNYMIHTRGNRVDYDTWEAAGNNGWSYDDVLPYFIKSERFKIPEPYNASYHGKDGYLCVEHIPYHMPLSTEFLKAGKKLGWEIIDYNGPEQIGFSYLQVNMDRGARCSASRAYLKVRRPNLEIVTLARVTKILIDSDRRAYGVEYIKDGKTRQIRATKEVISSAGTIDSAKLLMLSGIGPRDHLEDLGIPVIKDAKVGYNLLEHVGFLGLTFLVNASVTLLEKTIIKPQNALQYMIDRSGPLSIPGGAEAIAFIRTKYAQDSRPDLELLFVSGSIHSDNGVAVRKGHGITDELYNAVFKPIENRDAWSIWPIMQQPRSVGKITLRSKNPFDDPIIQPNFFTHPADIEIILEGVKHAIKIAATEEFQKYNSRLHTIKIPGCREFDFASDDYFRCAIRHLPSMMNHEVGTVKMGPPEDPTAVVDSQLRVYGVKGLRVVDASIMPTMPIGHVNAGIFMIGEKAADMIKQMWN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2EB62</accession>
    <name>A0A8J2EB62_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Similar to Xpc: DNA repair protein complementing XP-C cells homolog (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HICCMSTLAB_LOCUS893</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the XPC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001114">
        <property type="protein sequence ID" value="CAG5074121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2EB62"/>
    <dbReference type="OrthoDB" id="300780at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000111">
        <property type="term" value="C:nucleotide-excision repair factor 2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071942">
        <property type="term" value="C:XPC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.2460:FF:000001">
        <property type="entry name" value="DNA repair protein Rad4 family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2460">
        <property type="entry name" value="Rad4, beta-hairpin domain BHD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004583">
        <property type="entry name" value="DNA_repair_Rad4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018328">
        <property type="entry name" value="Rad4_beta-hairpin_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042488">
        <property type="entry name" value="Rad4_BHD3_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12135:SF0">
        <property type="entry name" value="DNA REPAIR PROTEIN COMPLEMENTING XP-C CELLS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12135">
        <property type="entry name" value="DNA REPAIR PROTEIN XP-C / RAD4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10405">
        <property type="entry name" value="BHD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01032">
        <property type="entry name" value="BHD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rad4 beta-hairpin" evidence="7">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="105"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="105"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="125"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG5074121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="141" mass="16226" checksum="F786AF485276402A" modified="2022-05-25" version="1">MLPKGTVHIDLPGLARIAKKLKIDCAQAVVGFNFGCRGAMPMTQGYIVCEEHEETIRDAWTQEQVEAEKRAKEKRDKRIWGNWKKLIRGVLIKEKIAYKYNMNDSQEDKDDSLDGDFDDQDKKNKVPGKKTKSNSIKKRKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2EB78</accession>
    <name>A0A8J2EB78_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similar to UBE2G2: Ubiquitin-conjugating enzyme E2 G2 (Bos taurus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS399</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001114">
        <property type="protein sequence ID" value="CAG5073456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2EB78"/>
    <dbReference type="OrthoDB" id="19692at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UBC core" evidence="1">
        <location>
            <begin position="4"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5073456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="94" mass="10549" checksum="99E4DAD15FB984C9" modified="2022-05-25" version="1">MAGSALRRLMAEYKQLTLNPPEGIVAGPIHEENFFEWEALISGPDGTCFEGGIFPAKLIFPPDYPLSPPKMQFTCEMFHPNSKIFLNYSSSFSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2ED54</accession>
    <name>A0A8J2ED54_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Odorant receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HICCMSTLAB_LOCUS1838</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Cell membrane</location>
            <topology evidence="1 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the insect chemoreceptor superfamily. Heteromeric odorant receptor channel (TC 1.A.69) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001116">
        <property type="protein sequence ID" value="CAG5075742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2ED54"/>
    <dbReference type="OrthoDB" id="6597368at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005549">
        <property type="term" value="F:odorant binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004984">
        <property type="term" value="F:olfactory receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004117">
        <property type="entry name" value="7tm6_olfct_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21137">
        <property type="entry name" value="ODORANT RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21137:SF35">
        <property type="entry name" value="ODORANT RECEPTOR 19A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02949">
        <property type="entry name" value="7tm_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 10" id="KW-0552">Olfaction</keyword>
    <keyword evidence="8 10 11" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="9 10" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="122"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="166"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="248"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="284"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU351113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAG5075742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="373" mass="42876" checksum="0318C5FDCC94A1EA" modified="2022-05-25" version="1">MEIFDSFFLLLSLAGLWKPRGWRGIKAFCYYIYQLSVVLSEHLFIISGALDLQFKNIELEALVDNLALLLVIILCRQKMACVISNREAVKSILESLGKPPFKPRDHQEELIIQKFNRFVKKIFICYPATFIGALLLYSGSRSNIVDPPYILPYKGWFPYNYTSPTIYWMTALFQLYAVYIATAIDLVFDLLLAGIICYLRSQVGILRHRFEVMVQKLEVSADRERSLVAEWVQFHVHIVNLVKYLNKIFSSVIFVQYTSSSLILCTLAYLMAHTEVTTINFLGYFGFLAGMYLQIFLQCYCAHILTSEFLSVSRGICTTNWFNLSNDIKKSIVIIMCKCDKPVLIASGFFFVLSLDSFTKVSKLAYSIYNVLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2EDR4</accession>
    <name>A0A8J2EDR4_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS2240</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001117">
        <property type="protein sequence ID" value="CAG5076642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2EDR4"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5076642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="78" mass="9022" checksum="55D6A1D9E3F292F7" modified="2022-05-25" version="1">MTDLSSSSVFQIKEQSKNSLNGIPHQHFDDIFLATFCRQVVRRLGHWVEGDEESDWQDSTSDTIIRVRDKRTNTVSPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2EI65</accession>
    <name>A0A8J2EI65_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS311</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001114">
        <property type="protein sequence ID" value="CAG5073367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2EI65"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5073367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="69" mass="7561" checksum="0FD97450C5805061" modified="2022-05-25" version="1">MEPLLASPLPPECLLLCLGKPSLGMEMTEGCSRRRGTSLARVLSSERVTRFSMNILRPKKRASRSAAAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2GZA2</accession>
    <name>A0A8J2GZA2_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to Ppm1l: Protein phosphatase 1L (Mus musculus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS254</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001114">
        <property type="protein sequence ID" value="CAG5073270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2GZA2"/>
    <dbReference type="OrthoDB" id="343114at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043169">
        <property type="term" value="F:cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000222">
        <property type="entry name" value="PP2C_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01032">
        <property type="entry name" value="PPM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="48"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="164"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5073270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="190" mass="21665" checksum="D8CE1A1E943E62D3" modified="2022-05-25" version="1">MDDELEDKIIYQTYLSHMKLMSKIAVGGLLPAGINAPLVYFWKLMRYYALRPEIVLCGAIIFIIIYYLQAVDTWSRSLINKFHYTVYKNNSKVSKLQYLVNHANAGDKISWELEQNNVAVYAVQGHRDHMEDRFIVNSDINRTGVSVFAVFDGHGGERFSHRRLHGEQDNNRPGAAGQVGELTACNNPRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2GZS2</accession>
    <name>A0A8J2GZS2_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Similar to cnc: Segmentation protein cap'n'collar (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HICCMSTLAB_LOCUS1024</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001114">
        <property type="protein sequence ID" value="CAG5074332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2GZS2"/>
    <dbReference type="OrthoDB" id="7458135at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14698">
        <property type="entry name" value="bZIP_CNC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.880.10:FF:000004">
        <property type="entry name" value="Nuclear factor, erythroid 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.880.10">
        <property type="entry name" value="Transcription factor, Skn-1-like, DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004826">
        <property type="entry name" value="bZIP_Maf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047167">
        <property type="entry name" value="NFE2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008917">
        <property type="entry name" value="TF_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24411">
        <property type="entry name" value="NUCLEAR FACTOR ERYTHROID 2-RELATED FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24411:SF55">
        <property type="entry name" value="SEGMENTATION PROTEIN CAP'N'COLLAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03131">
        <property type="entry name" value="bZIP_Maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47454">
        <property type="entry name" value="A DNA-binding domain in eukaryotic transcription factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0010">Activator</keyword>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BZIP" evidence="7">
        <location>
            <begin position="448"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="221"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="556"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="9"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="247"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="574"/>
            <end position="586"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG5074332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="586" mass="66317" checksum="EB03F93616872B12" modified="2022-05-25" version="1">MMHTQQYHPHSHPHLHPHRHYQSRVAYGRPMGADQRWPPGELFLSLPSATDFGHPSHPGYPGHGLNSTHHYEMQRNVVLNNATLPLPVGDYNSTGPFQNIGPSNLGSAVATSMNLTNSSEPIGTDTTGPYKPEPHDINYTHYSHNPLTSEGNLNPDGLFSNILDDTNLQLMDFADDGMYGCMRNWDTSNNGTQNSTTLAPQASTAPAVTNLTGAITDERLDASSDSAVSSMGSERVPSLSDGEWMETGSNSSHTQADSHYSMDYASKYRMQYECNYTVNGRTGNRCPVDRIPPVAQKKHQMFGKRYLQDHGTGSPLGHHGHGPPIKYEYDPQAVAAGPAHAYSPLDGAAGPEMKFSCSVDFARQLHHVPGRTALEHIHHNHTYHLPPDSSGAMRPLARDKKNQHLTRDEKKARQHNVPISVHDIINLPMDEFNERMSKYDLSETQVSLIRDIRRRGKNKVAAQNCRKRKLDQIMTLADQVKEMKDRKMRLLSDRDYMLRERQRVKEKFGQLYRHVFQSLRDSEGNQYNHQEYSLQQAADGNFHLVRRNQVLQQHHNHNHNHNHNHTGPYPRQSMDPKTKPDPERKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H078</accession>
    <name>A0A8J2H078_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Similar to chmp7: Charged multivesicular body protein 7 (Xenopus laevis)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HICCMSTLAB_LOCUS1673</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001116">
        <property type="protein sequence ID" value="CAG5075519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H078"/>
    <dbReference type="OrthoDB" id="10250120at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009898">
        <property type="term" value="C:cytoplasmic side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000815">
        <property type="term" value="C:ESCRT III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005771">
        <property type="term" value="C:multivesicular body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032511">
        <property type="term" value="P:late endosome to vacuole transport via multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006900">
        <property type="term" value="P:vesicle budding from membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005024">
        <property type="entry name" value="Snf7_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22761">
        <property type="entry name" value="CHARGED MULTIVESICULAR BODY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22761:SF10">
        <property type="entry name" value="GH13992P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03357">
        <property type="entry name" value="Snf7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25880">
        <property type="entry name" value="WHD_CHMP7_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0967">Endosome</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="385"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="405"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAG5075519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="436" mass="50493" checksum="264E17E83A888989" modified="2022-05-25" version="1">MISSNSNDVTPLPTQNMPDSWFKDEQMNAMFAEFRNRSVNPQDWDSKYKFWQELISKWLSFNNKCCFTIIDLKSTFKRKGCTPLCLNTVIEELYRNREIVTENEFLQDQKTWGSWLVDTVVKKPVVWSFSKLKNYFVTNVPVNSETRYVHLKTVKGLAETILSLSSDKKPIILTVQQITEKCRIAYNNNNLSEENVKLALIWIGRLKSSQLSNRNNNAWNSLLKISPDSISNLTESEEGLYKIQESEKVILKRIEELEIERNDVLAKVKSYINRGLKDVAKTFLRRKHELDKRIEKHAMTLQNLQTLITSISDAHSNTEVLDAYKKGSEILKNCEKAGLSEINARDTMDDVREIMEEFDEMQKSLTEPIKLNESDDELEKELDDLLHSDSPDKSLPPVPSSEIPELEKRLSDLRLPEFPSPPETKSFTSQEVKDFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H2X6</accession>
    <name>A0A8J2H2X6_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS150</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030000836">
        <property type="protein sequence ID" value="CAG5072349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H2X6"/>
    <dbReference type="OrthoDB" id="7700589at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5072349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="235" mass="26902" checksum="21424DE4ACF7AC7A" modified="2022-05-25" version="1" fragment="single">SSSEWEDTSNSSNSIETVSQIVNEKNKSNNCSEREWSFDHSITNMTNSSSGSFHVETINNPANNKILHDELPEEPILDESLYSRIIKWIINNIDKLPMTTVYELLEILIKEGYKMFPPKAHVLLGYKHSINSQPVLTKNNTFGQYLYLGIVNGLEKRINPEIFKEECIKIVVFIDGMKIYKSTKGQLWHIVVQLYDKKYESSPFVAGLFYGDAKSSDVDSILNDFVNELKLLINN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H378</accession>
    <name>A0A8J2H378_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="18">Similar to KCNH8: Potassium voltage-gated channel subfamily H member 8 (Homo sapiens)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">HICCMSTLAB_LOCUS665</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>K(+)(in) = K(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29463"/>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001114">
        <property type="protein sequence ID" value="CAG5073893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H378"/>
    <dbReference type="OrthoDB" id="447251at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034702">
        <property type="term" value="C:monoatomic ion channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005249">
        <property type="term" value="F:voltage-gated potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042391">
        <property type="term" value="P:regulation of membrane potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000145">
        <property type="entry name" value="Eag-like K[+] channel, isoform B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.10:FF:000097">
        <property type="entry name" value="Eag-like K[+] channel, isoform B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1200.260:FF:000002">
        <property type="entry name" value="Potassium voltage-gated channel subfamily H member 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003938">
        <property type="entry name" value="K_chnl_volt-dep_EAG/ELK/ERG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003967">
        <property type="entry name" value="K_chnl_volt-dep_ERG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050818">
        <property type="entry name" value="KCNH_animal-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10217:SF637">
        <property type="entry name" value="EAG-LIKE K[+] CHANNEL, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10217">
        <property type="entry name" value="VOLTAGE AND LIGAND GATED POTASSIUM CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01463">
        <property type="entry name" value="EAGCHANLFMLY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01470">
        <property type="entry name" value="ERGCHANNEL"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="cAMP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="13" id="KW-0407">Ion channel</keyword>
    <keyword evidence="10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0630">Potassium</keyword>
    <keyword evidence="6" id="KW-0631">Potassium channel</keyword>
    <keyword evidence="4" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <keyword evidence="7" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="93"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="224"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="312"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="17">
        <location>
            <begin position="434"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="558"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="704"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="761"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="813"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="847"/>
            <end position="905"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="576"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="719"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="815"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="869"/>
            <end position="884"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00034430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="CAG5073893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="924" mass="103869" checksum="B8198BA30156F778" modified="2022-05-25" version="1">MADNDPKDSNNAQSTHLNGDIDPEAPSPNYGGRRRSRGILYTLSGHYNQDGKHKLHNKPLLHSPSATPLPEYKTSAAEKSSFTVRHYGSFRTTWEWITLVATIYVAVVVPYNASFVSTERSTVVSDVIVEAIFIVDILLNFRTTYVSKKGNVVLSGGKIAINYLKRWFLIDLLAALPFDLLYAFDVYSGEESGHSHIHLVKLTRLLRLARLFQKMERYSQYSGVILALLMLAFSVVAHWLACIWYVIAESEGRHNDKEWNLSWLHSLADRLKIPVQNVTRTESYVTALYFTCSSLTSVGFGNVSANTTYEKIFSIIAMLIGALMHAVVFGNMTAIIQRVYSRRSLYRTKWRNLKDFLTLHQIPDQLKQRMQDYFQTTWSLNHGIDIHETLREFPEELRGDVSMHLHREILSLPIFEAASLGCRKLLSLHIKSNFCAPEEYLVRRGDALSYIYYLTNGSMEVEQNKMVVAILGKGDLVGCDIDVHLQHGTNGGGGGSGGAVDVIVKSSCDVKALTYCYLKCIHIQGLIDVLRLYPEYQHQFAREIIHDLTHNLREGYEVEQESDMNGVPSLTLPSISEDDENVQEDGETSPLSPANRSPMHITSPRHKFRSDRVGRLVRGGLRNRVQVVTQESLEDHNRDANERLEATQVSTMHEDVITLSDELRNAIKALQLMVRTPRSNPSLPTPTGHSSCEDRLLAKSSSYLPDELSWGPPTRLMDASTQTDDNYSAPNLQSHEEWVKNNPQKVLVILGLDPELIGTSQGVSEQEYHHSTNSSPSSLPPPPYEPLPLFHSGSTPQLQECSRFQTGDKLDYTLSEKNSSSSSSSVSQRSAPSQAYRAINEIPHRFSAGDVESRARHRTMQPKNTDIISKSDSDATDGDIHKDSTLITQDPKKRTRKRSTKACELELSSQRSRLKLISDIEAVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H3M6</accession>
    <name>A0A8J2H3M6_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similar to Tdpoz5: TD and POZ domain-containing protein 5 (Mus musculus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS1372</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001116">
        <property type="protein sequence ID" value="CAG5075218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H3M6"/>
    <dbReference type="OrthoDB" id="7628309at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.210.10">
        <property type="entry name" value="Apoptosis, Tumor Necrosis Factor Receptor Associated Protein 2, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008974">
        <property type="entry name" value="TRAF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24413">
        <property type="entry name" value="SPECKLE-TYPE POZ PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49599">
        <property type="entry name" value="TRAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="187"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5075218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="350" mass="40608" checksum="CAC45A975C6F34A4" modified="2022-05-25" version="1">MQNLKVTQHYNLVEKQKLIYQWKIMDFFSLIDLYSYAKDPDTLNLNFRDPVENSKDHRIRILKLGFNGRESVNQGWISITLSPNIKYYADTKYSLYILDNVNKKHFIQTFDKIIIKKPDELRIPRLVEISKLLEMKDKFLPNNHLTIGVEVTGFIRTNSDRIESQFKTPRNQIIRELKDIFESKAGSDVVLLVGDKKTKILAHKLILTTCSPVFAAEFSYQLKIKGGNEITLPDMDPEVCEKLLEYIYTENVTGLDEIAERLYEQAVKHQLTTLKKLCEDSFCRGVTVENAVKYLVLLDRHHADKKFFDNVLRFIALNSKTVIKTPEFKELEKINPGLLTTIVTMIASVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H436</accession>
    <name>A0A8J2H436_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">WD repeat-containing protein 44</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HICCMSTLAB_LOCUS2056</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001116">
        <property type="protein sequence ID" value="CAG5076075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H436"/>
    <dbReference type="OrthoDB" id="1932312at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000060">
        <property type="entry name" value="WD repeat-containing protein 44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040324">
        <property type="entry name" value="WDR44/Dgr2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14221">
        <property type="entry name" value="WD REPEAT DOMAIN 44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14221:SF0">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 4" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="532"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="627"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="667"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="817"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="178"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="422"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="65"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00021207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAG5076075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="952" mass="105981" checksum="BD49A506328FB637" modified="2022-05-25" version="1">MSGSSDSEEFFDAEDDSFNRSRKSNGRESLPPVSQVPPEKPGPTLTDDSVFVKPLDPKPPTAPADESKPVSKPDDEEKTLDKLKGRRRFRELRQRMQTEDDDIPISNSPPDSQTSSIEGVYPAPAKTTHPFRIIEHDTVSLQSMTSLGRVGRILAGAGDSLSGVLHHGVSCPIPLTRDMQMSSIPSRDEDTGSEKASQSSSVITLSGDIVQDSASVNGRKEFANLNCQANNVGLQEPDVIASTKGNGKTLDRDQAPHSLDIRSAIKGQYVVKPQASFSSNIVLYLRNDKIPARLESFETLRGFYSHRYRDEDKSKAEGPSAEEIERLEKMKAELISLQSSDKSSSPLGSLSSNSVGRYSLGQHRLATSLQGTRERRKSAGDQDMVKQLNMFRVPLSIAEDKLPQCMNPLSLHIMRLTSEYVSNSSLDKEKESDEESVDSKMSSIPPDEDVTVGRVRKKTQKIKRFLGSTVRKTMDKAKSIAQEVSHARHKEDVMDIVDDVYPGEPQCIKLKASNSHKGPYEFSNLQHVQDLSGEHVGPVWCMKFSACGRLLATAGQDRVLRIWVLRDAFTYFQDMRTKYNAEKVSPTPSQESLVSQQSMEDPNIIASAMSEVEGTKSPFMPKPFCTYTGHTSDLLDVSWSKNYFVLSSSMDKTVRLWHISRKECLCCFQHIDFVTAIVFHPRDDRYFLSGSLDGKLRLWNIPDKKVAVWNEVNGSTKLITAANFCQNGKFAVVGSYDGRCIFYNTDQLKYHTQIDVRSTRGKNARGRKISGIEPMPGEDKILVTSNDSRIRLYDLRDLNLSCKYKGYVNVSSQIKASFSPDGQYILAGSENQCIYIWKTHHDYSKFSSVRRDRNDFWEGIKAHNAVVTCAVFAPNPDSIIKQIEAREKWDNPDSTSSNSSANPKPVVDPVVEQRTKGCGGHVLVSADFNGCIKVFLNKTKPKHSSLPASALA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H5C3</accession>
    <name>A0A8J2H5C3_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS346</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001114">
        <property type="protein sequence ID" value="CAG5073403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H5C3"/>
    <dbReference type="OrthoDB" id="7700848at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5073403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="136" mass="15424" checksum="15D9D5740302A2EE" modified="2022-05-25" version="1">MNNRNEIQRVKQSTRARTIAIRIDTQKLTSTRTFDTPLPVAGSAQTGCLSSSSSDCWEREAGWTPPRRSKRLGQQKNAKHKAAKKRLVTQIKASKGKCWKVICREVDDDLWGNDYLIITLKFVGLGLVAYMEPDRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H5I8</accession>
    <name>A0A8J2H5I8_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Similar to PPAF2: Phenoloxidase-activating factor 2 (Holotrichia diomphalia)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HICCMSTLAB_LOCUS890</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase S1 family. CLIP subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001114">
        <property type="protein sequence ID" value="CAG5074118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H5I8"/>
    <dbReference type="OrthoDB" id="6261922at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051487">
        <property type="entry name" value="Ser/Thr_Proteases_Immune/Dev"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24256">
        <property type="entry name" value="TRYPTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035151905" evidence="3">
        <location>
            <begin position="21"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="4">
        <location>
            <begin position="93"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00024195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAG5074118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="333" mass="36645" checksum="086317738B7AD794" modified="2022-05-25" version="1">MASIAWIIFGTILIINSATSIVQNFGSNRKCHCGYVENFCSANLQLFNYLNNHNCYSYSPAYCPDNKVRYCSIPDGSISETCGMKKMTVMTKKINGQSQVGEHPWQAAILTSNGDGNYKYKGAGALIHKKHVITVVQNVETGDVIRLGEWDLLSNQEICSQQDYQAKKIIKHPGFNTDTMENNIALIILDRNVPLATSPHISTACLSSSTPSFGSRCWIAGWGGCQQLTPGTTKRLRDVNIPIVNRWACQQSIQNFLTETYELPESIFCAGEGKMDSCMIDGGAPLVCESASGRMEVVGLVSASVGCQQNVPSLFTDVSKFTSWIHKQVFEHC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H698</accession>
    <name>A0A8J2H698_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">thioredoxin-dependent peroxiredoxin</fullName>
            <ecNumber evidence="2">1.11.1.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HICCMSTLAB_LOCUS2695</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>a hydroperoxide + [thioredoxin]-dithiol = an alcohol + [thioredoxin]-disulfide + H2O</text>
            <dbReference type="Rhea" id="RHEA:62620"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:35924"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="EC" id="1.11.1.24"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peroxiredoxin family. AhpC/Prx1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.24" evidence="2"/>
    <dbReference type="EMBL" id="CAJNRD030001117">
        <property type="protein sequence ID" value="CAG5078271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H698"/>
    <dbReference type="OrthoDB" id="185659at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008379">
        <property type="term" value="F:thioredoxin peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033554">
        <property type="term" value="P:cellular response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008340">
        <property type="term" value="P:determination of adult lifespan"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03015">
        <property type="entry name" value="PRX_Typ2cys"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000003">
        <property type="entry name" value="Peroxiredoxin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050217">
        <property type="entry name" value="Peroxiredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019479">
        <property type="entry name" value="Peroxiredoxin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10681">
        <property type="entry name" value="THIOREDOXIN PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10681:SF128">
        <property type="entry name" value="THIOREDOXIN-DEPENDENT PEROXIDE REDUCTASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10417">
        <property type="entry name" value="1-cysPrx_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="7" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="10">
        <location>
            <begin position="49"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="219"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="229"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAG5078271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="241" mass="26978" checksum="E0DD3E8F6D1384D8" modified="2022-05-25" version="1">MSRLLINLCPKIKTLVSSAAGSLIDVKSVNFINSTRNFSITSRLLSAWPQIQKRAPEFTGTAVVDGDFKEIKLSDYSGKYLVLFFYPLDFTFVCPTELIAFNEKLSEFKSLNTEVVGVSTDSHFSHLAWINTPRKQGGLGGLGYPLLSDFNKQISSRYGVLLDEPGVALRGLFIIDKEGFLRQMSVNDLPVGRSVDETLRLIKAFQFVEKHGEVCPANWQPDSKTIKPNPKDSKEYFETVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H6M8</accession>
    <name>A0A8J2H6M8_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS2949</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001117">
        <property type="protein sequence ID" value="CAG5079186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H6M8"/>
    <dbReference type="OrthoDB" id="7697800at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5079186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="187" mass="21749" checksum="ECBF20BBDF6FF47E" modified="2022-05-25" version="1">MFKYKILKKTVCECAAEIIDEVQEIWSDMNTPLIKHQHAIKKMEMLFTEWRNLDKSRLKKHSEFHLLKIKKFTDKLNELFDVRLKKDISHDSCPEKLFSLVRRSKGRLTPIPDDVEDESFPLEPIENDIDENVLSQALSDTSISFEELSRSSSNDPAPIMRGTEILLLFLRHVRIIAAIAVFIHISS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H6N4</accession>
    <name>A0A8J2H6N4_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS2891</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001117">
        <property type="protein sequence ID" value="CAG5078965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H6N4"/>
    <dbReference type="OrthoDB" id="7613723at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035275132" description="Ig-like domain-containing protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="2">
        <location>
            <begin position="66"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5078965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="271" mass="30474" checksum="61FEC3D7A17EF3E1" modified="2022-05-25" version="1">MLCFDLANFGILMVLVTSEVEPKETIKPVNLDDSQPKTRVEGPRFKIANGDYNATSNELMKPTNEPDDVDSFSLGTVNREIIINEGITITMQCSASIDRFPDDIKWYNTSNLLATDGRVVIKETKETPLHSSHLTIGDIQKWDKGDYTCERTTKNVCLSELTITPIGQIVINEGDLLAITCTASEDVDFFYPQFISFLVDTSPSLITNEPANGGSKFIFKRPKAVYGDTGYYGCVEASKNKRKLNLRNIYVTPETYDEIDIKWTYVYVKCN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H6S7</accession>
    <name>A0A8J2H6S7_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS2905</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001117">
        <property type="protein sequence ID" value="CAG5079022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H6S7"/>
    <dbReference type="OrthoDB" id="7672739at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035308749" evidence="1">
        <location>
            <begin position="21"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5079022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="277" mass="31878" checksum="0987DD93EF770574" modified="2022-05-25" version="1">MFKYFILILNILGLILTAEAQVYQNNLKVSTRLDLSGSLKHLCGEDDQNDNDQVVSCDCLSKLSVVSTVQHYKESNQNGVNTYALLHETEENLEVYGSGRFNFHNVKCVENNEVKNVKSRYTYWFHVYFTYSVVPIPNKVLDYVDYEDEDLLPVTIVNITLENAPKFKYLKLKLDDSEIYNFEDNLGTMCGESLEKGFMEHTLWSIIDQVLLHNDNNCNYPKGSTFPIVEKMPMTVTVDEPLKSGMYTLAFSFFLEGESVTLDWYGKTFWYLEAGST</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H6V8</accession>
    <name>A0A8J2H6V8_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Similar to Early 94 kDa protein (Autographa californica nuclear polyhedrosis virus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS2997</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001117">
        <property type="protein sequence ID" value="CAG5079383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H6V8"/>
    <dbReference type="OrthoDB" id="8120898at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5079383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="229" mass="27378" checksum="D4D8F9A3B4AF9401" modified="2022-05-25" version="1">MLDKIFKNINGFLVCEIEKPVNLQKLNYLKLNHKGMLHTDIIQEKVHLNEYVHLINYEDDSNKNGKIIVKICEKTFRPFFTIDQETSFYSELVKITKKVIINNDDDKNNVKISYDTIDSLEFDKILSLYNLFLRCAKDSKKYPTLPEYLEYVSRKKKFNRDLVTIFPPDVYASLEDVHSRYQNVMETVDVNKLIEVFKRYAKRLERIKEEVVLKFNNDHAFNEFITWEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H6X7</accession>
    <name>A0A8J2H6X7_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Similar to Nup54: Probable nucleoporin Nup54 (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">HICCMSTLAB_LOCUS2811</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the NUP54 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001117">
        <property type="protein sequence ID" value="CAG5078684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H6X7"/>
    <dbReference type="OrthoDB" id="6162375at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044613">
        <property type="term" value="C:nuclear pore central transport channel"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006607">
        <property type="term" value="P:NLS-bearing protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006999">
        <property type="term" value="P:nuclear pore organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036228">
        <property type="term" value="P:protein localization to nuclear inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.490:FF:000003">
        <property type="entry name" value="nucleoporin p54 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.490">
        <property type="entry name" value="Single helix bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024864">
        <property type="entry name" value="Nup54/Nup57/Nup44"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025712">
        <property type="entry name" value="Nup54_alpha-helical_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040985">
        <property type="entry name" value="Nup54_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13000">
        <property type="entry name" value="NUCLEOPORIN P54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13000:SF0">
        <property type="entry name" value="NUCLEOPORIN P54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13874">
        <property type="entry name" value="Nup54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18437">
        <property type="entry name" value="Nup54_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="7" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0811">Translocation</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Nucleoporin Nup54 alpha-helical" evidence="12">
        <location>
            <begin position="390"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="domain" description="Nup54 C-terminal interacting" evidence="13">
        <location>
            <begin position="542"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="441"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="14"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="24"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00060798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF13874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF18437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CAG5078684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="593" mass="63680" checksum="B18A7679685792BE" modified="2022-05-25" version="1">MSFGTSFGAAAPASQPSFNFGSQTTTATPVKPTTTSQSLFGTPGSNFGSAAPTFGTPSTNFGTSTSGTTNTFTSTGSTFGFGTQNSTSFGAPVSSSFGTTSTFGSGVPTFGSAPSSSSFGFGNFGSNPPTTSSSLFGAFPSTSAPAFGSTFSSFAKPATTFAGFGTPGFGATTTTQSGFGTGTGLSFGTGTGTLGFGQQPAPQASASEALYNAVFNCQLFNDERDNTIARWNLIQALWGTGKAFYAADKPPLELNQENLLCRFKAIGYSCMPVTENNDGLVGLCFNKKEQELKDSKQQLVTSLSAILGNKPNLTVTVDNVKGTGENKTQVTIYVTEKGVTGSVRKIPANELVGFLSQPMQKQQLTNMGIDNMFAQVKLDAAALKEYLDNPPSSIDPRLWKQAQLDNPNPESYIPVPMIGFQQVKHRLKCQEEETARHRAFLDLVAEEIQELQRAHTATQARLKEHRRSLLELQHRVLQVLVKQEITRKVGLSLQPEEEVLTKRFEAMYAQISAPTQFKGRISEMLSQLRMRRHVDLQGQERYSMDPIAQDDIKAYLSLEQQGMAQLIDTITTDLESLKVIKDGMADLLTGNTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H7L4</accession>
    <name>A0A8J2H7L4_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Similar to dpp: Protein decapentaplegic (Tribolium castaneum)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HICCMSTLAB_LOCUS3379</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the TGF-beta family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5081790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H7L4"/>
    <dbReference type="OrthoDB" id="5987191at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005125">
        <property type="term" value="F:cytokine activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008083">
        <property type="term" value="F:growth factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051094">
        <property type="term" value="P:positive regulation of developmental process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051240">
        <property type="term" value="P:positive regulation of multicellular organismal process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd13760">
        <property type="entry name" value="TGF_beta_BMP2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.90.10:FF:000103">
        <property type="entry name" value="Bone morphogenetic protein 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.90.10">
        <property type="entry name" value="Cystine-knot cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029034">
        <property type="entry name" value="Cystine-knot_cytokine"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001839">
        <property type="entry name" value="TGF-b_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001111">
        <property type="entry name" value="TGF-b_propeptide"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015615">
        <property type="entry name" value="TGF-beta-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017948">
        <property type="entry name" value="TGFb_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11848:SF263">
        <property type="entry name" value="PROTEIN DECAPENTAPLEGIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11848">
        <property type="entry name" value="TGF-BETA FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00019">
        <property type="entry name" value="TGF_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00688">
        <property type="entry name" value="TGFb_propeptide"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00204">
        <property type="entry name" value="TGFB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57501">
        <property type="entry name" value="Cystine-knot cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00250">
        <property type="entry name" value="TGF_BETA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51362">
        <property type="entry name" value="TGF_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="6" id="KW-0221">Differentiation</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 10" id="KW-0339">Growth factor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="domain" description="TGF-beta family profile" evidence="11">
        <location>
            <begin position="298"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAG5081790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="417" mass="46379" checksum="A624DAECEC7444E0" modified="2022-05-25" version="1">MPHPGVAVPVTGVTMRTLLLLRLVFVGVGVLVTDISTATTLQTDNNIAQASSNYIESSSDSVDDMDPNDKQRITASVEASLLSLLGFSKRPRPKGKPHVPESLKKLYTKQNSISSSNIAKKGLHTRSANTVRSFSHIESPLDEKFQSSNRFRLSFDLSSIPQEEILKAAELSLTRIALESGSKKLARILVHDIIRPGVKGQHKPLLRLIDSRVIDMTSNSTISLDVHPAVSRWLQDGNNHGLLIQVSSRNRTSDSHVRLKRSVDESHDTWSSSRPTLFTYTDDGRSKMASASEIMDRRARRAALRKNRRKDGRENCRRHPLYVDFVDVGWNDWIVAPPGYDAFYCNGDCPFPLSDHLNSTNHAIVQNLVYSTNPAMLPRACCVPTALSSISMLYLDEENKVVLKNYQDMAVIGCGCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H7R5</accession>
    <name>A0A8J2H7R5_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ubiquitin-related modifier 1 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HICCMSTLAB_LOCUS3483</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Acts as a sulfur carrier required for 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Serves as sulfur donor in tRNA 2-thiolation reaction by being thiocarboxylated (-COSH) at its C-terminus by the MOCS3/UBA4 homolog. The sulfur is then transferred to tRNA to form 2-thiolation of mcm(5)S(2)U. Also acts as a ubiquitin-like protein (UBL) that is covalently conjugated via an isopeptide bond to lysine residues of target proteins. The thiocarboxylated form serves as substrate for conjugation and oxidative stress specifically induces the formation of UBL-protein conjugates.</text>
    </comment>
    <comment type="pathway">
        <text evidence="6 7">tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6 7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="6">C-terminal thiocarboxylation occurs in 2 steps, it is first acyl-adenylated (-COAMP) via the hesA/moeB/thiF part of the MOCS3/UBA4 homolog, then thiocarboxylated (-COSH) via the rhodanese domain of the MOCS3/UBA4 homolog.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6 7">Belongs to the URM1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5082194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H7R5"/>
    <dbReference type="OrthoDB" id="10248987at2759"/>
    <dbReference type="UniPathway" id="UPA00988"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032447">
        <property type="term" value="P:protein urmylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034227">
        <property type="term" value="P:tRNA thio-modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002098">
        <property type="term" value="P:tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01764">
        <property type="entry name" value="Ubl_Urm1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.30:FF:000021">
        <property type="entry name" value="Ubiquitin-related modifier 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03048">
        <property type="entry name" value="Urm1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016155">
        <property type="entry name" value="Mopterin_synth/thiamin_S_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015221">
        <property type="entry name" value="Urm1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14986">
        <property type="entry name" value="RURM1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09138">
        <property type="entry name" value="Urm1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037379">
        <property type="entry name" value="Ubiquitin-related_modifier_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54285">
        <property type="entry name" value="MoaD/ThiS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 6" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6 7" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="5 6" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="modified residue" description="1-thioglycine" evidence="6">
        <location>
            <position position="103"/>
        </location>
    </feature>
    <feature type="cross-link" description="Glycyl lysine isopeptide (Gly-Lys) (interchain with K-? in acceptor proteins)" evidence="6">
        <location>
            <position position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG5082194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="103" mass="11638" checksum="0A2B06D222902CFF" modified="2022-05-25" version="1">MSSESAELPITIEFGGGAELLFGNKKKHQINLPANKNWTLKDLIFWIRDNLLKEREELFLQNDTVRPGILVLVNDSDWELLGQGEYNLSPNDTVLFISTLHGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H7W7</accession>
    <name>A0A8J2H7W7_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Similar to rpusd1: RNA pseudouridylate synthase domain-containing protein 1 (Danio rerio)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HICCMSTLAB_LOCUS3788</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the pseudouridine synthase RluA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5083274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H7W7"/>
    <dbReference type="OrthoDB" id="418349at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009982">
        <property type="term" value="F:pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000455">
        <property type="term" value="P:enzyme-directed rRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02869">
        <property type="entry name" value="PseudoU_synth_RluA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2350.10">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006145">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050188">
        <property type="entry name" value="RluA_PseudoU_synthase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21600">
        <property type="entry name" value="MITOCHONDRIAL RNA PSEUDOURIDINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21600:SF87">
        <property type="entry name" value="RNA PSEUDOURIDYLATE SYNTHASE DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00849">
        <property type="entry name" value="PseudoU_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="domain" description="Pseudouridine synthase RsuA/RluA-like" evidence="3">
        <location>
            <begin position="52"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG5083274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="259" mass="30257" checksum="F5B145648433642B" modified="2022-05-25" version="1" fragment="single">SLNKVNKLFIVIVMTVWLWFINKMIIIFNFIKNLLFFNNKLTKSNILYHSNNYLIINKPYDMVVNSNDVTVKKTLENELKKMFPSLANPSLKNGFHFVHRLDYPTSGVICIALNKNAARQDTREIFGNKKMCTSDDDHCIKPRDSSTLLLVLEKGFCDGKPATKILLRPNTGRRHQLRVHCCYIGHTIIGDYTYSDRKDLKPHRTFLHSFRLALDSEVEKFDVQTSDPFNSEYYFNKWVPINFIYTLDSNTFDTIDKLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H806</accession>
    <name>A0A8J2H806_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HICCMSTLAB_LOCUS3845</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5083461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H806"/>
    <dbReference type="OrthoDB" id="7697859at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00397">
        <property type="entry name" value="DNA_BRE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="entry name" value="Intergrase catalytic core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050090">
        <property type="entry name" value="Tyrosine_recombinase_XerCD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30349:SF41">
        <property type="entry name" value="INTEGRASE_RECOMBINASE PROTEIN MJ0367-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30349">
        <property type="entry name" value="PHAGE INTEGRASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="DNA breaking-rejoining enzymes"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="274"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="437"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="504"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="437"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="457"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="477"/>
            <end position="486"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG5083461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="764" mass="84967" checksum="BD3570CC25834562" modified="2022-05-25" version="1">MELSDSENSDNEPMTPPELSKETEESAEAVEVDPGQHTIPEYSREKYFRAYEVFKEWQLKHDHDEVTEAVMLEFFEELNETKKPSTLWSQYSMLKSTFNLKEDLDISQFKKLRAYLKKQGTGFKNAKSKVLSAANIHDFLIKASDYEFLAEKVIMIFGVVGACRKSEIVDLTLSDLIDSGTSLVVTIQATPRRQMRKFTIDGDLYNASNILKTCMSDIQQPQSHPSTQIIINQIPINQQVGGRQFQVNQGQIITTPKRLYTSVGQIINNAGQLNNSQGQQVDNSGQVDGNSSQAHLDDNQQVDSGQKSTGQLHRVQVILILGFCGAMRCKELCNLNYNDIEDVGSKFIVSVPDAKNVYPRSFVIMNQFYNIVKKYVALRPDKCAHERFLLCYRSGYCIRQPIGKNKISNVPQNIAKFLNLPNPPAYTGHCFRRTSTSLLGNSGASHSNHPPAKRPRTSGGSSNQNQPSSQPSASTSKSDHQLKTNEDSISSPIHNIEEFDNLDFDSPFESVSNNHSTAESTKRKKESTKETRKTLNLDGFKFVVVEIDRRIEVVQKGWSPPEGAEYVKPHAIFDSYKSASDYADTINAKKTPRVASSVAPSPKVISIDADSSNCPEPNTQEVRKVVKSGLPTRTINVVKNRVAATSTPGGSTPKRIIGTLVKKNDNQRIQLTSANGLQTIVNNKRFIGTLVNQNFTQNSIASNKQNLNSQNAKSSNVFIVVEKFDNSSNFITGDVSGNANPPMQVDTKDPTLTSTMSGINDFYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H8B1</accession>
    <name>A0A8J2H8B1_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Protein arginine N-methyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">HICCMSTLAB_LOCUS3524</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7 18">
            <text>L-arginyl-[protein] + 2 S-adenosyl-L-methionine = N(omega),N(omega)'-dimethyl-L-arginyl-[protein] + 2 S-adenosyl-L-homocysteine + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:48108"/>
            <dbReference type="Rhea" id="RHEA-COMP:10532"/>
            <dbReference type="Rhea" id="RHEA-COMP:11992"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29965"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:88221"/>
            <dbReference type="EC" id="2.1.1.320"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the class I-like SAM-binding methyltransferase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5082315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H8B1"/>
    <dbReference type="OrthoDB" id="1368803at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044020">
        <property type="term" value="F:histone H4R3 methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035243">
        <property type="term" value="F:protein-arginine omega-N symmetric methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Protein arginine N-methyltransferase 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.150:FF:000008">
        <property type="entry name" value="Protein arginine N-methyltransferase 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000029">
        <property type="entry name" value="Protein arginine N-methyltransferase 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.150">
        <property type="entry name" value="Divalent-metal-dependent TIM barrel enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.160.11">
        <property type="entry name" value="Hnrnp arginine n-methyltransferase1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025799">
        <property type="entry name" value="Arg_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007857">
        <property type="entry name" value="Arg_MeTrfase_PRMT5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035075">
        <property type="entry name" value="PRMT5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035248">
        <property type="entry name" value="PRMT5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035247">
        <property type="entry name" value="PRMT5_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10738">
        <property type="entry name" value="PROTEIN ARGININE N-METHYLTRANSFERASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10738:SF0">
        <property type="entry name" value="PROTEIN ARGININE N-METHYLTRANSFERASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05185">
        <property type="entry name" value="PRMT5"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51678">
        <property type="entry name" value="SAM_MT_PRMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="1 8 12" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8 10" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2 8 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PRMT5 TIM barrel" evidence="14">
        <location>
            <begin position="30"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="PRMT5 arginine-N-methyltransferase" evidence="13">
        <location>
            <begin position="285"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="domain" description="PRMT5 oligomerisation" evidence="15">
        <location>
            <begin position="452"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="9">
        <location>
            <position position="420"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="9">
        <location>
            <position position="429"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="310"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="319"/>
            <end position="320"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="377"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="404"/>
            <end position="405"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="site" description="Critical for specifying symmetric addition of methyl groups" evidence="11">
        <location>
            <position position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
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            <dbReference type="ARBA" id="ARBA00022679"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00023015"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00048612"/>
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    </evidence>
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    </evidence>
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    </evidence>
    <evidence type="ECO:0000256" key="10">
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    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF17285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF17286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CAG5082315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="622" mass="70816" checksum="B1CED78E84551071" modified="2022-05-25" version="1">MSGTRTVSCGLNFAAAPDLHSCLETAQQSGYEYICVPLVHPQLKREFISGPAKNRHEAFTRADMVLNSSDWNALIVGKLSPYINVDSPVRHVRENSEAMLAQELSLASHLSIPAITFKLQGGIDKNVNLACIINDKVVTVSNTQIWVQIPMENPLKQKMSYRTDEEVVCESPWEWWNEFRFICDFDKKIGVALIVSHDLPEEDEINRWLGEPIKCLILPTTLFMTNKKGYPVLGRAHQALIQRFSPLNVQFLLTGANRYSDLALYFNYLDHVWKKGFQVHGPLQRYGRGYEDYLQFPLQPLMDNLESGTYEVFEKDPVKYSEYQRAIHRAITAKIQNESLDTTLVIMVVGAGRGPLVRATLHAADMAKVNVRVYAVEKNPNAILTLHALKNDVFGPRVTIVSSDMRQWEAPEKADIIVSELLGSFGDNELSPECLDGAQKFLKDDGVSIPQSYTSYIGPVQSSKIYNELKQCHDKDKHPLAHFETPYVVYLHNKYQIDKEQPLFTFNHPNKDEVINNSRYEKKIFTAEQNSVLHGFVGYFDVVLYESITLSIVPDTHSPGMLSWFPIFFPVKEPIPVKAKEKIEISFWRKCSSRNVWYEWCITKPKCLGIHNPNGRSNTIGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H8D1</accession>
    <name>A0A8J2H8D1_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Similar to Brd4: Bromodomain-containing protein 4 (Mus musculus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HICCMSTLAB_LOCUS3539</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5082358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="303107at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090537">
        <property type="term" value="C:CERF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05509">
        <property type="entry name" value="Bromo_gcn5_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22541">
        <property type="entry name" value="SP5_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029614">
        <property type="entry name" value="CECR2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47092">
        <property type="entry name" value="CAT EYE SYNDROME CRITICAL REGION PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47092:SF1">
        <property type="entry name" value="CHROMATIN REMODELING REGULATOR CECR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00503">
        <property type="entry name" value="BROMODOMAIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00297">
        <property type="entry name" value="BROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bromo" evidence="4">
        <location>
            <begin position="111"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="200"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="660"/>
            <end position="784"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="803"/>
            <end position="1392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1439"/>
            <end position="1471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1554"/>
            <end position="1574"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1667"/>
            <end position="1695"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1798"/>
            <end position="1857"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="31"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="235"/>
            <end position="259"/>
        </location>
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            <begin position="263"/>
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        <location>
            <begin position="520"/>
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        <location>
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            <begin position="604"/>
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        <location>
            <begin position="676"/>
            <end position="689"/>
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        <location>
            <begin position="750"/>
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        <location>
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        <location>
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        <location>
            <begin position="911"/>
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        <location>
            <begin position="934"/>
            <end position="943"/>
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        <location>
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        <location>
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            <end position="1048"/>
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            <begin position="1821"/>
            <end position="1838"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAG5082358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="1896" mass="209709" checksum="34CAE02E29A5C168" modified="2022-05-25" version="1">MVRAKVKNKVGKSTKKSGQSSKAGDSEDEAPPPLVAPPPPQKKGRQTNNSLASAVGQIIIQTGDEVDKVANKKGVGRHGVSSYVAPGYPYTFGIEEEERRVGMYKVLESIKDHDDAWPFTDPVEEEYAPRYYSVVRKPMDLKTMEDKLENGEYKTIHQFKRDFSLIVENCRQYNGSENEYTEMAINLKEAFNNAIERFLESEPSSDECPPKSPPVSVSAYPLRTNTPAAAALSNSRKRYKKSNKKSKSNKTDKKTRKSRNRNDDDDDDDDECDYDFYDEDDAGEEERVLDAKSSRDKRAKKRSKSMKEREETEDDDEDGAISENTVIKSKRKKYEVSKLLPKNKRLSAKDEDKDVKEDTLKKNSTGTGNKKGQKDASIKNSKDHKENRSKKKDNFEEYHEPLDNVKSKSKRIEKKSNEKSTVQRNDKIKKSKQKKQVEELEDDRFSDIEENGKQLTTEKKKNSNSGSSNNNNSNKDKIDQRIRRSDNDKSEDKSPARVKDKKSKKKNDEQTKNGKVNNDCGKDRKKEASEVSSVKFESSLSDKDLESLDSLKDRISERSRRDEKLKLEREKLKKTSKSSTFDGFHKKNVPSNGNTFHDSDKVNNKRTKVKKSGKDKKIDEKNQQVDVKSSGKVNKSKGSRVESPAIQALNQATAQTLNDINKWLDDAPPVEEFNSKAESPTLQPSTSEPTRVPSAPVSGPKISDLARKRPATMKLFGTHGPPKPKKIQRTIDRLQPGKSKGNLLLKKPIGSNNSGSDVTNNQSNSDTNQPKRENSDEPKLSLGSVLKNADSIQLICKSLVSSPTANLSNEDDDEDRPTLLSSTAALKEDKSKESMQEAVTPKTQVEAVNDTKESEESQKPKSATPNLSAWFKAFGAPKSKKKEEEIEEVVVPKKEEVPEVALPHRQRRHSAGGSSVSESVSSFSQESPPGLSVRSPQTQSAITTPGIEQPVRAGFYQDALSTGSSPYNSPYYTTPPRYSAQLPPTPSPQNHPLSPAYPSSAAYEQNPLYPQASHQVYQKPASNENPTENFNFYPQNSPQNDAYQQQLSNSPKPSPVYPQPSPQSVPVVYQNSPQTTPPNYSQHSPQQPPTPNYSQPSPQPPAANYSQPSPQQPTPPSYSQPSPQQQQQHSPYSHQTSPQPPTNYSQPSPSQQSNSSYSVPSPKPPPPSYSQVSPQPPSYSQTSPQPIANYSQPSPQSHNFSQPSPQPPKSYTQHSPQPPPAYSQPSPQSLNYSQPSPQTPPSYSQPSPQTPPNYSQPSPQAPPSYSQPSPQAPPNYSQPSPNYSQLSPQQPSTTPVPTTYSAQSSPQPPRNYSQPSSQVSPCLQPALRQSQPNYPQQSPRQTAPTQIYAQSEKTTEEYQSSAPPSYPQGIKSNHLSYTNSGVTAPGIPEPDRRVSEYYKSEDKLQSDPPLGLNSNHQVFHQTNQFSQLYSNNFPINERVSCPPTAVDSQRSTTRISTPQDPQQQPQTQERTYENTETLKYTQQRQDQQLLAFQQNLPGHETIYQSTAGFQATPYSMPNPACRPVYSSSHYYDTSSKTSGPVTSVASTLPPVKKRMYNEPTGDSARNCIPQESRSGQEQYGYDQMISLGTSEASIVSGQYDGTYGLADSVAGNPAYARLSLGLVGRSTKDQQQLLSIPRPSSKDSLVYSRTSGSEYDLNLLQSMQSTKGMTVASMQRRETAPVSAPAPKAKKGRKKATAAAAAAAAAAAAAAAAAQQQSTTLPNHSSTIPGFPQYPGNPADIVGLKNSPVPPGSAFNFTAPVSDANNASFYDKEASSAAAAAFAFLGDLRSPSSYYNILRQQQQQQQQQQQQQQQQQPQPTTPMNESTQQANKLNNQPRNYPHPFLHTTQRPAAYGPPVSPYVSPHAPNISVDPAAYQQYLHSYYALQPSTHPRSWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H8Q9</accession>
    <name>A0A8J2H8Q9_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS4425</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5087123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H8Q9"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5087123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="66" mass="7203" checksum="66D7231B9DFF0098" modified="2022-05-25" version="1">MSNSLIKVSSTGLSRIFHNVKPSSEMHCSLYTQSECIVSGAATTSQVRIITQLTTVLLLASHYLFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H8R6</accession>
    <name>A0A8J2H8R6_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Similar to Act5C: Actin-5C (Anopheles gambiae)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HICCMSTLAB_LOCUS4440</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the actin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5087183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H8R6"/>
    <dbReference type="SMR" id="A0A8J2H8R6"/>
    <dbReference type="OrthoDB" id="8247644at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048646">
        <property type="term" value="P:anatomical structure formation involved in morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048468">
        <property type="term" value="P:cell development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd10224">
        <property type="entry name" value="ASKHA_NBD_actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000131">
        <property type="entry name" value="Actin, alpha skeletal muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000291">
        <property type="entry name" value="Actin, alpha skeletal muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000047">
        <property type="entry name" value="Actin, alpha skeletal muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000058">
        <property type="entry name" value="Putative actin-related protein 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020902">
        <property type="entry name" value="Actin/actin-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004001">
        <property type="entry name" value="Actin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00190">
        <property type="entry name" value="ACTIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00406">
        <property type="entry name" value="ACTINS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00432">
        <property type="entry name" value="ACTINS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01132">
        <property type="entry name" value="ACTINS_ACT_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0007">Acetylation</keyword>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0558">Oxidation</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAG5087183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="376" mass="41822" checksum="BDAF13C191BB1BBC" modified="2022-05-25" version="1">MCDEEVAALVVDNGSGMCKAGFAGDDAPRAVFPSIVGRPRHQGVMVGMGQKDSYVGDEAQSKRGILTLKYPIEHGIVTNWDDMEKIWHHTFYNELRVAPEEHPVLLTEAPLNPKANREKMTQIMFETFNTPAMYVAIQAVLSLYASGRTTGIVLDSGDGVSHTVPIYEGYALPHAILRLDLAGRDLTDYLMKILTERGYSFTTTAEREIVRDIKEKLCYVALDFEQEMATAASSSSLEKSYELPDGQVITIGNERFRCPEALFQPSFLGMEACGIHETTYNSIMKCDVDIRKDLYANTVLSGGTTMYPGIADRMQKEITALAPSTMKIKIIAPPERKYSVWIGGSILASLSTFQQMWISKQEYDESGPSIVHRKCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H9A0</accession>
    <name>A0A8J2H9A0_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidase S1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS4675</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5087995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H9A0"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035166578" description="Peptidase S1 domain-containing protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5087995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="231" mass="26377" checksum="EC9A64483231122D" modified="2022-05-25" version="1">MIFLKICVLLLFIDFGFGYIIRIGDSDEEIVDGWHLYLRGAYSKNLYVCEGIFIHGQIFLTDPYCIHSIIKQYAINEVFISNSPDKSSTRIPVDLKANLYYNENLSNGYDESRRQTVFIVTKEQIVINHDHEEFIELPKNVKDVDFSSCFLREHGKYVASVSPCSVEDHNNVIICSYNSHVSVGALVICRLKDHPMTLVLVGISSQHKFLKNNGTKSSIELENYWSVVTAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HA23</accession>
    <name>A0A8J2HA23_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Phosphodiesterase</fullName>
            <ecNumber evidence="9">3.1.4.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HICCMSTLAB_LOCUS3737</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>3',5'-cyclic AMP + H2O = AMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:25277"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58165"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="3.1.4.53"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="9">Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Purine metabolism; 3',5'-cyclic AMP degradation; AMP from 3',5'-cyclic AMP: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the cyclic nucleotide phosphodiesterase family. PDE7 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.-" evidence="9"/>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5083122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HA23"/>
    <dbReference type="OrthoDB" id="189220at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004115">
        <property type="term" value="F:3',5'-cyclic-AMP phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1300.10:FF:000004">
        <property type="entry name" value="Phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1300.10">
        <property type="entry name" value="3'5'-cyclic nucleotide phosphodiesterase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023088">
        <property type="entry name" value="PDEase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002073">
        <property type="entry name" value="PDEase_catalytic_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036971">
        <property type="entry name" value="PDEase_catalytic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023174">
        <property type="entry name" value="PDEase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11347">
        <property type="entry name" value="CYCLIC NUCLEOTIDE PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00233">
        <property type="entry name" value="PDEase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00387">
        <property type="entry name" value="PDIESTERASE1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109604">
        <property type="entry name" value="HD-domain/PDEase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00126">
        <property type="entry name" value="PDEASE_I_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51845">
        <property type="entry name" value="PDEASE_I_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDEase" evidence="11">
        <location>
            <begin position="42"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="370"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="561"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="636"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="706"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="750"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="895"/>
            <end position="953"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="370"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="389"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="404"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="652"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="668"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="750"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="776"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="905"/>
            <end position="916"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="938"/>
            <end position="947"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="6">
        <location>
            <position position="126"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="126"/>
            <end position="130"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="130"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="166"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="167"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="167"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="167"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="276"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="276"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="327"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00061458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR623088-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR623088-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR623088-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAG5083122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="953" mass="107487" checksum="976B77DB7CD7505B" modified="2022-05-25" version="1">MRFSETENLLLENLNVENKRARHTGRFLTMHKRRRKKLTTRSLNQEPGLLDDIFHGQVQCVLQRAGHWRFNAFTLETVSGGRSLPVLCVHLFQSYGLINRFNLDVVRVWKLFALIEEGYHSTNPYHNSIHATDVTQAMHCFLQEDKIRRHLTSLEVMASLIAAVTHDLDHPGVNQPFLVATSNHLATLYENTSVLENHHWRSAIGCLLESGVYQQLSPELRPPLQQHISSLILATDITRQQEFLARFKTYLDTRELDMSSPNHRHFILQIALKCADISNPCRAWDISRKWSYKVCEEFFRQGDYERQLNLPVTPLCDRTVMSIPKIQVGFFEFVVTPLYQEWHRFLNSSPLSLKLMSNLRSNHQRWQKLTNSDVSPSSLSPNNSVTSNGSRNRSGAPSPETSMLRASSEELSSVELPSITNQGTSSVAASLTVPLNVHGRRHSVPLSLNKSSRIGRRRESVPCTPEFPKIFKNSSFNKLSSLSLLSTHSDVSSENERPVSAENLLPEPSIASITSAAAASKLCNILQPERAGKLTRQQTFPPLQPCNRTRYMSTTAEMAQCRGEELKEQEEGEENKERKKKKKLDSRSYTLVEQKIEKKFTDRRYSVQVIADKEERTFRSHSVTDTAAIYANLTSRKDSESNSNSNSREIELGEFQEEDWGGEENTGDECRPLPGKVRDDRRFSTPVDGLKGTIFEARRFTEPRVFFIGSPPESPPRKSNSSSSEGSEKVGEEVSRVRAVKIIKLETKENVDPRGEDGKRKGWTRRGSAPVGLMARIDDAGGRSDRRGSVPTETEQVTGRSALGPRENVPLPRRASLPQETALNNLLGISTDYRENYPLNNNNLGVNNNTQIQQIRLVESVSSSGIGIPSSPRRGSVPADISELRREYLIRNASSAGVTAQNKSRNNRKKSLRRRSSGGPEMFSNPTDDNDNASKCGWKRDFKRDSSIPEPSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HAG4</accession>
    <name>A0A8J2HAG4_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS5682</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5090572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HAG4"/>
    <dbReference type="OrthoDB" id="7700450at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2590">
        <property type="entry name" value="BEN domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="102"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="204"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="217"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5090572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="406" mass="46486" checksum="BA963F69078F8DCB" modified="2022-05-25" version="1" fragment="single">MVHQLYALVKWIDDGIDKNKYTPDVPIEWILGFDLKQFNANAVNEEESDVIEWRDTKNKPKSGWKLFNGIVIDISSRRSTLEEKLRKLAGKISPIKIIKKDDSYRNRERSRDRSRRNFDTSGKAQGDTRDLNGNKRRDDNEIKDRHVRKEVPPRTRSRSKERDYFLLNRPLANKHGDERNDGLSDDGSINNLLHNDARKKNHDSNQILNSQFSKSNESIKKHKEDPKKKPMIIDQRLITPKVLKSISEEHILTSIANQNKVIDAMKKKIQEFENINQAGNRLKASNKVTSAMTGYCPLTEEKIYARPTSLNEVEIGRKGSGIVIEADQWDAAMEKNTFTAMGISLLSAVFHMDTLLHSNVKGGKSKIHQDAEMPKHDALDSTVLTAIHFTVKNVHPTKYEKAKLNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HAP1</accession>
    <name>A0A8J2HAP1_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS5582</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5090318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HAP1"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5090318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="60" mass="7104" checksum="ED10AFCC37BC091E" modified="2022-05-25" version="1">MAAATLNNEINNSGSRRYVFYFQIDDQPAYRVENLDFQTYLKIKHDNNEAFAFITRLIEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HAS5</accession>
    <name>A0A8J2HAS5_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS5673</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5090545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HAS5"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="168"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="32"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="47"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="103"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5090545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="206" mass="23406" checksum="4E64D7C1E47DCA94" modified="2022-05-25" version="1">MDKKREGDEGGPSTTGSQSSKVLVTENTADESVSKETEREPQKTSDENDMILDEIDESERSESAAGSETTEGADDNSQAKSKGRLPMALTWSRHRANSLGEIGDIRNWARNDQPKRKGTGVDDRESKVRLVTSRTEKKRESLENVMEMGFKRIMDRFDEEKSERKKHYKEIKTEFSKLEKRNKELEEKVGKIDVEMKASCNASNIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HBH9</accession>
    <name>A0A8J2HBH9_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HICCMSTLAB_LOCUS5966</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5092184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HBH9"/>
    <dbReference type="OrthoDB" id="19174at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24134:SF9">
        <property type="entry name" value="ANKYRIN REPEAT AND SOCS BOX PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24134">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN DDB_G0279043"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="427"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG5092184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="892" mass="103922" checksum="E8FC4E7FDCC0056A" modified="2022-05-25" version="1">MVNQDDLMELLVNDYKADVNAMAADGTQPIHLACFYQPIDDSKNYPYKRSIVGSKIEIETLVKANANVDAVFGQEIFSKHVKGKKWCPDFGDKMPLVAYTIIYDKPSIIDHLKNSILKDMGNSDSLKISCNLVLPLSAQIFVVMYYQVGGLADMYALINKDPATFLPNLAAYRTNRLLLSNLLPFYTSMPLSRVLYYATLPIDEDSKYLVRANSEAERIDYLERVRGDRELCIEIALKDLVFRGIFRLPVPEEEIKLMDELIASDENLRWIVDDYKKNFIGKELKEHFIEFGNNKMTIYDFLMQVFDDKKLKFLAREEDLLDALDDVFGSLAMNSDNDDFYYNYKYPIKNRIENVEERLGLLENLKKIPSLRKAIPLPYELKRRYKMDPGNSLMYQAIEDHKLEDIKLLLENGIDVNEPIITTGEFAGFTALHVACMKGKNHLVELLVNDYKADVNAMATDGTQPIHLACFYEPISETNPWQPEPVVGSIIKSLVKANANVDAEFGQEIFSKHVKDREWCPDFGDKMPIVAYTVIYDKPSIINHLKKVNLDIISRTNKTLLMYAVEKECVHYNSYMMSNVDDPWLRDKLINHRDNDDVPLTHYLLHPKKYGIFRYQDSTVFYGYDIDSKLICNFVSWGADMYALINDDPATFLPNLSAYRSLPTLMKYSLPYYTSMSLLRVLYYASLPIDEMSDHLVCVQIIRSEFERHDYLEQIRENREVCIEIALSDLIFRSTFRLPVLEEEIKLMDELISSDENLRWIVDNYKKNFIGKVLQDHFIEFSDNKMTMYDFFMQVFDDKKLKFLAREEDLLDALDNIVLRQNDDFSRFYEAYRNPIKIRIKDAKERLRLLENLKKISSLRKAIPLPFELVLDIVEYLNNKHLNIFIKSFYTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HBT9</accession>
    <name>A0A8J2HBT9_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">protein-synthesizing GTPase</fullName>
            <ecNumber evidence="3">3.6.5.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HICCMSTLAB_LOCUS5115</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.3" evidence="3"/>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5089126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HBT9"/>
    <dbReference type="OrthoDB" id="2067at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070125">
        <property type="term" value="P:mitochondrial translational elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03697">
        <property type="entry name" value="EFTU_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000085">
        <property type="entry name" value="Elongation factor Tu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050055">
        <property type="entry name" value="EF-Tu_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033720">
        <property type="entry name" value="EFTU_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009001">
        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004160">
        <property type="entry name" value="Transl_elong_EFTu/EF1A_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43721:SF2">
        <property type="entry name" value="ELONGATION FACTOR TU, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43721">
        <property type="entry name" value="ELONGATION FACTOR TU-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03143">
        <property type="entry name" value="GTP_EFTU_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50465">
        <property type="entry name" value="EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="8">
        <location>
            <begin position="1"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAG5089126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="349" mass="38504" checksum="A8D8017C4F02D310" modified="2022-05-25" version="1" fragment="single">EFKNCKYVPFDQIDKAPEEKARGITINIAHVGYSTKLRRYAHTDCPGHSDFIKNMISGASQMDGAILVVAADDGTMPQTREHLFLAKQLNIKHIADLVDDELLDLVEIEVRELLTDLGFDGISAPVIRGSALLGLNGDNSKFGVPAIKDLLDAVDNYVPTPKRDYESPFLLPIDNVISVPGRGTVVVGTIKRGIIKKNAPADLLGFDEQTRTTVGDIQIFQKSVPQALAGENVGILLRSVKYNNVFRGMMLCQRDSLPSTNHFEAQISTWSVQCRYDLMLGQGNNMLMPGEQCSTKLTLIKRMPMMVGQTFTVREGRNTIATGQITKLLKPLIVDKRKLNQVVVPGLNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HC20</accession>
    <name>A0A8J2HC20_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS6465</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5092946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HC20"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5092946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="48" mass="5485" checksum="B29EDEAD49CEDC73" modified="2022-05-25" version="1">MPFIWLRMSIPWELFKLKNSPTSPPPILAITVETAARAEYFHLSSVTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HD16</accession>
    <name>A0A8J2HD16_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS5842</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5091017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HD16"/>
    <dbReference type="OrthoDB" id="10461621at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5091017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="436" mass="50466" checksum="28149425BE60B24C" modified="2022-05-25" version="1">MMMATIPTATTYQVLHAVATEKVNEKTEATDEVLRKLMTMSLLPHNKIEAEFEQLKEDCTDDLKNKLEGLFTYYQSKWITDFTPAKFSLFGDIGSINDCSEIHQRVLLNKLQSDNPGFWKFIGFVSINFSKITKDYEKIINDDNKRPTYVSQINKSFDSIGNKDLPSKVQELWQQLTENIINPSEFLERGFNVMAGYYNDLFFNNYILPEELTIVSHDLYELRKNNYHYFKHYCVLKFLYNCLSFFFLANEYVPNIRNQIDDGDVIEERPFARRSRSALDEIERIVNELQPTDDDNEVVDGNYLYDSQCSRCKVKLVTTINFPCKHVEMCSGCASGRSHKLCSVCQKTIARTERIFLPTDTEGEGYCLNCEICAEQPVSIMWNACNQGLTCKRCAVRVVTAGNQSRITERTKLQCPHCNIETDGMIEFKLRRKNNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HDJ8</accession>
    <name>A0A8J2HDJ8_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS5393</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5089835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HDJ8"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5089835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="105" mass="11866" checksum="9FAAEAA21EB583DA" modified="2022-05-25" version="1">MALVSPGIMFRAKFYCDARDANGSTGDIIPDRVVRQWRRHFLLVGFYSHEHIHYFLAGAGLLSLSPLLSFKSPAEFAHFGQEVMMDTGIAVFWGKEKNSICKMLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HFA4</accession>
    <name>A0A8J2HFA4_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Similar to HMCN1: Hemicentin-1 (Homo sapiens)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HICCMSTLAB_LOCUS7415</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5094089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6106100at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005911">
        <property type="term" value="C:cell-cell junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050839">
        <property type="term" value="F:cell adhesion molecule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098609">
        <property type="term" value="P:cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000032">
        <property type="entry name" value="palladin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051275">
        <property type="entry name" value="Cell_adhesion_signaling"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11640:SF164">
        <property type="entry name" value="MAM DOMAIN-CONTAINING GLYCOSYLPHOSPHATIDYLINOSITOL ANCHOR PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11640">
        <property type="entry name" value="NEPHRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13895">
        <property type="entry name" value="Ig_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="2 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035182381" evidence="8">
        <location>
            <begin position="17"/>
            <end position="1857"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="973"/>
            <end position="998"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="9">
        <location>
            <begin position="369"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="9">
        <location>
            <begin position="466"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="9">
        <location>
            <begin position="582"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="9">
        <location>
            <begin position="670"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="9">
        <location>
            <begin position="790"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="9">
        <location>
            <begin position="877"/>
            <end position="954"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="29"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1101"/>
            <end position="1156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1285"/>
            <end position="1305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1461"/>
            <end position="1492"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1526"/>
            <end position="1598"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1629"/>
            <end position="1681"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1803"/>
            <end position="1822"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1101"/>
            <end position="1111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1289"/>
            <end position="1299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1461"/>
            <end position="1487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1526"/>
            <end position="1553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1564"/>
            <end position="1598"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1629"/>
            <end position="1643"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="1646"/>
            <end position="1666"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1670"/>
            <end position="1681"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAG5094089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="1857" mass="204754" checksum="181CB212ACD5E70B" modified="2022-05-25" version="1">MRYILLNSELFAYVSATIIVTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTAIITMLVVSKPVVAYTQNPIGSTKVRENGVGIGSSVLQLQVGRSELGATFTCKISSLALAEPLTVDIKLDVHGKYSDGTSETSSYLAFTASEYDNGQTFSCFAENSVTRIEGIKPMKEATTIEVLYAPIITMRPANITVNETEDFVIICNYEANPAGLTSVKWLQNDQELELNEDHYEGGVTEQTSLTVKNASASDMGTYKCVLSNSVGESTPENTVDVSILYKPIVKVLVEPEVPINEADRLNVSLTCYVINGNPINLNAVRWYLDGDLLKELPDCNIKNNSTIILNMDDTLTFCDIDPSKLLLEAVGRSFHGNYSCEGRNDAGWGLISPSTPVIVYYKPGPAMISYKPKRVIKGSSLNITCTVTDPGRPAVTGYKWIRGMHRLADQEKSILSIDSVNLRTKANFTCIAYNEAGDGDPATTFIDVAAPPAFINPLAPYHGYVYNAVNVSIGCRVECSPICNVSWIKNNEPINFTVTDRYYVTNVYHPADQSTSDFESIQSNLTWNLDKWPNKQLDRFKDNDNYTCISSDNDVGQGVHSTTHFQVEFPPENMTISKKIIDVIVDFIPDSVKCGAVAHPEPTFRWYREGSTETISQSPVLVFETKVPKRSNGTYFCEATNRHGTLNISTYLNVLYKPECQINKERINGEDYLVCTAVGNPKESNFSWSLKSDNDSLGQLAEIRQGQSYLLLDTAVTNFRTYICIANNSIGSSLPCERGVPGNLPWWFQLEGDLLIIVIIIIVTVVIAIVVCCVIVYLICRRKQMHAKFDRYRTRGDEIIVTRRPIKPFRRGKTTTITQMGIPIHNIVHDEGMIARANRLKAIFSSQLKEPDSFPGISREKTAVTYKRIVPRQRMSYNTPTLAASNCDTSADGTDCGGGDVNINANSNVSRKRKKPGADPGHQGNKNSHIDSVSEGLQPESDAKTFYENLPFHGIQTPPNKCVASPKFARVSALHGTTLTSLSPTCSNSRPLSRATSLCAGSAGNVDSAGSSGYESTPSHLGPHYSYHNMPRNNSPELKYNTFKPRRRKQLNHSHQFYSLRLCRKHNINDDNNNNNNNNNQQKQVEKLEQQRCNFQLYAIPIIKSCPHKSENIKNSISSKSFNSISTVESTTTIPSSNIITTPKKDSILLKKKKSSLSSCLYSHIKSNELLSSSSSSSLLLSTHYKSVINNSQVPPVPTPRRRKTDISQHIYQNIPRPIFPTDSAKQQMNEYDYKDHYQKYQQQKQQEMQQYKYNPSSSSCSNSSYNNNHHHHQLTLPLTRSLYNSSAVNPLLVSLIQTNLTNNLNSSNIITNKKTPSTLGLSSSSSGLTMSAGVKPIGQENDKNNYGNRYKNNDNPISENDYINRNSNSNSNSYSNSNTISDNNTMSLSLSLFHGKKIDFDSCDGNFDNNYQIQNQRQSSTGQRRSERKKHRKHERGNDRRIKHRRSSDGRNNFSNRSSTNDITISSLSASCETSFARIQELGIPENFKISYLNSYHHHHHHHHQQQDNNTLDIDLQQNKNKKFKQNSSNYYSDQIIKDNNKQINFESSKEQINTSTTIATMTTATTTTTTTLTTTPTITTTTTTTTTTTTTTTTTTTPTTSTTTVLDSEAVNSTITVNQYTQLVNNFRDIGQEIDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HFC6</accession>
    <name>A0A8J2HFC6_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS6551</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5093050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HFC6"/>
    <dbReference type="OrthoDB" id="10027367at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5093050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="253" mass="29037" checksum="360716F9D4E111E6" modified="2022-05-25" version="1" fragment="single">TFSLPDYIIFKRDRNLVHTDTGRFVQGGGCYLDVKLTSGSHLLLSCVCRRPNGHTLFNFFNVYSKYSSSSKNSIIAGDLNRNLLESTWASNHFNSLIFVSALHCVPFKEWIKKFLVLGLEKLDLESKLGTFFKSDSPFISGHDFLFCEYLVYLSKPSDKTIIYRNFKNCDHTVLSDSLLKIFNINDNDTMKNFNPNDLLTFFLSNVIELVDEHAPFIIREKLQIILISGLPKNLNLNIASEICCTKERKELRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HG54</accession>
    <name>A0A8J2HG54_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HICCMSTLAB_LOCUS9569</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5100469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="7679028at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052192">
        <property type="entry name" value="Insect_Ionotropic_Sensory_Rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42643">
        <property type="entry name" value="IONOTROPIC RECEPTOR 20A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42643:SF24">
        <property type="entry name" value="IONOTROPIC RECEPTOR 60A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="581"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="641"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="818"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1589"/>
            <end position="1611"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1649"/>
            <end position="1672"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1826"/>
            <end position="1844"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="115"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="128"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAG5100469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="2397" mass="278385" checksum="56D9B29EC9F6503A" modified="2022-05-25" version="1">MVKTRWNSEFDMLERMKRLQQPLSDVLSRCTTIPGLSGTVSHEFYSCIGPENKGFVVSLSQRTTGVQENRALTQPEEELLVAWEAKSSLPSPFFCLFSFVLGDLDNITSPLTAPLSAGADESDHDTTDNNNNEINSIDDSDQIHEIYQNDADKPLAYNFSKNLIQSLKIRFSEIESDTLHRKCSFLDPRYRDYLFPDEKTKEEIKKEIKDEIIAYKLSNETYQVESESISESASVKPTKFWDFMKQRRTMQPKIGLDLFNSMMKYLFDNCRTEFGTIGFWGIDRIFLADDEIDFVLLNDSEVFERSPTRRIKFLVKIYEGFNLRRPIINLFSAVPTPEIETVFVFDKGGYRPTIVADEFEWYQELFRNSKVYYCFEWERQIGIITLNSFADVAPAIWMKDPRIYMHINPDNSSVQWWIYVTLFTETIGFNVAKSVVCKNMFFDRTKKLNGYTIRAAANINYHFDPIYKKIDGLITKASDIRQAIALLDLRVGEFSKALVDYLDVSIEITHGIPVNITLNPLRLLMRGIIEIYLSPSSLKDKNEEFDATNHVHLSYPFYFFYEQIVTHNRGLATPLEKMFEFYGWLTIIATSIILLGVLIVIYLSKSKHSSKFTFAVFECLRLLIGNSIYTRMDTDKMRIFFSVIFLYFLIIQATFSGHLAAFLTKPVYRKNVETLEDLEDPRFTKIYATEGSRDYVTDTPLYNKTIFDEYECAKYMCIGDPSVACIDEQNYLIPLIAIYHLHTPKNFIRVSYATLTMPHNSALKHRVNNLLMRLAQSGILNVWNKAWKELLCKNATNYLKKIEDIIENYYRPIVLRDMTFAFVLLGIGLFFAIISFILENSLKTFALNKTKISSWPSSVKRSTIHSVRFVVSEFRILLKWLYISLVKVVGWEATSKSLNLLAIRLTSKMMKLIALMLVQNIVIGQIQVPPEDGLDLFNNMMRYLFNNCRSEFRSIGFWSTDKIFLVDDEVDFVLVNRSSVFRRPPTRRFNFFVAVITKFDHRMPAVRLRTVEPTLRIENMSVFDESGYRKPIMLKVFQWYQKKLKNSKVYYCYMQNDEIVIITLNTFANIAPTPWIGGQFIQIIGIDRLWSTFKITYNKEAKFIYAGFELCKNMFFDCTKKLDGYKIKAAAILKNRSKKKFRKLEKSITKANYTSQGPYMITKRIKRVSKILTNYLNVTIEITHRTILGNQTSYIAKLIEHGSVELCLTPTILVDTGGKYNQSSSRSSNLLTVSLTLKMKKLIALMLVQSIVIGQVQVPLEDGLDLFNNMMKYLFNNCRTEFGTIGFWGIDRIFLADDEIDFVLLNDSEVFERSPTRRIKFLVKIYEGFNLRRPIINLFSAVPTPEIETVFVFDKGGNRPRIAVGEFYWYQKLFRNSKVYYCFEWERQIGIITFNAFADVAQALWIKVPQIYPSINPDNSSVEWWNFGAIYKKETKFDYVGSQLCKNIFFDRTEKLNGYTIRAAAKIYNYFDPIFKKIDGLITKATDIEQLTAVFSLRRGLFSKALVDSLNVSIEITHGMPIDITLNPFELLMSGDIEIDLTLTTWMNNDGEFDMMNYVHLSYPFFFFYEHIVTQNRGLATPLEKMFEFYGWLTPIATSIILLVVLVVIYLPKSVNSSKFSFAVFECLRLLIGNSIYTRMDTAKMRIFFSVIFLYFLIIQATFSGHLAAFLIKPVYRKNVETLEDLEDPRYTKIYAGIRNADYINGTPLYKKTSFGKNECKKYIVDPSVACIDEQSYLSPLIATYKLHTPKNFFKLNYATLTMPHNSALKHRVNNLLMRLEQSGIRNAWISLWQELTSKNLTYHLRKMEDNVENYHRPIELEDVTFAFYFLGIGLFFAIISFILENSLKTFASDKIKITSWLSTVKQSTIHIVHFVIFKFRILLKCLYINLVNVVDWQVTSRSLNLLAVSLTLKMKKLIALVLIQNFVIGKIQIPPEDGLDLFNHMMRYLFDNCRMKFGTIGFWGTDRIFLADDEVDFVLLSDSEVFKKSPTRRIKFLVKIYEKLNLSRPMINLFLAVPTPQIETISVFDKGGYRAMIAAQEFEWYQNAFQNSKVYYCFVKKEEVAIVTLNVFANIAPSPWTRNLFNQLPQSVLPSITYRTRYDKQTKFNDAFLTKPVYRKNVETLEDLEDPRYTHIYANVMSVHYIKGTPLYNKSSFSENEYEQYIRDPSVACIDKQKSLLQLIPRYKLYTSKNSIRFSYSSLSMTHNWGLRHRVNNIVMRLAQSGILDFWDKNTVKKTKKIFETSEYSTENYHRPIKLEDVIFAFVLLLIVCHQFTPHTALIATVSDQPSWCQIVATNLPTTCGQLPNLKLLTSSWLQVSEKNKTNLLPQYVAKFLEKLVVNLVRKNFESNFCRQLGEQPSSFPRLAANLVTSCCSKSTESCDRFGYQGDTKLRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HH25</accession>
    <name>A0A8J2HH25_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS7513</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5095046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HH25"/>
    <dbReference type="OrthoDB" id="7762929at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5095046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="119" mass="14075" checksum="1E216A6F51B16BF5" modified="2022-05-25" version="1">MSFNSFTHWTPAVPFKKPDNIISSEYASLKVFTPSYEKESYIPMEELIAFEYQRIWLSERDEWARKTFPPKNNHRFSQRRDSKNIQKNKNGTIKNDGNKSSSKTNESTVKNNKPRKVKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HH98</accession>
    <name>A0A8J2HH98_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Serpin.3_Cc</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS8764</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5097561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HH98"/>
    <dbReference type="OrthoDB" id="671595at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004867">
        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.39.10">
        <property type="entry name" value="Alpha-1-antitrypsin, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023795">
        <property type="entry name" value="Serpin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023796">
        <property type="entry name" value="Serpin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000215">
        <property type="entry name" value="Serpin_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036186">
        <property type="entry name" value="Serpin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042185">
        <property type="entry name" value="Serpin_sf_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11461:SF278">
        <property type="entry name" value="SERINE PROTEASE INHIBITOR 88EA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11461">
        <property type="entry name" value="SERINE PROTEASE INHIBITOR, SERPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00079">
        <property type="entry name" value="Serpin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56574">
        <property type="entry name" value="Serpins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00284">
        <property type="entry name" value="SERPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serpin" evidence="1">
        <location>
            <begin position="32"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5097561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="184" mass="20286" checksum="7B55629FD4C6AF6B" modified="2022-05-25" version="1">MYIFLPPFVTTKARRGFRQVPAAGKTVGVNRDGIQQLIERMTSTERGVEELYDILDRGMLEREVELSLPRFTVEKELPVSSLFGALGAGELLEPGKADLRGFLENSSDNLHLGDAVHRAKIEVNEEGTTAAGATAIFTFRSSRPTEPAVFNANHPFVYLIYEKPSQSIIFAGVFRTPTSPAETN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HHA8</accession>
    <name>A0A8J2HHA8_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Similar to ppp1r10: Serine/threonine-protein phosphatase 1 regulatory subunit 10 (Xenopus laevis)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HICCMSTLAB_LOCUS7630</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5095280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HHA8"/>
    <dbReference type="OrthoDB" id="2138378at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072357">
        <property type="term" value="C:PTW/PP1 phosphatase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008157">
        <property type="term" value="F:protein phosphatase 1 binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.10">
        <property type="entry name" value="Conserved domain common to transcription factors TFIIS, elongin A, CRSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035441">
        <property type="entry name" value="TFIIS/LEDGF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017923">
        <property type="entry name" value="TFIIS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46557">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT 10-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46557:SF1">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08711">
        <property type="entry name" value="Med26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00642">
        <property type="entry name" value="zf-CCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47676">
        <property type="entry name" value="Conserved domain common to transcription factors TFIIS, elongin A, CRSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51319">
        <property type="entry name" value="TFIIS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="TFIIS N-terminal" evidence="8">
        <location>
            <begin position="70"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="7">
        <location>
            <begin position="1226"/>
            <end position="1254"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="5">
        <location>
            <begin position="1226"/>
            <end position="1254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="291"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1161"/>
            <end position="1209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="291"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="386"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="415"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="468"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="483"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="528"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="570"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="707"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="753"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="1161"/>
            <end position="1180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="1200"/>
            <end position="1209"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAG5095280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="1259" mass="138290" checksum="5EBEED3FD43FEC9F" modified="2022-05-25" version="1" fragment="single">PRIDPLSLLKCLGVLLGPNGGIKGKAEVERLAGLMIKFSKKLVSKCIYIQILKSTDPELLSQFMGAGGWNLIHMWLTDGIVAKNWALVQELLELLLLCPVDVDRLKSNNCPKLIKGLSKEGSHQGVRMLAGKLVEQWLKLVKGETPPNTVPTQISVVNNGSTSNATYTPSVVVNSSVNATRQGDNKTKPDEATNSIESTTVRVQDLALNTPINQDSQQFLQPQQPQKIHLQPVQLQLLNKALPGQLQPSQIKNQFVVVENYQNQPTSIRYKIILRDGKQVLTKLETDASKVSNNINDSDSNVDNKMDIKQDSIINDDDDDDDNNKMLENGQVYDSNNDNNCVGDKLDENSTSTVVKEEADVDTNDQVDSSKLKTEDNVNSESNNKSSDKENRDSQKKDDKSSSSSSSSSDKKSSHSSSSSRSSSKHSSSSSRSSSRKSSSSHRSGSSSSKGSSSSSKSSKDKDRHHSSSSSKHSSSSSSSSKSKSDKEKERDKEKEKQKKDQAEKDKATLEKVQGQSLSNKIGKIPKKKPEDEKSGESLRKTSTDSRDSSKENKDKDKGDSKKPSSPTILEKKNISISIENRKNSQESSRPKTVKTFNSKFRSTGLEEEVKPPPPRTAGKKPSTTATTVTADKKIVPPKLPVKRSSPIRESGASAEKKAKVSLDPTNSPSEDKKGAIKLIAPKPKPMVLQESDMFMDALTASTKSKEPRKRKRRTSVSKDGSTDPKKSDGTNSVSGDQGARDTTPPPTSPSHNTDDRSPVSMKPEFKFYQDTLETDEDKEDKERAQNDKDEDSPDEKVNNKSVNDEEDERSRTPTCDDDSEEATKAPASPDDPEDSGRAPSPNEDIRYVDGLRSVLLLQKRKGPKKSLKWKTDLESVRYFELDETERVNVTKTFTDAKNMEKMNEREAFQMARKLSTEDLMEEKTRWKALIPIDLPAPLADPGKDSKEKDIQYAREKGILQALYFNRNMIPDSPAEPDEERHHIYTDPKIIPLDDISENASKDSDKDFTAVPWPEPKPQQATPVIPNVHFPTFPPHNQVIPGMPMPNQMGPMTMPPQQIPPPMIQPPMNHMQPIQDVPGAGGWRTGDGKVVVPDVAMNNIPNMPGNMNHNYPPPGMDPSMMPPNMMGPPGMYNQQDGYPNMMPEDGSFGHMPNNFQGPGMFGPPGPGPGPNFPNGPPPRGVGPMHGNRGRGGPPGPPGWFRGGGNPGVGPPMRGGWGGRGGWRGNGKQPPVCRQFTKSGYCRVGDKCQYLHPGVNCPPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HHW5</accession>
    <name>A0A8J2HHW5_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">tRNA(His) guanylyltransferase</fullName>
            <ecNumber evidence="12">2.7.7.79</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">tRNA-histidine guanylyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">HICCMSTLAB_LOCUS9186</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Adds a GMP to the 5'-end of tRNA(His) after transcription and RNase P cleavage. This step is essential for proper recognition of the tRNA and for the fidelity of protein synthesis. Also functions as a guanyl-nucleotide exchange factor/GEF for the MFN1 and MFN2 mitofusins thereby regulating mitochondrial fusion. By regulating both mitochondrial dynamics and bioenergetic function, it contributes to cell survival following oxidative stress.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 12">
            <text>a 5'-end ribonucleotide-tRNA(His) + GTP + ATP + H2O = a 5'-end phospho-guanosine-ribonucleotide-tRNA(His) + AMP + 2 diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:54564"/>
            <dbReference type="Rhea" id="RHEA-COMP:14193"/>
            <dbReference type="Rhea" id="RHEA-COMP:14917"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:138282"/>
            <dbReference type="ChEBI" id="CHEBI:141847"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.7.7.79"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="14">Binds 2 magnesium ions per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Homotetramer. Interacts with MFN1 and MFN2; functions as a guanyl-nucleotide exchange factor/GEF for MFN2 and also probably MFN1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 12">Belongs to the tRNA(His) guanylyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.79" evidence="12"/>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5099691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HHW5"/>
    <dbReference type="OrthoDB" id="62560at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008193">
        <property type="term" value="F:tRNA guanylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.3000:FF:000001">
        <property type="entry name" value="tRNA(His) guanylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025845">
        <property type="entry name" value="Thg1_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024956">
        <property type="entry name" value="tRNAHis_GuaTrfase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007537">
        <property type="entry name" value="tRNAHis_GuaTrfase_Thg1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038469">
        <property type="entry name" value="tRNAHis_GuaTrfase_Thg1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12729">
        <property type="entry name" value="TRNA(HIS) GUANYLYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12729:SF6">
        <property type="entry name" value="TRNA(HIS) GUANYLYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04446">
        <property type="entry name" value="Thg1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14413">
        <property type="entry name" value="Thg1C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028980">
        <property type="entry name" value="tRNAHis_guanylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12 13" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="7 12 14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 12 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 12 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 12 17" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 12" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="tRNAHis guanylyltransferase catalytic" evidence="15">
        <location>
            <begin position="31"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="Thg1 C-terminal" evidence="16">
        <location>
            <begin position="163"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="55"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="100"/>
            <end position="101"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="101"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="101"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00058346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00065710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR028980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR028980-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR028980-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF04446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF14413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CAG5099691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="291" mass="34069" checksum="37938408A3B1F0AE" modified="2022-05-25" version="1">MRSIFSKLNLSVPVIINRFIKTSSVMAKSKFEYVRLYERDNVCLQNCWIVVRIDGKNFSKFSDDHKFLKPNDIRALELMNIAASAVIREFHDIVLAFGQSDEYSFVFRKETSAYNRRETKLLTYVNSLFSSAYTFHWRDFFTECALKYPPSFDARVVLYPSDENLRDYLSWRQADVHINNLYNTCFWNLVQRQNMTTAEAQEKLKGTVSSQKNDLLFDSFGINYNNELPIYRKGTTIIKKLIPDENGKMKSTVLILNEDIIGDRFWKEHPEILDPKAKAKINNLNCKKSKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HI38</accession>
    <name>A0A8J2HI38_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS8142</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5096302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HI38"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="177"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="179"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5096302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="218" mass="23770" checksum="AF9BA225DBB983C4" modified="2022-05-25" version="1" fragment="single">SRAAAVADFNTGSRYVCVTYAIEDSGRLSSLCRVAVVPLAVPKAGYNNASAWRTPAGKWGTATGIDGPCLDTIRVLFSCSSTIREYNQERQRRHSRDAKGASEKKCHKRENSDHTTSTHGHRAAAVTPSAPLRTSAKCILWTTTTTTTTITTTISTITTTTYTTAGALLCTAAMNRTKEKGRGKRKRMSTTRGPRDQEQPCGWSGTTEFTLLFYFFAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HJU7</accession>
    <name>A0A8J2HJU7_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="21">Similar to Nup210: Nuclear pore membrane glycoprotein 210 (Rattus norvegicus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">HICCMSTLAB_LOCUS9839</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NUP210 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5100766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="361283at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058779">
        <property type="entry name" value="Ig_NUP210_13th"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057586">
        <property type="entry name" value="Ig_NUP210_16th"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055096">
        <property type="entry name" value="Ig_NUP210_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055097">
        <property type="entry name" value="Ig_NUP210_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055098">
        <property type="entry name" value="Ig_NUP210_3rd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056897">
        <property type="entry name" value="Ig_NUP210_4th"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056898">
        <property type="entry name" value="Ig_NUP210_6th"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055099">
        <property type="entry name" value="Ig_NUP210_7th"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056899">
        <property type="entry name" value="Ig_NUP210_9th"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008964">
        <property type="entry name" value="Invasin/intimin_cell_adhesion"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045197">
        <property type="entry name" value="NUP210-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055094">
        <property type="entry name" value="NUP210_Ig15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055095">
        <property type="entry name" value="NUP210_Ig_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23019:SF0">
        <property type="entry name" value="NUCLEAR PORE MEMBRANE GLYCOPROTEIN 210"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23019">
        <property type="entry name" value="NUCLEAR PORE MEMBRANE GLYCOPROTEIN GP210-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26181">
        <property type="entry name" value="Ig_NUP210_13th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26183">
        <property type="entry name" value="Ig_NUP210_14th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22959">
        <property type="entry name" value="Ig_NUP210_15th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25354">
        <property type="entry name" value="Ig_NUP210_16th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22967">
        <property type="entry name" value="Ig_NUP210_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22969">
        <property type="entry name" value="Ig_NUP210_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22963">
        <property type="entry name" value="Ig_NUP210_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24991">
        <property type="entry name" value="Ig_NUP210_4th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26182">
        <property type="entry name" value="Ig_NUP210_5th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24935">
        <property type="entry name" value="Ig_NUP210_6th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22962">
        <property type="entry name" value="Ig_NUP210_7th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26184">
        <property type="entry name" value="Ig_NUP210_8th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24902">
        <property type="entry name" value="Ig_NUP210_9th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22957">
        <property type="entry name" value="NUP210_Ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49373">
        <property type="entry name" value="Invasin/intimin cell-adhesion fragments"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035250528" evidence="9">
        <location>
            <begin position="29"/>
            <end position="1913"/>
        </location>
    </feature>
    <feature type="domain" description="NUP210 Ig-like" evidence="14">
        <location>
            <begin position="29"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="NUP210 Ig-like" evidence="15">
        <location>
            <begin position="128"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="domain" description="NUP210 Ig-like" evidence="13">
        <location>
            <begin position="246"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="domain" description="NUP210 fourth Ig-like" evidence="18">
        <location>
            <begin position="356"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="domain" description="NUP210 Ig-like" evidence="17">
        <location>
            <begin position="533"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="domain" description="NUP210 Ig-like" evidence="12">
        <location>
            <begin position="643"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="domain" description="NUP210 Ig-like" evidence="16">
        <location>
            <begin position="897"/>
            <end position="974"/>
        </location>
    </feature>
    <feature type="domain" description="NUP210 Ig-like" evidence="20">
        <location>
            <begin position="1167"/>
            <end position="1281"/>
        </location>
    </feature>
    <feature type="domain" description="NUP210 Ig-like" evidence="11">
        <location>
            <begin position="1386"/>
            <end position="1487"/>
        </location>
    </feature>
    <feature type="domain" description="NUP210 Ig-like" evidence="19">
        <location>
            <begin position="1491"/>
            <end position="1554"/>
        </location>
    </feature>
    <feature type="domain" description="NUP210 C-terminal Ig-like" evidence="10">
        <location>
            <begin position="1602"/>
            <end position="1733"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF22957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF22959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF22962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF22963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF22967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF22969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF24902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF24935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF24991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF25354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF26181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="CAG5100766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="1913" mass="212179" checksum="26480FCAF862D418" modified="2022-05-25" version="1">MAGLKFLLKIVIFIICAITQSTWNIASASRLNVPRVLLPIFNDFPVNFTLEVTEGGCYQWSTSRLDIIHLIPINENPDHTCSSAVIVQSVTRDLTRNTAIVLAEDINTGQFLRCDVIVDVIYSLSLVSTTRELFIEEAPEAFEVRANDDQGNEFTTLTGVEFIWTIGNGDKSSSLDTANSVLRFITFQESPYETPSSIAMLDGTGKTGSIVLLEGVKTGTAKVAAKLPHIEYKDVPSVEVELIVVANLIIIPTDVTVMAFDSIKYKIMQVHQGRLEKINLPFSQYYLEAEHPDTLDIDNDSGKAYALSNGKTKVSLHDKNVNEDYGIVLPTATVNVNSVDYITITVLPNRNRGLILGETHEIIVELFDTKDHKFYIGDGVEVMITIDSKYFHTKFTSKNGTYVVGVPISCGTTTVEAKLHGVIDKNGKKIPLPTPLVAKADLIIHTPVIINPKILAVPWDPKSKSRLDVPLKASGGDGTYVWNSRQPSIATVSQNGVVRILNQGTTDVIVSMARNQFNNDRAKVYVMLPTRLEIIQYSMDAATGEPIHLYVALYGKLNNTPEAKEMPFTDCRDTLFEIYISDNNFVRNSTSESVQPIGISCTTLTVIGTDIGSSSITVAYRANGQYLMDNVTVSAYEPLTSIHPSSAETLLAVGSSRNIIFKGGPHPWTGKPNSFAREIALSDEEIIQVNELDDTVGVSIFKVTCRALGQATLTYKVFNKPFFPNCYSTGATAIVQIICSKPRYIYLQPEFKDSKNCPIGNNAERIMAHANQPLRLVVVVKDEDGKRFDNITSLNIEWTLKPSGIGSFQVSTGILEQTFVDYNVILPMTHYQTVIPKKHMGTLTISAKITDYQKFILAKLKIIPEWPPFPITTEKGNLVTPRITAELNILLVNDTVITPKKIKLLNDPNIKYSLQVNQGSGYYEFILSVDDIADVRYIEPTKTISVIPKKAGILQVALKDLCLDSAPAIAEIQVQQLAEIEIVSVNKVEKDKCILAAVKLFDTIGNLIELPSLEAFDLHPEVDNKFIELVKLPINEQGQSPYSQILYMIHGIQEGESRLNFISGYGDQEIRSESNIIQVFMPLKVTNNNITILIGTIYQIMTIGGPVNAQIEFTVDNEDIVTINNEGIFEGKMIGSTKVIAEAVGLDSKGTRVVYSQDFVNIHVITLEGIRIVTPTSRIKVGATIPLWAFGIPDQLTPLVIGSLKSLLVFTWYSSDSNLINLHNMYEGTGINIRYQNEVTLRATALKSGSTTVYLNVTIPSKILSSFKEDVTFSTFIKIEIIEELRLINPEITDSMPVILMTPNSSLKLQTNKDNSGITTYKIVVSGHLNESAEPNALTATKTVTVDKNGMIKSGDSIGKTILSITNIESYNRKQTMTIIIDVKPVHYMMLSLSSNVRIRAGEELNVLPKGMELNYIIEYFDNIGSKFHAAELKFDTISNRGDLVTFTSEQSNNQLNVKFHNNGELVAKVYSDKHTTNIFDYVHMMIGDIIFPSKTLLTVGDIVCFSMPLLSTKTGDPGFWQSSKPEILSVDAVTGIGKARNLGQTFVRHSLTDNKQDDIEVNVEPISKISLVSLRGKNITGMEIFSVPLVLKSKDEGIKENNVLARGLRGCRTRTSFTLDSFPFTCTVQFVSKLSSVNIKDIFIAKPRFDIVSGFYYCDIIPIGIPTMVSSTLDTRIQINAHSHDVEGNALEIIYLPPVYIKSSDVTFVQTNPQVIATATLQIYGLKSVLEHTRLQVPEGVVIHSHELTTLSTLQFNLRLMPDKDDIQGQKIIVINELTRQNITLMIRTSRNDYNTLSGINWIDCLCYHQYTIITLAIIIITMIWMWKNKIASVDLSVRNTTVFADQSPPPMKKCPNQVNVSSTINHSINSSSPQRSPESPLRPFSAFEPVYGDPRGFYTPNTRRNISFNCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HKI7</accession>
    <name>A0A8J2HKI7_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to Spg11: Spatacsin (Mus musculus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS9962</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5100889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2018754at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030425">
        <property type="term" value="C:dendrite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008088">
        <property type="term" value="P:axo-dendritic transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007409">
        <property type="term" value="P:axonogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007268">
        <property type="term" value="P:chemical synaptic transmission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048489">
        <property type="term" value="P:synaptic vesicle transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028103">
        <property type="entry name" value="Spatacsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028107">
        <property type="entry name" value="Spatacsin_C_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13650">
        <property type="entry name" value="SPATACSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13650:SF0">
        <property type="entry name" value="SPATACSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14649">
        <property type="entry name" value="Spatacsin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Spatacsin C-terminal" evidence="2">
        <location>
            <begin position="1432"/>
            <end position="1746"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="737"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="737"/>
            <end position="756"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5100889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="1819" mass="209971" checksum="CF4D3898A850414B" modified="2022-05-25" version="1">MEPLGGMPAEWLTTAELAGIWSGWLSMRDREVVRESSAKGTHIQLAHKFLRHRKNVNLEDAQLFFNNEVDIWIDELLNKQQIHRASHILRNVGRDPIAYIRKICIKLPDSKIRDYLVNHVVNSNGFSSDDILAWDIIQCLKKYKDKCKFTDKIFYNKLIPNICIQDILNLDDHLKDSLITELYFITRESSLSSKLKTEIVWDYLLLNNKIDFLINWIDVYYIKRENINSHSENIDSEIFSKLNITSDMIESIDTSDVTVPGKLLLLNHLARYGVFLKKEQEDIKLTLSRLFSASIIPSEFNKILSKEHCCVNVNAFYQNIFSIVYHQKIVNEDFDYDVHLQEKKLLYLLRDISKSSNIDQKDIINAIFQTINNVTNDLSGYLQSNPYLVLTLIIIKYQNDCYLMQQQDGNNKLMNFKDYIHGYDMVIEDLTIKKEVIDEILKCLPYLKDILGENLLERNDISMYQLINGFNNLNVQELFKWRNKNEPLPSFTSEHLIKKYGHKEKLTYKYYLKELRPSMAAYILQKQRSKISNSISSKIKSESAVHAHIYGLKNINDNKIISTCITFIEYLGIDSECLRFHATAANYIKTKLDLPINDLLESITYHNSPKDLAIITNYLEDSFKNECITSMSNVSEFISALKSWDFIVQFSCIHNTKFPSLFLKYLAKNNYWFEFVLVGHIFGYPLEQIFDKAELFKNKNIREHLLISLNNSHLLAETYSRVNLPLIKLPDTRQLNSSRMSRKNGQSSPIVKTNPNDTEELPNVFKYFPLNQINSSYNKDLWLTILKCHQSQDPPGALLKSSRDCKSSIPIVLAACYEPSATAAYCYSWLVISVNDEDLIIDYTNCLNDQIWSAKKVSDLFRRIISLGYMDTLSRGFQIFMPDNPLSIFFDFLVKCIKHADFKSSVDTLNNFLSTCSTFKSNKMIDWTDPDTSYLNNEYWIATVATECILSALGRCSQSIQIQTKVLRILVENNFNSSLNIDGIEFKMLWEIVISLETTDVKIDFTAIKLIDNCSNITQEFKRCIQLLIDNKDFTTALVLSKISNLPCSKIIIDQYRCAFKAHLNQVLKFCSKSIISGEKWDLNFWKKCALDIKKYNVNFEDAAGFFIEHAEKVNSHKERYEILQLAHSTLKPISTDQQTIDTIEMAMWKSCILAGPEAIEINNERRLFNKLKTELLSGVSNLRVSCKLNNSAEEKAIDELINKFIDIEDLETALRISAIFNYKHNDLKILMLCLSIAEGEISPYELNSQHKVLLKELSPIKLQKYSLLRPRGLKRQPEGSTNLLASYDQCDDDVTDIPTSQITTDCIELLEKLVKNLLHGTNVGNKILLLYKLSVSLKRNYQNLLVSKDPIEILYDITGINCPNKFDLIKDVITIYRIKDFEVAKFLAGEIILHITRQIEDGYELSASMWGYPLEVHAHLITDLCSDPSTLGWELIKSVNIRLGHSHGGKRDIVTIKIIIELLIRAHNYFTAACHMEGIAYVLRKCQNIANTLQHLKLWSLLVRLLTGIGRFTEMNYIFQILKENDQFEFLLGKGLDKIVGLKIATMEFCKKQCPDNKELFNLVANHFQLYTEVAIVWENKAKAVIRELLQDIRKENIRLMNNLQTTIKLTRNDKTEKKLQSAITYYTDATEHYLQDSKLNTANKCSHQAQLVALQLSLLNGVGVNHQVNCLLNLSNEEINKALCQTLTFPQTLILVQAYNHNADWPSIIYHHIIINGEIKFLKDFLIYKRLTNGIVQDCVCKYRMEKNLTKQMTQNMQSLIGELNDVECKYVMASQLGFKNMIEAMLSNLTIGSYLKDTVWKQGFNPQEFIGENFRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HKV8</accession>
    <name>A0A8J2HKV8_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to Myo18a: Unconventional myosin-XVIIIa (Rattus norvegicus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS11942</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5104318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HKV8"/>
    <dbReference type="OrthoDB" id="2914378at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032982">
        <property type="term" value="C:myosin filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016460">
        <property type="term" value="C:myosin II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031032">
        <property type="term" value="P:actomyosin structure organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45615">
        <property type="entry name" value="MYOSIN HEAVY CHAIN, NON-MUSCLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45615:SF36">
        <property type="entry name" value="MYOSIN HEAVY CHAIN-LIKE, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57997">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="907"/>
            <end position="926"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="272"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="334"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="649"/>
            <end position="895"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="914"/>
            <end position="926"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5104318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="926" mass="106811" checksum="5EAAD4794C1BB091" modified="2022-05-25" version="1">MSESISSLDVMSTNEFPLPQLSLNSYNSRPINRVAIVTPSLSRNNNYNDDITSFTRSPTPRLASSVSLSSKSYSRSSLCRDSFSSNSFLRSATPRRFFPQDNSLADFSLKHDLSKKEQAPVVFDASLNFVLGIDKQKVRQSFRPTASHLEPETASSLLTSRIAQFLQRTDHIMQEWKRIGGNTNDNELDYLSMPYDKNRPLGKSKSAANIMIKGFQYFNRDNSAARSVSNYNNLRSRLSEDRTLSECDDELSVLTADYAEEHSTSTLAAERIDAETSERLRLERQLEDVTETNKTLQQTTERLEMELLYARAADLNQITLDGEENNQEDGGIYKQRYEHAIRELEFTKRKMAQQHEDDLEQLVGLKKQLEKKLADAYEEVEEQRQVVSQWKRRVQKLNGEMHDLRLLLEEQTARNNLLEKKQRKFDSETQNLMDDLRQEKAQRERLLREKEIAVAEKFTIEQNLSDCKLEMELQEERLTTLSQELEELSYGGKTEEEVMQLKKSKHELEKKCKDQEEELDDLAGQVQLLEQAKLRLEMSIEQQRKEMRKEIQQKDDELEDIRGNAHKKVKALESQLENEHEERTILLREKHELERRLVAFEEQGRNDRAAEADVTQRLKRDLRRTRALLRDAQTMLERSKSDATGKVALRQLKNQLEDAQCAQAVAVKAKQALEQELNETQAALDEVSRSKSEAEDRANAANRERTELISQLEENEEELAQVLKKYRTTVQQLSTEQAALQEAQVQIAALEAEKSSLKDQLMELSQRLESVEQLGDPTANSLVTRRLEFRVKELESKLDLEQTTRARLETQITRLKENVDKLQTESALLRTKEQTAQDTARRLQRSLREAKEEATCAVAREQESTRVRRDLEKALETAEAETKLARDDLRLALQRIDDLQSAIQGELDLDCSEEASTTTDNNSSDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HLB1</accession>
    <name>A0A8J2HLB1_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Deoxyribodipyrimidine photo-lyase</fullName>
            <ecNumber evidence="3">4.1.99.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">DNA photolyase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">Photoreactivating enzyme</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">HICCMSTLAB_LOCUS10533</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Involved in repair of UV radiation-induced DNA damage. Catalyzes the light-dependent monomerization (300-600 nm) of cyclobutyl pyrimidine dimers (in cis-syn configuration), which are formed between adjacent bases on the same DNA strand upon exposure to ultraviolet radiation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>cyclobutadipyrimidine (in DNA) = 2 pyrimidine residues (in DNA).</text>
            <dbReference type="EC" id="4.1.99.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DNA photolyase class-2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.99.3" evidence="3"/>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5101631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HLB1"/>
    <dbReference type="OrthoDB" id="496749at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003904">
        <property type="term" value="F:deoxyribodipyrimidine photo-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000719">
        <property type="term" value="P:photoreactive repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009650">
        <property type="term" value="P:UV protection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.579.10:FF:000002">
        <property type="entry name" value="Deoxyribodipyrimidine photolyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.80:FF:000004">
        <property type="entry name" value="Deoxyribodipyrimidine photolyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000110">
        <property type="entry name" value="Deoxyribodipyrimidine photolyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.579.10">
        <property type="entry name" value="DNA Cyclobutane Dipyrimidine Photolyase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036134">
        <property type="entry name" value="Crypto/Photolyase_FAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036155">
        <property type="entry name" value="Crypto/Photolyase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008148">
        <property type="entry name" value="DNA_photolyase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032673">
        <property type="entry name" value="DNA_photolyase_2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006050">
        <property type="entry name" value="DNA_photolyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052219">
        <property type="entry name" value="Photolyase_Class-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00591">
        <property type="entry name" value="phr2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10211:SF0">
        <property type="entry name" value="DEOXYRIBODIPYRIMIDINE PHOTO-LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10211">
        <property type="entry name" value="DEOXYRIBODIPYRIMIDINE PHOTOLYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00875">
        <property type="entry name" value="DNA_photolyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48173">
        <property type="entry name" value="Cryptochrome/photolyase FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52425">
        <property type="entry name" value="Cryptochrome/photolyase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01083">
        <property type="entry name" value="DNA_PHOTOLYASES_2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01084">
        <property type="entry name" value="DNA_PHOTOLYASES_2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51645">
        <property type="entry name" value="PHR_CRY_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0274">FAD</keyword>
    <keyword evidence="5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="10" id="KW-0456">Lyase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Photolyase/cryptochrome alpha/beta" evidence="15">
        <location>
            <begin position="53"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00033999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00059220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00083107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CAG5101631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="502" mass="58908" checksum="D6A0548CC8FB81C1" modified="2022-05-25" version="1">MSEPQKKKLKSSSLFDKFNDNRQNAASSILDFKFNKNRVEVLSSVDAVAKNSKGILYWMFRDGRVQDNWSFLFAQKLALKNRLPLHVCYCILPKFLDATLRHYKFLIESLEEVSNDCKDLNINFHLLHGVPNVVVLDLIKKHKMGALVVDFFPLRVPLGWVENLKNSIPKDVPLCQVDAHNIVPCKVASDKLEYGARTIRSKINTKLPEYLTEYPPLIKHPHDSLFEIPTIDWKNALKDVEIDLTVDKVDWCKPGYRGALAELESFIKNRLPHYNTKRNDPTQDALSKLSPWFHFGQISVQRVILEVKEYKKKYKESVENFMEESIIRRELSDNFCFHNKNYDKVEGTNAWAIESLNQHRKDKREYLYTRDELEKSQTHDDLWNAAQNQMVREGKMHGFLRMYWAKKILEWTPSPEDALAWSIYLNDKYSMDGRDPNGYVGCMWSICGIHDQGWKERSVFGKIRYMNYKGCERKFDVKAFVRKYDGKIVNKKNDISKIFKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HM23</accession>
    <name>A0A8J2HM23_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">GTP cyclohydrolase 1</fullName>
            <ecNumber evidence="5">3.5.4.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">GTP cyclohydrolase I</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">HICCMSTLAB_LOCUS10159</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>GTP + H2O = 7,8-dihydroneopterin 3'-triphosphate + formate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17473"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:58462"/>
            <dbReference type="EC" id="3.5.4.16"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cofactor biosynthesis; 7,8-dihydroneopterin triphosphate biosynthesis; 7,8-dihydroneopterin triphosphate from GTP: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Toroid-shaped homodecamer, composed of two pentamers of five dimers.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the GTP cyclohydrolase I family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.16" evidence="5"/>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5101086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HM23"/>
    <dbReference type="OrthoDB" id="4966at2759"/>
    <dbReference type="UniPathway" id="UPA00848">
        <property type="reaction ID" value="UER00151"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003934">
        <property type="term" value="F:GTP cyclohydrolase I activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046148">
        <property type="term" value="P:pigment biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006729">
        <property type="term" value="P:tetrahydrobiopterin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046654">
        <property type="term" value="P:tetrahydrofolate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00642">
        <property type="entry name" value="GTP_cyclohydro1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.286.10:FF:000003">
        <property type="entry name" value="GTP cyclohydrolase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1130.10:FF:000012">
        <property type="entry name" value="GTP cyclohydrolase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.286.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00223">
        <property type="entry name" value="FolE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043133">
        <property type="entry name" value="GTP-CH-I_C/QueF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043134">
        <property type="entry name" value="GTP-CH-I_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001474">
        <property type="entry name" value="GTP_CycHdrlase_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018234">
        <property type="entry name" value="GTP_CycHdrlase_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020602">
        <property type="entry name" value="GTP_CycHdrlase_I_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00063">
        <property type="entry name" value="folE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006825">
        <property type="entry name" value="PRK09347.1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006826">
        <property type="entry name" value="PRK09347.1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11109:SF7">
        <property type="entry name" value="GTP CYCLOHYDROLASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11109">
        <property type="entry name" value="GTP CYCLOHYDROLASE I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01227">
        <property type="entry name" value="GTP_cyclohydroI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55620">
        <property type="entry name" value="Tetrahydrobiopterin biosynthesis enzymes-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00859">
        <property type="entry name" value="GTP_CYCLOHYDROL_1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00860">
        <property type="entry name" value="GTP_CYCLOHYDROL_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0783">Tetrahydrobiopterin biosynthesis</keyword>
    <feature type="domain" description="GTP cyclohydrolase I" evidence="13">
        <location>
            <begin position="123"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="73"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00017272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CAG5101086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="302" mass="33830" checksum="95F14AE359D5A53E" modified="2022-05-25" version="1">MMNGVKSDTGISVNLANGEKENDKGSKVNGQKSCLCVDKVTVKMNGSSTFVEKESITKNCKKPGPLRNVTWSENVDETDLEVPGTPRTPRTSKTPGHEKCTFHHDLELDHRPPTKEALLPEMSKSYRRLLRSLGEDPDRQGLLKTPERAAKAMLFFTKGYDQSLEDIINDAVFDEDHDEMVVVKDIEMFSMCEHHLVPFYGKVSIGYLPCKKILGLSKLARIVEIFSRRLQVQERLTKQIAIAVTKAVEPAGVAVVVEGVHMCMVMRGVQKINSKTVTSTMLGVFRDDPKTREEFLNLVHSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HM54</accession>
    <name>A0A8J2HM54_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="16">CYP366E1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">HICCMSTLAB_LOCUS11689</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Microsome membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5103797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HM54"/>
    <dbReference type="OrthoDB" id="2789670at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11056">
        <property type="entry name" value="CYP6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000042">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050476">
        <property type="entry name" value="Insect_CytP450_Detox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24292">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24292:SF104">
        <property type="entry name" value="CYTOCHROME P450 308A1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 13 14" id="KW-0349">Heme</keyword>
    <keyword evidence="10 13 14" id="KW-0408">Iron</keyword>
    <keyword evidence="12 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 13 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0492">Microsome</keyword>
    <keyword evidence="11 14" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="9 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="13">
        <location>
            <position position="459"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CAG5103797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="514" mass="58073" checksum="D0CC031B0D650A03" modified="2022-05-25" version="1">MDSISWYSIYLASIVVSMFGIYWYFMEKQKYWSKRRVPSIKSNVPFIGNMWPVITMRKSSGELYDEFYKSMPKSSMVGLYSFGEPELLVKDPELVKTVLQTNFSSFQRNAMQINPEADPLLSRNPFFAEGERWKQGRSVLTNSMTSGKLKNMALAVRDVCFEFINYLNSQLKLNSGKNVEVDAQLLFARFTSGVVAKAGFGVNGNCFSDEPGSFLEMAKMMFEPSSFSSLKSMLVMFFPMLNSILKTSFVPPKVDHYFRNIVKEVLDARKDGARGNDFIQHLSDTYKLNAEEADGDLDKNDIDLSIAGHAASFLVDGYLTSSFTLTFIAYEIARHPEVQDKLRKEVKQVLAKHSNEITYDAIQDMKYMDLVIKESMRTVPVAQILQKICTEKSKLVGFDGAECQVEPGTKITIPVQALLGDSKYWENPDKFDPERFSDENKSQQHKFVYLPFGGGPRVCVGQRMALLQIKGALAVLLDNFQLKLSPKTKQPLVWAPAVALNIPEGGIWIMIAPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HMD5</accession>
    <name>A0A8J2HMD5_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Similar to si:ch211-233a24.2: Transmembrane protein KIAA1109 homolog (Danio rerio)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HICCMSTLAB_LOCUS11592</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5103603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10051416at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098793">
        <property type="term" value="C:presynapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048488">
        <property type="term" value="P:synaptic vesicle endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20159">
        <property type="entry name" value="PWWP_BS69"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033616">
        <property type="entry name" value="BLTP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056742">
        <property type="entry name" value="BLTP1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056741">
        <property type="entry name" value="BLTP1_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047268">
        <property type="entry name" value="PWWP_BS69"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000313">
        <property type="entry name" value="PWWP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048589">
        <property type="entry name" value="SAMD1-like_WH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31640:SF1">
        <property type="entry name" value="BRIDGE-LIKE LIPID TRANSFER PROTEIN FAMILY MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31640">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN KIAA1109"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25040">
        <property type="entry name" value="BLTP1_C"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25039">
        <property type="entry name" value="BLTP1_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00297">
        <property type="entry name" value="BROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01220">
        <property type="entry name" value="FSA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00293">
        <property type="entry name" value="PWWP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63748">
        <property type="entry name" value="Tudor/PWWP/MBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50812">
        <property type="entry name" value="PWWP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52014">
        <property type="entry name" value="SAMD1_WH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="3" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0812">Transmembrane</keyword>
    <feature type="domain" description="SAMD1-like winged helix (WH)" evidence="11">
        <location>
            <begin position="10"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="Bromo" evidence="9">
        <location>
            <begin position="208"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="PWWP" evidence="10">
        <location>
            <begin position="298"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="389"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="700"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="811"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1443"/>
            <end position="1483"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="2001"/>
            <end position="2025"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="2119"/>
            <end position="2181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="2259"/>
            <end position="2278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="2320"/>
            <end position="2354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="2714"/>
            <end position="2733"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="2982"/>
            <end position="3001"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="3162"/>
            <end position="3183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="3262"/>
            <end position="3310"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="591"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="1078"/>
            <end position="1105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="435"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="449"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="482"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="732"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1443"/>
            <end position="1457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="2001"/>
            <end position="2014"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="2162"/>
            <end position="2178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="2987"/>
            <end position="2996"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="3167"/>
            <end position="3178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="3281"/>
            <end position="3296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS52014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAG5103603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="3372" mass="375058" checksum="1EB7B379F97BC276" modified="2022-05-25" version="1">MVLNTKKMSVRRRTDPAPTQRIWDAIKLTVHQRSLPSNERIVRHFARVYNMTELAAQEELNKAVEDGLVFLKKSQSKGGLDQESYRLPLDPREDDGHDWYCFKCQKAGVVETCQTCFRVYHPRCHTPNNSDQKICQFCEQISADTYHDVKALNHILGFTCGHLKAKLPPEITNRTIVPDSSVVEKPAGGLCGPTWISEGEDSWRPGILIKNHMDLAIMEAKTKRNEYKSLAEFQTDAHNILHNIIVYHGEASVIGEMGKIMYQDCCYDLKEIRRCADCYRISNEKSEKMWFCIPCNPPHQLVYAKQKGYPYWPAKVMEIKGNIYDVRFFGGHHMRANIEKIFIRSITSSLQSLQIKRSTAWNRAFEELKHHQSLLTKLAKSSLLVAHNNNSTNAAGTTDDVEGPKPSKMRRHQESSESSQGSQVASPNGVSPVKLTKDLRVRVERLMSDGNSEIQLNQEKSESANGDGDGDGDGDGVGDGGPDEKPEVKDGSRSTSEERQVPFLPVAIDEEPPLRISSSTCPEGLKKEGSQEDMVTSSSQEPRSKCVLVQTEEVQPETAPAKMKRERRTSEQTTTAPALEKLRREFELDKCRELERLQAEHAKELRQLTEKHQQVISEIKKKQWGVIVLSRQWKNVLYTPLLLEHNYKTKHVKPLNVTFAVSDPEDENLLTDGEGSAGDGDDQEVTDECAMLINTDNIYKHSQVKPGPDKSTGVCGDGLTVPVSSPRGRETSPLSTPIPTGPDSLTSPSPPVAHHKRGRSLQPTQVPVSSRASIVFPLLASGGLFNQPRDPNNINYGTLQEEKMPQIHVSQSHNLGSNPSIYSGGHNSPHSTGSIDQIMSPTAHQSTRQNNAGEDLYSWMAKQQEFIKDNEKSNLKGNWVFRTEQKATKDSKINTMTTEDTEDSDVQSGACLYPMKDSLRLLDAHLIFEPLLSSLSVMPQQMLSAIGSGNINNVSSLESLGSNLSLVGTMDTMRIDIVVSEFGKVPDKKKATKHPPRKGSKFFLDIPSETPAFLCEKIGIDIDIKKMADMTVDDMIQRQNVLYISRGQLKKHTSTVVNFSLNIRYISQQVNMPLLRLLHQISNMYQNVKETQMELKEQLPETKRNANLTVNEINIKNGSSSTSDLQDQHHLGGCNISDGGKKIDEPLLQSSYDNNQSKVLSPSSSIRSRPQSFAQKLRSTGKSVKGYINLSEGVITPSFGASPNGSGLDKFSVLSDKCKDNFILTPRCWRTIYYLLDLYATRPETKTITHRFSLPAEVADNYKGARKYENLIEVKDPDIEKGLNNESGFTPVPPAPPPREMNVVTGERTRLIIFGVAKIHRTRLLATLSGLKLEAEITSLHASLTCRKKSKPASLECSLTGQIGRTMIVLLEGVAPNQQTVVKVTVGKSQALYSSVTRRQKDKNSGLLTVGAVNIDIPQHPVALHGMMTRGSKQLSSTLQELRVTRTSSRMSRGQQQEEADGLPGSPHNYPPAPSIDLEKPQPGPSLLEPIVMQFHIILQSLSITAALLPSLQAQYKMDQVNSSGITGSKAKFTIDLPHHSLSFTTKLQVTEANLPSEASIELPKVHVSAEYIQDGSNSLNDSKIADGVVLRQGSYLSATADIGIFEHSLTTDLLNHLVFVQKVFMKEVNEVVQKVYGGEKPVPLWLEDEEPASSSLKRILFSLVIRIKRIQLTATTPTNSAVRLETGTVELQLSNRVQNVSGAAQPNPYTKLFGKAQVDINLSLGQLLKNVMFEEAEPEFQQFAFFNTRVGLRNAFQEEMAQGADKEVVLITLKRPLIYIQPMAVDKAILVWLNYKNAYEYWNEKRANLNKEVLTATQQVFEKVPFGQLTSQLSSPNLGTLFLQLTVDDMGICVPLNPLPPNNWGMTRGLYDGESRGAVVVTLVNTSISACSSGSLVSKARFVGFCLRFAEDFETSLDDWKPDMNDSSIMNLCVVSEGTYEVCSRTVAQKPDKSDNAKWLLNVQWQMEGVDIHFDVSVGQQLSALGHTLTMLTGSEEDDANISADYDSDDGDQPENGTSQVKKKESILIKKSKNWTDSLPAFVFDPSLDAKKRSKLIEKEMNEQAKIINDLRSLGASHGTIEQEMKRLHELEAMVFKDFRRDMIQKLRRQSVKASGIKGKLGLGNKPNTYRSRSFIVPSPTPEHQLESPEDLNADINSANSASYESSPRSGPSRSASLRVRGLGGPRVTFSDTHTMCRQSSLPSASSDLSLPEGDLEWPETLDIEGEQVELRKKHRDMSCTSSYDSMEGNAPLLDSYGREQTSTTCSPHIAPQKPQEPNIDFELDVKVLINSGKCVLHTKDSAREDELKLLSRMKKERSCSGGNFDFQPSSPSSSKKHLSSKEKSSTTSNSRLRYMQHASVPLVDLTIFHIPGLDVKVHYESKTLPEESISPRTSAENNLLNPLLSSTGLRKPSTKKASLFAWMTLQSIPEETIISPHILEFLEQTLEPIPSKTLAGGGQASTVFPMDNESSSWAATAASGNYVYASFPVDVIVYFHMQPSTFRFSCLPVSRVECMLQLPSLDIVFSSKRAEEEQTEFGDFKSSAESSSTSVKESSAVGGVSVTGCLADFSVYIFHPYGGGKKSSLKEAQWSPLSDSERKDSLSINVEFVKFHLSRSRKINFQSEPMKKSNDASRAVIRFSTIVDVGSASFKYDMRRITEILAFPKAWYRRSIVRRLFLGDLNSGFAYSEGHTAPQMNTEEAVMGSSLLKHHDRHAGDGLSKSAPERSPTLTRDKLRLSFDNDMPRQTRLKDIGRGWSFTSDKGQSASAIKKRESAWETLVLFAVNFTRLNVHMNMGNVMGNVAWMTKDFRSDGRLSIGSTGHKNLYIGIGLGGSSLDAKGGFVGGTIELSKIDTYIHIREEPGTEPDHTLGLKLFALELRLDYMGTSVLMTRVSSLDVTLRDEWKINRSNAGDAFMPTRRPAVIFMHGDLGWDQLQIMISKSTTADLLKMFHKLDEFFSQQFKNSKRVFSSLQTNKNQRVTSNSFKKRGQKKTRGATGAEAAWTMNPTAMSDARHHRHWQRVLAQVAGLQLGSLRFSLPTNGTVLGGTMELHGCNISLACFHGINFKSKSWALFSLKEPCISFATEAQEIPSVESPNTCDVHVVQTLTISLGQQQEQHARHLSMGTVCRLSRSVLFPPQFKSLQEWFHYAFANSEIDETTADGNTSRGRSTSSTSGKLQEHSHTREIIFALPSLQLHLKTEHLQTAKTPDVISEKPLVECSFITEFEDHIFVTVDAEAFFFLHDLISSYHKEKERVYATQGAGASRAYSPDPQDKKRATTITASASTSSATSSTMTEEEKKQSNKQFDPAEIIEPYGIDYILQKLGFSHARTTIPKWIQRGFMDPLDKVLAVLMLRMVMAVREDPSDNNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HMH4</accession>
    <name>A0A8J2HMH4_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similar to Hem: Membrane-associated protein Hem (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS11667</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HEM-1/HEM-2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5103753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HMH4"/>
    <dbReference type="OrthoDB" id="548214at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031209">
        <property type="term" value="C:SCAR complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030031">
        <property type="term" value="P:cell projection assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030866">
        <property type="term" value="P:cortical actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048812">
        <property type="term" value="P:neuron projection morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019137">
        <property type="entry name" value="Nck-associated_protein-1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12093:SF10">
        <property type="entry name" value="MEMBRANE-ASSOCIATED PROTEIN HEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12093">
        <property type="entry name" value="NCK-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09735">
        <property type="entry name" value="Nckap1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00037947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5103753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="1126" mass="128748" checksum="A39D156AC04ECCF0" modified="2022-05-25" version="1">MSRSVLPSQQKLAEKLIILNDRGIGMLTRLYNIKKACDTKSKPPTVLADKSLESSIKLIIRKFPNVDAKGFQTVTNLRNEIVKSLSLYYYTIVDLLDFKDNVCELLTTMDACGVFLDITLNFDLTKAYLDLISTYITLMILLSKWEDRKAVLGLFNIAYEMVNKKSDNTFPRLGQMIVDYDIPLKKLSEEFIPHLNLLRGALNSLWAIYPSRNMTADNWRADQKLSIIGSPGKILKAASTETMSCETLSIDKVEKWIILGFTLCHTVLTQDQSNKLWTSALESGWVLTLFRDEVIYIHQYIQSFFESIKGYSKRISEVKDCYTQAVQKSAYRHREKRKFLRAALKDLGLIMSDQPGLLGPKALLVFMGLSHARDEVLWIIRHGENPPTQGKSKARGNEDLVDRQLPELLFHCEELRALVKKYSQVLQRYYVQYLSGFDAPFLHQIIQNLSGLPEEEGVILSDLCSSMAGLTVKQVEENELFDFRGLRLDWIRLQAYMSVSNCNLSLVDNRELAGFMDTVIFHTKMIDYLDEMLVDTSDLSIYCFYSKVFEEQFHMCLEFPAQNRFIIAYPLICSHFQTSTHQLCPEERHHIHDRSRSIVDMFLNEMAKEAKNIITTICDEQCNMSDRLLPKHCAQLISQAFNRKKKDKNKKNVSEIQKPGVESYRRTREQLTTMDKLHMALTELCHAINYCPAITVWNITFASREYLNQHLEARFSRALVGMVMFNPESSEIAKPSELVVSIRAYMNVLQSVENYVHIDITRIFNNALLQQTQPVDSHGDKTIAALYTQWYSDVLLRRVSGGNICFSANQRAFVSLSAEGAIPFNAEEFTDINELRALAELIGPYGMKMLNETLMWHISSQVQELKKLVVNNREVLIALRTNFDKPEIMIDQFKRLQSVENVLQRFTIIGVILSFRQLAQDALNDVLEEKIPFLLSSIADLRHHLPSDDPMNLVSEMTSAVGLTCKVDPALINALKSQSNDNSNVSDEEEDLIVCLLMVFIAVSIPKLARNENSFYRASLEGHSNNVHCIATAINNIFGALFTICGQNDIEDRMKEFLALASSSLLRLGQENDKDSIKNRESIYLLLNEIVQESPFLTMDLLESCFPYALIRNAYHDVCKVELLQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HMP5</accession>
    <name>A0A8J2HMP5_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Similar to RBM38: RNA-binding protein 38 (Homo sapiens)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HICCMSTLAB_LOCUS13541</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5108905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HMP5"/>
    <dbReference type="OrthoDB" id="4207594at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003730">
        <property type="term" value="F:mRNA 3'-UTR binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12384">
        <property type="entry name" value="RRM_RBM24_RBM38_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000077">
        <property type="entry name" value="RNA-binding motif protein 24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050886">
        <property type="entry name" value="RNA-binding_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48024">
        <property type="entry name" value="GEO13361P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48024:SF56">
        <property type="entry name" value="HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN A0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0221">Differentiation</keyword>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="10">
        <location>
            <begin position="42"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAG5108905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="279" mass="28713" checksum="63EDAA9B0142EE82" modified="2022-05-25" version="1">MLMPGATGLSAVAAGPTGQDELVTSLGALAGVTPQQKDTTWTKLFVGGLPYHTTDKSLREHFNVYGDIEEAVVITDRQTGKSRGYGFVIMGDRPAAERACKDPNPIIDGRKANVNLAILGAKPRGNLQTTFPFAAGIRTGYPTVLPSQYGVPPGYMYQSPYLTAAAPGGLMQLPTTQLSHAAAVAAASQFYEYQNAAAAAAAAAAAASYPGTSSYNFAEAAAYPYTSAAAAANAAAASYVTPYTYATLPGAAALQGATTTGAAFPGLPYQTTPQEARLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HMS0</accession>
    <name>A0A8J2HMS0_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">Cytochrome b-c1 complex subunit 7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HICCMSTLAB_LOCUS10507</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Component of the ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), a multisubunit enzyme composed of 3 respiratory subunits cytochrome b, cytochrome c1 and Rieske protein, 2 core protein subunits, and additional low-molecular weight protein subunits. The complex exists as an obligatory dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with cytochrome c oxidase (complex IV, CIV).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the UQCRB/QCR7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5101605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HMS0"/>
    <dbReference type="OrthoDB" id="425749at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045275">
        <property type="term" value="C:respiratory chain complex III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006122">
        <property type="term" value="P:mitochondrial electron transport, ubiquinol to cytochrome c"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1090.10">
        <property type="entry name" value="Cytochrome b-c1 complex subunit 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003197">
        <property type="entry name" value="QCR7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036544">
        <property type="entry name" value="QCR7_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12022:SF0">
        <property type="entry name" value="CYTOCHROME B-C1 COMPLEX SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12022">
        <property type="entry name" value="UBIQUINOL-CYTOCHROME C REDUCTASE COMPLEX 14 KD PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02271">
        <property type="entry name" value="UCR_14kD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000022">
        <property type="entry name" value="Bc1_14K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81524">
        <property type="entry name" value="14 kDa protein of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0249">Electron transport</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 11" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="4 11" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00038521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR000022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAG5101605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="87" mass="10277" checksum="9222C30F0EE7DA31" modified="2022-05-25" version="1">MAAGGSKVARFLISDGFKKWCYNQSRFNQYGLMHDDCIYESDDVKEALRRLPEDVMDARVFRIVRAMQLSCQKIVLPQEQWTKWEEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HMS2</accession>
    <name>A0A8J2HMS2_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Gustatory receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HICCMSTLAB_LOCUS11864</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Cell membrane</location>
            <topology evidence="1 8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the insect chemoreceptor superfamily. Gustatory receptor (GR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5104162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HMS2"/>
    <dbReference type="OrthoDB" id="6366728at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030425">
        <property type="term" value="C:dendrite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043025">
        <property type="term" value="C:neuronal cell body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007635">
        <property type="term" value="P:chemosensory behavior"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008049">
        <property type="term" value="P:male courtship behavior"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050909">
        <property type="term" value="P:sensory perception of taste"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013604">
        <property type="entry name" value="7TM_chemorcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21143:SF104">
        <property type="entry name" value="GUSTATORY RECEPTOR 8A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21143">
        <property type="entry name" value="INVERTEBRATE GUSTATORY RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08395">
        <property type="entry name" value="7tm_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 8 9" id="KW-0675">Receptor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="91"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="197"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="223"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAG5104162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="303" mass="35194" checksum="EF5406221014D277" modified="2022-05-25" version="1" fragment="single">MYLNAYSLVHQRNLFFEQFIFFKVLGLSPWTLNFSAKASRGRNTKFTVWRFSHITTYTFRQQKMIKIFNKMNNIDQTLQRYAFHSSENGNVIISLIFIFNILICAVLVTLGLHNAVLDMIQKRFKFLNSSIMKLGNIEEDSKLSPAFSLQRLAAQRRPALHDVVNIRHTYHKLCEICEDVSEFYGFTILAGMAHNGILVTLIVSYFLLVFFMGMIKLDLISCFTYGVIVVWFAFQTTVLTSYVTRTIIQIEKTANVINKLIRQCAMDEKVEKELINFRCELAFQKVKFTAWGIFSLDRSFLAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HMT1</accession>
    <name>A0A8J2HMT1_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS12606</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5107152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HMT1"/>
    <dbReference type="OrthoDB" id="6423726at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5107152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="111" mass="13479" checksum="4785691692299B90" modified="2022-05-25" version="1">MGSCFGRCFSNVTDPFTFRLNILFAYKTIYRLFTYIFFPYRYFRHTGSHTHEEEQVELDPCMSQEYDRSSSKKKDMEEYQCLWNLLKILGRKNQINTKDLNHEIMRQLDPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HMV9</accession>
    <name>A0A8J2HMV9_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similar to ATF7IP: Activating transcription factor 7-interacting protein 1 (Gallus gallus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS12637</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5107214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HMV9"/>
    <dbReference type="OrthoDB" id="2434995at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026085">
        <property type="entry name" value="ATF7-int"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056565">
        <property type="entry name" value="Fn3_ATF7IP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23210">
        <property type="entry name" value="ACTIVATING TRANSCRIPTION FACTOR 7 INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23210:SF26">
        <property type="entry name" value="ACTIVATING TRANSCRIPTION FACTOR 7-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16794">
        <property type="entry name" value="fn3_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fibronectin type-III" evidence="1">
        <location>
            <begin position="30"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5107214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="129" mass="14574" checksum="99839D1B2609A136" modified="2022-05-25" version="1">MVVMTQKYKHPAPLPERIVYSDDEILKLPPPVPLLKVSKVSLGIVVSWNMTLDNQYADIESYQLYTYRENTKAPASSMWKKVGDICALKLPMACTLTQLSKGIKYYFAVRAVDKYSRVGPFSQPGEISL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HPN0</accession>
    <name>A0A8J2HPN0_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">WD40 repeat-containing protein SMU1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Smu-1 suppressor of mec-8 and unc-52 protein homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">HICCMSTLAB_LOCUS11975</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subunit">
        <text evidence="12">Component of the spliceosome B complex. Interacts with IK.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus speckle</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the WD repeat SMU1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5104384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HPN0"/>
    <dbReference type="OrthoDB" id="538223at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000082">
        <property type="entry name" value="WD40 repeat-containing protein SMU1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000289">
        <property type="entry name" value="WD40 repeat-containing protein SMU1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006595">
        <property type="entry name" value="CTLH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006594">
        <property type="entry name" value="LisH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045184">
        <property type="entry name" value="SMU1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054532">
        <property type="entry name" value="TPL_SMU1_LisH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22848">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17814">
        <property type="entry name" value="LisH_TPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00668">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00667">
        <property type="entry name" value="LisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50897">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50896">
        <property type="entry name" value="LISH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 13" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="CTLH" evidence="14">
        <location>
            <begin position="40"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="13">
        <location>
            <begin position="210"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="13">
        <location>
            <begin position="260"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="13">
        <location>
            <begin position="303"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="13">
        <location>
            <begin position="345"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="13">
        <location>
            <begin position="477"/>
            <end position="510"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00026184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00046364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CAG5104384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="510" mass="57152" checksum="FC019BCCA9B88060" modified="2022-05-25" version="1">MSIEIESADVIRLIQQYLKESNLVKTLQTLQEETGVSLNTVDSVDGFVADINNGHWDTVLKAIQSLKLPDKKLIDLYEQIVLELIELRELGAARSLLRQTDPMIMMKQQEPERYIHLENLLARSYFDPREAYPDGSTKEKRRAYIANALSGEVSVVPSSRLLALLGQALKWQQHQGLLPPGTTIDLFRGKAAVRDQEDEKYPTQLSKQIKFGQKSHVECARFSPDGQYLVTGSVDGFIEVWNFTTGKIRKDLKYQAQDTFMMMEQAVLSMAFSRDSEMLATGSQDGKIKVWRVQSGQCIRRFEKAHAKGVTCIQFSRDNGQILTASFDATIRIHGLKSGKTLKEFRGHSSFVNEVVFASDGHHVISASSDATVKVWSIKTTECIGTYKSLGAADLTVNSVHVLPRNPEHFVVCNRSNTVVIMNMQGQIVRSFSSGKREGGDFVCTVVSPRGEFIYCVGEDLVLYCFSTSSGKLERTLNIHEKDVIGIAHHPHQNLLCSYSEDGLVKLWKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HR26</accession>
    <name>A0A8J2HR26_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Eukaryotic translation initiation factor 3 subunit H</fullName>
            <shortName evidence="5">eIF3h</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HICCMSTLAB_LOCUS11578</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex. The eIF-3 complex interacts with pix. Interacts with mxt.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the eIF-3 subunit H family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5103575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HR26"/>
    <dbReference type="OrthoDB" id="10265695at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005852">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd08065">
        <property type="entry name" value="MPN_eIF3h"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.10:FF:000045">
        <property type="entry name" value="Eukaryotic translation initiation factor 3 subunit H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03007">
        <property type="entry name" value="eIF3h"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027524">
        <property type="entry name" value="eIF3h"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045810">
        <property type="entry name" value="eIF3h_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000555">
        <property type="entry name" value="JAMM/MPN+_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050242">
        <property type="entry name" value="JAMM_MPN+_peptidase_M67A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10410">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19445">
        <property type="entry name" value="eIF3h_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01398">
        <property type="entry name" value="JAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00232">
        <property type="entry name" value="JAB_MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 5 7" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3 5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MPN" evidence="6">
        <location>
            <begin position="20"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00047068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAG5103575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="336" mass="38576" checksum="E1A075E2F26B17BF" modified="2022-05-25" version="1">MSSRANSRRITELESRIDYVQCDGLAAMKIIKHCHEESTSNMEVAQGALLGLVVQNRLEITNCFPFPKNDELAEEEEYQLAVMRRLRRVNVDHFHVGWYQSADVGNFLSVSLLESQYHYQTSIEESVVVIYDTAKSARGFLTLKAYRLTPQAIQMYKENEFTPEALRTLKIGYENLFVEIPIVIKNSNLTNIMMSELEELIPEEEGTKYLDLGTASVLENQLRCMMDRVDELNQEAIKFNRYQHLVVRQQQDKNRLLAKRAQENAMRAAKDEPPLPDDDINKLMRPLPVPPRLNPMIVAGQINTYSQHISQFCAQSLAKLYITQSLQSAKESKTTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HRA4</accession>
    <name>A0A8J2HRA4_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7">Peptide-methionine (R)-S-oxide reductase</fullName>
            <ecNumber evidence="2 7">1.8.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HICCMSTLAB_LOCUS13156</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Methionine-sulfoxide reductase that specifically reduces methionine (R)-sulfoxide back to methionine. While in many cases methionine oxidation is the result of random oxidation following oxidative stress, methionine oxidation is also a post-translational modification that takes place on specific residues.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>L-methionyl-[protein] + [thioredoxin]-disulfide + H2O = L-methionyl-(R)-S-oxide-[protein] + [thioredoxin]-dithiol</text>
            <dbReference type="Rhea" id="RHEA:24164"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="Rhea" id="RHEA-COMP:12313"/>
            <dbReference type="Rhea" id="RHEA-COMP:12314"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16044"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:45764"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="EC" id="1.8.4.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the MsrB Met sulfoxide reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.8.4.12" evidence="2 7"/>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5108275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HRA4"/>
    <dbReference type="OrthoDB" id="44061at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033743">
        <property type="term" value="F:peptide-methionine (R)-S-oxide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030091">
        <property type="term" value="P:protein repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.150.20:FF:000004">
        <property type="entry name" value="Peptide-methionine (R)-S-oxide reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.150.20">
        <property type="entry name" value="Peptide methionine sulfoxide reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01400">
        <property type="entry name" value="MsrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028427">
        <property type="entry name" value="Met_Sox_Rdtase_MsrB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002579">
        <property type="entry name" value="Met_Sox_Rdtase_MsrB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00357">
        <property type="entry name" value="peptide-methionine (R)-S-oxide reductase MsrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10173">
        <property type="entry name" value="METHIONINE SULFOXIDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10173:SF52">
        <property type="entry name" value="METHIONINE-R-SULFOXIDE REDUCTASE B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01641">
        <property type="entry name" value="SelR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51316">
        <property type="entry name" value="Mss4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51790">
        <property type="entry name" value="MSRB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="MsrB" evidence="8">
        <location>
            <begin position="45"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAG5108275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="175" mass="19902" checksum="8B1CF1877CBD3CAC" modified="2022-05-25" version="1">MNICRNLLQGVVKRPPAVINNNIRNFTVSQIVFNKETKNMSETNKEELKKRLTPIQWHVTQEKGTERPFTGCYNKFYEKGTYTCIVCDQELFSSETKYDSGCGWPAFNQVLDQGKIKLTKDTSHDMVRTEVTCSKCGAHLGHVFNDGPKPTRKRFCINSASISFHEAGEKKSTEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HRQ4</accession>
    <name>A0A8J2HRQ4_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Serine protease HTRA2, mitochondrial</fullName>
            <ecNumber evidence="5">3.4.21.108</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">High temperature requirement protein A2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">HICCMSTLAB_LOCUS12649</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="18">Serine protease that shows proteolytic activity against a non-specific substrate beta-casein. Promotes or induces cell death either by direct binding to and inhibition of BIRC proteins (also called inhibitor of apoptosis proteins, IAPs), leading to an increase in caspase activity, or by a BIRC inhibition-independent, caspase-independent and serine protease activity-dependent mechanism. Can antagonize antiapoptotic activity of th/Diap1 by directly inducing the degradation of th/Diap1.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Cleavage of non-polar aliphatic amino-acids at the P1 position, with a preference for Val, Ile and Met. At the P2 and P3 positions, Arg is selected most strongly with a secondary preference for other hydrophilic residues.</text>
            <dbReference type="EC" id="3.4.21.108"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion intermembrane space</location>
            <topology evidence="3">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the peptidase S1C family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.108" evidence="5"/>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5107238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HRQ4"/>
    <dbReference type="OrthoDB" id="4217619at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043065">
        <property type="term" value="P:positive regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.120:FF:000004">
        <property type="entry name" value="Serine protease HTRA2, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001940">
        <property type="entry name" value="Peptidase_S1C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22939">
        <property type="entry name" value="SERINE PROTEASE FAMILY S1C HTRA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22939:SF129">
        <property type="entry name" value="SERINE PROTEASE HTRA2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13180">
        <property type="entry name" value="PDZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13365">
        <property type="entry name" value="Trypsin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00834">
        <property type="entry name" value="PROTEASES2C"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0645">Protease</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0720">Serine protease</keyword>
    <keyword evidence="12" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="16" id="KW-0865">Zymogen</keyword>
    <feature type="domain" description="PDZ" evidence="19">
        <location>
            <begin position="341"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00016929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00029644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00035606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="CAG5107238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="427" mass="47285" checksum="11A0DC52A5077F7C" modified="2022-05-25" version="1">MASFLYKLLFTTNKNNKFKFIRPISAISQNYSLTHSTKKQYHHDNNHSEASKLIRKFNLTYAVSVGLFGLAYGIYKCSDSDSDSVKNAKKSFDKYYNLLVPKVFAKSDSSNIGDNRSKYNFIADVVQTSLPSVVYIEIKDQTRHDFFTGYPATTSNGSGFIVSEDGLILTNAHVRLQDGSTYTGKVENVDLHTDLATVRINKKNLPVMKLGSSSNIRLGEFVVAIGSPLALSNTITSGIVSGNRQSEELGLDHKHMRYIQTDAPITFGNSGGPLVNLNGEAIGINAMKVTPGISFAIPIDYAKEFLRKVQLHNRDNVGAENNTEHDKRRYVGITMLSLTPDILFQLQQRNSNIPINIRHGVLVWKVILGSPAHTGGLRTGDIITHVNDEPVVEVANIYKAIEKPGALIMTVLRNGETLRLRVEPEDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HSB3</accession>
    <name>A0A8J2HSB3_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Similar to Oaz: Zinc finger protein 423 homolog (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HICCMSTLAB_LOCUS13562</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5108926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10014897at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000446">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000483">
        <property type="entry name" value="Zinc finger protein 423"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000145">
        <property type="entry name" value="Zinc finger protein 574"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24379:SF121">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24379">
        <property type="entry name" value="KRAB AND ZINC FINGER DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="20"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="15"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="102"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="130"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="158"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="186"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="339"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="548"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="693"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="858"/>
            <end position="885"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="891"/>
            <end position="919"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="1230"/>
            <end position="1258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="48"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="203"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="762"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1027"/>
            <end position="1058"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1164"/>
            <end position="1211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1266"/>
            <end position="1285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="65"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="212"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="229"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="786"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1033"/>
            <end position="1058"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="1164"/>
            <end position="1178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1179"/>
            <end position="1211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAG5108926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="1317" mass="148752" checksum="E4030E6D9E23F18B" modified="2022-05-25" version="1">MLFKGNSSRLEFLIEKIQAHKELSPSPLPDDKIFTLRSKEGLMNGSYSWRSEDDSLNGQRGGGTPSSCTTSTSLSFPSETETDVDVKLNGIDSSSTSGLCPYPCQFCDKSFPSLSQLKKHEQTHGDQMPYRCSWCARLFKHKRSRDRHVKLHTGDRRYRCTQCEAAFSRSDHLKIHMKTHDNQKPYHCSECSRGYNTAAALTSHMQTHKRPQSQQLTNFPSKMSENERSSLWPSEGSSPSVSSPLPSSLHKLPPYSPDSSANESSPAVSFLRSSLTLACMYCTKDTFTSMEQLQLHVQAVHELAVSTLSPSSSPNKITDNNYKRRKKKDFNLKIKDELLSCVDSACAMKFTKLNLLNEHIRAHHSNNDKAPINNYDNDTSASATESAFTLSCPLCGLSCSSPAVYAEHYVLEHCENRRVIADKSPEKTNYGKKISNDNSSNLSAGVFSSSTLLCGQCGAALKDFESFRVHLAHHLQVNNYQKQFSVNCPKCELIFTSQDEMVNHLTKHYLSDEKILKHQYWCDACDRHYLDIESLKKHTFEEHTQRLYRCSVCRETFETAVGIQVHLTVKHTRECAVYQCTDCVNNPGFTKGIETVGCDKNRMERDSVFKSSTELMKHVMNAHLSCSSSLALSLSSAKAQDRITQIKGRIGPAAPETTRACGELFLRCCFCGVHCNTEADLQRHLATHSTCLYRCPICRQGFTVEFLLDKHIAQIHNNNSPNATAAIDTGVAATTPAGADTMIDCQNVFNHSKLHDEVRHKRKQLTPELCQQNPSEYKRLTINRPSNNNLNDNDDNSNNNNNNNNEKLKINNCEYCDRKDFTSELELRAHKKLAHKLSIESVGNNLQQQPKSLSQNLESCSYCGELLHSRSELEAHTRIHHSTNELGKRRYKCNICDELFSTGGILAEHKLDKHCKIKLSDVCTVCRVVLHSEVDFIEHVQKHSFEAIDSYQQRHETMASAPVSATTQTISVTNTATNTALISNNSNASITAASTHAPVYCVVCRQTLISEFECQLHARYHLRPQSSVSITDNNNSNSNGINNNNNNNNNNNNNNNNNNNRKELINNIINCCICLREFDNNNSVIPLSNNVTSNERQLNVCNRCYVRHLNGLPILGNNFYNDNDCKVSESFERRNVENNCKLKSIKLECVNEKDDNCNDEEDIDVDVDIDVNNEEEEEKDKGNGEDNENENKHEKEDDSIYNENKNKENKIGVRFENNSHEKNSAGVRPYNCPQCNLEFALKVELEHHLTAVHMNKNMSCMVNATEGRKNNSRKEEEGHSRDANIKDNASEDGLIVKEEIFDTEVEEENCEERIMIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HSC9</accession>
    <name>A0A8J2HSC9_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">CYP302A1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HICCMSTLAB_LOCUS13592</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5108956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HSC9"/>
    <dbReference type="OrthoDB" id="3945418at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050479">
        <property type="entry name" value="CYP11_CYP27_families"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24279">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24279:SF120">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0349">Heme</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG5108956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="275" mass="31572" checksum="BC80576577B73FE8" modified="2022-05-25" version="1">MHLNRSCQRLFGGAKNYSLCTATGFKLNPRPFEDIPGPKSLPIIGTLYKYLPHIGEYNFNKLHKNGFKKLSKYGPLVKEEIVPGVNIVWVFRPEDIAEIFKAEAGKHPERHSHLALLKYRKDRSHVYNSGGLLPTNGSDWWRIRKEFQKALSKPQNIINYISVIDNVVRQFVKLCGDKKYDDLLPLISRLFLELTCLVAFDVSMNSFSIAEMQVDSRSSKLIDAALTTNSAILKLDNGIQLWKYFKTPLYKKLCTSQKLMEEYATESPLSWLIKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HTQ6</accession>
    <name>A0A8J2HTQ6_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Similar to Cactus_Tollpathway_Cc</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HICCMSTLAB_LOCUS13330</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5108624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HTQ6"/>
    <dbReference type="OrthoDB" id="20727at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051059">
        <property type="term" value="F:NF-kappaB binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071356">
        <property type="term" value="P:cellular response to tumor necrosis factor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051070">
        <property type="entry name" value="NF-kappa-B_inhibitor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46680">
        <property type="entry name" value="NF-KAPPA-B INHIBITOR ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46680:SF3">
        <property type="entry name" value="NF-KAPPA-B INHIBITOR CACTUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="162"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="246"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="83"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="340"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="346"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAG5108624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="377" mass="41711" checksum="3A3A093735D71DAF" modified="2022-05-25" version="1" fragment="single">DQDSGTIDSGFISSANLILSSTDLSSENLSSYIDEGQEAVDAPFSKSETAVKDPTAVDSGLDLSICESLSMNLQQVSLNPLQGKNQAQSEPALQPIGNKEDDNVKEKSLPLEVEKWRIFYGQNSDGDTQLHVAIIYGCFEEAAWKLIEMVPHPCLLDIKNIHRQSPLHLSVLTNQMRITRRLILGGANPSIQDGEGNTPLHLACSTGDLSSAYALTEPLSNFERSYLGPHCRIPALPQDLEQRNFKGQMCIHIAAKKDHVDIMRLLLRLGANLEAREGLGGKTALHIAIESNCTSVLNFILEECRPCFETRNYAGMTAYQLAACINQQLANRLVQFGADPKYKDESDSDLSDESEDDEEMYVTELPRHRRQDYGLTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HTU6</accession>
    <name>A0A8J2HTU6_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Similar to Spt6: Transcription elongation factor SPT6 (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HICCMSTLAB_LOCUS13422</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Histone H3-H4 chaperone that plays a role in maintenance of chromatin structure during RNA polymerase II transcription elongation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the SPT6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5108786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="7632775at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008023">
        <property type="term" value="C:transcription elongation factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031491">
        <property type="term" value="F:nucleosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034728">
        <property type="term" value="P:nucleosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140673">
        <property type="term" value="P:transcription elongation-coupled chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00164">
        <property type="entry name" value="S1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09928">
        <property type="entry name" value="SH2_Cterm_SPT6_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09918">
        <property type="entry name" value="SH2_Nterm_SPT6_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.2740:FF:000002">
        <property type="entry name" value="Transcription elongation factor Spt6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.650:FF:000002">
        <property type="entry name" value="Transcription elongation factor spt6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3500.10:FF:000006">
        <property type="entry name" value="Transcription elongation factor spt6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.505.10:FF:000030">
        <property type="entry name" value="Transcription elongation factor spt6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.650">
        <property type="entry name" value="RuvA domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.10">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2740">
        <property type="entry name" value="Spt6, Death-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.850">
        <property type="entry name" value="Spt6, helix-hairpin-helix domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3500.10">
        <property type="entry name" value="Tex N-terminal region-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.140">
        <property type="entry name" value="YqgF/RNase H-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041692">
        <property type="entry name" value="HHH_9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000980">
        <property type="entry name" value="SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028083">
        <property type="entry name" value="Spt6_acidic_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042066">
        <property type="entry name" value="Spt6_death-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032706">
        <property type="entry name" value="Spt6_HHH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028088">
        <property type="entry name" value="Spt6_HTH_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035420">
        <property type="entry name" value="Spt6_SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035018">
        <property type="entry name" value="Spt6_SH2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035019">
        <property type="entry name" value="Spt6_SH2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028231">
        <property type="entry name" value="Spt6_YqgF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055179">
        <property type="entry name" value="Tex-like_central_region"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023323">
        <property type="entry name" value="Tex-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023319">
        <property type="entry name" value="Tex-like_HTH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017072">
        <property type="entry name" value="TF_Spt6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037027">
        <property type="entry name" value="YqgF/RNaseH-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10145">
        <property type="entry name" value="TRANSCRIPTION ELONGATION FACTOR SPT6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10145:SF6">
        <property type="entry name" value="TRANSCRIPTION ELONGATION FACTOR SPT6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14635">
        <property type="entry name" value="HHH_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17674">
        <property type="entry name" value="HHH_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14641">
        <property type="entry name" value="HTH_44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00575">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14633">
        <property type="entry name" value="SH2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14632">
        <property type="entry name" value="SPT6_acidic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22706">
        <property type="entry name" value="Tex_central_region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14639">
        <property type="entry name" value="YqgF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036947">
        <property type="entry name" value="Spt6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00252">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="RuvA domain 2-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55550">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158832">
        <property type="entry name" value="Tex N-terminal region-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50001">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0727">SH2 domain</keyword>
    <keyword evidence="3 5" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="S1 motif" evidence="9">
        <location>
            <begin position="1216"/>
            <end position="1271"/>
        </location>
    </feature>
    <feature type="domain" description="SH2" evidence="8">
        <location>
            <begin position="1313"/>
            <end position="1422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="53"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="124"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="219"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="482"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1284"/>
            <end position="1308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="53"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="71"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="94"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="176"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="231"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="482"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="500"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1284"/>
            <end position="1307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR036947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAG5108786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="1509" mass="174399" checksum="6BBDB849BC127B81" modified="2022-05-25" version="1">MKLITWSILYYYISNWARSIRDVINQLDREAELSDSEEVVNMKIRKRVIISDDEDSSAEEDNNEGVVEGLINDDTEDENESVNTSGDEGRQSSDDDSALEDDDYELLEENLGHKIKRAKRFKRLRRMSADGSDEDEQAEKENIAKSIFEDDADDNKKRPTRQSPSLQSDQEASDSNSEESDDDNFIVDENDQSIKKGLKRKRGVDPALEEAREIFGVDFDYNQFDQNNQKDDDDDGNEEEEEEEGTRKCQRKSTAKTIFEVYEPIELKKAFLTDVDQQIRVKDIPERMQLRSIPIIEVKDKRSHELVEEAKWIYKNAFNNHLLQKVEDKSDSAHKSPKTVGKVRNALELMRCDLLEVPFIAFYRKEFVSPELNINDLWKIFKLDATWCGLRQRKFNLLNLIENMRELQLETVMKESSESLPDDIRVIKDQDIKRVYTIESEEERKDVYNHFMLYYNREIPQLKELLKKKRREAKKLEKLAKLKQRGEEAEENGEKSPAESAEEEKEEEDSLKQAVRSGPYSIYRRAGLCSFAKKFGLTPEHFAENVRDSYQRHEVEQDPVEPSVIAQNYLGANFETTEQVLKAVQHMVAIQLAREPLLRKCARELYTERAKITVRPTKNGIKVIDESHQLYSVKYLKDKPVRDLVDHIWLKLLAAETDGLVTITFSDTVEGTLGSDFIIEFSQLYIKDEFSNNVQEWNDLRRASVKMALRNYIIPDLKNELKTKMTVEAKEAIMYACCQKLDDWIKFQPYTCTLPEEFEEDYEWSTKDGFRSIGIAYVPDSQEAAYASAVLPTGTCYNFLKMLHLLKRIDSFNQQEKLLKEADMLALKNFIEKCKPHVIVVTAESKEALMICNDVKKCLKELTKTNKFPSIQVELCDPNVAKIYSTSNRGITELPSYPPILRVATSLARRILNPLGEFAQLCNADQDLLCLRFHTLQDLLNKEELLTELYYQFVNRVNEVGVDVNNESSCTGSLLQFISGLGPRKAQNMLKLLKHKHLILNNRTELVHKLHFGPTVFINCVGFIKIDGSVITNRSDVYQEPLDETRIHPESYEWANKMAIDALEDKDQDMDQFTATERIMKTSYLLDELDLEAFAEQLKKLGFSEKLTTLLDIKEELKHPYKDMRRPYLSLSAKEIFNLLTKETPETFYVGKLVQATVVGFHYKKPKGEQLDQSNPIKDSETGTWQCPFCLSKDFLELSEVWSHFDSNKCPGKAVGVRLRLENGLSGYIHLKNLSSQSVGNPEDKVRISQMISCRVLKVDVEKFGSECSSKSSDLADVNNIFRPAKDPHYDHQAEEEDKRVEKESQNKSKNNVYARRVIVHPSFHNITFAEAEKMMQTMDPGECVIRPSSKGVNRLSITWKIVDDIYQHIDVVEEDKPNAYSLGRSLYIGAEKFDDLDEIIARYINVMAGYVAEVLKFKYYCDDVYGVKHKAEEILRGQKKINPKGIPYILSAAKTHPGKFVLSYIPRSTCYHEYFSVTTEGFKFRNRIFINLEAMINCHNNRYTLVYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MD78</accession>
    <name>A0A8J2MD78_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Olfactory receptor 200</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS4079</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5084335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MD78"/>
    <dbReference type="OrthoDB" id="7179992at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0675">Receptor</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="133"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="173"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5084335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="198" mass="22753" checksum="9B574CA64FE34F49" modified="2022-05-25" version="1" fragment="single">MKLSTESRGFRITPEKAVKFIKVSVYLTCMWPPQGDESKISFKFRKYLSVFLSFGLFFPLLFSIVIYFNDMLIILKSAICMTALVNYISKVIIVTRYHREFEKFRSVLNEFILKASDSSKVVFQKYVDKFWKFQFFMVFCYYFGATGIIMGPLVLPQKFPTDAVYPFSVENPVVAGIIYAHQGFAAYLGAAGMVLDGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MFQ9</accession>
    <name>A0A8J2MFQ9_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS4896</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5088567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MFQ9"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47771:SF3">
        <property type="entry name" value="LD27203P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47771">
        <property type="entry name" value="LD27203P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="287"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="294"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5088567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="326" mass="37669" checksum="63686DCC447A51FA" modified="2022-05-25" version="1">MSTGFEGYEGHSHEDHYPHHHHEEHKVKEIVIEKKVKVPYPVEKKVHYPVEKEVPYPVEKKVPVPYAVEKKIPVPYKVYVKVPVHIPAPYPVEKKVHYPVHVPVERPVPYKVYVPAPYPVEKKVHYPVKVPVPQPFPVEKHIPVPVKVHVPYPQPYPVEKKIPVPVKVHVDRPVPVPVIKPYPVPVEKKVPYPVEHPVPYPVKVHVERPVPYTVEKKVPYPVKVPVPAPYPVEKKVPVPVEKPVPYPVKVPYDRPVPVHVTKHVPYEVTKHVPYPVKVPVPYKVEHHEHHEHHEHHEAEHGHDFGGHDFGEHGDFGGHNFESHHGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MFS1</accession>
    <name>A0A8J2MFS1_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS2531</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001117">
        <property type="protein sequence ID" value="CAG5077684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MFS1"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="106"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5077684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="143" mass="15489" checksum="A9F18C0BE49E1B6B" modified="2022-05-25" version="1">MFAEASKRLLPLHLSSCDSADARKRRRLCPTSRRRAIQGVRDVERGHPAAKPSFLRVHPARRVSTLPSLGRRCSFSTTLAAAINRPTMLTMSTLMMPTTITTITNPGPISTASVPQKSENKLTTTASLSHPASAVNSKSGAYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MGI7</accession>
    <name>A0A8J2MGI7_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Similar to Wasl: Neural Wiskott-Aldrich syndrome protein (Rattus norvegicus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HICCMSTLAB_LOCUS3182</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5081056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MGI7"/>
    <dbReference type="OrthoDB" id="8963340at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00132">
        <property type="entry name" value="CRIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01205">
        <property type="entry name" value="EVH1_WASP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000130">
        <property type="entry name" value="neural Wiskott-Aldrich syndrome protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.280.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.810.10">
        <property type="entry name" value="CRIB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000095">
        <property type="entry name" value="CRIB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036936">
        <property type="entry name" value="CRIB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011026">
        <property type="entry name" value="WAS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033927">
        <property type="entry name" value="WASPfam_EVH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000697">
        <property type="entry name" value="WH1/EVH1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003124">
        <property type="entry name" value="WH2_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11202:SF36">
        <property type="entry name" value="ACTIN NUCLEATION-PROMOTING FACTOR WASL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11202">
        <property type="entry name" value="SPROUTY-RELATED, EVH1 DOMAIN-CONTAINING PROTEIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00786">
        <property type="entry name" value="PBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00568">
        <property type="entry name" value="WH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02205">
        <property type="entry name" value="WH2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00461">
        <property type="entry name" value="WH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00246">
        <property type="entry name" value="WH2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47912">
        <property type="entry name" value="Wiscott-Aldrich syndrome protein, WASP, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50108">
        <property type="entry name" value="CRIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50229">
        <property type="entry name" value="WH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51082">
        <property type="entry name" value="WH2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="WH1" evidence="10">
        <location>
            <begin position="26"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="CRIB" evidence="9">
        <location>
            <begin position="217"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="WH2" evidence="11">
        <location>
            <begin position="447"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="domain" description="WH2" evidence="11">
        <location>
            <begin position="477"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="290"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="526"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="303"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="323"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="340"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="364"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="389"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="404"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="420"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="462"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="526"/>
            <end position="538"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAG5081056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="546" mass="59580" checksum="7055ED82B2580D8A" modified="2022-05-25" version="1">MKSTGAKEHRGCVLLKPEENEEIFRLIGNRCQCLAAGVIQLYLTELPDHREWIKKNTGIITLIRDNPKRSYFLRLYCPQRKAMLWEQELYNSMDYNAPLTYFHTFEGEECMVAFNFANETEAVIMRNIILERLNSNKQRRQERKTRIETDTQQKVVTLPRRSPNSSTNFFSSTTSVNMMNGSSSSVSVNGGLSGSAMYLRKKKRKKDHKRKLTVADISQPSNFRHVVHLGSDTSKCIDPESIDPTLRKFFDVAGVTKQQLTSRETRDFIYDFILGHGGITAVKNELGLTSTSVPTSADNNHHPLPPPPPTADNPPPIPARTVPVTSSPGINNNQSRTTRPLPPARTNVPPPPPSAPPAHRTLPSRPPPPAGSPALPPPPPAVPPPPPRSSSSISNVSNSSGSAPAPPPPPPPPPPLPELNADNSPASNFNSSSSSISGNNNGEFNDLRPKLMDAIRSGTTLKKVEQTEKKTTPVMDSRSDLLNQIRQGVELKPVVNEPKPASIGVAQGGLASALSAALAERSRLLGYTGDSQDSSSGTSDDDEWDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MGM1</accession>
    <name>A0A8J2MGM1_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Similar to UPP1: Uridine phosphorylase 1 (Homo sapiens)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HICCMSTLAB_LOCUS5608</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PNP/UDP phosphorylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5090380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MGM1"/>
    <dbReference type="OrthoDB" id="204058at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004850">
        <property type="term" value="F:uridine phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009166">
        <property type="term" value="P:nucleotide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006218">
        <property type="term" value="P:uridine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17763">
        <property type="entry name" value="UP_hUPP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="entry name" value="Nucleoside phosphorylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000845">
        <property type="entry name" value="Nucleoside_phosphorylase_d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010059">
        <property type="entry name" value="Uridine_phosphorylase_euk"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01719">
        <property type="entry name" value="euk_UDPppase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43691:SF11">
        <property type="entry name" value="FI09636P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43691">
        <property type="entry name" value="URIDINE PHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01048">
        <property type="entry name" value="PNP_UDP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="Purine and uridine phosphorylases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nucleoside phosphorylase" evidence="3">
        <location>
            <begin position="88"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="129"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="173"/>
            <end position="176"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="252"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="254"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR610059-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG5090380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="375" mass="42081" checksum="E3F0E676E969A4E9" modified="2022-05-25" version="1">MPTCTCENLSQDELINHVCQIKILSDCESDSDENEFGGLKKLESSVRYSDGSVRLRNPNIELMDQDILYHLALGSGSHDLVEMFGDIKFVCMGGTPKRMENFANFIMKEIGHKLPTGTTLLDISQYSYRYSMYKVGPVLSISHGMGIPSVGILLHEVIKLMYHAKVRDPIFIRIGTCGGIGLEGGTVVISEEAVDGMLKSYYEVPILGKMVRRPAKLDKQLVKELNAMAHPEDPYDTVIGKTMCTHDFYEGQGRLDGAFCEFTENDKMEYLQKLQKAGVVNIEMEAVAFAALTHHAGIRSAIVCVTLLDRLKGDQLMAPKEVLEEWQKRPQILVSRYITKYLQTKGRLSLEGHGSMAVKSPRRFKLVQQESENYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MH97</accession>
    <name>A0A8J2MH97_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS6062</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5092336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MH97"/>
    <dbReference type="OrthoDB" id="8119066at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="24"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5092336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="239" mass="27268" checksum="8A341D41A897F49A" modified="2022-05-25" version="1">MVAELRVDVRESSQHHNDLKSEQITMLKMASLVVLITIIAVFFQGNEAYAIRTEQNQGQKQNLEDDYQDAEPTQNLSRDGSLLLPAINEPLPGSVFGLSMPQDASIVHLVLNLDNSTAKRIGKLIRGFTTFQQSFDRTVHLTNPFLTLNEIDPLKQKSARNDFVRQTKEIKWVSAVASHRMKLVKLYEELSFMCNYLKTNSEISIQEIATVREKEKDLQFKKQQANTLTWSSVEDTLIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MHW7</accession>
    <name>A0A8J2MHW7_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PGRP.6_Cc</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS3490</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5082215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MHW7"/>
    <dbReference type="OrthoDB" id="7695627at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="283"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="14"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="89"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="116"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5082215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="322" mass="36256" checksum="F0A20343560EF76E" modified="2022-05-25" version="1">MVTRQPEEFRRNNDQQIGWIDNQNQNNNNVKENERRCGNNDKFNIRSESVVVIEDNDLDIDVENGDDNNINLNIETTRPSYRCSSTGESSNESSLNSNYSDSNDNDNDNDNDNDKSSNQSSFNNDHAINIDKYDDRIFYDDEDYEESGDQDKEEDDVEEAEKAIGEMGGWADLKGAQMQKIQHETITGHVLPTLDTTAFGDICIKGSSNVRVGNTTLYKGPVTIKQFLYTNSGDGNGQPKDFINNQTSDANILTTDGSTLPIIPVQQENLIVRKLLWTWRCTALFSFITLIAVLIIVVVSLKLTEKLDDYPSYKPAIDPDGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MIP1</accession>
    <name>A0A8J2MIP1_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Target of rapamycin complex subunit lst8</fullName>
            <shortName evidence="7">TORC subunit lst8</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HICCMSTLAB_LOCUS4732</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Subunit of TORC1 and TORC2, which regulate cell growth and survival in response to nutrient and hormonal signals.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Part of TORC1 complex. Part of the TORC2 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the WD repeat LST8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5088149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MIP1"/>
    <dbReference type="OrthoDB" id="400at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031931">
        <property type="term" value="C:TORC1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031932">
        <property type="term" value="C:TORC2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051897">
        <property type="term" value="P:positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032956">
        <property type="term" value="P:regulation of actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032535">
        <property type="term" value="P:regulation of cellular component size"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038203">
        <property type="term" value="P:TORC2 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000505">
        <property type="entry name" value="Blast:Protein LST8 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037588">
        <property type="entry name" value="MLST8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19842">
        <property type="entry name" value="G BETA-LIKE PROTEIN GBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19842:SF0">
        <property type="entry name" value="TARGET OF RAPAMYCIN COMPLEX SUBUNIT LST8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 6 7" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="11"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="77"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="120"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="212"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="262"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU369068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG5088149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="314" mass="34968" checksum="2671E5EB8E8F321E" modified="2022-05-25" version="1">MTVEESDQVIFVTGGYDHTIKVWQAHTGVCQRTLQHTVSQVNALEISPNKHTVAAAGYQNIFMQDLAASNNSIALNYEGASKNITSLGFQEDGKWMFTGSEDCSARIWDIRSGTFQCQRIFQASSPVNCVCLHPNQSQLIVGDQSGIIHLWDLRSDRNEQLIPEAEASIQDVCINTEGTYMAAVNNKGSCYVWTLTGGIDEEITKLHPHQKLAAHERYALKCKFSPDSTLLVTTSADQTARLWKTSDFSPSIVLQHESKRWVWDAAFSADSQYIFTASSDGIARLWNVNTGTIEREYQGHQKALTALAFQDQVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MIV2</accession>
    <name>A0A8J2MIV2_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Neurite outgrowth-associated protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS4853</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5088457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MIV2"/>
    <dbReference type="OrthoDB" id="6415470at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010487">
        <property type="entry name" value="NGRN/Rrg9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13475">
        <property type="entry name" value="NEUGRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13475:SF3">
        <property type="entry name" value="NEUGRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06413">
        <property type="entry name" value="Neugrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5088457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="412" mass="48077" checksum="D47376524BCC2C57" modified="2022-05-25" version="1">MNQLKNLMYICKRGYKSRGPQRISIPKILRDVGDSKTERTLYPDIKDTDIKIDEDYTDPDFNEPDFTLAHKSYDEHMRESYVEKQKLKGRIVAQKLFKSDDPNFVTWAERELMRKLHLKDSDEWSPEQLSESFPALPRTIKKLLKSKWLPRSTESVVNYDEKVVENWNQFKAGNLNLDPQLAKHLEKFKGRKINAEELKKIAENFVRPPRVFPKPKSKFFTSIVQDYIEATKDKDDNDPPKITDGKNKIKKKSIVDMTLFLSSNKFNKKEKYKTYDKFLEENVSDVVGKQNLNLEEQLLVNEYKEQKNRASVSDRSITHVSVENEESSVEVSNKPAEVQVTNVPVPKFDINESSMETGILEWKKKELGTDDNHPRFIKVPRKKANSGVTFKVKDCYYDSDGEFMYKIPGLRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MJ87</accession>
    <name>A0A8J2MJ87_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to cep131: Centrosomal protein of 131 kDa (Danio rerio)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS5245</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5089456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MJ87"/>
    <dbReference type="OrthoDB" id="197735at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034451">
        <property type="term" value="C:centriolar satellite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035735">
        <property type="term" value="P:intraciliary transport involved in cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010824">
        <property type="term" value="P:regulation of centrosome duplication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030465">
        <property type="entry name" value="CEP131"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31540">
        <property type="entry name" value="CENTROSOMAL PROTEIN OF 131 KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31540:SF1">
        <property type="entry name" value="CENTROSOMAL PROTEIN OF 131 KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="166"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="328"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="463"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="8"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="26"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5089456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="628" mass="73746" checksum="7B0969313E39C13C" modified="2022-05-25" version="1">MINIVHQKVTSKPPISQKFTKSPRNAGERERSSEKKTKEEIKDCNQNIIETDSCSLDQLCSMISDLEQSLVQEVVAVETCTLPAENPAAFIDLDHMIDKEDCGFSGTSASTYDDIMSFLGTLEQDCPVGDFESSPRPEKLPEEIYQLQSLIKNPNQALSDKTKDDLATALLQLEDREATLKLLKEELKNERKAACDKLDSQRKAHVTELQTQKTKYQNIIRRHQKFVEQLIEEKKQLSDKCNNLAINIKDMEIKYQKESKLAMDKHAVEIQRVKEMCLAGEKVRRERWLEAKKNKIKESTVKGLEPELRNMIDAHQKEVLEIRSVHMKELQDVELRAIRRANQQLEELRKFFEDLQLEKKKFAEELERRDTERDAELQRVIKQSQAKVEKLTTEFEVDRKKLRVDLEAEREAWVENFKKQQSSKFEMAEARVRDECNRERDRQIELAIARIEKETREVKVSLQKSAESKLKSLREKYEAELEVARESERIVREKLEVCEGKVDGLEKELRRVECKLSKCSVELQDLRKSEEKLTEERDHAKKIARMEIEKEKKVLEDKNDELYREIERINCNRDSNLAQLYSRIRLIVTQKDVAIKSLRRECDEARNKCDHLEKLIDQQRKEYVLKTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MJH6</accession>
    <name>A0A8J2MJH6_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS2686</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001117">
        <property type="protein sequence ID" value="CAG5078245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MJH6"/>
    <dbReference type="OrthoDB" id="7679112at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012464">
        <property type="entry name" value="DUF1676"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21879">
        <property type="entry name" value="FI03362P-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21879:SF26">
        <property type="entry name" value="OSIRIS 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07898">
        <property type="entry name" value="DUF1676"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="195"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5078245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="307" mass="34905" checksum="DD67B3A2B289FF6F" modified="2022-05-25" version="1">MKTDGAKKYFPSPKLPKLLLSSLLELKLPRTIKRVSSIIFTLTVLANTVAAEYVNETISSDFVSRCRRDCVIKRDVVVCGKYRVARWLNDVREKDFSYGPIKFIRIPAVTEEPILPKVPAKKAYKFGVTETLNFLRDTAEEIIKRRALVYTFQPALSSGRSFSNAPIVLDEDELVQMQKGGKDNSRLFHKKKKAIILPVLILLNLLKIKLILIPIFLGVHLIKKLIIIGGLFVPGFLSKLRICKVPHHGFTFPFHWGTAAEAPVDYPSGYGNEDPGWSHRNDIYPGLPGYPAPYHYPPAYYRQRRQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MKV0</accession>
    <name>A0A8J2MKV0_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transposase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS5686</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5090584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MKV0"/>
    <dbReference type="OrthoDB" id="8184047at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579">
        <property type="entry name" value="F5/8 TYPE C DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579:SF1">
        <property type="entry name" value="F5_8 TYPE C DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="129"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5090584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="832" mass="96916" checksum="CBB442B8C95BFE0F" modified="2022-05-25" version="1">MSRKPMRNLVSHRQYIARLRPIINQINREVAGDVQLEDNQAQINNYQNNIDYQNVEDQDLPIENQVPLQPNDDEPPEIFPDFEEFYEWAQQNNEADNGLIDELLPNRYPGFNNGHQNQYLQNENNIFEIPIRRNDNSDDEDEERPEQIHDDDNNPLYLGAEITKRESMLVILAMCLKHHLSMTCIDDLIRVIELHCLSRGLIKNNKENVKKHFYCPSCASQLNNENEICYMCPQTESTFFLELPIIDHLKEMYKSENFFNSLQERFNRPNINNNITDIFDGELYKTWTENGFLSNPNNISFTWYTDGVPVFKSSKISIWPIYLTISELPFEERKKIFNTLLLGLWYGDKKPHFNSFFYAFRPVFESLLLNGIKVVCPGENEITVRAALLMGVCDLPAKIDSLNFVNFNSKYGCPVCFFEGRVMQIGPRSYLQVYPYSNTFQLRSSRICEDLARQATPDNPQFGIKGPTSLAKLMPDFMSGMCIDRMHAVDGGVIKKILNLVFNISYRNEPFSLYTHKDTINNRLQLIKPPKFIHRMPRTTDDLIHWKASELKMAVFEGIMRADYLNHYLLLMVSMYFLSADEISELMITTAEDFLYRFVREFQQLYGEKFSSINIHLLLHLPKCVRLHGPLWAHHCYEYESFNGEILLHIHGTRHIGSQVSSGHGHLIRMITDVEQIPNESYVRMYIALEHKILQEIPDIIISAMNNSGIVRNGEYTRAMKTSTSVVKYLDAGTEQVGRILCFIKYLHCQCLRNNCTCNFKYYAIIQKLIRTNSHIIDGDNFQIDSSNIFYKCSETNIYQAIDVNNLLTPCIFINMNNQSHIIYPLNTKELE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MMW7</accession>
    <name>A0A8J2MMW7_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CHK kinase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS4160</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5084631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MMW7"/>
    <dbReference type="OrthoDB" id="8250698at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015897">
        <property type="entry name" value="CHK_kinase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004119">
        <property type="entry name" value="EcKL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11012:SF56">
        <property type="entry name" value="CHK KINASE-LIKE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11012">
        <property type="entry name" value="PROTEIN KINASE-LIKE DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02958">
        <property type="entry name" value="EcKL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00587">
        <property type="entry name" value="CHK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CHK kinase-like" evidence="1">
        <location>
            <begin position="128"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5084631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="403" mass="46209" checksum="71C4BB935930C1CA" modified="2022-05-25" version="1">MTKPAWLTAEFIERILRDADKDYSISVTNIEVKLATSKGDNYCSEMYRVYFDLTRDDVGKRVSKNGTILVKVASTDQQIHKELIEDINIVDNEIKMMTCTLKDMESVLKDTKLSGRCYYTQRSNPPVLVLEDLAPLGFRMADRQNGLDLCHSVLAIRRLAKFHASSVFVIEKKPKVKKLYSKGLFDTRCPPELSKLFVNGVKAMTKVAESWSEVSEQCVEKLKSLQNSAYSKACEIGMLREDEFNVINHGDFWVNNMMFKYDDKGNVIDHIFVDFQICVYGTPALDLQYYLNTSPREEVLIYNKNLLIEEYQKTLSLTMKKIGCKTCAPSLEYVKKMLLEREFLGFVVASVSLPIMIVDRDHAQGLDELASDGEFSPKAYSNEAYKIKMVRRLKEWNDLGIFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MNH4</accession>
    <name>A0A8J2MNH4_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BED-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS8457</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5096931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MNH4"/>
    <dbReference type="OrthoDB" id="7683164at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140996">
        <property type="entry name" value="Hermes dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5096931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="324" mass="37062" checksum="95D777A29BFC10C0" modified="2022-05-25" version="1">MQRGGRPKHSFWEEGGFQRIRENGKQVASCVKCKKIINNTAEQRLKSHRNRSGSYDDNNNSDLKRGSYDEAATPSSSIQLKKEKRKISSFLDSISDKEHLKIDEALSNFFYSNNLSFDLIQDPYFKKFCKILRPAYEVPSEVKLSTTLLEKAHDKFTDRKVNLKEKKGTLLFCKNVAQTNGLEINAITKTGNDTLFLKSWILEEERDYISNYLQMINESSSIALKKYYISVYAVISFINIPKNNRILDSTSASPLLSESISMWHFDCHLETVDTLIAAIHDDSLEIKINRLLNAIKSTDIEEELVKRGGDTLSCQTRCSAFILF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MPJ0</accession>
    <name>A0A8J2MPJ0_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS9697</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5100624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MPJ0"/>
    <dbReference type="OrthoDB" id="7667520at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5100624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="179" mass="21129" checksum="5A4B6A1E9BF3866E" modified="2022-05-25" version="1">MDFSLQKQPRKLEIMSPDLVLEAAFDRGNVNSRHAMYIISVTLKSARFDIKTVIVSFNTIHRKRAFHVTEIELEKLLERKLIWFPCHHYIWEIVLKGVFKVFWPTQSGPNVQIFTRFKNSWDKITLDNSKWQSGMTDAVVAITIEDNAVDLLVFFKSYLQMKYNFSYDLGVFVKFQNRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MPU6</accession>
    <name>A0A8J2MPU6_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS4825</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5088398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MPU6"/>
    <dbReference type="OrthoDB" id="7989680at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5088398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="135" mass="16148" checksum="B99042C6ABF3FB07" modified="2022-05-25" version="1">MEKIRVLDRKCIRTCLRVYRSRESNFKKQISNETLYNIANIPRIDNFIIKLTRDYFAKFSSIENKEIEKILETPDQQIYITNHNSACLPPQAFIYFDKKGIIQDSNNVPTYSTNKNLYPNWIPLNTYLINKIFRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MQ08</accession>
    <name>A0A8J2MQ08_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Similar to lamp5: Lysosome-associated membrane glycoprotein 5 (Xenopus tropicalis)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HICCMSTLAB_LOCUS9850</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endosome membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Membrane</location>
            <topology evidence="8">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the LAMP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5100777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MQ08"/>
    <dbReference type="OrthoDB" id="6248302at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072594">
        <property type="term" value="P:establishment of protein localization to organelle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048528">
        <property type="entry name" value="Lamp2-like_luminal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002000">
        <property type="entry name" value="Lysosome-assoc_membr_glycop"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11506">
        <property type="entry name" value="LYSOSOME-ASSOCIATED MEMBRANE GLYCOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11506:SF40">
        <property type="entry name" value="LYSOSOME-ASSOCIATED MEMBRANE GLYCOPROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01299">
        <property type="entry name" value="Lamp2-like_luminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51407">
        <property type="entry name" value="LAMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0967">Endosome</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="280"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="Lysosome-associated membrane glycoprotein 2-like luminal" evidence="10">
        <location>
            <begin position="108"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAG5100777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="314" mass="35068" checksum="FCBE52CE6F266AB4" modified="2022-05-25" version="1">MNPWNDETEKRQTEFRCILTTAFSSPSTPAISRKVMDEIYTTARPIKTIVELNTFRPLSKQIANNLKTTSVETTTTTTVATKTTTKTVSTPRTFNGNEPLYRLDGVTGQACILLQVDALITVKFRTKLGEEQEANIYVPSDATVTGNCDSENFVTMSLKWNAFVLSWSFAKTPGGERWYVDKVELTYNSSDRHFPLIDQPNKTIRLTSGQKNTLFPTPVGKSYVCEEEVSIPLSDGKNNAALLLRDMKLQPFKFKNNEFAVEFSCKSLSARAGRDETAPVAVGSTLAAAVLLTITGYAGWRYFKVKKVKYDTME</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MQ48</accession>
    <name>A0A8J2MQ48_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS11223</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5102866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MQ48"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="135"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="196"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5102866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="240" mass="27027" checksum="C581926B8226D8F7" modified="2022-05-25" version="1" fragment="single">STIDVGTIINISPWQEMLSHGDKESRQTCLSYFSPPECAILGKEAILKDLERDREDGNEEETDTIGIFAFPTINLTHLVTNLTEKPKPPHLLTNIAEEPVGENTLLSPWGDSLEGNENRLTRIGLHHQEESKHRYITIANTGAVLSIITSLALFFGYYYYGCCCNCLQPLQKFKTRKQKSFQGKTNETFELTDTISMYPTRPGSPRPAKHQQSLPGVHGQQKITPTPSRTSIRLADYDYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MQY4</accession>
    <name>A0A8J2MQY4_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cc_odve66_11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS10724</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5101856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MQY4"/>
    <dbReference type="OrthoDB" id="7684004at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035211427" evidence="1">
        <location>
            <begin position="25"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5101856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="287" mass="34171" checksum="467F9D1FFE010622" modified="2022-05-25" version="1">MMIILPLALVAYILMLVAMSITSACTNSFNYNESIKHTQNKNETDAPIPIISSTVKNIERKNISRIAIIQKIQEAIKANNRMFPECHDQEIGEYIKDTKSFLNKKFERWNEDDVEDFRYYCDCGVNKLQMYAKYCDKTDMDAATDMIYHVDDKILRYFDYKRAEEQSFFYWDFAICFTRLLICYEYLGDDELVDNKLICHTVVNRLTNALNNDFYSTEDWMSHNAKKIVYLNISYLLTNYLYSKNKFEAMIDNDAINLIKRFIPLLQDQQYKHFYLDSFRALEMHNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MRJ2</accession>
    <name>A0A8J2MRJ2_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Histone-lysine N-methyltransferase Suv4-20</fullName>
            <ecNumber evidence="3">2.1.1.362</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">HICCMSTLAB_LOCUS11647</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>N(6),N(6)-dimethyl-L-lysyl(20)-[histone H4] + S-adenosyl-L-methionine = N(6),N(6),N(6)-trimethyl-L-lysyl(20)-[histone H4] + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:61992"/>
            <dbReference type="Rhea" id="RHEA-COMP:15556"/>
            <dbReference type="Rhea" id="RHEA-COMP:15998"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61961"/>
            <dbReference type="ChEBI" id="CHEBI:61976"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>N(6)-methyl-L-lysyl(20)-[histone H4] + S-adenosyl-L-methionine = N(6),N(6)-dimethyl-L-lysyl(20)-[histone H4] + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:60348"/>
            <dbReference type="Rhea" id="RHEA-COMP:15555"/>
            <dbReference type="Rhea" id="RHEA-COMP:15556"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61929"/>
            <dbReference type="ChEBI" id="CHEBI:61976"/>
            <dbReference type="EC" id="2.1.1.362"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.362" evidence="3"/>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5103713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MRJ2"/>
    <dbReference type="OrthoDB" id="6627536at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140941">
        <property type="term" value="F:histone H4K20me methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19186">
        <property type="entry name" value="SET_Suv4-20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.1700:FF:000001">
        <property type="entry name" value="Histone-lysine N-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.270.10:FF:000006">
        <property type="entry name" value="Histone-lysine N-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1700">
        <property type="entry name" value="Histone-lysine N-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041938">
        <property type="entry name" value="Hist-Lys_N-MTase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039977">
        <property type="entry name" value="Suv4-20/Set9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025790">
        <property type="entry name" value="Suv4-20_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044426">
        <property type="entry name" value="Suv4-20_SET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12977:SF4">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE KMT5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12977">
        <property type="entry name" value="SUPPRESSOR OF VARIEGATION 4-20-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51570">
        <property type="entry name" value="SAM_MT43_SUVAR420_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0678">Repressor</keyword>
    <keyword evidence="8" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="11" id="KW-0804">Transcription</keyword>
    <keyword evidence="10" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SET" evidence="17">
        <location>
            <begin position="144"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="369"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="519"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="558"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="674"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="723"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="959"/>
            <end position="1006"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1049"/>
            <end position="1081"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="369"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="405"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="415"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="16">
        <location>
            <begin position="446"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="467"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="527"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="584"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="678"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="747"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="779"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="16">
        <location>
            <begin position="800"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="959"/>
            <end position="969"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="16">
        <location>
            <begin position="1052"/>
            <end position="1069"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00051837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00052814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00071597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="CAG5103713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="1100" mass="122462" checksum="5AFB6450C8580163" modified="2022-05-25" version="1">MVVDSLSVQGSAAARKQERRLGGSVGNKMQPNGVSGGTGGMTPKELCDNDDLATSLVLDPYLGFVSHKMNIRYRPLKANKDELRKVITDFMQTQNYEKTYKKLMGSDWGARLPHAKSKQQQLNLQKHVYRYLRIFDKDSGFAIEPCYRYSLEGQKGAKICATRKWLKHDKIPCLVGCIAELSEKEEAALLHPGKNDFSVMFSCRKNCAQLWLGPAAYINHDCRANCKFVATGRDTACVKVLRDIEVGEEITCFYGEDFFGDGNCYCECETCERRGTGAFASQKPGDELSTGYRLRETDNRINRTKHRQQPIGSSKHHADGALTEKNAVLVGNAAVAPQSLSMKELRRKGLTKYDAELLIAQGCRFSDITQQQPTIPEDTTNTQSLQAPRPHPSSIIGPGTRTLRNKQQTTKNESNNNNNNNTNNNNNNNNNNNVNVNNGQSLRASRLQKRTATKRNRASIDERSIHHTGSNKNNSEYDGTAIDCLAEESKENPPGSLNNNLNNDNTKLHTCSVLTKASNNETDEFNDNSVPSAKIDNNSSEKSYNNVHGLPAAVAVESKKNNSPDSGVSEQIQDKDSKLLHPNNLKQANNATSTAERWRNSHTSFTGMTRRRKSLLQSSGDSRDIEHRKSPALGETPRKTNYSEGEGQTERYLQIDAKVAPAESEFTDRQFDSTMQASKNSNSGISSSSSTRAAKANDETTARACVGEHARFGDNIITGDDKLSKKETVEDVQEFDSGYSEGSQSNKSDEDFNKWKDQSSGKKSEDTRSLTLKRPFVESSSSSSSSFSSSYSVTVEKASPRSRRKSKRGSRSGGVKTRKAKDSVSVADKERVKKVRSGRVVRTNGRLTRSSRREECLKEETGESTVVGAADDDSGIQGDIYEFNDNESSISDTIDIIRRKNIDSRVTDNSNIKLSESLKNNELSGKNEPPVLIREEPWPAKQPVLTTNVDDVQLINNTNDTVGQLSSPESHPKETTNHSRKPVPEGQWQSETLCRECPTTPERPGGRLKLTLRMKRSPVLDDLVESGTSLSEDSFEPEYEVLRVEGVEGSVKRKKKHKTRDRERRHKRRELNLDPPPPPPMKRLRLIFGNETHTIDLPHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MS05</accession>
    <name>A0A8J2MS05_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="6">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HICCMSTLAB_LOCUS11377</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="6"/>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5103173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MS05"/>
    <dbReference type="OrthoDB" id="19653at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00312">
        <property type="entry name" value="Esterase_lipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019819">
        <property type="entry name" value="Carboxylesterase_B_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43142">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43142:SF1">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00941">
        <property type="entry name" value="CARBOXYLESTERASE_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0719">Serine esterase</keyword>
    <feature type="domain" description="Carboxylesterase type B" evidence="7">
        <location>
            <begin position="24"/>
            <end position="560"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG5103173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="582" mass="65429" checksum="BF708E3455C0B391" modified="2022-05-25" version="1">MNIQLVTAVFYCTIYLNGFFSVASPIVKVKNGTLEGSLMKTRRGREFLSFRGIPYALPPIGDLRFEPPKPTTTWSGVKSAKKDAPICTQRNIYTHDDNIVGQEDCLYLNVYTPKLPTKEMKEVGINYPVMIWFHGGGWVTGAGHSDFYNPKYFLDHEVVLVTVNFRLGPLGFLSTEDMVSPGNQGMKDQAQSIRWVNENIASFGGDPNRVTVFGESAGGASTHYHMISPLSRGLIHRGISQSGTALCPWVLTRPGEAKDKSKRLGELLKCPTDNSAQLIACLRKKKAIDIIATDRAYQIFDYDPMIPFKPVVEPNHPGAFLNEEPAESLKNGNMADIPWITGFNSEEGTLKVAGLYGLKEKGYVKQLDENFVELAATTLLYEHTCPKESHKDVAKKIRKFYLGDKPIDESTKFQVIDMYSDAWFNVGADMAVRDHLNTLSSPVYYYYLTYKGSSSFSRIFGAPQGDYGVSHADELQYLFPVGEQLFKDTPLNKEDHKMIDVLTQLWFNFAKTGNPTPSITQQIPLKWKPVRTEALEYLLISDSKNLKMSKNLLKERIDFWASIPHRGNVITSNKITHSKDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MSZ0</accession>
    <name>A0A8J2MSZ0_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Similar to RPA2: Replication protein A 32 kDa subunit (Pongo abelii)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HICCMSTLAB_LOCUS6913</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the replication factor A protein 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5093561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MSZ0"/>
    <dbReference type="OrthoDB" id="25571at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014892">
        <property type="entry name" value="RPA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08784">
        <property type="entry name" value="RPA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Replication protein A C-terminal" evidence="3">
        <location>
            <begin position="126"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG5093561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="217" mass="24097" checksum="A7CDCF121F843A39" modified="2022-05-25" version="1">MWGNDSTSEGGGGGGFMDESYSTATPQADRGETKRSNNVIPLMISDVHKSGRHGTIMAFKWLEAESIPPEGIEVGMYVKIHGTIREQGGDNCHVFVMKIRPVKKYAEVFSHLLEIISISANMKYPKNTLHGKGVEAPTGNKAEDDDMNDDICHGLTNEQKILYKIIKSHDSENGIERNYLKTQVPKNLEAKVDVMLDFLASEGHIYTTCNDDFFKAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MTP0</accession>
    <name>A0A8J2MTP0_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Similar to hd: Protein downstream neighbor of son homolog (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HICCMSTLAB_LOCUS13705</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the DONSON family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5109069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MTP0"/>
    <dbReference type="OrthoDB" id="534063at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033260">
        <property type="term" value="P:nuclear DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024861">
        <property type="entry name" value="Donson"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12972">
        <property type="entry name" value="DOWNSTREAM NEIGHBOR OF SON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12972:SF0">
        <property type="entry name" value="PROTEIN DOWNSTREAM NEIGHBOR OF SON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02064">
        <property type="entry name" value="DONSON"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="52"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="316"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="52"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="63"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="347"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00025806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAG5109069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="641" mass="71849" checksum="7BED99BE131E9E8C" modified="2022-05-25" version="1">MTDIKPVDPPHWIRPEEVQFKLLKQRKNALQARMNSNKVNTNKSLLNISIEKSPSKLDSSQQQKRKNPFAKNNLHKRSREEVKPELDVSCDSILFALINPKPPEPKNVFIPNEDSSSNMSFSSVFNKLELDEQRFPEPELPKGEPYVPIDWTLNTKMRFMSPKPFAWNGKLKTSEQASGTTGFVRCLDTGDQESTLDTSPNARFHQCCLVWQHPSLPWLELYPRSAGKVSASLASNSAVSNNQFIKDALFSEWSESFRSLFHLLRAGQCPYFYVCANTFTVLFRAAGICGISEVHALLTPTTRGFRQSLKQQDIEYTMPLRTTGKRRSDLTDSGYDTLDSTTSNGEDVNDEDNDDDDDDGRDNILESLGIEASEIKRINKCQKRITMEKESEVDASKHSLIFVKGVEAQALFNFLINCKSAVAITGALAGVPPTLLAPVAFHGATLKPLKVRESVVRIENDKFHSLEINGPILPHVLPSLCFLMKSSQLEKFSVSCAQLNSTKSFTDAKHGSVTKKIIRNTQIRTERLLKKVSLKSSIEEKENEKNPPSVFGKENLSDCGLTGELLSHFCNSDPSRIKVTDKTAYAVATISTNYPDSQTGRNFPSICCRNLSPSWRQVLEMNSVVHQVVDKNCFRNSFAPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MWI4</accession>
    <name>A0A8J2MWI4_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Similar to Wipi2: WD repeat domain phosphoinositide-interacting protein 2 (Rattus norvegicus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HICCMSTLAB_LOCUS9851</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the WD repeat PROPPIN family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5100778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MWI4"/>
    <dbReference type="OrthoDB" id="1667587at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000529">
        <property type="entry name" value="WD repeat domain phosphoinositide-interacting protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048720">
        <property type="entry name" value="PROPPIN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11227">
        <property type="entry name" value="WD-REPEAT PROTEIN INTERACTING WITH PHOSPHOINOSIDES WIPI -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21032">
        <property type="entry name" value="PROPPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0072">Autophagy</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="445"/>
            <end position="491"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00025740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAG5100778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="491" mass="53606" checksum="BBD473D7C296E39E" modified="2022-05-25" version="1">MQSLVRNVDVLTQGLKYSISGLMNLANQTAESQSGAFFVNFNQDCTSLSVGSKAGYRIFSVNSVDYLENIYENDTDDICIVERLFSSSLIAVVTYSSPRKLKVCHFKKGTEICNYSYSNTILAVKLNRARLVVCLEESLYIHNIRDMKVLHTIRDTPPNVAGLCILSINSDNCYLAYPGSNTIGEVQIFDAINLQAKTMIPAHDSPLAALAFSPSGTKVATASEKGTVIRVFQVHDGAKLFEFRRGVKRCVSISSLAFSMDSMFLCCSSNTETVHIFKLEESKEPSVIFLFSILTIVIVIMNPKQAPDEAQGWMGYLTKAVCASANYLPSQVTDVFNQGRAFASVHLPFQGLKNVCAITTIEKVLRLLVANADGYLYIYDLDPDEGGDCTLLKQHRLDGKQDEVDCASVSNIGPSTGEGTASVTPSAPIVQNPACINSYAGALRGRSPDSMSGTESEKYHEMIAATESPPKGGTFRLDDDTEFPPVTQRTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MX32</accession>
    <name>A0A8J2MX32_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS10212</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5101139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MX32"/>
    <dbReference type="OrthoDB" id="10541163at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5101139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="121" mass="13322" checksum="383E55EB968EF86E" modified="2022-05-25" version="1">MLGESTRVPELKIQSGRLLDNLLKHQGVEFPPIEDRWRAVKKNKHKECTGLLRRDNTCKGVAFSSNALGVIYQHAVRKEPGGLIGYITARVKSGELFEVDGDMQLMSGLLGSASLVIFLAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MXD8</accession>
    <name>A0A8J2MXD8_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Similar to Ets97D: DNA-binding protein Ets97D (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HICCMSTLAB_LOCUS11434</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the ETS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5103287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MXD8"/>
    <dbReference type="OrthoDB" id="10067219at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08534">
        <property type="entry name" value="SAM_PNT-GABP-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000251">
        <property type="entry name" value="DNA-binding protein Ets97D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000200">
        <property type="entry name" value="GA-binding protein alpha chain, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.50:FF:000039">
        <property type="entry name" value="GA-binding protein alpha chain, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000418">
        <property type="entry name" value="Ets_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046328">
        <property type="entry name" value="ETS_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024668">
        <property type="entry name" value="GABP_asu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003118">
        <property type="entry name" value="Pointed_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11849">
        <property type="entry name" value="ETS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11849:SF195">
        <property type="entry name" value="GA-BINDING PROTEIN ALPHA CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00178">
        <property type="entry name" value="Ets"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11620">
        <property type="entry name" value="GABP-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02198">
        <property type="entry name" value="SAM_PNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00454">
        <property type="entry name" value="ETSDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00413">
        <property type="entry name" value="ETS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00251">
        <property type="entry name" value="SAM_PNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00345">
        <property type="entry name" value="ETS_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00346">
        <property type="entry name" value="ETS_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50061">
        <property type="entry name" value="ETS_DOMAIN_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51433">
        <property type="entry name" value="PNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PNT" evidence="8">
        <location>
            <begin position="176"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="ETS" evidence="7">
        <location>
            <begin position="328"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAG5103287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="433" mass="50549" checksum="6DB8D86C22A0BF02" modified="2022-05-25" version="1">MDQLTPTKHLSTMYDSNGELDFALLRRIKMEPDTILSHDDDIMAQLHQDSSDLEVEPSFALEQLNEEDTNPENLHMQHMDIRQPLSTLKMLLEQKLNFDLSDFQFWLQDAQVLESHKNLVDQCVQGEGLVQVNVKINLAQKKINIVDVLKPAEDYVQVEDQSPEPAQEEKKVIKWTVDTHYKQEQDRLKIPSDPMEWSQTHVKHWLQWAVRQFNLTSIRLADWNIIGEQLCNLELEEFKTKVPNDKGDIFWTHLELLRKCKLVTVIQKDQPESSQDSNKAIMKIRNQKPTKPRAVINQHPRLVSVPLAEPPQQIPLATSSRAVTSSQIQLWQFLLELLTDREHREHIEWVGSEGEFKLHKPDKVASLWGKRKNKPSMNYEKLSRALRYYYDGNMISKVQGKRFVYKFDCDLKNLLGYSAEELSNIVNESPKYC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MY87</accession>
    <name>A0A8J2MY87_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS12596</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5107120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MY87"/>
    <dbReference type="OrthoDB" id="7554877at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5107120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="94" mass="10960" checksum="E67DC0E21A1F026D" modified="2022-05-25" version="1">MLRDQNLTRDSSCNLQQSDKTTISTYGTISHNLNFGLNRNFIGKFRVADVSQPIIGVRFLKHYKLFVNHTNNSLNNFNRLLFNEMLRTKVNILK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-10-16" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>S6CWG3</accession>
    <name>S6CWG3_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cc_bv3.3_31.11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">bv3-3</name>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS6046</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Philos. Trans. R. Soc. Lond., B, Biol. Sci." volume="368" first="20130047" last="20130047">
            <title>Functional endogenous viral elements in the genome of the parasitoid wasp Cotesia congregata: insights into the evolutionary dynamics of bracoviruses.</title>
            <authorList>
                <person name="Bezier A."/>
                <person name="Louis F."/>
                <person name="Jancek S."/>
                <person name="Periquet G."/>
                <person name="Theze J."/>
                <person name="Gyapay G."/>
                <person name="Musset K."/>
                <person name="Lesobre J."/>
                <person name="Lenoble P."/>
                <person name="Dupuy C."/>
                <person name="Gundersen-Rindal D."/>
                <person name="Herniou E.A.Drezen.J.M."/>
            </authorList>
            <dbReference type="PubMed" id="23938757"/>
            <dbReference type="DOI" id="10.1098/rstb.2013.0047"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5092320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="HF586473">
        <property type="protein sequence ID" value="CCQ71127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S6CWG3"/>
    <dbReference type="OrthoDB" id="8120754at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036287028" evidence="2">
        <location>
            <begin position="21"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5092320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCQ71127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="237" mass="26989" checksum="E1FFB17AAABEE10A" modified="2013-10-16" version="1">MFNKMLIALLLVATVDISWAESALSRDSLLNRHRREIDGQSKWVNYGSVGQQYKNNYHFDGTSENGGGSQNSSISTGSVTNQDNNSYSNIDQAANVYLVLPRWYNIANQQTPSAVHGSLGTHLTQPRHRAVREKIDQLKRTCTEIYDGVTEIESANDRGLDRNREKTTQEESNKSLKLNILYHKCKTLMDRLKYQEVRLSQFNDETLPMHDIFDADLAHLRTMLENANLELISLRAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-10-16" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>S6D2X4</accession>
    <name>S6D2X4_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Cc_bv9.2_29.19</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">bv9-2</name>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS6137</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Philos. Trans. R. Soc. Lond., B, Biol. Sci." volume="368" first="20130047" last="20130047">
            <title>Functional endogenous viral elements in the genome of the parasitoid wasp Cotesia congregata: insights into the evolutionary dynamics of bracoviruses.</title>
            <authorList>
                <person name="Bezier A."/>
                <person name="Louis F."/>
                <person name="Jancek S."/>
                <person name="Periquet G."/>
                <person name="Theze J."/>
                <person name="Gyapay G."/>
                <person name="Musset K."/>
                <person name="Lesobre J."/>
                <person name="Lenoble P."/>
                <person name="Dupuy C."/>
                <person name="Gundersen-Rindal D."/>
                <person name="Herniou E.A.Drezen.J.M."/>
            </authorList>
            <dbReference type="PubMed" id="23938757"/>
            <dbReference type="DOI" id="10.1098/rstb.2013.0047"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5092434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="HF586473">
        <property type="protein sequence ID" value="CCQ71188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S6D2X4"/>
    <dbReference type="OrthoDB" id="10445747at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5092434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCQ71188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="108" mass="12755" checksum="7C6A198C0DEEA81D" modified="2013-10-16" version="1">MINHASKKFAIVKFDVISTYGTNPYKVVPFKWVKDTDKNKVLAQYPSKDDVFEEFENILKCNQPKSRWIECSGSLEYLTNSYLDGLIFIKTRRNEFIPEELLFLDYTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-10-16" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>S6D2Y8</accession>
    <name>S6D2Y8_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Cc_bv8.7_32.4b</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">bv8-7</name>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS6188</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Philos. Trans. R. Soc. Lond., B, Biol. Sci." volume="368" first="20130047" last="20130047">
            <title>Functional endogenous viral elements in the genome of the parasitoid wasp Cotesia congregata: insights into the evolutionary dynamics of bracoviruses.</title>
            <authorList>
                <person name="Bezier A."/>
                <person name="Louis F."/>
                <person name="Jancek S."/>
                <person name="Periquet G."/>
                <person name="Theze J."/>
                <person name="Gyapay G."/>
                <person name="Musset K."/>
                <person name="Lesobre J."/>
                <person name="Lenoble P."/>
                <person name="Dupuy C."/>
                <person name="Gundersen-Rindal D."/>
                <person name="Herniou E.A.Drezen.J.M."/>
            </authorList>
            <dbReference type="PubMed" id="23938757"/>
            <dbReference type="DOI" id="10.1098/rstb.2013.0047"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5092519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="HF586473">
        <property type="protein sequence ID" value="CCQ71240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S6D2Y8"/>
    <dbReference type="OrthoDB" id="7671380at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5092519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCQ71240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="136" mass="16005" checksum="ACC5BB68DC101A80" modified="2013-10-16" version="1">MEEVFAKIAFVELAPNIIVPYEWPVDRIYNVVLRSAEEVIMQNTHEDLILQVDGIPARLYRNVKKHRFYHVFKKISKEDMCGCYVYDIALSEDQNTITLEESSGTNSCDDSKLRRKHSYSEDCMISYYYVPHHSYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-10-16" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>S6D4U0</accession>
    <name>S6D4U0_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cc_ben.14_24.1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">ben-14</name>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS6207</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Philos. Trans. R. Soc. Lond., B, Biol. Sci." volume="368" first="20130047" last="20130047">
            <title>Functional endogenous viral elements in the genome of the parasitoid wasp Cotesia congregata: insights into the evolutionary dynamics of bracoviruses.</title>
            <authorList>
                <person name="Bezier A."/>
                <person name="Louis F."/>
                <person name="Jancek S."/>
                <person name="Periquet G."/>
                <person name="Theze J."/>
                <person name="Gyapay G."/>
                <person name="Musset K."/>
                <person name="Lesobre J."/>
                <person name="Lenoble P."/>
                <person name="Dupuy C."/>
                <person name="Gundersen-Rindal D."/>
                <person name="Herniou E.A.Drezen.J.M."/>
            </authorList>
            <dbReference type="PubMed" id="23938757"/>
            <dbReference type="DOI" id="10.1098/rstb.2013.0047"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5092538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="HF586473">
        <property type="protein sequence ID" value="CCQ71259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S6D4U0"/>
    <dbReference type="OrthoDB" id="7701802at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2590">
        <property type="entry name" value="BEN domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018379">
        <property type="entry name" value="BEN_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10523">
        <property type="entry name" value="BEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51457">
        <property type="entry name" value="BEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BEN" evidence="2">
        <location>
            <begin position="676"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="420"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="577"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="457"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="597"/>
            <end position="633"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5092538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCQ71259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="785" mass="88680" checksum="162C29B92C5648CB" modified="2013-10-16" version="1">MKVNYADDYPYVVVEFLQLPYADIGDYVCIPRSWIRVHKATNRKSIVAYPDELPSITKMRIMNCDEPSEKWELYLAIVKVEKRSYKDAYQYIMEKIHNASKNSHSAVIRTSYKRVPVTATKRYSPLLKIVNLSNPQSQKNRNKLKVVDKVDKVRQSGTISNPNKRPQHYNVELRTLTSSKPTGFFFSENTVIKENCKIEHQDQASRDDRSSSDDLLLRYPYIQRKPEKDKETRINSLGAGFRSTGKTFYASKFSPTFVNQICGYTPKPEENRLFSIYRKHLDHIALTQGIQDSRIPNLRTFTLDLPEPLIQDPNIGSNISFAIQNPTNENNQFSQIEILKSTPVIQEHPQVLPNQKTPDQSSEVKCATSEPTTHSHMTCASHASIVCTNSAEHQDSIVEDMVVDELTEASCIEQNVFSGTRAENESSANPKVLEETNHSGQAVESSMEERSPMVEAVTSSGILSSQDVDYDEQSNSSELSSDEIITTSPNSHKQANQSVNSVLNQADVWAEQLFDLFQKMKINFSETCQIAHELYESLVQSQKVIECMANASENLRALKKGKVAVVTSKDVTAEVQQRAEVNQVERKEEESPDVNMEEDKKEDNDVDSKSSENYDDRGGDTKDVKHQDGDNKVPKTTRGHIRSFVLPPEYDPHDTKWTLKYRENDPQLNLVELVSGSNVFINSIKLAHCMRSARDSKALARKLLEEIFTPSALSVCSLTGVRANAFDISGENVRPGLDANARMAILTFVEKHALKKKWGAFDSQSVINTLRSKIQDIRAKHAKTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2E320</accession>
    <name>A0A8J2E320_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Gustatory receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HICCMSTLAB_LOCUS1696</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Cell membrane</location>
            <topology evidence="1 8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the insect chemoreceptor superfamily. Gustatory receptor (GR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001116">
        <property type="protein sequence ID" value="CAG5075542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2E320"/>
    <dbReference type="OrthoDB" id="6366728at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030425">
        <property type="term" value="C:dendrite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043025">
        <property type="term" value="C:neuronal cell body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007635">
        <property type="term" value="P:chemosensory behavior"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008049">
        <property type="term" value="P:male courtship behavior"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050909">
        <property type="term" value="P:sensory perception of taste"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013604">
        <property type="entry name" value="7TM_chemorcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21143:SF133">
        <property type="entry name" value="GUSTATORY AND PHEROMONE RECEPTOR 32A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21143">
        <property type="entry name" value="INVERTEBRATE GUSTATORY RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08395">
        <property type="entry name" value="7tm_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 8 9" id="KW-0675">Receptor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="45"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="75"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="136"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="169"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="255"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="293"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAG5075542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="391" mass="46040" checksum="B90251064E8C4FEC" modified="2022-05-25" version="1" fragment="single">MKLALKILFNFQLSIFQLIGFAPFKIKILEKNNITFKCTQIYKCYNLILILFLITINIYILPHVFVNLYNEKETILSRLLGLVLSYSLTAVIIIICLLYVFQQRKFIKIINQFIEVDLTLNKLKNIYKLDDQSTKFMFITIFNLFFCSSVIICEIFLNEQFHVSFFLYLYQFLVSSFYVIQYAILLTIIEKKFKSINGTFLKLEDSIAAQHPIENIRKYIIYKMCIVEIIVLKRSHTKLFSLCSEIANFYSFGMLFIIPFIIISMIINIYELLIPIITFYVFPNLMLRRVNQFSWMAMVLFPTLMVAMVASQIEDQMKKTGNIVQKILQECSMSPEIRRELKIFSLELLHRDFQFTAYNIIPVDCTILRTIFGAVATYLIIFIQFQADDGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2E7Y3</accession>
    <name>A0A8J2E7Y3_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA replication complex GINS protein PSF3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS5</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="1">The GINS complex plays an essential role in the initiation of DNA replication.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the GINS complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GINS3/PSF3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030000054">
        <property type="protein sequence ID" value="CAG5070416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2E7Y3"/>
    <dbReference type="OrthoDB" id="10251744at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000811">
        <property type="term" value="C:GINS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902975">
        <property type="term" value="P:mitotic DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21693">
        <property type="entry name" value="GINS_B_Psf3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.2050">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010492">
        <property type="entry name" value="GINS_Psf3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038437">
        <property type="entry name" value="GINS_Psf3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055221">
        <property type="entry name" value="PSF3_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22768">
        <property type="entry name" value="DNA REPLICATION COMPLEX GINS PROTEIN PSF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22768:SF0">
        <property type="entry name" value="DNA REPLICATION COMPLEX GINS PROTEIN PSF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22466">
        <property type="entry name" value="PSF3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160059">
        <property type="entry name" value="PriA/YqbF domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0235">DNA replication</keyword>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA replication complex GINS protein PSF3 N-terminal" evidence="2">
        <location>
            <begin position="12"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU367161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5070416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="70" mass="8081" checksum="41B5CDBA8BA0A08B" modified="2022-05-25" version="1" fragment="single">MSLTQSYFPNYFSINEILATEERIQCKIEVNLPRLGFLDITSDLSDLKPGTKLEFPFWLASSLQSRRTPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2EAC9</accession>
    <name>A0A8J2EAC9_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">MULE transposase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS470</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001114">
        <property type="protein sequence ID" value="CAG5073527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2EAC9"/>
    <dbReference type="OrthoDB" id="1711136at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5073527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="423" mass="49030" checksum="292644C6DA094A5A" modified="2022-05-25" version="1">MANKGEIIEEGGFSYYAEKINGNTKTKQCLLYSKYVCCKKRKSKKCPVRSTKTLDEPIQFTVSSHRHALDFYNDDVRRFRRELIAAAEKNLYPTNEIYATVSKSHLEDVRIQLPYAVISTVMRQHQKEAVDELPELPTYKDFAEFFERNENLCFMRYADKKYVIVSNLENDALLIGDPEFSKSGQCDTIHISSTANILPDFNGTRLLTFILGQDGHYAFPVGIILWTKVARDACTEILNQVKERLFPNVNITKIYVDFDLKLFVEEVFPESDVRGTFNNYCHILFHEALSNNDLRLRIPEHEEFLKKCFSLILLPSNKIKEGFEEISNSLSVETKAQLTNFINYFNRVWIEGVTPTSMSLYEKVESLNTVPSRGYYLKQNANILYAVNDGMLIKMFENYLTIQSERQKFLEIYIIVSTNLLID</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2EB35</accession>
    <name>A0A8J2EB35_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Similar to O4: Probable protease inhibitor Egf0.4a (Microplitis demolitor bracovirus (Isolate Webb))</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HICCMSTLAB_LOCUS848</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the serine protease inhibitor-like (TIL domain-containing) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001114">
        <property type="protein sequence ID" value="CAG5074076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2EB35"/>
    <dbReference type="OrthoDB" id="6236007at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030414">
        <property type="term" value="F:peptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19941">
        <property type="entry name" value="TIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036084">
        <property type="entry name" value="Ser_inhib-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051368">
        <property type="entry name" value="SerProtInhib-TIL_Domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002919">
        <property type="entry name" value="TIL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23259:SF70">
        <property type="entry name" value="ACCESSORY GLAND PROTEIN ACP62F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23259">
        <property type="entry name" value="RIDDLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01826">
        <property type="entry name" value="TIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57567">
        <property type="entry name" value="Serine protease inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0646">Protease inhibitor</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035188165" evidence="4">
        <location>
            <begin position="22"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="TIL" evidence="5">
        <location>
            <begin position="28"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAG5074076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="107" mass="11765" checksum="D9A8CC53FD0FEA3E" modified="2022-05-25" version="1">MTRYLLAFTLIFIVANVHVLAEDAEVKCGANEEIDLCGKMCEPTCGCREHNPIFCPGIQCGGVTSACRCKKGFVRNDSRECVSLEDCPKKDDSEPKLAGLKFCLDED</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2ED13</accession>
    <name>A0A8J2ED13_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Venom protein 12</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS1303</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001116">
        <property type="protein sequence ID" value="CAG5075149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2ED13"/>
    <dbReference type="OrthoDB" id="7697653at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051057">
        <property type="entry name" value="PI-PLC_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13593">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13593:SF113">
        <property type="entry name" value="SI:DKEY-266F7.9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26146">
        <property type="entry name" value="PI-PLC_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50007">
        <property type="entry name" value="PIPLC_X_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035158988" evidence="1">
        <location>
            <begin position="26"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5075149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="329" mass="38618" checksum="996411A1D8BE3EC6" modified="2022-05-25" version="1">MTSHFIKKLLISIVFTIYLISSIEACWPKCPDYESKYKKNVPRKRVISHLSDSLEIRQLALIGTRHSASQGTKFRTQDLTISQQLKYGVRVLDSAIWSSSNVFWLYGHWAYYMPFEKFLREVNSFLNAHPREFVIILMREEWKPASDVTKSYCEIVQYYRDLAGGHRIVTNWRLEDTIGQHRGKILLAGLDSAFNICDFDVSNKCRVQKTSIPYGTMSELEEKWIDIQNFHDLIYWIRGRCFVNFLANFRDTNNRKLAVKGFRTRRNDECEAPLNVRMESYFSTPHYALVIVMADFVTQDLIDSILSANFEGIDDKMLLFNNKQYQHEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2EDS4</accession>
    <name>A0A8J2EDS4_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Complex I-B22</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">NADH-ubiquinone oxidoreductase B22 subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">HICCMSTLAB_LOCUS2255</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed to be not involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Mammalian complex I is composed of 45 different subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the complex I LYR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001117">
        <property type="protein sequence ID" value="CAG5076703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2EDS4"/>
    <dbReference type="OrthoDB" id="13598at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006120">
        <property type="term" value="P:mitochondrial electron transport, NADH to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20263">
        <property type="entry name" value="Complex1_LYR_NDUFB9_LYRM3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008011">
        <property type="entry name" value="Complex1_LYR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045292">
        <property type="entry name" value="Complex1_LYR_NDUFB9_LYRM3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033034">
        <property type="entry name" value="NDUFB9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12868:SF0">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 BETA SUBCOMPLEX SUBUNIT 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12868">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE B22 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05347">
        <property type="entry name" value="Complex1_LYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0007">Acetylation</keyword>
    <keyword evidence="10" id="KW-0249">Electron transport</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Complex 1 LYR protein" evidence="16">
        <location>
            <begin position="14"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00030192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00032528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF05347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CAG5076703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="146" mass="17575" checksum="C334DD4B833C73EB" modified="2022-05-25" version="1">MAHSVPTGIVTHARKVCSLYKRILRNYESWYPDFLDFRYEAVLTREIFDKNKDIKDLRVAKKLLLEGELKLEKIMHPQPLYFPESPGGCAHEREVIPPDWVLDYWHPTEKAMYPKYFALREKRKLEYMKLYDKQFPDAPKEFKDVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2EDX1</accession>
    <name>A0A8J2EDX1_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS2330</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001117">
        <property type="protein sequence ID" value="CAG5076946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2EDX1"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5076946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="113" mass="12326" checksum="26FEE1C39F5077DA" modified="2022-05-25" version="1">MNKAIKPIADALKRNKNLINLVIKPAISNSLKVSWINRVNDLIDSVWWSMLYATREKADSCPSADEDEAADGGLPKRLHENTAHAASHAAHHHDALVTLAQDSKPGSSAPRLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2EFI5</accession>
    <name>A0A8J2EFI5_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS523</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the RNase T2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001114">
        <property type="protein sequence ID" value="CAG5073613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2EFI5"/>
    <dbReference type="OrthoDB" id="435754at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033897">
        <property type="term" value="F:ribonuclease T2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006401">
        <property type="term" value="P:RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.730.10">
        <property type="entry name" value="Ribonuclease T2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001568">
        <property type="entry name" value="RNase_T2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036430">
        <property type="entry name" value="RNase_T2-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11240">
        <property type="entry name" value="RIBONUCLEASE T2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11240:SF22">
        <property type="entry name" value="RIBONUCLEASE T2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00445">
        <property type="entry name" value="Ribonuclease_T2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55895">
        <property type="entry name" value="Ribonuclease Rh-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU004328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5073613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="260" mass="31081" checksum="89695AB9386A8600" modified="2022-05-25" version="1">MPKVERFFNNDFKNFSDNRSTRQRFKRHDTLRRIKRTSFSLPRHLPYDYSDNDDGFYVLYLKLIERLCSRDESNCIPNTCKWYIEDFKFQLYNKKNPCHNFTVDFNEEKISSIQSSIDEKWGSSPNWKLYQMSDFTWKFSGSCSLRIPELDDEFKFFKKSIDLYDKFSIGKNLEDKDIIIGGDYSIEEISDAISGVLGGNYAQLGCTEGKNWWKDLNYPRFNELIIFLDKQFSPIKNPGWRKHGYRLQDCQRNVTVYYDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2EHH9</accession>
    <name>A0A8J2EHH9_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS138</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030000802">
        <property type="protein sequence ID" value="CAG5072069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2EHH9"/>
    <dbReference type="OrthoDB" id="10047268at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5072069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="63" mass="7101" checksum="13B1A9F975D8BF93" modified="2022-05-25" version="1" fragment="single">EGEQGYLEGLASKYADIFQTHFGDVLEPLEELRQRETNTSSKISNTQLTTSFSQPIYVPGKYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2EHK0</accession>
    <name>A0A8J2EHK0_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS168</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030000893">
        <property type="protein sequence ID" value="CAG5072700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2EHK0"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5072700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="93" mass="10038" checksum="FDCD6ECBF9AAB86F" modified="2022-05-25" version="1">MHINDKRSDYYQRYSSGPPPQNNYGYGGPVGAGSYNSGGGIGNYPPGDMPPSGHYRNRGYLGDGGGGGGYPSDWRPNRRDYDRRPPPPSNANT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2EHM3</accession>
    <name>A0A8J2EHM3_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Similar to SCAP: Sterol regulatory element-binding protein cleavage-activating protein (Homo sapiens)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HICCMSTLAB_LOCUS8</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endomembrane system</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030000072">
        <property type="protein sequence ID" value="CAG5070419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2EHM3"/>
    <dbReference type="OrthoDB" id="361494at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032936">
        <property type="term" value="C:SREBP-SCAP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032934">
        <property type="term" value="F:sterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045540">
        <property type="term" value="P:regulation of cholesterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032933">
        <property type="term" value="P:SREBP signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030225">
        <property type="entry name" value="SCAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057041">
        <property type="entry name" value="SCAP_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46378">
        <property type="entry name" value="STEROL REGULATORY ELEMENT-BINDING PROTEIN CLEAVAGE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46378:SF1">
        <property type="entry name" value="STEROL REGULATORY ELEMENT-BINDING PROTEIN CLEAVAGE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24006">
        <property type="entry name" value="SCAP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="domain" description="SCAP N-terminal" evidence="6">
        <location>
            <begin position="70"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF24006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAG5070419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="118" mass="13013" checksum="DAF54C4FEEBEF994" modified="2022-05-25" version="1">MSRSLPDRVAGLYYAHGLFCSSHPVAILSLAISIILICCYPLINLPMPGNTPKVVINTTVTNGSNRSESSLLYVQQVSLRIGVVPWAEDLALSDAFRAPLYEVFNLLEIIQNYQDTET</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2EI90</accession>
    <name>A0A8J2EI90_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Similar to harbi1: Putative nuclease HARBI1 (Danio rerio)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HICCMSTLAB_LOCUS561</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the HARBI1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001114">
        <property type="protein sequence ID" value="CAG5073688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2EI90"/>
    <dbReference type="OrthoDB" id="7657299at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045249">
        <property type="entry name" value="HARBI1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027806">
        <property type="entry name" value="HARBI1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22930">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22930:SF289">
        <property type="entry name" value="DDE TNP4 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13359">
        <property type="entry name" value="DDE_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE Tnp4" evidence="9">
        <location>
            <begin position="171"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="332"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="351"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAG5073688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="362" mass="41805" checksum="309C47C2321F9BEA" modified="2022-05-25" version="1">MNFLGLYNIDIDDNNDIDLDLDDDDLIIRIPKRYIRDVQDPFDFYSEIEFKQRYRFDKDSVKFGILPLIEQNLCKVNKRGLPIPPIFQLLICLRFYATANFQFILGDTMTVSQPTVSRIVFRVSVLLASQIHDYIKMPRTQAAKLENQRLFERLGFGNGAIRIPGVDGAIGCTHIRLIHTRFQNINEIYRNRKGYFSLNVQTIVGPRMEFLDIVPEWPGSADDSRIFQNSRIYKRYSERELTGILVGDARYPCLPFLMTPIANPVTDEQIAYNNIQSRTRIIVERTYGVWKRRFPCLSRGLTTKLICSTTIVVACAVLHNLSLIFNDKLPDDDLQDDQNKEPNEEIPAPQPNLQPNEANIVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2EJT0</accession>
    <name>A0A8J2EJT0_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Tubby-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HICCMSTLAB_LOCUS1466</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the TUB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001116">
        <property type="protein sequence ID" value="CAG5075312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2EJT0"/>
    <dbReference type="OrthoDB" id="8775810at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061512">
        <property type="term" value="P:protein localization to cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.90.10:FF:000001">
        <property type="entry name" value="Tubby-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.90.10">
        <property type="entry name" value="Tubby Protein, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025659">
        <property type="entry name" value="Tubby-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000007">
        <property type="entry name" value="Tubby_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018066">
        <property type="entry name" value="Tubby_C_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16517:SF7">
        <property type="entry name" value="PROTEIN KING TUBBY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16517">
        <property type="entry name" value="TUBBY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01167">
        <property type="entry name" value="Tub"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01573">
        <property type="entry name" value="SUPERTUBBY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54518">
        <property type="entry name" value="Tubby C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01200">
        <property type="entry name" value="TUB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01201">
        <property type="entry name" value="TUB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubby C-terminal" evidence="7">
        <location>
            <begin position="163"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG5075312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="413" mass="46751" checksum="05213349C65A4E79" modified="2022-05-25" version="1">MTSLDIRQQKLEQQRQIIAQKMRQKRQTGAAGMVQASAIPGATFISPTGKWVAPANDIHVFDGSMQYTMSPTKSNKNLSDIKTPTVELQHTDNVFDEALETRDCVDEESSPLDTRLGGEPISLRSTLPVAPSDPDAVIVNRENNSNSPELEGNVEGNIEQFVLQPANKKMHYKCRITRDRKGMDRGFYPTYFLHLERDYGKKVFLLAARKRKKSKTSNYLISTDPTDLSRDAESFVGKLRSNLIGTQFTVYDNGYSLMKDDKKHNERANPRQELAAVVYDTNVLGFKGPRKMTVIIPGMTPDQKRISICPRDDSETLLESWKMKNMDNLIELHNKTPVWNDDTQSYVLNFHGRVTQASVKNFQVVHDTDTDYVVMQFGRVAEDVFTMDYRFPLCALQAFAIALSSFDGKLACE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2EKH6</accession>
    <name>A0A8J2EKH6_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Flavin-containing monooxygenase</fullName>
            <ecNumber evidence="8">1.-.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HICCMSTLAB_LOCUS1761</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the FMO family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.-.-.-" evidence="8"/>
    <dbReference type="EMBL" id="CAJNRD030001116">
        <property type="protein sequence ID" value="CAG5075607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2EKH6"/>
    <dbReference type="OrthoDB" id="66881at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000138">
        <property type="entry name" value="Flavin-containing monooxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000960">
        <property type="entry name" value="Flavin_mOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050346">
        <property type="entry name" value="FMO-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23023">
        <property type="entry name" value="DIMETHYLANILINE MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000332">
        <property type="entry name" value="FMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0274">FAD</keyword>
    <keyword evidence="3 8" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7 8 9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="6 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAG5075607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="464" mass="53097" checksum="0C1C8AF21A9A788A" modified="2022-05-25" version="1">MSGNIETTRKKIKICVIGAGAAGLCAIRHLSNDLISFEPAVFEQSEVIGGTWVYSEKTQADLGHPIHSSMYKNLRTNLPLQLMNFPDFQRMDQTEPSCGTHEQIQKKSFKEKLFNEGPVNGNHRRRCKTFKQGLDAAVQRCLINSNHRRRYEAFKRRLDPAFNMKIINVEPILKEEDWRKTEWKVTIKNLKTDLVEENNFDAVLICNGHYSEPKIPKISGIETFSGDVMHSHDYRCPEKYTGKTVIILGAGPSGIDIGIEITGYATHVYLSHNGPRFSSALPQNMTEITRVKFVNGNEFHLTDATTVVADDLLYCTGYNFSFPFLDETCHIKVDNDHVNTLFNHLINIKHPKMAFVGIPFKVIPFPMFHIQVQYFLKLLRGQVTLPSLEVMIEDSKVKTNKAHALEALQWEYNDYLADAAGIDKLPKFYKIGYSEWSVKRTENLLRYKYSKIEIIDDQTVKISI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2EP05</accession>
    <name>A0A8J2EP05_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">guanylate cyclase</fullName>
            <ecNumber evidence="2">4.6.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HICCMSTLAB_LOCUS2102</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.2" evidence="2"/>
    <dbReference type="EMBL" id="CAJNRD030001116">
        <property type="protein sequence ID" value="CAG5076121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2EP05"/>
    <dbReference type="OrthoDB" id="1890790at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008074">
        <property type="term" value="C:guanylate cyclase complex, soluble"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004383">
        <property type="term" value="F:guanylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019934">
        <property type="term" value="P:cGMP-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070482">
        <property type="term" value="P:response to oxygen levels"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07302">
        <property type="entry name" value="CHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1230:FF:000030">
        <property type="entry name" value="Si:ch211-215j19.12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1520.10">
        <property type="entry name" value="H-NOX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.260">
        <property type="entry name" value="Haem NO binding associated domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001054">
        <property type="entry name" value="A/G_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038158">
        <property type="entry name" value="H-NOX_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011644">
        <property type="entry name" value="Heme_NO-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011645">
        <property type="entry name" value="HNOB_dom_associated"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042463">
        <property type="entry name" value="HNOB_dom_associated_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024096">
        <property type="entry name" value="NO_sig/Golgi_transp_ligand-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45655">
        <property type="entry name" value="GUANYLATE CYCLASE SOLUBLE SUBUNIT BETA-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45655:SF5">
        <property type="entry name" value="SOLUBLE GUANYLATE CYCLASE 89DA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00211">
        <property type="entry name" value="Guanylate_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07700">
        <property type="entry name" value="HNOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07701">
        <property type="entry name" value="HNOBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00044">
        <property type="entry name" value="CYCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111126">
        <property type="entry name" value="Ligand-binding domain in the NO signalling and Golgi transport"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50125">
        <property type="entry name" value="GUANYLATE_CYCLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0141">cGMP biosynthesis</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Guanylate cyclase" evidence="9">
        <location>
            <begin position="408"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="263"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="266"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAG5076121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="598" mass="67807" checksum="CDDC05F09C59B5A1" modified="2022-05-25" version="1">MLELASALAEKIGVSANKTVEFFGRCFVRFFSNLGYGCMIKATGRYFCDFLQSVDNIHIQMRFTYPKMKSPSMYITHIDPHGVVLVYRSNRQGLTHYLIGGSKMNLNKKKKMIKFWNSAGILFQIAKDLYETTLDIRVLENLNNIPGSRNVMVKFRIDFDNREYTAKTNRMKAPIGRELSPVSCGLLLRLFPFGVMVNREMRIEGAGEKLLQVWGGNNSILNRHIAEIFKLRRPKGISFTWRNVIYLYSVMFELELIRSNETVTNSDRDPGSSKSGLDRKGSHGARSILLKGQMRYIEDIKSIIFLCSPLINSLDELPSMGLYLNDLNPHGMSREMVLAGWQHCDRLEMMFERAEQRSEELETSYALLDRWKNKSDELLYSMIPQTVADRLRSGSNPLSTCESFESISVLFCELCDFDYSTIEGVMDIVSSMNAVFSCFDSLMDKFNVYKVETVGRIYMAASGAPDRTKHHARNIADVSLQLIKRVRSLQLPSGIDIQIRIGIHSGPAVAGVVGIKVPRYCFFGDTVNTASRMQSTGLPGKVHISPETKALLPSDRYRVESRGVLWVKGKGNMETYWLYGTDESPTKENSPQTIITNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H2I2</accession>
    <name>A0A8J2H2I2_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS1446</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001116">
        <property type="protein sequence ID" value="CAG5075292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H2I2"/>
    <dbReference type="OrthoDB" id="7679028at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="155"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="200"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5075292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="382" mass="45062" checksum="CD5CAA5BAF0504EC" modified="2022-05-25" version="1" fragment="single">MDLLSSFYLCLRSQNYIMVYTFNPFTNYAPHPWKEVEVTNKPDPRWTSYNLRLTQDNDMCRLLQFDKSKLLNGYPVRISAYANISFQLHSTILRFTIPKINDYTWTPNALKRIDNNIENAIPSYDELRFAIATKSRYIISTFIEIDSVIDPYTSIFAISILLLIITLIALVNEYQFLAAIVDVYRHGSTFTYSKISYAHYLYLSVYIFGFVFSPVLQGQVFALLTKPSYRNIETLQDLYDYNYHVYYDTNIHDNIMDAGLWTTDDDQKYLHRIDDPFSLECFELARHHSSFAFKCELYVSKGLIFPTNYVRFSRKDWALNDRVGQRVLHTTKAGIFNYLKREQLDNKLKRMKAIEKASELENYNLIDESNLIAMSRRRSKDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H321</accession>
    <name>A0A8J2H321_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Similar to cah-3: Putative carbonic anhydrase 3 (Caenorhabditis elegans)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HICCMSTLAB_LOCUS1796</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the alpha-carbonic anhydrase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001116">
        <property type="protein sequence ID" value="CAG5075659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H321"/>
    <dbReference type="OrthoDB" id="429145at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004089">
        <property type="term" value="F:carbonate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00326">
        <property type="entry name" value="alpha_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.200.10">
        <property type="entry name" value="Alpha carbonic anhydrase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001148">
        <property type="entry name" value="CA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036398">
        <property type="entry name" value="CA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023561">
        <property type="entry name" value="Carbonic_anhydrase_a-class"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18952">
        <property type="entry name" value="CARBONIC ANHYDRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18952:SF270">
        <property type="entry name" value="CARBONIC ANHYDRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00194">
        <property type="entry name" value="Carb_anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01057">
        <property type="entry name" value="Carb_anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51069">
        <property type="entry name" value="Carbonic anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51144">
        <property type="entry name" value="ALPHA_CA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035268159" evidence="2">
        <location>
            <begin position="19"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-carbonic anhydrase" evidence="3">
        <location>
            <begin position="19"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG5075659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="242" mass="27184" checksum="A9D0FB6C2E607F93" modified="2022-05-25" version="1">MLLIYLVFIIANICSIKSHDWGYTDENGPNNWPGVCKNGKRQSPINIETDNTLKDDLGSLKFLHYDYAFTGILTNTGHNVQITLSGVPIFLSGGGLTSKYVLEQMHFHWGAEHTIDGTRDALELHLVHHDKNIEIQRKVIPVHLLPNDRTTFYRYSGSLTTPGCQESVVWFVMTEKLTISESQVKILKNVQTHNGTLASNYRPTQEAGDRKVYHHLLGYSSSPISTPTPFVFLIAAILSSLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H4W9</accession>
    <name>A0A8J2H4W9_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Medium-chain acyl-CoA ligase ACSF2, mitochondrial</fullName>
            <ecNumber evidence="4">6.2.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HICCMSTLAB_LOCUS240</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="3">Acyl-CoA synthases catalyze the initial reaction in fatty acid metabolism, by forming a thioester with CoA. Has some preference toward medium-chain substrates. Plays a role in adipocyte differentiation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>a medium-chain fatty acid + ATP + CoA = a medium-chain fatty acyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:48340"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:59558"/>
            <dbReference type="ChEBI" id="CHEBI:90546"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.2.1.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>octanoate + ATP + CoA = octanoyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:33631"/>
            <dbReference type="ChEBI" id="CHEBI:25646"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57386"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.2" evidence="4"/>
    <dbReference type="EMBL" id="CAJNRD030001114">
        <property type="protein sequence ID" value="CAG5073242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H4W9"/>
    <dbReference type="OrthoDB" id="10253115at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031956">
        <property type="term" value="F:medium-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.980">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43201">
        <property type="entry name" value="ACYL-COA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43201:SF5">
        <property type="entry name" value="MEDIUM-CHAIN ACYL-COA LIGASE ACSF2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="8">
        <location>
            <begin position="63"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="9">
        <location>
            <begin position="456"/>
            <end position="516"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00037247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00039009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00039638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAG5073242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="534" mass="59811" checksum="D809B72AFB94E861" modified="2022-05-25" version="1">MFLIKKNLSCKKFESLLKHCNRLIKKKGVKLSSNTAAYNDPNLSYRSNPGKEPIIDTTVGKLFEQVSKEFPNRECVVSVEQDNTRLTYSQVLERADKLAAGLKKLNINYGDRVGVWGPNHYQWLISFIGIARAGCIMVGINPAYQQNELNYSLNKVQVNTVIAPDKFRSQDYGKMLREAKNNCSALKNIILWTDKAIPGTYKFSDVESLASKIEIEGIAATQNEISPYDGCNIQFTSGTTGFPKAPLISHKSFVNNGRMTVYRSQLMNYHHKACLNVPFFHAFGMIHGCMVAFNTGMTLVLESPTFNPKKSIETIVKEKCTLAYGTPTMWVNMLDMQDRLKAPISSLHLTATGGAIISPELIKKIRNTFKVEKPSIIYGLTESTAVVFHSVPGDPPELNDYTVGYLHDHLEAMVVDDNGSPVPIGKPGELWTRGYSTMIGYWNDKENTSKTITDNVFGVNDDVYGEEICACIRLKESKTKLTADDIKKFAKGKISNFKIPRYIEFVDEFPKTTSGKIQKFKLKQLMESNGLIPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H508</accession>
    <name>A0A8J2H508_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to IUNH: Inosine-uridine preferring nucleoside hydrolase (Crithidia fasciculata)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS602</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IUNH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001114">
        <property type="protein sequence ID" value="CAG5073783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H508"/>
    <dbReference type="OrthoDB" id="432381at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016799">
        <property type="term" value="F:hydrolase activity, hydrolyzing N-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.245.10">
        <property type="entry name" value="Ribonucleoside hydrolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001910">
        <property type="entry name" value="Inosine/uridine_hydrolase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052775">
        <property type="entry name" value="IUN_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036452">
        <property type="entry name" value="Ribo_hydro-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46190:SF1">
        <property type="entry name" value="SI:CH211-201H21.5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46190">
        <property type="entry name" value="SI:CH211-201H21.5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01156">
        <property type="entry name" value="IU_nuc_hydro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53590">
        <property type="entry name" value="Nucleoside hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Inosine/uridine-preferring nucleoside hydrolase" evidence="2">
        <location>
            <begin position="283"/>
            <end position="506"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5073783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="515" mass="58398" checksum="0D8AC5C5947A407C" modified="2022-05-25" version="1">MEPTPVKEHNHAPNLRLEEERAFVRQLYDRCESRLANTRDIYESLRATYADASRTISWRSQQTNMRRRQQNFIQSLPRVLSLTHLKLCLENDARYDNLTHHSHGSMQLRFRTQNDLGTVAVMGDSELINKFDPNSTMYIGTTNTILPAGLDARETLIIVLLNRNHAFGVSWAFMPDRSEVSFNAALDIACSQIAPLMNPTRIYYDYEQRLNDSLTANIPGATVKGTFLAYANKKNMIKKVIVDCDGGYDDAVSLVLLIDAHKKNIIDLKAITCVAESQALKAAEVRYHGHDGFGDVFTDQVDISKLEKEHAVIAMRKIITENPDQVSVVCLGPLTNVALAVKIYPEILESVKDFFIMGGNSAGQGNTTAQAEFNFYADPESIYILLQCNSKPLWLFPWETCLKSTITMDWRENKLGKLKENKKIKLISTVEDGIYKNKIKREIYRPCDAFCAAALINPKIITHFENCHADIELHGVKTRGFVAIDHLRNNKPNINLVSDLDFQEFKSLMLDSFQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H532</accession>
    <name>A0A8J2H532_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS920</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001114">
        <property type="protein sequence ID" value="CAG5074148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H532"/>
    <dbReference type="OrthoDB" id="7688248at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5074148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="92" mass="10514" checksum="2E9D23D1ECE9D81A" modified="2022-05-25" version="1">MDFCDSLEDPVIVGPFFKAIGLNADNCPPDGVYGTEGYQIPMEYLPDGFMSNNYKVIIEIFYEDINLIIIHTFLKVTTKNCEKKPQFSVCFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H5F7</accession>
    <name>A0A8J2H5F7_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Similar to Luciferin 4-monooxygenase (Photinus pyralis)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HICCMSTLAB_LOCUS649</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001114">
        <property type="protein sequence ID" value="CAG5073877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H5F7"/>
    <dbReference type="OrthoDB" id="10253869at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016405">
        <property type="term" value="F:CoA-ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096:SF149">
        <property type="entry name" value="AMP-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="5">
        <location>
            <begin position="40"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="6">
        <location>
            <begin position="450"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAG5073877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="534" mass="60610" checksum="E5344777591C9BA1" modified="2022-05-25" version="1" fragment="single">MAEEKTMHIPEPTFENGIWKGGKIDMPDGYYKLGERVLNQFKKFPDFVGQIDGATGTKLTYADMGDKSIRCALWLKEQGVSPGDVVGFCSRNHLDSCIPLYACLYIGAIFNPWWHTCLNEELVVNFVERTQPKVLFITENHADVITNSINKMSYPLIIVSFGKKSGLLSFEDVLKTQNDEDINKFQCTRIEPKDPVLIIYSSGSTSFPKGVLHSYHSVAHMLNYYSNDTTPSTVVWFSGLCWISGTRTVLRSIIFKATMILYHNLSEEKACEIIEKYKVTRLWMGASVVNKFTKLRDIEKYDLSSVDLVTYGDASTSREVIQNLCKLFKNADIYVRYGATECGTVLTGLIKYDKFDSCGKIFFNTEVKVVDLNTKKILGPNQRGELWIRTPRLMLGYWKNLSKTEKVIDSKGWYHSGDLVYYDNDGVFFFYTRIKHTIKCDLFDLVPEMIEKIIQGLPGVAEVSVVAKPSLEYGQIPMAFVTKEPGMEVSEGEIIEAVEKKLSNGVKLLGGVYFLDRMPLTPLRKIAIHELRIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H5K5</accession>
    <name>A0A8J2H5K5_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Similar to Tret1-2: Facilitated trehalose transporter Tret1-2 homolog (Drosophila simulans)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HICCMSTLAB_LOCUS2235</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Trehalose transporter subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001117">
        <property type="protein sequence ID" value="CAG5076623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H5K5"/>
    <dbReference type="OrthoDB" id="4142200at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051119">
        <property type="term" value="F:sugar transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17358">
        <property type="entry name" value="MFS_GLUT6_8_Class3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000055">
        <property type="entry name" value="Facilitated trehalose transporter Tret1-2 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044775">
        <property type="entry name" value="MFS_ERD6/Tret1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050549">
        <property type="entry name" value="MFS_Trehalose_Transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48021">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48021:SF47">
        <property type="entry name" value="GH17672P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="36"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="83"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="112"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="136"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="170"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="195"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="280"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="322"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="346"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="380"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="421"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="448"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="43"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAG5076623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="489" mass="53430" checksum="DDFDABA953B767DD" modified="2022-05-25" version="1">MSNTEKEIYVTENEFQIDSSKINLTKTSKGSKCLQFTAAIAANLCVMAAGSLMAWSSPVLLMLQNETVSEENPLGRPITTEETSWIGSILLLGSIAGNLFTGYLSDRLGRRTTLLCSIIPSAVSWVLIFTGKSIEFLYAARFIGGLAAAIPFGVIPVYCGEIAETSIRGILGSFFQLFITLGLLWAYSIGPFISYTNYCIACAVLPIAFFISFYPMPESPYYLAAKSRKEDVIKVLIRLRGKKRAEVETEANEIEVSVQEAYSKQATILDLFKVKANLKALIATCALIFFQQMSGITVVLLYSELIFSSAGEFGLSSSVQTIIVGLVQFLGSCVNPLAVDRLGRKILLIISSSGAGLSLGILGLFFYLKDAAGTQVSHVGWLPVFSLVTYMATYGIGLGPLPWTIMGEMFSQEVKSKASTIVVFTNAFLAFIVSKYFIGFAVTYGQYTAFWFSGIICILCILFTVFYLPETKGRSLQEIQNNLNGKNNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H5Y9</accession>
    <name>A0A8J2H5Y9_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS2498</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001117">
        <property type="protein sequence ID" value="CAG5077557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H5Y9"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5077557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="130" mass="15416" checksum="19D4ADE3C8309A8F" modified="2022-05-25" version="1">MADGNTEDDTLNEVVSLEEEVMMRYRRDRIQLLKMLNTAYEQLLQEKMTNYNYRNSKNITRPNVLEAIKDHIFTQGYQAVVLELPIFLDMSEYVWNIRFCYNAINFFGVTKDTSHGWILVDFLTGCWKIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H609</accession>
    <name>A0A8J2H609_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS2480</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001117">
        <property type="protein sequence ID" value="CAG5077504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H609"/>
    <dbReference type="OrthoDB" id="10033548at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="154"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="198"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="227"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="291"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5077504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="345" mass="36134" checksum="009F3DEA1E6BC096" modified="2022-05-25" version="1">MGDFGGASLFSNTPTTGCRQTSTSSTVTLLSNQVGAMQDDLLIEKQSSAKAAPLSPGLDPPGDKSKDVSEAESIAIAPSTTSSMDKEISGNSSSLQGFTEPVRVPSLWANTSDDSGLHSLPVNGSIATFQNFPAGGPGLFAGSGSRRAITASHNFPQHGNASAPGRHGLQVGNQQQQQQQQQQQQQQQQQQQQQQQQQQAQQTGQQPPSSHPGVYLHGKGYAAWSGGPQGPQQWGGGPQATASSALSPWSRGRSVPNLPPLHSSLHAAAAVAAAAGLQGRKPSPTFPGHSGPNQSHPSNISPVKFRRSTSYPGKGNLYPPQQAPTFEVTTAEERDLLQLPYQQVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H658</accession>
    <name>A0A8J2H658_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS2634</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001117">
        <property type="protein sequence ID" value="CAG5078071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H658"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5078071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="129" mass="15093" checksum="7597DD3A0C856DE1" modified="2022-05-25" version="1" fragment="single">MAPTAMKSVKPFKSYKRFIYFHTHTHTHTHTHTHTHTHMHTDIVTTSRALHTHTHTHTHTHTHTHTHAYRHSDNLAGLVREASYDLYTSRSDENSIFAKRVSRAENFRINNLPSVLNSYKTRSSRDCLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H7H9</accession>
    <name>A0A8J2H7H9_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similar to Defensin (Galleria mellonella)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS3318</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5081556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H7H9"/>
    <dbReference type="OrthoDB" id="10408192at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051707">
        <property type="term" value="P:response to other organism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.10">
        <property type="entry name" value="Knottin, scorpion toxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036574">
        <property type="entry name" value="Scorpion_toxin-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57095">
        <property type="entry name" value="Scorpion toxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5081556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="139" mass="16092" checksum="D4FCF8C12A97280C" modified="2022-05-25" version="1">MESAIHRRMTITNHINRMFSSHFCEGSIHTENKRIYDSQNLIINDIKAKKIVSMLTKNNYCTLLLFFCLAIFAIVPSQQNEDGAEVYIEGYCQALGLSFDKCHFECRYRGYTEGHCRGFMYTDCWCTVPNKNQSPPNSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H7K1</accession>
    <name>A0A8J2H7K1_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Similar to OtopLc: Proton channel OtopLc (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HICCMSTLAB_LOCUS3233</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the otopetrin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5081265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H7K1"/>
    <dbReference type="OrthoDB" id="6429739at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015252">
        <property type="term" value="F:proton channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004878">
        <property type="entry name" value="Otopetrin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21522">
        <property type="entry name" value="PROTON CHANNEL OTOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21522:SF61">
        <property type="entry name" value="PROTON CHANNEL OTOPLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03189">
        <property type="entry name" value="Otopetrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="10" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="33"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="67"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="163"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="227"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="268"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="298"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="327"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="370"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="399"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAG5081265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="444" mass="50523" checksum="4B57F74E53047C63" modified="2022-05-25" version="1">MGAVAFGIGSMIYSGLEFGQYFELERNTKCHNIMLALTPATRMAFIFIQMYFIFLNNQQMKVSSHRLLARFGLMHMIGTNLSVWLNVLVQETKHEILTFYNPENNSLKISHRLGAKGIHLGGHTHTHHGENVRVSRGLKGPHHMFECRRTNIMGSLVQDASPFLFPCTIEYSLICAAILYVMWKNIAKQRSSTNLPTGTTGNHVHAHAYRRSPHYYSVDCARAHKGLFVGILILVLTIISLILFFVLISRSELVSFAVTEVNVCELTLYGMSTVATLIGMIQMRRLRYDGARNLELDNILLIAAQTGMFIYSTFTIISGYFTLERNTILVLVTALASVIQTTFQTIFILDASRRSVSSPEQIRRKPGREIVTFLLVTNLAMWAINTLEKSRAESHPVQLHFYGLWAWTIITHVSMPLAIFYRFHSTVCLCEVWKRAYKVKPTYM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H9E6</accession>
    <name>A0A8J2H9E6_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similar to ANKRD12: Ankyrin repeat domain-containing protein 12 (Homo sapiens)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS3738</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5083125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H9E6"/>
    <dbReference type="OrthoDB" id="5806726at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053210">
        <property type="entry name" value="ANKRD12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24149:SF14">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24149">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="430"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="155"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="285"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="390"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="437"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="461"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="477"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="543"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="559"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="579"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="595"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="624"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="652"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="667"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="698"/>
            <end position="711"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5083125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="920" mass="98362" checksum="AEB7E4DE2D58E1A7" modified="2022-05-25" version="1">MPAGGNSRFRNYPARMSERQQLALLLQITSQDIVLPGPETNASPKTKRTANPETLKVIGSEKLGASEDELATGVKGSEFREFQQELVSSVRVTRPSAGEESGAPCEMRRTPPQNKVDRSATGQSGSSPRVTLRINNVRAGARDEKKGQSRPSFVNTSTSPMDTTTSPSTTTTASSNPTSSNPSPSNPNPNSNASSATSNSSSTNSSANTNSNTNSSSSGNKSASSTAATSSTTTTTSTASSTTASTANASPDTTDIYEFKSSKEPTPVRGTSSSPNLSDKDKELSTSSTNVSSANNNNTNNNNNNNNNNSNNNNNNSNNNNNNNNNNNNNNNSSNNAANVPNSGTGTNSESSSSGANSGGAELSTTGSPASKRTYEDDDQDDEVKRKKRKEGDSKDNKTTPRQNAGRAADKFDKVSTSVTASFVEQCVKAGKPAAASSGTAKNSQNSGPAPSSGAADRKSPSSTAASSPKPAGSNKADSDGDEDRKGSEAAPKVPPLKIVIPQSTAEQEQGARNGKNTSTRGHQLPYVVPSSNSSDSNDKDSAAGAGTSGGTTSPTETAKVEDKKDFSGAIHSEERSTHHQRVLRSSHRGGNGNGTSKDSAQYSNSSPLATDRSNNSSPQARHTSPSPETSTETKPATTESSSNPKSSTSSDKAEKNETKLKEEPAESAPSTTASTPTLTPAELHPRKRKMKPKEVATTTESSEANSTGTEVHPHDQPITNCYQLFLNIRKQIERRRKGLFPVQPKPPQGFKDYLMNRCTYVLAGNANKEPNVKPPANLAEQMKALFIKQESERYRLRMQHVVEKEKLVLSVEQEILRVHGRAARALANQELPFSVCTILKDEEVYNVITPEQEDKERNLRSRYNGRLFLSWLQDVDDKWEKIKWKLKEVGLCEFKAQPQIEDIHVPMVHVSDDFDLLPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H9H1</accession>
    <name>A0A8J2H9H1_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Protein tweety homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">HICCMSTLAB_LOCUS4826</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Probable chloride channel.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Cell membrane</location>
            <topology evidence="1 13">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the tweety family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5088401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H9H1"/>
    <dbReference type="OrthoDB" id="187568at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034707">
        <property type="term" value="C:chloride channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005229">
        <property type="term" value="F:intracellularly calcium-gated chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072320">
        <property type="term" value="F:volume-sensitive chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07912">
        <property type="entry name" value="Tweety_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006990">
        <property type="entry name" value="Tweety"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12424:SF8">
        <property type="entry name" value="PROTEIN TWEETY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12424">
        <property type="entry name" value="TWEETY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04906">
        <property type="entry name" value="Tweety"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11 13" id="KW-0868">Chloride</keyword>
    <keyword evidence="9 13" id="KW-0869">Chloride channel</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12 13" id="KW-0407">Ion channel</keyword>
    <keyword evidence="7 13" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 13" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="48"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="84"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="220"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="247"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="391"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="456"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="465"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="14">
        <location>
            <begin position="507"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="559"/>
            <end position="581"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU361114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CAG5088401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="714" mass="78713" checksum="FD29ECB66B388088" modified="2022-05-25" version="1">MVVGQQLPEQYTVPQLANFFHSLPHLNVSFHLVNNTFNPGSDIYLESLGILGSIPAAWLILTLLVLLVYLVTRCCDRKPRPRRSITLLKCLLAILAVLCSGAVAVGLYGNDDVHNGLVQFLDAAKKIDMSIVSVKNQTETIDSVLRKNLRPSLTSLGDYLDTPVANGTAFKYMMVIWKQVTDNTSIAVERGAELKKHLCCINIGSSIAVVDKIEFFRWPVTMAVLSALLVLCVVLLVGVARHSRCALITFSVFGLFAVIVSWLMASLYLATSVALGDLCVSPDSYLMKNSPTVMVSEVLNYYMRCESTQNHPFTQRLREGQMAAGFMLSSLNAVETIAYELYDKPTLQPKLQSLKDTVIDINGSMSRLTALLDCKPLHKEYIRAAQGLCHLGLYGLTFMLLASLAAGLFFTILVWVDSHTWIYIRKRRDYSQVDEQDPFLPPSAASQAIAARTLRGQGSYPPTAPSLNPNSHGTNNTIKQPLLLTPPPPSYATATARARQLHESMLKGGGVNGSGGIGDHKLSQHNQQSASGRTEHRSGHGDQPGQYATLRREPPWTPSVASFTGTMSHNSHGPSHLATFQDSRKTQTLDPKNLANLKRGPTPAWNQNRPLPPNPSQPSWEFESRSQTNMNQFRSLMKNKTPNIRVQDQVQDQVRTLDRNFSRGQFNGAAPNNVVPNMYGTYNRAQARQEKASAIPTLSQVQGSDPNLYAVTEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HA66</accession>
    <name>A0A8J2HA66_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Similar to Abcb4: Phosphatidylcholine translocator ABCB4 (Rattus norvegicus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HICCMSTLAB_LOCUS5309</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5089627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HA66"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015421">
        <property type="term" value="F:ABC-type oligopeptide transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03228">
        <property type="entry name" value="ABCC_MRP_Like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394:SF1">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY B MEMBER 10, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394">
        <property type="entry name" value="ATP-DEPENDENT PERMEASE MDL1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="33"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="117"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="150"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="531"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="574"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="650"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="759"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="794"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="1"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="212"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="535"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="851"/>
            <end position="1089"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1096"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAG5089627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="1096" mass="124308" checksum="02BA6C1425CE7B40" modified="2022-05-25" version="1" fragment="single">NIGYLQTGLDEKVGNFIATLSTITSCTLVAMYYGYQLAGTLIAVVPVISAIIVITRRVNNCIKKREAHHYRAAQAMVRQTLNHMRCVCAYSKEEYEVNKYISHLAPVEQCDVLKGTILSITGATLWIIIYGMYGFAFWQGVQFLRINKSYSVASLIIVSFSTHIAVFYIFQIPLYINFMWKATIAARKILVMSKRTLKIGGAEPNDADSRIIVFNNVTFRYSLTGQAILKNVSFEIDRGTTVAIFGPQCSGKTTLLALIHRFHFLQRGKISFNGMNIEDIDLFWLRKQIGFAQQCPVLFGTTILESITCLTTCKSLDCVHEVAEIVGMHSLISELPLEYNTPLTWDLQVDQRQRLALARILYRKPEILMMDDSVSALSSVDEEFIFDHLKQTYEKLTIIIVTNNPRILEKVDKILYLTDGRIEEFNSVGQMVQTNPEVDSLIIEKDGTVDNFEVETMAKCRDKQPSCPPVFPRTSSFFGRSYQQLLRSGLVQIGRSGAFLQVPNVSTYTLESRTMMFKNLIKFLLRDKRRWLQLLFAGLASVILGLNAPMYTVLYGETLSLVALFDTSELLKRYKFFTTMFFAAGFVASFCKIVQDSMLSFVDSKLTTRIRRETFRKILQKNMEWFDTEARTICEIVGVLRKPPEAQQGCARRLVFLIETLASVTVSIILSMFYNWKLGLATLFLTPMTLYMLQFNKRLVTERNYHVATSFNKAKKMIIEATRNAEAIAALNLESKFIDLDDDADNLITSNQNNVKLQAFIYGCCVALPQFAYSVAVFYGGYMLNRNEIDSTTVFKVAEAIILGTLLVGHLVLPMESMSHEMNLSSNFVDILDDSKEVKSGVRVPDLQGRITFQQVSFVHSYYAAIPKLYEMNLYIKPGELVAFVGRLHSGVSIPIQLLLGFYKITSGDIFFDDQQLNDVNIKELRRQMGLVEGEPRFFNDSIAYNISYGGNRKMLASEIIATAKKVALHDFISSLPKGYYTVLDDSEIILTTSQKIKLSLARALVRNPRILLFDNLKKCETEEAQQRLEDIISSVAVGRTCIASTHDPLSATRIFSRIIFINRGNISESGTHEELIKANGHYARFWREERNRLSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HA74</accession>
    <name>A0A8J2HA74_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS5325</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5089670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HA74"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5089670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="98" mass="10928" checksum="0BF605E6C4487120" modified="2022-05-25" version="1">MIRVITQVLASRFPWTSKPVKVCLQIQCPVASVSLPFEYRKTMAQSTTIETVTITKPFKLLLMIKYVKWIVNRKVSRASVTPGGKIEGDCALFSASPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HAD6</accession>
    <name>A0A8J2HAD6_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">cyclin-dependent kinase</fullName>
            <ecNumber evidence="2">2.7.11.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HICCMSTLAB_LOCUS4707</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.22" evidence="2"/>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5088086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HAD6"/>
    <dbReference type="OrthoDB" id="1732493at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004693">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000007">
        <property type="entry name" value="Cyclin-dependent kinase 14, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF246">
        <property type="entry name" value="ECDYSONE-INDUCED PROTEIN 63E, ISOFORM N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="179"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="208"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAG5088086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="295" mass="33330" checksum="B59A2850F7A3D601" modified="2022-05-25" version="1">MYCQDKGSATSKGKEGGTVTMRDKKNGALSRVQKLKKRLSHSFGRLSISKEEAEDVANRGPLPYNGFSEEFLDRLERNGNVSGDKDRRYAKSITSTSISHVSEWSGVGDHERVHRQLSVSSDSKLLDEDIREEARVILRPRRPPRPKSEVFLGPDPGPRRTKRFSAFGGDSPFGKSEGYIKLEQLGEGSYATVFKGYSHLAEQVVALKEIRLQEEEGAPFTAIREASLLKELKHSNIVTLHDIIHTRETLTFVFEYVHTDLSQYMAKYGSGGLDPRNVRLFLFQLLRGLAYCHRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HAL4</accession>
    <name>A0A8J2HAL4_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS5521</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5090183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HAL4"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5090183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="147" mass="16412" checksum="33E1A7856D110604" modified="2022-05-25" version="1" fragment="single">MNNSSRKISRKNFIENIFNLIEQFSSLTSFLQAILNHSCVQRKLGRHFFIKLIFISILGPQRQFVIRFVQYLKQGKSSHYSIISKNLRVAELSFSIAALIRGVTPLMSPALISAPCLISNFNISALFAKAAIPIGESLISSSLPILT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HAN0</accession>
    <name>A0A8J2HAN0_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA-directed RNA polymerases I and III subunit RPAC1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HICCMSTLAB_LOCUS4766</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the archaeal Rpo3/eukaryotic RPB3 RNA polymerase subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5088223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HAN0"/>
    <dbReference type="OrthoDB" id="270173at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005736">
        <property type="term" value="C:RNA polymerase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07032">
        <property type="entry name" value="RNAP_I_II_AC40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.120.12:FF:000003">
        <property type="entry name" value="Dna-directed rna polymerases i and iii subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.120.12">
        <property type="entry name" value="DNA-directed RNA polymerase, insert domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.10">
        <property type="entry name" value="RNA polymerase, RBP11-like subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00320">
        <property type="entry name" value="RNApol_arch_Rpo3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001514">
        <property type="entry name" value="DNA-dir_RNA_pol_30-40kDasu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011262">
        <property type="entry name" value="DNA-dir_RNA_pol_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011263">
        <property type="entry name" value="DNA-dir_RNA_pol_RpoA/D/Rpb3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036603">
        <property type="entry name" value="RBP11-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022842">
        <property type="entry name" value="RNAP_Rpo3/Rpb3/RPAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033901">
        <property type="entry name" value="RNAPI/III_AC40"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036643">
        <property type="entry name" value="RNApol_insert_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050518">
        <property type="entry name" value="Rpo3/RPB3_RNA_Pol_subunit"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11800">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11800:SF13">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I AND III SUBUNIT RPAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01000">
        <property type="entry name" value="RNA_pol_A_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01193">
        <property type="entry name" value="RNA_pol_L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00662">
        <property type="entry name" value="RPOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56553">
        <property type="entry name" value="Insert subdomain of RNA polymerase alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55257">
        <property type="entry name" value="RBP11-like subunits of RNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00446">
        <property type="entry name" value="RNA_POL_D_30KD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="DNA-directed RNA polymerase RpoA/D/Rpb3-type" evidence="7">
        <location>
            <begin position="50"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG5088223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="343" mass="39281" checksum="BF082DB9667D54FB" modified="2022-05-25" version="1">MEKVQRISIEEYGVPNAAEYSNLQFNKWDINRFRKNLKVNIVRQSDDKRELEFDMIGCTPALANAFRRALLSEVPSMAIEKVHILMNTSLLQDEVLAHRLGLLPLKADPSLFEYCTADERLDDEAEMNDRTTLKYELKVICSKNTKPIKDSRLPEDIYHHSRVKSNAVKWIPLHRQSEMYPNGEELFGMLEDDILIAKMVPGQEIDVILYAVKGIGKDHAKFSPVATASYRLMPAITLKRPIFGPEAELLKSCFSEGVIELVKNKKRGELEARVKDPRYDSCSRNVFRHESLKNSVKLERIADHYIFNVESIGAVEPGVLFLQAVKVLKDKCRTFLDELDSIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HAP5</accession>
    <name>A0A8J2HAP5_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">THAP-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HICCMSTLAB_LOCUS4241</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5084963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HAP5"/>
    <dbReference type="OrthoDB" id="6598185at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027806">
        <property type="entry name" value="HARBI1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006612">
        <property type="entry name" value="THAP_Znf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23080">
        <property type="entry name" value="THAP DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23080:SF141">
        <property type="entry name" value="TRANSPOSASE HELIX-TURN-HELIX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13359">
        <property type="entry name" value="DDE_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05485">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00980">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50950">
        <property type="entry name" value="ZF_THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="THAP-type" evidence="7">
        <location>
            <begin position="24"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG5084963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="522" mass="59674" checksum="A9E72CF0B04B455C" modified="2022-05-25" version="1">MLCQLQVLRLLLVTMEFPPRKNKSKTFCCVYGCNSKSWRDNTIRFYSFPAANSNLVKIINKFGEDQIIDRRLAWIKALKIGNEVTQYKSVCSLHFTKTNVNQLRFHLKKNSVPSCNLPETSLSTFNQPNLVQIDDRDERRRKRSLKKKSFLNEDTSEINSVLSDDKTGDTGDSSCQSQLCVESATEDLSFVQISAVDEEKQEQNYPSTMKIFKDIGIQVESDYLTPKFSTCIKSDQQLSTLTGLSSFAILNTIEQLVIKVQSMRGTSNSSIKFDLRELLIMTFMKLKQNMSYSTLAIFFNFSKNGCKSQIWKMIDILYLALKPSIHWPSKENILKNIPLCFKNFEGVRVVVDCTEIKIQKPSKLCCQLQTYSYYKSTYTVKFLTGVTPAGTIFFVSRAYGGRASDNTIFEQSNIINMMDKKDIVLADKGFTMHDFCKKYDVTLCTPDKQQFSKSEANMNRYVAKVRVHVERSNQRIKTFDVLGSTMPVCLLSKVEEIFTIICGVVNLSASILKKNKFHSENI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HBF2</accession>
    <name>A0A8J2HBF2_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Similar to sob: Protein sister of odd and bowel (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HICCMSTLAB_LOCUS6261</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5092628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HBF2"/>
    <dbReference type="OrthoDB" id="9451254at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048619">
        <property type="term" value="P:embryonic hindgut morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016348">
        <property type="term" value="P:imaginal disc-derived leg joint morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007366">
        <property type="term" value="P:periodic partitioning by pair rule gene"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000958">
        <property type="entry name" value="Odd skipped"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000254">
        <property type="entry name" value="Odd-skipped related transciption factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000318">
        <property type="entry name" value="Odd-skipped-related transciption factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000311">
        <property type="entry name" value="protein odd-skipped-related 2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050717">
        <property type="entry name" value="C2H2-ZF_Transcription_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14196">
        <property type="entry name" value="ODD-SKIPPED - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14196:SF11">
        <property type="entry name" value="PROTEIN SISTER OF ODD AND BOWEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0562">Pair-rule protein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="106"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="134"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="162"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="190"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAG5092628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="254" mass="28874" checksum="ABBA2897AA1C4E8B" modified="2022-05-25" version="1">MMETAKMEPLTPPHTPPSLNVNPGLGRWMGSRMGPMHPGAHLPGFHAAFLDHWVRGAALIAARGSPYGLPAHPPHPGQMNPGQPLPGPPTSFLARRLPGQRPKKQFICKFCNRQFTKSYNLLIHERTHTDERPYSCDICGKAFRRQDHLRDHRYIHSKEKPFKCTECGKGFCQSRTLAVHKILHLEESPHKCPVCSRTFNQRSNLKTHLLTHTEVPQDLRVDTQTSQSILPIRTESMLKKPPKLGFSIEDIMRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HBJ2</accession>
    <name>A0A8J2HBJ2_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Similar to lark: RNA-binding protein lark (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HICCMSTLAB_LOCUS5967</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5092186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HBJ2"/>
    <dbReference type="OrthoDB" id="79941at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12343">
        <property type="entry name" value="RRM1_2_CoAA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000545">
        <property type="entry name" value="RNA-binding protein lark"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48038">
        <property type="entry name" value="RIBONUCLEOPROTEIN RB97D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48038:SF1">
        <property type="entry name" value="RIBONUCLEOPROTEIN RB97D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="10"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="83"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="6">
        <location>
            <begin position="167"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="281"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="314"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAG5092186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="327" mass="36207" checksum="BBD3F86CD5EBCF25" modified="2022-05-25" version="1">MPGFSSVGTFKIFIGNLADKTSNSDIKPLFEKYGKVVECDVVKNYGFVAGRNAIQNLNGTPVHGQPIKCEAAKSRKGPNTPTTKIFVGNLTDNTKAPQVRELFAKYGTVVECDIVRNYGFVHLEASGDVNDAIKELNGQMVDGQPMKVQISTSRVRQRPGMGDPEQCYRCGRGGHWSKECPKGGMGGGPDRNGFRDRMFGRDPYPPPPPPPFLRDRIMGGRGFGVSFDDSRDLYERRFSGMSGPRDMDSSMLGRDFPPMSMPPLPARRDPMPPMPALGMGTMRDSGFSRGNDYGMFSRRSPPPSGNNGRFSRGMYEDFSRDSFEERR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HC54</accession>
    <name>A0A8J2HC54_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS5220</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5089391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HC54"/>
    <dbReference type="OrthoDB" id="8188337at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="41"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="160"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="160"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="173"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5089391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="182" mass="19447" checksum="26FF20B8E20CE34F" modified="2022-05-25" version="1">MSLEESRRSQRPYRYGMVLLCVGALINWLGLAENYVEPVRYVGVACIVAGALLICAAMCCWLHAPPVRTNVGTHGSNHPNTIQILMNIYCLEGSYPGSMNDVEEPASVARQKPPDYDAVADAPPSYDDAIKLNPGQLTTRASISGISPILPGMITMSNNSSATSGISNDQPTAPTPPPAYAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HCG8</accession>
    <name>A0A8J2HCG8_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Similar to Tspo: Translocator protein (Mus musculus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HICCMSTLAB_LOCUS5372</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TspO/BZRP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5089776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HCG8"/>
    <dbReference type="OrthoDB" id="8841220at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033013">
        <property type="term" value="P:tetrapyrrole metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd15904">
        <property type="entry name" value="TSPO_MBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1260.100:FF:000001">
        <property type="entry name" value="translocator protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.100">
        <property type="entry name" value="TspO/MBR protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038330">
        <property type="entry name" value="TspO/MBR-related_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004307">
        <property type="entry name" value="TspO_MBR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10057">
        <property type="entry name" value="PERIPHERAL-TYPE BENZODIAZEPINE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10057:SF0">
        <property type="entry name" value="TRANSLOCATOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03073">
        <property type="entry name" value="TspO_MBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005859">
        <property type="entry name" value="PBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="48"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="78"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="107"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="133"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAG5089776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="169" mass="18777" checksum="92A183827F3D46DB" modified="2022-05-25" version="1">MPVHIPWPATVAVVLPNLGGWAGAFVTRQNISPWYKTLNKPTWTPPNWMFGPVWTGLYCSMGYASYLVYRDGGGFENAAVPLSIYGVNVALNWMWTPIFFGAHNIKLALYEIAALWGSTVVLGISFFKVNKLAGGLIVPYLAWITIAAALNYSVYRNNKITDVTDEKEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HCR9</accession>
    <name>A0A8J2HCR9_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS6983</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5093650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HCR9"/>
    <dbReference type="OrthoDB" id="5917530at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="180"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="180"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="195"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5093650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="238" mass="25869" checksum="B38B3A44D0DE773F" modified="2022-05-25" version="1">MSQLGTTNYSNVLLDNENNGNFSECLSLGGGLIVLASALSDASYESPTRYSFSSTSGSTEDNGLPKYQYGWCLQLSGLALILAEIAALLTVSGYMARFPTVEEMYRFRAFDDIKHVTYADNTKSECLLDAPLGFNRYNSMAGQTVPITLKHQNSPTVSAIQAQAMYQNFGTIHSGILRVSEPGTSSSSNSSQRSMTLQNPKRKSQIAQNTFSTLECEKRKPRAAGIAGKMNFYTGSTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HCT4</accession>
    <name>A0A8J2HCT4_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Similar to WDR46: WD repeat-containing protein 46 (Homo sapiens)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HICCMSTLAB_LOCUS7464</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5094948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HCT4"/>
    <dbReference type="OrthoDB" id="10251154at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000378">
        <property type="entry name" value="U3 small nucleolar RNA-associated protein 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012952">
        <property type="entry name" value="BING4_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040315">
        <property type="entry name" value="WDR46/Utp7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14085:SF3">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 46"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14085">
        <property type="entry name" value="WD-REPEAT PROTEIN BING4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08149">
        <property type="entry name" value="BING4CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01033">
        <property type="entry name" value="BING4CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="3 6" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="272"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="domain" description="BING4 C-terminal" evidence="7">
        <location>
            <begin position="352"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG5094948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="522" mass="59146" checksum="ADD5DF8AA54E44CB" modified="2022-05-25" version="1">MAEKKKMREGKYPGRAPVDKKVLKKYYRGTGVEVRRSKTKIKNKYNIARLKKREKLIEKTLEDTARAELLLTESGGYLETDAGETTTQFRQTDIAANVDITSAAKFFDLDLAFGPYYPKYTRNGRHLLLGGKMGHVAAFDWVTKKLSCEMNVMESVHDVTWFHQETMFAVAQKEWVYVYDNQGIEIHCLKRMNRATKLEFLPYHFLLCSGSSDGNLAWVDVSTGELLKRYNTQVGKIRVMTQNPTNALLLIGNSKGVVSMWSPNLQEPLVRMLCHRQAISACTVHPYGTYMATSCPDRSLKIWDARQLTGPVHNIMLRSPADNVAYSQKGMLAVSTGNVVEVFKESGADMKRYLSHRSSWNVSGMQFCPFEDVLGVGSEKKFTSLLIPGSAEANFDALEINPFQTKSQRNEREVKSLLDKIQPEFITLNPEAIAEVDVSKLKEKVDAKNKLPFVKPKNIDFKPRETKAKGKGGTAKVVKTKKILKELEKRKEIESLPTIKKTKVDKKVKKNYGQALNRFLPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HCV8</accession>
    <name>A0A8J2HCV8_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS5091</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5089070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HCV8"/>
    <dbReference type="OrthoDB" id="7684701at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050745">
        <property type="entry name" value="Multifunctional_regulatory"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24189">
        <property type="entry name" value="MYOTROPHIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5089070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="508" mass="58980" checksum="47710BCDE938DDB7" modified="2022-05-25" version="1">MDPELIPTRTGNSLMYQAIGDKLKNLKLLLENGMDVNEPMITTGEFAGFTALHVACMTSCDDLVELLVNDYKADVNAMAADGTQPIHLACFYLPLDSILGITRERELGFKKIKTLVKANANVDAEFGLEIFSKHIKYREWCPDFGDKIPLVVYTVIDDKTSIIHHLKNVNLDIISLANKTLLMYAVEKTCYSHIPAIMSNVEDPELIDKLINHRDNDDVPLTHYPLHPKIYGKFRYHKAMMSYILFIEPEFISILSSLGVDMYALINNDPATFLPNLSAYRSCPTLLEHSLPYYTSMSLSRVLYYATLPIDEESKHLVSYDSERERLDDLESIRENRKYCIIIALRDLVFRVAFRLPVPEQEIKLMDELIASDENLRKIVNNYKANFIEKELQDRFIEFGDNKITIHDFLMQIFDNKKLKILAREENLLDSLYQVFHVDFHDRSFQKFYHPIKIRIEDAMERLRLFENLKKISSLRKAIPLPFEVVLEIVEYLKNKHLNVFIKAFYTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HDZ7</accession>
    <name>A0A8J2HDZ7_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Similar to BBX: HMG box transcription factor BBX (Homo sapiens)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HICCMSTLAB_LOCUS7831</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5095684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HDZ7"/>
    <dbReference type="OrthoDB" id="2377365at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21989">
        <property type="entry name" value="HMG-box_HBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049523">
        <property type="entry name" value="BBX_HMG-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052412">
        <property type="entry name" value="CC-Dev_Transcription_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13059:SF10">
        <property type="entry name" value="HMG BOX TRANSCRIPTION FACTOR BBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13059">
        <property type="entry name" value="HMG-BOX TRANSCRIPTION FACTOR BBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HMG box" evidence="8">
        <location>
            <begin position="15"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="6">
        <location>
            <begin position="15"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="91"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="151"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="233"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="305"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="364"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="416"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="472"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="108"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="173"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="243"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="256"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="324"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="346"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="364"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="420"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="490"/>
            <end position="501"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAG5095684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="534" mass="60661" checksum="B286099BBDBE6777" modified="2022-05-25" version="1">MENEQREPEEPAHHARRPMNAFLIFCKRHRGSVRLHFPHLENRAVTRVLGEWWATLHPDQKQSYINLAQEYKDAFLNANPDFKWYKLPAPPLRTLTTRPTNKKPDVGSSYEENSTSTSNSNYESSTYTNNDNNNAIQPGKLADESQIGGLSSLFTPQKNQPHHKKGADVDRIPDDDEDDDFVDDDDDDELPNIENKNITNGTEEIVVPKPPKKRYTELPINLEQKKDCKADLFGGSRTENAESNNNSSSNNNNNKHPLDLDEEGKKRDTNSYIEVNSPEDGNFRSERSCKGLRYQKFLAEQVRNIGSTTQQNKRRRTGLNKVTGVEKHTKERRNSISSNVSEKTDSLSSEGGNSSRSDLEHLVDSAEGKVEASKPENTGTDEAEYELWTRKRFKAEDFNLEKKIEALPSLSLEEFQEKKKQQRTKKKKLPQKLNTTSITKRTSVNQNKIGQLDSQANNRKETNEIINLHDETTNAHLVGSQKRKARKQSITRNTSATSSKNSTEEKNQPWCASPDLEALACLAELAANRTKLTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HEG3</accession>
    <name>A0A8J2HEG3_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Similar to RpL37A: 60S ribosomal protein L37a (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HICCMSTLAB_LOCUS5983</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL43 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5092218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HEG3"/>
    <dbReference type="OrthoDB" id="10258345at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011331">
        <property type="entry name" value="Ribosomal_eL37/eL43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002674">
        <property type="entry name" value="Ribosomal_eL43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48160">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48160:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01780">
        <property type="entry name" value="Ribosomal_L37ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="Zn-binding ribosomal proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG5092218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="70" mass="7955" checksum="D840BF141FEE6901" modified="2022-05-25" version="1">MFLYKFISLQVHAVLHFVLDILDAMKRSVVGIWSCKRCKRTVAGGAWVYSTTAAASVRSAVRRLREVKEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HEP6</accession>
    <name>A0A8J2HEP6_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HICCMSTLAB_LOCUS6642</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5093171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HEP6"/>
    <dbReference type="OrthoDB" id="8050739at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="109"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="38"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="53"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG5093171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="222" mass="24467" checksum="94801E642B72B242" modified="2022-05-25" version="1">MEKGEMYRAPPSRDDSYVAECAYPRSSRSDRRKTHVHAVADDTIPEKPAKRSTGGRKSRSRGSRAAPIDPKADDCCLEEEVTAVSAEETKTRKPNEDKSRDLRRRLRFCFNCGETDHFVWTCPNPHRDICPRCGTLGLTAITCTCPQQTLSSPASEFGLCHVSDDAYWDLKVGRPRPMVVICSNGKRSTAIVDTGAKTTTFGSFAAEIMNSGCSVLTEVTPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HEV0</accession>
    <name>A0A8J2HEV0_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS8406</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5096829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HEV0"/>
    <dbReference type="OrthoDB" id="7701337at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5096829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="285" mass="33242" checksum="2508821CBC70213F" modified="2022-05-25" version="1">MKKKGGRKVKAEDRRVYKVGFWNVVGIKNKDEDFWKRLEEWDVVVLIEIWVDKKGWERIKQSWKRGFIWELQEARVQKGRGRAKVGMLVGVKEEIKTGRRNIVSDEGWTENEVKLGNEWWWVVGVYINGDVGRKREDGEEIRNSKVKVVNKEGNELCKFLSERGWAIANGCIKGDEEGEWTFVGERGCSKKITEVKVEKRIESDPMPVVAGIGVKWDISGRGRKRAVKGTTRGIWSKEGIRKFGEEFKEWYGVKRSVEEDWQELKEKARRAIKVTEKIREKKSGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HF34</accession>
    <name>A0A8J2HF34_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Similar to rab3gap1: Rab3 GTPase-activating protein catalytic subunit (Xenopus laevis)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS8564</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5097145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HF34"/>
    <dbReference type="OrthoDB" id="17346at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045700">
        <property type="entry name" value="Rab3GAP1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21422">
        <property type="entry name" value="RAB3 GTPASE-ACTIVATING PROTEIN CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21422:SF9">
        <property type="entry name" value="RAB3 GTPASE-ACTIVATING PROTEIN CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5097145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="453" mass="51393" checksum="2C53A7E8DB3EAABB" modified="2022-05-25" version="1">MHNVEIEDFYHHDFTTASEWEVFIARLEEIIHEWKLPHSKLEPALKSGDFVNLTWEVKSEELNFANYPFLFKHFKLKTSDSTDKIDSETSDEDSSTQSHIDVLNITNDFARVDQDYLEIARYYGIREFVLLTPAKKISISDETRIKILVSSLTIASTNSNSEVPALVQVQEPWQKYYLGVIVGKGTITHLDMVHLKKTPPHCRHLTGLLALFKQKIGEGSGVRLDPVMVSIRFAYVLKDWLTEPHFDFMKGKPVTNNELGKLPFGAEVDPVSELQVYATWPQMSENIVVDSESFTDLEPQLATEWSARVKMVATPPSLLEEHLKGFLNLCNNQKLLVDILGDAYVDNDQMLSSAFNIVTESKIPTISKVMSRASSKKSNKNDGPIPDDTLMLILQNLGGIQAVAQIWHEFVQEMRYRWDESILIPGANAPGHVTVFGQHINLNPLIFTQHITD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HFP1</accession>
    <name>A0A8J2HFP1_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="6">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HICCMSTLAB_LOCUS8541</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the PPP phosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="6"/>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5097099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HFP1"/>
    <dbReference type="OrthoDB" id="1930084at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07415">
        <property type="entry name" value="MPP_PP2A_PP4_PP6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000003">
        <property type="entry name" value="Serine/threonine-protein phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047129">
        <property type="entry name" value="PPA2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45619">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE PP2A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0464">Manganese</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="7">
        <location>
            <begin position="114"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG5097099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="320" mass="36694" checksum="A5D0D8C95E5CBF35" modified="2022-05-25" version="1" fragment="single">MEDKASLKELDQWIEQLNDCKQLTESQVKTLCDKAKEILAKESNVQEVKCPVTVCGDVHGQFHDLMELFRIGGKSPDTNYLFMGDYVDRGYYSVETVTLLVALKVRYRERITILRGNHESRQITQVYGFYDECLRKYGNANVWKFFTDLFDYLPLTALVDGQIFCLHGGLSPSIDTLDHIRALDRLQEVPHEGPMCDLLWSDPDDRGGWGISPRGAGYTFGQDISETFNHSNGLTLVSRAHQLVMEGYNWCHDRNVVTIFSAPNYCYRCGNQAAIMELDDALKYSFLIQHHDVENHMSPGGHRITSSKELKYQDDRFKTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HGD6</accession>
    <name>A0A8J2HGD6_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Similar to Gsx1: GS homeobox 1 (Mus musculus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HICCMSTLAB_LOCUS7163</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5093837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HGD6"/>
    <dbReference type="OrthoDB" id="6159439at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020479">
        <property type="entry name" value="HD_metazoa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45664:SF20">
        <property type="entry name" value="AGAP001560-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45664">
        <property type="entry name" value="PROTEIN ZERKNUELLT 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00024">
        <property type="entry name" value="HOMEOBOX"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 5 6" id="KW-0371">Homeobox</keyword>
    <keyword evidence="4 5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="8">
        <location>
            <begin position="114"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="5">
        <location>
            <begin position="116"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="53"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="213"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="53"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="71"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="216"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAG5093837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="337" mass="38036" checksum="6D2A935B3E807491" modified="2022-05-25" version="1">MSRSFLVDSLIGDNSPPSYSLPYYGSQLPNYMFNFFNFGLGYQPVRPVPRPPTLPGPVPLSPPAIMGMPLSRQSPPSPLNSSASRLSDFSGANESPTRSTTPTPPPKSPNSLSNSSKRIRTAFTSTQLLELEREFAANMYLSRLRRIEIAKNLRLSEKQVKIWFQNRRVKYKKEDLPAGQSAKCCCLRTCGKKKEDCDDKKCSTPASVEEELSEEDKDKGCEDKIRASTPENDKQGIKEECKESSSDIVQDLRTSNDYSRFPGFFDYQDRGRRENINVCDVIGSESRKRSYDAFQDSEIVKKRMMSVDPYMTSLKEGPIIVRTNTHTKYTVESIVNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HHN0</accession>
    <name>A0A8J2HHN0_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Similar to Tle4: Transducin-like enhancer protein 4 (Mus musculus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HICCMSTLAB_LOCUS9448</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat Groucho/TLE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5100227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HHN0"/>
    <dbReference type="OrthoDB" id="2624652at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090090">
        <property type="term" value="P:negative regulation of canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000001">
        <property type="entry name" value="transducin-like enhancer protein 3 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009146">
        <property type="entry name" value="Groucho_enhance"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10814:SF36">
        <property type="entry name" value="PROTEIN GROUCHO-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10814">
        <property type="entry name" value="TRANSDUCIN-LIKE ENHANCER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01850">
        <property type="entry name" value="GROUCHOFAMLY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 6" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="381"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="423"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="505"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="23"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="65"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="132"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="156"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="196"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG5100227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="581" mass="62255" checksum="DCC08648CE2ADD54" modified="2022-05-25" version="1">MEMESYRGNPGFRIEDRAEKIHFAANPSGMLGSSISPAEREKYSRPRSTPDPGHHDHMHLKKMKKEQDKDLGHQSDGEKSDQDLVVDDASEGAASPAANGTSSPRENGLEKMGPSVGLMSSQMKKEIPPQSPKSGTSSNASTPSAKKMEEREKPSTPISKPVTPTSAGGSSSGSGGLKPSGSNKPLVPASAVGPYPHYPPPHHPPAGPHVEMLGYPPGALNGYPTRPPLQQLYDPHGAMRAPLGPLGVPGGKPAYSFHVSSEGQMQPVPFPQDALIGPGIPRHARQINTLTHGEVVCAVTISNPTKYVYTGGKGCVKVWDISQGGSGSAKPVSQLDCLQRDNYIRSVKLLPDGRTLIVGGEASNLSIWDLASPTPRIKAELTSAAPACYALAISPDSKVCFSCCSDGNIAVWDLQNQTLVRQFQGHTDGASCIDISADGSKLWTGGLDNTVRSWDLREGRQLQQHDFTSQIFSLGYCPTGEWLAVGMENSNVEVLHANKPDKYQLHLHESCVLSLRFASCGKWFVSTGKDNLLNAWRTPYGASIFQSKESSSVLSCDISTDDKYIVTGSGDKKATVYEVIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HHN3</accession>
    <name>A0A8J2HHN3_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Similar to Cuticle protein 19 (Locusta migratoria)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HICCMSTLAB_LOCUS9050</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5099411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HHN3"/>
    <dbReference type="OrthoDB" id="6427684at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042302">
        <property type="term" value="F:structural constituent of cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031311">
        <property type="entry name" value="CHIT_BIND_RR_consensus"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000618">
        <property type="entry name" value="Insect_cuticle"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051217">
        <property type="entry name" value="Insect_Cuticle_Struc_Prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12236:SF95">
        <property type="entry name" value="CUTICULAR PROTEIN 76BD, ISOFORM C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12236">
        <property type="entry name" value="STRUCTURAL CONTITUENT OF CUTICLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00379">
        <property type="entry name" value="Chitin_bind_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00947">
        <property type="entry name" value="CUTICLE"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00233">
        <property type="entry name" value="CHIT_BIND_RR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51155">
        <property type="entry name" value="CHIT_BIND_RR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0193">Cuticle</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035260517" evidence="3">
        <location>
            <begin position="23"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG5099411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="153" mass="17471" checksum="0BC9777A812AD456" modified="2022-05-25" version="1">MSILHILTFIGWLFTNIEFSITQRYNWPYKEQSVYKLLKPASLTTIPKHPPIIYVAPPILKSSDKKTRRKESKVNYTDYPMYSFNYGVTDGYTGDSKSAWEERNGDAVRGKYSVVEADGSIRTVTYTADDKNGFNAVITQSFAHLKLCALKLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HI12</accession>
    <name>A0A8J2HI12_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Uridine kinase</fullName>
            <ecNumber evidence="17">2.7.1.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">HICCMSTLAB_LOCUS8146</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="15">May contribute to UTP accumulation needed for blast transformation and proliferation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 17">
            <text>cytidine + ATP = CMP + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24674"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17562"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.48"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14 17">
            <text>uridine + ATP = UMP + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16825"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16704"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.48"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="17">Pyrimidine metabolism; CTP biosynthesis via salvage pathway; CTP from cytidine: step 1/3.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 17">Pyrimidine metabolism; UMP biosynthesis via salvage pathway; UMP from uridine: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="16">Interacts with RNF19B.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 17">Belongs to the uridine kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.48" evidence="17"/>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5096310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HI12"/>
    <dbReference type="OrthoDB" id="10257085at2759"/>
    <dbReference type="UniPathway" id="UPA00574">
        <property type="reaction ID" value="UER00637"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00579">
        <property type="reaction ID" value="UER00640"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004849">
        <property type="term" value="F:uridine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044211">
        <property type="term" value="P:CTP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044206">
        <property type="term" value="P:UMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02023">
        <property type="entry name" value="UMPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2020:FF:000010">
        <property type="entry name" value="Uridine-cytidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000200">
        <property type="entry name" value="Uridine-cytidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006083">
        <property type="entry name" value="PRK/URK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000764">
        <property type="entry name" value="Uridine_kinase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001097">
        <property type="entry name" value="PRK00129.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004018">
        <property type="entry name" value="PRK05480.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00235">
        <property type="entry name" value="udk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10285">
        <property type="entry name" value="URIDINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00485">
        <property type="entry name" value="PRK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14681">
        <property type="entry name" value="UPRTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00988">
        <property type="entry name" value="URIDINKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 17 21" id="KW-0418">Kinase</keyword>
    <keyword evidence="8 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 17" id="KW-0808">Transferase</keyword>
    <keyword evidence="11" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="Phosphoribulokinase/uridine kinase" evidence="19">
        <location>
            <begin position="115"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphoribosyltransferase" evidence="20">
        <location>
            <begin position="342"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="30"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="72"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00056790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00065923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU003825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF00485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF14681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="CAG5096310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="553" mass="62186" checksum="9C24C93D97084CB8" modified="2022-05-25" version="1">MAAEVQHFEPPSSASSESDGDICLEDRAVFLADGASDDGDDTRELVNPSPQVPPRPASTGSQKSPRSRRQRTTSMSQSSKKTSTECILRSKLRTIYIAGRPAWYDSAGQQVEPFVIGICGGSASGKTTVATKIIEFLNVPWVTLLSMDSFYKVLNEKQHHQAALNEYNFDHPEAFDFELLKLTLQRLKEGRKVDVPIYNFVTHSRESRTKTMYGANVIIFEGILTFYNAEVLKMCDMKVFVDTDADVRLARRLHRDISQRGRDLEGVLKQYSAMVKPAYCYYIAPSMVHADIIVPRGGENEVAIKLIVQHVHTQLQLRGFKLREKLAHSYTGQPLPSVYMLPDTPQVKGLHTLIRDKNTERDEFIFYTKRLIRLVIEYALSLLPYKDVVIDTPQGIPYHGKRVASNKICGVSIMRAGETMEQALCDVCKDIRIGKILIQTNENTDEPELFYQRLPKDIKDYRVILMDATVATGAAAVMAIRVLLDHDVAEDNIFVVSLLMAEPGVHSIAYAFPRVKIVTSAIDPEINDRFYVIPGIGNFGDRYFGTEPLNDLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HI55</accession>
    <name>A0A8J2HI55_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS10806</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5102020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HI55"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5102020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="74" mass="8588" checksum="DB2872730FDF5A8A" modified="2022-05-25" version="1">MLNSISVPVYMEKKIFSSQEFILLTQENHFRQHGILGSRVWLLSQVNFFISVRLLFITIGNICDIGNEFAEQII</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HIQ8</accession>
    <name>A0A8J2HIQ8_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ras-associating domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS11139</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5102698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HIQ8"/>
    <dbReference type="OrthoDB" id="3908708at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045742">
        <property type="term" value="P:positive regulation of epidermal growth factor receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045743">
        <property type="term" value="P:positive regulation of fibroblast growth factor receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17043">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000159">
        <property type="entry name" value="RA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21298">
        <property type="entry name" value="GH01721P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21298:SF2">
        <property type="entry name" value="GH01721P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00788">
        <property type="entry name" value="RA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00314">
        <property type="entry name" value="RA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50200">
        <property type="entry name" value="RA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ras-associating" evidence="1">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-associating" evidence="1">
        <location>
            <begin position="99"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5102698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="248" mass="28876" checksum="40C831EAA34D425D" modified="2022-05-25" version="1" fragment="single">TTIKVYANCLRPDIEYKTLSITYETTCHQVVQNLLNKYRMRHRDPRLFYMTMEVTVRRANVRTILPLDEDARPAVLQSCHPRGDSRFSLQTRRGGLSKYKSLLISERTTVDELIQMLLNCYNSAERVEQFSLYEVCEGEEYQRKLHPDDSPLKVTQKWTSIDRHLRIRRNPDYDPHRRKSMWASDSTISAAISKSNSSTSASQECGRNQLTRSTKMSNLLPQSLPSTPLTSKHLTASHFSNYENFFYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HIW7</accession>
    <name>A0A8J2HIW7_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Stress-activated protein kinase JNK</fullName>
            <ecNumber evidence="11">2.7.11.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HICCMSTLAB_LOCUS8688</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating a number of transcription factors, and thus regulates transcriptional activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.24"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.24"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.24" evidence="11"/>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5097399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HIW7"/>
    <dbReference type="OrthoDB" id="192887at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036477">
        <property type="term" value="C:somatodendritic compartment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004707">
        <property type="term" value="F:MAP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903034">
        <property type="term" value="P:regulation of response to wounding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd07850">
        <property type="entry name" value="STKc_JNK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000009">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000210">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003527">
        <property type="entry name" value="MAP_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050117">
        <property type="entry name" value="MAPK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008351">
        <property type="entry name" value="MAPK_JNK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24055">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01772">
        <property type="entry name" value="JNKMAPKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01351">
        <property type="entry name" value="MAPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 11 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 11" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="32"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU368052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAG5097399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="391" mass="44821" checksum="5C4EB6CD7102C39B" modified="2022-05-25" version="1">MPYLGPEMTTRLSAMFYTVEVGDTKFTILKRYQNLKPIGSGAQGIVCAAYDTVTQQNVAIKKLSRPFQNVTHAKRAYREFKLMKLVNHKNIIGLLNAFTPQRSLDEFQDVYLVMELMDANLCQVIQMDLDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTTFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPAQEFMQRLQPTVRNYVENRPRYPGYPFERLFPDILFPTDSSEHNRLKASQARDLLSRMLVIDPERRISVDDALLHNYINVWYDEGEVNAPAPGPYDHSVDEREHTVDQWKELIYQEVMEYETSHNPAATAQSSVDPVAGSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HJ12</accession>
    <name>A0A8J2HJ12_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS11273</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5102965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HJ12"/>
    <dbReference type="OrthoDB" id="7687839at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035272208" evidence="2">
        <location>
            <begin position="19"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5102965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="178" mass="20303" checksum="6B66A5C9B473CB69" modified="2022-05-25" version="1" fragment="single">RNLQALLVLVELLPLSNAAMSKINKADRKKKGRTAKKIDSNGKENQKGKKRKLDEMEDDESLDGTSIKDFARSVATKKKSNSGQSVDKTFVQGDGWFISVHPESQPITTFDLLYKTYYVLNVEYPETLKNFYNFIDYFIFHMNAESINMVCSLYTSLSNFNIDSRKKGTDDAFENNSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HJ26</accession>
    <name>A0A8J2HJ26_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to DENND6B: Protein DENND6B (Homo sapiens)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS9810</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DENND6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5100737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HJ26"/>
    <dbReference type="OrthoDB" id="10265409at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055037">
        <property type="term" value="C:recycling endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11500">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001194">
        <property type="entry name" value="cDENN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043153">
        <property type="entry name" value="DENN_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024224">
        <property type="entry name" value="DENND6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037516">
        <property type="entry name" value="Tripartite_DENN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13677">
        <property type="entry name" value="LD41638P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13677:SF0">
        <property type="entry name" value="LD41638P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02141">
        <property type="entry name" value="DENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50211">
        <property type="entry name" value="DENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDENN" evidence="2">
        <location>
            <begin position="14"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5100737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="559" mass="64329" checksum="CB75BBF27A308EA4" modified="2022-05-25" version="1">MTKCGWENFDNWIHCICVVTFDLELGQALEAIYPSHVKLSETERSNVCYLAFPDSNSGCMGDTRYHVRIRRNFLESQDNTSRKEYNRKSPAFLQCSEDYYWGYIYFRQVKNHDLPRGYFQKSVVIVSMLPFVNLFGELCALLAQEFFESGNTIMEVAIREIDQWLPPTPGELINLHLLGVLFQTYIPNENYKANVASITGIDNASDPSSVQPVRKLIMASALEDDMFQSLLNIISHVHLLWELVLLNEPILVMAGSPKTCANMVQALVAMIVPFKYCSDYRPYFTIHDSEFKEYTSDVAVPPAVILGVTNPFFAKTLQRWPHIIRVCDVTNNDSKKYKIKKVDSLKILDSKPGVYTQYKTFLQKDKTLLKKLIRGVQTKRPREVQAALLKRHLMELTESFMIPLERYIASLMPLQKNISPFKATPIPQLFNPEDFLATVSTAGPQLTIGIKGDWAGLYKRFFRTPNFSGWFNLRYSELTHKLQALQLEALSHADLKTWVQDKQEVEIIDMILKIRQKLEISHSEDIPTTQAVRVRLSERLNDITRTLPDDLKVILKHES</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HJI3</accession>
    <name>A0A8J2HJI3_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Similar to RAD52: DNA repair protein RAD52 homolog (Gallus gallus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HICCMSTLAB_LOCUS9070</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RAD52 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5099450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HJI3"/>
    <dbReference type="OrthoDB" id="206565at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045002">
        <property type="term" value="P:double-strand break repair via single-strand annealing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006312">
        <property type="term" value="P:mitotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.80">
        <property type="entry name" value="DNA repair protein Rad52/59/22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041247">
        <property type="entry name" value="Rad52_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007232">
        <property type="entry name" value="Rad52_Rad59_Rad22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042525">
        <property type="entry name" value="Rad52_Rad59_Rad22_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12132">
        <property type="entry name" value="DNA REPAIR AND RECOMBINATION PROTEIN RAD52, RAD59"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12132:SF1">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD52 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04098">
        <property type="entry name" value="Rad52_Rad22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54768">
        <property type="entry name" value="dsRNA-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="4" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="138"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="218"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="16"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="144"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="179"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="224"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAG5099450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="277" mass="31508" checksum="DB0C7711112438B1" modified="2022-05-25" version="1">MSFSSCIKLPSFKTENSPEKDISSRGNMDNDKQTYNELITIANEIFGHGKWSHAVTSQTVDFVEYVMGRYLIGCAAFVRVQLPDGTFHEEMGYSNAESSVKGTAVFEARVSSITNALKKSLLCFGGIIETKINEKISSHKSKIQKTSDNKLFQNDQRAKTEPSKVSTSNSEILEYANSPKERMRKESLREEKKDGLKEPKKDEVKVINSVSTTTSTVQLIKAPSKSTENTPRTTAMTEEELRIERKRKQKEKQEEYRRQMMLKGEEIKIDDKVQKDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HKB4</accession>
    <name>A0A8J2HKB4_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Large ribosomal subunit protein mL37</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">39S ribosomal protein L37, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HICCMSTLAB_LOCUS9526</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the mitochondrion-specific ribosomal protein mL37 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5100383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HKB4"/>
    <dbReference type="OrthoDB" id="5835618at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052482">
        <property type="entry name" value="mtLSU_mL37"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010793">
        <property type="entry name" value="Ribosomal_mL37/mL65"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15889:SF2">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15889">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOMAL PROTEIN L37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07147">
        <property type="entry name" value="PDCD9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="2" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00039442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00041617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAG5100383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="375" mass="43304" checksum="0DEDBAB51E316C44" modified="2022-05-25" version="1">MKITQVLLRQHLGRMFKYNWFFHSRQTLGETRTDHKLKELDISVIDPEELLNPPKPRIDARPFFEHSTIGYREIKDENHPDWKERPCFKLNTNDLLVMGTDQAQVLTKTLLVKEGLPDKIEGLIKDNSKEVDNIVKRIIQTSNIFDTHQEKLPIKKDPARPAWNFPRDYGLTDIRKSRNLAQSMIQLCELLCGPSIVRKRQLVHNGEVQVPLEKDGDLLMFNMTVDFMVTATKGLTPIEITEDLKDKTIPEIYPLKNVKNITELPVKKNQLIARSLVKSFTTAASCAYQKYGADVKELPEPITIQCVQSNSQAFHFSVFQLNTLNINGTEGPKNFWWSMPEIDLFDTAMYVKGRPVLEGYNPEVFKRILAFYTNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HLZ1</accession>
    <name>A0A8J2HLZ1_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS13071</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5108105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HLZ1"/>
    <dbReference type="OrthoDB" id="545063at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="195"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="453"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="195"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="219"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="453"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="494"/>
            <end position="510"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5108105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="728" mass="83188" checksum="3CDAC6BA376B36E1" modified="2022-05-25" version="1">MMTKPKIGETPHQSYLFYYRAPLRTMTEGSSRTKRMGTRFFKNPPQPHMCIQDFLRGSVHPCYINVLSWDKIAMASCPFERLPLYGGMKINPPRTEKPEVNVFFVMANPEVLRKKGKYAHDLKEQSILIELLLNFIEAMNNGVEFMRQYKILNDRDITGELKEIWMVVQSDKARAQSDPASEEVKRPVPQYPLYSEQEQQQQQKKQHQQQQYRPPPPQTQQLQHQIQQIHQTHSEDSHQQIQPQPPQYHSNYSMQNRGHVKTSENYDLAYVRQPQNLPIPQNDHIYQPWSTSLQYANRVRRMEQKISSREAREFLASNVSVNSSPQQQHSMSYPASQYQYQLPRQIGPAYNGPKVHPNASDLTCSTITTSGGINPGISPGSQMHYDHYYLPMRLPEKNVCVKVHRVQQPQQPQLQLANPIHMAPVPPYEPIDPFYDPQMNSSFNWRRSITSQNHTTLPKNNNNKRQFSPSHTSNNGPKENSEKSKSPIKVLQRDNSNNSSSNVDSINSEISVDKSDQEFDNTANKKKIQVTDLDEDELQITPTCDNSEEIQSLDDIQTQKIIQESSSKNQVRTKILIPKRNKISNDSKSILKNGNSVTNDIETEHPSNIENTVIEEKNQQINISESERNGFNNDKPIKSDSKVSKVINNCSSASVINAGTSEDNNEQCESKVNGQGYNLNKSDGQVYQVYTILRKSDVASTQDGLTNEITQMAIKDCTETSEMGAVPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HM89</accession>
    <name>A0A8J2HM89_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CHK kinase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS13238</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5108440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HM89"/>
    <dbReference type="OrthoDB" id="411145at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015897">
        <property type="entry name" value="CHK_kinase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004119">
        <property type="entry name" value="EcKL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11012:SF56">
        <property type="entry name" value="CHK KINASE-LIKE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11012">
        <property type="entry name" value="PROTEIN KINASE-LIKE DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02958">
        <property type="entry name" value="EcKL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00587">
        <property type="entry name" value="CHK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CHK kinase-like" evidence="1">
        <location>
            <begin position="154"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5108440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="391" mass="45167" checksum="41F2AFC978B265AE" modified="2022-05-25" version="1">MSIETVIRSVENLPKSIDNIQKNGIVSENSDWTNMIFEKILLNGLRDYTIQDVAIINKRLACTKGQNFLSQVWRLSLRYTCVPKNNSFKRIKKIVHLIMKEEPLPGFSLDFIRENGIFNVELMVFTNILPSLERLTGRQFAPRFFSGSTQPPTIILEDLKPLGFKNKCRQSGLSQAHMLKVIEAIAQFHAGSAALNEQQPGRFLRFTSRSSSEETHASMYDWLDFIIDQIADKIRKWSEPWAIRASDKLKKLRRVTQHQKLLKVSEYDNDEFCVLNHGDCWIGNFILKVDYDDYFIKKYVEILSKSMKRYGCSTPPPTLQDITRAMHKRRIYGLMSGLIFYPRMIADVSDIEAIDDCFKSGTTKMNIFKNPRAVKALKKMIPAMLEKGYLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HMC8</accession>
    <name>A0A8J2HMC8_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Similar to CCT6: T-complex protein 1 subunit zeta (Oryctolagus cuniculus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HICCMSTLAB_LOCUS11577</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5103573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HMC8"/>
    <dbReference type="OrthoDB" id="10052040at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03342">
        <property type="entry name" value="TCP1_zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.560.10:FF:000038">
        <property type="entry name" value="Chaperonin containing TCP1 subunit 6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.560.10:FF:000058">
        <property type="entry name" value="T-complex protein 1 subunit zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.260.10:FF:000017">
        <property type="entry name" value="T-complex protein 1 subunit zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.7.10:FF:000004">
        <property type="entry name" value="T-complex protein 1 subunit zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012722">
        <property type="entry name" value="Chap_CCT_zeta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002194">
        <property type="entry name" value="Chaperonin_TCP-1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053374">
        <property type="entry name" value="TCP-1_chaperonin"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02347">
        <property type="entry name" value="chap_CCT_zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041083">
        <property type="entry name" value="thermosome_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="CHAPERONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00750">
        <property type="entry name" value="TCP1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00751">
        <property type="entry name" value="TCP1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00995">
        <property type="entry name" value="TCP1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 7" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG5103573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="531" mass="57843" checksum="4DE7650A19536D37" modified="2022-05-25" version="1">MAAISLLNPKAEVARASQALAVNISGAKGIQDVMKTNLGPKGTMKMLVSGAGDIKITKDGNVLLHEMQIQHPTASLIARASTAQDDMTGDGTTTTVLIIGELMKQADLFISEGLHPRIITEGFELARVKTLEVLESLKTPIECTKEGLIDVAKTSLRTKIHPKIADKLAEVCVDAVLAIKQGDQPIDLHMVELMEMQHRTAADTTLVRGIVMDHGSRHPDMPKRIENAYILTCNVSLEYEKTEVNSGFFYKTAEEREKLVAAEREFIDNRVKKIIALKKKLCTGNDKGFVIINQKGIDPPSLDALAKEGIMALRRAKRRNMERLALACGGTAVNSVDDLQEDSLGWAGLVYEHVLGENKYTFVEDCKKPNSVTILLKGPNKYTLVQLKDAVRDGLRAINNAIEDKAVIPGAGAFEVVASRALSQYKEQVKGKLRFGIQAYSEALLVVPKILAVNSGFDPQYTIVKLLEESATLGEPVGLDINSGEAIKPSDMGIYDNYIVKKQIINSCTVIASNLLLVDEIMRAGLSSLKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HN58</accession>
    <name>A0A8J2HN58_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Translation initiation factor eIF2B subunit epsilon</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">eIF2B GDP-GTP exchange factor subunit epsilon</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HICCMSTLAB_LOCUS11881</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subunit">
        <text evidence="8">Component of the translation initiation factor 2B (eIF2B) complex which is a heterodecamer of two sets of five different subunits: alpha, beta, gamma, delta and epsilon. Subunits alpha, beta and delta comprise a regulatory subcomplex and subunits epsilon and gamma comprise a catalytic subcomplex. Within the complex, the hexameric regulatory complex resides at the center, with the two heterodimeric catalytic subcomplexes bound on opposite sides.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eIF-2B gamma/epsilon subunits family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5104196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HN58"/>
    <dbReference type="OrthoDB" id="424572at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005851">
        <property type="term" value="C:eukaryotic translation initiation factor 2B complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031369">
        <property type="term" value="F:translation initiation factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11558">
        <property type="entry name" value="W2_eIF2B_epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.180:FF:000022">
        <property type="entry name" value="Translation initiation factor eIF-2B epsilon subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051956">
        <property type="entry name" value="eIF2B_epsilon"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056764">
        <property type="entry name" value="LbH_EIF2B3/5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003307">
        <property type="entry name" value="W2_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044123">
        <property type="entry name" value="W2_eIF2B_epsilon"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45887">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT EPSILON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45887:SF1">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT EPSILON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25084">
        <property type="entry name" value="LbH_EIF2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02020">
        <property type="entry name" value="W2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00515">
        <property type="entry name" value="eIF5C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="Trimeric LpxA-like enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51363">
        <property type="entry name" value="W2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 11" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="W2" evidence="10">
        <location>
            <begin position="442"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="410"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="410"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="426"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00044144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00044345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00046432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAG5104196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="619" mass="70304" checksum="5B2C81FAA2651E8A" modified="2022-05-25" version="1">MLDNQQSVQAVVLADDFSTSLLTPLQHIFPSILTPVANLNLLDYIVYDDITVSLILSDGCRSLGDALRDIDTKGWIRGDFVLIRGDAFINTNLLTLLSKHKAKKDKDKGIAMSVVFRDIGSSRPTNLTSNTCFSVVNKLTDQLIFYKPSNLESHQKKLQFELSWFLDHEQIEINTGIIDTHVYMCSQTVLSLFSDNFDFQTMEDFIKGVLLNEEILDSRIYRLILEAGDYALPISSWAAYHTLTRDILQRQSYPLTPDMLAPFNNIVYSSKSTYKYKNSGLARGCILKNDSIVGSNSQLGNNTLVSRSTIGNNCKIGDNVVIDNSYILNNVTITDNCTIKNSFLFSNCNLSPKTLTDTCIISEGVKVPENNYSKCVLEGDKGKIKLVEMTDYLEEDKFVFFKKYTDLDDEDNDNDDNDDDDDSSVLEETSSKRSGQTPDDIPDDTHIFLTEVIDSLLRAYQDKLNCENIILEINSSRYAYNVGIREVTYNVIKGILLLPMHYLGEEKIPVDNANYQKTLKAMINYFTPIILNYVKTDDAQEDCLNAIEEIAGSNEFVMNFAQHLVHLLYDKDVLSEDKIIEWFNENDNDDGFYSEKIRKVLQPFIKWLNEAEEDSSDED</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HN83</accession>
    <name>A0A8J2HN83_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Similar to ralgps1: Ras-specific guanine nucleotide-releasing factor RalGPS1 (Danio rerio)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HICCMSTLAB_LOCUS12029</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5104492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HN83"/>
    <dbReference type="OrthoDB" id="6021951at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007265">
        <property type="term" value="P:Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.840.10">
        <property type="entry name" value="Ras guanine-nucleotide exchange factors catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008937">
        <property type="entry name" value="Ras-like_GEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023578">
        <property type="entry name" value="Ras_GEF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001895">
        <property type="entry name" value="RASGEF_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036964">
        <property type="entry name" value="RASGEF_cat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113:SF368">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113">
        <property type="entry name" value="GUANINE NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00617">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00147">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48366">
        <property type="entry name" value="Ras GEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50009">
        <property type="entry name" value="RASGEF_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ras-GEF" evidence="3">
        <location>
            <begin position="593"/>
            <end position="822"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG5104492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="964" mass="111945" checksum="99CFDFD1A4279B92" modified="2022-05-25" version="1">MEYKRIQKLLLTEYQEFTGRVLVESPFAETTRDGQGLRQVSLGLTSSKFIIASDIIKINSEFICPSELDPAIESFELVSIYPLNYITLSIYRRKRRKTLKARFIDGQINYYELGGTEKKEYYWNLWCKHIRILLSQKDKGSSLSEPSALSSTSTSTLYVLSSSSSSSSSSSCSYSSSSYFHAQTDRKHRKHSTGIDRKSSLCRLWAQYGGAGDGNLSQWSKKDLYLGPSYTELGYGFYTPIINNETTFLRNESDSSTDLIFKTSNNTWPTKTRRKNLTKIQSFHYNDSKNGKRKTRMKKKEYKLITKSSQKVSSISNDTLVPKLSRFKFGIDENCITGLYLEPHYGDPHHLVRVKSAYKLMDPYKFIESGVIVWEKNNFNNGKKHLRRWGLVPTAHFLYALGPWAVTPGDKISIQRKRSSSAVAIRRHSNSKNDFQLQVSKKQLTSSVSLTLLTQLVPSVEINNNSISNNNSKKHFILFWTPDYWYRPKSAITSYRELQNHLINLRDYHSTKKKSNKNFFLRKNTSNSSVDSVKCDKTNCILKKIFSIKDLKNTNNYSYNNNNNNNHHKKNDSINQMRKLLKMNLKITAWDLTSSTIAQQLTLIDRDLFLRISLTEIEILITQKLSKNTPNVRAWIAFSHRVSCLVTSEIIAIKNLNMRARISTRFINAAYKCYSIGNFHSCRSILAGLQSPPIYRLKDTWSRIKTHHSTAYDTISRLSKVFKNTQSKIYERAWSKAENCPPLIPYVGYILIKILKINNYDSLDNLIKCNNNNNNNNNNNNNNNSDMLKQASNKKTQTINWDGGSTFITQQQLQLDKDLNPTKIKQTADNHDYKLKSERKNIVSKILSSFIKTKNFNPIKEKRDEFYWAARQLLLARKYFNRWQTSIITAKIIAQDDQKRNLRNSHNRKNINQLLMWFENCQRHARKYDYPGHSFAWEFILKARYREDKENFFLSKLLEPALDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HNT8</accession>
    <name>A0A8J2HNT8_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS12454</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5106826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HNT8"/>
    <dbReference type="OrthoDB" id="6354412at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5106826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="120" mass="14482" checksum="2FE0609C648C9845" modified="2022-05-25" version="1">MFWRWARFRLRKYFKPIPAAYAQQRKHQLTKIYAFAAWNLFGLTVYSFIRKNYPPTEEEEKDTSRWFIRLLQLENVKRHSMSGFSVQMVDYIKEPGELIVDGQVVVKKKELNEAIYSKLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HP25</accession>
    <name>A0A8J2HP25_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS12833</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5107617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HP25"/>
    <dbReference type="OrthoDB" id="6250964at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013162">
        <property type="entry name" value="CD80_C2-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23278">
        <property type="entry name" value="SIDESTEP PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23278:SF4">
        <property type="entry name" value="SIDESTEP, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08205">
        <property type="entry name" value="C2-set_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ig-like" evidence="2">
        <location>
            <begin position="94"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5107617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="161" mass="18109" checksum="AB24F0ACB77C95A9" modified="2022-05-25" version="1">MHLIEKLHMISGNVNSGIVDARTKGMNDAIHWAASDDLGNRTHFFSGNSHRARLKVKTVKFEDQGIFRCRVDFSNSPTRNFRVNLTLVEQPTRPIIYDAQGREVMGVPRFFEGYDLRLTCQVSGGRPKPTVTWWKDGQLLDGVVDVPEISDISGSSSKFTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HPC3</accession>
    <name>A0A8J2HPC3_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HICCMSTLAB_LOCUS12277</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5106472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6423981at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009653">
        <property type="term" value="P:anatomical structure morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01099">
        <property type="entry name" value="PAN_AP_HGF"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.4.10">
        <property type="entry name" value="Hepatocyte Growth Factor"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052774">
        <property type="entry name" value="Celegans_DevNeuronal_Protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003609">
        <property type="entry name" value="Pan_app"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001507">
        <property type="entry name" value="ZP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47327">
        <property type="entry name" value="FI18240P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47327:SF9">
        <property type="entry name" value="NO MECHANORECEPTOR POTENTIAL A, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00024">
        <property type="entry name" value="PAN_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00473">
        <property type="entry name" value="PAN_AP"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00241">
        <property type="entry name" value="ZP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57414">
        <property type="entry name" value="Hairpin loop containing domain-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50948">
        <property type="entry name" value="PAN"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51034">
        <property type="entry name" value="ZP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035218777" evidence="3">
        <location>
            <begin position="27"/>
            <end position="1398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1267"/>
            <end position="1292"/>
        </location>
    </feature>
    <feature type="domain" description="Apple" evidence="4">
        <location>
            <begin position="30"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="Apple" evidence="4">
        <location>
            <begin position="146"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="Apple" evidence="4">
        <location>
            <begin position="237"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="domain" description="Apple" evidence="4">
        <location>
            <begin position="358"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="domain" description="Apple" evidence="4">
        <location>
            <begin position="823"/>
            <end position="917"/>
        </location>
    </feature>
    <feature type="domain" description="ZP" evidence="5">
        <location>
            <begin position="932"/>
            <end position="1174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="334"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="444"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="511"/>
            <end position="538"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAG5106472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="1398" mass="158325" checksum="2BA432C359452097" modified="2022-05-25" version="1">MKRNFNMFSMVQAITVLTILKMLANAQTTCNGNAGRIVYERLPDQQLQGFDDEVVRDSAPPFRVLEKCQDLCLRDRTAGNNLPRACASFDFQPGSRIASFSGTPEYEESTCYLTREQAQPEGIGNLMLVPNSVHFTEVCLTIERDCPNRRYIFERHPRKKLKLPMTDVREVPAANRTVCEESCLNEYHFVCRSATFDAVNRNCLMSRFTRRTHPELLEDDPNTDYLENTCLNADRRCDGLTVFIKEENRRLRGPFEVDIYTNLTLEECQNLCLRADKYFCRSVEFDEQTRQCVISEEDSVSQKDDIGTSNSPSYHFYDLVCLDNHKCQPNASLQKVASPTARGSEYPDNSVSGHYPDSRRPDTAFQRYRNSRLSGEFHSEITGRSLSECLDECLRQTSFQCRSAVYSEHLRSCRLSRFNQRDGHRIIYDADFDYYENLMHQYLDGDRDNPMYRPDPVGQGTNFEKPSLGRPGHPDDYDKGYPGGSHGDRYPDYYPPPGDRYPSSKYPNQYPDDRYPDKYPDRYPSDRYPLDRYPHDRYPSSGDRYPADRYPVPSDRYPASGDRYPSDRYPVGDRYPGDRYPAGDRYPVGGDRYPVGGDRYPVGGDRYPISGDRYPISGDRYPVNSDRYPMNDRYPVNGDNYPLINTPGYHRYPPPPVYPSSGHRYPSGPGSRYPVKDEPYHPGSGTRYPIPDDPLTRYPTPGINRIPSRYPNDRYPDKDPYPFRDRYPGAYPNGYEDDIRGTKGFADRPGYYSLGGVAGAVRPGPPGAGAGAGAGYPEPSPDNFMAGVGVGGGVGDTDPYNSVRPIGSGGGTIIGRPPLLSRCDEQENFRQVGSHTRVRKPFVRRYTTANTLTECERECADARDFVCRSFNFRAYAAPYGAERDNCELSDRDSRDMAMNNPIYYDTSSDYDFYERNSARQGADGECLDVSQVCSEDGMEFTLRTPDGFIGRIYTYGYYDRCFFRGNGGTVNVLRISGPQGYPECGTQRYGDTMTNIVVVQFSDYVQTGRDKRFNLTCLFRGPGEAVVTSGYIGAGSGSPIPIEYLPAENTLSSRVRLMILYQGRPTTTIAVGDPLTFRLEAQDGYNYVTDIFATNVIARDPYSGRSVQLIDRYGCPVDNYVFPGLDRLREGDSLEARFNAFKIPESNFLVFEATVRSCRDGCQPAYCSGSAGRSEPSFGKRRRRSLNGTTDDVLLDEHEKLFTAKNDTELIEDDEQDDPEEAEEEHVREMIEVLDSRYDMDDNYYSSNVVQKQIAPVETICITPNEYYGLVTAIVGLAVLLSSVVVLSLLIYRKYGYPIIRKNKIVDKVIREDSASSRSNFSFMRSGLPKPFQSTSLSQIFNHQLTSTAMEGAVGLTVNRRSDFDPSEPIYTDPSLFEVSRDSLHQSNSARNENLHLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HPN3</accession>
    <name>A0A8J2HPN3_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase</fullName>
            <ecNumber evidence="10">2.4.1.226</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HICCMSTLAB_LOCUS10606</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
            <location evidence="1">Golgi stack membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the chondroitin N-acetylgalactosaminyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.226" evidence="10"/>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5101704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="431432at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032580">
        <property type="term" value="C:Golgi cisterna membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047238">
        <property type="term" value="F:glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050510">
        <property type="term" value="F:N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.50:FF:000004">
        <property type="entry name" value="Hexosyltransferase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.50">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008428">
        <property type="entry name" value="Chond_GalNAc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051227">
        <property type="entry name" value="CS_glycosyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12369">
        <property type="entry name" value="CHONDROITIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12369:SF11">
        <property type="entry name" value="HEXOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05679">
        <property type="entry name" value="CHGN"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00066811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAG5101704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="1501" mass="175131" checksum="4468E0C4EAF6399C" modified="2022-05-25" version="1">MIFRLECRVSDVETATQHGRWLVFALVYWLVSSRARLCVCLNRNENVAMRTASRPASIQAFGNNFENMTEDKDGFVIVGVMTTQKYLKTRAKAVWETWGREIPGKIIFFSSEESKVPDNCPDLPLVALPKVDDSYPPQKKSFLMLKYMWENYGSKFEWFIRADDDVYIRTDRLKKLLMSVDSGKPMYIGQAGRGNSKEIGKLGLNYDENYCMGGPGVIMTKETMKKIVPHVKDCLGNLYTTHEDVELGRCVKKYAGIPCTWSYEMRSILYHNSSGDQSFTGNLKKREVHQAITLHPIKSPPYMYRLHNYMRALKIQDLQHERIKLHRDIYSMAELLRENVREFIRKPIAENVELFPNSDRENYFGDTLMLEYSLTGLNPRRRIHSDVKEGLEDITREVMASINSCSRQRGRVVEEQSMLYGYRRVDAYGADTILDLLLVYRKYRGREVTLSVRRHVYVHQHFTGIEAREVIEDQEDGDQTRQRNFPNFYSTFLFNFPPSKPEEDPVEDKTVHLVVPLSGRFKTFKRFIKNYEQVCLSTNAKTELLIVLYPHKLEDSVDSTFNLVDSIKLKYENAKIKILLDKDNLFSRAKALDLAIKHLNNEDLVLFIDVDLVFTHEALQRVRLNTVINKKMYFPIMFSQYDPYYVYYFEKSNRDKKKNQFGDLANLSEPMGYWRLFSFGIVSLYKRDYLKIGGFNLSIEGWGIEDLDFYDKSVRSYITVFRAPDVNFVHVYHKITCDEKLSITQKTMCEGSKYETLASKDTLMKIICNGSDYLTFAKKKNRTHSLLINNNNLNSNINENDKEAFGNNFENMTEDKNGLVIVGVMTAQKYLKTRAKAVWETWGREVPGKIIFFSSEESKVPDNCPDLPLVALPKVDDSYPPQKKSFLMLKYMWENYGSKFEWFIRADDDVYIRTDRLKKLLMSVDSGKPMYIGQAGRGNSEEIGQLALNYDENFCMGGPGVIMSKETMKKIVPHVKDCLGNLYTTHEDVELGRCMQSILYHNSSGDQSFTGNLKKREVHQAITLHPIKSPPYMYRLHNYMRALKIQDLQHEKIKLHRDIYSMAELLRENVREFIRKPIAENVELFPNSDRENYFGDTLMLEYSLSDSNPRRRIHSDVKEGLEDITREVMASINSCSRQRGRVVEERSMLYGYRRVDAYGADTILDLLLVYRKYRGRKVTLPVRRHVYVHQHFTGIEAREVIEDQEDGDQTRHRNFPNFYSTFLFNFPPSKPEEDPVEDKTVHLVVPLSGRFKTFKRFIKNYEQVCLSTNAKTELLIVLYPHKLEDSVDNKDNLFSRAKALDLAIKHLNNNDLVFFIDVDIAFTHEALQRVRLNTVINKKIYFPIVFSQYDPNYVYYFDKSNREKKKNQFGDLANLSEPMGYWRLFGFGIVSLYKRDYLKIGGFNLSIEGWGKEDVDFYEKSVKSYITVFRAPDANLVHVYHKVTCDEKLSSTQKTMCKGSRYETLASKDTLMKIICNGSDYLTFAKKRNRIWINFEKIFIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HQL5</accession>
    <name>A0A8J2HQL5_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Cysteine protease</fullName>
            <ecNumber evidence="11">3.4.22.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HICCMSTLAB_LOCUS12730</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Cysteine protease that plays a key role in autophagy by mediating both proteolytic activation and delipidation of ATG8 family proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>[protein]-C-terminal L-amino acid-glycyl-phosphatidylethanolamide + H2O = [protein]-C-terminal L-amino acid-glycine + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine</text>
            <dbReference type="Rhea" id="RHEA:67548"/>
            <dbReference type="Rhea" id="RHEA-COMP:17323"/>
            <dbReference type="Rhea" id="RHEA-COMP:17324"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:64612"/>
            <dbReference type="ChEBI" id="CHEBI:172940"/>
            <dbReference type="ChEBI" id="CHEBI:172941"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:67549"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the peptidase C54 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.22.-" evidence="11"/>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5107400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HQL5"/>
    <dbReference type="OrthoDB" id="2960936at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019786">
        <property type="term" value="F:protein-phosphatidylethanolamide deconjugating activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035973">
        <property type="term" value="P:aggrephagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000423">
        <property type="term" value="P:mitophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005078">
        <property type="entry name" value="Peptidase_C54"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046792">
        <property type="entry name" value="Peptidase_C54_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22624:SF49">
        <property type="entry name" value="CYSTEINE PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22624">
        <property type="entry name" value="CYSTEINE PROTEASE ATG4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03416">
        <property type="entry name" value="Peptidase_C54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11" id="KW-0072">Autophagy</keyword>
    <keyword evidence="4 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 11 13" id="KW-0645">Protease</keyword>
    <keyword evidence="8 11" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Peptidase C54 catalytic" evidence="12">
        <location>
            <begin position="54"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU363115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF03416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAG5107400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="403" mass="45557" checksum="1C327BC8C5AD2477" modified="2022-05-25" version="1">MFSVLDIVNSDIVNKLTMDSLFMQNTSEELDDIPQTHEPVWILGKKYNAMKELETIRRDIKSKLWFTYRKGFIPIGGNSSAFTSDKGWGCMLRCGQMVLAQALIALHLGRDWQWTQETKDSTYLKILSRFEDRRTAPFSIHQIALMGATEGKEVGQWFGPNTIAQVLKKLVVYDEWSSITIHVALDNTLIVNDVLRQCRVEGGTTAVEVDDDEPLRAPSQWKPLLLLIPLRLGLSDINPVYINGLKTSFKLPQSLGVIGGKPNLALYFIGCVDDHVIYLDPHTTQRYGCVNQKLDENDIEMDFTYHCKAASRIPITEMDPSVALCFFCATEKDFKSLCRSMQSELITPEKQPLFELCAERPAHWSPVDDVAAEAFGVASSNLLGFEKLDRQYDTSDEEFELLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HRB0</accession>
    <name>A0A8J2HRB0_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Motile sperm domain-containing protein 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HICCMSTLAB_LOCUS12939</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5107829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HRB0"/>
    <dbReference type="OrthoDB" id="10022288at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000676">
        <property type="entry name" value="motile sperm domain-containing protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039283">
        <property type="entry name" value="MOSPD1/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000535">
        <property type="entry name" value="MSP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008962">
        <property type="entry name" value="PapD-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34441:SF1">
        <property type="entry name" value="MOTILE SPERM DOMAIN-CONTAINING 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34441">
        <property type="entry name" value="MOTILE SPERM DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00635">
        <property type="entry name" value="Motile_Sperm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49354">
        <property type="entry name" value="PapD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="155"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="186"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="MSP" evidence="7">
        <location>
            <begin position="12"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00070425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG5107829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="211" mass="23938" checksum="DC85575188C77C72" modified="2022-05-25" version="1">MHSSRTPRKFPVFVFPQSITFYLDDQSTHKQVLTLYNPYEFPVKFKVLSTAPNKYKVVDPEGTIKSRCCVDIVVRHTALLAANCNVVDKFRIQMQEHPTKQVIGKRDVEAKLLSGVSDPGRRTPDPEMFQQLPLNETRQQRNYSLASQARTIERGTNYIALIAGIVCIIGLLLPTEGEQSLSIPEYLYLSVNFKLILSFVLGLVTIIILRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HRY8</accession>
    <name>A0A8J2HRY8_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Similar to clptm1: Cleft lip and palate transmembrane protein 1 homolog (Danio rerio)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HICCMSTLAB_LOCUS13334</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CLPTM1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5108632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HRY8"/>
    <dbReference type="OrthoDB" id="378564at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008429">
        <property type="entry name" value="CLPTM1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21347">
        <property type="entry name" value="CLEFT LIP AND PALATE ASSOCIATED TRANSMEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21347:SF14">
        <property type="entry name" value="LIPID SCRAMBLASE CLPTM1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05602">
        <property type="entry name" value="CLPTM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="58"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="366"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="407"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="489"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="514"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="617"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="15"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="628"/>
            <end position="637"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG5108632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="637" mass="73941" checksum="C8B5E434DF0DBA61" modified="2022-05-25" version="1">MADTANDGDNRVVANDSSEMENPQENGEVAVVDENQERDINAEIDAQRQKYQPTKWESFLAVLKSLIIRSLVIYFITSFFRRPTADPVSTAASADGAVPKYQAANIFENGTLFDLYVFLSESDHFNNFEDQQALIWKEKGLMYGDWTSGPNNDGTRFFAYKFEPSSQLKRNGSIYLHIYATKTGKSINPKDGKGVYSANQVSYAKKMVNKFKKIKYQKRHNLLTGETTATEEEIKKAEIMDQEIVSHWHPNLTINLVTDQTGWVSGQVPPPLNEYIEFVQGGSFYKPPIYVNDFWNMQRDYFPLNDTVKELELHLTYQPLSLFKWQLYSAQNMRNKWTSSFMGDVADEDDSDQDTLKETILETNPYLLGMTIFVSILHSVFEFLAFKNDIQFWNNRKTLEGLSVRSVFFNVFQSLVVLLYVLDNETNTLIRLSCGIGLCIEIWKINKVVDISLDRSNKILGIFPRVSFRDKGSYVESSTKEYDRLAFKYLSWALYPLLAGYAIYSLMYLEHKGWYSWVLNMLYGFLLTFGFIMMTPQLFINYKLKSVAHLPWRMLSYKFLNTFIDDIFAFIIKMPTLYRLGCFRDDIVFFIFLYQRWIYRIDPTRINEFGYSGEMENASKKQVTVASTKDEASKKTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HTK7</accession>
    <name>A0A8J2HTK7_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Similar to DOCK9: Dedicator of cytokinesis protein 9 (Homo sapiens)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HICCMSTLAB_LOCUS13194</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the DOCK family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5108352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="47328at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08697">
        <property type="entry name" value="C2_Dock-D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13267">
        <property type="entry name" value="PH_DOCK-D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037809">
        <property type="entry name" value="C2_Dock-D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027007">
        <property type="entry name" value="C2_DOCK-type_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026791">
        <property type="entry name" value="DOCK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021816">
        <property type="entry name" value="DOCK_C/D_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043161">
        <property type="entry name" value="DOCK_C_lobe_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043162">
        <property type="entry name" value="DOCK_C_lobe_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027357">
        <property type="entry name" value="DOCKER_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046769">
        <property type="entry name" value="DOCKER_Lobe_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046770">
        <property type="entry name" value="DOCKER_Lobe_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046773">
        <property type="entry name" value="DOCKER_Lobe_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23317">
        <property type="entry name" value="DEDICATOR OF CYTOKINESIS DOCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23317:SF26">
        <property type="entry name" value="ZIZIMIN, ISOFORM K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06920">
        <property type="entry name" value="DHR-2_Lobe_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20422">
        <property type="entry name" value="DHR-2_Lobe_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20421">
        <property type="entry name" value="DHR-2_Lobe_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14429">
        <property type="entry name" value="DOCK-C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11878">
        <property type="entry name" value="DOCK_C-D_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51650">
        <property type="entry name" value="C2_DOCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51651">
        <property type="entry name" value="DOCKER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="5">
        <location>
            <begin position="162"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="C2 DOCK-type" evidence="6">
        <location>
            <begin position="644"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="domain" description="DOCKER" evidence="7">
        <location>
            <begin position="1662"/>
            <end position="2077"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1290"/>
            <end position="1315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1300"/>
            <end position="1310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG5108352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="2106" mass="240817" checksum="F72261BFBA98FF82" modified="2022-05-25" version="1">MSERKFTRALGKPGMAAQLRETVSQVVRESTVQNKPHLVEPIDFESFILKNKTLMQNDPQRELLLYPPDDVSQVVLPRRYRTVQSIVQSILEQSDGGESLLTRECLKNYASNWNVVHYKYAAYSGSYLDLPKLSKGDELREEIYEIDTDVDQVDEEMMKSDGITKEGYLMKGPEIGSSDRMFVNIGSKSFKRRFCHLRQEVDGTYILELFKDEKKGEAKLTIVMDFCTDVVRNPKRGRFCFELRMSGTHKFYTFAADNETDMQEWLLKLSSVLQHYKQQEEKRAASLERTCHTPPPSPIPVQTYGTLKGLDQSMNPQLIKYSRETDTSILLSRRENRKRLFNLYHHLTLGKTQGNLIDGNVDPYKEQFGQRIFIKCETLKFRLQAPIDENESLCQVEPYYTTLSLFDARNGKKLSENFHFDINHEIVRDMVQELSPVSELTDNDKAELPSELKNIPDKWIKYPKQAIFSISNPHPDIFLVVRIEKILQGSICQTSEPYVRATKDPRLGLKVHKNVRACCQRLGNYRMPFAWSARPLFRLYSNELDTSSDFPAIYRQESNKMRDDELLKMLTEYRKPDKLSKLTVIPGWIKLIIEPLAELPENSLTTFLAPLKPFPLPPASNPTFEVSEFESSSEKDVHPYTTYVNHLYIYPQILNFDTQKIFTRARNIACIVELRDNDNENAKPLRCIYGKPGAQILTTRASCTVLHHSAVPSWYEEIKMRLPTKLDNKHHLLFSFYHISCDMNKKKENGVENCVGYSWMLLLHKGKLTVDMENNIQTLPVATDLPPGYLSIQPLGLGKGNAGPDITWIDTQRPIFSVSFQLSSTVFTRDPHLHNLFVHAERILDNKLSGIPSDSETCKILKAAHAIQLVTAITFLPTILNQLFALLTCNPGDEVGLYIIRLLIHIINLIYKAQRKEIIHAYVKFVFMLPSKDTATTTVHEQLAKYLPTLLHPNNTDFLVVNKFMHHSNFFFDIMVKSMAQHMLSSGRIKMHRNERFTKDYHDNIKKLLQVLTPYLMNKYKDMPVETHELNKSLGQFLKKCLTFMDRGFVFSLINDYMDNFSPGEARTLQDFKFTFLQILCSHEHYVSFNLPMMQTRVTSKDLMLEYCLSQDFCKHHFLVGLLLQEIKSSLNEIVQVRKVAIATLRDLLAKHELDDRYQNKGQLSRIAAIYIPFLSVVLENLHRLQSVYETDIKTDLKQNHAAANRLSSSSSSNCLINKDQVNGVAQGDTPKSVHRFTLHLDSQSPIRASMHLRDSTYFAAIAGQGLANGFSCTSIESSTSTLSSTSHSLVSQETTIAREPTENGISEKKGHSRSVSLAQASSRCDKLQSSEMKDLLLCFLFVVKYLGDHQVIAWWQQCSETEIISFFSIIEMSLYHFKYVGKRLIVANSTTTNSGKPKTVKAMTLPARMAPPDFSNDTSGTGTLQPHNTSTRENLVDEDNALNHQALLEANMATEVGLIVLDCLGLFCIHFKDVLLVNDGDNPVMQKLFNIYLSFLQLGQSETLFRHVFASLRAFLNNYSTALFKGNAVFCGRLCYELLRCCNSKLSSIRQESCALLYLLMRSNFEFTNRKGLIRVHLQVIISVSQMLGNVIGLNNSRFQESLSLINSYATSDKVMKGTGFPVEVKDLNKRIRTVLMATAQMREHNNDPEMLVDLQHSLANSYASTPELRHTWLETMARNHARDGNYSEAACCQLHIAALMAEYLKLKKIHSWGAEAFDKISVNISKDERGLKLDAGVQDIHYNESILLEQLESCAEMLEKAERFELLGPLYRLIVPIYENKRNYDALSNCYSHLTQACNKIVEVTKTGKRLLGRFYRVAFFGSVKPKVTSLPEISERLHRLFAEKFGVENVKMIMDSAPIKLSDLDQKMAYIQVTHVTPYFEKLELESRLTEFEQNHDVSCFMFETPFTHEGKPRGNPEDQWKRRTIITTQYSFPYIKKRIPIIEKKIIELTPIEVALDEMRQRVQELEDVALLAPTDVKKLQLRLQGSVCVTVNAGPLTYASAFLDPALSPQYPDDKVEELKDVFRDFIKICYTALQINSKLITSDQHEYQEVLRENYQKLCQNLSSLLGESIWPDDQVGSFKRNSAALFSAISGANNHTSIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HUB3</accession>
    <name>A0A8J2HUB3_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS13818</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5109182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HUB3"/>
    <dbReference type="OrthoDB" id="7682789at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="434"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="99"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="445"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5109182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="669" mass="75906" checksum="68B167267D2F6E04" modified="2022-05-25" version="1">MDPELQKMYQLQPLTASLSDLQGRCSFQQASPRKKHPRIAEINCGDRPGISALTNPDKRRREELRIKSRVIIDRTKYIEQWLQAHESVQKNNLTTSNCSSPSSVSSSVVYGSPPQLIRSSKKTPRSPLKDCNQLKRFKSNDSEKLNAQIRLNYSPVKNKAKENQVNNKSSPKKFSKYKKNIVDQYEENLNIESCLSPISVNPADDSPLEIMELNSPAPSSLFLESVHSDCNSPQVEEIQSISSPRITQECINIDESDTSVVCDENLPNLNLTILSDSNKTISDLVGDLDGSLVDIDEIQSEHSHSRRSLNHTIDSDETFFSEVENADRTVIANNIDCDDKSEDERYKKVVIDDEDDSEFSHVSENELVISEFTSQSVINGDSTKEVLSIEETSDLQEKKIVKINCKTVENEPVEEISHASSQKISQDYLTPPPEVQGNTTDLDNIISISDSPPSRQSSRIERDTFVRTVVKKKKKKKPKKGSLVERLQTLVSRKISSIRIWRHQMSQDHLKTNSPCVTVQINECTWRYSRYIIDGKIIKDDNDLIGRSVRENSLLDKSVTVDGSNKNLLSSIKLLLVPEIVGKINFEGKNIIKVYPPWDIVDFNQVFLNIFHFIVTVDSNVTNHENLGRKMKLVKEFKCPCLTEKKLSESCGDKFKSSKTNFMQYLFQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MBI9</accession>
    <name>A0A8J2MBI9_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Mitochondrial (Mus musculus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HICCMSTLAB_LOCUS3382</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5081803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MBI9"/>
    <dbReference type="OrthoDB" id="2962993at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031956">
        <property type="term" value="F:medium-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05941">
        <property type="entry name" value="MCS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43201">
        <property type="entry name" value="ACYL-COA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43201:SF8">
        <property type="entry name" value="ACYL-COA SYNTHETASE FAMILY MEMBER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="2">
        <location>
            <begin position="56"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="3">
        <location>
            <begin position="466"/>
            <end position="541"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG5081803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="557" mass="62027" checksum="63B55137AE2A2901" modified="2022-05-25" version="1">MGSLLRRSFYSSAYGIARCQKNNLIVRRLQQTHAALSSINETHEPPRNNNVVPIFRNAIKFGDKTALRDLQGYYTYRGLFLSSRQFAGELSNILKEGQQERIAFLMPNDARYVIVQWACWMSGQIGSKVVITTTEFAPLLEPIASKCNCRLIVLDNALRLLAMKPLPRLANNRDTDVEYFDESSETPLKDEFYNDSDAMFVYTSGTTGTPKAVVLTHKNLQSQMNALISAWKWTDKDIVLHTLPLNHIHGIVNVLMCPLYIGARCVMLPKFETSSVWAQLLAVNLQNPERVNVFMAVPTIYMMLIQEYEQLFSKNPKIREYVHTVCKITGHRLLERYGMTETGMVLSNPLEGQRIPGTVGTPLPGVQVRITGPSSTPEVLVQGSSSGSKVVGKEAKIPVSGDLQVKGESLFREYFNKPEATAKEFTSDKWFKTGDTAMYDGNVYSILGRSSVDIIKTGGYKVSALQVETVILGHPDIIDCAVVGLPDITWGQKVAAVAVTREGSEILLHQIREFAKKSLPDYAVPTVLKIVDKIPKNNLGKVNKPNLLAAVFPNNKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MG65</accession>
    <name>A0A8J2MG65_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Vacuolar protein sorting-associated protein 72 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HICCMSTLAB_LOCUS2956</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the VPS72/YL1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001117">
        <property type="protein sequence ID" value="CAG5079215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MG65"/>
    <dbReference type="OrthoDB" id="78296at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013272">
        <property type="entry name" value="Vps72/YL1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046757">
        <property type="entry name" value="YL1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13275:SF4">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 72 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13275">
        <property type="entry name" value="YL-1 PROTEIN TRANSCRIPTION FACTOR-LIKE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05764">
        <property type="entry name" value="YL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08265">
        <property type="entry name" value="YL1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00993">
        <property type="entry name" value="YL1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Vps72/YL1 C-terminal" evidence="4">
        <location>
            <begin position="317"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="187"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="258"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="36"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="103"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="197"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="260"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAG5079215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="399" mass="46640" checksum="8912B513CD0C0353" modified="2022-05-25" version="1">MASSREKRANAGNKMAKLLNEEEEDDFYKTTYGGFEEVEQDNDYMEEDEGEDEVDSDFSIDENDEPVSDPEQEGPKKKRRLVTKAYKEPKPVTTQPKAVTKEKKPRIIKRRKFSNDSTGRKSIRRSTAAKSAATQKRLKERNEDQRRKVKKVRHDVWKPTQEELLEEALETEEINLKSLEKYQKLESEKKNTRTVRKTQSQPMIRYQSLSMPIMVLSDSRDKESEKINIDGDDEVKPADDFNTNTVSDTPVSIQYVLETTNDKGENDTKKSDEKKTSKQEIAQSKGYYERTFITFESERQFLKAFRKTPAPRRTLRSLCAITRLPAKYRDPVTNLPYRNIQTFRLLREAYYQQLETKVDTSDTTNNADLIRWLEWRQKNQHAVQKSTVRLESASIYSTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MGI4</accession>
    <name>A0A8J2MGI4_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Similar to rg: Neurobeachin (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HICCMSTLAB_LOCUS2760</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001117">
        <property type="protein sequence ID" value="CAG5078499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MGI4"/>
    <dbReference type="OrthoDB" id="26681at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008104">
        <property type="term" value="P:intracellular protein localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06071">
        <property type="entry name" value="Beach"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01201">
        <property type="entry name" value="PH_BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1540.10">
        <property type="entry name" value="BEACH domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000409">
        <property type="entry name" value="BEACH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036372">
        <property type="entry name" value="BEACH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050865">
        <property type="entry name" value="BEACH_Domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046851">
        <property type="entry name" value="NBCH_WD40"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023362">
        <property type="entry name" value="PH-BEACH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13743">
        <property type="entry name" value="BEIGE/BEACH-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13743:SF162">
        <property type="entry name" value="NEUROBEACHIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02138">
        <property type="entry name" value="Beach"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20426">
        <property type="entry name" value="NBCH_WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14844">
        <property type="entry name" value="PH_BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01026">
        <property type="entry name" value="Beach"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81837">
        <property type="entry name" value="BEACH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50197">
        <property type="entry name" value="BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51783">
        <property type="entry name" value="PH_BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="BEACH-type PH" evidence="5">
        <location>
            <begin position="1"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="BEACH" evidence="4">
        <location>
            <begin position="115"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="658"/>
            <end position="689"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAG5078499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="746" mass="84902" checksum="ACC8E0E3CA4EB1D6" modified="2022-05-25" version="1">MLQWSIKKSFLSITVVDLAQLRLCYHGFSLWFPHGFVLKYCDHLHGKWYFSEVRAIFSRRYLLQNVAIEIFLASRTSILFAFPDQMTVKKVIKALPRVGVGIKYGIPQTRRASMMSPRQLMRNSNMTQKWQRREISNFEYLMFLNTIAGRTYNDLNQYPVFPWVLTNYETKELDLSLPSNYRDLSKPIGALNPSRRAYFEERFQSWDNDSIPPFHYGTHYSTAAFVLNWLIRVELIPEFFFLPEMLVNSNRYRLGRQEDGSSVGDVELPPWASSPEEFVRINRMALESEFVSCQLHQWIDLIFGYKQRGPEAVRATNVFYYLTYEGSVELESIVDPVIREAIENQIRNFGQTPSQLLMEPHPPRSSAMHLSPMMFSSIPDDVCMTIKFPSNSPICHISANTYPQLPLPSVVTVTTGQQFAVNRWNTNYAASVQSPSYADTPQAQAINQPLSMDPVLSQTANSSNPALKRHLGDNFSQKLKIRSNCFVTTVDSRFLVTCGFWDNSFRVFSTETAKIVQIVFGHYGVVTCLSRSECNITSDCYIASGSADCTVLLWHWNARTQTIVGESEAPAPRATLTGHEQPVTAVVISAELGLVVSGSYYGPVLVHTTFGDLLRSLEPPSGFISPENIAMSREGVIVVNYERGHIAAYTINGKRLRHESHNDNLQCLLLSRDGEYLMTGGDKGIVEVWRTFNLALLYAFPTCEGSVRSLALSHDQKFLLAGFANGSIVIFHIDFNRWHHEFQQRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MH64</accession>
    <name>A0A8J2MH64_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Glutaredoxin-2, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HICCMSTLAB_LOCUS5986</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="4">Glutathione-dependent oxidoreductase that facilitates the maintenance of mitochondrial redox homeostasis upon induction of apoptosis by oxidative stress. Involved in response to hydrogen peroxide and regulation of apoptosis caused by oxidative stress. Acts as a very efficient catalyst of monothiol reactions because of its high affinity for protein glutathione-mixed disulfides. Can receive electrons not only from glutathione (GSH), but also from thioredoxin reductase supporting both monothiol and dithiol reactions. Efficiently catalyzes both glutathionylation and deglutathionylation of mitochondrial complex I, which in turn regulates the superoxide production by the complex. Overexpression decreases the susceptibility to apoptosis and prevents loss of cardiolipin and cytochrome c release.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Monomer; active form. Homodimer; inactive form. The homodimer is probably linked by 1 2Fe-2S cluster.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the glutaredoxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5092224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MH64"/>
    <dbReference type="OrthoDB" id="418495at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015038">
        <property type="term" value="F:glutathione disulfide oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03419">
        <property type="entry name" value="GRX_GRXh_1_2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000026">
        <property type="entry name" value="Glutaredoxin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002109">
        <property type="entry name" value="Glutaredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011899">
        <property type="entry name" value="Glutaredoxin_euk/vir"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014025">
        <property type="entry name" value="Glutaredoxin_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02180">
        <property type="entry name" value="GRX_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45694">
        <property type="entry name" value="GLUTAREDOXIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45694:SF5">
        <property type="entry name" value="GLUTAREDOXIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00462">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00160">
        <property type="entry name" value="GLUTAREDOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51354">
        <property type="entry name" value="GLUTAREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0318">Glutathionylation</keyword>
    <keyword evidence="3" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutaredoxin" evidence="7">
        <location>
            <begin position="27"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00037470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00039819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG5092224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="109" mass="11883" checksum="FCFE5AA375CCD295" modified="2022-05-25" version="1">MGLVSSSRRIMTIDKVAVQKIIDSDTVVIFSKSTCPYCTKAKNAFKQLGKDFKVIELDQEDDCAGYQDALGEITGARTVPRVFVNGKFIGGGDKVAEMLKTGELAKLFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MHK4</accession>
    <name>A0A8J2MHK4_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DNA ligase 4</fullName>
            <ecNumber evidence="4">6.5.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">DNA ligase IV</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">Polydeoxyribonucleotide synthase [ATP] 4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">HICCMSTLAB_LOCUS3883</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>ATP + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)m = (deoxyribonucleotide)n+m + AMP + diphosphate.</text>
            <dbReference type="EC" id="6.5.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 19">Belongs to the ATP-dependent DNA ligase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="23">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.5.1.1" evidence="4"/>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5083601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MHK4"/>
    <dbReference type="OrthoDB" id="151490at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032807">
        <property type="term" value="C:DNA ligase IV complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005958">
        <property type="term" value="C:DNA-dependent protein kinase-DNA ligase 4 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003910">
        <property type="term" value="F:DNA ligase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071897">
        <property type="term" value="P:DNA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006297">
        <property type="term" value="P:nucleotide-excision repair, DNA gap filling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07903">
        <property type="entry name" value="Adenylation_DNA_ligase_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07968">
        <property type="entry name" value="OBF_DNA_ligase_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3260.10">
        <property type="entry name" value="DNA ligase, ATP-dependent, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.30">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044125">
        <property type="entry name" value="Adenylation_DNA_ligase_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000977">
        <property type="entry name" value="DNA_ligase_ATP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012309">
        <property type="entry name" value="DNA_ligase_ATP-dep_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012310">
        <property type="entry name" value="DNA_ligase_ATP-dep_cent"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012308">
        <property type="entry name" value="DNA_ligase_ATP-dep_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036599">
        <property type="entry name" value="DNA_ligase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029710">
        <property type="entry name" value="LIG4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00574">
        <property type="entry name" value="dnl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45997">
        <property type="entry name" value="DNA LIGASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45997:SF1">
        <property type="entry name" value="DNA LIGASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00533">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04679">
        <property type="entry name" value="DNA_ligase_A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01068">
        <property type="entry name" value="DNA_ligase_A_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04675">
        <property type="entry name" value="DNA_ligase_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117018">
        <property type="entry name" value="ATP-dependent DNA ligase DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56091">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50160">
        <property type="entry name" value="DNA_LIGASE_A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="20" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="10" id="KW-0227">DNA damage</keyword>
    <keyword evidence="13" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="14" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6 23" id="KW-0436">Ligase</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="ATP-dependent DNA ligase family profile" evidence="21">
        <location>
            <begin position="351"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="22">
        <location>
            <begin position="831"/>
            <end position="892"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="20">
        <location>
            <begin position="780"/>
            <end position="807"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00030676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00031942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00034003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU004196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="CAG5083601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="893" mass="102906" checksum="16F1FA5558B4ABEA" modified="2022-05-25" version="1">MVSLASKIEFNEFCNLLEEILSASPKNKVKILTDFLNKWREVGKELKNENPDADISLFPIMRLLLSSKDHERGPYGLKEKSLGILYVRVFCLGNSDDAKQIINYREPTEQKTPSGGDLAGKIYWILKRRQTKNICKLSIEQINSLLDKIAEKNRQNKSKDPEFFRMAQQCSALEIKWLTRIILKSIRIGIGEKQILNAYHPDAESLFGEQSNLREVCDTLHNLKYRPKKTCNISVLSPFKPMLLEGFYIERISELFTTTPSYIIQTKFDGERSQLHMSNGKFKYYTRHGYDITNHPSFGDSPLSGNLTSKISSLLNPECRSIILDGELMGWHKEKLCFGSKGMNFDVKKLTSKSVHQPCLMAFDIILYNDKLLVDLPLKERLKVLESAFTPQDGVLMRSNNTIVSSPDQIREIFNQSLDNYDEGIVVKDSLGIYKPNSREGNKCYKIKAEYSDNLVEDIDLLIVGGYYGQGKYSGMYNSFLVALVVPGPSEETRKFQSVVGVSSGIPRDKLRDLNARFAESWTKERPSCVVGPSKDPPDSWLPPEKSTVLQIRASELIKCKTQPTGYTLRFPRVKKVREDKPWYDACTITEFNNLIKHRGVVNKLTKRHATEEDEKCLPAKRRDTEAKFIKSIKMDEKHFGVRAADVQRKTRLMEGKEFCVINGDGKVSKEDLERILLEHSAKVVQNPGRNTFCVLIGDEKILKARNLIECAKYDVAKISWVIRATKEENWGRLVEFLPWEMLAMRKETRDRLKVMFDEYWDGFFVDADLESLKRSLERAEDLEDCRAFEEEDYKELEEECGDLQVRVFENVAGHFVKDDWLKKPFVFLRGKICEEIDGSTTHVFVGGNWDRESVYRKINQSGKNFIKVLDKKWVRECLDRGRLLPENDYIVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MK81</accession>
    <name>A0A8J2MK81_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Cc_odve66_7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS3340</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5081634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MK81"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5081634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="479" mass="54761" checksum="1A33124AE3F866AB" modified="2022-05-25" version="1">MNGDLDSQIETKAEKRDILDREISRKVLTNIDLDSQIIKKTGEYTRLKNLVVEKTQASKTIDVQIQKKDNKYNRLDGKILEKTKINDDLDSQIKTKADKRDLLDREISVKTQANDDLDSQIIEKTKECTRLENLVLEKKHISKTVIIQIEKKNKEVSLLDADVNKKLEVLKMLNHSIDTKLQQTTSADLTKLFEIKEKLRSLSSFTPDLSLDEEHAVDVYDSDENLPSQYRPSSNVVGMKNLSELGIKLLRKINSGSISSSNKYQKCFNFIVQQVSNYGGTTNIDVDSIISLTTFLSMYMLVYSEDLPDKSRYHSIITKLIPRIPSIPIPELTSGNSKKEYSAILNLSTPRLLSNYINNFNDYIHDINSIALSKFNSKINSVDGVAFSDHIRQDSSAFAVHSERHVPYVNYSIYLKKVVEVMKFPDLYASVYSVLDIPGNFYDSVRRIVTTIMHPTIKVLQHGLNTTDGKIKFKFKWYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2ML42</accession>
    <name>A0A8J2ML42_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Cc_bv10.1_29.18_pseudo</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS6136</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5092432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2ML42"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5092432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="22" mass="2476" checksum="8DC9C1BAA3F151F8" modified="2022-05-25" version="1">MLLVSQRKSDLQICGLLCCHSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2ML80</accession>
    <name>A0A8J2ML80_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS6094</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5092375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2ML80"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5092375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="87" mass="10265" checksum="820B15E7158CE6CE" modified="2022-05-25" version="1">MNVIQYNYQYVKGYQLHLIENFKQKGLSFLCIPGSQPSQLCHIEQLAMKNKKGRRQPRSTVGLRNSSDHVFQENRFRLTRRHSGNIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MLW9</accession>
    <name>A0A8J2MLW9_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Similar to Ankrd28: Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A (Mus musculus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HICCMSTLAB_LOCUS6511</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5092996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MLW9"/>
    <dbReference type="OrthoDB" id="6593077at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050889">
        <property type="entry name" value="Dendritic_Spine_Reg/Scaffold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24166:SF48">
        <property type="entry name" value="PROTEIN VAPYRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24166">
        <property type="entry name" value="ROLLING PEBBLES, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="27"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="17"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="19"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="49"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="82"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="149"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="183"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="216"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="249"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="282"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="316"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="349"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="416"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="449"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="523"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="603"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="636"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="670"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="739"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="879"/>
            <end position="912"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="916"/>
            <end position="948"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1005"/>
            <end position="1037"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="555"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="555"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="577"/>
            <end position="587"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAG5092996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="1097" mass="117619" checksum="BB97FB44EB8F1836" modified="2022-05-25" version="1">MGYLKIDFTFIELINLQPPLLQAIFLGDIQEVRSLLATQQESVHWKDEKLRTLVHAAAFIGDPEILEALILSGAGVNKKDKHWLTPLHRACCSGNVAAVEVLLKHDAAVNIRDTTWRTPLHVAAANNAVECARLILPKLFKNINLMDRRRRTCLHYAASNGHLEMTRLLLEQPGCAINARDKEDRCALHYAVSEGHEEIVKILLEHGAEVDVKDRNLYTPLHVSVAAGKFGCLKILIEAGADIEAKNSYGNTPLHVACLNGHAAAVAVLVYHGSNIEAVNYRGQTPLHIAAASTQGVSCLEILLSAGADINVQSQDGRTPLHMTAIHGRFTRSKSLLDAGASPDTRDKNGNTALHIAAWLGHECLTTTLLECGASPAARNAEQRTPLHLSCLAGHIEVCRKLLQVDNKKIDSRDICGRTPLHSAAFKGSVDCLDLLLSSGANFRLSDNDNRLALHYAANQGHYLCVFTLVGYGSDPNAQDVNGATCLHLAAGSFSVIHSGDYAGECVRYLLTHRADAHIRDKRGFTAIHYAVAGGNQSALEALLNVSATVISNNQSSTLTNSKSSQPSPPIRCENISPASPGSSTPSSVNLTAASLIQGPGNPALTPLHLAAFCGHGEILRLLLPLFPSTNIREDTGKTPLDLAAYCGHEQCVRLLLRCAALVSVQDNVTKRTPVHCAAAMGHADCLKLLLNNMEDPSVIDRYDIKHRTALTLAVANEHTKCAAILLEYKADCNLPDINKHTPLFRAVIQVQYNPDPVLDQLLRHGARVSVQDNSGKTPVHLAAAAGGLYALEALLKADPSAVSLKDDQGCTVLHWACYNDHSDCVEYLLQQNFVDTLESNPLSAVHCAVHQGSAECLKLLIDKFGGKAVAAAPRDNPGGRLPLHVAAASGSVECAKLILHSVGANLAGLEAQDYAGRTPLLSAALAGQTATIELLLEWKANIQAVDAGNNTALHLACQRKHSQAASLLLDIIESSQTVPLINSTENSQKNPSKRVEIVNMANKQLKTPLHFAAKNGLVGITRRLIQLGASIVAVDLDGLTPALACAPNPAVAKCLATILAAHGQNLESTQQPSIQQTSEIYLNGKDSQHSSDSEFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MMS9</accession>
    <name>A0A8J2MMS9_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Serine/threonine-protein kinase ULK3</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Unc-51-like kinase 3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">HICCMSTLAB_LOCUS9088</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="16">Belongs to the protein kinase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5099486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MMS9"/>
    <dbReference type="OrthoDB" id="346907at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005776">
        <property type="term" value="C:autophagosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034045">
        <property type="term" value="C:phagophore assembly site membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010506">
        <property type="term" value="P:regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042594">
        <property type="term" value="P:response to starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061709">
        <property type="term" value="P:reticulophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000042">
        <property type="entry name" value="Aurora kinase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000804">
        <property type="entry name" value="Blast:Serine/threonine-protein kinase ULK3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.80">
        <property type="entry name" value="Phosphotransferase system, lactose/cellobiose-type IIA subunit"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045269">
        <property type="entry name" value="Atg1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007330">
        <property type="entry name" value="MIT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036181">
        <property type="entry name" value="MIT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24348">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE UNC-51-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24348:SF65">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE ULK3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04212">
        <property type="entry name" value="MIT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116846">
        <property type="entry name" value="MIT domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 15 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0072">Autophagy</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 18" id="KW-0418">Kinase</keyword>
    <keyword evidence="8 15 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 16" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="17">
        <location>
            <begin position="9"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="38"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00032242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="CAG5099486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="411" mass="47117" checksum="0351531B7CB8B54A" modified="2022-05-25" version="1">MALPKLDDYIIIEKIGTGSYATVYKAVKKDNRSVVALKCVDSSTLSKSAIDNLITEINLLKVLKHEHIVEMKDFFWGEGRIYIVMEYCDAGDLSTFIKRKHKLPEKVCHKFLQQLALALKYLRSNNVCHMDLKPQNLLLIRKPTLRLKVGDFGFAQYLSTDEHKFAIRGSPLYMAPEILLRREYDARVDLWSVGVIMYECLFGKAPYSSNTFEELAEKIKSCRPIEIPKGSCVSHECKDLLQSLLKHDPEERISFDNFFAHEFLDLEHAPTQENYEKAVALIQCGVKEDMEKNYQQAFQLYCNALRYFIPILMGSLSKSTFDMASGLEMGEIGEQYFAEGNYSLALEKYKACLGILVRVLSKEPPGKRRELLHKQIQIWMKQAECTKGLLATKDMQETIKSAETTDQCRLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MNH0</accession>
    <name>A0A8J2MNH0_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Isoforms A/B/D/L (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS8908</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5097849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MNH0"/>
    <dbReference type="OrthoDB" id="10004641at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="29"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="59"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5097849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="108" mass="12653" checksum="4D5868D6273B6434" modified="2022-05-25" version="1">MHVKLANFLNEVGEPVRYECLDNAPTKKFVCPNLCGSSFSHNYSLTRHLKYECGQEPRFKCPYCDLHYKRTSNVTQHIRTRHVNCTTYAIDIIDNKIVGIHFTEKKKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MP25</accession>
    <name>A0A8J2MP25_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase</fullName>
            <ecNumber evidence="5">2.7.8.15</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">GlcNAc-1-P transferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">N-acetylglucosamine-1-phosphate transferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">HICCMSTLAB_LOCUS9045</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="17">UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase that operates in the biosynthetic pathway of dolichol-linked oligosaccharides, the glycan precursors employed in protein asparagine (N)-glycosylation. The assembly of dolichol-linked oligosaccharides begins on the cytosolic side of the endoplasmic reticulum membrane and finishes in its lumen. The sequential addition of sugars to dolichol pyrophosphate produces dolichol-linked oligosaccharides containing fourteen sugars, including two GlcNAcs, nine mannoses and three glucoses. Once assembled, the oligosaccharide is transferred from the lipid to nascent proteins by oligosaccharyltransferases. Catalyzes the initial step of dolichol-linked oligosaccharide biosynthesis, transfering GlcNAc-1-P from cytosolic UDP-GlcNAc onto the carrier lipid dolichyl phosphate (P-dolichol), yielding GlcNAc-P-P-dolichol embedded in the cytoplasmic leaflet of the endoplasmic reticulum membrane.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>a di-trans,poly-cis-dolichyl phosphate + UDP-N-acetyl-alpha-D-glucosamine = an N-acetyl-alpha-D-glucosaminyl-diphospho-di-trans,poly-cis-dolichol + UMP</text>
            <dbReference type="Rhea" id="RHEA:13289"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19507"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="ChEBI" id="CHEBI:58427"/>
            <dbReference type="EC" id="2.7.8.15"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="18">
            <dbReference type="Rhea" id="RHEA:13290"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the glycosyltransferase 4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.15" evidence="5"/>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5099401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MP25"/>
    <dbReference type="OrthoDB" id="10262326at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003975">
        <property type="term" value="F:UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006488">
        <property type="term" value="P:dolichol-linked oligosaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06855">
        <property type="entry name" value="GT_GPT_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000715">
        <property type="entry name" value="Glycosyl_transferase_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033895">
        <property type="entry name" value="GPT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10571">
        <property type="entry name" value="UDP-N-ACETYLGLUCOSAMINE--DOLICHYL-PHOSPHATE N-ACETYLGLUCOSAMINEPHOSPHOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10571:SF0">
        <property type="entry name" value="UDP-N-ACETYLGLUCOSAMINE--DOLICHYL-PHOSPHATE N-ACETYLGLUCOSAMINEPHOSPHOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00953">
        <property type="entry name" value="Glycos_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 19" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="60"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="96"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="127"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="164"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="200"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="224"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00017659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00029567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00033238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00044717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00045078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="CAG5099401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="244" mass="27736" checksum="4EF9BF9E3997FCFB" modified="2022-05-25" version="1">MEESEKTWKMNFSLYINILMSIFGFIVAIILIPSFKDKFIKANLFGIDMNKRNGGKVPEALGVVSGCIFLITLFLFIPIPFTDNIFDNSTFPHHEFVELLAALLSICCMLLLGFVDDVIDLQWRYKLLLPTIASLPLLMIYYVNYNGTLIIVPKPLRCWFGLSVNLGLIYYVYMGMLAVFCTNAINILAGINGLEVGQSLVIALSIIIFNIIELIGPLWKAHQFSLYLMLPYFTTSLALFKYNW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MPL4</accession>
    <name>A0A8J2MPL4_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS4644</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5087915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MPL4"/>
    <dbReference type="OrthoDB" id="6077919at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="25"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5087915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="431" mass="49571" checksum="B4CAF3A6F7E7A977" modified="2022-05-25" version="1">MSANKRRKISSSWEVRDGPRTRSRTFTLETLPPEVLEMVFKYLPCQVVATSARLVSRQCQLVATSVLNGAFISAGHRLEAAMLRTEARISQLKNETDVLAHSRAFNILELIRSQYKMLRAVTWRYTHPPRPEKFPRLCFYAGSLLDELNNLLYLANVRPAALIGPNGPDAVVTAFFALCKRFMNYFEKVSERKLNRSALVSGCKAIDILDCLAEGRRVVGFRLTTGRGNRGSILCMQLRYVMRRAWFTCLEVPRAVDETSWRDEQRFMHLRLRRLVGSVNEHHYEAVHHDRERLMHTKRMPLPRIPVSSTYSGYGEYGGQFFYYGNMNRSAFANKFHLAPESEDYEADDRQNSRGISKFDLTISVDLRCSPELAPFLVRSILKSDDFDHPRASHNPEIYMKMKVSCPGSVANRLPGNFIWEQKACKRSHSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MRL2</accession>
    <name>A0A8J2MRL2_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS5717</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5090681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MRL2"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="155"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="192"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="647"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="667"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="698"/>
            <end position="718"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5090681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="870" mass="98484" checksum="141EE36D0999E068" modified="2022-05-25" version="1">MYVLVLYQDEIWHVCPLKNVSTVRKKCMVKYSDNKKYAARVMAICHDKMILTGIMKNIHGTTNHMQGVWELENIPSKSFSQVSKDFSKDVKEHVLFIDENLFKKSLSDNLIQCFNFDQDINIYKFVLKQPRFKRIKRVNEENTSQESMLKSMAKNLSDDEISPTSADKCSPSKIIRNDDDKIQESMSKSMAKDFPDDEIPPISANECSPPKVTVNDENTSQESMLKSMAKNLSDDEISPTSADKCSPSKIIINDDDTIQESMSKSMTKDAPDDEIPLISADEYSPSKVKSLDAPSDFSKFSPSNLHTEQKNRCIEEPKMLAKTNIIQSNIVEDESLSVTIDKSLQLNPPILEAASNFLILQAIGNPTFNSTLKEGCNPVVICSSDAEQKENSIRYLNIPEKLCIVDPSIDHGTNLLSAISGPRPSEFLISHDSPELQATGQLILINNVQEGLSLLNLSHSDVQQKCQGQLESKFSIDQSSTEEKIFVNLSEISHKQTIESSGYDKTYTVHESDNPKNCNELHQIFNGTLQNTIQGSFIELTEEPINHSLLDLNLEISQLSQVLKLNNGISKFSLINNEVNLPKYHTLEQGIANSHGINGQTIARITEKTTISENIEPEKDNSKEKIKPKIVSEEKVCIKLPKKRKYDDTNSGLQNLETKMKRRKQKKEIEREAKENEEKEPEEEDKAARGVESYFGESGDDEDEYKPDSNEESSESEYDENHEFQDDDELDADLRTEQTFSDSLNDTITVDQNSKALRLLGRLLVAIKSLNSHITSFTHIFQPRHYDFLIEAVKKVASRINQSSLKFDNSAPKTWTDEAKSTVLSAFKRHLENGNVPSGKEMQELINTHDCFKGRSVPQMRSWLHTYKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MS95</accession>
    <name>A0A8J2MS95_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Similar to su(W[a]): Protein suppressor of white apricot (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HICCMSTLAB_LOCUS11573</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5103565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MS95"/>
    <dbReference type="OrthoDB" id="5836667at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000395">
        <property type="term" value="P:mRNA 5'-splice site recognition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22249">
        <property type="entry name" value="UDM1_RNF168_RNF169-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.790:FF:000002">
        <property type="entry name" value="Splicing factor 3A subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.790">
        <property type="entry name" value="Surp module"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000061">
        <property type="entry name" value="Surp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040397">
        <property type="entry name" value="SWAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035967">
        <property type="entry name" value="SWAP/Surp_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019147">
        <property type="entry name" value="SWAP_N_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13161">
        <property type="entry name" value="SPLICING FACTOR SUPPRESSOR OF WHITE APRICOT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13161:SF15">
        <property type="entry name" value="SPLICING FACTOR, SUPPRESSOR OF WHITE-APRICOT HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09750">
        <property type="entry name" value="DRY_EERY"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01805">
        <property type="entry name" value="Surp"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01141">
        <property type="entry name" value="DRY_EERY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00648">
        <property type="entry name" value="SWAP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109905">
        <property type="entry name" value="Surp module (SWAP domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50128">
        <property type="entry name" value="SURP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="SURP motif" evidence="9">
        <location>
            <begin position="259"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="SURP motif" evidence="9">
        <location>
            <begin position="488"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="208"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="314"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="377"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="603"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="701"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="556"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="218"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="322"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="603"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="649"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="701"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="729"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="785"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="812"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="835"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="868"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAG5103565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="878" mass="98936" checksum="11260C365F704F96" modified="2022-05-25" version="1" fragment="single">FISTVMASKNHRWLVDSGILRKKNNEEEPQELLVFGYSCKLFRDDEKAKMIDHGKHLIPWMADNALKIDRCDPSAGQLLPGAGHPGQVMNGLLVSLSIFKKYPCCRRTSLQQGERQGRESIDSRELYDGRGALADLRVHEPPSGGFDARTILTEDELKIEQLCDEERYRSLYNNDAEELMYHEEEMKRLHQALGSDNTYGQVAYNYDDQDNQIGVGDDSQSPKPSDGSQDDDDQAFTLPPELEAPEGMVMPETQKLNAIITKTALFISRQGSQMEILIKAKQSNNPQFAFLSIEGALHPYYKLVLDAIKQGKYNPEKLPEKEESESDEESDENDEPYLHPSLASSLTKVEAAPSIPSIQYKPSADCAYSMLVNKITGKPPQSKNPPFSPELPAQQVPPSEYCPPVSSQNYAAYPLTPQQYSHGPVIYGPNGQAQQPSMAFMSTASVPDAPSTPVIKEPPAPLVPYGPTPPKPLSRPSFIVPPADVQIIIDKMASYVAKNGRDFEAIVKAKGDARFNFLELSHQYHGYYAHKLTIYEGGVNPKVLTEEELLRKQEPQEEKQKRLEEIQKKQQRMEEVQKRVKMIQAKKKSEKQITTVSFSIKKPKDSDTTVMEKRSALPMEESDDEKDDKDEKKDSSSKSNSPLFVLGEENSSSKQNKEMTTSNNETEERDFVDLTDDILEDCRSQVKHKSLETKIKDKLAAAARDKLASSSREKQLQLERKKKAAMFLSQIQAPALSKSNIEMRTEDDLDEVHSIPSPTPEEVEDSRSRNSSLMSRLKSADLGVKRSRPKSPSRSRSASRSRSRSRSYSDRHKYHKKHKKKKSSHRSYDSPSASRSHRAKKSKKSTSRHRSRSRSSGRRSTRHSRNPNDSNDSDSNSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MSF0</accession>
    <name>A0A8J2MSF0_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Similar to CDAN1-interacting nuclease 1 (Xenopus laevis)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HICCMSTLAB_LOCUS12583</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5107095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1272at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.286.90">
        <property type="entry name" value="MFS transporter, transmembrane helix TM10b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029404">
        <property type="entry name" value="CDIN1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24064">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 22 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14811">
        <property type="entry name" value="TPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="46"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="80"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="202"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="228"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="257"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="392"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="422"/>
            <end position="445"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="452"/>
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    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="535"/>
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    <feature type="transmembrane region" description="Helical" evidence="5">
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            <begin position="654"/>
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    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
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            <begin position="1293"/>
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    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
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    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
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            <begin position="2930"/>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAG5107095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="3884" mass="438435" checksum="DBC77F51510EDA7D" modified="2022-05-25" version="1">MLFSLKLFPSSVRNSALGTCLVMSQIGSMSSPYLVDFLGQVAPWSPTVLCGGALFIAGLLCCIVPCLLQAIDELGRGSKFLWIAFFVSAISSLLKSLHTMSYVFIAEIPEHWCHFPELLDANWTAAQVQNISAVDKCLKYDYNYAYLAHLGYENAGKYVEDFKFNTSLVPCSSFIFDKSEKSTIVNEWSLVCDRQLYRANTYFTYSLGKLLGTGILGVYADKNGRRKALIISLTLQTIAVPLTSIIPWFWGYILCELLIGLSVAAMYSSAYTMVSEIANKNKMKILGTVSDALNPAETYKWHYHYSLFQQLSWFEESPRWLIALNRHNEAQKIIEKYRKITFTPNLITTSIPLTSISIDNSITEEKHQKSFAERYLGNSRILFTDPIYRKKILIMYFSFFVCVMVGYYLIFNVDNFKINRYIFMAAASTTELVSLLTVSIILRCISSQKTTIILYWIASICMLSMIAIPKDNIYMTIGMTVISKFCLSSTFTTNMLFSLKLFPSSVRNSALGSCILMAQVGSMSSPYLVDFLGKVAPWSPSVLCGGALFIAGLLCCIVPVPEHWCSIPEFEKFNWTAKQIKNISEVDECHIYNFNYTDLAGLKYEDAVKYVKDMKFNTSVIPCSSFVFDKNGRSTIVDEWQLVCDKKIYRANTFLAYAFGKLLGDGILGIYSDKYGRKQAMIVSLILQAISVPASAFIPWYWAYFGFKFMTGMSIMSEVTKNNKKNLFGAIIDSMFSIGTLLLIGIAFLPESPRWLLSQSRHEEAQKIVDKYSKTSKTTALIPASPNLSSSPSENEDTKKKVFNIDTFDTNRYIYTAITATVDLIAIILVPIILLCLSCQKASAVINTIVAICMLSIVTVPREHVYIVMALTFVSKFCLMANFTVNMLLASELFPTSVRNSALGSSLLMAQLGSMSSPYIVDFLGNVAWFAPTTLCELFKEIVKDIAKFQGLTRDCADLLIKKYVDVSPNAIHSILSAEVMQKMKTCRNKLHGIRYNHYGNYEKARKDGERPGIIVRMAAKANLPPALLARVILERYFQISRGDISQLMKDTTRIQDVDLAYEIYLCVLYDDRNGLISDSVCLAIGNEYEAKLQYYLDQCNASYSTEDDLRVRGYDKTPDVKLEIPVAVDGFIINWIESKGRFGSPDIHKTHVKEQFLSYWNRFGPGLVIYWFGFVDDIVEANEKKFIIMDHFPENIVHMNPTIPEKIIQETYLLQALDKLGQGSRFLWIIFAINMFIAVLDGLNCMSYVFLTETPNYWCFIPELVNANWTTDQLKSVFPVDKCQKYDYDYKNLANLGYDKAIKSIENLELKPTTIQCTSFLFNDSERHTIVNEWELVCEKNLYRANTFLVYALGMSFGSGILGTYSDRYGRKNSLIVSIILQVVFGPLTAFVPWFWAYMICRFFTGMSICAMASSAYTLLSEVTQNNMRKNLSASIDSTFSVGTFLLIGMAFFLSEWRYLQLALSCFVVPIIILIWYVSIEVLILNRICIIIYIFTSFTPESPRWLISQNRHEEAQKIIEKYDKSFVMPLISIMETSTIKRNSVSSSFVKLEKQKNFFYCNTESLRILFTNSDLRKKILIVYILSYVSSAICYSLIFNSDNFKLDRFIYMSVIAATEMTAHFVALVLLIYLSCRKTLVLAYTIGFIFMAAIPAIPEESKDIMMGFALIAKFCLSIIYTSKLVLIAKLFPSSVKNTAIGTCVLFSEIGGLTAPYIVDILGSVAYWAPTTLCGVLSLFAGILCLLIPRTKPKDKSDFDGRDEMDVKKRCLLQAIDQLREGSTVLWILLIMNLSTTFLFGINSMSYVFITEVPKYWCSPPELLKANWTIDQIKNITAVDDCHTYKYNYSYLASKGYDKVSRYVKDVKFLPSVDSCSSFTFDESKRSTIVNEWSLVCDRKLYRANTFLVYSLGIVTGSGLLGTYADKYGRKNSLIISIIFQVIAGPTSALVPWFWAYMIFRFFTGFSVGAMYSSAFTILSEITKGNRRKFFAAGLDASFSFGTFFLIGMAYFLPNWRQLQLAMWIPESPRWLISQNRYDEAQKIIEKYSKSFVMTQTSAAENQTNDSTLSSSECSPKLEENKGFFKRNSESLRILFTQSDLRKKILFMHFSYYVTAVASLTLAFNVDNFKSNRYIYLSILSINEVIANLATSVVLMFISCRKTLIINYFIGSSLMMAIIAVPEDNKNIIFGLALTAKFCTSASFTTNLVLNSELFPTNVRNTAFGTCIVMGQLGSLTAPYVVDLLGDLIWYAPTTFCGLLSLTVGLLGLLTPLTKIDDENDCTVEEKLTKEKTLLKAVDDLGEGSAFLWTIFVFNILTMILFGLNTMSYIFITEVCMSDYFCIPEFFCSIPELTKKKWTIEQIKNVSITNECQKYDYNYTQFAELGYDEALQYIANSESNPHVISCPSFTFDESGRSTIINEWDLVCDRSLYRPLTFSIFSFGMTCGSGILGTYADKHGRKSSLIISIILQTIVCPASALVPWFWAFIIFKFLTGVSIGAINSLFNIVIKTIIFYLAVTEVARSKRIKVFAAILDATYSIGTYFVIGMAYALPNWRHLQLAVSSFILPMIILICICVKKLWIPESPKWLISQNRYDEAQKIIEKYSKSFVVTPTPAAANQTNDSTLSSSEYSPTLEENKGFFKRNSESLRILFIQSDLRKKILFMYFSYYVTSIISFSLAFNADNFKLDSYIYLLIISLVDAAAHLTTSIILMFLSCRKSLIIMYVIGFIVMIAILAVPLESKIIIAVLALVSKFCLSVSFTANLVLNSELFPTIVRNTAFGTCLVLSQLGSMSAPFVVDILGNVTWWLPTTFCSVLALFAAFLCIITPLTKIDEENESREKCLLQAVDELGQGSSLVWIVFIINLFTLQLFGLNSMAYVFIAEIPEFRCFIPELSDANWTTDQINEISIFDTCQHYDHNHTYLANLGYDRAVQFVEELEFLPNIISCSSFTFDNERSTIVDEWELVCEKKLYRATTFLLYALGITCGSGILGIYSDAYGRKKSLVISIVLQVIAGPASALAPWFWAYSLCRFITGMSTGGMYSSAFTILSEISKDKRRKVFAASIDSTFSIGIFFLIGIAHFLTNWRQIQLGISCFLIPIIALIWFIPESPRWLIAQNPQKIIEKYHKSFATTLSSSEENKKKESQLSSIANIPVLPKKEGSFFRRNFGSLGILLTTSDLRRKILVMYFSYYVTTVVSLSLVFSIDNFKADRYIYMSVVALNEIIAHMAILVVLMFVSPRKLLVIVYMIGAVLTISILAASEENKTMIMGLALAARFCTSASFTINLVLNTELFSSNVRNTALGTCVVTGQLGSLTAPYIVDILGSIAFWAPTTLCSVLFLLASLFGFILPRSKIEEEENPLGVKEDNKGKNKIQEECLLQAIDDMGGRSSKLLWIIFIVNFFTLQLYGNNSMSYVFISEVPEFHCSIPELKNANWTTDQINEIAIVDSCTQYKLNYTHLANLGYDNALEFVKESEFLPSVVSCTSFTFNESVHSTIVDEWELVCEKKLYRANTFLVYSLGVMVGSGILGIIADKYGRKNSLIISIVLQVIASPTSALVPWFWMFIICKFFIGMSTGAISCDGQHKKSVCRYSRCVFFDWNVFCYRNGILFKNLATIATSNFLWLISQNRFDEAQKIIEKYHKSFVMTPNNSLEDSKTDDKFSLSKLPNINQENEGFFHRNVESLRILFTQPDLRKKMLIMYFSYYVTAATSYALVFSIDNFKSDRYVYVAILAFNDIIAHLSILAILIYLSGQKALIMTHSTASLLMITILAISEDNKNIIMGLALAAKFCAATSFTANLVLLSELFPTNVKNTALGTCVVMGQVGSMTSPYIVDVLGSIAWWAPTTLCSTLSIMAGLLCLTIPRTRINDEMMINDIFDFHWYVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MSI6</accession>
    <name>A0A8J2MSI6_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS12674</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5107288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MSI6"/>
    <dbReference type="OrthoDB" id="3800936at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="8"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5107288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="109" mass="10411" checksum="A8A68CC13786B9D5" modified="2022-05-25" version="1">MDAGRGRGQVARGRVVGGPQARGQVRGGRNPATSGARGAQRPAVRGGVRAKGSLPGEDGLVNGGGGGGGGGGGGSGGSGGVGFTDRSGATGAATGDDHEWYQDSYNSWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MTH9</accession>
    <name>A0A8J2MTH9_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS13523</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5108887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MTH9"/>
    <dbReference type="OrthoDB" id="7700366at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5108887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="119" mass="12314" checksum="C0F9071BB7690219" modified="2022-05-25" version="1">MEKLSVCFIKKKAYSHALIGSLSRALGLRPRSEKVSPSSSSDTGSLASQCQYMSSIRSNSPPPPQLPPRPNANGGIGSVGGIGLGIGIGIGSGNGKRHRRVKSIGDIEYITNAPVSTPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MU74</accession>
    <name>A0A8J2MU74_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similar to Lin52: Protein lin-52 homolog (Mus musculus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS7971</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the lin-52 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5095964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MU74"/>
    <dbReference type="OrthoDB" id="5834362at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070176">
        <property type="term" value="C:DRM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018737">
        <property type="entry name" value="DREAM_LIN52"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031568">
        <property type="entry name" value="Pet117"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31489">
        <property type="entry name" value="LIN52 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31489:SF2">
        <property type="entry name" value="PROTEIN LIN-52 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10044">
        <property type="entry name" value="LIN52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15786">
        <property type="entry name" value="PET117"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5095964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="177" mass="20268" checksum="8849674222DA6C9C" modified="2022-05-25" version="1">MSFTSRLVLFGSCTLTVGIIGYVHYKQHDDREQLHLGVVRDIERQERRKAENVYLLEQQRELTKKLKHVTCLDDSLMSLEKLDRASPELWPEQTIDQVPGVNEFIAQNLSPSEQSSWSASGISTDDMAQLHQLGNLPVTSLIAEVKKLHDLAYQLGLEEAKEMTRGKYLNIFKNKEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MV45</accession>
    <name>A0A8J2MV45_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 20">Polypeptide N-acetylgalactosaminyltransferase</fullName>
            <ecNumber evidence="20">2.4.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="20">Protein-UDP acetylgalactosaminyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">HICCMSTLAB_LOCUS8578</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>L-seryl-[protein] + UDP-N-acetyl-alpha-D-galactosamine = a 3-O-[N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23956"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:12788"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:53604"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:67138"/>
            <dbReference type="EC" id="2.4.1.41"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>L-threonyl-[protein] + UDP-N-acetyl-alpha-D-galactosamine = a 3-O-[N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:52424"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11689"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:67138"/>
            <dbReference type="ChEBI" id="CHEBI:87075"/>
            <dbReference type="EC" id="2.4.1.41"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 20">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 20">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 20">Golgi apparatus membrane</location>
            <topology evidence="2 20">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 20">Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="20"/>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5097173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MV45"/>
    <dbReference type="OrthoDB" id="6159198at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004653">
        <property type="term" value="F:polypeptide N-acetylgalactosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006493">
        <property type="term" value="P:protein O-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23439">
        <property type="entry name" value="beta-trefoil_Ricin_GALNT10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02510">
        <property type="entry name" value="pp-GalNAc-T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.80.10.50:FF:000011">
        <property type="entry name" value="Polypeptide N-acetylgalactosaminyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000029">
        <property type="entry name" value="Polypeptide N-acetylgalactosaminyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045885">
        <property type="entry name" value="GalNAc-T"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000772">
        <property type="entry name" value="Ricin_B_lectin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11675">
        <property type="entry name" value="N-ACETYLGALACTOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11675:SF134">
        <property type="entry name" value="N-ACETYLGALACTOSAMINYLTRANSFERASE 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00652">
        <property type="entry name" value="Ricin_B_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00458">
        <property type="entry name" value="RICIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="Ricin B-like lectins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50231">
        <property type="entry name" value="RICIN_B_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15 20" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="16" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 20" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="13 20" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10 20" id="KW-0430">Lectin</keyword>
    <keyword evidence="17 20" id="KW-0464">Manganese</keyword>
    <keyword evidence="14 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="7 20" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 20" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="domain" description="Ricin B lectin" evidence="21">
        <location>
            <begin position="452"/>
            <end position="580"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00050905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00052209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="RuleBase" id="RU361242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="SMART" id="SM00458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="CAG5097173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="597" mass="68101" checksum="7A9877423E5470D3" modified="2022-05-25" version="1">MKRNVISLIKFLFVATFAVLLTIVVFRYVRGPRLSIAGSPHSLNIFEGDKNYPNGQLEEKIDWHDYKKMKEDSSRVGIGEQGKPATLSPSKRLTEDKLYKVNGFNAALSDEISLNRSVPDIRHPDCKKKTYLKNLNSVSVIVSFHNEHFTTLLRTCWSVINRSPPKLLEEIILVDDASTKVELKDKLDRYLASNLPKVSVIRLTQRSGLIRGRLAGAKKAKAKILVFLDSHTEANVNWLPPLIEPITKDYKTCVCPFIDVIAFDTFEYRAQDEGARGAFDWELYYKRLPLLPADLANPSEPFKNPVMAGGLFAISAKFFWELGGYDPGLDIWGGEQYELSFKIWQCGGQMFDAPCSRVAHIYRKFAPFPNPGKGDFLGRNYKRVAQVWMDEFAEYIYKRRPHLRSLDPGDLTVQKALREKLNCKPFKWFMENIAFDLMDTYPPVEPEDFALGEIRNIGVSELCLDAKRRAKNEAIAVDLCVKDNVKVANGEQEFRLTWRKDIRPKTRTDCLDVSSGVAKAPVTLYPCHGQQGNQRWRYDVEKQWLLHGLGDRCLDTDPATKKVFVSACDPASSTQKWRIHEVNMKAINNWENVGPKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MVL6</accession>
    <name>A0A8J2MVL6_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HAT C-terminal dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS9015</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5098065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MVL6"/>
    <dbReference type="OrthoDB" id="10023262at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37162:SF1">
        <property type="entry name" value="BED-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37162">
        <property type="entry name" value="HAT FAMILY DIMERISATION DOMAINCONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5098065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="509" mass="58443" checksum="E101F42CC66DD5DB" modified="2022-05-25" version="1">MVTTKLRAHKNDFIRHKDSEKHKKNSAAITFHPSINQVFPTVDPVNKKKLGTKFELQLAVHVACHSSIRHNLNLQQCFAIATDGGSNLCGCNKSLYTLMKKKRDDLMLFKCICHSIHLVCSHASEELPSALRRKKYLDIYNTINDGTDPLQMVHLSTTRWLARGQAIERILDQWDTLKLNFDFAATEPHQDRYVAKELQQMYNDPANLLYFTFLSPLLSEFNSINLLFQKEHADHFSILQELERFTLSLLRRVLHPSSVSLEVDLNFQSIYLPLQKVDFGYKFTALVNRLVKDTDISQTTVNNVKHRCQLFLIRACKELLSHTSGNTAILKKIRVFSPKICLKSDRPAFAELPLNLLKKGVDINAAESQWRKLLDFDFESIFDESIMAQGPMFWSKVIKLTDSEGNYIFKDIASLALTAYSLPVSNASVERVFSRVTLTKTKLRNRMTLLLLSAILRIKMHLEENGICCTKFEPTGDMLNFNSTIYDKKKTDTSEEDENVEELLKNLNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MVX5</accession>
    <name>A0A8J2MVX5_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Splicing factor 3B subunit 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HICCMSTLAB_LOCUS10268</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RSE1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5101195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MVX5"/>
    <dbReference type="OrthoDB" id="436637at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.910:FF:000002">
        <property type="entry name" value="Splicing factor 3B subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000027">
        <property type="entry name" value="Splicing factor 3B subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000041">
        <property type="entry name" value="Splicing factor 3b subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018846">
        <property type="entry name" value="Beta-prop_RSE1/DDB1/CPSF1_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058543">
        <property type="entry name" value="Beta-prop_RSE1/DDB1/CPSF1_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050358">
        <property type="entry name" value="RSE1/DDB1/CFT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004871">
        <property type="entry name" value="RSE1/DDB1/CPSF1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10644">
        <property type="entry name" value="DNA REPAIR/RNA PROCESSING CPSF FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10433">
        <property type="entry name" value="Beta-prop_RSE1_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23726">
        <property type="entry name" value="Beta-prop_RSE1_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03178">
        <property type="entry name" value="CPSF_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RSE1/DDB1/CPSF1 first beta-propeller" evidence="6">
        <location>
            <begin position="14"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="domain" description="RSE1/DDB1/CPSF1 second beta-propeller" evidence="7">
        <location>
            <begin position="505"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="domain" description="RSE1/DDB1/CPSF1 C-terminal" evidence="5">
        <location>
            <begin position="822"/>
            <end position="1133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00040929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF10433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF23726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG5101195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="1167" mass="129409" checksum="A6BB4378DB86C384" modified="2022-05-25" version="1">MYLYNLTLQRATGITHAVHGNFSGTKLQEILVSRGKSLELLRPDPNTGKVHTLLAVEVFGIIRSLMAFRLTGGTKDYIVVGSDSGRIVILEYLPAKNVFEKVHQETFGKSGCRRIVPAAIEKQKLVYILNRDPEARLTISSPLEAHKSNTLVYHTVGVDVGFENPMFACLEIDYEEADSDPTGEAAVKTQQTLTLYELDLGLNHVVRKYSEPLEEHANFLISVPGGNDGPSGVLICSENYLTYKNLGDQPDIRCPIPRRRNDLDDPERGMIFVCSATHKTKNMFFFLAQTEQGDIFKITLEVDEDMVTEIKLKYFDTVPVATSMCVLKTGFLFVASEFGNHYLYQIAHLGDDDDEPEFSSAMPLEEGDTFFFAPRPLRNLVLVDEMDSLSPIMTCQVADLANEDTPQLYIACGRGPRSTLRVLRHGLEVSEMAVSELPGNPNAVWTVKRRIDEEYDAYIIVSFVNATLVLSIGETVEEVTDSGFLGTTPTLSCSALGEDALVQVINQRQVVIALTGGELVYFEMDPTGQLNEYTERKKMPSEVMCMALGNVAAGEQRSWFLAVGLQDNTVRIISLDPSDCLAPRSMQALPAAAESLCIVEMGASKDVDNSDDTVIQNQTSLYLNIGLQNGVLLRTVLDPISGDLADTRTRYLGSRPVKLFRIKMQGSQAVLAMSSRSWLSYYYQNRFHLTPLSYESLEFASGFSSEQCPEGIVAISTNTLRILALEKLGAVFNQVSFPLEYTPRKFVIHPDSANLIIIETEHNAYTEDTKQQRRLQMAEEMQEAAGAEEATVARELAEAFLSEEPNEAVFGAPRAGPGLWASLIKIMVPTTGQVFQTHRLEQDYAALCLALVKFANQGDQLFLIVGVAKDYQLNPRISSVNADGTGIELLHKSPVDEIPLAICPYQGRVLVGVGKMLRLYDMGKKKLLRKCENKHIPNAIVSINAVGQRIYVSDVQESVYAVRYKRQENQLIVFADDTHPRWITTTCVLDYDTVATADKFGNIAVVRLASGINDDVDEDPTGNKALWDRGLLNGASQKADTVASFHVGETVMSLQKATLIPGGSESLVYTTLSGTVGVLVPFTSHEDHDFFQHLEMHMRSEHPPLCGRDHLSFRSYYYPVKNVIDGDLCEQFNSIEPAKQKGIAGDLERTASEVSKKLEDIRTRYAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MXN7</accession>
    <name>A0A8J2MXN7_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">CCR4-NOT transcription complex subunit 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">CCR4-associated factor 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">HICCMSTLAB_LOCUS11765</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the CNOT1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5103949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1933107at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030015">
        <property type="term" value="C:CCR4-NOT core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060090">
        <property type="term" value="F:molecular adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017148">
        <property type="term" value="P:negative regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000288">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031047">
        <property type="term" value="P:regulatory ncRNA-mediated gene silencing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd20710">
        <property type="entry name" value="NOT1_connector"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.800:FF:000001">
        <property type="entry name" value="CCR4-NOT transcription complex subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.180:FF:000005">
        <property type="entry name" value="Ccr4-not transcription complex subunit 1 isoform"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.790:FF:000001">
        <property type="entry name" value="Ccr4-not transcription complex subunit 1 isoform"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.840:FF:000001">
        <property type="entry name" value="Ccr4-not transcription complex subunit 1 isoform"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.800">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.840">
        <property type="entry name" value="CCR4-NOT transcription complex subunit 1 TTP binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007196">
        <property type="entry name" value="CCR4-Not_Not1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055454">
        <property type="entry name" value="CNOT1-like_NOT1_connector"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055104">
        <property type="entry name" value="CNOT1_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032191">
        <property type="entry name" value="CNOT1_CAF1_bind"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024557">
        <property type="entry name" value="CNOT1_dom_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032194">
        <property type="entry name" value="CNOT1_HEAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032193">
        <property type="entry name" value="CNOT1_TTP_bind"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038535">
        <property type="entry name" value="CNOT1_TTP_bind_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040398">
        <property type="entry name" value="Not1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13162">
        <property type="entry name" value="CCR4-NOT TRANSCRIPTION COMPLEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13162:SF8">
        <property type="entry name" value="CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22940">
        <property type="entry name" value="CNOT1_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16415">
        <property type="entry name" value="CNOT1_CAF1_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16418">
        <property type="entry name" value="CNOT1_HEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16417">
        <property type="entry name" value="CNOT1_TTP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12842">
        <property type="entry name" value="DUF3819"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04054">
        <property type="entry name" value="Not1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23590">
        <property type="entry name" value="NOT1_connector"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0678">Repressor</keyword>
    <keyword evidence="7" id="KW-0943">RNA-mediated gene silencing</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0810">Translation regulation</keyword>
    <feature type="domain" description="CCR4-NOT transcription complex subunit 1 N-terminal" evidence="19">
        <location>
            <begin position="27"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="CCR4-NOT transcription complex subunit 1 HEAT repeat" evidence="18">
        <location>
            <begin position="495"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="domain" description="CCR4-NOT transcription complex subunit 1 TTP binding" evidence="17">
        <location>
            <begin position="803"/>
            <end position="987"/>
        </location>
    </feature>
    <feature type="domain" description="CCR4-NOT transcription complex subunit 1 CAF1-binding" evidence="16">
        <location>
            <begin position="1059"/>
            <end position="1280"/>
        </location>
    </feature>
    <feature type="domain" description="CCR4-NOT transcription complex subunit 1" evidence="15">
        <location>
            <begin position="1455"/>
            <end position="1602"/>
        </location>
    </feature>
    <feature type="domain" description="CCR4-NOT transcription complex subunit 1-like NOT1 connector" evidence="20">
        <location>
            <begin position="1703"/>
            <end position="1900"/>
        </location>
    </feature>
    <feature type="domain" description="CCR4-Not complex component Not1 C-terminal" evidence="14">
        <location>
            <begin position="2099"/>
            <end position="2454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1014"/>
            <end position="1035"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1288"/>
            <end position="1309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1384"/>
            <end position="1427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="1300"/>
            <end position="1309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1405"/>
            <end position="1416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00025717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00032531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00071432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF04054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF12842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF16415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF16417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF16418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF22940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF23590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="CAG5103949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="2476" mass="279137" checksum="14B5CA07B442BCBA" modified="2022-05-25" version="1">MNLDSLSFTLTQINYLIVNLNKKNYRDSTEEISVLVRWKGLEADRHLLRCLFSHIDFSTGETPNTSSKDYYQVQLLKQECTNILGKPSLVSNLCYAIDHPLHHQKTLKPSLKFFLHLRRVLSLTLVQEIVFAIALQHSENAELRSLALEEVKKQLPDLINNYIQSADSTGNKQQEDGLHDSSPEVLHLILIETLKDQNSYGLSLETKEKFLKNLKRDFPRELVPVVLAPLLYPGDGEITHDANSLVELIMELGYGFTNNVEDCRAALTGLGAREISPLAAARVLAHMARTYSGLDDAGGLQSFWSISSNNADGNKDKSDGNPSSTWNVEVFVQTLKEIQSTLSWNEVIVKLDHPDFHIKNRQSLNLLITGLRLGLQLQGFPLDVFPVELFYRHWDNVEGQFSLIQQILKNPDVFCFADYPYHSVTVDVLKAAPEGDSKESQTWRSLNVVELLLHMAERGLNGPVQDIFKWPIQHCPDVLVLALLQINPPITMLRQELLSTLMPIFLGNHPNSAVILHHAWHANNLKIKSIIMHAMADWYLRGDNDQTRLSRILDVAQDLKALSALLKAQSFPFVIDLACLASRREYLKLEKWLGDKIRDHGEIFIAACVKFLQRRCPQVMGPGIKEDTTIPKASQLPQETLTTILMVLQPCTASLSQELADTIITMIGNCSMMLKTNLNRPPPPGVMRHPALDVFNPVKLAAPLFPTKPIDTLGNLSTNLASMGIGSGLGPPSTSAFNLPGALGPLVSAPGSPSRLMGPSPNPFPMMPMSSQIHSGPVGTQSTAVIPGAASIGGNGRLGPPANIEKTRIPEISNLFPDMPQIVSKDIEDEANSYFMGIYNHSPHQTLSIDEVLDILKKFQNSTIKREHDVFQCILRNLLEEYRFFPQYPEKELHITAQLFGGIIDRGLVNNYMTLGIALRFVLDALRKPEGTKMYFFGLAALDRFKSRLKEYSTYCEHVRAIHHFLEFPSHLVEYIEFGLSGQEPPHKPQGPIYPKSHPLMMNQATTAYKSITTTTATSNTQSKPSTTPTTSMSARPSIANATNIDTLLVATDKEEMKITVPPETMQDKTAFIFNNLSQINLQAKCDEIREIVTEEFWPWIAQYLVMKRASIELNFHVLYSNFLDYLKVPEVNRLVTRETFRNIKVLLRSDKGIANFSDRSLLKNLGHWLGMLTLGRNKPILQVDIDLKSLLVEAYNKGQQELLYVVPFVAKVLESCAKSRVFRPPNPWTMSIMNVLAELHQEPDLKLNLKFEIEVLCKNLSIDVSELKPVIYLKDPEKIRSIEYQLSQPNKKSEASHSAQQQQQQQQHQQQQQQAQQQAQQQAQQQAQQQAQQQAQQQQQQQQQQQQQQQQAQQQQQQQQQQQQQQQQLAQQQSQQQQQQQQQQSSQQNTMEELVGSSAPGVISQPQPANTTPSLPTGPPEPRFNYMDINVSNVANVAQHITVNNQLPLLQASPHLKQFIRPSIERAIQEWIHPVVDRSIKIALTTSEQIARKDFALDPDETRMRQAARHMVRNLVAGMAMITCRDQILASISTNLKQAFLAALMGSTQQQKDLVEQAANVLAGDNMELACAFVQKTAIEKAMPEMDKRLLNEIELRKIARQEGRRYFDPVAKYQAERMPEQIRLKAGGVTPQQMAVYEEFARNIPGFLPLSERETQALFIPKPISEPTAVTAFASNPAVTLPTQQVAVYANAAVNNDEVGTMLEKLGSEVELLLTSTAAPPQQLTGLHALLESIILTRRSRDAGAAMALLKRAVDGLLESPSASSSTIESELILRYRELHLRILKCLQDPRAYGLQWTNKNVARVWADGREECRFNFEAVDCLIRSHLISLPQLDGALAQAMEGGIAMAVAFAMQLVQVYLIDERQTTHVNESDLYNVLESLARMAHHRATPDGISVFRLTSVMESLRANHESGVLADRSSVGPTAHIHSGISQVRARDFDDPPGLMEKTEYLLREWVTMHHSPNNSRDPTKAFGLFVHQMNIHGILKTDDLITRFFKLSTQMCVDLCYRALAESNLAVSAVRAKCFLTLDAFVKLVALLVKHSGDTSNTHTKINLLNKVLGIVAGVLLQDHEMRSTDFQQLPYHRIFIMLFLELCAPEPVLEAVNYQVLTAFCHTLHILRPAKASGFCYAWLELVSHRVFIGRMLAITPQQKCWGMYAQLLIDLFRYLAPYLRNAELAKPVLFLYKGTLRVLLVLLHDFPEFLCDYHYGFCDAIPPNCIQMRNLILSAFPRNMRLPDPFTPNLKVDMLQEIAHAPRVLTNFASIIQPLSFKKELDSYLKARAPVTFLSELRSNLQVSQEAGMRYNIPLMNALVLYVGTQAIAFIRNKGHTPNMSTIAHSAHMDIFQNLAVDLDTEGRYLFLNAIANQLRYPNSHTHYFSCTLLYLFAEANTEAIQEQITRVLLERLIVNRPHPWGLLITFIELIKNPTYKFWTHEFVHCAPEIEKLFESVARSCMVQKQVLSTQSTQEPELPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MXQ3</accession>
    <name>A0A8J2MXQ3_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">phosphatidylinositol N-acetylglucosaminyltransferase</fullName>
            <ecNumber evidence="2">2.4.1.198</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">GlcNAc-PI synthesis protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HICCMSTLAB_LOCUS11827</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="pathway">
        <text evidence="1">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.198" evidence="2"/>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5104088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MXQ3"/>
    <dbReference type="OrthoDB" id="734129at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000506">
        <property type="term" value="C:glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017176">
        <property type="term" value="F:phosphatidylinositol N-acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd03796">
        <property type="entry name" value="GT4_PIG-A-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000026">
        <property type="entry name" value="Phosphatidylinositol N-acetylglucosaminyltransferase subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000148">
        <property type="entry name" value="Phosphatidylinositol N-acetylglucosaminyltransferase subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039507">
        <property type="entry name" value="PIG-A/GPI3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013234">
        <property type="entry name" value="PIGA_GPI_anchor_biosynthesis"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45871">
        <property type="entry name" value="N-ACETYLGLUCOSAMINYL-PHOSPHATIDYLINOSITOL BIOSYNTHETIC PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45871:SF1">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL N-ACETYLGLUCOSAMINYLTRANSFERASE SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13692">
        <property type="entry name" value="Glyco_trans_1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08288">
        <property type="entry name" value="PIGA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 9" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="387"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="domain" description="PIGA GPI anchor biosynthesis" evidence="8">
        <location>
            <begin position="45"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00032160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAG5104088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="442" mass="49917" checksum="06E0C1692A6B0ED4" modified="2022-05-25" version="1">MNQVKHKICMVSDFFYPNMGGVEEHIFNLSQCLLGRGHKVVVMTHSYGDRVGIRYMTNGLKVYYLPIKVFYNQCVLPTMICSLPLIRYIFIREQIEIIHGHSAFSALAHEGMLIGRLLGLKTVFTDHSLFGFADTSAVLTNKCLQISLADCNHCICVSHTGKENTVLRAKVHKDRVSVIPNAVDTALFTPDISKRKSNCITIVVVSRLVYRKGVDLLAQIIPRICSRHQDVQFLIGGDGPKRWLVEEIRERNLLQHRVTLLGSLEHSQVRHVLNKGHIFLNTSLTEAYCMAIVEAASCGLQVVSTKVGGIPEVLPPELIYLVEPKVDALVEALEQAIADYRTGNIICPYQVHDKIVSIYNWFNITKRTEIIYDSVQQESKKTIGEQLANYLSSGVLPYLLMVSLCYIALQILEYIVPRKYIDIATDYNQPEPSLKNKKNRTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MXR1</accession>
    <name>A0A8J2MXR1_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS11857</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5104148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MXR1"/>
    <dbReference type="OrthoDB" id="7681265at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="400"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="560"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="400"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5104148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="813" mass="90954" checksum="9A1D4A55C319509A" modified="2022-05-25" version="1">MEARRNIERGNHLSRHKYEDSFLSDEELSQNLKDTRFFTSSSDLESSKQERDNYYALKYPSLARLEETCREIEAENKAKADLLDPKTDISSHKSETSYYSSQSTYQANSSAIQTTEESFTSRSFEVINNLLNKNINDTVTTASSYADAVGCPNNPHDSWLHLDSSTANTSLLEIKEVLHQLGNVRVRNLDSTSSNNGRQSYLDRLTKSFEKLPSDFKEQLKTILEETQLTSHDESISAFRDLVLQVIGKTRDLQDETIPFTSDQTIFKDTPEVFPSVEPSDEGNLSKTPMNNTRNKKVYRKTPIDLMKSSAYASTPLRIAALTRGMETPNSDTKSPIFLGSGRDFNESSFTFHERQCLGDDIPKSPKPMPELTEEQKKLLEECRQKELALASVSPFSVKDSKNESREFEENGSPFLTPDSLKAPGRASSNLYDSLDDWDIEKEMAERDKRLAETEMTIKNIVEDKIAGSYSTEFLNVVNNYFDVSNSSRLKSGDGLYDSGVETAIGSRRTDKLSSSDESLDSRMGNVTLRKLSSSSVKKFTRSKSCKSPEMNSRCKATGLMRNKSPSSKRVAVTPKSTPRVLQRTTSAPVTPRVVSARKNISTKFTPSKMSSALSAVASKSVSKVTSKVFKVPANPPMIMVTPNTPTSSSKNFSTFKSPRLEYGGKYFCTPGKAPPKEKRVFFPTPGKKNIPKSNKGDLLDKIYPGSSEVRSPVADYIRGGRDAITIKTIPKLQNEYLLSKEEVLNYKPKKINNENNPPNFEFNFPSAVYQSKKQVQEFDASPVTPQGSRVKKLVAKKDSRAVIKHQIDAVLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MZ36</accession>
    <name>A0A8J2MZ36_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase</fullName>
            <ecNumber evidence="4">1.1.1.179</ecNumber>
            <ecNumber evidence="3">1.3.1.20</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">D-xylose 1-dehydrogenase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">D-xylose-NADP dehydrogenase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Dimeric dihydrodiol dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HICCMSTLAB_LOCUS12314</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>(1R,2R)-1,2-dihydrobenzene-1,2-diol + NADP(+) = catechol + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16729"/>
            <dbReference type="ChEBI" id="CHEBI:10702"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18135"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.3.1.20"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>D-xylose + NADP(+) = D-xylono-1,5-lactone + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22000"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15867"/>
            <dbReference type="ChEBI" id="CHEBI:53455"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.179"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the Gfo/Idh/MocA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.179" evidence="4"/>
    <dbReference type="EC" id="1.3.1.20" evidence="3"/>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5106547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MZ36"/>
    <dbReference type="OrthoDB" id="2129491at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047837">
        <property type="term" value="F:D-xylose 1-dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004420">
        <property type="term" value="F:hydroxymethylglutaryl-CoA reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047115">
        <property type="term" value="F:trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3270.10">
        <property type="entry name" value="HMGR, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050984">
        <property type="entry name" value="Gfo/Idh/MocA_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055170">
        <property type="entry name" value="GFO_IDH_MocA-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023282">
        <property type="entry name" value="HMG_CoA_Rdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22604">
        <property type="entry name" value="OXIDOREDUCTASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22604:SF105">
        <property type="entry name" value="TRANS-1,2-DIHYDROBENZENE-1,2-DIOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22725">
        <property type="entry name" value="GFO_IDH_MocA_C3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gfo/Idh/MocA-like oxidoreductase N-terminal" evidence="11">
        <location>
            <begin position="4"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="GFO/IDH/MocA-like oxidoreductase" evidence="12">
        <location>
            <begin position="118"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00040603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00042926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00042988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00043025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF22725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAG5106547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="318" mass="35019" checksum="A56B051BF1A2DBB3" modified="2022-05-25" version="1">MATRWGIASAGKISHDFTNAVATLPNNEHEVVAVAARDIKRAEEFAKLHRIKKAYGSYEELAKDTDVVAKLMLNHGKHVLCEKPLTMNLKQTTELINFAKSKGLFLMEAIWSRCFPVYEAVKKAIKAGEIGDVKQVIVSFGFAMEHVDRLNVKEMGGGTILDLGVYTLQLAQFVYDGEKPIDVKAGGFLNADGVDKSMSATLIYKNDRTATIMTHSVVTLPNEAVIIGTKGVIKIPTFWCPVTAELPSGKIKFDLPKAPHEFNFVNSAGLRYEAAEVRACLQAGLKESPKVSHAESLMIAELEDELRRQIGVVYPQDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2025-06-18" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2N0I2</accession>
    <name>A0A8J2N0I2_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Similar to chif: Protein chiffon (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HICCMSTLAB_LOCUS13631</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5108995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="21380at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031431">
        <property type="term" value="C:Dbf4-dependent protein kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043539">
        <property type="term" value="F:protein serine/threonine kinase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010571">
        <property type="term" value="P:positive regulation of nuclear cell cycle DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901987">
        <property type="term" value="P:regulation of cell cycle phase transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="6.10.250.3410:FF:000001">
        <property type="entry name" value="Protein DBF4 homolog A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.3410">
        <property type="entry name" value="DBF zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051590">
        <property type="entry name" value="Replication_Regulatory_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006572">
        <property type="entry name" value="Znf_DBF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038545">
        <property type="entry name" value="Znf_DBF_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15375">
        <property type="entry name" value="ACTIVATOR OF S-PHASE KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15375:SF26">
        <property type="entry name" value="PROTEIN CHIFFON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07535">
        <property type="entry name" value="zf-DBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00586">
        <property type="entry name" value="ZnF_DBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51265">
        <property type="entry name" value="ZF_DBF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DBF4-type" evidence="6">
        <location>
            <begin position="301"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="100"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="469"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="643"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="714"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="776"/>
            <end position="868"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1013"/>
            <end position="1037"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1050"/>
            <end position="1093"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1192"/>
            <end position="1523"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1580"/>
            <end position="1603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="469"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="506"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="714"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="728"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="791"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="807"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1054"/>
            <end position="1070"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="1244"/>
            <end position="1269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1291"/>
            <end position="1303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1310"/>
            <end position="1321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1338"/>
            <end position="1367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="1369"/>
            <end position="1380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1397"/>
            <end position="1408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1456"/>
            <end position="1474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="1479"/>
            <end position="1498"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAG5108995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="1614" mass="182481" checksum="130C4BF94066B165" modified="2022-05-25" version="1">MVSPSKNHNQKQKSLAQDNKITRPSHVRLQRGDKPLGKNKFYLDIKNHSLSSRLEARIKDLGGRVELFLDARVTVVVSDRADKFQQQSAVVAATASSDKKKCGYTSGGSAGPPSLKSVEVPSSTWTPPTPSYNGECPLSNSTNTRGLTTQRIKSRVDAMLERALTQPQQCSVDPLDTAFNWGIPIWTTDRLQGYLDKVYATLSNINTLKNLNRIKSEKDLKVKELKKPYIKFESSKRDTRPVFLELPVWPTLNFDGEPGTCPFDKPRKIKEEEKKNNIINKKKEMTRKPRANTATRARRSEQLVGGFCEICRCDYKDLTKHVQSDKHLTFVRNDDNFLSLDSLINAGANVEAFLKLNQSDDVEKNLYTNGNDNLHNVIRNEGVNQTDKSDLADYGVDGLKMVQCNGARRKLNLNLSSPHNLRARAKHESGHLLRSKGSPWHEVDKSEKLFDKLERYTIKKRSKGTIWIEEDDSPDKCDDDSEDPLKDEKLTTAATVVEKSPLSELNDVRVKNKDSRDQSSKKNQQLSSSRGDDRRNKKGILCPDRSISENNAKDNNNSNDVLLNQKKECPVRIITNNDSNKKSPGKDFCANGSSVKPIVLAQKPDNLVQTLDTRCSADNNKTNQSTTVDNNINIDANDKSVKSTKICPSEDNDDSKEETNKTKCNRVNNSARRIAVRSSRGRRRQSVEERLIKDNRAFYKVEVIGNKLRSNTAHLNSNINDQSTPVVKEVEKEKEKEKEKEKEKEIKKDEGPSSEKPVVVRFKRVRKSELSLLSDEAESFMFGDSKRDSSDWNNDSRGNSSSSVLPKDTESSEGDNKPSSSSIISSSPVTTVELPDNSPVKEEPPADDDSQDSSNVGRAKKRRRTQAEALIKDNSEYYKFETPVCRLRFQNGPTCIIKPVDNPPEENKCEQVTLKNEQTTIIVSEVNAEGLQVTIPTEEKLYPSKPSAEIEKMRFSFESIPKSEPWYQTYQRQDLGAEFWHSFSEPDSNKPFLLPYEIENFHENLLKLCQKTESRKRARNQGPHGLGRSPRKSPRCHASTLAIMSTIIRKREQQQQIQQEKQQQQLQPQPTNLSGSEDARVDVNNVKSDPKSSTDFELKEIVKSIDDMLNADIPFDDSFEPDLGTISEGEEDMNENQDLQQILSHQSIIPSEASGPPPNLLELLNNCPQQVNVFDNSSCASSECGEVVVESPLKRRKRRKNRTGWPGIKARKKLQCKQQPTPDVDSERENVPAKSTHTRNPNENENENENEDEEEEEEEDEDEDEEEEGTESRLNQQKIIERLQAPGTESADLSSHDSNISQPTKDKNLTELNESLLSQPSELDNNNKNPDEDNSNELVRKCNKEKNDEGNDENNHENVLKEQDSRASTKNKSKATRKRPQREVLDGRPSSSMTIESHPEIENHDNLCRQKTSSSVILRKNYSGGTTLSKRRQRENASESSGADGTAGGQVTEVTRQNDDSSHREAASCKKKDSTSSPSKKKQALVRARSKKRSRRNRSTSEMSFDDENCKKVNDDDSDDEMDCPLSERVIPQQQIVVTAPELQQRRSSIEFQPVVRVMKIEDQVDMDHNILSVTVASNRRLRSSGSPKHRNSSPPAKRYKRSKGFISRWIKNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2E7C9</accession>
    <name>A0A8J2E7C9_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Gustatory receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HICCMSTLAB_LOCUS1895</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Cell membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the insect chemoreceptor superfamily. Gustatory receptor (GR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001116">
        <property type="protein sequence ID" value="CAG5075854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2E7C9"/>
    <dbReference type="OrthoDB" id="6366728at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050909">
        <property type="term" value="P:sensory perception of taste"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013604">
        <property type="entry name" value="7TM_chemorcpt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08395">
        <property type="entry name" value="7tm_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 7" id="KW-0675">Receptor</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="41"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="79"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="134"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="168"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="247"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="283"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAG5075854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="330" mass="37843" checksum="F283D73D9E96E57B" modified="2022-05-25" version="1">MFESIYLIFFGIVGLTSIKIKQPRSSNTPKLIKYSQSRIGYFYLIFLIILTFGLSVLFFMHLTSENIAAENPLTLKLRISMRVARTLTIFVIWLNCFFKQSQIVDTANSYLRMNTEAVKIYDDISKSKFKTKHVIFYILIVAHLILLVSSIATSYLCNGIFDIRILTNVFDFVISVHIFQYATILAVIKTKFESMRLKLAELAEIYNALQAYVIVEKDKYLKILLQVKTIQRNHAELADICDSISEIFGISVLFSLAYVFGTTVHYSYFVISQNFVHPNRKSMVYTIDTVIPLARFIVSITAFCVLANDVGTQQKNSTLHGENFIVEFII</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2EAB0</accession>
    <name>A0A8J2EAB0_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS1287</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001116">
        <property type="protein sequence ID" value="CAG5075128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2EAB0"/>
    <dbReference type="OrthoDB" id="7679028at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="267"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="508"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5075128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="560" mass="65350" checksum="7AF20E08BC8C9A71" modified="2022-05-25" version="1" fragment="single">SELIKLCFSKRTNPVVITDDLVDAIYGLSRDIDHPNVNVIDHNYQARQITIFNRTYPTYILPANSASQLKNLLHVLKSSPTWSIKTVFFIIGTNVESCGNASKMLQVLWKLNLISAFYVCYEPNDKESMMLYTYNPFTNRAPEPWVEVESTDRPDDRWSLYKQPYTNDKDACKSLTCKSYVSYAETLFSALNVTPIIYYDQKGYWNNHTASGYMTVLMDSTYNLALNIRKLQPIPKIDFINWNRQTYDMMITQRINIVRTVKNDETFLNFGTISVTILILVVTFVILVIHNGRDYGDGFLDIIRISIGSGIDAPLDKLPVRVTFIMTTLLFFVVTPDIQGQIFSYSTKPERSYPQNLKDLRDFKFNIHYAKHLKDFILEQKLVWNLNKTYLRPFYYHPAQCYDKVLNDSSNACLAVQSYQVQAAYDYNLHLAKKKKLNPAYISYWAKKDWVLKDKAQKETSKFLEMGLFDFWDKQQSKYIFEKFKAKETVENAGTEYDDIEFENLASIYLFIFLSYLLGILIFVTEILIVKYKAERHKKTIIRTLEKRVKYVGGRLIPIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2EB03</accession>
    <name>A0A8J2EB03_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative transmembrane protease serine 9-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HICCMSTLAB_LOCUS719</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001114">
        <property type="protein sequence ID" value="CAG5073947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2EB03"/>
    <dbReference type="OrthoDB" id="6755574at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000068">
        <property type="entry name" value="transmembrane protease serine 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050430">
        <property type="entry name" value="Peptidase_S1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033116">
        <property type="entry name" value="TRYPSIN_SER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24276:SF98">
        <property type="entry name" value="FI18310P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24276">
        <property type="entry name" value="POLYSERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00135">
        <property type="entry name" value="TRYPSIN_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6 8" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0720">Serine protease</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <feature type="domain" description="Peptidase S1" evidence="7">
        <location>
            <begin position="9"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG5073947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="195" mass="21286" checksum="99F8270922A5EAE5" modified="2022-05-25" version="1" fragment="single">TDTKRAKRLFNGNDVEPDEYPFTVSILLNNTHICVGITIGEKHILTAAHCFGNLPLVALANLVVRSGSIFYNSGGNLHSVKKIIYHREYRIGDTTSPNDIAILELNNPITLDDHCKIISLSSTFVQTGAIATVIGWGHTESLRKTNPSLKQLTLTILDPLTCQAYMPYTMYTHQICAIGFLNQGTCVGDSGGPLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2EBA8</accession>
    <name>A0A8J2EBA8_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS1788</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001116">
        <property type="protein sequence ID" value="CAG5075644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2EBA8"/>
    <dbReference type="OrthoDB" id="6677240at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5075644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="178" mass="20146" checksum="9380EB63583808C8" modified="2022-05-25" version="1">MLLNVEGSVVVSSLIHTSALAVINLNPGKIATPSRFYLPKPPCSVIPLFYSIFPDKNTRPVYEVMDGNDEHPRPIHQRVPIRDIDDINPEKFTRNPRVQLGESDWRIRKTNKNYPLAVSPLLSQYGNGYPAINSANVNVDTPRVYSYITVNNIHNNRPFGQYKWTHGFDSDPSGNDSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2ECL4</accession>
    <name>A0A8J2ECL4_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to NOF: 120.7 kDa protein in NOF-FB transposable element (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS1532</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001116">
        <property type="protein sequence ID" value="CAG5075378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2ECL4"/>
    <dbReference type="OrthoDB" id="7461344at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02257">
        <property type="entry name" value="Peptidase_C19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="USP" evidence="2">
        <location>
            <begin position="896"/>
            <end position="1169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="744"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="759"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="774"/>
            <end position="787"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5075378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="1171" mass="135438" checksum="A8857FB229021242" modified="2022-05-25" version="1">MPLKSQVSVEDAVNVLIRHISYFASEKLPEWSSDIWQVLAKEKEFQDKWNANSVRTNVRNDRRGILTKARQECGLFISNQNTNVDNGDDCDDDENSLSDEDDDKRDPDYFNHVYSDMKDKMETFELIFSRQLWDSINKHTPLIENKQTGAGFQPKVWTDTIAFELWKQYRLQCAFIFKKGSIHEHGHYYATMTGHCKSKLCQNFLFGYVENDPGDEGDVIIKINCCDTRFTKHENYRRPLRGQKRDEMKKEVKEKGVKGAVHDAAQKLLKPGDTHCPVMSKPNVLYQLKKETIEDNFGVDPKDRQDLIKTLLSIDQSPIYLHSMRVVSTKPFYVVYATPSQIHCYREYRRLHRNWSSVYIDATGGAAKKFDYNNNRTSAIFLYEIVINFSGTSVSVFQVLSEVHDADYITIWLKKWLREVKLPPHEVVSDGSRALLNAVSLAFNNRSLSDYNELCFNNIKGTTTIQPNTYIRLDTAHFIHAVSLWKCWKSVTHKNVKSFYLYCIALLIECNKWEEMERILILMLIICCTEYEDTVISYREEEITPRDARVELETLIGNRKIKVMVEDIEEKIKSMDIDSDKKDLLNDNLFSVSDDNLTIASWASHLTSYPTNILLTGNTLNCFYVPLFKDPLIKNVKEFPLWTKVCIPSNKLRPSSSYIEEDFKDLKKVLAKQITLPARIDIFVKAHMKYLLGGVIILQNKFTQFVDNNIDDCTMSIEDSNLHDEKFEEDVQNDEEFQDSLQNENWRGLGNDPKHAKNDWANYDNNDNQNDSDENSKADGTESEKLHSVLEIDEDEIEINVSESIKNDHDYTVIASTPLSNRIDNNNKLDNAIDKVSRKIKKEGKYFQDCPEIKLINDLIKLKKNKENIPTIQKKGKHKETYLLINGNKSGPVLYQGIHYIAYNTCPLDSIIQILYNGALENQSFTDYLSSSKNPAFILTMNLLKKGVNNNPKIYEKRFSILHQFYKALEPSQKEQGAEEKNNKTTTVSRVIDCEDNVTSLWNKLFKDDPSLIEIFTCVSQNCSYQLKKPTLGVNYQTLLNNGIKDLQNALIFHGTFKRFCPVCSNEQTCEQKPNVYIYIELDVRMRNEVQGLSCKLRDIPIILNIQENSIKTLRYRLCGAIGYNARHYIAYCRRLSGRWRFYNDLLSASEAIGNHTSIVPHGVFYLLDKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2EE34</accession>
    <name>A0A8J2EE34_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similar to Hemolymph lipopolysaccharide-binding protein (Periplaneta americana)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS2382</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001117">
        <property type="protein sequence ID" value="CAG5077144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2EE34"/>
    <dbReference type="OrthoDB" id="7655410at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00037">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050111">
        <property type="entry name" value="C-type_lectin/snaclec_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22803">
        <property type="entry name" value="MANNOSE, PHOSPHOLIPASE, LECTIN RECEPTOR RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C-type lectin" evidence="1">
        <location>
            <begin position="40"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5077144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="168" mass="18794" checksum="38896B2919409294" modified="2022-05-25" version="1">MVIIDYRILSIRTIESQCTDCVDTVVSQLKVQKPEGYKPWGNNLYKAYNVAKNWNNAQQTCQGDNGNLAIINSREEAQFVQQLVINARPITGSTYPGGWVGFRDSDGGANWQTLTGQNLNQAGYDVWWRKKDRAEKNKCGAIKICGRLSTVSCNNLIAFVCEIKPSID</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2EEI2</accession>
    <name>A0A8J2EEI2_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Similar to F38B2.4: Adenylate kinase isoenzyme 1 (Caenorhabditis elegans)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HICCMSTLAB_LOCUS2078</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the adenylate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001116">
        <property type="protein sequence ID" value="CAG5076097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2EEI2"/>
    <dbReference type="OrthoDB" id="442176at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019205">
        <property type="term" value="F:nucleobase-containing compound kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01428">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00235">
        <property type="entry name" value="Adenylate_kinase_Adk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000850">
        <property type="entry name" value="Adenylat/UMP-CMP_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033690">
        <property type="entry name" value="Adenylat_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23359">
        <property type="entry name" value="NUCLEOTIDE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00406">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00094">
        <property type="entry name" value="ADENYLTKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00113">
        <property type="entry name" value="ADENYLATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 5" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAG5076097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="190" mass="20965" checksum="0880F197F1AB0DC0" modified="2022-05-25" version="1">MTMKTIWVIGGPGCGKGTQCSKIIDKFGLLHLSSGDLLREEVASGSPRGASLQELMSKGLFVPTDVVLSLIKERMDKARGDGNIKGFLIDGYPRELEQGIQFEKDVCPVDLILFFDVKNETMKTRLLGRAAVSGRADDNEETIVKRIEIFNEKNSKIVEHYKDKVVKITAEGAVESIFDEASKALEPLFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2EG06</accession>
    <name>A0A8J2EG06_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Similar to TTC3: E3 ubiquitin-protein ligase TTC3 (Homo sapiens)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HICCMSTLAB_LOCUS841</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001114">
        <property type="protein sequence ID" value="CAG5074069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2EG06"/>
    <dbReference type="OrthoDB" id="8062037at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043866">
        <property type="entry name" value="TTC3/DZIP3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17550">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE TTC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17550:SF4">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE TTC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19179">
        <property type="entry name" value="TTC3_DZIP3_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="1 3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="5">
        <location>
            <begin position="1121"/>
            <end position="1164"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="648"/>
            <end position="675"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAG5074069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="1177" mass="136518" checksum="777AF67F877D6E25" modified="2022-05-25" version="1">MLIHLQPELIEKVNKHIVTIIKMPETCYQAHKCLENSEAVLMLQKAAEAYSSSLYQLAVTHYKSAIVLLKSTSDYEGSLLISVIQYLICKCLIETSQLASLIEAKDTLINLIETTDRLPMLYYLLSSLYIKTFCYKEAEKLINYCLAFLNSSTSITSFNIPTTNEVIPESTFEELSRLLVQLKDECSGWHRPDAICFMKNCNSTSLSNLLDRDIYFKSPAFNGLVVVTCNNNINPCVFNFHINCWKLKKEELSPNIKLSDKDFLNWKCFTPNCDNFDQSSVISKIDIYNSDHTIKSHVALPEKIVKQQQTPKGAVRKQKINNHKITLKITRPRNINNVISKSDNQSTNVKNKYKKIKNNDEMVLISHLIKLIQVRNSNYGIEQGKDWRPDLSYYGDSSMIVSEDMYPDIIDIEDENLKQQKDFLYSYFYEYVSCNAPVKKDTLMKKWEEAKTLISNCDLILYELKCPTVVEFLLKSMKFAMVGEYVCTPATLPDAYKRVSDNVCGILKCLMKKGGDSDSDDDDDDLVNEEFLKSLNSFDSSVRVDNTDDSTANDFKSEKIDDFKNQKINIDKNKNQKIDEINYQENDLKNIDENYQSFEKNLNFDKNSNFEKIEEKIIIENENDELIEDNFTEKLNEKSKTKVCTKTCKKLSEKLQKSKEELQNFQKNFSNLKKTFLKNMLSSDYSSKKNVLLFNIRLARNEYFIIDKLQTILIYSTGTMLPLSEVEWKTPIQQMEKLCFDLDDDYSKKLELLNDEEYCKTNESISCICNVLPPLPKRDLTLLIQIAFNLYRDNLRRVDPSFNQAPGYPPGFNQTSLYGSPMIYQQRPQFWNQISSSANFNSNYQQFMPRNNPVYAGWNSKLFAGNNIINNNNNINDQNNVNGQWSLKADIKSELIDINSKKEFINYDEINSKGSLSDMKEKTHAFNYTEPPESLNNDKVHKVHEVLIDNCEEDLKKVLEDWKSIWEDKSEFKDYKEEMGGDKKEVEEEEEMECELKEEIGKKKSYSMDKLLRELRAKHRGVLEYDLLYCVDAVRNKYNGSLSGLTLAEIIGEVEKVLPGRERLQLRNYDRRIFSKKQVKKLEKVQGAKSTIVKKSTSKSNPWATLDGYQWTNEDFGENECIICTEAIIKFGKVPSYTLRCKHTFHKKCIKNWFNQNQSCPICRIHCIIDDEFPPLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2EIP4</accession>
    <name>A0A8J2EIP4_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">HICCMSTLAB_LOCUS628</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="CAJNRD030001114">
        <property type="protein sequence ID" value="CAG5073835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2EIP4"/>
    <dbReference type="OrthoDB" id="193931at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12198">
        <property type="entry name" value="MELK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000571">
        <property type="entry name" value="Maternal embryonic leucine zipper kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000003">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.80">
        <property type="entry name" value="Kinase associated domain 1, KA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028375">
        <property type="entry name" value="KA1/Ssp2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001772">
        <property type="entry name" value="KA1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF30">
        <property type="entry name" value="MATERNAL EMBRYONIC LEUCINE ZIPPER KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02149">
        <property type="entry name" value="KA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103243">
        <property type="entry name" value="KA1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50032">
        <property type="entry name" value="KA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="11"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="domain" description="KA1" evidence="13">
        <location>
            <begin position="347"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="149"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="223"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="235"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CAG5073835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="423" mass="47229" checksum="C72876E2627C92C9" modified="2022-05-25" version="1">MVRYTALKGLYELDKTIGCGGFAKVKLGTHLATGEKVAVKIMEKAALGEDLPRVKLEIDALKTLLHQHICRLYQTIETSTHYFMIMEYCSGGELFDHIVEKNRLTEHESRKFFRQIVSAVAYLHSLGFAHRDLKPNCKNMRNENEVKTLITQLDNSPRRPLTVKSTGKSEATRGLSPIPDIKKPSAESPASGARKRVHDTNEEDDSISPTVPVKRIQMDKFNDTVPVTPKDKNKLTQGTGTNATPGSARKVIIGLERGLNRIRDVLTPKRKLKCVNNDNSPDQPIVLSGKGLCNVSSTSNNCPKDVLSQLRRALQRKGIFCRQKGFILQGETEVYDNENIKQGQRAFGNQRKICSFELEVCLLDGFSTNDKPVVGIRRKRLKGDAWVYKRVCEEILALAAEDVKTTDQDSVESAKTPSGHCLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2EKQ9</accession>
    <name>A0A8J2EKQ9_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cc_58b</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS1912</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001116">
        <property type="protein sequence ID" value="CAG5075888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2EKQ9"/>
    <dbReference type="OrthoDB" id="7697662at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035144235" evidence="1">
        <location>
            <begin position="23"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5075888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="409" mass="47379" checksum="447E88CCB1ABB3AF" modified="2022-05-25" version="1">MLNPEIIFTILMVTTTIIMVISNNNFDDCKFVNLRFDDHEARNLKVSILSNQEVLETLDLKESDGLLADFSTPVVSFSNETDKNYEAYEFEHSTIAQFAPNLGYFTLYRDQPKMAALVYSFRKPTDFSLDGNIGHYVLRHLPNSVDNSRYIYIKLLDAYQALPDAPHEVGAELKFDLGAAHLDTIIVEMVVLIDSQESNTTPTEMIKKILMYYNYIDMLYCNFERPKVGYKVVGIVIPKFKIGNSNSEYITSSEIKNIQEFIERQKKRFSLNNFQLVTVMTQRLILLSHNPLKVTQASKYEEILFKKLKNKSLKSTFVYFLVTVNEHKICETGDKLMMIWALDVDFQAGHGIWVSQMFSKFAPDHFDEGMKVKCRNFTVNVQPDNLNLMTLWPSCVIREYSNYFKYVII</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2EL16</accession>
    <name>A0A8J2EL16_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similar to Brd8: Bromodomain-containing protein 8 (Mus musculus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS2331</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001117">
        <property type="protein sequence ID" value="CAG5076950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2EL16"/>
    <dbReference type="OrthoDB" id="1742084at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035267">
        <property type="term" value="C:NuA4 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15398">
        <property type="entry name" value="BROMODOMAIN-CONTAINING PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15398:SF4">
        <property type="entry name" value="BROMODOMAIN-CONTAINING PROTEIN 8 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="128"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="277"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="428"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="560"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="824"/>
            <end position="870"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="288"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="429"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="481"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="519"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="567"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="580"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="627"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="664"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="689"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="723"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="752"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="828"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="861"/>
            <end position="870"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5076950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="870" mass="99643" checksum="186A5B7DBFCB9E2E" modified="2022-05-25" version="1">MEYKRATIVLKSGDQNWITVSRSLKPFAEKEALRPPDWFSHKACANQYTRLLENVDTPKRKKRESGDTIGESIVKRLTQERTAELGQILAFQRDEYQQLKSEVNLLKSGSISDDKLQKMWQAIEQEEREQEQKAKAHSVWLAKRQQKQDLTSQSPAPLTPLKKTLDLNDTPEDTNDEEEKKRGSSTLLTNLLKAPSPTKQIQNATSTAQVTSPTIASLLNSSGSVHMVSSAPQNVTAPIHHIVTSVIPSGTPERPSAGAPTLSMLLALPANLPKGPLPTLPAAKSDTETSVRSSGTKSVNQAPAIQLSNAEAEIANSDNVGEIIEQIDDVIGKDNLPDVIDKDEINEIMEDIEELIKEEITKSPQTEVREVVSKGETFPGVEKNEEVEAKVEKTISLTDSPESEMAIEEIEHSSSNIAEIIGTSIETSKVAHQEKKEEKEEIEEVGDKIEEEVKKEVEGEGKVGEERKEEEKMEVEEDAVEGEKVEKEEKEEVEEVEVKEGIEEVKEEEMEEKNKVEDKEEEEEDKKEEKEEIEEICEKKEDVGKEDKEEWEEEIKEAKEEYKELKDEVEEEKVEEEVGEDKKVKEEKKEVEVEEKKEGSKEEIVVEEVNKEEKEVEGEKNEEEVKEEISEAEKEEEKVEEKEDKEEKEVKGEEEVKEEEKEEEKEVEKEEEVKIEKKEEEKEEKEKDEKEEEKIEDLEVEDKDEVKDEDEEVKEEEAEESVEEMKEEKEEKEEVKEEKEEKVVENKDEEEKEKVEKIEEKVETKEAEEVEVKKEESVTLPENLQPEVEEESSLIKLSGGRAMKTYSKKQNMLVGVTKDVSFRRETRTAGSSNSEFNEINILKRKRSHITPSPHDSESPRLKKRRKSEND</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H2H1</accession>
    <name>A0A8J2H2H1_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS1431</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001116">
        <property type="protein sequence ID" value="CAG5075277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H2H1"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5075277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="64" mass="7458" checksum="0EDF564BC92BF871" modified="2022-05-25" version="1">MKLIDCEVITLESLWAKANQPNFSSLVWEEHHCIISTQESGTWEAFAKLENRDNSHEKENKNAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H429</accession>
    <name>A0A8J2H429_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to ORC3: Origin recognition complex subunit 3 (Spermophilus citellus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS2026</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001116">
        <property type="protein sequence ID" value="CAG5076045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H429"/>
    <dbReference type="OrthoDB" id="10265211at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031261">
        <property type="term" value="C:DNA replication preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005664">
        <property type="term" value="C:nuclear origin of replication recognition complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005656">
        <property type="term" value="C:nuclear pre-replicative complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20704">
        <property type="entry name" value="Orc3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020795">
        <property type="entry name" value="ORC3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045663">
        <property type="entry name" value="ORC3_ins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045667">
        <property type="entry name" value="ORC3_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12748">
        <property type="entry name" value="ORIGIN RECOGNITION COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12748:SF0">
        <property type="entry name" value="ORIGIN RECOGNITION COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19675">
        <property type="entry name" value="ORC3_ins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07034">
        <property type="entry name" value="ORC3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Origin recognition complex subunit 3 N-terminal" evidence="1">
        <location>
            <begin position="22"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="Origin recognition complex subunit 3 insertion" evidence="2">
        <location>
            <begin position="312"/>
            <end position="536"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5076045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="580" mass="66448" checksum="33D02CCB17292E0E" modified="2022-05-25" version="1">MDDVSVSKGIFAHPGRYTIGSNRKRSKSVSNCKFSEPWYLAYEQVWSTIKNCAEEINTDMFKQILTDIKKYMSDIKENNSSDFLNEIPTAILLTGINLPDHDELFRKLALQISGITNYIAVVQSRDSASIKSLTEDMVFQLINGSDQVPIVKKSQCTLRVLEAWYKEQCTDTPLVIVIPDFESFNPIILHDFILVLRRTMKFVLIFGVATTLHAVHRSLPYDATSKLRVQVFYTQTQVKSLSDILEGTVFSGKTPFMLTGRAFQLLTDIFLFYDFSVDSFLQGYKLCMFQHFFGNNLTSLCCNRKTIDQAIGKLSTEDLDDIRRLPSVVKYTEKHKIKGKEDMDDESLKWLVGKFLQQFHDSTSGFFIILKCLHYLVSSLPGSPLGKQLREIYATAVTCDLTETQEYKECIKLLNFLSKSELVTKLEKIIKIIEDNHTEEINFNGVIENLKMHLEKIKAASLEISSEVTPVATPTMKISRTSFRENLLNKAQKSSKSEFKQAQLNLMNYLNDDLFMEYLKNPNRLPCSEIFCFSDANAGKHHLRVRLLQIRNRANDSTDVTRPQHYLQAAFGVKEIDQYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H533</accession>
    <name>A0A8J2H533_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Similar to rnaset2: Ribonuclease T2 (Danio rerio)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HICCMSTLAB_LOCUS935</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the RNase T2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001114">
        <property type="protein sequence ID" value="CAG5074163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H533"/>
    <dbReference type="OrthoDB" id="7665994at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033897">
        <property type="term" value="F:ribonuclease T2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006401">
        <property type="term" value="P:RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.730.10">
        <property type="entry name" value="Ribonuclease T2-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001568">
        <property type="entry name" value="RNase_T2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036430">
        <property type="entry name" value="RNase_T2-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11240">
        <property type="entry name" value="RIBONUCLEASE T2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11240:SF22">
        <property type="entry name" value="RIBONUCLEASE T2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00445">
        <property type="entry name" value="Ribonuclease_T2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55895">
        <property type="entry name" value="Ribonuclease Rh-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="374"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU004328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG5074163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="424" mass="49792" checksum="1AC5487271A5CC5C" modified="2022-05-25" version="1">MFSEDDLHLGFSIQYNYTEKQWVAVDLILRNNASYTSCINGTLWSDDWERPNPYPTLEDTWTDFGPCFTKIELLNDKSKYLSEASRLFNKYNMNDILNQSNITHGNNYTYQEISDAVSKATHGIKPAVKCFHNHFYRSGNNLVLDKITLFFDKSFNLINPLKHHYRGMCSTEDENGYYLLSQKAYPADCPRYCRNSTKCQKPKYSWIIREFTFMFKDNIEFSCDTDDPHHYDAKYNLTSLSSIKNEIVDKWEIKEDNYNCDSKDVLIRKYWEKQGMCSAYFKELTNEFKFYNKSLELFDKYNMGTILRQSNIVPGKNYTHREIHDAVAKGIGGKKVRVRCDHHFFGFQVLSIVEFVMDKNFNPTNPIDRLLNSLIGRALSMFMSVIVIKLYFIRTLTILSRKKGKMRNGQEKNLVTFIPIESQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H5T3</accession>
    <name>A0A8J2H5T3_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS1995</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001116">
        <property type="protein sequence ID" value="CAG5076014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H5T3"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5076014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="163" mass="19623" checksum="27D2AF2269580F2B" modified="2022-05-25" version="1">MDPINEAHQSLSESMLSYWLPLLEMYNIVIQRVKLTQKYYNDLYFHEREKTQNNSQNYTGDPWFIEYALIGFYQNFDVFSKKLKKCIDKIQREIDKVKIILSKKHFKTSFNFVNRFNQSVRYLNRVIEFLNKNEFKIDNIVLSKSNFLKPLEVINNPKDESSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H6C5</accession>
    <name>A0A8J2H6C5_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS2679</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001117">
        <property type="protein sequence ID" value="CAG5078224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H6C5"/>
    <dbReference type="OrthoDB" id="8192916at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012464">
        <property type="entry name" value="DUF1676"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21879:SF22">
        <property type="entry name" value="FI03362P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21879">
        <property type="entry name" value="FI03362P-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07898">
        <property type="entry name" value="DUF1676"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="151"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="177"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="215"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5078224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="286" mass="29948" checksum="5616DC8AF3BA85B1" modified="2022-05-25" version="1">MGRRIFVPILWAIMAVVVLGLPADNKSGDNDLMATIYSDCSKNDAVNCIKVKFFNFVDKMLTDKEDITLSEGITVVKTSTAEEGAPRSIDSTDVDTLIFDRVGRFLKTHSIKVDLKGSDILGVVESAGRSLDDLSDSLVEGRGKKKKQQKMMGPIMMAMALKAAALMPLALGTIALIAGKALLVGKIALVISAIIGLKKLLGGQKHVTYEVVAHPHHSSSSSHVVSHDDGGHGGGGGGFSGGDFGGGYGGGGSSSGHGWARSLPQDVHQHAQQLAYSGQMPVQAQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H6D3</accession>
    <name>A0A8J2H6D3_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS2777</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001117">
        <property type="protein sequence ID" value="CAG5078557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H6D3"/>
    <dbReference type="OrthoDB" id="90756at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="444"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="450"/>
            <end position="487"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5078557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="649" mass="75006" checksum="30522EA1B6F504EA" modified="2022-05-25" version="1">MTSLFSYEGHQFNLDGRYNVNGNQRYRCLYFDSVRRCPVKLWRLTNGRMLQIGQHNHIVHQIQPDQPPERRPAPRVRNTNRRQPARRQSLPPTPSTFEELEEILLVLRAADDIYQGHVKDNSSMAYIFSTDRSLKLLSESSEWHINICFQCAPLMPQCSFLLTILVRRENLGVPVFFALCNENTSKLFGLIWAWILEKVPDTRNNLKYTISDVDRSLLSSIKLWLPFAERNGSWINAARALADKWRSLQLPNRDKPLSIILNSSWAISFVPEEKLNEAIDILANMLDAHDNGTQNFTQFRQFLVREYLPVANYLSIWGKPWKAASFTETYYNKLLHHFGEEHPTIFHLIPKLSTLIGTEVNSSWTPRARRSNSDHYVFETATVLSSRLHGGQCSLLDYLKIIGFTRKEIRTTLDVAVDRQRYLYQNLAQFEHRLDLLGSRNFVNRAPEPEPAEVEDELVETEDQPAAVEDEPIEIEEDRPEEIEDQPAEPRSENDDDNIYYRGEIQLLDEPEQLPWINSSTQGMEFNDEEADDFVLACVACRINRPKAAFSPCGHSCLCLECNLSNADNIRSHTSRQVIHRQRPRYRPPIPQNFKDLGETLTVYRMVSNIYQHEVIAEDGSIAQIFGSNNMLQRLGESSTLLNLEEASR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H757</accession>
    <name>A0A8J2H757_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Similar to Aplip1: JNK-interacting protein 1 (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HICCMSTLAB_LOCUS3287</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the JIP scaffold family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5081442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H757"/>
    <dbReference type="OrthoDB" id="5965083at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008432">
        <property type="term" value="F:JUN kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005078">
        <property type="term" value="F:MAP-kinase scaffold activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007254">
        <property type="term" value="P:JNK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046328">
        <property type="term" value="P:regulation of JNK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01212">
        <property type="entry name" value="PTB_JIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11801">
        <property type="entry name" value="SH3_JIP1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000032">
        <property type="entry name" value="Putative C-Jun-amino-terminal kinase-interacting protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000306">
        <property type="entry name" value="Uncharacterized protein, isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047178">
        <property type="entry name" value="JIP1_scaffold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006020">
        <property type="entry name" value="PTB/PI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47437">
        <property type="entry name" value="JNK-INTERACTING PROTEIN 1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47437:SF4">
        <property type="entry name" value="JNK-INTERACTING PROTEIN 1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00640">
        <property type="entry name" value="PID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14604">
        <property type="entry name" value="SH3_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00462">
        <property type="entry name" value="PTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01179">
        <property type="entry name" value="PID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="8">
        <location>
            <begin position="303"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="domain" description="PID" evidence="7">
        <location>
            <begin position="450"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="9"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="162"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="233"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="38"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="253"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="274"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS01179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAG5081442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="522" mass="57119" checksum="B4340558161BA781" modified="2022-05-25" version="1">MCLVHDVLVDDSPTSSQASDNEDNNSCLRISTAATGAEDSDDQDDQDAQGMGINQHDNQSDDISGDDSEDFDHNSSIVADSDFRLEYRKHGVVLADCSLLCTFDDISLFGGLSSRTRYNSGGKNGSRIINSGPQSDCSTVVSDSVGGSCSSLATGSSCWPTPEHAANRSVSSANERRRRRLPEIPKSNINTNNNNHKSMIGFVSLQTSPASLADELAGVSGATGAGRPHLILRKCHPRLLNEDSSPDSERMTTDSGHSTAHSPDNGPKSVSPIMCSNTLQNTDSVSPSSTPGSGGIPFTQLELLEATHRGLHKFIPRHHDEIDLEIGDPIYVQKEADDLWCEGVNLRTGRQGIFPSAYAVDMDYSDFDPTAPKVKRERYLLGYLGSVETLAHKGTGVVCQAVRRIVGNTASDSPESQSCILEVSDQGLRMVDRSKPRQRKNRGPCHDYFYSLKNVSFCAFHPRDHRYLGFITKHPTLQRFACHVFIGQESTRPVAEAVGRAFHRFYTKFIETAFPIEDIYIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H7M9</accession>
    <name>A0A8J2H7M9_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Eukaryotic translation initiation factor 3 subunit I</fullName>
            <shortName evidence="7">eIF3i</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HICCMSTLAB_LOCUS3508</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the WD repeat STRAP family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the eIF-3 subunit I family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5082267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H7M9"/>
    <dbReference type="OrthoDB" id="24966at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071541">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex, eIF3m"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000127">
        <property type="entry name" value="Eukaryotic translation initiation factor 3 subunit I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03008">
        <property type="entry name" value="eIF3i"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027525">
        <property type="entry name" value="eIF3i"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19877">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19877:SF1">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24805">
        <property type="entry name" value="EIF3I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 7 9" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5 7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 8" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="2"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="44"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="146"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="181"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="278"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAG5082267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="322" mass="36156" checksum="AD1F287E6ADC6B3B" modified="2022-05-25" version="1">MLHGHERAITMIKYNREGDLIFSASKDKKPNVWYSLNGERLGTFNGHNGSIWCIDVNWDTSRFISGSGDNSLRIWDCQTGKEIGQLDTNSSVRTCAFSFSANTAVFSTDKALGHQCEMFIIDTRTVEPTLSLDDAIIRIPINGPRISAIVWGALDESIITGHEDGEINIWDVRTGKKLNSQKGHKSQINDMQVNKDGTMFITASKDHTAKLFDSESLMHLKTYKTERPVNSATISPIYDHVVLGGGQDAMDVTTTSTRQGKFDARFYHLVFEEEFARLKGHFGPINSLAFHPNGRSFSSGGEDGYVRINTFDQSYFDFHFEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H7X2</accession>
    <name>A0A8J2H7X2_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Similar to ASB2: Ankyrin repeat and SOCS box protein 2 (Bos taurus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HICCMSTLAB_LOCUS3673</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5082875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H7X2"/>
    <dbReference type="OrthoDB" id="6783053at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="116"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG5082875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="390" mass="45164" checksum="034FE8EB4609C603" modified="2022-05-25" version="1">MNYNFLRTEIVTKSLSVNVTIKLSAEFQPLYFEYTRRKKCELTILHLAICLDDEPFVDYLLMNNADVRLSTENVGPVIYTAIRLRKLKYVHKLVDYAGAEFLISRGAEVNYEFLWDGPSPLSIAAGSNNLKMMKLLMKYGADINFVDESGYHDPPLFSAITNFQNFEAVKFLISQPTIRINYQDEDQSLCLHILLKSEDLDGIFTTHDTILESLLDAGIDVNLKNGDEQLAIEMETEENRVYIIKIKQHIVKLMTVNFYVSAKNANAVSGTEFQQLRVQCAKQVEILKITSGPISGFSYYDLLHKCQHKLTLRFKDGDGDKFDEEMRRKFDLYEGMIAHRLEKASQRRELFIKVENVLYEIFNRKLPATFIHDMFFYLSNDELFKLSKNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H814</accession>
    <name>A0A8J2H814_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Gamma-soluble NSF attachment protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">N-ethylmaleimide-sensitive factor attachment protein gamma</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HICCMSTLAB_LOCUS3530</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNAP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5082332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H814"/>
    <dbReference type="OrthoDB" id="26569at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005483">
        <property type="term" value="F:soluble NSF attachment protein activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019905">
        <property type="term" value="F:syntaxin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000477">
        <property type="entry name" value="gamma-soluble NSF attachment protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000744">
        <property type="entry name" value="NSF_attach"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13768:SF2">
        <property type="entry name" value="GAMMA-SOLUBLE NSF ATTACHMENT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13768">
        <property type="entry name" value="SOLUBLE NSF ATTACHMENT PROTEIN SNAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14938">
        <property type="entry name" value="SNAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="287"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="297"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="328"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="340"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00040047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00042485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAG5082332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="365" mass="41196" checksum="A84093A413B011AC" modified="2022-05-25" version="1">MSKIEEGNAHMRAAEKSLKTTLLKWRPDYEVAADEYNQAATCFRIAKSFKQCKEALVKASDCYKENRSWFHAAKSLEQVLLICRDMNEMSEVPKLAHRSCSLYQQHGSQESGATVLDKAGKMLESSDPEAALPLFQRAAEIVLGEDSPRQAAEYLSRVARIFVKLKKYDEAANAIRREIDMHQRIEHQPSVGRLAVVLVLIQLARGDQVAAEKAFREWGNYCDAPEIQTLEMLLQAYDNEDANAARAALNSPFIKHMDVEYAKLARGLPLPQQEYAVPPAGVRPNAAEPYVSSSVQDKQRETVRAEVSHETEPIEKAMAATNITKELGEDEEEEEEEEKEKEKTPSPVEEKDKSKDYDEYEEGLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H975</accession>
    <name>A0A8J2H975_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Similar to RNF17: RING finger protein 17 (Macaca fascicularis)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HICCMSTLAB_LOCUS4744</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5088173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5800423at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd20379">
        <property type="entry name" value="Tudor_dTUD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.90">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035437">
        <property type="entry name" value="SNase_OB-fold_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002999">
        <property type="entry name" value="Tudor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16442">
        <property type="entry name" value="RING FINGER PROTEIN 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16442:SF1">
        <property type="entry name" value="RING FINGER PROTEIN 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00567">
        <property type="entry name" value="TUDOR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00333">
        <property type="entry name" value="TUDOR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63748">
        <property type="entry name" value="Tudor/PWWP/MBT"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50304">
        <property type="entry name" value="TUDOR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tudor" evidence="3">
        <location>
            <begin position="711"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="domain" description="Tudor" evidence="3">
        <location>
            <begin position="1011"/>
            <end position="1066"/>
        </location>
    </feature>
    <feature type="domain" description="Tudor" evidence="3">
        <location>
            <begin position="1308"/>
            <end position="1368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="154"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="634"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="886"/>
            <end position="934"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="41"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="159"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="181"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="635"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="895"/>
            <end position="909"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="910"/>
            <end position="927"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG5088173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="1446" mass="165411" checksum="2BA40BF3CF295FD5" modified="2022-05-25" version="1">MKEEDYSTEGIEVEISKSFVHIHGVLQLLEERMMQVVYEERRKERTQLEEIDNSLQVLKEQLESAIVTAVFAKKHSENVSHQMIIDEFKELLKLPCHLVDPQNPSKQSNLKFQINSEEIIETIKNNCDIIMVSSNDSYKLVCIDELQNDQVTDRSENLSQIPPEVSPPSSETSGSSGRQSLTLNSESESSVIESDTSAMHSVEGSAKSIRTTEKQIRNGIEVTITHIDNPNAFYIRAKMNDGKFRELEKKLEKYNEVNTQVPRKIVEGGLYVIHRSGNPKWYRGRIMGSKSAEGPVYYPVYQVFAIDHGFTDVEVGIANVRNLFEDLLDIPPLVQKFSLYDISPIGESWCHDSVAHMEEIIDSAERAPILYTTKEGGKDLLIPVSPTTFPLSLRDALIFLGYGKFISTARLYRINPSASNVFHHEHLTPDQLFDAVYLNSYSPECIYVRKASYNEHYFENMVQKMTEDYKSTKRIKGYIYCPETGMNVAVPHENSWYRGVIVDVVGVRVIEVLLVDLGINTTIDYQKIRRLDSRYTQSTVRAIKLSLKDAKPLDPAEGWSPETNAAIKQFMNPINIQVVIYDSVAIDGFLHHTASIINKNRLSLALYLQYLKISAQTVSTGVLEKMQSRFMGIQSKKKSFNRRKSSKKPKNQPKNQLPKLEDPYKVQVVISLVKSPFEIYVTSVHESTAINDIVKKMQRFYETHSTDEQVKLVEDTVCAVYSKDHNCYYRAKIKKVISPEEVIVFLIDYGETAQVAASDLLSLGAELYDIPIHVFKVKLAGIAPCGGSKSWTASSIQSLQELLDQNGDFFISKVAESEDDAMLVDMFFQQSIVDDPCAPARSETWTINRELVDKGYALPIKGFSDRKLKVLASDLHEEMNFSSCDLSKLGTSNESSEESEGGENDEDPEDPKGETKSQDSEKTLKDEQEVEENPEFKEVPFPNFAAFPKGIPQWLPAEPIELSEPFNALVTDINWDGYLHLVPIKNNCDTIRWIENTLNQKFRDSAWKRETWNIGDMCIAKFQDTWSRALVHRVQEKIAIEYIDYGNMMWQDEKFLRKELLLENIPRQATKCKVYEMTPDTPNKIWRQEDLDKLHVLLVDKVCQVTIVSQSPEVLVNIELLEPKCNLITYLTENFIVKLRKVMSDDVMLNGKNYKIKYGGQLEELEDEDDSESDNSDDVIIEIENMTDLDLQSMEHEANLETENDHENDNDDDLPENDLSILIVKELGLTNGDFIPSEGSNYPIFTLPVEVRSFEAVMGHVDTSKPNIVYLHPISSKDHPAFQYFKKKYDAMMYDIGFNIGGCSTLPFFEIGDPCLAVYSKDNAWYRCTIMTDRGTDGLTQVEFIDWGSVEWKSKEEIRKIPKDWMKVPRMAIKCRLWNTRVTDNSSGAVDWLHKACEKVKFNVQVVKRENGCTVVQIYDMKNPQRLFYQPLIDRRVFEAELKDIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H9A3</accession>
    <name>A0A8J2H9A3_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS3661</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5082824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H9A3"/>
    <dbReference type="OrthoDB" id="6152532at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5082824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="121" mass="13882" checksum="4F2469BA3337244A" modified="2022-05-25" version="1">MSDWQAYGRQLVLEMSELKDSANVSSSLTPLSRLLSEETTRRTSRNAAECLAVLEERAKNVSHLDYVTHAVQRAKRLMEEVGNAATRLENSFESRRTTIRNFAVLRSIEEQAQEEIFLKHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H9S0</accession>
    <name>A0A8J2H9S0_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS4601</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5087759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6382824at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004402">
        <property type="term" value="F:histone acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20916">
        <property type="entry name" value="CYSTEINE AND GLYCINE-RICH PROTEIN 2 BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20916:SF26">
        <property type="entry name" value="CYSTEINE-RICH PROTEIN 2-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="74"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="170"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="236"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="425"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="725"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="893"/>
            <end position="912"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="931"/>
            <end position="989"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1018"/>
            <end position="1121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1156"/>
            <end position="1182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1200"/>
            <end position="1325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1375"/>
            <end position="1443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1530"/>
            <end position="1589"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1619"/>
            <end position="1643"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1668"/>
            <end position="1696"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1713"/>
            <end position="1733"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="110"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="75"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="191"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="241"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="425"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="446"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="741"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="788"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="839"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="974"/>
            <end position="988"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1021"/>
            <end position="1037"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1050"/>
            <end position="1063"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1100"/>
            <end position="1112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1156"/>
            <end position="1167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1213"/>
            <end position="1234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1242"/>
            <end position="1253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1273"/>
            <end position="1286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1287"/>
            <end position="1312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1315"/>
            <end position="1324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1397"/>
            <end position="1424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1428"/>
            <end position="1443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1533"/>
            <end position="1542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1545"/>
            <end position="1573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1574"/>
            <end position="1583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1619"/>
            <end position="1636"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5087759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="1804" mass="204375" checksum="153E9DCBC87F5F52" modified="2022-05-25" version="1">MYAYICVVTTRELNMYLGDVDNNKIVIIRKTMMILLITWLSLSTLVSVESSDRWSRQTSNSEWIPLARPRSALPHQTPVVSSHSQSPSGSALLHNPNNNIQSLNLPPALQQEYQQQLMQLQKTQESIQKLLLLQQQLRSQQQLLQNQAYLPNAVEENKQPFRQNAIPNRQVDYNSEGAPPQLSSDALPPVYSSQQFKQSQEAAIEGGVPPSGPASDGKGENTDEEIQVVYVPAETLAQRGQSKEERNRDHNQFSFPRHDNRYPHPQQIDSSPPVTTEEPYSQEYVEFPRGQQAIEQFYKEARQKELDRLNEERKEIARQAKIAAAARQREQERAHQRDMDKKLKELAKIEELAKQRELERIREDRLRERQRLDEQEKVRMKEEKARQAEIERLAALERQKNAEIERSILRQKELEKAALQQEEVRAEELKSSEELHQQHHSENIKHKGPRHRSKPRRPHKDEVQEASTIPPPNQPPLAVFMGPDLEAQETQPQFQVIDALRFLRDAKTIPVLDHVSSTNPRVFVGPANLDPPQGYSKFDLPYLSSLDMNRVERRVDKLPFFVAPLSFSPPVGYYKIPFPHPHIGSVIVNSLDDNIGPSASQENSKTVPNVIDHNLPVSGPGPYQASYELASRAPYPNGYPSATPQYPYPSSSGNEGYLRGYEQQSVTPYPQSEEYATTTDYRKPNIVSSYSYDTAPTTPAYQDGYAHTRVQPNKDQEITSQLAQVNQHDYSQHRHAENPYQHPSQQASHSLNPHHGIYHLNPNIQNSYEEIDARPVGPNGNGNSNANVVPMTGGRVTVRTTTPSSTSITPTGSTQRNYERTRRPFNRSRSRFTTTTTTEEYKDTYEPSRSKVPETTIRYTTQEYRRPANKIQKFKNRNHEALNQIPNIQAHETLSDDGSIPEDPTNPRQYQNYNVPLTTVSSLTYSDESLTTERDYSKNPNYPHLSHDRFRGSDNGYQANLQAQGYDYDAPEGANINSNNNNAPSTPISVTPEYYYADKTESAEGVTDIPYSQVEYRPSINYNNNNNNNNNNNNNNNNDDRSSTSGENSPTTTEAPTTTEPAPVIIRQRVRARLGGRPRQDSPIQTAPRGSQDEFVHFSAVNQPRQQSTTARTRPRAKKPNYLTAAQVQSEGNDYVRIQSANRPHPKTIVQAAAPKTTTTTLAPASEESSEEEYGFFRKPNFNQPHNLISSKFRAPESPIQLQNVGPTDGTAADSSPTHTQVPTKNRQKYQTPSRPRPVIKSSTASVTTTPSALDTQSFTTKPRVRAEEPKNRIRTRVRRPGRRRTTTTSTTTEDPLDENNNLPLEENYPRLPIHPKESRDSAERQSIYDGNYETLPVNSGANGPSRSDYVYENYPNQDREFMLNFGASDIVEEQQDQSSLKLSKNHHDESRLRPYSRQQPSDIYGSESQWSTKLTQSSFQPVNQLPEEDKLPREQKEISAKKEDAPEIITARPDDGFMTVLVSSDNQTSTPGLDMTGETTMPTDFGMKMSAEESIRIRVRPSPPDDFVTAESQHFNSAVNNLVQEQAKPNEMSPQYNSNPNYEPPSSEVSTESITTTPTTSSVTPDSTTIITETKEQKHETPESASIPLINETTELVKSDSDDYNPGVTEITESAQTTSYETTTFVESSTESTTVPIPPEIPRKSWDSTKAYTDWLTRKMEKTLKSEQFLKKTSAKEDKEAQEGEEEHPKNHRSEWSEVRYPDRSIFGFGRSIVPRRPGRSPKPAPAARSMIASPGPGKWTVCRHSRPEVCVWRLVVESSWMYVTYSRAGGAIDRPFCCRHILLKKPILSLHIIGHVRVHQRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HA22</accession>
    <name>A0A8J2HA22_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">3-oxoacyl-[acyl-carrier-protein] synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HICCMSTLAB_LOCUS4467</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 8 10">Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5087267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HA22"/>
    <dbReference type="OrthoDB" id="5334845at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00834">
        <property type="entry name" value="KAS_I_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.47.10:FF:000009">
        <property type="entry name" value="3-oxoacyl-[acyl-carrier-protein] synthase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017568">
        <property type="entry name" value="3-oxoacyl-ACP_synth-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000794">
        <property type="entry name" value="Beta-ketoacyl_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03150">
        <property type="entry name" value="fabF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005589">
        <property type="entry name" value="PRK07314.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11712:SF336">
        <property type="entry name" value="3-OXOACYL-[ACYL-CARRIER-PROTEIN] SYNTHASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11712">
        <property type="entry name" value="POLYKETIDE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000447">
        <property type="entry name" value="KAS_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="KS3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52004">
        <property type="entry name" value="KS3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6 8" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2 8" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ketosynthase family 3 (KS3)" evidence="11">
        <location>
            <begin position="5"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="active site" description="For beta-ketoacyl synthase activity" evidence="9">
        <location>
            <position position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR000447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000447-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS52004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAG5087267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="426" mass="45197" checksum="71246161F23ED6EE" modified="2022-05-25" version="1">MNKYGRRVVVTGLGVVSPLGVGVKSSWNALLAGKSGIVKLNTPEYETIPCRVAGQIPKGNAPGSLNLDEKFSKSELRSMCPATAYALIAAEEALEDAKWKPDEETHKRDTGVAVGIGMVDLVDVCSMYEAMKKSYSKVSPYFIPRILPNMAAGQISIKYGFRGPNHSVSTACATGAHAIGDAFRFVKGGETSVMVCGAAEACISPLAIAAFCRLRALSTSKNDRPEEASRPFDKDRDGFVMGEGAAILIIEELEHALARNVNIYAEILGYGLSGDAAHLTAPSEDGVGAILAMDRACKNAQVDLNDITYVNAHATSTPIGDAVELKAIETLFGAYSKNVTVSSTKGAHGHLLGAAGNLEIAFTILAIKNSVIPPTLNLHNLDYSGPLQFVPHVKKNWSSVSKRTALKNAFGFGGTNASLCFTEFVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HB81</accession>
    <name>A0A8J2HB81_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Similar to Frq1: Frequenin-1 (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HICCMSTLAB_LOCUS4165</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the recoverin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5084651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HB81"/>
    <dbReference type="OrthoDB" id="191686at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008048">
        <property type="term" value="F:calcium sensitive guanylate cyclase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007268">
        <property type="term" value="P:chemical synaptic transmission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007528">
        <property type="term" value="P:neuromuscular junction development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000078">
        <property type="entry name" value="Hippocalcin-like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000072">
        <property type="entry name" value="Hippocalcin-like protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028846">
        <property type="entry name" value="Recoverin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23055">
        <property type="entry name" value="CALCIUM BINDING PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23055:SF198">
        <property type="entry name" value="NEURONAL CALCIUM SENSOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00036">
        <property type="entry name" value="EF-hand_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00450">
        <property type="entry name" value="RECOVERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0106">Calcium</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0519">Myristate</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0691">RNA editing</keyword>
    <feature type="domain" description="EF-hand" evidence="8">
        <location>
            <begin position="47"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="8">
        <location>
            <begin position="83"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="8">
        <location>
            <begin position="130"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAG5084651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="177" mass="20618" checksum="FF6A948B8B7CA832" modified="2022-05-25" version="1" fragment="single">YTRSEQIEVTEKEIRQWHKGFLKDCPDGLLTEQGFIRIYKQFFPQGDPSKFASLVFRVFDENNDGTIEFEEFIRALSVTSRGNLDEKLHWAFRLYDVDNDGYITRDEMYNIVDAIYQMVGQQLHAEDENTPQKRVDKIFDQMDKNHDDKLTLDEFREGSKADPRIVQALSLGGGDPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HBE2</accession>
    <name>A0A8J2HBE2_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Similar to TBC1D31: TBC1 domain family member 31 (Bos taurus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HICCMSTLAB_LOCUS6416</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5092879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HBE2"/>
    <dbReference type="OrthoDB" id="5578278at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051570">
        <property type="entry name" value="TBC1_cilium_biogenesis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19853:SF1">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER 31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19853">
        <property type="entry name" value="WD REPEAT CONTAINING PROTEIN 3 WDR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="664"/>
            <end position="704"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG5092879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="784" mass="91190" checksum="A9C852698B0ABFB1" modified="2022-05-25" version="1">MPGKGNKLTKIGKDIFKLEADNPKRKCLQRLDFSQFCFDESEERAAAIDLTGYFHFLLLINNDWIVKKFSNVGQSTFVAFNPIDQCEVIIGLASTDLKIVKLKQVFNDAESIEDFYELKGHQLPPTRISFFKSYCFSVSRSEAIIWDLKSFAKLHQLRLEPGEGGIRKGLLSPTGLITAIYENDTLQVWPFEQFDLVNKISLSEYGLNNTKDIIFTENGRAALICGGKNKIIIFNTKTWSVIKNFEFSEHFSGIKRLQIVPLPLDAGSNKIISVLFDDGTFKFFDINLKSFIEVTDHVAQGVRKLSVSPHGQWVGFIQYDGSLVISCFDQLMKLTAEVTKIKPTVNSASLKVKTHTIDQHLKHVERNIKDNLRLERLLPILKEYGEYPERYRPIIWRTILKLPSNKKAFIGIISKVPTDSTIKMLDDYKLADRTKTSVLALTVDRLVQFCPMFSQSLFIPEFIFPFIIVFKKDHLLAYEAVLTIILNYCQKWFEYHPFPPLNILGIIENILAETDPVLLKFYYDRDITSTTYAWPLLQTAMSEVLTGNEWLILWDHLLSFRKPTLLLICVVAYNICSRRTILSFMKKERIEEFFRQPGKISVKDVIKVALRIDGEISDRNHPAQYLKDTFCKLPPDGPYPTFLCEEYPKFIVEDREKMNELINLKDEEFNLRKKRQQISEIAEQKRLNDEKESFIKQIQEQRLREQRRCYDEQFRVSEAFVANERQKLYRQMLLSGSTDVTRVHSVSNKSSSRSKIKSYHELKDDVDTLEEEIRQFLRIIKRKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HBE7</accession>
    <name>A0A8J2HBE7_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS6431</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5092909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HBE7"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5092909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="92" mass="11258" checksum="8C4C8D0A9742B183" modified="2022-05-25" version="1">METKLMRQKSSELWSVEMCRHTYNTYIYMYIYLFGKFSHVIFCSEAKRRPVITCDLRHFLLYCARYVIYYYTFSLLVKILHPPFGHYCMGIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HBU8</accession>
    <name>A0A8J2HBU8_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Similar to Kcnj4: Inward rectifier potassium channel 4 (Mus musculus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">HICCMSTLAB_LOCUS6577</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>K(+)(in) = K(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29463"/>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Membrane</location>
            <topology evidence="1 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5093088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HBU8"/>
    <dbReference type="OrthoDB" id="273257at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034702">
        <property type="term" value="C:monoatomic ion channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005242">
        <property type="term" value="F:inward rectifier potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990573">
        <property type="term" value="P:potassium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034765">
        <property type="term" value="P:regulation of monoatomic ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1400:FF:000001">
        <property type="entry name" value="G protein-activated inward rectifier potassium channel 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000078">
        <property type="entry name" value="Putative Inward rectifier potassium channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1400">
        <property type="entry name" value="G protein-activated inward rectifier potassium channel 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041647">
        <property type="entry name" value="IRK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016449">
        <property type="entry name" value="K_chnl_inward-rec_Kir"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013518">
        <property type="entry name" value="K_chnl_inward-rec_Kir_cyto"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040445">
        <property type="entry name" value="Kir_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11767">
        <property type="entry name" value="INWARD RECTIFIER POTASSIUM CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11767:SF113">
        <property type="entry name" value="INWARDLY RECTIFYING POTASSIUM CHANNEL 2, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01007">
        <property type="entry name" value="IRK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17655">
        <property type="entry name" value="IRK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005465">
        <property type="entry name" value="GIRK_kir"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01320">
        <property type="entry name" value="KIRCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 12 17" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8 12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 12" id="KW-0630">Potassium</keyword>
    <keyword evidence="3 12" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 12" id="KW-0813">Transport</keyword>
    <keyword evidence="5 12" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="128"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="172"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="210"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel inwardly rectifying transmembrane" evidence="15">
        <location>
            <begin position="93"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="domain" description="Inward rectifier potassium channel C-terminal" evidence="16">
        <location>
            <begin position="246"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="17">
        <location>
            <position position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00034430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF01007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF17655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CAG5093088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="430" mass="49571" checksum="96F33B24FEE430D8" modified="2022-05-25" version="1" fragment="single">MEEPQKLFRLPGNIEEEEECENDNNSKQNNNPSRAESPLLSQKSHNASLIVPRNVTLVRENTQNSSIGNMGRQDSNRSRYRAGPIRRSRRRAVFKNGDCNVLQSRISRRSLRFLQDIFTTLVDTQWRWTLLCFTLSFVLSWLGFAVIWWLIAFTHGDFDINHLPPFQAKNNWTPCIYNIFSFTSCFLFSVETQHTIGYGSRSTTEECPEAIFVMCIQSIAGVMIQSFMVGIVFAKMSRPKQRTQTLLFSRNAVICQRDGELCFMFRVADMRKSHIIGAMVRAQVIRSITTKEGEILTLNQKELTVGTDDNNNGNIFFIWPMTIIHKINAESPFYDMSAEDMLTERFEVVVILEGTIESTGQTTQARSSYLPHEILWGHRFEPMVDYSKERQGYEVDHSLFNSTTQVDTPLCSGRELTDFYKVQDDSRYST</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HC19</accession>
    <name>A0A8J2HC19_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Similar to sn: Protein singed (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HICCMSTLAB_LOCUS6373</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the fascin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5092793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HC19"/>
    <dbReference type="OrthoDB" id="10259868at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015629">
        <property type="term" value="C:actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051017">
        <property type="term" value="P:actin filament bundle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007163">
        <property type="term" value="P:establishment or maintenance of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23351">
        <property type="entry name" value="beta-trefoil_singed_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.80.10.50:FF:000008">
        <property type="entry name" value="Fascin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.80.10.50:FF:000010">
        <property type="entry name" value="Fascin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.80.10.50:FF:000015">
        <property type="entry name" value="Fascin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.80.10.50:FF:000064">
        <property type="entry name" value="Fascin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008999">
        <property type="entry name" value="Actin-crosslinking"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010431">
        <property type="entry name" value="Fascin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022768">
        <property type="entry name" value="Fascin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024703">
        <property type="entry name" value="Fascin_metazoans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10551">
        <property type="entry name" value="FASCIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10551:SF9">
        <property type="entry name" value="FASCIN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06268">
        <property type="entry name" value="Fascin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005682">
        <property type="entry name" value="Fascin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50405">
        <property type="entry name" value="Actin-crosslinking proteins"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fascin-like" evidence="6">
        <location>
            <begin position="29"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="Fascin-like" evidence="6">
        <location>
            <begin position="148"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="Fascin-like" evidence="6">
        <location>
            <begin position="289"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="domain" description="Fascin-like" evidence="6">
        <location>
            <begin position="430"/>
            <end position="520"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF06268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAG5092793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="521" mass="57800" checksum="B3BD1C503428A452" modified="2022-05-25" version="1">MQSNGAESGSENGVDRTGWTVGLINGKFKYLTAETFGFKINANGSSLKKKQLWTLEGSEHQVFLRSHLDRYLAVDQFGNVTCEAEDTSDPGCAFQIQLASDGSGRWALKNIQRGYFLGSSLDELKCQAKAPGEAEYWLVHLAARPQVNLRSAGRKRFAHLSASQDEIHVDAPVPWGEDTLFTLEFRPAANPDNDVVGRGKSEGGHYALHTCNNKYLARDGKLLDTCTRDCLYAAEFHAGLLALRDINGAYLAPIGSKAVLKSRSTTVTRDELFSLEESLPQASFVAALNQRYVSVKQGVDVTANQDEISGHETFQLEFDRVTKRWYVRTMQDRYWTLEAGGGIQASDHKRSSNALFDLVWQDDGTVALRANNGKFLATKRSGHLYANSDSPDGSDSDASKYYFYLMNRPILVLRCEQGFVGPKSAASPKLECNKAGYETIRVERCERGIVRFKGQNGKYWHADSEGVTVDADQPSEGFHLELREPSRLCIKCTDGRYLAAGKNGALRLGETDHKSATKWEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HD23</accession>
    <name>A0A8J2HD23_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">60S ribosomal protein L18a</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HICCMSTLAB_LOCUS7195</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eL20 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5093869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HD23"/>
    <dbReference type="OrthoDB" id="1294322at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.10:FF:000001">
        <property type="entry name" value="60S ribosomal protein L18a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.10:FF:000002">
        <property type="entry name" value="60S ribosomal protein L18a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00273">
        <property type="entry name" value="Ribosomal_eL20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028877">
        <property type="entry name" value="Ribosomal_eL20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023573">
        <property type="entry name" value="Ribosomal_eL20_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021138">
        <property type="entry name" value="Ribosomal_eL20_eukaryotes"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10052">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L18A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01775">
        <property type="entry name" value="Ribosomal_L18A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002190">
        <property type="entry name" value="Ribosomal_L18a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160374">
        <property type="entry name" value="RplX-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein eL20" evidence="5">
        <location>
            <begin position="8"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR002190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAG5093869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="177" mass="20986" checksum="51AEE6A21584D07F" modified="2022-05-25" version="1">MKAKGELVEYEVIGRKLPTEKEKTTPLYKMRIFAPDAIVAKSRFWYFLRQLKKFKKSTGEIVSLKQIPESTPTKIKNFGIWLRYDSRSGTHNMYREYRDMSVSGAVTQCYRDMGARHRARAHSIQIIKVEIVKAANCRRPQVKQFHDSKIRFPLPKRIHHKNRMPLFSVRKPRTFFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HDH4</accession>
    <name>A0A8J2HDH4_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Similar to ema: Protein CLEC16A homolog (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HICCMSTLAB_LOCUS7238</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CLEC16A/gop-1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5093912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HDH4"/>
    <dbReference type="OrthoDB" id="294052at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016197">
        <property type="term" value="P:endosomal transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901096">
        <property type="term" value="P:regulation of autophagosome maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007034">
        <property type="term" value="P:vacuolar transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039272">
        <property type="entry name" value="CLEC16A/TT9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045820">
        <property type="entry name" value="CLEC16A/TT9_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019155">
        <property type="entry name" value="CLEC16A/TT9_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21481">
        <property type="entry name" value="PROTEIN CLEC16A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21481:SF0">
        <property type="entry name" value="PROTEIN CLEC16A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19439">
        <property type="entry name" value="CLEC16A_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09758">
        <property type="entry name" value="FPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0072">Autophagy</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FPL" evidence="4">
        <location>
            <begin position="49"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="CLEC16A/TT9 C-terminal" evidence="5">
        <location>
            <begin position="247"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="domain" description="CLEC16A/TT9 C-terminal" evidence="5">
        <location>
            <begin position="433"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="393"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="845"/>
            <end position="957"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="393"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="848"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="861"/>
            <end position="870"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="871"/>
            <end position="895"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="898"/>
            <end position="908"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="935"/>
            <end position="945"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF09758"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF19439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAG5093912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="957" mass="108510" checksum="93E41F56B804348D" modified="2022-05-25" version="1">MFRSRSWFGGGLWKPKNPHSLEHLKYLYNVLSKNQTVSDNNRGLLVETLRCIAEILIWGDQNDSSVFDFFLEKNMLSFFLRIMKQKCGSYVCVQLLQTLNILFENIRNETSLYYLLSNNHVNSIIVHKFDFSDEEVMAYYISFLKTLSLKLNAHTIHFFYNEVNKHTNDFPLYTEAIKFFNHSEGMVRIAVRTLTLNVYRVEDASMLAFIRDRTAAPYFSNLVWFIGNHIIELDTCVRNDADHQSQNRLADLVAEHLDHLHYLNDILCLNIEDLNAVLSEHLLHKLLVPLYVYSLTKSKNLSSHSTQEERKHVSVVVSLFLLSQVFLIVSHGPLVCTLASVILKSDSVIIENGASRMLEEYDLKTDKSIAFAPPIESLEKSLESLSGISEAQSPTIDVVSSNDSPPLSCTSEELPESSDSDIVKLDNLDDKIKHLNVTDEEKERLALESPVSSKIPEGLSNGPVVSRPFLDTILSSLQCTENDYAALFGLCLLYALISNESVNDETLDFLLSRRQKEMSNSWYNETLVEKLINVISMSCQNNAKIRLVTLELCVKLLLKIVMSDGQSLLCDAHLAAIESAREQSTALLRNFYKSEDIFLDMFEDEYVEVQKKPLNVEWLMMDSNILLPPTGTPMTGIEFTKRLPCGEVERARRAIRVFFIIRELSLTLNKETETQLPLTNPANCVQVNNVLDLSKSYSHNSDLIACTVVWKDGQKIRRFLVIDVIQLILVEPDTRKLGWGVAKLVGFLQDIEVAGDKDDSRCLHLTIHKPSSSSTNKLPLLSAKFIFDDHIRSRLLDIPTNLPSCSTPPNYALFGIRNERMAGRGQRPKDQPRPMFMVNKVPGFAAQMRKETPRARREDASPSGRSQDSSLRSRDSSPKMPRPRSEEIPLEDMRLRKSSLTVNGSASSSDRDEIPVLNLSINSESAVMNKHSEETSFTSPQSQQIKKSRRKGQVETV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HDL7</accession>
    <name>A0A8J2HDL7_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS5631</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5090441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HDL7"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5090441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="165" mass="18757" checksum="21D25EE0184A815E" modified="2022-05-25" version="1">MARKQIRKNAEAWMEILRCKDRIKSLENQIQILEGVVSPLRPATAERKSEQPVAINLDSLYDAVEEENEVAVKLNSTPKEATKTKKRKEKGDNNEAETIHQNESQKKKKKKKPPDQKSSNQQMENDSIIQFLDSPTHFGGTDSTSYGSTQGNLIFYLLLNIVELD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HDV1</accession>
    <name>A0A8J2HDV1_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Similar to ZBTB49: Zinc finger and BTB domain-containing protein 49 (Homo sapiens)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HICCMSTLAB_LOCUS5545</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5090231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HDV1"/>
    <dbReference type="OrthoDB" id="3176202at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24408:SF58">
        <property type="entry name" value="TRANSCRIPTION FACTOR (TFIIIA), PUTATIVE (AFU_ORTHOLOGUE AFUA_1G05150)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24408">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="405"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="433"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="493"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="521"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="551"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="138"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="138"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG5090231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="587" mass="66916" checksum="8C03DA5C1FE40DC5" modified="2022-05-25" version="1">MKELNTVEQNNNDIEVYSNGTTESTPDKKIKEEVTKNLIDEKNVVLNDNYNSIIKEGIYLIKEQVKLYNATMQYLLKTINLIADKKIPQKIISDYSSIVTSHNLLLDKDKINSEITLKIWNGSFVKSEESCNATIVENKKAEENVEDSTKDQSDKSPKIDKNSAQVDDDIEILNKSISSMDLNSSDELMNVMDVDLDPKQADSTLYSSLTSSSSPSTVILKKNTYPVNIDTLSNPVVLDNKTSKEIPLEVSNNSEEPNKKLSLIEVLKNANKSYSNMNRASQRLKRKAVDEEISLENNKKCFTADGNNDDKDNSSSQRRIIHSTKRKVLNAKIYSKKQEFKVPESFLPVVRLQRIKLPINEKNLSAMKTKVRKLETEKKDNVYNLRPSSRKNNCTEIKKINNIKVNCELCDKTFKTKECLKAHAQSQHVKKNFKCKKCNYASNFQGNLRRHIKIHQDTAVVSQSNLKTCLRSYAAKLHQRDSCSEVNRSKSSFKCSICLYTTKSLELLNEHTKSHNNNKLFNCNDCDKTFGRKKLLQEHRATSHASQSSRYSCNECQLTFSYYGRLSRHLRTVHGVVAGAINSKNNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HFZ6</accession>
    <name>A0A8J2HFZ6_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS6692</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5093251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HFZ6"/>
    <dbReference type="OrthoDB" id="6731322at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="292"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="438"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="161"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="181"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="198"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="313"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="376"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="445"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="490"/>
            <end position="499"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5093251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="645" mass="72464" checksum="0C5AC0BA5B738B10" modified="2022-05-25" version="1">MNLPDGVLGGEAVVKVEDGATVTERQAKWRSKLSRYKFNVVVRHKITEQYAEGLSYNPEGRPEPSENEINNKTVNNPLALPISAKPRPKGSHRKLSDSEAIEAVKRPGHPLGSKNKPRVSSAPEARDTIASRLRKREMGKTRVPPKINYHETSNFDITSEDPEKTQETGNEKQGDDEVFLPVSTPGPSTSNPTPDISQEGDDESEKEDEAEKDNETIVPQKQRRKTRELVKMFDELLQRRPPAENIYTERALERIHREEAISNYTPQEYAEIKRTSSDTAKNIRQSLNKLPPLWRSEDDSLNEDTTPEINVDEFLRENSDKSEEGSSDISPEETGGVEDLSEVEHPIIIEPRPPTSADDINTRNVIYTDDEENESNKNTLTPRNVNRSQFTGYLGDGPEPRTPIFGRVLIPDELAAMGIRYDHASRQIVDQNGKGINETAETESADPNKTPIESEQGQSNEKSSNITRLTNTQNNNKNKSRNSSEKSNDRPTISGNITVGNDIGNRRFGPPFVAYDPPTFEEAEDIFAERHHRPRISSPSSSDESIPPKGSKIKIKFSISRDGLTYARDHLVHFLAADCEIIKPVAKLLRDLKFINADDLHASKPTKGDVFVTKLGRCKIFTVFIKTKHFEKLDPIDLIEGLRNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HG53</accession>
    <name>A0A8J2HG53_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Similar to ZNF470: Zinc finger protein 470 (Homo sapiens)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">HICCMSTLAB_LOCUS8843</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5097719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HG53"/>
    <dbReference type="OrthoDB" id="7685779at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001370">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002343">
        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000624">
        <property type="entry name" value="zinc finger protein 697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235">
        <property type="entry name" value="KRUEPPEL-LIKE TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235:SF142">
        <property type="entry name" value="ZINC FINGER PROTEIN 384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="10"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="172"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="201"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="229"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="257"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="285"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="314"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="340"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="368"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="396"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="425"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="64"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="66"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CAG5097719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="561" mass="64588" checksum="180D86A68F2CF6AB" modified="2022-05-25" version="1">MTNTQENGMQVSGEVQEEVELTELLPVEQSRIAKDFKDLEGTDGLKALRSFAGSEFEGFKVFRKGKGSDKSEGLEIGDQEGKKNYNLRKKRKLDYLKDEVYYYQQDSEEESDDSSNQNVSNNVIKDMANNFSGKGEKRKKVKAEVAKKKEKILENNNESEASKSEDKSEKKYCCLMCDAKFKGSGGLRNHWKVVHADGPFYKCDDCGKEFPLKERLKLHVRTHTGFKPYKCSECDKSFARGGQLAQHRRTHSHAKPYHCSLCSGTFTCAANLALHMKRHNGQKDHKCDICGRGFIRRDALKKHLECLHKDVKSFLCVICNKTFKGHLPQHMRTHCQERPHGCATCGQRFAQKSQLTVHQRTHSGQRPFRCLVCWQAFAHSTALKLHTRRHTGERPFKCTECNVGFTQLPHWKKHMKCIHKRLEPYSCKNCNSFFRIKNDLESHEKMCLAEEDLEPAADDNQRFRLMSIEKMRLLLAVLLKRISKPEKLDELGFGKRLIDEVLQDSLVSAGRDPVGGDLTELEALRKNIETFLEWTVPREHWENFKKLNKTPEEILETLTAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HGE6</accession>
    <name>A0A8J2HGE6_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to Ttpa: Alpha-tocopherol transfer protein (Mus musculus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS8186</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5096391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HGE6"/>
    <dbReference type="OrthoDB" id="75724at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902936">
        <property type="term" value="F:phosphatidylinositol bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1200">
        <property type="entry name" value="Alpha-tocopherol transfer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.20">
        <property type="entry name" value="N-terminal domain of phosphatidylinositol transfer protein sec14p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011074">
        <property type="entry name" value="CRAL/TRIO_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036273">
        <property type="entry name" value="CRAL/TRIO_N_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10174">
        <property type="entry name" value="ALPHA-TOCOPHEROL TRANSFER PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10174:SF220">
        <property type="entry name" value="LD41874P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00650">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00180">
        <property type="entry name" value="CRETINALDHBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM01100">
        <property type="entry name" value="CRAL_TRIO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00516">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46938">
        <property type="entry name" value="CRAL/TRIO N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="380"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="domain" description="CRAL-TRIO" evidence="2">
        <location>
            <begin position="179"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5096391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="515" mass="59866" checksum="39EEF7708C4617EB" modified="2022-05-25" version="1">MLLKFGINGSFFVVIILLTYSSSHKWFDFCAWFSIVNIKLKITKSGNVEISRFIIFSKMDVITPQSLGTYEAFYEKSKRIQPLKVGPYIFRLELDPPNNELLEKAKNELNESIHTVNKGLAEIRELLQGEPELNVPDDDYFLTKFLRPFKWHAKSAFEMIKHLYHYHQKYPVYNDDLTPMNDRDVLTSGVVAPLPVRTSDGCRLFLLQGGTRWDPSKISLTQILRGMKLLSECAVFEPTTQICGVRILFDLGGLTLSHAICFTPSYAKAVLEWVQKCFPGRVKSIHFINNPFLFNMVFALFKPFLTEKLRKRIHFHGADKESLLKLVDRKAVPKYMGGDLDVPIQPLGKPVWEYYCNFQEEFEGSETWVSEEKVTFSSSYLIFIYSCGISTILIFAYFSLNILYSFISFQYYITIISNTSKIDFTQHKHSLIKKSLCLHIPSCYKTNFQRAINTFEIILYDKNLQITYNFLKLNSSDTKFKTLFFEINIFVLLDRTNSYCIKNSLWSVEYIFDLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HHM1</accession>
    <name>A0A8J2HHM1_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Similar to Nfat5: Nuclear factor of activated T-cells 5 (Rattus norvegicus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HICCMSTLAB_LOCUS7890</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5095802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HHM1"/>
    <dbReference type="OrthoDB" id="5346094at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048468">
        <property type="term" value="P:cell development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048731">
        <property type="term" value="P:system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.340:FF:000002">
        <property type="entry name" value="Nuclear factor of activated T-cells 5, tonicity-responsive"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.340">
        <property type="entry name" value="Rel homology domain (RHD), DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002909">
        <property type="entry name" value="IPT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008366">
        <property type="entry name" value="NFAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008967">
        <property type="entry name" value="p53-like_TF_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032397">
        <property type="entry name" value="RHD_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011539">
        <property type="entry name" value="RHD_DNA_bind_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037059">
        <property type="entry name" value="RHD_DNA_bind_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12533">
        <property type="entry name" value="NFAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12533:SF7">
        <property type="entry name" value="NFAT NUCLEAR FACTOR, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16179">
        <property type="entry name" value="RHD_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00554">
        <property type="entry name" value="RHD_DNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00429">
        <property type="entry name" value="IPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49417">
        <property type="entry name" value="p53-like transcription factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50254">
        <property type="entry name" value="REL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="RHD" evidence="10">
        <location>
            <begin position="257"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="77"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="147"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="203"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="520"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="575"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="671"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1055"/>
            <end position="1097"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="80"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="148"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="209"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="229"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="536"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="671"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="684"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="703"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1071"/>
            <end position="1097"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAG5095802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="1143" mass="123120" checksum="00AEF32D9A256C7E" modified="2022-05-25" version="1">MAPDFEKKRQPAKVTGYFGHCSYNNNKQGMILLKCPGNPFTDYYHHGNTVSESGTSTVTSLSTRSLASNTLRQSSRRFNQPSAQQQLPQTQQQQQQPQRRSPARIPLASLSSVTVRNSDELVAANLTTQEVCDSSNDSGLGFEERQQHLGNSSTWNNGAAGEEDSKRRKMDIKLESEDANFTFPEVSRNTTGVAGAAPRVTVSDDSKISTRNTTTSTTSSSTANGVTQSRNANNSVNRVVGVTRPRSTLGGYGKRLPPQQHRARYQTEGSRGAVKDRTGNGFPIVRLVGYDKPALLQVFIGTDLGRVAPHMFYQACRVSGKNSTPCIERKVDGTIVIEVDMDPSKDMLVTCDCVGILKERNVDVEHRFPQAAGMLQGRSKKKSTRCRMVFRTSITLPDGTTETLQVCSQPIVCTQPPGIPEICKKSLTSCPCTGGLELFILGKNLLKDTRILFQLDDEDLSNMEQHWECSVIPDKEFLQQTHLVCVVPPYARQDLRPTETVTVKLYAVSSGKTSEPHTFLYTAASSPPEPSVGKVESSSPPLVTSRNEPLSTSPTIPIGAVNNNSLISQSSAVSPNFLTNLPQSTSQQHSPQPPSDSLKNDPSPPPVSSSAQVTPVMMWATQQTGNCQNSSADVMMPPPNLVASSLLNRRSSSNHQLIIPDSLKSEVIDENSGNSMLSDNSLQSMPTPNSNSTASTSPIHQYVSENSRDSTSTGLLRSVPSHVTPSQETVSLLGVVDLMRNQHPLTLITQHQSPYTGIHEQSGVKVLNTHHISKDTSPILQNESTGSGTLSGVGVGVDLRMKHHEYETLSNFTTTPAAQPLPNQSSQSIEKYFNHIESTAPTVKESDQEDSNFVDTMQQHSVLVGPRPQDQSSPTDILAPNAATVKLDALVNSAVESHQMDRMVAPLQTVTTSPGLLSHVPEVDAMSTSQTTTRTSPPIPVKAMLLEALMPSPVVPATGATNGSNGTVISAPLPEESLMTTINAALLPSIQEPIRLTNAAEQAITNVITNATQDIINNRPISTTTAHAIIATKNILNSVATQSAQLMNTAMEGILPKSPSNAGTVAEQVSRKSSPNSLPVAQNRSNNTNGMSNAVNNSNGQVSVVRKAEDAGGMLPQELTSMSEHDLLSYINPSCFDQGAFLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HHV0</accession>
    <name>A0A8J2HHV0_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similar to jockey\pol: RNA-directed DNA polymerase from mobile element jockey (Drosophila funebris)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS9755</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5100682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HHV0"/>
    <dbReference type="OrthoDB" id="7700723at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47027">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47027:SF20">
        <property type="entry name" value="REVERSE TRANSCRIPTASE-LIKE PROTEIN WITH RNA-DIRECTED DNA POLYMERASE DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="110"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5100682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="611" mass="69235" checksum="B0A45744015767C1" modified="2022-05-25" version="1">MDNSIFLPKFFTNYKLNILVHRLSGFTAWDVQVVVLLLVIKTISTARFLIHLPGGFSPDFLLPTRIFDLSPHLDLLQDVISDIQHKYPAAALFIGGDFDARVGEADYIQEKALTGTVLTSLRTSSDRVLNSRGSQIFDFFQTSGFILLNGRTTGDVPAQFTYCSARGKSNRLTIWINETKALPEEQAGFIAKRSCDDNIFTLLATIQLNLCNRKSQLHGLFVDFRRAFDSVPYDLLWKKLFNLGVSPKLIKILRNLYNLAKFQVKSGHHLSNKFDITEGVLQGEILSPTLFILYLHDIVDFFRARRVVGTRIDCSHDLLMLLYADDLIILASSVGDLRKKLVILEDYCRINALTVNIQKTKAMNFRKGGPGEKTKLHLNGELIEWTDHYMYLGLPFTTSSLGLLASKNASQRAKTAVGAAISTLAAIKADSWESMLKIFDSIVASTLLYASHIWGLRYLNHIEITQFSFFKRLLFLPLGTPSADLKLELRIRNVKVQVLKMALSWVCKVLDMPNHRLPKICLLQLIKLAKNRDTNLKYNWVLQLKEVLDAFKAPTTLWDNLSSSFWRRHINSILSSYSDHLTSVDLDKVNSSRSCQIHIPRSLNSDTANYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HHW6</accession>
    <name>A0A8J2HHW6_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6570 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS8071</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5096161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HHW6"/>
    <dbReference type="OrthoDB" id="7699899at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046700">
        <property type="entry name" value="DUF6570"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20209">
        <property type="entry name" value="DUF6570"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6570" evidence="2">
        <location>
            <begin position="298"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="601"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5096161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="601" mass="69743" checksum="815679CB80AEEC04" modified="2022-05-25" version="1" fragment="single">MEVTYSSENDPGVAEHVDAVINPETCPSTTTGHKKTQAIRQQEYRLRMKEKSGPKKQKEDRPAKKSAAERQRECRLRKKLRANQNINAESNSDVTEILPRQDAGPSNYLTSVTTAQVVPSSPDDGPVITHHEVVIETAPVSTIKRQNVQQHESVSDVYKKRKPNQTRNLNFDEICQLPSQPILTPRLLTNEMEILQPAENEFIENEDNINMSEESTSEPNSSLPYRSYQTHKSAHKLFKKKILENSFGHACNVCDRLWFLEDLKCGSADEEILLKRITNFTDVTQVMMCKTCRASILKGNIPFLATYNGFKYPQRPVDLPELDIIAERFISPRLPFMQIRRLRHFNGQFAITGQIINVPVSVDNMIKLLPRPLDGNEEDYCINVHIKKKLIHKTSYLHGLVKGIVIKKWLTYLIETPLYKHFQIKVDDAWFTSNERKVPKVIRFRNYDMGKELTEYKREMVTLHMPFRIEETDVLSDMKFLRIYDENEDLIMERRKEFESNLDIAKTMEICAQLCREETELNDVQANNDDQNRANVQEILDPYQQFLQDPNSAINDDLVSASMNKLGAIWKKKDNLMETPEFLELMRRTNEKQFELAQHII</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HIE3</accession>
    <name>A0A8J2HIE3_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS8324</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5096666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HIE3"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5096666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="61" mass="7093" checksum="31EBE8B6E859B789" modified="2022-05-25" version="1">MGNPSSPISANIVMNHILTRIIEILPFPVPVLTRDKNIQDYRLKIKKFLRFPLYQLSIKSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HJG9</accession>
    <name>A0A8J2HJG9_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">NTF2-related export protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HICCMSTLAB_LOCUS11444</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Has a role in nuclear-cytoplasmic transport of proteins and mRNAs.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5103307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HJG9"/>
    <dbReference type="OrthoDB" id="25408at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006913">
        <property type="term" value="P:nucleocytoplasmic transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00780">
        <property type="entry name" value="NTF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.450.50:FF:000006">
        <property type="entry name" value="NTF2-related export protein 2 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045875">
        <property type="entry name" value="NTF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002075">
        <property type="entry name" value="NTF2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018222">
        <property type="entry name" value="Nuclear_transport_factor_2_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12612">
        <property type="entry name" value="NUCLEAR TRANSPORT FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02136">
        <property type="entry name" value="NTF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50177">
        <property type="entry name" value="NTF2_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2 5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="NTF2" evidence="6">
        <location>
            <begin position="15"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00070836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU369002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAG5103307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="140" mass="15964" checksum="9C3998453A720475" modified="2022-05-25" version="1">MEQDLKSKIDEACRTAEQFTKLYYESLDKRRYHIARLYLDTAQLIWNGNGVEGKDEIQKFWINLPVSNHNITSLDAQPVTSPAVEEQLTFLVKVGGQVKYSDKASKPFNQVFLVTATGDKWKIVSDCFRTQESLENVTGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HK47</accession>
    <name>A0A8J2HK47_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS10569</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5101667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HK47"/>
    <dbReference type="OrthoDB" id="420032at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048788">
        <property type="term" value="C:cytoskeleton of presynaptic active zone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042734">
        <property type="term" value="C:presynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044325">
        <property type="term" value="F:transmembrane transporter binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048791">
        <property type="term" value="P:calcium ion-regulated exocytosis of neurotransmitter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050806">
        <property type="term" value="P:positive regulation of synaptic transmission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042391">
        <property type="term" value="P:regulation of membrane potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048167">
        <property type="term" value="P:regulation of synaptic plasticity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039032">
        <property type="entry name" value="Rim-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12157:SF21">
        <property type="entry name" value="RAB3 INTERACTING MOLECULE, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12157">
        <property type="entry name" value="REGULATING SYNAPTIC MEMBRANE EXOCYTOSIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="173"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="189"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="211"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5101667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="283" mass="32083" checksum="965D2ACBF0AB87F9" modified="2022-05-25" version="1" fragment="single">VIWVCIVCRKKQELLSKTGQWMVKTGLGAADQAMMRRMQEDLQNEGPPGRTELTQDKRPKLERAHSAAEKENLPLLQRSGSALRRQYSQQEQIPNRRLSTSDSGVEMSVSPHSRSLPTPHVVVGSYPQQTPRHPAAFPEDDPNIYRGELDGLMKQHAQMYQRSRQIYQEQNSNMPMTYGHSGVDNSRVHQSQQHQIHQVQGKHLSQAIPPTGQNTGQLHQQRSFSSSEEERSTPECASDEPDESEKGEKRAPIVASPRSPRSKAGDRIYRQAMLDEKMKKFLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HL84</accession>
    <name>A0A8J2HL84_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Similar to Lpgat1: Acyl-CoA:lysophosphatidylglycerol acyltransferase 1 (Mus musculus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HICCMSTLAB_LOCUS10863</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5102134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HL84"/>
    <dbReference type="OrthoDB" id="5920068at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036149">
        <property type="term" value="P:phosphatidylinositol acyl-chain remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07990">
        <property type="entry name" value="LPLAT_LCLAT1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032098">
        <property type="entry name" value="Acyltransf_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10983">
        <property type="entry name" value="1-ACYLGLYCEROL-3-PHOSPHATE ACYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10983:SF2">
        <property type="entry name" value="ACYL-COA:LYSOPHOSPHATIDYLGLYCEROL ACYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16076">
        <property type="entry name" value="Acyltransf_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69593">
        <property type="entry name" value="Glycerol-3-phosphate (1)-acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="90"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="372"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="domain" description="Phospholipid/glycerol acyltransferase" evidence="5">
        <location>
            <begin position="124"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAG5102134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="400" mass="46350" checksum="DDC355E053490909" modified="2022-05-25" version="1">MVDINCARESYSILYDGWHFSKMTDSSSSPSSAFINIITNIFTVVKAVLRIGFVILNNIYCIPTYVIWMMLLSPVKLFQPGIYWRIEGLFFHWLLAMVSMWSWSAGYDIIEHGDDLQPIINDRTLVIANHQSTGDVPMLMAVFNSKPNVLPNLMWIMDRIFKFTNFGIVSLLHRDFFISSGRKRREESLKQLELHLDNSYIPLERKWIVLFPEGGFLCKRRETSQKYAKKNNLPILENVTLPRVGAMRTIFDKLGPVLNNDPSENQLNARSNVGLNKPEIRWVLDITVAYPQGKPIDLPTIITGSRPPCETVLFYRLFPSSVVPKDPDLLSKWLYDRWAEKETLLDNFYKYGSFVGSSDSSREGSKIQQDPLRYLVLHLFFITSSYIHYHMFSYVLSCIW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HLF8</accession>
    <name>A0A8J2HLF8_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">HEAT repeat-containing protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HICCMSTLAB_LOCUS11000</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Involved in nucleolar processing of pre-18S ribosomal RNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
            <location evidence="1 8">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the HEATR1/UTP10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5102408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="31183at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034455">
        <property type="term" value="C:t-UTP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045943">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012954">
        <property type="entry name" value="BP28_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021133">
        <property type="entry name" value="HEAT_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056473">
        <property type="entry name" value="HEAT_Utp10/HEAT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022125">
        <property type="entry name" value="U3snoRNP10_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040191">
        <property type="entry name" value="UTP10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13457">
        <property type="entry name" value="BAP28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13457:SF1">
        <property type="entry name" value="HEAT REPEAT-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08146">
        <property type="entry name" value="BP28CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23243">
        <property type="entry name" value="HEAT_HEATR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12397">
        <property type="entry name" value="U3snoRNP10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50077">
        <property type="entry name" value="HEAT_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 8" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="4 8" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="U3 small nucleolar RNA-associated protein 10 N-terminal" evidence="11">
        <location>
            <begin position="236"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="domain" description="Utp10/HEAT1 HEAT-repeats" evidence="12">
        <location>
            <begin position="1302"/>
            <end position="1512"/>
        </location>
    </feature>
    <feature type="domain" description="BP28 C-terminal" evidence="10">
        <location>
            <begin position="1783"/>
            <end position="1885"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="7">
        <location>
            <begin position="2052"/>
            <end position="2088"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1115"/>
            <end position="1134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU367065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF12397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF23243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAG5102408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="2090" mass="238522" checksum="72AE054BF1514E9E" modified="2022-05-25" version="1">MATSLAAQLKKLEVPQTSLLLQDKKRPSLLFDPKEAANLDLEKVFKIGKSGFDELLKQSAVFEQFESIFFSESSLKFERAVHSSMENEKLDAVINNFLIYLSPYFLLHTAHKTLEWLIRRFRIHEHNQDQFIMLILPYHDTRIFVRALQLVDLTKPTNKWHWLEPIQKPGVPLSSLAVVNRLACDNSFLNLLCSHVRNATEVYGVESHRLSTLYSFYATRVIGALERSEKITEVQVSHLLPVLLDGLRNSVVDFIASTYMVLTQLWTKARLDDKTIRFLLSKALKHPPNELRNEVLMLVYYVYDTPHHSFKAVSDKIVNRIVNKSWFCEETTKIRNTKIDTSKFLILLTESAIKIVVKDPTEAEEVQEFMINLFEKINFNDKEIDTILKTTLKPSLVSGKLSMAGKEFLSQLFKAIETRYPVRFDEYLKNLMEKSEKDLEAKSILQFLTSWHSGTRDTKKSMEILSRLFHYSADQRVLALNTLSTETLHISDGFQELLNNALLQRFNDEDVRVVKALLDFPVKRLQSLFSTEVLVDNLMILLSQCHTAKRHTLASPALKILLEVWDEGDDTSIFIATLPYLFPSCVEEITLALQILNSEFANKNKLLQKVKENLGPHILAKDPIVSGITAEEIGSTAFHNMINWELIPPTENILSTMKLSDNVDATAVFFNLMLLGSVVRVPVKKLPPKTALEVIEMVAKMIKQYPKVQVMPEYNQLNGQNIHEALKMTSKEILPLQAGTGVLEQVHRRFDLQSKLNLDFENDPENANLILRTLEILFDGMASSIHKAHYSWCVKLFFQRHFSSASDLLRFLSQFFVKPVAPQTSFHCLQIALAVLSHSKSFQWIHQDKTFIANLLIALSRPNPRCREAALTILKRITQTFNISMEGASVLLNQISNRESEILLDPEQLRVVLYLTLSPDPAIKSQFKENEWEKLQDTREFLFNIILDDSVPIHTSAQLLEVLIFVNGPKVLQELAPKGVRLLKQLKEFPDKFYTKLALSNILQRFESSTAEALKQEYTWKLFDQAIVTHRVEIPWKDKQKSPSIVILKQIDQSFYDKVSKVVPGLEKKIIGKLVDIVADCEVGSIVTAATRVVKRIQIDAQLIVDELRAMKEAKLPEEDTSQQTPAQRRRSQRMKRIHLRPEIINTREWRRGITVLEFIQRGDNQELNVNNQELLLPVLFELLRLCIAFEEQSPLEYTNQLLLSAINYLSSKGLPIPDPHQQVDLISQCIRISQNPGTHHHALLVLVELFKVADISTALHNIMPIFTFMGSSVLRQDDAYSIQIISKTIETVVPIINANNDETHACEILRIFVISLPDIPEHRRIPIFTKLLQLLDNHLHLFYLLTFESHVLIPGKDSQLQQTSSQRLEFALSISQEFPAKTLIDVCVKLVEFMKILPVEIKDNHRQHIVFTKNYIFDVSKNSPKQLRHYRYTIVQFLSALLSSQDFVDKVALLSDKDLSQIRPLCENLIVELIVIIQSASKSADSAQGKPTEKYWKVLLHNLYEILSAVNSLLPSEVFVMSVEKLINHDLLTVRRKILELLNARLQQRKFAEQNRTQLITLVKPLMEIVGKHGKMLSQEMEVVQQTALITLKLLAKLLAFEHPEEFTPVLILTTKYMSAKEGPLLGSVVLCVAELSSAMKIHAIPLLSKFMPGIIKLVKTHCHQESPDIVVVSIISALQKIVDSFARFLSSYLDELLLELCRLNILYTDPDHPKIGIVVAKLKATCQKISSDVRLSPLLRITGEVYDSVNKKGQNYALIPPLMAILSDAFAGLTRVTLKGVKSELTSFFLKFLQFREKIGTTDAMETDDEQNEIAKRIYMVEESVSKALIAWVLKFDVLTLKDFYRKELLPWTRGESELKCRKIIFYRLSSNVMDGINELSESSPESSSTALTELVSAVPNFMLPLAAPLLKDNNLKVNPLGDDTFKEEFSRVEVTEAILSTLKKIFKIVPSNAINLEWFDILIQPIVDQIENVMGSKEEFEVRAKELIVPCVAYFAAATPDAAVHKKIIYQTLLKTQHKESHVRSTALNAVVEIARKLQEDFMPFLPETVPFLAELLEDGEKQVEKATLEAVRTLEDILGEPLQKYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HM00</accession>
    <name>A0A8J2HM00_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">Very long-chain fatty acid transport protein</fullName>
            <ecNumber evidence="14">6.2.1.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Long-chain-fatty-acid--CoA ligase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="21">Very-long-chain acyl-CoA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">HICCMSTLAB_LOCUS8550</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="19">Acyl-CoA synthetase required for both the import of long chain fatty acids (LCFAs) (C14-C18) and the activation very long chain fatty acids (VLCFAs) (C20-C26) by esterification of the fatty acids into metabolically active CoA-thioesters for subsequent degradation or incorporation into phospholipids. The transport and fatty acyl-CoA synthetase activities are genetically separable and are thus independent activities. Esterifies VLCFAs in the peroxisome matrix. The VLCFAs are actively transported into peroxisomes by a PXA1-PXA2 heterodimeric transporter in the peroxisomal membrane.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>a very long-chain fatty acid + ATP + CoA = a very long-chain fatty acyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:54536"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:58950"/>
            <dbReference type="ChEBI" id="CHEBI:138261"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:54537"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>tetracosanoate + ATP + CoA = tetracosanoyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:33639"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:31014"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:65052"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="18">
            <dbReference type="Rhea" id="RHEA:33640"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="17">Peroxisome membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="24">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.3" evidence="14"/>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5097117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HM00"/>
    <dbReference type="OrthoDB" id="288590at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005324">
        <property type="term" value="F:long-chain fatty acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004467">
        <property type="term" value="F:long-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044539">
        <property type="term" value="P:long-chain fatty acid import into cell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.30:FF:000002">
        <property type="entry name" value="Long-chain fatty acid transport protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12780:FF:000019">
        <property type="entry name" value="Long-chain fatty acid transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006134">
        <property type="entry name" value="PRK08279.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43107:SF21">
        <property type="entry name" value="FATTY ACID TRANSPORT PROTEIN 1, ISOFORM F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43107">
        <property type="entry name" value="LONG-CHAIN FATTY ACID TRANSPORT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="11" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="22">
        <location>
            <begin position="88"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="23">
        <location>
            <begin position="526"/>
            <end position="601"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00026121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00036527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00041297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00046271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00048666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00060276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00068795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00078285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="CAG5097117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="648" mass="72642" checksum="165F881640E67D96" modified="2022-05-25" version="1">MDIRFACLVVTIAVLMAAGVVARIGSFTRITQIAVTALLIPLFYKYHRRIYVIIRTLPRDIKFLYRYLNADKETKRFVKNNTTVMEIFSERVKLYPNKPCFILEERTWTNAEINEYSNRIANTFIKHGYVKGDAVALMMTNRPEFIATWLGLGKIGVITALINTNLRLQLLSHCLTVAKVKGVIYAAEFSSAIDEINDSIEGIKKYKEGAGLNDAQQGTENLDKLMSEASSENPVVENEPGYRDNLLYIYTSGTTGLPKAVLMPNSRYLLVTMATYHMLGLRDGDIMYNPIPLYHMAGGLVGTGCALVKGIPSVLRTKFSVSHYWTDCIKYNCTLAQYIGEMCRYLLSAPARPEDSQHPVRLMVGNGMRSHIWQQFVDRFKIEQITEVYGSSEGNANIVNVDNQVGAVGFIPSILPKPLHPVAIIRINPETGEPVRGPNGFCIRAEINEPGMFIGLIKQGNASREFNGYLDEEASRRKVIENVFVKGDKAFLTGDILVQDELGYFYFKDRTGDTYRWKGENVATAEVEGVVSNVAGYRDTTVYGVQVPGMEGRAGMAAIVDPECLLDFKALAEGLDRALPSYARPIFLRIVNELEMTGTFKLKKINLQKEGFDPNKIQDKVYFRSGNKEYVEVTPELYQEIISGSTKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HM42</accession>
    <name>A0A8J2HM42_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS12440</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5106798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HM42"/>
    <dbReference type="OrthoDB" id="2095648at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00646">
        <property type="entry name" value="F-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="4"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5106798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="425" mass="49565" checksum="C8D46BBF09FFAC4F" modified="2022-05-25" version="1">MIFSDEVWLIILENLSIPELVKLRLVSHCFKELAEYVLKRHPGWEDLAKKNMQIEWLEDVMVKACPYDLISHQNEIHDPALWRKTYLSYINWQKILVKADVTFNKVPPSNFGYIVYTTTFDKYLLLVFGNNVIEIYTFVDDDPFRLLFKFQMNNYVPQAEFWQSNGDLLVVFQDRDSNLTFWDINKKIKITNNGCSSTRISRNGCRDFCIGENNGIITSFERDGNIISPGQSINLKLTEDQEVLIHTVHTNYLSILVYVHNAVILYNYKVMINNGMVAGFQFIDTTGPMRLIHPLNKWANFTILNTDYLYVTNDFNGFATNYHLEDHDLIHFYTPSRWGNVMSAAMHAHLVILGCQNGSIRLFSIEDTSEMMALYGDPANILYSRNIRTIKASNRPIFYLNFWEFEDKIFIVAVTDESIRLIKFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HM73</accession>
    <name>A0A8J2HM73_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Single domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HICCMSTLAB_LOCUS11472</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5103363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HM73"/>
    <dbReference type="OrthoDB" id="6761907at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029277">
        <property type="entry name" value="SVWC_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15430">
        <property type="entry name" value="SVWC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01318">
        <property type="entry name" value="SVWC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035315749" description="Single domain-containing protein" evidence="3">
        <location>
            <begin position="21"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="Single" evidence="4">
        <location>
            <begin position="33"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAG5103363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="98" mass="11105" checksum="F10DCBC1C6A3A835" modified="2022-05-25" version="1">MKAFFIVLCAFACLWIQANANCVSLNQKEEGEKIYKAGEKMIKQSECAEYTCHEDGSWTSLGCGVWQCEDAVGYQNYDYSKPYPECCPHPICKSDLKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HME0</accession>
    <name>A0A8J2HME0_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Similar to mettl23: Methyltransferase-like protein 23 (Xenopus laevis)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HICCMSTLAB_LOCUS10325</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the methyltransferase superfamily. METTL23 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5101252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HME0"/>
    <dbReference type="OrthoDB" id="407325at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019410">
        <property type="entry name" value="Methyltransf_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614">
        <property type="entry name" value="HEPATOCELLULAR CARCINOMA-ASSOCIATED ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614:SF164">
        <property type="entry name" value="HISTONE-ARGININE METHYLTRANSFERASE METTL23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10294">
        <property type="entry name" value="Methyltransf_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00043988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAG5101252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="227" mass="24926" checksum="9068C010C88D452C" modified="2022-05-25" version="1">MPGLEEESIWFETSPSASSLMSDGVAAEQVKKFFFTSRRSDETGQQDESLEIFIPENREAVVGKRILELGSGTALPGIVASKCGAHVTLSDAANLPKNLQHIRRSCELNGVLSQVKVVGITWGLFLSSLLSIGPLDIILGSDCFYEPTVFEDIVVTVAYLLERNPGAKFLCTYQERSSDWSIEHLLNKWGLTCNQISLIGLGADAGITLEELMQDHTIHLLDIRKSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HMH9</accession>
    <name>A0A8J2HMH9_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS13420</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5108784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HMH9"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5108784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="115" mass="13642" checksum="852010E311D55D6B" modified="2022-05-25" version="1">MMSAWPRIHCAIYTTRFFIYKFRQNKIEILFRNVFGILVSKFKHKLATEADERGVSPVEIVEIVSNYVDSCHGFTSRSFDRCIQRWTKLFKLFLERSEPLAIDLQRPVSPLWLVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HML8</accession>
    <name>A0A8J2HML8_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Similar to gsb: Protein gooseberry (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">HICCMSTLAB_LOCUS13496</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the paired homeobox family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5108860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HML8"/>
    <dbReference type="OrthoDB" id="3225452at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007365">
        <property type="term" value="P:periodic partitioning"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009791">
        <property type="term" value="P:post-embryonic development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00131">
        <property type="entry name" value="PAX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000679">
        <property type="entry name" value="Homeobox protein aristaless"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000003">
        <property type="entry name" value="Paired box protein Pax-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000031">
        <property type="entry name" value="Paired box protein Pax-7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043182">
        <property type="entry name" value="PAIRED_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001523">
        <property type="entry name" value="Paired_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043565">
        <property type="entry name" value="PAX_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45636">
        <property type="entry name" value="PAIRED BOX PROTEIN PAX-6-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45636:SF3">
        <property type="entry name" value="PROTEIN GOOSEBERRY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00292">
        <property type="entry name" value="PAX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00027">
        <property type="entry name" value="PAIREDBOX"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00351">
        <property type="entry name" value="PAX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00034">
        <property type="entry name" value="PAIRED_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51057">
        <property type="entry name" value="PAIRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="6 10 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7 10 11" id="KW-0371">Homeobox</keyword>
    <keyword evidence="9 10 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0563">Paired box</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Paired" evidence="14">
        <location>
            <begin position="19"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="Homeobox" evidence="13">
        <location>
            <begin position="186"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="10">
        <location>
            <begin position="188"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="138"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="138"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="152"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CAG5108860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="408" mass="44675" checksum="2692714F1BCB1079" modified="2022-05-25" version="1">MAVSTLNMTPYFTGYPFQGQGRVNQLGGVFINGRPLPNHIRLKIVEMAAAGVRPCVISRQLRVSHGCVSKILNRYQETGSIKPGVIGGSKPRVATPEVEAKIENLKREKPGIFTWEIRDHLIKQEGVCDKTSVPSVSSISRLLRGPTSQTRPGDDPRRNHSIDGILGGSSGDDSDIESEPGIALKRKQRRSRTTFTGEQLEQLEAAFHRTQYPDVYTREELAQKTKLTEARVQVWFSNRRARLRKQLNSQQLNAFNTMSLQSFQTQHGYPSGADSYQSYGQASVAAAAATTAGYPQHYNYGENYYGAAQQQWPRATPENYGLFNSSHYGSTNLTSNLSPSNLNLGGLGGNVSPTGSNMSACMVQGTTTTVSNGMGHHHHHVTPHSPSEAKSGYPYLGAIDSQVCGRIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HPD0</accession>
    <name>A0A8J2HPD0_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">EGF-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS11703</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5103825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5912242at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39069">
        <property type="entry name" value="ECDYSONE-INDUCIBLE GENE E1, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39069:SF8">
        <property type="entry name" value="FI17111P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="17"/>
    </dbReference>
    <dbReference type="SMART" id="SM00286">
        <property type="entry name" value="PTI"/>
        <property type="match status" value="10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EGF-like" evidence="1">
        <location>
            <begin position="167"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="1">
        <location>
            <begin position="312"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="1">
        <location>
            <begin position="346"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="1">
        <location>
            <begin position="429"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="1">
        <location>
            <begin position="469"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="1">
        <location>
            <begin position="560"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="1">
        <location>
            <begin position="678"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="1">
        <location>
            <begin position="753"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="1">
        <location>
            <begin position="836"/>
            <end position="870"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="1">
        <location>
            <begin position="924"/>
            <end position="958"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="1">
        <location>
            <begin position="998"/>
            <end position="1043"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="1">
        <location>
            <begin position="1093"/>
            <end position="1127"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="1">
        <location>
            <begin position="1310"/>
            <end position="1344"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="1">
        <location>
            <begin position="1413"/>
            <end position="1447"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="1">
        <location>
            <begin position="1487"/>
            <end position="1532"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="1">
        <location>
            <begin position="1539"/>
            <end position="1575"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="1">
        <location>
            <begin position="1581"/>
            <end position="1615"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5103825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="1675" mass="186744" checksum="E82B2FCCFFE72981" modified="2022-05-25" version="1">MFVDGFVISVLHKFCHSDEDCVNIKFTKCSSNKKCICESNYLASKDETSCLPLIGGECEVDDDCVTENSRCYFRRCQCNKYSVAKVIDQKYECKQTVVLGVPCGNHKDCALIQNSQCSDDKVCACRTNHYEFNNQTFCGPIINEEIQCSKQNYCVCKSNNRLINKATCYPFLNGLCWKDDQCLLPNSVCIDFHCQCQSSFKAVATNLCIPVPDISCITNTDCERQKFSECTAYGSCRCQSNYVKTNPSTCQGLIGAACSRNYECFPHDSICLDGFCKCKCNYLSTVSDLCLPNNFDFVLAFFELTCSAGDERCQDEEFSGCLHGKCHCHPNHVVGNMTCQPLLHENCAKNGQCAIKHSICRDNVCQCKSDYIALSNNRCLPTKLNGYCQINDDCRYLDNSKCSKYYYCTCIDNYFHFNETTCVPLIGEKCESNADCMIENSICFNGFCKCKNSYKSSFNEKCVTALHNFCKTDSDCHEGTFTKCSQNNTCECEPDYFAAEKDMICLPSISGLCYIDDDCTIENSYCHYNRCQCKKFYLLLSRLLLLIVCIPFYSELLGHPCQKDKDCEFSENFICSSDGICSCSQNFYALEDRTKCLPKIGGPCSIHQDCRVKNSFCLNGRCQCNRDCSAVSENECVLKSSAVYCDQAIECGEPWHAGCSPDHNCFCKTNNTLVNKSTCSPMLGGPCLKNHQCVVENSVCKDFHCKCQSPNFKPVANNLDRKYTKCSEHGKCECELNYAKIDFSTCRPLIGSFCERDIECYPDNSVCTNERCYCADGFIPLSNEQCLPTFLELSCKSGEEECQEAEFLLCNEGKCYCPANHVIVDGRNCLPLLNEICSQNEPCVVFNSDCINGRCKCNPNFVAQSNNRCLASKFILVLLAQLYGKCKNDDDCSYIKNSTCSKYNECVYSINYNVTSFSPPLGNNCTTNADCLIGNSTCVDFTCQCRPYFEIMHSEKCIPVLKKPCRSNSDCINVPFAECSKNKTCICKSTYVTSENGACLLPVIGFCTKNSDCISKSSYCHSNRCQCTRNFVGQIIDGVFKCKTKSLGSSCETDHDCSTIKYSKCSHDKICVCLETYYALDNGITCVPGIGGYCSGDIDCAFANFRCFSSLCKCQPGYVSVSDNQCVLKLSAVSCKIGIECGEHWHSGCSLDHTCFCKSNNTQVNQATCSPILGGACFKDDQCTVKNSICTSFHCRCNEPVFKAVAINMCLLCVNGYDCTDRKYTKCSEDSKCVCESNYVKDDFSTYRPLIGSFCEKDIECFPDNSLSSNSSKEEYQAAEFLLCNQGKCYCPANHVIVDGRNCLPLLNEICSQSKPCVVNNSDCVNGRCKCNPNFMAQSNNRCLASKYHYHENESFRIFNVRFILILLALLYGKCKNDDDCRYIKNSTCFKYNECVFSINYNVTSFSPPLGEDCSKDAHCSIENSTCVDFTCQCRPYFEIMHGEKCVPVLKKPCRSNYDCINVPFAECSTNKTCVCKSTYVTSENGACLLPVIGFCTKNSDCISKSSYRHSNRCQCTRNFVGQIIDGVFKCKRISLGSPCESVHDCGTTRNSQCSNGVCVCHENYYALDDGITCVPGIGGYCSGDIDCAFANFRCFNNFCACQRGYISVSKNQCALKSSAVSCNIGIECGEHWHSGCPLDHTCFCKSNNTQVNQATCSPILGEACFKDDQCTNTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HPJ2</accession>
    <name>A0A8J2HPJ2_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Similar to jub: LIM domain-containing protein jub (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HICCMSTLAB_LOCUS10500</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5101598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HPJ2"/>
    <dbReference type="OrthoDB" id="25414at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005912">
        <property type="term" value="C:adherens junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007010">
        <property type="term" value="P:cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035331">
        <property type="term" value="P:negative regulation of hippo signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001666">
        <property type="term" value="P:response to hypoxia"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09355">
        <property type="entry name" value="LIM2_Ajuba_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09438">
        <property type="entry name" value="LIM3_Ajuba_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000037">
        <property type="entry name" value="LIM domain-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047172">
        <property type="entry name" value="Ajuba-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047247">
        <property type="entry name" value="Ajuba-like_LIM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047248">
        <property type="entry name" value="Ajuba-like_LIM3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24219">
        <property type="entry name" value="LIM DOMAIN-CONTAINING PROTEIN JUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24219:SF4">
        <property type="entry name" value="LIM DOMAIN-CONTAINING PROTEIN JUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0440">LIM domain</keyword>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="LIM zinc-binding" evidence="6">
        <location>
            <begin position="597"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="domain" description="LIM zinc-binding" evidence="6">
        <location>
            <begin position="664"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="57"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="130"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="209"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="505"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="60"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="226"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="331"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="352"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="379"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="389"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAG5101598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="747" mass="82284" checksum="2C29641F3364E522" modified="2022-05-25" version="1">MCDSADSYVQKLSYLHLNEDGDRVPGGGGAIGVPGHIGGSKPEAQVPISGDQLKHHHYLQQHYQQQQQQQQQYSRSNRSMSAIDNYIDEHTQSYDRELPRYPVSKSIDLEDRNPVYENIEYYPGPTHPPYYHSLEKKSPKSSPRTSLAGDCYDPSFRKAQPQVPTNKYTVSPAKELPPYEAPPVYENIQEINYLDDAAQIPSINPRYLTSSSSASDLQARGSTYVPPSELQPQLQQPPRMNPSYDSSPRHSETHYTRMSNEHVPGVGVGVGPAGSYRSLSQVTDPGQYRGENGQFKYPSEPRHSPVYGTRSTDARLPGYTPANPRNIMPATWNTGERYNSSPSREYAARTPVYSSNKTNEGHESPSSNRSSPLYAIPHAGRDQSRSRDSGPTQQDSRQQNQSLKHPSSPVHPPPSPKGHPALQQPVSLPPSAPVTSRPAAQYPPSPVRGQVQPPVNSATVPVDDLAPVPRITSLPPGVTSGVAGPVFLNAGVPVLQKPPAELNAPVIDKRPVPSPSPTTKTIQGKGLLPYSVTPARPSGPTEAERKIEELTRQLEEEMEKQEEEGEYFGICHTCGEKVTGAGQACQAMGNLYHTNCFICCSCGRALRGKAFYNILQAMGKSYHPGCFRCCVCNECLDGVPFTVDVDNKIYCVNDYHRMFAPKCASCGKGITPVEGTEETVRVVSMDRDFHVDCYICEDCGMQLTDEPDKRCYPLDGRLMCRACHIERISLTQPRAPQPVSASYQYMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HPQ3</accession>
    <name>A0A8J2HPQ3_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Similar to Dcaf6: DDB1- and CUL4-associated factor 6 (Mus musculus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HICCMSTLAB_LOCUS13000</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5107963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HPQ3"/>
    <dbReference type="OrthoDB" id="4869960at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080008">
        <property type="term" value="C:Cul4-RING E3 ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045151">
        <property type="entry name" value="DCAF8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15574:SF39">
        <property type="entry name" value="DDB1- AND CUL4-ASSOCIATED FACTOR 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15574">
        <property type="entry name" value="WD REPEAT DOMAIN-CONTAINING FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="45"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="297"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="387"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="490"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="592"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="637"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="316"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="517"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="598"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="637"/>
            <end position="646"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAG5107963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="838" mass="94424" checksum="1AB7A9C4013B3969" modified="2022-05-25" version="1">MKRTKSNFFNDLYNQPYDYNAKVKLYNSCKASLELVQRMSLLKRLKVHNGCVNSICWNHNGEYILSGSDDQHLVLTNVYNYKVLKDYKTSHRANIFSAKFLPNNGDHRIVSCSGDGMILYTDLMRTSETFHNQFTCHNGTTYEIATVPGEPHSFLSCGEDCSVRYFDLRVKSACNTPRCKEDILILRQRPVTAMSINPAMPHYLAIGCSDSSVGIYDRRMLSIGERNWTDEKSVNWTSPVSVFTVPEFEGHAYRITSLCYSPDGNDVLVSYSSDHIYLFSAKHQGSVCLKKDCLSEKSTNKRPPVRSPQPVRRLRLRGDWSDTGPDARPEREGGRRSGEIAQARPMLHTSLMQRMTDVLSRMLNDPATRAALSGDGGDNIQGVIDQHTESQQPEESIEINEERSNEVQVMETEPNYPALEDSQDNNMEIGEENNLNSNNSEVVSANELEQSSAINNSSSESADEINIINEQSEHNSINNETNQTENLIQSHVSPCLPRDKITRNQITDGDNNRSDEINPDNDDDDADDTSMNVDSTRDETMMENLQDRLTSMRDGFLEKHGSEPAVSLTYSDKSSTGATISLGVANEVIRDSYHPGPSGSQNLSSKLVTSTIPSSSYDNKSAFNHKCDHEQIEEEDVYTDSDDEETEMAKKSHRRERNPIEAEMDEAVTNARSSLGCEQSFNVDGSKEFHVRQKYMGHRNARTMIKEANFWGNDFVMSGSDCGHVFIWDRETAKLCMLLEADQHVVNCLQPHPYLPMLATSGIDYDVKLWAPVGEEAHFNTSFAEDLQKRNAVMLEETKDTITVPAVFMIRMLACLNQIRGRGRRRRSGNEADELRGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HQK1</accession>
    <name>A0A8J2HQK1_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS12700</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5107340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HQK1"/>
    <dbReference type="OrthoDB" id="10426799at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5107340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="89" mass="10142" checksum="CFAF0BA6D57B7265" modified="2022-05-25" version="1">MSLPVRSCLCRRHSERFEGPHGPRQWLRLLRRSTCSKRGSNSKFSTERTKSKGGASLMSPPGHPGTCPNNLKRGSNYNRRVETIRKFTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HQS6</accession>
    <name>A0A8J2HQS6_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Similar to CG9231: UPF0389 protein CG9231 (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HICCMSTLAB_LOCUS12851</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0389 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5107653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HQS6"/>
    <dbReference type="OrthoDB" id="8193498at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009432">
        <property type="entry name" value="DUF1075"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13674">
        <property type="entry name" value="GROWTH AND TRANSFORMATION-DEPENDENT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13674:SF5">
        <property type="entry name" value="UPF0389 PROTEIN CG9231"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06388">
        <property type="entry name" value="DUF1075"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="116"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAG5107653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="171" mass="19611" checksum="46E6CAE2DD4BF609" modified="2022-05-25" version="1">MSYVTVICVRADEHLSSIQHPIKMSGFLVRVRPFVRTVRGFRTNSILRNVKPEPSTSGAKPQEASDAKYVINEHHLSNFEKRILVFAKKYPSVKDVPDKISAEVMQNCMSKARIRLANYMMALTALSCLTIVIMGNLKKKDKMEEMKAQHDDFRRQITAEFRESVKHDANK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HR83</accession>
    <name>A0A8J2HR83_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Palmitoyltransferase</fullName>
            <ecNumber evidence="10">2.3.1.225</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HICCMSTLAB_LOCUS12894</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:36683"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="2.3.1.225"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="10">The DHHC domain is required for palmitoyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the DHHC palmitoyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.225" evidence="10"/>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5107739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HR83"/>
    <dbReference type="OrthoDB" id="4096362at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006612">
        <property type="term" value="P:protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001594">
        <property type="entry name" value="Palmitoyltrfase_DHHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039859">
        <property type="entry name" value="PFA4/ZDH16/20/ERF2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22883:SF43">
        <property type="entry name" value="PALMITOYLTRANSFERASE APP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22883">
        <property type="entry name" value="ZINC FINGER DHHC DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01529">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50216">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0564">Palmitate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="31"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="55"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="159"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="203"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="domain" description="Palmitoyltransferase DHHC" evidence="11">
        <location>
            <begin position="113"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU079119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAG5107739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="681" mass="76687" checksum="95835DA69CD4EBF1" modified="2022-05-25" version="1">MPHVTRKWELFPGRNRFCCDGRVMMAPQTGVFYITLCLIAGTSALFFIYDCPYLALHITPAIPVIGGLLFMFVMSALLRTSFSDPEVPNNGNSPTYRPPPRTKEILVKGQPVKLKYCFTCKIFRPPRASHCSLCDNCVEGFDHHCPWVGNCVGRRNYRYFYAFIVSLAFLCVFIFACAITHLIMLTRDDRPFLDAIKNSPGSVVVGVVCFFSIWSILGLAGFHTYLTSSNQTTNEDIKGSFSSKREQESFNPYSHGNICGNCFYVLCGPAPPSLIDRRGIVTPGYRAERERTCEDYVIANNKAYGTVKVMQPQANGHSIPSHVDNDITGSMNNLVAGQRSPRIESLNGELTLMSQLPRCPVELPKYRQYTNEVYIPKYSTPRRCAQDRVQPGDAYAAEIERLNAEVQKFNYKCEETLQRYPQRCREEYQRCSENNLIHNQQQYTVDQKYAIDLQKYPRGYSEDYLRYGDIDNDNDDGYRKSIDLQKFPQRYSEDPSHSYHSPQTLKYNNLRCNQHGFKYPISKNILPNRILGSGNIPMIGQSAIGLVVNRFGSAPLNYDMAFMDNNSICPGESAEDNLMNRRSTTNSVSHLVSNEMPLASLSIPPIDIDEIAPLPPKQSVIISPVLGTTMPQMTVTTPLSASRLRLLQDTTMIESALDLDSLEESSVGRGSQTGLIKIGIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HRZ1</accession>
    <name>A0A8J2HRZ1_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS12182</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5106282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HRZ1"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="30"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5106282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="62" mass="6722" checksum="78A7FA6D5EEFC312" modified="2022-05-25" version="1">MEMEMNAEMERPACLMPSVSAGLTEDGSESGEPSAAGSSAGSIYCTLERDYARVFDQYYSLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HTU7</accession>
    <name>A0A8J2HTU7_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Similar to Evi5: Ecotropic viral integration site 5 ortholog (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HICCMSTLAB_LOCUS13375</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5108714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HTU7"/>
    <dbReference type="OrthoDB" id="295078at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.80:FF:000002">
        <property type="entry name" value="Ecotropic viral integration site 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.270:FF:000003">
        <property type="entry name" value="Ecotropic viral integration site 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.750:FF:000003">
        <property type="entry name" value="GTPase activating protein (Evi5)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.750">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050302">
        <property type="entry name" value="Rab_GAP_TBC_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219">
        <property type="entry name" value="RAB GTPASE-ACTIVATING PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219:SF22">
        <property type="entry name" value="RAB-GAP TBC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="6">
        <location>
            <begin position="140"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="72"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="400"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="505"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="641"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="82"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAG5108714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="854" mass="98808" checksum="2EAD0F6DBBE68562" modified="2022-05-25" version="1">MSINLIENLSNKINWDFGCKAIIILSALELDLNFKKVSSENNIISTDELALLGKLEEANRLIESDVKSCNSLQSNHSRKSSESFATPASGSSGEDETAARRHTPTDGEVDVWKRWGHIVADWENYWRKHKDVIKELVKQGIPHHFRGIVWQLLCGAHDSPVKKQFAEYIKSTSACERIIRRDIARTYPEHEFFKEKDGLGQESLFNVMKAYSLHDREVGYCQGSGFIVGLLLMQQMPEEEAFAVLVALMQEYRLRDMFKPSMAELGVCMYQLEHLVADTYPELSAHFTAQSFHTSMYASSWFLTLFTTALTLPLACRIFDVFLMEGMDIIFKVALAMLDLGKDDLLSLDMEGMLKFFQKELPGRAENDPDVLMNLAYGMKINPKRMKKLEKDYTVLKMKEQEEMVELRRLRAENRLLRQRTELLEAESAELADKLVRGQVSRAEEEETTFVVQRELAALRHTHLETSHQLEQAHEELRSLSMLLEENMSSKQSSIDEMSLKAEALSQKEEMVECLQQELVRVRLHEAEKDATIRDLRARIQELEQDKKTLRESTPDNSVAHLQEELIAVKLREAEANLSLKDLRQKVGELSTAWQRHLQEHRSAQSTPAADSTPKKLLFWENRGHEIQKLEEDLMSSRLREMEVLTEVKELRLKVMELETQVQVATNQLRRQDEGEKLIREELEISSAKIKELTSKLREQMHKYSDLESKMKDDTMMARIRDAEHAQHVAELTQKISLLELKNEEMYAEGELRSNLDDSDRVRDLQDKVAELKAEFPTPITSPETEPWRWLDLFYCPTSRIMRLKNSKYQWTGSTERIGRNTSIDTDSEFDERDLRICLQDQLNNVTISDSSRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HTX6</accession>
    <name>A0A8J2HTX6_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Dorsal.2_Tollpathway_Cc</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS13484</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5108848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HTX6"/>
    <dbReference type="OrthoDB" id="7881762at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007249">
        <property type="term" value="P:canonical NF-kappaB signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033554">
        <property type="term" value="P:cellular response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045087">
        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038061">
        <property type="term" value="P:non-canonical NF-kappaB signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048935">
        <property type="term" value="P:peripheral nervous system neuron development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002225">
        <property type="term" value="P:positive regulation of antimicrobial peptide production"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035206">
        <property type="term" value="P:regulation of hemocyte proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034097">
        <property type="term" value="P:response to cytokine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008063">
        <property type="term" value="P:Toll signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01177">
        <property type="entry name" value="IPT_NFkappaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07887">
        <property type="entry name" value="RHD-n_Dorsal_Dif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.340:FF:000006">
        <property type="entry name" value="Dorsal isoform 1-B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000046">
        <property type="entry name" value="Nuclear factor NF-kappa-B p105 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.340">
        <property type="entry name" value="Rel homology domain (RHD), DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002909">
        <property type="entry name" value="IPT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033926">
        <property type="entry name" value="IPT_NFkappaB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000451">
        <property type="entry name" value="NFkB/Dor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008967">
        <property type="entry name" value="p53-like_TF_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030492">
        <property type="entry name" value="RHD_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032397">
        <property type="entry name" value="RHD_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011539">
        <property type="entry name" value="RHD_DNA_bind_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037059">
        <property type="entry name" value="RHD_DNA_bind_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24169:SF25">
        <property type="entry name" value="DORSAL-RELATED IMMUNITY FACTOR DIF-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24169">
        <property type="entry name" value="NUCLEAR FACTOR NF-KAPPA-B PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16179">
        <property type="entry name" value="RHD_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00554">
        <property type="entry name" value="RHD_DNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00057">
        <property type="entry name" value="NFKBTNSCPFCT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00429">
        <property type="entry name" value="IPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49417">
        <property type="entry name" value="p53-like transcription factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01204">
        <property type="entry name" value="REL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50254">
        <property type="entry name" value="REL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RHD" evidence="2">
        <location>
            <begin position="68"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="408"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="452"/>
            <end position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5108848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="572" mass="63556" checksum="98459AB3B1E155AD" modified="2022-05-25" version="1">MDQYHDMNDNINISDVIEVIQTTDPEFVEEARCRNQHQQQQQQQTLNMLSGGGVETVKPVLAGNTSSRVGSYVEIIEQPASKALRFRYECEGRSAGSIPGVNSIPENKTFPSIRIVGYKGRAVVVVSCVTKDPPYRPHPHNLVGKEACRRGVCTLEISSENMTVTFANLGIQCVKKKDIEEALRIREEIRVDPFRTGFSHKRQPASIDLNAVRLCFQVFLEGTEPGKFTVPLTPVVSDPIYDKKAMSDLVICKLSHYSAPVAGGMEMLLLCEKVAKEDIQVRFTEERDGQIVWEGFGDFQPSHVHKQVAISFRTPTYRIQQVEHPVQVYIQLRRPSDSATSEALPFQFLPLGADDPDYLKRKRKKLNNSPSLLVQQVQAEVNQHGVGIHNHQMQYNFNLIKPEPTDSLYPSMAGGSSSPMYPVGSPISPSNLHTLRQIRSPRRTPSPMGPSYSMQQPQTLTPQYHSPSGHASPNLPAQLMYNQSISLSRVTPEPSQDVPGINHQGFHNPLVNAENVNNLLDFGINQCSFDINQLSGSLNPLDSDDLAVLGNAFTESFSSGLSLSDSQNKVIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MB73</accession>
    <name>A0A8J2MB73_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS2545</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001117">
        <property type="protein sequence ID" value="CAG5077739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MB73"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5077739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="72" mass="7787" checksum="BC60950C76F989D0" modified="2022-05-25" version="1">MRRIPFSASVIFINPGRRVCAKRNAAEAKLLAIAGSPPEDSRPRVSGQETISPTLVLNFSVAAVVEVRALRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MB80</accession>
    <name>A0A8J2MB80_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS3210</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5081173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MB80"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5081173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="156" mass="17771" checksum="231E921BDFB702C3" modified="2022-05-25" version="1">MNSANSTAGVAFACGLRPRWETVLDLRGGLYGEERTGCRPNRRGLELLLGRYLHRRYKQGSSSLSSIKYYKNKNKNRTGTRVKVIVHLGEEIAETKRRNKYGNNVQEYLFLGGKKSSEKKWEDEEIVVSALAGEDVIVELKLNPEDSRDPQHFLLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MI37</accession>
    <name>A0A8J2MI37_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS4265</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5085062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MI37"/>
    <dbReference type="OrthoDB" id="7697417at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46704:SF9">
        <property type="entry name" value="BHLH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46704">
        <property type="entry name" value="CXC DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5085062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="621" mass="71975" checksum="3991F43A9B7C4D34" modified="2022-05-25" version="1">MSELMNSYFAHREACLNGEFGKTVQFYTTYINFINYYYLLNRSIRTGDFEIFKYVLPKIANLFFVLNQPNYARWLVKYHDNLLKIGETHPEISEAMKKGYLGIQRTDKSFSRHPIDLTLEQTINAEAVKRLVGIINFTNSISARQRWCKSHEIRSSVISHTYEVTGLQKRQDVTNDLEKHNIKRDTKLLKNFISSFSKFMNPFDSSLDKNFLHNISNGKSASENVQKFLLAWRVLVTTCGKNLFQNVQNHQTDLKNQSNDRNCKEKATSAPRVDIIFDQYFSPSIKDYERTLRCEMNDLDFKITGPMQVRPVDFNKELKNIKFKQAFVTFLIDHWATQEMAPLIGETIINLSYDKCYTYKVESNVVIREENNDLSCDDHEEADTKIVHHVCKIDNDVATNILIKSCDTDVLVIMLGNMDHLECDSLSIYMEYGNNNKKRILNLSQLSIELGPKENEDYQNAFTNLGTAHITGCRNEEFLVSEKFVCEMYGFKNLADINTARFEKFCSTYKADNPDEPFEKRFKNYDASNLPPCKAELKQQLLRTQYITSIWRNAHLRFPSTLAPTRNGWDLQNGKLEFYWFEGDCMPPSVMDALKANEAQNTTISEDLEEVIAEPDIGETA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MIH5</accession>
    <name>A0A8J2MIH5_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Cc_odve66_31</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS3732</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5083105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MIH5"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5083105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="169" mass="20262" checksum="27649F579CBDC4D1" modified="2022-05-25" version="1">MQITDLCDVGCHYLKDYVNEPNKPKYLKWGNDIVKLVLDEKLKGFNLKNYSDNFDDLVCSIGLFCIMFEYVADKSEYDDTKQLCDEFILKLVPKLKNRGKYSTYFQQFDFYTNTLRMMTNYLYRKELFNQESNDPEMIEFNKQIKDVSSTMKQGEVKFRYEIYLPLIKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MII0</accession>
    <name>A0A8J2MII0_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ZP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HICCMSTLAB_LOCUS6895</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5093525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MII0"/>
    <dbReference type="OrthoDB" id="8249838at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001507">
        <property type="entry name" value="ZP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39959">
        <property type="entry name" value="RE44287P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39959:SF1">
        <property type="entry name" value="ZP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51034">
        <property type="entry name" value="ZP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035240316" description="ZP domain-containing protein" evidence="2">
        <location>
            <begin position="17"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="380"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="domain" description="ZP" evidence="3">
        <location>
            <begin position="25"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG5093525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="443" mass="49804" checksum="0E992839EB6352D9" modified="2022-05-25" version="1">MMWRILVFGFFAVTLAQDYEVSDIQCSPPTSPTDLLTAKIRRPVGFKGSPLFADDRAADPLTDIQCQIRPDPADALEDNYLLKVTDFSRCGILKRNGFIHLRIWFPAFPGVVMLADQELILMCRPPEPTLLRHKAAGFAGTLNIYTYSPHGARVSGIVEETPGRLEYEVALYREAIGNSSESSIGAETVDQAVPIGTKLQLRARISAESAWGYIKLIEVTVSPDPDNPHAQGSVVLVKDGCRNRDFASIIPHQPSRYRERKNEVFLDFEAFLLSSMRERSTLWIHSQIKACMEPHDCQPDFCLDLFEPSGHGKRKRRADGFVEEMSGNGSNEPKVERLIQNYNDSTQFTKIKENIEYTVMMPSDLYDKVALGLEGNCGNFLYVATGLGVLLMFSAFIMCYLISRLHNITTSVPQNKSIDELIRERSRKYCEPAPGYTGRTIMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MIS5</accession>
    <name>A0A8J2MIS5_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein NATD1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS4793</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5088302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MIS5"/>
    <dbReference type="OrthoDB" id="74247at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5088302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="93" mass="11230" checksum="2808471282424020" modified="2022-05-25" version="1">MNTSTLFISHFSRIIIQTRCLFGVHHNPKRQIFYIKLNNNERATLLYKKNDNILDIKSVYVPEEYENRGIARLLAEVFYFYNYLIMILKLRDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MJT7</accession>
    <name>A0A8J2MJT7_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to ADCY10: Adenylate cyclase type 10 (Oryctolagus cuniculus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS8044</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5096107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MJT7"/>
    <dbReference type="OrthoDB" id="194468at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004016">
        <property type="term" value="F:adenylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16305:SF28">
        <property type="entry name" value="GUANYLATE CYCLASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16305">
        <property type="entry name" value="TESTICULAR SOLUBLE ADENYLYL CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5096107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="570" mass="66962" checksum="AB6B4ACCF7D30574" modified="2022-05-25" version="1">MKHSETEITPQLFSDLNFTNCQCNLILITTFSQILDHCMGIDRKDKALTTMLEFARVLLEISNVPQAKKLLNDADDILSRIFKARDDELVTVPYLKGKIRTLQAKCDLHTGQIEEVKNNLKEAIRSMGYWWPNSNPIILLKAKYFFQQLKFMMCKKNHMINNYNGDATKYHDQLSQCLSEMFIILQMEGMYEHAQLAAAWSLSSALMSKKELVTLCTAFANIIIIGHTFNNEVFMTNVENEGMKFCNNKSADLTEQELKSIIKLYTSIFYARLSRNKIRKASDLGLIVYQISKNVRSNYFQILILSQLIYALMLEYRCEELIPLLKELKLIYNTSVDKSVRMWYYEVCLSIQLETGIKLISLQKCEQYYQEEGKIIVELKNVEVKRRFCISMELWYLRMEEWESAEIWNKRTINVDSHKISTLNESIVAINQLECLLLSYVRSLDRKNVNALQIILTDIKKQFKIIEKIIKTSKFILSRYVFMKAYFNMIQSRHQTSIKFLEQSKSIAYNISNQFLYDWINHCEKVWNNSLPIAQQNSWKENYLQSNVERNSFDKESIAFYTLPLPQYLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MJX5</accession>
    <name>A0A8J2MJX5_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Serpin.1_Cc</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HICCMSTLAB_LOCUS8149</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the serpin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5096316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MJX5"/>
    <dbReference type="OrthoDB" id="671595at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004867">
        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.39.10">
        <property type="entry name" value="Alpha-1-antitrypsin, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.497.10">
        <property type="entry name" value="Antithrombin, subunit I, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.310.10">
        <property type="entry name" value="Serpins superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023795">
        <property type="entry name" value="Serpin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023796">
        <property type="entry name" value="Serpin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000215">
        <property type="entry name" value="Serpin_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036186">
        <property type="entry name" value="Serpin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042178">
        <property type="entry name" value="Serpin_sf_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042185">
        <property type="entry name" value="Serpin_sf_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11461:SF211">
        <property type="entry name" value="GH10112P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11461">
        <property type="entry name" value="SERINE PROTEASE INHIBITOR, SERPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00079">
        <property type="entry name" value="Serpin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00093">
        <property type="entry name" value="SERPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56574">
        <property type="entry name" value="Serpins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00284">
        <property type="entry name" value="SERPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0646">Protease inhibitor</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0722">Serine protease inhibitor</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035202783" evidence="5">
        <location>
            <begin position="20"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="domain" description="Serpin" evidence="6">
        <location>
            <begin position="27"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAG5096316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="387" mass="42882" checksum="05964C64293712A6" modified="2022-05-25" version="1">MWKLISLILISKTFEGLNAERNNYFGIELLQGINEQTTGNVVISPLSVKSALTILSEATGGDTREELLSALRLPSDISQIRDISKQILQSLLTTTNGTEIDAANRLWLEQGTQLSDNFNNILKSNYGGDTSNVAFSNIQSTVLTINNWVRQFTRGHIDSIVDSSSLSPATKILLTSALYFKGNWKKAFDKNLTRNRCFNIPNQACHTVPMMESVSNYFYASIPDLKAEVVEIPYDDDKISMLVFLPTKEGLQSLSILSRDLSYTSISSILNSLRETELILLMPRFSVETKTDLRSTLETLGIRQLFTVNANFTNFLINGGAKVDSVLHNAKIEVNEDGTVAAAVTGLSVVPLMGSSIDAFRVNRPFLLMLIDRQTNSIIFSGRVIRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MKA5</accession>
    <name>A0A8J2MKA5_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS5186</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5089309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MKA5"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5089309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="163" mass="18694" checksum="73F1A29A70236D49" modified="2022-05-25" version="1">MGWLTVKSRRKPCYLRELFIEDPNLRRSERLAAKRNNISFPKERPKIVLTISLQLDSTSRGALAPPMSVLTHPGCMQATRIPSCSRSMLIDLINYLGEHYRCHGINQESFRQLFGLDHPNPREFGSDSCIVEQYIESGFSDLRADLIDHAGEVLEVLEIFKYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MKJ0</accession>
    <name>A0A8J2MKJ0_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Medium-chain specific acyl-CoA dehydrogenase, mitochondrial</fullName>
            <ecNumber evidence="5">1.3.8.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">HICCMSTLAB_LOCUS3521</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>a medium-chain 2,3-saturated fatty acyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = a medium-chain (2E)-enoyl-CoA + reduced [electron-transfer flavoprotein]</text>
            <dbReference type="Rhea" id="RHEA:14477"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="ChEBI" id="CHEBI:83723"/>
            <dbReference type="ChEBI" id="CHEBI:83726"/>
            <dbReference type="EC" id="1.3.8.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 15">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism; mitochondrial fatty acid beta-oxidation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 15">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.8.7" evidence="5"/>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5082306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MKJ0"/>
    <dbReference type="OrthoDB" id="434771at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070991">
        <property type="term" value="F:medium-chain fatty acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051793">
        <property type="term" value="P:medium-chain fatty acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.540.10:FF:000010">
        <property type="entry name" value="Medium-chain specific acyl-CoA dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.10:FF:000011">
        <property type="entry name" value="Medium-chain specific acyl-CoA dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.110.10:FF:000007">
        <property type="entry name" value="Medium-chain specific acyl-CoA dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="entry name" value="Acyl-CoA dehydrogenase/oxidase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050741">
        <property type="entry name" value="Acyl-CoA_dehydrogenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006089">
        <property type="entry name" value="Acyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48083:SF2">
        <property type="entry name" value="MEDIUM-CHAIN SPECIFIC ACYL-COA DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48083">
        <property type="entry name" value="MEDIUM-CHAIN SPECIFIC ACYL-COA DEHYDROGENASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016578">
        <property type="entry name" value="HsaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00072">
        <property type="entry name" value="ACYL_COA_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00073">
        <property type="entry name" value="ACYL_COA_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 15" id="KW-0274">FAD</keyword>
    <keyword evidence="9" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="7 15" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11 15" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase N-terminal" evidence="18">
        <location>
            <begin position="30"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA oxidase/dehydrogenase middle" evidence="17">
        <location>
            <begin position="145"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase C-terminal" evidence="16">
        <location>
            <begin position="255"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="19">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00019125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="CAG5082306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="413" mass="44957" checksum="B13F547D2FFF4B81" modified="2022-05-25" version="1" fragment="single">QVFSNITKQALARNFSVSSRLSSGYSFELSETSQEIKDTADKFAREEIIPVATQYDKSGEYPWPVVKKAWETGLLNTHAPKDIGGLELGAFDGCLIAESLSYGCSGMMTAVESSGLAQWPIILGGSKAQQKKYVGRLLEEPLVAAYCVTEPGAGSDVAGIKTKAVKKGNEWILNGTKMWITNGGVANWYFVLARTNPDPKAPAGKAFTGFIVERDWPGVSPGRKEWNMGQRASNTTMVTFEDVRIPEENVLTGEGAGFRIAMETFDATRPMVACGAVGLAQRALDEALKYSLERHTFGKPIAEHQAVAFLIADMEIAVETARLAWMKAAWAADKKLPTATKLASIAKCYAADIANRVASDAVQVFGGAGFNSDYPVEKLMRDAKIYQIYEGTSQIQRLIISRHIFKEAKAKAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MLS5</accession>
    <name>A0A8J2MLS5_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS3884</name>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS3885</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5083605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5083609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MLS5"/>
    <dbReference type="OrthoDB" id="7641510at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5083605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5083609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="107" mass="12500" checksum="5749CFE2E2C7FD4B" modified="2022-05-25" version="1">MAHCTTSVSWFISKFVFNLFTIIFVYGGFLKEKRIECLCAAAERDHKRQLLKGEEKSRSRCMCHRWRSSVYPCGCKRKKVFEDCVGDLRCEVTKQEEVSRNKCCCGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MMF6</accession>
    <name>A0A8J2MMF6_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Similar to Odf3l2: Outer dense fiber protein 3-like protein 2 (Mus musculus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS7364</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5094038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MMF6"/>
    <dbReference type="OrthoDB" id="440566at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051291">
        <property type="entry name" value="CIMAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010736">
        <property type="entry name" value="SHIPPO-rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21580:SF28">
        <property type="entry name" value="BOREALIN N-TERMINAL DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21580">
        <property type="entry name" value="SHIPPO-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07004">
        <property type="entry name" value="SHIPPO-rpt"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5094038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="245" mass="26760" checksum="E59342C4D7F7FE15" modified="2022-05-25" version="1">MMTTRVIEKPMLSCKSRGPGPAYSLPPVLGFEKHDLSRKRNPAYSITSRHDEKLYVTASPGPNRYNTYHLTRQGIEKPPAFSIAGRAPFVVIGSGPGPGAYHPETCPPVNHSRTSPSFSIQSRLKPDHLSLDGPGPNSYVVPSSLGPKIPHKKTCGAVSIKGRTSDSSKYVGPGPSDYGNPNYNVVKKQYPAFSLKFRQQPLSSYSSGPGPMYNPTYNPGKQPPAFSFGIRHSEWEAQPCTYLKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MMM0</accession>
    <name>A0A8J2MMM0_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Dop2R</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">HICCMSTLAB_LOCUS9023</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5098089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MMM0"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001591">
        <property type="term" value="F:dopamine neurotransmitter receptor activity, coupled via Gi/Go"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15053">
        <property type="entry name" value="7tmA_D2-like_dopamine_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000233">
        <property type="entry name" value="CLUMA_CG012980, isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000247">
        <property type="entry name" value="Uncharacterized protein, isoform B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24248">
        <property type="entry name" value="ADRENERGIC RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24248:SF125">
        <property type="entry name" value="DOPAMINE D2-LIKE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6 11" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="7 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 11" id="KW-0675">Receptor</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 11" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 11 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="220"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="256"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="286"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="335"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="375"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="649"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="688"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="14">
        <location>
            <begin position="235"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="453"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="525"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="532"/>
            <end position="551"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CAG5098089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="726" mass="77999" checksum="20DD6C2338AE3795" modified="2022-05-25" version="1">MGRRLAKSYSMTDGGNISYEHLENPYPDNPIADLSATTSSSGLPELLTTGAGEFTKNKVYGEENGGSGLSGIEFGIGIGWSNDSGLITSTTTNNIIINGSKINGGDGESGGGGGGASNLSSSITDNYTSISDLFVFSDLNDYINRLNYSGFGNLSSYYEGGVVAGLNLTGTVNASCLSLSTLSSLSSINQTIGVIPGGSVVSVGGQCSGSEDQESDVNNWWALILVIVPCLTLFGNVLVILAVFRERTLQTVTNYFIVSLALADLLVAVVVMPFAVYVLVNGAWALSAFICDFYIAMDVTCSTSSIFNLVAISIDRYIAVTQPIKYAKHKNSTRVWMTILLVWAISAAIGSPIVLGLNNTPERQLDLCVFYNSDFIIYSSLSSFYIPCIIMVFLYWNIFKALRIRAAKARAHKKSNLRDIKPNSIIENVIHTQRVYSVARFAETALGTATLVAPVHEEPTNTASGSNEDEDETPVDPVVVISNDKSAEFFMATVVEEAAVVAKAHLTSSNSTRSDSNNLCLEDAVSSTMEGNSSPSPNPRTTSAPSSSTSSSPPPLRSATQIKKTTNGLNKQGLKKLKSTGSLLPAQFKRSRSVLNVGTGPGVTAGGGPDKVKNYKKPSDSTSRFTIYKANKASKKKREKSSVKKERKATKTLAIVLGVFLICWVPFFTCNVMDALCSKLKMDCQPGVTAFIVTSWLGYMNSFVNPVIYTVFNPEFRKAFRKLMRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MN91</accession>
    <name>A0A8J2MN91_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Similar to prrc1: Protein PRRC1 (Danio rerio)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HICCMSTLAB_LOCUS9545</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PRRC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5100421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MN91"/>
    <dbReference type="OrthoDB" id="4968544at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034237">
        <property type="term" value="F:protein kinase A regulatory subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029001">
        <property type="entry name" value="ITPase-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026533">
        <property type="entry name" value="NTPase/PRRC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026534">
        <property type="entry name" value="PRRC1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23276">
        <property type="entry name" value="PROTEIN PRRC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23276:SF2">
        <property type="entry name" value="PROTEIN PRRC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01931">
        <property type="entry name" value="NTPase_I-T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52972">
        <property type="entry name" value="ITPase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Non-canonical purine NTP phosphatase/PRRC1" evidence="5">
        <location>
            <begin position="197"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="88"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="106"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAG5100421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="391" mass="42037" checksum="85578B0F14925578" modified="2022-05-25" version="1">MTDESNGESTFEFVEKRVEDVSISGETTKIDLISSLSPSVSIITPLSGSSSAGNLLSNVAPPSALPSFIANQSPPLDSLPKEIGQNAVKVESTEKPEEISGDLGVQTKQPQAQGQQTPAESQKPLESVCLEENQSQDMGIVGASLFSWVKDNVVNNSMLSKVAEKAKSSVNSMITTLDPQMHTWISDSGGDVEIVVASNKEVKVSPIREAFQDAFGKATITGVAIDTSAIPAQPVGFAAGVNGAKHRIKYARNALEIPKDIPIIAVQSFLVEIGEDKWYELAVILLDDSKNDVNLQMFTQMTPVPSQFVSTAKESTPDTYPLKTLGLAVSVGSLMSTNLQVNFNEWHHALTVICTLIVLYKSAKIQIGYNLSKYDAKSGRPSFNPFLFLVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MNE1</accession>
    <name>A0A8J2MNE1_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Isoforms A/B/D/L (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS8878</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5097789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MNE1"/>
    <dbReference type="OrthoDB" id="10004641at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="35"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="64"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5097789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="89" mass="10636" checksum="10E2396838B392C9" modified="2022-05-25" version="1">MFVCPKFRNTNWRRQSLLLDQQSAGELLRNSPGGYFCRKCGNSYSRLHSLNRHIKFECGVEPQFECPLCHKRSKHKHNLLLHMRTHQKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MPE1</accession>
    <name>A0A8J2MPE1_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS9394</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5100120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MPE1"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5100120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="63" mass="7252" checksum="0FD966FA7C4231AC" modified="2022-05-25" version="1" fragment="single">MLWLPRVTVVPAASKLVNLIITTLVLTGLGETQFQTNSYNACMRFIIVEQYLLYTKMLIITRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MQ24</accession>
    <name>A0A8J2MQ24_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS9880</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5100807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MQ24"/>
    <dbReference type="OrthoDB" id="4089664at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5100807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="97" mass="11150" checksum="BECBAD69AF0D6790" modified="2022-05-25" version="1">MDGPGTITWEEFVENAKSFARVSDEILDSWELRGDKDLPAQAYLARRVKTFVTRDYLDCQDNVESTKKLIKKDGLNDDDDDDDDDDDLNATFRESIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MQ51</accession>
    <name>A0A8J2MQ51_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Similar to RALGPS2: Ras-specific guanine nucleotide-releasing factor RalGPS2 (Macaca fascicularis)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HICCMSTLAB_LOCUS8058</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5096135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MQ51"/>
    <dbReference type="OrthoDB" id="10254377at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007265">
        <property type="term" value="P:Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13310">
        <property type="entry name" value="PH_RalGPS1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00155">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.840.10">
        <property type="entry name" value="Ras guanine-nucleotide exchange factors catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008937">
        <property type="entry name" value="Ras-like_GEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023578">
        <property type="entry name" value="Ras_GEF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001895">
        <property type="entry name" value="RASGEF_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036964">
        <property type="entry name" value="RASGEF_cat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113:SF368">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113">
        <property type="entry name" value="GUANINE NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00617">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00147">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48366">
        <property type="entry name" value="Ras GEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50009">
        <property type="entry name" value="RASGEF_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ras-GEF" evidence="5">
        <location>
            <begin position="113"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="4">
        <location>
            <begin position="485"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="79"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="81"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAG5096135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="613" mass="69328" checksum="BCCA5D524D6AB9D1" modified="2022-05-25" version="1">MVEMHYTSISHDLPGEFFPSHQGSKDKYFANDTNSSSGNLLPGDMNQGDKIYKDRKEHKEKYRAYRKYSELTPPTLHSYDNYGNSLGSKSNSLPGRSNTTLHGSEPLVATGISPEDLANQLTLLDLSVFKAIRPEELSSCSWNKKNKLLVAPNVVAFTRRFNHVSFWTVQEILNFSTPKQRSEMIAHFIRVAKKLYDLNNMHSLFAIISGLQSAPIYRLNKTWACLSKKDKCTFDKLAEVFSDKNNWTNLREHMVTLKLPCIPYLGLFLTDLVYIDMAHPPSKNNENHQRAIKMNTVLTRVTVFQASEYSGIIPLPDVQRYLNNVRYIEELQKFLEDDHFKLSIKLEPNSPVASSSSSKESVGDVVTGVAALSLSPARGCAGSLRLHAASAANKFVPGHRKCRSLGTNIFGKSNVPPVETNQVTVRHLLDDSVLEEPHLVSPTVDLDENSPETPVDSLNDDCSLLSRVSTLPILPCEIDGVMEPRCSMQGSLRRKVILRDGKKPTVSTWQRYWIQLWTTSIVYFSPKCFKGCDRSDFKREPYKMVSILGWIVEYGDSIFHRDTFLLTDPNKGNVYKFRAGSSEYAEQWVKELRAIVRGMIDKKPVPANLMSFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MR24</accession>
    <name>A0A8J2MR24_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">40S ribosomal protein S3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HICCMSTLAB_LOCUS10814</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5102036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MR24"/>
    <dbReference type="OrthoDB" id="10248446at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001235">
        <property type="term" value="P:positive regulation of apoptotic signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02413">
        <property type="entry name" value="KH-II_40S_S3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1140.32:FF:000005">
        <property type="entry name" value="40S ribosomal protein S3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.20:FF:000006">
        <property type="entry name" value="40S ribosomal protein S3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1140.32">
        <property type="entry name" value="Ribosomal protein S3, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004044">
        <property type="entry name" value="KH_dom_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009019">
        <property type="entry name" value="KH_sf_prok-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036419">
        <property type="entry name" value="Ribosomal_S3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057258">
        <property type="entry name" value="Ribosomal_uS3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001351">
        <property type="entry name" value="Ribosomal_uS3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005703">
        <property type="entry name" value="Ribosomal_uS3_euk/arc"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003219">
        <property type="entry name" value="PRK04191.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01008">
        <property type="entry name" value="uS3_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11760">
        <property type="entry name" value="30S/40S RIBOSOMAL PROTEIN S3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11760:SF32">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07650">
        <property type="entry name" value="KH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00189">
        <property type="entry name" value="Ribosomal_S3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54814">
        <property type="entry name" value="Prokaryotic type KH domain (KH-domain type II)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54821">
        <property type="entry name" value="Ribosomal protein S3 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50823">
        <property type="entry name" value="KH_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 9" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="2 6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="KH type-2" evidence="8">
        <location>
            <begin position="23"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="219"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAG5102036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="242" mass="26667" checksum="24CA619BFED8F18D" modified="2022-05-25" version="1">MAAARSISKKRKFVADGVFKAELNEFLTRELAEDGYSGVEVRVTPTRTEIILMATHTQSVLGEKGRRIRELTSVVQKRFNFKDQTVELYAEKVATRGLCAIAQAESLRYKLIGGLAVRRACYGVLRFIMESGAKGCEVVVSGKLRGQRAKSMKFVDGLMIHSGEPTADYVDTATRHVLLRQGVLGIKVKIMLPWDPNGKIGPKKPLPDNVNVVEPKEEVIHQTPSSEVKTAKDAPPPTPIIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MR88</accession>
    <name>A0A8J2MR88_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS10965</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5102338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MR88"/>
    <dbReference type="OrthoDB" id="7683164at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140996">
        <property type="entry name" value="Hermes dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5102338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="351" mass="40188" checksum="59DB4B05B2360FD3" modified="2022-05-25" version="1">MQRGGRPKHSFWEEGGFQRIRENGKQVASCVKCKKIINNTAEQRLKSHRKSCIWENSDSISESEDNCNITLSKKRRNRSGSYDDNNNSDLKRGSYDEAATPSSSIQLKKEKRKISSFLDSISDKEHLKIDEALSNFFYSNNLSFDLIQDPYFKKFCKILRPAYEVPSEVKLSTTLLEKAHDKFTDRKVNLKEKKGTLLFCKNVAQTNGLEINAITKTGNDTLFLKSWILEEERDYISNYLQMINESSSIALKKYYISVYAVISFINIPKNNRILDSTSASPLLSESISMWHFDCHLETVDTLIAAIHDDSLEIKINRLLNAIKSTDIEEELVKRGGDTLSCQTRCSAFILF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MRQ0</accession>
    <name>A0A8J2MRQ0_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Phosphoserine phosphatase</fullName>
            <ecNumber evidence="4">3.1.3.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">O-phosphoserine phosphohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HICCMSTLAB_LOCUS5838</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-serine biosynthesis; L-serine from 3-phospho-D-glycerate: step 3/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the HAD-like hydrolase superfamily. SerB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.3" evidence="4"/>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5091005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MRQ0"/>
    <dbReference type="OrthoDB" id="27226at2759"/>
    <dbReference type="UniPathway" id="UPA00135">
        <property type="reaction ID" value="UER00198"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036424">
        <property type="term" value="F:L-phosphoserine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006564">
        <property type="term" value="P:L-serine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04309">
        <property type="entry name" value="HAD_PSP_eu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.210:FF:000002">
        <property type="entry name" value="Phosphoserine phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000077">
        <property type="entry name" value="Phosphoserine phosphatase, chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.210">
        <property type="entry name" value="Phosphoserine phosphatase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050582">
        <property type="entry name" value="HAD-like_SerB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004469">
        <property type="entry name" value="PSP"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01488">
        <property type="entry name" value="HAD-SF-IB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00338">
        <property type="entry name" value="serB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43344">
        <property type="entry name" value="PHOSPHOSERINE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43344:SF2">
        <property type="entry name" value="PHOSPHOSERINE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0718">Serine biosynthesis</keyword>
    <feature type="active site" description="Nucleophile" evidence="12">
        <location>
            <position position="75"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="12">
        <location>
            <position position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00015196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR604469-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAG5091005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="279" mass="31846" checksum="0D5EF004ADD1E802" modified="2022-05-25" version="1">MWWFQRLNGTIFSRLINLKSHHNHHHSYKFRKKYFLPKDTSYNNNKFYSLLITLNKMNAEDIKIIWKNADAVSFDVDSTVIQEEGIDELAKFCGKGDQVTELTKKAMQGNMTFQQSLTVRLNIIRPSLEQIKQFIKIHPPKLTPGIKELVDKLHEKNKKVFLISGGFRCLISPVATRLNISQDNIFANRLLFNFAGEFGGFDENELTAKSGGKAQVIKRLKDNYNFKTIVHIGDGATDLEACPPADAFVGFGGNVVRDTVKNGSRWFVYDLNQLKEALD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MS49</accession>
    <name>A0A8J2MS49_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Similar to Trypsin inhibitor (Ascaris suum)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HICCMSTLAB_LOCUS12491</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the serine protease inhibitor-like (TIL domain-containing) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5106900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MS49"/>
    <dbReference type="OrthoDB" id="6236007at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030414">
        <property type="term" value="F:peptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19941">
        <property type="entry name" value="TIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036084">
        <property type="entry name" value="Ser_inhib-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051368">
        <property type="entry name" value="SerProtInhib-TIL_Domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002919">
        <property type="entry name" value="TIL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23259:SF70">
        <property type="entry name" value="ACCESSORY GLAND PROTEIN ACP62F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23259">
        <property type="entry name" value="RIDDLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01826">
        <property type="entry name" value="TIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57567">
        <property type="entry name" value="Serine protease inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0646">Protease inhibitor</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035191199" evidence="4">
        <location>
            <begin position="22"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="TIL" evidence="5">
        <location>
            <begin position="27"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAG5106900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="85" mass="9321" checksum="D8C040FCDF9F5441" modified="2022-05-25" version="1">MAKFLLISVVLVAALVVCVNANTSLKCGPNEEIKGCGACDNTCKERNMMCTMDCRPPECGCKKGFYRNDDRKCVSLSQCPIKPKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MS91</accession>
    <name>A0A8J2MS91_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HICCMSTLAB_LOCUS6365</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5092777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MS91"/>
    <dbReference type="OrthoDB" id="7695469at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027806">
        <property type="entry name" value="HARBI1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027805">
        <property type="entry name" value="Transposase_HTH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23080:SF143">
        <property type="entry name" value="SI:DKEY-56D12.4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23080">
        <property type="entry name" value="THAP DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13359">
        <property type="entry name" value="DDE_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13613">
        <property type="entry name" value="HTH_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transposase Helix-turn-helix" evidence="4">
        <location>
            <begin position="217"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="DDE Tnp4" evidence="3">
        <location>
            <begin position="298"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAG5092777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="479" mass="54215" checksum="DDA756940B5F3915" modified="2022-05-25" version="1" fragment="single">FDGSPWYPKPSDHICSDHFVGGKKSEEELSPSYIPTIFPSIYGSSTVNTSTALNRHKRFMERRIKKQNLTTAVPSENDKFVSRNNEIIIDNLADRCYSTNVKKISQATQVNIFFEPIEMAKTFICNRYIYNDKNDAEVQTSITEHIESKWKIPTKNFSEKSCGTDHMIRVDKCVATGNKCFCGFKSIRKDDQLMELAGVTFNNFDFLLKKMSSMNKCLISNEDRLLIFLMKIKTGLTFSTLSALFDVHRTTISRIFHTTLQNLVSATTNLIYWPDSETLKATMPAFFRLNYGNTRVIIDCVEFKIEVPASIDNSVYRCPNNDKAFTAKILIGITPGGFLCFKSKAVGARITNSQLIVDSGLINNLKGGDVILTGKKCYGINAAIYQSEKQIKVVTPKISEDKTNCQRAEPEKPNSNVAKVQIHIKKMIESLKVYKVLDNIPENLFDHVDDIIHICCVLVNLNKEKVNIVIKHSQPIELL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MSN1</accession>
    <name>A0A8J2MSN1_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Similar to Pigs: GPI transamidase component PIG-S (Rattus norvegicus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HICCMSTLAB_LOCUS11950</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="pathway">
        <text evidence="2">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PIGS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5104334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MSN1"/>
    <dbReference type="OrthoDB" id="28748at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042765">
        <property type="term" value="C:GPI-anchor transamidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016255">
        <property type="term" value="P:attachment of GPI anchor to protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019540">
        <property type="entry name" value="PtdIno-glycan_biosynth_class_S"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21072">
        <property type="entry name" value="GPI TRANSAMIDASE COMPONENT PIG-S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21072:SF13">
        <property type="entry name" value="GPI TRANSAMIDASE COMPONENT PIG-S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10510">
        <property type="entry name" value="PIG-S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAG5104334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="342" mass="38291" checksum="5396C54B104D0627" modified="2022-05-25" version="1">MILRDESLILTRNAMTDPTKYSLDEENRRRFPPSSTYDVLLTVVNPDPKKLTVKWDLSNITRDYLEPFLDQLSVIANFSVKSQWLYLMPLDITPKQIPDSSELGRHFALSESILPQLITPLEKKLASQVSLHPCINLVMYSVPCDQSPLYIYTKSGDKSKSVNNVKAFLSPRWGGVVISNSPTDVCKQAIKSNYDKPAEVVPNAVTIMGVFLSQLRLLLGIPEPDDKIPGIMVTPTPGESILREWEFDALLRVRAIEQLTSAKLTLQSLAQLLEEISNIVITETVGNRIKTALDLIHLSAEKLLDGKLMEGFSLSKESFVTAEKAFTDPSLLALLYFPDDQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MSZ3</accession>
    <name>A0A8J2MSZ3_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Similar to NETO2: Neuropilin and tolloid-like protein 2 (Homo sapiens)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HICCMSTLAB_LOCUS13174</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5108312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MSZ3"/>
    <dbReference type="OrthoDB" id="9971251at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00041">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.290">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000859">
        <property type="entry name" value="CUB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002172">
        <property type="entry name" value="LDrepeatLR_classA_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035914">
        <property type="entry name" value="Sperma_CUB_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24251:SF28">
        <property type="entry name" value="NEUROPILIN AND TOLLOID-LIKE, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24251">
        <property type="entry name" value="OVOCHYMASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00431">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00042">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49854">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01180">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50068">
        <property type="entry name" value="LDLRA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="387"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="6">
        <location>
            <begin position="49"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="6">
        <location>
            <begin position="196"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="446"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="515"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="658"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="691"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="737"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="564"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="578"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="691"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="324"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="331"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAG5108312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="756" mass="85392" checksum="95D3F1A7FC61D8EC" modified="2022-05-25" version="1">MVFVVIFSLKGEKQAIRQSFGASKPSVSAGFSTEISPGFLLLTAHEAQCTLLSREDSISGCTPTKGKTNPYDQSQLNNSTINFHVVRRECTTTDKGMLIKLDFRDYFELEAPMPTNDKELECAFDYLEVRDGYYGFSTPVGNYCDKNFPPEITSRSRYLWLHFHSDDTIEYKGFKAIWSQVPRPTYLGVPAEPEPCIKYVTEQADAEINDTLIGEERKIAQKNNVPLDCLWIIRAKEKWRIQMTFEYFKLEKPNDCDANFLSIFDKKTEMNSLVKNFCGSIAETVNTKSNVMYMRFYLEIKAINSSFKSLMTAIRDKEPNVQSCEDDEYDCDDATCIAGHLRCNKRENCRLKWDEDVSICGVSYFMILINNTTLPSKSSIAFDSTRIIIILVIFSLIMFGMCFSFIFNCVRKLHRDHRIIKLKRVNTLLQEHIRMSRENRLDEIGRKATPCPLSQSQTDIRQRDSESPSLEIEPSKELVTGATLIAHDYTTKEHVLEMNYAGVEINDIHQSNNMSNATQERLQESNEEEPEMCDSSCQTRESLFDPRISDPRVSPGFSTFGYRSGSSQNGVGTSASRKPSQGQLSSQSPKQSLSSTPRTRFASEPCSICNSDSRGHVTNGIICSRHNTPIPAPPGWSFHEHESYSPPIQSTELAAESEYPSYHRYQSPKPERAPPGFKEPILSRQATIGSGERYGSLYGSGRGSSNPTNSSSQHSDTPKCPLSDPRYRAEAIIEIDQKRPFSIESTKSAPDVIATH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MT90</accession>
    <name>A0A8J2MT90_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Similar to ELAVL2: ELAV-like protein 2 (Pongo abelii)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HICCMSTLAB_LOCUS7153</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RRM elav family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5093827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MT90"/>
    <dbReference type="OrthoDB" id="266020at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008266">
        <property type="term" value="F:poly(U) RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050686">
        <property type="term" value="P:negative regulation of mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd12650">
        <property type="entry name" value="RRM1_Hu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12652">
        <property type="entry name" value="RRM2_Hu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12377">
        <property type="entry name" value="RRM3_Hu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000006">
        <property type="entry name" value="ELAV-like 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000480">
        <property type="entry name" value="Fne, isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000205">
        <property type="entry name" value="Sex lethal, isoform B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006548">
        <property type="entry name" value="ELAD_HU_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034775">
        <property type="entry name" value="Elav_RRM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002343">
        <property type="entry name" value="Hud_Sxl_RNA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01661">
        <property type="entry name" value="ELAV_HUD_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10352">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00961">
        <property type="entry name" value="HUDSXLRNA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 4" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="6">
        <location>
            <begin position="28"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="6">
        <location>
            <begin position="134"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="6">
        <location>
            <begin position="309"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="9"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAG5093827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="392" mass="42643" checksum="7180697BCFC09AD4" modified="2022-05-25" version="1">MMANGMDTVVQQNGGSNLGQSSQEESKTNLIVNYLPQTMTQEEIRSLFSSIGEVESCKLIRDKVTDSTAALSLAGDMLSPGQFSFGQSLGYGFVNYHRPEDAEKAINTLNGLRLQNKTIKVSYARPSSEAIKGANLYVSGLPKNMAQQDLENLFSPYGRIITSRILCDNITVRQFVTGGGDNLPGLSKGVGFIRFDQRVEAERAIQELNGTIPKGSTEPITVKFANNPSNNNKAIPPIAAYLAPQASRRFGGPIHHPTGRFRYIPLSPLSSTGKAMLAINKGLQRYSPLAGDLLTNSMLPGNPINGSGWCIFVYNLAPETEENVLWQLFGPFGAVQSVKVIRDLQTNKCKGFGFVTMTNYEEAVVAIQSLNGYNLGTRVLQVSFKTNKSKTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MTS4</accession>
    <name>A0A8J2MTS4_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Similar to EIF4B: Eukaryotic translation initiation factor 4B (Homo sapiens)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HICCMSTLAB_LOCUS12886</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5107723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MTS4"/>
    <dbReference type="OrthoDB" id="1748655at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23236:SF2">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23236">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4B/4H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="81"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="149"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="157"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="306"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="387"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="457"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="485"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="535"/>
            <end position="544"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAG5107723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="544" mass="60942" checksum="84AFC815EAB6821D" modified="2022-05-25" version="1">MSSRKKNKKTKGQTLALTEFLGGVPTVPIKSTNWADDVEDEHDLGSYMSRSNKEPVVLPTAPRAARGPGVDEENIPTNPPYVAYISNLPYDVVESDLADFFEGMEVSNMRLPKDSTKLRGYGYVEFADRQSLIDALSMSNTMIKTRRVRIEVSNSSNDDRRGGGRMGMGRDNRRDGYDDPERTAGDWRSKPREESSGGDDRFRSRGGFDARERRGEDREIDNKPGGWREGERSAPAFSERRGFRGGDDDKRGGGFRDEERGGSSSFGDKRGYRDDDKRGFREGGEGRRGYRDDDGRRGGFRDDESSSSTWRSEPSAQPVADNPPSAEPRTRPKLNLQPRTKPIETIAVVEPKVEEEEVKQAEAEATPAPAPVPSANIFGAAKPVDTTAREREIEARLAKVSSEKANKSDDGENKAWPKRNGEGRGDREKEKPRSVWRSDQDSNRGRPVDRRQDPPRGNTSGRYEQRGDSQGNSKGHNSRSGNYRGDGKPTDSRRHFTERERRSKDREDNVPPMPKATDEETPNFVASNKYSMLPEDVDTDNIDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MV76</accession>
    <name>A0A8J2MV76_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Mutator-like transposase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS13934</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5109298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MV76"/>
    <dbReference type="OrthoDB" id="7698403at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049012">
        <property type="entry name" value="Mutator_transp_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20700">
        <property type="entry name" value="Mutator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mutator-like transposase" evidence="1">
        <location>
            <begin position="51"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5109298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="132" mass="14850" checksum="116F98FDE5328127" modified="2022-05-25" version="1">MQKRTKKKEKCDLTSSLSDIVPGRRIIECKALLDLENIKREERRGLAFNVSNEVSTDKQHVDPTTKRQPFDINSKFAIGALHSGIGATHVNKMLASVDMPSIDSKMFKKYENEIGTAVEEVAKESCRTLIEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MVH2</accession>
    <name>A0A8J2MVH2_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Isoforms A/B/D/L (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS8895</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5097823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MVH2"/>
    <dbReference type="OrthoDB" id="3437960at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13894">
        <property type="entry name" value="zf-C2H2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="28"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="57"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5097823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="108" mass="12572" checksum="43C841129D73C569" modified="2022-05-25" version="1">MLKDISKQRVHKRRSRPLNDLSYELTNFKCPQCGKLYKAKTTLLTHMKLECGGQKIISCSICPTKFSQTIELRRHIKHLHSIYLPPKFLVFQRNPEDFVVLLAESATD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MWE7</accession>
    <name>A0A8J2MWE7_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HTH psq-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS9760</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5100687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MWE7"/>
    <dbReference type="OrthoDB" id="8195605at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007889">
        <property type="entry name" value="HTH_Psq"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05225">
        <property type="entry name" value="HTH_psq"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH psq-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5100687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="137" mass="15643" checksum="2DC824CC0DFC11B4" modified="2022-05-25" version="1">MAKAIQEVVNGTMGLKTAAKSYNVPRSTLQRRIKVFKVNSDLESSIEKRSIETVFSPTQEEELVKYLKQQESRLSGLTTKELRLLAYQLAEKNGRVKPTKDKPVLLILDGHTSHTQNLKVIDYAKKHHLRHEDQCNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MWW7</accession>
    <name>A0A8J2MWW7_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS10887</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5102182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MWW7"/>
    <dbReference type="OrthoDB" id="7675441at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="294"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="96"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="319"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5102182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="514" mass="60271" checksum="BB960BF101C36C96" modified="2022-05-25" version="1">MKKEIQEFKLVIALTLVSALVSLPTLNLLFGGLLGKLSLSEKRYQLAAHKRNISDQKFNYYNQTAQYFERESQKTKQFNTWNVDVKSIRWDNKKKAETLNSRRNKLQVLLRNEEQAYKRECDQLKARNVTKDKIPLEVLEEKLKEKRAELSLYNPNIHRRLKSYFTNPAETERVDSKLQNTAEPITRNLSRLSFDNSNYLKKRRSDSPFKNNCNTPYNYKSSLMDYSNEQNEKAFDERADAFAENRDYATSDRMDYSKKDPAFVPDRKFKERYAHRSLENTNVFDTAGHTHDIYEQQAMTDKTSVVEASDDGMHDKSNLENQEGNDSVDFISSENVDNQESNPSGEMDDSKETASDYPEQQEGPLTTITNSSDMMVLYLMYNDLQKKIEDLEVKESRACLKHLWEETLRLRDMRNRLELLREKKIYQRRDLHIDPSSKEAALNNIEKRSIQLKKREDTCADSKMYRKALMNQLADEWESLGENDKKIISQSYAEVMKNASLEIEFDIMARKGFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MX05</accession>
    <name>A0A8J2MX05_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Similar to Csrnp2: Cysteine/serine-rich nuclear protein 2 (Mus musculus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HICCMSTLAB_LOCUS11054</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AXUD1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5102516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MX05"/>
    <dbReference type="OrthoDB" id="5946974at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031972">
        <property type="entry name" value="CSRNP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023260">
        <property type="entry name" value="Cys/Ser-rich_nuc_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13580:SF9">
        <property type="entry name" value="AXIN1 UP-REGULATED 1, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13580">
        <property type="entry name" value="TGF-BETA INDUCED APOPTOSIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16019">
        <property type="entry name" value="CSRNP_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02031">
        <property type="entry name" value="CYSSERRICHNP"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0010">Activator</keyword>
    <keyword evidence="3" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Cysteine/serine-rich nuclear protein N-terminal" evidence="10">
        <location>
            <begin position="544"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="domain" description="Cysteine/serine-rich nuclear protein N-terminal" evidence="10">
        <location>
            <begin position="650"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="247"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="335"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="407"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="577"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="723"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="861"/>
            <end position="880"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1053"/>
            <end position="1074"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="247"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="344"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="447"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="503"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="513"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="609"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="619"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="731"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1074"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF16019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAG5102516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="1074" mass="120366" checksum="A13F8789D1E69C72" modified="2022-05-25" version="1" fragment="single">MKTPAIIETNMKNEAQEEANSLDTATNTAAPFNQLQLSSNDSKNISIDNNNLLMNKSTQPLTSIDQVNEVITSEDKKEDIKILDFKELNSVDSTDEFVPINNIDKTVVGLEISDEEAKQLKHDVRRLSPVLVSLRERTLGEISLTPDNNNSNKQLLDRNISQNNNSNLDKINNSSCNSNQQLEDIINFEESIGNCLLTDNCKLSLEETINQKELMVVLSRVDENNEFKIKDECGEIIKSQMIVKNNSTSVSNNNNNNNNNSDNELGNSFDMSSEYSKNDGLKINKLLEDEFDQLEQKETPVSEVITESKIIGKERIDSVDLELISMVTTDTIQNSATESGVDELEPKQESKDETQFNSIQIDVDDNLDADVDVDGLTCDEPSSLTRLTSIIQEPEEDSAESLALNTGAAGDEVRSDGSDSGLGSEIPGDPGIQPAPESDSETSFLDRIPEDILGDKEKVDENNEASLTLLPLPTIGTPQKSNLKRRMTDYAKGEQPSAKRSNNIKDKDDHHQQQQQQQQQQQQQQQPQQEDQEQQDEKQPIIAKKRNIHFDAVTVYYFPRAQGFTCVPSQASLTLLPLPTIGTPQKSNLKRRMTDYAKGEQPSAKRSNNIKDKDDHHQQQQQQQQQQQQQQQPQQEDQEQQDEKQPIIAKKRNIHFDAVTVYYFPRAQGFTCVPSQGGSTLGMSAIHTHAERFSLTEHAAEQRRLHRARLAQLRSERAATCIAEAASSSEDPSDDTDEEPSDTEDLDIDSYYFLQPVPTWQRRALLRAAGVRRIDGVEKDDCRDIRASREHCGCGCKGYCDPESCPCSRANVKCQVDRAGFPCGCSRDGCANSSESSSTDASIGISTGLTTLHYNNADTLDSTKIKKPTTPPLPSSSILPLQSTRENNLDLYGVRDSCYSNEDIANKIPQEFNQVFQGFTGPTFQSNYENYSSYELGPSTSRHHQNNYHYYQHQHQHQHQHQQQEHQLLNHQNKLKQQQQKPQFIQQFQQAFTHYNNYQDSSTAALASGDVAAGPSISCEAIQKNTHDQSKIYQQSPTEDNPPLQYTNLNSVRQSTSAAQHMGKLEPFSDLLAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MXA8</accession>
    <name>A0A8J2MXA8_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS11359</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5103137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MXA8"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035199887" evidence="1">
        <location>
            <begin position="25"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5103137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="66" mass="7656" checksum="5DD1F06EDFDF2E10" modified="2022-05-25" version="1">MRVTRYFAVKVIIVILYLLTVCHSYPSSVGIENDKNEEMKKSFKQKTKNIIFNNVNTTPHQNIKGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MXB9</accession>
    <name>A0A8J2MXB9_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Similar to DNAJC6: Putative tyrosine-protein phosphatase auxilin (Bos taurus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HICCMSTLAB_LOCUS11389</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle</location>
            <location evidence="1">Clathrin-coated vesicle</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5103197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MXB9"/>
    <dbReference type="OrthoDB" id="1717591at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030136">
        <property type="term" value="C:clathrin-coated vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030276">
        <property type="term" value="F:clathrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072318">
        <property type="term" value="P:clathrin coat disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072583">
        <property type="term" value="P:clathrin-dependent endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1110:FF:000001">
        <property type="entry name" value="cyclin-G-associated kinase isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.110:FF:000002">
        <property type="entry name" value="putative tyrosine-protein phosphatase auxilin isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014020">
        <property type="entry name" value="Tensin_C2-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029023">
        <property type="entry name" value="Tensin_phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23172">
        <property type="entry name" value="AUXILIN/CYCLIN G-ASSOCIATED KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23172:SF19">
        <property type="entry name" value="J DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10409">
        <property type="entry name" value="PTEN_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01326">
        <property type="entry name" value="PTEN_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51182">
        <property type="entry name" value="C2_TENSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51181">
        <property type="entry name" value="PPASE_TENSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosphatase tensin-type" evidence="6">
        <location>
            <begin position="197"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="domain" description="C2 tensin-type" evidence="7">
        <location>
            <begin position="376"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="5">
        <location>
            <begin position="914"/>
            <end position="980"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="101"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="548"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="693"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="739"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="111"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="129"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="568"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="587"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="601"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="693"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="754"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="783"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="818"/>
            <end position="834"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG5103197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="980" mass="108172" checksum="1944734EF72605EE" modified="2022-05-25" version="1">MSDYLKSAFGYLNGTTGTNEYVGQVLEINNVKLRVNRLIAEGNKLAIINAKYSPPTPNPRYECIYELVRGCLEPSPIKRMTTSILLERLAAIAESNNFDPREPANIEIKAPPAPPPRISPPTQPSTVIPAAASSRSTPPASSVPQQMPALHRPVPAHHPPSKVQGIPSSSLFNSLKGGAGSIFRNLKDTSSKVMQSVQQSMARTELDASYLTSRILIMPYPADGIESTYRANHIEDVRAFLQTRHPPPAKIQLYNLSRGRPNVTRLPGKHIDCTFAYSSPDSNAPLLSALYQICQDIYRYLDADFNHIVVLYCVDGCRASATIACALLLYAGVLSKPEETIALFTTRRCQPPQLQASEMRSINYMSILHSGVYPHTRPLALRSLILQPVPLFTRAKDGCRPYIEIYSNGAFVFSTKKPEYEEMKLFDMMEGKACIIIGDATVRGDVTIVVFHARQQLGRVIGIKIASLHFHTGFIPLNESALNFDKKDLDDTPEVGGQFRVMLNVMVGEDNLKPSRIPAPWEVEVSHDEDLRPDPLFGSTLEMEETLENFRTPGKSKIPPRRPSPPIIKRETSKEDTSEQIPLHQAEEEEEEDEYNDNDNDNNKQEKEKYEKLQTEESEVINSQRDILTEAVLLDFGGPSSGEPPSKISSVGPTPKLDIFSDDSKVQNDLFGNFSTFNNSVTTENTRGVNKSVSNNVFTKSSGSNSSKDQTAQKGTGDFLFDPFGGSSSNDLLSNWANTGKTSGLKTPNEDNFPRNSSVPNFGAQNKDPFANLAGSLGAGLNASWNGTPRDSNTPQSASPATAGTPIHSSPRMPNKASAPTESNNIDSSIFNNKPANKHTDVFEDLLGSQGYNFFSSRKADKDSPKTINEMRKVEAAKTMDPDVLKVSEWTEGKKGNIRGLLCSLHTVLWPEADRWQRYEMHQLVSPADVKKSYRKACLAVHPDKQSGTANENIAKLIFMELNNAWSAFENDASQQNLFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MZB4</accession>
    <name>A0A8J2MZB4_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7805 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS13855</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5109219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MZB4"/>
    <dbReference type="OrthoDB" id="10037824at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056707">
        <property type="entry name" value="DUF7805"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053207">
        <property type="entry name" value="Non-NMDA_GluR_Accessory"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47537">
        <property type="entry name" value="CUBILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47537:SF4">
        <property type="entry name" value="GH12701P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25090">
        <property type="entry name" value="DUF7805"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="497"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7805" evidence="2">
        <location>
            <begin position="294"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5109219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="552" mass="62832" checksum="5FCF2ED11A7DA13E" modified="2022-05-25" version="1">MLPLSDCNDISWYYYMLQLLLLLLVLSNYNYCYCFIYRLNFSEKERLRYMERTGDSITPIGAGPHSNTSLLARYCKDRVPKTCDHAILQNTSRPCSLVEGFISSGNSLTIEIRMIESTALRPVNFRALYEFVDLHHDGEPYGNGPCSRVFYSRNRDQYPDRKFQAPRNIFLYGRGGTQNLSCVYRFEGEQDEVVKLRFNKLLNGNRTCRSVSSVDYNRFLCIGSSNFSLKVMELPWSNAAPIQRDCLCSNRSLPINIKSLSHVVEVHFTIQSMTALDDYNNLFFEGVWDFIKAVPCLQKRRVRGPSGEIKYELPLTNEDQKNCKHHPWLIDPGPGQYLYLETHGVVMNSNSSSNKCLTSNRIIVHTGGNVNVSVCPKPESDSRHKVVKVFSKGWSVEHKTMMLAPRFDPMRTIAVEFIMNEADSYTVTWLELTKKWPSSIMSIAEPGESLPRDCEQRCPELNACINTSLWCDGTSHCPSGYDEALTHCSMLLRLPPLHLAIGASIVVTIIGTTCIIFWRCIRRKANRSISQHRLKSISSETAIIGDGKEVIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MZL0</accession>
    <name>A0A8J2MZL0_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Coronin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HICCMSTLAB_LOCUS12887</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the WD repeat coronin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5107725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MZL0"/>
    <dbReference type="OrthoDB" id="1850764at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000502">
        <property type="entry name" value="Coronin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015505">
        <property type="entry name" value="Coronin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015048">
        <property type="entry name" value="DUF1899"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10856">
        <property type="entry name" value="CORONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10856:SF44">
        <property type="entry name" value="CORONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08953">
        <property type="entry name" value="DUF1899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16300">
        <property type="entry name" value="WD40_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01166">
        <property type="entry name" value="DUF1899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01167">
        <property type="entry name" value="DUF1900"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="4 8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 6 7" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="DUF1899" evidence="9">
        <location>
            <begin position="52"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="125"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="175"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="218"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="550"/>
            <end position="577"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU280818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAG5107725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="577" mass="65010" checksum="07737B8E0A9110DC" modified="2022-05-25" version="1">MGHSVRDREMIKVKEEFESKLSKEANNDQHNLLSNMVDARACYKPSERSWFRGVRSSKFRHVYGLPAKRDKCYDNIKITKNAHDSQFCAVNPKFLAIVTEVAGGGAFLVIPLDNTGRLDFNANRVTGHTGPVLDIKWNPFNDNVIASCSDDCTVKLWHIPDGGLSRNLNEWLVELQGHKRRVAYIEWHPVADNILFSAGFDHLVIVWDINRGEAINIIDRHPDVIYSMSLNRDGSLLATTCKDKKLRVFEPRSGIVISEGICHAGTKASKVVFLGGSGRLLTTGFSRHSDRQYAVWSQHDLSSPLTCETIDSSSGIVFPFCDNDTNMVYLAGKGDGNIRYYEVVNEAPWLHYLSQFISGNPQRGLGVMPKRGINTSTCEVFRFFKLHATRGMCEPISMIVPRKSDQFQEDLYPDTVGTIPSLSAKDWISGMNSPPILISLKTGGGITTHKPRVYKPAQLTPATDTNTKKKFAFLSTETIPDYRSIDLDISEKSQKTSSNQSTKIHQLQQRFGHVTIQNNNSSDNKISESVDVPNNEAELRLAYVRQMDELRLVKRQLANSQLRVKELEEQLRKLQNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MZR5</accession>
    <name>A0A8J2MZR5_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Similar to Msh6: Probable DNA mismatch repair protein Msh6 (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HICCMSTLAB_LOCUS13024</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA mismatch repair MutS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5108011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="121051at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032301">
        <property type="term" value="C:MutSalpha complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1420.10:FF:000005">
        <property type="entry name" value="DNA mismatch repair protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1170.10:FF:000002">
        <property type="entry name" value="DNA mismatch repair protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1420.10">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1170.10">
        <property type="entry name" value="DNA repair protein MutS, domain I"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.110">
        <property type="entry name" value="MutS, connector domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007695">
        <property type="entry name" value="DNA_mismatch_repair_MutS-lik_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000432">
        <property type="entry name" value="DNA_mismatch_repair_MutS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007861">
        <property type="entry name" value="DNA_mismatch_repair_MutS_clamp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007696">
        <property type="entry name" value="DNA_mismatch_repair_MutS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016151">
        <property type="entry name" value="DNA_mismatch_repair_MutS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036187">
        <property type="entry name" value="DNA_mismatch_repair_MutS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007860">
        <property type="entry name" value="DNA_mmatch_repair_MutS_con_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045076">
        <property type="entry name" value="MutS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036678">
        <property type="entry name" value="MutS_con_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361:SF148">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MSH6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01624">
        <property type="entry name" value="MutS_I"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05188">
        <property type="entry name" value="MutS_II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05192">
        <property type="entry name" value="MutS_III"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05190">
        <property type="entry name" value="MutS_IV"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00488">
        <property type="entry name" value="MutS_V"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00534">
        <property type="entry name" value="MUTSac"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00533">
        <property type="entry name" value="MUTSd"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55271">
        <property type="entry name" value="DNA repair protein MutS, domain I"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53150">
        <property type="entry name" value="DNA repair protein MutS, domain II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48334">
        <property type="entry name" value="DNA repair protein MutS, domain III"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00486">
        <property type="entry name" value="DNA_MISMATCH_REPAIR_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA mismatch repair proteins mutS family" evidence="7">
        <location>
            <begin position="984"/>
            <end position="1000"/>
        </location>
    </feature>
    <feature type="domain" description="DNA mismatch repair proteins mutS family" evidence="7">
        <location>
            <begin position="2148"/>
            <end position="2164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1132"/>
            <end position="1339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="35"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="72"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="144"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="160"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1133"/>
            <end position="1152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="1217"/>
            <end position="1229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1259"/>
            <end position="1273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1274"/>
            <end position="1285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="1301"/>
            <end position="1312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG5108011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="2295" mass="260140" checksum="BE21096E63E5C057" modified="2022-05-25" version="1">MSKRCLRSNTSIDDPTSPKVQKKIKKSTTKDVSDSKLSAIKSAKLKPSTAKKATVNKKEEKENVVTSKRTRQVKEKPQRKDNLNDKVLTVKRKRKIIIPSDDSGDDSDEYKPNNEAADSDDSGSLDVVSELDSSLDSDFDNKPTLKNNRPINTTKKQKKSRSDSKREEKKSDESVKSVQLEKVNLSSGLVSRQKSWPHLNYSFMHPHELRDANERRPTHPQYDPKTLHVPKKFLDKQTPAMRQWWLHKSQHWDCVLFFRIGNYYVLHHMDALTGVNELGLSLVRRVSFPYVWFFEKHYARYLRILIDKGYKVARIEQTENQAMMEERCEKLKSRATKFDKIMRRELCQVVTRGTRVPTVLDIENFSSHSNYLMTLVEEQNLSQFPSYGICFIDTSIGVFHLGQFDDDHQNSRLLTLLSHYTPAHIIYGKGNLSQTTMKILNTHLPITTIKEALLMESQFWSVKKVIDRLKDGDYFKYESDKFSWPEGLKPFINFHDANNVKLVDDKKLAMHALGGCLYILTEYLLDQQLLALKKFQTYIPPDMNVVDGKRAGSSPSLLTTLDFCCTDFGKRLLKEWVCQPACNSRTIRARQDAVGELRDLKSICIKARRQLSGLQDLERLITKIHAYGNSAKVKNHPDARAISSDWMIYNKRRITDLITCLKGFKQAVGIMKIFGSLKSDLIIQTTQVKPRGEFPDFTETLSHFESGFDETLALKHGCIMPKKGMDLEYDQVIVELEQVKNDADEYLKSQSQKYETECKYISTSESTYEIEISEKIVSNVIDGYDFKKTRKGFKRYWNEETKKLQERKTAAEARHDMLLKDSDRRIFAKFSEDYDMWATAVYKVAVLDVLISLAEYSRIGDKCAPEINDTDEVMLDIQEGIHPFITSENFVPNNTSLAINDYGPLVILTGPNMGGKSTIMRQAGLLSIMAHIGCHIPAQSCKLSLIDRVFTRLGANDDMRTGRSTFLVELSEAATFVLHATKNSLVLVDELGRGTSTHDGTAIAAAILKALSKLECRTLFSTHYHMLVSEFKDNPAVSPAHMACQVESEETDATQETVTFLYKLTKGPCPKSYGFNAARIAGIKSHITKRANELAKKLEDAGNRRNLFISLCSVNRNDVKNLIGHKRNLRSRTRTEDLESPKKVPKKDEKKVTKTTTRPKLQSSKPATPKRQPAKSKAKAKPQTQPKKAIINGKENKETTATPKRKREVKKPKVEELYSDDDDDEEEEEKTPVKRKRRKIVVPSDDSGDDSDEYKPSDASDSDASISSAAASSEVDTSLNNTADTVSDDEPPPKREQKPRNPGRGKKWYPNKKKVEDDDESGKSFQLAKAKLQSGPVSGAESWPHLKYPFLQPENILDAEKRRPDHPEYNPKTLYVPQEFLDKQTPSMRQWWTLKSQHFDCVLFHKIGKFYGLYHMDAVSGVNALGLNFIQRDFAYTGCFEVNYSRLFKTFVEKGYKVARVEQTETPQMMAKRCDKSKSKASKFDKLVRREVCQISTRGTRVSTVLDIENFSSHSNYLLSLVEDHSNKLPTYGICFIDTSIGIFHLGQFKDDCHNSRLLTLLSHYTPAHVVYGKGNLSPVTMKILNTHLPVTTLKEALLKDQFWSVKVILDKLKDGHYFKYESDEFSWPEGLKPFINYHDNNKTVNPVNDKKLAINALGGCVSVLTECVLDEQLLALKKFQTYIPPDMNVVDGKRVGPLVNMVIDAATIENLNILGKSPSLLTTLDYCCTDFGKRLLKEWVCRPACNRDIITARIDAVSELRDLKRICLDAKKQLSSLPDLERLLTTIHGHGNASKVKNHPDSRAIMCEWMTYNKRKITDLVTCINGFKQVVEIIKLFDSLVSDLIVQTTQVEPKGEFPDMTEALNHFDARFDSELALKQGCIIPKKGMDLEYDQVIVELEQVKNDADEYLKSQSEYFGTEIEYIGGGDNPYQLEVPESCASKVTPDYELEHKRKGFKRYSTEQTIKLQKRQTAAEEHHDKVRKDSDRRTFAKFSENYDMWATAVYKVAVLDVLISLAEYSRIGDKCAPEINDTDEVMLDIQEGIHPFITSENFVPNNTSLAINGYGPLVILTGPNMGGKSTIMRQVGLLSIMAHIGCHIPAQSCKLSLIDRVFTRLGANDDMRTGRSTFLVELSEAATFVLHATKNSLVLVDELGRGTSTHDGTAIAAAILKALSKLECRTLFSTHYHMLVSEFKDNPAVSPAHMACQVESEETDATQETVTFLYKLTKGPCPKSYGFNAARIAGIKSHITRRANELAKDVEDAGNRRNLFISLCSVNRHNIKEILATLDSFSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-10-16" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>S6CWK6</accession>
    <name>S6CWK6_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Cc_bv6.23_32.23</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">bv6-23</name>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS6202</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Philos. Trans. R. Soc. Lond., B, Biol. Sci." volume="368" first="20130047" last="20130047">
            <title>Functional endogenous viral elements in the genome of the parasitoid wasp Cotesia congregata: insights into the evolutionary dynamics of bracoviruses.</title>
            <authorList>
                <person name="Bezier A."/>
                <person name="Louis F."/>
                <person name="Jancek S."/>
                <person name="Periquet G."/>
                <person name="Theze J."/>
                <person name="Gyapay G."/>
                <person name="Musset K."/>
                <person name="Lesobre J."/>
                <person name="Lenoble P."/>
                <person name="Dupuy C."/>
                <person name="Gundersen-Rindal D."/>
                <person name="Herniou E.A.Drezen.J.M."/>
            </authorList>
            <dbReference type="PubMed" id="23938757"/>
            <dbReference type="DOI" id="10.1098/rstb.2013.0047"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5092533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="HF586473">
        <property type="protein sequence ID" value="CCQ71255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S6CWK6"/>
    <dbReference type="OrthoDB" id="10299939at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5092533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCQ71255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="98" mass="11827" checksum="A8C1670972668E13" modified="2013-10-16" version="1">MPCPNCKNNVTTHKNIYVVPREWQTHNFLECALWKIHSNHYRTYKTTKSFRVYADGITARLENYSNYLWLRKTYDFAEKPDPKKYFSAYVACIYCNNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-10-16" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>S6D4N9</accession>
    <name>S6D4N9_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cc_ben.9_23.1b</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">ben-9</name>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS6071</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Philos. Trans. R. Soc. Lond., B, Biol. Sci." volume="368" first="20130047" last="20130047">
            <title>Functional endogenous viral elements in the genome of the parasitoid wasp Cotesia congregata: insights into the evolutionary dynamics of bracoviruses.</title>
            <authorList>
                <person name="Bezier A."/>
                <person name="Louis F."/>
                <person name="Jancek S."/>
                <person name="Periquet G."/>
                <person name="Theze J."/>
                <person name="Gyapay G."/>
                <person name="Musset K."/>
                <person name="Lesobre J."/>
                <person name="Lenoble P."/>
                <person name="Dupuy C."/>
                <person name="Gundersen-Rindal D."/>
                <person name="Herniou E.A.Drezen.J.M."/>
            </authorList>
            <dbReference type="PubMed" id="23938757"/>
            <dbReference type="DOI" id="10.1098/rstb.2013.0047"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5092345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="HF586472">
        <property type="protein sequence ID" value="CCQ71095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S6D4N9"/>
    <dbReference type="OrthoDB" id="10071220at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018379">
        <property type="entry name" value="BEN_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10523">
        <property type="entry name" value="BEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51457">
        <property type="entry name" value="BEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BEN" evidence="2">
        <location>
            <begin position="772"/>
            <end position="876"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="110"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="369"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="418"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="554"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="685"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="156"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="183"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="207"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="433"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="452"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="479"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="575"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="595"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="696"/>
            <end position="710"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5092345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCQ71095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="882" mass="100011" checksum="812F4627841EC691" modified="2013-10-16" version="1">MKRHNNYKRAFYVVQFIELPFEGIDDYVCVPYTWLIVRKATDQKAVVAYPKDEDPFNTRDRVKRKERHNHEWRFYMAIVKYESDSYGDAEYWIATRNDYGPLVEKELKTTDSEPKFPLNKKLRVANRNHSSKLNDNPRKPLPRISIKRPALPEPNKQLDGKRIKLDDAAQSSSAVVTDANAEPGSSRQEQSIIAQDNQPMESAQTETTASDSNGTSSSSQRKDENLQESLPIQEQQELGMPYIDVATSDTPALVIDEDEEVQTASIVEQQVPSNQAISQFTEQPEPIREPKIPVAPSIEMTNNSQGSRMDDALNNGPTSNRLLNSPKISAQLYSQMIEARRLIPTQKPVEKNLRPMNIARNLAITEHNSSNLMDQTGSLSTRSVPIQQQHHTSSYQNQNLPTNQSNFEQDLLSKSAETNNYEQRPNSRPIRMSTPSIGQNSINSSTPLYQISELPQLRQSQPSQQDSQRQPQKPKRRIGTSTKPQNNRQTPTFQVTKETLSPILTKVLNSLRQALSTTHNQYLLNEQQFQGNHSERAPVDENHLSQIDNTLQTDERMEEETPSAHHGANSDSDTITDHEVTSDHEMSADEAPVERTNNFYGPGISSGSSSAHRPIAAQNSTNHQTHSKVVLEQQMLDNFATLFTQMGSTLRYTTDMYNTLRSSILDTAQTYKKLLGAVEEFNSAQKLASNSSSSSNRREEVSQFPEERHMKISARANSSYTNRYNEEVANNPPKKKHNSWRFVLPSEYDPRDTRWTLKYRTNLPGLVELMPQSDVYVSYGDLKYCQQVSKDCKSLALRLLPAVFNSKALSVCLSITERAQASDNVRSNARPELDDHACSALLNFVLEHGLQRGWNTDLQPILSTLHSKIQEIRFRYGVMVEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>S6D9M1</accession>
    <name>S6D9M1_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cc_ptp.b_1.1</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">Protein tyrosine phosphatase PTPB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ptpb</name>
        <name evidence="4" type="ORF">HICCMSTLAB_LOCUS7324</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="Philos. Trans. R. Soc. Lond., B, Biol. Sci." volume="368" first="20130047" last="20130047">
            <title>Functional endogenous viral elements in the genome of the parasitoid wasp Cotesia congregata: insights into the evolutionary dynamics of bracoviruses.</title>
            <authorList>
                <person name="Bezier A."/>
                <person name="Louis F."/>
                <person name="Jancek S."/>
                <person name="Periquet G."/>
                <person name="Theze J."/>
                <person name="Gyapay G."/>
                <person name="Musset K."/>
                <person name="Lesobre J."/>
                <person name="Lenoble P."/>
                <person name="Dupuy C."/>
                <person name="Gundersen-Rindal D."/>
                <person name="Herniou E.A.Drezen.J.M."/>
            </authorList>
            <dbReference type="PubMed" id="23938757"/>
            <dbReference type="DOI" id="10.1098/rstb.2013.0047"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5093998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="HF586476">
        <property type="protein sequence ID" value="CCQ71314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S6D9M1"/>
    <dbReference type="OrthoDB" id="10051650at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009653">
        <property type="term" value="P:anatomical structure morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048666">
        <property type="term" value="P:neuron development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00047">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050348">
        <property type="entry name" value="Protein-Tyr_Phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000242">
        <property type="entry name" value="PTP_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19134:SF534">
        <property type="entry name" value="LD27988P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19134">
        <property type="entry name" value="RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00102">
        <property type="entry name" value="Y_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00700">
        <property type="entry name" value="PRTYPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00194">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50055">
        <property type="entry name" value="TYR_PHOSPHATASE_PTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="278"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="2">
        <location>
            <begin position="28"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="3">
        <location>
            <begin position="200"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG5093998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCQ71314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="299" mass="34454" checksum="87316600472317B2" modified="2016-04-13" version="1">MGAKLTKKNSFAKNCEQLIEESRLAHILKEEHHQIVQENVPYSCYEVLKLKNWSKCRYWNTSIFDRNRVILKTEDGGSDFINASYVDGHNAKGRFICTQAPLEETANDFWQMIFSHQVRVIVMLTRIMEKGREACYPYWNPKKRGKAVHGKFTIKTLKIKSFRYYAVTNLQVTDNTGASLDVQHFAYTDWPHNSLPRNPSKFLDFVLAVREAQLTADVDNKGKNIPPIVVHCSAGLNRTGAFCAIDVSLSLYNERATISLSSIVRNLRKQRHNCLSLPQYYVFCYLIVLIYAKLVADKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2E4I5</accession>
    <name>A0A8J2E4I5_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BEN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS186</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030000989">
        <property type="protein sequence ID" value="CAG5072758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2E4I5"/>
    <dbReference type="OrthoDB" id="7701457at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2590">
        <property type="entry name" value="BEN domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018379">
        <property type="entry name" value="BEN_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10523">
        <property type="entry name" value="BEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01025">
        <property type="entry name" value="BEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51457">
        <property type="entry name" value="BEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BEN" evidence="2">
        <location>
            <begin position="53"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5072758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="169" mass="18864" checksum="3CC8C71290B3A9D1" modified="2022-05-25" version="1">METRPGSSNVTVSSGLSSNSRQPSNISVTQTKTPETVYARPISLNEIEIGRSESNVIISTESWDTAKVKNSYTSMACSLLLAVYDLRTLLQSNVNGGKCKVTKKKKPEQHKTLDANLLRAIKYTVREKFPNQYKEAALNTAITNKLNALRTKNRVQINRENNTRSEESD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2E4Y6</accession>
    <name>A0A8J2E4Y6_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS459</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001114">
        <property type="protein sequence ID" value="CAG5073516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2E4Y6"/>
    <dbReference type="OrthoDB" id="7701443at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.31.10">
        <property type="entry name" value="Transcriptional Coactivator Pc4, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009044">
        <property type="entry name" value="ssDNA-bd_transcriptional_reg"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54447">
        <property type="entry name" value="ssDNA-binding transcriptional regulator domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5073516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="144" mass="16433" checksum="9F1BDF7C59DC6492" modified="2022-05-25" version="1">MEGSNIMVSEYRLLMITKCNTKKAGQMIRDLFRLVLGEEKLSRMVPLKQKEGRELIPEDISEAIFQYVNANVSKGHEVNVDEFQNIVEAIRNYGGKIFVDICETTTNQESEIKATSKEISLTVDNFRKLKMVITEIEEAITEAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2E5P8</accession>
    <name>A0A8J2E5P8_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS897</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001114">
        <property type="protein sequence ID" value="CAG5074125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2E5P8"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5074125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="108" mass="12344" checksum="28A80ED39CF990C0" modified="2022-05-25" version="1">MKKANKVSEDRKNFRNLPILDKKNYTQVCEAIKTGKLSKDVMVKVPFYCFSSLRHHDHGKLCTYLSLPTIIDYDCLSMLHVSIALDDQAMVDQLLALKVNLQATTKEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2ECB0</accession>
    <name>A0A8J2ECB0_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similar to ZBED1: E3 SUMO-protein ligase ZBED1 (Homo sapiens)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS1381</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001116">
        <property type="protein sequence ID" value="CAG5075227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2ECB0"/>
    <dbReference type="OrthoDB" id="7696101at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008906">
        <property type="entry name" value="HATC_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052717">
        <property type="entry name" value="Vacuolar_transposase_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46169">
        <property type="entry name" value="DNA REPLICATION-RELATED ELEMENT FACTOR, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46169:SF15">
        <property type="entry name" value="INNER CENTROMERE PROTEIN A-LIKE ISOFORM X1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05699">
        <property type="entry name" value="Dimer_Tnp_hAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HAT C-terminal dimerisation" evidence="1">
        <location>
            <begin position="253"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5075227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="312" mass="35356" checksum="BDCAD13F68EE9067" modified="2022-05-25" version="1">MTSGSFVGASAGRLRYTRCSGFILASWIESLNQRSTLVPLPRALASVQVQHFDLFKASKLAGVQRLQCYLQLEDYVYPVTSKCASPLPLLSHEEIAILKDIVDVMQIIAKVITEISGDTYLTCSIIIPIVACMKNTIRQRVPTTSIGAEFKEAIIYQIEKRFNDIESFEILCISTILDPRFKKIHFQKAMSASHAIDTINRKMKSAVSPDPIQLQLQLRTENNNLKNDIWNYHDDLVKKTGAAKNSTDGLTFELKQYLSQPVISRTEDPLKHWNLLQPSYPNLYNVAIEYLCVVGTSVPSERLLSFFDDWKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2EHQ4</accession>
    <name>A0A8J2EHQ4_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Class 6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HICCMSTLAB_LOCUS261</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the POU transcription factor family. Class-6 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001114">
        <property type="protein sequence ID" value="CAG5073284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2EHQ4"/>
    <dbReference type="OrthoDB" id="10066259at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000051">
        <property type="entry name" value="POU domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="entry name" value="lambda repressor-like DNA-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013847">
        <property type="entry name" value="POU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000327">
        <property type="entry name" value="POU_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050255">
        <property type="entry name" value="POU_domain_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11636">
        <property type="entry name" value="POU DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11636:SF5">
        <property type="entry name" value="POU DOMAIN MOTIF 3, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00157">
        <property type="entry name" value="Pou"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00028">
        <property type="entry name" value="POUDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00352">
        <property type="entry name" value="POU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="lambda repressor-like DNA-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00035">
        <property type="entry name" value="POU_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51179">
        <property type="entry name" value="POU_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 8 9" id="KW-0371">Homeobox</keyword>
    <keyword evidence="6 8 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="POU-specific" evidence="12">
        <location>
            <begin position="401"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="domain" description="Homeobox" evidence="11">
        <location>
            <begin position="526"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="8">
        <location>
            <begin position="528"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="122"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="254"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="333"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="254"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="363"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00061425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAG5073284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="592" mass="64298" checksum="4DE81220913EF2B5" modified="2022-05-25" version="1">MAQASRYLLTNLESDRSSTGSPEPASGVLHEHHMLMEGLKNSRKRRRSTSPENMTHSKFPRSDSHLNGTMAGMVTLQNLQNLANLQQNLPQVTSLAAGLQAGMSSGLSTNQMINTPLNLTVSASGGTAPTPSSTTSSPHLLPSSSAPMATLPQLLSQHQPVSMPQFILTSGQLVQGIQGAQLFIPTSQGKHDPYFQITLTQIIMLHWLVTQTILTIPVNHVTNNQMVNLALSNGQVVSTTLANLQSIAQPQNLMNTPASNGNNNCSSGFKTVPTSQSMASGLGLNPASLPHLLGNNSASQQLLNAMQPQQLLQAAQAAQAQAQAAQAAQAAQASQQPLLATSPQHQHTHRHTSHLNHYQQQPSDKHHRERLEQSSPLNNPAVSAASALNRLAATNGEITITTTHGPDEIKEFAKAFKLRRLSLGLTQTQVGQALSITEGPAYSQSAICSALATQMYAASQIASQQQAMFEKLDITPKSAQKIKPVLARWMKEAEESCQNFSESSVYDYRYKSGANNLTEFIGVEPSKKRKRRTSFTPQALELLNAHFDKNTHPTGNEITTLAQQLGYEREVIRIWFCNKRQALKNTVRMMSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2EI48</accession>
    <name>A0A8J2EI48_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Pyridoxal phosphate homeostasis protein</fullName>
            <shortName evidence="2">PLP homeostasis protein</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HICCMSTLAB_LOCUS2203</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="2">Pyridoxal 5'-phosphate (PLP)-binding protein, which may be involved in intracellular homeostatic regulation of pyridoxal 5'-phosphate (PLP), the active form of vitamin B6.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001117">
        <property type="protein sequence ID" value="CAG5076496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2EI48"/>
    <dbReference type="OrthoDB" id="10264196at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06822">
        <property type="entry name" value="PLPDE_III_YBL036c_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.10">
        <property type="entry name" value="Alanine racemase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02087">
        <property type="entry name" value="PLP_homeostasis"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001608">
        <property type="entry name" value="Ala_racemase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029066">
        <property type="entry name" value="PLP-binding_barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011078">
        <property type="entry name" value="PyrdxlP_homeostasis"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10146">
        <property type="entry name" value="PROLINE SYNTHETASE CO-TRANSCRIBED BACTERIAL HOMOLOG PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10146:SF14">
        <property type="entry name" value="PYRIDOXAL PHOSPHATE HOMEOSTASIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01168">
        <property type="entry name" value="Ala_racemase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004848">
        <property type="entry name" value="YBL036c_PLPDEIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51419">
        <property type="entry name" value="PLP-binding barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01211">
        <property type="entry name" value="UPF0001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2 3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alanine racemase N-terminal" evidence="5">
        <location>
            <begin position="36"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="2 3">
        <location>
            <position position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR004848-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAG5076496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="231" mass="25998" checksum="AF36F6DC78C88460" modified="2022-05-25" version="1">MKIKMVDIAGNLSFVRDKISQACSRRPSELGNVIPRLVAVSKTKPPNLVIDAYDAGQQHFGENYVNELIEKAGHPDILKRNIRWHFIGHLQRNKVNKVLAVPNLWVVETVDSNKLATALDIAWPKFRRSDDSKLNIMVQVNTSKEEENCKNLNFLGIMTIGAYGYDPASGPNPDFLSLRQCREEICKELSLDKEQVELSMGMSTDFEHAIELGSTNVRVGSLLFGERPPKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2EJ91</accession>
    <name>A0A8J2EJ91_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Quinone] (Drosophila pseudoobscura pseudoobscura)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HICCMSTLAB_LOCUS1167</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001116">
        <property type="protein sequence ID" value="CAG5074956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2EJ91"/>
    <dbReference type="OrthoDB" id="269227at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF217">
        <property type="entry name" value="GLUCOSE DEHYDROGENASE [FAD, QUINONE]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00623">
        <property type="entry name" value="GMC_OXRED_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00624">
        <property type="entry name" value="GMC_OXRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="4">
        <location>
            <begin position="136"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="5">
        <location>
            <begin position="311"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="138"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="142"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="275"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS00623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAG5074956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="600" mass="66087" checksum="D900EFD7EE9C5126" modified="2022-05-25" version="1">MSCDCPLGAPTGPSLASACGGPSFMLFMGLLEVFLRSQCDLEDPCNRPKSREQINSSYDFIVIGGGSAGATVAGRLAENDKFSVLLIEAGLDEPTTTQIPSFFFNFLGSSIDWQYSTEPEPEACLNKEGRCYWPRGKVLGGTSVMNGMTYMRGSKKDYDNWARLGNSGWSYQEVLPYFIYSEDNQQINQMDYGYHGSGGPLTVTQFPYHPPLSRALIEAGKELGYDNVDLNGRTHTGFAIAQTTSRNGSRLSTARAFIRPVKNRSNLHILLNATVTRIIFNNNRQAIGVEYSKSQQLRRVSVRKEVIVSGGAVNSPQILLNSGIGPREELSSVGVPIIHHLPGVGKNLHNHVAYALVFKINDTDTTPLNWATAMEYLLFRDGLMSGTGISEVTAMINTKYANPEDDHPDIQLIFGGYLADCAETGTVGEKKGNRRSILMIPTLLHPKSRGELKLKDSDPLSKPMIYPRYLTEPEDVKRLVEGIKFCVRLAETRVLSRYGFELDRTPVKGCENLRFGCDAYWECAIKRDTAPENHQAGSCKMGADDDPLAVVDNQLRVRGVRGVRVADTSVMPAVTSGNTNAPAIMIGERAADFIKKTWIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2EJV0</accession>
    <name>A0A8J2EJV0_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similar to Meioc: Meiosis-specific coiled-coil domain-containing protein MEIOC (Mus musculus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS1380</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001116">
        <property type="protein sequence ID" value="CAG5075226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2EJV0"/>
    <dbReference type="OrthoDB" id="26491at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007144">
        <property type="term" value="P:female meiosis I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007141">
        <property type="term" value="P:male meiosis I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048255">
        <property type="term" value="P:mRNA stabilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027963">
        <property type="entry name" value="MEIOC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33861:SF5">
        <property type="entry name" value="GAMMA-TUBULIN COMPLEX COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33861">
        <property type="entry name" value="PROTEIN CBG18333"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15189">
        <property type="entry name" value="MEIOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="186"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="190"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5075226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="859" mass="97841" checksum="6638B3296DF2BDA1" modified="2022-05-25" version="1">MALSKVQNFTSILGNNSNEKIKSDINMYDTSGNNCISDTNRCREYNPWNYDLMSRNTIHKVEDEETQDLNNSMVNDLVSKVLADDPATDQPIYNYNLNQYHDLDLLKPQSQSSYFKNGSSNSNYESQYRYIQNQPENRDILDIYSNLESLCINDLVSQDTFNVNSQFKNVTAYNDDFISSKFTASGLQVQHQPQPQSQSQPQPQYQPPSQSHQTPWTDFEDPFDSYQQFPCHDLNFNTISPSASTLHDHQDLSHPASGASLINIQDFNNTNQSYHRPGSAMTDFSTDSGFLSNSPLQTQHLSPDFNHFSSYRYDDPINSQNLATSSLMSNSGLKNFDKLDYDYKTRTDYINNYHDNDHEFKSMAVNQKIDDQLVKMFATSTIKIKDHQNHGLNHQNFSNHHNQLPSHQNQLPNHQNYLNPGQNCYPYRLTRINGQGTTQPITMDQLNKYNYPLNIEQNYPQRYTANNTDLKSSSTINNTLSMINNNSYQNNVSKTLNPTVNNHNYDNRNDSAVGSINYSNLAAQLRNVDPNLLHSIIKQQQQQQQQQQQQQQQQQQQQQQQSQPMRMPDMLMNARLIRANTSVSGSAGASAPSIYPSMLSVPLVQPINGIINAGIGLRGIKARRAGASSVLHLRLEQTFDQFKQLEKERKKCEAGLAAHFPGKRVTSANNIPVPRLQGNPSRADRLIIDHLREHARVITLIAKMEHLRGVTMNERVHKAMEFWLESIKFVQECRKKEITHATKRQKENPHCSPIHDDKDIIILAESIRELTRAARLARSAMFNAMQSTLLQNKDLEKKIIETSTDVILTVITKESVASLSSSSASASPQTDVLINSNLKVRHFEFSSTILLSTDLLKQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2EP34</accession>
    <name>A0A8J2EP34_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Similar to kcnq1: Potassium voltage-gated channel subfamily KQT member 1 (Xenopus laevis)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HICCMSTLAB_LOCUS2179</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>K(+)(in) = K(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29463"/>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001117">
        <property type="protein sequence ID" value="CAG5076406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2EP34"/>
    <dbReference type="OrthoDB" id="8879391at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008076">
        <property type="term" value="C:voltage-gated potassium channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005249">
        <property type="term" value="F:voltage-gated potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1910">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003937">
        <property type="entry name" value="K_chnl_volt-dep_KCNQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013821">
        <property type="entry name" value="K_chnl_volt-dep_KCNQ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005827">
        <property type="entry name" value="K_chnl_volt-dep_KCQN1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47735:SF14">
        <property type="entry name" value="POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY KQT MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47735">
        <property type="entry name" value="POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY KQT MEMBER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03520">
        <property type="entry name" value="KCNQ_channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01460">
        <property type="entry name" value="KCNQ1CHANNEL"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0407">Ion channel</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0630">Potassium</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Potassium channel voltage dependent KCNQ C-terminal" evidence="9">
        <location>
            <begin position="170"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="57"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="70"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00034430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAG5076406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="302" mass="33875" checksum="A13684E38CC7E8A7" modified="2022-05-25" version="1" fragment="single">GILGSGFALKVQQKQRQKHFNRQIPAAAMLIQCLWRCYAADKAINSVATWNIYIKDPAPGGQPSTPLGKVAKKASVLKRRKSRNRMEMQGSQTSGLPSIMTPSSGPGTGTGTQTDSQRIDNEGDVVFYMEEPKAGTPNRARRDNRGSLFTSQTSSVTEAASDEIDIDIEEPQRVTTLTEAHRNAIRAIRKIKYFVARRKFQQARKPYDVRDVIEQYSQGHLNMMVRIKELQRRLDQTLGKPGSYLAGIDRAGNVKPMTIGARLYRVEQQLAVMDKKLDQLVYVLNAMAQKQQIPLRSIEDEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2EP58</accession>
    <name>A0A8J2EP58_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS2239</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001117">
        <property type="protein sequence ID" value="CAG5076639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2EP58"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5076639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="80" mass="9279" checksum="1CA9130EB49ECD4D" modified="2022-05-25" version="1">MLWLLFLERTFRPLLSKKEGLSRHCNWPCMQAWKILAASPNYLHHFLLRLLASFSTASLLLPLSRARTLIKSSFRPLAAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2EP64</accession>
    <name>A0A8J2EP64_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Similar to XPO7: Exportin-7 (Gallus gallus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HICCMSTLAB_LOCUS2254</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the exportin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001117">
        <property type="protein sequence ID" value="CAG5076699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2EP64"/>
    <dbReference type="OrthoDB" id="244158at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005049">
        <property type="term" value="F:nuclear export signal receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006611">
        <property type="term" value="P:protein export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000554">
        <property type="entry name" value="Exportin-7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000042">
        <property type="entry name" value="exportin-7 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001494">
        <property type="entry name" value="Importin-beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057947">
        <property type="entry name" value="TPR_XPO7/RBP17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044189">
        <property type="entry name" value="XPO4/7-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12596">
        <property type="entry name" value="EXPORTIN 4,7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12596:SF2">
        <property type="entry name" value="EXPORTIN-7 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03810">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25795">
        <property type="entry name" value="TPR_XPO7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00913">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50166">
        <property type="entry name" value="IMPORTIN_B_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Importin N-terminal" evidence="8">
        <location>
            <begin position="26"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAG5076699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="1106" mass="125256" checksum="9DC3D0AD796CB1F2" modified="2022-05-25" version="1">MQEVQQLELLCKQLYESQDAAHRAEAEKALVGFQNAPDTLTKCQLLLERGDSAYAQLLAATTLTKLVSRSAQGLSLQQRLDIRNYVLNYLATRPKLPSFVIQALVTLFARISKLGWFDSDKDDYVFRNVVGDISKFLQGSVEHCMIGVQLLSQLTCEMNQISEADANRSLTKHRKIASSFRDTQLFEIFRLSCSLLGTARENCKNLNFNDESQHGLMTQLLRLARNCLTFDFIGTSTDESSDDLCTVQIPTSWRPAFLDFTTLKLYFDLYHSLPNTLSSLALSCLVQLASVRRSLFSNTERAKFLTHLVNGVKHILQNPQGLSHQDNYHEFCRLLARLKSNYQLGELVMVENYPEAIQLIAKFTVQSLQMWQFAPNSVHYLLSLWQRMVASVPYVKATEPHLLETYTPEVSNAYITSRLESVAVVVRDGLEDPLDDLGMVQQQLEQLSVIGRCEYQKTCTLLVQLFDQAARAYQELLAQTANNNPTHQIEITIQEGQLTWLVYIIGSAIGGRVSFNSNEEHDAMDGELVCRVLQLMNLTDSGLSQGGCEKLELAMLSFFEQFRKIYVGDQIQKNSKVYRRLSEVLGLSDEAMVLSVFIRKIITNLKYWGSREQIISRTLQLLTDLSVGYSCVRKLVKLEEVQFMLNNHTSEHFPFLGNNVAVTEMRCRSMFYTSLGRLLMVDLGEDEERFHTFMLPLTAALESLGQLMGAADTPLFAAEEAKKALIGIARDLRGLAYAFNTKTSYMMLFDWIYPNYTPILLHAIELWHHEPQVTTPVLKLFAELVQNRSQRLQFEVSSPNGILLFREASKVICSYGNHILNVEVPKDQMYSLKLKGISICFSMLKAALCGSYVNFGVFRLYGDEALDNALNTFVKLLLSIPQSDLLDYPKLSATYYVLLECLAQDHMAFLSTLEPRVFLYILSSISEGLTALGALKDSYTDTMVCTGCCATLDHIVTYLFKQLSQKAGVYPGKKNAAVTAGGELFLQVLKQHPEILQQILSTVLNVIMFEDCRNQWSMSRPLLGLILLNEEYFGQLRENIIRSQPVDKQAAMAQWFENLMDGIEPNLLTKNRDRFTQNLSMFRRDINDSLKGPNMSANSTNDMMTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H2K5</accession>
    <name>A0A8J2H2K5_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Trypsin-1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HICCMSTLAB_LOCUS1491</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001116">
        <property type="protein sequence ID" value="CAG5075337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H2K5"/>
    <dbReference type="OrthoDB" id="7552490at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050430">
        <property type="entry name" value="Peptidase_S1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24276:SF91">
        <property type="entry name" value="AT26814P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24276">
        <property type="entry name" value="POLYSERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0720">Serine protease</keyword>
    <feature type="domain" description="Peptidase S1" evidence="5">
        <location>
            <begin position="45"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAG5075337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="118" mass="12845" checksum="0638D23D3F05F623" modified="2022-05-25" version="1">MSNQSIVKILKVNKMMTLFALFISSAVVIADPLRSNLDLKNSARIVGGNNADIEDFPYQVNFLLDKLDECGGAIISDKWVLTSASCLVDNGAIIRVGSNLKNKSGSLHTVVQVIRHED</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H368</accession>
    <name>A0A8J2H368_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similar to TPRG1L: Tumor protein p63-regulated gene 1-like protein (Bos taurus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS605</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001114">
        <property type="protein sequence ID" value="CAG5073789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H368"/>
    <dbReference type="OrthoDB" id="10012704at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022158">
        <property type="entry name" value="Inositol_phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040242">
        <property type="entry name" value="TPRG1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31108:SF1">
        <property type="entry name" value="HSAC2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31108">
        <property type="entry name" value="TUMOR PROTEIN P63-REGULATED GENE 1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12456">
        <property type="entry name" value="hSac2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Inositol phosphatase" evidence="1">
        <location>
            <begin position="77"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5073789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="274" mass="31793" checksum="BCE910C8D2693783" modified="2022-05-25" version="1">MLDHNQLDEVSSVNFEAATLRISNKEDSEKTREGSNTEEIKKDSSVLSVPYKNIDVHTFFSDRDEVVERAIKEISLWDTEKERVVLLTKNALYTIKYDFISLKLLEFNRVPMIEVDTITYGELEYPKTSIAPRLNGLAEGVSSVIHCAVRQQWSSLASSSEIKFEPRKRNTFGVKIMWNKGKPLSLDKKWNPFAKRIPWVTYTSHPLYWHKSSTSEEQKRFDVDDFHDALMTHFNMQCEFTKSQIIIENYLGLGAILHNRNSLGFFRVRGKVSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H496</accession>
    <name>A0A8J2H496_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Similar to Venom allergen 5 (Brachyponera chinensis)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HICCMSTLAB_LOCUS2373</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001117">
        <property type="protein sequence ID" value="CAG5077108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H496"/>
    <dbReference type="OrthoDB" id="43654at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd05380">
        <property type="entry name" value="CAP_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.33.10">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018244">
        <property type="entry name" value="Allrgn_V5/Tpx1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014044">
        <property type="entry name" value="CAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035940">
        <property type="entry name" value="CAP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001283">
        <property type="entry name" value="CRISP-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002413">
        <property type="entry name" value="V5_allergen-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10334">
        <property type="entry name" value="CYSTEINE-RICH SECRETORY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00188">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00838">
        <property type="entry name" value="V5ALLERGEN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00837">
        <property type="entry name" value="V5TPXLIKE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00198">
        <property type="entry name" value="SCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55797">
        <property type="entry name" value="PR-1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01009">
        <property type="entry name" value="CRISP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035256366" evidence="4">
        <location>
            <begin position="18"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="domain" description="SCP" evidence="5">
        <location>
            <begin position="55"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAG5077108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="215" mass="24414" checksum="EEB3407F02525CE9" modified="2022-05-25" version="1">MTINVFLIFTVVLSTSAQECYPSGCNGEQNTWCKYSSTDPSPNCGQVESTTLTQEEKDEILKAHNDRRAWVANGQVEGQPAGIIPPLQWDEELAELARRWALQCEIGHDKCRYVDRFSVGQNMMWRADGSGYQNLTDMTDGWFSEHVNFDGSGVGAFVWQDDPQIGHYTQLIWGATTHLGCGVLRYYKDNWYNTYFLCDYAPHGNVIGWPVYETT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H4U8</accession>
    <name>A0A8J2H4U8_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS72</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030000524">
        <property type="protein sequence ID" value="CAG5071582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H4U8"/>
    <dbReference type="OrthoDB" id="7701442at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5071582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="90" mass="10864" checksum="BC278DB50E0290C9" modified="2022-05-25" version="1">MGTGKREIMEKKRRLKGKKIFIENDRTRKERNAQKELHRRAWIAKNKEEVKEVKVGFRKLWLDGVLWRTLHLSLYSLDRSTDGLICEQLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H4X4</accession>
    <name>A0A8J2H4X4_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Similar to CHORD: Cysteine and histidine-rich domain-containing protein (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HICCMSTLAB_LOCUS285</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001114">
        <property type="protein sequence ID" value="CAG5073332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H4X4"/>
    <dbReference type="OrthoDB" id="10261079at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1130.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007051">
        <property type="entry name" value="CHORD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039790">
        <property type="entry name" value="CHRD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46983:SF3">
        <property type="entry name" value="CHPADIPLOID STATE MAINTENANCE PROTEIN CHPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46983">
        <property type="entry name" value="CYSTEINE AND HISTIDINE-RICH DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04968">
        <property type="entry name" value="CHORD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51401">
        <property type="entry name" value="CHORD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CHORD" evidence="5">
        <location>
            <begin position="8"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="domain" description="CHORD" evidence="5">
        <location>
            <begin position="147"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="64"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="239"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="244"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAG5073332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="275" mass="30764" checksum="8F3AEF2DD8DE6CB9" modified="2022-05-25" version="1">MSGKKLLCYHRGCGQDYDPDDNKPDSCVHHPGVPVFHDAYKGWSCCNKKCTDFTEFLNIKGCTKSEHSNEKPPEPEKPAVDKSKAAEVIEYRAPVNTEPTIERPPFDTPQKTMQPVVSQALMDQVKSFITNTESLPESLVVKVGQSCKNRGCSVTFTGTDSDNTKCVHHPGVPVFHEGLKYWSCCPRKKMTDFDQFEKHPGCSEGTHVWIAKVVDVENSSVQMLPTKVEIKLKKEEPNSWSKLDIPKETAPAKEAPKEEDNSISERVDAVDLNDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H5C6</accession>
    <name>A0A8J2H5C6_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS391</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001114">
        <property type="protein sequence ID" value="CAG5073448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H5C6"/>
    <dbReference type="OrthoDB" id="7699963at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035239051" evidence="1">
        <location>
            <begin position="22"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5073448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="450" mass="51778" checksum="C48B0914DF3EF872" modified="2022-05-25" version="1">MSKVLLIQLFFITWRSYYVTLSCIKYCTVMASKSGRKPNVDRNKLIETINKHIDTLITKEKKVIHKGHEIWQQIANELDNKLLPESLYSIVTNNKYNVRKKLPNQSLNSTVSSVESENLSDSIEDANIKTDHNFTFTMSFDEYDSMICTSQRKRRKLNGYYTFPKKVFKPYYWENSITNKIWKATHKKCGYNFIDHYVAESKMSGSFQGKCNCGSKIKSTFQVAGDEVTFTCVATPGSGKCKKTYLRNEHRKKAAEKMKSLTTDQYQSEIAVEKNMLQHDPQPPHLSKASVLRTAKAELIRSEYHHSDPIVSLSIMKEHVWPGTIHDLSFSPFYVHYWTHHQRDVYIKYAAQGNSCIFIDATGGISPKFTKLDKTTTSSLFLYLIAINVSGQQFTIGQMISERQDTNAIINFWNDWLKYGFPQPKEVVMDSNKAQLIATITVFTPYKTIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H5I4</accession>
    <name>A0A8J2H5I4_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Similar to PHF20L1: PHD finger protein 20-like protein 1 (Homo sapiens)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">HICCMSTLAB_LOCUS860</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001114">
        <property type="protein sequence ID" value="CAG5074088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H5I4"/>
    <dbReference type="OrthoDB" id="161570at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044545">
        <property type="term" value="C:NSL complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.890.10">
        <property type="entry name" value="Methyl-cpg-binding Protein 2, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016177">
        <property type="entry name" value="DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001739">
        <property type="entry name" value="Methyl_CpG_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043449">
        <property type="entry name" value="PHF20-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006612">
        <property type="entry name" value="THAP_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15856:SF51">
        <property type="entry name" value="MBD-R2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15856">
        <property type="entry name" value="PHD FINGER PROTEIN 20-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01429">
        <property type="entry name" value="MBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20826">
        <property type="entry name" value="PHD_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05485">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00391">
        <property type="entry name" value="MBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54171">
        <property type="entry name" value="DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50982">
        <property type="entry name" value="MBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50950">
        <property type="entry name" value="ZF_THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="THAP-type" evidence="12">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="domain" description="MBD" evidence="13">
        <location>
            <begin position="440"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="595"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="304"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="520"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="645"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="784"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1043"/>
            <end position="1064"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1108"/>
            <end position="1140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="331"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="358"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="396"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="525"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="819"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="1117"/>
            <end position="1137"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="14">
        <location>
            <position position="1196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CAG5074088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="1196" mass="134945" checksum="52B0008B685A79FB" modified="2022-05-25" version="1" fragment="single">MAMMYMLSDLLLRSKWLANAGFEEYYKPFPGQFVCYRHFLKNDYEINKNMPGHKFLLKKGSVPTVFDNYHNHPDPVVPLTVTKSPVKSNNNLPENLIPTNSEMTQLEPENIPEAQGSNSKPEELKKEVPNKDLLINSSNKFESIKKPAGSDNLGIQIQNVIDTTVEKKEFTEKFTEDPPAEPPPLLDDPVDNVKLNEDSCKSNGDIENNIQEPNVENGKFSKSRNAVVVETDWREREILINFDKRRPTTNEWISMDSPRLRSIRPSEEVWVQPTESSKMHKYDVLFDDGYQKIVRGSKITKIASASSKGMETDAYIGSKQERRDKSRKHTVKDLFSHKKRTKLDGVDQSLTKKDDTSLTDAEQLNNSESMNESTDAAGTELEESILEQVPIETPKPKPRNGAKRKREVVVDYDDDGGPEWVDGEPQGIESFVVDGNEGSRRSILIPDKKLPPGWQKHFIQRKTGNSAGKWDAVFLHEASSKKFRSRSDLRAFFDTQRLSNFDPNKFDFCVHRRKRPAVAKEKLDSSASAGTSSATNEPARKIKTLLPKSKTAATNDLLLTSVTPSYLTPVPATPVEDTGAVFIGGLRVEMEDSAYKCPKEGCSKTFRKENLLQMHIKHYHPEFSKYLGSTPNVADLAYARTIGEPIIDGTPKKSNSNYVDKPTISRSDKRKSHSDKFSTPLAHQSFAASSPLSVASPDMSQIDHPMNGLKDDIKSDLMSPCSNASLDIDDEMAKKSDGSCAMSPGTLFDLKSREEKTQAGIKTLLPLRPANSVDTTRLDRSKSLDDTFNADRGQRKRQLSEYSSDNSTKSKKRHGIQELTDDYGDLDDSAMDIDGPSPLVYRFSRRKSDSKSDDNSQNGECMMMMINGEMVKVEQLKREEIINCTCGVVEEDGLMIQCDLCLCWQHGHCNSIEREKDVPEKYICFICQNSYRQRPSKKYAHDQDWIKEGKLPSLTNRHKNQEKLNKRFAMLKRSNDLVGALLKPTTPDMDITQLDIKPEGTCPMTKNEINGDKSINSDSELMKILEEDNSCVNDDLKVKKEISDSKNIEDSPVVKNETEAPQTDKIEDIKIEDSEENIKDQLNPSSTDSQVQFNASNNNESLLNDCKSEQAKSKPFEPLPEQPPPPQQPFIPEPEAPIDPDECRLRLLNHIEHFQNHMEVHLTSVESQVSFLEAMDPDDDLAADKVDIRCKETIQM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H6N1</accession>
    <name>A0A8J2H6N1_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS2845</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001117">
        <property type="protein sequence ID" value="CAG5078805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H6N1"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23107:SF34">
        <property type="entry name" value="HTH LA-TYPE RNA-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23107">
        <property type="entry name" value="SYNOVIAL SARCOMA ASSOCIATED SS18 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="46"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="185"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="248"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5078805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="337" mass="39324" checksum="0343D2D25FC59E0C" modified="2022-05-25" version="1">MMYALVKVPRDNNKKVIVETRYILNFSEYNVLTKNNVKELSNENVHVRNPKINNSSALDTSTDDDDGDKKSGVTKAKLVRKIKNQNKLKVKKQRTEEIIQAFQKIQKGNSEKITTDTHSGDDSLSEIDEIEQNSSNPENNQENGRVIRKNRITSEIDSKSHMFDDPPEQYIEPIVIINENNFANQEETDEDNSKNPPSISTKKDKNLTRPILASISKVDSNPSVPQLLEDNRMKEEEILLINSTNNSNNNNQQKQKQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQHDRYNSYNYLENDVSCWRRYLYGCVTGLLIKSTHSHQRHQHSVKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H6Z9</accession>
    <name>A0A8J2H6Z9_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Similar to ARSJ: Arylsulfatase J (Homo sapiens)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HICCMSTLAB_LOCUS3175</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sulfatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5081033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H6Z9"/>
    <dbReference type="OrthoDB" id="103349at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008484">
        <property type="term" value="F:sulfuric ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16029">
        <property type="entry name" value="4-S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047115">
        <property type="entry name" value="ARSB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10342">
        <property type="entry name" value="ARYLSULFATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10342:SF273">
        <property type="entry name" value="RE14504P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035191127" evidence="6">
        <location>
            <begin position="16"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="domain" description="Sulfatase N-terminal" evidence="7">
        <location>
            <begin position="39"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG5081033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="457" mass="51599" checksum="1A73F0439B32BB84" modified="2022-05-25" version="1">MRTIGLIFLCGLTCATLEKSPHIVFIIADDLVIMAAEPWGLSLTEKILPEYLKDLGYKNHIVGKWHLGHYMRNYTPTYRGFESHLGYWTGHQDYFDHTAVEWPDWGLDMRRNLEPAWDLHGKYSTDLFTEEAVRIINNHNQSDPLFLYLAHAAVHSANPYNPLPAPDQEVAKFLHIKDYKRRRFAAMLSKLDDSVGAVVSALKKQSMLQDTVIVFTTDNGGPAAGFNDNFASNFPLRGVKNTYWEVSRELMDITDWLPTLLTVAGGNNSILPTAIDGIDMWESLNNKGPSPRRVVVHNIDDIYGAAAITVDDWKLVKGTTYRGTWDDWYGSSSWDILYNTTEVIESSAGSAVTDLGLPLTLNLIINLREESRVQCGKKNTTLAKCRPLVKPCLFNIRSDPCEFNNLAEADNEMLVNLMDVLNKVNKTAVPPRKVDSDPRSKPSLWDHTWTNFGDYTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H775</accession>
    <name>A0A8J2H775_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS3316</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5081550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H775"/>
    <dbReference type="OrthoDB" id="7699527at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="15"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="84"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5081550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="140" mass="15499" checksum="EDB307F7D6601886" modified="2022-05-25" version="1">MSVIANKTKKILVLRPGERDWEYRGRPGTQQYSHTSVSPWYTAPAGSSDETSDPSPSISLPTPPPPPKAVVPPPPPPPPRPTRRSVTFAESPSKSPRSPKSPKSPWVFRRRSTIKSLNVAVPWTPATPSHWDNRKAEYVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H7F0</accession>
    <name>A0A8J2H7F0_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9 11">Ubiquitin carboxyl-terminal hydrolase</fullName>
            <ecNumber evidence="3 11">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HICCMSTLAB_LOCUS3268</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Ubiquitin-protein hydrolase is involved both in the processing of ubiquitin precursors and of ubiquitinated proteins. This enzyme is a thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminal glycine of ubiquitin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 10 11">Belongs to the peptidase C12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="3 11"/>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5081377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H7F0"/>
    <dbReference type="OrthoDB" id="427186at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd09616">
        <property type="entry name" value="Peptidase_C12_UCH_L1_L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.532.10:FF:000006">
        <property type="entry name" value="Ubiquitin carboxyl-terminal hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.532.10">
        <property type="entry name" value="Peptidase C12, ubiquitin carboxyl-terminal hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001578">
        <property type="entry name" value="Peptidase_C12_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036959">
        <property type="entry name" value="Peptidase_C12_UCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10589">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10589:SF17">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01088">
        <property type="entry name" value="Peptidase_C12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00707">
        <property type="entry name" value="UBCTHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52048">
        <property type="entry name" value="UCH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 10 11" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10 11" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="5 10 11" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UCH catalytic" evidence="12">
        <location>
            <begin position="2"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="10">
        <location>
            <position position="88"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="10">
        <location>
            <position position="162"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="10">
        <location>
            <position position="82"/>
        </location>
    </feature>
    <feature type="site" description="Important for enzyme activity" evidence="10">
        <location>
            <position position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00055560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00073226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS52048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAG5081377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="223" mass="24641" checksum="B399C82B43FCB878" modified="2022-05-25" version="1">MTLVPLESNPEFIHKIGVPAKWKLSDVYGLDEPLLAMVPKPVLALILLLPETEKAKAYAAELESKIKAEGKEPPKNIFHMKQCVTNACGTVALIHSILNNLDQIDLNDGALKNFYEEAKDLSFVERGELLMKETNEIIDAHKQLAKEGQTQAPPEDEPVVHHFVAFVEKDGTLYELDGCKSAPINHGPTTKEAVLDNAAKVCKEYMARDPGEVHFTMMALVAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H7P4</accession>
    <name>A0A8J2H7P4_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="22">Sodium/potassium/calcium exchanger 5</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="23">Na(+)/K(+)/Ca(2+)-exchange protein 5</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="24">Solute carrier family 24 member 5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="27" type="ORF">HICCMSTLAB_LOCUS3144</name>
    </gene>
    <organism evidence="27 28">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="27" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="21">Calcium, potassium:sodium antiporter that transports 1 Ca(2+) and 1 K(+) to the melanosome in exchange for 4 cytoplasmic Na(+). Involved in pigmentation, possibly by participating in ion transport in melanosomes. Predominant sodium-calcium exchanger in melanocytes.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>Ca(2+)(out) + K(+)(out) + 4 Na(+)(in) = Ca(2+)(in) + K(+)(in) + 4 Na(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:69967"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
            <location evidence="1">trans-Golgi network membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Melanosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. SLC24A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="27">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5080932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H7P4"/>
    <dbReference type="OrthoDB" id="2127281at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005262">
        <property type="term" value="F:calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008273">
        <property type="term" value="F:calcium, potassium:sodium antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1420.30:FF:000009">
        <property type="entry name" value="sodium/potassium/calcium exchanger 5 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1420.30:FF:000015">
        <property type="entry name" value="sodium/potassium/calcium exchanger 5 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1420.30">
        <property type="entry name" value="NCX, central ion-binding region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004481">
        <property type="entry name" value="K/Na/Ca-exchanger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004837">
        <property type="entry name" value="NaCa_Exmemb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044880">
        <property type="entry name" value="NCX_ion-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00367">
        <property type="entry name" value="calcium/sodium antiporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10846">
        <property type="entry name" value="SODIUM/POTASSIUM/CALCIUM EXCHANGER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10846:SF73">
        <property type="entry name" value="SODIUM_CALCIUM EXCHANGER MEMBRANE REGION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01699">
        <property type="entry name" value="Na_Ca_ex"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0050">Antiport</keyword>
    <keyword evidence="11" id="KW-0106">Calcium</keyword>
    <keyword evidence="7" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="15" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="17" id="KW-0406">Ion transport</keyword>
    <keyword evidence="18 25" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-0630">Potassium</keyword>
    <keyword evidence="6" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="28" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <keyword evidence="16" id="KW-0915">Sodium</keyword>
    <keyword evidence="19" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="12" id="KW-0769">Symport</keyword>
    <keyword evidence="9 25" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14 25" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="9"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="90"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="160"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="195"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="220"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="330"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="365"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="402"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="432"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="26">
        <location>
            <begin position="96"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="26">
        <location>
            <begin position="323"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00033627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00058187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00069887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00081356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00082809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="Pfam" id="PF01699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="EMBL" id="CAG5080932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="465" mass="52068" checksum="B97AAF9855317BE5" modified="2022-05-25" version="1">MTKRHKHLIFYRMLLVIGIPTVYFACISLSGFFKVKSTELDPEIFGKNEIRLRKLMQVEEPEVNRSNQCIAPAIDEFPSDGFTAEQRRSGFIVIHIVLAIYLFLLLAVVCDDFFVPSITKICEKLNVSEDVAGATFMAAASSSPELFINVVGTFVTQGDIGIGTIVGSAVFNILAVPACCGLFASQALELDWWPVSRDSLAYAITVGLLILVFRDGRVEWYEGLILVITYVLYILTMYFNKRISKCMGSMVSKRKEYKNLDNSSLLPKHFENGKVNSFEPIEDEDLEIVNLTNWPNSFWEKLWWMLTWPINFVLLITIPDCDTLEIPDSVMGLTFLAAGMSVPEAVSSVIVTNQGHGTMGISNSIGSNVFDILLCLGLPWFIKAAFVPKNPGLHYVQINSEGLVYSSISLFSTLILLYVAFACNKFRLDRKVGFTCLFMYACFLVIASLTELNVFFQVNLPTCVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H7T6</accession>
    <name>A0A8J2H7T6_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">rRNA-processing protein FCF1 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HICCMSTLAB_LOCUS3513</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the UTP23/FCF1 family. FCF1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5082282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H7T6"/>
    <dbReference type="OrthoDB" id="76105at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09864">
        <property type="entry name" value="PIN_Fcf1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1010:FF:000004">
        <property type="entry name" value="rRNA-processing protein FCF1 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006984">
        <property type="entry name" value="Fcf1/UTP23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037503">
        <property type="entry name" value="Fcf1_PIN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12416">
        <property type="entry name" value="RRNA-PROCESSING PROTEIN UTP23 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04900">
        <property type="entry name" value="Fcf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00670">
        <property type="entry name" value="PINc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="PIN" evidence="7">
        <location>
            <begin position="27"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00024026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00069243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG5082282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="158" mass="18113" checksum="9F104EEF92E6CDB8" modified="2022-05-25" version="1">MTNDSASGPQVSSALFFEYNTQLGPPYRILIDTNFINFSVKNKLDIIENMMGCLYAKCIPYVTDCIVAELEKLGRKYSIALKLIKDPRFERLRCSHKGTYADDCLVQRVTAHKCFIVATNDKDLKQRIRKIPGVPIMYVAQHRYTIERMPDAYGAPRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H7W3</accession>
    <name>A0A8J2H7W3_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS3455</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5082091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H7W3"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5082091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="122" mass="12607" checksum="D303809D8CE4FD68" modified="2022-05-25" version="1">MLSPTPSPTLAVTVGSRQHSGGQSTVPAPLALLASLLGSRSFWLAASASSVSNTASESNVSSFSQVSSRFIIISLNPRTSATLNVFRYPAAAIVIHDSQPHPGAVSGPQAKTTNTVYNIKLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H812</accession>
    <name>A0A8J2H812_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Similar to LBR: Delta(14)-sterol reductase LBR (Gallus gallus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HICCMSTLAB_LOCUS3860</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ERG4/ERG24 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5083511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H812"/>
    <dbReference type="OrthoDB" id="5326588at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005637">
        <property type="term" value="C:nuclear inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050613">
        <property type="term" value="F:Delta14-sterol reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006695">
        <property type="term" value="P:cholesterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04508">
        <property type="entry name" value="Tudor_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001171">
        <property type="entry name" value="ERG24_DHCR-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21257">
        <property type="entry name" value="DELTA(14)-STEROL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21257:SF55">
        <property type="entry name" value="DELTA(14)-STEROL REDUCTASE LBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01222">
        <property type="entry name" value="ERG4_ERG24"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="248"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="291"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="336"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="367"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="425"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="465"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="500"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="49"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="49"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="62"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAG5083511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="603" mass="68306" checksum="776A47A1667D2F2C" modified="2022-05-25" version="1">MKFMAGEQVLAKPPNIDEFQKGKILMARGDKYVIQFEGGKEHTVLENNIQPERASRSTARTIKGKLYKSPLRKSPGRKSPSRRSPSRRSPGRRSPGRSPGRPKRLIKITSKQSDDEKSFKTDSQSTMSESDDVAELIPLQSRLKDQSAPTATRRSVRILNNMLKDSSVSLRGIDRAVSLPVERKTIMYDYLSDAKERGFSVQREPDIQKLYYEEEVLPDSSTTEKTKKKEKEQEKSLKIELVSKPQEWLGWIGATCLTILLPCAIILPQISCQNNKCQLPDLKFSTKLQSYFNLSSALAYISFLLVVALTSLLPLGRVVDGMQMRSGKLQYRLNGAYTLLLVLVSYKTAEIFGIDVTNFIIDNLLRFSVLSWITGTILSIALFIKGGRIPVSTANIYGSTNNFIYDFWQGREINPRVLKLDIKMILSRVSIIGTLVIIIAVMMKSSEDVDFGGLSNFTDLAALKAFLDLNPTIMTVGLMQVFYCLDYFYFEDATLTSFRVLYEGTGYMTCVAGLMYPFLITLGPRYLLAQEVHPNYLGDILMNWAMVLVTLNNDLVLYWSALCCTLVLAHRALRDNSRCHKRYGAAWENYCLRVRSLIFKRIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H8G8</accession>
    <name>A0A8J2H8G8_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Myb/SANT-like DNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS4131</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5084537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H8G8"/>
    <dbReference type="OrthoDB" id="7701172at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044822">
        <property type="entry name" value="Myb_DNA-bind_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47595">
        <property type="entry name" value="HEAT SHOCK 70 KDA PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47595:SF1">
        <property type="entry name" value="MYB_SANT-LIKE DNA-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13837">
        <property type="entry name" value="Myb_DNA-bind_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myb/SANT-like DNA-binding" evidence="1">
        <location>
            <begin position="103"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5084537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="359" mass="42364" checksum="E6806F80868D4DB2" modified="2022-05-25" version="1">MDEEIYFCKHCDGLIESFNEAGNHQCFRGKEHIYQDEEDNTILFVHNYENDNKENREEQVFNNEKSEVHNHLLSDYTAFIESDEDLSQSVDFQTESNPKKNAVWTKQATMALLSLYEANLQMLTDIGKKSRVWKKISEGLKELRIQVTADQVKWKFNRLYNKYKECIDNNNKSGRAHMTFEYYEQFEEIFHKEKKVSTSSTLSSSILTTDEKKRKHDIIGSKNISKSKKLKIDAISSEKNLPPVDKSPKLKTTPIADVKQTARNQQRIQSMEILENIKENQKARDEKMTKYLKMKEKEMDLKKKAIDVRETEMQVKRDVATEKLKFNEKKHKDWLNIEKLKCELLKKLLKNRTDSEESD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H8H6</accession>
    <name>A0A8J2H8H6_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">DNA 3'-5' helicase</fullName>
            <ecNumber evidence="11">5.6.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">HICCMSTLAB_LOCUS3098</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>Couples ATP hydrolysis with the unwinding of duplex DNA by translocating in the 3'-5' direction.</text>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the helicase family. RecQ subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.4" evidence="11"/>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5080766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="18781at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009378">
        <property type="term" value="F:four-way junction helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18018">
        <property type="entry name" value="DEXHc_RecQ4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22289">
        <property type="entry name" value="RecQL4_SLD2_NTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000772">
        <property type="entry name" value="ATP-dependent DNA helicase Q4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004589">
        <property type="entry name" value="DNA_helicase_ATP-dep_RecQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021110">
        <property type="entry name" value="DNA_rep_checkpnt_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00614">
        <property type="entry name" value="recQ_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710:SF108">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE Q4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710">
        <property type="entry name" value="DNA HELICASE RECQ FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11719">
        <property type="entry name" value="Drc1-Sld2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 18" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0862">Zinc</keyword>
    <keyword evidence="13" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="15">
        <location>
            <begin position="595"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="16">
        <location>
            <begin position="750"/>
            <end position="927"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="17">
        <location>
            <begin position="949"/>
            <end position="1118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="173"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="269"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="411"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="173"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="269"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="411"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="424"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="442"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00034617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00034808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="CAG5080766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="1433" mass="160257" checksum="AA5E6A2783A590F2" modified="2022-05-25" version="1">MNSLDDPAVNNKYLKCKIRVKKWESDFMEKYGRKPTKNDIKSADKTIRDSYKNYWKLKTKVLEETLLDITFSDEIESNVSLNTSSLDFLSQDIKAPEKSVLDKSTGSQSVVNTENIAPDVPKAEPSVPVDTLNVDGAWGDHLNKDYEAPKKKKILIGKSSSFQLSQKKFTSSSFLKRNPRKSLSMNKSKSKFNLNKSASEADNSNNTSLTAATIEDSSDLLLADPIKIVTQKIKVTNQPINIIQQVLSGKSVTVDRKLDSGWLARCSKDDNEAVEEPKSESKRLSGISDSGIESLDNNYQETQDTCLKESPSQVAEVSDDDFVCVSDSEEESRNKRIRNWRRTASDLSNVCKRPRTDFSYRTFSFASPLNKQSFVSPAIEKEIKRLEAEKVVTEKHVPLVKENFLVEKEEKGVEQTINSEEKGKKKRGRKPAVKKKSSETKKPRRTTRRKVKYSEDSSEETFEDKELSNEKETPEIFIYGVEALDVVPRFAVPQDTNGDLVTEFCESIEAEKTAVTKAKPKAAMSAKEKLEAKIASGNVNDNFVRINLKKKIFVRGKKSFNFSRYKKNQWKHKKKELASGEGSLDLADLAEKNTCFKCRGSNHVSRNCPAMKSDELIPLGDTDVSEFPTLEEAKHMASQEAVKAHAHRMHHLPKTLSMSTEEKQPEEELENCPYDFDDDFEEEIPEDQPFVGHKIPQELIDKLLPPENGVIDPVFPTSSDGLVIPTPAEVLQTLNKFGHKSFRPGQEKAVMRILSGQSTLVTLSTGSGKSLCYQLPAYLYAKRSHCITLVISPLVSLMDDQVTGVPGFISAAALHTGQTPKTREKVIEAVKEGRLDILLVSPEAIVAGEKSTGFGSLLRQLPPIAFACIDEAHCISQWSHNFRPSYLMVCRVLMEKMGVRTILGLTATATRATAESIVNHLKIHDGMAGVISDVPLPNNLTLTVSKDDQRDRALVDLLRSPRFKDCNSIIVYCIKREECTRIAGLLRVSLQDLETGKPKPKAKVSTIAEAYHAGLAASRRKVIQKHFMSGDTRIVVATVAFGMGINKLDIRSVIHYNMPQSFEGYVQEVGRAGRDNLPAHCHLFINPQENSDKWELRRHIYANGVDRHTIRKLLQKIFVPCSCATSGKRCPGHEVAIPIDETVRSLDVTEEMISTLLCYLELHPKKFVTVLSSVYVNAKVTSYNGAPALKAAAQSSPPLAMAIALDRKKGVTHDNDTIIEFPVVDVAAAIGWDSGVVKSHLKNLEWTTVNGKSKRSSISVRYDTLGLRVRAPGDLTDAELDEALDALASRTQNQETSSLEQLEIIHTVMNKYSCQRVKDCEELNDENIYKSDQLKNVIRQYFQSPSPLSIVEIGAKKNNSANEAQLVNDIRSLIASYRDNNFTGRAVARIFHGIQSPNYSALTWCRCRYWRAYLAVDFNYIAQIATREILAMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H8K4</accession>
    <name>A0A8J2H8K4_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Gustatory receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HICCMSTLAB_LOCUS3128</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Cell membrane</location>
            <topology evidence="1 8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the insect chemoreceptor superfamily. Gustatory receptor (GR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5080884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H8K4"/>
    <dbReference type="OrthoDB" id="6366728at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030425">
        <property type="term" value="C:dendrite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043025">
        <property type="term" value="C:neuronal cell body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007635">
        <property type="term" value="P:chemosensory behavior"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008049">
        <property type="term" value="P:male courtship behavior"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050909">
        <property type="term" value="P:sensory perception of taste"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013604">
        <property type="entry name" value="7TM_chemorcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21143:SF133">
        <property type="entry name" value="GUSTATORY AND PHEROMONE RECEPTOR 32A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21143">
        <property type="entry name" value="INVERTEBRATE GUSTATORY RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08395">
        <property type="entry name" value="7tm_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 8 9" id="KW-0675">Receptor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="17"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="79"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="108"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="190"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="302"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAG5080884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="333" mass="38659" checksum="349BD73C8C444A29" modified="2022-05-25" version="1">MTTYFVVLYLSPSWEKIYIHSCTLGTIGKGLIILGAITSVIIWFIYILKQSVLVSIANEIYRVNNDLKRCKHYKLKTNYFPYFIFIGNFILCFFIMLVGIVTHQYVSVPFWSTPCILISWVIIQYTITLIVINQNIACLNEMLLKLGNVDTKIKFQKLFVTKFPLREAIILDIMNINHANKKLCKICNDVANFFTIPILSAIIYFAMTTIYELRYLFLSITNKSYGTIPPFLIHLDSVSWFMIVLFDLTAFTSSVTSTSREFKKTALYIHLLLDRCTMDLITEKTLIEFSRDLLHRNVEFTAFHITVLDGSLLHSFFGTIVTYLIILTQFRVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H9A7</accession>
    <name>A0A8J2H9A7_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS3465</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5082132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H9A7"/>
    <dbReference type="OrthoDB" id="8117927at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5082132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="179" mass="19817" checksum="E1EC4CEFBC78833D" modified="2022-05-25" version="1">MLITGSSAAPLASVHVKFISPPHIYEHQLTTDGHNTIAQKSFLSIGRRSADFANKLSSGFFKSPVSSFARRNPEALWPDGVFIKPVDVNDLGISSQDSSQFHSTPDFSNGLAYPDPLLLTDESATSAIRHLYGRTGLFFHEIPHLRSLLRLQHERRSNGLQDNVLSSIRPQSPFYNSSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HA16</accession>
    <name>A0A8J2HA16_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">MYND-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HICCMSTLAB_LOCUS5375</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5089785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HA16"/>
    <dbReference type="OrthoDB" id="7632287at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19757">
        <property type="entry name" value="Bbox1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01753">
        <property type="entry name" value="zf-MYND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01360">
        <property type="entry name" value="ZF_MYND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50865">
        <property type="entry name" value="ZF_MYND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="71"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="MYND-type" evidence="7">
        <location>
            <begin position="1179"/>
            <end position="1216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="167"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="250"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="330"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="532"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="169"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="532"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG5089785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="1228" mass="136756" checksum="28E9C52C7572CED5" modified="2022-05-25" version="1" fragment="single">AAAALSPSYSPESSSSSSVKHRSYFPLTSIRNCCTGCCWLFGLQPVPVPVGVYHSTDTFVANVVICFKINFYYYFLSYWLAGYALLICYVYGTMIDSSHAQGSSGLATALKDRPACVMPVQPNRSLPVLPAPHSPYRAIVSRRTSSVSDSGTSQQMLQNVQGTFTNANSTGSLSSSSSSSASTTSSSSPSSSPSPSPLLSSSFTSSSSATIYGTPQKVRCTLDLDKIGMPNLMKNNELSRKPVINIIQESRSHEKSNQNISRRLGNKRKSDDGIENINTNTGYASSRICAKDTINNYNFIDISKSPERYDTIVADSSGNVDPLSTQIYYTDSNAQKRESGPFKKRRKRKEKKLEEEETKITGQKVVPPLRLKKIQSLQANVSEYQPNNDEERVNQIIERERQECMPKFRYYQPKPPEVPIVPDTRPTSKEHATNYRIVTGQTPPYDERIDSSTMPSKDLQGLLFRKNNHNFKTDKLKQVNSPSKFDKAAFDSCVKQIKKLTNLLEMLPEVSPEAAKDNVENTVQIMNSVKTNDLPNLNASPPSSTTFTDLLPSLNNSPSPEPPKLSPKTSVDFEATEERNSPPLLPRATSSNGENYDDWEGSGYHKQINSNYNDNESEFNSSVNSSIITTTTGSIVTEQIDIDDKPEYLDLSTNLTKSETFVDAVSNKITKELSRIEVDCDTEQVLKIDLRNSLRPENMVIDTTSLSKYEKESDAEYSPENRLRIDESEELQEVQHKEPVGGATIKVVDNLTSAAAAARTAVATAAITSSCDIFNNQPSKGKSKLKDRRVAESPKSNIIINEQQFPSFGNWVAKISTKLPNHQLSRLITDKNTRPNSAISVTNEVPSFSHYYHYYPQLQQHQEAAKIPASPGLKHKNGLEASSKTLTAEPQLKNQTWEPAEQPSQSQLLQSNSTSNISTSLLETQLQQKPQQIDPQLYPSAQMNKLLARNYSVDPYRVPLLRPTSQLPDPLSTNSIPYHSSASPLLNSLSMSPSSPLSYWHQTIGKTHPESKRGFTDIPLNYDPISLAKRSAYSQYHSLLPTVPINLMNPSYQIPQQRQQQPQQHPSPYDRLWDKSGHCLRPPDSPIPALNYSPWQSALFPPESLLPGRSYLNSNWTADPRNLLSTITPAMQNFASPYQSISVPRVRNIKDRPEQVRNCETPHLGKVDYSPNTARTFQCSNCGSRGPVYKCLGCEAAYYCNETCQARHWNCHVATCPKKMPKLKKVVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HBG3</accession>
    <name>A0A8J2HBG3_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Chitinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HICCMSTLAB_LOCUS5936</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the glycosyl hydrolase 18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5092132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HBG3"/>
    <dbReference type="OrthoDB" id="76388at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004568">
        <property type="term" value="F:chitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.50.10:FF:000003">
        <property type="entry name" value="Class V chitinase CHIT5b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011583">
        <property type="entry name" value="Chitinase_II/V-like_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029070">
        <property type="entry name" value="Chitinase_insertion_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001579">
        <property type="entry name" value="Glyco_hydro_18_chit_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050314">
        <property type="entry name" value="Glycosyl_Hydrlase_18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177">
        <property type="entry name" value="CHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177:SF390">
        <property type="entry name" value="CHITINASE 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00636">
        <property type="entry name" value="Glyco_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54556">
        <property type="entry name" value="Chitinase insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01095">
        <property type="entry name" value="GH18_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="23"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="domain" description="GH18" evidence="9">
        <location>
            <begin position="111"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="84"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="92"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAG5092132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="479" mass="53807" checksum="BC58116F2D0D1E36" modified="2022-05-25" version="1">MVNRIPVPQAKYELLTSVRQTNWKSPVVCLTFVFIVVGSLFALRVCSDLLPSRNLESGPLREVIITTEDATIASWTRRARMYAESSKENQNADRNTTLVTAPSSRSPSSGKILVCYYTLPRTMNTTEELSPAHIDPNICSHIIVGFASVVNSTLSLGSNTQIYNEISSLKKLQPKLKVMISAGGINEQTLGFPEMVKTHANRKKFIRSVLNITRAFDLDGLDVDWEFPAWLGNNERQKIWFVQLLQELRKEFDRSARTLILSAAVAAPPAIIDDSYFVPNIAEYVDFINLMAYDLHYYVWYLPVTGLNAPLYPRASEIGYIATLNVNYSANYWVSKGMPREKIVVGVPTYGHSYQLDNVDNHGIMAPAKGFGRLGVDGFVFYSMVCWLLSVGGQRVFDQESRAPYVYKYDEWISYEDADSVTAKAEWIKANDFKGAMIFSLNTDDWSGSCSSKDGNETFPLTRILSKTLLREKLTPPGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HBP4</accession>
    <name>A0A8J2HBP4_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">XK-related protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HICCMSTLAB_LOCUS4318</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the XK family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5085245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HBP4"/>
    <dbReference type="OrthoDB" id="6356248at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018629">
        <property type="entry name" value="XK-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050895">
        <property type="entry name" value="XK-related_scramblase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16024">
        <property type="entry name" value="XK-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16024:SF4">
        <property type="entry name" value="XK-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09815">
        <property type="entry name" value="XK-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="62"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="99"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="182"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="222"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="251"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="279"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="322"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="353"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="396"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="511"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="542"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="636"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="461"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="636"/>
            <end position="653"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU910716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAG5085245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="736" mass="82935" checksum="F090D61C2E85DE52" modified="2022-05-25" version="1">MAHQHVQLNNNNNVNGNVNNNNNNNNNINNVNVNGNVNDVNVNVNSNINNINQHEFLPLCDVLFNIISLASYFCDVVFDLAMGYALANHPTAPAVLFPISIVLVVTSLIISQVVSIRWYLWGARGKLNPTESLPEKNRVRNWILWCVVFLHTSQIGVLWRYFKLFIPVDLTYVKHEVRELCVLRLIHAFCEAAPMLLLQLYLLSTSLTSKDRDREDTKLSELTAVSAGLSLWSVCWAVASFSKGAARLRNLERLVLTWLGVLAQLAWRLGTVSARVGALVAYASLYGGSWLLVVLGLHWLSMLTWLLLTPDGLFHGGERLTLARKTFLACLLAFVYVFAYVNLHETNHRQKMIIFYTVMFLENCLLISVWAVGASAEIGRQVQIGAANPDQVQIRPVTLVLVLMALFFGGLFFMGLYYRFFHVRRLGYEAGGRMNANGMPQDVDKHLQYNNYVNEVQVRPLHEEEEEKEQAKIQIGTLNVHLIREKLREKKQQQLRELRAIQEEIKEGKLVPPGETSETAITGNPPPQKKLQPTANTLQFAGLGSGALSPTGSGSNVPGLENVPSQWPPIKMHCLVPPAPPNYHVIGNDWKRERPETPEILLAPRCLPHHYPYWTSNHSDLEGSQVSLPRSYTLPREFKYHSGNPSRERRDVDSADNEDETDTELRDGIEGGKQYIFPDRQMSQSQIEDCLPSEGLNSPSGVISSIDDNFDCYLNNSYGSRVNQLLKAKVKHETKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HC04</accession>
    <name>A0A8J2HC04_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS6688</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5093247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HC04"/>
    <dbReference type="OrthoDB" id="6777617at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035240267" evidence="1">
        <location>
            <begin position="19"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5093247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="83" mass="9364" checksum="5E2F1D425DD8C8BA" modified="2022-05-25" version="1">MCFRLLPRSLQILTILLTDWSIQKICDTMGAKKHMAVMSKSLKENKGVLAAPDQKKGRPLSDNIKSKVIEFYKNDDVSLNVTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HC62</accession>
    <name>A0A8J2HC62_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS6571</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5093076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HC62"/>
    <dbReference type="OrthoDB" id="7697131at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5093076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="137" mass="15965" checksum="5BDA4CDE066DE46B" modified="2022-05-25" version="1">MEDNNTPVLVKNGVEAFTDYDKANMLADQFEQVHNIDLVNNTCEQENIIKQVKKYLEETDNDNENWDKFITSPLITFAKKSNNKKIFQPIKVYNHSIEPANTVKYLGVHLDSRLTYHTHIKQAIRKAFIVQKKKCIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HCD9</accession>
    <name>A0A8J2HCD9_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS4758</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5088202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HCD9"/>
    <dbReference type="OrthoDB" id="10031169at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1730">
        <property type="entry name" value="tricorn interacting facor f3 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042097">
        <property type="entry name" value="Aminopeptidase_N-like_N_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5088202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="221" mass="25290" checksum="67B5CA5902ADD8E3" modified="2022-05-25" version="1">MRRGSVNTWESFGRRNSENMAQFSSNRHEFMTSEPGMSGIEYQREGGFFLSHRKLAIVITAIFLLLVAVGFIGAYAGAFPRKKIEFDTTALIAEDEGSEPADAEKYSLSKWVFPSRYLIKLTPIVEDNKVSRVQGRVIIEFIYNGTKELNNIVLNAKHINISQIRMWPLDNKFNDDNVNNNSNTTTDLPINTNDTTSQPADFPKSIFKLFYLYNYCLILFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HCF5</accession>
    <name>A0A8J2HCF5_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Acyl-coenzyme A oxidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">HICCMSTLAB_LOCUS5418</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the acyl-CoA oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5089890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HCF5"/>
    <dbReference type="OrthoDB" id="538336at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005504">
        <property type="term" value="F:fatty acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016402">
        <property type="term" value="F:pristanoyl-CoA oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033540">
        <property type="term" value="P:fatty acid beta-oxidation using acyl-CoA oxidase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055088">
        <property type="term" value="P:lipid homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.10:FF:000007">
        <property type="entry name" value="Acyl-coenzyme A oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.10:FF:000010">
        <property type="entry name" value="Acyl-coenzyme A oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.110.10:FF:000005">
        <property type="entry name" value="Acyl-coenzyme A oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055060">
        <property type="entry name" value="ACOX_C_alpha1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012258">
        <property type="entry name" value="Acyl-CoA_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002655">
        <property type="entry name" value="Acyl-CoA_oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10909:SF223">
        <property type="entry name" value="ACYL-COENZYME A OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10909">
        <property type="entry name" value="ELECTRON TRANSPORT OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01756">
        <property type="entry name" value="ACOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22924">
        <property type="entry name" value="ACOX_C_alpha1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000168">
        <property type="entry name" value="Acyl-CoA_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10 12" id="KW-0274">FAD</keyword>
    <keyword evidence="6" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="4 10" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA oxidase/dehydrogenase middle" evidence="14">
        <location>
            <begin position="152"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA oxidase C-alpha1" evidence="15">
        <location>
            <begin position="300"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA oxidase C-terminal" evidence="13">
        <location>
            <begin position="489"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="11">
        <location>
            <position position="435"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="156"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="195"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR000168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000168-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000168-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF22924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CAG5089890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="681" mass="76384" checksum="2A5CF41565119AF8" modified="2022-05-25" version="1">MNVDWIEDMPSGGGLDDYRKLASFSWKYLRVIHEDPKNLQFKIRVWKAMEADHEFHMPHYSISCDEQKRRAAIQLARLNHLKFLPSNINNVGYRLKTEALMTINEATNLVSPSLSVKIALGVYLFGNTILSLGTDRHIPVFQDVWNKKLLGCFALTEVGHGSNTKMMRTTATYDPATKEFILHTPDFQAAKCWVGNLGKTCTVAIVFAQLITEGHCHGLNAFIVPVRDSNTYLPYPGIIIGDMGEKMGLNGVDNGFIMFDHYRISKDNLLNRTGDINEDGEYESSFSDPQRILGAVLENLSAGRMGISQEATNRLGAAIVIAVRYAAVRKQFASCLSADKEIETPIIEYELHQWRLFPYLAAASIFRIFMTEFTEVYSQIVGEIHSIVSAIKPLITWTCKAALSESREACGGHGYHKAANLGDMTVNHEPCVTYEGDNNVLMQQTSNWIFRQWLEVQTGSTIGSPLSSVTFLLHGASIINKKFTPNSIADVKDTYEWLITYLVMEMQRKFEEGKSKGLDSFAARSKAQVYCAGTLSRAFGEMIILKYCTTRIDKVINSIPSNESLKVVLEKMMLLYSLSCLEKHLATFYRGGYCAGPQMTDLIRESILNLCSELKPEAVAIADALAPPDFVLNSILGMSDGRVYERLEEVFKFNTGGMERADWWYELKTAGEKPLGLRSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HCK2</accession>
    <name>A0A8J2HCK2_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similar to olpB: Cell surface glycoprotein 1 (Hungateiclostridium thermocellum (Strain ATCC 27405 / DSM 1237 / JCM 9322 / NBRC 103400 / NCIMB 10682 / NRRL B-4536 / VPI 7372))</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS4894</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5088561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HCK2"/>
    <dbReference type="OrthoDB" id="6630782at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47771">
        <property type="entry name" value="LD27203P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47771:SF14">
        <property type="entry name" value="RH73259P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035191132" evidence="1">
        <location>
            <begin position="17"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5088561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="390" mass="44660" checksum="506E2F8DEC3736BC" modified="2022-05-25" version="1">MKYLLVLGLLASAAFAEEKKVEEKTSAAEEPSSKKNEKRGILGLGYGYGYDVGGYEIGAGHGHDHGHGHGHEGFHHLNHFDFDHFDGYGGGYHGEHHVKHVTVVKNVPVPYPVEKHIPYPVEKHVPYPVKVPVPQPYPVEKHVPYPVKVYVKVPVHVPQPYPVEKKIHVPVHVPVDRPYPVKVLVPQPYPVEKHIPYPVKVPVPQPYPVEKKIHVPVHVPVHVPQPYPVEKIVHVPYKVHVDRPYPVPVPKPYPVHVEKKVPYPVDRPVPYPVKVPVDRPVPYPVEKHVPYPVKVHVPAPYPVEKHIPYPVEKPVPYAVKVPVDRPYPVHIEKHVPVPVEKPVPYPVKVPYPVPVHHHEHHDHHEHHQFPEHHGYEHYEHHGGFEHDYHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HDV5</accession>
    <name>A0A8J2HDV5_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS8113</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5096245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HDV5"/>
    <dbReference type="OrthoDB" id="6119141at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="106"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5096245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="178" mass="20068" checksum="CE474406CD1C405B" modified="2022-05-25" version="1">MEDSGIDSDPKPMNHVEDDRLFLTSDSSCSSNQAQPPQRSTTKQLQKKLEARIEQAKRIQRGSDYIKLSNTDKTTLSSNSSGLIPIQRLPIPHKSNEHHPLVEYWQSDSESEDETTLFPISRGKDTSKHKQDLTDTFSIEELSEGSEDSLNLGPTKLPHPHTRTYSPTGCFNCQCRII</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HE42</accession>
    <name>A0A8J2HE42_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Similar to RECK: Reversion-inducing cysteine-rich protein with Kazal motifs (Homo sapiens)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HICCMSTLAB_LOCUS6278</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5092646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HE42"/>
    <dbReference type="OrthoDB" id="5956770at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008191">
        <property type="term" value="F:metalloendopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030198">
        <property type="term" value="P:extracellular matrix organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056978">
        <property type="entry name" value="CC4_RECK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056976">
        <property type="entry name" value="EGF1_RECK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056977">
        <property type="entry name" value="FnI_RECK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056979">
        <property type="entry name" value="FZ_RECK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002350">
        <property type="entry name" value="Kazal_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036058">
        <property type="entry name" value="Kazal_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039016">
        <property type="entry name" value="RECK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055110">
        <property type="entry name" value="RECK-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13487:SF3">
        <property type="entry name" value="REVERSION-INDUCING CYSTEINE-RICH PROTEIN WITH KAZAL MOTIFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13487">
        <property type="entry name" value="SERINE PROTEASE INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23332">
        <property type="entry name" value="CC4_RECK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25027">
        <property type="entry name" value="EGF1_RECK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25028">
        <property type="entry name" value="FnI_RECK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23298">
        <property type="entry name" value="FZ_RECK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07648">
        <property type="entry name" value="Kazal_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22961">
        <property type="entry name" value="RECK-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00280">
        <property type="entry name" value="KAZAL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100895">
        <property type="entry name" value="Kazal-type serine protease inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00282">
        <property type="entry name" value="KAZAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51465">
        <property type="entry name" value="KAZAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035272207" evidence="2">
        <location>
            <begin position="24"/>
            <end position="930"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="908"/>
            <end position="929"/>
        </location>
    </feature>
    <feature type="domain" description="Kazal-like" evidence="3">
        <location>
            <begin position="575"/>
            <end position="636"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG5092646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="930" mass="102459" checksum="8926C5D87294AD91" modified="2022-05-25" version="1">MWVYKFIYLCLWILIEIFCFTDGLQEMSCCSVADGECRTACSEISLVAVGADSEVRESVRTRLTDFCSHDMSEFWACVNSTLSEAENNENWVGRGCCHLAQYPLCQSSCALAGSRMHLENSCRPSDELEFYSCLERREEGESCCSDVSNTTCRSVCRDLFHKPGKQFSLKLYSSKGCFTQVPKCLKTVAESANPENPKQYLNCCKEATTPDCLDACRKVLFKSSSIREILDTLEEKCHPVIPHSPLWSCILQTAPIKPSRVPLDIGKLTCCSRAASTNCQNLCWKAFQADWEVSWSQMETECLSSPNEADLRRCIEDSDEPCEIGCTGLSYCTKFNNRPVNLFRSCSKSADDAARWEADHWARGGVIRGLGVPVRADPSCPLESLRAAACVLQLRPCENRIHETQLCREDCLELMANCVDWTVIGRTHTAASLCAKLSPSRPGTPCVSLRPFMEEAQDEVVAGVLPSADVSTPCKRNPCPDDQVCVLTPNDSTLYKCLPSCTLGEMSRLLVPLNTWVQIPRTDQQGCHHVCQCTANGLEKCKTLNCYNPNSCWVQDRFVAHRTNFYLDCNPCHCFEGEVTCSRKTCSEVRVPSLPCDCPAHYVPVCSRFGVTYASACLAKCTGLSATEIQFGSCSSVDPCQPNPCNPNERCLRKPRVCLSPIHKPCRQYECVPLDCDLRNAQYGPVCDRDNRQHNTSCALIKAKAALAYHGPCLRGCSLRGPICAVNGEVYASECAAWADRTIVDYVGACVAVGVVGDRNIPRCGDAVKCPRLNPSNCIGVTPPGSCCPVCGGAARIFYSKKQLDRIYYMMDEEADKDAVTLEKLLLALGRQIQVAQCTLRGHVTPENDIFIIVQSTAKEPSSLQLRACIAETEKLVVRITERSSKVVAEVPLGSLTRAEVAHGHVSMATGAISSLYVTIVLFAIIKLIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HE67</accession>
    <name>A0A8J2HE67_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similar to Rbp6: RNA-binding protein Musashi homolog Rbp6 (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS5787</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5090897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HE67"/>
    <dbReference type="OrthoDB" id="1875751at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5090897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="137" mass="13916" checksum="325AB2A6B0C12111" modified="2022-05-25" version="1">MKSRRWRQLAAMDLTNGQLTPNNNTPLLTQALSVMNNYQAAQAGFQPASPHGAGGHGGPQGRSFPAANSPGPIDMYSSSAAAAVAAAAADSAVASYVQAANSPQPPTTAFPAIAVSRAPLNYSPGPLIPAAFTNGYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HE69</accession>
    <name>A0A8J2HE69_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Similar to SENP8: Sentrin-specific protease 8 (Homo sapiens)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HICCMSTLAB_LOCUS7694</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C48 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5095408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HE69"/>
    <dbReference type="OrthoDB" id="5065855at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008234">
        <property type="term" value="F:cysteine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019784">
        <property type="term" value="F:deNEDDylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000338">
        <property type="term" value="P:protein deneddylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.395.10">
        <property type="entry name" value="Adenoviral Proteinase, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044613">
        <property type="entry name" value="Nep1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003653">
        <property type="entry name" value="Peptidase_C48_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46468">
        <property type="entry name" value="SENTRIN-SPECIFIC PROTEASE 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46468:SF1">
        <property type="entry name" value="SENTRIN-SPECIFIC PROTEASE 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02902">
        <property type="entry name" value="Peptidase_C48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50600">
        <property type="entry name" value="ULP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 7" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0788">Thiol protease</keyword>
    <feature type="domain" description="Ubiquitin-like protease family profile" evidence="6">
        <location>
            <begin position="14"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="243"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="276"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="246"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAG5095408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="299" mass="34115" checksum="1BD6AFDC7908AD93" modified="2022-05-25" version="1">MSKQDKIVLSYHDSLLRNSDVFLLKNSHWLNDAIIGFYFEYLEQTLESNDNSKNIKLFSPEVTQLLKMTDQEFPFISTDMDYIFFPLNNCKNSDAAGGSHWSLLVYSKAEKTCFHFDSAHGNNNSEARSFGLKISKQLHGDEAARFKNVQCPQQDNGYDCGIFVLCFTDAILEHLKSSPSVETCNFSKVKSLGIDKRRKLLDLIKILSQENIFRSMFPGVTIKNYADAMSAALKAAVSRVSARQKSLKDRSKETPHQTPRKKKIAADFYEGIYKRHPENINPSQGYENTPPERQVMRDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HEA4</accession>
    <name>A0A8J2HEA4_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Large ribosomal subunit protein uL14m</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">39S ribosomal protein L14, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HICCMSTLAB_LOCUS8078</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the universal ribosomal protein uL14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5096175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HEA4"/>
    <dbReference type="OrthoDB" id="274765at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00337">
        <property type="entry name" value="Ribosomal_uL14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.150.20:FF:000004">
        <property type="entry name" value="39S ribosomal protein L14, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.150.20">
        <property type="entry name" value="Ribosomal protein L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01367">
        <property type="entry name" value="Ribosomal_uL14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000218">
        <property type="entry name" value="Ribosomal_uL14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036853">
        <property type="entry name" value="Ribosomal_uL14_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21037">
        <property type="entry name" value="39S RIBOSOMAL PROTEIN L14, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21037:SF3">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL14M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00238">
        <property type="entry name" value="Ribosomal_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01374">
        <property type="entry name" value="Ribosomal_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50193">
        <property type="entry name" value="Ribosomal protein L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00040118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00042938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAG5096175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="144" mass="16051" checksum="448EE5B418610B29" modified="2022-05-25" version="1">MALRGLVIARNIHTTNINNEIRKMARLRVVDNSDIGKRAMLEGKPPKCIHVYNKSLVGYIGDRVLVAIRGEMKKGILVGLRQTQNPKVPRFDSNNVVLIDDNGTPLGTRIHVPIPLILRTILKQKTHSKGADYTKLLAIAPKFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HF65</accession>
    <name>A0A8J2HF65_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ubiquitin fusion degradation protein 1 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HICCMSTLAB_LOCUS8600</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UFD1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5097223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HF65"/>
    <dbReference type="OrthoDB" id="422728at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034098">
        <property type="term" value="C:VCP-NPL4-UFD1 AAA ATPase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031593">
        <property type="term" value="F:polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.40.50:FF:000001">
        <property type="entry name" value="Ubiquitin fusion degradation protein 1 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.330.10:FF:000002">
        <property type="entry name" value="ubiquitin fusion degradation protein 1 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.50">
        <property type="entry name" value="Ubiquitin fusion degradation protein UFD1, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004854">
        <property type="entry name" value="Ufd1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042299">
        <property type="entry name" value="Ufd1-like_Nn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055417">
        <property type="entry name" value="UFD1_N1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055418">
        <property type="entry name" value="UFD1_N2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12555">
        <property type="entry name" value="UBIQUITIN FUSION DEGRADATON PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12555:SF13">
        <property type="entry name" value="UBIQUITIN RECOGNITION FACTOR IN ER-ASSOCIATED DEGRADATION PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03152">
        <property type="entry name" value="UFD1_N1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24842">
        <property type="entry name" value="UFD1_N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Ubiquitin fusion degradation protein UFD1 N-terminal subdomain 1" evidence="5">
        <location>
            <begin position="10"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin fusion degradation protein UFD1 N-terminal subdomain 2" evidence="6">
        <location>
            <begin position="110"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="186"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="189"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00071119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF24842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAG5097223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="294" mass="33586" checksum="45C526AE17EA7DDC" modified="2022-05-25" version="1" fragment="single">FAFNMFPRPFNTQYKCFSVSMFPGNERQDVERGGKIIMPPSALEQLTRLNIVYPMLFKLTNKKTNRVTHCGVLEFVADEGKVYLPYWMMHNLLLEESEIINIESVSLPVATYARFQPQSEDFLDITNPKAVLENGLRSFACLTTGDIVAIQYNQRIYEMCVLETKPGPAVSIIECDMNVEFAPPVGYKEPQREEKKPQEDQIDPTDLMPESTGFFAFQGQGNRLDGKKRKDSGPSETQVPKPVYVRGIPDYDYKIGTLNFLRNIKSINTTKDEKNTDEFKAFTGEGFSLRKSRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HF93</accession>
    <name>A0A8J2HF93_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Histone H2A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">HICCMSTLAB_LOCUS6494</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5 12">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 12">Belongs to the histone H2A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5092975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HF93"/>
    <dbReference type="OrthoDB" id="7682878at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00074">
        <property type="entry name" value="HFD_H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000020">
        <property type="entry name" value="Histone H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002119">
        <property type="entry name" value="Histone_H2A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032454">
        <property type="entry name" value="Histone_H2A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032458">
        <property type="entry name" value="Histone_H2A_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23430">
        <property type="entry name" value="HISTONE H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16211">
        <property type="entry name" value="Histone_H2A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00620">
        <property type="entry name" value="HISTONEH2A"/>
    </dbReference>
    <dbReference type="SMART" id="SM00414">
        <property type="entry name" value="H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00046">
        <property type="entry name" value="HISTONE_H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0007">Acetylation</keyword>
    <keyword evidence="6 12" id="KW-0158">Chromosome</keyword>
    <keyword evidence="9 12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="11 12" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="10 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="14">
        <location>
            <begin position="11"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="Histone H2A C-terminal" evidence="15">
        <location>
            <begin position="91"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF16211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CAG5092975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="115" mass="12333" checksum="293BDA0D0767697B" modified="2022-05-25" version="1">MSGRGKGGKVKGKSKTRSSRAGLQFPVGRIHRMLRKGNYAERVGAGAPVYLAAVMEYLAAEVLELAGNAARDNKKTRIIPRHLQLAIRNDEELNKLLSGVTIAQGGVLPNIQAVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HGF0</accession>
    <name>A0A8J2HGF0_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Similar to NPAS4: Neuronal PAS domain-containing protein 4 (Homo sapiens)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HICCMSTLAB_LOCUS7689</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5095398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HGF0"/>
    <dbReference type="OrthoDB" id="9978016at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd19697">
        <property type="entry name" value="bHLH-PAS_NPAS4_PASD10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.20:FF:000081">
        <property type="entry name" value="Dysfusion, isoform B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056192">
        <property type="entry name" value="bHLH_NPAS4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23043:SF39">
        <property type="entry name" value="DYSFUSION, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23043">
        <property type="entry name" value="HYPOXIA-INDUCIBLE FACTOR 1 ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23183">
        <property type="entry name" value="bHLH_NPAS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14598">
        <property type="entry name" value="PAS_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="PYP-like sensor domain (PAS domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="8">
        <location>
            <begin position="6"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="7">
        <location>
            <begin position="64"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="578"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="578"/>
            <end position="587"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAG5095398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="611" mass="70023" checksum="E2FAFBA572BC63B6" modified="2022-05-25" version="1">MFNRIDSSKSTKGASKLRRDLINAEIANLRDLLPLPPSTRQRLSQLQLMALVCVFLRKANYFQQGKLLYISENAAEYLGHSMEDLLIHGDSVYDVIDKQDHMVVQNQLARSGPMSSNDKRLFLCRINVSRNSRRQLRFGDQKVVLVEGHYLPFVPLCNRNESVFLASCTPVVLPETRESVVQGATNIFTTIHSMDMKYLHIDKTAESHLEYTRSELVGVSWYNLLHWDCIRTAYCKHQTVIQSDQERTSTALLRLQSRSGRWFWIHCVLQVKETSEECQHPIIVCTNQVLSDKEAEVMRASSWLYQYSSQSKFTYGICPSSNQSSHSSTMSYQESYPRSVLMQPVHPSEASVSSYSLDDNHRARIDAEYPPVPSASTLTKVEVTNQEDIEPVDMSINSSGEHETRTLYQLSHPINIEFPKQVPAHHHHYHQQHQHARMTPKFCGYRGKLAVHYLHGRQYSSVSSAESPKYTDLDSAYGDACAERNSGHKRGGKTNGIMMLDPHETMDQWNSSPIWSDALQRVPDVVHQDLSPMYITTPTTPVDTPDSADLHSEVPVFNFDWTHHEQHVPSSKIMVRKDLEQRQDRDQQPLTLHLPRRKNQTDASSKEYEDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HGI0</accession>
    <name>A0A8J2HGI0_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS8993</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5098019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HGI0"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035163641" evidence="1">
        <location>
            <begin position="16"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5098019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="179" mass="19951" checksum="F3229AE80626FCCB" modified="2022-05-25" version="1">MKVLIFLMLVAAVVAEEEKAPKKRGLFGLGYGYGDYGHGLDHGYYGHDLGHHEHHTVHVKAVPVPYPVPKPYPVHVDRPYPVKVPVDRPYPVPVKVPVPQPYPVIKTKTVHVPVDRPYPVPVKVPVPAPYPVKVPEPHPVPVAVPHPVYIKEKVPVYVHGHGHGHDYGHGFEHGYGHLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HGP6</accession>
    <name>A0A8J2HGP6_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to dyb-1: Dystrobrevin-1 (Caenorhabditis elegans)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS9670</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5100597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HGP6"/>
    <dbReference type="OrthoDB" id="6019271at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099536">
        <property type="term" value="P:synaptic signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015154">
        <property type="entry name" value="EF-hand_dom_typ2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050774">
        <property type="entry name" value="KCMF1/Dystrophin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12268:SF27">
        <property type="entry name" value="DYSTROBREVIN, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12268">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE KCMF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09069">
        <property type="entry name" value="EF-hand_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="2">
        <location>
            <begin position="54"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5100597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="170" mass="19707" checksum="B09855EFAF321AC3" modified="2022-05-25" version="1" fragment="single">YLDSDTPGIPFYYFLLFLNDFYNLIILFLLYREANKITVFSVKVALSTLCAGKLIDKFRYIYSQISDNNGHMIHWKFSEFLKEILSLPAAVYETPSFPYSEDLSNSIIPSDSKVTVNNFLDIFMSDSGPHCLIWLPLYHRIANVESGMEKFFSPLAVSLSEEFNYHLRLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HGT9</accession>
    <name>A0A8J2HGT9_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Dynamin-binding protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Scaffold protein Tuba</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">HICCMSTLAB_LOCUS9963</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell junction</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
            <location evidence="2">Golgi stack</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5100890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HGT9"/>
    <dbReference type="OrthoDB" id="27823at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070161">
        <property type="term" value="C:anchoring junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005795">
        <property type="term" value="C:Golgi stack"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00160">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00174">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004148">
        <property type="entry name" value="BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051492">
        <property type="entry name" value="Dynamin-Rho_GEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001331">
        <property type="entry name" value="GDS_CDC24_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22834">
        <property type="entry name" value="NUCLEAR FUSION PROTEIN FUS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22834:SF20">
        <property type="entry name" value="SH3 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03114">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14604">
        <property type="entry name" value="SH3_9"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00499">
        <property type="entry name" value="P67PHOX"/>
    </dbReference>
    <dbReference type="SMART" id="SM00721">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51021">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00741">
        <property type="entry name" value="DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0965">Cell junction</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="11">
        <location>
            <begin position="2"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="11">
        <location>
            <begin position="66"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="11">
        <location>
            <begin position="136"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="11">
        <location>
            <begin position="284"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="11">
        <location>
            <begin position="367"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="domain" description="DH" evidence="12">
        <location>
            <begin position="517"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="domain" description="BAR" evidence="13">
        <location>
            <begin position="743"/>
            <end position="953"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="228"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="449"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1068"/>
            <end position="1107"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="1143"/>
            <end position="1170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="232"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="263"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="449"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1070"/>
            <end position="1091"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1092"/>
            <end position="1102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00032587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CAG5100890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="1233" mass="139491" checksum="56CC09A969FEC550" modified="2022-05-25" version="1">MEAGLLTKVINDFLTIVDGELSLSKRDYFLVYNVIDKHWCYGESYGRRGRFPSNHLHKIDLPIFKDSEKLFVSIAPFIGEQDGDLTFAEGELIIGVQQVDTDWYSGYTDSRTGLFPLTHVWLIDSSILKKPTDKKKVRRKAKVKTSLKAQLDEELDLTAGEIVTVIEILDDGWVLGVTDDGRQGSFPEGFISYMEEEQDSGVDESDRSSALNIAMDPFPTSVAQGGEIFKDFNQSGPSTSSENANNEPAPSYYDLFPETRPTSVDASSNINNDSDNNGQLNSLGLKPYAITLYPFNAQFPNELNFEAGEVVHLIRHIDSEWAEGEINNQKGIFPTTYVNIIVNCSASDVNQTESNETEQSKDYERLNAGDLVRVQHTFNAQMNGDLSVAEGDVLTVIEMANDDWVSVKNKLGDIGLCPRGYLTRSEESQTPLVKHDSIKDFVVVRDVEKTTETPKEERTKRLSEPHRPAPPAPAPGSIPLQKQSVADKTQLQLEETSTGLVDEINEVEAAKQKRADKRQNVITELVVTEKEFVRDLKVTYETFHLFNPKVLEERGIDVPLLFGNFLEVIHVAEELLDSMLKAMKGCDESKQMISPCFLSIADRLQTVYGKYCGNHEAALSLLTKYEENRDIMTIFEKGIETLRYQVACFDMSSILIKPVQRILKYPLMLYELTKCTEDDHPDRQGIEAAWKAMTDVASHINEYKRRKDIVSKYFDTDNTLMRKMAKLSMHSVAKKSSRLSAKLSASFGLTNVPADPAFEELEKQFKSLAKSVELLAIDIEQCLIWLNDDASCGELLAEFINQYYSGVHDIEVQKYSQVRSMISNQFIKTFKENIDRSVIKPLSSLMVLLEGPEMLITKRHDKLLDYDNAISKNEKNKESRIIQEELTNTKSNYEALNQQLLEELPILIDAGVKITISCVRSFTKARKLFNGKIMKQYLDLPKSTTQHPSEDILQLFLINHNLLWNQISRFSFAGVNPRVEEANIDVSPQNDKQKTQLLRKYQRDKLFVVKDNLISTSTLDLGASKGTIVAVIKTQDPMGDSSRWFVDNGITQGFMPSKMLESLSQMSFYSNSSSNNNNNNNNNNNNNNNNNDVVDSRSNTPDLMSLESPVKNVNTNLISLESPQKESSSRSNSNSQSQWYLNVDQVNNDNKNYENLSSKQEQRYENFDSKFYYAEYDFDGNLPGTLAVKKGQALKLIRPNDEKGNTAWWLMETREGKSGYVYISTKSSILIDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HHX6</accession>
    <name>A0A8J2HHX6_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">arginase</fullName>
            <ecNumber evidence="3">3.5.3.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">HICCMSTLAB_LOCUS10670</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-arginine + H2O = urea + L-ornithine</text>
            <dbReference type="Rhea" id="RHEA:20569"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16199"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
            <dbReference type="EC" id="3.5.3.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Nitrogen metabolism; urea cycle; L-ornithine and urea from L-arginine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11 12">Belongs to the arginase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.3.1" evidence="3"/>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5101769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HHX6"/>
    <dbReference type="OrthoDB" id="9992747at2759"/>
    <dbReference type="UniPathway" id="UPA00158">
        <property type="reaction ID" value="UER00270"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004053">
        <property type="term" value="F:arginase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004333">
        <property type="term" value="F:fumarate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006106">
        <property type="term" value="P:fumarate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010121">
        <property type="term" value="P:L-arginine catabolic process to proline via ornithine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006108">
        <property type="term" value="P:malate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000050">
        <property type="term" value="P:urea cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd09989">
        <property type="entry name" value="Arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.800.10:FF:000005">
        <property type="entry name" value="Arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.40.30:FF:000002">
        <property type="entry name" value="Fumarate hydratase class II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.40.30">
        <property type="entry name" value="Fumarase/aspartase (C-terminal domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.200.10">
        <property type="entry name" value="Fumarase/aspartase (Central domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.10">
        <property type="entry name" value="Ureohydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014033">
        <property type="entry name" value="Arginase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005677">
        <property type="entry name" value="Fum_hydII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018951">
        <property type="entry name" value="Fumarase_C_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020557">
        <property type="entry name" value="Fumarate_lyase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022761">
        <property type="entry name" value="Fumarate_lyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008948">
        <property type="entry name" value="L-Aspartase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006035">
        <property type="entry name" value="Ureohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020855">
        <property type="entry name" value="Ureohydrolase_Mn_BS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01229">
        <property type="entry name" value="rocF_arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11444">
        <property type="entry name" value="ASPARTATEAMMONIA/ARGININOSUCCINATE/ADENYLOSUCCINATE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11444:SF1">
        <property type="entry name" value="FUMARATE HYDRATASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00491">
        <property type="entry name" value="Arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10415">
        <property type="entry name" value="FumaraseC_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00206">
        <property type="entry name" value="Lyase_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00116">
        <property type="entry name" value="ARGINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="Arginase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48557">
        <property type="entry name" value="L-aspartase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01053">
        <property type="entry name" value="ARGINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51409">
        <property type="entry name" value="ARGINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00163">
        <property type="entry name" value="FUMARATE_LYASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0056">Arginine metabolism</keyword>
    <keyword evidence="7 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-0464">Manganese</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0835">Urea cycle</keyword>
    <feature type="domain" description="Fumarate lyase N-terminal" evidence="13">
        <location>
            <begin position="33"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="Fumarate lyase N-terminal" evidence="13">
        <location>
            <begin position="134"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="Fumarase C C-terminal" evidence="14">
        <location>
            <begin position="245"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022503"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF10415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CAG5101769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="644" mass="70181" checksum="D91461DC3456F420" modified="2022-05-25" version="1">MVIQRNHKRMANNESLRPTRSLNLKNVTHVYNNQILLPGLTQLHAALKAKADAWKDIIKIGRTHTQDAVPLTLGQEFSAYATQVEYGIARVKDTLPRLYQLALGGTAVGTGLNTRKGFAEKTAARIASLTGYPFLGSGPRCGLGELSLPENEPGSSIMPGKVNPTQCEAITMVCAQVMGNHVATTIGGSNGHFELNVFKPVMVANTLRSARLLGDSAAAFTKNCVVGIEPNIDNIKKIMNESLMLVTALNPHIGYDKAAAIAKQAHKQKLTLKESALKNGLTEEQFNQWVRPEQMLGPKTKNCSRLLQECKCILKQTITVRNYRKVGIIGVPFDKGQKKQGVELGPDAIRKAGLIQGLENIGLDVKDYGDVKYEIKSKEGIDNMDHLNEVAACTYKVSEIFEKVLKDGRTPVTLGGDHSLTVGTVDAHVKSKGSNNVVLLWVDAHADLNTNKTSSSGNAHGMPVALIASELSDYWPHLPGMDWQKPMLSIRNIAYIGLRSVDMYERLVIEKFGITAFGIDDVERLGIHQVINMALEKLDPHSEKSIHVTFDIDALDPLEAPSTGTSVRGGLTIREGIHLLEQVYRTGRLNAIELVEVNPLLSDTKGVELTAGAAVLLLQAALGNNRRGLRVPEGITDMPLQTFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HIE9</accession>
    <name>A0A8J2HIE9_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Polynucleotide 5'-hydroxyl-kinase NOL9</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">HICCMSTLAB_LOCUS9952</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Clp1 family. NOL9/GRC3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5100879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HIE9"/>
    <dbReference type="OrthoDB" id="2405412at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051731">
        <property type="term" value="F:polynucleotide 5'-hydroxyl-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000448">
        <property type="term" value="P:cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045116">
        <property type="entry name" value="Clp1/Grc3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032319">
        <property type="entry name" value="CLP1_P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057570">
        <property type="entry name" value="NOL9_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057573">
        <property type="entry name" value="NOL9_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12755">
        <property type="entry name" value="CLEAVAGE/POLYADENYLATION FACTOR IA SUBUNIT CLP1P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12755:SF3">
        <property type="entry name" value="POLYNUCLEOTIDE 5'-HYDROXYL-KINASE NOL9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16575">
        <property type="entry name" value="CLP1_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24419">
        <property type="entry name" value="Cupin_NOL9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25467">
        <property type="entry name" value="NOL9_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NOL9 N-terminal" evidence="12">
        <location>
            <begin position="191"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="domain" description="Clp1 P-loop" evidence="11">
        <location>
            <begin position="387"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="domain" description="NOL9 C-terminal" evidence="13">
        <location>
            <begin position="621"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="134"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="134"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="155"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00071212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF16575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF24419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF25467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CAG5100879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="770" mass="86737" checksum="CC7BE1C415552225" modified="2022-05-25" version="1">MSKIKSATSNKDNLSDESINGCITVDDSSSEDIQIVYSDESPSDCIPIKNFVNHLQDSCNVPPKKVVKNKFKSPITIKTNLMKPLPNILRHSWSAGYKIPRRKTKIPREFEFNESNLNVTIGPSIIPESVIKKRETKSDKQNHESSSESQYEVDTSTDSDELDNTIDTNTSVLDESIPNLDDSVSSDDKTSLHFYCLRNKVICALNAHKHFSFHGKLKIKVLYGAVEIYGYTLNKSNTITPVEIYSPRSSNLLRIQSACSSESSDLDDLSVAWDALKEDNIDCNSEAFTTFVDNIQPGWSVFTLQNFDNNLTDFIERHFSHRLFPTFESSTNNCWTQLRRAEIILQSYIFPTKARKRVISFNNTKETVETVVNDFISRNSSRIILAGAKNLGKSTTTRYLVNKLLQKTEQVIVLDFDPGQSEFTPAGCVSMSIVRKPLLGPNFTHLERPFYQFYIGGIDVTRCLTNYIEGIKKIIECSNNYLDKHNNSVPVIVNTMGFCKDLGWDIMCYIIKSIEPTDVIQINSKKTKCNYDNLLQHQVVINEKSSGLSWTSVDNTSLNEYKHYLVYSDAEFRGKSGETWNIEPHQLRDIAMLAYLSDITKVINNTKSYFTSTSIPATINEITPYQISFSSVKISLGFPVVSHVLSVINGNIVALCGTDFDDDQCDTEKVSYPKVLVRAPLATCYGFGIVRGIDMEQEKIFLNTPLSVDELKYVNCLIGSIQVPAGLRQLNKSGLPYTSGECNLPTSRDPRRGCFHMKNLKDTSLLSIDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HIT2</accession>
    <name>A0A8J2HIT2_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transformer</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS8583</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5097183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HIT2"/>
    <dbReference type="OrthoDB" id="8194777at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022063">
        <property type="entry name" value="Sex_determin_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12278">
        <property type="entry name" value="SDP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Complementary sex determination N-terminal" evidence="2">
        <location>
            <begin position="106"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="238"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="439"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="247"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="268"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="287"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="307"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="337"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="369"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="447"/>
            <end position="460"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5097183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="460" mass="54066" checksum="0A2255DD7801FB63" modified="2022-05-25" version="1">MAAMCLDMRRARKNDLRSRNASSHPSGSGHHPSDYAEEEKQRRRHEWMLEQEKKREHERRKQIMIQQYEARRAHELALRNAHRSSHRARTRSQSRSRSFSSSRSRERKRTPSRSRSRNKSTRNRDRSRSRSSRSRSSDHSRKQRVRCNVSKTLVMAKSAPVFKGPEISPIPLADLKKIKIDIHRQIPTTVPQPEKLERDILNPEDIVVARKDGEGIIPIFDRPELKTTGISTPEVKELRTIISVQNGKRRSSRRRSSSSSSSRHRRSPSSNRRSSSSSPRHRRSRSPRRESRYKSSRYEKKSRHNSKYREHSRDRKNDDKPRSRDRHRLSEAGSRDNRRHGSSSRGHGSRHRSTSRDRDRRHSSHRIAHNYDRYESHSSRRVPPYMKPLQFPYYFADYMRPIVIDPVMAMRAPMPYVRGRMPPMMGMGGPIRPNFPRFGPPEMIRPYGPPGPPHSRPGRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HIZ2</accession>
    <name>A0A8J2HIZ2_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS10057</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5100984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HIZ2"/>
    <dbReference type="OrthoDB" id="5822793at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="180"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="409"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="559"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="717"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="769"/>
            <end position="928"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="957"/>
            <end position="977"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1000"/>
            <end position="1161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="193"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="427"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="466"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="487"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="559"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="570"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="782"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="820"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="871"/>
            <end position="880"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="901"/>
            <end position="921"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1014"/>
            <end position="1030"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1136"/>
            <end position="1146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1150"/>
            <end position="1161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5100984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="1188" mass="132796" checksum="D35FF3E9CC41162A" modified="2022-05-25" version="1">MEITNEGHQEFNDDTPVLTAQITNTGHDNGIANLEVVQDTSKSLLAKCHSNQQPEDREIKIEDVNNGESRIERDSLEKETDSVKTVKSPSSLAFTIDFGGNKEVDSAKYQNLFQRYNARHKRNLSTSKIEIKSKPVADSSPNCLQKHKPVSIHSEGYFSSEDDTKRKADRLSQKLKELGLKNTKGATKKSDLMSRSMTENTNGDTKRRSYHEESTNNCVYEITYSATMNDLSKMQSNVEEELNRVQYSPEKKYTKNIEYIEINHDYGEEVEKSSLDTVEKLSNTSYMSDNCPSNEFASSSSRQTNVQMMSVSYTGESSGDYDQTNLEVFNVSTVDAGSDGTVSEAGTYTIHKDYTDEEKARMDIDKTFSVGVLTEEESNELYVHHFKMRSSRDTNTWITEWATQVAEHNSLPPVIGGTTGRTPPMSPSKIPSPIYSRTQRASRTRYEQSDSSLDAEIQQMRDRITSVPNSNQHTLIDSGGESDEDTSNSYNTPPHSSQRTPTHSALVRRGSLSESLFKRVNHNDCRRSMRKYPEIKKKEEILDVPKSPSHVLARLHLERGNSLDRKSDTAESNSSRRSSLKNYTTDDNFKHTNSPILNRLRTNNSTTPKLTNSPILGHKTITTKILNSPSFERPKQLLVKSNSQAKNVGYFTCVENSPYMLRKSNSTSNYREDTSPGIKELSVLNSNSIYQRNSVGIQRSSSNTSIRIAKTKNMLARRSSFNDQGDRLSKTKHVVSDSSSEAGETHNIPAPPISSGIKLNRAFSIRRARVTCDSDTTPNTTPEERRRKAQMEIKSAPSSARQSSSHHRARTSSVGANNKDNYKKPETRPRVPSLSRNEGGRYSMRGQKSTSSASTSRPNSGVKGGKDAKNSGRSNSTLTSKEVEFQNWKRRKNYDPMKAAAEGKKKLDISRKHHSTEDGNNSRDNSVLRSASFHGTHGALSLADDWSDNELNFVEQKEIIQIPPPCSPRDSDSDLDTSSYLQTTQNVMSAMSARITVYQPAPVDSGGESDEDTSQSLRQTNKISHQVSDTESSDDPHPVGSKFNRSYGLRKSRESQEVKSAPIKTRTPVVNSKPRAETASIARTDSGRFSMRTKGSTTGPKAKPKDVKKQSQSITREQEMQNWKRRKSYDPMKAAMEGKRKAELAKKNLSSESSSVLRSQSFHGPVNFGISEWSDEDISASADEAPIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HJ46</accession>
    <name>A0A8J2HJ46_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Similar to MBD3: Methyl-CpG-binding domain protein 3 (Homo sapiens)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HICCMSTLAB_LOCUS9398</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5100128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HJ46"/>
    <dbReference type="OrthoDB" id="10072024at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032343">
        <property type="entry name" value="MBD2/MBD3_p55-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025884">
        <property type="entry name" value="MeCpG-bd_2/3_C_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14048">
        <property type="entry name" value="MBD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16564">
        <property type="entry name" value="MBDa"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyl-CpG-binding" evidence="3">
        <location>
            <begin position="40"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="Methyl-CpG-binding" evidence="3">
        <location>
            <begin position="98"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="Methyl-CpG binding protein 2/3 C-terminal" evidence="2">
        <location>
            <begin position="128"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG5100128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="201" mass="22525" checksum="441A4A30A2713632" modified="2022-05-25" version="1">MNMSIDKKKYSSTLPTNWPTRDEIPRKNSNPLPPSSGKVDVYYYSRGVRNDASLVPPIRQTASIFKQPVTIYKTQDRKVSKDVKHGAQDKPKQEGTDKTDSKYCSQDKPKQLFWEKRLEGLRACDPDGYEFNGMDLPKTLKPVGPYITEETLLQSVATALHMSSQPVTGQTGSKTSLEKNPGVFLNPDQPLVQFIICGNDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HJ98</accession>
    <name>A0A8J2HJ98_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Similar to RF_0381: Putative ankyrin repeat protein RF_0381 (Rickettsia felis (Strain ATCC VR-1525 / URRWXCal2))</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HICCMSTLAB_LOCUS10132</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5101059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HJ98"/>
    <dbReference type="OrthoDB" id="194358at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="104"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="137"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="172"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG5101059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="448" mass="52019" checksum="EC71B2285EAA72A9" modified="2022-05-25" version="1">MEQRREIDNYKKFKKLKVLDKRNYDEVCGEVKAGRLSKDVELQIRVQCYYFFLKNDFNLLEMHNQPFIGTVTMSIIHVAIGLNDQEMIDHLLALNCNLQATTGYGNSVLQWAVMCNKLTTVEKLLDTGVDINDIGEDHQLLLAIAVSWNRYEVVELLISRGAQINDRKSCTFNKSPFGCAVFESNVNMMKLLISHGADVNLAVSHMKSHWTCTPLIAACSFDNSTDSIEFLLNHPYIDIQAVHESNETCVFFAARNDPLGYLQLILNTNIDINTKNIYNKLPLDVVWDGNNNVINRHIVKLIVAGFYVCEENREAVRDRKFDKLRAECSKEIQLMKDTKELYTNWSCFTILMRSQHFLALRFKHVEVSVDQEEEWIKKFPLYGKILAFHLKKALQRKMILKRTDQVLFDIFYKILPDTFIHDLYHFFSNYNLSKLLDYFTCSENASSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HKD0</accession>
    <name>A0A8J2HKD0_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS9174</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5099667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HKD0"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5099667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="132" mass="15222" checksum="B4AEA7E296E23083" modified="2022-05-25" version="1">MLLLIPVGSIWNQADKLVLDFHQEEQHILIIRLSNSIFIIDDNFRHKKGVHLFLCEDYEILMIISLMPIAMVITTIVMIYLIKLVVKWTYRLLDRVSDIKKELASKVIVTPALTLESNLKGSVTSELCTEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HKJ8</accession>
    <name>A0A8J2HKJ8_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Similar to Hsf: Heat shock factor protein (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HICCMSTLAB_LOCUS7505</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the HSF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5095030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HKJ8"/>
    <dbReference type="OrthoDB" id="60033at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000027">
        <property type="entry name" value="Heat shock transcription factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000232">
        <property type="entry name" value="HSF_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10015:SF427">
        <property type="entry name" value="HEAT SHOCK FACTOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10015">
        <property type="entry name" value="HEAT SHOCK TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00447">
        <property type="entry name" value="HSF_DNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00056">
        <property type="entry name" value="HSFDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00415">
        <property type="entry name" value="HSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0346">Stress response</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HSF-type DNA-binding" evidence="9">
        <location>
            <begin position="10"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="468"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="468"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="484"/>
            <end position="494"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAG5095030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="652" mass="73079" checksum="C027DBD1BB4097E2" modified="2022-05-25" version="1">MHTVMEVETSVPAFLGKLWKLVEDPETDDLICWAPNGRSFFIRNPAQFARELLPHYYKHNNMASFVRQLNMYGFHKKVSVELGGLKCERDEMEFAHQYFIKDHPYLLEHIKRKIASSKSQDGHPPIKTEVMNKVLSEVRSMRGRQEHMDTRLGAMKRENEALWRELAMLRRKHLKQQEIVNKLIHFLVTLVQPSRSGGLPVKRRYPLMIDNHQRSKQMKVDKLIPEASPTGPVIHELDATEHEHHVDDLNSEYIVAEMLENHNASVQSPESIATLNDEHIETVHFSPNAPISNDPSEIQETSAKKKIVLKPKKKRKNTVPVKILIPSTNIGEEPRLEETLMLEVNPEDIQAPTQVEKATTKLQKKPVPIKTVRSSKLTAMAANINKMNDSSELDEDSDEVDNDLKEAPEIAVESNNVDLGDMLIIPDILLNPDGSIIDMNKSGEFQGDTHKEENSSADKLKQQVLEATQQQRTAVSSNNGDPGSSSKSNNLSLSCVSPSNMSSTAYRLGSMEEMDSHLEAMHNDLENLREMLHNEGYTIDANTLMELFGSNDPMSFGIPVNPELNPTHHDKDQDPVDANGATGGELMAYTPSSFIDFDDDMLLAANNLGAENVDGQNITNEFYNTDSLDLEDSKASLLDSLVSGNGNSSANL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HL50</accession>
    <name>A0A8J2HL50_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Cc_fen1_3b</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS7928</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5095878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HL50"/>
    <dbReference type="OrthoDB" id="432905at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5095878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="369" mass="43089" checksum="F60CEA1B1C0D52C3" modified="2022-05-25" version="1">MGINHGYDVCDFFLTNSELRNNSTNPKLKCNIYIDGYVLWRSGTIPGTDLIDENIVEGNIEGIRQYIMSTGNFDVQSTFIYFDGQPPKLKRSDNLGFIYPDSQLGRWIEKVRGSGYPGEIVLLEKGEAEIQCFLQRDRSIASIICTSDSDALHICYNDNSQRRSDRVFFYRLNYQHRECEKLYDTNLFTTKFNKNAFTLLLYLLGDKNYIKSLFTPSMVKKIFELLNEPTYADIFNRINTTMNELKLNIDNIEKCIAFFIRLLCDARKNKISQGKKRDTVSWPQSNTIMSTGNYIHVLRWMIMYSSMGSNVEYYDNFELIEPVGVEEITNLKYIYRLCVRVFPLDDNVIQDFKKEIEHHMNNVAIDRLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HLT4</accession>
    <name>A0A8J2HLT4_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS11464</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5103347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HLT4"/>
    <dbReference type="OrthoDB" id="6514900at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5103347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="117" mass="13130" checksum="965DA517E1E34D30" modified="2022-05-25" version="1" fragment="single">MESFHKLCFFKTVIVVIVICTIVIDVQARSIGGVLSRRKRVSDQRLAELETLLALARMRGKLVTVPVGFGRVDPAKIGRRRRSSIEYDLQKLQRILQTVVNDSESGSEENDDISSSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HM47</accession>
    <name>A0A8J2HM47_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS11138</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5102696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HM47"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="24"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5102696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="72" mass="7254" checksum="075DF115025CD39B" modified="2022-05-25" version="1">MLKHVSISPWRGRSDSVSLASSNGDTSSCGSGSPTPSHTPPPSRASSCASLVPLTALSSFSPADTAPQQIVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HMB6</accession>
    <name>A0A8J2HMB6_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">S-adenosylmethionine sensor upstream of mTORC1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Probable methyltransferase BMT2 homolog</fullName>
            <ecNumber evidence="4">2.1.1.-</ecNumber>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HICCMSTLAB_LOCUS11547</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="4">S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling. Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1. Probably also acts as a S-adenosyl-L-methionine-dependent methyltransferase.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the BMT2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="4"/>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5103513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HMB6"/>
    <dbReference type="OrthoDB" id="5954793at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904262">
        <property type="term" value="P:negative regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03044">
        <property type="entry name" value="BMT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021867">
        <property type="entry name" value="Bmt2/SAMTOR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21008:SF0">
        <property type="entry name" value="S-ADENOSYLMETHIONINE SENSOR UPSTREAM OF MTORC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21008">
        <property type="entry name" value="S-ADENOSYLMETHIONINE SENSOR UPSTREAM OF MTORC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11968">
        <property type="entry name" value="Bmt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="4">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="154"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAG5103513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="345" mass="40256" checksum="9DD95DC47A168CD4" modified="2022-05-25" version="1">MASEEHKKLAALIKETHNRLREDYRKYGSNEAWKRHLARTDDLQNYAVSMQQLATNHWSINNNIKQVTDKSNCRIRWIKNRCYEYFFGGGKSKYYERERDIIKKLNLDDLNDLPEESLSKDNKVVNERKIKMLDVGSCYNPFADDENLDVTAIDLVPASDQVFQCDFLNVNLGDETLLSKDNKSVIEFEKKSFDVCIFSLLLEYFPCPEQRFRCCEKAYELLKDSGLLIIITPDSKHVNANAKIMKSWRYVLANLGFMRITYEKLQHIHCICYRRCVKKDTAVRWVTLQKNLSVDDVLFNSNGKIFIPQDFQTVCVEDKDKASNVKVAKEDLADVFNELPDVIDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HNI3</accession>
    <name>A0A8J2HNI3_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HICCMSTLAB_LOCUS10910</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5102228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HNI3"/>
    <dbReference type="OrthoDB" id="9982946at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042060">
        <property type="term" value="P:wound healing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055470">
        <property type="entry name" value="DUF7042"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055471">
        <property type="entry name" value="DUF7043"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22255:SF1">
        <property type="entry name" value="LD32918P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22255">
        <property type="entry name" value="LP06548P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23069">
        <property type="entry name" value="DUF7042"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23070">
        <property type="entry name" value="DUF7043"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="391"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7042" evidence="2">
        <location>
            <begin position="4"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7043" evidence="3">
        <location>
            <begin position="85"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7042" evidence="2">
        <location>
            <begin position="207"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG5102228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="414" mass="47883" checksum="51F1C2CEE6FE8FD8" modified="2022-05-25" version="1">MKGTFDGVVEYSCLGDWFVGKNHFFAVANTKESRKDEKYRCFLKNREDDLYIGVSITAECNTLNTVEKSPERLHITPVKAEVVIPGCRLPQNMSGDWINTANNDADVFINETHIIEEWHPDEGRYRRTIYVCQEQRDSRIMMARLTVDGCQKDYVCFDFIPRHHNIIRFRKGLAVIKNNFHTVCSWVQFPGQIKWKYDLLLAKYPVPVRCPVAGKFAFKQAGDILFETRILGGVTLAPRPNTYCKANISDFSVCDSDQKEIAIDETYCLSVDHLGRPVDIYSDPDYQMKCIGYYKENLKSYLITFDELDPYSKYRCWVYQRAELNRILMSQAVGPYCSVNQTVKSWNWTEGAAVAIDMTEYERERDQCPMFFDDGTNPWLLSESHIRIFRFGSSAVCNTPSILLFVALLLTIFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HNL6</accession>
    <name>A0A8J2HNL6_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Similar to NPC2: NPC intracellular cholesterol transporter 2 (Bos taurus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HICCMSTLAB_LOCUS12837</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NPC2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5107625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HNL6"/>
    <dbReference type="OrthoDB" id="6332846at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032934">
        <property type="term" value="F:sterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015918">
        <property type="term" value="P:sterol transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.770:FF:000001">
        <property type="entry name" value="NPC intracellular cholesterol transporter 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003172">
        <property type="entry name" value="ML_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039670">
        <property type="entry name" value="NPC2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11306">
        <property type="entry name" value="NIEMANN PICK TYPE C2 PROTEIN NPC2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11306:SF68">
        <property type="entry name" value="NPC INTRACELLULAR CHOLESTEROL TRANSPORTER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02221">
        <property type="entry name" value="E1_DerP2_DerF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00737">
        <property type="entry name" value="ML"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035202718" evidence="4">
        <location>
            <begin position="22"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="MD-2-related lipid-recognition" evidence="5">
        <location>
            <begin position="23"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAG5107625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="159" mass="17669" checksum="9B4FC66F2D3027DD" modified="2022-05-25" version="1">MSRAIFIVIFALTCLTFLTEAVPKTPDSSSNIQSLTITNCNVPPCPLKKGNIVSVEEVFSVNKDISKLKTKVSANVLGLNLPFIGVDDYDACPNIYNMDDTKSGCPLSAGGIYKYKNSFKIQGFYPNIKTTVYWKLVEELNQRKSNVITCFQVDAQIKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HNW6</accession>
    <name>A0A8J2HNW6_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Similar to thoc7: THO complex subunit 7 homolog (Xenopus tropicalis)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HICCMSTLAB_LOCUS9974</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the THOC7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5100901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HNW6"/>
    <dbReference type="OrthoDB" id="205166at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000445">
        <property type="term" value="C:THO complex part of transcription export complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008501">
        <property type="entry name" value="THOC7/Mft1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23405">
        <property type="entry name" value="MAINTENANCE OF KILLER 16 MAK16 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23405:SF5">
        <property type="entry name" value="THO COMPLEX SUBUNIT 7 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05615">
        <property type="entry name" value="THOC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="73"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAG5100901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="202" mass="23646" checksum="EF2D0AB24ECAC38A" modified="2022-05-25" version="1">MSDEEVIRRRLLVDGDGIGDDRRINMLLKSFVKWANNPDVDTTLHKRILASLAQCEFAQKKSHFMSSMSQDELKNYKKLYDDIGTEIEQAKQDIETTKAELQEAKQIRKNRIEYDVLAKVINEQPDRKKTNLKLETLNQELGFLKEKSEQLEHKLEMRRKQFHVLISSIHSLQEMLDESDEEIMDVSLENYEDNDVAMQVSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HPA8</accession>
    <name>A0A8J2HPA8_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to ARL14EP: ARL14 effector protein (Bos taurus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS11491</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5103401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HPA8"/>
    <dbReference type="OrthoDB" id="5984406at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029264">
        <property type="entry name" value="ARF7EP_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46536:SF3">
        <property type="entry name" value="ARF7 EFFECTOR PROTEIN C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46536">
        <property type="entry name" value="ARL14 EFFECTOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14949">
        <property type="entry name" value="ARF7EP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ARF7 effector protein C-terminal" evidence="2">
        <location>
            <begin position="28"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5103401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="129" mass="14719" checksum="3C7D2A31C822391C" modified="2022-05-25" version="1">MDSDDTNSSKKRNTRYASKQTIGTDTVTKKFLQNFDPQSSEREKRKLHRRLYPGSKKHILYDESGVFIQTGTNICDCLQPDCSGCHFPCPKCGSSKCAHECRTHRRWTYDSIENEGSDIILKNPVAKDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HQM9</accession>
    <name>A0A8J2HQM9_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Similar to LamC: Lamin-C (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HICCMSTLAB_LOCUS14079</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001711">
        <property type="protein sequence ID" value="CAG5110229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HQM9"/>
    <dbReference type="OrthoDB" id="102442at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005882">
        <property type="term" value="C:intermediate filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005652">
        <property type="term" value="C:nuclear lamina"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031507">
        <property type="term" value="P:heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006998">
        <property type="term" value="P:nuclear envelope organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007097">
        <property type="term" value="P:nuclear migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051664">
        <property type="term" value="P:nuclear pore localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090435">
        <property type="term" value="P:protein localization to nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1160">
        <property type="entry name" value="Vasodilator-stimulated phosphoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039008">
        <property type="entry name" value="IF_rod_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45721">
        <property type="entry name" value="LAMIN DM0-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45721:SF11">
        <property type="entry name" value="LAMIN DM0-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00038">
        <property type="entry name" value="Filament"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64593">
        <property type="entry name" value="Intermediate filament protein, coiled coil region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51842">
        <property type="entry name" value="IF_ROD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0403">Intermediate filament</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IF rod" evidence="5">
        <location>
            <begin position="78"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="26"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="82"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="32"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="44"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAG5110229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="154" mass="17386" checksum="71D751BC9AE0D2A5" modified="2022-05-25" version="1" fragment="single">MASCTGLDFCFRVVFISNVKYKVKMSTKSSKKSTASSAAASSSINMSNVQSPQPSTSTPIGRRPGSPLSPTRYSRLQEKHDLQNLNDRLACYIEKVRHLETENSRLTREVQTKEEVVTREVSNIKSMYEHELSDARKLLDETAKERAKLEIDTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HS78</accession>
    <name>A0A8J2HS78_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="21">Sodium/potassium-transporting ATPase subunit alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">HICCMSTLAB_LOCUS12361</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="19">This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients.</text>
    </comment>
    <comment type="subunit">
        <text evidence="20">The sodium/potassium-transporting ATPase is composed of a catalytic alpha subunit, an auxiliary non-catalytic beta subunit and an additional regulatory subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 21">Cell membrane</location>
            <topology evidence="1 21">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 21">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIC subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="24">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5106641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HS78"/>
    <dbReference type="OrthoDB" id="158672at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090533">
        <property type="term" value="C:cation-transporting ATPase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098797">
        <property type="term" value="C:plasma membrane protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005391">
        <property type="term" value="F:P-type sodium:potassium-exchanging transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006825">
        <property type="term" value="P:copper ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030007">
        <property type="term" value="P:intracellular potassium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006883">
        <property type="term" value="P:intracellular sodium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990573">
        <property type="term" value="P:potassium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902600">
        <property type="term" value="P:proton transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036376">
        <property type="term" value="P:sodium ion export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02608">
        <property type="entry name" value="P-type_ATPase_Na-K_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000144">
        <property type="entry name" value="copper-transporting ATPase 1 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1110.10:FF:000038">
        <property type="entry name" value="Sodium/potassium-transporting ATPase subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000003">
        <property type="entry name" value="Sodium/potassium-transporting ATPase subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000001">
        <property type="entry name" value="Sodium/potassium-transporting ATPase subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1110.10:FF:000095">
        <property type="entry name" value="Sodium/potassium-transporting ATPase subunit alpha-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006068">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050510">
        <property type="entry name" value="Cation_transp_ATPase_P-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005775">
        <property type="entry name" value="P-type_ATPase_IIC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01106">
        <property type="entry name" value="ATPase-IIC_X-K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43294">
        <property type="entry name" value="SODIUM/POTASSIUM-TRANSPORTING ATPASE SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43294:SF13">
        <property type="entry name" value="SODIUM_POTASSIUM-TRANSPORTING ATPASE SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00689">
        <property type="entry name" value="Cation_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00121">
        <property type="entry name" value="NAKATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00831">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 21" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="16" id="KW-0186">Copper</keyword>
    <keyword evidence="11" id="KW-0187">Copper transport</keyword>
    <keyword evidence="17 21" id="KW-0406">Ion transport</keyword>
    <keyword evidence="18 21" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 21" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 21" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13 21" id="KW-0630">Potassium</keyword>
    <keyword evidence="5 21" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0915">Sodium</keyword>
    <keyword evidence="7" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="7" id="KW-0740">Sodium/potassium transport</keyword>
    <keyword evidence="14" id="KW-1278">Translocase</keyword>
    <keyword evidence="8 21" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="15 21" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 21" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="103"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="137"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="298"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="328"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="836"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="896"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="935"/>
            <end position="956"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="968"/>
            <end position="984"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase N-terminal" evidence="23">
        <location>
            <begin position="49"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="222"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="24">
        <location>
            <position position="1006"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00037422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00038795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="RuleBase" id="RU362084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="SMART" id="SM00831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="CAG5106641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="1006" mass="111801" checksum="977A91A019049C54" modified="2022-05-25" version="1" fragment="single">HGRTDSYRVATLPNVRDDNKTADGMYKSRRKAPKKKGDLDDLKQELDIDFHKITIEELYQRFQTHPENGLSHAKAKENLLRDGPNALTPPRTTPEWVKFCKNLFGGFALLLWIGAFLCFVAYGIQASTSEEPNDDNLYLGIVLAAVVIVTGIFSYYQESKSSKIMESFKNMVPQFATVLREGEKLTLRAEDLVLGDVVEVKFGDRIPADIRVIESRGFKVDNSSLTGESEPQSRSPEFTNENPLETKNLAFFSTNAVEGTAKGVVICCGDNTVMGRIAGLASGLDTGETPIAKEIHHFIHLITGVAVFLGVTFFLIAFILGYHWLDAVIFLIGIIVANVPEGLLATVTVCLTLTAKRMASKNCLVKNLEAVETLGSTSTICSDKTGTLTQNRMTVAHMWFDNQIIEADTTENQSGVQYDRTSPGFKALAKIATLCNRAEFKPGQEGEPILQREVNGDASEAALLKCMELALGDVMGVRKRNKKVCEVPFNSTNKYQVSIHESEDTNDPRYLLVMKGAPERILDRCTTIFIGGKEKVLDEEMKEAFNNAYLELGGLGERVLGFCDYVLPSDKYPVGFKFNSDDPNFPTENLRFVGLMSMIDPPRAAVPDAVAKCRSAGIKVIMVTGDHPITAKAIAKSVGIISEGNETIEDIAQRLNIPVSEVNPREAKAAVVHGGELRDLDSDQLDEILRYHTEIVFARDGVNDSPALKKADIGVAMGISGSDVSKQAADMILLDDNFASIVTGVEEGRLIFDNLKKSIAYTLTSNIPEISPFLAFILCDIPLPLGTVTILCIDLGTDMVPAISLAYEQAESDIMKRQPRNPFTDKLVNERLISMAYGQIGMIQAAAGFFVYFVIMAENGFLPRDLFGIRKMWDSKAINDLKDSYGQEWTYKDRKALEFTCHTAFFVSIVIVQWADLIVCKTRRNSIVHQGMRNWALNFGIVFETALAAFLSYTPGMDKGLRMYPLKFVWWLPAIPFMLAIFIYDETRRFYLRRNPGGWLEQETYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HTA3</accession>
    <name>A0A8J2HTA3_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Kainate 5 (Rattus norvegicus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS12983</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5107929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HTA3"/>
    <dbReference type="OrthoDB" id="7700339at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5107929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="61" mass="6552" checksum="065409F9F6F243EC" modified="2022-05-25" version="1" fragment="single">GVFVVLLCGLALAILVAILEFCWNSKKNTQSDRQEAGALPMTEMKKSLSFDHVGTCHGGNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HU12</accession>
    <name>A0A8J2HU12_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Similar to AGAP004871: Band 7 protein AGAP004871 (Anopheles gambiae)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HICCMSTLAB_LOCUS13558</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the band 7/mec-2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5108922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HU12"/>
    <dbReference type="OrthoDB" id="2105077at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.479.30:FF:000026">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2090">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.30">
        <property type="entry name" value="Band 7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043202">
        <property type="entry name" value="Band-7_stomatin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001107">
        <property type="entry name" value="Band_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036013">
        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018080">
        <property type="entry name" value="Band_7/stomatin-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001972">
        <property type="entry name" value="Stomatin_HflK_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10264">
        <property type="entry name" value="BAND 7 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10264:SF127">
        <property type="entry name" value="PODOCIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01145">
        <property type="entry name" value="Band_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00721">
        <property type="entry name" value="STOMATIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00244">
        <property type="entry name" value="PHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117892">
        <property type="entry name" value="Band 7/SPFH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01270">
        <property type="entry name" value="BAND_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="47"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="domain" description="Band 7" evidence="5">
        <location>
            <begin position="66"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAG5108922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="302" mass="33308" checksum="D69338971BA09A64" modified="2022-05-25" version="1">MSIQMTTVGNGNNSMTPVVVNSRPDDIRKRVIGADTQTADLTRCGNILIGLSWVLVILTMPFSLFICFKVVQEYERAVIFRLGRLLSGGAKGPGIFFILPCIDAYARVDLRTRTYDIPPQEVLTKDSVTVSVDAVVYYRVNNATISIANVENAHHSTRLLAQTTLRNTMGTRPLHEILSERETISGNMQASLDEATDTWGIKVERVEIKDVRLPVQLQRAMAAEAEAAREARAKVIAAEGEQKASRALREASEVIGDSPAALQLRYLQTLNTISAEKNSTIVFPLPIDMLTYFMRASEAAPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MES6</accession>
    <name>A0A8J2MES6_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein eL38</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">60S ribosomal protein L38</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HICCMSTLAB_LOCUS4596</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the eukaryotic ribosomal protein eL38 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5087741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MES6"/>
    <dbReference type="OrthoDB" id="10250488at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022618">
        <property type="term" value="P:protein-RNA complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.720.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002675">
        <property type="entry name" value="Ribosomal_eL38"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038464">
        <property type="entry name" value="Ribosomal_eL38_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10965">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10965:SF0">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01781">
        <property type="entry name" value="Ribosomal_L38e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6 8" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="139"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG5087741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="187" mass="21317" checksum="4659589E7ABA2C3A" modified="2022-05-25" version="1">MKSRTSSLKPEERTPTVKIKKNAENVKFKVRCSRFLYTLVITDKEKAEKLKQSLPPGIAAIRGLGVRGSSLTTTESSSLSKLNLLFFGHLAPVASETEAIAPAYPSISFFMNKNHYLIFVSLKLTSKTFRFFFEDRLNSFISFSFASLYPYFFSLGLILRVRHFHFPFADSCHNGFFQLNGFDLLFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MGP5</accession>
    <name>A0A8J2MGP5_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Eukaryotic translation initiation factor eIF1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Protein translation factor SUI1 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HICCMSTLAB_LOCUS3291</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Probably involved in translation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SUI1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5081463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MGP5"/>
    <dbReference type="OrthoDB" id="10248435at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11566">
        <property type="entry name" value="eIF1_SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.780.10:FF:000010">
        <property type="entry name" value="Protein translation factor SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.780.10">
        <property type="entry name" value="SUI1-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001950">
        <property type="entry name" value="SUI1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036877">
        <property type="entry name" value="SUI1_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005874">
        <property type="entry name" value="SUI1_euk"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01160">
        <property type="entry name" value="SUI1_MOF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10388">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01253">
        <property type="entry name" value="SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004499">
        <property type="entry name" value="SUI1_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55159">
        <property type="entry name" value="eIF1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50296">
        <property type="entry name" value="SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0810">Translation regulation</keyword>
    <feature type="domain" description="SUI1" evidence="8">
        <location>
            <begin position="28"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00042714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00071306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAG5081463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="110" mass="12359" checksum="B5ECD73A67334D44" modified="2022-05-25" version="1">MSIQNLNTFDPFADANKGTDDDVQDGLVHIRIQQRNGRKTLTTVQGLSSEYDLKKIVRACKKEFACNGTVVDHPEYGEVLQLQGDQRENICQWLTKAGLAKPDQLKVHGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MGW6</accession>
    <name>A0A8J2MGW6_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Similar to Cdk12: Cyclin-dependent kinase 12 (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HICCMSTLAB_LOCUS5790</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5090903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MGW6"/>
    <dbReference type="OrthoDB" id="28397at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008024">
        <property type="term" value="C:cyclin/CDK positive transcription elongation factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030332">
        <property type="term" value="F:cyclin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008353">
        <property type="term" value="F:RNA polymerase II CTD heptapeptide repeat kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032968">
        <property type="term" value="P:positive regulation of transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023340">
        <property type="entry name" value="UMA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF546">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51497">
        <property type="entry name" value="UMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="UMA" evidence="8">
        <location>
            <begin position="16"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="732"/>
            <end position="1041"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="68"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="597"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="784"/>
            <end position="870"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1211"/>
            <end position="1241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="68"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="97"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="139"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="185"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="256"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="272"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="296"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="339"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="425"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="474"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="501"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="535"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="628"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="816"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1215"/>
            <end position="1241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAG5090903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="1241" mass="139093" checksum="39ADACD6C62F4609" modified="2022-05-25" version="1">MARASISSSDPVSSYMDGVNVKIAEAYKPPRKVTLPAAYNNKFPDITRYNYDFSVERSILNKLEEWRKVRKENKEAREQRIEERKKREQEEEELTKSNSPSSPEVLPLPVKVAPAPKTTILTPQPLSPPCDLQDIDLNRHRRHGKSSRSSGKKKKKRSRDKSLDSDIPKVASSIVKPLVEYSDVSSEDLSEPEAGEIQSEESRGNSYTDSDLGVLRPRYYGSPKRPVVPQPPGDLRPSPISMSPSPPMRQRHFSPVEEPQVPSPEFTEERRYRRKEKKHRREKKKKISLSPSSSSSKKRKRKSKRASRSLSPEIVQEFVPESPKMVEKWPESPPMPLKDSTSPISPATPQQRSPSDMDLESPQHVTPPILRRSESPHTPLLPPRPSSPEKMSKHSPEPRNSPPHRVPRADSPLTRRRHSPSSPPGRREHSPRRREFSPSPMHRVRHSPSPRRREFRASMSPGSKRRKREDMMRQHRHHDRERKDKRKSRLMNRGVPDMSRSRSRSPRWRKPSRSRSRERRRSRTPKRSPPGKLPRSARKRSKSPRRIPSPHRTRLRSPTSLKAINLRSQAKINETTLFAEMVKDRNIKELAYKKYQAAKEKEVNSQDDVQIIEGSDEKDSSSCSTDKSNGRVDKSVEIVDIPVPVPETSEGLTPPLPGQTGSNSPFPPNGASVCQKTPPPPPTDIPGTGHVPGTVPGIASVPETTHVPCTVLGTVPVPSTVPAVPTPNLIPVQATVPVVTGNSVPVAVSSPMNAISKFNTPNNLVPIKSIDPPKAPFVQFKTGKLSKLPLPPGINQNDLESIDSPPSRSPSPQRKGGTGGTGGTGLIKNIKKGITELPMPPVAQGEDYSGEEDPNATPPRNKLERLAPKPKLKRPKILKKRNLRNCHAPIGEVKLADFGLARLYNAEDRQRPYTNKVITLWYRPPELLLGEERYGPAIDVWSCGCILGELFWKKPLFQANMEMMQLDLIARVCGTPTPAVWPSVIKLPLWHTLKAKKTYRRRLREDFTFLPPTALDLLDKMLELDPEKRITAADALKSAWLRNIEPERMPPPDLPTFQDCHELWSKRQRRKVREQLENANAGSGLKRLKEGYHVQNLPEGFENSFGASPSYCYSPKGPRPTKENFNSEISEDTLAKKLNSLAGALGQGKPIRVDDLMSLRVDNESDPKAVQLVTELHSEIRQAANARPTGQLEAHLPLLIPPAALMSRYGLDSCKSPQGNTNKSSQVFPPPSSSTQSAFGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MIM4</accession>
    <name>A0A8J2MIM4_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Serine proteinase stubble</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HICCMSTLAB_LOCUS3823</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5083382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MIM4"/>
    <dbReference type="OrthoDB" id="6437225at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000082">
        <property type="entry name" value="Plasma kallikrein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040479">
        <property type="entry name" value="CLIP_SPH_mas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24258:SF140">
        <property type="entry name" value="BCDNA.GH08420-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24258">
        <property type="entry name" value="SERINE PROTEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18398">
        <property type="entry name" value="CLIP_SPH_mas"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035234433" evidence="2">
        <location>
            <begin position="19"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="3">
        <location>
            <begin position="499"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="106"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="208"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="348"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="359"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG5083382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="745" mass="80866" checksum="C6AEB2A2E8D94848" modified="2022-05-25" version="1">MAVRWILLLLMWFVYASAQDDDSLAGSFLSGLLDSLADTANSADCPGVCVHALATLICDKVLDEVQCPTSSMRCCVNEPANGTDGSVSENDIEGIAITSTTFKEIPPTTTTTTTTTTPVPTTVSTTTPAPITSITTVSTTQSNGHKNASDKTVPKCSGVCIEARIANYCEAIVNIDSLCKPEHRCCVSRDSFGNNPPPEFYVIDRSKTAKNTTQTSARPEEKYAEKSTSTVTPATQYTTTARPKPAPRKPCRGECVNGLFALFCENHDHEAECPSDGTCCITDAPAKVEVKTTTTPRPTTRPPPPKLPPCRGFCLLTIMAAFCERPNTIIGRTSTCQSGYVCCDESNAPAHTPRPRPRPSTTRAPTTTVSMPPDPRPECPGSCIVSYLSFTCFRNAELTNIFKCKKFGHQCCAPKSLIREFQHGNSTDTISNKNDSFIASRPYTSTLPTPYETTMTTPMTTTTQIPSTKSPIYSKYVCGVKGTSRGPIQARGILRDGRVVGGEDADANEWCWQVALINSLNQYLCGGALIGTQWVLTAAHCVTNIVRSGDAIYVRVGDHDLTRKYGSSAAQTLRVATTYIHHNHNSQTLDNDIALLKLHGQAELKDGVCLVCLPARGVSHTAGKRCTVTGYGYMGEVRFKLYFTGQIFEKIKFLNVSICSESYEKVRRLHDIVTPRLLVINIYQNNKIFQGDGGGPLVCQDDGFYELAGLVSWGFGCGRVDVPGVYVKVSAFIGWINQIISVNNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MIR7</accession>
    <name>A0A8J2MIR7_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Similar to Aggf1: Angiogenic factor with G patch and FHA domains 1 (Mus musculus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HICCMSTLAB_LOCUS3899</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5083665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MIR7"/>
    <dbReference type="OrthoDB" id="2538319at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053027">
        <property type="entry name" value="AGGF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000467">
        <property type="entry name" value="G_patch_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041591">
        <property type="entry name" value="OCRE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23106">
        <property type="entry name" value="ANGIOGENIC FACTOR WITH G PATCH AND FHA DOMAINS 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23106:SF24">
        <property type="entry name" value="ANGIOGENIC FACTOR WITH G PATCH AND FHA DOMAINS 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01585">
        <property type="entry name" value="G-patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17780">
        <property type="entry name" value="OCRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00443">
        <property type="entry name" value="G_patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50174">
        <property type="entry name" value="G_PATCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FHA" evidence="2">
        <location>
            <begin position="235"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="G-patch" evidence="3">
        <location>
            <begin position="390"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="167"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="318"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="365"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="404"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="179"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="209"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="371"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG5083665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="462" mass="52246" checksum="17AD2198A7F245EC" modified="2022-05-25" version="1">MNSNECEEYSENEDDNKFNIKINISEDFDELLKDFPEVLEFITKLKKYIKYQDKKITKLHNKLMNQKKGRKFGKEFLDKEVQTDFGDKLSGEGVAEWSESNISEQVKQVAESTLQQSGFVYEETSGLYYDYNTGYYYDAAKGLYYDGNSGIYYYYDNETKSYKYHSQLSTAEVPDTKKKEKRKKNKKHKDVAKKSRDTPMDEVVEEGECSASETSSSTESSSESTDNDGKCCKKLPTMHADNRQGNKSSASQYELIDLGSRNGTYVNGKRVSVAKQESEPVEIAHGSIVQVASTKLLCHVHNGHETCGHCEPGLIQQPVDESGNSRKVHSHKSELKRLKNKFGVDKDNTDKASQVARGYQDRAQARREKVGSSNQYAKTQQSSVDTSIAKDNKGFKLLSKMGWSEGQSLGKDGDGRTEPVQMVNNNAKKGLGNTDLPSIEMDASVEKKQAIWRKTRQRYDQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MJ43</accession>
    <name>A0A8J2MJ43_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Similar to Samui: BAG domain-containing protein Samui (Bombyx mori)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HICCMSTLAB_LOCUS7392</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5094066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MJ43"/>
    <dbReference type="OrthoDB" id="333905at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000774">
        <property type="term" value="F:adenyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050821">
        <property type="term" value="P:protein stabilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.120">
        <property type="entry name" value="BAG domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039773">
        <property type="entry name" value="BAG_chaperone_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036533">
        <property type="entry name" value="BAG_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003103">
        <property type="entry name" value="BAG_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12329">
        <property type="entry name" value="BCL2-ASSOCIATED ATHANOGENE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12329:SF5">
        <property type="entry name" value="STARVIN, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02179">
        <property type="entry name" value="BAG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00264">
        <property type="entry name" value="BAG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63491">
        <property type="entry name" value="BAG domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51035">
        <property type="entry name" value="BAG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BAG" evidence="3">
        <location>
            <begin position="393"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="49"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="149"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="197"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="276"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="478"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="88"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="169"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="197"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="281"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="340"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="359"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="374"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="526"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="582"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="604"/>
            <end position="613"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG5094066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="635" mass="71845" checksum="A7FE29FED3474474" modified="2022-05-25" version="1">MDSPVIVDTASKFGRDLDPGFPFDDDSFSRRGDIRSHLDDLAARHPEFAEHLLGPPWGDIPFHGTLRNRRRGSGSHSQQGHPDEDARSQASGSSAASAASGASGVSSHGEPDLIYQHQELTGNNKIPQYGLRNTVDIGQHRHNMENLEKADRGQRSMSAPPENRPDQFQQPNQNNSKQNYYQNQNPRFVSRVDITPQYTNQNQNPNAVPNPQQQSPQNQSPPQQQQQQQHQHHQPQGNVRHIPIFVEGRDEPVISKGKAPPYVRQQSPSRFYQPAFDSSHPEFNSSNYQRPSSQFNQHFGGRNRDWPSQFQEHFQDPFPDTFDHPTIRKTTHHNQSHSPFKHEDRRRDQSPVHMKHHQQANQQHQQPQQEQEQEQPKRQESPKPRKQVVPTDPLEKVALVQNEIDSLTEQVKQWSGTSRKDKQYIYLDEMLTRELIKLDDIETEGKENVRQARKNAIKSIQDSISLLESKAPLPITEINQQVEQKNPPEAAESVEPMESETPVKEEQGEAIPLPSPTKIEPVVGDSEPKDTDKSEAADALITVEIAPGVPMETAPEEKKSGDDSVMELEVQPVETQTTQDATELKKENEASTKKEANETIPAKSPKKLKKAKKQTPVSIEPIPLPASEEQSRLAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MJP9</accession>
    <name>A0A8J2MJP9_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Eukaryotic translation initiation factor 3 subunit J</fullName>
            <shortName evidence="4">eIF3j</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HICCMSTLAB_LOCUS7938</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the eIF-3 subunit J family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5095898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MJP9"/>
    <dbReference type="OrthoDB" id="20381at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005852">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.60">
        <property type="entry name" value="Eukaryotic translation initiation factor 3 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03009">
        <property type="entry name" value="eIF3j"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023194">
        <property type="entry name" value="eIF3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013906">
        <property type="entry name" value="eIF3j"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21681">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21681:SF0">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08597">
        <property type="entry name" value="eIF3_subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4 6" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3 4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="10"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="25"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="45"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="64"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAG5095898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="234" mass="27180" checksum="B295F6CDA97C65C8" modified="2022-05-25" version="1">MEDSWDADNIDAKLEMTLRSNKWEGEDEEEEVKDSWEDADEEEEKKDVEKPAEAPKPKAKPKKKVAEKIEERERKAREEAEKKAKEKEEAMTPEERRAEQLRRQKMAEEADLRLAMETFGVSPNEVLIPDTKEEFEQYAESMLQQINLYKSHAEYPTFAEDLISRIAVNLPSISLKKLGTSINNLAIEKQKLEKGDKGKKNKGKGKAKLKLEGDNTHLNEYDSYTYDDNYDDFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MKB9</accession>
    <name>A0A8J2MKB9_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Similar to Arpp21: cAMP-regulated phosphoprotein 21 (Mus musculus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HICCMSTLAB_LOCUS5942</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5092138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="278430at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02642">
        <property type="entry name" value="R3H_encore_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.50">
        <property type="entry name" value="R3H-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001374">
        <property type="entry name" value="R3H_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036867">
        <property type="entry name" value="R3H_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051937">
        <property type="entry name" value="R3H_domain_containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024771">
        <property type="entry name" value="SUZ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15672">
        <property type="entry name" value="CAMP-REGULATED PHOSPHOPROTEIN 21 RELATED R3H DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15672:SF8">
        <property type="entry name" value="PROTEIN ENCORE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01424">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12752">
        <property type="entry name" value="SUZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00393">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82708">
        <property type="entry name" value="R3H domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51061">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51673">
        <property type="entry name" value="SUZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="R3H" evidence="3">
        <location>
            <begin position="398"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="domain" description="SUZ" evidence="4">
        <location>
            <begin position="462"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="33"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="89"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="135"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="338"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="610"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="706"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="880"/>
            <end position="903"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="940"/>
            <end position="1018"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1169"/>
            <end position="1199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1251"/>
            <end position="1331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="167"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="197"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="248"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="259"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="286"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="351"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="628"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="639"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="668"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="711"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="740"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="779"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="840"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="886"/>
            <end position="897"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="952"/>
            <end position="967"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="979"/>
            <end position="995"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1008"/>
            <end position="1018"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1171"/>
            <end position="1186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1269"/>
            <end position="1284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1295"/>
            <end position="1313"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAG5092138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="1331" mass="145472" checksum="7D9B3CAD3179E916" modified="2022-05-25" version="1" fragment="single">KNILKSENVKCFNSFVSIAIDLLVPSIVVHKGNSSQSRPVSPIGASSAGMPALPTGKNVLVSGGTAYSTLGDQEMIDSDVNVTIENLSSGNTVTRPTSLPVPSCQPSPPDKIDSESNNYRNRANTKVKLLVRSHAMRESTSPPREPHNGAASPRSPQQSDAIEKKLGNASNGGLSPNNSNSKLNNESIYNNSNNLSAAQSPKQTRNTATSPTCRTPSRNGQSSPLQTPKSASTSPTNNRDNKNDNGQRSKATSPLVVTSSSKCNNCVKNNHNNDKPGLLQTPPSPSKSTGVQYSPKNHGHTNNYSNNNCQQSRNDNRRSLSVCNNQCSNQCSSNTLTVGSRTRHKLRHQNSSSQGSGSLDSVSPCLSRDNSTELYTDSTGIDLEQFIAVTINRNQKDRSVLLKIERELIEFAKDHHKVCHKFPNMSSYNRMLVHRVAAYFGMEHNVDQSGLSVIVTRTKNMRIPDTRFKEHIRDDLILTEEPRRSILKRDSSSFEDGYNFKSPDRLSGDYCRRSKSFEEREEEYEKVRRRIFKDSSGESNEVVSWPYWSSSESSDASARYRLLHPGDHSGRHARLSKGESCDGREAFRGVLRPSVSKSFSFGGYTRGMLSRGDSVTSTRSAGARLTKQDSGASMCSRLSPSSSGYKSQSQRSDTTISPSPSPSPIPANSCSHVQSSQNNNNASIDTQSNETVIWAVTNISSVPLGSVIMNPRTNQPYTNSDGTLYRFDPDNPPKVFSDIEEIRESPSSETPDKFPELPESPRHNVPVNKYSSKKHKNSIKSSPPSSVSNNNAVSNRVTSTATSPTLPYSASPPPAVPQPIQVQDLPYNQPIKSPPPCTPGSLNPQYQNYSQNTELNYNPPVFTNAQPQNIIQRPPDLAINQQQQQQPPPPPPPPPPDMVFGQNNVYGNYPMMMQTAVHPQSEVTDLSGYFMGMNVYEQSRAGSEASQTTPTFPAPPPPPPPPLPPPNGHNAPNNQAYWQPPNQGQHPQQHSHPPNQIAPQQMYFVPPSGSTLTSNDRSTIQHQRFPSNYTYNPQTMTPPNTGPNYPVNGYPISYNSMPAVTPSPTDYSYQNPLSMMPTYYSGQPGMQPPMMWRVPTPPTTPTSNQMPGIPVMYVNSGTYPPPTMVTAGSYGHQLSGTAPAPPGAVYMTPSLLPNLPNLVFRQNVPMMTSGIRASTPSGSQRTSRSPTPGHEYPINSPNGPTVNGVAGIDNRNAQAQSRYPLPMYQGLHIVPGDIRLMHPGMANNPRLQYAPGPSPSVVQGCPRPFRPPSYSSNSGCPTPNSFDGRNQKIRKQRSKVTTLPSNVRSNVYQVSSMPPNPPKDMQGTVKVTINR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MKK5</accession>
    <name>A0A8J2MKK5_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Cc_35a_2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS5443</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5089966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MKK5"/>
    <dbReference type="OrthoDB" id="7681487at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5089966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="290" mass="34298" checksum="D012F370493FC561" modified="2022-05-25" version="1">MSQLNNRNSYPTIPTLLGNRVDSLEHSTSHCAGLSLNMIHFSDKRIKSKMIELNNFIITLCRYIDKVCNVLKNECNKYIRNIQLENISIEFYKEYKTVLTIYEKLVKDLKSFLSDIQKDFNKQVLKWLEDLDSSKQRYIDITKESDGLERNRHMYQDNDFEFDSDRAKSRQLYWKKYLNLKSQKDKTAQLYNKRFADLNQFIVKISILISHITEGRIFYTPIFNSHKNYTISLKDFVDEFGKLVNMTDAAMKKKGEVIAKLINESMKNLDKMTETFDVNAIMELKQIRLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MLE5</accession>
    <name>A0A8J2MLE5_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Similar to WBP4: WW domain-binding protein 4 (Gallus gallus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HICCMSTLAB_LOCUS7031</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5093705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MLE5"/>
    <dbReference type="OrthoDB" id="191651at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:monoatomic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.20">
        <property type="entry name" value="SLC41 divalent cation transporters, integral membrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000690">
        <property type="entry name" value="Matrin/U1-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003604">
        <property type="entry name" value="Matrin/U1-like-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036739">
        <property type="entry name" value="SLC41_membr_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013085">
        <property type="entry name" value="U1-CZ_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040023">
        <property type="entry name" value="WBP4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13173">
        <property type="entry name" value="WW DOMAIN BINDING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13173:SF10">
        <property type="entry name" value="WW DOMAIN-BINDING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06220">
        <property type="entry name" value="zf-U1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00451">
        <property type="entry name" value="ZnF_U1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161093">
        <property type="entry name" value="MgtE membrane domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50171">
        <property type="entry name" value="ZF_MATRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Matrin-type" evidence="6">
        <location>
            <begin position="11"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAG5093705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="240" mass="27627" checksum="69D530A59D563B2C" modified="2022-05-25" version="1">MADYWQSQDRKFCDFCKCWIADNRASIDFHKNGKKHKESASKRVKMIYKNSTKQTKIQKKIECDLENMEKAALAAYIKDLEGNTVDITAQEIMKNKRNRIDEPIVVSPNQVPEVLSVRNSRLESSKNLPVDVVFCDPTTFYRAYRRDYSVPDRVDPYGPWTSVEIKSPKIVDLQLPAKRVIQVVTPVVKETRHWPVYQVVSEVYILVPALLGLKGNLEMTLASRLSTHANLGHMDTEKQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MM45</accession>
    <name>A0A8J2MM45_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS8587</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5097197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MM45"/>
    <dbReference type="OrthoDB" id="6623312at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035248902" evidence="1">
        <location>
            <begin position="20"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5097197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="240" mass="27200" checksum="BE25591704C2D9EC" modified="2022-05-25" version="1" fragment="single">MNKLTLSICVLFLGLQAAGQKWPRSIDNQRYERRPNNIYSEIQSEYVGQEFRADKAAQEEEIALVKMLSEAGPIDFEKWDSIGERVISRANVTEETKRVVRQVKKQRPGFFWTLFSVIFETINDTRSTIQQVGDVLAENIVSDTTTEAPKISPQGKHTAVTASADVTISATNQTSTTEAPFKLTRSTLENIVRRNVRGLVRLFNIEWKDAVTQSRANIKKFRKELSKSAQPFLADNPDAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MMA8</accession>
    <name>A0A8J2MMA8_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Cytosolic Fe-S cluster assembly factor NUBP1 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HICCMSTLAB_LOCUS8710</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. The NUBP1-NUBP2 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins. Implicated in the regulation of centrosome duplication. Negatively regulates cilium formation and structure.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="11">Binds 4 [4Fe-4S] clusters per heterotetramer. Contains two stable clusters in the N-termini of NUBP1 and two labile, bridging clusters between subunits of the NUBP1-NUBP2 heterotetramer.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Heterotetramer of 2 NUBP1 and 2 NUBP2 chains.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 11">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the Mrp/NBP35 ATP-binding proteins family. NUBP1/NBP35 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5097443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MMA8"/>
    <dbReference type="OrthoDB" id="1741334at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140663">
        <property type="term" value="F:ATP-dependent FeS chaperone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02037">
        <property type="entry name" value="Mrp_NBP35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000427">
        <property type="entry name" value="Cytosolic Fe-S cluster assembly factor NUBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02040">
        <property type="entry name" value="Mrp_NBP35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03038">
        <property type="entry name" value="NUBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000808">
        <property type="entry name" value="Mrp-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019591">
        <property type="entry name" value="Mrp/NBP35_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028601">
        <property type="entry name" value="NUBP1/Nbp35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033756">
        <property type="entry name" value="YlxH/NBP35"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23264:SF35">
        <property type="entry name" value="CYTOSOLIC FE-S CLUSTER ASSEMBLY FACTOR NUBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23264">
        <property type="entry name" value="NUCLEOTIDE-BINDING PROTEIN NBP35 YEAST -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10609">
        <property type="entry name" value="ParA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01215">
        <property type="entry name" value="MRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 11" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="7 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 11" id="KW-0408">Iron</keyword>
    <keyword evidence="9 11" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="11">
        <location>
            <position position="12"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="26"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="29"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="35"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="66"/>
            <end position="73"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="240"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>ligand shared with heterodimeric partner</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="243"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>ligand shared with heterodimeric partner</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00054528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAG5097443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="323" mass="34530" checksum="F45BF97146752512" modified="2022-05-25" version="1">MADVPTNAPEHCPGTESNDAGKVSACAGCPNQNICASGATKQPDPGIELVKKRLADVKNKILILSGKGGVGKSTMTCLIARALAADSADRNVGVLDIDICGPSQPRVLGVVGEQIHQSGSGWSPVYVEDNLSLMSIAFLLNSPSDAVIWRGPKKNGMIRQFLSEVDWGNLDYLILDTPPGTSDEHLSATTYLKNSGITGAIIVTTPQEVALLDVRKEIDFCKKVKIPILGTIENMSIFVCPKCKNSAEIFPALTGGARNMSEEMNVEFLGSIPLDPLLARCCDEGKNVFTEMPESPTIVALKKIVTRIIDKCENSEMKTAEAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MMN0</accession>
    <name>A0A8J2MMN0_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="19">Similar to brm: ATP-dependent helicase brm (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">HICCMSTLAB_LOCUS7578</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5095175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6017at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048513">
        <property type="term" value="P:animal organ development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048731">
        <property type="term" value="P:system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd17996">
        <property type="entry name" value="DEXHc_SMARCA2_SMARCA4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10810:FF:000008">
        <property type="entry name" value="Chromatin structure-remodeling complex subunit snf21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.170:FF:000008">
        <property type="entry name" value="probable global transcription activator SNF2L2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:003020">
        <property type="entry name" value="SNF2-related domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.5.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006576">
        <property type="entry name" value="BRK_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037259">
        <property type="entry name" value="BRK_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018359">
        <property type="entry name" value="Bromodomain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014978">
        <property type="entry name" value="Gln-Leu-Gln_QLQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014012">
        <property type="entry name" value="HSA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029295">
        <property type="entry name" value="SnAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10799">
        <property type="entry name" value="SNF2/RAD54 HELICASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07533">
        <property type="entry name" value="BRK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07529">
        <property type="entry name" value="HSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08880">
        <property type="entry name" value="QLQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14619">
        <property type="entry name" value="SnAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00503">
        <property type="entry name" value="BROMODOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00592">
        <property type="entry name" value="BRK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00297">
        <property type="entry name" value="BROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00573">
        <property type="entry name" value="HSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00951">
        <property type="entry name" value="QLQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01314">
        <property type="entry name" value="SnAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160481">
        <property type="entry name" value="BRK domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00633">
        <property type="entry name" value="BROMODOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51204">
        <property type="entry name" value="HSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51666">
        <property type="entry name" value="QLQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0010">Activator</keyword>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 12" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="6" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="4 19" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="QLQ" evidence="18">
        <location>
            <begin position="432"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="domain" description="HSA" evidence="17">
        <location>
            <begin position="629"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="15">
        <location>
            <begin position="915"/>
            <end position="1080"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="16">
        <location>
            <begin position="1234"/>
            <end position="1395"/>
        </location>
    </feature>
    <feature type="domain" description="Bromo" evidence="14">
        <location>
            <begin position="1585"/>
            <end position="1655"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="472"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="615"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="742"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="815"/>
            <end position="870"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1518"/>
            <end position="1564"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1675"/>
            <end position="1736"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="13">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="13">
        <location>
            <begin position="52"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="13">
        <location>
            <begin position="83"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="13">
        <location>
            <begin position="106"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="119"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="13">
        <location>
            <begin position="152"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="219"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="250"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="13">
        <location>
            <begin position="343"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="500"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="615"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="742"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="815"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="838"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="1527"/>
            <end position="1536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="1552"/>
            <end position="1561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="1676"/>
            <end position="1688"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="CAG5095175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="1736" mass="191280" checksum="9884938E13288CD5" modified="2022-05-25" version="1">MASPSPSSSPMPPPQAPSPMGPPQAPSPSNPQGSPMGPPQHHPHSPTQVYPGGPPPPSGPGPGPGGPPMSQPPQPPSQQQNYPPHPQQMPPNMGPQGPPGAPPGAQGPGGPMMPGQMGGPPSAGHMGPNQMGPGGPPPLVSGQMFPGPPNMGPGGPNQMGPGGPNQMGPGHIGPGGPPAPHMQGPNNQIPSGPGHMQGPPPSGHINMGPGPGPIPPGPGHMNPSMPGGPSMGPGGPPNMCPPNQGHGANGHSQMNMTGPGSQMNIGPGGPGVPMIMGGPNASGLGPAGPMGPNSGPGNQMGPGGPMMPGSGPNQMPPGGPASQMGPGGPLPMSANNSGGPGGPGGPPGPPVMGPMPPGAQNQPLGPMGPGGPGNSMPPVPGGPPGGSGTGQENLSALQKAIDSMEEKGLQEDPRYSQLLALRARGQGGANDRFTTQQFQQLRVQIMAYRLLARNQPLSQQLALAVQGAAPLPGLNRPNDSTPAGPLQVPSVNGPPRPGSQPSQQLQQHQQQQQVGNKSNRVTSVVKPAGLDPLVILQERENRVATRIALRMEQLSNLPTNMPEDLRIQAQIELRMLRVLNFQRQLRSEIIACTRKDTTLETAVNVKAYKRTKRQGLREARATEKLEKQQKLEAERKRRQKHQEFLTSVLQHGKDWKEFHRNNVAKMSRLNKAVLNYHANAEREQKKEQERIEKERMRRLMAEDEEGYRKLIDQKKDKRLAFLLSQTDEYICNLTEMVKQHKMEQKRKQVEEQKRKKKKKKLQDGTSVNEDGTPAEDTRVHVYEVSTGRTLTGEDAPMMSQLNAFMESHPGWEVIESDSEEDDDDDEEENVSEQKAKTGDFSAASAADSNSGAGDSVSETRKKLNKAKVEDDEYKTEEQTYYSIAHTVHETVTEQASIMVNGALKEYQIKGLEWLVSLFNNNLNGILADEMGLGKTIQTIALVTHLMEKKKVNGPFLIIVPLSTLSNWVLEFEKWAPSVVVVSYKGSPAGRRAIQSQMRATKFNVLLTTYEYVIKDKSVLAKLQWKYMIIDEGHRMKNHHCKLTQVLNTHYLAPHRLLLTGTPLQNKLPELWALLNFLLPSIFKSCSTFEQWFNAPFATTGEKVELNEEETILIIRRLHKVLRPFLLRRLKKEVESQLPDKVEYIIKCDMSGLQKVLYRHMQSKGVLLTDGSEKGKQGKGGAKALMNTIVQLRKLCNHPFMFQAIEEKYCEHIGVQGSHTVSGPDLYRASGKFELLDRILPKLKATNHRVLLFCQMTQLMTIMEDYLSWRGFKYLRLDGTTKAEDRGDLLKRFNDPGSQYFLFLLSTRAGGLGLNLQAADTVVIFDSDWNPHQDLQAQDRAHRIGQKNEVRVLRLMTVNSVEERILAAARYKLNMDEKVIQAGMFDQKSTGSERQQFLQSILHQDDADDEEENEVPDDETVNQMIARSEGEFEAFQKLDLERRREDAKSGPNRKSRLLEENELPDWLVKDDDEVERWTYEEDEERFLGRGSRQRKEVDYTDSLTEKEWLKAIDDDGVEFDDEEEDDKKKKKTRKRRKRGEEDEEPVQKKRRGAGSSSGAGPSVDMKLRKSMKKLLMVVVNYTDSTDGRLLSEPFMRLPSRRELPDYYDVIKKPLTINKLLKKVDEGKYSSVDELEKDFIQLCKNAQIYNEEASPIHEDSIVLESVFINARQRLEAEGSVSDDGNNSSPGDCDDGSDGDSSVRMKIKLKGRKSESRTGRRKRITKKYVSDDDDDADDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MMN7</accession>
    <name>A0A8J2MMN7_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Similar to Ak8: Adenylate kinase 8 (Rattus norvegicus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HICCMSTLAB_LOCUS7594</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5095207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MMN7"/>
    <dbReference type="OrthoDB" id="522106at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019205">
        <property type="term" value="F:nucleobase-containing compound kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22979">
        <property type="entry name" value="DD_AK8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.890.10">
        <property type="entry name" value="cAMP-dependent protein kinase regulatory subunit, dimerization-anchoring domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000850">
        <property type="entry name" value="Adenylat/UMP-CMP_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23359">
        <property type="entry name" value="NUCLEOTIDE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00406">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47391">
        <property type="entry name" value="Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="336"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAG5095207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="411" mass="47371" checksum="694B349B42369714" modified="2022-05-25" version="1">MNMTKKYIGLNCFLPYLEKHRIYELFNDINTDLVIQKPSDPLHFIKHWLEENPVYQDRLRIILILSSPDFGKFVNLPRNNSEARALKRNGILPTHVFEIIDSLGDNSRDNALKAQVSKNNGSVDYNLHINSLRDEYKPFLHKIESTGRTCEEIGNICISITRRQRYDIPSIYRVVLIGPRGSGFKTVAKYLSQKYGLVNVDLDYLLEQTKKQNSLLGQELRSLDYRGTVPGSEMRFKVVENKLMSQECNRKGWVLTRYPLTVEDFRLLNSLTTPPNRIIFLSVDQVTCRERLLSRRFNILTGSEHHLTIDSDFQCDFGQELAAHPKDYGTKVEQDVSYFFLLFNLIIIIIVIIIEWLKCINLKLFQENIESILKHAGDSVNVVDATSGIKSVCERVEACLTRPICNAPARK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MMP6</accession>
    <name>A0A8J2MMP6_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS6864</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5093474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MMP6"/>
    <dbReference type="OrthoDB" id="206969at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018800">
        <property type="entry name" value="PRCC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13621">
        <property type="entry name" value="PROLINE-RICH PROTEIN PRCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13621:SF2">
        <property type="entry name" value="PROLINE-RICH PROTEIN PRCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10253">
        <property type="entry name" value="PRCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="389"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="68"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5093474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="411" mass="45341" checksum="5E8044C071DF03F8" modified="2022-05-25" version="1">MSLAGLVAYDSSDESDNEDCPKENTTKNVEITISSDNLKNSKSIQNDIKSKLPEPRQKIQENDRLDSSNDVGNSSSSLFFNILPKPKNEIINEEIDEELDDIPVMSMKNITIEKPIKKIREPVKISIPSLSDYDDVEEPTKVIRKPQPSKGLPGVLANIPPPKSELISTKNMVPHVLTKKSGSVTSLALKPTQVKKNAQNHTQVNKQVEETKTSKALDAITYASDSSDEEDTKVSSKSGIDFFSLSEPVNLPISEQALASHLLPMPEKMEISNCVGETTNNVEEPEVNGQNQKTLTSTVMNLPRDEILMKNKAAIGPKLPVPEQEFRLDSEGNVAFDDKAIEYLCGKRGVKRKHQIVNETEIIDINGEDIKPDERDWLIKALTEEPVQRPVSLGSGPSARACKMSGGKSPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MMQ4</accession>
    <name>A0A8J2MMQ4_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">xanthine dehydrogenase</fullName>
            <ecNumber evidence="5">1.17.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">HICCMSTLAB_LOCUS4114</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>hypoxanthine + NAD(+) + H2O = xanthine + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24670"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17368"/>
            <dbReference type="ChEBI" id="CHEBI:17712"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.17.1.4"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>xanthine + NAD(+) + H2O = urate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17712"/>
            <dbReference type="ChEBI" id="CHEBI:17775"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.17.1.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 20">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="21">
            <name>Mo-molybdopterin</name>
            <dbReference type="ChEBI" id="CHEBI:71302"/>
        </cofactor>
        <text evidence="21">Binds 1 Mo-molybdopterin (Mo-MPT) cofactor per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="16">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="21">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49601"/>
        </cofactor>
        <text evidence="21">Binds 2 [2Fe-2S] clusters.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the xanthine dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="24">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.17.1.4" evidence="5"/>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5084477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="8300278at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030151">
        <property type="term" value="F:molybdenum ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043546">
        <property type="term" value="F:molybdopterin cofactor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004854">
        <property type="term" value="F:xanthine dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.30:FF:000015">
        <property type="entry name" value="Aldehyde oxidase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.365.10:FF:000003">
        <property type="entry name" value="Aldehyde oxidase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1170.50:FF:000001">
        <property type="entry name" value="Aldehyde oxidase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.365.10:FF:000001">
        <property type="entry name" value="Xanthine dehydrogenase oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.365.10:FF:000004">
        <property type="entry name" value="Xanthine dehydrogenase oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.390.50:FF:000001">
        <property type="entry name" value="Xanthine dehydrogenase oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.43.10:FF:000001">
        <property type="entry name" value="Xanthine dehydrogenase/oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.465.10:FF:000004">
        <property type="entry name" value="Xanthine dehydrogenase/oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.120">
        <property type="entry name" value="[2Fe-2S]-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1170.50">
        <property type="entry name" value="Aldehyde oxidase/xanthine dehydrogenase, a/b hammerhead"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.365.10">
        <property type="entry name" value="Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.50">
        <property type="entry name" value="CO dehydrogenase flavoprotein, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="entry name" value="Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002888">
        <property type="entry name" value="2Fe-2S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036884">
        <property type="entry name" value="2Fe-2S-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006058">
        <property type="entry name" value="2Fe2S_fd_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000674">
        <property type="entry name" value="Ald_Oxase/Xan_DH_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036856">
        <property type="entry name" value="Ald_Oxase/Xan_DH_a/b_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016208">
        <property type="entry name" value="Ald_Oxase/xanthine_DH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008274">
        <property type="entry name" value="AldOxase/xan_DH_MoCoBD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046867">
        <property type="entry name" value="AldOxase/xan_DH_MoCoBD2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037165">
        <property type="entry name" value="AldOxase/xan_DH_Mopterin-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005107">
        <property type="entry name" value="CO_DH_flav_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036683">
        <property type="entry name" value="CO_DH_flav_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002346">
        <property type="entry name" value="Mopterin_DH_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022407">
        <property type="entry name" value="OxRdtase_Mopterin_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014309">
        <property type="entry name" value="Xanthine_DH_Mopterin-bd_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014307">
        <property type="entry name" value="Xanthine_DH_ssu"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02963">
        <property type="entry name" value="xanthine_xdhA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02965">
        <property type="entry name" value="xanthine_xdhB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45444">
        <property type="entry name" value="XANTHINE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45444:SF3">
        <property type="entry name" value="XANTHINE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01315">
        <property type="entry name" value="Ald_Xan_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03450">
        <property type="entry name" value="CO_deh_flav_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00941">
        <property type="entry name" value="FAD_binding_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00111">
        <property type="entry name" value="Fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01799">
        <property type="entry name" value="Fer2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02738">
        <property type="entry name" value="MoCoBD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20256">
        <property type="entry name" value="MoCoBD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000127">
        <property type="entry name" value="Xanthine_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01008">
        <property type="entry name" value="Ald_Xan_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01092">
        <property type="entry name" value="CO_deh_flav_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="2Fe-2S ferredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55447">
        <property type="entry name" value="CO dehydrogenase flavoprotein C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47741">
        <property type="entry name" value="CO dehydrogenase ISP C-domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54665">
        <property type="entry name" value="CO dehydrogenase molybdoprotein N-domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56003">
        <property type="entry name" value="Molybdenum cofactor-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00197">
        <property type="entry name" value="2FE2S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00559">
        <property type="entry name" value="MOLYBDOPTERIN_EUK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 21" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="10 20" id="KW-0274">FAD</keyword>
    <keyword evidence="7" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="12 21" id="KW-0408">Iron</keyword>
    <keyword evidence="13 21" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="9 21" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 21" id="KW-0500">Molybdenum</keyword>
    <keyword evidence="14" id="KW-0520">NAD</keyword>
    <keyword evidence="11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="22">
        <location>
            <begin position="33"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="23">
        <location>
            <begin position="269"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="19">
        <location>
            <position position="1305"/>
        </location>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="72"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="77"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="80"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="142"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="145"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="177"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="179"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <begin position="297"/>
            <end position="304"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="377"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="400"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="444"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="462"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="811"/>
        </location>
        <ligand>
            <name>Mo-molybdopterin</name>
            <dbReference type="ChEBI" id="CHEBI:71302"/>
        </ligand>
        <ligandPart>
            <name>Mo</name>
            <dbReference type="ChEBI" id="CHEBI:28685"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="842"/>
        </location>
        <ligand>
            <name>Mo-molybdopterin</name>
            <dbReference type="ChEBI" id="CHEBI:71302"/>
        </ligand>
        <ligandPart>
            <name>Mo</name>
            <dbReference type="ChEBI" id="CHEBI:28685"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="846"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="924"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="956"/>
        </location>
        <ligand>
            <name>Mo-molybdopterin</name>
            <dbReference type="ChEBI" id="CHEBI:71302"/>
        </ligand>
        <ligandPart>
            <name>Mo</name>
            <dbReference type="ChEBI" id="CHEBI:28685"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="958"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="1054"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="1123"/>
        </location>
        <ligand>
            <name>Mo-molybdopterin</name>
            <dbReference type="ChEBI" id="CHEBI:71302"/>
        </ligand>
        <ligandPart>
            <name>Mo</name>
            <dbReference type="ChEBI" id="CHEBI:28685"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00034078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00049017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00049517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRSR" id="PIRSR000127-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PIRSR" id="PIRSR000127-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="PIRSR" id="PIRSR000127-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="CAG5084477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="1371" mass="152483" checksum="E48480A6DFA0863D" modified="2022-05-25" version="1">MGKPENDKNKESSAVDSSSFDHDLEVTKNKMSSTLIFYVNGKEIKDSDVNPEWTLLHYLRNKLKLSGTKLGCAEGGCGACTVMVSRIDRKKRKIVHLAVNACLAPVCSMHGMAVTTVEGIGSTRTKLHPVQERIAKAHGSQCGFCTPGIVMSMYALLRTVPKPSMHDLEVAFQGNLCRCTGYRPIIEGFRTFTEEWEQSQLNNKINKTENSCGQVCAMGEACCKKAFTSEVSPETFSASEFKPYNETQEVIFPPKLKLCDDLDKEYLVIKGKEVTWYRPTKLKELLLLKQKYPNAKIIVGNTEVGVEVKFKHCTYPILIQSTQIKELREITVTVNSLKVGSSVTLMELEEAMKDHISIHPEYKTRIFSEAIKMLHWFAGKQIRNVAALGGNIMTGSPISDMVPVLMAAGTKLNVCSLDGFRQVLLDHTFFTGYRRNVIKPEEVLVSMEIPFTEKSQYFIAYKQAKRRDDDIAIVNMALNVIFKPNSNEILEIHLAYGGMAPTTKLAVKTTKNMIGKKWNTELLESTYQSIVDEFPLPDDVPGGMVNYRRSLTLSLFFKGFIHILKQLQIDLPHINQIPLPKKLQSASDTFDYKPPKSSQYFQVVPKDQSDKDLIGRPIVHASAFKQVTGEAVYCDDIPHIDGELYLSLVMATKAHAKIVHVDASKALAIDGVVAFFNAKDIPEHNRWVGPVYHDEEVFVSEKVTSQGQSIGAIVAVDQITAQKAARAVIIEYEELEPILVSIEDAIEAKSFLPTTPKSIKQGDANRAFSESDHILEGEVKMGGQEHFYLETHATFAVPKDTDELEVYCSTQHPSEVQKLISHVLGISMSHINVRVKRLGGGFGGKESRGMLVALPVALAAYNLRKPVRCMLDRDEDMMISGQRHPFMFQYKVGFTKEGLIKVVEINIYNNGGYSADLSVSVLERSMFHCENAYKFPVTHVTGYACRTNLPSNTAFRGFGGPQGMFVAENIIWDVANYLGIEPEKVSEINLYKENDVTHYNQPLIRCPLQKCWQQCIDSSNYHERYAAVEKFNQENRYRKRGISVVPTKFGIAFTALFLNQAGALVHIYNDGSVLISHGGTEMGQGLHTKMIQVASRLLKIDPNKIHISETATDKVPNTSATAASAGSDLNGMAIIDACNKIISRIKHIMDANPSDTWEKWISKAYFERISLSATGFYRTPDIGFSFDTMSGIPFNYFTYGVACSEVEIDCLTGDHQVLRTDIVMDLGDSLNPAIDIGQVEGGFIQGLGLFTLEELIYSPTGTLYSRGPGAYKIPGFTDIPQEFNVSLLRDAPNPRAVFSSKAVGEPPLFLASSVFFAIKNAIQSARKETKNSSLFRLDSPATAARIRVACADDLTEKFPTADITKAWNKIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MN60</accession>
    <name>A0A8J2MN60_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Similar to uri: Unconventional prefoldin RPB5 interactor-like protein (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HICCMSTLAB_LOCUS9437</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RNA polymerase II subunit 5-mediating protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5100205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MN60"/>
    <dbReference type="OrthoDB" id="21413at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019212">
        <property type="term" value="F:phosphatase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23159">
        <property type="entry name" value="Prefoldin_URI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009053">
        <property type="entry name" value="Prefoldin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004127">
        <property type="entry name" value="Prefoldin_subunit_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052255">
        <property type="entry name" value="RNA_pol_II_subunit5-mediator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15111">
        <property type="entry name" value="RNA POLYMERASE II SUBUNIT 5-MEDIATING PROTEIN NNX3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15111:SF0">
        <property type="entry name" value="UNCONVENTIONAL PREFOLDIN RPB5 INTERACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02996">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46579">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="205"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="464"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="95"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="208"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="256"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="288"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="464"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="492"/>
            <end position="501"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAG5100205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="501" mass="58446" checksum="3A1B8598F7037971" modified="2022-05-25" version="1">MENVLSEFNPQQLFTQVLSERLKANNQQIKTWSDYKKRHEKVIEGLDVLPQDLSINCMVPIGKRALMPGKLNHTNEITVCLGDGYLAKYTAAQAKALCNRRIKKADEMLENLDKERSLYETRSMLPNCFDIFNNEDKKDFNEHWDDKKLDDWRREHREREKEYRQKLRELKKDKKESEIKTEDDLFKRLDALELQEELEDELLRLEAENEDNDGEDDEYYDESEVDSESYSSDYSEEATNEIQEKKSSKANYRLQVLNNVNTGQLTTNTEYEEKEENCNDQSAAEKQVTNKEEKSSTSKDNLLESRTVDCKKDKDEVRVKEKKVAFAEPQVKYFSNEEEMEVGTDKRRISVIEQKLYEYSKEDDDSEDESDEDDTIRIYFKHSEGAPSILVSEGDQIVTPRDIYKTIPGPKSILKKTPDFNKSDGDNVSIIDKQSHLTSLADESEEEVEHGFVYDNVVKGIKEHVPEKKVQPEELTDKPAEQPRQARPVSKFKLERAGLRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MNR6</accession>
    <name>A0A8J2MNR6_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS9059</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5099429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MNR6"/>
    <dbReference type="OrthoDB" id="7682835at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5099429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="158" mass="18075" checksum="F469E904A6F5D0C2" modified="2022-05-25" version="1">MFRGVERPVSYNRRAREWINKMLFLWAREPTPSPKGSVWLTWLTTAAFFWTCRRPIFRAIRGVVSPLRIIGSHAPSRVRSINRGKRREIAGVVPDRQSLILHPKLPVVSVTGIRTKVKRLGTGDGPHLTPCANVNKISHKIQYRVTRSGRVYGTYVPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MP11</accession>
    <name>A0A8J2MP11_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Similar to Cep164: Centrosomal protein of 164 kDa (Mus musculus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HICCMSTLAB_LOCUS8999</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5098032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MP11"/>
    <dbReference type="OrthoDB" id="6344460at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1470.10">
        <property type="entry name" value="Photosystem I PsaD, reaction center subunit II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053233">
        <property type="entry name" value="ABRA-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21715">
        <property type="entry name" value="RH04127P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21715:SF0">
        <property type="entry name" value="RH04127P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01159">
        <property type="entry name" value="WW_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WW" evidence="3">
        <location>
            <begin position="55"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="120"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="248"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="349"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="429"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="753"/>
            <end position="880"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="692"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="130"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="152"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="249"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="286"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="310"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="364"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="436"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="772"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="795"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="817"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="831"/>
            <end position="842"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="845"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="858"/>
            <end position="868"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG5098032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="1188" mass="137337" checksum="031CEC563E16B147" modified="2022-05-25" version="1">MSISQDSAATIVCREVFDEASHPSNEEIIDHAKRIGINPITEPHLLDLAREGLMAPLPKGWTPCFHEIFKTCYYYEASTGTTTWEHPLDGKYKELVKAARASQSRQQSLDDDSKTFAKELESHEEATIPKEPPPSKHPPTKIPTKLAPLRKSVSDMGKRKDHRRSTSEARLTDRSARDYTNLQYQDPRFYESPKLLSPEGELNFRKIVKRSESMSPRYEKDWEQLSSKFSSEENVIDIDKLSASSLSKIDGKGDRFDKEKHPSQIMSRQKELTLTGGGSMFLKSNRSRDNTPSHEAAKFEDFQINSLSLERPKSILREKPPEDDDRHTEEERKSVRFDLEKNNLDDIKFTYSGSEDEDWNSEVSEPKSESKDDALDDKLGAKEPKNKPSSPGSKMVGNRFLVQEVSESEHLSQLKEDLDDLPTNKFTNIKNIDLFSKSDTDSTPRTGKNDSRSLETEAHLKKLRSDLEGVNKEKERNKRKDDDVKSAITRKHEREILGLKRELEERVERTRKEMEASFLEQRSQMEKLMEGKLEEFKSQLLLKEQEEINNLVAEMDETRRKNLEKVRSELEACYEKERQEIFVKLKNELDEKKQEMLELRNHEIEKMENEYDKTMDEEKILKMAEHDLAQKQNIKIEDMKKDLEKEFDDLRKKLRAEQREKMTKITEEHEKCLAEISRDYRVEENMARKVFKQKLDEIRSDLAREIDKETKKISDRATRQDSADYDKIRCEKRILEDKYKTLKDKYLKLKNDVRLAVEKRSKRKEGHTTASETEKSGSTRTRTERTESLTQNRTSSKNVSSSSKLEVNQNQNQNQNTVDNSESQQSFQRFSHGDSRSAKFESDDTTTASETMNSNILQKKKSHAKKTPTKLPLNNNNIADNPVENIRKQLEKLEDLGDQLPTNENAYTLRYPFQDKVPVNASSELEFFRHRIHVERDSVKRARETLRAQKNIFQGVQKAWKERSARATLEQLVQEERELSDMEVSLHRTKSLLGEKVIHLKHLEQSLERVANAKKNENDISPIKSDELTLSDISSASSGFSSTDLDKPDYYQESTEIIASLENLNSEIREIWNVLNKRRGNNVPPPPNLVGSDTRWFPFQHLTTQSNNIQGFGTPNIQSNILSQLTAHPPTTTQNIIAQYGPNSGFTTSVGTVDRGSNLIERTRNMRDWLRQARVETTDLISTGQATL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MTQ2</accession>
    <name>A0A8J2MTQ2_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Similar to La protein homolog (Aedes albopictus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HICCMSTLAB_LOCUS12826</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5107603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MTQ2"/>
    <dbReference type="OrthoDB" id="439993at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010494">
        <property type="term" value="C:cytoplasmic stress granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045727">
        <property type="term" value="P:positive regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08028">
        <property type="entry name" value="LARP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12291">
        <property type="entry name" value="RRM1_La"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045180">
        <property type="entry name" value="La_dom_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006630">
        <property type="entry name" value="La_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014886">
        <property type="entry name" value="La_xRRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002344">
        <property type="entry name" value="Lupus_La"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22792:SF166">
        <property type="entry name" value="LUPUS LA PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22792">
        <property type="entry name" value="LUPUS LA PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05383">
        <property type="entry name" value="La"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08777">
        <property type="entry name" value="RRM_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00302">
        <property type="entry name" value="LUPUSLA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00715">
        <property type="entry name" value="LA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50961">
        <property type="entry name" value="HTH_LA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51939">
        <property type="entry name" value="XRRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="HTH La-type RNA-binding" evidence="7">
        <location>
            <begin position="50"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="6">
        <location>
            <begin position="152"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="XRRM" evidence="8">
        <location>
            <begin position="263"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="237"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="365"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="33"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="251"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="365"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAG5107603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="400" mass="46615" checksum="7BB9178FBDB8FBD1" modified="2022-05-25" version="1">MEVVEKNSEKTAEETKMPVEEHVDGNNTSGDKNATDNKDEEKKAEEIKSVDASPELLEKIKNQIEFYFGDVNLQRDKFLIEQIKLDEGWIPMTIMLQFKLLAAMSNDVETILKAVEQSDLMEISDNRKKIRRRVDKPLPLYNEEYRRSQTARTVYLKSFPQEVKLDELKEFFKDFGVVENIVMRKYKDENQKLQFKGSIFVQFKNLDDAKALVAKESLKYKDTELIKMMSEDYSLMKTKERQERKGKKNEAEEDEDDESEKTDLPKGAVLHFTVEKPEGVVWEAIKQSFLEQEAKISFVDYKNGQKTGWIRFQGANSAIPLLEKMTDKKIKISDSEITFQLLEGEEEEEYLKKVRKELFIKAKPFNKSKKNRNNKKGFRKSKKRGGSPVQDEVASKKQAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MU47</accession>
    <name>A0A8J2MU47_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS14042</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001451">
        <property type="protein sequence ID" value="CAG5109527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="AlphaFoldDB" id="A0A8J2MU47"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="52"/>
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    <evidence type="ECO:0000313" key="1">
        <source>
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            <dbReference type="Proteomes" id="UP000786811"/>
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    </evidence>
    <sequence length="52" mass="5888" checksum="A2A3702E1F5B143A" modified="2022-05-25" version="1" fragment="single">MLELETEKSKRSQKIRETLFEENSNDSNSSLCLSLLDNSPVIYGCCSTDKET</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MY00</accession>
    <name>A0A8J2MY00_COTCN</name>
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        <submittedName>
            <fullName evidence="8">Similar to RSF1: Remodeling and spacing factor 1 (Homo sapiens)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HICCMSTLAB_LOCUS12189</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
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        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <property type="project" value="UniProtKB-KW"/>
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    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
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        </source>
    </evidence>
    <sequence length="4007" mass="442733" checksum="4D5A053A74A14302" modified="2022-05-25" version="1">MASDNEASCVSDPNFAVICSFLECFGKSCGIEYPDIKTLQKMIEDTHEVPQKLIDLHVKLLRKMKKTVHPEKWERVLVKFCHTYSNQDGWELERFGYKKARVSVKLRLLKVLLETQFDSNQRFKNDVNKQPASELRLEPLGRDKTGLAYWFQLDDDCNIRVYREDIDEESWELVATDREGVVKLINTLTAGEAGSLLTNEDSNSLEVSEKPIIDTGQAATSSPSAEQEPPVENGNASDSNAKSQGVKNPTTQEVKLAKPAAIEVNKKTSEAVVNNGVNVNDDENDSEGDDEEDEEDDDDDDDDEEDEDEEEEEGEGEEEEEEEEEEEDEELSNDASTQNTEEDGSQDVPPVNSNLKPVSNKITQPVNDNPVNAKRKPATVSEKDVPKDKPSVIKNPIEVTPLKSIETPVITSPLKLVPPPEPKHFTADLTTSVTISAVKPPPSLIEDSKARELAPSIKAHEKLPSKSSLPYSALEVTLNHGKFPLKPIDKLAANLVRMQSEKLEKPSASKLLEKIAENLARSSSSHPTNVMSNDDDKNKFPSDFISRLNVQEKHPIVGSSRSLRGGIDLSTSREWDNSIDHQQQHQQQHKQQRPVDFSGMDLSSRKQSKPIVEPLPSGYRAQEFHQYREMDLSTRKSKPDLAGPAYDSLLRNHSMIADLSKRQMPFVGYDMPSVAYHNPPVVRLPSKEEHRLPSYTILPDPSRLASMRSGAVKRALEIDETQQDMLKRLRADLSMGAMRGPIDKKAPLGMGLRREDIVGPAIEEPLMMVHGEGSGSDCDAGNQEVGDAIEEPVVFFYGEGAGRDCDTGNPGDESSDGGSKDSSGSQSKNGQGCSEVSAGISQSKLNNDNERDVAGVSNCPETSTSTSKPLELNNDCQLDPVTSNCQFESSESPKGKFKPTLGVQVIVKSPGCSAKRTSRWDVGRPDDKLECDSSISNEDNISEEPVVNDTGYQSNDVKSCGFKLETETISSTTNQSVESMSTDCNLPVVVPGNNLPVNETREEKMDMDVEKNCEGEDESPRFFFGPNCVSYTPSPGKRDQATSSSVKNDDKFVDNNNVKNMADSVIQPVSSSVNKPESSTEAEVCSTSDKIEKPEEVDSSVGGTLGEGTGESMDVSLEESSRSEDKIVDSNTEEVMNVDQVESSTDEKVLEPEDKVESSGESSRKIEADVEPEESSCIEEVDKLETKEATVESTIPELVEESPSAAAAVESSVPESSELEQSVETVESTVPEVLVKDDQVPVESSITESESSIPESSNVSMQSEEPSMVESTVSSDKDLENIRDIEKTNDSNDAFNYNVSEDQSMYGDQDSNDPMVIDEKDDLIESKNPGTESALNEENKDTEVDSSEVVEPSTSACPEIQDDIDFVSEKSEALEPGIELSKAQYEDVLKDLGDEQSEGKDCEAADSTTSKDASEFSESAETKSLLMSQTSLVANYGSDDSNDAGSDDVFVEKDKEVGKGEESKVTVPVEDKKDLVDTEETGLGSAEGVEELETEGKAEEGLVEGKELVEVEADKEGEDKEGSQAAEVTHEVLDDKKEAAESLELEDSKEAEDLVDEKIEGENSGVEEVKFVESVDLSVHEKESQVEENLAGEEKSELIKDLGAEIETVDLEVQEVKSQAAEAQEIESQAAEVQEVENRAAEVQEIKSQAAEEAIVESKASDSGENLAAPEIKSNESVEDPIVQEVKVVEPKESAVDDKIIEPEEGLASEKIQRIKPVEDVAEEIKTVEPVEDLAEEIKPVELVENLVSEEIKPIEPVENLTEEIKPVEDLIAEEIKSKDSVGPEVCLIEPEKDLKVKLNETVESCSSKAIKLNELVKENLPVEEITVNQITDLSVKESKLIDTQEPELIKLNLEKEIKTVEVEKDSTDLIPEAKSSLETQIEAEPLEIIEKESVKSIDTKESPAVTESIVEQVTNDLENTQESSSKKITLESEEKAIDSPACLTVGEKSLEPEIITNEPKDQPLDTLSVPENKAACKPIEEITVAEESISSDFSRVNSNKDPEGENKEDEEPIVQVCKRARTEPELTEIVLTKSPTTENVINENKVSSDTLLTQQASESTPVITNADNDYNKNLDDKKAANALDKVSPDLYIKDKASPEIIDLDKNLGADLKDSFDESVCKSSLVAPEDEKKEANKRAHIPVVNENPAPLKLRPRADLLREDSTFYNDMNASPDRKKDKVPEIQPVCNNIEEDDEIIEVPVENTAAVKLIDLTAPDVKLGYEDSDDSMGIDNECAFEPTEIDPLATTEDDVAKQIELDDLAVRVEPVNEVNKYEGWKLDSTETITLTPLKASRKRRNSNHESNSEDKAGKDVEEEETGGKRMRLRGKRTPDVALRKSVENSRIETVSSDDEAEEKNKEEEEESNEVTIVEVAKPKTFAKTKGRKKRGFKNKRKVIPPKKKVEVEKEVDQDIIEVPVENKVEEKKLEENNSKKKRKKKRMLLGLEIGIDIKPDAQPADGSDAPVRQSRRIAQIKIKEEADRRRIEEETLDPIKPKKIGGVVDKKKRKKKAESEEEVVVVKEIEKESKKKKKKRKKKKKKESKFNEAKPWQSSSGSSTEDENENEEEEDDIEEDIESEGSFLFKSDHEFSPESDLEKDEELEPMRRARTARKPDSDVEEADDEYACQKCGKADHPEWILLCDTCDKGWHCSCLRPALMLIPEGDWFCPPCQHKLLVNKLRESLKNYDQLAKRHQNEILRKKRLAFVGISLDNVLQKDGHRSHRVRQPREDDEDDESDEEDDNRDRDHRRGPSSSSSSSSGSSSESESSSEESEPVYQLRERRCVNTSYKFNEYDDMINAAIQDEVEAVQGAGNQGRGKDISTIVNAEKEEGKEAFSKKNDDDDEEEDDKQSDKDSDKDYTVDKEEEEEEDAEEKRKAAARKAAAKKKHRKLNSLDISSEDDPESDEDFKGSDSDEEEDYEDQMESSDDSSFTASRRRGGKKNHRPVRRSTRAARKTRYDEDFINDDSDDSDRPKRKRSKSTWEEESESEESDNSWRSRKKKSKASSFAKLKALSKSKAKKKKKRKRIIEPENKSEEENNENEGGNEEENGNDDGGEKEEVGKKEGEEVKEKEEKKEVVVANQGGNVGRVENEPEKEQEEEEEEEEEDEEEEEEEDDNGNDNDNGNDNEEEEEEEEEEEEGEKEEEMEQEEIPQPFLQPQIEQPVPLPIVEPPVVLPTVVSTVSADQVYEESKMVIDEDREEENHNQTEVVKPQVTSEYPVQEQVQQPAVMENELVEKKEKKRQKKSGIRRKIIYGGLPDDRPQEEEEPLGRRTRGRKINYQVDIIMSDSEEELKKALRKTEESEDEFMVHDGEDNHNNDDKDSDSGDIYSPKKDGPKGKNKSPKNRRSKKSPASRKGLTDNGEPKQRKKPGPKPGSKNKPRSLTGMMSLEGGVMGDVPEGSLTGLGSADLADLDEEQLEQMMMEDEEYGRRQLELAAIEIAKNKKKEEREAKKLEKARQKALEILAAEQQRDPNAPEGPDGEAPKKKKRGRRSKAEILAEQMRRDSMGAGTVPMPGPMDPNIPLTVNPVLGTAMPPEVMIQEMERPSPVEGHLPLITGPDGQLFNPDGSLVKPKRRGRGKGKKTLAMEAARAAEAAAKAAEAAGIVLDPELKDDIPNVLPTPGSSTSGSAPSTPPAGAVSSQGLPVTQSNPPGPQSVYSQLPPSQQSSVITRMLQSQPVSNAPQSFTAAAAAMGQKYFGVPNTTGPMMPNPRSSYDMSPRGRIPSPFNTRQPGQPPMPPHFAAVRSGNPPPIMRMRVPGPAQLYHTPHHPMDPSPSGGGPISISSRDRASPLGGGPMIPAAGSPLAKGGPTPPPYVRGPPISRFSDAQLAPRHQLPPFTSASPGNHALQQPSPPPNRPPGNFSPYHPQPPPNYHYGAYPPPAPMVTTADDAAYQGSPYSAEHFSTSSENPATQSPAIQPPPAAQTSQPPAPPTSHSSEPPHALPHPVPVAHGPAHGPHGPPGPPGHPPGHPGHPPGHPGHGKYDEEGSGEFGGLVSYFSSQREDDLDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MYC3</accession>
    <name>A0A8J2MYC3_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Similar to Cyb5rl: NADH-cytochrome b5 reductase-like (Mus musculus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HICCMSTLAB_LOCUS11499</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5103417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MYC3"/>
    <dbReference type="OrthoDB" id="432685at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06183">
        <property type="entry name" value="cyt_b5_reduct_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001834">
        <property type="entry name" value="CBR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008333">
        <property type="entry name" value="Cbr1-like_FAD-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019180">
        <property type="entry name" value="Oxidoreductase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19370">
        <property type="entry name" value="NADH-CYTOCHROME B5 REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19370:SF184">
        <property type="entry name" value="NADH-CYTOCHROME B5 REDUCTASE-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00970">
        <property type="entry name" value="FAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09791">
        <property type="entry name" value="Oxidored-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00406">
        <property type="entry name" value="CYTB5RDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0274">FAD</keyword>
    <keyword evidence="3 6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding FR-type" evidence="7">
        <location>
            <begin position="50"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="116"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR601834-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG5103417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="284" mass="32883" checksum="CADFFAC32C0EEB29" modified="2022-05-25" version="1">MLSNRPQSPKEEDCCGNSCNPCIFDVHKNLLKQWELKKLNSKSNNLLEPLVYKLFKVYELKQLNNDYISLILRYSDKEINDGRVIFNPGQHVVINYLKWSKPFTPISWTDDTIKFLIRIYADGINTKRLKNLESGELIKVRGPYGDFVYSRNKFKSIVMFSVGSGLAAFVPIIKSIIDDEEDETRVCLNAGFRSVDLVPLTKNLQLFTDYWNVECNLYLTEDASKKVNGINIEKGRIDEKICKCILDNYLASSSLVLICGTEKFNLSLERWIVEYNFVNYHVFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MYT8</accession>
    <name>A0A8J2MYT8_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS11981</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5104396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MYT8"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5104396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="145" mass="15848" checksum="8FE64AFC7C7D164D" modified="2022-05-25" version="1" fragment="single">ILCDKLLKASIVCDLLIVESSVVKCSPSVSGLTTYSVGKLSCGTTVTDSDLFTVEVKLVILETMFVKASITPPIIPVTRVLLFFSSELLFSDSSLESSEYSACKRSPRPKIFGAFPWIRTEPSLLPIIVLIPPLKRFSSFTLNVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-24" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>B9W495</accession>
    <name>B9W495_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Cc_HzNVorf9_2</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">HzNVORF9-like2 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">HzNVorf9-like2</name>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS5436</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2009" name="Science" volume="323" first="926" last="930">
            <title>Polydnaviruses of Braconid Wasps Derive from an Ancestral Nudivirus.</title>
            <authorList>
                <person name="Bezier A."/>
                <person name="Annaheim M."/>
                <person name="Herbiniere J."/>
                <person name="Wetterwald C."/>
                <person name="Gyapay G."/>
                <person name="Bernard-Samain S."/>
                <person name="Wincker P."/>
                <person name="Roditi I."/>
                <person name="Heller M."/>
                <person name="Belgahzi M."/>
                <person name="Pfister-Wilhem R."/>
                <person name="Periquet G."/>
                <person name="Dupuy C."/>
                <person name="Huguet E."/>
                <person name="Volkoff A.N."/>
                <person name="Lanzrein B."/>
                <person name="Drezen J.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <tissue evidence="2">Ovary</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5089944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FM201570">
        <property type="protein sequence ID" value="CAR31583.1"/>
        <property type="molecule type" value="mRNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B9W495"/>
    <dbReference type="OrthoDB" id="7654815at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5089944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAR31583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="237" mass="27419" checksum="81EC62EB98F102D4" modified="2009-03-24" version="1">MASAESLVEPLDPDDSYQKLLKLSEVGGGVLHNFYGIDKAAFNINIIDKIVSLCQKKEYGIKDLLDLRDIVNLTIFNQYIEEKNIDRINQLEKYIDVYLSAICRYRSQNYHFVRNKLLPLLRLKTKPPFSEPDLIAKGTVSLKYPESDAKRKINNNIDIIQMIRSQQAHIRNTSYELLVYNNRSNIYGSKQIILTGSVFVTLATSLINLQNVMLKNNNEMGFYVRPFLEVHTLKWEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>S6CVN4</accession>
    <name>S6CVN4_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Cc_single_36.5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">CcBV_36.5</name>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS6108</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Philos. Trans. R. Soc. Lond., B, Biol. Sci." volume="368" first="20130047" last="20130047">
            <title>Functional endogenous viral elements in the genome of the parasitoid wasp Cotesia congregata: insights into the evolutionary dynamics of bracoviruses.</title>
            <authorList>
                <person name="Bezier A."/>
                <person name="Louis F."/>
                <person name="Jancek S."/>
                <person name="Periquet G."/>
                <person name="Theze J."/>
                <person name="Gyapay G."/>
                <person name="Musset K."/>
                <person name="Lesobre J."/>
                <person name="Lenoble P."/>
                <person name="Dupuy C."/>
                <person name="Gundersen-Rindal D."/>
                <person name="Herniou E.A.Drezen.J.M."/>
            </authorList>
            <dbReference type="PubMed" id="23938757"/>
            <dbReference type="DOI" id="10.1098/rstb.2013.0047"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5092389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="HF586473">
        <property type="protein sequence ID" value="CCQ71158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S6CVN4"/>
    <dbReference type="OrthoDB" id="10399186at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5092389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCQ71158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="84" mass="9640" checksum="31944BE9187B7028" modified="2016-04-13" version="1">MIQIVILMIRCIAELAINRISKENDYTAYSHNNDKYPHSNDIVFSVYELADRNSLATLSEINYYECPLALTETRSLLLCTANTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-10-16" modified="2023-09-13" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>S6CWE9</accession>
    <name>S6CWE9_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Cc_bv5.5_25.5b</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">bv5-5</name>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS6055</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Philos. Trans. R. Soc. Lond., B, Biol. Sci." volume="368" first="20130047" last="20130047">
            <title>Functional endogenous viral elements in the genome of the parasitoid wasp Cotesia congregata: insights into the evolutionary dynamics of bracoviruses.</title>
            <authorList>
                <person name="Bezier A."/>
                <person name="Louis F."/>
                <person name="Jancek S."/>
                <person name="Periquet G."/>
                <person name="Theze J."/>
                <person name="Gyapay G."/>
                <person name="Musset K."/>
                <person name="Lesobre J."/>
                <person name="Lenoble P."/>
                <person name="Dupuy C."/>
                <person name="Gundersen-Rindal D."/>
                <person name="Herniou E.A.Drezen.J.M."/>
            </authorList>
            <dbReference type="PubMed" id="23938757"/>
            <dbReference type="DOI" id="10.1098/rstb.2013.0047"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5092329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="HF586472">
        <property type="protein sequence ID" value="CCQ71082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S6CWE9"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5092329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCQ71082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="100" mass="10781" checksum="64BBCFB7E2EA904C" modified="2013-10-16" version="1">MIINTTFSFTVFPNGCSTGLAYAKSRKMAGMSSILDGMGTVMDFVHNIIPGSNSNQQYGGKPQVIYGSVTNTKGNHFRNTNIKGSISYGSNTVQTGNRYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-10-16" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>S6CWN7</accession>
    <name>S6CWN7_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Lysosomal Pro-X carboxypeptidase</fullName>
            <ecNumber evidence="14">3.4.16.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Proline carboxypeptidase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">Prolylcarboxypeptidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="primary">prcp</name>
        <name evidence="19" type="ORF">HICCMSTLAB_LOCUS7312</name>
    </gene>
    <organism evidence="20">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2013" name="Philos. Trans. R. Soc. Lond., B, Biol. Sci." volume="368" first="20130047" last="20130047">
            <title>Functional endogenous viral elements in the genome of the parasitoid wasp Cotesia congregata: insights into the evolutionary dynamics of bracoviruses.</title>
            <authorList>
                <person name="Bezier A."/>
                <person name="Louis F."/>
                <person name="Jancek S."/>
                <person name="Periquet G."/>
                <person name="Theze J."/>
                <person name="Gyapay G."/>
                <person name="Musset K."/>
                <person name="Lesobre J."/>
                <person name="Lenoble P."/>
                <person name="Dupuy C."/>
                <person name="Gundersen-Rindal D."/>
                <person name="Herniou E.A.Drezen.J.M."/>
            </authorList>
            <dbReference type="PubMed" id="23938757"/>
            <dbReference type="DOI" id="10.1098/rstb.2013.0047"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Cleaves C-terminal amino acids linked to proline in peptides such as angiotensin II, III and des-Arg9-bradykinin. This cleavage occurs at acidic pH, but enzymatic activity is retained with some substrates at neutral pH.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>Cleavage of a -Pro-|-Xaa bond to release a C-terminal amino acid.</text>
            <dbReference type="EC" id="3.4.16.2"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Lysosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase S28 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.16.2" evidence="14"/>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5093986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="HF586476">
        <property type="protein sequence ID" value="CCQ71326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S6CWN7"/>
    <dbReference type="OrthoDB" id="2130629at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008239">
        <property type="term" value="F:dipeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004185">
        <property type="term" value="F:serine-type carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.980:FF:000002">
        <property type="entry name" value="lysosomal Pro-X carboxypeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.980">
        <property type="entry name" value="Serine carboxypeptidase S28, SKS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008758">
        <property type="entry name" value="Peptidase_S28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042269">
        <property type="entry name" value="Ser_carbopepase_S28_SKS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11010:SF38">
        <property type="entry name" value="LYSOSOMAL PRO-X CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11010">
        <property type="entry name" value="PROTEASE S28 PRO-X CARBOXYPEPTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05577">
        <property type="entry name" value="Peptidase_S28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 20" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0458">Lysosome</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 18" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="18">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036287026" description="Lysosomal Pro-X carboxypeptidase" evidence="18">
        <location>
            <begin position="25"/>
            <end position="497"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00052013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00059701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00066456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00073691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00076475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00076608"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="CAG5093986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="CCQ71326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="497" mass="56133" checksum="F5DE77BF638B18D4" modified="2013-10-16" version="1">MDYKAYNFTLLSFILTIQFIKLNSLQVITASTEVTKSNSSPYKYVTKKFTVPVDHFSFSINNTFEMRYFINDTWRSGKNPPIFFYTGNEGDLETFAENTGFMWDIAPTFGALIVFAEHRYYGESKPFGNKSFDNVKNLGYLTSQQALADYVDLIVHLKSDPSLKHSPVIAFGGSYGGMLSAWFRMKYPHIIHGAIAASAPVLQFTGYTDCQSFSRIVTSDFRAVDPNCEKVIRKSWESIKNLTSSDDGKKWISTKFKVCGSLTTNENFKTFKDFLVSIYSNLAMVNYPYATDFLSPLPPYPIREFCKFLNNTNLSSDKDVLTNLQKGINLYANYTGKLKCLDLSNPEPDLGAASGWDYQACTEMVMPMCNDGVNDMFEPEPWNFTEFSENCFSHFNVTPKPDLVCNIYGCDDLSTASNIVFSNGLLDPWSSGGVLRNVSSSAVAIIIPEGAHHLDLRGSHPADPYSVIKAREYHIYSIKKWIKQYRESFNNDTVFAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>S6D4P1</accession>
    <name>S6D4P1_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cc_ep1.4_5.5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">ep1-like4</name>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS6076</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Philos. Trans. R. Soc. Lond., B, Biol. Sci." volume="368" first="20130047" last="20130047">
            <title>Functional endogenous viral elements in the genome of the parasitoid wasp Cotesia congregata: insights into the evolutionary dynamics of bracoviruses.</title>
            <authorList>
                <person name="Bezier A."/>
                <person name="Louis F."/>
                <person name="Jancek S."/>
                <person name="Periquet G."/>
                <person name="Theze J."/>
                <person name="Gyapay G."/>
                <person name="Musset K."/>
                <person name="Lesobre J."/>
                <person name="Lenoble P."/>
                <person name="Dupuy C."/>
                <person name="Gundersen-Rindal D."/>
                <person name="Herniou E.A.Drezen.J.M."/>
            </authorList>
            <dbReference type="PubMed" id="23938757"/>
            <dbReference type="DOI" id="10.1098/rstb.2013.0047"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5092350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="HF586472">
        <property type="protein sequence ID" value="CCQ71100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S6D4P1"/>
    <dbReference type="OrthoDB" id="6929542at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036287024" evidence="1">
        <location>
            <begin position="19"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5092350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCQ71100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="281" mass="31654" checksum="AD444CB9FB5E964C" modified="2016-04-13" version="1">MFGKVGFVLAALIATSLGKVTESVNNAEPVNIEPVNTEPVNTEPVNTEPVNNIQWVPPSTEQFPQNHKIVLMLNCSSLTGNKIELIDTEFRAIERPCRLRAPEVLLKNNLFWSSESNFEILADNVTIEHNGFFGSEQDHRISAYEVKMIDNVYIGQHQIHEIYGPNIMKSRNVYDGNFQVHHITGRNIMENKEIIRGMYWSHRKSPMIQIVPGKGSGAIKKFVTLPMNVIETGNNFGGIHRNKLPSGSGLRHLLNGLKNRRNPNAPIVRQIVDLYDAPLSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-10-16" modified="2025-04-02" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>S6D4Y2</accession>
    <name>S6D4Y2_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Hypothetical transmembrane channel-like 7 TMC7</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="9">Similar to Tmc7: Transmembrane channel-like protein 7 (Gallus gallus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">tmc7</name>
        <name evidence="9" type="ORF">HICCMSTLAB_LOCUS7351</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2013" name="Philos. Trans. R. Soc. Lond., B, Biol. Sci." volume="368" first="20130047" last="20130047">
            <title>Functional endogenous viral elements in the genome of the parasitoid wasp Cotesia congregata: insights into the evolutionary dynamics of bracoviruses.</title>
            <authorList>
                <person name="Bezier A."/>
                <person name="Louis F."/>
                <person name="Jancek S."/>
                <person name="Periquet G."/>
                <person name="Theze J."/>
                <person name="Gyapay G."/>
                <person name="Musset K."/>
                <person name="Lesobre J."/>
                <person name="Lenoble P."/>
                <person name="Dupuy C."/>
                <person name="Gundersen-Rindal D."/>
                <person name="Herniou E.A.Drezen.J.M."/>
            </authorList>
            <dbReference type="PubMed" id="23938757"/>
            <dbReference type="DOI" id="10.1098/rstb.2013.0047"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMC family.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5094025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="HF586479">
        <property type="protein sequence ID" value="CCQ71377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S6D4Y2"/>
    <dbReference type="OrthoDB" id="1936208at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008381">
        <property type="term" value="F:mechanosensitive monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038900">
        <property type="entry name" value="TMC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012496">
        <property type="entry name" value="TMC_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23302:SF24">
        <property type="entry name" value="TMC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23302">
        <property type="entry name" value="TRANSMEMBRANE CHANNEL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07810">
        <property type="entry name" value="TMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="195"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="297"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="390"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="448"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="483"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="594"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="644"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="701"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="domain" description="TMC" evidence="8">
        <location>
            <begin position="529"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="69"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="79"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF07810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAG5094025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCQ71377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="779" mass="89882" checksum="94306B3C5B6E2312" modified="2013-10-16" version="1">MSGGERKKRGGDKGQGWEEAGAEFYQERYPAAIENDLQQALRDPSHIATLLPSKKSRVATAKRIRNEPKTTMRRRTSTRSRCATSTARRMSTNAPNIDTAVSMLPDLSENLSNEERTWEEIMQIKAMPVCMAQKIQLKRQLQNATKLRLQGFEQLKWQRRKAWQQFKARMKETYAKMELWSTSFKKIGGNFGMGIVAYFLFIKWLMFLNITLFIVIFAFIILPTIVLVEEPEPCTGNSSTSVSCSSEAYWNSSESGNTFVDIMQARGILERTLLFYGAYTNQIYGKNGNGTYYDLPLAYICTIIAVTLISLIAIIRSAAKGFKERVVEGEGQFYQYCNLIFGGWDFCIQNEKAAGIKHKALYNEIKAFLEAERLEEERQNRTREERIKLFFVRLIVNLLVILVLSTCGVFIYFIIELSFDKVEDPGSSQAESSSYISIERLVQIAYEFLPYVCIVGLNIVVPFLFRYLVALEHYNPLFVVRLTLFRIVFLRLASLAVLLTSFYKKISTPEEDNEQPRHVSNANHHRPQCWETFVGQQFFKLYLTDFFTQFLVTFFINFPRSLIARHSENKFIRFIGEQEFDLPRHILDIVYSQTICWVGMFFVPILPLISTIGCFILFYIKKFSCLVNSTPSSQVYRASRSNSLFMFVLLVSFILAISPVAYSIAEIEPSKSCGPFRGLHTVWELIIQTFLRFPEWIRRTLFFLGTAGFGIPAFIALSLLLYYYHAVSDANKHMVVVLKNQLVLEGHDKQFLLNRLSAFIKQQQEQSKYQEQAIDMNNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-10-16" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>S6D9J6</accession>
    <name>S6D9J6_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cc_bv19.2_13.1b</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">bv19-2</name>
        <name evidence="4" type="ORF">HICCMSTLAB_LOCUS6117</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="Philos. Trans. R. Soc. Lond., B, Biol. Sci." volume="368" first="20130047" last="20130047">
            <title>Functional endogenous viral elements in the genome of the parasitoid wasp Cotesia congregata: insights into the evolutionary dynamics of bracoviruses.</title>
            <authorList>
                <person name="Bezier A."/>
                <person name="Louis F."/>
                <person name="Jancek S."/>
                <person name="Periquet G."/>
                <person name="Theze J."/>
                <person name="Gyapay G."/>
                <person name="Musset K."/>
                <person name="Lesobre J."/>
                <person name="Lenoble P."/>
                <person name="Dupuy C."/>
                <person name="Gundersen-Rindal D."/>
                <person name="Herniou E.A.Drezen.J.M."/>
            </authorList>
            <dbReference type="PubMed" id="23938757"/>
            <dbReference type="DOI" id="10.1098/rstb.2013.0047"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5092403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="HF586473">
        <property type="protein sequence ID" value="CCQ71165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S6D9J6"/>
    <dbReference type="OrthoDB" id="10334731at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036287027" evidence="3">
        <location>
            <begin position="23"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="144"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG5092403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCQ71165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="193" mass="21127" checksum="279790545E3AD66B" modified="2013-10-16" version="1">MLANKSVIVLCISIFSVSWIQAIPDGKEAEGLSLPEDFARWFGEQSFKAITDEDRSLNDSVSRLTTSTINYSFSDEGSGQDDSFTDDGSGLPASTAEDDFSEVTSPLPVTTTEDFTFKEPASTSVMIKDASEKSRNAGQHSPSVIIIVVSICAVILLLILFTVVKIYCLRYKVSQEENAAKEPFIRFSKVTTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2EA13</accession>
    <name>A0A8J2EA13_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Similar to Nep2: Neprilysin-2 (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HICCMSTLAB_LOCUS275</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase M13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001114">
        <property type="protein sequence ID" value="CAG5073312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2EA13"/>
    <dbReference type="OrthoDB" id="7651858at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08662">
        <property type="entry name" value="M13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1380.10">
        <property type="entry name" value="Neutral endopeptidase , domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000718">
        <property type="entry name" value="Peptidase_M13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018497">
        <property type="entry name" value="Peptidase_M13_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042089">
        <property type="entry name" value="Peptidase_M13_dom_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008753">
        <property type="entry name" value="Peptidase_M13_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733:SF240">
        <property type="entry name" value="GH14155P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733">
        <property type="entry name" value="ZINC METALLOPROTEASE FAMILY M13 NEPRILYSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01431">
        <property type="entry name" value="Peptidase_M13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05649">
        <property type="entry name" value="Peptidase_M13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51885">
        <property type="entry name" value="NEPRILYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035158983" evidence="9">
        <location>
            <begin position="24"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M13 N-terminal" evidence="11">
        <location>
            <begin position="66"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M13 C-terminal" evidence="10">
        <location>
            <begin position="503"/>
            <end position="687"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF05649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAG5073312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="689" mass="79108" checksum="5467464E70A19647" modified="2022-05-25" version="1">MKPQKSSVVYLIAALGFAGLVVPNHGAALTSPAKPGEHKCTSDECIVERLDTATHVMKFRDSNVNPCDNMYRFVCGKYDGTDVSHTPSAEIQMRNAIMNSFIGVVDALTSDFRPFKMIEELHDICTDDNARNQDSVNLMKGVIMHMGGWPLVDGDKWKEADFDWMNFSGESKKSGYPINYFVDFEPLLDVEEDGEKIMVFKAHPSPQFFKYAAEMMKTPEPYKEYIMTIAKLLGATGDISKDVDDLIEFQKKVQAIDADHDDKTDKKMSIADLQIEFPGIDWNTWASKTLIPFMDKGDEPVITIWNREAMKAFIKLMAETPKRVQANYAIWRMVQKSVSFLTPEFRKEQDKFWETIGYQEVSEETFCDDTAKFYMEEAMKYFFIDQFKNSAESMQNLVQDMKDSMVAMMKDCKHLDAEDKEKGSKVVSEMPVTLGSSTRFSDPKELEAFYAESEFHKNNFLQTLLNLNMFRIEIDYSKKLQKDLNFVNDQPEGLETPRNIHDHLFIPPEILDSPMFDNNRPMYMNYGAAGPNIGRELFVSVYQHTKLKDEDKQSTLMKQIKCFENMFGNFTNTDVKEDMDLGTMSTMMGQFIGLRSAYKAYKDYEAKNGAEAPLPEVPHTPEQLFWMAYVGQFCKANVDVEKEDDIEGIEMKMMEFIMQKMLAQIPEVAQDFSCPAGSKLNPETKCEWW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2EA51</accession>
    <name>A0A8J2EA51_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS1199</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001116">
        <property type="protein sequence ID" value="CAG5074988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2EA51"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5074988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="159" mass="17539" checksum="697A15D01A9F781B" modified="2022-05-25" version="1">MRTSWPSQSRAPAALIINLSVFCLLITGNVPDWSFYATELTNLLSSSSDSRLIASVIFKVWPTKPGIFVLAPSVPTNYQNNADQADPPVACSAYRTRPKTETSTQDPSTEPPASQDVPSLGDGGLDNFNNSDTRPMLSYSMLMQLYRRNYDEAQKNISQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2EBC2</accession>
    <name>A0A8J2EBC2_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS985</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001114">
        <property type="protein sequence ID" value="CAG5074254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2EBC2"/>
    <dbReference type="OrthoDB" id="7700419at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd19941">
        <property type="entry name" value="TIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="127"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="127"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="153"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5074254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="375" mass="39073" checksum="89FE854617E0A45B" modified="2022-05-25" version="1">MTHVNCAKGCGKHEEMNNCGSLCEPSCSNQNPDCGFGPGVPPSCGPGPMRKCRCQSVLCLVGVGELASGAKIFGGASIDSQAAGVQAGLTFPKIPGFNSPIFGISILPTASSNNTWDVFSNLFPRISSNDNDSVSSDGNRNGNVTIGQNQQGTTTPSSNQNESTTTSSSNQNQTSTTPSSNQNQTTTTSSPNQNQTTTTSSSNQEETTTTTTTTTTTTTTPSSTQSSTTTQRSVSSFIKRALTSMLPNINSLVPTLRNLTGNITLPSIQGPPSLDSLPQIPGLSDAIAEAREHVRIALNATGDFVDGIETALQQALQSNNPTEAVRTLVNTILNAYLVVALNCPMIVVGTRVLREGIRLAGEVARSARNVVFGAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2EBX2</accession>
    <name>A0A8J2EBX2_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Similar to Cep135: Centrosomal protein of 135 kDa (Mus musculus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HICCMSTLAB_LOCUS1188</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
            <location evidence="1">Centrosome</location>
            <location evidence="1">Centriole</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the CEP135/TSGA10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001116">
        <property type="protein sequence ID" value="CAG5074977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2EBX2"/>
    <dbReference type="OrthoDB" id="10254663at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005814">
        <property type="term" value="C:centriole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051877">
        <property type="entry name" value="Centriole_BasalBody_StrucProt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20544">
        <property type="entry name" value="CENTROSOMAL PROTEIN CEP135"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20544:SF0">
        <property type="entry name" value="NUCLEOPROTEIN TPR_MLP1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAG5074977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="97" mass="10661" checksum="BBBF7E5F2FBD5D96" modified="2022-05-25" version="1">MCDSVESYTIGAKYRTVKKRLDSLGYKHSLSLDSLSLVEQLLADLIKTTESLKHFKSVAANNTEVDDQLTIPQTTVLETTVPRTTVPGTIVPKTIVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2ECU8</accession>
    <name>A0A8J2ECU8_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Similar to Rbp6: RNA-binding protein Musashi homolog Rbp6 (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HICCMSTLAB_LOCUS1216</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Musashi family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001116">
        <property type="protein sequence ID" value="CAG5075021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2ECU8"/>
    <dbReference type="OrthoDB" id="1875751at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12323">
        <property type="entry name" value="RRM2_MSI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000320">
        <property type="entry name" value="RNA-binding protein Musashi 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000314">
        <property type="entry name" value="RNA-binding protein Musashi Rbp6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034126">
        <property type="entry name" value="MSI_RRM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48032:SF4">
        <property type="entry name" value="FI20028P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48032">
        <property type="entry name" value="RNA-BINDING PROTEIN MUSASHI HOMOLOG RBP6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="8">
        <location>
            <begin position="40"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="8">
        <location>
            <begin position="128"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="13"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="301"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="21"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="308"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAG5075021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="353" mass="37544" checksum="3910B0BE39CE5292" modified="2022-05-25" version="1">MEAANGAIDHDFHNTLVPINGSHSGSSGRSTPNSGDPAPGKLFVGGLSWQTSSEKLREYFGMFGTVTDVLIMKDPVTQRSRGFGFITFAEPGSVDKVLKCPIHTLDGKKIDPKHATPKNRAKQANRTKKIFVGGVSQDTSSDEVKAYFNQFGKVEETVMLMDQQTKRHRGFGFVTFENEDVVDRVCEIHFHTIKNKKVECKKAQPKEAVQQSALALGKRVVLGALGVRLAPQPPLQVATASQIVAAQAQAQVQAAAAAAAAAQVQNAVAGYGKLFASSYPALSAYRYAPYPIPAAAVAAPPQAPAPPTAANTAPQQAAAAPGNPYQGYSLTNVDMSSFQGVDWGSMYGMGMYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2EFJ3</accession>
    <name>A0A8J2EFJ3_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transcription initiation factor TFIID subunit 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HICCMSTLAB_LOCUS538</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat TAF5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001114">
        <property type="protein sequence ID" value="CAG5073642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2EFJ3"/>
    <dbReference type="OrthoDB" id="10266330at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000243">
        <property type="entry name" value="Transcription initiation factor TFIID subunit 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19879:SF1">
        <property type="entry name" value="CANNONBALL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19879">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3 9" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="12"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="54"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="87"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="119"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="161"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00044130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAG5073642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="255" mass="28388" checksum="4E7EB51F94F8B3E6" modified="2022-05-25" version="1">MDERTAETVKLLHGHSGPIYSLTFSPDRNLLLSCSDDATIRLWSLHTWTCVVCYKGHLFPVWSVRFSPHGYYFATGSNDKTARLWVVQFHPNSNYVASGSSDMTVRLWDCVTGAQVRLMTGHKAPIYALSFSTEGRFLASAGADSRVLVWDLAHGHLVGALSGHTSTIQCLSFSRDGTILTSASLDCTIRLWDFTKLTEEMVLDDVNVAHNPDVKSTSDSYLLRTFPTKNSPVLALHFTRRNLLLSVGMFEAQKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2EGF5</accession>
    <name>A0A8J2EGF5_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HICCMSTLAB_LOCUS1114</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001116">
        <property type="protein sequence ID" value="CAG5074902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2EGF5"/>
    <dbReference type="OrthoDB" id="60433at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050745">
        <property type="entry name" value="Multifunctional_regulatory"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24189:SF50">
        <property type="entry name" value="ANKYRIN REPEAT AND SOCS BOX PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24189">
        <property type="entry name" value="MYOTROPHIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="30"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG5074902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="487" mass="57054" checksum="E7F59611300F8651" modified="2022-05-25" version="1">MYLALQIAFDLIPQNGINVNEPIITSGEFAGFTALHVACMKNKDDLVELLVNNYKADVNAMAADGTEPIHLACFYVPLDGQRDMRFIIRTGIKTIKILVEANANVNAKFGEGIFSKHVKNRKWCPDFGDKIPLVAYAVIYDKPLIIGLLKKVNVDIISLKNKTLLMYLVEQRCELFISDIMSNVEDPELMDKLMNHRDDDDDVPLSHYPLHPKQYGKFQYVKHFVLDDYDYFESDFFSELSNWGADMHALINNDPITFLPNLLAYRSCPMLEDLLPYYTSMSLPRVLYYATLPVDENSEHLIKTNSNRERLTYLERIRRNQKECIAIVLKDLVFRSEFRSPVPEQEAKLMDELIAKDEYFRKIVDDFKRNFIEKEFQERFIEFGDNKMTMYDLFKQVFDDKKVKLLAREENLLDALDEIVWQKVNVTRFLYSDIYREPIKLRIKNAKERVRLVENLKKISSLREAIPLPFEVVLDIVDLDEQFSRFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2EJM0</accession>
    <name>A0A8J2EJM0_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Serine protease gastrulation defective-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HICCMSTLAB_LOCUS1245</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001116">
        <property type="protein sequence ID" value="CAG5075073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2EJM0"/>
    <dbReference type="OrthoDB" id="238681at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000068">
        <property type="entry name" value="transmembrane protease serine 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051333">
        <property type="entry name" value="CLIP_Serine_Protease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24260:SF143">
        <property type="entry name" value="SERINE PROTEASE GD-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035279739" evidence="2">
        <location>
            <begin position="22"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="3">
        <location>
            <begin position="193"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG5075073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="466" mass="53099" checksum="7ED98588C2E82BF7" modified="2022-05-25" version="1">MSGVCKLLVIVFIINITTVKCYYNSSCSEIVSNIRHPKRNDTLVRIKIPNPPKNFRQLTLKVLYETREKFKNDYHGFINLRWPLAETMDRITSGKSLIYIVHLPMLLRIPHIIFVSLNDTPLCIIKKDPLKRVVELKHNLLPPQFNPASLPIISTTEATSTTSTTEAPYIDEMPKSSEPEGPDTFFRKELDELSKGCGHINSDDNFEFKDNVRLRQRQWPWLAAIYINSSTSEFHCSGTLISDRHILTAGHCTYYNDRKLTPNLLVVSLGRYRLDDWEEPLSDNYEVSSIDVHPDYNFGLTSEADLAILKLSRRVRFRPTVRHLCIKTDFEQGFGPTEELGYVAGWGDKTLASKENREIVEESSVAKLHVAPIISPEKCVNETRKLEKFITDNTFCARSPNGVSGPCNSDSGAGLAVAVFQKFYLRGVVSMLAVGKTALDCDHKDFVVYVDVYTYTYWILLKIFEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2ELR7</accession>
    <name>A0A8J2ELR7_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS106</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030000631">
        <property type="protein sequence ID" value="CAG5071957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2ELR7"/>
    <dbReference type="OrthoDB" id="7697653at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5071957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="124" mass="14714" checksum="9598BF11573895F8" modified="2022-05-25" version="1">MHHDFVYMGMMFGHVVNQVIEFLREYPFQFVIIFMQEEYVSEASTMTECEILENIYIKRLGNLFFQSWSVKGTIEKHHGKILLGRGNRSFGKCTINLACEQQNKWKITPSFTRSEMECYSFFSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2ELY9</accession>
    <name>A0A8J2ELY9_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS289</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001114">
        <property type="protein sequence ID" value="CAG5073340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2ELY9"/>
    <dbReference type="OrthoDB" id="7699082at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="116"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="496"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="718"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="161"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="173"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="215"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="254"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="275"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="289"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="317"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="379"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="499"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="727"/>
            <end position="746"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5073340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="746" mass="86130" checksum="ADA474D9869E437D" modified="2022-05-25" version="1">MDCHRKMIVRPTQNYKPKENVADEDEDDLEALRLAALMSLKAKPSKIPPPPQKSFVPPGNSYPMYNSNNNIKNHGSYRGRRDFYQNRPLVRQNGNQNAYHPSRNNQNLIEIIPMEENAPKDGEDKKDTAASEKENSKFRRYDDASGSEDEDIKPKPTLEQPSSSLGDLGNLDDLGDLPDLPDSEPPKEDSQTDSDPGEASESGLPDSNSPKEEEPLPTEENEEENPDSDNEAEKEEEDDDDVLLMADYEEEDSLERLMDEMEREMADKPLEKKEKKPRKDKVKKDKPKASSISASTSTVSNLSYKVPKSPEAPYERPRHRSPSPKAKRKKSPRRSPARLKKLRRSPRRSPIRSPKRLMSPRRRSRSRSRSPIRSRRSPRSPIRNSRSPKISPRRISPRKISPNSPIHSPWTSPINSPKRRRSPIGSLINLNLNKEKEEKSRRKRSNSPEDNLNFKNKIEKETEISDPVLEARRRKFESTKLIDPVNDNKKIKLSRKLEEEENVEEEKLEDDVEEGEVQEISDEEKIENEEVQEEDVALCLDESYDLDELEEHVSDEAVFETVKVEKKVKKKKKKDKEIYQVGKLKELPLSERLGKEKKCKKRKEYDGKAEEGNCEEVVDEEADLRTELSRRRAERLNRNAPIQSARLLQSAFKGVVNEVAKSNSKVLQRQLIKEDKHPQKEIRRVTLLHRSIPELHDSEDEMIDSKVPIKFRLGLNKVQETRETKSSRKSSKRQGRKVKHKNLIVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2EP86</accession>
    <name>A0A8J2EP86_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Similar to Srebf2: Sterol regulatory element-binding protein 2 (Mus musculus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HICCMSTLAB_LOCUS2314</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001117">
        <property type="protein sequence ID" value="CAG5076895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2EP86"/>
    <dbReference type="OrthoDB" id="2133190at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11394">
        <property type="entry name" value="bHLHzip_SREBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.280.10:FF:000098">
        <property type="entry name" value="Sterol regulatory element-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46062:SF1">
        <property type="entry name" value="LP12374P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46062">
        <property type="entry name" value="STEROL REGULATORY ELEMENT-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="BHLH" evidence="12">
        <location>
            <begin position="265"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="105"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="344"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="114"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="349"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAG5076895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="1021" mass="113780" checksum="F292DC5372AA4B6E" modified="2022-05-25" version="1">MGDSGGTWSSIQDTEFPNFTAGDTFNLNDVTGFDDLLKNCESELMKNEHLFGDETFLSDLSDPIAMENDQFNFLDMNIDNDFKDTNLMGKLVEPNVMVMASNAAQVPQQVSPPQQSPQPQPQPQQKPQQHKRHASVPDGQLPNQPKKLATHPASPAPTVFASQYTLPQNVNFTLKSPVVTLAPVNTNQRQLLLPAKLIKSESVVYPRGSQAITSTPVPHQIHTFVNAANGTVLATGIPVVLDTDKVQINRMNTSPAVGVPKVREVKRSAHNAIERRYRTSINDKIIELKNITVGVDAKLNKSAILRKTIDYIRFLQNSNAKLKAENMAMKMAAQRQNLRDLLSCGELTPPRSDSSEPSLSPAPAPLSPASPLSIKEEPDNFQHKPQHSVNGLGDHTRLTLCAFLLVFIAFNPLQFAINKVGRFNSDLGESKFDGRTILTHEEPTEPASIVWNSIILWFVNALLLIGGLYRLLLHGDPVIPTESKTFLELRRWRHQAEFNMSINDNEKAHSDLRRCLGYFNRTLPSSRMEIGLTTLWQIVRQILYRLWIGKWILHAGKWLSQSSERQQTEISTMELAMVYQRILCLRLSEGSSNATLFLALSAVNYAEAAGECIPKVSLAEVYINAALCFKQSMFSLVHKYYFNKARAVLATCVVPSKFKWIMTNEGAKFFTSHKWQYGDCPVSEFTSQSIKTDPLSFTARAYREYLVGQCLRLLTGTAGDSHASTILALAENIIASADVEIGFPTQSSNGQDREDPIGLWWGAVFCAAANWRLGNEDSSWTLVESKFPYGKNYNKNDASSNGNPLPYAVLCVLQAAKRSTRSSIRLVDQAGEYLQHSMVYYHCKQQSPHNVQLVQLWLCDCLLELRTVLWQGLGGETGQTAVNTFLAAFQRDLARLRQLSQYIPSVLPRIFLYEATARIMAGATPVKTQLLLDRSLHHRNSRSSIICGKDRSHENGNGEREHAAALCLACRHLPVLLLASPGERAGMLAEAAKTLERIGDRKKLQECYELMRQLGPAISAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H029</accession>
    <name>A0A8J2H029_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Defensin5_Cc</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HICCMSTLAB_LOCUS1444</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001116">
        <property type="protein sequence ID" value="CAG5075290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H029"/>
    <dbReference type="OrthoDB" id="8109893at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045087">
        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00107">
        <property type="entry name" value="Knot1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.10">
        <property type="entry name" value="Knottin, scorpion toxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001542">
        <property type="entry name" value="Defensin_invertebrate/fungal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003614">
        <property type="entry name" value="Knottins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036574">
        <property type="entry name" value="Scorpion_toxin-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57095">
        <property type="entry name" value="Scorpion toxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51378">
        <property type="entry name" value="INVERT_DEFENSINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0929">Antimicrobial</keyword>
    <keyword evidence="5" id="KW-0211">Defensin</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0391">Immunity</keyword>
    <keyword evidence="3" id="KW-0399">Innate immunity</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035179487" evidence="7">
        <location>
            <begin position="30"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="domain" description="Invertebrate defensins family profile" evidence="8">
        <location>
            <begin position="33"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAG5075290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="73" mass="7990" checksum="533D550A6BBB906B" modified="2022-05-25" version="1">MAKNYHTVLLLVCLSFMVIVSSPQNAVQADKLIGSCVWGAVNYTSNCNAECKRRGYKGGHCGSFANVNCWCEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H1P1</accession>
    <name>A0A8J2H1P1_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS693</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001114">
        <property type="protein sequence ID" value="CAG5073921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H1P1"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5073921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="242" mass="28376" checksum="EA2F9434811EA180" modified="2022-05-25" version="1">MPYRHSCEQRSTYKKWICWFKENIVEELNERIQAFDYGLNNRPNIPSGIKISKTSNSIGQHAAQTLCLITFLPLIIKDTILKIKQNDYVKWYMILLLIKMLKIALAPKITLEMLQDLETSTTMHHNILINHFSLSEEIKITVGKRIKFMGSELLKNKFICTTFSNNLPIFSRSVLFFSIYDELFVICESWKTIDISTSCLGYLIVNNSKTFIQKISDLPYTKNWQLYETSDKQFVIPTEYFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H516</accession>
    <name>A0A8J2H516_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS707</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001114">
        <property type="protein sequence ID" value="CAG5073935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H516"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035257580" evidence="1">
        <location>
            <begin position="24"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5073935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="304" mass="34464" checksum="B4E31241537FF48D" modified="2022-05-25" version="1">MKTENCIFLLCLHFGIIFSGGFSFSNDLTEIDDNQEFTVTTKALKELMQTSRDLSTVCAIFSICSNVTFISKLNKTIIDKKETTNSSTTKETKEICSKKEDCRHEKAECIANQCQYHSYNLDKKSYSHLNERCTDSSDCMTTRLVCQNNGCVKSNVTMERKNWCHHKLGASVCWGPERGQEYPNIECFIKNNIGIWLIREDTIHPETQPGECDFNYSIHTSLFANRFLQDDAKLVWKNSSTADLSKAVYAGMGNDQSPTLICQTVLGPIKFVGTSFPPYFHCSHFEKHGSFGSTVKFNILVHDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H536</accession>
    <name>A0A8J2H536_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Phosphorylase b kinase regulatory subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">HICCMSTLAB_LOCUS965</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. The alpha chain may bind calmodulin.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 14">Glycan biosynthesis; glycogen metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 14">Cell membrane</location>
            <topology evidence="2 14">Lipid-anchor</topology>
            <orientation evidence="2 14">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="13">Although the final Cys may be farnesylated, the terminal tripeptide is probably not removed, and the C-terminus is not methylated.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the phosphorylase b kinase regulatory chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001114">
        <property type="protein sequence ID" value="CAG5074213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H536"/>
    <dbReference type="OrthoDB" id="5971574at2759"/>
    <dbReference type="UniPathway" id="UPA00163"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005964">
        <property type="term" value="C:phosphorylase kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005977">
        <property type="term" value="P:glycogen metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.10:FF:000004">
        <property type="entry name" value="Phosphorylase b kinase regulatory subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011613">
        <property type="entry name" value="GH15-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045583">
        <property type="entry name" value="KPBA/B_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008734">
        <property type="entry name" value="PHK_A/B_su"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10749">
        <property type="entry name" value="PHOSPHORYLASE B KINASE REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10749:SF7">
        <property type="entry name" value="PHOSPHORYLASE B KINASE REGULATORY SUBUNIT ALPHA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00723">
        <property type="entry name" value="Glyco_hydro_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19292">
        <property type="entry name" value="KPBB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 14" id="KW-0112">Calmodulin-binding</keyword>
    <keyword evidence="10 14" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5 14" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 14" id="KW-0321">Glycogen metabolism</keyword>
    <keyword evidence="11 13 14" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="9 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12 13 14" id="KW-0636">Prenylation</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GH15-like" evidence="16">
        <location>
            <begin position="8"/>
            <end position="967"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphorylase b kinase regulatory subunit alpha/beta C-terminal" evidence="17">
        <location>
            <begin position="983"/>
            <end position="1148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="764"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="770"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="lipid moiety-binding region" description="S-farnesyl cysteine" evidence="13">
        <location>
            <position position="1216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR608734-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU364123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF19292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="CAG5074213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="1219" mass="137565" checksum="EB43ED9829D00154" modified="2022-05-25" version="1">MRSRSDSGVRLDYYQRVIHNVIMNHQNPVTGLFPLSEDLDHAWIRDNVYCILAVWGLSMAYKKIADVDEDRAKTYELEQSCVKLMRGLLMAMMHQKDKVEKFKITQSPLDAIHAKYSSTTGQAVVRDNEWGHLQIDAVSLYLLILAQMTASGLQIIFNLDEVAFIQNLVFYIESAYCIPDYGIWERGDKTNHGLPELNASSIGMAKAAMEAMNELDLFGARGGPTSVIHVLADEAQKCQAVLQSMLPRESNSKELDSGLLCIISYPAFAVDEPNLIQLTRDTITKKLQGKYGCKRFLRDGYRTPKEDPNRLYYEPWELRMFENIECEWPLFYCYLILDYCFQGNTGVVTDYMNSLEKILVQTEDGIKLVPELYAVAPENVEAEYAEPGSQPRLPLGRCPFKWAQSLYILGKLLQEGFLAVGELDPLNRRLCSEKKPDVVVQVVILAEDDDVREKIAQHDIHVQTIAEVAPIEVQPAKVLSHLYTYLGRNKKLGLSGRKSRDVGILSTSKLYSLQDKIFAFTPQLTDMTRFYIASDYELMIDIFKGEINFLKSSWQNMLGRPLVVMPLKNIHLGKNFDAEEFYVTNDADFLANIFTTNLAFLGINWRQMLGRPTITIVATHNHLDHGKIPLAMITTMKKLKSGYINGTRVSLGNLNDFLTTSCITNLSFLGSAEEGRPDILNPQVQKYLDEHLMRAFPHRSGLLDRPAVRSGKNLRRKMSFKGAIKKTRSIAVEPEILGMAGEDRRPSTVMPINPFIEVTDTASTSLQADAESKPEKRTPSPEIPATDDVLPRKHRIRTLTETQYADTEVEELMAMLRETESLEEQGDILQYLVDTQGLQFNTGMIENGHPVLVKDLLKGVYEKACQQKMWGIVRHTAGMLGKRVEDLAKAVTDLLVRQKQVTVGMPPTNEHTIVAPLPENELRSLIHQAYGDDESTAMLTQELLVYLAMFIRTEPQLFHEMLRLRVGLIIQVMATELSRTLICNGEEASEHLLNLSPFEMKNLLHHIMSGKEFAISSVGRGNFSIISYKSNRVSKKSQIGGFLNDQTDVNEAEPDRQGQWLRRRRLDGALNRVPRDFYPRVWQVLERCQGLAIEGKVLPQHLTQEMTSGELKFALAVETVLNTIPQPEYRQLVVEALMVLTLVTEYNVVASLGGMIVPKNQRETTPMGTLLCGGAAYICQHFYDSAPSGSFGTMTYITRAIASFLNFLPKEGDLECSIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H5A5</accession>
    <name>A0A8J2H5A5_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Similar to RTase: Probable RNA-directed DNA polymerase from transposon BS (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS1582</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001116">
        <property type="protein sequence ID" value="CAG5075428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H5A5"/>
    <dbReference type="OrthoDB" id="7555282at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5075428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="165" mass="18948" checksum="E59E949577B5547A" modified="2022-05-25" version="1" fragment="single">HYPVQRDGDPKFLYNYIEVLAILKKLKNKTSSGLDNIPTIKVIPNNQFGFKRKHAFTHAIDKLLSDINNSLHNNLIVGAVFLDQEKSFDSVWINGLIYIMVTKNFPIGLIFLIIDMIIGNFYYTWDGKLLSSDCFIIQEGLQQERVLSPIFFNIYDCDTNLAAEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H600</accession>
    <name>A0A8J2H600_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to spop-b: Speckle-type POZ protein B (Xenopus laevis)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS2519</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001117">
        <property type="protein sequence ID" value="CAG5077636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H600"/>
    <dbReference type="OrthoDB" id="7624723at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030163">
        <property type="term" value="P:protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.210.10">
        <property type="entry name" value="Apoptosis, Tumor Necrosis Factor Receptor Associated Protein 2, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002083">
        <property type="entry name" value="MATH/TRAF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008974">
        <property type="entry name" value="TRAF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24413">
        <property type="entry name" value="SPECKLE-TYPE POZ PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22486">
        <property type="entry name" value="MATH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49599">
        <property type="entry name" value="TRAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50144">
        <property type="entry name" value="MATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MATH" evidence="2">
        <location>
            <begin position="14"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="188"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5077636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="361" mass="41735" checksum="424A7D3DC246B825" modified="2022-05-25" version="1">MAVKRSITDVSKHTCHFEWRISDISSYLENFHNDLYPDKQQELRSATFTSGSAVGDKWCLRMAINYALFDDDDVLIQLEPVGEFDFGVKIKLTLFILDNEYLKKPIFDRNTVFDIRDEFNYAVLMSKNELLQNKNKLMFNDTLIIGAELTLFDITSSWLNDAMSFGPKCRRITDDYKDFLKKEQDTDTDVIIKVDDKIFKAHRAILMARCPDLFKLFPTRKDGSQVEGRITIPDMDPGTFYTILQFIHTDEVKDLDDNAENLLNAANKLKLKKLRQMCLQSLLKSLTCQSAPRLLKFAYDYNLSEILDFIANYIVSNADEVIDTPEYKTFTELNPSISYILFEKFITFKVDGSAFKNDTAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H6K2</accession>
    <name>A0A8J2H6K2_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS2907</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001117">
        <property type="protein sequence ID" value="CAG5079042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H6K2"/>
    <dbReference type="OrthoDB" id="10476255at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="61"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5079042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="161" mass="18308" checksum="911A3379A0775020" modified="2022-05-25" version="1" fragment="single">TLIVVEEVDVAEDTDLVVDLGVYSVVHHLLQPSHIFPIYNSHYHHWNHNRPSYGSSGAGQSVSSTTPTSTSTNSPVNLPVSSQNAYQQRMNQIFSMNEFNNPKKSESNTTPKTVMSTKSSFRDSTIENYLFRMKNILRIINRGKDEDLEKFLDSKINELFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H6P1</accession>
    <name>A0A8J2H6P1_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS2860</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001117">
        <property type="protein sequence ID" value="CAG5078854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H6P1"/>
    <dbReference type="OrthoDB" id="9938256at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5078854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="105" mass="12433" checksum="BBB932B7076E50D3" modified="2022-05-25" version="1">MQQNYLPPDHDDFLTPEQIKLRYQDTSLIIFKEQRNRNNNYLSFGTSRRTIEYSNFGNDPVIIKPKIINTDKDVSKSGKKIFLIKNLLKKNSASEKKKRQDATWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H6P8</accession>
    <name>A0A8J2H6P8_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Similar to chp: Chaoptin (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HICCMSTLAB_LOCUS2945</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001117">
        <property type="protein sequence ID" value="CAG5079172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H6P8"/>
    <dbReference type="OrthoDB" id="1111193at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:001164">
        <property type="entry name" value="GH01279p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000770">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025875">
        <property type="entry name" value="Leu-rich_rpt_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026906">
        <property type="entry name" value="LRR_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24366">
        <property type="entry name" value="IG(IMMUNOGLOBULIN) AND LRR(LEUCINE RICH REPEAT) DOMAINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12799">
        <property type="entry name" value="LRR_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13306">
        <property type="entry name" value="LRR_5"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00019">
        <property type="entry name" value="LEURICHRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00364">
        <property type="entry name" value="LRR_BAC"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="25"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="12"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035222822" evidence="5">
        <location>
            <begin position="22"/>
            <end position="1235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAG5079172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="1235" mass="141459" checksum="49DCA35D64F0F0F5" modified="2022-05-25" version="1">MGYIMLIITLVLMFWASMVRMHELPVQYPPCFFNPLCTCSKAVPDLGIVNCENVPMSRIPEPINSSLWELELPYNQLVQVPSKSFRHLQKLKILDLTGNQISTIAADNWRGLENTLHTLRLGKNHIDKLPADAFSGLTYLEILDLRDNSLKEIDSSVFRDGMAHLTQLYLNGNQLTSIPYSQLSTLKHMKILDLSYNRITRVIQPQMEAEIRGVQISLDTLRLDYNQIEILPPGSFQHFFRVNTTYMSGNPLMEIEDDAFRDSKIKELYFTDCELKEIDSASLRGLESSLELLDISGNNITELQQNIFQEFDFLRTLIFKDNKIATFSPVEVFTGFQYSLYNLDLSGRQNAAISLQDLRQMRNLRCLALSKLSHDSLSADDFIEFGIDVKELRITRSNLNSIKSHAFTHVRGIKYLDFSENSISSMDDEAFSEVGHSLLTLKLAHALSSSLSELPSKPFKSLTNLQYLDLSNNKIRSMSDTCFHFLKRIKRIELQDNEITEIRKGTFQGDIHSTLEEVDFAFNHITNLQTHTFVDLSVMTFLNLQDNNIDKIERRAFMNMNRLKYINLRGNKIISVVDEAFQNLPDLEFLDLAYNKMNEFDFAWFDQVGTLASFKVNASHNSISKLEINTSSFTPATSMYFNMGGTLQSNIRVLDLSHNNITDIMKYYFRPVEYALTHLYLSHNKIVNMSQAVFGNLPHLQWLDLRHNELSDIDFDCFRNTKNIQVLLLSHNNIAEIPVETLRSLKKLRILDLSYNRLRTLPDNLFTDATIESLDLSNNQFMRLPTKAITGTAAASISILDLSWNFLSSINVADSINKFRSLTFLDLSYNRLVRLDDGVFTELHHLTYLDLSNNKQLILENHGRTFFGLDDSLLTLGLSNISLLTIPELPFRHLRTLYMSNNELASIPAELASNLSSLHHLDLSHNDLTVVPLITHTLFELKSFNLAYNPITSVSNTSFLGPADSLIELDIRRLPLLTFEAGAFCKASKLQTLHITAYTTIKNFNIPNLIEYNHGLKNLLVDVQNETTLEKEMKGKFSVKLSNFTFTGRSLKDIDTDILQGMRSPHLHFGLYNTSVSKVPRKLFENARTVRNITVDLHNNDLKTLENPSNGYKPGATDKKFLMRLRMQGSAVICDCEIGWIEGWQRKHRQYQEDRCNTFPLHQYDFERDEENEYSCWDNGWDDDLRESFCANKNNMSVIQALKTDIECGWSVASTYQVSQLLVLTICILAAKNLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H730</accession>
    <name>A0A8J2H730_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Similar to sowahb: Ankyrin repeat domain-containing protein SOWAHB (Xenopus laevis)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HICCMSTLAB_LOCUS3072</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5080665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H730"/>
    <dbReference type="OrthoDB" id="60433at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058889">
        <property type="entry name" value="WHD_SOWAHA-C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14491">
        <property type="entry name" value="SOSONDOWAH, ISOFORM G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14491:SF7">
        <property type="entry name" value="SOSONDOWAH, ISOFORM G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25877">
        <property type="entry name" value="WHD_SOWAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="SOWAHA-C winged helix-turn-helix" evidence="4">
        <location>
            <begin position="7"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="98"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="205"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="109"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="123"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="135"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="221"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF25877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAG5080665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="347" mass="38805" checksum="1AFA176EE606330B" modified="2022-05-25" version="1" fragment="single">MATPSNLSLDEIRKYLIESGGSARNRDLVKHFKYFLTDPETRVEARNKFKEYVNVLATIKNEEGEKYLVLKKKYIDSVDDLVTSYPYVSSSTSLEIESPDFLTPTSPLRDPPPYRPPPPAPLSPSNSEIIPSPSHVSSTRATQDQLYSKSPTHSVFNSSTSNLNITIDGSPNYPSNQIFGSITNNSNFVASNQQSQQNISEINTDYTSPIINSPPVPPRRKSQDKFKLENKENKENISNKGKNEQEIIKEDQGPPESLGTSELPSVRERMQRFNRMASETDLHGRPNSATTPTKKRSDKGTDEDDSASVASQQLDGKAREWLVRAAQGDYQALAKLAAEEPRLTRQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H7L9</accession>
    <name>A0A8J2H7L9_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RNA-binding</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HICCMSTLAB_LOCUS3587</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5082530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H7L9"/>
    <dbReference type="OrthoDB" id="6777263at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000381">
        <property type="term" value="P:regulation of alternative mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22384">
        <property type="entry name" value="KH-I_KHDRBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045071">
        <property type="entry name" value="BBP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055256">
        <property type="entry name" value="KH_1_KHDC4/BBP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11208:SF140">
        <property type="entry name" value="GH05812P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11208">
        <property type="entry name" value="RNA-BINDING PROTEIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22675">
        <property type="entry name" value="KH-I_KHDC4-BBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="K Homology" evidence="3">
        <location>
            <begin position="69"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="192"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="214"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG5082530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="362" mass="39216" checksum="0C23246A03EA023A" modified="2022-05-25" version="1">MYHSYILRSFCIYRNHTRSFSDSSCGAGRNAAGGAGGSSGSGGVRGVTAGGNCDGVERRMVDITRDKPIKVAVRVQVPVRDHPKFNFVGKLLGPKGNSLKRLQEECGCKMAVLGRGSVKDRQKEEELRASGDPKFSHLSEDLHVEISAFATPAEAHARIAYALVEVRRFLVPDYNDDIRQEQMWEMQMMNNTENNPQDLLSSPEDTLSEPAASPVSSTTNGNGTTIDQESSSKLGVTQMSQANGLLIGCRKRPLISSGNRPAMSPIKRTVMSLLARARAAQHKELHQQVGMVSNQTSAALHQSQLNLLAAPAVHTVAQVPQLHLIGSSIPQHTAPRRPPILPAPLPQHQMLGPTIHGVIHTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H7Z3</accession>
    <name>A0A8J2H7Z3_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS3603</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5082590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H7Z3"/>
    <dbReference type="OrthoDB" id="7608910at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="68"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5082590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="88" mass="9612" checksum="03FFDC629CF56288" modified="2022-05-25" version="1" fragment="single">GLVAMDSLSESDNKNTEEDTGESDPEERRERMEPIRTSTKNALITTHQNLSDIYPHRVKVSIVGAGKIGVACAIAILMRVTVILIGFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H8C0</accession>
    <name>A0A8J2H8C0_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS3962</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5083897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H8C0"/>
    <dbReference type="OrthoDB" id="7554998at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="315"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="149"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="162"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="236"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="258"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="334"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5083897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="379" mass="38507" checksum="A74EBC349092E123" modified="2022-05-25" version="1">MESGPPARGGFRGRGGPMRGRGGFGERGRGGPPRGGMMRGRGGAPGPMRGGPPGMRGRGGPPGRGGRGGHYPPGGPPDTSLAGPGGAPPPPPGVGGPTRGSGRGAPGGFRGRGRGDFGRGDSRGGGFRGRGGDRRGRGSGMFNRDGPPRGSGRGSNGSGFGDRGRGMDRGRGAPVKRGGVPGAGGPPKRPRYDVTAAQPANGYASQPPSQGYGPGNGYGQAAPAPVGSYGATTGTYGPPQSGYQQSYQGYESYPTPADYTQSTTFYQQGYPAQVPPDNRYGGIPPAPAASFNSSDPYGYGKVPPQVNYQQEAVAPAVGGGGDGVGNYPPANPYDDQSCNNSGMTVRGDYSTHEYDYTSQDGGYGKQDYGEYQSVDRHFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H8R8</accession>
    <name>A0A8J2H8R8_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS3234</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5081269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H8R8"/>
    <dbReference type="OrthoDB" id="6429739at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5081269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="237" mass="26414" checksum="EBE6403F1252764D" modified="2022-05-25" version="1">MKIPHLVYFAICFQPGHENPAQIRGKRNDLTQPRPSRCVVKANNYSVLGIVVVCHNNSTSTPVRFLNKRPTSLYLVTCIPLALHGIVDVIDRLMSFFKGLVLFSWGKFDKRRPTDPKEMQRCPYLHEMKERLLSQPTPTDSLDMERLDGGTPVKEANLHTEYPAQTNPGVIPDPPEMPPDTLIGTVVKLNSDGYGSHTSPAHARQPLVPQGSMNPPLCLTPTHSSYGRNFPKNANVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H8S3</accession>
    <name>A0A8J2H8S3_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Protein phosphatase</fullName>
            <ecNumber evidence="11">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HICCMSTLAB_LOCUS4455</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the PP2C family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="11"/>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5087230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H8S3"/>
    <dbReference type="OrthoDB" id="60843at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.40.10:FF:000009">
        <property type="entry name" value="Blast:Protein phosphatase PTC7 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039123">
        <property type="entry name" value="PPTC7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12320">
        <property type="entry name" value="PROTEIN PHOSPHATASE 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12320:SF1">
        <property type="entry name" value="PROTEIN PHOSPHATASE PTC7 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07228">
        <property type="entry name" value="SpoIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8 11" id="KW-0464">Manganese</keyword>
    <keyword evidence="4 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 11" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="12">
        <location>
            <begin position="42"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU366020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAG5087230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="287" mass="31162" checksum="2EBC581B3BF7866D" modified="2022-05-25" version="1">MQSIYWTGRLLSRALWNGISSYTTCADPAVVKKREASLVSAVCGFPKDLSRGRIRKGQFGVADGVGGWRHYGIDPGEFSSYLMKTCERLVSLGKFVPHEPAGLLAKSYYELLENKQSILGSSTACVIVLNKETSSIYAANIGDSGFVIVRKGKVVHRSSEQQHYFNTPFQLSLPPPGHSDLVLRDSPESADTSTFGVEDGDVILLATDGVFDNVPDQLLVTEMRKVEGERDPTKIQGVANTIAWMARSLAFDGNFLSPFAQSARQNGIEAIGGKPDDITVLLATIAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H912</accession>
    <name>A0A8J2H912_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Similar to GGPS1: Geranylgeranyl pyrophosphate synthase (Homo sapiens)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HICCMSTLAB_LOCUS4609</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the FPP/GGPP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5087792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H912"/>
    <dbReference type="OrthoDB" id="6921389at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120531">
        <property type="term" value="F:prenyl diphosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042811">
        <property type="term" value="P:pheromone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00685">
        <property type="entry name" value="Trans_IPPS_HT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.600.10:FF:000009">
        <property type="entry name" value="Geranylgeranyl pyrophosphate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000092">
        <property type="entry name" value="Polyprenyl_synt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033749">
        <property type="entry name" value="Polyprenyl_synt_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12001">
        <property type="entry name" value="GERANYLGERANYL PYROPHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12001:SF44">
        <property type="entry name" value="GERANYLGERANYL PYROPHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00348">
        <property type="entry name" value="polyprenyl_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00005">
        <property type="entry name" value="Isoprenoid_Synthase_Type_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00723">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00444">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAG5087792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="322" mass="36978" checksum="3F6B2A2111C2154D" modified="2022-05-25" version="1">MSSEINSIPYSKSGDKDQDEKLLQPFTYILQVPGKQIRAKLAHAMNCWLKIPAEKLQAVGDIVQILHNSSLLLDDIQDNSILRRGIPVAHSIFGVPSTINAANYAIFIALERVLALDHPEATKVYTEQLLELHRGQGIEIYWRDNYICPTEAEYRHMTMRKTGGLFNLAIRLMQLFSECKEDFSMLTGILGLYFQIRDDYCNLSMREYSDNKSFCEDLSEGKFSFPIIHAIQTYPEDRQVLNILRKRTTDIEVKKYCVTLLEKFGSFAYTRTVLEDLDKKARDEVERLGGNPLFIEFLNKLSCWPKNPMSLDVEMNDLSASD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H9F1</accession>
    <name>A0A8J2H9F1_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Similar to Smarcc2: SWI/SNF complex subunit SMARCC2 (Mus musculus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HICCMSTLAB_LOCUS4780</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the SMARCC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5088263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H9F1"/>
    <dbReference type="OrthoDB" id="118550at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016514">
        <property type="term" value="C:SWI/SNF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048858">
        <property type="term" value="P:cell projection morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000020">
        <property type="entry name" value="SWI/SNF complex subunit SMARCC2 isoform c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000014">
        <property type="entry name" value="SWI/SNF complex subunit SMARCC2 isoform C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049898">
        <property type="entry name" value="MARR_BRCT_CHROMO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017884">
        <property type="entry name" value="SANT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032451">
        <property type="entry name" value="SMARCC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032450">
        <property type="entry name" value="SMARCC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007526">
        <property type="entry name" value="SWIRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032448">
        <property type="entry name" value="SWIRM-assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15381:SF1">
        <property type="entry name" value="CHONDROITIN SULFATE PROTEOGLYCAN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15381">
        <property type="entry name" value="CHONDROITIN SULFATE PROTEOGLYCAN 5 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00249">
        <property type="entry name" value="Myb_DNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04433">
        <property type="entry name" value="SWIRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16495">
        <property type="entry name" value="SWIRM-assoc_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16496">
        <property type="entry name" value="SWIRM-assoc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16498">
        <property type="entry name" value="SWIRM-assoc_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52032">
        <property type="entry name" value="MARR_BRCT_CHROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51293">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50934">
        <property type="entry name" value="SWIRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Chromo" evidence="11">
        <location>
            <begin position="2"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="domain" description="SWIRM" evidence="9">
        <location>
            <begin position="443"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="domain" description="SANT" evidence="10">
        <location>
            <begin position="623"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="8">
        <location>
            <begin position="628"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="280"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="756"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="963"/>
            <end position="1052"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="413"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="780"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="799"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="821"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="963"/>
            <end position="994"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="995"/>
            <end position="1032"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1036"/>
            <end position="1047"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS52032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAG5088263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="1065" mass="118424" checksum="202B89F3723157AD" modified="2022-05-25" version="1">MLTLQPKKDGGPNAKFFESAEVLAQLDGVKQWLLKNCKKYVTTDPPTNKSLSTLIIQLIQFQEDNLGKNVSKPPMARLPMKCFLDFKPNGGLCHIFATAYKFKQEQGWRRFDFPSTSRLDRIIEMLMAIERSLIQNRCITVPCVYIRPEIDKATASKVKENIRRHQGTIAENEAEATHIIYPPVDPLEEEYARPCLRRDRSVLLHWYYFPDSYDSWVNFDLPFDIPEGGFGGPSPKSTYKVSATWALDLDQYNEWMNEEDYEVDDNGQKRIHKYRLSVEDMMAPPSAPPPASAKKQKRKRSPSPPPKIGKRKSGRGPAGLAGTSAVATPKKTRGGVDEEEDLTQGMEDPPAEPRIVEVMSNPTNAPLSGSGGGSTGSLTSNKKQDNELQPLKSGNMADLDEPIESEKGSQGTQDREERDTSKERGDNGKDEPEDNVTEQTHHIVVPSYSAWFDYNSIHTIEKRALSEFFNGKNKSKTPEIYLAYRNFMIDTYRLNPTEYITSTACRRNLAGDVCAIMRVHAFLEQWGLINYQVDAESRPTPMGPPPTSHFHVLSDTPSGLAPVNPNPPKTQQPSAAKTLLDLEKKPVVSVEEKGAVGAMANFGLKIDQYARKPAVLKNKQAAGATRDWTEQETLLLLEGLELHKDDWNKVCEHVSSRTQDECILHFLRLPIEDPYLEEGGPEGLGPLAYQPVPFSKAGNPVMSTVAFLASVVDPRVAASAAKAAMEEFAAIKDQVPAALLDQHLKNVQASANADGKFDPAAGLAQSGIAGTGPPEPPEDASASSTPGATATSPSAATSEGKKDESIEKREGDESIPAPIVPKKEETTDTERSDQPEKMDIDVKESDADAKKINDNPEEIEAKEKKDKVVRDAQLQSAAAAALAAAAVKAKHLAAVEERKIKSLVALLVETQMKKLEIKLRHFEELETTMEREREGLEYQRQQLITERQQFHLEQLKAAEFRARQQAHQRIAQEQQQQQQQQQQGQQHPAWQPGTQPQPPQQQQPPQPQPPPQPQQQQPPSPQAQPQPPPHTPPQQVINKNHYSSQVTEESRDCWGFNVFKASIKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H9Z5</accession>
    <name>A0A8J2H9Z5_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Gustatory receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HICCMSTLAB_LOCUS3675</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Cell membrane</location>
            <topology evidence="1 8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the insect chemoreceptor superfamily. Gustatory receptor (GR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5082883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H9Z5"/>
    <dbReference type="OrthoDB" id="6366728at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030425">
        <property type="term" value="C:dendrite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043025">
        <property type="term" value="C:neuronal cell body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007635">
        <property type="term" value="P:chemosensory behavior"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008049">
        <property type="term" value="P:male courtship behavior"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050909">
        <property type="term" value="P:sensory perception of taste"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013604">
        <property type="entry name" value="7TM_chemorcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21143:SF104">
        <property type="entry name" value="GUSTATORY RECEPTOR 8A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21143">
        <property type="entry name" value="INVERTEBRATE GUSTATORY RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08395">
        <property type="entry name" value="7tm_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 8 9" id="KW-0675">Receptor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="26"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="68"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="109"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="159"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="187"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="272"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="309"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="381"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAG5082883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="408" mass="47324" checksum="20EA8330ED1F5364" modified="2022-05-25" version="1" fragment="single">MSKKFFHKRKAAIKKINIFSLERQHIVYYCILNFFKMLGLAPLKVNFSKIFKNIKNNNVYLYEISKCVFLYNSFLVFAFCVYITLVFIYDLWFDDYNNSIASFFFDRSATLFGVIGSIFIWLYYIVHKSAIIDIVNELYSIDNYLKSTGNFYFLAKNHYLYSVFIGNFIMNGCIIFVQIIFYPPISMLAWAVPCAISSWVLIQYSLVIYIIFQRCKCVNKTILRISDISTQFETIALSITKIPICKSVIVDITNIQYINIKVCKLCGKVVDFYAFPVLIAVVYFMTVAVVNLYYTMVSLNLINYREVSLLPYIDCGLTSVLTIFNFVILTTNVTKITREINNTAAYIHLLLDRCTMSLEVKKSLLEFSANLLYRNIEFGSYGIIVLDGFLLQSIFGTIVTYLIILIQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HAV2</accession>
    <name>A0A8J2HAV2_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Similar to sdk: Protein sidekick (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HICCMSTLAB_LOCUS5392</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5089833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HAV2"/>
    <dbReference type="OrthoDB" id="6266590at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013151">
        <property type="entry name" value="Immunoglobulin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050964">
        <property type="entry name" value="Striated_Muscle_Regulatory"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13817:SF166">
        <property type="entry name" value="NEURONAL IGCAM-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13817">
        <property type="entry name" value="TITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00047">
        <property type="entry name" value="ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035186965" evidence="3">
        <location>
            <begin position="23"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="236"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="4">
        <location>
            <begin position="15"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="5">
        <location>
            <begin position="114"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAG5089833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="324" mass="36562" checksum="2BF7DBA4B7D07B04" modified="2022-05-25" version="1">MIKHGIILLLLLVLPGWQEALGSVSVRTVEVDIGQNLTIACTDENVSRHPGNYTNVMWVREGRKDGQVRRMKIGSNKALELVNVSLDDAGNYFCTLDNDANAVKTRINIQVKTPPPALHNVWVKPSTILANILWEVAGTGGYPIIDFTAEYRLKPGVGEEPEDWKPIMPTHIPPNSRQIDVYHLEPNTTYLFRVWATNKLGRGDIVEVEGHTHHTIEELELAKHLLAGVENFDTRIWVAAVGIVMGTLMVLGLGTCYLLYRECKAPSQLEDQEVIELVPNIILNPGFFDERSERQHQQQHQDENFNNQTTTRLNNNSVILPRRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HBR3</accession>
    <name>A0A8J2HBR3_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Similar to SUDS3: Sin3 histone deacetylase corepressor complex component SDS3 (Bos taurus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HICCMSTLAB_LOCUS5146</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5089213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HBR3"/>
    <dbReference type="OrthoDB" id="70376at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013907">
        <property type="entry name" value="Sds3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21964">
        <property type="entry name" value="BREAST CANCER METASTASIS-SUPPRESSOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08598">
        <property type="entry name" value="Sds3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01401">
        <property type="entry name" value="Sds3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="176"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="121"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="24"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="35"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="50"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="180"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG5089213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="328" mass="38317" checksum="24E3332B67B26BB9" modified="2022-05-25" version="1">MSYQGSPFSVVYGPDDYDLDDDNEHYMDDDRNVDDPDESDEDTEEASEPEMGKSEEMTEIKEQVYQDKLGSLKKQLQQLNDGSHPEFIRKLKRLESQYQERIRLNIIHREYLIEWAERDYVAEKKAACKEFEDKKIDLKENLLTDMEEKKKMIESDRQTMELTGDSTEVKPVMTRKLRRRPNDPVPEKVEKRRKPPPAQLNYLLDEKEIENDLKAISRGKVTPTVRKQVVIPHFNNPVNISTSHVPPSTEANLVETRIEDGKLWYERRWYHRGQPVYVEGMEMSRFGANIAAIGTEVIWVKKVSDGTKVRICISQLSRGRVSLKRRAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HBU4</accession>
    <name>A0A8J2HBU4_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS4424</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5087119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HBU4"/>
    <dbReference type="OrthoDB" id="10051804at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33964:SF1">
        <property type="entry name" value="RE45066P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33964">
        <property type="entry name" value="RE45066P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035211349" evidence="1">
        <location>
            <begin position="20"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5087119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="151" mass="17137" checksum="558318EECA95CF78" modified="2022-05-25" version="1">MFLIYFLSIIVTVLASCRGHECGQENLLKCARPLGKITNNNNLGFVTTKSELQALCPDLQSSMKCINSYTKNCMPENQRQNFNSLYQGVNIAIKELCQDGSYQDAFLKHAPCMQKVQTDYELCSKRYQQSVIELESKNTTKSSENVKSVCW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HC60</accession>
    <name>A0A8J2HC60_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similar to Tmem177: Transmembrane protein 177 (Rattus norvegicus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS6463</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5092944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HC60"/>
    <dbReference type="OrthoDB" id="110174at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026620">
        <property type="entry name" value="TMEM177"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21824">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 177"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21824:SF4">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 177"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="17"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="171"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="205"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5092944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="316" mass="36688" checksum="FBE938071B242B77" modified="2022-05-25" version="1">MRKETSVSWFVTPKGRMFMMGTAGFTTVALFGLQFVPHTMGLNKYFDIVTMRRLGNPIPLTSNLEKLWNQVLSDIKISDYHREILRPFMVFGYDSWHAGSLYSRFGALIGIPTNFVYEKVSSIDKDSIVVNDDPVDWTRKDAKELLNALILSDEAKKYAVAREIMMVNNRFIYYEAAANGILSFACYHSASKWNETRGLLEKPFGIRAFFYVCFAAFYWGIWAMQRDALTRHYEFAADKKLSELGPEYVRGGLEFYDKTLQRNTALRSLLGERGNKLYTAMGNDHSFFRQKHLPYTQRKYFFEDIVKQFHNSADKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HCC3</accession>
    <name>A0A8J2HCC3_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ubiquitin-protein ligase E3B</fullName>
            <ecNumber evidence="3">2.3.2.26</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">HECT-type ubiquitin transferase E3B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HICCMSTLAB_LOCUS5312</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 14">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.26"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Postsynaptic density</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.26" evidence="3"/>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5089635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HCC3"/>
    <dbReference type="OrthoDB" id="8068875at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0014069">
        <property type="term" value="C:postsynaptic density"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009966">
        <property type="term" value="P:regulation of signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00078">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2160.10:FF:000002">
        <property type="entry name" value="Putative Ubiquitin-protein ligase E3C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2410.10:FF:000012">
        <property type="entry name" value="Ubiquitin-protein ligase E3B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2160.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2410.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044611">
        <property type="entry name" value="E3A/B/C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000569">
        <property type="entry name" value="HECT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035983">
        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000048">
        <property type="entry name" value="IQ_motif_EF-hand-BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45700:SF3">
        <property type="entry name" value="UBIQUITIN-PROTEIN LIGASE E3B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45700">
        <property type="entry name" value="UBIQUITIN-PROTEIN LIGASE E3C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00632">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00612">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00119">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00015">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56204">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50237">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="12" id="KW-0436">Ligase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0770">Synapse</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 10" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="HECT" evidence="11">
        <location>
            <begin position="669"/>
            <end position="1034"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="10">
        <location>
            <position position="1002"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00034105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00067505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00077267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAG5089635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="1034" mass="117628" checksum="8BB3ECE10992336B" modified="2022-05-25" version="1">MFRAEESAKGNFLQQTKAAREERANEKRKEAAVVCIQACVRGWLARNKFATRILNEFDTYFPNETATDTSIELKPALQPKLSYVGVALNKDHYISWISQMKMILYQCMIGLDELRPERPTDHRCILLRLHTLVSFTSAGTWAIQKVKGMEKLRAGMNQLCANIMGHLVNSGFYTIMQTLLVKGLGREKIALKPLALSAAVTLTMRPLISSQMSDKLVSLFLINIFSVPALVYHLNIYSTECINLFISHNLFTRSLELLNSEQNLRIIFNALEGSYALCLLANLIQLANIERDEVLKDLYFPSFIFVVTKMLESCQQYVVAKQSNLTHWHPVLGCFAQAVDSSLHGAITYTKIQLAHLWTGKIVSQLIGLPLVEIVEKEVPSPPEHQSTSVGTNIFRRAFLEARTNRNNSNKNYRKLGSPETTKISLICSLYQTALHTLTQMKLDILTGLCYQDKVLYHMWLFLNTLGPHCGLRAFLDHLAANTKCSAPEFQMLILFSDCMTHYVTILDDMEMYEQQDPFKLTDFVTMSYFLNQFLYKAVLNNLFDVTDVKTVSNNPLFTSLHTLLMAIYRRDCRRTFCPEGHWLAKEVRVSGFLADLEKGRRGAALLLSKMPHVIPHSERVVLFRKHVADEKAVLGLTESACNSPSSTLISVHRTRIVEDGYRQLAMLPPQALKGVIRVRFVNEQGLDEAGIDQDGVFKEFLEETIKRVFDPSLNLFKATSENRLYPSPTSYMQENHLQLFEFVGRMLGKAVYEGIVVDVPFASFFVSQFSGQAGGALYSWLDELASLDRDLYRSLTLVKHYKGDVSELELTFSLDEDVMGQLVTHELNPGGKAETVTNSNKINYIHHMAHFRMHRQIKDQTAAFTKGFKSIINPDWLSLFSTPELQRLISGDNVPLDLRDLRRHTQYYGGFHDSHRVVCWLWDILEKDFSEEERGLFLKFVTSCSKSPLLGFAHLEPPFSIRCVEVGDDEDTGDTIGSVIRGFFTIRKKDPQNRLPTSSTCFNLLKLPNYQKKSTLREKLRYAVTSNTGFELS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HCX0</accession>
    <name>A0A8J2HCX0_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to slim: Kelch domain-containing protein 10 homolog (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS5523</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5090187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HCX0"/>
    <dbReference type="OrthoDB" id="7676067at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032874">
        <property type="term" value="P:positive regulation of stress-activated MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011043">
        <property type="entry name" value="Gal_Oxase/kelch_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052125">
        <property type="entry name" value="KLHDC10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46428">
        <property type="entry name" value="KELCH DOMAIN-CONTAINING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46428:SF1">
        <property type="entry name" value="KELCH DOMAIN-CONTAINING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50965">
        <property type="entry name" value="Galactose oxidase, central domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5090187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="277" mass="32306" checksum="C13F30929BBC36EA" modified="2022-05-25" version="1">MINQPLQGEQVPKYPLSNNMIRDGGYYYLVGDVDDENNHVGDVYRINMKSGIWECVYKCQGKDKKNELWTNIPYYLVFDGKKIFTFFSFEDEGYDDDFTPYSFLKLAAFDVENRRWRTINTYGDVDHVPNYPMDRGGLDGAFFQMTHYQDSNNDLIVILSGKFDHKDNYNDLWKLNLSTMTWKNIDNRGSLIPRTFKRFSMTVSPAGQLFTFGGFIGDPKERVPCSSRVHSVWITIPKLSDICWESILHYLPGLVSMSQEQVGPKSWYFMEIFPIEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HD02</accession>
    <name>A0A8J2HD02_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS5584</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5090322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HD02"/>
    <dbReference type="OrthoDB" id="7701443at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="109"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="162"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5090322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="296" mass="33496" checksum="0FE94703F16153EF" modified="2022-05-25" version="1">MFALIWWIHSKKSSVIPYNTIKFSAKKEASVLQRKKFHSVKILRTSEDNAWLESLKVDGDGNVYMPEDNIHKKNLRARKRESSKEGKELTSEIKKRKLQRDLKLAKEPSIFEEIDKPPAGKTRDATSREEESKNTDSSSEESQLYIGFLQGVVGFLKDHGCSSSSSSKTVVETKDSPASRSSASGYSKMPWNLSGPRKVELHPMSDVYIESCELDCLKTKYTYDPKEMSRQIFKKVIGTDNLLKMSRTGGNGWTRLPNDVFTAVHGFISKNARPKLSAAEFERCVTLMFTSLRPGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HD38</accession>
    <name>A0A8J2HD38_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS7662</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5095344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HD38"/>
    <dbReference type="OrthoDB" id="10321968at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5095344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="182" mass="21655" checksum="7D80844EF9AE58F8" modified="2022-05-25" version="1">MAESCNCTSDCISKTSVPLTNLRLIITSLFIRYPSLRENELAISDYVIEVAKGVTEKRFMELKFQWLKAKYSATCFRFFFYNSLKYVDNCKMAQALLRECIKMKKFKEYVAFRERHSKMIEKFLSIGMTTRDWEELLEAKKQELLAFKLEYSDFLTEREKCLAESIQNDKELIRLRELIIEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HD89</accession>
    <name>A0A8J2HD89_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Similar to Cfap410: Cilia- and flagella-associated protein 410 (Mus musculus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HICCMSTLAB_LOCUS6402</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5092851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HD89"/>
    <dbReference type="OrthoDB" id="1517790at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097733">
        <property type="term" value="C:photoreceptor cell cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007010">
        <property type="term" value="P:cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000094">
        <property type="entry name" value="protein C21orf2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003603">
        <property type="entry name" value="U2A'_phosphoprotein32A_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18849:SF0">
        <property type="entry name" value="CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 410-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18849">
        <property type="entry name" value="LEUCINE RICH REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14580">
        <property type="entry name" value="LRR_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00446">
        <property type="entry name" value="LRRcap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0966">Cell projection</keyword>
    <keyword evidence="5" id="KW-0969">Cilium</keyword>
    <keyword evidence="5" id="KW-0282">Flagellum</keyword>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="U2A'/phosphoprotein 32 family A C-terminal" evidence="4">
        <location>
            <begin position="103"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="170"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="234"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="183"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="203"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="242"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="256"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAG5092851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="371" mass="42959" checksum="5E8C48DC89CE0CF7" modified="2022-05-25" version="1">MVRLTEEMVVARSRISDLTAVKKLNCWGSELTDVSILRELKKVEVLSLSVNKINSLADFQYCSNLKDLFVRRNNITDLNEICYLQNLPNLRNLWLEENPCAEREGYRMSVIRALPNLEKLDDKFVTADEINVALSRGKILVHPLSMDASPPQSDPASPEEVAEFIDEVELERNRRYSSSSDQRSYDDPHQGHEEYQDTDRRNANYNASSPHQYSQNNHYSYDLQNGQTKNQIKDEAAKSVESRTNGHSLQTNIPEVSKDYDDRPAVARQNGDYEDRRGYSTEYERSSEPSTHRSQQVLPSPRTAYSEDPREMPGWVRHAEKEKCRFHYHRRPVTRNSNILSAVLCLVKELDYPSLEVVEMAVRNRMDELEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HDJ0</accession>
    <name>A0A8J2HDJ0_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Similar to pdcd10: Programmed cell death protein 10 (Xenopus tropicalis)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HICCMSTLAB_LOCUS7642</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the PDCD10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5095304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HDJ0"/>
    <dbReference type="OrthoDB" id="6017654at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090443">
        <property type="term" value="C:FAR/SIN/STRIPAK complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903358">
        <property type="term" value="P:regulation of Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.330">
        <property type="entry name" value="Nucleotidyltransferases domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046409">
        <property type="entry name" value="PDC10_dimerisation_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009652">
        <property type="entry name" value="PDCD10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048288">
        <property type="entry name" value="PDCD10_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13250:SF1">
        <property type="entry name" value="PROGRAMMED CELL DEATH PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13250">
        <property type="entry name" value="TF-1 CELL APOPTOSIS RELATED PROTEIN-15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06840">
        <property type="entry name" value="PDC10_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20929">
        <property type="entry name" value="PDCD10_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0037">Angiogenesis</keyword>
    <keyword evidence="8" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Programmed cell death protein 10 dimerisation" evidence="11">
        <location>
            <begin position="8"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF20929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAG5095304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="210" mass="23439" checksum="AAF20DA364E3C655" modified="2022-05-25" version="1">MTMGDDTPVTSLVLPVILRPILSKLEAQNITAAQTLRSALSKAESNHPGITYDLVVGIVRRADLSLDMNASVLRLQGVASDCDAIEYRSARSEDAFQELNRKSTALKRILSRIPDEITDRKTFLETIKEIASAIKKLLDAVNEVTAFIPGTAGKQALDQRKREFVKYSKRFSNTLKEYFKEGQAKAVFISALFLIRQTNMIMVTVKNKCE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HDU1</accession>
    <name>A0A8J2HDU1_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Tetraspanin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HICCMSTLAB_LOCUS7807</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Membrane</location>
            <topology evidence="1 7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the tetraspanin (TM4SF) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5095635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HDU1"/>
    <dbReference type="OrthoDB" id="9972904at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1450.10">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018499">
        <property type="entry name" value="Tetraspanin/Peripherin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000301">
        <property type="entry name" value="Tetraspanin_animals"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008952">
        <property type="entry name" value="Tetraspanin_EC2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19282">
        <property type="entry name" value="TETRASPANIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19282:SF252">
        <property type="entry name" value="TETRASPANIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00335">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002419">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00259">
        <property type="entry name" value="TMFOUR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48652">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="58"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="87"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="203"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="149"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="150"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR002419-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG5095635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="240" mass="25715" checksum="E8D56DD38CBC4E8C" modified="2022-05-25" version="1">MGKRFETIAATACMTTLLMLFNFVFWCTGIAMLCVGILMRIQLRDYVDMSVEGSGAALLGLACLGGLVVLAATLACCCTARGHPALLYLYGGFLAVVALLELGAGASVYAYRTTLTEGFDQGLNDSMALYGIDKAKSAHIDVMQSTLHCCGNRAYTDWSEMKPPKKIPQTCCKSRDKCAIDNINDIYDEGCYDLVIDFINSNIGLVAGSAVGVAFFPLIGVFLACCLASNINKAKYEQVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HDV6</accession>
    <name>A0A8J2HDV6_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">nicotinamidase</fullName>
            <ecNumber evidence="7">3.5.1.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Nicotinamide deamidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HICCMSTLAB_LOCUS7756</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="pathway">
        <text evidence="6">Cofactor biosynthesis; nicotinate biosynthesis; nicotinate from nicotinamide: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the isochorismatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.19" evidence="7"/>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5095533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HDV6"/>
    <dbReference type="OrthoDB" id="167809at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008936">
        <property type="term" value="F:nicotinamidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019363">
        <property type="term" value="P:pyridine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.850">
        <property type="entry name" value="Isochorismatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000868">
        <property type="entry name" value="Isochorismatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036380">
        <property type="entry name" value="Isochorismatase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052347">
        <property type="entry name" value="Isochorismatase_Nicotinamidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11080:SF2">
        <property type="entry name" value="LD05707P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11080">
        <property type="entry name" value="PYRAZINAMIDASE/NICOTINAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00857">
        <property type="entry name" value="Isochorismatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52499">
        <property type="entry name" value="Isochorismatase-like hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF-hand" evidence="9">
        <location>
            <begin position="5"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="9">
        <location>
            <begin position="52"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00039017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00043224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAG5095533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="299" mass="33917" checksum="D1E1366AB9AC1E85" modified="2022-05-25" version="1">MADSLVNLDMDACFSAFDRDADGFLSIEEFELICRALFRNDRGKIYGVEDYQLREIFDIFDTKKDGVIDRDEFEVCWNRWIKICTRPRSAFLIVDVQNDFITGSLNIKHCAAQQDGSEVIEPINLYDTVTFKGPLGLKQRLWPRHCVQDSWGAELHKDLKIVDKAIKIYKGTNPEVDSYSVFWDNKKLTTTTLSSQLQDKGATDIYICGLAYDVCVGATAVDALTSGYRTILIDDCSRGVDLVDIEKTKSMVIASNGVIVNSSQVKAMVEGRDRRPELGYKLALEIKQFFKETINDKEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HE95</accession>
    <name>A0A8J2HE95_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similar to Cc_odve66_1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS6085</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5092359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HE95"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.100">
        <property type="entry name" value="Chondroitin AC/alginate lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008929">
        <property type="entry name" value="Chondroitin_lyas"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5092359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="687" mass="79249" checksum="E3E825067608F68C" modified="2022-05-25" version="1">MIFIIISIIIVFVVGTLVTVQVIVPALTEDSKPVPKEQEQLPTPEARTSTEPQPLTQHSSGPQLTIQKPISKLSNSDNLENQLLAEMQGDAPQAESQVLTEVQHSVEPKETVLSRLQLSLKNIYNMPSEYQAIADQYIKNMDQVYQDTFTLEDHPNMDKITSFGIALLHQYANDSKQTYLPIVEHLISKINEQLPQGNELVHLPTKWNQKYYFFCVRLTRMLAMFEILSTNESIKTICHQRIYQITPFLWKSLEWDHLMGIQNAWIAIPRLITNFLKETKTYEKETQPNHIGTLKQIMKVEFLKNIDAINLDGIWIEKSCIFNGVATYWPLVESGTFYASVFRALGFEADIDDVTQKILDKILHPSMDIIPLGLFGRQSDIRITKTLKTNWSNYQRKAGLDIGIFPVAGLGVFKSKDFAFWVRVQRWYIAGYEADQVDFELAGGWIQMRKLYLKSIEQSYESMTWQKIKMQPGVISNEDGSDDFEYMKPQKEEKANYPMDVISHVGTLMDEGRRVLYWKNEYKFKSLFGMSKITEFGVCTDNGLVMQMEVLNKTDKILKIRIKDDDAHGMEFDCRCSDSNQKCNNGFVTVGKNDSIVVNWRQVFKKEEDDHPQEVTRTTKGHMTFKFGGDDYVIESRDKLHFVIKNSQVLLAGSFEKSLSYIIEYGYKNRAIKFEFNPNTLMYKAII</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HEC4</accession>
    <name>A0A8J2HEC4_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Similar to SUN2: SUN domain-containing protein 2 (Homo sapiens)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HICCMSTLAB_LOCUS6737</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5093301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HEC4"/>
    <dbReference type="OrthoDB" id="342281at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034993">
        <property type="term" value="C:meiotic nuclear membrane microtubule tethering complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043495">
        <property type="term" value="F:protein-membrane adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045119">
        <property type="entry name" value="SUN1-5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012919">
        <property type="entry name" value="SUN_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12911:SF8">
        <property type="entry name" value="KLAROID PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12911">
        <property type="entry name" value="SAD1/UNC-84-LIKE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07738">
        <property type="entry name" value="Sad1_UNC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51469">
        <property type="entry name" value="SUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="SUN" evidence="5">
        <location>
            <begin position="1"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAG5093301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="124" mass="13955" checksum="65CB311ABF22AFDA" modified="2022-05-25" version="1" fragment="single">NNVAPGQCWAFKGSSGCITIKLLSPIYVTSITLEHITVHESPNSKTTSAPRCFSVWGLKSINDKEGYFFGKFMYDNCASPIQNFPMKKKSNESYEIIELKIHSNSGNPNYTCLYRVRVHGELDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HEK5</accession>
    <name>A0A8J2HEK5_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">phospholipase A1</fullName>
            <ecNumber evidence="4">3.1.1.32</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HICCMSTLAB_LOCUS6564</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 2-acyl-sn-glycero-3-phosphocholine + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18689"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="ChEBI" id="CHEBI:57643"/>
            <dbReference type="ChEBI" id="CHEBI:57875"/>
            <dbReference type="EC" id="3.1.1.32"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the AB hydrolase superfamily. Lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.32" evidence="4"/>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5093063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HEK5"/>
    <dbReference type="SMR" id="A0A8J2HEK5"/>
    <dbReference type="OrthoDB" id="8183961at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008970">
        <property type="term" value="F:phospholipase A1 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017171">
        <property type="term" value="F:serine hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013818">
        <property type="entry name" value="Lipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000734">
        <property type="entry name" value="TAG_lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11610">
        <property type="entry name" value="LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11610:SF151">
        <property type="entry name" value="PHOSPHOLIPASE A1 MEMBER A-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00151">
        <property type="entry name" value="Lipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035321546" description="phospholipase A1" evidence="9">
        <location>
            <begin position="22"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="Lipase" evidence="10">
        <location>
            <begin position="25"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAG5093063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="301" mass="33930" checksum="F8D90D4F1515B326" modified="2022-05-25" version="1">MSLKTITCYFLILVIVVICDANYEDNIHFKLFTRKQQSDSKTIVISKEYNNILQIGFDVTKSTKVIVHGFKSSSNFFALVRIKNNYLSKYDCNVIMVDWSHYAEGEYVSTIGRSRIIAVYVARLFLVLIKHGVQDIHAIGFSLGAHIPAVATTYLGNNKLKRITGLDPAKPFLMNVGLDAKLDSSDAEFVDVYHTESFIQGKAEACGHVDFKMNWGEIQPGCGDLNIGCAHERAPVYFAESIISENGFWGYPEYLHRQIIGGEVSRESVLKLADEYVDRNVRGWYEVPTNTNSPFAKGRNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HER8</accession>
    <name>A0A8J2HER8_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Similar to Rbp1: RNA-binding protein 1 (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HICCMSTLAB_LOCUS8627</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5097277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HER8"/>
    <dbReference type="OrthoDB" id="5970at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="18"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG5097277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="94" mass="10715" checksum="610F3A07395D9E76" modified="2022-05-25" version="1">MQNSVHTMSRYREWDLSCKVYVGDLGSSASKHEIENAFSKYGPLRNVWVARNPPGFAFQRQNCTQNCSALQILKSPPSFWSTGCRNLEDSCCDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HEY3</accession>
    <name>A0A8J2HEY3_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Similar to tex10: Testis-expressed protein 10 homolog (Danio rerio)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HICCMSTLAB_LOCUS6314</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the IPI1/TEX10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5092686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HEY3"/>
    <dbReference type="OrthoDB" id="361362at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071339">
        <property type="term" value="C:MLL1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024679">
        <property type="entry name" value="Ipi1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16056">
        <property type="entry name" value="REGULATOR OF MICROTUBULE DYNAMICS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16056:SF2">
        <property type="entry name" value="TESTIS-EXPRESSED PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12333">
        <property type="entry name" value="Ipi1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pre-rRNA-processing protein Ipi1 N-terminal" evidence="4">
        <location>
            <begin position="142"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF12333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAG5092686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="622" mass="72284" checksum="86A4857F51E780DE" modified="2022-05-25" version="1">MGKNNRHKKNIKSEKSKVKLKQAKAKLLPKGQNITDTTFKVKKIVIREQLKEHDQSEILSRRKLNVKDLLTRFHHHNSSVRQEAIKELDDILKNHPSEILNSNLSTILQGLGALVLDREQDIRRDTLKTISLILGSIKPEYLAPFSGTLISYLCCAMTHITPAIKEDSLNFLDIIVEKSCHLIAKNSQKILSLFLDFISKNQTQSNRQLSTTLSSKLTTVKWRNKVFDRLSSIFSTIINDIRLRYYSQEDSMEEKKINIQEKTFYLPLYKNDTKLFHINFDNNCNDLISKKYNSEFYEFIKYIDVLMPLIFESWVEVRPQETSGENSSLISNDTKDFLTSITSIMQLIIQFIDIVKPKIDDANIALDFCNKYKNNISKYFMNSFPYSFKAVQIVADKKTAATKRQNDFESAVINTRNRNCLEQNLALSYIYMWIVSYSQTNRLNEISKQNCQKIVQFVNDSLNYWYNDPSIVSQLIKLVRLILINCSKILYKSGVNLESTVRAIIATSLKDSTLLVNIKLFKIFGDILLDQQNEINHDSNFIQFIKSLPDMLLKESIHDDIIKMINQVVLKYRQWVRVGLENNHTSILDNAKKIQIIGADNEKDSRLMICNLFYFMDGQLYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HFN2</accession>
    <name>A0A8J2HFN2_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS7690</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5095400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HFN2"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5095400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="68" mass="7409" checksum="E0F5D493D8FC94BF" modified="2022-05-25" version="1">MEQDTRAEGPQQSNSRLDIRVAFLVSPRLAGLFVNMSLGSWRAPLWDEEEQPPPPPLAPAPASSILLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HGG0</accession>
    <name>A0A8J2HGG0_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS9736</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5100663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HGG0"/>
    <dbReference type="OrthoDB" id="7617398at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5100663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="110" mass="12827" checksum="FCAF5BAF1A4E034F" modified="2022-05-25" version="1">MEVVGGRNNMRKIRALDKEGKGLLLIEFEGLEKKKEVMEAKSKLRGEKIRVKDDLTYEERRIKKIVMEEAFKERAAGKNVKVGYMTLLVCGKLRQWDEAEGRWKLEEGNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HH01</accession>
    <name>A0A8J2HH01_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Similar to Glra2: Glycine receptor subunit alpha-2 (Mus musculus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">HICCMSTLAB_LOCUS9882</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the ligand-gated ion channel (TC 1.A.9) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5100809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HH01"/>
    <dbReference type="OrthoDB" id="407674at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005254">
        <property type="term" value="F:chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005230">
        <property type="term" value="F:extracellular ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099095">
        <property type="term" value="F:ligand-gated monoatomic anion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18992">
        <property type="entry name" value="LGIC_ECD_HisCl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19049">
        <property type="entry name" value="LGIC_TM_anion"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.170.10:FF:000024">
        <property type="entry name" value="Histamine-gated chloride channel subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.390">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006028">
        <property type="entry name" value="GABAA/Glycine_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006202">
        <property type="entry name" value="Neur_chan_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036719">
        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038050">
        <property type="entry name" value="Neuro_actylchol_rec"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006029">
        <property type="entry name" value="Neurotrans-gated_channel_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018000">
        <property type="entry name" value="Neurotransmitter_ion_chnl_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00860">
        <property type="entry name" value="LIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18945">
        <property type="entry name" value="NEUROTRANSMITTER GATED ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02931">
        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02932">
        <property type="entry name" value="Neur_chan_memb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00253">
        <property type="entry name" value="GABAARECEPTR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00252">
        <property type="entry name" value="NRIONCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90112">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane pore"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00236">
        <property type="entry name" value="NEUROTR_ION_CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10 11" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8 11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-0675">Receptor</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="250"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="312"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="413"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel ligand-binding" evidence="13">
        <location>
            <begin position="51"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel transmembrane" evidence="14">
        <location>
            <begin position="254"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="341"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="343"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CAG5100809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="434" mass="49628" checksum="A9059D04CCFCE38B" modified="2022-05-25" version="1">MSRFWERGSAAYTDVHLLIYLLLLTGFLINDTYAQKSLEFYDLLPEDPKLYDKMRPPKKDGQATTVFFHVTVMGLDSIDETSMTYAADIFFAQTWKDNRLRLPENMTSEYRLLEVDWLKKMWRPDSFFKNAKSVTFQTMTIPNHYLWLYKDKTILYMVKLTLKLSCAMNFLIYPHDTQECKLQMESLSHTTDEMIFQWDPDVPLVVDENIELPQLQLVKNYTADCTQVYSTGNFTCLEVIFVLKRRLGYYLFHTYVPTCLIVIMSWVSFWIKPEAAPARVTLGVTSLLTLSTQHAKSQASLPPVSYLKAVDAFMSVCTIFVFMALMEYCLVNIVLGDNDAPSAPKPPPPPPATTSTSTGDTKLDKIFDIASKENAMLLSGRSQKSANLAPPPGLTPAQKARLRALNIDRTSRVFFPAVFALLNITYWIIFAKYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HHC5</accession>
    <name>A0A8J2HHC5_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS10093</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5101020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HHC5"/>
    <dbReference type="OrthoDB" id="10381212at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035248832" description="Secreted protein" evidence="1">
        <location>
            <begin position="21"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5101020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="158" mass="18147" checksum="85B728F7389D7A71" modified="2022-05-25" version="1">MIGLVVCACALVIASSGVLTENVTIETTELSNSTESHSINKRNALLDAWEEFKNYMHYFIRGWFRRSDDAQNSDSEIDECIKKCSNVSSTKTRLLKREVLSDLLEFLQVFFGDLWHVIKLVPEKGLTLLDGFFKNLSTFHRQNLLRVNEILKIDTDED</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HHE6</accession>
    <name>A0A8J2HHE6_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Exportin-4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HICCMSTLAB_LOCUS10354</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the exportin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5101281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HHE6"/>
    <dbReference type="OrthoDB" id="5548448at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005049">
        <property type="term" value="F:nuclear export signal receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006611">
        <property type="term" value="P:protein export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044189">
        <property type="entry name" value="XPO4/7-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12596">
        <property type="entry name" value="EXPORTIN 4,7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12596:SF1">
        <property type="entry name" value="EXPORTIN-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00040444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAG5101281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="1038" mass="118010" checksum="3D58135DACD2D43D" modified="2022-05-25" version="1">MPYQLCREILETSSVDYVLFESAGLIKGALVREWTLLPSADIGSLQQYLLHYIVNKPTLAPFVRERILQVIAIMVKRKSVEDSGANRGVLLNQVESMVTSGDSKRQLLGCSIMSALMQEYATTAKSSEVGLTWDLHFKAKQQFEITDLKRIFKFVTTALSELTKDSVPMETLPLIKHLLSIAEAALTWGYVIFDSMSQGLIRLFEDFSESEASPSLRPEKVWQDVILDPMIIQIFFTLYWKVRTNLQLAHHARSCLVQLASLNGKVMATHELKLQYSSNYVQNFIKLISNIEIIDQEALGVANIVRRITMFFGLTLQSLAPEIFGSFMEQVTRLTCIFAEGAAQEDSMCPDDYLYMEAFERMLESWSSILSKKSRYQDSFFEPSFVQIFNVYLKCRLSPPDGTRSLRQELSQLTSSQRESFVAHGNMNEALQNLYEDLHWLVLIAGHILCFDSIGEVALIPAQMIKYSMEQAEQGKSDVNVSLQLMASPQCNLSDIPGAEESSDHVIRLTAAIFRLCEIKRSAIEANLANLLSPELISSVVWFLHRWSLSYLLPTENYYSEISTTLIQAFGTDGAGAQWAVNFLLDNIKCIINVFKGEETLAEDTVKLLVGLVDTPTKSYYVLKSEQIGSLIDLATKNSFSLPQVAKRGIMSTVVQVGIALKNKSNEKQYWSQTLQPLLDQFKQIISRNDFSRSCHQEDIKLQITELLEFFIGIAQGAQSSTAKTIFQYICPVLAEVANLLTAYHNYPQIVKLLIEFLFECTRRILCYLTEEEGIKLYEASLHTIQSYARCNSNRITTDSTNEENTYEDILLLMQLLTHLLSEDMFRLDRVDSKSRQKQLVTSADVFLYGLNIIMPMMTLELLKFPSLCHQYFKMITLICEMHPRKVCELPLDLLKQLMASVELGFYSFGNDVTNICCDIIRLIAKYLHGENLKGHPKNPIIAPFMNVIMNLVLSQQIYSDLISYISTPMYYLICCYQEEYQKLVENFIASQPNQVVAQRLATAFNNLTANISMTTEQSERLKFRNNFESFAVAVLIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HHR3</accession>
    <name>A0A8J2HHR3_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Palmitoyltransferase</fullName>
            <ecNumber evidence="7">2.3.1.225</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HICCMSTLAB_LOCUS7980</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:36683"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="2.3.1.225"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="7">The DHHC domain is required for palmitoyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the DHHC palmitoyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.225" evidence="7"/>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5095981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HHR3"/>
    <dbReference type="OrthoDB" id="302728at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001594">
        <property type="entry name" value="Palmitoyltrfase_DHHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039859">
        <property type="entry name" value="PFA4/ZDH16/20/ERF2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12246">
        <property type="entry name" value="PALMITOYLTRANSFERASE ZDHHC16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01529">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50216">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="79"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="110"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="135"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="Palmitoyltransferase DHHC" evidence="8">
        <location>
            <begin position="32"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU079119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAG5095981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="226" mass="26605" checksum="AA992D9B9B8E7687" modified="2022-05-25" version="1">MINIVGNYTYAVMCDTSTRPVIMSISKAKVKDGWRFCSSCEAVSPPRSWHCQICNTCILKRDHHCVFTGCCIGYLNHRYFLMLVFYIFIGATYSFYYNNYFIWSKLVFEFPLSIIKIIFPLAIFIFGFDDSWEQFYLMIYIISVVGMLFTGALFIYHIRLVCNGTVAYEKDKNISKYNIGWKDNIKDVLGKRWYVCWLLPYIKSDLLHNGLFWSTVGSWKDNSKHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HIR0</accession>
    <name>A0A8J2HIR0_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS9688</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5100615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HIR0"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5100615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="73" mass="8263" checksum="482EA0624558A067" modified="2022-05-25" version="1">MDPLLVLLGDLDSREAIWIFNYLPCQHRDLRGRSLLKGLVGLGSRLRASIPTAPPRIVAVLEWFMMALETDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HIX5</accession>
    <name>A0A8J2HIX5_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Olfactory receptor 33.1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HICCMSTLAB_LOCUS9246</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5099811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HIX5"/>
    <dbReference type="OrthoDB" id="6617147at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005549">
        <property type="term" value="F:odorant binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004984">
        <property type="term" value="F:olfactory receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004117">
        <property type="entry name" value="7tm6_olfct_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21137">
        <property type="entry name" value="ODORANT RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21137:SF35">
        <property type="entry name" value="ODORANT RECEPTOR 19A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02949">
        <property type="entry name" value="7tm_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0552">Olfaction</keyword>
    <keyword evidence="8 11" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="9" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="42"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="65"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="126"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="204"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="265"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="297"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="365"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAG5099811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="391" mass="45197" checksum="EED14BD42F9F9AD4" modified="2022-05-25" version="1" fragment="single">NIFTQKQLKEAKSLLGKVSWLMSLLGIWPVEKTRFQRIKFKVYVAYVTLHLAMTVNNLVANFSNVKLVTIIIQQLMGIGMTFNRLLFINYSSNVSEIIKTTKEEIAYAALTDITEKKIFIKLHKAASLYYHITIKFMVFTSLYYYSLPLIKNLDLKEYSKASNVMVQKIIKVFFFNSSSLKRTFFLHIYELPALFMQPNFCASVNMQVIIVMNLAAQMAILGQRIKNLDLKEYSKASNVMVQKIVIRHMELTKLAKKIENTWTPIYCIELGFYMPLTSLVIYNAMNMFNNNQKLLAVPYYIYIIVTLSSLFGHCLMGELVKTQSENLLDAYYNSNWCEMPIKYKKSILICMTYTKIALNITAGKFFVYSLSAFTGILKSIMAYVSLLREVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2025-06-18" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HJ08</accession>
    <name>A0A8J2HJ08_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Pecanex-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HICCMSTLAB_LOCUS8737</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the pecanex family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5097497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10037631at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007029">
        <property type="term" value="P:endoplasmic reticulum organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039797">
        <property type="entry name" value="Pecanex"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007735">
        <property type="entry name" value="Pecanex_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12372">
        <property type="entry name" value="PECANEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12372:SF7">
        <property type="entry name" value="PROTEIN PECANEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05041">
        <property type="entry name" value="Pecanex_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="60"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="1018"/>
            <end position="1038"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="1045"/>
            <end position="1065"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="1085"/>
            <end position="1102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="1133"/>
            <end position="1150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="1184"/>
            <end position="1202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="1208"/>
            <end position="1227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="1329"/>
            <end position="1351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="1357"/>
            <end position="1374"/>
        </location>
    </feature>
    <feature type="domain" description="Pecanex C-terminal" evidence="9">
        <location>
            <begin position="1845"/>
            <end position="2069"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="152"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="241"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="497"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="561"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="632"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="683"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="2134"/>
            <end position="2180"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="800"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="152"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="259"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="498"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="510"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="569"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="636"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="659"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="683"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="2134"/>
            <end position="2147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="2150"/>
            <end position="2159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU367089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF05041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAG5097497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="2314" mass="260793" checksum="9480040E69354819" modified="2022-05-25" version="1">MGSQSLEILRQGVWASLTGGWFYDPHLDVFSNTFHLYVWLFLLCFPFTIYLFLPPTFHVWLAYCASILMLFGTIKCVNHALHCVYDTGKRLEEPGPCVSLKKSESEKQRAARSKCIDRCLDQADLGIELQILNGKTDTPPVECSSRNSYIEQNAPSADADSITSEYNRDKPNSTIDLKVEIHRKNSSESSEEAQQLSKPTVTCINVQDAELVSTQDREPRLRAKIDDWRLTHQTCVVQIKDRPSSRKLCRHASEDSQSRHTNQGTLGKTGSESRIKQTSSLELEQHGEDYPYWKSNQSVRRLTSNSIPMETHLTTDHPQSLETISKKKDLDKIKMPSHPQSLEVIAKKLHQQQVHPQSLETIGATIKNVDASDDNNLPLHPQSLETINTKKILPQNTLKRNQLQLLPYLSYGSEIVHPIAEQSDEQFANESAGGFSLRDSYSPLLTRKTIGDSSTCPNRDRSLSAGGFEDRFSRFNGEVVIDNDSANSREALLDKGQSSFSRRFSNGSRSSHELSDGDRRKESQEDNVNRVDDLVNSGSVVGLDWLFENHECTAESWANKNFHSKEPDSGSSSTTTLSIDNEVRKTLLPAPSTIDSKRHQGAIPKQNRPKVCPENLINNSINICSALETSTNKPRRTIESRRDRDRKQAKDMSQFEQASSSNNELSTLLSTPAPPLLASLLKSDSQVSGSNGPDNAPSAVRIEIPVPNISRRNRTRRLKRQRVYRRPRHEDNVGVFTALEGLISNGDYHIATNHNDTSEGAIHYFHDDNGRWFAYKFDEKDPTSATTAPVPPGGINDKFINSLLHQQQQQQQQQQQQQQQQQQQQQYHQQQAQQQQQQRSHNIPIDGNCLTDSLSNSYSSLSMNSAGLTLIIDSPPVLSSPANNQTKTQNSLPANILSTNTGGNSNVFDQPTVLFDHDFYCQIRASRNCRIHHLFENINVNAQQPENQNQVVVLPLPNHQESDIHNSSSWNRFCDGMDPNDSKSKPTRHYYKWKIGKFPHIKVRFDRLSLLALLDRNLTILETTISTILAVTVAGLGLQLLQKGFYRDIFAFIFCFVTAGCQYSLLKSVQPDAASPTHGFNRIIVFSRSVYYIIVSSIVLILNESLHNFKNSEFQVYGLRVTDYDTINQVKNILLIFLLVFPLIFSLGLFPQINTFLMYVCEHLDIHLFGGTATTSLVSSIYSLGRSVVTVAILYGFAYGALTEPKSSQHILFSIFAGLLVAISYHLSRSSSDPSVIWDIVKTNVWPPEMYLEEIGAKVIENTSRQDSTPATIVTTTTATINKDTKIKTTGRKKDVKIKVGEQITDSELVDPLPKKLRNTVKARLKNDLIVCIVIGVLSFIIHCSTIFTALQSQINHVLWGVVSCLGFILHYIIPQLRKQLPWLCLARPVLRSHEHAQFEVREPVKIMWYEKIYVYLCFIERNILYPIVFLWALTECSSKIVNKFGENVGALIIVVCGLKSLRSAYADPSSRYLVLAFSLLFFRYDYKHLSESFLVDYFVTAIAYAKIHELLLKIRFVITYIAPWQVTWGSAFHAFAQPFSVPHSAMLFLQATISAILSTPLNPLLGSAIFICSYVRPLKFWERDYKTRRVDHSNTRMSSHLERNLGADDNNLNSIFYEQLTRSLQHSLYGDLALGRWGNVEQGDCFLLASDYLNCLVHVIQLANGLVTFQLRGLEFRGTYCQQREVEAISESIEENDNCCCCEMGHFSNVLSMNAAFGQRWLAWEVASAKYVLEGYSISDNSAGSMLQVFDFRKVLVTYYVKSIVFYVIKSVKLKQWLDNKDITDSLKPTLEKTFVDLDPVFNMNIDEDFDFRANGISRSSFCNVYLDWIQFCAVKVDKTLERTRDSYLVSLCLALSLLGRRVLGAASHNTVSSVEFFLYGLHALFKGDFRITSVRDEWVLHDVDLLKSVVAKGVRMALKLHQDHFMSPEQYDDPAALYEAIDNHDRHLVISHEADPLWRNAVLSGAPSLLALRHVVDDGIDEYKVIMLNKRFLSFRVIKMNRECVRGLWAGQQQELVYLRNRNPERGSIQNAKQALRNIINSSCDQPIGYPIYVSPLTTSYAETNKQLCSIVGGPFSLNTIKNNVLKIWRKVRRRCGEGCSSGGTGSQDDGGFGNDGVYAMTTYNIHSGYSQSGHNTSGSQSMDSGCQIGGSTGRGSLGRANTGSLGGNRGSLASVGKPTSSTLASLAGLLSNNDIKTESKCETSFSNKDKEEISQRVRIMDPNQVYDAINLGRRIDVIWPDEKMRQQGGRSGWQHWVPERGMEGCVVHRWLPNHRDPNRRSHVDKVILLVKIEDKFVPIAEQGVRDLGAEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HJ34</accession>
    <name>A0A8J2HJ34_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS11334</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5103087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HJ34"/>
    <dbReference type="OrthoDB" id="10527726at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5103087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="199" mass="22765" checksum="E8957526DCD6DE03" modified="2022-05-25" version="1">MNTFKDESKKFLFQTLIGKQLYIQRGLSWHNTGLPRFGRTILAHDWTTTQLTSLGLPVLDQDPANIQLTSLGLPVLNQDPANIQLTSLVKLLLYQDLANMSICNKSYWFASLGPRPSQYSSDKSWFTTLGPRPSQCLCNESWFASLDSRVNQYLINKASQKKKVNFFLRIECEEWEEANYFDVTNKLQFIREGGGVKMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HJB0</accession>
    <name>A0A8J2HJB0_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="6">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HICCMSTLAB_LOCUS8510</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the PPP phosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="6"/>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5097037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HJB0"/>
    <dbReference type="OrthoDB" id="1930084at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07415">
        <property type="entry name" value="MPP_PP2A_PP4_PP6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000005">
        <property type="entry name" value="Serine/threonine-protein phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047129">
        <property type="entry name" value="PPA2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45619">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE PP2A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0464">Manganese</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="7">
        <location>
            <begin position="108"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG5097037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="303" mass="34826" checksum="CBB4A9D0D2C06480" modified="2022-05-25" version="1">MSDIDNWIDVAKQCKYLPENDLKKLCDIVCDLLLEESNIQPVSTPVTVCGDIHGQFYDLEELFRNGGPVPDTNYIFMGDFVDRGYYSLETFTRLLTLKAKWSDRITLLRGNHESRQITQVYGFYDECEMKYGNANPWKYCCRVFDLLTVAALIDERVLCVHGGLSPAIRTLDQIRTIERNQEIPHKGAFCDLLWSDPEDVDAWAVSPRGAGWLFGSKVTHKFMEINDLELICRAHQLVHEGYRYMFDDKLVTVWSAPNYCYRCGNVASILNFTSVDQRSTILFQAVPDSERVIPSLTITPYFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HJC9</accession>
    <name>A0A8J2HJC9_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS9066</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5099442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HJC9"/>
    <dbReference type="OrthoDB" id="10315930at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035308750" evidence="2">
        <location>
            <begin position="22"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="97"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5099442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="144" mass="16472" checksum="D44F518609E5AFDE" modified="2022-05-25" version="1">MDSKLFCVIISAMCALQLVYSCPLDDYDNLYVQDKQNISLYFARLHVMGRVFISDLQFIRDQITSDPNSTMNDLETAWNKFSKNMTDIKNNDNIRPVDLLLRDLEKIQNGIADYQSKVALLKEKTSGADANTPVKELLEAMLKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HJH7</accession>
    <name>A0A8J2HJH7_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS9172</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5099663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HJH7"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5099663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="107" mass="11815" checksum="82D8ABB8783B1011" modified="2022-05-25" version="1" fragment="single">MLDSSRGAECVDRTKKFKFSSSSLFYVPRSSYQSIGPGSNPAYTNEYFQYLSVLFCSAQEIQTSSNLKSLPPTVVAHDLNNDNDDNDNDNDDEDEDDGGCGCTQFTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HJK2</accession>
    <name>A0A8J2HJK2_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS9217</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5099753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HJK2"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5099753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="307" mass="35749" checksum="532AF919DE9BFD7B" modified="2022-05-25" version="1">MQQTEIGRDRRPDSETRDRVRIKQEIIDAEVKVKVKQEVQVKLEEENNTNYENGFAIDQDLERKTGGNFGRNCPAMHPAYRAVGGPGPPNSFGFPHFFPPNSFGIPNFMDPQSQHSEQEKIHFSKNFLHPRQEKIKDLEYRNYEQKFDMYHFRTPPEFSQLIQQQHSMRSLYSGKHSRKWSNNLPAKFVQPNVSFGKELELKPEGKSMQSFSVILNLHLSPSRSCMGTKTLSVELNRYVVIRGRTISRYCVIYSEKWFHCEIASSAYIEEVSIGINIQQRKDAVITTHLDFRLRKEEKTDDTSQSSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HK33</accession>
    <name>A0A8J2HK33_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Similar to tdrd7b: Tudor domain-containing protein 7B (Danio rerio)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HICCMSTLAB_LOCUS10539</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5101637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HK33"/>
    <dbReference type="OrthoDB" id="10034606at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007283">
        <property type="term" value="P:spermatogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00048">
        <property type="entry name" value="DSRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09972">
        <property type="entry name" value="LOTUS_TDRD_OSKAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20379">
        <property type="entry name" value="Tudor_dTUD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.90">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.610">
        <property type="entry name" value="LOTUS domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014720">
        <property type="entry name" value="dsRBD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041966">
        <property type="entry name" value="LOTUS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025605">
        <property type="entry name" value="OST-HTH/LOTUS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035437">
        <property type="entry name" value="SNase_OB-fold_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002999">
        <property type="entry name" value="Tudor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050621">
        <property type="entry name" value="Tudor_domain_containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22948:SF29">
        <property type="entry name" value="FI02030P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22948">
        <property type="entry name" value="TUDOR DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00035">
        <property type="entry name" value="dsrm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12872">
        <property type="entry name" value="OST-HTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00567">
        <property type="entry name" value="TUDOR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00358">
        <property type="entry name" value="DSRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00333">
        <property type="entry name" value="TUDOR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54768">
        <property type="entry name" value="dsRNA-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63748">
        <property type="entry name" value="Tudor/PWWP/MBT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50137">
        <property type="entry name" value="DS_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51644">
        <property type="entry name" value="HTH_OST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50304">
        <property type="entry name" value="TUDOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0221">Differentiation</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0744">Spermatogenesis</keyword>
    <feature type="domain" description="HTH OST-type" evidence="9">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="domain" description="DRBM" evidence="7">
        <location>
            <begin position="363"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="domain" description="Tudor" evidence="8">
        <location>
            <begin position="581"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="82"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="340"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="92"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="143"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="156"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="201"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="279"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAG5101637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="1120" mass="125646" checksum="C424CF4B157DDF74" modified="2022-05-25" version="1">MEEIGKTLKSMLLAYKGGVAVENINRDYKDMFEEYIPFRKYGYANILEFLKDVPTIRLVSRNGTIYAQALVDEKNKHLADLISRQKTPKSKPMSSRRPTNTYSGNYNRSSSAGRYSSNPRPNFSARYGRSQSLHRPADQPTTRNWSSNSSSRSEATRAQNFGCNGSQKKPDDRFYMPKPQNGFQQSSSKPEADRAPARANNGFQNQSSSTSPPMNHRVSNLHNISMGRNSQAQNMSGSSFSVTRRINSSGNIPPLIPPTDRKSPVSPTNTSFKPKPLSPNYSSKTSETFNDSGPKPQLKPLSERLKNPLAFSPPIIEPKQPETPCNADKRVTFAPSVEIKPNVNPGIKQLPLTPPLTPRSFNDPREELTDLAFQMNLPPPEYVCTDSGKRNPKTVYSQITIGSMKFSSYPADAKTKNDAEIIAAEQALADLRVKYQSQVQLPITFDKAVIKDRVIDIVINDNHTSGIFKHKLPQYYQEKYKETLPLDWDNVLASCFSKITCEKVLNDGIILLPYNPATDDIDQPPMPELVLPQEELWPVYITSLISTEEVYGIILDDDYCLRRDTMTDKIEVFYSKVQPKPASVKVKRYYAVKKDDTWQRVYVDFIDTESESADVFFIDTGDVDTVSLNDLCTLDRSFYELAPQAVRFSIAGYDELSSYNVINKIGVELLTNLSCYVQVMSREKNDLGVLINGVFYDTSTDEDINVNDLILEKLIKTVSSPKLTSEGEVLEVYLSHVDEDTGGVFIQINNDSFEVLSALIEKLTAEINDEVLKRAAVKWSWVTRDVAYLVRLPEGPMARVKVIQQPQGDRLNVLLVDIGKTMVVSASQLVRIQMIPPAHDNNLKLLAAAVEKYPVQTCGIQLHNTRTSVLSDKRILKPLREMAPPKVKLFCKVIKEAKDSLAVVELFKRGGKDKDYSLISINNTLALQLVSAEDEDKNNNLKPKSRIFDRKNSKTNLSPKGLEIMSKPEIPNIGEFFDVHVTQTVTGPNHFVVQPYHGTEALTILEEELQAYCEGSKSFVKNEDFGTVDSLCAAKVDNKWQRAMVAGVFDARSTIVYLCDSGVMRNLDNKLVGEKDFVSIIRKIEPDTVSPTKQIVSLELIDTSGSEDKNILSELMKLDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HKG5</accession>
    <name>A0A8J2HKG5_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Similar to CDC45: Cell division control protein 45 homolog (Homo sapiens)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HICCMSTLAB_LOCUS7429</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CDC45 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5094878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HKG5"/>
    <dbReference type="OrthoDB" id="10258882at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031261">
        <property type="term" value="C:DNA replication preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902977">
        <property type="term" value="P:mitotic DNA replication preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003874">
        <property type="entry name" value="CDC45"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038763">
        <property type="entry name" value="DHH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10507">
        <property type="entry name" value="CDC45-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10507:SF0">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 45 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02724">
        <property type="entry name" value="CDC45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64182">
        <property type="entry name" value="DHH phosphoesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="7" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="135"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="138"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAG5094878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="580" mass="66775" checksum="12F99AC4206572A1" modified="2022-05-25" version="1">MFVEDLSNDFYGIVQGKRCLLLVNFDVDAICACKILQQLFKNDNIVYTLAPVQGLKDLIKAYEDNAEEIKYVIMINCGSTIDIVEILEPPEDIIFFVIDSHRPYDLCNVYSEGQIRILGKPTDDEEIPEYDEIFREDSSDEEDQEEEEEEEDDNLDEEMVESRQAKRRRLNEEDLLKRRARREWEEKRDTILFNYMQYSYYSKSSAVIIYEMAWKMSKDSLNMVWWAIVGSSEQSILNKIESSESVLEIGRLQSHVSRLSHRQGVDSDQQQLSAAKVTYDKDIQLALYRHWTVEASLRHSMTTAVSLRLWSIRGDQRLRGLLAEMGLPLDQSKQRFTAMDLNLRLEFREMIERLASKYNVDSIVGASFTIQSGYTFKYCASDIVYAMLALLESSTKDRSPQHCFLDALDCLSLKKKQVLQRGIEKAKLMLSNIFKTAQGILEMKQVMNAGSFLYVTIPEGTLDSRLFAHPHPLIMLAQFTLKAYVETSKRHTRVLPMLASATFNPDEGTCILVGVPPVCEDQPRSLFGKAFEQAAKNTNAHIESDYFDTTIIRLKIEERPKKKHLPVPQDLRGVQPDPQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HKQ8</accession>
    <name>A0A8J2HKQ8_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS10486</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5101584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HKQ8"/>
    <dbReference type="OrthoDB" id="7614304at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="89"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5101584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="158" mass="18591" checksum="BA5FBEA9E9D2525F" modified="2022-05-25" version="1">MTTQSTDVATTESYRQSRAYRRGEDHNHNHDHDHEEEEEEEEEEEEDNQADMDQMDVDGDMDSKSLAESKGEYWGGYYDFLINEGSYKFWAVFQLATAALLIYSGFAALYYAKVNPSTTDDYEDYFLRRRKRHISDTLFKLDDATFQRIIDALELNIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HM21</accession>
    <name>A0A8J2HM21_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Similar to Znf800: Zinc finger protein 800 (Mus musculus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HICCMSTLAB_LOCUS13117</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5108197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HM21"/>
    <dbReference type="OrthoDB" id="10066279at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039149">
        <property type="entry name" value="ZNF800"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21020">
        <property type="entry name" value="ZINC FINGER PROTEIN 800"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21020:SF0">
        <property type="entry name" value="ZINC FINGER PROTEIN 800"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="102"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="287"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="643"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="786"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="830"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="789"/>
            <end position="800"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG5108197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="915" mass="104546" checksum="D102C61C1E5A169F" modified="2022-05-25" version="1">MNCNLYYIMHFYKLLRHINLYYNISGSKMKAKTKTKKSDRKFTRHKLTPKDSPQIETPICDFSNLCKPIDTSLSNLVQVTKLLETANDEIKYILTYECEVIYECKICRSLFRSLLNFISHKRIYCPEKFNISNNKDVINPQVMVVEKSIDSECEENYEDQKSSKNEALNRKFSKKDLTSVITMLQKKQADPNYNDVEEKNRRTRIVADTEQVLLEVLDSNRAAFQTVLEPKLSNIASNDLMKAQTIELQNILNRDTAVLGPDGSIVEFRNDGKVDNKDIDKVSNHNLVCSTCNIKFATKKTLTFHIKSLHTPNRLVYPCPCCPSLFPSTWGVYRHLVKVHRKSNAQVRKLRSEIQTKAYLKETTRAQDIDKDCANNKLNNSKESRLMNETQEWMTHLESDTELQRCGGCNKRFDRKAALLAHSQICQRRQAVCSDVAIRSKRNKIASEANTEKISTLTEVSKPTKENLQIPIKKMSMESESRVISSSVNSTSLLNLSNISPAVSITRLPQQQQANEIRVEGIASLSKDAWEKIGDETSKLRVDTSVDVLTIPSEAMPTKISPNDSVSDDPEIIFTNIEKPPSILKNKGSKKRKMGKRNTSIDSNKRINLLVQENTEKMNSAKILSKSDTNLDEKINFISPQKFECIPCKLTFSNLTHLRRHMTEHMDWYRFRCKLCEFKCFNKIDCVTHCNKIHNAKNSRMNIESMIIESTFNEKSTNSSRSLLKKCHVTIPVIQNGNNSTDENDSCSVKSCEELPDENSEMVKKAKLGEDSELRRMVMEVIFGSSETVNEEEPGSSTEIEEIRDCKKNSKMPNKTYSDHEENSLNHIATMKLSSNHNRPSRNSRNRTKLENKNFIYDLDAVLVKDTATDGTGVIVEDNKTSTNIMNNESDSESDLSVVLYRDRSIVKTKLEKVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HM81</accession>
    <name>A0A8J2HM81_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Similar to AAEL000263: Zinc finger protein jing homolog (Aedes aegypti)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">HICCMSTLAB_LOCUS10838</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the AEBP2/jing C2H2-type zinc-finger family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5102084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HM81"/>
    <dbReference type="OrthoDB" id="9984614at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035098">
        <property type="term" value="C:ESC/E(Z) complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052130">
        <property type="entry name" value="AEBP2/jing_C2H2-ZnF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059034">
        <property type="entry name" value="SH3_AEBP2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46541">
        <property type="entry name" value="ZINC FINGER PROTEIN AEBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46541:SF1">
        <property type="entry name" value="ZINC FINGER PROTEIN AEBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26014">
        <property type="entry name" value="SH3_AEBP2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="363"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="22"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="260"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="62"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="289"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00037930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CAG5102084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="549" mass="60207" checksum="95BF39CC2C0C4C5D" modified="2022-05-25" version="1">MTITHYYNYVFSGVAVSCGDCSSSGTSDITEPGSPCSTSSDEGVAIHGKAPSPLPSIPKLAPQTSPLLNGTRPQWPWTPPLADTACSTYKRLNSEPEIGTLPKVTAADPTVRSTKTSNKLQHNHHQQHELQGKITEYFKTQIKPQQSKTKKNSADMSVMVAKNSPEFRRPLTVQRNKGGLAKYLGVVTPNSRSVANDWDVKSMGIPSSQLPGNKKLSSVTPRVSVMKLDKLFVNKTLPGLPISSDVLSSIPGCKISSLRLTGEASPKPSGESPPSTPTPTLEAMRSVKEDDEEEEEEEEDSSRSSESKPSSSPILCEPTTIRFPARAPTKNGARAADSGICRTSCSRRWLERHVLSHGGNKPFRCIVDGCGNRFSSQIALERHVNNHFNQPETSSSSSRRSCENGGKLVRRNGKKLRYRRQPWSARLFDYFDNGVMEGLQHRLLELAKSRTQGQLASTPGNSMALTSQVLAKRVETDGKTRVLLRWHPQDIAPDEWVLESEVINTKHIDIRKAATTSIDEVSLVLYPAVQGGTPPATRVKQRRKPVKNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HMI0</accession>
    <name>A0A8J2HMI0_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Probable enoyl-CoA hydratase, mitochondrial</fullName>
            <ecNumber evidence="2">4.2.1.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HICCMSTLAB_LOCUS11682</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.17" evidence="2"/>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5103783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HMI0"/>
    <dbReference type="OrthoDB" id="2018133at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004300">
        <property type="term" value="F:enoyl-CoA hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.226.10:FF:000019">
        <property type="entry name" value="Enoyl-CoA hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.12.10:FF:000001">
        <property type="entry name" value="Probable enoyl-CoA hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.10">
        <property type="entry name" value="Lyase 2-enoyl-coa Hydratase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018376">
        <property type="entry name" value="Enoyl-CoA_hyd/isom_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014748">
        <property type="entry name" value="Enoyl-CoA_hydra_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11941:SF54">
        <property type="entry name" value="ENOYL-COA HYDRATASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11941">
        <property type="entry name" value="ENOYL-COA HYDRATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00166">
        <property type="entry name" value="ENOYL_COA_HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00073937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG5103783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="293" mass="31817" checksum="A9390E1EEC0B4A87" modified="2022-05-25" version="1">MAMRIISRNFINRLPKNTQNFSTSTKLYAASVLNKYEFIKAEKAGEKQNVGLVTLNRPKALNALCQQLITELNDAMEKFDLDESIGAVVLTGSEKAFAAGADIKEMASNTFAGNLKGSFLQNWSDISKIRKPIIAAVNGYALGGGCEIAMMCDIIYAGDKAKFGQPEIIIGTIPGSGGTQRLTKAIGKSKAMEMVLTGNQITAQEAEKFGLVSKIFPADQLINEAVKLGEKIAANSQLSVALAKEAVNKAFELSLQEGLSFERRMFQATFALDDQKEGMSAFIEKRPPKFKNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HMT9</accession>
    <name>A0A8J2HMT9_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">phospholipase A1</fullName>
            <ecNumber evidence="4">3.1.1.32</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HICCMSTLAB_LOCUS9124</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 2-acyl-sn-glycero-3-phosphocholine + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18689"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="ChEBI" id="CHEBI:57643"/>
            <dbReference type="ChEBI" id="CHEBI:57875"/>
            <dbReference type="EC" id="3.1.1.32"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the AB hydrolase superfamily. Lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.32" evidence="4"/>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5099568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HMT9"/>
    <dbReference type="OrthoDB" id="199913at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008970">
        <property type="term" value="F:phospholipase A1 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017171">
        <property type="term" value="F:serine hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013818">
        <property type="entry name" value="Lipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000734">
        <property type="entry name" value="TAG_lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11610:SF37">
        <property type="entry name" value="GH01208P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11610">
        <property type="entry name" value="LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00151">
        <property type="entry name" value="Lipase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00821">
        <property type="entry name" value="TAGLIPASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035298292" description="phospholipase A1" evidence="9">
        <location>
            <begin position="20"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="domain" description="Lipase" evidence="10">
        <location>
            <begin position="29"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="domain" description="Lipase" evidence="10">
        <location>
            <begin position="279"/>
            <end position="529"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAG5099568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="565" mass="62756" checksum="7E14C129F842F7F5" modified="2022-05-25" version="1">MNILNRLLIINILIISITAEGIDEISEKLRIKIYTGNSIKSAKIVNFRMNRPDLIYQYIDNAKSLVLYAFGFTEKPDDESVRTIVDAYLNRGTVNMLVLDWSKLSYEEYFSLIPKVRVIAKITAKTIDRLFELGLNLDTFHIVGHSMGAPLAGAIGEFSEYDLPRITGLDPAGPGYDESKAPNLNYNNAIFVDIIHTDMGVFGTTKPNGTVDGFANGGKRPQPGCPRLQSVQDTAGICDHRKSWRIWAASIINPKAFRALKCPSYSDYLAGNCKNNDAVYFGLFTPTNANSTKSAKIVNCRMNRPDLIYQYIDNSKSSVLYVFGFTEKPADESVCTIVDAYLNRGTVNMLVLDWSKLSYEEYFSLIPKVRVIAKITAKTIDRLFELGLNLDTFHIVGHSMGAPLAGAIGEFSEYDLPRITGLDPTGPGYNPPLTTHHLNKKNAKFVDILHTDIGFFGITKTDGTADFFANGGKRPQPGCPRLQSVQDTAGICDHRKSWRIYAESIINPKAFRALKCPSYSDYLAGNCKNNDAVYFGLFTPTNARGFYYFDTSKSLGLVNTVKAIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HNL8</accession>
    <name>A0A8J2HNL8_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS9747</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5100674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HNL8"/>
    <dbReference type="OrthoDB" id="7699017at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5100674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="124" mass="14509" checksum="52B96D62975DA83B" modified="2022-05-25" version="1">MSEQNQKLVKNNLLKHLLQELNLSAGSIEDILDNVLDKTFNTVDDNLGTIYKRKKFYEKNFPYVSPIQIPLNNSSSKKKQFFHYVPLKGTIKHDIFEGVLAYDLKLYLDDLVDKGWFSYKLLNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HNU4</accession>
    <name>A0A8J2HNU4_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Similar to LUBEL: E3 ubiquitin-protein ligase lubel (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HICCMSTLAB_LOCUS12469</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5106856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9978677at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071797">
        <property type="term" value="C:LUBAC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036435">
        <property type="term" value="F:K48-linked polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070530">
        <property type="term" value="F:K63-linked polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990450">
        <property type="term" value="F:linear polyubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097039">
        <property type="term" value="P:protein linear polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20337">
        <property type="entry name" value="BRcat_RBR_HOIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20351">
        <property type="entry name" value="Rcat_RBR_HOIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047540">
        <property type="entry name" value="BRcat_RBR_RNF31-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002867">
        <property type="entry name" value="IBR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047542">
        <property type="entry name" value="Rcat_RBR_RNF31-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026254">
        <property type="entry name" value="RNF31-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041031">
        <property type="entry name" value="RNF31_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044066">
        <property type="entry name" value="TRIAD_supradom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16004:SF2">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE LUBEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16004">
        <property type="entry name" value="RING FINGER PROTEIN 31-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18091">
        <property type="entry name" value="E3_UbLigase_RBR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01485">
        <property type="entry name" value="IBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22191">
        <property type="entry name" value="IBR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00647">
        <property type="entry name" value="IBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51873">
        <property type="entry name" value="TRIAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="10">
        <location>
            <begin position="1286"/>
            <end position="1522"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="9">
        <location>
            <begin position="1290"/>
            <end position="1339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="77"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="126"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="887"/>
            <end position="923"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="983"/>
            <end position="1060"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1090"/>
            <end position="1125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1206"/>
            <end position="1234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="85"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="133"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="896"/>
            <end position="916"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="997"/>
            <end position="1049"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="1105"/>
            <end position="1121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAG5106856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="1707" mass="192095" checksum="7E96732AAA205977" modified="2022-05-25" version="1">MRIWGPPAGVENDEAAPRKDAANEAGVAGLSELVGGAMDLDALKQVIPSLDNLAELQAGCKQDSTRTKPTDQLLKNVQEADDKNIGNNSNDLSNSFKDSDKPCTSPSSKTDLNKLESGKILLQENGDIGNKIESAEQKSDEKDIEQTEEIKNQSDSSAKNLAVENLLLATKLSEQVPIEEFSAKLEPKVVSNDKIDEILNVPIETPQVSTQASEIVDKEVVKEENKLEVNLPVKISSEEVVKIEQEVIEEKPIKEDVKLSIDASSESKKLLETEETVVETNSPVKEEIIVGSVSEVDKSDILNITKNKDEEVFDKAVRISESEIKFESQEKLNQATPTVLSAPPSRMTALKSLKNRLTSMISKFPSMKLSYEKPESMGINQVNYKESMDSSLYSHPNLIINNINQHASNGINNHNNTDKLNDDIISLDCASTQNHLKTFISSATITPTNKEVVQKINGINKYNETINSASSSDDQAVLKNNTKEYESSVFFQNTLSNPESRDIKRSTMYIEPLMVSKDKKNEDYVKNNVEVVATVDVEVNEENHKLKDQDLKIKMTETENNYKNLQIYQEVDNVMEYNNFEKIDSNENNMEVDIVNESGDKDDLFVDASSSPETFELKITEAPLLIVNDAAPVENPAVVRGSLTINLSQFSDMKELTTEMLQFASQEILENESTGPLSPLEAELPEIFSASSKIETSIEINESAVKTDSVQTNYFIPKPKGRSKSPVKRSFVLRKLPARKCFVGTKRSFNFGGVPKDTALTRAKECADKIAAKSLMSSRSVNQVKKAEVVDVNRKGECDKKQELVSQTEKVEREKKMNLSSQKIDKNFINKPTPKSKLPSRIPIFQKKPWVAGQTISVASQKIIEVNVLKPTNSSFNVPRRTIPVLQPLVGPPADNKNQNGGNQSNEVSKNVNGKVQSEKENKNCISKLRDDGKLLTNNETAQSKNSSKNIIRGLTFIKDENDTSGIDKSKINESVNPEIDFKDEFNKYSSEASVDVSDDEEEVDDDDEEEEEFEEIEEIEIEDEESSEEISDEEEIEEKEEELSDSETTDTNTKSSVIMRRINSTEELTNAELMLKKTLDNIKAEISDSEYEEISSNSQKSEGSDEAELSEANDLPEDPIELSTTKNDVDVESTIVLTLPKRKSTEIEGEENAVTQSTSKTIRLKDSKVLKVRVTEPEVVVHKKKESRKRFSIVAEYVQQFEGDSLNHERRNSKTKQQESLKITRDQSPVNERERTARRLLAEGRVSSYDEAEIAASLIGLKFQDDEAIHAAQECTSVESAIAFLQQECELCTGRFAVSQMISMLKCIHRCCNDCAKNYFTIQISDRNIMDAVCPFCKEPDLKDATEDEVLEYFSILDIQLKSLLDPPIHELFQRKLRDRTLMQDPNFKWCAQCSSGFYANPNQKRLICPDCRSVTCAFCRKPWEKQHEGITCEQFEEWKNENDPDNQAIGLAKHLADNGIDCPKCKFRYSLSRGGCMHFTCNQCKYEFCCGCGKAFMMGAKCTVSPYCAKLGLHSHHPRNCLFYLRDKEPAQLQSLLKGHGIEFNTENSSGDRKCKVQLQKETPTGVIDAVCNSDVVENHAGLCRIHYIEYLVRKIRLSKLEPLSLFSIDDLETCIKRAGLNLPANWYRRDPEDYRRDLAEHYVEYLAGLVLKSKLDPVTIFDLNETKQELRRRGKVPPIKAQEMSEQDYLRTCIQVVQKEIPLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HP16</accession>
    <name>A0A8J2HP16_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Elongation of very long chain fatty acids protein</fullName>
            <ecNumber evidence="10">2.3.1.199</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Very-long-chain 3-oxoacyl-CoA synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HICCMSTLAB_LOCUS10970</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a very-long-chain acyl-CoA + malonyl-CoA + H(+) = a very-long-chain 3-oxoacyl-CoA + CO2 + CoA</text>
            <dbReference type="Rhea" id="RHEA:32727"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:90725"/>
            <dbReference type="ChEBI" id="CHEBI:90736"/>
            <dbReference type="EC" id="2.3.1.199"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the ELO family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.199" evidence="10"/>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5102348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HP16"/>
    <dbReference type="OrthoDB" id="434092at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009922">
        <property type="term" value="F:fatty acid elongase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034625">
        <property type="term" value="P:fatty acid elongation, monounsaturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034626">
        <property type="term" value="P:fatty acid elongation, polyunsaturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019367">
        <property type="term" value="P:fatty acid elongation, saturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030148">
        <property type="term" value="P:sphingolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042761">
        <property type="term" value="P:very long-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030457">
        <property type="entry name" value="ELO_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002076">
        <property type="entry name" value="ELO_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11157:SF28">
        <property type="entry name" value="ELONGATION OF VERY LONG CHAIN FATTY ACIDS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11157">
        <property type="entry name" value="FATTY ACID ACYL TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01151">
        <property type="entry name" value="ELO"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01188">
        <property type="entry name" value="ELO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="5 10" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2 10" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="7 10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="42"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="82"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="132"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="162"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="186"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="220"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="250"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="295"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="328"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="369"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="412"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="515"/>
            <end position="539"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAG5102348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="567" mass="66919" checksum="D787F0716691E19B" modified="2022-05-25" version="1">MTISIFAGFTVEKHQKTYNMPGIVDWYRDLMQNKIDKRTEDWFLVTGPGPLLMIFVTYIYFSTSAGPKYMRDKKPYSLKNVLIIYNFIQVVLSFTLVYEGLASGWWNDYSFGCQPVDRSMSPKALRMARAVWLYYICKLIELADTVFFVLRKKQRQISFLHVWHHSIMIVTAWIGVRFFPGGHATLLGVINSFIHILMYSYYMLSAFGPHMEKYLWWKRHLTTLQLVQFFLIFIHNFQQFRLGCDFPKTLTGLLCFNAGFFTYLFGSFYVKTYLSSRVSEKKFTELQFYCNSTVFFFRAIQLFIKLNFMHTIYVTIINNINPRTKDWFLMSSPWPGFAILAFYLYFVFTLGPRLMANRPPMKLDRIMQIYNVIQIYLSGYLVYKALSLAWLNEYSFVCQPVDYSNSPRAVEIAGAVWFYFMVKLFDLMDTVFFVLRKKQNQVSFLHVYHHAGMVMGAWGLVNSFVHVIMYSHYLATSLKISKPWWKKYITQLQLTQFFLLLIHFSQLIWTKDCGFPLWPAAIFIPQNLFMMVLFGDFYYKAYIKKPTPKINQNGITQNITNGSTKSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HP91</accession>
    <name>A0A8J2HP91_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS11461</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5103341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HP91"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5103341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="104" mass="12082" checksum="3F9F1724E694FECD" modified="2022-05-25" version="1">MQQGSTSNGSLNVSKIPEHKINSEHYENRTCLLLYYFDELGRILVIKSRLQLDKKLKNSLSFLVKILKPIHTNEQSKDPIELDLIAERHFFIAFKDEGKFCSKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HQ28</accession>
    <name>A0A8J2HQ28_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to Neurochondrin: Neurochondrin homolog (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS12287</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the neurochondrin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5106492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HQ28"/>
    <dbReference type="OrthoDB" id="8186546at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030425">
        <property type="term" value="C:dendrite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031175">
        <property type="term" value="P:neuron projection development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048168">
        <property type="term" value="P:regulation of neuronal synaptic plasticity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.710">
        <property type="entry name" value="Haloacid dehalogenase hydrolase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011950">
        <property type="entry name" value="HAD-SF_hydro_IA_CTE7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008709">
        <property type="entry name" value="Neurochondrin"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02253">
        <property type="entry name" value="CTE7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01549">
        <property type="entry name" value="HAD-SF-IA-v1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13109">
        <property type="entry name" value="NEUROCHONDRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13109:SF7">
        <property type="entry name" value="NEUROCHONDRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05536">
        <property type="entry name" value="Neurochondrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="997"/>
            <end position="1016"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5106492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="1016" mass="114258" checksum="637356A8BBC2069E" modified="2022-05-25" version="1">MLFVAAQRQNTLKRTKPTTGASLRAQYCLDLDFIDQFSSNQDSQETMAAYGVRNAAITTILFDLDNTLIETRKGDSLACKKMSIPKNVEECVNALKKATSDSAKFGAVFMVTKLVKSDDCRAEDYKLIFEAIGSKFLRRLMVSNDVPAGCPPDIYRSIAFSILTAFCNEPELAQHPDMISHVPALLEIISQITDDTSDDMLIIVSQAYTCLQNIAQFPAGQKALLEQGAIPKMCEIYSEQSFQTDQALNILVTLVNHLGPEAWDPVDTAPFHAILNKIAVDFETDHSERKFELCGILQALIASCRKDAVVDTCKEETWPQSLYKGLFDILGSKIGKNQRDPALKLASTVLELFGAEWALMDEEKPKAFFLLLIQLACIEVRMQLEGKQLKSVLQNADLITACFVILEVSLQYITTDQLDLEQKEKQSLYTALKGAFSAVIGLLTSVSKMKELTDIKEKVFVCAMVRVLAAWLVQDTSAMRPQVYAVLPYMLTVAKDTFYAFRNRKLAEKLKANKPEDSSSSSEPVVHDPLSEVDVLRVLLPALCHLAVEEDARKIMLKHKQEEILFDCLSYHWTVVQNKKPPVPRSERLKAIKEPQKEIEPRILEEMKDSRAAMVSICNVLMNITVLEAKLVEQSQTFIALLKFIFDNLPIVKQTSENLVLHGHLAVLGLLLLKQQAKLAKKNDYSITGFIRATIRFLWDAYIVDESSNSSELVVSISYKEHWMEIMELWFLGMQTMASVLQQIPWLAEFAIESGWVQGIIDLLKKVKIGSLPPNVKSAYEDLLCHLVKADSKLAEELTTQYNVPHEASTKITSSYLKHFRNCPDNQAYDLDTWRTSLWSKALGEKYSCIADKVYARWLYLRYRYLALTPDTQSMLMELRKKYALGLITNGSSNAQWEKIRQLDISRYFDLILVSGDLPWEKPESRIFHEACRILGALPSNCIMVGDKLETDILGGVESGLGGTVWLPISDKTRLSADDPKPDYTIKRVTDLISILNRRPGPPELEDSSSNASDGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HQH4</accession>
    <name>A0A8J2HQH4_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Similar to NOVA1: RNA-binding protein Nova-1 (Macaca fascicularis)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HICCMSTLAB_LOCUS12452</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5106822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HQH4"/>
    <dbReference type="OrthoDB" id="441329at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd22435">
        <property type="entry name" value="KH-I_NOVA_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22436">
        <property type="entry name" value="KH-I_NOVA_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09031">
        <property type="entry name" value="KH-I_NOVA_rpt3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.10:FF:000022">
        <property type="entry name" value="RNA-binding protein Nova-1 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047275">
        <property type="entry name" value="KH-I_NOVA_rpt1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047276">
        <property type="entry name" value="KH-I_NOVA_rpt2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047274">
        <property type="entry name" value="KH-I_NOVA_rpt3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10288">
        <property type="entry name" value="KH DOMAIN CONTAINING RNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00013">
        <property type="entry name" value="KH_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50084">
        <property type="entry name" value="KH_TYPE_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="K Homology" evidence="9">
        <location>
            <begin position="44"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="9">
        <location>
            <begin position="139"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="9">
        <location>
            <begin position="425"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAG5106822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="515" mass="54178" checksum="B58F4FF62C5FF871" modified="2022-05-25" version="1">MAADSGMETCPSPEIADSRKRPLDCDAENGATKRSHYGTAGGDGMYHLKVLVPGVAAGAIIGKGGETIAQLQKDTDARVKMSKARDFYPGTSERVCLITGSVDSIMAVMDFIMEKIREKPDLTSKITVDFDSGKATAERDKQVKILVPNSTAGMIIGKAGNYIKQIKEDSGSYVQISQKAKDLSLQERCITVIGEKENNRSALLMILAKIADDPQSGTCLNVSYADVSGPVANYNPTGSPYAQAPGTAPTYPTPAGLNTVSLLNGAGLSLNLNLGAAITAGTAPVTTQLLEHIKLNLRSTGFSEAAATEILTAIATLAKYNILGMGIGGMPSVSYLGNPIDSTTSANGSNNNGGVFGPIGTVPTLGSTSPTPRNTLERYEAFDPFRQNNTAAGAIHLNNNSFGLGTNQLSLVSKSPTQVDTNSKETKKVDIEIPEVIVGAILGPGGRALIEIQQLSGANIQISKKGMFAPGTRNRIVTITGFPNAIGIAQYLIEQRINEEEAKRARHNVIAGMIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HQI6</accession>
    <name>A0A8J2HQI6_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Serine/threonine-protein kinase TOR</fullName>
            <ecNumber evidence="11">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">HICCMSTLAB_LOCUS13349</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the PI3/PI4-kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="11"/>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5108662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2250022at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031931">
        <property type="term" value="C:TORC1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031932">
        <property type="term" value="C:TORC2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044877">
        <property type="term" value="F:protein-containing complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016242">
        <property type="term" value="P:negative regulation of macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010605">
        <property type="term" value="P:negative regulation of macromolecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045930">
        <property type="term" value="P:negative regulation of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045787">
        <property type="term" value="P:positive regulation of cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051094">
        <property type="term" value="P:positive regulation of developmental process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051240">
        <property type="term" value="P:positive regulation of multicellular organismal process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000243">
        <property type="term" value="P:positive regulation of reproductive process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008361">
        <property type="term" value="P:regulation of cell size"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051896">
        <property type="term" value="P:regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038202">
        <property type="term" value="P:TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05169">
        <property type="entry name" value="PIKKc_TOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000060">
        <property type="entry name" value="Serine/threonine-protein kinase mTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000094">
        <property type="entry name" value="Serine/threonine-protein kinase mTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1070.11:FF:000007">
        <property type="entry name" value="Serine/threonine-protein kinase TOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.150:FF:000001">
        <property type="entry name" value="Serine/threonine-protein kinase TOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1010.10:FF:000004">
        <property type="entry name" value="Serine/threonine-protein kinase TOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.150">
        <property type="entry name" value="FKBP12-rapamycin binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1070.11">
        <property type="entry name" value="Phosphatidylinositol 3-/4-kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1010.10">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050517">
        <property type="entry name" value="DDR_Repair_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003152">
        <property type="entry name" value="FATC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009076">
        <property type="entry name" value="FRB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036738">
        <property type="entry name" value="FRB_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057564">
        <property type="entry name" value="HEAT_ATR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024585">
        <property type="entry name" value="mTOR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000403">
        <property type="entry name" value="PI3/4_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036940">
        <property type="entry name" value="PI3/4_kinase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018936">
        <property type="entry name" value="PI3/4_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003151">
        <property type="entry name" value="PIK-rel_kinase_FAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014009">
        <property type="entry name" value="PIK_FAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026683">
        <property type="entry name" value="TOR_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11139">
        <property type="entry name" value="ATAXIA TELANGIECTASIA MUTATED ATM -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11139:SF9">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE MTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02259">
        <property type="entry name" value="FAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02260">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08771">
        <property type="entry name" value="FRB_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23593">
        <property type="entry name" value="HEAT_ATR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11865">
        <property type="entry name" value="mTOR_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00454">
        <property type="entry name" value="PI3_PI4_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01346">
        <property type="entry name" value="DUF3385"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01343">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00146">
        <property type="entry name" value="PI3Kc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01345">
        <property type="entry name" value="Rapamycin_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47212">
        <property type="entry name" value="FKBP12-rapamycin-binding domain of FKBP-rapamycin-associated protein (FRAP)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51189">
        <property type="entry name" value="FAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51190">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00915">
        <property type="entry name" value="PI3_4_KINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00916">
        <property type="entry name" value="PI3_4_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50290">
        <property type="entry name" value="PI3_4_KINASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5 11 16" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="11" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="2 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="FAT" evidence="14">
        <location>
            <begin position="1330"/>
            <end position="1887"/>
        </location>
    </feature>
    <feature type="domain" description="PI3K/PI4K catalytic" evidence="13">
        <location>
            <begin position="2061"/>
            <end position="2375"/>
        </location>
    </feature>
    <feature type="domain" description="FATC" evidence="15">
        <location>
            <begin position="2416"/>
            <end position="2448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="2343"/>
            <end position="2365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="2349"/>
            <end position="2358"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="16">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU364109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CAG5108662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="2448" mass="279655" checksum="4023EFA1C1AB89FF" modified="2022-05-25" version="1" fragment="single">NIKMTSSLVQQFVQRLKSRHEDVRNKAARDLCHYVKTELRESSQEEITAFMDEFNHHIIEMVNGSDMNEKKGGILAIVCLIGADVGNINTRTIRFANYLRSLLPSTDVGVMELTAKTVGKLALVSGTYTAEYVEFEVKRAFEWLGGDRNEGKRHAAVLVLRELAVSMPTYFFQQVTQFFDLIFNAVRDPKAVIREGAVEALRAALVVTAQRETTKQMLKSQWYKQCYDEVVAGFEEVYSKERGYNRDDRIHGSLLVLNELFRCSNIQWERDYESLMERLNCPTQQADNDILALMPRLKTIIVSKWSGCPSGDNFHHTQQSLHLLHESAACRQLMQERLDDFYNDVMNQRHSKNPHIQHSLMTCLPRLVAFNTEKFNKEYRRETMNYLLMTLRGREKDRHAAFMTIGLIAVAIGDSIKPYLSKIMEVIKMSLPSKETPSKKRSAPLEPAVFICITLLGFAVKSAISADIRDLLDSMLATGLSPILTTSLRELAQNVPSLKPDISQGLLRMLSQVLMHKPLRHPGAPWTATSPIITTPNEPTDVPSTVLALRTLGTFNFDGNPLLQFVRRCADHFLTSDQSEVRLEAVRTCSRLLRLALNQPGPTVTKTVHTIIEKLVIVGITDMESDVRISVFTSLDSSFDIYLAQSENLSSLFIAMNDEVFDIREIVIRTTGRLSIINPAHIMPSLRKCLIQFLTELEHSGMGRNKEQATRMLDHLVVGAPRLIRPYMEPILKVLVPKLKEPEANPGVVLAILRAVGDLAEVNGAEMQQWMPELLSILLEMLVDASSPEKRGVALWVLGQLVGSTGHVVKPYMQYPTLLEVLINFLKTEQQPIIRRETIRVLGLLGALDPYKHKMSLGQIDSQLDTLTSIMDSKSELENNQDLTTSEMLVNMSSSSLEEFYPAIAIATLMRIIRDPTLAQHHTMVVQAVTFIFKSLGIKCVPYISQVVPSFLNVVRTADVNFREYLFQQLSVLIAIVKQHIRNYLDDTFNLIKEFWTINSPLQSTLINLVQNIAIALGAEFKVYLPHLMPQILKVLYSDNSKDRTVTVKLLEALQTFGNNLDNYIHMVLPPIVNLFHAPDCPIVVNRVALETVDQLADTLDFSEYVSRIVRAAVRTIDLCPELRNTTMDMLCSLVMQLGKKYQYFIPLVQSYMTKHKISNSQYDVLVDKILTETSVPDGDDYLLMRHRHPRNRNRDLSLASSDITTIKYLHVSASNLQKAWTASRRVSKDDWLEWLKSLSIGLLKESPSPALRSCWALAQTYSQLPRDLFNAAFVSCWTELNETYRAELIQTLQQALMVPDIPEITQTILNLAEFMDHCDKGPLPIDYKILGERAMNCRAYAKALHYKEDEFHKSRNGAVFESLISINNKLQQKEAAEGLLEYVMNQNNQQDLKVQVRWYEKLHNWDKALDLYSERLETDPSDVESTLGKMRCLEALGEWGQLHEVATREWSNQIDDAKQRMARMAAAAAWGLGQWESMEKYVALVPKDTQDGAFYRAVLAIHNEQYNVAHQLIDNARDLLDTELTAMAGESYQRAYNAMVEVQKLAELEEVIQFKLVPERRATIKSMWWERLQGGQRIVEDWQKIIQVHTLVVSPQDDMYTWLKYASLCRKSGNLKLDHKTLVMLLGSDPSKAPKDPLPTTHPQVTFAYCKHLWVANDREDAYNQLLHFVINSVKSLSNSPSKLDEEQLHQHEAHRRLLARCYLKLGEWLESLQGINEHSIPAVLSYYAAATEYDSSWYKAWHAFAYTNFESVLFYKHQQEETVPEANGVRNQSIPSSQYISHFTVPAVEGFFKSINLSHGNSLQDTLRLLTLWFDYGQWPEVYDAIIEGIRMIEINTWLQVIPQLIARIDTPRALVSRCIHHLLIDIGKSHPQALVYPLTVASKSASLARKTAANKILKNMCEHSPTLVSQAIMISDELIRVAIIWHELWHEGLEEASRLYFGEKNVVGMFETLEPLHTMLERGAQTLKETSFIQAYGRDLMEAQEWCHRYKVSNNVRDLNQAWDLYYHVFRRISRQLPQLTSLELQYVSPKLLLCRDLELAVPGSYVPGQSIVRIASIHSSMQVITSKQRPRKLCIKGSNGKDYMFLLKGHEDLRQDERVMQLFGLVNTLLLHDPDTFRRNLTIQRYAVIPLSTNSGLIGWVPHCDTLHTLIRDYRDKKKILLNIEHRIMLRMAPDYDHLMLMQKVEVFEHALEHTHGDDLARLLWLKSPSSETWFDRRTNYTRSLAVMSMVGYILGLGDRHPSNLMLDRLSGKILHIDFGDCFEVAMTREKFPEKIPFRLTRMLINAMEVTGIEGTYRKTCESVMSVLHRNKDSLMAVLEAFVYDPLLNWRLIDNNATKSKRSDAQSMNTSSSQEHGDILDSLNSTLPKKGALSAESTNADVNQPEALNKKALAITNRVRDKLTGRDFSHEETLNVKRQVQLLIQQATNNENLCQCYIGWCPFW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HQJ5</accession>
    <name>A0A8J2HQJ5_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Similar to mthl5: Probable G-protein coupled receptor Mth-like 5 (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HICCMSTLAB_LOCUS13109</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5108181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HQJ5"/>
    <dbReference type="OrthoDB" id="6339480at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007166">
        <property type="term" value="P:cell surface receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017981">
        <property type="entry name" value="GPCR_2-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052808">
        <property type="entry name" value="GPCR_Mth-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46953">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR MTH-LIKE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46953:SF2">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR MTH-LIKE 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50261">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035285577" evidence="6">
        <location>
            <begin position="20"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="200"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="225"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="263"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="305"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="347"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="392"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="418"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 2" evidence="7">
        <location>
            <begin position="194"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG5108181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="479" mass="55172" checksum="3E48C41DA0931F11" modified="2022-05-25" version="1">MYFLLLIYFFECLYNFVNGSSTIKPQNINELIKIGKCCDLNEIILDDKCALLTETNETTTWKPDFIDDNFPVRKKQYLNFQFKIGLPNCRNTEHQWHVYYNPYNQSQDLLAILPSGSLRHILHDRWNNTQNQKNELHNYEIDDDSITVESLYFDYSFGHYCADKAVLSKNSLITTYAMICVPAVAWTDSKYLIQRIVDPITRAFGISCYLLVAIVYFVLPQLRDLVGNIITSMTMCLVVYQTASTVKIITANASHVSFFIADSVAYVSLLATFFWLNSFGYFVWSTFRSRNIFLRVSDGQKYCYYSSYVWGSTATIFGTAIFAHFTLETNKVIVGDGINYAQESVGWLAMSVIFASIALTIIVNICFIVMTINTIKQTRTYGRIHHKIKYSFRMFTLLFGILSLGWLSFIISHLKYDSLIYCHIIVNILQALFVVYVCIFEQKRVLFLLSKTCNCCNSVQNTTDDIDWGEEMTAINAGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HR48</accession>
    <name>A0A8J2HR48_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS13366</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5108696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HR48"/>
    <dbReference type="OrthoDB" id="8193942at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="137"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="481"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="508"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="602"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="84"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="515"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="602"/>
            <end position="616"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5108696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="727" mass="84186" checksum="CC7EF99B07F86F59" modified="2022-05-25" version="1">MSSVIKSIKYNYSNDEISPESIDVSDDDDFNFKYVPSNQFKYIVKDVRRQRTKNDEERVWTSFVNRQDQKSNYYQECYHGVDAKQLLRENLQEVDKELRKFDADSEQTERLTVCTNDYKRSNLPSREEKKSLKFDYQVENDEDNDSESSSTLRAVQKEDEDELIYERSPVSQLDFKSKTTKLRYEHTIRHHHERPCTFYRDCNCRDCTSTPELISQNGSNQYSSHVVRIDPVVAHKILGVQAKISELLDEISYRLCRIPQPDGDIDLKRRQQRVMEFAIRFSRNYLYELRRQMSDVQRHVRVMSPSARRPTKRVLSLHMQALEQKLCSIHQLLLNALSAYCKHIPSSILKGHPGKLKEILQVVIDLRDVCSKINLTAELFGAGDTAPLPLGKDTQKRCYAILSKLRLTSDHESAYNHTAPTLIGTSASEAKRRNRLDNRKHNQNRFSMYCVDSKYSKCLRNRRPVTVGVCPRTAVGRLRLNNPASGPIEPPHPNIGMQKPRREVLKRNRARTRAYQKEDDIRTRQSETHTKSSKHNVNSKKSTEIVIKNKQLSSLIPIITDLISLAAKKQKNSSLKDAITMEALLEFLHEYLAEKMKSSRKSSITSESLGSASKSSETQRTSKTQSSREFESNREFVNSALSNDKKSGLTQLKVSQDSADRLLKYRDEYQRLCSLSPMYTSNSLNKPWDVVSWISDKLIDELIVEISKELQMDDLIKKLVDLEFQDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HRC1</accession>
    <name>A0A8J2HRC1_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">HICCMSTLAB_LOCUS11833</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5104100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HRC1"/>
    <dbReference type="OrthoDB" id="8693905at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000947">
        <property type="entry name" value="serine/threonine-protein kinase OSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000043">
        <property type="entry name" value="serine/threonine-protein kinase OSR1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024678">
        <property type="entry name" value="Kinase_OSR1/WNK_CCT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050629">
        <property type="entry name" value="STE20/SPS1-PAK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48012:SF16">
        <property type="entry name" value="NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48012">
        <property type="entry name" value="STERILE20-LIKE KINASE, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12202">
        <property type="entry name" value="OSR1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="174"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="118"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="447"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="118"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="500"/>
            <end position="512"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CAG5104100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="646" mass="71649" checksum="0D2C83E53E071BCC" modified="2022-05-25" version="1">MSVVGKICSDDGLKITSTTTGELFLDQQDEIYNTIESKNNSIISPDVIPSCSPGIFRQKSFRTSSTEAEVTKISSENLGIPLSPGNHHQCSHISPKEHNSVIITNHSVSNNKNYKNINNNNNNNTNNNNNNNNNNNNNNTRKNNKNTSSNLTLSGGGFRNWGLKNTGKHSRLTTVLSNKMASTSTTAVVQGWPNTKDDYELKEVIEKCAIKRINLEKWNTSMDELLKEIQAMSSCNHENVVTYYTSFVVKEELWLVLRLLEGGSLLDIIKHKTRTTNCKHGVFDEATIATVLREIADFGVSAWLATGRDLSRQKVRHTFVGTPCWMAPEVMEQDHGYDFKADIWSLGITAIEMASGTAPYHKYPPMKVLMLTLQNDPPTLDTAADEKDQYKAYGKTFRKMIVDCLQKDPTKRPSATELLKHPFFKKAKDKKYLQQTLVAIGPSLETRVQKASKRQPGTSGRLHRTVTGEWVWSSEEEDSGASSGDEGKETLPVNTIDNVSSEEEAADQEDSEGQVRAAMSRVALQSAEQNIPINLVLRLRRPDTQFSFDNDPFFLLPNQNQKRELNDIRFEFAVGVDSAEGIAAELVGAGLVDGKDIVVIAANLQKLIDSAGQLRTVTFSLNSGHAPNEIPDDKALIGFAQISITD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HRD6</accession>
    <name>A0A8J2HRD6_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Similar to At3g55350: Protein ALP1-like (Arabidopsis thaliana)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HICCMSTLAB_LOCUS11803</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the HARBI1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5104039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HRD6"/>
    <dbReference type="OrthoDB" id="2668416at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045249">
        <property type="entry name" value="HARBI1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027806">
        <property type="entry name" value="HARBI1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22930">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22930:SF85">
        <property type="entry name" value="GH03217P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13359">
        <property type="entry name" value="DDE_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE Tnp4" evidence="8">
        <location>
            <begin position="154"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAG5104039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="356" mass="41005" checksum="37AF51AFD05BC811" modified="2022-05-25" version="1">MEAMLANYGTTIQLIDNDLARSNEEFKKQMEMSNENKNKRMKSILKTTLTMMKSPGNVQETPDDSSGKTWWEQFKDSGYPDDQCFEFFRCSRVPVDKQIAAVLSKISNRDTFGRLSAKFSLYKPTLIGIIDTLHIPICNAYGMADAFTNSKNYYSFRDVSIRFPGARTDIEILQDSNIYRLHEKVIPPETQSINGMEIPYYVIGPRSYPLLSWLLTEYPMATTNSDLLFNSHIEAASQLRKTAIERMRARFDILNYPIDVNIGILPQLIGCCFALHNICERHGDFLSDERIKSSLIVASNYEQPEKVPYTDKNMCLKGVNQRDCIRNYFVRLDDIDQSTFGYMDYESIDFLTEEVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HU25</accession>
    <name>A0A8J2HU25_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Similar to NTM: Neurotrimin (Bos taurus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HICCMSTLAB_LOCUS13604</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5108968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HU25"/>
    <dbReference type="OrthoDB" id="10012075at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000328">
        <property type="entry name" value="CLUMA_CG000981, isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000032">
        <property type="entry name" value="palladin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051170">
        <property type="entry name" value="Neural/epithelial_adhesion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12231">
        <property type="entry name" value="CTX-RELATED TYPE I TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12231:SF105">
        <property type="entry name" value="LACHESIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Ig-like" evidence="9">
        <location>
            <begin position="74"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="9">
        <location>
            <begin position="185"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAG5108968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="317" mass="34919" checksum="E05D7A4D4FF4C6D2" modified="2022-05-25" version="1">MGSGAGGLVPAVAPVAAPVHGVIGSNQVMDEGVNCTWRLHIRHLKKSDEGCYMCQINTSPMISELGCLSILVPPDIVYGDETSKDLSVTEGENVTLNCQATGTPKPRVSWRREDGQHILIRNSTSFSSSYSGKSYNFKKVEIYNESKLHFYRVDRQQMGVYMCIATNDVPPTVSKRVALEVNFAPTVQVQSQLLGAPLGTRVQMDCSIEAHPNTINFWEKNRTEMLVDGPKYEIHEERSGYQVLTALVIKKFTEQDEGIYVCTASNILGKAEGTSRLYRLAEAARGSRSSSNTRPTSLFFISLGAISLFSHSLCSLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MCL3</accession>
    <name>A0A8J2MCL3_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS3211</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5081177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MCL3"/>
    <dbReference type="OrthoDB" id="6070751at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5081177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="126" mass="14300" checksum="5BFC479EFEEF0900" modified="2022-05-25" version="1">MNIFRGDQLMPSERYSVQPRGNVVQLTLKQSQKDDTGHYSLVAKKLTTNYSDSNDISIEGVRKKIRMNIRDASDDPEEGEPPIFVRRLTDLAVKVGTRTRFLVEIRSSSSPKTVNKIPGRRSLKSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2ME47</accession>
    <name>A0A8J2ME47_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">Serine/threonine-protein kinase PRP4 homolog</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="21">PRP4 pre-mRNA-processing factor 4 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="27" type="ORF">HICCMSTLAB_LOCUS4172</name>
    </gene>
    <organism evidence="27 28">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="27" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="24">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="24">
            <dbReference type="Rhea" id="RHEA:17990"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="23">
            <dbReference type="Rhea" id="RHEA:46609"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="22">Interacts with CLK1 C-terminus. Associates with the U5 snRNP and NCOR1 deacetylase complexes. Identified in the spliceosome C complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Centromere</location>
            <location evidence="2">Kinetochore</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="19">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="27">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5084679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2ME47"/>
    <dbReference type="OrthoDB" id="3967at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14135">
        <property type="entry name" value="STKc_PRP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000078">
        <property type="entry name" value="Serine/threonine-protein kinase PRP4 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000123">
        <property type="entry name" value="serine/threonine-protein kinase PRP4 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050494">
        <property type="entry name" value="Ser_Thr_dual-spec_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044092">
        <property type="entry name" value="STKc_PRP4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24058">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24058:SF103">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE PRP4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="16" id="KW-0007">Acetylation</keyword>
    <keyword evidence="14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="5" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="12 27" id="KW-0418">Kinase</keyword>
    <keyword evidence="13" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="8" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="17" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="28" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="10" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <keyword evidence="15" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="Protein kinase" evidence="26">
        <location>
            <begin position="650"/>
            <end position="968"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="25">
        <location>
            <begin position="27"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="25">
        <location>
            <begin position="157"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="25">
        <location>
            <begin position="519"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="25">
        <location>
            <begin position="28"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="25">
        <location>
            <begin position="44"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="25">
        <location>
            <begin position="60"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="25">
        <location>
            <begin position="160"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="25">
        <location>
            <begin position="191"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="25">
        <location>
            <begin position="224"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="25">
        <location>
            <begin position="403"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="25">
        <location>
            <begin position="422"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="25">
        <location>
            <begin position="464"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="25">
        <location>
            <begin position="519"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="25">
        <location>
            <begin position="563"/>
            <end position="590"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00031858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00046964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00048659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00048977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="EMBL" id="CAG5084679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="972" mass="113382" checksum="F251B3D05BF773D7" modified="2022-05-25" version="1">MGSSDLEYIDSKQDIHSIDEHADVFEQKKKKKRKHKHHKHKKDKIVDKEKIDVKVDRQDRKKHKKHKKLQKDKEVENNGIAGEKVPVKNDIKESGINGKVVNSVMEIPSTESEGENLVDLDSDEVDCTIIEDDVDLEELMKQKERLQACLVQYLSDESEKDDKRFNREEITKKTPDVILVEDDSGDDIIAKQKRHRSRSGSRERKKNIKSTDRIVTDITRVKKSKQDVGEKRKEGDRRRDETTKHNDESKKSDKLRKVIEKKEVTRKDDLRKRIDEDRRKEVGKRDELRKRDHDIKEDERKREDYRSSKSRNDSNNRDMKGNSKNLKPAENRNCHSGRDRDARSREPVVSKDGHSSRDKGDNWDKHNNRDRYTSNRDTASNRDSRNHDKTCERSRRSRSPARYRNDRDRNDRYRRSRSLSRNRRDRDRHGRNDRDREKNGKRERGDKYKDSLSEGLKVERSDSSSEDDLKDIDIEEEEDEETIIERRRKQREELLKRLGGPTEDSNMSTDVIVNDNPVSTEQLSSSSKNVEAVNNSDSNSESHTPPLPDQNKLQLLAKKRKSRFDEPPTKKKSENQEEVKTNEKNDDKINVKKASEWDMFADVDNVGDFNSPTVEGNRVGGHENPSLTDNWDDAEGYYRVRIGETLDSRYTVYGYTGQGVFSNVVRARDTTRGGMDVAVKIIRNNEIMHRTGLKELEILRKLNDEDSEDRFHCLRLYRHFFHKNHLCMVFEPLSMNLREVLKKYGKDVGLHVKAVRSYSRQLFLALKLLSKSNILHGDIKPDNILVSENKIVLKLCDFGSACYAHENENTPYLVSRFYRAPEIILGIKYDCAIDMWSVGCTIYELYTGKIMFSGKTNNQMLKFFMDLKGKMPNKLIRKGAFKDQHFDANCNFLYHEVDKVTEREKVVVMSTIPPTRDLGAELGGTSLSAEQKSRVSPVNQLKDLLERIITLDHTKRMKVKDALSHPFIQEKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MHZ6</accession>
    <name>A0A8J2MHZ6_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Exostosin-2</fullName>
            <ecNumber evidence="6">2.4.1.224</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">HICCMSTLAB_LOCUS6527</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
            <topology evidence="3">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus membrane</location>
            <topology evidence="2">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the glycosyltransferase 47 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="23">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.224" evidence="6"/>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5093016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MHZ6"/>
    <dbReference type="OrthoDB" id="5954868at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050508">
        <property type="term" value="F:glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015020">
        <property type="term" value="F:glucuronosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015012">
        <property type="term" value="P:heparan sulfate proteoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000035">
        <property type="entry name" value="Putative Exostosin-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004263">
        <property type="entry name" value="Exostosin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040911">
        <property type="entry name" value="Exostosin_GT47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015338">
        <property type="entry name" value="GT64_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48261">
        <property type="entry name" value="ACETYLGLUCOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48261:SF5">
        <property type="entry name" value="EXOSTOSIN GLYCOSYLTRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03016">
        <property type="entry name" value="Exostosin_GT47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09258">
        <property type="entry name" value="Glyco_transf_64"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="16" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="17" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="14" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="18" id="KW-0464">Manganese</keyword>
    <keyword evidence="15 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 20" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="domain" description="Exostosin GT47" evidence="21">
        <location>
            <begin position="99"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl transferase 64" evidence="22">
        <location>
            <begin position="439"/>
            <end position="657"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00069568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF03016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF09258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="CAG5093016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="661" mass="75408" checksum="86522DC5656B34D5" modified="2022-05-25" version="1">MTPYFLRKNHQLVSNYHRNIILSLFAIVTSVLTLTIIYHLFGYVNTSKEVIYSRISIDAETLASLPQVTVSRSLKSSPKNLTCTHFTCFNVYRCGQEGSKLLIYVYPLESFLDEDGTIINNLSREFLQILQAIIRSKFYTPDPYQACLFVPSIDTLNQNRLNVQAVGRALASLEFWNHGENHLIFNLVSGVFPDYNTSLDVDIGKAILAGAGFSTLTFRNNFDLSIPVFTFRNALVPGTESEGKHLIISAQININIAFEQDLQDINTNNEILILHPCLNHNPMSSSVRCKNSRVYKYPEVLNSGIFCMVIRSARYGQTVLMDSLAAGCIPVIISDSIVMPFGDLIDWKRAAVFVREVDILGVISTLKNISATRIEELKSQGQWLWNRYFNSVDAIVNTGLEIINDRIFPQESKDYNYWNSRFSSSPLFLPVTAPKTHGFTAVILTYDRVELLFSLITKIAQVPSLSKILVVWNNVKKDPPVSARWPKVNKSLQVIRTKENKLSNRFYPYDEIETEAVLSIDDDIVMLTADELEFAYEVWREFPDRIVGFPSRTHTWDNETQCWRYESEWTNVISMVLTGAAFHHKYWMYLYTTSMPGDIKSWVDAHMNCEDIAMNFLIANTTGKSPIKVTPKKKFRCPECTNTEMLSADLAHMAERTRYSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MID3</accession>
    <name>A0A8J2MID3_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS6805</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5093415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MID3"/>
    <dbReference type="OrthoDB" id="6509516at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579">
        <property type="entry name" value="F5/8 TYPE C DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579:SF1">
        <property type="entry name" value="F5_8 TYPE C DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="376"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="20"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5093415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="697" mass="80166" checksum="AFCE52AC015B60B0" modified="2022-05-25" version="1">MHFDIGEESKRSAFSGLSEAESRSYTKGKKENDAANNSGLCDKSLREDDLYKLKNTIMFEPSNLSVWQVLTMIMAIVVRFNLSDEIQQAIISLMKLAAGPQFKCLDTSKYLINKFFNPVSNAAQYVFYCPTCNNLLTNPLPITKNIKSEVTCDKCKKKYETSKKEGNFFVTVDLEPQLQNYLSTEYVRKQIQDKIENRSNTNAEHSISDVCDSDRYKADEFIQSKNDSDNVVLTLNVNLDGAPLFKSGKNSFWPIQCIINEIPQIMRHNFMLLAGLWYTSCEPKPEFMNLYLKSFITQIQKLTVTGLKVLVENGRVITYFVKIFSFPVDSVARPVLQNRLQFNGFYGCSWCYQRGQTSSRSMKYPLSSDTPRLRDHESYVKDVEKHKNDIKKLRKTKKNEKYTVFGIKGSSVLSSLSDFDCVWGFPHDYMHGVLLGVTRQLWNKWSKEFLSVDQRKLINARLTAIQPPNEIHRTPQILLKRKSWKATEWRSWLLFYSVPVLSGILRQDLLDSYKLLVKSIFKLLSVNLTENELLQCEMDLLKFVYDCQNLYGISFITFNVHSLLHIVDSVRKNGPSWATSTYAFENNIYNLKLQVSGPNGVLGQMAIRTLRSNNFQKVLATESNETCRQFSEGILNKKRPNVSKAVESDNGALLMDHVNEGQLENSAYSIVVVYFKKRCITVKYINKQEKLTTHLLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MJY6</accession>
    <name>A0A8J2MJY6_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Similar to PREB: Prolactin regulatory element-binding protein (Homo sapiens)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">HICCMSTLAB_LOCUS8179</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5096376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MJY6"/>
    <dbReference type="OrthoDB" id="2013972at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003400">
        <property type="term" value="P:regulation of COPII vesicle coating"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045260">
        <property type="entry name" value="Sec12-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23284">
        <property type="entry name" value="PROLACTIN REGULATORY ELEMENT BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23284:SF0">
        <property type="entry name" value="PROLACTIN REGULATORY ELEMENT-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <keyword evidence="3 11" id="KW-0853">WD repeat</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="412"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="187"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="219"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="118"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="121"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CAG5096376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="437" mass="48395" checksum="145F72EDFBADFBF8" modified="2022-05-25" version="1">MPSRRNNEGLLARVNFPLYTIQMLTNRHVLVGGGGGSSKTGVANGFEIFELSHDGSNFIAEEVTRHETGPSVVMNCASFNNSKKTWLVAGQESHCQLYNVVPRVVAVENGEVVAGANSNFKENDNSLRQRKLNEKKGNSSSNSNTEKVENIRDSNSNIKHKKLQLILKPSTSIQTDFSEPEPLQRIVRVSSNGKVMATGGLDGVIRLWKFPQFEKMYDLKAHTKEVDDIDFNINGKFVATIAKDNRAFVWNVVEGKKYKELSWVPPNGAKYLFKRLRFKIPNEKKSATQLYMLSNATSSKLPSYLQLWDVDQGIIIKSAPYKETLSAIAVSDDGKFVAVGTMFSGSIDIYIAFSLQKALHVSGAHSMFVTGLEFLPTTLDGPSITSNSETAVVSISVDNRICIHSIPFRHALPFWLVTLLIILSICGAFIFCSYMGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MK44</accession>
    <name>A0A8J2MK44_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS5051</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5088981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MK44"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5088981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="17" mass="1844" checksum="456DF4310C7370B8" modified="2022-05-25" version="1">MWVQSGPNKSPGHQPPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MKR7</accession>
    <name>A0A8J2MKR7_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS5595</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5090345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MKR7"/>
    <dbReference type="OrthoDB" id="7705557at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5090345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="276" mass="31250" checksum="90DC38ABA05B81FC" modified="2022-05-25" version="1">MGTIPIYCGKHAENKFIVVIKNNFSVSKIMSDRVKKYRALKKYMDNRSQPPNTPSLLIDNDHNTNDHDHNNLSSETIVNSVVNKENNYGAFVSDNESSLSDCVDDSYQSIYPAESEVIISNETDTDSSDSNNQSIAEENVKCEINNSSDIVFEGNLYSSVSSITIKQNYLSSNRPDNIILLKNNKVIIIDQLLTTKTNVEKTPKLNEIYILGRQMLNAGNLFDYPTPSKDVAIRLTELENDKIFQKLSYEDKCNSYISVKSSKNNQRKEEEISVHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MMM1</accession>
    <name>A0A8J2MMM1_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">GPN-loop GTPase 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HICCMSTLAB_LOCUS7548</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Small GTPase required for proper localization of RNA polymerase II (RNAPII). May act at an RNAP assembly step prior to nuclear import.</text>
    </comment>
    <comment type="function">
        <text evidence="7">Small GTPase required for proper nuclear import of RNA polymerase II and III (RNAPII and RNAPIII). May act at an RNAP assembly step prior to nuclear import.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Binds to RNA polymerase II (RNAPII).</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the GPN-loop GTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5095116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MMM1"/>
    <dbReference type="OrthoDB" id="5839at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17872">
        <property type="entry name" value="GPN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000616">
        <property type="entry name" value="GPN-loop GTPase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004130">
        <property type="entry name" value="Gpn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030228">
        <property type="entry name" value="Gpn3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21231:SF7">
        <property type="entry name" value="GPN-LOOP GTPASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21231">
        <property type="entry name" value="XPA-BINDING PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03029">
        <property type="entry name" value="ATP_bind_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG5095116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="274" mass="31086" checksum="5882F0639AFF39F7" modified="2022-05-25" version="1">MRYGQLVMGPAGSGKSTYCQAMQKHAADENKTIHVVNLDPAAEYFDYEPLVDIRELISVDDVMEDEEFKFGPNGGLIFCMEYLVENSQWLADELGDIDGDYIIFDCPGQLELYSHMSVIKKLIGMLESINFRLCGIFLLDSQFMVDSAKFLSGTMAALSVMVNLEIPHLSILSKTDLLSKKDKKQLDRYLEPDPYFLLADMEDDPWNQKYCRLTNAIGELIDSYSLVRFTPLDITDDESISDVRITIDNAIQFGEDEDVKTQDFGAEDEENEDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MN83</accession>
    <name>A0A8J2MN83_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Similar to WBP2: WW domain-binding protein 2 (Homo sapiens)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS442</name>
        <name evidence="4" type="ORF">HICCMSTLAB_LOCUS8241</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001114">
        <property type="protein sequence ID" value="CAG5073499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5096501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MN83"/>
    <dbReference type="OrthoDB" id="1259151at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031490">
        <property type="term" value="F:chromatin DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13214">
        <property type="entry name" value="PH-GRAM_WBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000338">
        <property type="entry name" value="Uncharacterized protein, isoform D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004182">
        <property type="entry name" value="GRAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044852">
        <property type="entry name" value="WBP2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31606">
        <property type="entry name" value="WW DOMAIN BINDING PROTEIN 2, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31606:SF1">
        <property type="entry name" value="WW DOMAIN BINDING PROTEIN 2, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02893">
        <property type="entry name" value="GRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GRAM" evidence="2">
        <location>
            <begin position="18"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="199"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="220"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5073499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG5096501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="261" mass="28734" checksum="E092606FD79DBB0C" modified="2022-05-25" version="1">MSLNTAHANNGVLLHAGECILLFCDNVTMEFHGQEQPEFIGSKKGRIYLTTHRMIFNAKDQNEKMKSFSFPFVTLSEVELEQPLFGANYIKGKCRAQPNGNWVGECKFKLHFKSGGAIEFGQAMLRAASMAQRSGPGYDAPPPYQPPTSNWYAAPPPAYQAAPSGYYGWMPPTNAFPDMPPANSVYMTDMPPPYPGINTAPMQGGNPQPVGSPAWANPEYNPGYQQTGYPQPPNYAQSAGYCNNYPQNPPPYSPQGSYKPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MNF1</accession>
    <name>A0A8J2MNF1_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similar to Trir: Telomerase RNA component interacting RNase (Mus musculus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS7119</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5093793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MNF1"/>
    <dbReference type="OrthoDB" id="1107506at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008409">
        <property type="term" value="F:5'-3' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038838">
        <property type="entry name" value="TRIR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34753">
        <property type="entry name" value="TELOMERASE RNA COMPONENT INTERACTING RNASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34753:SF1">
        <property type="entry name" value="TELOMERASE RNA COMPONENT INTERACTING RNASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="72"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="155"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="165"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="187"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5093793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="373" mass="42783" checksum="29456552762CF928" modified="2022-05-25" version="1">MDSRRYERGRNSDSPPEPPSPPSYSTQSRIASELPTQRSYKVNSRQSPHTEYSSKSSRSAQELSAATGPTITTTTTTSTTPSSSSSSSHEKRRRRHKRSRSSDRSRKYSRRRKSRSSSRPRSRSRGPRSRSRGARSRSRGVKSRSRERYRHSRSYSRSPSQRSRTYSRSRSRSRSRSRSRSNGQNNKIRDSGRDSRYRGNRHYRTSSHDSDYIPDIIDQQQHHHLGFPPSQIVQPIIPVQSNAFKNDGSFMEMFKKMQEKMQPAADKPATSLLEDKPVVPPPLMVGKRRGGRILKTGMVAKAKTEQVVEQPKDAWSLYMAEVKKYREVCCQEEDNTRPLINTATMAYGGIPKDIENYMSAPYDPRFPNTNQTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MNR1</accession>
    <name>A0A8J2MNR1_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Similar to Lrrc45: Leucine-rich repeat-containing protein 45 (Mus musculus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HICCMSTLAB_LOCUS10014</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
            <location evidence="1">Centrosome</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5100941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MNR1"/>
    <dbReference type="OrthoDB" id="8436363at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005814">
        <property type="term" value="C:centriole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097539">
        <property type="term" value="C:ciliary transition fiber"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051660">
        <property type="term" value="P:establishment of centrosome localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052116">
        <property type="entry name" value="Centro_Cilium_Assembly"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23170:SF2">
        <property type="entry name" value="CENTROSOMAL PROTEIN OF 83 KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23170">
        <property type="entry name" value="NY-REN-58 ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00368">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="303"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="370"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="505"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="571"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="312"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAG5100941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="707" mass="81742" checksum="711128554A6D31C7" modified="2022-05-25" version="1">MLSDYELFTQLCLKRGVFSPSEILDAMKIASSTGELRLPCQSIVIPVCEIISRVLISSSTIKSVDLSDCMLITKGLSKLLESLRDGTNITTLNLKGNNISGLIASQLGEIFQHNNTLKRLYLQWNNIGSEVEAFDKFCQGLAMNYNIEELDLRYNQITPHCADALMNLLKKNKALKVLNLEWNTLGLHGGQSLLNGIKDNNSITKLNLRGNCVPDSIVDLIDNVTLRNQSKKSITSSNITSKSTDKLTGNCFSKNDNCIMVLYERAHKLSLQDTENKLNDSESADEFKLKELGSNFRKKRLRRKKNSKSDKLLNSNSDSDSDSSFKINYNSDKGSKTEFNKIMELNKILHDRSETINVLTKQINTKDEEIKSSNELVEKLRYEIDEWKRKFDEIVEEKKREVQELEEKHKKIEEDLKKNCKTIEDKYNICLLKNKDWEEKVRYYEKNIHKSSLEVIALREKWMSKSKDYEDIIEIKNTEVHKIRREFKERDNKYKIEVNILKSTLKETTTALEDCQDQLQKSRNELREMASSLATFRAKVDELEGIDCKYGKVVEVCQRIKDEKFGVEEKLNDAQRIIAGLKKRVQSLESELVDPQRKYDLLKGQLDEERDKSARLKQELEDERMRIRDQDCQLQKMSQQVTVMSGQINDIQKNYAEELRERDKDIKQLKEIIAGKEKEFNDLKAEEAQRAGHLHAAFNKYLSSIGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MQD9</accession>
    <name>A0A8J2MQD9_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Chitin-binding type-2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HICCMSTLAB_LOCUS10481</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5101579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MQD9"/>
    <dbReference type="OrthoDB" id="6020543at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.140.10">
        <property type="entry name" value="Chitin binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002557">
        <property type="entry name" value="Chitin-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036508">
        <property type="entry name" value="Chitin-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01607">
        <property type="entry name" value="CBM_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00494">
        <property type="entry name" value="ChtBD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57625">
        <property type="entry name" value="Invertebrate chitin-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50940">
        <property type="entry name" value="CHIT_BIND_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035214301" description="Chitin-binding type-2 domain-containing protein" evidence="2">
        <location>
            <begin position="18"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="3">
        <location>
            <begin position="21"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="80"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG5101579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="187" mass="20778" checksum="C2AD1DF48947F85F" modified="2022-05-25" version="1">MKFLVLLMIGLLDATYASRCIGYCDIFSDLLAHEDCDKYCECTLFGDPIEYSCEHGLHFSFEFQDCVHPSLAGCRDVSEPSVTTPAPTRPPSTSVPVTPSPPVDNNGCIGKCPPTNSPDDYVVHLEHKEFILSIAVMGVIGEEIENKTDDSMILRPVNLIKHSCIGRCPITNTNTWSPIYFRHTYCD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MQX6</accession>
    <name>A0A8J2MQX6_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to Dnajc28: DnaJ homolog subfamily C member 28 (Mus musculus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS5459</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5090014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MQX6"/>
    <dbReference type="OrthoDB" id="1922282at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052573">
        <property type="entry name" value="DnaJ_C_subfamily_28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018961">
        <property type="entry name" value="DnaJ_homolog_subfam-C_membr-28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39158:SF1">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39158">
        <property type="entry name" value="OS08G0560600 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09350">
        <property type="entry name" value="DJC28_CD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="2">
        <location>
            <begin position="38"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="351"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5090014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="390" mass="45147" checksum="F5253D03499F9AD8" modified="2022-05-25" version="1">MLVYSPNCSSSINKLSFCLQRLKVNIKQCRYKHRTLKKSYETLGLKEDCEDEDLRLAFVHLAKQYHPDSGSSRADSMKFSEVKSFLLINKLLINQEEIPFNLLNLLQIESAYRLIQRERSSCKEDNDSLPEVEEFDIKHTAPQHRHFLAYDTGIGTPSERQRRHTRERAQKAVDNVMEHRLQKIQAAERNTLVGMDKRRAGDIKTRFGIDRLVEDLIQESMNKGEFKDLPGMGKPLKDRASAQNPYVDFVTHKLNEILIDNGFTPEWIQLSKEIREETKDLENYLTAVRNELGPAPLSFDEDKLWQNALKDSEETVKNINKKINTYNLLVPILQKQMLLINLDSIAKKVIEKPPSPSQNKKSRNNVTVDDNSMSTGMLDLLSWVFDRKKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MSF3</accession>
    <name>A0A8J2MSF3_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Short-chain specific acyl-CoA dehydrogenase, mitochondrial</fullName>
            <ecNumber evidence="4">1.3.8.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Butyryl-CoA dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">HICCMSTLAB_LOCUS11723</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Short-chain specific acyl-CoA dehydrogenase is one of the acyl-CoA dehydrogenases that catalyze the first step of mitochondrial fatty acid beta-oxidation, an aerobic process breaking down fatty acids into acetyl-CoA and allowing the production of energy from fats. The first step of fatty acid beta-oxidation consists in the removal of one hydrogen from C-2 and C-3 of the straight-chain fatty acyl-CoA thioester, resulting in the formation of trans-2-enoyl-CoA. Among the different mitochondrial acyl-CoA dehydrogenases, short-chain specific acyl-CoA dehydrogenase acts specifically on acyl-CoAs with saturated 4 to 6 carbons long primary chains.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>butanoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E)-butenoyl-CoA + reduced [electron-transfer flavoprotein]</text>
            <dbReference type="Rhea" id="RHEA:24004"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57332"/>
            <dbReference type="ChEBI" id="CHEBI:57371"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="EC" id="1.3.8.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:24005"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>hexanoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E)-hexenoyl-CoA + reduced [electron-transfer flavoprotein]</text>
            <dbReference type="Rhea" id="RHEA:43464"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="ChEBI" id="CHEBI:62077"/>
            <dbReference type="ChEBI" id="CHEBI:62620"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:43465"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>pentanoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E)-pentenoyl-CoA + reduced [electron-transfer flavoprotein]</text>
            <dbReference type="Rhea" id="RHEA:43456"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57389"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="ChEBI" id="CHEBI:86160"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:43457"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 14">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; mitochondrial fatty acid beta-oxidation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.8.1" evidence="4"/>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5103865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MSF3"/>
    <dbReference type="OrthoDB" id="10254877at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016937">
        <property type="term" value="F:short-chain fatty acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046359">
        <property type="term" value="P:butyrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033539">
        <property type="term" value="P:fatty acid beta-oxidation using acyl-CoA dehydrogenase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01158">
        <property type="entry name" value="SCAD_SBCAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.540.10:FF:000002">
        <property type="entry name" value="Acyl-CoA dehydrogenase FadE19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.10:FF:000004">
        <property type="entry name" value="Acyl-CoA dehydrogenase FadE25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.110.10:FF:000001">
        <property type="entry name" value="Acyl-CoA dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="entry name" value="Acyl-CoA dehydrogenase/oxidase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006089">
        <property type="entry name" value="Acyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43884">
        <property type="entry name" value="ACYL-COA DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43884:SF12">
        <property type="entry name" value="ISOVALERYL-COA DEHYDROGENASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016578">
        <property type="entry name" value="HsaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00072">
        <property type="entry name" value="ACYL_COA_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00073">
        <property type="entry name" value="ACYL_COA_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 14" id="KW-0274">FAD</keyword>
    <keyword evidence="5 14" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase N-terminal" evidence="17">
        <location>
            <begin position="33"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA oxidase/dehydrogenase middle" evidence="16">
        <location>
            <begin position="148"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase C-terminal" evidence="15">
        <location>
            <begin position="255"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00044204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00045387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00050758"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="CAG5103865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="411" mass="44765" checksum="8A1DF218D154E69E" modified="2022-05-25" version="1">MMMMYIPRLFLGFRTANKLHDRRWIASISSLPETHRMLQKTVRDFAEAELKPIAGQLDKEHKYPADQIKKMGELGLMSIATPESLGGTGLDYMAYVIAMEEISRGCASAGVIMSVNNSLYLGPIEKFGTQEQKEKYIVPFTDGSKVGCFALSEPGNGSDAGAASTMAKKEPDGYRISGTKCWITNANEAEGIVLFATTDKSKKHKGISAILVDRPSKGLEIGKKEDKLGIRASSTCSLMFEDCLVPEKNILGEPGMGFKIAMMTLDAGRIGIASQALGIAQASLECAIDYASKRMAFGKSIMKLQAIQQKIADMALRLESARLLTWRSAYLKDTGKPFTKEAAMAKLAASEAATYCSHQCIQILGGMGYVSDMPAERHYRDARITEIYEGTSEIQRLVIAGNIAKEYGVSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MTY6</accession>
    <name>A0A8J2MTY6_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS13947</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5109311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MTY6"/>
    <dbReference type="OrthoDB" id="7555365at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5109311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="208" mass="24155" checksum="1A78CFB35C511859" modified="2022-05-25" version="1">MVDVLRFLNDSGLELSPDKSRMEYCGFLIHPLSQKSLKNLNIIQNKALRIAMGYRQSTSTNIMFAEAKEPPIHLRMQYLCYNFLTKLLAKTKHPLIPILDHIIARRENPTLLFRGSKPLFLFAYEDTIPIQHYIACSDKPWCYNFSYESLWFIPDVDLDTGISIQKATNPRLKFENLFRHELRKASCWFTDGSKIDNNEFAGFANLDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MUC5</accession>
    <name>A0A8J2MUC5_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Endoplasmic reticulum transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">HICCMSTLAB_LOCUS13357</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="12">May play a role in anterograde transport of membrane proteins from the endoplasmic reticulum to the Golgi.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Endoplasmic reticulum membrane</location>
            <topology evidence="1 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the BCAP29/BCAP31 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5108678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MUC5"/>
    <dbReference type="OrthoDB" id="435607at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070973">
        <property type="term" value="P:protein localization to endoplasmic reticulum exit site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000011">
        <property type="entry name" value="B-cell receptor-associated protein 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008417">
        <property type="entry name" value="BAP29/BAP31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040463">
        <property type="entry name" value="BAP29/BAP31_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041672">
        <property type="entry name" value="Bap31/Bap29_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12701">
        <property type="entry name" value="BCR-ASSOCIATED PROTEIN, BAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12701:SF20">
        <property type="entry name" value="ENDOPLASMIC RETICULUM TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05529">
        <property type="entry name" value="Bap31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18035">
        <property type="entry name" value="Bap31_Bap29_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 12" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 12" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 12" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-0675">Receptor</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="48"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="101"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="BAP29/BAP31 transmembrane" evidence="14">
        <location>
            <begin position="1"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="Bap31/Bap29 cytoplasmic coiled-coil" evidence="15">
        <location>
            <begin position="181"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="179"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="223"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="183"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU367026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF05529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF18035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CAG5108678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="243" mass="27761" checksum="1BC4F09EC5038852" modified="2022-05-25" version="1">MSLQWTLIASFLYVEIFIVLLLVLPVASPKRWQSLFRSRFLQSLSNQASFYFFMLLAILVLFLLDAIREMNKYSNKEHTDHGHLDAEMQGSMRLFRAQRNFYISGFALFLSLVIRRLVILISTQATLLAQSEAALRQAQSATTTAKSLLSQKGETAQNDSNEAHDKVVTELKSQVSELSQKNTELENELKKEKKDKEALKSQAESLAKEYDRLTGEHARLVKAEGSDKKKTRVSISHHQIERK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MZ32</accession>
    <name>A0A8J2MZ32_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Similar to NID2: Nidogen-2 (Homo sapiens)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HICCMSTLAB_LOCUS12284</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5106486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MZ32"/>
    <dbReference type="OrthoDB" id="406800at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005604">
        <property type="term" value="C:basement membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004867">
        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007160">
        <property type="term" value="P:cell-matrix adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00191">
        <property type="entry name" value="TY"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="CDD" id="cd00199">
        <property type="entry name" value="WAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.22.10">
        <property type="entry name" value="Antistasin, domain 1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.75.10">
        <property type="entry name" value="Elafin-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.800.10">
        <property type="entry name" value="Thyroglobulin type-1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004094">
        <property type="entry name" value="Antistasin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006150">
        <property type="entry name" value="Cys_repeat_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051950">
        <property type="entry name" value="Dev_reg/Prot_inhib"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036645">
        <property type="entry name" value="Elafin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011061">
        <property type="entry name" value="Hirudin/antistatin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036880">
        <property type="entry name" value="Kunitz_BPTI_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028150">
        <property type="entry name" value="Lustrin_cystein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000716">
        <property type="entry name" value="Thyroglobulin_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036857">
        <property type="entry name" value="Thyroglobulin_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008197">
        <property type="entry name" value="WAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12352:SF31">
        <property type="entry name" value="PAPILIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12352">
        <property type="entry name" value="SECRETED MODULAR CALCIUM-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02822">
        <property type="entry name" value="Antistasin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14625">
        <property type="entry name" value="Lustrin_cystein"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00086">
        <property type="entry name" value="Thyroglobulin_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00095">
        <property type="entry name" value="WAP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00211">
        <property type="entry name" value="TY"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00217">
        <property type="entry name" value="WAP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00289">
        <property type="entry name" value="WR1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57362">
        <property type="entry name" value="BPTI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57262">
        <property type="entry name" value="Leech antihemostatic proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57610">
        <property type="entry name" value="Thyroglobulin type-1 domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51252">
        <property type="entry name" value="ANTISTASIN"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00484">
        <property type="entry name" value="THYROGLOBULIN_1_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51162">
        <property type="entry name" value="THYROGLOBULIN_1_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51390">
        <property type="entry name" value="WAP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="1198"/>
            <end position="1218"/>
        </location>
    </feature>
    <feature type="domain" description="WAP" evidence="9">
        <location>
            <begin position="58"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="Thyroglobulin type-1" evidence="7">
        <location>
            <begin position="108"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="Antistasin-like" evidence="8">
        <location>
            <begin position="185"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="WAP" evidence="9">
        <location>
            <begin position="304"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="domain" description="Thyroglobulin type-1" evidence="7">
        <location>
            <begin position="352"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="domain" description="Antistasin-like" evidence="8">
        <location>
            <begin position="435"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="domain" description="Antistasin-like" evidence="8">
        <location>
            <begin position="600"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="domain" description="WAP" evidence="9">
        <location>
            <begin position="660"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="domain" description="Thyroglobulin type-1" evidence="7">
        <location>
            <begin position="708"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="domain" description="Antistasin-like" evidence="8">
        <location>
            <begin position="776"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="domain" description="Thyroglobulin type-1" evidence="7">
        <location>
            <begin position="949"/>
            <end position="1016"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="149"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="390"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="399"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="987"/>
            <end position="994"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="996"/>
            <end position="1016"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAG5106486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="1278" mass="138815" checksum="98942CE8BCB61BE1" modified="2022-05-25" version="1">MLNNPDLVRASGVKPNNKTVHFKICCNNVNSSPNGNGVIIKCPNGERKGLDRGREKPLLRSPGRCPALNEQSTCPSRAAPCSSNFECSSSTEKCCETVCGLKCVASELTGCEQLALAATRRSRALGTRGPSQFIPQCNNFTGEFERIQCEATEKNCWCVDEFGSELPGTRSAGREFVDCNNPRLCQAHSCRMLCPLGFQIDEETGCPKCECRDPCHNVTCPGVGQTCELIESSCARPPCPPIPSCRKAKSLATICPAGEPLQITDSPRPFLCGESIGKPSCPPMYRCVVEPNQEYGVCCPSTLNLERPGKCPPEEPAVCGPPCQHDLDCSGPQKCCESDSCGGGVCLLPVGLSACRKNRMLAEMLSVSEKQGRGYIPQCNEAGGYEPKQCSRNGLVCWCVRVDGKKISGTMGPAAAVNCNQVTDKSKGRALPTSCPLYHCAQVCQYGFKVDEAGCSTCECDNPCEGFPCPADQECVLNRENGCPDFLCPTTPECRAKKSYKSPCVTGAPLSDEGGNAVTCTGTNSTCPSSHICTAVPEAGQSVCCPMLHILTPPTNGTWKSLQCHDSRCDCVNEQGVPLRTNITTTDVDCDEVRALSKTCEPPECDIQCTYGREVDDAGCEQCRCRDPCQGVSCGPREICSMVDVNCGEGQSCPQVPACLAVKQGQCPYLVPSSSSCEVHCSNDQECSDDRKCCSTGCGTACVEPVVATGCQHARTLAEHAARESGEPARRIYIPQCDEKGSFESVQCHLGTCWCVDEEGREAAGTRVPDGAPVTCPTIECHLDCPDGLDLDPSGCPRCSCRDPCKAVNCRGENEACRMVEVACSAPPCPPVPVCLPKKDNPCPNGAPLLTQEGLPAICGPHGQHCPTTHKCELSPLDEYAVCCPKPRDVCFEPPRLIECPPTRQKGMNDTERWYFDPELNECRIKTGCSVGHNDFSSKLVCDDVCPVLTPCELQRERNLKNSQRLKKSVFLPRCNADTGAWESVQCLEHVGVCWCVDRKGVPVKGSLVRGEEPKCNFRQARKGGKSSLIEIDPEIAAYMENSLVKLDVEEERMEKPVAKLLVTRCEAMKERVEAVEVTLRFPGHFVNEDTNRFTRATADLLRDLNASIKDGIAVELDLDAAIIGFEIVGDNKVDVAFHLEELTRSRSLALLGSIADATTSRFIHRPLSFEAEDKIMALEQRELFTDAETPIYQTTTVVLAATSAIIICSFIILFVIYRRKMKVRYCTPKGEETDERYLAYDKQPVYVISGADKDDKDIEVARELCESHSTGKEIAQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MZA9</accession>
    <name>A0A8J2MZA9_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Similar to Madm: Nuclear receptor-binding protein homolog (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HICCMSTLAB_LOCUS13840</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5109204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MZA9"/>
    <dbReference type="OrthoDB" id="1034557at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000098">
        <property type="entry name" value="Nuclear receptor-binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050588">
        <property type="entry name" value="WNK_Ser-Thr_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13902">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE WNK WITH NO LYSINE -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="5">
        <location>
            <begin position="1"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="323"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="11"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="22"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="324"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAG5109204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="529" mass="58916" checksum="2B437A6660567DE3" modified="2022-05-25" version="1">MPGSRSSTAADPDHKSPRESGEDSEDESEILEESPCGRWLKRREEVGQRDVPGIDCAYLAMDTEEGVEVVWNEVQFSERKDFKAQEEKIQLVFENLIQLEHPSIVKFHRYWTDTHNDKPRVIFITEYMSSGYLHSCSPPIVHGNLTCDTIFIQHNGLVKIGSVAPDAIHHDGRTCRTNVKNMHFVAPEYGNLLTPAIDIYAFGVCALEMAALEIHGNGDSGSPVTDENIQKTIESLDDPLQKDFIRKCLQSEPLSRPSARELLFHPILFEVPSLKLLAAHALVSSATNISETITDQVLQRLYGPDTVVAEIRYQNQLSPSVAISSKSSSSSSSSSSSSQPPLQQIRLSDISVTEKLEKFVEDVKYGIYPLTTCMARLPPPSAVRPRAISPEITESVKSVTPEPLTPEARRIVHMMCNLTCPVTETDTPLILAQDLVDNAFINESDRDALARLMEETIRSFYNKQKMRPAMVSLTNLPTSLLLPESELPRIQDLETLNHNASLTSPPSSVSLNTTVLSNDLYFFAAKERI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MZG3</accession>
    <name>A0A8J2MZG3_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Similar to dlg1: Disks large 1 tumor suppressor protein (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HICCMSTLAB_LOCUS12782</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5107515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MZG3"/>
    <dbReference type="OrthoDB" id="78824at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016323">
        <property type="term" value="C:basolateral plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031594">
        <property type="term" value="C:neuromuscular junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098839">
        <property type="term" value="C:postsynaptic density membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098609">
        <property type="term" value="P:cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007268">
        <property type="term" value="P:chemical synaptic transmission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045197">
        <property type="term" value="P:establishment or maintenance of epithelial cell apical/basal polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043113">
        <property type="term" value="P:receptor clustering"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097120">
        <property type="term" value="P:receptor localization to synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099072">
        <property type="term" value="P:regulation of postsynaptic membrane neurotransmitter receptor levels"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06723">
        <property type="entry name" value="PDZ1_Dlg1-2-4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06724">
        <property type="entry name" value="PDZ2_Dlg1-2-4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.42.10:FF:000002">
        <property type="entry name" value="Disks large homolog 4 isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.42.10:FF:000004">
        <property type="entry name" value="Disks large homolog 4 isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050614">
        <property type="entry name" value="Synaptic_Scaffolding_LAP-MAGUK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23119">
        <property type="entry name" value="DISCS LARGE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23119:SF51">
        <property type="entry name" value="DISKS LARGE 1 TUMOR SUPPRESSOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDZ" evidence="4">
        <location>
            <begin position="10"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="4">
        <location>
            <begin position="105"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="198"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="222"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="237"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="253"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAG5107515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="294" mass="31011" checksum="FD1197DB052253BB" modified="2022-05-25" version="1">MIATTWTYHDLAAHSMRGGAGLGFSIAGGTDNPHFGNDTAIYITKLIPGGAASADGRLRVNDTILQVNEVSVVDVPHASAVDALKKAGNTVKLYVRRRRHLHLTEIELIKGSKGLGFSIAGGIGNQHIPGDNGIYVTKIMDGGAAQVDGRLIVGDKLVAVRNSLGDKNLENVTHEEAVATLKATQDRVVLLVAKPEGVLPPPPPASDHSLSPQPPWHAFHTPSPPVTATPPNPGFAQSIQTQKKTQSLKSKQNGSVTALENNSLAYSQESRHASSLALHGAVTPRAVSQEDISR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2N0X3</accession>
    <name>A0A8J2N0X3_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Similar to ZBTB20: Zinc finger and BTB domain-containing protein 20 (Homo sapiens)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HICCMSTLAB_LOCUS14059</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001579">
        <property type="protein sequence ID" value="CAG5109897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2N0X3"/>
    <dbReference type="OrthoDB" id="10004641at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235">
        <property type="entry name" value="KRUEPPEL-LIKE TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235:SF120">
        <property type="entry name" value="KRUPPEL-LIKE FACTOR 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="9"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="37"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="54"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="65"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAG5109897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="79" mass="9325" checksum="EEF502F09984A309" modified="2022-05-25" version="1">MECGKAPRYQCRICHGKFTHKHNLAAHMKLHIEEPKYACLNCDKKFYRRDKLAKHSATHQVAGQEVKDEKKIRGKNYKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-10-16" modified="2023-09-13" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>S6CVQ6</accession>
    <name>S6CVQ6_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Cc_bv10.2_28.17</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">bv10-2</name>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS6166</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Philos. Trans. R. Soc. Lond., B, Biol. Sci." volume="368" first="20130047" last="20130047">
            <title>Functional endogenous viral elements in the genome of the parasitoid wasp Cotesia congregata: insights into the evolutionary dynamics of bracoviruses.</title>
            <authorList>
                <person name="Bezier A."/>
                <person name="Louis F."/>
                <person name="Jancek S."/>
                <person name="Periquet G."/>
                <person name="Theze J."/>
                <person name="Gyapay G."/>
                <person name="Musset K."/>
                <person name="Lesobre J."/>
                <person name="Lenoble P."/>
                <person name="Dupuy C."/>
                <person name="Gundersen-Rindal D."/>
                <person name="Herniou E.A.Drezen.J.M."/>
            </authorList>
            <dbReference type="PubMed" id="23938757"/>
            <dbReference type="DOI" id="10.1098/rstb.2013.0047"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5092494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="HF586473">
        <property type="protein sequence ID" value="CCQ71219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S6CVQ6"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5092494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCQ71219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="96" mass="10715" checksum="8F2789086DF60257" modified="2013-10-16" version="1">MMIAMKINQFFSQLKCVGLKLTRESDVSSDLETGYPGDLEASSDFEHLQARHRWSRILVASEIEGSSYYGGTALMLLVSQRKSDLQICGLPCCHSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2E232</accession>
    <name>A0A8J2E232_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS1153</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001116">
        <property type="protein sequence ID" value="CAG5074942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2E232"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5074942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="161" mass="18711" checksum="EFC7D8A01A66D8EE" modified="2022-05-25" version="1">MAEFFKICAMRTAICEISEENKDGKNVLFEFKHVFTKITHLSGWINSPTFETPKILGVKFLISASINNVASKVSVRVIKDDIREAVSIIKISFDGLFNSTRRVVDWKNMLLFESLIIPFDFDVCHRYIDYPKFYAHGKSPHEYTIPIICEIIWNGFVEDFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2E3H9</accession>
    <name>A0A8J2E3H9_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Receptor ligand binding region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HICCMSTLAB_LOCUS1985</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001116">
        <property type="protein sequence ID" value="CAG5076004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2E3H9"/>
    <dbReference type="OrthoDB" id="6586065at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001828">
        <property type="entry name" value="ANF_lig-bd_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01094">
        <property type="entry name" value="ANF_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="Periplasmic binding protein-like I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="417"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="domain" description="Receptor ligand binding region" evidence="7">
        <location>
            <begin position="2"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="327"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="478"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="327"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="353"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="374"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="401"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="482"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="493"/>
            <end position="505"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG5076004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="505" mass="56518" checksum="5429CF3EEF0AF1B6" modified="2022-05-25" version="1">MSEAAKMFVDAHNAKNNNLKIDLSVLDTCGTVTGATTAAMKALSSSCLHPPYFLGLIGPESPQNIDAVQKITSILHVPHIVHTNSMSSPYLHNLHEETDSYIVQGILEILEVLKWKSFTLTTPKYNSNSNKDDDIQVIAKKVTNGAISRGLCVMIHDEDDSDDFSSRIVYIGKPPKSFFKNLASTVVIASEGNLRSYIDKIDYSHSIVLLGDTRTDLAGIESKVENSKLWSNKEVERFDTEEMREIRWLKDALEVYTKSYDLLCKKKKCSSEVNHAEWNTLIGNVISTKNAQLQIATRTIDIYLRVKNGVLDKLGEIKVKKNDAIVDWDDENSNNNGNDDDDVMPDLFRGLLSNGNDKTNDCATSSKNFKTRNNPKINNNNNNNNNNNNNHNHNRKKYNNDDDDDDDDDDDDDISRVAVVSGIGVSMFTIGILAVYVVFNNIRGPRSPKHKGGRRYSSNGSVIRRVNSERELQIVTQTPIHHPSRPNQRRNSNHSLGSVISDKSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2E642</accession>
    <name>A0A8J2E642_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS1140</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001116">
        <property type="protein sequence ID" value="CAG5074929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2E642"/>
    <dbReference type="OrthoDB" id="565904at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000302">
        <property type="term" value="P:response to reactive oxygen species"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012674">
        <property type="entry name" value="Calycin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10612">
        <property type="entry name" value="APOLIPOPROTEIN D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10612:SF34">
        <property type="entry name" value="APOLIPOPROTEIN D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50814">
        <property type="entry name" value="Lipocalins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035221676" evidence="1">
        <location>
            <begin position="16"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5074929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="171" mass="19717" checksum="74BC90979F4D5938" modified="2022-05-25" version="1">MRVLIVLISCAIAAAVPSCPNIRVIIDTNLASGTWYEFQRSDNNLISNGTCTTVIFHQPDECICRMVYCDDQMAEKTLLAEIVPKRSDVFYYRFPLIDIFDKEYYIIDTDYINYTVLMSCDQNYGIPKFVVVTRNPYPDDETIKKILQSFPKRRLNTPNLVAINNEDCGKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2E786</accession>
    <name>A0A8J2E786_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Similar to evl-20: ADP-ribosylation factor-like protein 2 (Caenorhabditis elegans)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HICCMSTLAB_LOCUS1820</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Arf family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001116">
        <property type="protein sequence ID" value="CAG5075706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2E786"/>
    <dbReference type="OrthoDB" id="25466at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044612">
        <property type="entry name" value="ARL2/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45697">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-0519">Myristate</keyword>
    <keyword evidence="3 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="36"/>
            <end position="39"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAG5075706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="108" mass="11904" checksum="04381B6C19AE2B9B" modified="2022-05-25" version="1">MVDASDANQLSQAVLSLKEILGDSRMDNVPILVIANKQDVPDALKADQIKRALDLHSISPHKHKVEVITCQTMPIPDSAKKPGTSEYSYYHPSMMNVRKKIFSLASAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2E995</accession>
    <name>A0A8J2E995_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Similar to DNAJC3: DnaJ homolog subfamily C member 3 (Homo sapiens)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HICCMSTLAB_LOCUS715</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001114">
        <property type="protein sequence ID" value="CAG5073943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2E995"/>
    <dbReference type="OrthoDB" id="1726119at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051787">
        <property type="term" value="F:misfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034975">
        <property type="term" value="P:protein folding in endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.110:FF:000015">
        <property type="entry name" value="dnaJ homolog subfamily C member 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051727">
        <property type="entry name" value="DnaJ_C3_Co-chaperones"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44140">
        <property type="entry name" value="LD25575P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44140:SF2">
        <property type="entry name" value="LD25575P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00515">
        <property type="entry name" value="TPR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13432">
        <property type="entry name" value="TPR_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13174">
        <property type="entry name" value="TPR_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0802">TPR repeat</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035272190" evidence="6">
        <location>
            <begin position="20"/>
            <end position="928"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="4">
        <location>
            <begin position="22"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="4">
        <location>
            <begin position="56"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="4">
        <location>
            <begin position="90"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="4">
        <location>
            <begin position="370"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="4">
        <location>
            <begin position="404"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="4">
        <location>
            <begin position="438"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="4">
        <location>
            <begin position="771"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="7">
        <location>
            <begin position="825"/>
            <end position="893"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="882"/>
            <end position="911"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="882"/>
            <end position="902"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG5073943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="928" mass="106596" checksum="2FF2F13299A93B69" modified="2022-05-25" version="1">MFPGGFLFILLNLYSDVGGNNVNEHLEMGRSFLMRGQLQDALTHCHAAVDGDPNNYRTYYQRGIAYLALEKPKVALQDFDKVLELKPDFIAARFQRASVLFKLGQFDKARQDYQVVLEVEPTNDEALKYYYLIDEVRDIIDHAKSQVTSGRYYKAVELITSAIESCPWNAELRELRAECHVANKDYMNAVADFHSAAKLLSDNTEGLLKLSKFLYRLGHVSESLNEIRSCLKRDPEHKECFKFYKKIKDVAKNLEEASLAEESRDHPKCVKTALKALKLESNVEDVKLKIYQLLCSCMSHTDPNSAVEYCREALKLHKDQISLYDRAEASLTALASREQTNSRTFMYWSAKSLLARQPSAAPDSLGGSDVDKHLEMGRSFLMRGQLQDALTHCHAAVDGDPNNYRTYYQRGIAYLALEKPKFALQDFDKVLDLKPDFIAARFQRASVLFKQGQFEKARQDYQVVLEVEPTNDEALKYYYLIDEVRDTIDHAKSQVTSGRYYKAVELITSAIESCPWNAELRELRAECHVANKDYMNAVTDFHSAAKLLSDNTEGLLKLSKFLYRLGHLEVEPTNDEALKYYYLIDEVRDTIDHAKSQVTSGRCYEAVKLITSTIESCPWNAELRELRAECHVANKDYMNAVTDFHSAAKLLSDNTEGLLKLSKFLYRLGHVSESLNEIRSCLKRDPEHKECFKFYKKIKDVAKNLEEASLAEESRDHPKCVKTALKALKLESDVENVKLKIYQLLCKCMPHTDPNSAVEYCQEALKLHKDQNSLCDRAEAYLAAEMYDDAIIDLKQALEIDPNFQRAKELLQTAQQRQKMSESRDYYKILGVNRNAPKKEIIKAYRKAAQTWHPDNFQDGEEKKRAEKKFIDIAAAKEVLTDPEKRAKFDRGEDPLDPESGRHPSNFNPFQEFHQFHGSPFQFKFHFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2EIC0</accession>
    <name>A0A8J2EIC0_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pre-mRNA-splicing factor 18</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">PRP18 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HICCMSTLAB_LOCUS400</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PRP18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001114">
        <property type="protein sequence ID" value="CAG5073457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2EIC0"/>
    <dbReference type="OrthoDB" id="10261918at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071021">
        <property type="term" value="C:U2-type post-spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000350">
        <property type="term" value="P:generation of catalytic spliceosome for second transesterification step"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.280.110:FF:000001">
        <property type="entry name" value="pre-mRNA-splicing factor 18 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.940.10">
        <property type="entry name" value="Functional domain of the splicing factor Prp18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.110">
        <property type="entry name" value="Pre-mRNA processing factor 4 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004098">
        <property type="entry name" value="Prp18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014906">
        <property type="entry name" value="PRP4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036285">
        <property type="entry name" value="PRP4-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039979">
        <property type="entry name" value="PRPF18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13007">
        <property type="entry name" value="PRE-MRNA SPLICING FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13007:SF19">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02840">
        <property type="entry name" value="Prp18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08799">
        <property type="entry name" value="PRP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00500">
        <property type="entry name" value="SFM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47938">
        <property type="entry name" value="Functional domain of the splicing factor Prp18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158230">
        <property type="entry name" value="PRP4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Pre-mRNA processing factor 4 (PRP4)-like" evidence="10">
        <location>
            <begin position="72"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="40"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="40"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAG5073457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="274" mass="31933" checksum="F6BF1501BDD5A09F" modified="2022-05-25" version="1">MNFLQAEILKKRKELEESNLLQNKRKYFKVAELTLNKVETSESNNNNTDTINTVENKNSEGSVENTVEHQKLSRPEVIKRLRERSEPILLFGESELESFQRLRKCEILQPEVNKGFRNDFQEAMDQVDQAYLNELLSSSKPTNECNKGDVNIPDEQVTYEDIEKMSVKLNRGDRDFDMSVITQFLQFLVLMWGMQLNSRSAAEKMSTKGKMASATYAQTREYLKPLLRKLKNKSLPEDITDSLTEIVKHLLERNYILVSFRCKLKLIHSIYINI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2ELB6</accession>
    <name>A0A8J2ELB6_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS2306</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001117">
        <property type="protein sequence ID" value="CAG5076871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2ELB6"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5076871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="60" mass="6852" checksum="872DABB9E13A6B94" modified="2022-05-25" version="1">MKFGHADPVIIHVHATFLKNFMYEYCNLTGTFWKPTVTSTKAEDAKNSQDMSKKQDGDLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2EP92</accession>
    <name>A0A8J2EP92_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS2329</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001117">
        <property type="protein sequence ID" value="CAG5076943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2EP92"/>
    <dbReference type="OrthoDB" id="6159439at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="227"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="76"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="119"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="227"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5076943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="246" mass="25533" checksum="A4300B0915E6C630" modified="2022-05-25" version="1">MPLAPTPIVPVPSKPKIGFSIDSIVGGGGGGGRENRLEIERDGSPMEVVEGSSSPRLRRVTRSPGAHSEGSDRPLSRSSSVESYPSRLNGHPHPAARHHHHHHLQGLTHLDYSRTQNRSHSGGSTPNNSPSPPHRISHGDSPVGAHPQPPPGVVRPSPNYLGPPPGAATAAAVAAEQIKSLYGLQAGHGGPQGQSEYHSQQFALAANLAAAQNFQASNLALALQAHHGGAPHGSPHGPHIFSAVNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2GZD5</accession>
    <name>A0A8J2GZD5_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS373</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001114">
        <property type="protein sequence ID" value="CAG5073430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2GZD5"/>
    <dbReference type="OrthoDB" id="7675130at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5073430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="107" mass="12540" checksum="9365C24BAF346E5B" modified="2022-05-25" version="1">MTICVMNILVNQTRCELNIKNLSKVLLIFQVRMPPKCRVPIDDAINVLIKYISYFASDQLPEWSSDVWDKMSNEPEFKDKWNVPCIRTNIKENSYSTRYSNESKGTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2GZZ7</accession>
    <name>A0A8J2GZZ7_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PIH1 domain-containing protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HICCMSTLAB_LOCUS43</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="3">Involved in the assembly of C/D box small nucleolar ribonucleoprotein (snoRNP) particles. Recruits the SWI/SNF complex to the core promoter of rRNA genes and enhances pre-rRNA transcription. Mediates interaction of TELO2 with the R2TP complex which is necessary for the stability of MTOR and SMG1. Positively regulates the assembly and activity of the mTORC1 complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PIH1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030000345">
        <property type="protein sequence ID" value="CAG5071441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2GZZ7"/>
    <dbReference type="OrthoDB" id="5135119at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097255">
        <property type="term" value="C:R2TP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000492">
        <property type="term" value="P:box C/D snoRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050734">
        <property type="entry name" value="PIH1/Kintoun_subfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012981">
        <property type="entry name" value="PIH1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041442">
        <property type="entry name" value="PIH1D1/2/3_CS-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22997">
        <property type="entry name" value="PIH1 DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22997:SF0">
        <property type="entry name" value="PIH1 DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08190">
        <property type="entry name" value="PIH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18201">
        <property type="entry name" value="PIH1_CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PIH1 N-terminal" evidence="4">
        <location>
            <begin position="20"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="PIH1D1/2/3 CS-like" evidence="5">
        <location>
            <begin position="236"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00040540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00046233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF18201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAG5071441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="295" mass="33960" checksum="7FAF6A1A50B1287F" modified="2022-05-25" version="1">MSNVLEIDESIITNNLLLPENKQQDEDLNSLLKSFESPASVTFKPTPGVCIKAKTDKNEKVFINLCHTKEVPAPEDLTDIEFENMLKEEPPSWSIPMSVGYERFESAKDGTKCPTYDIAINSEYFQKCESKYHFMQFTIWTILSAIEAKYDKVLSADNFVILKNRKVNGTLHEHRVEKRKPKKPKELLQERKPLIQEIKSGVKDAAVNQDSYVLLREPKEGQMLKSIGYFRLPNKVVDDKDIKVQVNQERVVVNVDKFHYLVDLFVPFSIKTDKVSAHYDPNLQVLRLEMPVLLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H174</accession>
    <name>A0A8J2H174_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">UDP-glucuronosyltransferase</fullName>
            <ecNumber evidence="5">2.4.1.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HICCMSTLAB_LOCUS316</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>glucuronate acceptor + UDP-alpha-D-glucuronate = acceptor beta-D-glucuronoside + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21032"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58052"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:132367"/>
            <dbReference type="ChEBI" id="CHEBI:132368"/>
            <dbReference type="EC" id="2.4.1.17"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Membrane</location>
            <topology evidence="5">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the UDP-glycosyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.17" evidence="5"/>
    <dbReference type="EMBL" id="CAJNRD030001114">
        <property type="protein sequence ID" value="CAG5073372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H174"/>
    <dbReference type="OrthoDB" id="5835829at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015020">
        <property type="term" value="F:glucuronosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd03784">
        <property type="entry name" value="GT1_Gtf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000050">
        <property type="entry name" value="UDP-glucuronosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050271">
        <property type="entry name" value="UDP-glycosyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002213">
        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035595">
        <property type="entry name" value="UDP_glycos_trans_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48043">
        <property type="entry name" value="EG:EG0003.4 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48043:SF145">
        <property type="entry name" value="FI06409P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00201">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00375">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="3 4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035341313" description="UDP-glucuronosyltransferase" evidence="5">
        <location>
            <begin position="25"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="474"/>
            <end position="496"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAG5073372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="527" mass="59379" checksum="3C0FAAA91281D6AE" modified="2022-05-25" version="1">MCSLKVILTVFMVTIGGQYQSAEALKILGLFPLAGRSHFIPPARLMKELAAKGHQVDVVSHFPLKNPVPNYRDISLKGLAPISTNNMSYDQTQTVGGFSMHNFVSLTGTQVCDLLSTPVFEKLLKTPKGTYDLIVLELFTADCYMAFGKHLGAPIVAMVMSKMHDWLYGHFGIPFNTAYMPSLFSSFDQSMTYLERLQNTFVSAFIVPQVNYYKQEQLTHVEKYFGRKLTNMAELYKDVSIVLLNSHHSLYDIIPTPPGVIEVGGLHVHDDQQELTPEVKKWLDESKDGCVYFTFGSMVRIETFPAKTLAAFYETFKKIAPTRVLMKIADPSLLPAGLPKNVITSSWLPQVAVLKHKNTKVFITHGGLMGTQESLAHGVPMVGIPIFGDQFTNLQIYERRKIAVVLKQEDITAESFTKAVTTVLTDPVYRENIKRLSKLFLDRPMSAMDTAIYWVEYTARHGNILKSPATKLSWWEYYLIDVYGLVLLCIAVVLYITKFILKLLWRLVCSRKSSQAKSTAAKTKKNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H2Q4</accession>
    <name>A0A8J2H2Q4_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to ORF1: Nucleic-acid-binding protein from transposon X-element (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS1567</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001116">
        <property type="protein sequence ID" value="CAG5075413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H2Q4"/>
    <dbReference type="OrthoDB" id="6624230at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33273">
        <property type="entry name" value="DOMAIN-CONTAINING PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33273:SF2">
        <property type="entry name" value="ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14529">
        <property type="entry name" value="Exo_endo_phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="2">
        <location>
            <begin position="390"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="286"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="297"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5075413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="574" mass="65786" checksum="28F5E24B8D886772" modified="2022-05-25" version="1" fragment="single">MTYTHSQQNTQEFQQAGTSSQTIDPENLKTFRPLLIFVTGEKVSDSIKTLKNAGLPQDSFSVSISKVLHSIQVMKQIDYDKVKLALKSNQIQFYSFTPKGEKLKSILLKGVSEEYTTEQALEDLLSRNIPSVEIKKVTELKFVHDNQERRHLIVSSLKELFKIKNVLHMKTRWERLRRNKLLQCRRCQRIGHTAANCEMLFRCVKCGETHEPGKCLLNTATSRENFKCANYGKPGHPANYTGCKYIKFAHLSKKAELQSRNKSLAKKIDQVTGNYFPPRQFSNTAAQQKDAFPPLPSRNQANGIIQRSQPSPWQTSPPIGENAQPDWLAQIKNEICSLTNHYLLSNTYSIIRTDRPLQTRIIRYPSSNKNELLEFTIVQLLTETSPTTNIFIISCYTTNSNKRIFIHELNDLLQRLDLNNPNNSFILAGDLNARRIEWSDSDDNQRGKFLRNWEKDTLAKYRAKIYSTEEASFTPAKTFLDVCITDLIITNLTSNGKINTADYDSDHRALLFTIVLPSHTQQDHIPKPCRNIRAIKWKKFEKIANTNYTQDIPADRNLSIPEIDSNITVLTSTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H3N5</accession>
    <name>A0A8J2H3N5_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS1994</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001116">
        <property type="protein sequence ID" value="CAG5076013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H3N5"/>
    <dbReference type="OrthoDB" id="7661986at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032062">
        <property type="entry name" value="DUF4803"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47890">
        <property type="entry name" value="LD24308P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47890:SF1">
        <property type="entry name" value="LD24308P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16061">
        <property type="entry name" value="DUF4803"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035214186" evidence="1">
        <location>
            <begin position="21"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5076013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="442" mass="49931" checksum="82311617E2D96037" modified="2022-05-25" version="1">MSCYLFLCLILALGFKNIDGYNLTSGNHMEVIQPQLSDALTGNNTFSFTDLFSNIYISTSQLKGNDTCSLSCANINTVEKLNCLKEENSKDTQSLQVPEYCPAKPCHGRIHKCFIKNYEEFCELPPGGGRRYHWLLRNPTEDMRKNCPGRLVNMMTRSICLDCFCQCSEEGAQSTATRTVSFLQQSADVKNNMVISDVKLIKEDNVVQIKIEQAKLLPQGKLDEKTRAWVPVDTLIYQQNVSEGAFWASRNNSRVPLVKDVDYTFLNYEKRRLNLDDVLVDKDWIITGVRFRNSEDGGPTSSIQIEVSKTKFDYQTGLLSSVKEEQHVPVVANNITQSHNSHYHTNRSAKRVVKRKAPAGDFTTEVISSPNQYLEFRLAKMMNFNESVAPFLDARPVAEKNVVPYSGIGIVYRSSRTLSGTPGVISLRLFGIDHSKFDKKIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H3U3</accession>
    <name>A0A8J2H3U3_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Extracellular superoxide dismutase [Cu-Zn]</fullName>
            <ecNumber evidence="4">1.15.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Superoxide dismutase copper chaperone</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">HICCMSTLAB_LOCUS1662</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>2 superoxide + 2 H(+) = H2O2 + O2</text>
            <dbReference type="Rhea" id="RHEA:20696"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:18421"/>
            <dbReference type="EC" id="1.15.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the Cu-Zn superoxide dismutase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11">In the C-terminal section; belongs to the Cu-Zn superoxide dismutase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.15.1.1" evidence="4"/>
    <dbReference type="EMBL" id="CAJNRD030001116">
        <property type="protein sequence ID" value="CAG5075508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H3U3"/>
    <dbReference type="OrthoDB" id="666972at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004784">
        <property type="term" value="F:superoxide dismutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00305">
        <property type="entry name" value="Cu-Zn_Superoxide_Dismutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00371">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.200:FF:000004">
        <property type="entry name" value="Copper chaperone for superoxide dismutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.200">
        <property type="entry name" value="Superoxide dismutase, copper/zinc binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006121">
        <property type="entry name" value="HMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036163">
        <property type="entry name" value="HMA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036423">
        <property type="entry name" value="SOD-like_Cu/Zn_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024134">
        <property type="entry name" value="SOD_Cu/Zn_/chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001424">
        <property type="entry name" value="SOD_Cu_Zn_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10003">
        <property type="entry name" value="SUPEROXIDE DISMUTASE CU-ZN -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00403">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00080">
        <property type="entry name" value="Sod_Cu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00068">
        <property type="entry name" value="CUZNDISMTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49329">
        <property type="entry name" value="Cu,Zn superoxide dismutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55008">
        <property type="entry name" value="HMA, heavy metal-associated domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50846">
        <property type="entry name" value="HMA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="9" id="KW-0186">Copper</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="HMA" evidence="15">
        <location>
            <begin position="6"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00025798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00032899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00049204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00072705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CAG5075508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="274" mass="29621" checksum="98D932A6E2BD8DBB" modified="2022-05-25" version="1">MSDKMASKIEFAVNMTCEKCVNAIKNCLSNDKDISKLDVSLDRGTVLVETKLPYTVIQEKIESLGKRAVLKGFGDGSSAVSMIGGTSGFSRNLNTQGVVRFIETQKGCLVDGTIDGLSPGAHGLHIHECGDISNGCESVGSHLNPYNCSHGGPQDDISNKHMGDLGNIIADKAGRALFRFQNDDIKVSDIIGRSLVVTENEDDLGKGKNLNSKIDGNSGSKIACGIIARSCGIFENVKKICSCDGKTLWDERDESKKKYTQLLNFKNINLDEKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H667</accession>
    <name>A0A8J2H667_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similar to RF_0381: Putative ankyrin repeat protein RF_0381 (Rickettsia felis (Strain ATCC VR-1525 / URRWXCal2))</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS2650</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001117">
        <property type="protein sequence ID" value="CAG5078119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H667"/>
    <dbReference type="OrthoDB" id="10012027at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051616">
        <property type="entry name" value="Cul2-RING_E3_ligase_SR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46224">
        <property type="entry name" value="ANKYRIN REPEAT FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46224:SF64">
        <property type="entry name" value="IQ MOTIF AND ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="39"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="81"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="117"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="225"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5078119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="310" mass="34659" checksum="79FF11DF9CD9007B" modified="2022-05-25" version="1">MIYHVSHHLLLALKMNSLELVRHAVEETENINEFIDVTLPYTPLHLAILLRSSLEITEFLIDKGADVNSLCGESPYPNVMSKCTPLHLAISKNKRIEIDYAELLIRRGADVNIVFSGGQSALHLAVRSKNLQLVNLVLRNNANVNLNSEYGSPLMVFVENFILGLDNLDIMKLLLEFGADANCVSDKYPNESLLHVVVKSGSIEALKLLMSQGSADININIVTTNGMTALHYAVLSPDLNDGVIRVLLDSGIDWKITDNHGICANDYYPKLLINFFYSERNTEDFLANSYFEFEEKYKETNVEESEPAGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H6C0</accession>
    <name>A0A8J2H6C0_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Similar to FIG4: Polyphosphoinositide phosphatase (Homo sapiens)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HICCMSTLAB_LOCUS2752</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001117">
        <property type="protein sequence ID" value="CAG5078476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H6C0"/>
    <dbReference type="OrthoDB" id="405996at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043813">
        <property type="term" value="F:phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043573">
        <property type="entry name" value="Fig4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002013">
        <property type="entry name" value="SAC_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45738">
        <property type="entry name" value="POLYPHOSPHOINOSITIDE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45738:SF5">
        <property type="entry name" value="POLYPHOSPHOINOSITIDE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02383">
        <property type="entry name" value="Syja_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50275">
        <property type="entry name" value="SAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAC" evidence="5">
        <location>
            <begin position="207"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="783"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="795"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="809"/>
            <end position="824"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAG5078476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="983" mass="113305" checksum="4D21CF92BB59A995" modified="2022-05-25" version="1">MESSEPNIIFHPMISSIQKIALYETKSRFYLMGSNNNLTRFRVLKIDRMEPRDLVVVDDKMEYTQDEIADLVTMIDIGNRSSNNSGNSKLIGQRNKASGVARIVSAFGIVDKKQQYNLIYHKPTKTNFSWKSTWNKDCFPRLISAFGIVGFVRFLEGYYIILVTKRRRVAVIGHHTIYKIEDTSMIYIPNDTVRIFHPDEQRYVKMFQSIDLSSNFYFSYSYDLTHTLQNNLAPPKHIFNNNNNNTDINDSQDEDNPDEKLINMWTQMTFKNKKIIDYGVRSNPNRRFVWNNHLLNPVERDLHRDWILYITHGFIGQSNVCIFGKSIYITLIARRSNKYAGTRFLKRGANSTGDVANEVETEQIVYDSAVSSLHSGRFTSFVQMRGSVPGNWSQDISKMVPKPTISCDLADPFYEIAGAHFNQLLQRYGTPTIILSLVKKREKKKHESTLSDELTSAVKYLNQFLAPENQLQYVSFDMARMNKGKEAKVMSRLANIANNAVIKTGIFQSQVPYYSQKKLFLDNTPVVRNCKLNEEGYDKITESFIKKGTLQTGIIRTNCVDCLDRTNTAQFAIGKCALGYQLCALGVLDSAKLEFDSDCVRMLEELYEDHGDTLALQYGGSQLVHRIKTYRKTAPWTSQGNDIMQTLSRYYSNTFSDQEKQHTINLFLGLFTPEEGRVPLWELLTDYYLHHTPVFRRTKLLTQWWDKNTIRCLPYAYDDIEKTCWEMVQVDSTQEEMIDVYSDYHRLYELVPLSEMYAYQISHSIRDFMPHFTTNYSPFAVRVRPGRRREETGNKRNGNIKNPSMTGQSSTSSTASSASSSVDTSSDDEDDDLVVVRHQRSDLSNRDSRETNASSVSFEALFPAMKEVYGVELENPRRSDLVLYKRFVMIGRNAAGVKEHTSSIQRAKMVQQVTFPDIVNLSRKKTESFKLPKVDDTSVSIYEQYVQRGKNGGFIPNPTDMILYEKYTYESKLCHDTNFKTIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H6U3</accession>
    <name>A0A8J2H6U3_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Similar to Tret1-2: Facilitated trehalose transporter Tret1-2 homolog (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HICCMSTLAB_LOCUS2935</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001117">
        <property type="protein sequence ID" value="CAG5079139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H6U3"/>
    <dbReference type="OrthoDB" id="4142200at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000218">
        <property type="entry name" value="facilitated trehalose transporter Tret1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050549">
        <property type="entry name" value="MFS_Trehalose_Transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48021">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48021:SF1">
        <property type="entry name" value="GH07001P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="24"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="63"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="106"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="134"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="211"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="253"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="277"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="319"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="350"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="382"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="1"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAG5079139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="428" mass="47054" checksum="DF65D9297D270B04" modified="2022-05-25" version="1">MALVPEIIVFNEENVKPKRLNQHISAIIISFSGFALGVTIGWNSSAGDTLRNVLNATATEIGLVGGIVNAGACAGRFLCGLAGGTCCVLSPIFISEVADKNTRVRLLVYFQLLINCGIFYAFLVAYFYDEKDAIWRYSMICGVSCALIIWIAFLPETPLYYLSINDEHSAIKSINWYYGNGSNNDLNEYKKLIKSKNPVSKVLKNFNVIRAIIVCHGVIIIQQLSGINTLTFYATVIFNNGGSGELTGAQQTLVIGGLQIISCIFCMLVIDFWGRRILLAVSGIIMGLSMILFGWYINVRDEDPEFYEESYGWIPPTCMVIYFSAFNLGLGPISWSILGDTFPIEIKTFGASSVAFLSWLISLIATLTFGELAQSLGISKTMWLFGGFCCLGAILCGAFVRETRGMSLADIQNKFKIDPIQVDNNLES</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H823</accession>
    <name>A0A8J2H823_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Endonuclease/exonuclease/phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS2992</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001117">
        <property type="protein sequence ID" value="CAG5079359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H823"/>
    <dbReference type="OrthoDB" id="6755785at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5079359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="130" mass="15488" checksum="C020CD20A89D232A" modified="2022-05-25" version="1">MNGNKGGKEGGNWTFNRGETNSVIDYVVTNVESWGKVEKFEVGLRLESDHQPITTVIRRKEGDLRRIEEAERIQHRWTQCWGEKKRKIFEEREEKLNWLEKMGEEKWIELKKGVKECMVIKKREPKEKGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H8G3</accession>
    <name>A0A8J2H8G3_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS4185</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5084732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H8G3"/>
    <dbReference type="OrthoDB" id="7701306at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5084732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="117" mass="13507" checksum="088FC7962F17DD2A" modified="2022-05-25" version="1">MKEGVDWKSEVEKVWDKMEVGSGKKSMRKIGGLDKEGKGLVLIEMEGTDKKKEVMIAKKDDLTYEERRIKKIISQEAAKERAYGNTVKVGYLKMWVNGKLRLWDEAKGNWKNQQGNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H8W1</accession>
    <name>A0A8J2H8W1_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Similar to CYP4FQ7PARTIAL</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">HICCMSTLAB_LOCUS3953</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="2">May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Endoplasmic reticulum membrane</location>
            <topology evidence="4">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Microsome membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5083866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H8W1"/>
    <dbReference type="OrthoDB" id="7863685at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050196">
        <property type="entry name" value="Cytochrome_P450_Monoox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24291:SF189">
        <property type="entry name" value="CYTOCHROME P450 4C3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24291">
        <property type="entry name" value="CYTOCHROME P450 FAMILY 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0349">Heme</keyword>
    <keyword evidence="11" id="KW-0408">Iron</keyword>
    <keyword evidence="13 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0492">Microsome</keyword>
    <keyword evidence="12" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="15">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CAG5083866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="128" mass="14784" checksum="F2DBDE6AA0F93A2F" modified="2022-05-25" version="1" fragment="single">MILTLSYIITSVLFSVVFLLTIVHFYVHLRIQGRLCNLIPGPKSYPIIGNLLDLAGHPEDIWNFLHRTSIKYYPVWKIWAGIWPVVTIHHPDDAQILLNSIKHLDKSIVYDLLHPWLQDGLLTSTGKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H9H2</accession>
    <name>A0A8J2H9H2_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Gustatory receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS4025</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5084135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H9H2"/>
    <dbReference type="OrthoDB" id="10301798at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="155"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="183"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="269"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="313"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5084135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="410" mass="47187" checksum="9883541A86F9453E" modified="2022-05-25" version="1">MAQGFVNRNALTKSLSNMSIGILGLLYFILFKSIGLLPWHFNYMKLFKWNPALYYYNYGFSTSLLGTYWSVLYSLGLAYVDYCYMVYYPKVLPKKIGVMIVREQKLLQCASLGIVGITMIIYGCRQSTLINPLNEVQEIDDRLMKITGRKVKNGCSAYCVMIANLVVCAGVSVAKYIELDGKPFFQFFMTVYPCLFSNFLVLQYVMSLDVVIKRFIQLHYAIVKVDNDDVANLKSLQKRKQRINNASRQRRILFVSNILEDLDDIRLDVLWFFSPQLGIAIINMTGIAAVVGYDINQMWKGNATLQPMELFMYGLWYATVILVLLVLIIYYSLAKIAVIKFDLDDIIFGQWIESDFVFQEKWTRYKLWLITDFSLLALADGAKMEEGLRNQAQERLEGDGDLQSLDVTFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H9J8</accession>
    <name>A0A8J2H9J8_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS5028</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5088924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H9J8"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5088924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="147" mass="16318" checksum="C65508E61885CCF9" modified="2022-05-25" version="1">MKIISSARIKRFDCNTLTEDSILNGIAIVPGRLPEDIEISKAAEDLLKKILNPDPRARFYWFKSVIISENSSVVRLLGSLLRLALVSAKGSFNTLARLRRNLLSATRTPIVSIPGFSFGFKLPVRLTTMVTCPGKSVSRRSGRIWST</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H9N4</accession>
    <name>A0A8J2H9N4_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similar to RTTN: Rotatin (Homo sapiens)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS4726</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5088137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="428850at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005814">
        <property type="term" value="C:centriole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007099">
        <property type="term" value="P:centriole replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010457">
        <property type="term" value="P:centriole-centriole cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032053">
        <property type="term" value="P:ciliary basal body organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030791">
        <property type="entry name" value="Rotatin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029249">
        <property type="entry name" value="Rotatin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31691">
        <property type="entry name" value="ROTATIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31691:SF1">
        <property type="entry name" value="ROTATIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14726">
        <property type="entry name" value="RTTN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rotatin N-terminal" evidence="1">
        <location>
            <begin position="21"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5088137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="2020" mass="230164" checksum="AB994E6249D71E6F" modified="2022-05-25" version="1" fragment="single">MSITNAITSVHVDKLNHNLEEIRLRALDNIIAKLNHGFGCDCDSVKRELVSKLFNWFTFDTIPHPDKVLNLIHQLITTNVINPSIFGKLRFQNELGQLRKRLDSAWHDKLYEIEEAVLQHASPALETMGNNDLRSSAGDITNRKTVTENNIQKTDCNIKNNEFVNHEYDKIQDNFINHSTESLNDTIQLDLTIPSDTGTPLSRKTERAIRWLVMPWQPLVSSDRGVLSAIEEALNNSADIGLIVRTCEFITNVMLQDFPAEVFLQRPSIVTILQNLLETCIQDPKVDACHLIPVILRTFNKLTRSLRFRIYYYCDPSIANRRQKNLSGQLDSSCQSLEDRESSESGLPEANYQAYQSAVMSDRSQSVADNVDESVLQLQQMLIPNFCIQVFTSTLKLLTIYDDSLRPLKDIKNILDLTWELVQLLILSVMPNIWFSTDQLSLKIHENLKFIMKLLGDVLEYCRSYSTADHWRITYLRLLCIVTKLLSSLVPLELAEYIIPSALKTALCVGVMDAPIYFMYPDLNIILQEYTRRFQGTVEIQYLKLFDETRLITKSMKAAISILKLNFNHDHLTIDTLRTMYSSKSCLIYHKNLSIIKKYIFLMQNLYHMKLDKENKTIAVKLILYLLANEDEEIRVNTYEECHWLVSSTLGIETARGRYNWTSVAFLFEPSLLIEIICHGVADEKTKSLAEDILLYILKGKLQMGDGWLVFLEALIQVLPLLQCLAEMKSSLGQCLSKMLDPDIATSIQLPFLEVLKGNARYLFSRDGAIREEAACRLIYLLGTEKNSSNKLPQLASLHGLPLGSLLIVDRQGSLKKTEGSYQRSSLLSVIEMLKSPNVEPKVRKSALVQISVMLTDSSLHKLFLKENGLKIILDIFDKALIEKDYDNYPDSVIPILTILKLISSTQCTVRHELSTNTDVFINVMRSLFLFPNHECVKLDVSYLLFILLYSEFMMRLNNNDGSNLNYSLPYMVIAKMHSPIISKTHWKSSIHRKSDTSLLYSSNSLALTFIRQYWAWEWNNGTEMLWTPWSNLNDSGILSNLMIKEPELALLKYSSIRYYCSQQLINIKNSSAHEEVMYAIDYLWMYIRLCSCLQFMHIRELTSLPWESTFERFLLSHPMSKEDCDLFVDVLNFLYIHINVTHDPEVIGWLSKTLKNITKSLADLLQSLDTHNQDVHQSVLKLVRSCSSLEKLQQPQDLSSDMWNDYIELVITNLCSSDQQHFYNLVYLDWLLTCLTYLTSKSHYNCSTDLLLSSGDALIELIISFHGNGAISFMGLSITRNSIICLNHLLHHMQASLSKINWTNYWFGEGKTLSWLPTLWKNRDPLVRASALQLLAGLVKAPHIAQQLLNGLAMAPSELCQTLLKFIINHEESSIVREYACIIMSNLIKNNSIGDNFPQFLSTPSLITSVCTFLNNLINVGERDVINKIYEHSLDKYLLGCFGSIPKINKMKKYKSIRQCYDIIEMYINICILLTNCVKSCNNFATVVNFSPDFLYLLFNYLDKNNLNQDNSKLVDLHNKLSTQVFNFLSILSLTENQHVESLRTAIEIAAPEMVIKSICNAINHSDVELRMSGVACLAFLLSQEIAREDQIKCGIPSLGAVLDSTFTHTINHQTDSNLREVLSDVNKLALKTSSKHSKTFYNSDDGGCTDSNESQKCIPIGSELCKSLIHLLIAHNYAKSNTNTKRARDKDLIIAALSNLLCVSDKAKNTALEDNLAGTCILILKELYYELNLHPHHVHRTQLERDKRALPIYYTNCGRGFHSTIQRFCRPAQSLTLTTTLPGTGPRKTPNTVSLIHIIVHLVSKEIDKAGQSYNNQRLRFSFHVLKNAVHAHDCRVSISKSNLLQFLTKIHPSSTKRAKPWPLIEIYCLEFLVDFTFFEEGQISVSKAVEGLEVLIQLSRCNTPATRILALSTLRNLLFNFSNRPRILCSVEFMNLLHTVFKSGSLCEIGIAGSMLWSLIANSQKGKLIARSTGLPNSIQKVLGRLTLKPEEKNDQDLVRMLQYIIRVLSAWSGTNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H9X6</accession>
    <name>A0A8J2H9X6_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Nitric oxide synthase</fullName>
            <ecNumber evidence="12">1.14.13.39</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">HICCMSTLAB_LOCUS5143</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Produces nitric oxide (NO) which is a messenger molecule with diverse functions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>2 L-arginine + 3 NADPH + 4 O2 + H(+) = 2 L-citrulline + 2 nitric oxide + 3 NADP(+) + 4 H2O</text>
            <dbReference type="Rhea" id="RHEA:19897"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16480"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:57743"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.14.13.39"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="12">Binds 1 FAD.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
        <text evidence="12">Binds 1 FMN.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 12">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the NOS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.13.39" evidence="12"/>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5089207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H9X6"/>
    <dbReference type="OrthoDB" id="1688044at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004517">
        <property type="term" value="F:nitric-oxide synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006809">
        <property type="term" value="P:nitric oxide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903522">
        <property type="term" value="P:regulation of blood circulation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00795">
        <property type="entry name" value="NOS_oxygenase_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.440.10:FF:000001">
        <property type="entry name" value="Endothelial nitric oxide synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.990.10:FF:000002">
        <property type="entry name" value="Nitric oxide synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.360:FF:000033">
        <property type="entry name" value="Nitric oxide synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.80:FF:000003">
        <property type="entry name" value="Nitric oxide synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.990.10">
        <property type="entry name" value="NADPH-cytochrome p450 Reductase, Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.340.10">
        <property type="entry name" value="Nitric Oxide Synthase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1230.10">
        <property type="entry name" value="Nitric Oxide Synthase, Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.440.10">
        <property type="entry name" value="Nitric Oxide Synthase,Heme Domain,Chain A domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003097">
        <property type="entry name" value="CysJ-like_FAD-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001094">
        <property type="entry name" value="Flavdoxin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008254">
        <property type="entry name" value="Flavodoxin/NO_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001709">
        <property type="entry name" value="Flavoprot_Pyr_Nucl_cyt_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023173">
        <property type="entry name" value="NADPH_Cyt_P450_Rdtase_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050607">
        <property type="entry name" value="NOS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044943">
        <property type="entry name" value="NOS_dom_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044940">
        <property type="entry name" value="NOS_dom_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044944">
        <property type="entry name" value="NOS_dom_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012144">
        <property type="entry name" value="NOS_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004030">
        <property type="entry name" value="NOS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036119">
        <property type="entry name" value="NOS_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43410:SF1">
        <property type="entry name" value="NITRIC OXIDE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43410">
        <property type="entry name" value="NITRIC OXIDE SYNTHASE OXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00667">
        <property type="entry name" value="FAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00258">
        <property type="entry name" value="Flavodoxin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02898">
        <property type="entry name" value="NO_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000333">
        <property type="entry name" value="NOS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00369">
        <property type="entry name" value="FLAVODOXIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00371">
        <property type="entry name" value="FPNCR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="Flavoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56512">
        <property type="entry name" value="Nitric oxide (NO) synthase oxygenase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50902">
        <property type="entry name" value="FLAVODOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS60001">
        <property type="entry name" value="NOS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12" id="KW-0112">Calmodulin-binding</keyword>
    <keyword evidence="7 12" id="KW-0274">FAD</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5 12" id="KW-0288">FMN</keyword>
    <keyword evidence="3 12 13" id="KW-0349">Heme</keyword>
    <keyword evidence="11 12 13" id="KW-0408">Iron</keyword>
    <keyword evidence="6 12 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 12" id="KW-0521">NADP</keyword>
    <keyword evidence="10 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavodoxin-like" evidence="14">
        <location>
            <begin position="473"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="15">
        <location>
            <begin position="719"/>
            <end position="964"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="13">
        <location>
            <position position="125"/>
        </location>
        <ligand>
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR000333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR000333-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CAG5089207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="1149" mass="130268" checksum="1B8AB276F1548F56" modified="2022-05-25" version="1">MKDQQETGAQKKATKLRNLTHKTEAFDLLHPKGIEKTLCSGQVCLGSVMSLPFHGTEARKKEEILIHAKDFLEQYFASIRRSNSEAHRSRWESIQREVLSTGTYQLSETELVFGAKLAWRNAARCIGRIQWSKLQVFDCRYVTTTSGMFEAICNHIKYGTNKGNIRSAITVFPQRTDGKHDYRVWNSQLISYAGYKNKDGTILGDPANAEFTDLCFKLGWRGPRSGVRTRFDILPLVLSANGHDPDYFDIPSELVLEIPIKHPTYEWFEELHLKWYALPAVSSMVFDCGGLEFTAAPFNGWYMSTEIGARDLCDTTRYNLLETIAVHMGLDTRTPITLWKDKAMIEANVAVIYSFQIKNVTIVDHHTASESFMKHYENEMRLRKGCPADWLWIVPPLSGSITPVFHQEMALYHLKPSYDAQDPAWKTHIWKKGRDKKATSKKPRRKFHFKQIARAVKFTSKLFGRALSRRIKATVLFATETGTSQMYAEKLGELLGHAFHSQVLSMAEYDISNIEHEALLLVITSTFGNGDPPENGEAFAQNLYAMKMNETYNNNNNESKITLATSKSFIKANSQTEVGSVKKLDRLDSLRGSTTESQNEDTFGPLSNVRFAVFALGSSAYPNFCAFGHYVDNLLGELGGERLLKLSQGDEMCGQEQAFRKWAADTFAVACETFCLDDDDTLLEVALSLGSEALSRSTVRFIEADPQPIAKALSKCHNRNVTTCNMLRKTNLSGNDSGATTLLLELDDLAGMEISYKPGDHLGVFACNKSELVEGILARLEPTLDFDTPMELQTQKQSHTPNGVVKTWVPHERFSPNALRMLLTRFLDITTPPTPNLLRYFSSIAENPKEKNQLNLLATATYEDWKHWKYPNLLEVLEEFPSIKPYAPLFVLHLTPLQPRFYSISSSPLVHQGQIHLTVAIVQYKSQGGTGPIHYGVCSNYLNEITDGEPLYVFVRSAPNFYMPPDVSAPMILVGPGTGIAPFRGFWHHRYAQMQMQIRENFGKIWLFFGCRQKNIDLYCQEKREMMEAGVLDNVFLALSREKGIKKTYVQDLILAESLQIYNMLVHENGHFYVCGDCTMAEDVYQTLKHIIQTHGQLSDKEVEAYMLSLRDQTRYHEDIFGITFRTAEVHNRSRETARIRLATEPVST</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H9Z7</accession>
    <name>A0A8J2H9Z7_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Similar to csgA: C-factor (Myxococcus xanthus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HICCMSTLAB_LOCUS5188</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5089313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H9Z7"/>
    <dbReference type="OrthoDB" id="5296at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004090">
        <property type="term" value="F:carbonyl reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05325">
        <property type="entry name" value="carb_red_sniffer_like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051468">
        <property type="entry name" value="Fungal_SecMetab_SDRs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43544:SF7">
        <property type="entry name" value="NADB-LER2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43544">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE/REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG5089313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="266" mass="28690" checksum="489EB15E4955604C" modified="2022-05-25" version="1">MIHVHGIFTSQRYAAQQLNIKMRSILITGCNRGLGLGLVQHLTQLPNPPEKIFATCRDINKAQKLKEIAEKSSNVCIIKADLTNFKDYDRIVNEVSAQVGDAGLNVLFNNAAILLPSSKLDSVKAEDLTENYLVNTVVPIMLTKAFLPLLRKAAAGKQGMSVDRAAVINMTSLMGSIADNGSGGSYPYRCSKAALNAATKSMSVDLKEDGILVACMHPGWVKTDMGGSSAPMDIDSSVHNMVQTVMGLSEKDNGAFLRHDGTILPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HA73</accession>
    <name>A0A8J2HA73_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS4924</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5088648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HA73"/>
    <dbReference type="OrthoDB" id="7701150at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5088648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="136" mass="15120" checksum="A77722F40A6F5DFD" modified="2022-05-25" version="1">MAKINNYTCAVASWLVFVFVINSKAYADLSSSLIPLVPVVDPTSNTTASSPLVASLLPVAVESVPPTSTPADSDESNEFDESNSSSAEIKDDMDVAEDIIFRPLFRYRQEVADRQQSRKYYQPYLLIIKIKLEKII</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HA96</accession>
    <name>A0A8J2HA96_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Globin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HICCMSTLAB_LOCUS4969</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the globin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5088754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HA96"/>
    <dbReference type="OrthoDB" id="436496at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019825">
        <property type="term" value="F:oxygen binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005344">
        <property type="term" value="F:oxygen carrier activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01040">
        <property type="entry name" value="Mb-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.490.10">
        <property type="entry name" value="Globins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000971">
        <property type="entry name" value="Globin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050532">
        <property type="entry name" value="Globin-like_OT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009050">
        <property type="entry name" value="Globin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012292">
        <property type="entry name" value="Globin/Proto"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044399">
        <property type="entry name" value="Mb-like_M"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46458">
        <property type="entry name" value="BLR2807 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46458:SF1">
        <property type="entry name" value="GEO09476P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00042">
        <property type="entry name" value="Globin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46458">
        <property type="entry name" value="Globin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01033">
        <property type="entry name" value="GLOBIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0349">Heme</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 6" id="KW-0561">Oxygen transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Globin" evidence="7">
        <location>
            <begin position="23"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS01033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG5088754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="180" mass="21038" checksum="FFB0916C06478413" modified="2022-05-25" version="1">MSHLFSDNISPADSEKIGPRISGFTQKQKKYMKNTWDEFVFKNLTAIGAEAMMSVFENNNDIKEMFPAFKKIPIDQLKHNEKFNAHCKMIMNVLNKALNAFFDDNDELFEKIVKIIGERHAMWAKNPIIIKQFQCVQVPLIDSLKIRLESQWTEETANLWTYAVEKVFRAMIVPMKEVFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HAK1</accession>
    <name>A0A8J2HAK1_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Similar to DDR2: Discoidin domain-containing receptor 2 (Homo sapiens)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">HICCMSTLAB_LOCUS4134</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5084546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HAK1"/>
    <dbReference type="OrthoDB" id="6071166at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048680">
        <property type="term" value="P:positive regulation of axon regeneration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00057">
        <property type="entry name" value="FA58C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.260:FF:000007">
        <property type="entry name" value="Discoidin domain receptor tyrosine kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.1190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048525">
        <property type="entry name" value="DDR1-2_DS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000421">
        <property type="entry name" value="FA58C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24543">
        <property type="entry name" value="MULTICOPPER OXIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24543:SF291">
        <property type="entry name" value="SMOKE ALARM, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21114">
        <property type="entry name" value="DDR1-2_DS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00754">
        <property type="entry name" value="F5_F8_type_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00231">
        <property type="entry name" value="FA58C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01286">
        <property type="entry name" value="FA58C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50022">
        <property type="entry name" value="FA58C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10 15" id="KW-0675">Receptor</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="406"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="domain" description="F5/8 type C" evidence="14">
        <location>
            <begin position="25"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="15">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00061639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CAG5084546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="634" mass="71559" checksum="F5DFAAAC3B5DBA85" modified="2022-05-25" version="1" fragment="single">MRLNDNKVDFMSVRKIIIVREPPQCINPLGMESGAISDADITASSSFDSGNVGPRQSRLRTENHGGAWCPKDEITSEPREWLEIDLHSVHVITGTNTQGRFGNGLGVEYAEGYLLEYWRPRLGKWVRYRDIKGKEILKGNTNTYLENKHELDPPLWASKIRFFPYSNHRRTVCMRVELYGCLWTDGIVAYSMPQGDTRGNEWEFFDASYDGHWDGELRRGLGQLVDSKIGPDNFKMGYYDSARSQGWVAWRNDTRANEPIEIKFEFDTVREFAAVHLYCNNQFSRDVQVFSQVDVLFSIGGTYFSGEPIVYTYMEDKIFETSRNITIKLHHRVGKFIILRLHFSSKWIMLSEVIFDSDIAHGNFTPEEFVTTDLSSLPDEFFINNKNAVSDSELPVLTAQHDDPTYMAVVIGVLTAIILLLAVAIFFIVSRHRQRKCFASPVAVKVPSHLGSTCATVEKGAALMAYTLEEDEGRYAGGGTTSTLPRELDNRLLDLVKLDEYQEPYQALKYAPYYSYSTIIMEMKDMMLNNMGTGINYAAVPEVVTVPLLNPEGTFSTHEIPSSSVSSVSASDDQDIPLFPRHRLRMLSKLAEGAFGSVYVAEAEGIPEYGTNSNTLGKRLVAVKFLLPDASEKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HAR3</accession>
    <name>A0A8J2HAR3_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="21">Calcium-transporting ATPase</fullName>
            <ecNumber evidence="21">7.2.2.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">HICCMSTLAB_LOCUS5346</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="21">Catalyzes the hydrolysis of ATP coupled with the transport of calcium.</text>
    </comment>
    <comment type="function">
        <text evidence="20">This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19 21">
            <text>Ca(2+)(in) + ATP + H2O = Ca(2+)(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18105"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.2.2.10"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="21">Membrane</location>
            <topology evidence="21">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Sarcoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="18 21">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="23">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.2.2.10" evidence="21"/>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5089712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HAR3"/>
    <dbReference type="OrthoDB" id="3352408at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033017">
        <property type="term" value="C:sarcoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005388">
        <property type="term" value="F:P-type calcium transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd02083">
        <property type="entry name" value="P-type_ATPase_SERCA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000143">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000003">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000005">
        <property type="entry name" value="Calcium-transporting ATPase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1110.10:FF:000065">
        <property type="entry name" value="Sarcoplasmic/endoplasmic reticulum calcium ATPase 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006068">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005782">
        <property type="entry name" value="P-type_ATPase_IIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01116">
        <property type="entry name" value="ATPase-IIA1_Ca"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42861">
        <property type="entry name" value="CALCIUM-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00689">
        <property type="entry name" value="Cation_ATPase_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08282">
        <property type="entry name" value="Hydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00120">
        <property type="entry name" value="HATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00831">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 21" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10 21" id="KW-0106">Calcium</keyword>
    <keyword evidence="5 21" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="16 21" id="KW-0406">Ion transport</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="17 21" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 21" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0703">Sarcoplasmic reticulum</keyword>
    <keyword evidence="14" id="KW-1278">Translocase</keyword>
    <keyword evidence="6 21" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="15 21" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 21" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="60"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="84"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="260"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="292"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="760"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="834"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="870"/>
            <end position="892"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="941"/>
            <end position="960"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase N-terminal" evidence="22">
        <location>
            <begin position="3"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00038148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00048694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00054278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="RuleBase" id="RU361146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="SMART" id="SM00831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="CAG5089712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="962" mass="105770" checksum="3BDA40C115ADF3DF" modified="2022-05-25" version="1">MEDAHCKTVDEVLNYFNCDQEKGLSPDQVKRNQEKYGLNELPAEEGKSIWQLVLEQFDDLLVKILLLAAIISFVLALFEEHDDAFTAFVEPFVILLILIANAVVGVWQERNAESAIEALKEYEPEMGKVVRADKSGVQRIRAKEIVPGDIVEVSVGDKIPADIRLIKIYSTTLRIDQSILTGESVSVIKHTDAIPDPRAVNQDKKNILFSGTNVAAGKARGVVMGTGLNTAIGKIRTEMSETEEIKTPLQQKLDEFGEQLSKVITVICIAVWAINIGHFNDPAHGGSWIKGAIYYFKIAVALAVAAIPEGLPAVITTCLALGTRRMAKKNAIVRSLPSVETLGCTSVICSDKTGTLTTNQMSVSRMFVFERIEGNDSAFNEFEITGSTYEPIGDVYLKGSKIKGADYEALHELGTICIMCNDSAIDFNEFKQAFEKVGEATETALIVLAEKINPFGVPKTGLDRRTAAIVVRQDIETKWKKEFTLEFSRDRKSMSSYCVPLKPSKLGTGPKLFVKGAPEGVLDRCTHARVGTSKVPLTSTLKNRILDLTRQYGTGRDTLRCLALATADHPMKPDEMDLGDSNKFFMYEKDLTFIGVVGMLDPPRKEVFDSIVRCRAAGIRVIVITGDNKATAEAICRRIGVFTEDEDTTGKSYSGREFDDLPIAQQREACSRARLFSRVEPSHKSKIVEYLQSMNEISAMTGDGVNDAPALKKAEIGIAMGSGTAVAKSASEMVLADDNFSSIVAAVEEGRAIYNNMKQFIRYLISSNIGEVVSIFLTAALGLPEALIPVQLLWVNLVTDGLPATALGFNPPDLDIMDKPPRRAGESLISGWLFFRYLAIGGYVGAATVGSAAWWFILSENQSLITMPPWSNMWLIASMALSFTLHFVILYVEVLSSVFQVTPLSGDEWMTVMKFSIPVVLLDETLKFVARKITDGENPIYTIHGIILMWAVFFGLLLYGPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HBX0</accession>
    <name>A0A8J2HBX0_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Metalloendopeptidase</fullName>
            <ecNumber evidence="10">3.4.24.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">HICCMSTLAB_LOCUS6360</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="9 10">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="9 10">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="10"/>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5092767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HBX0"/>
    <dbReference type="OrthoDB" id="7694278at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00041">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.290:FF:000013">
        <property type="entry name" value="Membrane frizzled-related protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.290">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000859">
        <property type="entry name" value="CUB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001506">
        <property type="entry name" value="Peptidase_M12A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006026">
        <property type="entry name" value="Peptidase_Metallo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035914">
        <property type="entry name" value="Sperma_CUB_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127">
        <property type="entry name" value="DISCOIDIN, CUB, EGF, LAMININ , AND ZINC METALLOPROTEASE DOMAIN CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127:SF861">
        <property type="entry name" value="DORSAL-VENTRAL PATTERNING PROTEIN TOLLOID-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01400">
        <property type="entry name" value="Astacin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00431">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00480">
        <property type="entry name" value="ASTACIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00042">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00235">
        <property type="entry name" value="ZnMc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49854">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51864">
        <property type="entry name" value="ASTACIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01180">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="4 9 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 9 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 9 10" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2 9 10" id="KW-0645">Protease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5 9 10" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M12A" evidence="13">
        <location>
            <begin position="39"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="12">
        <location>
            <begin position="242"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="12">
        <location>
            <begin position="356"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="134"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="133"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="137"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="143"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="103"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="105"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="242"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CAG5092767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="473" mass="54235" checksum="EAE4F41920301000" modified="2022-05-25" version="1">MGLIFQIFVIQIFFIQLFVVYSYLITDTHEFFERSRRTVAIKNEEKLWDHGIIPYEIDYVFSETQRKTIKQAIREWERSTCIKFVKRNRKIKTNYLKFTRLNCGCCFAQSSSSKYLKFISISNNCDSLVVLLHELGHAIGFDHEHKRPDRDEYVQIIHQNILADKLTEFDKLAPNLVNTFNQTYDYYSVMHYPGDSYSKYEHRDTIIPTSKIGNNPLPIGGGIKLSFGDIVTTNLLYQCPKCGGTLLDPKGIFGPPISQNKLLVNANRCEWRIQAAAGEKIELHIKDMNIHESPGCLVDYLEVKNGYEAGDIVMNRYCGKMEEINLIATNFLQVTYVKTSDKNIVNAFNVDYETVCGGYFDVKSDAILRIESTNYPDKYPPNTRCIWHLTAPDNHLITMKVNDLALERSKGCLNDFLEIRNGNIYSQPIGNYCGIENSLLINSTENKVSIIFISNDVEEDMGFSAVFLAIPNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HCX1</accession>
    <name>A0A8J2HCX1_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Similar to PXMP2: Peroxisomal membrane protein 2 (Bos taurus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HICCMSTLAB_LOCUS5207</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the peroxisomal membrane protein PXMP2/4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5089364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HCX1"/>
    <dbReference type="OrthoDB" id="860at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007248">
        <property type="entry name" value="Mpv17_PMP22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11266:SF80">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11266">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN 2, PXMP2 MPV17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="58"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="89"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="117"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAG5089364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="145" mass="16577" checksum="5BD6266BF01EC477" modified="2022-05-25" version="1">MSLSKPSEIAFNLVASYMNNLYNNPIKTKAITSCVIATLGNYIAQKTQGVKEIDHDTLASYGIFGLLFGGTVPHFFYKIIYKYLKNPLAILMIERLLYTPCFQVLALYMLARFELKVLVVNFIGLAWTVYLANVRARDARRQRRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HDC2</accession>
    <name>A0A8J2HDC2_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Similar to LCC5: Laccase-5 (Trametes villosa)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HICCMSTLAB_LOCUS5271</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the multicopper oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5089526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HDC2"/>
    <dbReference type="OrthoDB" id="2121828at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13858">
        <property type="entry name" value="CuRO_1_tcLCC2_insect_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13884">
        <property type="entry name" value="CuRO_2_tcLCC_insect_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13905">
        <property type="entry name" value="CuRO_3_tcLLC2_insect_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000045">
        <property type="entry name" value="Laccase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000073">
        <property type="entry name" value="Laccase 2, isoform E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000031">
        <property type="entry name" value="Laccase-2 isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011707">
        <property type="entry name" value="Cu-oxidase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001117">
        <property type="entry name" value="Cu-oxidase_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011706">
        <property type="entry name" value="Cu-oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045087">
        <property type="entry name" value="Cu-oxidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033138">
        <property type="entry name" value="Cu_oxidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002355">
        <property type="entry name" value="Cu_oxidase_Cu_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709">
        <property type="entry name" value="MULTI-COPPER OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709:SF232">
        <property type="entry name" value="STRAW, ISOFORM G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00394">
        <property type="entry name" value="Cu-oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07731">
        <property type="entry name" value="Cu-oxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07732">
        <property type="entry name" value="Cu-oxidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00079">
        <property type="entry name" value="MULTICOPPER_OXIDASE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00080">
        <property type="entry name" value="MULTICOPPER_OXIDASE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035213044" evidence="4">
        <location>
            <begin position="19"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="7">
        <location>
            <begin position="169"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="5">
        <location>
            <begin position="296"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="6">
        <location>
            <begin position="569"/>
            <end position="703"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG5089526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="736" mass="81776" checksum="BEC8597FE099AD85" modified="2022-05-25" version="1">MKLLGAIILTLLAVECWGTRVQSSKKKKEVAADQTAASSFWSPAIKTGNIFSQDDNSNFFSAGHGLVQTHPISSTFQSGFGGIDDLGTRGATVRPPRTRPLDYSERATAELRRNPSLSAPDECARACREGEPPRICYYHFTLEYYSVLGAACQVCTPNATNTVWSHCQCVLADGVERGILTANRMIPGPSIQVCEGDKVVVDVENHMQGMEATIHWHGVWQRGSQYYDGVPYVTQCPIQEGNTFRYQWTAGNAGTHFWHAHTGLQKIDGLYGSVIVRQPPSKDPNSNLYDYDLTTHVVLISDWMHEDAAERFPGRLAVNTGQDPETVLINGKGQFRDPNTGFMTNTPLEVFTVTPGRRYRFRLINSFGSVCPAQITFQGHELTLIATDGEPVQPVQVNTIISFSGERYDFVINADQPVGAYWIQLRGLGECGIKRAQQLGVLRYARGPYQPASQPPTYDLGLPQGVVLNPLDAICNMPRDDAVCVNQLKNAKPIDEGILQARPDVKIFLPFRFLFYRPEEVFQPNTYNRFLVAPTGDHVISLVDEISFTFPPAPPLSQIDDIPPEQFCNGDNRPADCGANCMCTHKVDIPHNAIVEVVLVDEVQQPNLSHPFHLHGYAFNVVGMGRSPDKNVKKINLKHALDLDRRGLLHREFNLPPSKDTIAVPNNGYVVFRFRADNPGYWLFHCHFLFHIVIGMNLVLHVGTHADLPPVPPNFPTCGDHLPPITPPLALDSPFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HDE1</accession>
    <name>A0A8J2HDE1_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Similar to ASB11: Ankyrin repeat and SOCS box protein 11 (Bos taurus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HICCMSTLAB_LOCUS5480</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5090076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HDE1"/>
    <dbReference type="OrthoDB" id="19174at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171:SF9">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="37"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="127"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG5090076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="180" mass="20709" checksum="B9125A5AD8DA0A4F" modified="2022-05-25" version="1">MSKKLSVDTVVRVYEKDRFKIPHLKLLPRIRPKKDFFEYTILHLALYVHDDEFVDFLLENNANTELRTEHLGPVILSAISLNRLKYVKKLIAAGADVNQIICAKDTYEEYNGRLNDEDNFNFHLDYHEYTPLEFAVNHNAYEIAEFLISQGADVQERDFNGESTDSPMGIAALANNVGML</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HEM8</accession>
    <name>A0A8J2HEM8_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS8252</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5096523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HEM8"/>
    <dbReference type="OrthoDB" id="7700553at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5096523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="389" mass="44710" checksum="CAAAED61A12649B3" modified="2022-05-25" version="1">MHVKIPGDIDNACALKVAAKAKAKTPIQPYLILVGPNALDLKKIYIQVDNHRFEASTFADGFDLLFKFYLMFKLAYPIESQHFWYFIQWGVYKIKTESDVQIPSIFTIVNKLKINLPNPGITQNLAQAIIKDFQLLMTKVSTATLKNLKQRIPAEYHELMERYFDFDIFDNFDSNWRCMQQFKASSHYVAPQQIKIGEISDNKVVDNIDVWTKKPCFGQIIPLRAHHAQVVKCRINILLTLARKLQLDLSKKFLTNEGFKNFVELGSVHPSFAFHLSNNSENNSVFGIITAILSDTKTIYFSYKKCTTIGLNTHIKAYQLIAPKAIIVYLYSTLVRAGCLYGVETWGCEKVKKIEVLQNKLDRSALGVARNTPKYIIRREIGEEEIRWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HGB6</accession>
    <name>A0A8J2HGB6_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Lysosome-associated membrane glycoprotein 5</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="19">Lysosome-associated membrane protein 5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="26" type="ORF">HICCMSTLAB_LOCUS7628</name>
    </gene>
    <organism evidence="26 27">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="26" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="16">Plays a role in short-term synaptic plasticity in a subset of GABAergic neurons in the brain.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell projection</location>
            <location evidence="4">Dendrite</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="17">Cell projection</location>
            <location evidence="17">Growth cone membrane</location>
            <topology evidence="17">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="15">Cytoplasmic vesicle</location>
            <location evidence="15">Secretory vesicle</location>
            <location evidence="15">Synaptic vesicle membrane</location>
            <topology evidence="15">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Early endosome membrane</location>
            <topology evidence="2">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum-Golgi intermediate compartment membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="20">Membrane</location>
            <topology evidence="20">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Recycling endosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 20">Belongs to the LAMP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="26">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5095276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HGB6"/>
    <dbReference type="OrthoDB" id="6232933at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072594">
        <property type="term" value="P:establishment of protein localization to organelle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12087">
        <property type="entry name" value="TM_EGFR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048528">
        <property type="entry name" value="Lamp2-like_luminal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048524">
        <property type="entry name" value="Lamp2-like_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002000">
        <property type="entry name" value="Lysosome-assoc_membr_glycop"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11506">
        <property type="entry name" value="LYSOSOME-ASSOCIATED MEMBRANE GLYCOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11506:SF35">
        <property type="entry name" value="LYSOSOME-ASSOCIATED MEMBRANE GLYCOPROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01299">
        <property type="entry name" value="Lamp2-like_luminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21222">
        <property type="entry name" value="Lamp2_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00336">
        <property type="entry name" value="LYSASSOCTDMP"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51407">
        <property type="entry name" value="LAMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0966">Cell projection</keyword>
    <keyword evidence="14" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="8" id="KW-0967">Endosome</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11 20 22" id="KW-0472">Membrane</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 23" id="KW-0732">Signal</keyword>
    <keyword evidence="10" id="KW-0770">Synapse</keyword>
    <keyword evidence="6 20 22" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 22" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="23">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035257584" description="Lysosome-associated membrane glycoprotein 5" evidence="23">
        <location>
            <begin position="27"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="289"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="domain" description="Lysosome-associated membrane glycoprotein 2-like luminal" evidence="24">
        <location>
            <begin position="111"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="Lysosome-associated membrane glycoprotein 2-like transmembrane" evidence="25">
        <location>
            <begin position="290"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="28"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="21">
        <location>
            <begin position="28"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="21">
        <location>
            <begin position="46"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="21">
        <location>
            <begin position="58"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="21">
        <location>
            <begin position="88"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00009644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00029428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00053950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00060492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00074379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00076257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="Pfam" id="PF01299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="Pfam" id="PF21222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="EMBL" id="CAG5095276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="324" mass="34733" checksum="3A86FD97545CD8F6" modified="2022-05-25" version="1">MKFSVVLFSVCLLVISVSEKTGVVEGTVIDKPEFPPEPEKNETTPAPTPTPAPPTTAPPTTTEPTTTTTEKTTTTTTPATTTSTVAPTPTPSPTPTPTPTPTPTPGPAPAPTAGTWVVNGANHTTCIMVKMAAQLNVTYLNKDNKTMHQLITLPNNTMSNATGDCGAAEQYIKISWNSSMALNDSLVLHFNKNGTKYSLHHIEANLAPQDLPSYQFNNTLMLVNNTNEYPVAVSNSYRCTKAVKLHLNSNVPNTTAVFEVSDLQFQAFRSDNTTAFGYAEDCAFETQDVVPIAVGCALIALVIIVLVAYLVGRRRSQARGYLSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HGH0</accession>
    <name>A0A8J2HGH0_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Similar to CEP20: Centrosomal protein 20 (Gallus gallus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HICCMSTLAB_LOCUS7434</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Cilium basal body</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Microtubule organizing center</location>
            <location evidence="2">Centrosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CEP43 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5094888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HGH0"/>
    <dbReference type="OrthoDB" id="5970631at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030030">
        <property type="term" value="P:cell projection organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034453">
        <property type="term" value="P:microtubule anchoring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.960.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018993">
        <property type="entry name" value="FOP_dimerisation-dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006594">
        <property type="entry name" value="LisH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15431">
        <property type="entry name" value="FGFR1 ONCOGENE PARTNER/LISH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15431:SF4">
        <property type="entry name" value="PROTEIN TONNEAU 1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09398">
        <property type="entry name" value="FOP_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50896">
        <property type="entry name" value="LISH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0966">Cell projection</keyword>
    <keyword evidence="5" id="KW-0970">Cilium biogenesis/degradation</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FGFR1 oncogene partner (FOP) N-terminal dimerisation" evidence="8">
        <location>
            <begin position="52"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF09398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAG5094888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="124" mass="14158" checksum="BEFFAF6FBFED2675" modified="2022-05-25" version="1">MTTEKDLINAVRDSLEADGKLGCIKAEMRSEVLKLLDHSSKSSRTNKCEMPSDVLLLNELIREYFDWIGYKYTLNVFMSECDSKKQSLDRSLVAQSLGIEDNEGTKKLPLLFCLTETFKKLKNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HGW5</accession>
    <name>A0A8J2HGW5_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ribonuclease 3</fullName>
            <ecNumber evidence="6">3.1.26.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="19">Ribonuclease III</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="21 22">protein Drosha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="28" type="ORF">HICCMSTLAB_LOCUS7708</name>
    </gene>
    <organism evidence="28 29">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="28" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="20">Executes the initial step of microRNA (miRNA) processing in the nucleus, that is the cleavage of pri-miRNA to release pre-miRNA. Involved in pre-rRNA processing. Cleaves double-strand RNA and does not cleave single-strand RNA. Involved in fertility. Required for the function or synthesis of the let-7 miRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endonucleolytic cleavage to 5'-phosphomonoester.</text>
            <dbReference type="EC" id="3.1.26.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the ribonuclease III family.</text>
    </comment>
    <comment type="caution">
        <text evidence="28">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.3" evidence="6"/>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5095437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HGW5"/>
    <dbReference type="OrthoDB" id="67027at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070877">
        <property type="term" value="C:microprocessor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004525">
        <property type="term" value="F:ribonuclease III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007506">
        <property type="term" value="P:gonadal mesoderm development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031054">
        <property type="term" value="P:pre-miRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031053">
        <property type="term" value="P:primary miRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19877">
        <property type="entry name" value="DSRM_RNAse_III_meta_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00593">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1520.10:FF:000002">
        <property type="entry name" value="Drosha ribonuclease III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.20:FF:000012">
        <property type="entry name" value="Drosha ribonuclease III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1520.10">
        <property type="entry name" value="Ribonuclease III domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00104">
        <property type="entry name" value="RNase_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014720">
        <property type="entry name" value="dsRBD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058938">
        <property type="entry name" value="Helical_CED_Drosha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011907">
        <property type="entry name" value="RNase_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000999">
        <property type="entry name" value="RNase_III_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044442">
        <property type="entry name" value="RNAse_III_DSRM__animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036389">
        <property type="entry name" value="RNase_III_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11207:SF0">
        <property type="entry name" value="RIBONUCLEASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11207">
        <property type="entry name" value="RIBONUCLEASE III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00035">
        <property type="entry name" value="dsrm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26050">
        <property type="entry name" value="Helical_CED_Drosha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14622">
        <property type="entry name" value="Ribonucleas_3_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00636">
        <property type="entry name" value="Ribonuclease_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00358">
        <property type="entry name" value="DSRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00535">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54768">
        <property type="entry name" value="dsRNA-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69065">
        <property type="entry name" value="RNase III domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50137">
        <property type="entry name" value="DS_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00517">
        <property type="entry name" value="RNASE_3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50142">
        <property type="entry name" value="RNASE_3_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="24" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="16" id="KW-0221">Differentiation</keyword>
    <keyword evidence="12" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="16" id="KW-0334">Gonadal differentiation</keyword>
    <keyword evidence="13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="17" id="KW-0464">Manganese</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0540">Nuclease</keyword>
    <keyword evidence="18" id="KW-0539">Nucleus</keyword>
    <keyword evidence="29" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="15 23" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RNase III" evidence="27">
        <location>
            <begin position="735"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="domain" description="RNase III" evidence="27">
        <location>
            <begin position="967"/>
            <end position="1090"/>
        </location>
    </feature>
    <feature type="domain" description="DRBM" evidence="26">
        <location>
            <begin position="1117"/>
            <end position="1192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="25">
        <location>
            <begin position="90"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="25">
        <location>
            <begin position="322"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="25">
        <location>
            <begin position="1207"/>
            <end position="1250"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="24">
        <location>
            <begin position="670"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="25">
        <location>
            <begin position="90"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="25">
        <location>
            <begin position="102"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="25">
        <location>
            <begin position="120"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="25">
        <location>
            <begin position="139"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="25">
        <location>
            <begin position="165"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="25">
        <location>
            <begin position="1232"/>
            <end position="1242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00017706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00032486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00060285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00078955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00083702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="PROSITE" id="PS50137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="27">
        <source>
            <dbReference type="PROSITE" id="PS50142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="EMBL" id="CAG5095437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="1250" mass="144678" checksum="D42F81A28CE1A8BF" modified="2022-05-25" version="1">MYPPPSFNVPPPPIVKPPIINLPASVLSTPPPVMSTPPPIINNTNYSNQYASNPYYSGYPNNYAYPYQNYPDISQGYYTAEASTNPQWKSYDSTDRWQSIPSNSTNNCSNSPADTWSSALKKDRWSNSEPLKKNYHKERKTDPQISERKSSWTSSRSPNYVSRSTSKEHRDRYNDRDGKEKYSSEETERKSRRDDSHSRSRSKDDYSSSRSSRRRSRTPESPRSASHSSKALRKKKTEREMLLEKYRRNYCATSYDIERKIDELGPEGILECDKKVWTRAAPADLYYTRDENNPKVMRATPKLKELTDNFKRSLLDRANVARAKYSPYEPPPRRTKAKLCRHKSEACSSSDSDSDSSIDDDDRTMEELMAKKQHPQRLHPEMWFNDPGEMNDGPLCRCSAKSRRSGIRHGIYAGEGSVYNCDLDSNNADKLYHYRITISPPTNFLTKTPTIIEHDEHEFIFEGFSMLSHFPLVKLPTCKVIRFNIEYTILYIEEKLPENFTINELNYFQEYLFKEILELVDFNLHSAQNYTGCGQFHFMPRFVRDLPDKGQEILSMNEVLNYLIKSSTSLIEAEELDRLIAMPQYEWQNYADLVKGMVVTYPGKKPCSVRVDQLDRTQGDQPPGITAYPEIVHFGIRPPQLSYAGNADYQKAWRDYVKFRHLLANMPKPSFEDKRKLEAKENRLQELRTQSKMKRDVTVDVSSEGFFRTGIMCDMVQHAMLIPVLVCHLRFHKSLDNLEETLKYKFKNRYLLQLALTHPSYRENFGTNPDHARNSLTNCGISQPEYGDRRIHYMNTRKRGINTLINIMSRFGARRETESSIAHNERLEFLGDAVVEFLTSIHLFHMFPDLEEGGLATYRAAIVQNQHLAVLAKKLNLEQYMLYAHGSDLCHDLELRHAMANCFEALMGSLFLDGGIHVADRVFGETLFQNEQDLGNVWVNYPRHPLQEQEPTGDRQWIPSFELLQKLTKFEKSIGIEFKHVRLLARAFTDRSIGYTNLTLGSNQRLEFLGDTVLQLIVSEYLYKYFPEHHEGHLSLLRSSLVNNKTQAVVCDDLGMTQYALYGNPKAELKTKDRADLLEAFLGALYVDKGLEFCHVFCNVCFFPRLQNFIMNQDWNDPKSKLQQCCLTLRTMDGGEPDIPVYKVIECKGPTNTRVYTVAVYFQGKRLAKASGHSIQEAEMNAAKEALENSQELFPQLDHQKRVIAKSMKMQRWPKSRDRIAEKSDDEDSGSQRRRERRRRKSRDASDDSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HH26</accession>
    <name>A0A8J2HH26_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="18">Similar to alpha-Spec: Spectrin alpha chain (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">HICCMSTLAB_LOCUS7463</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cell cortex</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the spectrin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5094946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6018565at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045169">
        <property type="term" value="C:fusome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016328">
        <property type="term" value="C:lateral plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031594">
        <property type="term" value="C:neuromuscular junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045170">
        <property type="term" value="C:spectrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051693">
        <property type="term" value="P:actin filament capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016199">
        <property type="term" value="P:axon midline choice point recognition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042062">
        <property type="term" value="P:long-term strengthening of neuromuscular junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048790">
        <property type="term" value="P:maintenance of presynaptic active zone structure"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007026">
        <property type="term" value="P:negative regulation of microtubule depolymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007274">
        <property type="term" value="P:neuromuscular synaptic transmission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11808">
        <property type="entry name" value="SH3_Alpha_Spectrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00176">
        <property type="entry name" value="SPEC"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000154">
        <property type="entry name" value="Alpha spectrin, isoform C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.60:FF:000007">
        <property type="entry name" value="Spectrin alpha chain non-erythrocytic 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.60:FF:000037">
        <property type="entry name" value="Spectrin alpha chain non-erythrocytic 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.60:FF:000272">
        <property type="entry name" value="Spectrin alpha chain, erythrocytic 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000020">
        <property type="entry name" value="spectrin alpha chain, non-erythrocytic 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000032">
        <property type="entry name" value="Spectrin alpha chain, non-erythrocytic 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.60:FF:000006">
        <property type="entry name" value="Spectrin alpha chain, non-erythrocytic 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.60:FF:000013">
        <property type="entry name" value="Spectrin alpha chain, non-erythrocytic 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.60:FF:000017">
        <property type="entry name" value="Spectrin alpha chain, non-erythrocytic 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.60:FF:000020">
        <property type="entry name" value="Spectrin alpha chain, non-erythrocytic 1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.60:FF:000035">
        <property type="entry name" value="Spectrin alpha chain, non-erythrocytic 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.60:FF:000043">
        <property type="entry name" value="Spectrin alpha chain, non-erythrocytic 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.60:FF:000078">
        <property type="entry name" value="Spectrin alpha chain, non-erythrocytic 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.60:FF:000340">
        <property type="entry name" value="Spectrin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.60">
        <property type="match status" value="18"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035825">
        <property type="entry name" value="Alpha_Spectrin_SH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014837">
        <property type="entry name" value="EF-hand_Ca_insen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018159">
        <property type="entry name" value="Spectrin/alpha-actinin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002017">
        <property type="entry name" value="Spectrin_repeat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11915">
        <property type="entry name" value="SPECTRIN/FILAMIN RELATED CYTOSKELETAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08726">
        <property type="entry name" value="EFhand_Ca_insen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00435">
        <property type="entry name" value="Spectrin"/>
        <property type="match status" value="20"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01887">
        <property type="entry name" value="SPECTRNALPHA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01184">
        <property type="entry name" value="efhand_Ca_insen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00150">
        <property type="entry name" value="SPEC"/>
        <property type="match status" value="20"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46966">
        <property type="entry name" value="Spectrin repeat"/>
        <property type="match status" value="16"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0117">Actin capping</keyword>
    <keyword evidence="12" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="10" id="KW-0106">Calcium</keyword>
    <keyword evidence="11" id="KW-0112">Calmodulin-binding</keyword>
    <keyword evidence="15" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 14" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="16">
        <location>
            <begin position="951"/>
            <end position="1010"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="17">
        <location>
            <begin position="2248"/>
            <end position="2283"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="17">
        <location>
            <begin position="2291"/>
            <end position="2326"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="273"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="1199"/>
            <end position="1226"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="1411"/>
            <end position="1445"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="1624"/>
            <end position="1683"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="CAG5094946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="2398" mass="275763" checksum="0E88A1DA4C846C3E" modified="2022-05-25" version="1">MDQITPKEVRILENPEDIQERREQVLGRYSNFKSEARSKRDKLEDSRRFQVHENYKDPTNLQAKIQKHQAFEAEVAAHSNAIVLLDNTGSEMIAQHHFSSDLIRKRLEELHRLWELLLSRLADKGLKLQQALVLVQFIRHCDEVMFWIKDKEAFVTTDEFGHDLEHVEVLQRKFDEFQKDVASQEYRVTEVNELAEKLLLDGHPERDTILSRKEELNESWQRLKQLAILRQEKLFGAHEIQRFNRDADETMTWIAEKDVVLSSDDFGRDLASVQTLQRKHEGIERDLAALEDKVSTLGAEADRLAGIHQVDHSQQIQAKRAEIIQSWESLTAKAKERRLKLDESYYLHRFLADYRDLVSWMNDMRAIISADELAKDVAGAEALLERHQEHKGEIDARADSFDAATLAGNQLLERKHYAAEEVARKLTSLAEDKSSLLTLWEKRRILYEQCMDLQLFYRDTEQADAWMAKQEAFLANEDLGDSLDSVEALIKKHEDFDKSLAAQEEKIKALDEFAGKLIEGEHYAADDVAQRRQLLLERRAVLLEKSAQRRRRLEDAYKLQQFERDCDETKGWVNEKLKFATDDSYLDPTNLNGKVQKHQNFEQELNANKTRMEEMVSTGQELIDSDHYASDRIRARTDEIVTLWESLTKASEKKGTKLQEASQQQQFNRTVEDIELWLSEVEGQLMSEDYGKDLTSVQNLQKKHALLEADVGSHADRIESISQAAEQFVSTGHFDADNIRAKQQQLQGRYSALQRPMSIRKQRLLDSLQVQQLFRDIEDEEAWIREKEPVAASTNRGRDLIGVQNLQKKHQAVLAEINNHEPRVAAVCQAGSRMLQDGHFAADEISQRLAALDEHWGQLKEKARQRKVDLDDSLQAHQYFADANEAESWMKEKRPIVLNSDYGKDEDSSEALLKKHEALVSDLEAFASTIAALREQAAACRQQETPTVEIAGKECVVALYDYAEKSPREVSMKKGDTLTLLNSNNKDWWKVEVNDRQGFVPAAYVKRVEPEAGLSASQQNLAREQSSIAARQAQIQAQYDDLLQLARERQNKLNETAKAYVLVREAAELATWIKDKENHAQVQDVGEDLEQVEVMQKKFDDFQADLKANEVRLAEMNEIAVQLMSLGQTEAALKIHTQIQDLNEKWTSLQTLTAERASQLGSAHEVQRFHRDVDETKDWIREKDAALNNDDLGKDLRSVQALQRKHEGLERDLAALGDKIKQLDEIANRLMQSHPDTADQTYVKQKEINEEWTQLTAKANSRKEKLLDSYDLQRFLSDYRDLMAWINSMMGLVASEELASDVTGAEALLERHQEHRTEIDARAGTFQAFELFGQQLLQSSHYASIEIQEKLESMAEARQELEKAWIQRRMQLDQNLELQLFCRDCEQAENWMSAREAFLSTADAVDSSDNVEALIKKHEDFDKAINAHEEKIAALQTLADQLIAAEHYAAKPIDDRRCQVLDRWRHLKDALIEKRSKLGESQTLQQFSRDADEMENWIAEKLQLATEENYKDPANIQSKHQKHQAFEAELAANADRIQSVLAMGGNLIEKHQCAGSEDAVQKRLASIADQWEYLTQKTTEKSLKLKEANKQRTYIAAVKDLDFWLGEVESLLTSEDAGKDLASVQNLMKKHQLVEADIQAHEERIKDMNGQADSLIESGQFDAAGIQEKRQSINERYERIRNLAAHRQARLNEANTLHQFFRDIADEESWIKEKKLLVGSDDYGRDLTGVQNLKKKHKRLEAELASHEPAIQAVQEAGEKLMDVSNLGVPEIEQRLKLLNQAWAELKQLAATRGQKLDESLTYQQFLAKVEEEEAWITEKQQLLSVEDYGDTMAAVQGLLKKHDAFETDFAAHGERCKETCDAGEALIKGGNHRADAIGQRCNQLRNKLEQLGGLAAKRKTRLNDNSAYLQFMWKADVVESWIADKETHVRSEEFGRDLSTVQTLLTKQETFDAGLHAFEHEGIQNITTLKERLVDSGHDQAASIQKRHADVITRWQKLLADSDARKQRLLRMQEQFRQIEELYLTFAKKASAFNSWFENAEEDLTDPVRCNSIEEIRALREAHAQFQASLSSAEADFQALAALDRQIKSFNVGPNPYTWFTMEALEDTWRNLQKIIKERDVELAKEATRQEENDKLRKEFAKHANAFHQWLAETRTSMMEGSGSLEQQLEATKRKTQEVRARRQDLKKIEDLGATLEEHLILDNRYTEHSTVGLAQQWDQLDQLGMRMQHNLEQQIQARNQSGVSEDALKEFSMMFKHFDKDKSGRLNHQEFKSCLRALGYDLPMVEEGQPDPEFENILDIVDPNRDGYVSLQEYMAFMISKETENVQSSEEIENAFRAITAADRPYVTKEELYANLTKEMADYCVARMKPYVDPKTERPITAALDYIDFTRTLFQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HHB2</accession>
    <name>A0A8J2HHB2_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cilia- and flagella-associated protein 263</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HICCMSTLAB_LOCUS8794</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the CFAP263 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5097621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HHB2"/>
    <dbReference type="OrthoDB" id="10259713at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005930">
        <property type="term" value="C:axoneme"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051885">
        <property type="entry name" value="CC_CF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025254">
        <property type="entry name" value="CCDC113/CCDC96_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15654:SF2">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 113"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15654">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 113-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13870">
        <property type="entry name" value="CCDC113_CCDC96_CC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0966">Cell projection</keyword>
    <keyword evidence="2" id="KW-0970">Cilium biogenesis/degradation</keyword>
    <keyword evidence="3 7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CCDC113/CCDC96 coiled-coil" evidence="8">
        <location>
            <begin position="191"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="104"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="231"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00044506"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00044798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAG5097621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="347" mass="40283" checksum="551E5DB969AE1CAB" modified="2022-05-25" version="1">MSSIKRASGLSFTSRTTFGIEEEPQYDDMTDEELKSCLELSIRTNRILSLENDVFERYLAHHDPQSLQTSSPVSPTSSSSIRTFSGSRGFASILTTNPSPKGLRITLSHRIEMANKEIDEMKKQLVACEKQITRKKSNFTAELEEIELRIRDIDEAKEQLEIHVVKKEADKTGKISADKFLRYIETWTKAVDRVIDKLRLKSLTIKSQIKKARLQLRQREELGETLHLIDFQALAIENEEYLKKIDDKNRQLGQLKKITGRYNIELSNCKEQLTEQQASLKNTLKEIDMPDVIDFIRVQLELEEMKKTYKRIERHKHIQKSTLRAFKKRQSRLQSIKSNTDSIKAIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HHU0</accession>
    <name>A0A8J2HHU0_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">E3 UFM1-protein ligase 1 homolog</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">E3 UFM1-protein transferase 1 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HICCMSTLAB_LOCUS10424</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="1">E3 UFM1-protein ligase that mediates ufmylation of target proteins.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UFL1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5101351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HHU0"/>
    <dbReference type="OrthoDB" id="10258297at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061666">
        <property type="term" value="F:UFM1 ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990592">
        <property type="term" value="P:protein K69-linked ufmylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032434">
        <property type="term" value="P:regulation of proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034976">
        <property type="term" value="P:response to endoplasmic reticulum stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018611">
        <property type="entry name" value="Ufl1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056761">
        <property type="entry name" value="Ufl1-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056580">
        <property type="entry name" value="Ufl1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056579">
        <property type="entry name" value="Ufl1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31057">
        <property type="entry name" value="E3 UFM1-PROTEIN LIGASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31057:SF0">
        <property type="entry name" value="E3 UFM1-PROTEIN LIGASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09743">
        <property type="entry name" value="E3_UFM1_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23659">
        <property type="entry name" value="UFL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25041">
        <property type="entry name" value="UFL1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0436">Ligase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="E3 UFM1-protein ligase 1-like N-terminal" evidence="8">
        <location>
            <begin position="8"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="E3 UFM1-protein ligase 1-like" evidence="9">
        <location>
            <begin position="457"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="domain" description="E3 UFM1-protein ligase-like C-terminal" evidence="10">
        <location>
            <begin position="579"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="334"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="334"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00030452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF09743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF23659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF25041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAG5101351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="623" mass="69896" checksum="855AD751A443D166" modified="2022-05-25" version="1" fragment="single">MSSGDWDEVKRLAADFQKAQLSSTLLKLSERNCVEIITKLIETNLLSVLFTADGKEYITPQHLEKEIRDELYMSGGRIDLVKLTKILNVDFTQVSKIATEIEKHDKGVRILLGQLIDQSYVTKIVTEINDKLNQVGHINIAELTVHYDLPADFLQSLTEKALGKSIQGQQDKQDPKFFYTDNFIARNKCKIRGALAAITIPTPLSAIIGQSNVPERIFFSIFDDLQNTGEAPAIIDQIDANIEEVIATSSFVDIYPLMPSVFSPEDIEILLKDAQKRLKKNFHIFVTTVIVSEAFLHNLNNKLESIAELKAKEAVNSGKWLQYVAESKIKANKNNDNKFESSNKKDDRRKKAASGKAGGGAQGRETKTKSTKKKYHQGKNNDNDYDSDDNKPKASDKFELILFSAQDLKIELNKYENLSDIEELVDELTNYFLVKLNKLSFKLAEQFSQATKTTNFSDVEDKLNMLITNIRIFEKGIKLIGNKDTVNSLTKYLIKTLGIDFINELLKLAAVQNILQCPTNLTTESRQKMILELPDDIKTDLENVNRAVAKGSIEDLLSSADSAMAACCLVLKKFDKKREKAVILGHKQALLEELKQTEDPALALHLTTSILFTAATQSALHMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HHY7</accession>
    <name>A0A8J2HHY7_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS8624</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5097271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HHY7"/>
    <dbReference type="OrthoDB" id="7693791at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="95"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5097271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="125" mass="14195" checksum="507166BDEBDD5A37" modified="2022-05-25" version="1">MDNSSSFQRITHSQEKMHLEKTIEAEISEDNHVSDSDDNEYFLSHETAASDCYDTADEIALNEDDEKNDVAAKGLGMRAKNGTQWAATPSSEDQISFISWLMGILKIFILYFLIQDRMRDKATPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HI27</accession>
    <name>A0A8J2HI27_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">glycogenin glucosyltransferase</fullName>
            <ecNumber evidence="2">2.4.1.186</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HICCMSTLAB_LOCUS10761</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 8 family. Glycogenin subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.186" evidence="2"/>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5101930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HI27"/>
    <dbReference type="OrthoDB" id="2014201at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008466">
        <property type="term" value="F:glycogenin glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005978">
        <property type="term" value="P:glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02537">
        <property type="entry name" value="GT8_Glycogenin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000085">
        <property type="entry name" value="Glycogenin, isoform B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002495">
        <property type="entry name" value="Glyco_trans_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050587">
        <property type="entry name" value="GNT1/Glycosyltrans_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11183">
        <property type="entry name" value="GLYCOGENIN SUBFAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01501">
        <property type="entry name" value="Glyco_transf_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="604"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="798"/>
            <end position="1109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="634"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="726"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="864"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="909"/>
            <end position="933"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="944"/>
            <end position="954"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="986"/>
            <end position="996"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="1021"/>
            <end position="1031"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="1051"/>
            <end position="1060"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG5101930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="1109" mass="122795" checksum="D91D57422CA0A05B" modified="2022-05-25" version="1">MIHTRFAWVTLVTNDSYSLGALVLAHALKRVRTKHDLAVLITPGVTAAMREKLTAVFSLVKEVNVLDSQDEANLALLARPELGITFTKLHCWRLTQYEKCVFVDADTLVIRNCDELFEREELSAAPDVGWPDCFNSGVFVFKPSQQTFASLTAFATSKGSFDGGDQGLLNLYFSDWAHKDISKHLPFIYNMCSTASYSYLPAYKQFGSEIRIIHFIGSTKPWLQYFDTQTSLVHPSSDSQHLQSLLQLWWNIFCEDVHPQLSPVMITSTLARREHNLYVSISPPSRNTISSRSIHHEYHTPTDSTYDKVDKIFDTGFYEFKDPWDSYIEPTVANNSNYSLNHPSDINVNTNSNDSVFVCEQNHEEFDKESTEIPLKNRTNFPDSMDRLCDTVEISNNNNYNNNNSNNENTSIENNYTIDIKNFNCYQIIDEILRTDNFDKKTDLSIINDNEQVQLAINNSNNSSPDQTKCNINFNREDQSNFVDKTENLVFLPTEDNKFNGHDHAYKNSVNSKPLPEPYAECKNNENESQIHCTVEVESKCAGIAGALAKITLGEARSPEQVALEEHMRRQSWEQGQIDYMGRDSFDNIWKKICTTLSIVPETQESTPKETIVADVKEKVSKPPIRKTPSTEDEPAKEVSQDVAGECHLKKSPEESKKSSEKSIQEISSPAVETSQAPNKNEPILSVTSGAPQLCIKESGETSRQPSKQEQEEKLAIALGFTTTPKDSKDKPEVKLDVSPKKSSVRTVADSPVPIQVAESVLEADIKESVSEDIKPVTEEAISSISAPIQESISTVVETPLEPPPPAQSPSVEASPLMQPNGNGLDIGLHFINAPPRAITPVSAPEPTPVRRQASIPETESKKPTGTCSRSLVGTSSSEKTEAIESESCQLTSKVSLAENVVPEQVPKTTEEVAPEPKVEEAETVIETKHSEDPQTSAIVPEEPAAKEQQRPLPKELVIPGTPTIIEATPPTSPPLDVAGCLPEPVKPEKEKPEKKVIRKIVKKSSEEKSEESEAGEAKKITKKVVKKVVKKVKDADDTGESSTAGEKPKKVVKVIKKTTKVQNLDAEASVPDTPPPASSQTPVPPKRKIKPATAKSSKKTEQDPAATP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HI83</accession>
    <name>A0A8J2HI83_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Similar to Bbs2: Bardet-Biedl syndrome 2 protein homolog (Mus musculus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HICCMSTLAB_LOCUS10851</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5102110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HI83"/>
    <dbReference type="OrthoDB" id="2120021at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034464">
        <property type="term" value="C:BBSome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031514">
        <property type="term" value="C:motile cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905515">
        <property type="term" value="P:non-motile cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016616">
        <property type="entry name" value="Bardet-Biedl_syndrome_2_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055380">
        <property type="entry name" value="BBS2_hp_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029429">
        <property type="entry name" value="BBS2_Mid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029430">
        <property type="entry name" value="BBS2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055379">
        <property type="entry name" value="BBS2_pf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028994">
        <property type="entry name" value="Integrin_alpha_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32465">
        <property type="entry name" value="BARDET-BIEDL SYNDROME 2 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32465:SF0">
        <property type="entry name" value="BARDET-BIEDL SYNDROME 2 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23353">
        <property type="entry name" value="BBS2_hp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14783">
        <property type="entry name" value="BBS2_Mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14781">
        <property type="entry name" value="BBS2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23350">
        <property type="entry name" value="BBS2_pf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69318">
        <property type="entry name" value="Integrin alpha N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ciliary BBSome complex subunit 2 N-terminal" evidence="1">
        <location>
            <begin position="19"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="Ciliary BBSome complex subunit 2 middle region" evidence="2">
        <location>
            <begin position="141"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="BBS2 platform" evidence="3">
        <location>
            <begin position="367"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="domain" description="BBS2 hairpin" evidence="4">
        <location>
            <begin position="463"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="593"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF23353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAG5102110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="593" mass="65339" checksum="567F2C6E5DA5BA1F" modified="2022-05-25" version="1" fragment="single">MAAFTLNLDRKIVPALVVCGKFDGSHACLALATSSGNILVHSPHRQPPIGVNETQEENLEKRLKWNGELAELQIGKQILSLCTGRLTEDERDILLIGTSTHILAYQVEENADLFYKNIPDGVYSIAVGKLSWLSNQVTIIDLILWEIKETAPVTALLALPGRQFAYVVDNGTVGIYESGQRLWRIKSKHKVVSIRSFDVNGDGKLELVTGWSSGKMDARSCLTGDVTFKIQLNSAVAGIVEADYRRTGRPDLVIVSVTGEVRGYGAGLMISTPEPGELIRKLLAKKQALTTELKQRGANFQNYLGSKLAVNMFPSKGAVRLALAAGPGLLISCVIVFAEGLFEGETMVVHPTRPEEELEIELKPDKNMAVDIHIAERLKRIALWLNQSFLLSKEFDVPDEGPAAAFIEIWLQGMMDNKIHCIRASAVGKASIQTEDMYFAGDIVQSLATYLGIQELGSEARFPAEEQKLCTVLERVKGLREVDARLQADAAGDSTLLKNLVIRLEDARILNDVEGMKRRLLQLKNVNSDLMRENEIRTNSSRELTSTLKELNIGVRKASRLRVGRASTNTVSRCRTAIQDENSKALIQALQNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HJU5</accession>
    <name>A0A8J2HJU5_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Similar to SLC39A9: Zinc transporter ZIP9 (Homo sapiens)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HICCMSTLAB_LOCUS11595</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5103609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HJU5"/>
    <dbReference type="OrthoDB" id="19859at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046873">
        <property type="term" value="F:metal ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006829">
        <property type="term" value="P:zinc ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003689">
        <property type="entry name" value="ZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045891">
        <property type="entry name" value="ZIP9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16133">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 39 ZINC TRANSPORTER , MEMBER 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16133:SF0">
        <property type="entry name" value="ZINC_IRON REGULATED TRANSPORTER-RELATED PROTEIN 102B, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02535">
        <property type="entry name" value="Zip"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="22"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="52"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="105"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="144"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="168"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="202"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="233"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG5103609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="306" mass="32023" checksum="3108315019939F5E" modified="2022-05-25" version="1">MFFRKLTCGRAYVFLITMDQTLVLWILAVVMLVGSYVAGSLPLVMNLSEDKLQLVSVLGAGLLVGTALAVIIPEGIRALFSGAGSVDAHTPATGHDASVDVSADLHGMIGVSLVLGFVFMLLVDQCSTRRSGGKEKSVTATIGLVVHAAADGVALGAAATTSQADVEVIVFLAIMLHKAPAAFGLVSFLLHEGVDRKKIGRHLLVFSLSAPCLALVTYFGIGKEGKETLSNVNATGLAMLFSAGTFLYVATVHVLPELMTRNSNSYSHLPVAEGTPISTSGLKFKEILALVIGSFLPALLTTGHHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HKE9</accession>
    <name>A0A8J2HKE9_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS7382</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5094056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HKE9"/>
    <dbReference type="OrthoDB" id="6612236at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="18"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="144"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="148"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5094056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="163" mass="18484" checksum="5DF3B952489A472B" modified="2022-05-25" version="1" fragment="single">KQLVLFSYCNLAHDHVRVFSSSSPSYFLFIITFKIIIKKMNKYCLVLAVSIVVVQSQRPPYAGTGDRLPAVLPQYQTSNQIQDPSEGQNVTETDNRINIQPNSPQILNLPVDAHGDVDLINRIQSWPKESQPFWYLNWKQIEEHRGGPSSVSSTSLPSTRRSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HKG1</accession>
    <name>A0A8J2HKG1_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ferritin</fullName>
            <ecNumber evidence="6">1.16.3.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HICCMSTLAB_LOCUS10795</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>4 Fe(2+) + O2 + 4 H(+) = 4 Fe(3+) + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:11148"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="1.16.3.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the ferritin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.16.3.1" evidence="6"/>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5101998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HKG1"/>
    <dbReference type="OrthoDB" id="186462at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008199">
        <property type="term" value="F:ferric iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008198">
        <property type="term" value="F:ferrous iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004322">
        <property type="term" value="F:ferroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01056">
        <property type="entry name" value="Euk_Ferritin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1260.10:FF:000002">
        <property type="entry name" value="Ferritin, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001519">
        <property type="entry name" value="Ferritin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009040">
        <property type="entry name" value="Ferritin-like_diiron"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008331">
        <property type="entry name" value="Ferritin_DPS_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11431">
        <property type="entry name" value="FERRITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11431:SF75">
        <property type="entry name" value="FERRITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00210">
        <property type="entry name" value="Ferritin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="Ferritin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50905">
        <property type="entry name" value="FERRITIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 6" id="KW-0408">Iron</keyword>
    <keyword evidence="2 6" id="KW-0409">Iron storage</keyword>
    <keyword evidence="3 5 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ferritin-like diiron" evidence="7">
        <location>
            <begin position="6"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="23"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="61"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="137"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR601519-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG5101998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="169" mass="19239" checksum="A7C030264C90FE1F" modified="2022-05-25" version="1">MSLVRQNFNADCENALNKQINMELYASYVYLSMAFYFDKSDVALQGLHQYFKLASDEEREHAMKFMTYQNKRGGSIVLTDIKSPEKVEWGSAKDAMTAALELEKKVNSSLLELHALASNHNDANLLDFLESEYLQEQVDAIKEIADHVTNLERVGEGLGVFMFDKSLKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HKQ7</accession>
    <name>A0A8J2HKQ7_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 13">Protein disulfide-isomerase</fullName>
            <ecNumber evidence="4 13">5.3.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">HICCMSTLAB_LOCUS10112</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Catalyzes the rearrangement of -S-S- bonds in proteins.</text>
            <dbReference type="EC" id="5.3.4.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum lumen</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the protein disulfide isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.3.4.1" evidence="4 13"/>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5101039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HKQ7"/>
    <dbReference type="OrthoDB" id="427280at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003756">
        <property type="term" value="F:protein disulfide isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034976">
        <property type="term" value="P:response to endoplasmic reticulum stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02961">
        <property type="entry name" value="PDI_a_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02995">
        <property type="entry name" value="PDI_a_PDI_a'_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03073">
        <property type="entry name" value="PDI_b'_ERp72_ERp57"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000045">
        <property type="entry name" value="Disulfide-isomerase A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000077">
        <property type="entry name" value="Protein disulfide-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000303">
        <property type="entry name" value="Protein disulfide-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000017">
        <property type="entry name" value="Protein disulfide-isomerase A4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005788">
        <property type="entry name" value="PDI_thioredoxin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005792">
        <property type="entry name" value="Prot_disulphide_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01130">
        <property type="entry name" value="ER_PDI_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01126">
        <property type="entry name" value="pdi_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18929">
        <property type="entry name" value="PROTEIN DISULFIDE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18929:SF132">
        <property type="entry name" value="PROTEIN DISULFIDE-ISOMERASE A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13848">
        <property type="entry name" value="Thioredoxin_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00421">
        <property type="entry name" value="THIOREDOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 13" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10 11" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 13" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035341681" description="Protein disulfide-isomerase" evidence="13">
        <location>
            <begin position="18"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="14">
        <location>
            <begin position="11"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="14">
        <location>
            <begin position="343"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="11">
        <location>
            <begin position="49"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="11">
        <location>
            <begin position="393"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR605792-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU361130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CAG5101039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="491" mass="55564" checksum="3AB066FF66248A78" modified="2022-05-25" version="1">MLSKWFVLCFLALGALAAEEDVLDLTDGDFTAELDRHDNTLVMFYAPWCGHCKRLKPEYAEAAGMLKGSDPAITLAKVDCTEGGKETCSKYGVSGYPTLKIFSKSEMVSEYNGPREAKGIVKYMKGQVGPASKELKGEECQKAFLDTDEVSFIGYFEDEKSELAKSFQSVAKKLREKARFAHSYAKSLLKKEGLKNHIKLYRPKVLQNKFEESVVEHDGGDSIADVNDFVTKNYFGLVGVRTRDNAASFENPLVVAFYSVDYVKNPKGTNYWRNRIMKVAKEFPEFNFAISNKDDFQHELNDFGVEFTKSEKPVVFARDDKGLKYVLKDEFSVENFQKFVKDFEEKNLEPFIKSEPVPEDNSGPVKVVVAKNFEEVVTKPDADVLIEFYAPWCGHCQKLTPIYDELGEKLAKENVVIAKMDATANDVPPEFEVRGFPTLYWVPKKSKSSPVKYEGGRELNDFIKYIAEHSTDKLKGYDRKGNPVKTPSDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HL00</accession>
    <name>A0A8J2HL00_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Olfactory receptor 214</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HICCMSTLAB_LOCUS11022</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5102452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HL00"/>
    <dbReference type="OrthoDB" id="6597368at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005549">
        <property type="term" value="F:odorant binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004984">
        <property type="term" value="F:olfactory receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004117">
        <property type="entry name" value="7tm6_olfct_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21137">
        <property type="entry name" value="ODORANT RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21137:SF35">
        <property type="entry name" value="ODORANT RECEPTOR 19A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02949">
        <property type="entry name" value="7tm_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0552">Olfaction</keyword>
    <keyword evidence="8 11" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="9" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="32"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="66"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="121"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="190"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="261"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="294"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAG5102452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="388" mass="44320" checksum="E655624276AB03E9" modified="2022-05-25" version="1" fragment="single">MDILPECFFIFTCIGLWKPASWTGGKSTAYNFYTLLMTLIPSLFVISGFFDLILLTSDISEIIDNVFLVLTIMAGCGKMISVVANRDKISKIFNSLQTKPLKPQDDEEIIINDQYYKITRFITFCYSTMTGVGVTLFVLGKMLENGPKKMLPYRGWFPYNYSHPLLYSLSAGQQALTMIIAGAVNAAYDTFFPGVMFLVCAQVNIFKHRFKVMLDSLEMENYYEKINKNHEVDHRKVNCVFSECVRHHISIFELFDDISKVFSTVIFVQYSVGSVIFCTSIYRMSDMDVMTIEFVSNIFYIGSMLSQIFLLCVSANQVTLEFQDLNTALYDSKWFAVDNNARKSLIIMMINSQNQVTFTTGHIVTLSLDSFTNLVKLSYTIYNVLQQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HL61</accession>
    <name>A0A8J2HL61_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Similar to Ipo9: Importin-9 (Mus musculus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HICCMSTLAB_LOCUS9906</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the importin beta family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5100833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HL61"/>
    <dbReference type="OrthoDB" id="431626at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001494">
        <property type="entry name" value="Importin-beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058669">
        <property type="entry name" value="TPR_IPO7/11-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10997">
        <property type="entry name" value="IMPORTIN-7, 8, 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10997:SF9">
        <property type="entry name" value="IMPORTIN-9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03810">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25758">
        <property type="entry name" value="TPR_IPO11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00913">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50166">
        <property type="entry name" value="IMPORTIN_B_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Importin N-terminal" evidence="6">
        <location>
            <begin position="36"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="994"/>
            <end position="1029"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="994"/>
            <end position="1012"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAG5100833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="1090" mass="122190" checksum="A5B50A3528D7F085" modified="2022-05-25" version="1">MAMNMNTRDVQNSLKEALYETLNGILSPHRDTRHAAEQRIQALEVTDEFGIHLTEFVVDVNGPLAIRQLSSVLLKQYVETHWCSVAEKFRSPEIKPTTKEKIKELLPLGLHESISKVRVSVAYAIAAIAHWDWPENWPGLFDILVNCLNGAQSEYAVHGAMRVLSEFTRDLSDDNLPSVGPIILQEMYRIFITESYSIRTRGRAVEIFTTIASLVGSTGIYHKAFVETCLKPVIPVFCEKFVVCLREHSSDGSHTTPTCDIGLKTDIIKAINCLVTKLPKFVTAYLPQILPPVWETLTESAKIYQQESVASETLSRRITRVPLSHDDSGDGDDDHDVKENVVVDSDGEIINFNNLIIATFDFIHNLVDHKNFANLIINSVQEAMYYLIIFMQITHEQVELWTANPSQFVEEDEQTVFSYNVRISAQDLLTSLIGYSEDTSINALCEVITRHIEAVNIMQVCNRNIQQNNGIHNNSSIQSLSSPWSSSPSWKICESAILALSIAKEQVIEHIQEGTLRFDLVAFLNTIILDGILNDPTAHPYLIGRCLCLGGRYANQIPPEISARFLEAAVVGLPANQPLCIRMSSIKAVYWFCEAAVNTNTLMTRDIIRPHLSVIFEELFGFVNQASTEILTLIMETFSILIAVDKDFTASVESKICPLTIAVFLKFQSDPEILSLCQDIFKELTENPRCIAPLQNRLVPTLVSMLTVNPVGKNIDEGTRGEALDVLQVLVKSSPQPLNNSLVETAFPAACHCILNSDDNGILQSGGELIRTYLLVGARQIIDHRDSEGRTGLQYVLQIVAQLLNPQSSEFTATFVGRLVITLIKKVGNNLGENLDLLLKAVLSKMQRAETLTVMQSLIMVYAHLLNAEFDAVLNFLSTVPGPTGESALAFVLTEWVQRQQLFFGTYVRKVTIVALSKILEHGVTRPDDFRLNEITVRGDQVFTANDDNIRTTRSKTQSQPFQWTMIPILVKVFKLIINELSYNIEADYAGIGEEDDEDVTQDIEDSDEEEDRRDGTTDGENCWVDPGGAPHLMNIMDDDKTLEEETDSDLLEDSIYHLNLNNYLRDFLTNFSQHHCFPSLFAFANVQLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HLJ1</accession>
    <name>A0A8J2HLJ1_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to RLBP1: Retinaldehyde-binding protein 1 (Gallus gallus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS8184</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5096387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HLJ1"/>
    <dbReference type="OrthoDB" id="440711at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902936">
        <property type="term" value="F:phosphatidylinositol bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1200">
        <property type="entry name" value="Alpha-tocopherol transfer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.20">
        <property type="entry name" value="N-terminal domain of phosphatidylinositol transfer protein sec14p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011074">
        <property type="entry name" value="CRAL/TRIO_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036273">
        <property type="entry name" value="CRAL/TRIO_N_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10174">
        <property type="entry name" value="ALPHA-TOCOPHEROL TRANSFER PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10174:SF234">
        <property type="entry name" value="SD01558P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00650">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03765">
        <property type="entry name" value="CRAL_TRIO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00180">
        <property type="entry name" value="CRETINALDHBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM01100">
        <property type="entry name" value="CRAL_TRIO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00516">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46938">
        <property type="entry name" value="CRAL/TRIO N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRAL-TRIO" evidence="2">
        <location>
            <begin position="212"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5096387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="387" mass="45010" checksum="7662D6233D13FC73" modified="2022-05-25" version="1">MINDENFVNNHKIGTPKKTDMEDKSTKFSNGIKSLDASLIGDKISKESSGNIHKMWEPMLCVQNEIATKSIKENLDIIENNLDEVKQLSKEEMKPKDEELDLDLEEISPEVMEYAKRELGETDEVKCQTLQELRDMIYERGECTPHRMDDAFLIRFLRARNFNVNRAHRLVVRYVNFKEDHPEIHKDVNPLNMRHIGDDDVMTVPAYRTQCGRRMMIYRMGNWDPKKYGIEEIFKATVIILELGVLEPRAQVLGGVVIFDLQDITIAHAWTITPQIASMVMALMVSSFPMKTYAIHILHQSWVFDMIYAMFKPLINKDMKERVFFHGDNMESLHKHIAPSHLPKKYGGTREELPYYKWIDSLSLKPKIVKEMHSLGYIVPEELIKGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HLP2</accession>
    <name>A0A8J2HLP2_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Malate dehydrogenase</fullName>
            <ecNumber evidence="11">1.1.1.37</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">HICCMSTLAB_LOCUS10820</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6 11">
            <text>(S)-malate + NAD(+) = oxaloacetate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21432"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.37"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the LDH/MDH superfamily. MDH type 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.37" evidence="11"/>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5102048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HLP2"/>
    <dbReference type="OrthoDB" id="755699at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030060">
        <property type="term" value="F:L-malate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006108">
        <property type="term" value="P:malate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01337">
        <property type="entry name" value="MDH_glyoxysomal_mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.110.10:FF:000001">
        <property type="entry name" value="Malate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.110.10">
        <property type="entry name" value="Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001557">
        <property type="entry name" value="L-lactate/malate_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022383">
        <property type="entry name" value="Lactate/malate_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001236">
        <property type="entry name" value="Lactate/malate_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015955">
        <property type="entry name" value="Lactate_DH/Glyco_Ohase_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001252">
        <property type="entry name" value="Malate_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010097">
        <property type="entry name" value="Malate_DH_type1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01772">
        <property type="entry name" value="MDH_euk_gproteo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11540">
        <property type="entry name" value="MALATE AND LACTATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11540:SF16">
        <property type="entry name" value="MALATE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02866">
        <property type="entry name" value="Ldh_1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00056">
        <property type="entry name" value="Ldh_1_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000102">
        <property type="entry name" value="Lac_mal_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56327">
        <property type="entry name" value="LDH C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00068">
        <property type="entry name" value="MDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9 11" id="KW-0520">NAD</keyword>
    <keyword evidence="4 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Lactate/malate dehydrogenase N-terminal" evidence="12">
        <location>
            <begin position="27"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="Lactate/malate dehydrogenase N-terminal" evidence="12">
        <location>
            <begin position="76"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="Lactate/malate dehydrogenase C-terminal" evidence="13">
        <location>
            <begin position="153"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="183"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="32"/>
            <end position="38"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="123"/>
            <end position="125"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="125"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="159"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="234"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000102-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000102-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000102-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CAG5102048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="320" mass="33720" checksum="288014F4954F8583" modified="2022-05-25" version="1">MLPRLLKPSVIAQGAKQLSTSSQRNAKVAVMGASGGIGQPLSLLLKQSPLVTELSLYDIVNTPGVAADLSHIDTHSKVVIIPAGVPRKPGMTRDDLFNTNASIVRDLAKAVAEVAPKAFIAIISNPVNSTVPIASEVMQKAGVYDPNRIFGVTTLDIVRSNAFIGEAKGLDPQKVSVPVIGGHSGITIIPVISQAKPSVSFPDDKLKALTERIQEAGTEVVKAKAGTGSATLSMAYAGARFGFSLIRALNGEQNVVECAYVRSNVTEAKYFSTPVLLGKNGVEKNLGLGKLSAFEEKLLAAAIPELKKNIQKGEDFVNKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HLY4</accession>
    <name>A0A8J2HLY4_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Similar to br: Broad-complex core protein isoform 6 (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HICCMSTLAB_LOCUS8520</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5097057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HLY4"/>
    <dbReference type="OrthoDB" id="10261408at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048513">
        <property type="term" value="P:animal organ development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003006">
        <property type="term" value="P:developmental process involved in reproduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048666">
        <property type="term" value="P:neuron development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18315">
        <property type="entry name" value="BTB_POZ_BAB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051095">
        <property type="entry name" value="Dros_DevTransReg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003656">
        <property type="entry name" value="Znf_BED"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23110">
        <property type="entry name" value="BTB DOMAIN TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23110:SF106">
        <property type="entry name" value="FI01104P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50808">
        <property type="entry name" value="ZF_BED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="BTB" evidence="8">
        <location>
            <begin position="43"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="365"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="414"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="domain" description="BED-type" evidence="10">
        <location>
            <begin position="424"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="440"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="127"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="314"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="136"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="160"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="196"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="207"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAG5097057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="526" mass="58241" checksum="840E40DA288281C1" modified="2022-05-25" version="1">MIEDIIISGTVMGSSQQFSLRWNNYLKHITCAFDTLRTDEDLVDVTLSCEGKRIRAHKMLLSACSTYFRDLFKENPCQHPVIIFRNVKFDDLAALVDFMYQGEVNVVQEQLASFLTTAELLAVQGLTDGTGKDNDSVTEEDVELPNEPEVQLQNPAGKHMTNNKGGKSPSSPMQFHSIELQPEIPPAKRRKYRDSGLSNADKSSIGSKKDLNDKLNENQVNTPGSNPVEIIPLMPNLKLEMPEYLEQDASSCSYEEQNTGDGSAIKLGDDVLSNAVDEEHKPDISQTFYSSQSSDIPDAKHATATAAADIGHLLSKPSTSSERIPQEAAQDPRRNNGSGKIGPDAPELHSSPNDNLDEPSKTGIFRCRICPKTFKHPISLALHKNVHAGQTKCPFCQHVFSRNSRTVVIEQPSHSCKLCGKSFWNRDSMYKHMNMHKGTTQCPVCHKVLSRTTHMKRHLKNRHGWLGFGTVTDTTTVRNATQLPTVTSAAIAQQNANTANTETNATFTTIRIRESSVERITSSPIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HM46</accession>
    <name>A0A8J2HM46_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Similar to GA20843: LMBR1 domain-containing protein 2 homolog (Drosophila pseudoobscura pseudoobscura)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HICCMSTLAB_LOCUS11674</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the LIMR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5103767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HM46"/>
    <dbReference type="OrthoDB" id="203099at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051584">
        <property type="entry name" value="GPCR-associated_LMBR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006876">
        <property type="entry name" value="LMBR1-like_membr_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21355">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR-ASSOCIATED PROTEIN LMBRD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21355:SF0">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR-ASSOCIATED PROTEIN LMBRD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04791">
        <property type="entry name" value="LMBR1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="32"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="107"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="147"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="185"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="439"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="507"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="512"/>
            <end position="528"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG5103767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="620" mass="71366" checksum="42E8F6EE2289DC39" modified="2022-05-25" version="1">MSVGPLVTEIVLAFCLATTLLYRYGNIFRNHIVVTVSVLIAWYFSLLIIFVLPLDVSSTVYRQCVEKNSRYNLSITTDNNNTSNVTIKCEKPWSSVPDSVFPNLWRIVYWTSQCLTWLILPLMQSYIKAGDFTVKGKLKSALIDNAIYYGSYLFICGVLLIYIALKPGLDLDGQKLKAIASSASNTWGLFLLIMLLGYALVEVPRGLWNASKPGFTLQYSYFKASKLNLEKCEAEETVDDILESLQAASTAIGSTHPFHRNLETIFQKVPIELKERMNRRQLPEDAHTNAPSEKSLIRLHRQTIKALQTLQRTETQWGILVEQIFHLEDISKNQTNHDRRFKSSFPTIRPFFIRLIYNPTLVLKIRLLNLYYLAPHHQTNEYSLIFSGMMFCRLTPPMCLNFLGLIHMDSHIIKTHILETHYTQVMGHMDVISIISDGFNVYFPMAILAFCLATYFSLGSRLLSVLGFQQFLGDDEVTTDLVDEGRELIQRERRRRQRIEESIMRRREFQERTNNPARNRNSRQSVDTVRSVKRDESTESVRAGLLRDFDTSDYYVGTTFNSSSNRYGANNAYERNGYQSSDFYDINNDEDNSRIYSSSSINNSSSNYSRAPPRRIFDDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HMJ1</accession>
    <name>A0A8J2HMJ1_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Inositol 1,4,5-trisphosphate receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">HICCMSTLAB_LOCUS10400</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="16">Receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium.</text>
    </comment>
    <comment type="subunit">
        <text evidence="16">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 16">Endoplasmic reticulum membrane</location>
            <topology evidence="1 16">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="16">The receptor contains a calcium channel in its C-terminal extremity. Its large N-terminal cytoplasmic region has the ligand-binding site in the N-terminus and modulatory sites in the middle portion immediately upstream of the channel region.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 16">Belongs to the InsP3 receptor family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5101327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="76898at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016529">
        <property type="term" value="C:sarcoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030667">
        <property type="term" value="C:secretory granule membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070679">
        <property type="term" value="F:inositol 1,4,5 trisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005220">
        <property type="term" value="F:inositol 1,4,5-trisphosphate-gated calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051209">
        <property type="term" value="P:release of sequestered calcium ion into cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd23277">
        <property type="entry name" value="beta-trefoil_MIR_ITPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.80.10.50:FF:000002">
        <property type="entry name" value="Inositol 1,4,5-trisphosphate receptor type 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.80.10.50:FF:000005">
        <property type="entry name" value="Inositol 1,4,5-trisphosphate receptor type 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.30:FF:000001">
        <property type="entry name" value="Inositol 1,4,5-trisphosphate receptor, type 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.30">
        <property type="entry name" value="IP3 receptor type 1 binding core, RIH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014821">
        <property type="entry name" value="Ins145_P3_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000493">
        <property type="entry name" value="InsP3_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036300">
        <property type="entry name" value="MIR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016093">
        <property type="entry name" value="MIR_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000699">
        <property type="entry name" value="RIH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015925">
        <property type="entry name" value="Ryanodine_IP3_receptor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035910">
        <property type="entry name" value="RyR/IP3R_RIH_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13715:SF102">
        <property type="entry name" value="INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13715">
        <property type="entry name" value="RYANODINE RECEPTOR AND IP3 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08709">
        <property type="entry name" value="Ins145_P3_rec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02815">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01365">
        <property type="entry name" value="RYDR_ITPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00779">
        <property type="entry name" value="INSP3RECEPTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00472">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100909">
        <property type="entry name" value="IP3 receptor type 1 binding core, domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82109">
        <property type="entry name" value="MIR domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50919">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 16" id="KW-0106">Calcium</keyword>
    <keyword evidence="5 16" id="KW-0107">Calcium channel</keyword>
    <keyword evidence="4 16" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="8 16" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="15 16" id="KW-0407">Ion channel</keyword>
    <keyword evidence="11 16" id="KW-0406">Ion transport</keyword>
    <keyword evidence="14 16" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="12 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="13 16" id="KW-0675">Receptor</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 16" id="KW-0813">Transport</keyword>
    <feature type="domain" description="MIR" evidence="18">
        <location>
            <begin position="114"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="MIR" evidence="18">
        <location>
            <begin position="235"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="MIR" evidence="18">
        <location>
            <begin position="298"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1145"/>
            <end position="1170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU368044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="CAG5101327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="1615" mass="183950" checksum="65C5337A2F37D0ED" modified="2022-05-25" version="1">MGEILGSASFLHLGDIVSLYAEGTVSGFLSTLGLVDDRCVVCPEAGDLVNPPKKFRDCLFKICPMNRYSAQKQFWKAAKQSGSSTTDAVLLKRLHHAAEIEKKQNDTENKKLLGSVVSYGNVVQLLHLKSNKYLTVNKRLPALLEKNAMRVYLDANGNEGSWFYIMPFYKLRSDGDSVVVGDKVIMEPVNSGRQGLHVAANYELSDNPGCKEVNVVNASTSWKVTLFMEHKENQEEILKGGDVVRLFHAEQEKFLTMDEYKKKHHVFLRTTGRTSATAATSSKALWEVEVVQHDPCRGGAGHWNSLFRFKHLATGQYLAAEIDIDEPLDTSKLKRDLSGAAYRLVSVPHSNEISSLFELDPTTLTRADSLVPQSSFVRLHHICTNTWVHSTSVPIDKDDEKPVMSKVGCAINKEDKEAFALRSVSPVEVRDLDFANDACKVLASISGKLEQGTISHNERRAVTSLLQDIVYFIAGLENEQNKSEALDLIVTNAVRDRQKLLREQYILGQLFKILQAPFLESNEGEGPFLRIEELNDPRHAPYKYIFRLCYRILRLSQQDYRKNQEYIAKFFAFMQKQIGYDILAEDTITALLHNNRKLLEKHITAAEIETFVGLVRKNMKNWESRFLDYLSDLCISNKKAIAVTQELICKSVLSDKNKDILIDTKMIKTQLEVEENINEEHEHEHEHHDDTSEITQITILEEFEIVLTWNNGKRSMSLSELSRGAKIGNHEHIAILDYYRHQLNLFSNMCLNRQYLALNNLSPHLDIDLILKCMEDETVPYELRASFCRLMLHLHVDRDPQEPVTPVKYARLWSEISSKISINDYDTNKMPDENKEAVRARFSSTILFVEDYLCNVVSNVWSFADHEQNKLTFEVVKLARDLIYFGFYSFSDLLRLTKTLLNILDCVSDKDFIDGKISSTSESDTESLDSKNEAEGGVLKCIGDMGAVMTSLALGPAGQTMSGSSSPRSSPAAKKEYPLVMDTKLKIIEILQFILDVRLDYRISCLLSIFKKEFDENERMSGDGSLEQKGIDLEAIGTQAEGIFGSSDECLALDLDGQGGRTFLRVLLHLAMHDYPPLVSGSLHLLFRHFSQRQEVLQAFKQVQLLVSDSDVESYKQIKADLDVLRQSVEKSELWVYKSKSVEEHGGKKKKSNKEDEDEGATPRKMPPKLAQIDKRGSAIDLDVGPPLHADQAEEYRKIQQILIRMNKLCIQTLPGGIVKPRKHEQRLLRNVGVHTIVLDLLQVPFDCKEDTRMNELMRLAHEFLQNFCLGNQQNQVLLHKHLDLFLNPGIREAQTVCSIFQDNSTLCNEVSPKVIQHFVHCIETHGRHVQYLKFLQTIVKAENQFIRKCQEMVMQELVQAGEDVLVFYNDRASFNYFIEMMKSERYRMDESSPLKYHVELVKLLACCTMGKNVNTEIKCHSLLPLDDIVAMVSHPDCLPEVKEAYINFLNHCYIDTEVEMKEIYTSNHMWSLFERSFTVDMAIIGTATHDRNHADTALENYVLNCLMNIITTFFSSPFSDQSTTVQTRQPIFVQLLHAAFKVSQCAWLNAGQRFNVENCIRTLSEVECPSSEDGMERFACPTPDRMGRYRCIDDHTKAHLDVLAEALLRWVRGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HMK7</accession>
    <name>A0A8J2HMK7_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Farnesyl pyrophosphate synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HICCMSTLAB_LOCUS10417</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5">Pheromone biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the FPP/GGPP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5101344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HMK7"/>
    <dbReference type="OrthoDB" id="10257492at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004337">
        <property type="term" value="F:(2E,6E)-farnesyl diphosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004161">
        <property type="term" value="F:dimethylallyltranstransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045337">
        <property type="term" value="P:farnesyl diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042811">
        <property type="term" value="P:pheromone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00685">
        <property type="entry name" value="Trans_IPPS_HT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039702">
        <property type="entry name" value="FPS1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000092">
        <property type="entry name" value="Polyprenyl_synt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033749">
        <property type="entry name" value="Polyprenyl_synt_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11525:SF0">
        <property type="entry name" value="FARNESYL PYROPHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11525">
        <property type="entry name" value="FARNESYL-PYROPHOSPHATE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00348">
        <property type="entry name" value="polyprenyl_synt"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00723">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00444">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00033740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00034546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG5101344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="369" mass="42816" checksum="4E1B4A2DA2411B1E" modified="2022-05-25" version="1">MSVVINRATSKLFQRGIYQNLIDTSIKKNHSVISHIKLNSTNQFVRSPLCRMAHSMVQTNWTSSKDESREMMALWPDIVRVLTEAGRHLEIPDATKWMTKVLQYNVPNGKKNRGLALVYAYRMLAPRDQLTEENIRLARTLGWCTELLQAFLLIEDDIMDHSVTRRGQPCWYLNNNIGLSAINDGILLEQTVYQLLRTPNFNLFTMNRYNAIVKYKTAYYSFVMPITLAMHFAGVVDPEMYRQAKTILLEMGHFFQVQDDYLNIYGDPRITGKQGLDIKEGKCTWLAVVALQRVTPSQRKIFEECYGVDDEEKVAQIKQLYDDLGLSTTYAIYEEESYNLMNTHIQQISRGLPHDLFFKILSKIYRRDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HMM6</accession>
    <name>A0A8J2HMM6_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Mitochondrial inner membrane protein Mpv17</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HICCMSTLAB_LOCUS11111</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the peroxisomal membrane protein PXMP2/4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5102631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HMM6"/>
    <dbReference type="OrthoDB" id="430207at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007248">
        <property type="entry name" value="Mpv17_PMP22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11266">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN 2, PXMP2 MPV17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11266:SF17">
        <property type="entry name" value="PROTEIN MPV17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04117">
        <property type="entry name" value="Mpv17_PMP22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="55"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG5102631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="87" mass="10118" checksum="3BEDB300AA4CCB31" modified="2022-05-25" version="1">MSRFLKFYKQLLVKYPLGLQALQAGALMAVGDQMAQNLLWPMVQLVNFTFVPLHYQVLFVQSVAVFWNTYVSFRTNRDTLNKKNNTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HN49</accession>
    <name>A0A8J2HN49_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS12667</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5107274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HN49"/>
    <dbReference type="OrthoDB" id="10017216at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5107274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="78" mass="9525" checksum="16448C351FE8F517" modified="2022-05-25" version="1">MNLSKFAIASERVPTNELETWDENATGWEEETVEEFGDPTEEIREQRRRERERRLYEQHQRRMDYNFRPPPLGEKINS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HNQ0</accession>
    <name>A0A8J2HNQ0_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Mannosyltransferase</fullName>
            <ecNumber evidence="8">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HICCMSTLAB_LOCUS12912</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Endoplasmic reticulum membrane</location>
            <topology evidence="1 8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the glycosyltransferase 22 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="8"/>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5107775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HNQ0"/>
    <dbReference type="OrthoDB" id="416834at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000026">
        <property type="term" value="F:alpha-1,2-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005599">
        <property type="entry name" value="GPI_mannosylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22760">
        <property type="entry name" value="GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22760:SF4">
        <property type="entry name" value="GPI MANNOSYLTRANSFERASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03901">
        <property type="entry name" value="Glyco_transf_22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="2 8 9" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="16"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="68"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="166"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="206"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="253"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="293"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="322"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="463"/>
            <end position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAG5107775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="481" mass="57017" checksum="7278D6F01FBCCC27" modified="2022-05-25" version="1">MFLHYLRFGRMADRNLLYFLIFIKLIVCWLVKTFYVPDEYWQSLEVAHRQAFGYGYLTWEWNYKIRSYVYPFVISIIYKILAIFRLDSPEMIIFLPRLFQAMLSGFAEYRFSKWTQNDLTTVFLLMNPFWNYCATRTLINTLETSLTMIALSIFPWNEKDKHRSNFIWLVGFMFFIRPTAAIMWAPLCLYHVYIFKKSINQLIKDYFFIGLCVSGIAIAIDSYCYGQLVVTPWEFFKVNVLTNVANHYGKQPLLWYLYSALPVFLLIKPLISLAIIVWTITIYSVLPHKEHRFILPLLPLLVYLITNYNYQTHVSEKLKNIIVFILLFINFGLLCYIGIVHQQGSTKIMHYLRYEIDNSQSDVDVMFLTPCHSTPFYSYVHQNISIEFLTCEPNLQNQDNYLDEADIFFNDPMAWLEKRYTNSTLPLLVVIYDNLAPRIKGFIDNYRLVLSDYTFREKRDKRNVVNAVLLSNIFAVISSTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HNV5</accession>
    <name>A0A8J2HNV5_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to fam120a: Constitutive coactivator of PPAR-gamma-like protein 1 homolog (Xenopus tropicalis)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS11929</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the constitutive coactivator of PPAR-gamma family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5104292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HNV5"/>
    <dbReference type="OrthoDB" id="10061469at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18672">
        <property type="entry name" value="PIN_FAM120B-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1010:FF:000009">
        <property type="entry name" value="Constitutive coactivator of PPAR-gamma-like protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026784">
        <property type="entry name" value="Coact_PPARg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15976:SF16">
        <property type="entry name" value="ASTEROID DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15976">
        <property type="entry name" value="CONSTITUTIVE COACTIVATOR OF PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="331"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="394"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="873"/>
            <end position="928"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="940"/>
            <end position="982"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="348"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="429"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="890"/>
            <end position="906"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="908"/>
            <end position="924"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="971"/>
            <end position="982"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5104292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="982" mass="109675" checksum="6C5EC0C4477E2068" modified="2022-05-25" version="1">MGIQDFQTFLDSNCIPGGAVTVDLLKIARQVIQRQRNRLNKAQSSHPPLLRLVLDAECCLDRLYGGYFSDWACGGQWNRMLQFLAILIQATELSGADLVVFFNGCNEVPRRSEWIQQQLQMRNKVNNVLKHIATKGTPPPKIWWTPPVCLRTSLRMALRHLKVSVMCSMDDHHQEVIAYCRENNFNGLVADDGEYAAFDPPRYFSSEQLKLTYKGSLDTKEYLMSEVNKSLGIPSDRLCILAALLGNYILTEQELTDFYKKLNINITGPNKTNIDQSIKIIATFVKDLPSTDKDVLAQKVFGSTSDPRCSKLHQSVQYYINGTKEGFLHYKTTKPTKGTHKPDKKNPVVNQQNSTEATTPDENCAMGTSRFASETAESERESLDAYNQATANAKAAPQIVIEPPQQSQGDGDVKTDDEQPATEPAVNGTHSNLSTSSPNSNGSSSVTSPSHPTTGQTKVADKPVSIPTTVPEVMRTASERHQKGLMSPHIYQILATGEIKLPVLLEDENQREFPSIHIIYRPVRQMVYAILFNLHHQIFMATKNKEKGDEKIEVPDIVIKEWVWSKTNPYQTPELIKAEQIGWGVPTIQRLWFGTGIEDKRRRLRGFLTCMKSDTSLMLNISYVPQHLLVMACVLRYIMYFSDKTKILRRQELDAFIVQAFSPDLMNPQYLQDLQLPLVTFRGVQLATLFMAGVETALLANDACGAPIPWLMCCPWLFFDGKLFHHTLARAAVAKNLLELCGGHIDRVVKVERMRKAIIEGFNPVYARPPQPPIASNLIPGFRSLGLTPNGLPVSCALNDTQNRARVNRPVNVLQRELIRRPVPSRGGQLEIAGVVVGQWGANYGQPGRIQGPQPIQGHLRGRLPQQVPFPRLNTRMFQPRGGNNSIATRGKKTQMKATSKKKSAVKKNQENDMKKDSKNRDNSVDEVNADAFSKLLVKDVNAKEKTESNQQTESAVNGGGKPVEKGQGDASLNVSQTVKDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HP64</accession>
    <name>A0A8J2HP64_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS11415</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5103249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HP64"/>
    <dbReference type="OrthoDB" id="1925699at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006616">
        <property type="entry name" value="DM9_repeat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31649">
        <property type="entry name" value="AGAP009604-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31649:SF1">
        <property type="entry name" value="FARNESOIC ACID O-METHYL TRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11901">
        <property type="entry name" value="DM9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00696">
        <property type="entry name" value="DM9"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5103249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="151" mass="16899" checksum="ED4D7626937503E4" modified="2022-05-25" version="1">MNTYHSLTRYKWVRYSGARYWTPGMITIGRDLDGAHLVVGRAHHHGDLLPAKAKPEHGVAYVTHGGAEHMKHDFEILMPAEFHWIPSRHGQIPPGAVEGGRTSNGEVLFVGRAHHNGTPCVGKIHPSHGSLYIPYNGEEIPYKEYEVLVQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HPB2</accession>
    <name>A0A8J2HPB2_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Odorant receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HICCMSTLAB_LOCUS12246</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Cell membrane</location>
            <topology evidence="1 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the insect chemoreceptor superfamily. Heteromeric odorant receptor channel (TC 1.A.69) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5106410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HPB2"/>
    <dbReference type="OrthoDB" id="7664278at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005549">
        <property type="term" value="F:odorant binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004984">
        <property type="term" value="F:olfactory receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004117">
        <property type="entry name" value="7tm6_olfct_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21137">
        <property type="entry name" value="ODORANT RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21137:SF35">
        <property type="entry name" value="ODORANT RECEPTOR 19A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02949">
        <property type="entry name" value="7tm_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 10" id="KW-0552">Olfaction</keyword>
    <keyword evidence="8 10 11" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="9 10" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="31"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="61"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="110"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="168"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="258"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU351113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAG5106410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="390" mass="45303" checksum="88062015F16F2B7A" modified="2022-05-25" version="1">MDIYEEPYYIITKGFASFIGQWPYQSRKQSIMFGSIMWSLFILQVIPQVVSVALHYDDEELLFESLSPFITDLIFIVKYVNMKTLFDKMKDDWKILKNDKEKSILENHMFTARYISLCWAAFVNVTVFIFLMDPILPIIVNHIQKSNESLPVRFCVPMEYVIINEEKYYWLLFSFSSICVIFIIMVIICCDIIFISLVQHVCGIFAVVGFRIENSPTVDLSSEMLTGLRFKTNSRDVHYKHFVSCIRDHRRALEFADLIEATFTGCFGIVVGLNLPLMSITAVQIMTQSQSIQDTVKYIMFTFAQMIHLFFDCYMSQRLTDMSDHIHQCIARAKWYENSARSRKLLILMTLRSQIPCKLTAGKVMELSIETFGMCLKTAGSYVTVLLSMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HPH0</accession>
    <name>A0A8J2HPH0_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Similar to akap-1: KH domain-containing protein akap-1 (Caenorhabditis elegans)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HICCMSTLAB_LOCUS13475</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5108839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HPH0"/>
    <dbReference type="OrthoDB" id="10069557at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd22395">
        <property type="entry name" value="KH-I_AKAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047368">
        <property type="entry name" value="KH-I_AKAP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035437">
        <property type="entry name" value="SNase_OB-fold_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002999">
        <property type="entry name" value="Tudor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050621">
        <property type="entry name" value="Tudor_domain_containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22948:SF65">
        <property type="entry name" value="A-KINASE ANCHORING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22948">
        <property type="entry name" value="TUDOR DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00013">
        <property type="entry name" value="KH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00567">
        <property type="entry name" value="TUDOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63748">
        <property type="entry name" value="Tudor/PWWP/MBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50084">
        <property type="entry name" value="KH_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="K Homology" evidence="3">
        <location>
            <begin position="324"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="36"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="169"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="279"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="173"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG5108839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="630" mass="70520" checksum="2F280B2B181AAFA8" modified="2022-05-25" version="1">MSVKNIQLMKWSFPAFAFIIGFFWYKRRALDRVDPGGIPRSDKSSPAKEPATDKSNGEINTSKKNDLDLYDSGIHVEKSLNSLSLLDQTPPKEQVVTFSPRKVSESLDIPMKKSDSMSIRSRKSSGNSIPWYEDVEGLPDMKEVVLGSNPKSSSFDRMIRKKPPVILENIEDNNNTNNNNNNNNNNTGEEQVSGREVVVSKVEASIEQGQVVIKEQNEVQEPVKEEGDKAAPEEQDELLQQTVVASPQTRSRSISIETCEKTNDTASAGDETKTGQALFERDSANHSPVSGVLDGSVNDDIRSEGSTDSGKGGSINGKVPKNNSKTFYEFLIPEKFVGKLIGKHGASIKSLNDQANVNITIDFHPLDEDLRLCIIEGLSENIATALDLIRQKFPKKAYPGFTLEQVNVTTSPEEITWVPELMQLQLVESLNNDVLVCHILKPNRLFIQLPTHPTYPSFKLLDYNLTQFYSTVESPHVPDQLTRGMIVVAQWYNKWVRAYVEQPDIEGLQHLLRLVDHGGFWKFSSAELRQIRSEFLTLPFQTLEVNLAYVRPINGEWTQEAFDVVSQICSNRISQAQVEAYTNTEIFVSLYIELPKHGVISLADELVARGYAESVSFEELLADHCTPLVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HPW3</accession>
    <name>A0A8J2HPW3_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SANTA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS13363</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5108690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HPW3"/>
    <dbReference type="OrthoDB" id="118550at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015216">
        <property type="entry name" value="SANTA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09133">
        <property type="entry name" value="SANTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SANTA" evidence="2">
        <location>
            <begin position="180"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="331"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="556"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="756"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="869"/>
            <end position="905"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1083"/>
            <end position="1261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="343"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="869"/>
            <end position="879"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="891"/>
            <end position="905"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1097"/>
            <end position="1110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1119"/>
            <end position="1144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1145"/>
            <end position="1165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1171"/>
            <end position="1182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1209"/>
            <end position="1222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1252"/>
            <end position="1261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5108690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="1261" mass="143291" checksum="9D766A332A77F5D4" modified="2022-05-25" version="1">MTSPPNITFGYLQMEERYKNLERSIKKMQLNQRINETGTNQVLDSRSCASSVNGNMLDCETSSRVGSEVVSSSTNMRNILSQRLNTPTHGITTSSVKNSPEVIDRAIMPPPKTIGILAHSSRRNSLASPQIVPKTTTSGIESNTSVISAINYPSASEFDKQKSNILHSTLDTSKPDRIFQRWKVALSNTGELLIKGFIEGNKYVRSKPVVERINSTTVKSFFSHIYSLEGRIHDEAKELPEYVRGKFYNGFPDDWKNVHHVWQSFVAGGCSDNFRWPTPITDSDDDLISEITEVNNSKSLKRSRARKRLLRNHESTGDFLKKSLIESSVKQKLSSPRHPSVKSAAQISGDPQSSIFQTPTESLQKDLNKSPRSRSRVNQEVAADSDNESRQAVDKVLGTILLNSANVQPSDEQLETLKAFSILLKNKKYSVEFLENIVEMSNSLMSVISRTSDEHPAESNQFSMIESNISSKNHSATYTKAGINKNLSAKSNKMLREQVVDQVSSKHSAKNNSKYVPVRRKLTNRHYDTSDEFDSHDDDEPYDSRYALKSRLVRIPSKRLPERPGRVNHARRRRSLDSESSDLDEFAHKNKKSLVSPAYDDRRKNTNVVEPEQKKFLRNEIRKPIQSQHTVRNSRIPLPRSVYLHDRGGAESASTITGFLANYDSCASITEDERALRTMGRQNIHLEQNKKMTVPVGPKYPLCYDSCISITEDESSRLKKVIKENNYKKPILQEKNAQYLDQVMKRTSIQRLNQLAGHGKPQQRPATHSETTEEFPQAVSSKATMTDDKENEKIANNQALHPVSPKIIQIEERQDTVKKITPEKIKPTIVRIENVAMKLNSRQMESLSRKVKSPKKIIDNQLTEDKLIKKSRSTEDKPKVLKSPEILEPNVPDKSKSTEKYPRDTRNDKLLEMQSQIVFGSEKNPKVLTCWMPNIKKLSEKKYGLVFEGKLLNEAGHVSTKKYVTDMIIRRVTPKLVETVNNEFYELSGDIVNNKHLVPQELQKLCLDGCPAKITAFCEKWANIKYDNSNAATQSLNGSVDIASAPTSSRGRRIVQSLRYWEGERLSMKGDEVYYSPGHFQESITSSNEASKKDTLHSSPRKQQSTSKNELTVVKKNQSHLEKEKKSKPPVEQDDLVNAKKLKDNNNYNLNNKKSSAKKTASPRVSESRRRSQRFRSLKRKSYREVKSSSDSSDSDDGKLQSKRRRNVNRNELRPEDNDRKIGSKNKSKHDRGSSDSDKTPQGTSYQYRKVAYRDKFFSDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HQD4</accession>
    <name>A0A8J2HQD4_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS13819</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5109183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HQD4"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5109183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="121" mass="13628" checksum="E3C84B4F04EAFA0F" modified="2022-05-25" version="1" fragment="single">FGDNNSSLNPYQITEQRILIRYTWLSGAVKLHTFQLFFWQSSVAKGIWILSNSTISFHSATSLIIGGKSATFSSIVAIANFVKVLGEFISAEMQKFNPGEDFISNKFELSCFFSELICIFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HQG8</accession>
    <name>A0A8J2HQG8_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Mitochondrial (Rattus norvegicus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS12366</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5106651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HQG8"/>
    <dbReference type="OrthoDB" id="294295at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008202">
        <property type="term" value="P:steroid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43313:SF36">
        <property type="entry name" value="D-BETA-HYDROXYBUTYRATE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43313">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE/REDUCTASE FAMILY 9C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="14"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="37"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5106651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="359" mass="41277" checksum="2A3E70BC20FDE3D6" modified="2022-05-25" version="1">MELLKSISNSSRQPYFDIIFFIITLSCLYIFKCINVYTLSTLFTINTIWLFYFKNKRKSIAPGDMVVITGCDSGLGFSLAFHCHKNLNAHVIAGVHNIDSPGANELSKAGILVHSLELTSSESVQAFVQYIRNDLKNKNLALRCFINNAGIMIFGEFEWQTEKQVRYQVEVNLLGTMRVTKEILPLLREYSSRLINVTSHCAYESLPGVAVYSSTKSALASWTNALRVELKKFGIKVVNFIPGSFVLQSNILCQQQKYFKMMEAAMTPEAKSLYSDYFTRYANYLCGLPCNATAVPQILENSNLYDLFEGAMLDQYPRAIYKCEPWRYMIYNFFFKYTSTEIRDWLIEKFVKMPSWKNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HQI9</accession>
    <name>A0A8J2HQI9_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Similar to GPR158: Probable G-protein coupled receptor 158 (Bos taurus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HICCMSTLAB_LOCUS12670</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G-protein coupled receptor 3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5107280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HQI9"/>
    <dbReference type="OrthoDB" id="9970547at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043458">
        <property type="entry name" value="GPR158/179"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054714">
        <property type="entry name" value="GPR158_179_extracellular"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32546">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR 158-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32546:SF25">
        <property type="entry name" value="MIP05539P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22572">
        <property type="entry name" value="GPR158_179_EC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 12" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0807">Transducer</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035204397" evidence="10">
        <location>
            <begin position="22"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="786"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="domain" description="GPR158/179 extracellular" evidence="11">
        <location>
            <begin position="264"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="domain" description="GPR158/179 extracellular" evidence="11">
        <location>
            <begin position="643"/>
            <end position="740"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF22572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAG5107280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="805" mass="93361" checksum="273924922E372FAC" modified="2022-05-25" version="1">MVRLALTVSYVLACFKLGVVGQFEWQPIDHFDEIQARVNLVNKDNCQIKRDNDLYLPPDSVSHLPNIKDININPVFPNRTGLLYIHNLAISRAYFWSYSLQSRFIRPALNDTYDPGMMYYFLSSVADVSSNPHVNASATYFAPNMSFTPSYRGFFNKTLPRFAPRVIRADDFNDPVHMERISTRNTFTADDLGAFAPSSFSLDYTNALYRINKWYSAWLPDVNPQKRHDTKTTYQVEIRYANNTNETYSFHGPPGADENPGPVKWTEPYFDCDRSNRWLVAAVVPIADIYPRHTAFRHIEYPTYTAVSVIEMEYERIDINQCPKSDGNNGPNHFSNTAKCKNETTECEPLHGWGSGRRGAYQCRCRPGYRLPSQVRRPYLGEIIERATDEQYHNGFDCVPIGYRQVLPIEWHKAPKYLRDKYLEKYPEYVNSTVGPESFQTPKINIHNVLTFMRSVNGHNCKLYTKADLTLHGDVGYGSTEFFENQARMATRLANFISAFLQLNNPKEVYSGKRVPDKELTEDQMMGETLALLLGDTKIWAAGTYWDRNKFTNRTFFAPYAHKPQLNTRKYYIEDIARLNATGEVYTNKPWFKFLQQRWATNFDELEKYYLKLHIRFNETGEYHKKFEQYPTSYRAANLNHGHWTTPYFDCNGKVNKWVITYASPFFGWDSLRLKLEFKGVVAVTMNLMDMDINQCDDKFYVPNAFKGTHKCDRKTSYCVPIFGRGFDLGGYKCECKQGFEYPLEDPTTYIDGQIMEAEFQNIIEDKKTRIGLFKCRLAGASAAQASYTLVILMAMFFIFRVAQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HR28</accession>
    <name>A0A8J2HR28_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS13699</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5109063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HR28"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="175"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="176"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5109063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="870" mass="91892" checksum="016E29CFE290DFB5" modified="2022-05-25" version="1">MKITDGKTFVVYVGITIWLHVSFEVEKSNALILRHKIPNQTKWYKTRYCLRNRNCEDDQICGLGICINPCLYKKYCNNEVFQVSNHKTRCQNVLLMTTISTTNNVMSTTTSTESKTTTNGKIDSTPAILSRVGAPVIPTTPKILDLSNEGTRQSTPAILSRVGAPVIPTTPKISLDFSNEGTRQSTPKIPSTVGAPATPRRPEILSEFFPPVAPLVTSTPRFPPVPRLPIIPGLSSPSPVAMPVFSTTRYPSLPGPSTPDHSRPVVAPLVHMRSGFPPVSHPIILGSSTPSPIAIPVSSMLRSPSLRPPSIPGLPSPPPVAMPVFSTTRYPSLPGPSTPDHSRPVAPPLVHMRTGFPLRPPSIPGLPSPPPVAMPVFSTTRYPSLPGPSTPDHSRPVVAPLVHMRSGFPPVSHPIILGSSTPSPIAIPVSSMLRSPSLRPPSIPGLPSPPPVAMPVFSTTRYPSLPGPSTPDHSRPVVAPLVHMRSGFPPVSHPIILGSSTPSPIAIPVSSMLRSPSLRPPSIPGLPSPPPVAMPVFSTTRYPSLPGPSTPDHSRPVVAPLVHMRSGFPPVSHPIILGSSTPSPIAIPVSSMLRSPSLRPPSIPGLPSPPPVAMPVFSTTRYPSLPGPSTPDHSRPVVAPLVHMRSGFPPVSHPIILGSSTPSPIAIPVSSMLRSPSLRPPSIPGLPSPPPVAMPVFSTTRYPSLPGPSTPDHSRPVVAPLVHMRSGFPPVSHPIILGSSTPSPIAIPVSSMLRSPSLRPPSIPGLPSPPPVAMPVFSTTRYPSLPGPSTPDHSRPVVAPLVHMRSGFPPVSHPIILGSSTPSPIAIPVSSMLRSPSLRPPSIPGLPSPSPVAMPVFSTTRYPFITTPAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HR64</accession>
    <name>A0A8J2HR64_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Similar to Cp190: Centrosome-associated zinc finger protein CP190 (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HICCMSTLAB_LOCUS13397</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5108758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HR64"/>
    <dbReference type="OrthoDB" id="10069414at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24394:SF29">
        <property type="entry name" value="MYONEURIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24394">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="BTB" evidence="9">
        <location>
            <begin position="65"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="525"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="560"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="168"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="269"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="790"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="168"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="273"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="287"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="306"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="323"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="795"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="812"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="835"/>
            <end position="849"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAG5108758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="849" mass="96874" checksum="DB27315EE94B7018" modified="2022-05-25" version="1">MQCVSKLEYPNWQLILIINCRASIMSTILQNKRSQSPGLKQVKVDNWGSFFLQRLQQLYHEEELLDLTIKFPTSDITVQAHRLVITTCTDYFMQLERKQKEKEDYDGVLVMPPDMPYECVKSIISFMYTGHLEYWTSEQNALYKTAQKMNMAVLTKLLDAQFNTSNLQTSPVTNEKTSVSLQSKVVSPNKKTSIHQTMPTTTLPGRKLPIWRRKIDSPSMNDSGSYGHRHNEANSGPSRFDLPEVEDIALGVFSSFDDITYNTKPIVRATSDSNDKKNENRSSRNDTDDDDEEKNWDNNSDDDWISTKSNSRSQDGASASKRVRFELEEKENLEKSKNSSQSSPESINNHAKIIREVLKKYPHLVKNNKNIRLKIMQKEPKSSESSSSKTKVSYVVLKSDHLIPDATESEEKNDGNDSGPWKCHKCDLDEEYHNYYMYRRHMQDVHDEKFDPRVCEHCGYKAAKRNILMYHLYTKHNVPPPMSMSFPKCHACNYVALSETLLVRHQINHKHRPLSLSRSSVSDEIQCVQCGEAFKDVSELANHEINTGHGTTMNGKDKGFRCPYCHKVFVRSTNLRVHIDCQHKKQEAMPAESEMLPSIPLEPSSEAEALSNVASGIAASLGVGDTITTETITSDHQEIHTTETSYVVNEMDLNNITHEEAFNGHGQQMIMLIDNDTYQQGELSQEVHSQQPQQIHISSNEQVVMQNTEEGGMIVYIHGTDDSSSQAYATYQTVASHDTEEIVEEVVEEVLEEGDTDHSDQNVVEGEDGNQEQVEEVIQYVEEETEIVEYDEEQSQSNDGNQQAQEPMMIIEEEHLERVESANEEETKPKMSSDLAEEWDEDSMEMAES</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HRG3</accession>
    <name>A0A8J2HRG3_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similar to TBC1D14: TBC1 domain family member 14 (Bos taurus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS13031</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5108025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HRG3"/>
    <dbReference type="OrthoDB" id="294251at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005773">
        <property type="term" value="C:vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.80:FF:000006">
        <property type="entry name" value="TBC1 domain family member 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.750">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050302">
        <property type="entry name" value="Rab_GAP_TBC_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219">
        <property type="entry name" value="RAB GTPASE-ACTIVATING PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219:SF15">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER 12 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="1">
        <location>
            <begin position="72"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5108025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="355" mass="41309" checksum="F5C031DE65B19FF3" modified="2022-05-25" version="1">MHEKNESSTINFIKNIFSSRRISLPITVPTNTIVNNININNNINNSKNVINVISSLGLILQSRPPNLPAKNSREELLHRKQYDALLDAIKKRELRKERDYQKRRAQQLEDENKLSSNLQYWDQKIIPNFNQIKSTAEVRELWWFGIPSAVRGRIWRLAVDNNLNLTAETYTGAYCIFKPEIGYVQGMSFIGAMLILNMDTPDAFICLANLFNNNLYHNTAFTLNQIKINKYWTIFNELLSRNLSCLHKHFLEINLTPDFYLLDWLFTIYAKALPLDVTSRIWDVFVRDGDEFLFKTAIGILMLYKNELFSMDFVHAAQFLIKLPDTIKVDEMFKCIKSVNIEIAGKTFDQIILSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HSF2</accession>
    <name>A0A8J2HSF2_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Similar to ttv: Exostosin-1 (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">HICCMSTLAB_LOCUS12438</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyltransferase 47 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5106794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HSF2"/>
    <dbReference type="OrthoDB" id="1924787at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015012">
        <property type="term" value="P:heparan sulfate proteoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004263">
        <property type="entry name" value="Exostosin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040911">
        <property type="entry name" value="Exostosin_GT47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015338">
        <property type="entry name" value="GT64_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48261">
        <property type="entry name" value="ACETYLGLUCOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48261:SF3">
        <property type="entry name" value="EXOSTOSIN GLYCOSYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03016">
        <property type="entry name" value="Exostosin_GT47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09258">
        <property type="entry name" value="Glyco_transf_64"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Exostosin GT47" evidence="13">
        <location>
            <begin position="86"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl transferase 64" evidence="14">
        <location>
            <begin position="450"/>
            <end position="692"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF03016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF09258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CAG5106794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="711" mass="82889" checksum="76DC83CAD8EB7512" modified="2022-05-25" version="1">MQAKKRYLLLFVTCAFLGYCYFGGYRLKSKKRNEITHDYWDKFPSYLSINEEFYDKDLKISNSKLSVVHPARQCRMETCFDYTRCKQGFSVYVYPIEDTISPLYQKILNVITESRYYTSDPTRACILVLALDTLDRDPLSTEFVHNLPSKLMRLPHWNEGRNHLIFNLYSGTWPDYIEDALAFNIGYAMLAKASMSISMLRPNFDVSIPLFGKQHPERGGEPGQAAENNFPSNKKYLAAFKGKRYVHGIGSETRNALYHLHNGKDLVFVTTCRHGKSWRELQDEHCQQDNQEYDTYDYEVLLLNSTFCLVPRGRRLGSFRFLEALKAGCIPVILSNGWALAFHDRIDWNQAVIFTDERLLFQIPDILRSVSNTQILKFRQQTQFLWERYFSSIEKIIFTVFENIRERLPWEGAREKLIWNTYPGALAILPQFADSQQELPFSNNDPGNAFTAIIYSQLGSTAVLYRLLRSVAKSKYLDKIILMWNSDIPVPRRPRWQGIKVTITVIVASSISQRFYPYPQIETSAILSLDEDVTLNTDEIDFAFVVWQSFPDRIVGYPARSHYWDDSKRSWGYTSKWTNDYSIVLTGAAFYHRYYNTLYTESLSSTLHKTVEQSQNCEDILMNFLVSHVTRRPPIKVTQRKLYKDTTAAGIRSSWNDPDHFTQRQTCMNTFVAVFGYMPLLRSNMRLDPVLFKDPVSNLRKKYRQIELVSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HSZ8</accession>
    <name>A0A8J2HSZ8_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Similar to dlg1: Disks large 1 tumor suppressor protein (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HICCMSTLAB_LOCUS12784</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5107519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HSZ8"/>
    <dbReference type="OrthoDB" id="78824at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016323">
        <property type="term" value="C:basolateral plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031594">
        <property type="term" value="C:neuromuscular junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098839">
        <property type="term" value="C:postsynaptic density membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098609">
        <property type="term" value="P:cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007268">
        <property type="term" value="P:chemical synaptic transmission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045197">
        <property type="term" value="P:establishment or maintenance of epithelial cell apical/basal polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043113">
        <property type="term" value="P:receptor clustering"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097120">
        <property type="term" value="P:receptor localization to synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099072">
        <property type="term" value="P:regulation of postsynaptic membrane neurotransmitter receptor levels"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00071">
        <property type="entry name" value="GMPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06795">
        <property type="entry name" value="PDZ3_Dlg1-2-4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11861">
        <property type="entry name" value="SH3_DLG-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001402">
        <property type="entry name" value="Discs, large homolog 3 (Drosophila)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.42.10:FF:000001">
        <property type="entry name" value="Disks large homolog 1 isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.63.10:FF:000001">
        <property type="entry name" value="Disks large homolog 1 isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.63.10">
        <property type="entry name" value="Guanylate Kinase phosphate binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008145">
        <property type="entry name" value="GK/Ca_channel_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008144">
        <property type="entry name" value="Guanylate_kin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020590">
        <property type="entry name" value="Guanylate_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050614">
        <property type="entry name" value="Synaptic_Scaffolding_LAP-MAGUK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23119">
        <property type="entry name" value="DISCS LARGE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23119:SF51">
        <property type="entry name" value="DISKS LARGE 1 TUMOR SUPPRESSOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00625">
        <property type="entry name" value="Guanylate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00072">
        <property type="entry name" value="GuKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00856">
        <property type="entry name" value="GUANYLATE_KINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50052">
        <property type="entry name" value="GUANYLATE_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 5" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="PDZ" evidence="8">
        <location>
            <begin position="8"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="6">
        <location>
            <begin position="122"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="Guanylate kinase-like" evidence="7">
        <location>
            <begin position="318"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAG5107519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="509" mass="58058" checksum="29E3327AA3423853" modified="2022-05-25" version="1" fragment="single">IHYSEVRTVILNKGTSGLGFNIVGGEDGEGIFISFILAGGPADTSGELRRGDQILSVNGINLRTATHEEAAAALKGTGQTVTIVVQYKPEDYNRFEAKIHDLKQQLSQQNLTTGTLMRTSQKKSLYVRALFDYDPNKDDGLPSRGLAFRYGEILHVTNASDDEWWQARRVTPHGDEEGLGIIPSRRRWERKQRARDRSVKFQGHMPVILDKQSTLDRKKKNFSFSRKFPFMKSKDDKSEDGSDQEPFMLCYTQDDTNTEDLSSVAGSKEILYRVELPYMEELTLVYLEKEDDENNVDLCSEENVLSYEPVQQMTIQYTRPVIILGPLKDRINDDLISEFPDKFGSCVPHTTRSKRDYEVDGRDYHFVASREQMERDIQNHLFIEAGQYNDNLYGTSVASVREVSEKGKHCILDVSGNAIKRLQVAQLYPIAIFIKPKSVESIVEMNKRMTEDQAKKTYERALKMEQEFGEYFTAVVQGDTPEDIYVKVKEVIAEQSGPSIWVPSRDQQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MAM2</accession>
    <name>A0A8J2MAM2_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similar to Hmcn1: Hemicentin-1 (Mus musculus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS2893</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001117">
        <property type="protein sequence ID" value="CAG5078973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MAM2"/>
    <dbReference type="OrthoDB" id="7613723at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042495">
        <property type="entry name" value="PDGFRL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15360">
        <property type="entry name" value="PLATELET-DERIVED GROWTH FACTOR RECEPTOR LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15360:SF4">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ig-like" evidence="1">
        <location>
            <begin position="162"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="499"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5078973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="499" mass="56210" checksum="CF4842CA5A033416" modified="2022-05-25" version="1" fragment="single">SQPTTRFINELFFVGEYIYTSELTIKNVSDEDVGEYKCYFYGSSVPQIAKANLQLHAKKYLNVTMKSLKGLDGIKKELGRSLGQYIPIYAYPYPTIKWLDPKGNEIHNDWKPWNHHFNGEYIVVRLSKNNLTLDDEGNHTLIISNPAKTVTHSFFVTIITKPKIINQPKSIPFNEVLQNFSVSADCEAEGKPVPRISWNYTNNLYNMEKNSPEDSVKITSTADGVNKIKSEIEVNVQKTGKLICKACNEAGCVSSVAKIINVPVSMKVGPGVPTTFRSISLTVGDPLTIECKSSKNMTFFSPEFNKKVVTSKENLKDTMVNNGPIVKFELRQTVYRDSGWYGCANLPMKYFTPAQTTDHLFIEDPFLYQDSKGKYYVNGEVGKDVLLPCRPSSPNYQVKLYSAGKVIDAEFDPIKGMMIKNLTANSPIDYACVIQLDNGLKKSMDFEIEKPDRPNDLEKPKIVTRSLNNTIIGGTIEIDCTVSVWSNNDYILTWVMPLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MCS0</accession>
    <name>A0A8J2MCS0_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Similar to SF3A3: Splicing factor 3A subunit 3 (Homo sapiens)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HICCMSTLAB_LOCUS3337</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SF3A3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5081622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MCS0"/>
    <dbReference type="OrthoDB" id="2160351at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000690">
        <property type="entry name" value="Matrin/U1-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051421">
        <property type="entry name" value="RNA_Proc_DNA_Dmg_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025086">
        <property type="entry name" value="SDE2/SF3A3_SAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031774">
        <property type="entry name" value="SF3A3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024598">
        <property type="entry name" value="SF3a60/Prp9_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021966">
        <property type="entry name" value="SF3a60_bindingd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12786:SF2">
        <property type="entry name" value="SPLICING FACTOR 3A SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12786">
        <property type="entry name" value="SPLICING FACTOR SF3A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13297">
        <property type="entry name" value="SDE2_2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16837">
        <property type="entry name" value="SF3A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12108">
        <property type="entry name" value="SF3a60_bindingd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11931">
        <property type="entry name" value="SF3a60_Prp9_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50171">
        <property type="entry name" value="ZF_MATRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Matrin-type" evidence="11">
        <location>
            <begin position="405"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="340"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="340"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAG5081622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="500" mass="58334" checksum="FDB301AB7354B216" modified="2022-05-25" version="1">METLLEQQRRYHEERERLMDAMVKELLHKKPGHRDNVNSEHRLKMLLQQYMECAMQLQDLYEDKDGQRKEEVQALSGPNEFSEFYNRLKSIKDFYRRHPNEISVPMSVEFEELAKMRENPTEELANWIEFTDEEGYGKYLDLHECYEKYINLKGIEKIDYITYLSTFDHLFDIPRERKNADYRRYLDALLIYLSDYIERIKPLHNLNNELEEARKEFEVQWEQNTFPGWPKETGSALTNVGAHLDLSAFSSWEELASLGLDRLKSALMALGLKCGGTLEERAQRLFSTKGEASLDPNLLAKSKNKKAGKGKDMAKQKEVASLEAQVYRLAEIVSTQRVATKENVQRKQARTEGERGDSDAEASASESEEEDDNEVPYNPKNLPLGWDGKPIPYWLYKLHGLNISYNCEICGNFTYKGPKAFQRHFAEWRHAHGMRCLGIPNTAHFANVTQIEDALALWEKLKAQKQAERWQPEQEEEFEDSLGNVVNRKTYEDLKRQGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MGR5</accession>
    <name>A0A8J2MGR5_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Similar to Fbxl16: F-box/LRR-repeat protein 16 (Rattus norvegicus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS5684</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5090578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MGR5"/>
    <dbReference type="OrthoDB" id="10044893at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22127">
        <property type="entry name" value="F-box_FBXL16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050648">
        <property type="entry name" value="F-box_LRR-repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006553">
        <property type="entry name" value="Leu-rich_rpt_Cys-con_subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13382">
        <property type="entry name" value="MITOCHONDRIAL ATP SYNTHASE COUPLING FACTOR B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00367">
        <property type="entry name" value="LRR_CC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5090578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="310" mass="33975" checksum="AD29F7B876025D95" modified="2022-05-25" version="1">MERVTNVFCGGGGGGGGGGGVAYMSIQNTNANQIPEKPSRSIPMSISNSINVVNSKSSSNTSTAVRTKIGRGKIRMRNISFASCGTPGYIPPISWEQLMLDELFLSRFFLYFNVSERKILAQVCTRWRDVLYARPRFWAGLVPVVRCREIRGMASGSRTKLYASLVRRGFHSLVLLGAADEDIPELTHGFPMAQRHIHSLSLRCCSVTDRGLETLLDHLQALFELELAGCNEVTEAGLWACLTPRIVSLSLSDCINVADEAVGAVAQLLPSLYEFSLQAYHVTDAALGYFSAKQSSSLTFLPYFCCKVQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MHU1</accession>
    <name>A0A8J2MHU1_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Gustatory receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HICCMSTLAB_LOCUS4035</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Cell membrane</location>
            <topology evidence="1 8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the insect chemoreceptor superfamily. Gustatory receptor (GR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5084173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MHU1"/>
    <dbReference type="OrthoDB" id="6366728at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030425">
        <property type="term" value="C:dendrite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043025">
        <property type="term" value="C:neuronal cell body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007635">
        <property type="term" value="P:chemosensory behavior"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008049">
        <property type="term" value="P:male courtship behavior"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050909">
        <property type="term" value="P:sensory perception of taste"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013604">
        <property type="entry name" value="7TM_chemorcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21143:SF133">
        <property type="entry name" value="GUSTATORY AND PHEROMONE RECEPTOR 32A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21143">
        <property type="entry name" value="INVERTEBRATE GUSTATORY RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08395">
        <property type="entry name" value="7tm_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 8 9" id="KW-0675">Receptor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="70"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="105"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="159"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="192"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="272"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="308"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="389"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAG5084173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="425" mass="49095" checksum="61275EFFA03F1C39" modified="2022-05-25" version="1">MQPNSFHSYKTKKRNNSSSTIYRESLIFQLILFKLFGLAPWSMNVSKIIGKNIPITLQNYLILDSSLYGAAYNILLIIIWIIYNVYSSLIVVYEKKKFESLITKTVAMNLIIFSMVSPIFMWIFYLVHQRIIITVINKLMHIDKTLHRYSAYLSIKNNAVFLIFLTNFVLYNCYVISLMCAHPMIVVPIRSIPSLISSLILIQYSMILDAFYKQFNNINLIILQLSGVNPNIELQKLFVSKMPLRRPIRGDIDHLNRFHAELCDMCGKVSKFYGLPVLLTILYFSAASILLLYYIFIFFSNPLTRFQVFLYLGDAAVFSIMIFGFIVMTFSVNRVIKESKKTSFMVHLILDRCTMDDKLENQLIEFSFDLLHRKVEFTACGIISLDGSLLQSVLGTIVTYLVILIQFYRGGSSNDPEKLQTFPPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MIP7</accession>
    <name>A0A8J2MIP7_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="19">Integrin alpha PS-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">HICCMSTLAB_LOCUS5532</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Membrane</location>
            <topology evidence="1 14">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the integrin alpha chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5090205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MIP7"/>
    <dbReference type="OrthoDB" id="5317514at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009897">
        <property type="term" value="C:external side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008305">
        <property type="term" value="C:integrin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005178">
        <property type="term" value="F:integrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048513">
        <property type="term" value="P:animal organ development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033627">
        <property type="term" value="P:cell adhesion mediated by integrin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007160">
        <property type="term" value="P:cell-matrix adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007157">
        <property type="term" value="P:heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007229">
        <property type="term" value="P:integrin-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.930:FF:000001">
        <property type="entry name" value="Integrin subunit alpha V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.930">
        <property type="entry name" value="Bicelle-embedded integrin alpha(iib) transmembrane segment"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.130">
        <property type="entry name" value="Integrin alpha, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1460">
        <property type="entry name" value="Integrin domains. Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1510">
        <property type="entry name" value="ntegrin, alpha v. Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1530">
        <property type="entry name" value="ntegrin, alpha v. Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013517">
        <property type="entry name" value="FG-GAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013519">
        <property type="entry name" value="Int_alpha_beta-p"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000413">
        <property type="entry name" value="Integrin_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018184">
        <property type="entry name" value="Integrin_alpha_C_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013649">
        <property type="entry name" value="Integrin_alpha_Ig-like_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048285">
        <property type="entry name" value="Integrin_alpha_Ig-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048286">
        <property type="entry name" value="Integrin_alpha_Ig-like_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028994">
        <property type="entry name" value="Integrin_alpha_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032695">
        <property type="entry name" value="Integrin_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23220">
        <property type="entry name" value="INTEGRIN ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23220:SF122">
        <property type="entry name" value="INTEGRIN ALPHA-PS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01839">
        <property type="entry name" value="FG-GAP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08441">
        <property type="entry name" value="Integrin_A_Ig_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20805">
        <property type="entry name" value="Integrin_A_Ig_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20806">
        <property type="entry name" value="Integrin_A_Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01185">
        <property type="entry name" value="INTEGRINA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00191">
        <property type="entry name" value="Int_alpha"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69318">
        <property type="entry name" value="Integrin alpha N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69179">
        <property type="entry name" value="Integrin domains"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51470">
        <property type="entry name" value="FG_GAP"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00242">
        <property type="entry name" value="INTEGRIN_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 14" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 14 19" id="KW-0401">Integrin</keyword>
    <keyword evidence="9 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="11 14" id="KW-0675">Receptor</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="103"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1080"/>
            <end position="1102"/>
        </location>
    </feature>
    <feature type="repeat" description="FG-GAP" evidence="13">
        <location>
            <begin position="22"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="repeat" description="FG-GAP" evidence="13">
        <location>
            <begin position="197"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="repeat" description="FG-GAP" evidence="13">
        <location>
            <begin position="317"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="repeat" description="FG-GAP" evidence="13">
        <location>
            <begin position="378"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="repeat" description="FG-GAP" evidence="13">
        <location>
            <begin position="439"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="domain" description="Integrin alpha first immunoglubulin-like" evidence="16">
        <location>
            <begin position="508"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="domain" description="Integrin alpha second immunoglobulin-like" evidence="17">
        <location>
            <begin position="662"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="domain" description="Integrin alpha third immunoglobulin-like" evidence="18">
        <location>
            <begin position="810"/>
            <end position="1066"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1117"/>
            <end position="1136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="1120"/>
            <end position="1136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU003762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF08441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF20805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF20806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="CAG5090205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="1136" mass="127625" checksum="F4D4B42A91A1EEF8" modified="2022-05-25" version="1">MKLPWIIFVLIYGALGFNLEWRIPVIKRGRSDSYFGYSVAEHQEILEDDNKSISWILVGAPLDQNRQPGTNRSGALWQCPLTTKTNDCEQVITDGRLKNKYSIYFVIFFFFFYIFYGHLLCSFLLNESYVDSDELIPPGNDEIKDGQWLGVTVRSQGAGGKVMVCAHRHIVKTADSQWGQGQCYILTQDLKYDDIKKPCSGKPTSKAHEQFGYCQAGTSGILTPEDRVVIGTPGPHTWRGTMYVFTVSDEFLQRDNTVYNAPMQDASPVNKYSYLGMSVTVGNFFGKGLAYASGAPRSNGTGQVVILTRQHSRPDMDVALILNGEQFASSFGYEIAAADVNGDKNTDLIVSAPFYFNKAEGGAVYIYTSLCRHNKDSDKCKPTKLVGREESRFGFALTNLRDLNKDGYEDIAIGAPYEGKGTVYIYLGSKSGIITTPSQVIHAEDTPVPLRTFGYSLSGGIDMDKNGYPDLLIGAYDNDAVALLRARKIIDITTSVRYARKDGTYQEKIEAVDPNKIGCSADPTSNHTCFAFEACCKTESLTRNEGMVNLKLNYHIEAETYSGVKKFSRVWFGFGKNKPHYINRTVTLDPTKSMHCQREIVYLKENTRDIQSPIKFRLNYTLIQEEPVMPREGNPLPDINNYPILNQQEAARIFEATFQKDCGDNEICESDLQVDAKLNLSASVVKPNFYELLLGEVEEVVVDVSAVNIGESAYEAQLFISHSPSLNYIASKSNESIICNLHNSTLVICSIGNPFRKDNAVNVQVRFDPKGVEDNEPQLNFVIFANSTSKEVQEKQPIRLQAIVLKRAELSIKGSAKTQWAYYGGPIVGESAIKHLNEVGPKVSHLYEVFNEGPWKVRTVEVVISWPYEVANDKKHGKWLLYLEEMPTVSHAGDGECILPTGYVVNPLKLLGSVSYDDLDPFPSTTSSPVNYYRNRTINHIRDRRDIEKVVSTRMMTDRDGHSRQIVSMNCKTGTAKCFDIRCIIYNLQRKQEATITVKARYVFLNSVFIIHLLFNELWNSTLVEDYPKVDQVKIGSNAKIVIPPSIEIQQENLKNDHATAETIAYPDLGDQQDSEPVPIWIIIVAICAGLLLLILLTLILWKLGFFKRRRPDPTLSGNLEKHRDDNPEHEALFKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2ML41</accession>
    <name>A0A8J2ML41_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS6716</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5093275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2ML41"/>
    <dbReference type="OrthoDB" id="8035095at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="299"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="304"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="330"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="358"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5093275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="370" mass="41418" checksum="1F835323585A5CBF" modified="2022-05-25" version="1">MSDHTEEQLENGGSNGGHTLKRHREEDSSGSSDSERSRALSLPPLLPRKRRRFSDTSREIRALHEKVELLSDLLLQKQNAPEPPVVSMPATAPQTSVLNLGQCKTEVDAKKLVQQADPESLKTLCDLQRFGLPDWKEIRYSNTLKEFLASPGFSELKVNEELCYLDKAKDPVLSTERVLAGLSNAVLTQSSILQNTLQGIVEWARSIEGGVSPELLLSMFSLNFGPESEMFKNSQKMLQIICGKRASCIEARRERILTEAPNKQVQGALRRIPPSSEHLFGKENLSTLITSLGGAQTWLKEPSHSSSRHGNASSSRTSKRDNFRTDYQPRPSQVSGNKPDQQRTSFKPRFPKKDSAKPRHSGSFRKKFEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MNF8</accession>
    <name>A0A8J2MNF8_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS7134</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5093808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MNF8"/>
    <dbReference type="OrthoDB" id="6349518at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017080">
        <property type="term" value="F:sodium channel regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002028">
        <property type="term" value="P:regulation of sodium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031578">
        <property type="entry name" value="TipE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12335:SF7">
        <property type="entry name" value="RT03134P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12335">
        <property type="entry name" value="TIPE PROTEIN TEMPERATURE-INDUCED PARALYTIC E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="381"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5093808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="449" mass="49680" checksum="F3DC99ECCE83AE57" modified="2022-05-25" version="1">MGKPTPVEDLVIPPQDGRICGTICICQMTAVLSSVALVYLTVAIYMPSTRAFSSGISPVPAMCTTIRTVNADNCSWGSCGEWCLSKTSGPCTQIHVNLRNNGSTILLGNCTNITNKTCYGIDQENAKKSKCIADECRNLTGTFNCTAGICINITDAFECNFRDTDPPLKCSGRRGKITCIAIDGLFNCNRGTCERIRTPYNCDRRCVDIPTRNKNMILISGDKVYLSQCERAIDVESSKEIWNENRGDVLMASCYGIYNSSLGVEAVDCINGSVLEKTMLTDLTNFTYLSYLSLYASKPLDDANFALPPEHTLIIANESRLMINLEGCVNTLRDECKEFLHEFGKDGSDHNARARFPCFFAKDRTEIVVSKFDLETTWKEFIVALVFPSVLFVVSCLTLILCQRTVVVGDDAKMRFKGIPIAKSELDKSIPLLEESPARQSIFSLRGHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MNQ6</accession>
    <name>A0A8J2MNQ6_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Similar to Negr1: Neuronal growth regulator 1 (Mus musculus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HICCMSTLAB_LOCUS9028</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5098091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MNQ6"/>
    <dbReference type="OrthoDB" id="5359219at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032589">
        <property type="term" value="C:neuron projection membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050808">
        <property type="term" value="P:synapse organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013106">
        <property type="entry name" value="Ig_V-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037448">
        <property type="entry name" value="Zig-8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23279:SF37">
        <property type="entry name" value="DEFECTIVE PROBOSCIS EXTENSION RESPONSE 13, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23279">
        <property type="entry name" value="DEFECTIVE PROBOSCIS EXTENSION RESPONSE DPR -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07686">
        <property type="entry name" value="V-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00406">
        <property type="entry name" value="IGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035188248" evidence="2">
        <location>
            <begin position="22"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="3">
        <location>
            <begin position="56"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="3">
        <location>
            <begin position="158"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="28"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG5098091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="298" mass="33022" checksum="00C6C932F4D116C0" modified="2022-05-25" version="1">MRIALILVTLVFEINLYFTESKAMQQQQQQQQQQQQQQKKTNGDNALVSANENNKPAEQVVGARAREIVAQKGGTATLPCKFSEPGAGIVTWVRRRDRQLLTVGTATHSVDTRFMIRVSSADWALVIRHVTLDDAGLYECQIATYPVEQHFVRLAVTEAYSVIPGGPDLHVKQGSSLKLECQLMAATEPPNFVFWYLQGRMINYDADPLVKVELTENGSILKVDKIKTTHGGNYTCLPSNAEASSVNIHVIEEEEKPAAMHGGDRRNPSPVILASNFLASLLATVSWRIPTFSSLYPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MNW0</accession>
    <name>A0A8J2MNW0_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS9180</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5099679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MNW0"/>
    <dbReference type="OrthoDB" id="6436078at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035251809" evidence="2">
        <location>
            <begin position="20"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5099679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="195" mass="22890" checksum="F6C09B2AE0C40CE9" modified="2022-05-25" version="1">MFVIVKWIISAIIVLEVQASWKLQVQSHKPTTRVKNYQKFPLFINEHPKNNIEHRSYPYAVPYSSRPLYRLAGKPYGFLRKRRPGIPAVFLRPPQIKKNRNRGFKSTKQKRPQKPRDSPKENFSEDNSKEEEYIRDHDPAQQTIEEVKDDTAEYDDSDNYIEEKLKGSDEDRVDFHVHGHQGPDSYIFGFDTGKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MPA3</accession>
    <name>A0A8J2MPA3_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similar to Efl1: Elongation factor-like GTPase 1 (Mus musculus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS9304</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5099927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MPA3"/>
    <dbReference type="OrthoDB" id="364892at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042256">
        <property type="term" value="P:cytosolic ribosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42908:SF3">
        <property type="entry name" value="ELONGATION FACTOR-LIKE GTPASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42908">
        <property type="entry name" value="TRANSLATION ELONGATION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="EF-G C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="2" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Elongation factor EFG" evidence="1">
        <location>
            <begin position="4"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5099927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="128" mass="14467" checksum="D54C5A80C9358942" modified="2022-05-25" version="1">MIAGKLYAVFGRRHGRVIAADNALGFGGQFQVEAILPVPESFHLARELRTQTSGLATPQLVFSHWEVIEQDPFWVPSTEEEYLHFGEKGDSVNRAKKYIDAVRHRKGLPVDSQLVTHAEKQRTLSKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MPQ3</accession>
    <name>A0A8J2MPQ3_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Similar to Brwd3: Bromodomain and WD repeat-containing protein 3 (Mus musculus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HICCMSTLAB_LOCUS9637</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5100564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MPQ3"/>
    <dbReference type="OrthoDB" id="10265743at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007010">
        <property type="term" value="P:cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052060">
        <property type="entry name" value="Bromo_WD_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057451">
        <property type="entry name" value="BRWD/PHIP_AD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16266:SF17">
        <property type="entry name" value="BRWD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16266">
        <property type="entry name" value="WD REPEAT DOMAIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25313">
        <property type="entry name" value="BRWD_AD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="35"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="138"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="218"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="Bromo" evidence="7">
        <location>
            <begin position="888"/>
            <end position="938"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="526"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="530"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="564"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="584"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="599"/>
            <end position="610"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG5100564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="948" mass="108123" checksum="D57142B0BA562E63" modified="2022-05-25" version="1">MDIAVNFNNTLLAAGSLDRILRIWCFQTMSPIAVLCGHSGMVTSVNFCPITCNGVNYLVSTSTDGSVAFWSYTQKSNERAVFQPKPIQYHEKMRPGQAQMICASFSPGGTFMAAGSADHHVRVYSMLEEEGPRRVLEVEAHTDTVDSIQWAHMGLKFISGSKDGTANVWHFEQQQWVHKRLSMNTKLSDDVKVDEDTIKKAKVTMVWNAKSGELMKILRGHKDEVFVLEAHPIDPQVILSAGHDGQLIVWDVLNSEPIACFQNFIEGQGNGAVFDAKWSPDGTMLAATDSHGHLLMYGFGSGVEKLKIIPKELFFHTDYRPLIRDSNNYVLDEQTQTAPHLMPPPFLVDVDGNPYPPSLQRLVPGRENCRGEQLVPNIAVGVGGLQEVIEGIPDPEPRSNIDRLIEALAQRQNLNTGDNENIDDREENFNESQIRQITSPRGNRLGLRRVGDVEGVRQSSGNWQRDNTTPWNKPILVPPIHEAIQQTQLEKLYSMADMEIEIWKREMKKRPLPPVKLVEASDHANNYLTNRKRKNGVRHGYRTRAARDDEQNDDENNSENRELSGTSESSHSNDSSAHEEDLCSDTTTSDTSSEYSDWIADHGLHLEPPTRSKRKPMNKRSVTPSTDLNKQRNQRLKKKLMTVPNGTAEVPDVFRPSEWLTEVIPRKAPYYPQIGDEVVYFRQGYNLYFDAVKNKKVYSLSTRCEPWSKMEIKAHEFVKVVGIKYEIRPPRLCCLKLALMDEEGHLTGNTFTIKYHDMADVLDFLVLRQTFETALNRNWSEGDRFRCMIDDGWWMGEIESMEPLDEEFPESYFMCFRVRWDNGEYEKMSPWDLEPIDAERLPIEIGGAVPVLPEEIQNTLYQPQPDEWPMGDREATCRRIVRGIDQVMSLAIAEPFITPVDLNIYPAYAFVVEYPIDLSTIKTRLENHFYRRIISAQFDRTGRSVRTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MPY2</accession>
    <name>A0A8J2MPY2_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="20">Similar to nAChRalpha1: Acetylcholine receptor subunit alpha-like 1 (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">HICCMSTLAB_LOCUS11085</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="16">Postsynaptic cell membrane</location>
            <topology evidence="16">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5102578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MPY2"/>
    <dbReference type="OrthoDB" id="5975154at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045211">
        <property type="term" value="C:postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005230">
        <property type="term" value="F:extracellular ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098655">
        <property type="term" value="P:monoatomic cation transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007271">
        <property type="term" value="P:synaptic transmission, cholinergic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd19064">
        <property type="entry name" value="LGIC_TM_nAChR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.390:FF:000001">
        <property type="entry name" value="Neuronal nicotinic acetylcholine receptor subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.390:FF:000022">
        <property type="entry name" value="Nicotinic acetylcholine receptor subunit alpha4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.390">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006202">
        <property type="entry name" value="Neur_chan_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036719">
        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038050">
        <property type="entry name" value="Neuro_actylchol_rec"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006029">
        <property type="entry name" value="Neurotrans-gated_channel_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18945">
        <property type="entry name" value="NEUROTRANSMITTER GATED ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02931">
        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02932">
        <property type="entry name" value="Neur_chan_memb"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90112">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane pore"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="15" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="14" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="9 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-0628">Postsynaptic cell membrane</keyword>
    <keyword evidence="11 20" id="KW-0675">Receptor</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0770">Synapse</keyword>
    <keyword evidence="4 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="68"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="103"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="133"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="280"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel ligand-binding" evidence="18">
        <location>
            <begin position="2"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel transmembrane" evidence="19">
        <location>
            <begin position="74"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel transmembrane" evidence="19">
        <location>
            <begin position="237"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00034104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF02931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF02932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="CAG5102578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="333" mass="37440" checksum="CE76433C8834B637" modified="2022-05-25" version="1">MNNVDLRHLSQTEDSNEIEVGIDLADYYISVEWDILKVPAKRNEKFYSCCEEPYPDIIFNITLRRKTLFYTVNLIIPCVGISFLSVLVFYLPSHSGEKVSLSISILLSLTVFFLLLAEIIPPTSLTVPLLGKYLLFTMVLVTLSVVVTIAVLNVNFRSPVTHHLPGLPVTIPPVPVPPSVTTIPNSRYGDLPIPVVAPRFDESALPPIPLPGGGDDELFVPASPGYVHDDASPTFERPLAREIEKTIEDARFIAQHAKNKDRFESVEEDWKYVAMVLDRIFLWFFTIACFFGTALIILQAPSPYDETKPIDIIYSKIAQRKMMLKNMGPEEDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MQ54</accession>
    <name>A0A8J2MQ54_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Similar to CG43427: Uncharacterized protein CG43427 (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HICCMSTLAB_LOCUS10195</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5101122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="15627at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001725">
        <property type="term" value="C:stress fiber"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032034">
        <property type="term" value="F:myosin II head/neck binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051496">
        <property type="term" value="P:positive regulation of stress fiber assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051893">
        <property type="term" value="P:regulation of focal adhesion assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08368">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031865">
        <property type="entry name" value="DUF4757"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15551:SF3">
        <property type="entry name" value="LIM AND CALPONIN HOMOLOGY DOMAINS-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15551">
        <property type="entry name" value="LIM DOMAIN ONLY 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15949">
        <property type="entry name" value="DUF4757"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00478">
        <property type="entry name" value="LIM_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0440">LIM domain</keyword>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="LIM zinc-binding" evidence="6">
        <location>
            <begin position="1588"/>
            <end position="1654"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="110"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="318"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="401"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="587"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="786"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="867"/>
            <end position="895"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="929"/>
            <end position="968"/>
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    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1020"/>
            <end position="1083"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1146"/>
            <end position="1169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1369"/>
            <end position="1394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1474"/>
            <end position="1513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="9"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="24"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="155"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="166"/>
            <end position="193"/>
        </location>
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        <location>
            <begin position="194"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="211"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="240"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="334"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="401"/>
            <end position="420"/>
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        <location>
            <begin position="427"/>
            <end position="440"/>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="467"/>
            <end position="481"/>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="541"/>
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        <location>
            <begin position="594"/>
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        <location>
            <begin position="656"/>
            <end position="668"/>
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        <location>
            <begin position="689"/>
            <end position="699"/>
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    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="700"/>
            <end position="717"/>
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        <location>
            <begin position="732"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="794"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="867"/>
            <end position="889"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1033"/>
            <end position="1051"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1058"/>
            <end position="1076"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1489"/>
            <end position="1506"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAG5101122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="1657" mass="187518" checksum="F7710ABE466D57EA" modified="2022-05-25" version="1">MPSSQNAATERRNDRMISHEPPKLKTTLKTSPKQATNPLQFVKVGPCSLYRTAQEQLQKVQEVKKVKQEVRDDPEDWQSNLDNWKSSRRKRQEHIIERVVEVKKLELEEHDRHRRRSKTFSEMMEERSSRGRKLSMSLAMYHEEDSNDLSDLGIGTSSGKSSVSGDTHDDTQSVLSDRDSEIDKNHSDLDNASHENGNTNENNNMNAVPPSVTSITKTAISKKSPQFGNGFQDDQREYDSGTTATTSSPEPDEYNYEGAIRYNRAPPQTLPRTSLLKHDPKLDSKPIINYEESAGGSDKSVPVVKVDILKRREIFEKAAQKTADNKVNNNNGNRSSGEFSSPVSIKERLMSLEKQTIETSEDEDKNSKVIDRLSGDMTTIRERLSFLEKQVSVRETKISSRKLSNDEFEPVRPLRERLSTLEKYASSDESSSTPRSSSPDSEYRAPRATFHQSLDSLDADASSEPDTFDRVQSLEELDYVRRRYPTSVSSAEILNDTDREDSGIHTADASCSVSQSDEPVDEEVAPVHHGTSITIEVKPPVPKDRNVKGEDDLGDKVTDECNQIKTEEDFQSEADQEKVIQLESAVIIEGTAESPGNTLPTNKSQIEQQPTKPTSRVIVFQSPRIPPRRCPPVKSGDSSSPLLQEDSEVESKLSESKTSSAESISSTSPLKPSKIPTPLPRKPTGVTVKLSSAPNTAPTSPIKLSASSKSLPSSPFSCRHSKIPSPLKAQEDQQSASTVVSGEQSQESKNSDRRRTVFEVCEKIIVPQDVSPVLPITPFITVTKVGEDQQQLSDSEESIVTDGSSSDEEIELQCESTESVEHEEETRASEPLTSGNQSAELPLTCPNIKAATNAASPVIVVEQEIYQDSQSESVASSTPLSYETESNISDYDKPPVVSPLTMEFIDPSMSLSKSIYQLNLSNDEKIEIISPFPLGPPSSVEPPKEKPPPPPIDYSDDENQPTEPLKRLNSTRRIKKELRTRRSDFLGLEGVGDDELHLEVPKPLDMTALLAEERRIEQMNRRSYDTDSNYEQDSIHDRDSGVGLGHAEDWTKQAVSPDMSQHSRQSSEPFGASVTSSEEDEITKKEREIFEMLEKEEQWRYGNDREQNSIGLGALTLASSPDGSSLKFDIGEKLAHKLRELEEEKMQLERERAQESVALHRQDEPLRKTEEIQPRMQEEDLLRNQQQQQQQQQQQQQQQQQQLQHLHHHQQQQQEIIVMQSEVIREEEIEFREQEKLRFDVERLKLHEDIYDQERRNEIRRQDEMHLRAIDRKIREPEHTVVNAVMCDHDDEYASGEVLRVERELLQLEQEALKRQRSNMVYREQKQQQLAEQWQSLQNVNYTGNIVHATYQNIDMTNYRSSMPNLQLQENQRRRPAPPPIPPAKPNSRIPSADSIPQQVDATIRHSASATALSTHAGQQMTKQTLNALSAVPRTRIVKNDQWVQRRKSDGPRVISQDLNYQHWLIQEAEQRRINEKNQRSPPQRKPQQHVTGTSVPYTASTTSYKSEGKPLPDSIIQTLTQRIQNRAQERPLPLRRRIDHSVSQEHLPQAHHQPSAHLAMMHQKAHQSPGTSSADSQEKLLSVSGKKKCSHCGDELGRGAAMIIESLRLFYHMECFKCCVCHVRLGDGLMGTDVRVRNHKLHCHNCYSSDDGSYYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MSE8</accession>
    <name>A0A8J2MSE8_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">60S ribosomal protein L36</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HICCMSTLAB_LOCUS9118</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subunit">
        <text evidence="2">Component of the large ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the eukaryotic ribosomal protein eL36 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5099556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MSE8"/>
    <dbReference type="OrthoDB" id="9616667at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1760">
        <property type="entry name" value="60S ribosomal protein L36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000509">
        <property type="entry name" value="Ribosomal_eL36"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038097">
        <property type="entry name" value="Ribosomal_eL36_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10114">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01158">
        <property type="entry name" value="Ribosomal_L36e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01190">
        <property type="entry name" value="RIBOSOMAL_L36E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 6" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAG5099556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="83" mass="9681" checksum="EF4F4BA42517E7E1" modified="2022-05-25" version="1">MPARFELAVGLNRGHKTTKIRVAKNKNEKERTVAVRPSRFKGRQTKHTKFQRDLVREVTGHAPYEKRAMELLKVSKDKRALKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MSS1</accession>
    <name>A0A8J2MSS1_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Similar to Shkbp1: SH3KBP1-binding protein 1 (Mus musculus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HICCMSTLAB_LOCUS12056</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the KCTD3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5106018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MSS1"/>
    <dbReference type="OrthoDB" id="6077599at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051260">
        <property type="term" value="P:protein homooligomerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18363">
        <property type="entry name" value="BTB_POZ_KCTD3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.710.10:FF:000038">
        <property type="entry name" value="BTB/POZ domain-containing protein KCTD3 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047876">
        <property type="entry name" value="SHKBP1/KCTD3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003131">
        <property type="entry name" value="T1-type_BTB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15859:SF1">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15859">
        <property type="entry name" value="SETA BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02214">
        <property type="entry name" value="BTB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="BTB" evidence="6">
        <location>
            <begin position="13"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="132"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="132"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="156"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAG5106018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="686" mass="75750" checksum="E98F3E1B31A306C7" modified="2022-05-25" version="1">MKSSLIPSLIMGDIIHLNVGGTRFSTSRQTLTWIPDSFFTALLSNRIASRRDETGALFIDRDPQIFSIILNYLRTRDIDLKSIDIRTLRHEAEYYGITPLIKRLMLCEDLTHSSCGDVLFYGYLPPPSIPLQESASVPVSTTDVGVHGRTVASPRPETSQPSTSQATPNQASNTNGPQNQKPPTSNHTRNSSLDYRLPQRGLQHSRNPSLDLRHARNSSADMNKYFRNEVGLVFGPHQASGWVDPLRVQMIKAHHNWIVIAYAHFITCYRLKDSSGWQHAFTSPHVEAIIERVAINAKMGSGADGKMVAISYGSQIRLWSVSEDGIKTNIGTFNLNVRVEYLFFIGSQLVALSPTGKIGVWHAMSQHWQIQDVVSISSFDTAGSFLLLGCNNGSIYYIENNRIIIILLEDILSLSTGLCGNWIEIAYGTKSGIVRIIVQHPETVGHGPQLFQTFTVHQSSVTKVRLSEKYLVSVCSEYNHGRSWALTRFRGMISTQPGSTPVASFKIVSLDSVDSLLSNDAGNDFGPFGEQDDEQVFVQKVVPETDQLYVRLASNGKRVCVIQSVDGSSISSFCVHECEGSSRMGSRPRRFIFTGHSNGAIQMWDLTTALDPSFESHQAKNFAGGPSPEELWKLLDQCDLSNSHCSTPCLSPCPAIVSSGPRIKASNVQFLNQLQNSESNSGPSQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MT66</accession>
    <name>A0A8J2MT66_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Chloroplastic (Arabidopsis thaliana)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HICCMSTLAB_LOCUS13355</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aldo/keto reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5108674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MT66"/>
    <dbReference type="OrthoDB" id="416253at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd19136">
        <property type="entry name" value="AKR_DrGR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.100:FF:000002">
        <property type="entry name" value="2,5-diketo-D-gluconic acid reductase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827">
        <property type="entry name" value="2,5-DIKETO-D-GLUCONIC ACID REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827:SF3">
        <property type="entry name" value="NADP-DEPENDENT OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="7">
        <location>
            <begin position="20"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="4">
        <location>
            <position position="53"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="116"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Tyr" evidence="6">
        <location>
            <position position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG5108674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="292" mass="32806" checksum="EDE82301136AD6DF" modified="2022-05-25" version="1">MNSASKYIRLSTGFNMPLVGIGTYKTTGREKIFNVLDEALGVGYHSIDTATVYRNEEDIGYALKTLLNKYALERDDIFITTKLAPSDNGNPQRIRKAVETSLKALGTSYIDLYLIHWPGTGGIPEDSIENIKLRSITWQTLIDLKSQGFLRSIGVSNYTVKHLQLLLQDCHGESPAVNQVECHPHYRQEKLLEFCNKEGIHVQAYSSLGTSNETTLLKDPIVCRVAEELNVSPARVLLKWALQQGIGIIPKATSKEHIHDNFKLDFTINETQMKALCSLPQRKYAWSPDNVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MUF9</accession>
    <name>A0A8J2MUF9_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Similar to Fancm: Fanconi anemia group M protein homolog (Mus musculus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HICCMSTLAB_LOCUS8152</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DEAD box helicase family. DEAH subfamily. FANCM sub-subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5096322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6513042at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000400">
        <property type="term" value="F:four-way junction DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009378">
        <property type="term" value="F:four-way junction helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045003">
        <property type="term" value="P:double-strand break repair via synthesis-dependent strand annealing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036297">
        <property type="term" value="P:interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18033">
        <property type="entry name" value="DEXDc_FANCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12091">
        <property type="entry name" value="FANCM_ID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000861">
        <property type="entry name" value="Fanconi anemia, complementation group M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1320.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039686">
        <property type="entry name" value="FANCM/Mph1-like_ID"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044749">
        <property type="entry name" value="FANCM_DEXDc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14025">
        <property type="entry name" value="FANCONI ANEMIA GROUP M FANCM FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14025:SF20">
        <property type="entry name" value="FANCONI ANEMIA GROUP M PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="9">
        <location>
            <begin position="42"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="10">
        <location>
            <begin position="383"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="571"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1134"/>
            <end position="1165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1216"/>
            <end position="1237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1336"/>
            <end position="1390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1406"/>
            <end position="1437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1477"/>
            <end position="1524"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1617"/>
            <end position="1638"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1134"/>
            <end position="1149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1337"/>
            <end position="1346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="1480"/>
            <end position="1496"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAG5096322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="1669" mass="190694" checksum="11ED275BB5B916AA" modified="2022-05-25" version="1">MDLLSQEPLFSTDPSTVGFDKSAGKRYIYPENYPVREYQFSIVKTALFQNTLVCLPTGLGKTFIAAVVMYNFWRWYPRGIIVFLAPTKPLVAQQIEACHDIMGIPISQTIQLTGVIHQKERKVAWHERRVIFATPQTFQYDLAKDIIPKELVKCVIIDEAHRALGKHAYCECVRLLNEKNEYYRLVALSATPGSKLEAVQEVIRNLHISRLELRDDSSPDILPYINQKNMQIVEVGMNDDFKRFYDRYMNIMDPVYRVLLKNNIIKMDISSLSKGKMFYIRNDLQKNRNKRFNYGELYNTINILSTMVYAKDLMIYHGLRTFHKFYQNHSDKPWINDKPELQDLLEEVGHYLGEFPNIQALMEGNDKAFADMNIVYGHRKYERLQEILTEYFTDAQKNNISTRVIVFSEFRESVSEIYVSLYKLQPLIRPQIFVGQAHLMKQAQQKRAIEDFRNNKVNVLISTSVGEEGLDVGEVDLIVCFDTTGKTPTRLVQRIGRTGRKRDGRVIVLVTDSKEHQTLKSALISKDNLNTKVLQSKQIREVLNDNSPRMIPDDLDPECCRMKMTVIPVTPRARSKKKSTDTKKNKTQLKRKYTKKKLKDNFEDQVEMDIDVDESISTVNKPRTKKGKQSSLMNFFQNSNASHCRDSSMQDDEVVCMRVEEVPRIIPTIISKLSTNAVRIKPIDAKILSSDLEASNFLTLCAMKESEKVLKKQTRVLNFTFMPNFMNCEEDILENLKIPSFRILDCILSLTEYVQPAEEKGDEFSEFFNDDMDNWDNDFVDYNQDRDSQADYKYGNRSNYQNKSDSSKQNELFLQKSKFEALLDDSTDEEDLYGPDEVLPAHERINLTDFLDVTNKNDQSSKEGTLNKSSVVTGGAFEDLLNTSSDESVEIIENFEKCENNLNSTRQATNVLIDVRESYIVPAINNYEADTVLIDKIETDTIPISDFEEDTRVVDLEPELQIINNVEPETALVFNLKTDTERVNNLNRDTERVNNSEADTVLVNNLEPDTVLVNNLEADTLPVTDSDTLIISKPNLIQPIKSQNTNNIEISSQVLTSSQDNFDNIDFDSDFGSWEKKVFQKNIKSQDKNIKISPVKKPENVLNGVRSSNLVKNSQSSIDNIKKPTMNKLIKMTNEEKSENKKDDCHSPDLVKSSSHRRSNQSKFNRTLDFSNKKSLEVVGESYEKIHCTTLSDDDIFDCESLVADSDLEEQLRDVEKLNSDKKSENNTGKDSENKVNQLKELDNLKSILPLSCSSPVQLKKNDRNLSLEPITVDTNLIETYVNDCDWDSDFETSSAPITECKYFGSNPSTISTTSATTSKQSTSIADKICLQKNQKENNPNWLSTKTAEKKTIQQGNSVKSKKPQKNCLPILTFNPKSRRKDSSDSDSDFAPTKIVKNVFQSRLSVGNGRTYDSPPKNNAKADSFLPKVNSPKSLSTSNLNKFAATSKVVSKLSSSKPGVQSTSSWIATKKSTSLDSFPKKQKLKEHHRKKRRRKNNFIDDEADVSSDENHSSGYSEDDDDGADLQDFVSYTQYHDNSVDMKAHYLQSVRSPRRPGKFIIKQPKPVSPEVQIYSQIIPDEPNSYLYDSFCVEDGDEALNELSSEEITVIEEVGLNKNTSRNRKRKRDVSEDTRSKRKRIIIDSDSSDDDIEVLRAQIADESILLKNKMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MUP0</accession>
    <name>A0A8J2MUP0_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Peptidase S1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HICCMSTLAB_LOCUS13494</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5108858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MUP0"/>
    <dbReference type="OrthoDB" id="7662118at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="3">
        <location>
            <begin position="46"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="540"/>
            <end position="567"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG5108858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="567" mass="64145" checksum="47D6F9CE16468DA1" modified="2022-05-25" version="1">MFILKENNREKVNPFCVPLVIVIMIMINGINVTITQTVDSIPHRELIGETPATEDTPTTEVVTDNTTVENQTDKPIVINYWMMKMGDIKEDLLGIQAVVVKDEDAEAACSEGKMRSRRRFLMCAGSILHRNRILTTASCLHEAMHIKHNIRAPLAVVIAPLKTSVQVIRVAEYKIHPEHNTNPYSPDHTKHNIAILSLACRISTVNYNKIYLPTEPMTHICTEENCVLAVYTKTRHELVIHQIQAPQIPINYRKRRSINENKFINPNHTGLIDVKSNVKKLVKRSSDGTSGCAQTGAAVMVNRNQTAIVAISCDDRQKDGKWYYTDLFYNTNWIRDVLNDWNKPHENKQSVPNGITGAPTANDNATNPRGCGNCIFNFYISVGCKEKGNCPKGSRVMTNGPTASHNVRQVTNREFTDNWSHANQDPNRWSKQAITNDNIQQTLQPPVAKCRDNSPECLNSAGNQDVFKPQSIFRNGDIPMIVRAQNQSIINRYGQYHPAYDGLRRFGNHPWIVRKVKKNQKQALFALRNSANKKYIKGEMGNGLRRRHVSSSGKTNEQIRNRKHAKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MVU9</accession>
    <name>A0A8J2MVU9_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to ex: Protein expanded (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS9243</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5099805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5957665at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098592">
        <property type="term" value="C:cytoplasmic side of apical plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009887">
        <property type="term" value="P:animal organ morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030182">
        <property type="term" value="P:neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035332">
        <property type="term" value="P:positive regulation of hippo signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14473">
        <property type="entry name" value="FERM_B-lobe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13185">
        <property type="entry name" value="FERM_C_FRMD1_FRMD6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17101">
        <property type="entry name" value="FERM_F1_PTPN13_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019749">
        <property type="entry name" value="Band_41_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014352">
        <property type="entry name" value="FERM/acyl-CoA-bd_prot_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035963">
        <property type="entry name" value="FERM_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019748">
        <property type="entry name" value="FERM_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000299">
        <property type="entry name" value="FERM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018980">
        <property type="entry name" value="FERM_PH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041781">
        <property type="entry name" value="FRMD6-FERM_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047145">
        <property type="entry name" value="FRMD6-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13429">
        <property type="entry name" value="FERM DOMAIN (PROTEIN4.1-EZRIN-RADIXIN-MOESIN) FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13429:SF5">
        <property type="entry name" value="PROTEIN EXPANDED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09380">
        <property type="entry name" value="FERM_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00373">
        <property type="entry name" value="FERM_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00295">
        <property type="entry name" value="B41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01196">
        <property type="entry name" value="FERM_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47031">
        <property type="entry name" value="Second domain of FERM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50057">
        <property type="entry name" value="FERM_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FERM" evidence="2">
        <location>
            <begin position="48"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="405"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="455"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="488"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="517"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="571"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="706"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="742"/>
            <end position="893"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="910"/>
            <end position="953"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1143"/>
            <end position="1167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1186"/>
            <end position="1242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1285"/>
            <end position="1330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="409"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="497"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="521"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="571"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="758"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="819"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="856"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="925"/>
            <end position="934"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="935"/>
            <end position="947"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1157"/>
            <end position="1167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1220"/>
            <end position="1234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1289"/>
            <end position="1309"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5099805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="1436" mass="157296" checksum="A267D464F69964E6" modified="2022-05-25" version="1" fragment="single">MPTVTGHTNHRGISGRWAYRRRNEACSMRGSGVTAARSCLQPLVSASRYLAVHALPGDPLYFVVEAKSRVKEVYAQTCVLLGQQGMRDCELFGLAILSDGEYLFVDPENKLSKYAPKNWRSSHTYGLDSSGRPAFVLYFRVRYYIDTPLLLSDETTRHHYYLQLRDNVVRHGGGVESLHPHHPLHTPEIVSPLLVLAGLALQADMGDYSEERHRPHAGTVGYCKPTDYLPPHMCLEANVLGVLASQHRDNRGLSREEAELQYIREAVLLEAPLNAHLYRLRRTKGEVGPGRILLAICARGVTIYTEQETPRIFAWNNIGKLCFDRKKFEIRAVDHPDKLTLYSGCDDKSKLLLGLCRDTHQFSMAIAPRVTEALRREEEERKVLRDCYMYPARCKLSMTARGSRRDQRISVISSTSSNTTSGIVSDRVHSEDEPDTAPASTECLARLTENSSPIVKKKVSLTSEEPSRSSSPVAPAGDEVDGTETFTATTTRRSATNPCTEGSQCSSSCSTVVINPLTNNPVSSRPRRPSGSSSLELGYSHTAQNSAVSSESTSFPGVIYREDRCKKSNKSFADTTSASTLPDEGFTGTDIASETSGVYTMRSSGIQDERITELYSPSGDANESISNSDVCALSSVQSTTDEASVTSGFYTIHSELRSENSDVYTEDANQDQEPIYSICKGDDEELSGPPEQHLDLEDLRSRSNSILSTGSFRGDGSDPPGIGPLLSADELSDLIVGRYPPRKTISTSMDSDCDYVTMPPPPAPPPRIDSEQPTPPPYPSNLDFRDLSKSLNSSRVIPSGEREPPPPPPYNAPRVDFVPLPPRRTEPPPPPPYTSPRERIQIPPPTPPRNDAVTPREPPPPPPYPQITEAISKLYPNNLVEEPPRIPGGKNNLSGMSNLSMNLMKNMNINSLPLPAKSSGKNKASEAPPALAPKAPKPPPRIQPPTYPGDKMKPTPVHAPVAALVVGPNNYLDVHASRSGPVLLPYLGSPTPQPPPPPPPPMVHMRQPPPPPPSLATVYTSQVARSQIEQYRQQLYSDVDYVMFPLKDPAISKQEYIDVKQGSLLSGLAAYPPPPYPSFGGNKSSVVYRSTPYLPGSSFSSSTKYASNLNLSDTSSNYPVHGNLSSHYAASTSSLYSGATCSSSVGSHSLRREPSGPANTYNHNTFSRTRSDENILKCFEAPAKGKLQSLPQTKHRRLPPPPPPPPYEIQNLEKNQPLPSASSATCSSTTNTTSIAENEGSKEDGMLDIRTLREKSRNLDLPLISALCNDRYLLKQTKAFVLPKHPAESSSSPAAASSNSVTTTTASSSKNLIGLSRDTTTSSISSRNKYPVSGLSTTQIVKPPRKLSATNQGIRTAEASRREFVISSGSVVKFCHDNYSFFQQELNRSVTGHHHQFHFQQEQVPGQWTVHYPDCQAPEETLLSYHTRIFILEILS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MW12</accession>
    <name>A0A8J2MW12_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Similar to NDUFA5: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 (Macaca fascicularis)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HICCMSTLAB_LOCUS9410</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Complex I is composed of 45 different subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the complex I NDUFA5 subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5100152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MW12"/>
    <dbReference type="OrthoDB" id="286811at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022904">
        <property type="term" value="P:respiratory electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006806">
        <property type="entry name" value="NDUFA5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12653:SF0">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12653">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE 13 KD-B SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04716">
        <property type="entry name" value="ETC_C1_NDUFA5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0249">Electron transport</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAG5100152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="118" mass="13551" checksum="65967B8EB06F96E4" modified="2022-05-25" version="1">MAGNLKKTTFLKGLEVAKQPHHSLTNIYTRILRVLAKFPTTSAYRTSTEQIVKERAEMVKNTPDVETLEKKIGCGQVEELIVQAENELLLARKMAVWKPWESLAEPIPKDQWTWPPHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MWB6</accession>
    <name>A0A8J2MWB6_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similar to pol: RNA-directed DNA polymerase from mobile element jockey (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS9684</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5100611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MWB6"/>
    <dbReference type="OrthoDB" id="7697944at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19446">
        <property type="entry name" value="REVERSE TRANSCRIPTASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="159"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5100611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="482" mass="55212" checksum="7B31549CED1D66B3" modified="2022-05-25" version="1">MKHHLTELHNACRSLNFACSSNNVEFHQLRVIYQKLISDKKKNYPKKITNDFAAVTDTTKFWAVVRSVKRVTVYTPPLPIQAWNYFYANIYPSRIVPELSLFPDNESIEIEQPFTFDEVKNCLRKLKNGKAPGCNGISNEFLKNLPTNWILYIQAMFNRILDVGETPDCWSKVVLTMLHKKGDASDPNNFRRIALVNCLAKVFTQLINQRLTTWATNNKLIPEEQAGFLKGRGCQNNVFILNAALQIYLRQAGATCFGLFVDCRRAFDSIPHHLLWPKLLSIGLSKRVINIGSMIFDPPTKYLPTKYPRTKYAFTQHLRVRSNGDFSNPVEVTTRVLQGETLSPLLFILLISDIVSYFRNKGLTELQLNNLRELLMLLYADDLVILVRRQIDVSKALSTLEEYCSRNGLEVNTGKTKVVPFCKSGFRKNFPKTFQYKDSPVEVVDSYVYLGIMFMTTMSGRQAALEAAKKKPVLPPVLPWEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MWN5</accession>
    <name>A0A8J2MWN5_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Proteasome subunit alpha type</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HICCMSTLAB_LOCUS9957</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="2">Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex).</text>
    </comment>
    <comment type="function">
        <text evidence="1">The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is a barrel-shaped complex made of 28 subunits that are arranged in four stacked rings. The two outer rings are each formed by seven alpha subunits, and the two inner rings are formed by seven beta subunits. The proteolytic activity is exerted by three beta-subunits PSMB5, PSMB6 and PSMB7. Interacts with ALKBH4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10 11">Belongs to the peptidase T1A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5100884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MWN5"/>
    <dbReference type="OrthoDB" id="5835702at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019773">
        <property type="term" value="C:proteasome core complex, alpha-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03754">
        <property type="entry name" value="proteasome_alpha_type_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000020">
        <property type="entry name" value="Proteasome subunit alpha type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050115">
        <property type="entry name" value="Proteasome_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023332">
        <property type="entry name" value="Proteasome_alpha-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000426">
        <property type="entry name" value="Proteasome_asu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034642">
        <property type="entry name" value="Proteasome_subunit_alpha6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11599">
        <property type="entry name" value="PROTEASOME SUBUNIT ALPHA/BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10584">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00948">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00388">
        <property type="entry name" value="PROTEASOME_ALPHA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51475">
        <property type="entry name" value="PROTEASOME_ALPHA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0007">Acetylation</keyword>
    <keyword evidence="3 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5 10 11" id="KW-0647">Proteasome</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proteasome alpha-type subunits" evidence="12">
        <location>
            <begin position="9"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00062366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS00388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAG5100884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="246" mass="27440" checksum="8005422245A51EDF" modified="2022-05-25" version="1">MARGSSAGFDRHITIFSPEGRLYQVEYAFKAINQGGLTSVAVKGVDTAVFATQRKVPDKLLDPSSITHIFQLTEHIGCVMTGMIADSKSQVQRARYEAANFKYKFGYEIPVDTLCRRVADIGQVYTQNAEMRPLGCSMMLIAYDKEKGPCIYKADPAGYFCGYRAISVGARQTEANSYLEKKLKKKQNYNHDETIQLAITCLSTVLSVDFKPSEIEVGVVSKDNPKFRVLTEQEIDKHLTAIAEKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MY83</accession>
    <name>A0A8J2MY83_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Similar to Fit1: Unc-112-related protein (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HICCMSTLAB_LOCUS12580</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the kindlin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5107089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MY83"/>
    <dbReference type="OrthoDB" id="10057618at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030055">
        <property type="term" value="C:cell-substrate junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005178">
        <property type="term" value="F:integrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048513">
        <property type="term" value="P:animal organ development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007160">
        <property type="term" value="P:cell-matrix adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007229">
        <property type="term" value="P:integrin-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048731">
        <property type="term" value="P:system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd14473">
        <property type="entry name" value="FERM_B-lobe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13205">
        <property type="entry name" value="FERM_C_fermitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17096">
        <property type="entry name" value="FERM_F1_kindlins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01237">
        <property type="entry name" value="PH_fermitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000037">
        <property type="entry name" value="Fermitin family homolog 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019749">
        <property type="entry name" value="Band_41_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014352">
        <property type="entry name" value="FERM/acyl-CoA-bd_prot_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035963">
        <property type="entry name" value="FERM_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019748">
        <property type="entry name" value="FERM_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037843">
        <property type="entry name" value="Kindlin/fermitin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040790">
        <property type="entry name" value="Kindlin_2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037837">
        <property type="entry name" value="PH_Kindlin/fermitin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16160">
        <property type="entry name" value="FERMITIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16160:SF13">
        <property type="entry name" value="FERMITIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00373">
        <property type="entry name" value="FERM_M"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18124">
        <property type="entry name" value="Kindlin_2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00295">
        <property type="entry name" value="B41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47031">
        <property type="entry name" value="Second domain of FERM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="4">
        <location>
            <begin position="358"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="153"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="153"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="173"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAG5107089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="664" mass="75710" checksum="9E5B572266D0D50F" modified="2022-05-25" version="1">MDWSDHALWWPKRNHWLTRTRSTLDQYGVAADALLHFTPMHKTLRVQLPDMRYLDCRVDFSVKTFNTVINLCKELGIRHPEELSFCKPLEPNHLKYNLKDLPAKKKIENQKNGHWNVPADTNTFIPVSQSPQGSNGSLDQSSPFMCAPVTPNNRNHSTPISSPVSHTGTWKRNNNSSGFGSTGSFNANNSTMSLEALNGGMTESLAQSPSAASPDVHAKLIKPKNLVERARMNVAWLDSSLSIMEQGIREFDILRLRFKFYSFYDLNPKTDAVRINMIYEQAKWQLLAEEIDCTEEEMLMFAALQVQVNLQASMPQPSYESNGSSSLIEDDIDAALTDLQVSLEGSSISNGTSDVTQVPELCDYLRFFKPKRFTLKAFKRYWFTCRDLQLRLYKTREESHSSEAPAYIINLRGCEVTPDVHLSQGRYGIRLEVPSADGMTEMWIRCDTEQQYAKWMAACRLAAKGRSLADSSYESEVNSISAFLQLQRPAPAPAINPSSLNITPEDYVAPRYSKKLRGKLVQRILEAHANVKDLPLVDAKLNYIKAWQSLPEYGISLFVVRFTGKNKDELLGIANNRLMRMDLHSGDHLKTWRYNTMKAWNVNWEVKHMMVQFEEENIIFECQSADCKVVHEFIGGYIFLSMRSKEANQTLNEEMFHKLTGGWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MYD1</accession>
    <name>A0A8J2MYD1_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Riboflavin transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HICCMSTLAB_LOCUS12763</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Plasma membrane transporter mediating the uptake by cells of the water soluble vitamin B2/riboflavin that plays a key role in biochemical oxidation-reduction reactions of the carbohydrate, lipid, and amino acid metabolism.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>riboflavin(in) = riboflavin(out)</text>
            <dbReference type="Rhea" id="RHEA:35015"/>
            <dbReference type="ChEBI" id="CHEBI:57986"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 9">Cell membrane</location>
            <topology evidence="2 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the riboflavin transporter family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5107477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MYD1"/>
    <dbReference type="OrthoDB" id="9995836at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032217">
        <property type="term" value="F:riboflavin transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009357">
        <property type="entry name" value="Riboflavin_transptr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12929:SF10">
        <property type="entry name" value="RIBOFLAVIN TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12929">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06237">
        <property type="entry name" value="SLC52_ribofla_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="50"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="82"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="114"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="145"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="202"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="264"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="297"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="332"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="370"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="402"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU368035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAG5107477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="442" mass="48286" checksum="2C54290C90E089AB" modified="2022-05-25" version="1">MSNLSQKLSNRKLIVDGLAVLFGIGAWIGINGIYVQLPLFVLSAPEQWELPTYMVMLVQLANLGPILYTLYAKYSSWSRDHYIIYGLIGTGTIAIYTMSLTYKNTSTILGNDHSTALLGLMFLTAVVGCTSSVLFIPYMRNYREIYLVSYLVGEGLSGFLPSVLALIQGVGGNSECKYVIKPGNVNATLEEVHPEPRFSTEVFFVILGTILLLSFLSFVGLNKLPIALGERSKPPGCTETLPTETNAPPSYKTTAGWCMSKQMYIYLLSIMGVVCFLDHSILPSIQSYACLPYGNVAYHLTVTLSSMASPLSMCLGFIWTPPKSDDFRHHQNLRLFTILTGIIVVLSSFVMYLAVESPTPPLQGMWTGEMLVVVLWIVLKGLLGFVKMGITTLFSGDPGRGLYYTGVATQVGSLIGAAIIFTLIKYGGIFQTYSPCAALAAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MYN9</accession>
    <name>A0A8J2MYN9_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Similar to cki-1: Cyclin-dependent kinase inhibitor 1 (Caenorhabditis elegans)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HICCMSTLAB_LOCUS11799</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CDI family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5104031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MYN9"/>
    <dbReference type="OrthoDB" id="6373236at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004861">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051726">
        <property type="term" value="P:regulation of cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.365.10">
        <property type="entry name" value="p27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003175">
        <property type="entry name" value="CDI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044898">
        <property type="entry name" value="CDI_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10265">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE INHIBITOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10265:SF45">
        <property type="entry name" value="DACAPO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02234">
        <property type="entry name" value="CDI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0649">Protein kinase inhibitor</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin-dependent kinase inhibitor" evidence="7">
        <location>
            <begin position="44"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="109"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="115"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="145"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="216"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG5104031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="233" mass="25711" checksum="57111287E9AD6824" modified="2022-05-25" version="1">MSARVMNPAMMTESRKLGGAVGGGGSGGRVVPTRAELAKVRRDLFGPVDHEAARAFVERELKAQSVLDAERWGFDFSLGLPRNTSARYDWEVVSNEEVVPEPYALRGMPYLRKNAPSTPRKTNERSVSSANRRSTSLSPMNMDSGRPKAERTPPQEPRVPEIGEPEDEFRGECAKKSCVIPEPTTPVLPTSARKQSSITDFMKTRKRTSNSSTKKSSIEPPEKLPRNAGQIRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MYR1</accession>
    <name>A0A8J2MYR1_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Similar to EAG_05630: Diuretic hormone 44 (Camponotus floridanus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HICCMSTLAB_LOCUS13158</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5108279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MYR1"/>
    <dbReference type="OrthoDB" id="6418774at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005179">
        <property type="term" value="F:hormone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000187">
        <property type="entry name" value="CRF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00473">
        <property type="entry name" value="CRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00039">
        <property type="entry name" value="CRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0372">Hormone</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035208469" evidence="4">
        <location>
            <begin position="19"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="Corticotropin-releasing factor" evidence="5">
        <location>
            <begin position="84"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAG5108279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="213" mass="24782" checksum="80B43AB7B9020CF0" modified="2022-05-25" version="1">MFLMNLLTVTTLITLSKSRPLSYYLTHQRRDAPTDGAGGGDYDDGVFVPYIIDEKGFSANEFYWPQDENLKVNDSVSGIDRGKRIHSLSVTNSLDVLRDRVLLELARRKAQQEKIQIDANRHYLDNIGKRSNQYIKMDLPQIFEPKNIKIPQIFDHQLIGDQSEFNNYYMAKNPLPLDSTLTLDWYNNLNDVSQYNLNDQIRKIKKNNKIRLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MZ45</accession>
    <name>A0A8J2MZ45_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Neurotrypsin</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Serine protease 12</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">HICCMSTLAB_LOCUS12344</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Plays a role in neuronal plasticity and the proteolytic action may subserve structural reorganizations associated with learning and memory operations.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5106607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MZ45"/>
    <dbReference type="OrthoDB" id="6020543at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007599">
        <property type="term" value="P:hemostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00112">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd01099">
        <property type="entry name" value="PAN_AP_HGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.250.10:FF:000007">
        <property type="entry name" value="Soluble scavenger receptor cysteine-rich domain-containing protein SSC5D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000068">
        <property type="entry name" value="transmembrane protease serine 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.4.10">
        <property type="entry name" value="Hepatocyte Growth Factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.400.10">
        <property type="entry name" value="Low-density Lipoprotein Receptor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.250.10">
        <property type="entry name" value="SRCR-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000001">
        <property type="entry name" value="Kringle"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013806">
        <property type="entry name" value="Kringle-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036055">
        <property type="entry name" value="LDL_receptor-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023415">
        <property type="entry name" value="LDLR_class-A_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002172">
        <property type="entry name" value="LDrepeatLR_classA_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003609">
        <property type="entry name" value="Pan_app"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001190">
        <property type="entry name" value="SRCR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036772">
        <property type="entry name" value="SRCR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033116">
        <property type="entry name" value="TRYPSIN_SER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24252">
        <property type="entry name" value="ACROSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24252:SF7">
        <property type="entry name" value="HYALIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00057">
        <property type="entry name" value="Ldl_recept_a"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00024">
        <property type="entry name" value="PAN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00530">
        <property type="entry name" value="SRCR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00258">
        <property type="entry name" value="SPERACTRCPTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00130">
        <property type="entry name" value="KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00192">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00473">
        <property type="entry name" value="PAN_AP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00202">
        <property type="entry name" value="SR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57414">
        <property type="entry name" value="Hairpin loop containing domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57440">
        <property type="entry name" value="Kringle-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57424">
        <property type="entry name" value="LDL receptor-like module"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56487">
        <property type="entry name" value="SRCR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01209">
        <property type="entry name" value="LDLRA_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50068">
        <property type="entry name" value="LDLRA_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50948">
        <property type="entry name" value="PAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50287">
        <property type="entry name" value="SRCR_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00135">
        <property type="entry name" value="TRYPSIN_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9 14" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0356">Hemostasis</keyword>
    <keyword evidence="7 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 15" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-0675">Receptor</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="8 15" id="KW-0720">Serine protease</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Apple" evidence="18">
        <location>
            <begin position="94"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="17">
        <location>
            <begin position="221"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="17">
        <location>
            <begin position="373"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="16">
        <location>
            <begin position="445"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="185"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="197"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="293"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00030576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU363034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="CAG5106607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="650" mass="71959" checksum="A4EC84681E73E1ED" modified="2022-05-25" version="1">MKKKYPCYNNPDSTCLSDYFFWDIEDCAASMKGHAYICKRPYDDISCVYGKGHQYLGKASVAASGKPCLPWNHTAVAYPLLVNDCTNGRDELRCSEHLEFFSKTQGHRLTGYEVEKWLNTPAKTCALRCKEAKFTCRSFSHKTSENLCLLSDNNVGSTGALEATSGFDYYEMIDLSVDCTGLFVCNNKKCINQTQVCDGKNDCKDRSDENSCDPAKLDYEIRLSGSENEYEGRVEVKIMGVWGQVCDDNFGMLDAEVICRELGFELGALELRLGGFFGNMDPSTRFMVDQLTCRGNETSLRECDFDGWGVHNCSPEETAGVVCKTAVETCPEGNWKCDTSPVCIPTPFICDEVVDCPDSSDESPAHCDAPFEIRLANGSSPSEGRVEIRHHGVWGTVCDDDFTHAAAKDESNRVVTEVNINDILPSNCGKRAEDFHNEEEIFAKVVRGSVAPKDSYPWQASIRVRGHSRSNHWCGAVVISPLHVLTAAHCLEGYNKGTYFVRAGDYNTEITEGTEADANIEDYYIHEEFRKGHRMNNDIALVLLKGRGIPLGEHIMPICLPPRNVEYPDGLNCTISGFGSIETGKSAHSRDLRFGWIPLIDQNICRADYVYGEGAISDGMMCAGYLNEGVDACDGDSGGPLACHHNGKFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2N0G7</accession>
    <name>A0A8J2N0G7_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">GMP synthase (glutamine-hydrolyzing)</fullName>
            <ecNumber evidence="3">6.3.5.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Glutamine amidotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HICCMSTLAB_LOCUS13570</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="pathway">
        <text evidence="1">Purine metabolism; GMP biosynthesis; GMP from XMP (L-Gln route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.2" evidence="3"/>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5108934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2N0G7"/>
    <dbReference type="OrthoDB" id="1724632at2759"/>
    <dbReference type="UniPathway" id="UPA00189">
        <property type="reaction ID" value="UER00296"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003921">
        <property type="term" value="F:GMP synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01742">
        <property type="entry name" value="GATase1_GMP_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01997">
        <property type="entry name" value="GMP_synthase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.10:FF:000014">
        <property type="entry name" value="Burgundy, isoform B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.10:FF:000013">
        <property type="entry name" value="GMP synthase (Glutamine-hydrolyzing)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000044">
        <property type="entry name" value="GMP synthase [glutamine-hydrolyzing]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.880:FF:000013">
        <property type="entry name" value="GMP synthase [glutamine-hydrolyzing]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001674">
        <property type="entry name" value="GMP_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004739">
        <property type="entry name" value="GMP_synth_GATase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025777">
        <property type="entry name" value="GMPS_ATP_PPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00888">
        <property type="entry name" value="guaA_Nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11922:SF2">
        <property type="entry name" value="GMP SYNTHASE [GLUTAMINE-HYDROLYZING]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11922">
        <property type="entry name" value="GMP SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00958">
        <property type="entry name" value="GMP_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00097">
        <property type="entry name" value="ANTSNTHASEII"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00096">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54810">
        <property type="entry name" value="GMP synthetase C-terminal dimerisation domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51273">
        <property type="entry name" value="GATASE_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51553">
        <property type="entry name" value="GMPS_ATP_PPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="6 11" id="KW-0332">GMP biosynthesis</keyword>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 11" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GMPS ATP-PPase" evidence="12">
        <location>
            <begin position="187"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="215"/>
            <end position="221"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAG5108934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="688" mass="75897" checksum="CB1933D8318B87CD" modified="2022-05-25" version="1">MDKTTDGLHQERNNGAEDVTMTLVNSDERVAILDAGAQYGKVIDRKVRELNVQCEILPLDTPAFTLKEKGYKAIIISGGPSSVYAEDAPRYDGDIFRIGIPVLGICYGMQMMNKEFGGTVQRKEGREDGQFSIEVDSKCLLFKGLEKDQLVLLTHGDSIDRVADCFRATAKSTNFIVGISSDKMNLYGVQFHPEVDLTTNGKQILHNFLFGLLVSGGVDSTVCAALLHKALSKEQVIPLHINNGFMRKGETPFVEQSLAELGVKLRVINATHNFMEGTTSVPLDHVSPTNIANNKGIGVTAIGPRIRITKMLCQTTSPEEKRKIIGDVFVRVANDAMTEMGLKPEQVFLGQGTLRPDLIESASALASGKADAIKTHHNDSELVRALRSQGRVVEPLKDFHKDEVRQIGCDLGLPAPLVQRHPFPGPGLAIRILCADEPYMDKDFSETQVIVKIMAEYEQMLQKKHALLNRVESATSESERQHLRRVSSENHIAATLLPIRSVGVQGDRRSYSYVVGLSCQGPEPDKELPLENVIWEDLLFLARLIPRVCHNVNRICYIFGPIVQHPITDITPTHLTSNVISTLRQADHLANQVLVSNNCMNAISQMPVVLIPVHFDRDAASRVPSCQRSVVLRPFCSSDFMTGTPAIPGNQLPIHVIKKMIAEISTVPGISRVLYDLSSKPPGTTEWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2N0V9</accession>
    <name>A0A8J2N0V9_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS14027</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001349">
        <property type="protein sequence ID" value="CAG5109391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2N0V9"/>
    <dbReference type="OrthoDB" id="7711210at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5109391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="166" mass="19075" checksum="AE671E18810FE663" modified="2022-05-25" version="1">MSEEASSVGKFDHDNGQQIKDEELFKKFLERYRKVFQFEQNHPGKEISLSISGERVLFHVETREVPYQADKSNMNEDEWRAAIKWIEKQEGDGPWVVSPGDDDQKSVSQEDEETLLRDAIERGDEAERERCEKKRCDKESTLLNKADLSQGVAKKNEIEALPGTAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2E0V1</accession>
    <name>A0A8J2E0V1_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS427</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001114">
        <property type="protein sequence ID" value="CAG5073484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2E0V1"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5073484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="123" mass="13458" checksum="AD4904764E1F066E" modified="2022-05-25" version="1">MSAFVVSSLTSRISIVSCSPLHITLASSLRMSAMVFCRASPLSALFLESVISMSTVLVLWIFSTVVRTCSSGTDCLIQRRISAYFSFSAERMIRASGLMCIAHTGIYIVVNERHGLVESRNQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2E292</accession>
    <name>A0A8J2E292_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Odorant binding protein 139.10651</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS1243</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001116">
        <property type="protein sequence ID" value="CAG5075069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2E292"/>
    <dbReference type="OrthoDB" id="10356202at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005549">
        <property type="term" value="F:odorant binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.20">
        <property type="entry name" value="Pheromone/general odorant binding protein domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006170">
        <property type="entry name" value="PBP/GOBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036728">
        <property type="entry name" value="PBP_GOBP_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01395">
        <property type="entry name" value="PBP_GOBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47565">
        <property type="entry name" value="Insect pheromone/odorant-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035158984" evidence="1">
        <location>
            <begin position="21"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5075069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="193" mass="22033" checksum="9B4A87241A28508F" modified="2022-05-25" version="1">MATLYSTVLACFLLAAVTSAEPVNYNDILLATYQECKYLNDSSNDKQQNEYYRSLLPEEKYIVTNYGISEYLACFIKKLNLFTLEDYKVYKDGVQYCLALIDSNSTITDPDEEQRLGNICILKTLKTIKSDNSIDAEVLKKYLTVFVAVTDELFESNQALEYFNNCVNEKGSDAEDTISKFLECIDRNRNSKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2E2T5</accession>
    <name>A0A8J2E2T5_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS1542</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001116">
        <property type="protein sequence ID" value="CAG5075388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2E2T5"/>
    <dbReference type="OrthoDB" id="7604615at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5075388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="76" mass="8569" checksum="47F705E4E980D7AB" modified="2022-05-25" version="1">MENYSLYFQGYCYIWSESEGRKGSQGISTCLDKFINEEVPSGIETLNFFVDNCAGHNKNSIVVAMLGISFHEHPTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2E8Q1</accession>
    <name>A0A8J2E8Q1_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Similar to ZNF808: Zinc finger protein 808 (Homo sapiens)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HICCMSTLAB_LOCUS397</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001114">
        <property type="protein sequence ID" value="CAG5073454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2E8Q1"/>
    <dbReference type="OrthoDB" id="3437960at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012934">
        <property type="entry name" value="Znf_AD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24409:SF295">
        <property type="entry name" value="AZ2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24409">
        <property type="entry name" value="ZINC FINGER PROTEIN 142"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07776">
        <property type="entry name" value="zf-AD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12874">
        <property type="entry name" value="zf-met"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00868">
        <property type="entry name" value="zf-AD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51915">
        <property type="entry name" value="ZAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="ZAD" evidence="8">
        <location>
            <begin position="12"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="573"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="613"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="653"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="14"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="17"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="61"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAG5073454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="799" mass="92249" checksum="238CE1C3A1A6F72E" modified="2022-05-25" version="1">MSENCIKNCMIDKCRICLSNSNSMIDMFRPEIFIKIKEFAASISTVIDNDNDLPKNICHICLYKLDMWDDFKQQLINSNQFLLNLSDSHELSILEKNSVNNINNLTNDNDLMQLANESSQINSQPLKALNSEVASNKTNLNMLQSQFSLKTSKNETENSSEGKQTTELLIKTRYSGIRRTNEQRMASTQRWVARKRALLAATGENDSDTDSINSDATLKLSSLKKHRKSFNFSTNENHQFEPQSMQSELVMGDAMFIITSSLFLSELSNVNQLSNVLKLPSNHEGNNIVTHKQQNIDIMNALQLCRIESSNKYLMEDGKFVERCLNIEIEGTEFEKLQNLQFKLASFIDKDLKKKLINEKDCSEDMDSENIKCREPFQTLEQQLKVIVEKSVKKNLNKYQVMQCKTINKFHHKKTFSTAFIKAAMKSKVFQPRVFLDRLDLNLINIENDRNSHKLPKHLTNLNCYKNQVHNVDERNNYCNGNDIKILKKLKEKKESIDVNNDGLNDKRHVCRAHSGSFDRQLDVHRNFSIHKEQVLSEKIVKKIMRCKECDESVEADLVETHICKSLLSKYHHKCNKCDIIFCTDSLLLNHKKIHEKDQKISKVFTTDLEKLYSCFICNKKFTDDEILKKHLQNYCDDANKEHGNMSTSMKMFQCAICGHTLSTEDKLEAHVEQHLLDDADNNSNLVNIIQANSIKESPGIQSDVKRSYLHSNNKFDTNVELALNIQTHDTKDKIIESLQDDFQMQNESRMCTICDLNFNNEQELLDHLNVHNNASCVCMLCDQPFLTLVELQKHVNSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2EAI1</accession>
    <name>A0A8J2EAI1_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to Aldh1a3: Aldehyde dehydrogenase family 1 member A3 (Mus musculus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS7</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030000061">
        <property type="protein sequence ID" value="CAG5070418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2EAI1"/>
    <dbReference type="OrthoDB" id="310895at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000050">
        <property type="entry name" value="Aldehyde dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11699">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5070418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="276" mass="29552" checksum="8ECC9CADFD4BA3E2" modified="2022-05-25" version="1" fragment="single">ADVDKAVAAAKKAFARGSEWWSLQPAQRSALLNKLADLVERHVQEIASIMTLENGKPFAHAVGETQMAADTSRYKAGWCDKIQGQTIPTDDGSFVMTRKEPVGVVGQITSWNFPVLLYAIKLGPALAAECPVVLKPAEQTPLCNLYLAALTKEAGFPPGVVNVIPGFGPTAGAALAEHPDVAKISFIGSVEVGKLIMKASGNSNLKRVTFDLSGKSSLVIFDDVNVDEAAKIAHEAIFANSGQVCIAASRTYVHSKIYSEFVKKSRELAWNRKVGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2EBS5</accession>
    <name>A0A8J2EBS5_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HICCMSTLAB_LOCUS2061</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the clarin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001116">
        <property type="protein sequence ID" value="CAG5076080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2EBS5"/>
    <dbReference type="OrthoDB" id="10012538at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007605">
        <property type="term" value="P:sensory perception of sound"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026748">
        <property type="entry name" value="Clarin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31548">
        <property type="entry name" value="CLARIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31548:SF1">
        <property type="entry name" value="LD47387P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="163"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="223"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="254"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="304"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAG5076080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="352" mass="39156" checksum="DC9446CD17F80B64" modified="2022-05-25" version="1" fragment="single">VEGSRKSIISHYGLYQNSYSCSNAPGSIYGYPTTTTTTTPTASYLPAYPHFQSQFQLNEDYRPIYFYVAQPYTIPYTFAKRPKSNNNNNHTLSIGRSTRSRSRVKFSKKLSNAEFSQKVKQGEFSKSLNQVQFVDSTVKTSPKELPRKPVDPAMTSMFRRGTIFATFFLSLIGGGLVCAALVTQHWVEAKAWRTPNPHESAGKIHFGLLNGKKELNVAYGWRTYHITAAGLSALIAVLNTATTPRVKLLSVPGVYIINSLTLILCITSVSTWLAQFYTKLQNNVLPKEDVDNMWTSEGSAELGYSFWMVVSAGVVHLISIALVGWGSGRVKEDRIEHIPALEEKTAAAIMLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2ECE9</accession>
    <name>A0A8J2ECE9_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">protein-tyrosine-phosphatase</fullName>
            <ecNumber evidence="1">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HICCMSTLAB_LOCUS1005</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="1"/>
    <dbReference type="EMBL" id="CAJNRD030001114">
        <property type="protein sequence ID" value="CAG5074294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="8609993at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:001177">
        <property type="entry name" value="Receptor-type tyrosine-protein phosphatase beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000823">
        <property type="entry name" value="Tyrosine-protein phosphatase 10D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041201">
        <property type="entry name" value="PTPRJ_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050713">
        <property type="entry name" value="RTP_Phos/Ushers"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46957">
        <property type="entry name" value="CYTOKINE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46957:SF3">
        <property type="entry name" value="CYTOKINE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18861">
        <property type="entry name" value="PTP_tm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1265"/>
            <end position="1287"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="3">
        <location>
            <begin position="158"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="3">
        <location>
            <begin position="254"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="3">
        <location>
            <begin position="476"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="3">
        <location>
            <begin position="656"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="3">
        <location>
            <begin position="935"/>
            <end position="1025"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="3">
        <location>
            <begin position="1026"/>
            <end position="1125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG5074294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="1335" mass="150246" checksum="6E262E47DA8E3AB4" modified="2022-05-25" version="1">MTTSRFTDPKNFSNCDLKTSPSLSRPSHYSSTGQYLLASLGQELSIEYPHDHLLLEVLSRNSKPNQTLAQVWRSDSADLAIEIPGNLTQQGTWYRLDYSPPVGEPPPNTKIPAVDIGDVIKFQKGLAGTKYEFWLYYNNGSWNDWLTWTASITTAPDPPSNLTVLVRNGKTAVVYWSPPAEGNYSGFRMRVQSFNDLANPPSTTRTSVISSDAIPYTLRDLTPGATYSLQLFTVLEAKESVAYTSKNFTTKPNTPGKFIVWFRNETTLLVLWQPPYPAGIYTHYKVSIEPPDAVESVFYVEKEGEPPGPAQAAFKDLVPGRAYNISVQTVSEDETSAPTTAQYRTVPLRPLNVTFDRSSITSSSFRVFWSPPNGSSEFDKYQVSLGNNRRVPTVTRNRYEEDSTSWEFHDLEAGKTYQNPSKILFFGNIFKIVPSELIQDLVPRTTLTLKFLLQVVVKTVSGKVTSWPASGDITLKPLPVRDLRASIDERMLEVSWRPDNTSIQDSYRLEYHEVDTASSGDSNTLTIEKTRVVLEALLPGRNYTIIVAAISNKVESNETVIYQVTRPSSPIIEDLKSIERGLNISWKSDVNSRQEKFEITHTRNDTGESATTLTTESHIILEDLYPGAGYEVKVFAISHGLKSEPHDYFQAVLPHPPQHLRIDRVDLGNKSVLVRWSPPINSLFSEYSVKFRTDDSTWTRLPSVRRTEAEILELTPGERYVIQVNTVSFGVESLYPLQVNHTVAPNPVTNITPIVDSTNVTLEFPRPQGRIEFFTFTWSATSDPGDDLGVRSKNISGLEEDPDKFVIGNLIPGVEYVFSVATTSHDLVSELTNVTARTMPLIQSEVVIVVDQDVTDALAMRYTRTPIQISRFDLYRFRISDDLNTTTEKQVDDPDTKVTFSNLIPGRLYNVTFWTVSQGISSRPLFRQDRLYPLPISALQEVEVNATWISLSWDIPAGEFDAFEMQFINGDKLVQNITSTNLLVIQDLRPWRNYTFTLVVCSGYYSNLHLRRSHPVSASFTTSESFPGRVEKFDPTDIQPSDISFQWFLSPTEFNGVITKFTITYQLDGSKHTGAKDFKANENQGMIKGLIPGKTYAFSIQAKTKVGYGPENVWRQKMPILAPPKPPTQVVPTEVCRTSSTIQIRFRKNYFSEQHGSVIAYTIIVAEDDSKNASGLEMPSWKDVQAYSIWPPYQVMEPYYPFKNSSVEDFTIGTENCDGKVIGYCNGPLKSGSTYRVKVRAFTAPDKFTDTSYSFAIQTDKDNTAIIVGVTVPIILLLTLLGIGLFVRRHRNQLRKIAEPRAGGPSDNLSLPDSVIETRYFFQFRFFKIAPESCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2ECF5</accession>
    <name>A0A8J2ECF5_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Similar to Ncor1: Nuclear receptor corepressor 1 (Mus musculus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HICCMSTLAB_LOCUS2408</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001117">
        <property type="protein sequence ID" value="CAG5077247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2ECF5"/>
    <dbReference type="OrthoDB" id="10258692at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017930">
        <property type="entry name" value="Myb_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017884">
        <property type="entry name" value="SANT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00249">
        <property type="entry name" value="Myb_DNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51294">
        <property type="entry name" value="HTH_MYB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51293">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH myb-type" evidence="5">
        <location>
            <begin position="180"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="3">
        <location>
            <begin position="180"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="SANT" evidence="4">
        <location>
            <begin position="183"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="253"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="326"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="438"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="555"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="780"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="857"/>
            <end position="879"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="900"/>
            <end position="926"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="984"/>
            <end position="1035"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1074"/>
            <end position="1137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1145"/>
            <end position="1164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1170"/>
            <end position="1280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="278"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="326"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="353"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="370"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="389"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="399"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="447"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="780"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="909"/>
            <end position="919"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="984"/>
            <end position="993"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1019"/>
            <end position="1035"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1074"/>
            <end position="1094"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1098"/>
            <end position="1116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1170"/>
            <end position="1183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1271"/>
            <end position="1280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAG5077247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="1280" mass="139922" checksum="EFF36C88EC461818" modified="2022-05-25" version="1">MSWRKRCNQAGRDRDLNAGSECKSGLRSTPPATLKYSREGGRQLGPHTCVICKSMVEGGNQSRALSRSHASQYGLREDQIQPGSRVCNTCRCKAVRGRYTACPLPGCPNVNNSSAKTRVKRLRALPSKWMELPAEVWEPVVQEFQIPNNATKCCSACFNRISRRLAPHLTAGADASEDSSESSTRQQWTEEELKLLKRALKEHATNWQKVAEMIPGKSNHQCKTYYLTYRKKLGLDQIVTEYYEARGEDFRRPFLTDEEESGSSTSSCDELAVHDSSDTASAGSPANIISSSTAPTLVASSSSTKQKMMFPENTADIRISLVPPVAAASSSQQPTTGGGPGQPAVNSREDYDSSATETADEGQGNTELESTGGVTVTQSSTANTNTLIQSQQPQQTQQPQPPPPPPPPGHSPPTTASSTNPLTVKDLMLGVIEMQLKRNNVSPAGPPGSTSSSGSSSMSNILKADHRNDITFVREFKPASSMPSTAISNRDSNLATLSVVSCHRSAPSPQQIGQMQATITPCPPPVQSSQPQSSDMLPKEGLVVMQVQQALRETEGTLDLSIKKPRQQPPPPQDYNHTHPAHKPPVSLYRPEPSPGYYHHPHSEQGRGAKSPLIYASSPRPQAPITPKMNKVPATPPHPKLSPKLSTIGPAHKGGSITHGTPVPSARYEGLLRQMTPPGNSGSSGSSGGNSAPKESGSITQGTPVHPFTVSLDKRNPMYDYHRPVRHSPATTNVPCQTQGVVVTHSNQYNSYPPRPLPSYTMEPQLSSRQIIMNDYITSQQMHQRGRTSSSETPGKSEPPPSSGLYYTSTPPPPQSHTQPRQGVIQRHNPQKQIHYQPPPAGLEAFSSLVDVAVQQPSLPVPHPHAPHSSSSSKSKQYVDNNRAYREQEIQLQEQHRFAMQHAERIHHQQQQQQQQQQQQRERERDLAHIREKEEQQQQQQRLHREKEMQQMEQRISEGSSTLTAASLIDAIITHQINQSFKTTGGATATINPPTRPGDRLFQSFHRDNPPEPNGVAHSPAGEAAAGNSAAQNEPTQDVKAITIGDHVDHIVTKEYAPPHGSYRSYPGYTISDDQWKRRENEPESAKSSDERQIIRVSQSQQQSSTPQQSQQPPSSGKQFHPVEPVSPPEATTNHYTARRYYESTTATTTSGTPSKPHLSPLDYVKNKIVEVMRTSEDDKPGSDRSSGNGNVDKDDKPAESPSTGEMVIDESPSQPTQPPPPTSTTFYPYNALGVQVHTGMPQPPPPSATSSANVSKSEHMQGEFVPLMSDKYEPLSDED</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2EDZ9</accession>
    <name>A0A8J2EDZ9_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Similar to ric8a: Synembryn-A (Danio rerio)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HICCMSTLAB_LOCUS2322</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cell cortex</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the synembryn family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001117">
        <property type="protein sequence ID" value="CAG5076919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2EDZ9"/>
    <dbReference type="OrthoDB" id="5585685at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001965">
        <property type="term" value="F:G-protein alpha-subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007186">
        <property type="term" value="P:G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008376">
        <property type="entry name" value="Chaperone_Ric-8_A/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019318">
        <property type="entry name" value="Gua_nucleotide_exch_fac_Ric8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12425">
        <property type="entry name" value="SYNEMBRYN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12425:SF5">
        <property type="entry name" value="SYNEMBRYN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10165">
        <property type="entry name" value="Ric8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01802">
        <property type="entry name" value="SYNEMBRYN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAG5076919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="456" mass="51272" checksum="9D861D2DD2018FF4" modified="2022-05-25" version="1">MANSHSVIKMIRDKKDLDIIITDERLNIILLKADLAAPVPPPYTETTLEAVKLLCNLIYNSPSVQIQIAKTDCLKNLVTRISNYDPTVTNNIMLFDMRILFLITALNIPSRNICKNEYNGDKLLIDCLNNLSNRLSSSKEIVEVICELLKALYNIYIDAEETTKEQSETNKRLVGILYRLLTSEDVKKLDSKELQSGIADLLIVIPYTSFDPLVPRISPENKSSEVFEDLDMSAIWELVKYLDACLNSRENLVKNTLPAVSALLKLARSNRCIRKYARLKVLPPLKDVMKRPEEGTTLRAKLCKLLTFPIVELRVAISEFLFVLCKKNVGRMIKYTGFGNAAGMLANKGLLGGNQPETNYSSESGESDTEEYTKYKENINPVTGCYENPKPSPLEGMTEEQKEYEAMKLVNLVNKLSSDGIIKPCTVGEDGKPKPIEHVFELQKGLNLPKNDSDED</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2EE52</accession>
    <name>A0A8J2EE52_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Similar to phtf: Protein phtf (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HICCMSTLAB_LOCUS2412</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001117">
        <property type="protein sequence ID" value="CAG5077263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2EE52"/>
    <dbReference type="OrthoDB" id="10066656at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039775">
        <property type="entry name" value="PHTF1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021980">
        <property type="entry name" value="PHTF1/2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12680:SF6">
        <property type="entry name" value="PROTEIN PHTF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12680">
        <property type="entry name" value="PUTATIVE HOMEODOMAIN TRANSCRIPTION FACTOR PHTF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12129">
        <property type="entry name" value="PHTF1-2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="59"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="88"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="415"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="482"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="564"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="597"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="domain" description="PHTF1/2 N-terminal" evidence="8">
        <location>
            <begin position="1"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="121"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="239"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="127"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="258"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAG5077263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="668" mass="75607" checksum="3F2A9D81B7CC8F81" modified="2022-05-25" version="1">MRTAKLKTEFIDVDLVRGSSFPKAKPKHGLITVTWLAVKRLILLPFYKSWWIQQTSSRIFLLFILLYSLQIFNIIIFIAGANFNDSDIVSLTEVLMPVAMMFLLCTVHSQIVSTNSGPTISTGINRSRARRSRHERTRPGKLRPRNLQRGHRIGSDINKTSQETVCCDKSNAKNYSSVSPSVRFAKKVCIDPSTPRREIPSSSKELDKSRVITSTPVQESVLNRSRLAVTVANVNLNVDGVHQDDDGFESLNGNVSSDNDRASLRPQVPKDEEIKPESKDINSSKPVESVKQFESEEEGECEETGTNQLTEVTTSATEWMGVTTNSDECSYSSDLDESQLHSDSNYSYGEFVEHPFSWEFELPPSILLSSSCMTSDRVTCTLWTRREIKKAELSVLDISSAIIARAESMPESLDYFYGGLVLSMILAVIPALRRLSDHFGSDTGNSTGIVVDLALIDFNIYVDFLKEIIDVSFGSTLWERTVVLILSFERLILSCLLFFLLAVAERTFKQRLLYAKLFSHLTSSRRARKSDLPHFRLNKVRNIKTWLSVRSYLKRRGPQRSVDVIVSAVFIVTLLLLSFVSLELIKDLESLHSRYNIEALLWSFTLGIYILRFMTLGTKINKKYRNLSILITEQINLYLQIEQKPHKKDELTVANSVLKLAADLIKVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2EJ20</accession>
    <name>A0A8J2EJ20_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Metalloendopeptidase</fullName>
            <ecNumber evidence="10">3.4.24.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HICCMSTLAB_LOCUS884</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="9 10">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="9 10">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="10"/>
    <dbReference type="EMBL" id="CAJNRD030001114">
        <property type="protein sequence ID" value="CAG5074112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2EJ20"/>
    <dbReference type="OrthoDB" id="7694278at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00041">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.290">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000859">
        <property type="entry name" value="CUB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001506">
        <property type="entry name" value="Peptidase_M12A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006026">
        <property type="entry name" value="Peptidase_Metallo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035914">
        <property type="entry name" value="Sperma_CUB_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127">
        <property type="entry name" value="DISCOIDIN, CUB, EGF, LAMININ , AND ZINC METALLOPROTEASE DOMAIN CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127:SF861">
        <property type="entry name" value="DORSAL-VENTRAL PATTERNING PROTEIN TOLLOID-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01400">
        <property type="entry name" value="Astacin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00431">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00480">
        <property type="entry name" value="ASTACIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00042">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00235">
        <property type="entry name" value="ZnMc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49854">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51864">
        <property type="entry name" value="ASTACIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01180">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="4 9 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 9 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 9 10" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2 9 10" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9 10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M12A" evidence="12">
        <location>
            <begin position="35"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="11">
        <location>
            <begin position="214"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="11">
        <location>
            <begin position="322"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="106"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="105"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="115"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAG5074112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="417" mass="48119" checksum="9F17CA1C881756B8" modified="2022-05-25" version="1">MYVTTDGDKEINSENIGEITSLDNMPETNKVKKTVAIRDKKQLWTSGVIPYEFENTFTESQRRIIKLGMRIYGKIAATWKTSKEIKDAAYVLSLDGCDKVPIVLHELGHVVGFYHEHEHPDRNQYVQIMERNVERGHRQEFGKFLPDEVDTLGHPYDYRSIMHYPKNAFARSDYVETIIPLQPDNGTLPVLGNRARLSAYDIAATNHLYKCPTCGGFLTNSSGSIELPDNNSEYCEWRIRVGHGERISFRIESMDIQNTADCKTGYVEIQVGFDRKNSQILGPYCGQTYDYGIIASESMIVSYVNTNKNLSYEFKAVYLKFCDEEILLLSNQKTYLETPNYLKDYKSNEDCLWHLKAEEDHVIQIQLIFLALELTAERKIHGQLLPKIIRLTFNLSAILIMKMLDFLRQLPRFHISN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2EKG0</accession>
    <name>A0A8J2EKG0_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS1937</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001116">
        <property type="protein sequence ID" value="CAG5075938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2EKG0"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5075938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="160" mass="17526" checksum="988879089FB53E45" modified="2022-05-25" version="1">MNSSKFSSLDIASMSHQISHWFLANLMAESISFMSGRNMPAFLSSVSVIEAIKEGNLKISSDFGSFGVFFDVVEGFDDVEGEDVEDVEDVEDVEGFGSVEDLDGEDSEDGEDSEDVEGLELVSSTFLALRSLENLSNPKILSKSSLSELMEIENFFPPKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2ELI3</accession>
    <name>A0A8J2ELI3_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Similar to RRP12: RRP12-like protein (Gallus gallus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HICCMSTLAB_LOCUS2441</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RRP12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001117">
        <property type="protein sequence ID" value="CAG5077388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2192888at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012978">
        <property type="entry name" value="HEAT_RRP12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057860">
        <property type="entry name" value="HEAT_RRP12_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052087">
        <property type="entry name" value="RRP12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48287">
        <property type="entry name" value="ARM REPEAT SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48287:SF1">
        <property type="entry name" value="ARM REPEAT SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25772">
        <property type="entry name" value="HEAT_RRP12_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08161">
        <property type="entry name" value="RRP12_HEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RRP12 N-terminal HEAT" evidence="6">
        <location>
            <begin position="112"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="domain" description="RRP12 HEAT" evidence="5">
        <location>
            <begin position="432"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1045"/>
            <end position="1234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1278"/>
            <end position="1307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1045"/>
            <end position="1057"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="1075"/>
            <end position="1090"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1132"/>
            <end position="1154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="1176"/>
            <end position="1192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1204"/>
            <end position="1218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF25772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAG5077388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="1307" mass="146269" checksum="3AF7CC2330851B66" modified="2022-05-25" version="1">MGKLRPRAPTRKGAKRWPKGQSSNSNPETKKYRNQARSGFGQPTLGPSRLTTEAVKRLDALQGLESSEKIEIDNDFDDASSTADTFKTFGTFASNYSNCSNTSFSRFLTHFQSTSLIHKEMLAILTAVTEVIKQNGGTESSTEYYAALMTTLEQAYSNESENSANSSESIAAILSLLGMGLKTVPKNVLKAQFSQANKVFIQILERYIERENYLIIRHCIGCLSVLLRAQEAITWSNSSTMQILYGILSLTIHSKPKVRKAAQHAVCAILKGSELMKENPPAYHPAAPEIAKHCLKQFEDAGKPGTITSTLHILTLLKDIIHQLPKTYVKSICEGLLRIMVLKNVLISSCCLQTFHSLFISKPNESILPSKLNAQIINALHEIQPNRGDTQLTLAWLAVMQEAHVNLSVNSLNLCAANIHQIILKASELWLSDKPEIITAASHTVKTLLQVCVAPLCESEITARKYEKTIREIILLIRSGMQLRYNSAWHHILHLLAVLFQIAGTKCQNELAPILSDLCELRDTHKFTYNSEVEFAVGAAVKAMGPEKVLEIIPLVTSHGIFDLKRSWLLPVLKDCITSAPLFYFKDILIPLATNCEKLSLGLKAKNDRIMSHSYGLLTSQIWSLLPNFCNNPPDIEKSFKEIARILGTILSEKKDLRIFVMTALRRLITRSIESDKKEDIKTLANYSKNYLPLLFSFYTTQPKDTVEEGQRLAAFDTIKAYLSITPPELCKDLLNTALTKLQSEENDYSKQALFSLIRILVQFTDQERLLELYNKCVVIFKSTKQPKEQKQAYKFLEEILGSEKEICKEFVQENYKAIQKVVIGAATSVCTISRASRLRCIDYLIKYNQNLEKIKFLEAIVPEVVMCVKDVKAKCRTLAYQVLNNIADRLLDKGDSFDKYIQIIVAGLGSNPAFIHATLLSLASLTYKYTGSIGISRAKEILELTCTLLTGPAREIVLSALCYVKVYLSAFPIAIIGPDLQIIMKGITGMTEDCKRHFRQKVRDILTKLIRKFGIEPISEFIPQSDEIMHKRIKNIRKIEARKQKIKEERKSKGEGDSDEEFSVKRKPKSIEDILADSDEDFDDTDDGGGDNKKKQAPKIWIKENEDDIMDFTDPAAMKNITSSKPGSANLEKKTKLNRGFKTDDVGRLIIKDSDDDSEEEKVGKKKKQLPFLGEDSDDDPDKDDEDEDGELGSKFPRKRKLSGSTDAGSVATSVASKSVYKPGGSGIHRPLKSAKLDKTLGAEYRSKKAAGDVKKKGKPDPYAYVPLTRASLNRRKKMKNASRFKGVISGAKKGAQMGKKARRKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H0C4</accession>
    <name>A0A8J2H0C4_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Similar to PFDN5: Prefoldin subunit 5 (Homo sapiens)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HICCMSTLAB_LOCUS1870</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the prefoldin subunit alpha family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001116">
        <property type="protein sequence ID" value="CAG5075805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H0C4"/>
    <dbReference type="OrthoDB" id="10267474at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016272">
        <property type="term" value="C:prefoldin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990113">
        <property type="term" value="P:RNA polymerase I assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990114">
        <property type="term" value="P:RNA polymerase II core complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990115">
        <property type="term" value="P:RNA polymerase III assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23157">
        <property type="entry name" value="Prefoldin_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.370:FF:000004">
        <property type="entry name" value="Probable prefoldin subunit 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011599">
        <property type="entry name" value="PFD_alpha_archaea"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009053">
        <property type="entry name" value="Prefoldin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004127">
        <property type="entry name" value="Prefoldin_subunit_alpha"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00293">
        <property type="entry name" value="prefoldin subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12674">
        <property type="entry name" value="PREFOLDIN SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12674:SF2">
        <property type="entry name" value="PREFOLDIN SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02996">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46579">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="22"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG5075805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="158" mass="17821" checksum="2735DE67DE466DE9" modified="2022-05-25" version="1">MSTISASEAPHLQQIDLTKLSLQQLTLLKQQLDKELNVFQDSLQTLKIAQSKFQESGFCLDKVTPEAKGKEILVPLTESMYVPGRMSDTENVLVDIGTGYFVEKNVEDAKNYFSRRVAYVTEQMEKIQVLGLEKSKIRDATIDVMSMKIQGQMQKEAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H5E7</accession>
    <name>A0A8J2H5E7_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS557</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001114">
        <property type="protein sequence ID" value="CAG5073680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H5E7"/>
    <dbReference type="OrthoDB" id="7676665at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5073680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="274" mass="31274" checksum="2B492E6D638624B7" modified="2022-05-25" version="1">MDRKNNFKNFLAAVAFFSVFAGINSAKISFHQLTAGDVVNNVNLDQLTGELMGNLFHGETGGQYVKNDFTDYWRLKSYTTAFNCNETFNAGYFPRIQVQASKKIDFNYNKLTGNVLGIEDRYIDNYMCFSFKECIVKADESVLIKLENGSDYPEDVKRWIEQTGLSGAWRENETSYVSSILTGDCVYQILVFEQPKSTTEVYDYTKHTPIHIGQISLASHNATLENWTTDFLRRTGQSLGFIKFEDKEKIFKQFNNAAVLKLELKLLPAIDSQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H5N3</accession>
    <name>A0A8J2H5N3_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS1238</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001116">
        <property type="protein sequence ID" value="CAG5075060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H5N3"/>
    <dbReference type="OrthoDB" id="7701663at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035221683" evidence="2">
        <location>
            <begin position="17"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="166"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="571"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="168"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="575"/>
            <end position="591"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5075060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="591" mass="66702" checksum="F5B816D9953F1051" modified="2022-05-25" version="1">MIWSCIIFSILLSTNADQQSTENIIKEAQQKIMVFLKEPAGVSWLTSLTQRQKSPLRTSELLTSILDKSCPAGPETKSAASKLQELLTTDNATRIEFEGWKDLMDNGPQDDVICLYRALNTTLNHTEDWQKFLTSVSEGYMVYLALDMGTKYIICLKKIPAQTRIDPTTEVPPTTTPEAPGPKMGNGSRALNDAVPLNEDSCEETTERAKNSRRQFIEVRPTSPPPCNRPIIYVLPVNYPLHAFTWYPSPQLFYQKNGPQNNFGPYVAQSNFGPYVPQSNPGYYYPSAPQRPEVYRPQNIGTYGNFEPYKNFGPVMPTQGSFEPTRTTKPVRPNFMVPMRRSPFTLEKIGPTGNPGQPRHWQVPPKCDKNTWRPECFWKPAENRHQAPISPTMIDNNFGYRKTLPVKESMKENPMLARFWKKIPQNQNWVHKKLSEIQAPMAPASPMPGPISTGSVPWIVYNQYSVKYPPGTPLYMGQNYWQGRTRPVPGIVSGPMEGRQDQAQHQGKKGKGCKNCLCNLCDRPIIVKVLMDNAGKMGPIGDSRRSIDPKTIAEVISKTDQSLEEVERQIHEIEGESNESEIEESTESSEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H6Q3</accession>
    <name>A0A8J2H6Q3_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Similar to cut-4: Cuticlin-4 (Caenorhabditis elegans)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HICCMSTLAB_LOCUS2859</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001117">
        <property type="protein sequence ID" value="CAG5078850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H6Q3"/>
    <dbReference type="OrthoDB" id="5775605at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009653">
        <property type="term" value="P:anatomical structure morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01099">
        <property type="entry name" value="PAN_AP_HGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.4.10">
        <property type="entry name" value="Hepatocyte Growth Factor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052774">
        <property type="entry name" value="Celegans_DevNeuronal_Protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056953">
        <property type="entry name" value="CUT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003609">
        <property type="entry name" value="Pan_app"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055355">
        <property type="entry name" value="ZP-C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001507">
        <property type="entry name" value="ZP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47327">
        <property type="entry name" value="FI18240P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47327:SF1">
        <property type="entry name" value="RE15579P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25057">
        <property type="entry name" value="CUT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00024">
        <property type="entry name" value="PAN_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00100">
        <property type="entry name" value="Zona_pellucida"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00473">
        <property type="entry name" value="PAN_AP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00241">
        <property type="entry name" value="ZP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57414">
        <property type="entry name" value="Hairpin loop containing domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50948">
        <property type="entry name" value="PAN"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51034">
        <property type="entry name" value="ZP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035191129" evidence="2">
        <location>
            <begin position="19"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="650"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="domain" description="Apple" evidence="3">
        <location>
            <begin position="21"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="domain" description="Apple" evidence="3">
        <location>
            <begin position="115"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="Apple" evidence="3">
        <location>
            <begin position="205"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="ZP" evidence="4">
        <location>
            <begin position="352"/>
            <end position="584"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAG5078850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="684" mass="77366" checksum="3DFE81F29A2EF3B0" modified="2022-05-25" version="1">MDRLSVISFLALFSLAIAGPAVKTTFEKSTNYDYRGTTFYTARNLSLYECQERCRNRVDCQAVAFSFVVNPLAPIQNTMCELHNETSATNPEAQPQRAVNKYYMTKLQLRSDNVCRRLWSFERVPNKMIRGLDNAVIYSSSKDACLASCLSERRFTCRSVEYNYMSLQCAMSDADRRSTGQFVQFVDAQGVDYFENLCLKPKDSCKSSKVYQLPRIGVAEDKIAQYVGLQYYVDKDLAVPTEASCKLACENESSFLCRSFLYRGPPTGDSNNCQLFHLDHYSLPDGPSTYLNYERPLIDNGERIGTYYENFCEKGTELPLYIEPTEDPSYSLRNGSNANCDKTGTCYNVTVDCKDTKIAVQVRTNKPFNGRIYALGRSETCNIDVANSDLFRLDLTMSGQDCNTQSVTGVYSNTVVLQHHSVVMTKADKIYRVKCTYDMSSKNITFGMIPIKDPDMISITSAPEAPAPKIRILDSRAREVETVRIGDKLTFRIEIPEDTPYGIFARSCVAMAKDSKSTFQIIDDEGCPVDTSIFPAFTSDRNALQSVYEAFRFTESYGVIFQCNVKYCLGPCEPAICEWDHESLESWGKRKRRSVSNSTEEDMTLSQEILVLDFGDEKQSEFFRSDASVDFNDADKTVTIIEPCPTKTSVLALGVTCALLVLLYISTVFCYYMKKWLSPRKMMH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H6Q9</accession>
    <name>A0A8J2H6Q9_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS3009</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001117">
        <property type="protein sequence ID" value="CAG5079429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H6Q9"/>
    <dbReference type="OrthoDB" id="7690945at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5079429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="197" mass="22527" checksum="B1E651975E80B175" modified="2022-05-25" version="1">MSNLEERSNISKSQFNRTRSISVQPQNIRITFLLSKFMRMVTNQETTEANSGTANGENTLNNGENSKTDESNKNEENGTTTETPVDPEEEGEVSLEEIEQDQARLDFLIGKVKKLLTDSGDYIMSVLLRILKEHLRKYSFGSRFMEKVKEMAKKYQGNVLVAKQELEKRLGRKFGKKFRMMLIKLLRTLVVGGTLPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H704</accession>
    <name>A0A8J2H704_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS3006</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001117">
        <property type="protein sequence ID" value="CAG5079418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H704"/>
    <dbReference type="OrthoDB" id="7685730at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5079418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="321" mass="36609" checksum="AAE8866CFC8C7599" modified="2022-05-25" version="1">MRLLIYVEIDSYKQGQRRLNRAFTTLDVKSTDDESNKDTSRVKPKILSNVEVAKDLDSILPMQKNTNQISISRKEKCSLKKKLNNDESQNNTLGPIDESDEVLDFQSLKVYLDKKLLDLDNSVKRNLSSEKKSLQYDLKKNFDELKNTLLANNLSGTPRLSLSDAKTKLDVKLPFADLADFKEFDDDVKSSKSKKEALMVLLRVLIYGQTTSKGCICKIASALLTKSVESHYSGTGKIIKGVGKLNFSSTETYKCMRDILPKNLVILRNAKILPEKLANGCLVVMTESMGEKKDLSRHKFFFYFYIFDFLNLKLKKKLKLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H7E7</accession>
    <name>A0A8J2H7E7_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Similar to pld3: 5'-3' exonuclease PLD3 (Xenopus laevis)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HICCMSTLAB_LOCUS3452</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the phospholipase D family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5082079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H7E7"/>
    <dbReference type="OrthoDB" id="1923775at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09106">
        <property type="entry name" value="PLDc_vPLD3_4_5_like_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09107">
        <property type="entry name" value="PLDc_vPLD3_4_5_like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.870.10">
        <property type="entry name" value="Endonuclease Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050874">
        <property type="entry name" value="Diverse_PLD-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032803">
        <property type="entry name" value="PLDc_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001736">
        <property type="entry name" value="PLipase_D/transphosphatidylase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10185:SF17">
        <property type="entry name" value="GM01519P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10185">
        <property type="entry name" value="PHOSPHOLIPASE D - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13918">
        <property type="entry name" value="PLDc_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00155">
        <property type="entry name" value="PLDc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56024">
        <property type="entry name" value="Phospholipase D/nuclease"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50035">
        <property type="entry name" value="PLD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="62"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="PLD phosphodiesterase" evidence="3">
        <location>
            <begin position="202"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="PLD phosphodiesterase" evidence="3">
        <location>
            <begin position="416"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG5082079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="514" mass="58746" checksum="7B82EA20295A280C" modified="2022-05-25" version="1">MVASKFHGKSGKKTVSENAKLETVSVDDDYDTWDQTGFMLRSDIGDHLTHSKWGAQGWCRPSCIPISIILILIVLVVLLPLLDHAEHKHLNNSSIYGNESEYICKDSCRISLVESIPIGVIYDNNSVVHRSTYSTWIELIQSAQYTIEIASLYWTMTRQDVYPDDSARENAPSQLSPNFDTEYLSKKANAEVRSLNFAALFGGGVLHTKLWLIDRTHVYVGSANMDWRSLTQVKELGVLIQNCTCLANDFAKIFEVYWQLGKDGRVPASWPDSVSTKININNPVNLTMEGNNYRGFITSSPAPLSPKGRSNDIDGILHCIEKAEKFIYISVMDYAPLTVYSPKVKYWPVIDNALRSTAIDRRIRIRLLISWWKHSRKSEDNFLASLMDLTNSYKNVRIEIRRFVVPTNEEFDKIPFGRVNHNKYMVTDSAAYIGTSNWYGDYFIDTAGIGLILEDADHKNNESIRQQLEDVFLRDWNSPYSYPLNTTPTASRIRSAVKNKMNYFLPYYHHHIHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H7J1</accession>
    <name>A0A8J2H7J1_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein sly1 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HICCMSTLAB_LOCUS3363</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Non-vital for development.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the STXBP/unc-18/SEC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5081726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H7J1"/>
    <dbReference type="OrthoDB" id="10251230at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.60:FF:000002">
        <property type="entry name" value="Sec1 family domain containing 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2060:FF:000002">
        <property type="entry name" value="sec1 family domain-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.830.10">
        <property type="entry name" value="Syntaxin Binding Protein 1, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043154">
        <property type="entry name" value="Sec-1-like_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043127">
        <property type="entry name" value="Sec-1-like_dom3a"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001619">
        <property type="entry name" value="Sec1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027482">
        <property type="entry name" value="Sec1-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036045">
        <property type="entry name" value="Sec1-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11679">
        <property type="entry name" value="VESICLE PROTEIN SORTING-ASSOCIATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00995">
        <property type="entry name" value="Sec1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005715">
        <property type="entry name" value="VPS45_Sec1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56815">
        <property type="entry name" value="Sec1/munc18-like (SM) proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00056448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00073989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG5081726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="630" mass="71498" checksum="DF1D85293B966287" modified="2022-05-25" version="1">MMTLREKQIHALKQMLNLNQQETKATTAVPTWKILIYDRVGQDIISPLISVKELRDLGITLHMQLHSDRDVIPEVPAIYFCAPTEENIGRIGQDFQSGLYDIYHLNFISPISRQKMEDLASAALLAGAVANIHKVFDQYLNFITLEDDMFVLRHQNSDMISYHAINRGEIKDTEMESIMDIIVDSLFSVFVTLGTVPIIRCPRGNAAEMVAKKLDKKLRENVWDTRNSLFQGEVGGTGHFSFQRPLLIVLDRSVDMATPLHHTWTYQALAHDVLELALNRLVVEENVGRSPAGGARSKTRPCELNNTDRFWSQHKGSPFPRVAEAIQEELEQYRVCEEEVKKLKSSMGIDGDMDIPGNMVANNTARLTNAVNSLPQLLDMKRLIDMHTTIATGILNSIKSRRLDTFFEIEEKIMSKQTLDRSILDIINDPEAGTPEDKIRLFIIYYLCTNMSEVEFNKHEAALANAGCDLNPLMYIKRWRGYTKLSGIQNSYEGGGTKTVSMFSKLMNQGSSFVMEGVKNLVVKKHNLPVTKIVDELIEMKQSPSTEDYYYLDPKQLKQIEHVPKNRTTFQDVIVFIVGGGNYIEYQNLNDYVKQKTSSGANKRVIYGSTTLINARQFIKQLSLLGQEVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H7V3</accession>
    <name>A0A8J2H7V3_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Krueppel-like factor 7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">HICCMSTLAB_LOCUS3219</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subunit">
        <text evidence="12">Interacts with FBXO38.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5081208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H7V3"/>
    <dbReference type="OrthoDB" id="4748970at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000021">
        <property type="entry name" value="Basic krueppel-like factor 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001395">
        <property type="entry name" value="Krueppel-like factor 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000624">
        <property type="entry name" value="zinc finger protein 697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235:SF150">
        <property type="entry name" value="KRUEPPEL-LIKE FACTOR LUNA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235">
        <property type="entry name" value="KRUEPPEL-LIKE TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0010">Activator</keyword>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 14" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="237"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="267"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="297"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="137"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="201"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="141"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="207"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00065453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00068015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CAG5081208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="320" mass="36009" checksum="C20F8532C7B699E0" modified="2022-05-25" version="1">MEKSYGPLTRTCYEMERYLKDEPKLQSYKKLPTELDTAPWNLFRAPPISWTATTCTTTAQFEPQIKMEVTASPDDRDPLCLDDIKFSPGDHNHNGRDRDLLDRHLDSLSMSSASSACSALSWDGSPTLSCRALILKKEPKSGQGHSNSSNSSSGSSMLDVHNLNLHGAGGRNAIVRVTATNGQGVARLISVTANDFPVVTNTQHQHTGTTAVPTTVTSRHHPRSHEHSPQDTKRRIHKCTFPGCKKVYTKSSHLKAHQRTHTGEKPYKCSWEGCEWRFARSDELTRHYRKHTGAKPFKCRHCDRCFSRSDHLALHMKRHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H899</accession>
    <name>A0A8J2H899_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS4048</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5084225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H899"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5084225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="86" mass="9399" checksum="1CC7C43555B25BCE" modified="2022-05-25" version="1">MAHLHLGSNYLAICVDANLLTLEERRLCTSILLILILILLHGAIDCPKLLALIPISVPARNTRSALSFYTPPATNNLVRSAPITRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H8I7</accession>
    <name>A0A8J2H8I7_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to ACP2: Lysosomal acid phosphatase (Bos taurus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS3757</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the histidine acid phosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5083182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H8I7"/>
    <dbReference type="OrthoDB" id="258392at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07061">
        <property type="entry name" value="HP_HAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000560">
        <property type="entry name" value="His_Pase_clade-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050645">
        <property type="entry name" value="Histidine_acid_phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11567">
        <property type="entry name" value="ACID PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11567:SF19">
        <property type="entry name" value="GH19849P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00328">
        <property type="entry name" value="His_Phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5083182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="382" mass="44042" checksum="2C001F4C4C1A5AD5" modified="2022-05-25" version="1" fragment="single">CKRIMEFTRSFWVQSCSSGRRGVCSTVIILGLLISSALLAYTAFGPKKDNRSIRQIAIDGMMQLYELGDWIRSEYDLIIGAKYDSSSAFIRSSYADRCIMSAQALLAALYRPEPGDNFIEDLPWRPVPVHSIPRDFDKLITVKYRCPKLEYALKEAYVNESIKTGKQMASYFNELSYYTGKKISTITDVEFLYNTLEIEANHGLELPEWTKKFYNEEMRRIAARSLALFTSNTLQQRLRGGPLLKEITNNMMSARNGHDKIKLYLYSAHDITLVNVLRAMGFTNELFKPDYGAALIFELVLSEYVEENNLELNVKVKYLNNTEIYEPTTLEIPHCKEPCKLVDLLRVWKDVLPVDWDSECLVDCHFLGFCNFKKIFFCTNLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H8N3</accession>
    <name>A0A8J2H8N3_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Spondin-1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">F-spondin</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HICCMSTLAB_LOCUS3173</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Extracellular space</location>
            <location evidence="1">Extracellular matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5081026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H8N3"/>
    <dbReference type="OrthoDB" id="347314at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004867">
        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00109">
        <property type="entry name" value="Kunitz-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08544">
        <property type="entry name" value="Reeler"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.410.10:FF:000046">
        <property type="entry name" value="AGAP011765-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.2130:FF:000002">
        <property type="entry name" value="Putative Spondin-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2130">
        <property type="entry name" value="F-spondin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.410.10">
        <property type="entry name" value="Pancreatic trypsin inhibitor Kunitz domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.4060">
        <property type="entry name" value="Reeler domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.100.10">
        <property type="entry name" value="Thrombospondin type-1 (TSP1) repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002223">
        <property type="entry name" value="Kunitz_BPTI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036880">
        <property type="entry name" value="Kunitz_BPTI_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020901">
        <property type="entry name" value="Prtase_inh_Kunz-CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002861">
        <property type="entry name" value="Reeler_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042307">
        <property type="entry name" value="Reeler_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051418">
        <property type="entry name" value="Spondin/Thrombospondin_T1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009465">
        <property type="entry name" value="Spondin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038678">
        <property type="entry name" value="Spondin_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000884">
        <property type="entry name" value="TSP1_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036383">
        <property type="entry name" value="TSP1_rpt_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF038123">
        <property type="entry name" value="NF038123_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11311">
        <property type="entry name" value="SPONDIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11311:SF23">
        <property type="entry name" value="SPONDIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00014">
        <property type="entry name" value="Kunitz_BPTI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02014">
        <property type="entry name" value="Reeler"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06468">
        <property type="entry name" value="Spond_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00090">
        <property type="entry name" value="TSP_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00759">
        <property type="entry name" value="BASICPTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00131">
        <property type="entry name" value="KU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00209">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57362">
        <property type="entry name" value="BPTI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82895">
        <property type="entry name" value="TSP-1 type 1 repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00280">
        <property type="entry name" value="BPTI_KUNITZ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50279">
        <property type="entry name" value="BPTI_KUNITZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51019">
        <property type="entry name" value="REELIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51020">
        <property type="entry name" value="SPONDIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50092">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="3" id="KW-0272">Extracellular matrix</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035170676" description="Spondin-1" evidence="7">
        <location>
            <begin position="22"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="domain" description="Reelin" evidence="9">
        <location>
            <begin position="8"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="Spondin" evidence="10">
        <location>
            <begin position="184"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="8">
        <location>
            <begin position="575"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00019594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00030964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAG5081026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="678" mass="75107" checksum="221E5ACEB18C4999" modified="2022-05-25" version="1" fragment="single">MSRILISVLLLLPCFVNFISASCLLQPAPFITTSPRTPGDGGFKISFSGNNSKYIPNTIYSVSIRSDPALLLTNPTANIPSFSRFRLIVDSQHSPNSPVSKVGSFQLYPDGLTSFDEDCINTVIESVDYPKSEVQVMWRSPPVGSGCVIFTAMVMTSPSVWHAADGKLVKHFCEASSDDIASSDDQLCCACDEAKYSLIMEGIWSKTTHPKDFPFSAWLTHFSDLIGASHEPSFSFWGADHIATDGFRQLAEWGSASGLEAELRAKSQYLRTLVKAAGLWYPNVNTNTTTSFRVDKKHPLLSVASMLGPSPDWVVGVSKLNLCERDCSWKKSLIIDLYPWDAGTDNGITYMSPNSETIPREKMKPITTLYPEDPRSPFYDATGKPMLPLARLYINREKIIERGCDEKLKEQIAEFEVAENTEDTSRPECATTEYSAWSSCSVTCGKGLRMRTRSYLIPEKAQMFNCFRMKTRKFLNKMGRKKCPLVPVVDKEKCMGPPCPSGSELIDPTCPVTDWSDWSPCSASCGKGVKIRTRLLMVDPARQEECSAKVEHIQQRSCLVQADCTFDMATAKVVCMEEADVGPCRGYFQRWAFDPKKLTCMSFGYGGCRGNRNNFLTFEECSSTCGIVKAALTGQEPSGQSVNSQPPPIDCMVSEWSPWSPCSVTCGSGKLTSFRMIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H9B7</accession>
    <name>A0A8J2H9B7_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Similar to Zfp26: Zinc finger protein 26 (Mus musculus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">HICCMSTLAB_LOCUS4486</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5087330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H9B7"/>
    <dbReference type="OrthoDB" id="6077919at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001227">
        <property type="term" value="F:DNA-binding transcription repressor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000100">
        <property type="entry name" value="Zinc finger 45-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1800.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012934">
        <property type="entry name" value="Znf_AD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24399:SF70">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24399">
        <property type="entry name" value="ZINC FINGER AND BTB DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07776">
        <property type="entry name" value="zf-AD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00868">
        <property type="entry name" value="zf-AD"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51915">
        <property type="entry name" value="ZAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5 10" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="ZAD" evidence="13">
        <location>
            <begin position="11"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="440"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="468"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="497"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="525"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="553"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="610"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="638"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="666"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="113"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="745"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="118"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="140"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="173"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="238"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="254"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="794"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="13"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="16"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="59"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="62"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CAG5087330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="866" mass="97966" checksum="1AF8ED247DAB0F1E" modified="2022-05-25" version="1">MEMKLPEQVHQVCRLCGQFESIYIDIFGEEGTRRLLGLKIHNKINIVIHETDPLPKTICVQCLGKLEFVCDFQEECLRTQQLLRDQYDVPSTIQDIEEKITVENLNIAESIVIPEPPSTSTNNINTDKNHNSTADIENVDPTREENFKDVIEPTEITTKPKRTTRTSPQTRSKNSDKDSHTNEDVVDEIPNRRWLRSRNITESRIKTRKKSKSKNISLKKVSSRTKSTLKEGVSIVTRLRSQNQNQNRVNSNSEAISEKTSNNSSASKTQEKVTDENGMIQIPTSALNKVLTAVSSSPEVEVSVKESSNRNGDIEDISFTLELRKKQETESTVTVLARVFPDQGSCLVGSEIINLLEDENNSELSQIINSIVKGKNSKDLPSTRTAELEELEKRLSSISDSGGGGIISSRNPEELFRIDGEEIRVDDNVESTTVDGQSGYSCKLCRKFYERRDKCTVHVKTHLGIKQYACTLCVAKFVCKSDVMKHIRCSHTNPRPMQCPKCPKRFRSKFDLTEHDNVHKGIKPYQCSDCGQSYHHKVSLQMHVKSHLPPQNLACEYCGKVFPFRTRLLSHIGSVHLKNRRNFRCRFCYNLYSSLAVLNDHIKTRHATTYTCEICSKTFKVASKYKAHVLQHSNPKPFVCNVCNNRYASKAFLNEHLLKHEGLRKHICQKCGASFAQASHLAAHRHVHGEKTHACPECGRKFNRRDNMKIEENDGLSQVICIQCLGNLDTLCDFYEKPHAIQHDLNKKEGQGNDNDNCSEDSESPDENKENELPPDSKSPPTVLEKKVTLNCKSSISPSELESTSNSTNLPSTSTSTHPPTEVISRVLADITDQHQQRPRSNLCKELFPSASRGIKRRRESSDPPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H9L4</accession>
    <name>A0A8J2H9L4_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS5058</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5088995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H9L4"/>
    <dbReference type="OrthoDB" id="7684052at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="293"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="66"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="303"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5088995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="467" mass="52541" checksum="51411B9E3FEE71E8" modified="2022-05-25" version="1">MATAKSVHQPIRLSEYINACNKSSDKKQHKPRMEPVRIKDLLLSASKARSASVVPKHTVRRALYGKSPSPSKSTSSQSSVETKSSVSISKPNTPSFKRNRSIAPKTKARQSMLPQPNFIVKKNKQKVLDSCPPTVVEERLSEVMKISPQPYQRPTVIKSVSKKRSSVVNNQPIDNCEVVHVEHGTFNNIANRTIDLEASIVDKENIPPDNLEPLTTDGANLDLFQNSRLEKIENDLQTVKDDLKIVKEQQSLLIDLVQKIFTALSVKNNEFQSQVSEPSNTSCVSSSPLISLISASPDDKENSNNNNNNNNNNNNNDKIDSNLIFNSSKRDRSEKKQRRSSSSMEERRRSARIASKLTPRKNDSFVSLENELNIVHSTTKSFSAPITPKNDKRIIKSKSARPLREYMAMKASMTFLETPDANGFRRAINYGDDTPARNKSLRRTISTKILNELEDLYNDSEETEENY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HA42</accession>
    <name>A0A8J2HA42_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Gustatory receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HICCMSTLAB_LOCUS3950</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Cell membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the insect chemoreceptor superfamily. Gustatory receptor (GR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5083856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HA42"/>
    <dbReference type="OrthoDB" id="7679932at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050909">
        <property type="term" value="P:sensory perception of taste"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013604">
        <property type="entry name" value="7TM_chemorcpt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08395">
        <property type="entry name" value="7tm_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 7" id="KW-0675">Receptor</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="63"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="104"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="157"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="189"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="272"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="308"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAG5083856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="382" mass="44310" checksum="9564E11C962BCEA0" modified="2022-05-25" version="1">MEQTFSSRNYNSNFSWQNRALIIIQYIFFKTIGLSPWALNLAQIVKKRRGRNFSNQPITITKSVYGSLYNIILILFIIIYNILFFLHEFANSQNELQLTVTVKISLRISGAMTTIVVWISYILRQKLIVQTVKKFANVDRILAKCCYKTNQPINDNYIKLAVLSHFILSFVGFIVMLKVYPIAVVPFRYVPAIINSWVMTQYSLILNMIINRLKIINTRILKLGNVETSIKPRVVLADRSPLTDPKLVAFDLRHISNAHSQLSELPSEVSNFFGFPILLVIFYSGVSGTVYSYFVIFSFFEKFKQENIINYFSVGLWYSYMILSFILMTTNVTRIKVQSKQTADAIHLVLDRCLMDQKIEDQVNMIFFILASCTQKVNYNYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HA70</accession>
    <name>A0A8J2HA70_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Threonylcarbamoyl-AMP synthase</fullName>
            <ecNumber evidence="5">2.7.7.87</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">HICCMSTLAB_LOCUS5029</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="14">Cytoplasmic and mitochondrial threonylcarbamoyl-AMP synthase required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Catalyzes the conversion of L-threonine, HCO(3)(-)/CO(2) and ATP to give threonylcarbamoyl-AMP (TC-AMP) as the acyladenylate intermediate, with the release of diphosphate. Participates in t(6)A37 formation in cytoplasmic and mitochondrial tRNAs. May regulate the activity of some transporters.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-threonine + hydrogencarbonate + ATP = L-threonylcarbamoyladenylate + diphosphate + H2O</text>
            <dbReference type="Rhea" id="RHEA:36407"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
            <dbReference type="ChEBI" id="CHEBI:73682"/>
            <dbReference type="EC" id="2.7.7.87"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="15">Interacts with RSC1A1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the SUA5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.87" evidence="5"/>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5088927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HA70"/>
    <dbReference type="OrthoDB" id="3648309at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061710">
        <property type="term" value="F:L-threonylcarbamoyladenylate synthase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006450">
        <property type="term" value="P:regulation of translational fidelity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.870.10:FF:000007">
        <property type="entry name" value="YrdC N6-threonylcarbamoyltransferase domain containing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.870.10">
        <property type="entry name" value="DHBP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017945">
        <property type="entry name" value="DHBP_synth_RibB-like_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006070">
        <property type="entry name" value="Sua5-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050156">
        <property type="entry name" value="TC-AMP_synthase_SUA5"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00057">
        <property type="entry name" value="L-threonylcarbamoyladenylate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17490">
        <property type="entry name" value="SUA5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17490:SF10">
        <property type="entry name" value="THREONYLCARBAMOYL-AMP SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01300">
        <property type="entry name" value="Sua5_yciO_yrdC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55821">
        <property type="entry name" value="YrdC/RibB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51163">
        <property type="entry name" value="YRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <keyword evidence="10" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="YrdC-like" evidence="16">
        <location>
            <begin position="13"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00015492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00058524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00063146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CAG5088927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="222" mass="24824" checksum="E07AB43194D4254B" modified="2022-05-25" version="1">MSPRAKHWFIGGDRSLAVGVKLLREKKVIALPTDTIYGLATLAQDTECVEKLYEIKGRDKNKPFAIAVNSVKDISRWGHVDHILPDLLLTLLPGQVTIVVKRTGNLNPKLNPGIDTIGVRVADSKFLRSLAKVLNEPLALTSANRSNEPSSLTTEEFSELWPVIDGIFYNIPNKCKLDEKYRVGSTIVDLTVSGRYKIVRPGIVLDRTLKYLHYYGFKPVEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HAG0</accession>
    <name>A0A8J2HAG0_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS5678</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5090560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HAG0"/>
    <dbReference type="OrthoDB" id="7694315at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5090560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="101" mass="11630" checksum="EEDE5A7E2E61C145" modified="2022-05-25" version="1">MASRQQFSDLLLYPRTMVSEKKNLQANISLLCWYSNKFMQLSRANAFQNCIKTGSIINEGHIDLRNFLHDAKKMLIEKIQTTLKSEGSIKVSTTLICKFEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HAG2</accession>
    <name>A0A8J2HAG2_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Similar to ZKSCAN8: Zinc finger protein with KRAB and SCAN domains 8 (Homo sapiens)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HICCMSTLAB_LOCUS5164</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5089249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HAG2"/>
    <dbReference type="OrthoDB" id="6077919at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001235">
        <property type="entry name" value="Si:ch211-119o8.6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000702">
        <property type="entry name" value="Transcription factor E4F1 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000446">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000870">
        <property type="entry name" value="zinc finger protein 197 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002343">
        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050329">
        <property type="entry name" value="GLI_C2H2-zinc-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19818:SF157">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19818">
        <property type="entry name" value="ZINC FINGER PROTEIN ZIC AND GLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="71"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="98"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="126"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="154"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="182"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="210"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="247"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="274"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAG5089249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="305" mass="36398" checksum="B6D4A248AE61FC3B" modified="2022-05-25" version="1">MDENYPFEKVIIKVEKDEEDFQEDQSIFNYQDYNFGEDYPVDIEDIKIEEPDNFQEELKESKVQKKRFKKYECDYCMHKFSHKNALLVHINKHMTTKYRCEICSKSYISKEGLTLHTARHTGDKPYECEICASKFVNRYSCDNHMRIHNGEKPFACNVCSSKFRNKSHLTAHQRIHSGDKPFTCPICSAKFRYSASLKNHIRAHTGERPYSCEKCSAKFRDCSSLRNHKLAHTGERKKRRKQREKRLSCEICSCKFEKNYLKIHMRRHTGERPFDCQVCSSKYIRKSSLTRHMKTHQKIYKEQNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HAJ4</accession>
    <name>A0A8J2HAJ4_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to SPSB3: SPRY domain-containing SOCS box protein 3 (Homo sapiens)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS5758</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5090818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HAJ4"/>
    <dbReference type="OrthoDB" id="5951542at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12876">
        <property type="entry name" value="SPRY_SOCS3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050672">
        <property type="entry name" value="FBXO45-Fsn/SPSB_families"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035754">
        <property type="entry name" value="SPRY_SPSB3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12245">
        <property type="entry name" value="SPRY DOMAIN CONTAINING SOCS BOX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12245:SF5">
        <property type="entry name" value="SPRY DOMAIN-CONTAINING SOCS BOX PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="B30.2/SPRY" evidence="2">
        <location>
            <begin position="1"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5090818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="253" mass="29002" checksum="3958A6C9A6F95863" modified="2022-05-25" version="1" fragment="single">YEWAWDERLTSRKSLLSQNNLEVKFHPGYSDGTVAVRGDKILSKGRHHYWEVEMLSQIYGTDVMVGVGTAKVNINERDKFLSLLGQDRESWGLSYKGKIHHDGEIKDYSEPFAQGSVVGLHLDTWKGTLQFFINNKPFGIAFTGLYGIELYPIISSTAANSCMRITQSLSVPVSLQMDCLGLLKPLHRSYLSTAFPGLRYLLDSKFAEVLRKKRDNDDSEDSEYEFPEEYLILDDFDFALVGRGRRKKKRMIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HBQ4</accession>
    <name>A0A8J2HBQ4_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cc_ep2.5_CcPL2.093_pseudo</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS6148</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5092458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HBQ4"/>
    <dbReference type="OrthoDB" id="6925838at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5092458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="173" mass="19643" checksum="8FBFA0BD43C92FE6" modified="2022-05-25" version="1">MMLYFLFLVADPLQDRRSNPNSESWYGNNPDYQHLINTASQYGQNPGHQNSVADTRWDDRQSYPQKPIPNGSLNNQSPGNQKPGFLKPSRKIKPFELTPDLKMAYESIDSQRPAGSGSKTYLGSITVLKGNTYNVDPNSTNIYGSVTQISGSYLYPVEQERLDRINQKFFKRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HBX8</accession>
    <name>A0A8J2HBX8_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">GTPase Era, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">ERA-like protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HICCMSTLAB_LOCUS4887</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Era GTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5088540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HBX8"/>
    <dbReference type="OrthoDB" id="8954335at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043024">
        <property type="term" value="F:ribosomal small subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000028">
        <property type="term" value="P:ribosomal small subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22534">
        <property type="entry name" value="KH-II_Era"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002220">
        <property type="entry name" value="GTPase Era, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005662">
        <property type="entry name" value="GTPase_Era-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009019">
        <property type="entry name" value="KH_sf_prok-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42698">
        <property type="entry name" value="GTPASE ERA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42698:SF1">
        <property type="entry name" value="GTPASE ERA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54814">
        <property type="entry name" value="Prokaryotic type KH domain (KH-domain type II)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="G" evidence="6">
        <location>
            <begin position="58"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00019149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00030975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAG5088540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="338" mass="38257" checksum="E369F1D6DF1ECEB3" modified="2022-05-25" version="1">MLITLERTILRIKSRFLRFYSADVHNVRFNHPQSYEDHVFDASWEPSEIRRDDAKTLRISMLGLPNVGKSTLINQLVGRPVCAASSKVQTTKKKSEAIYMDDNTQLIFIDTPGLVKSSDMKKYDLEKTFRTDVDKALATCDIVGVVQDVGNKVRADVIDPRVLVLLKNLKIGIPTLLILNKVDKIKKKKVLLELVDVLTSDKNWPNFSDIFMSYLLDSAKPRDWDYESKKISSDSPESIIEQTVRAKFMDALPNELPYAIIVQLEHYSVLKDDSISTVVAVLTPSDRISNLVMGKGGCRVRAVAKAVEQELSQAFSTTVRLKIAVKFSELKDEPEFKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HBZ5</accession>
    <name>A0A8J2HBZ5_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS6671</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5093213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HBZ5"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="242"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="306"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="254"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="273"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="306"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="316"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5093213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="356" mass="41069" checksum="F9F41C5ECAB1E53F" modified="2022-05-25" version="1">MIRYIELNAPEDDREVVKRTFEKTAATTLYEYLPDYLRCLCKIRKAETLERMYAAIESDAHRRPNRRRTVDEDVPVVGEAFPPALEYYRRPGPPGLEGNRHYPQMPRPSREYDDRGNYRDHQRTLVYQDTASFAVTPTHDSYFTPTDHEMYYDSIEGHSGPHQGSAFTFGATEPRYSYQYNNHPLRSYSRPPINNRYHPGVLGPTRKTVHYANDEDSEEAKRRHKIDPSVFCDCPFCPRGERKSPPPDYLNGQGARQTEAMSSTPNLPPRWSPNPTYRPQNTYPTHNPTYQSSYPRSILQNHQNQSLNNTSQSLNPASKAQTDPLPYQNQSSTQPTPNQRITIGELKAQTRSNQNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HC53</accession>
    <name>A0A8J2HC53_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Tetraspanin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HICCMSTLAB_LOCUS4578</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Membrane</location>
            <topology evidence="1 7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the tetraspanin (TM4SF) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5087687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HC53"/>
    <dbReference type="OrthoDB" id="2014092at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1450.10">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018499">
        <property type="entry name" value="Tetraspanin/Peripherin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000301">
        <property type="entry name" value="Tetraspanin_animals"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008952">
        <property type="entry name" value="Tetraspanin_EC2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19282">
        <property type="entry name" value="TETRASPANIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19282:SF431">
        <property type="entry name" value="TETRASPANIN 26A, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00335">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002419">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00259">
        <property type="entry name" value="TMFOUR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48652">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="28"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="57"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="220"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="121"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR002419-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG5087687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="256" mass="28409" checksum="17FC1455B382538D" modified="2022-05-25" version="1">MAVGVWAWKEKETFSNLSRLTNVALDPAFILILVGTVTSVIGFTGCVGALRENTCLLATYAIFLGTLLLLEMTIGVLGFIFKDWIKSQATGGFQAFIIHYRDDPDQQNLIDWIQEDWLQCCGIEGPKDWDRNNYFNCSSSEIGSSEACGVPFSCCKREPNPGERSIFERGCLRAGEEWLELNLVPVAGTIVSTMVLQTSDVSIYEKGCIQAGEEWMEKNLLVIATTAIITAFAQILGICFAQNLRADIFAQKAKWH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HC82</accession>
    <name>A0A8J2HC82_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zinc finger-containing ubiquitin peptidase 1</fullName>
            <ecNumber evidence="6">3.4.19.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Lys-63-specific deubiquitinase ZUFSP</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">Zinc finger with UFM1-specific peptidase domain protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">HICCMSTLAB_LOCUS6508</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="18">Deubiquitinase with endodeubiquitinase activity that specifically interacts with and cleaves 'Lys-63'-linked long polyubiquitin chains. Shows only weak activity against 'Lys-11' and 'Lys-48'-linked chains. Plays an important role in genome stability pathways, functioning to prevent spontaneous DNA damage and also promote cellular survival in response to exogenous DNA damage. Modulates the ubiquitination status of replication protein A (RPA) complex proteins in response to replication stress.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="5">Interacts with RPA1 and RPA2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the peptidase C78 family. ZUFSP subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="6"/>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5092990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HC82"/>
    <dbReference type="OrthoDB" id="288987at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071567">
        <property type="term" value="F:deUFMylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.130:FF:000002">
        <property type="entry name" value="Zinc finger containing ubiquitin peptidase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012462">
        <property type="entry name" value="UFSP1/2_DUB_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48153:SF4">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE MUG105"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48153">
        <property type="entry name" value="UFM1-SPECIFIC PROTEASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07910">
        <property type="entry name" value="Peptidase_C78"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0007">Acetylation</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0677">Repeat</keyword>
    <keyword evidence="13" id="KW-0862">Zinc</keyword>
    <keyword evidence="11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="20">
        <location>
            <begin position="183"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="253"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="61"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00021993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00029662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00031481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00045669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="CAG5092990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="618" mass="69195" checksum="94F1118CCE59EE7D" modified="2022-05-25" version="1">MTIKNQIGCSRKRKRTPENDMMAFIDDDSLMDDSIKEEESQDLSSSSSSLFTRPHMLNGWSESSARNGESSSCNYKSSSSNDSPKNHSSTSNVNNINNNNNTPASSINGEHSAGHGSPLRTSLNLQLRSYATPKPRVQECPMCPFSSDNPSKLEEHINRQHFDLTSPSFPPESPPTRDGSYNCPLCVTSFPNPSDLELHVNIEHKDILSPAKGTTSTPEVSSNEPPACPVCLSTSFRTNEELTVHIEEHFAKKSSTPSPIDVADSSLTSSDRMLARDMERREKEVRKLREQREFEMLRAQYGMDNQGNFREQSVTNMQRAVYAGEMTVADYYERQIELKAAENNGIDDGSSCTRGLVSRVRAVSQACHNVINTWMCSTVDHYASTYGDKGWGCGYRNTQMLISSLLQHTGFNELVYRAWSSVAAGSTANPMRSSMPSISRLQRMIEWAWSLGFDVQGAEQLGGKLVNTRKWIGATEVVTLLSSLRIRCQLVDFHRPTSPDGSHPEMFQWVLQYFQRNDEFKPPLYLQHQGHSRTIMGVEQLRDGSITMLVLDPSHTPVQMGQFNSTSSAPGAMRLIRKSTAAMKARQYQIVAVVGTVENESRYQMSKVLRTTRIPQDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HCE9</accession>
    <name>A0A8J2HCE9_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS6944</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5093608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HCE9"/>
    <dbReference type="OrthoDB" id="504708at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5093608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="233" mass="27231" checksum="453A2CF503DC7ACD" modified="2022-05-25" version="1">MQTTTDLFQMCDKFGICYDVNFLNTLNKTKDNYSTEINATVKEIEEFSYTTDNCLDPIKVCVDNQCKCLHGMIQWNNKCYSSRGGFCLDSSHCLSTHLEYTFCWGNERTERSPNILCHAVLGYFSVAGVLVNHSDSTSHCRYAWNQPQDSNRFEFFKPNEKIVWKNSNIKLDNAIYGGPDYRSWYHLYLICQTEHNRIKYLGQLLKPNYNVCRFILNGTFHESKIFDVLVYDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HCV6</accession>
    <name>A0A8J2HCV6_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Similar to cpo: Protein couch potato (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HICCMSTLAB_LOCUS5009</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5088868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HCV6"/>
    <dbReference type="OrthoDB" id="431169at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12684">
        <property type="entry name" value="RRM_cpo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12245">
        <property type="entry name" value="RRM_scw1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000037">
        <property type="entry name" value="RNA-binding protein with multiple splicing 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034788">
        <property type="entry name" value="Cpo_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10501">
        <property type="entry name" value="U1 SMALL NUCLEAR RIBONUCLEOPROTEIN A/U2 SMALL NUCLEAR RIBONUCLEOPROTEIN B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="6"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="185"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAG5088868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="285" mass="30741" checksum="1E36934EF2CFE7D0" modified="2022-05-25" version="1" fragment="single">ILFQVRTLFVSGLPMDAKPRELYLLFRAYEGYENSLLKVTSKNGKTASPVGFVTFHTRAGAEAAKQDLQQGVKFDPDMPQTIRLEFAKSNTKVSKPKQPAAAAATSHPALMHPLTGHIGNPFFPSGPELWHHPLAYSAAGELQGTLQHATLVHPALHPQVPVPLASPVGSSSSQPSIAVSNAPCSTLFVANLGQFVSEHELTEIFNSFSGFCRLRMHTKGGSPVAFVEFQDVRYAAQAMGALQGSLLLSSDRGPIRIEYAKSKMAEVGFTNLWIEGSKGEKNGQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HCY3</accession>
    <name>A0A8J2HCY3_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Similar to AdipoR: Adiponectin receptor protein (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HICCMSTLAB_LOCUS5767</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ADIPOR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5090848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HCY3"/>
    <dbReference type="OrthoDB" id="5585746at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038023">
        <property type="term" value="F:signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033211">
        <property type="term" value="P:adiponectin-activated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004254">
        <property type="entry name" value="AdipoR/HlyIII-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20855:SF52">
        <property type="entry name" value="ADIPONECTIN RECEPTOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20855">
        <property type="entry name" value="ADIPOR/PROGESTIN RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03006">
        <property type="entry name" value="HlyIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0675">Receptor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="173"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="204"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="244"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="269"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="300"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="333"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="372"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="224"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="370"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="374"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR604254-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAG5090848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="410" mass="46140" checksum="F35D98899FF36AE9" modified="2022-05-25" version="1">MITDNDEIFEDKPGSDTSSVETAKESPSVFRHRIPWSDRGSLSHDIPGLHEVKELLDDDDASCLAEEEDGVGCPLPSTPEDDHLLDCEMTEVLKAGVLSDEIDLGALAHNAAEQAEEFVRKVWEASWNQCHFRNLPRWLQDNDFLHAGHRPPLPSFYACFKSIFRIHTETGNIWTHLLGCVAFIGIAIFFLTRPPMEIHLEEKIVFGTFFAGAIICLGMSFAFHTVHCHSECVGKLFSKLDYCGIAMLIMGSFVPWLYYGFYCDYQPKLIYLSVVVVLGITSIVVSLWERFGEPNYRPLRAGVFMGFGLSGIIPAVHYAIAEGWFKAISQASLGWLILMGCLYILGALFYALRVPERFFPGKFDIWFQSHQIFHVLVIAAAFVHYHGITEMAMHRMTVGDCSNPSQVLAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HD36</accession>
    <name>A0A8J2HD36_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SH3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HICCMSTLAB_LOCUS5329</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5089678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HD36"/>
    <dbReference type="OrthoDB" id="6415921at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00174">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="4">
        <location>
            <begin position="370"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="60"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="101"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="68"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="101"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="119"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="137"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="156"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="189"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAG5089678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="430" mass="48191" checksum="76DB810AC8031655" modified="2022-05-25" version="1" fragment="single">CGTLISGDLKRRQWNVDEDIRNEETEQVNLEEDNDSPKEDACTLQEVDLVANCPLLRVTPSRTPSPAPSYLSSSYKSMGQRPSTLLRPKISLTWVLRGQQHQHNDVNNTASIQESQIIRKSKDRSSRRSVKSIKSIKTKETKELNKQPETPVSSKADQKQDSKDPPETDKVKRAVSEPFLALKESATREKHHRHRRTKRNHNPRPPTRFGYEIADLDSFLTKASIERPANIPVVLSFPTTLYQTQSGGQDEIALPLGTVVNAVFKNQAWLYVQTPHGQEGYVGYAACLPLGILPQPTCGPCWEDSTDVFPRPIGNMTDTEKLRDTRSECGVRERSSRVRRGHRDAVSACGERSVDRLYLRAAANARTKGSRQTLLVIRSDYEGRGSNSISVSKGDVVALLSDHVQGWFWVRSRDSREGFIPAVIAGHGFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HDM9</accession>
    <name>A0A8J2HDM9_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HICCMSTLAB_LOCUS5662</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5090512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HDM9"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="1 3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="4">
        <location>
            <begin position="454"/>
            <end position="495"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAG5090512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="504" mass="58568" checksum="75185B11D59EB285" modified="2022-05-25" version="1">MELIESDGFKPNSKIYSYGDWIYHKCQGTSNRYYCAQHSTKFACPVVLNKCDDGEIKVDESEHNHIQPNRNTKLEITKKLKKEALSNLPVHEIVNKVLKIYKNPTINVAAARQIVIRTIAEHQKDSPSNMFELSEYLQSNELYSQFFVGEAITKNRKEIAVFLGSTMLINKLKSSCRINLEAYQLLTFHLHEGNNGITALYILCSARSYELYGCIFKKLKEMKILNFTKAMCPYDHIIVETLKEVLPEVIIRGSLFSFVKLMTRKWSSLDLPKDYTHTVFKTSMILKLLPPEKVKEGIKVVKHQAELESDRFEDLLAFAKFAEKCSPLIEESTFTGDNINEAIDYAESHNLHMVKQLGKHEGLHSFLNLSKSRGNHNKMKVNVRVTKSIVKEQEKFKNKNQTVEKFLNFIMQTNMEKFLMLQSSWPQYRDDAGKLLRLPNFHCYHLESKPSEDCVYCMTEKACVQINLCKHVIACMTCWIFNYYSMKRRRCPLCRTIYDKVTIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HGF1</accession>
    <name>A0A8J2HGF1_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Lipocalin/cytosolic fatty-acid binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS9486</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5100303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HGF1"/>
    <dbReference type="OrthoDB" id="7679992at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012674">
        <property type="entry name" value="Calycin"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50814">
        <property type="entry name" value="Lipocalins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035272206" description="Lipocalin/cytosolic fatty-acid binding domain-containing protein" evidence="1">
        <location>
            <begin position="24"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5100303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="118" mass="13176" checksum="2EF6D7C149DD60FB" modified="2022-05-25" version="1">MIENIIPRSSLWIILLSLYLCSCKCPLSGDDKVVDYNKMVGEWYVVAASPVRDKVGKCLHFNVVMNGTDSFAMNFTTTSPISNGRLLWRINGKQSENETIATWQLNGSPRVLGNIIPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HGW1</accession>
    <name>A0A8J2HGW1_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HICCMSTLAB_LOCUS8492</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5097001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="410721at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00030">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041489">
        <property type="entry name" value="PDZ_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46848">
        <property type="entry name" value="REGULATOR OF G-PROTEIN SIGNALING 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46848:SF1">
        <property type="entry name" value="REGULATOR OF G-PROTEIN SIGNALING 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17820">
        <property type="entry name" value="PDZ_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2" evidence="2">
        <location>
            <begin position="550"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="3">
        <location>
            <begin position="749"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="327"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="364"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1210"/>
            <end position="1233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1304"/>
            <end position="1459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1482"/>
            <end position="1568"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1598"/>
            <end position="1632"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="375"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="408"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1210"/>
            <end position="1220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1221"/>
            <end position="1232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1304"/>
            <end position="1333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1353"/>
            <end position="1377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1386"/>
            <end position="1400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1401"/>
            <end position="1416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1432"/>
            <end position="1446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1530"/>
            <end position="1539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1553"/>
            <end position="1567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1604"/>
            <end position="1617"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1742"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG5097001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="1742" mass="195192" checksum="183F3AA86640CA6F" modified="2022-05-25" version="1" fragment="single">MLSFRLSNHKTNVLTQMLKWTVSRSMSTASSTSYVPPTMHKTTRKPFRDLSNTPPADGTRSKVTPQTTVDVDNSNPSSKSTPGRRRRCRSHGSDVRAYFQATKPHTRSNKRQSIANETLELPKTESSYHRTPRIDTDIGPLTYIPDNYHISKCPVALTLPTDPTSLPHTYSKTFHHVNNNNNELPQNVMNEARANLQSHVSDFFQQISVAGSPEDVMEAGSVPLSRSRLFFRNIDRMKSSSSPEGKPLCYPKLAKISKLHARCRTPYHTKAPQFKLRETPLAKELASLKIDQDIPKFENMDNTVTEILNKQQQETNLCSNKIDDEIDKKTRSDGDSVPTRLHLNDKDSIDDKDTCKFIEEQMINEDEGKADHNDSSVSSASQLLENPSPISWAFRSPSIDSDGEFTLKRQRGIRRKRQQKDQGINKSSGSKRAKTRSQSVSPATRKKILEGDEPPIQAVNLHVKKITLETDLDSIFDEKIDSKILNHYQKNEETKMNLWDLDSPKSSLIDDFPSSKSSFVHSANETSETPLIATVRRCLKYSPEVEIPESNSRSSIELEYNIIGDSIHIRVIRCKDLKRSYEGPIHAYVKVSLKNPNGGGVVKRTAVHRATPNPVFHETLILPYPNHNCTDRSTSLDIAVWHRDRRARRSELLGCMTLPLPLAQDKEATWHPLQVGSVRKTSTPYAKLSQDCTVSPPLSKDGDHTDNNSNADDFTYLRHLELEPLDPLTGLPLNPGFTARGGRTPCTITRRLIRQSGAKQIPWGFSLSWGRPPRVERVDPGSPAERAGLMPGDHVVFVDTTNVVTRAREDILNFIQAATNQLILEIYRKSGAHVNTQRPSLVNVTLQPALDQPNGQGAIAFTAEVFPHISPDAPPEEELNVREARYWGALKSGITRFCVPLAERRDILSATDHAILFQNLDELLKLSEEIKDEGGDVESYLTRIPRITASYRRYLSGLQRACCLLVALRRNSVFAKLVCEPAVPHKRRPDITGVLLLPLEHYREMTRLLGLASPRNCQQARDLAQGYREATANAGVMEPPRDTGRPLLSLQEVESRLVLFGGALVKVEGRRLQPSWALLLSDLLVFARVSRDRVLFVTEEPLRLSSIAEACFTVRKRPTEFRLQVSITPNGSYENGHIDAMQSGGCSPHSRPRRRILILRAPTPELKAVWHNLLQRQIIYVNTGCTDTPSIHSPEESHYTGNHFTIACDPNTSPQITISRNSREPEEDKLQDDQDNLESIIKPINDSSQNNIHLAQWVRNSHQIPPPDYEVPPEEWTVEELAARAPKESISSNVNEQVIEENVATNSDQEQHSTTSSASLSTVKSTTVNSKKNGSFKDAPSGSINICRRSGCPTPPPLRDPFSPLPPKISILPPTPDLCPMYKLKNGSQDSPSKNCTTADENTEDGSEDDLDCDEEPPYRALRRFGTMSSLDQEDELDDQGDDDNRDLESPPTVLKSWTARASDFVVSKMVFLEQLSEGVGSYLLQPPVPPERTEFSLDPNDDEGTTSGGTSGDDIWGTPTSGGPDDDSFTASPPSINGNVLGEDNYGLTLNTDDDADESGDSEDCNVPEISMDQLLGSSNFSSLRCILNRRRLEPLPEEDDSSDLHKKLLDVDSGKESSQIDNPPVKKTEKRVTLVETATTPKPLDVGRILKPALKNSIANSSNEAESISRMLDRRRLKRMDLEHERRKHLEELRRRSERIDEVSEDDQDEQIPVRPRETTTFLNRLRIRRRSIKLLSFLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HHA1</accession>
    <name>A0A8J2HHA1_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Similar to CDH23: Cadherin-23 (Homo sapiens)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">HICCMSTLAB_LOCUS7665</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5095350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6491773at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048513">
        <property type="term" value="P:animal organ development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048589">
        <property type="term" value="P:developmental growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001736">
        <property type="term" value="P:establishment of planar polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007163">
        <property type="term" value="P:establishment or maintenance of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048731">
        <property type="term" value="P:system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd11304">
        <property type="entry name" value="Cadherin_repeat"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000168">
        <property type="entry name" value="Cadherin-related family member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000020">
        <property type="entry name" value="Dachsous cadherin-related 1b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000021">
        <property type="entry name" value="FAT atypical cadherin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000039">
        <property type="entry name" value="FAT atypical cadherin 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000118">
        <property type="entry name" value="protocadherin Fat 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.60">
        <property type="entry name" value="Cadherins"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002126">
        <property type="entry name" value="Cadherin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015919">
        <property type="entry name" value="Cadherin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020894">
        <property type="entry name" value="Cadherin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050174">
        <property type="entry name" value="Protocadherin/Cadherin-CA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24028">
        <property type="entry name" value="CADHERIN-87A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24028:SF263">
        <property type="entry name" value="CADHERIN-RELATED FAMILY MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00028">
        <property type="entry name" value="Cadherin"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00205">
        <property type="entry name" value="CADHERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00112">
        <property type="entry name" value="CA"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49313">
        <property type="entry name" value="Cadherin-like"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00232">
        <property type="entry name" value="CADHERIN_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50268">
        <property type="entry name" value="CADHERIN_2"/>
        <property type="match status" value="14"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 12" id="KW-0106">Calcium</keyword>
    <keyword evidence="7" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 14" id="KW-0732">Signal</keyword>
    <keyword evidence="3 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035147184" evidence="14">
        <location>
            <begin position="27"/>
            <end position="1851"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1755"/>
            <end position="1778"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="15">
        <location>
            <begin position="46"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="15">
        <location>
            <begin position="139"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="15">
        <location>
            <begin position="261"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="15">
        <location>
            <begin position="381"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="15">
        <location>
            <begin position="502"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="15">
        <location>
            <begin position="604"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="15">
        <location>
            <begin position="724"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="15">
        <location>
            <begin position="831"/>
            <end position="954"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="15">
        <location>
            <begin position="962"/>
            <end position="1069"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="15">
        <location>
            <begin position="1070"/>
            <end position="1186"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="15">
        <location>
            <begin position="1187"/>
            <end position="1295"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="15">
        <location>
            <begin position="1306"/>
            <end position="1408"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="15">
        <location>
            <begin position="1413"/>
            <end position="1531"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="15">
        <location>
            <begin position="1532"/>
            <end position="1655"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CAG5095350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="1851" mass="203383" checksum="A0B2862695A3D284" modified="2022-05-25" version="1">MTPLVDLVVIMRILIWLALLTSGVRGQVINRAPHFIHGGDMSRLAVSEGTLPGVAVYTLQGEDPEGSKLHYSISGEYFTVNRDNGVVTLRKFLDREAQDIIEVIISITDEGVAGSEPNTVSLRREIAVLDENDNPPVYHGRPYATRIPESASVGSLLLPEGTVTLSDRDGGVNADVDVRCVTASTDDDTCSVFSVTTEKITDGKYDVRISVLQPLNYERRSSYLITLLATDGASDPAKRLHAKATVAVDVIDVQDQPPIFLNAPYSAAIPENTSPGYTVMTIRARDGDTGQSRSVLLTLEGDDLNHFDLKTSREGDITVGTLVTTEIPLDREESRILHDGGIYTFRVRATELINNEIPADSTVSVVTIVVTDVDDLSPKFSDDFYSIKVLEDIGLDTPLPGLNMVVSDDDVGDNAKFRLSLRDAPGYPGISRAFLVTPEFAQGRVPVVIKVRDPQVLDYDVEILTKRELEFDVTASVGDRVAAFSRVHISILDANDHAPEFTEAVYKLSVREDSKPGVKFGDIVAIDLDSGAYGELTYTLRGFGADKFRTDSKQGGIWVAKPLDYETQKSYSLTMEARDGGGRVSTVNILIELDDVNDNPPIFEQKEYSRTVREGATSFEPQMFVRATDIDGPVHGNGKVTYSIARHNGMTEDVFKINAETGEVLMNSPAKSGDTERGLYELDIRATDHGYPPLYSEAKLLVRVGVPGNQRPVFRGNFKGGPPGPNSYRARLLENASPGTEVIRVVANDPDGRDSLLQYYIASGAKDNFVIDSSSGIITVSPDARLDLDTGGDKYEVIIYAVDSGTPVRETATTTVTVTILDVNNKPPKFENSTYLVYVSERAAIGDSVLKVTAADPDTDSKLKYSIVEPIKAVDKTGVALKSTSPYDYKSAFRINSTSGLISVNKVLDYQVAAVIMLTVQVEDVNAIVDKSQQVDRTEVTIYIQAFSDDNPIFLNPGWSANNPVIRVTVPEEQPLGTTLLMLSAKELSGHAVQRFELVRDDQDQDFVNVGVQSGNVVLSKRLDYESLSQKFIQFKVRALALDYDITRRMSEATVIVEVQDVNDNSPTFTQKDYKIAVLEDSKPGKIILNIKAVDMDSSSTEQEIRRGFGEVRYALTGENANLFEIDPMSGNIQIAENTNLDRERQSVLRFFVIASDMPQGGAEQKTARVLVTVDVLDVNDNAPSFLQPSYTAVIPENAPMNVSIVNITATDPDEGKGGEIHFEIIDEGEASGLLKINHKTGEISSKKKLTGKGRTEPYIMRVRAQDSGQPVLHSDVSLTLYIGDVVSNDGVPLFIRPTLDEVAYVSENSTIGSPVFQVVASDPDDPNLPNGKITFKFLEDGNFGNDASAFRINGDTGLITTRKLLDREAKDSYTLILIAQDLGDPPQQASRVLQVIINDIDDHKPHFKRSLDSPPVELSIQEEVPEGTVIGVIEAIDEDIGENGIIDYVIIYGNEGSLFAIERLPNNSAVIKTVGRLDRETSAKHLITVKCFKYPVQKSDVVPKPYNRQDPSERQVLIRVMDVDDNKPRFRKDNITIGVRLNVPIDTSLITLEAYDEDSDALPINYTMGEVSFTSLAEPSMVKRKIPSYLALNPATGELRTTGSMAGFSDGFMEVPITANNSRVPGRETNVTLRIFLLRDRDMLKFVFSKPPVEVRKTLEEFEKAVQQALALPITVNVYDTQFYSKDDNSLDFSSTSSCFQMVGREAYDLGEMKALLRDPKNEELKKVYEKFHVERVQHCAATVARADASRTQMWVLAIAALVGVAAVVSSCTLCCMHSKYKRRVKRARIREQTRPPLSYVSSGPGMVNAQSHTTLGTLPGTMVTIGPHEGPYEWGADTTLYHPSTLSRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HHD7</accession>
    <name>A0A8J2HHD7_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 10">peptidylprolyl isomerase</fullName>
            <ecNumber evidence="2 10">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HICCMSTLAB_LOCUS9313</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="2 10"/>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5099945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HHD7"/>
    <dbReference type="OrthoDB" id="1902587at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.50.40:FF:000006">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052273">
        <property type="entry name" value="PPIase_FKBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001179">
        <property type="entry name" value="PPIase_FKBP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46222">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE FKBP7/14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46222:SF3">
        <property type="entry name" value="PEPTIDYLPROLYL ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00254">
        <property type="entry name" value="FKBP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54534">
        <property type="entry name" value="FKBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50059">
        <property type="entry name" value="FKBP_PPIASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 10 13" id="KW-0413">Isomerase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="7 10" id="KW-0697">Rotamase</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="domain" description="PPIase FKBP-type" evidence="11">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="12">
        <location>
            <begin position="87"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="12">
        <location>
            <begin position="139"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAG5099945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="172" mass="19522" checksum="52F845B7614D0E4D" modified="2022-05-25" version="1">MRFLTTRDSVDPMDEHWEYFDRDSPFSFQLGVGQVIKGWDQGLVDMCVGERRKLTIPPELGYGDRGAGNVIPGGATLLFEVELINIADAKSSANVFKEIDVDSDNQLSREEVSEYLRKQMVEANQAGDTSEEMKKIIDDHDKLVEEIFQHEDVDKNGFISHKEFSGPKHDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HHH5</accession>
    <name>A0A8J2HHH5_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="17">CYP4FP4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">HICCMSTLAB_LOCUS7800</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="2">May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 14">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Endoplasmic reticulum membrane</location>
            <topology evidence="4">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Microsome membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 15">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5095621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HHH5"/>
    <dbReference type="OrthoDB" id="7532262at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20628">
        <property type="entry name" value="CYP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050196">
        <property type="entry name" value="Cytochrome_P450_Monoox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24291:SF189">
        <property type="entry name" value="CYTOCHROME P450 4C3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24291">
        <property type="entry name" value="CYTOCHROME P450 FAMILY 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 14 15" id="KW-0349">Heme</keyword>
    <keyword evidence="11 14 15" id="KW-0408">Iron</keyword>
    <keyword evidence="13 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 14 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0492">Microsome</keyword>
    <keyword evidence="12 15" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="10 15" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="14">
        <location>
            <position position="452"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CAG5095621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="508" mass="59232" checksum="6918B0F7CE813F91" modified="2022-05-25" version="1">MDLSVLIILIVFMIALVKLIIYHYKRWDLYKAGNKIPGPRPVLPIIGNILLFMDNSDNNLNKMMSLLSNYKSSLVRIWFGQELFIYLFDPDQIKIVLHSSKSVQKERFVKFFDPWLGTGLFTAPANKWKIHRKLIMPAFHSEILVSFFDTINKKSEILVRIMESEINKNEFDIVDYISHCVLDIVCETLIGVPSNEQINGKSVYVEAFPRMMRLIYERIMTIPMHTDFIYNFTKSAREQKECIKYLHKRTHDNVEQKRRLDYKKINGKNGVLETATPKRKAFLELLIELSDKGTLSEKELYEEVDSMMVAANDTTSTVTSFVIFMLANFPDIQEKCYQELLEIQNKKTNREWRLENEDLNRMKYLETVIKETMRLFPVAPFVMRNVSDDLDIGGGYTLPKGCTAVLAFLKLHRSADYWDDPLSFDPDRFSSEQAVKRHPEAYFPFSSGLRHCPGSKYAMMSMKVIISNLLKNYVLIKDRNVDIEDIELKPDVIIRASNPLTLKIKRRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HHJ7</accession>
    <name>A0A8J2HHJ7_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Axonemal (Homo sapiens)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HICCMSTLAB_LOCUS7845</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5095712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="366230at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044458">
        <property type="term" value="P:motile cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052803">
        <property type="entry name" value="Cilium-Associated_Jouberin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44499">
        <property type="entry name" value="JOUBERIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44499:SF1">
        <property type="entry name" value="JOUBERIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="1066"/>
            <end position="1101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="624"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="734"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1582"/>
            <end position="1615"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="624"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="648"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="671"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="689"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="702"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="741"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="762"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1582"/>
            <end position="1602"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAG5095712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="1652" mass="189399" checksum="99E7CE87BFA856DD" modified="2022-05-25" version="1">MDLKLENTQFAYLKTRSQFGKWYSFSEHNKLEVDIKSDKSLMRDYIRVDPVTRTTQCSKNFSVHEVNTTTATFKEAGLHHVEGGWPKDINMYDIEQTVRYRRKVEKDELYIHTMLQLLPAMEHCILQNNACNIYEQYFNDTEAVPLVQRTFSRTVNVYRDVIPVKRPITHLSWSPDQGTRMVVSYCNRDFKKSTIHSNFSYVWDIENPNTPLMTLKPLCQIVATEYNPKDSNTLISGLISGQVASWDLRRGYEPVDVSLVENSHRDACNKVLWINSKTGTEFFSSSRDGQIKWWDTRKLQAPMDTLIIDLVKPEEQDIERATGVTTLQFESSLGTRFMCGLENGIVISGNRKGKTPSEKIATRFRAQYGPVISVLRNPTGHRELLTSGAWSTTRFSVFFLTKADGTLDVWDLLVQQDSPVLSVKVCDDSLTCVNPHEQGQLAAVAGKNGTTYLLEFSETLTVNQKNDKLLFTALIDRETRREKVIEAKNREIRLKMKSNRVEVDADGTRGSRKNSKTVDANNPAIIQCEQEYESAIEARIFRAAFRKDLSQSTQELNEEVDNNALQLNDESNKREVINKKKLILGKMKRAKALGSSDWSSDVDFGSKKNLVNEKGMEDDEIQEIVDKNENSENNMDKSARKSRKLKRSERVRSNDVESKPDIVVTFLPKQKVSDRERDSESHKKSSSREKKKRVKHSRRKNLSTGEDSTSSDIPKIPEVLAFSKEDDKLKKIKEHAKSKLKSSSSRSQSGTISSQSIDVKSPQRKNRKTRKKKEEIKREIKYISVTIHRADMLIADYVTKHPMVIVHVVEESTGSYLKTSKDSKSYLQPLITGTFDFRENKSMVPSWEEELVFEYDFDDIVNQDNHQKLILFEIVDLPSFAEASYTYDHFGGENCWYKIAWAFLKPVGANGVTHIDKFVRLQLYKPKRNSRRSIRHRCEPYSWWKSGSRDKYPSTLFVTITSVEPPKLEPIFYGQLTLDEFSDEQTEPPKSVVNTEIVNISRWSRLAAQSCKIPNELLLKTEVSDNGCFYVCFSNNGKYLACVNCEEYDYPITVWKIDDEKIFVKFSGHKSFIYALDWSHTDNYLLSVSSDQTARVWDVENKLINEINMLPHPSYVYCGKFQPSKHQIIITGCYDHVTRVWSRKNNNNNNYELIQELETHDGFVNDICFLNDGDLLTADSVGIIIQWTLKKKKGGFRDWKILRKIKIREIVNVVINTIVLHPLGSRLLVHSRDNGLRMIDLATGVVLQRYLGLKNSRVQTTARISPCGSLILCGDEDASLNIWNTDSGKHLAVYQTNLADGVITGVDYHPYDHALAYSVFGFATEACILRFNKQSTGESVGLKLLDINYQQNNHDTEIKLVDSSGRFTAPRLSHRKSYDSMKLESKENFGIMNNDSREDLRSRLKLFNDSERQFKTRSTNRLSSIIAKIDKILSNSHNQSATTRTLYDIEANGIRGFEVESPRYLDHRQEKVIPYVPPLFSTLEDNSTSGSRSEIFELTDLNNSNFNIDSRNTEKNIKCKSSRSYKRASISNNEDVDIKTMSDGAYCNRRRLKTVSERVLTGSWANIRVKDLKETRNRGKFKDSHDLELGQGDFRDQRHESSPESGGTYVLDKNDDVHIESESSVRSDVTFVIESEKPVPKPRKKSAQKLNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HIW3</accession>
    <name>A0A8J2HIW3_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Similar to Phlpp: Protein phosphatase PHLPP-like protein (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HICCMSTLAB_LOCUS8673</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5097369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HIW3"/>
    <dbReference type="OrthoDB" id="737510at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050216">
        <property type="entry name" value="LRR_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051:SF1">
        <property type="entry name" value="RAS SUPPRESSOR PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00481">
        <property type="entry name" value="PP2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00364">
        <property type="entry name" value="LRR_BAC"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="4">
        <location>
            <begin position="580"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="554"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="876"/>
            <end position="946"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="554"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="878"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="910"/>
            <end position="927"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAG5097369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="1087" mass="121278" checksum="F06ACE4AF57F39BE" modified="2022-05-25" version="1">MVLVGTLGAIMEEFDSDVMDTDSLENEATQLTGGPKKLDLCRTGLVKIPHSVLAFNAVEEILLGHNQLANPDNNLTLLKRFPSLRVVQLEYNQLRNIPRELLQLEGLTSLDLSDNKIEQVPAAIHRLVNLRELTLDRNEIKELPGEVELLKELKSISIAGNKLTDVPSFLKMRALTLDVLTKDLSKFKDEKNNQNHLHKVNLRNNQLKGNIILGNYGNLTHLDVSENSIEKLDISALQELQSARCARNSLTELTVCGRNLVSLIAGHNRLKKLTIEPTPTNLEHLDVSYNCLDALPEWISDLPVLRALFASHNDLTALPDRLLSQPSRLEVLHLPHNRLQALPPPRKPLNIVHLTLQGNALTALPTTFFQNTERLKVLNLSNNRLTELIYSEDTSKIRSVHALEKLYLTGNCLTDASLDALAKLTSLHVLHLAYNVLDTLPESCIASWPDLEELVLSGNRLQYLPDNVANLQHLRVLRVHSNRLLTCPTFNKTTSLMVLDLAHNQLDRVNLATLVPPQLQFLDISCNSRLHVDPRQFQVYRSQRPVSLIDVSGQNRASLPSHPSQQEIVSSEKGPEQPWRLGFSETAGTREKLYISQVRMPSFCNTEGLFGIFDGGVNQEAPSTLQEMIPRVLLEERTIRETSKDYLKYTLLSAHRELKEKGQKYGVDATLLHITKLPAPGGYPRSARKYCLKVAASGETKAVLCRASGPFVLAPARKPPPTNQLGNAAMFPMVVPDPVSDEVILEDDDEFVLIANRKLWEVLTMQEAVREVRAEASPVLAAKRLQDLAQAYGAEDNLSIIVIRLTPGSGDLDQLMRELRHAVTKTRNGNLPESGCACPCCVPPVPHKSPAPCCCHGNANESFYLNGVLKNIVNRSAGGQSRQGSGRYFKNTRSENASPPFRDDRSSPSGQSDQTTDSTFKSRQNSGRAWVGSTAARAAKSRNESARKDNLNTAALSEEQFRCWEYMLEQNTHMLFDKELDTLTRLPLRRGQSRSTPQLANLPFLSKRFGSARSFNPPVSRPAMIRFGSGRRFLNGGPNAAYFGSLQRLMPYNLEYDFAVIQERGLDSLEQDASRMQQYWGVATTEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HJ50</accession>
    <name>A0A8J2HJ50_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Similar to Pdcd6: Programmed cell death protein 6 (Mus musculus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HICCMSTLAB_LOCUS11364</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5103147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HJ50"/>
    <dbReference type="OrthoDB" id="186625at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048306">
        <property type="term" value="F:calcium-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd16183">
        <property type="entry name" value="EFh_PEF_ALG-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000003">
        <property type="entry name" value="Calmodulin A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051426">
        <property type="entry name" value="Peflin/Sorcin_CaBP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46212">
        <property type="entry name" value="PEFLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46212:SF9">
        <property type="entry name" value="PROGRAMMED CELL DEATH PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13202">
        <property type="entry name" value="EF-hand_5"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="6">
        <location>
            <begin position="8"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="6">
        <location>
            <begin position="88"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAG5103147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="190" mass="21909" checksum="9759117885EF955C" modified="2022-05-25" version="1">MAFQSPMPSREFLWDVFQRVDKDHSGAISAEELQQALSNGTWTPFNPETVRLMIGMFDTEKSTPDPSGMFDKSGNGTVSFDEFGALWKYVTDWQNCFRSFDRDNSGNIDRNELKTALTNFGYRLSDGLVDMLLRKYDRLGRGTIFFDDFIQCCIVLYTLTSAFRKYDADQDGVITIHYEQFLSMVFNLKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HJU3</accession>
    <name>A0A8J2HJU3_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Domeless_JAKSTATpathway_Cc</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HICCMSTLAB_LOCUS10190</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5101117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6381660at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050991">
        <property type="entry name" value="ECM_Regulatory_Proteins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46708:SF2">
        <property type="entry name" value="FIBRONECTIN TYPE-III DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46708">
        <property type="entry name" value="TENASCIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25552">
        <property type="entry name" value="LIFR_D4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="1053"/>
            <end position="1076"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="4">
        <location>
            <begin position="425"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="4">
        <location>
            <begin position="652"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="4">
        <location>
            <begin position="756"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="4">
        <location>
            <begin position="862"/>
            <end position="947"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="4">
        <location>
            <begin position="952"/>
            <end position="1047"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1132"/>
            <end position="1151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1238"/>
            <end position="1257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1405"/>
            <end position="1454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="13"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1422"/>
            <end position="1439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1440"/>
            <end position="1454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAG5101117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="1454" mass="164392" checksum="E66988817D7AD58E" modified="2022-05-25" version="1">MQYQPLDVNSSDLLKHGHDHSEKHPIMSHSDVEMYNKQLEMNSPSCKELSRLDRSVNDHPLNNNNTNNNDSINKHCDVNSRYLNNYKTDNINNNNCNATEQSRFFVCDKSYRRHLSTSDCVLNSDCVSAIERLKSTKQIMTNSRPISPTKDCRSSYCYNNYNYTYNNNINNNSTSDTPYNCYRRKSQFKWLLHAFILLFIGLISTSSADRCALGLDTPGRTWPTNDIILEYGQSLRILCILNQTIVDKEFPGKNASNLSFYRNDKKMEREYIRIINSTTIEMFVEKPPPSHDMYHCKLQTSESIKDDVAVCLNNVAVGFKPEEPKNFSCISHNWENLTCTWVPVDNFIKTTHTLTFMSSRKLFPCPKHEKEKKLPLNSCLWDFSTDPIYRQTLENYTFLMTVRNALGNMTRQYKFQHFANTIPAKPDNLTVVNKTTESALLYWAVPFPMQNFPPGLHHKIAYQHQWDRLKTWQIINITNGLHEDKKFYNLTGLEYANTVYDVRVFMKSAIAKGDDKWSPFSDITFRTPPRCEYRFVVCLMFILLIVNLPGRLPRTDIGSFEITENNANKVLYLYWQVIPRYLENGDNFKYQVTLTEVNGRKTHIMPNETTRSYAVFKGFDFFNYTFQVTTSNIVGTYPKSTSIHVPSQYDMPQQPLAVTKIAFDEGLYELSWKSPLLSNQIINYTIFWCENERDRPYQCTGYLDWVHVPKNTTIYNITVPSPEKVYQFAVSANTEKASSGMVWASCTVIHNKVSSKMKSVWINTIGSDVIDVGWKLDCSDRIGVVEGFVIYYCPIVSPKNSTCREPKQNTTIRADPLMMRSTVTGLKPYTTYKITIAFWTKTGEGLESEPLYNTTLESAPTAPQNVKVISITNSSLFVTWDPPSAMNGVLLYYEVHFNGNTQKVEDSTTNVLLKDLMSYKNYTITVTACTVKCSVESRPIIALTKIGVPGKINRPPIVKIQDSNFAIVIWSRPQNPGGRVDYYQVSAPGYIVINSNGTETKIPIPGCVENERDTTYRFKVRAININTDGEHLAGPWSDIGETSCWNAGISPRVYIIIWVICGIFALLVIAATFIYTKKMWRRCKLMQDCEVKLPPGLAAEKLLQKPGEQHIRQSSADSSGCSSVQESVTSSLTSNSHVSNDSGTETDPVSSLQNKLLDTTLVWESSSLRQRNVSGGTTRPGPGALTEARWDSYVKAGKPGERESIEREDTMSIARSTPNLRIEDSVCNVPPQTWSSTGYISMPSSEDVSTTNSSPVSVKASNISSYSVVGLLPTKMSPTRSKSSEDTSEEAKANIPYVSLASLDHKLTFISPISKEPLKSVESSKPYVQTGLIDNLKNPPFTQSEFGSKFVPKPVDRDSSMKYVTVASIAEMTKPAKDKLVQSTTDASQKPYVQASTMFQMLQAGSQEKKHEPMYWESGGDGDSKTVDVVEIEQSERSRTPQVSSSGDSQHILD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HJY7</accession>
    <name>A0A8J2HJY7_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS11907</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5104248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HJY7"/>
    <dbReference type="OrthoDB" id="8168137at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5104248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="378" mass="37313" checksum="C725D1A76AF6CDED" modified="2022-05-25" version="1">MFTEKIAINSNAYRYLLTPQRFQIETELTRFLRCCFQFRIHRNCTLDFAPEVAAEPKLGTAEPKGAGVELDPKPLKLVLAEPNAGVDEEPPKVFEAPKAGGAAADEPKEGAGAEEAPKDGVVDVEVAPKAGGADPPNAGLAPEAAPNAGVDEEPNDGVAVEAPNAGGAVVGIEPNAGGAVVDTDPNAGGAVVGTDPNAGGAVVGIEPNAGGDVVGMDPNAGGVVVGMDPNAGGDVVGMDPNAGEVAEEPNADVDDAPNAGGAVVAVVAGAAPNIDDVEPNAGVAVVVAPNAGGAVVAGAGAPNGELVDDELPNTADVFGKRGVLFCVNDVLAPPKPENPADEVEVLPNAGLATVEDPNVGALVAVAGVVLPKLAVVVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HKD6</accession>
    <name>A0A8J2HKD6_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similar to Rnaseh2c: Ribonuclease H2 subunit C (Mus musculus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS7352</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5094026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HKD6"/>
    <dbReference type="OrthoDB" id="6222486at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032299">
        <property type="term" value="C:ribonuclease H2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006401">
        <property type="term" value="P:RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09271">
        <property type="entry name" value="RNase_H2-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.680">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013924">
        <property type="entry name" value="RNase_H2_suC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47204">
        <property type="entry name" value="OS02G0168900 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47204:SF1">
        <property type="entry name" value="RIBONUCLEASE H2 SUBUNIT C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08615">
        <property type="entry name" value="RNase_H2_suC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="140"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5094026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="167" mass="19227" checksum="70596DB8DF74A783" modified="2022-05-25" version="1">MSIHLQIKKQHIDGKNNSQVHSVPCKIQRTGPANVSKYFTPYITKTDDDHFNASFRGYPLHGKKLYVPEGYKGIVFFEKKKPVNPDLKRTFNSTESFTEFTYWNWDKLPSKNDAFDAALDWVDIAESLQKTKTIIQNNQLKIVHINSLLLILGLLLLLFNESAETVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HKI5</accession>
    <name>A0A8J2HKI5_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Similar to UTP20: Small subunit processome component 20 homolog (Homo sapiens)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HICCMSTLAB_LOCUS7475</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5094970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="360653at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052575">
        <property type="entry name" value="SSU_processome_comp_20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046523">
        <property type="entry name" value="UTP20_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011430">
        <property type="entry name" value="UTP20_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17695">
        <property type="entry name" value="SMALL SUBUNIT PROCESSOME COMPONENT 20 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17695:SF11">
        <property type="entry name" value="SMALL SUBUNIT PROCESSOME COMPONENT 20 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20416">
        <property type="entry name" value="UTP20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07539">
        <property type="entry name" value="UTP20_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="U3 small nucleolar RNA-associated protein 20 N-terminal" evidence="2">
        <location>
            <begin position="840"/>
            <end position="1486"/>
        </location>
    </feature>
    <feature type="domain" description="U3 small nucleolar RNA-associated protein 20" evidence="3">
        <location>
            <begin position="1761"/>
            <end position="1977"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="798"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1657"/>
            <end position="1703"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1987"/>
            <end position="2007"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2482"/>
            <end position="2513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="799"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1666"/>
            <end position="1692"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1693"/>
            <end position="1703"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1988"/>
            <end position="2003"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="2489"/>
            <end position="2508"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG5094970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="2615" mass="300725" checksum="B9D47C7767850FE3" modified="2022-05-25" version="1" fragment="single">NEDSDDEEQVETLFYRTLLKWNMINLTEGYKKFRMEVKGVVTLKQLIEFKQKVVDSLKYHLKVNDPAYLQAILEMVVAAARDLQREFHDFIPDFLVIIIDLLNTQDPDVLEFTFINLAYLFKFMWVYFVRNIDTTFEILLPLLADKRVYINNFAAESFAFVARKITDKDKNSFLTLLFSALKKKPSGVHGCGKLLFEVVSGVPGRFNSHAEKMFNIYFQVLEDESIDSELAFGVLSKIFECVNHSINPTHSKVFWDVIFQRLDQNSKSENEKVLVPLGKLLLIVLNHRGGRMLLDPVLLTSLIIKGISIFEKKSNLVLHEFIELSVSILLAENIQLSQETSPKLISELLAISKKEILIEIIEKLVNHSSFKTRVLPLALQQDVLTKEFTNNDLNLFTKIVSVRAPPKLNGINLDKLREINLNLHKYPTDTFTILIEKLKNWEEADDISEDSLRIITILPYVNILMKQELVTVLKQVLVSMFEKLIQDESVNKIEKRTFAFLLTLESIVHLLTEEEIDHFLEESTINFETLTAKYWDNTNILNAVDLFYTHISSTKFKDKYINVQTFDSLNTHLAKKLASPYRNVRLIVCHIYYLFKDVKEIFINKSNDSSSVLEIMFMAESIEVSVQSYRDRLSHLQALSFKSRSLIELHPRYYHGPLYFLLGNFFVNFSLLWEPVSQIIATYATGEFTDFWPTFLGELQKNFGTLSSCASGLFSCEILNNLSKSLITNDKPDYNNYQTLLWTCMNKFSEYSEARNRDLTVLFINFVESNYFTSNSDKSFSIEKKDLDKTGDEVVKELEDLEDEEEETKEDSEKTDDRKIEDLPIKKMNLVKMGGKTSNLKLLLAQLKLFSQMHNPRSLYREREMYDIYMDLLKSKSMELQKAVLDCVFTYKQRELLPYKEHLYGLTDEKNLRNELARFKVVDDHAPSETIKPEDRTIVMPILMRLIYAKMVTRGTGRAAGAAGGLARRKIIVRFLMGVKEEEMMLFAEMACKPFEKYQINFFTDDQFKDIRRLTTDLTKNVDLSNIIIHPERLRSAINLLSILIEEFGGKMSKNLLPRLLAILLCALAQINGILNRSKNVLSGFLSITKELKNTCMGILGRFFEHFETYEWSQAELDALFDVAVFPWLEKLPTEGVYSPTVLLKLFSAWCQNPRYHCLLIKHQEDNQKMICLPFIMKLLLGEKTHHTVVNTILEMIKNLLTLQDYEKMEVDDADTLPIVPLNPTNILEVNAETALPGKFINYGSAILLPYVPDVLEFLKRRLLKSKMNVKKIEAAILSRISELSLNSETSNTLTLLLIPIAVKRASRGESDQIIEELLITITNLLKNVDKPQEHLKSLLPLLFYISSVSLRKNLLEIFKTIVSKETMMRNLELLVSLNAMNPRWVEQPDCEKRLETFQQINSIISSQDDEVSKTLTLEFGVAVLYNCYHFLKHETDLALRSESRWCINTLGVKLINMYKSNNVDRLYLIEDTILSLIKEGIKSKNDHIKLQSISFFGTLSMNCSDAHPVFRDLHFLTNKIDPEVDFFENLQHSQVGRRGRALLKFCSFAKTLTKPPNIKTLTQFIFPLASSFLCDETYASKNSIVDAAIEAIGTICRLLPWHQYSVILKYYLDKINKVNEFQRQVIRIIIAILDAFHFDLAKLKIVDKIIDDQKTIDPPEKETETVEEENKPEEDTVEETNEERLDEELAKDEEKVSEETKEESAELVMEKLTVLSQSAAKKLVFDITHTLLPQLNRSILSRTQHELSHKVNRKRSGYEKEEEELMRVPIALALVKLLQKLPGPILNKSLSGIFMKLCTFLKSRLESVRRSTREILEKIMITLGPDFLHHLLKEMNSLLTKGFQIHVLAYTIHAVLNSLKPYLQSNHINNNLQSILQVCKVDLFGLTSEEKEVKAIIKNVSEAKSTKSISIFRILGEFISESCLIDLVQPFYEILCSTRSHKVLMKVVESLNNISVGLADNAFIEDIKILQFIGGIVSKSIPSLTSKSEDKKSEKNKSDKPQLNKPDCYIIPAAPKSRMGIKTASKTSADANEHVITEFAMKLLHILLKRDKITGAEFKDYMDPLVPIIADNLKSQHIKLGTLSLQSINKILLMNLDSIPQHIEGICETVFSILDKYGSAGLAKGDNFELVTAAFKTMSTFVRDMKTFNMTFNQIKVLILYIEQDLYNNERRATAFSLIKAIIERKIKASEIHQVIEKVSVLSVTSDSVDVQKQCREVFYKFLMEYPLGKKLEKHLSFYLAQLSYELTPGRMSALEMIHDIINGFPEDILIKQSALIFLMVGARLVNDEDPTCCKFAAKCVKVLITRVNHNQCLKLFEIVLQWLKDSNLLHRRLAVQLCGIFVAVKKEAFETHLEELLPLILKQFYASDSENQEEGKFVLKKTRRNNQVTIKDLDRVKDHLVFQTLQLTLKISSYCQVFLKSDKYVDQVQSLAEYAQSFLAHPHLWVRLAATQQIGFVLAAIDEDKLIKIIQESKSKTVDVKKLKNEDDSEDEDDDDDDDDDDDNDKIEEKELNNTNNIKGYIYSNPIKTLRSLSLDLIAQLYPEMNVEELSDQVVKNLVFIARVIKSIPWSNDTPDKSEDTANNISIFWLLKRLKRSVNFEIRQYSKSPHVVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HL36</accession>
    <name>A0A8J2HL36_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS10476</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5101574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HL36"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035278030" evidence="2">
        <location>
            <begin position="21"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="221"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="321"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="370"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="30"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="48"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="221"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="237"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="335"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="370"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5101574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="430" mass="39385" checksum="3C49CEBA5EE3AE97" modified="2022-05-25" version="1">MATSKLSFGLLALLVLTTNAQDFRNRRFASSSSSSSSSSSSGLRDGQTYTKTDTKTTGLGRADADAGAINNDGIYFNDGNQGLHQEGFHGGAGGLDHGFGGGGGAGGAGHQYNNGGGYYGGGGHGGLGGNNNNNGGGIGGANANANANANANANAAASGIAGGAGGTGGYHGNGGLGGFGSGNNGYTGGHGGHGGYYGSGGGHKVPIYSQGGTIPTNGYTGASSGASATAGASSQTNGGGFRGPGIGGNYDQGGYNEGGSHTGGGFEHDTGFGGLGTNVLGTGNGDHGLDVGFGVGGGGHGGIGVGFTPDLGFGVVGGGHKGHGGVSGSAEGHSSAGGHGNSGGFGLTDGGHTGSTGGYGGGGGSYGIGGGHGAGSSPGGHGSSGGFGHAGSGGGTFGTGSGSAEGHSSPGGHGSSGGFGISDVTSAIVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HLJ9</accession>
    <name>A0A8J2HLJ9_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cc_odve66_13</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS10715</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5101838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HLJ9"/>
    <dbReference type="OrthoDB" id="7686319at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5101838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="259" mass="30294" checksum="4672C16B5B456A2E" modified="2022-05-25" version="1">MEDIDRKLIIGFGVIIGILVITVVIISIYSRKKDNVTIKLKDILGKLCEGQLKISDTDFKRIKIFERDRRIYLTKSSLEWKDNSGIFSEVCNFAVRLLIFYHHNPAVGIYMTVANDIVRKINDLVLQPHNYNIIRNSQGTNWIVFVNLLRLLNTFEYLADEDFLISKKICHEQILELVPGCTKLYLEESVRDEKAIYSTTARLLTNFLFNKELYKADIENNKALKILKDNFDILEKSKDKKFVCYDTYKSLYNVFRSLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HLR9</accession>
    <name>A0A8J2HLR9_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">guanylate kinase</fullName>
            <ecNumber evidence="2">2.7.4.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HICCMSTLAB_LOCUS10881</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the guanylate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.8" evidence="2"/>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5102170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HLR9"/>
    <dbReference type="OrthoDB" id="6334211at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004385">
        <property type="term" value="F:GMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00071">
        <property type="entry name" value="GMPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000776">
        <property type="entry name" value="Guanylate kinase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00328">
        <property type="entry name" value="Guanylate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008145">
        <property type="entry name" value="GK/Ca_channel_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008144">
        <property type="entry name" value="Guanylate_kin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017665">
        <property type="entry name" value="Guanylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020590">
        <property type="entry name" value="Guanylate_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03263">
        <property type="entry name" value="guanyl_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23117:SF13">
        <property type="entry name" value="GUANYLATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23117">
        <property type="entry name" value="GUANYLATE KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00625">
        <property type="entry name" value="Guanylate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00072">
        <property type="entry name" value="GuKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00856">
        <property type="entry name" value="GUANYLATE_KINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50052">
        <property type="entry name" value="GUANYLATE_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Guanylate kinase-like" evidence="7">
        <location>
            <begin position="6"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG5102170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="192" mass="21979" checksum="BB8A12CF9FEB2659" modified="2022-05-25" version="1">MLHKSPRPLVLCGPSGSGKSTLIKKLFDEFPDKFGFSVSHTTRQPRPGEEDGKHYHFISKTKMEDDISKGEFIETAVFSNNLYGTSKKAVETVINSGKICVLDIEMQGVKQIKNTSLNPLLIFIKPPSVEELERRLRARKTETEESLQRRLNTSIEEIKFGDEPGNFHRVIVNDDVEKAYRELREFILQELK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HLT2</accession>
    <name>A0A8J2HLT2_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS11244</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5102908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HLT2"/>
    <dbReference type="OrthoDB" id="7698383at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33480">
        <property type="entry name" value="SET DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33480:SF1">
        <property type="entry name" value="TYR RECOMBINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5102908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="439" mass="51477" checksum="05CF994BD0DE6385" modified="2022-05-25" version="1">MKQRKKEDGTPGLLKVGWYKKNNLRHHYRDFQDGATSSKGILTKARRIQGKIHERASKPMRHKILPYMKLTEHVKLIRYDLLIILFGNEECTKYRKRNLAQMIRAKLSLIARFLLFIKKIEVSITDFASIYDPKHYYKVIDAIHQFAELDEETGYYKIPYRASELTTNINKRGLILINECIINDDLEKKSKVENFLSLCKQGFANVVNRMVEETRIMLQRKKETELPLIADINRFSKFLDNRIDENIEVLSEKFLRRAWRDLAEACLIQLQLFNRKRAGEMDRFELDDYNKMKFITEKEEGYRSLSKEEKQKAKEYGHTVIQGKLYKSVPLLLSAKVRDGINVVIKYRKEAHISSKNPFVFGISGYYKDAHLCASNVMRKLSELCGAKKPELLRGTPLRKQMATKCSEMQLDLTQTSTILDMMYLSTRKYTSNVLKLIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HMF0</accession>
    <name>A0A8J2HMF0_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">HICCMSTLAB_LOCUS11916</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5104266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HMF0"/>
    <dbReference type="OrthoDB" id="193931at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050321">
        <property type="term" value="F:tau-protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14338">
        <property type="entry name" value="UBA_SIK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000003">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000156">
        <property type="entry name" value="Serine/threonine-protein kinase SIK3 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.80">
        <property type="entry name" value="Kinase associated domain 1, KA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028375">
        <property type="entry name" value="KA1/Ssp2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001772">
        <property type="entry name" value="KA1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057380">
        <property type="entry name" value="UBA_SIK1/2/3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF42">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE SIK3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02149">
        <property type="entry name" value="KA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23312">
        <property type="entry name" value="UBA_SIK3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103243">
        <property type="entry name" value="KA1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50032">
        <property type="entry name" value="KA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 18" id="KW-0418">Kinase</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="16">
        <location>
            <begin position="26"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="domain" description="KA1" evidence="17">
        <location>
            <begin position="879"/>
            <end position="928"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="503"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="620"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="522"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="537"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="55"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="CAG5104266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="928" mass="101635" checksum="C581A5F019A7D502" modified="2022-05-25" version="1">MASATTSHNEVSQQFFVNKLIRVGYYELEKTIGKGNFAVVKMATHVVTKSKVAIKIIDKTKLSEENLAKIFREVHIMKRLRHPHIIRLYQVMETEKMIYLVTEYAPGGEIFDHLVRNGRMFEPEARRIFKQIVLAVHYLHTHGVVHRDLKAENLLLDADNNIKLADFGFSNEYTPGMPLSTWCGSPPYAAPEIFEGKHYDGPRSDIWSLGVVLYVLVCGALPFDGPTMKSLRSVVISGKFRIPFFMSAECEKLIRHMLVVEPERRLSIRQILAHPWMGGDGVTEPEPGGCSPEPTHPPPLNQVVMENMLRLPGLRPETLLQSIQQNAFDHVSAIYHLLADRLESTMSSLPSIQNLPGDYMPDGAHQLEKFGESESEADSERAGLCLPLGTHAPYHATRRHTVGPGDTAHQPPSPYPYPYQNYTPGNYPPLGLVPMMQCNADQVLPQTNLPLNLPLVQHQPPQNFQIKDQHLLKPPPVMGASTFGRRASDGGANLHVFYQQQHGSGNAEEGGWSHPGSREHLQSSGSPSLGQCSQTLSVSGSPDSNGGSSASSSGGSDRRRRSGLTAVMQRPVINPELVMEVEARMNRAYVPSRLLPSHLRDLPPRPLHLRKTSLYPAAGVAGGRDSYKEPSAHVTTERYSPVRRASEGSCPPGPGIQALQQEYQQLQRLASPSHSPASIPGSPVHERGVAAITQGLSGLTTATVPGSIVHGTPTQAPAAPLDLSPLRHHRSPATTPVSYSPSNSPALDMIQEEHPVDISRVPPQISVTDVSGGQVTLIGCPLSPSPSLDSLEGNLPVYNPLPSFLISEPCDPSRPSITRGIGRPLSSPIPSEVEVTLSNESSRLNSEAILGRVKQIIDARAPPKGFIFSREEVEGSGLSLEYPGGVQIELRVCEFEEHEKKGIKMRRISGDQLQYSQLYEQLISCITV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HMZ8</accession>
    <name>A0A8J2HMZ8_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">procollagen-lysine 5-dioxygenase</fullName>
            <ecNumber evidence="3">1.14.11.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">HICCMSTLAB_LOCUS11999</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-lysyl-[collagen] + 2-oxoglutarate + O2 = (5R)-5-hydroxy-L-lysyl-[collagen] + succinate + CO2</text>
            <dbReference type="Rhea" id="RHEA:16569"/>
            <dbReference type="Rhea" id="RHEA-COMP:12751"/>
            <dbReference type="Rhea" id="RHEA-COMP:12752"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:133442"/>
            <dbReference type="EC" id="1.14.11.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>L-ascorbate</name>
            <dbReference type="ChEBI" id="CHEBI:38290"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.11.4" evidence="3"/>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5104432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HMZ8"/>
    <dbReference type="OrthoDB" id="69177at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031418">
        <property type="term" value="F:L-ascorbic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008475">
        <property type="term" value="F:procollagen-lysine 5-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050757">
        <property type="entry name" value="Collagen_mod_GT25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057589">
        <property type="entry name" value="GT_PLOD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006620">
        <property type="entry name" value="Pro_4_hyd_alph"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10730:SF45">
        <property type="entry name" value="PROCOLLAGEN-LYSINE,2-OXOGLUTARATE 5-DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10730">
        <property type="entry name" value="PROCOLLAGEN-LYSINE,2-OXOGLUTARATE 5-DIOXYGENASE/GLYCOSYLTRANSFERASE 25 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25342">
        <property type="entry name" value="GT_PLOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00702">
        <property type="entry name" value="P4Hc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0847">Vitamin C</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="13">
        <location>
            <begin position="517"/>
            <end position="610"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CAG5104432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="610" mass="71507" checksum="46E9EE13CC72366E" modified="2022-05-25" version="1">MDQSYNIELRFKEDEAYLQNTLYNTVPMIIHGNGPAKLVLNSLGNYLAKAWNPEEGCLNCWDNTIELSEEEQHTYPPILIAIFIDKATPFLEEFLNKIYRQTYPKSKLHLFVYNNEVNHEKLVQNWIDKFSGQYKSKKVISPSDQIDPATARDLSLNYCLLKECSGHFFIESVAHLDNEHTLKLLVEQQRSIVAPLLLRPGQSWSNFWGAVADNGYYARSSDYMEIIENKRRFLYLHLISPSRKHEWMQPDGTAKPQCQSVINLNWIIIHNQLLVGGLWNVPYIANCYLMNVTIISHAETRPVFVANELDPDMSFAITNRQKGIFMYVNNRLEFGHLVNPETYNIQYTNPDLYELFNNKIDWENRYLHVNYSNNFDEDNKPAQPCTDVYRFPIVSPRFTREFIEIMEAFGQWSDGSNQDNRLQGGYENVPTRDIHMNQVNYERQWLHFLKEYVRPLQELVFLGYFHDDDRLDSGYEPVPTRDIHMTQVGLHETWLEFLRIYVSPLQEMVFLGYYDYPPKSLMNFVVRYKPDEQPSLRPHHDSSTYTINIALNKAGVDYEGGGCRFIRYNCSVTDTKPGWMLMHPGRLTHYHEGLLVTKGTRYIMISFVDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HP15</accession>
    <name>A0A8J2HP15_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="16">CYP6JT5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">HICCMSTLAB_LOCUS10049</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Microsome membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5100976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HP15"/>
    <dbReference type="OrthoDB" id="2789670at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11056">
        <property type="entry name" value="CYP6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000042">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002402">
        <property type="entry name" value="Cyt_P450_E_grp-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050476">
        <property type="entry name" value="Insect_CytP450_Detox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24292:SF54">
        <property type="entry name" value="CYP9F3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24292">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00464">
        <property type="entry name" value="EP450II"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 13 14" id="KW-0349">Heme</keyword>
    <keyword evidence="10 13 14" id="KW-0408">Iron</keyword>
    <keyword evidence="12 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 13 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0492">Microsome</keyword>
    <keyword evidence="11 14" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="9 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="13">
        <location>
            <position position="441"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="non-terminal residue" evidence="16">
        <location>
            <position position="497"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR602402-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CAG5100976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="497" mass="56814" checksum="BACAEBADA33304F5" modified="2022-05-25" version="1" fragment="single">MEFGVQEILVIISGVLFTIYYWTVSTHNHWKRMGISGPRPSPLVGNMGSFFVGKVSIVELLDNLYNKWKNERFIGIFNGRTPVLMVMDPDLVRNILIKDFNIFPGRGMHINEADPLAQNLFAIDGHKWKVIRSKLTPIFTTGKLKQMVDLMIECVEHFEKYLKNQVGSGKVVDCREAAAKFTTDVIGSCAFGINMNALNREDSQFRIIGRKIFESSYLKLLKRLFQEATPRFCRLIGMKGMPKESIDFFVNTIRETMEFREKNNLVRHDLVDILRDIKKNENEIDFEITENLLAAQAFVFFAAGFETSSTTISFALYELALNLKAQEKLRAEILKSLKKHNGQLSYDIVNEMKYLNMVLEETLRKDSPAGLLIRKSVEPYKIPDSNITLPAGTTIQIPVYSFHHDEQYYPNPKVFDPERFNENEKRHPMVHLPFGDGPKNCIGSRFAVYQSKLGLIAVLKNFRVTPSKSTRVPFKIDSKALVLSAVEGINLTLEPLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HP18</accession>
    <name>A0A8J2HP18_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Similar to rad21: Double-strand-break repair protein rad21 homolog (Xenopus laevis)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HICCMSTLAB_LOCUS12151</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the rad21 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5106219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HP18"/>
    <dbReference type="OrthoDB" id="10071381at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008278">
        <property type="term" value="C:cohesin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990414">
        <property type="term" value="P:replication-born double-strand break repair via sister chromatid exchange"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007062">
        <property type="term" value="P:sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd21792">
        <property type="entry name" value="Rad21_Rec8_M_NXP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.580">
        <property type="entry name" value="Structural maintenance of chromosome 1. Chain E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049589">
        <property type="entry name" value="NXP1_M-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039781">
        <property type="entry name" value="Rad21/Rec8-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006909">
        <property type="entry name" value="Rad21/Rec8_C_eu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006910">
        <property type="entry name" value="Rad21_Rec8_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023093">
        <property type="entry name" value="ScpA-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12585:SF69">
        <property type="entry name" value="FI11703P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12585">
        <property type="entry name" value="SCC1 / RAD21 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04824">
        <property type="entry name" value="Rad21_Rec8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04825">
        <property type="entry name" value="Rad21_Rec8_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rad21/Rec8-like protein N-terminal" evidence="8">
        <location>
            <begin position="1"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="domain" description="Rad21/Rec8-like protein C-terminal eukaryotic" evidence="7">
        <location>
            <begin position="654"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="273"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="463"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="292"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="528"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="543"/>
            <end position="553"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAG5106219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="704" mass="77295" checksum="481C5E5CCDFFEBC3" modified="2022-05-25" version="1">MFYAHFVLAKKGPLARIWLAAHWDKKLTKAHVFETNIEKSVDGILQPKVKMALRTSGHLLLGVVRIYSRKAKYLLADCNEAFVKIKMAFRPGMVDLPEEHREAAVTAITLPEVFHDFDTAMPELKDVDIEAQFSLNQSRVEEITMREDYGNLSLVTHDQGFGDMSFDADPPELLRHGSTMEAQLDQSHMLFSDGPSIEAALEPKEKEPIAGTSTAQPMDIDTPIRDDGFGGHLGQDIISGGLFEGGLFDEAPMGEVPVPEVSNMTDQQDSVAAVPGAPSVHDDSDDMGDHFGGAPSPMGGMSSDGSRPTTPVTQVDGIAGRASVASRRFTPVPPTIPEEAAVDAIEQAPRHLEQTTLLHDEEESFALAPVDASALKGFTKAKRKRKLIVDEVKNISGEEMKAQLSDTSDIVTTLDLAPPTKRLMHWKETGGVEKLFALPARPIPARVLFKNYQRHLTSKSYDHEDFGRMAGDDDSLSLEQMRDGDVDPASFDQSSIGKRLSRKRKAPADEEPLVQPMRTPGPPPPVPMEETPMETVEPTRLSAPPPVIPPPAQSPAQSEVSLPAEPSIPLIEPSMEATEMPQIPPADVSSLLGEEPLQPADSMMENMGYDQAQPQVSYMGFDENQPPVNTPGAAHMYQVIKNKLDGKDRLTLGEMSYKNSRKQAAQKFYTLLVLKKFQVLELNQEYSYAEILVTKGPKWENPSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HP74</accession>
    <name>A0A8J2HP74_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS12171</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5106260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HP74"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5106260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="388" mass="44090" checksum="2F6F8F7A0B5C3596" modified="2022-05-25" version="1">MRDTTRYLPALTYSLFPLSRAHPYRLLLLTILQYHNHVINSLLLPLQLNLSQLTFKKFGAHVFENSKVGLRLRLLESCCAAVRDGERAWKNHLEGTAGHLASPPPCRLRGTTTAYCITFIHTTCQVKVSKWSRQLRFFNIEILRRHELDAFIGLLAHQNKWQFRAEFTSESPQVQLDLDSIRHNYSKRIPDIRSGNKSAGSQLIFFSFKSSIKRNSPSVFIILQLWFQIYHLLQSGPRTDGTSVLHLNSINHSSKLAILEDDHINALLDQSFDLLNNLIAVISDGNIDSDALAVVTNSTSFMIYISFIFPCKYFDVITDPARLSGLSRSLLESHACWRTLWEGPLLRLPRGRTENCTPAGPIFGDRCSRSPGRPTERRLSAQFLIGSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HPV2</accession>
    <name>A0A8J2HPV2_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Similar to snky: Protein sneaky (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HICCMSTLAB_LOCUS12157</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5106232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HPV2"/>
    <dbReference type="OrthoDB" id="5985669at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051856">
        <property type="entry name" value="CSR-E3_Ligase_Protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012858">
        <property type="entry name" value="DC_STAMP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058842">
        <property type="entry name" value="DCST1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21041">
        <property type="entry name" value="DENDRITIC CELL-SPECIFIC TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21041:SF17">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE DCST1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07782">
        <property type="entry name" value="DC_STAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26037">
        <property type="entry name" value="zf-RING_DCST1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="317"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="411"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="498"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="domain" description="Dendritic cell-specific transmembrane protein-like" evidence="6">
        <location>
            <begin position="353"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="domain" description="E3 ubiquitin-protein ligase DCST1-like C-terminal" evidence="7">
        <location>
            <begin position="600"/>
            <end position="644"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF26037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG5106232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="681" mass="80055" checksum="ACD3919C819964C2" modified="2022-05-25" version="1">MSIGCAVSIQIRCVCFLTLPSFLGRTGRNVLKTLTVAYIISGPVLNLSFNAKEVVRSFACTAEMHANLTKKRFDLTFEPFKQVMLGMEESKADMKVIADSVRKLMLPIVEEVEGKEAMKKFSEENDYIDEETEVNKNKEKLKPKRRKKRYKLVLDTNRIFKRNQKEETNETEETVLSAADYETKYREKIKGKCEDQLAAGSERCRYMFAKSYDQCYDAVTWAAAWLLCWPMKLDFICDAVTSLGGANICNPDGKVETGIGQGYAGLKEAQKFLEDNAKDGQLQYKVNLVNSSALVGVRDAKDSAKAILHEFTVRRDFFVSLMVIIKRLLAFIVFNIIRSAQKYHDRYLDVIDHDNRYVTKFFKKIDARRALRGSSTLLPLKKIERPKYIDPYSIKLTTRERRNLIARSLRLVFEVFTTTIFIMLDYLLYYTLFLVNKHGKIEITQSGEHNLHITVRGVGLMATLMRNIFNRFNIKRHIKVSVSNIECLPHPHKLPNYIFYKIYLTYLIIWILVFIDGYIKRLRSKMCSFFYPKREEQRIVYLYNDALRRRSHFNRFKRSRIRVLVREQLLERSVDIWFVLRNDYPRWFGWLRFFAFARPRCLLCNETEPRKKSNFHKCETPSCPFYYCKDCWNDIEEICYACTPDNFDSQDESDVLDSDEENARINARSEESYFWHHCVIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HPX0</accession>
    <name>A0A8J2HPX0_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Axonemal homolog (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HICCMSTLAB_LOCUS12729</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Dynein axonemal particle</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNAAF3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5107398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HPX0"/>
    <dbReference type="OrthoDB" id="538817at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120293">
        <property type="term" value="C:dynein axonemal particle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070286">
        <property type="term" value="P:axonemal dynein complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044458">
        <property type="term" value="P:motile cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039304">
        <property type="entry name" value="DNAAF3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028235">
        <property type="entry name" value="DNAAF3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027974">
        <property type="entry name" value="DUF4470"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031963">
        <property type="entry name" value="SAP130_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22118">
        <property type="entry name" value="DYNEIN ASSEMBLY FACTOR 3, AXONEMAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22118:SF14">
        <property type="entry name" value="DYNEIN AXONEMAL ASSEMBLY FACTOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14737">
        <property type="entry name" value="DUF4470"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14740">
        <property type="entry name" value="DUF4471"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16014">
        <property type="entry name" value="SAP130_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0970">Cilium biogenesis/degradation</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Histone deacetylase complex subunit SAP130 C-terminal" evidence="8">
        <location>
            <begin position="505"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4470" evidence="6">
        <location>
            <begin position="747"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="domain" description="Dynein assembly factor 3 C-terminal" evidence="7">
        <location>
            <begin position="872"/>
            <end position="1164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="176"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="392"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="430"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="475"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="186"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="392"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="402"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="498"/>
            <end position="509"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF14737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF14740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF16014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAG5107398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="1183" mass="131970" checksum="C83BABE9B299CCA1" modified="2022-05-25" version="1">MNTPNPGESTGDKRLPETSVQSVPHNLTTLQNVQGLQTVQTIVQSSVQTIQSTQNIVNTSTAIVGKSISLDLNQKLPLMKSVVQTAPSTSEPGKIPPNFPPVGSTLRITVPSTLTVDRQGQPQMQIQSQPQQTTQQVVTTIPATYHVPRGPAAVANISAPRSTVATPIVRASTTGPSVVPISRVGQQQQQQQQQQQQQQPIRPITTVATNRVTLTAPVGTASRITNTTPVVIQPTIGRPPNPTSGVTTASFNRVVIPSQQVQQPGQSHPPGTRVVQTITSLSNINTVSRIIAATTNPSNIARVTPSTPPSGPRITLHQLPIATTRTIPAPVKPLVAGQTIAQAVQIKSTGQPTTLRVAQANVVSTSSNISAITTAASIVTGTPASTATIIINSNNNSSHNSPTPQSVPQSSLYTQYRQGTVQPVRLIVEPSSHEENHGKPNASPRPSILRKRDHDNSPAKGAVKNLVPMLTALPLVTAPPNSSPPMSPRRERDGARDSSGSTTVSATSSPGLDEEPEQSRIPMNQTMEMSPRKKPRKQQLTGNELTEPRCSEEDMQFISEEKFKRDARDDIKDRFGMDKKQNLNSQQDRNVTTSTVIKKTRPTSSLIDPSWKNCRLNHYRRPSDVRPREERLQSVADIAQQKYVLQRLHGWKIYQLTAQMEDLAELEKQVHDKLKTTLCMLESQQPKPRQDDELERVNELIKGNMQRSHLISEGMTEARSQLVAIFEHKNAVNKIIQCFVQHSIVKMWGNSPALDFQQKNIKDNSDNKPLEVLTVGAKDPRHIIKTLASSSVNYKYLINFHVVESSLEPIARSILLLHICLEKDLGLQVASRYFLEILGNSLLVPATAKYLTKAAYQLISVITQTLPCPWISIETLKYKDKDLLEAIFKFWIRAVCEGVPIVKYWDQQIRKSLGTRYDYRDGAFDWDYHMVLKEKNIPYLTSHEYKFWRNNGIAFTWLETEPARSNPTLISSVVPYKEGFIHNAYAGDIVNGPYLTWLTDKKNEKKKLRATDAAEEQITKLFYQIRMHELCPDDLTAAHRDKAILNGTLVTEMPDINIEQESWVLKKLEKKDFSSWIDISQAKVIYHSTSSFLKYKNKCEWINKFDVIFVAHNMINHLESIVPLMNKKGIMIVESRRLLVEAKKKELEEFANELQKIANDVGIKLSETFNPHDDNFARFVIDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HPY1</accession>
    <name>A0A8J2HPY1_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS11973</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5104380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HPY1"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5104380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="105" mass="12204" checksum="4924C035C603DFB0" modified="2022-05-25" version="1">MYHHHHHHHHHHPPPPPPPSTKLVQSDDNNFHMDKIRLKKISQGSIKIADEYADALLLLVLKRWCLYMPRLSLTKAASSSYHQIIPCHLTGIIRMTITREIIRAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2023-09-13" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HQ89</accession>
    <name>A0A8J2HQ89_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS12377</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5106673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5106673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="12" mass="1427" checksum="9B955CC9DE205735" modified="2022-05-25" version="1">MKKLSLILHKTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HQB0</accession>
    <name>A0A8J2HQB0_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS13744</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5109108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HQB0"/>
    <dbReference type="OrthoDB" id="6507260at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1010">
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="238"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="30"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="239"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5109108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="528" mass="58316" checksum="FF4EB79C162DAEDC" modified="2022-05-25" version="1">MAPTPRRRGFRRNQHSIQDNAVAESQHSEASIYRISRAPSSPRPTTSRPSLREIGAKLYPVSHKSLEPHNREHTHVSDDLGTEDIVRLKPLMSVTHHPLSDKRINGNTTKPKSVSRKVIGVSVTSTVEATPYKVRVEHYDNEQLTMITRPPISGSSFAASSNLAATGIGTGTAKSGSMITTETSTWTTSTIPTPVKTSTVKTSTPIPAKLVTEELTNIVSESNRSEFSVDEGLPRTSWRARSSVTPESTITHSVPFSTSSSFPKSQEHKDSLEMATGSEPVEQSYELPDENSEIHEVQDVVHLQARKAGRHYDSPLFNQPPKVYPQPSKIYGKPSRIYGEPSKVYSEPAKVYGEPEKVYSEPSKIYIYAEPEKVYGEPAKIYSKPARVYSEPAKVYSEPAKVYSEPSKIYGLDGQPINHEPEEENYEVDEAVSVGSNGNVHGPQVVTEAPNSSAIDTSEDGHNKVGYVVEGRNYRKYRVEERTPDGFIVGEYGVVSHDDGSLRGVRYTADGTINPRLIYDALMKFLAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HR76</accession>
    <name>A0A8J2HR76_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Axonemal (Homo sapiens)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">HICCMSTLAB_LOCUS11756</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Cilium axoneme</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the dynein heavy chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5103931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="447173at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005930">
        <property type="term" value="C:axoneme"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030286">
        <property type="term" value="C:dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031514">
        <property type="term" value="C:motile cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045505">
        <property type="term" value="F:dynein intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051959">
        <property type="term" value="F:dynein light intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008569">
        <property type="term" value="F:minus-end-directed microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.920.30:FF:000002">
        <property type="entry name" value="Dynein axonemal heavy chain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.1220:FF:000001">
        <property type="entry name" value="Dynein axonemal heavy chain 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.710:FF:000004">
        <property type="entry name" value="Dynein axonemal heavy chain 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.720:FF:000007">
        <property type="entry name" value="Dynein axonemal heavy chain 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.100:FF:000004">
        <property type="entry name" value="Dynein axonemal heavy chain 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002141">
        <property type="entry name" value="Dynein heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.920.20:FF:000001">
        <property type="entry name" value="dynein heavy chain 2, axonemal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000063">
        <property type="entry name" value="dynein heavy chain 6, axonemal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002429">
        <property type="entry name" value="Dynein heavy chain, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000049">
        <property type="entry name" value="Dynein, axonemal, heavy chain 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000362">
        <property type="entry name" value="Dynein, axonemal, heavy chain 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.2620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.1220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.280">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.100">
        <property type="entry name" value="Dynein heavy chain, N-terminal domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.720">
        <property type="entry name" value="Region D6 of dynein motor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035699">
        <property type="entry name" value="AAA_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035706">
        <property type="entry name" value="AAA_9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041658">
        <property type="entry name" value="AAA_lid_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042219">
        <property type="entry name" value="AAA_lid_11_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026983">
        <property type="entry name" value="DHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041589">
        <property type="entry name" value="DNAH3_AAA_lid_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042222">
        <property type="entry name" value="Dynein_2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043157">
        <property type="entry name" value="Dynein_AAA1S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041466">
        <property type="entry name" value="Dynein_AAA5_ext"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041228">
        <property type="entry name" value="Dynein_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043160">
        <property type="entry name" value="Dynein_C_barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024743">
        <property type="entry name" value="Dynein_HC_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024317">
        <property type="entry name" value="Dynein_heavy_chain_D4_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004273">
        <property type="entry name" value="Dynein_heavy_D6_P-loop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013602">
        <property type="entry name" value="Dynein_heavy_linker"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22878:SF68">
        <property type="entry name" value="DYNEIN HEAVY CHAIN 6, AXONEMAL-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22878">
        <property type="entry name" value="DYNEIN HEAVY CHAIN 6, AXONEMAL-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12774">
        <property type="entry name" value="AAA_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12775">
        <property type="entry name" value="AAA_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12780">
        <property type="entry name" value="AAA_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12781">
        <property type="entry name" value="AAA_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17857">
        <property type="entry name" value="AAA_lid_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18198">
        <property type="entry name" value="AAA_lid_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08393">
        <property type="entry name" value="DHC_N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17852">
        <property type="entry name" value="Dynein_AAA_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18199">
        <property type="entry name" value="Dynein_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03028">
        <property type="entry name" value="Dynein_heavy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12777">
        <property type="entry name" value="MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13" id="KW-0966">Cell projection</keyword>
    <keyword evidence="10" id="KW-0969">Cilium</keyword>
    <keyword evidence="9 14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-0243">Dynein</keyword>
    <keyword evidence="4" id="KW-0493">Microtubule</keyword>
    <keyword evidence="11" id="KW-0505">Motor protein</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="16">
        <location>
            <begin position="1142"/>
            <end position="1281"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="16">
        <location>
            <begin position="1423"/>
            <end position="1559"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="16">
        <location>
            <begin position="1754"/>
            <end position="1907"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="2358"/>
            <end position="2427"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="2585"/>
            <end position="2640"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CAG5103931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="3800" mass="437065" checksum="AF5C4C540CBF1555" modified="2022-05-25" version="1">MSTKEYKCSHAGKKHKTRKEDQTEPDIVDHLKLIEEFTRNPNASFRYMIYAVERSSKYFTPYALKIVPYKQVDGAYITISGSGVTHYSPGEASFTSLSEWAREYNFYLELMKLKTFRLFSTWKAFYVWRKMLTIKKFNNAKNFIANRLFICNNTLGKALLDIKKETYNFHDTSFVDTTVVEKITLFYFVELQLKQLETSVVKLNGLRNLIIDISYDACNRSLNEVGYTIDDSNITIAQTAYGKLGTHASKIYIKNSSELKMSFIEQTRKREHCKWLSSFIHLIDYTVTSLLCNVLENTYIDLLKVLRIYTNILPNEIQFSNVQINVNRENNPYWVVDIVLTDEEIKMDPPEDVFRFVIERMQSMWRENLDIKPLLTDPHFECFTKPIINRKKENYYFGGEPPSISRILPTDTTIKTLIRELEDLLELNIIAVRRYCERFADVEEFYREDKNLNENIILNNTSCELFREWCERYKNEEEVILNITDFQPVRIFYLQLNRFKEKALLAPTEKMKLLEKIMPEIGKSKVKFLESKAFEALNYLENEPRSAEEFVDYINFVDHAQQKVDDMETEMNYIKDLYDIIEDFDVPVSIEDTTQYMGLSMQLTSLRLSIDKRLEEREKLIRGFNEKIEEDIKSLVDGISSISEQATTLKRLTKSLEDSIETAKKYQTYQRNLKLEITRLDILDQVTNQLRLRSLLWDSKVSWSEALENWYHSDFSGLDVEEMNNMVMRYTKNVTQLEKGLEENDILPTIKSQVQEMREKLPTIGYLKNQNLKKRHWMKIESLMAGKKLEADEKLTLKVIQELGVFDHEQELMEIAAAASAEAALENMLNKIQDTWKHLEFIVLGHKDSSDVFVLGSLEEIQAALEESNIAVQTIAASRHVAPIKARLDEWIKQLNLFSTTLESWQYCQQQWLYLEAIFSAPDIQRQLPLEAKLFIQVDKSWKDIMRRVAKMPLAMVFTTQPGLLEQLEDNNKSLDEITKCLEAYLDTKRLAFPRFFFLSNDELLEILAQTRNPHAVQRHLQKCFDAIYRLEFASADPEGTSRARKSSDLNELASMVRNELPKLIRDIIINLITIDVHARDIITSLVENNVTSSSNFEWTKNLRYYWDQELDNCITRMSTTEYSYGYEYLGAQKRLVITPLTDKCGAPAGPAGTGKTETTKDLAKALAIQCVVFNCSEGLDFRMMGRFFSGLATSGAWCCFDEFNRIDIEVLSVIAQQLITIRNAKVARANEFLFEGRNLKLVMSCATFITMNPGYAGRTELPDNLKSLFRPIAMMVPDYKLIAEVILYSEGFESSKQLSKKMTLMYTLCSEQLSQQDHYDFGMRAVKSVLVMAGSLKRENPDKSEELVLIKALRDSNLPKFLADDKLLFLAILADLFPGVDIPEDHYGVFQDTIIDILNAANLQPEESSINKTIQLHETIRVRHGVMLVGPTGGGKTTILRTLSEAYTTLAEKQIPGQLNRRVNMYTLNPKAITMSELYGEVDIYSNEWHDGLLGAIIRKACSSEADDHQWVVCDGPVDALWIENMNTVLDDNKMLCLANSERIKFTPYVRMIFEVMDLCQASPATVSRCGMVYVDPLELGWMPYVKTWLIGFKSKFKESPSLGNLIAGIVLALFDRYVDISKVNTVCTLLESILLESDTVNKIVDKSRLTTFVTQSFVFSYIWGIGGNVIDSSREAFELFVTHQLEGNSSARLPVAGDLWNLWVNTDKQRMDIWLKMIPAFTYDPQVPFFDILVPTIDTVRFEFIVKKIINANKSVFITGATGVGKSVIMKGVLKSLRESEQWLPITLNFSGQTTSKQTQDILELKMEKKMRFSLGGPVGKRVCVFVDDVNMPRLDTYGSQPPVELLRQVLDFRGFYDRKKLIWTSIEDVVLTAACAPPGGGRNPLSQRFIRHFAMLMIPIPTEASLQTIFKAIVRGFLSHKLFPQSVVNIADAIVTAAVEIYDRIATDLLPTPAKSHYIFNLRDLSKCVQGMMQSDPVSIRDARQMTRLFYHECLRVFHDRLVDNIDKSYFYRLLSETCSGFFPDQVVALPENTSDSIDTPSELFFGDFMKFGTPRELRIYEEVTDVEKIKSVLQFKLEGIDFKTSQDYLDDYCLATKKDLKLIFFFHAIEHLCRIARILRSERGHGLLVGVGGMGKQSLSKLASHLNGYPCWQIEISRGYDINSWHTDLRNFYSKPGALAEDATFLFTDTQIVMEEFLEDINNTLNSGEVPNLFEADELEKIIILTRPAAKEAGLSEENRDEIYNLFVSRVRNHLHIVLCMSPAGDAFRRRCRMFPSLVNCCTIDWFTKWPDEALLSVAKISIVPDITQDLQLASSLASICMLMHQTTDKMTERYLTEMRRRYYTTPSSYLELLKLYSTTLKRKTDEIMSLKNKIENGLNKLYETKETVDVMKNEIIILTPQLKTSREEVEKLMEVVTKEKIECDKVRSVVEADEATAKIKADEMAVLEIEARKDLEAAMPALEEAQKALQSLNKSDINEIKVFNKPPHLVRYVMEAVCLLLGEKTDWPTAKLILSDVHFLDRLINYPKDDINDKLLKKLESYLKNPEFVPDLVAKQSKVCKSICIWVRAIDGYAKVFRVVEPKRLKLQQAQEELQALKELVAEKQKQLSVVVKKIEKLEKQYNLAVKRLDQLESTIALNESRLNRSGRLIAALSDGQELWQDMTRGFHSKINNLTGDCLIIAGALAYFGAFTQIYRQELLRVWLTAIDTHKINITENFSLVKSLISPYKICTWNVFGLPKDNVSTENALLGYRWIRNMEAENNIKISEMNNPNLMRIIENCIRLGLPVMIYNVGEILDPSLEPILLQQIFMQEGRMIMRINNTDIEYEKGFKLYMTTKLSNPHYLPEVCIKVTIVNFTVTPSGLEDQLLGEVVKLERPDLEKQREELVEKINHDGIQLEKIEEKILSMLSSPGNILDNEELVESLNNSKETSAIITARLVESEKTEAKIIIARDKYRSVATLGFILFFVIASLAEIDPMYQFSLKYFKQVFNHAIETSEKNQDIEKRLSILNEKITLAIYLNVSRGLFERHKIILAFMIDVAICINNKTVTQTQWNFILRGPGSIELRKKPENISDLAWKSINYLDKNFSVFNGIIDDAFRKIKLTLGYIEEEINLKRNNNIEAIKDWNILLSDIEKLMLVKSLKEEKLLVLITALVNKDFGRKFIESSIVTLSDTYQDISHNTPLIFILSTGCDPFGSFIKFAGEMGFIDKYSSISLGQGQGPIAEKLIKDGRVKGHWIFLQNCHLATSWMPTLEKLVSEITDESVEVHRDFRLFLSSMPSDAFPISILENSVKITNEPPKGLKANIKRMLFDLSQEFFEHDGDNWRVMIFGICFFHSIIQERKKYGPLGWNILYEFTDNDRECCLSNLKIFTENELIPWNALVYTTGEITYGGRITDNWDLRCLKTILDNFFSPKIFNKDYIYSPSGVYYCPRLKTLEEYKNFVETFPIIDEPEIFGMHENANITYQLRESQLVINTIAQIQPTVDANIESKSNSEIVYDTAQIIMNQIELNIDSDKCNKNHYKKDSAGRVPSLTTVLLHEIDRYNKLLKNIHASMENLQRAIKGFVVMSDELENVFNSLLNNQVPKVWHDLNVYPSLKSLGSWIRDLELRTDFIKVPKNKIFYFNYSIKMNLINFLTDILIQSWLTNEPVSYWLSGLSFPQGFITAVLQTHARKYNIPIDQLKLDYAVTKTLLYQDEIQNAHTINQQDHLLYKNLSMPSDGVLIHGLYLDAAKWNINSMLLVDASLGEINPPLPVTHVIPVLTHPENDQRYICPLYKTAVRAGVLSTTGHIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HS84</accession>
    <name>A0A8J2HS84_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS13732</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5109096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HS84"/>
    <dbReference type="OrthoDB" id="565904at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00301">
        <property type="entry name" value="lipocalin_FABP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012674">
        <property type="entry name" value="Calycin"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50814">
        <property type="entry name" value="Lipocalins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5109096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="109" mass="12508" checksum="11C4192812361FF1" modified="2022-05-25" version="1">MSSGAVSDWSVTGTPIGNISVPQYRVNVSDQAIANNSVVTILDTDYTGFTMLYMCRQVNEIHLINLWLLSRDRRLSFRTWRRRWWDAFSNGLPIGVMRGVRQRNCPVSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HSH9</accession>
    <name>A0A8J2HSH9_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similar to Hemolymph lipopolysaccharide-binding protein (Periplaneta americana)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS12483</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5106884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HSH9"/>
    <dbReference type="OrthoDB" id="7357196at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00037">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050801">
        <property type="entry name" value="Ca-Dep_Lectins_ImmuneDev"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22801:SF63">
        <property type="entry name" value="C-TYPE LECTIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22801">
        <property type="entry name" value="LITHOSTATHINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C-type lectin" evidence="1">
        <location>
            <begin position="19"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5106884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="151" mass="17315" checksum="E43C6C0BB4573A2E" modified="2022-05-25" version="1">MSCCDLLEDYQYFQGIGTYKLHTRGATFFRARQICKEEGGHLAIINSLAEEKVLLDLFKRPEKFVNVMSNERALLGIHDIFAEGEWETIFGQSLYRTGFSKWSNNWNGQPDDSKHILNCGFLLKSGGLDDDLCDAQHPFFCEIPEYCVAYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HU89</accession>
    <name>A0A8J2HU89_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS13725</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5109089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HU89"/>
    <dbReference type="OrthoDB" id="565904at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012674">
        <property type="entry name" value="Calycin"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50814">
        <property type="entry name" value="Lipocalins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035298293" evidence="1">
        <location>
            <begin position="24"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5109089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="144" mass="16593" checksum="01A25E2F113CBAC8" modified="2022-05-25" version="1">MLEFKNKIIFFLIFEIHILMAEAVDCQKPQVELLDLDRYAGTWYTYERSCGDCTNLTKCSRASWSKPDQNGNSTVIISEFSEISFSLSEVTSKAYIEDNKIINEICVPAVGTVRLEFWILATDYDTYSIVYSCKVDRDKPCVRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HUB4</accession>
    <name>A0A8J2HUB4_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">L-2-hydroxyglutarate dehydrogenase, mitochondrial</fullName>
            <ecNumber evidence="7">1.1.99.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HICCMSTLAB_LOCUS13786</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>(S)-2-hydroxyglutarate + A = 2-oxoglutarate + AH2</text>
            <dbReference type="Rhea" id="RHEA:21252"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:16782"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="EC" id="1.1.99.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the L2HGDH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.99.2" evidence="7"/>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5109150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HUB4"/>
    <dbReference type="OrthoDB" id="498204at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047545">
        <property type="term" value="F:(S)-2-hydroxyglutarate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43104">
        <property type="entry name" value="L-2-HYDROXYGLUTARATE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43104:SF2">
        <property type="entry name" value="L-2-HYDROXYGLUTARATE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="9">
        <location>
            <begin position="33"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00036066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00041137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAG5109150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="367" mass="40766" checksum="F68BAC6334F76079" modified="2022-05-25" version="1">MSSGIIKLGRTIRHLGITCRYASTSSADHDTYDLVVVGGGIVGCATAREMLERHPNMKIVIVEKENKLAMHQTGHNSGVIHAGIYYTPGSIKAKLCVEGLKLSYDYFGKHNIPYKKVGKLIVAQDQEQAKRIDDLYQRGLKNNFEKMGGKVILNYEVTGFAENAESQDHKKFLPICVMSKNKMIHTKYVLTCAGLHSDRLAVMTGCDFSPRIIPFRGEYLLLDENKKHLCKTNIYPVPDPSLPFLGVHFTPRINGDIWLGPNAVLALAREGYRFVILSTWTDINIRDCIEMAKSPGLYKLCFRGPAGVRAQAMDDDGKLVDDFVFDNGVGSIGSRVLHCRNAPSPAATSSMAIAKHICNKLEKDFKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HUJ3</accession>
    <name>A0A8J2HUJ3_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS13953</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5109317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HUJ3"/>
    <dbReference type="OrthoDB" id="7667486at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5109317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="122" mass="13688" checksum="42EFAAF1C7560F90" modified="2022-05-25" version="1">MTKIGNSVYCRNAIYDSATGASKKATYIARRLLKGIFTHESLMNCTLTGQAPRGKHTKSDVEIIPLNKRGRDAILDFAIRYTAAKNWPKQDSAVILMEMGQRITEYKRNHNNAIVKSAKKDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MAT6</accession>
    <name>A0A8J2MAT6_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to HDAC1: Histone deacetylase HDAC1 (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS2999</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001117">
        <property type="protein sequence ID" value="CAG5079390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MAT6"/>
    <dbReference type="OrthoDB" id="1918432at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004867">
        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.22.10">
        <property type="entry name" value="Antistasin, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004094">
        <property type="entry name" value="Antistasin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011061">
        <property type="entry name" value="Hirudin/antistatin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02822">
        <property type="entry name" value="Antistasin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57262">
        <property type="entry name" value="Leech antihemostatic proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Antistasin-like" evidence="2">
        <location>
            <begin position="24"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="138"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5079390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="161" mass="18016" checksum="3D6AC06043DD9E1F" modified="2022-05-25" version="1" fragment="single">MGPAAAVNCNQVTDKSKGRALPTSCSLYHYAQVCQYGFKVDEAGCSTCKCNNPCEGLFENLRMLPHAPEVQVQAIPENGANINDSEVEEKVNLDERLPQRDIDKRIQHENEYSDREDEGEGGSRDNRSFKGSRKRPRLEKEQEPMETDIEKADDIKNGANG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MCH3</accession>
    <name>A0A8J2MCH3_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS3181</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5081052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MCH3"/>
    <dbReference type="OrthoDB" id="10051804at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33964:SF9">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33964">
        <property type="entry name" value="RE45066P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035243098" evidence="2">
        <location>
            <begin position="22"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="154"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="172"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5081052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="234" mass="26176" checksum="D64346C96951DA62" modified="2022-05-25" version="1">MYSQLVLFALILVSGASVISSYGCGREDHQKCITLADPLLKDPHLIFPDNMEDIDLVCRSWAGFVDCIKRYIDRCFSKQRRDQFNAAVEAPISSVHQMCSVSTYQAEYLQHASCLKATVTEPQHCGNEYSALVNEVSRGEMARANLCCSIDESSSISSSRGVSRRPYHRTLSPDSYSGQASSFHGASTSAMNGPTPYRSTGRSLNVLPSKTIFYSNRIKKKYIYIYIYIYANLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MIE5</accession>
    <name>A0A8J2MIE5_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS4507</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5087413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MIE5"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5087413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="63" mass="7472" checksum="ED67E7539BFAD29D" modified="2022-05-25" version="1">MFIINLLILYFFVLAGLSVEFKIFGYILPKLLLKFINLLLLQLLNYMYLLCDTEDNIRTENLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MIF5</accession>
    <name>A0A8J2MIF5_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to SRRD: SRR1-like protein (Homo sapiens)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS4536</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SRR1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5087533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MIF5"/>
    <dbReference type="OrthoDB" id="551431at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012942">
        <property type="entry name" value="SRR1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040044">
        <property type="entry name" value="SRR1L"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28626">
        <property type="entry name" value="SRR1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28626:SF3">
        <property type="entry name" value="SRR1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07985">
        <property type="entry name" value="SRR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SRR1-like" evidence="2">
        <location>
            <begin position="72"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5087533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="277" mass="31188" checksum="25AC9023F1E431C2" modified="2022-05-25" version="1">MPGLDEFQVVRRRRPGRRRRIIPLLPGEVLDAPEINTEQLIRSILDAVIVLRNSPYRQTLYDGLSETLSILDRDAIPEIVCYGLGNFSQCRSSKHQLAALLTIKSRYKSQVFIYDPVFYPQELEVLKILGLSIIPNNEQAVRPVNDDTLTLFYMPHLFKGLIANCIYANWGADLNNCILVTNSFKTMVDDFNSGIGLDAVDDPGYPEALQLIKKAATLAHEIVLDESFDDDQHYMANAFNSTSIHLFTKSRLDAVSGDFWAALPGLPYRPDDAGREL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MK12</accession>
    <name>A0A8J2MK12_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS5731</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5090738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MK12"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="22"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5090738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="143" mass="16290" checksum="7B44C24718290E78" modified="2022-05-25" version="1" fragment="single">YCVYLSSQQAMDEQQSKDMNKENNGNTGNMTEENNPHKDFETNEDSLVNTKDSIDGTETKATQKNDKNPKIFHNSKLVEKSMTQLAIPNTDKLDNETQIMNDSLKKMSGNNSNSQIMKSPKKSFAVKRSRDDKKKNIKNIVKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MK97</accession>
    <name>A0A8J2MK97_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Similar to exosc6: Exosome complex component MTR3 (Danio rerio)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HICCMSTLAB_LOCUS3386</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RNase PH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5081819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MK97"/>
    <dbReference type="OrthoDB" id="2504340at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000177">
        <property type="term" value="C:cytoplasmic exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071028">
        <property type="term" value="P:nuclear mRNA surveillance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071051">
        <property type="term" value="P:poly(A)-dependent snoRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016075">
        <property type="term" value="P:rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034475">
        <property type="term" value="P:U4 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.70">
        <property type="entry name" value="GHMP Kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001247">
        <property type="entry name" value="ExoRNase_PH_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036345">
        <property type="entry name" value="ExoRNase_PH_dom2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027408">
        <property type="entry name" value="PNPase/RNase_PH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050080">
        <property type="entry name" value="RNase_PH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11953">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11953:SF2">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT MTR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01138">
        <property type="entry name" value="RNase_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55666">
        <property type="entry name" value="Ribonuclease PH domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0271">Exosome</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="Exoribonuclease phosphorolytic" evidence="9">
        <location>
            <begin position="46"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAG5081819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="233" mass="26480" checksum="349A4A838F4F8541" modified="2022-05-25" version="1">MPVDQRRINGPEVTVPYQIYVDSTSSKTENPEKFLKNRKDGRQNQELRKIFIKTGVVSQAKGSAYIELGKTKVICSVFDPRDVPNKSGYSCHGNLYCEFKFASFSCAKRRIHQQDAEEKEFSLIMQRSLEPAVCRGIYADTVFLDPTTDEEELCMSVPSKTHKSKNHGIIMQASLLQKNQVSEFYFVGNINLDAMQSTMEALTKASENLSLVTQQYLVKLALKKHKNNIKNLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MLI2</accession>
    <name>A0A8J2MLI2_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similar to Tgfbi: Transforming growth factor-beta-induced protein ig-h3 (Mus musculus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS6346</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5092739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MLI2"/>
    <dbReference type="OrthoDB" id="286301at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050839">
        <property type="term" value="F:cell adhesion molecule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030198">
        <property type="term" value="P:extracellular matrix organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.180.10">
        <property type="entry name" value="FAS1 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050904">
        <property type="entry name" value="Adhesion/Biosynth-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036378">
        <property type="entry name" value="FAS1_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000782">
        <property type="entry name" value="FAS1_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10900:SF120">
        <property type="entry name" value="MUCIN-5AC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10900">
        <property type="entry name" value="PERIOSTIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02469">
        <property type="entry name" value="Fasciclin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00554">
        <property type="entry name" value="FAS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82153">
        <property type="entry name" value="FAS1 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50213">
        <property type="entry name" value="FAS1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAS1" evidence="1">
        <location>
            <begin position="79"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="FAS1" evidence="1">
        <location>
            <begin position="233"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5092739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="342" mass="37675" checksum="10BF606AF49B955F" modified="2022-05-25" version="1">MAPVNEIITTPSSTFLPHSSSYVHFSTNLGNPATTATPRSVTSTIGSINNVASENLIIDDFHQGRNTINFDNTINQFNSGETIANLLKREGLFAMAKYLRQSGLDKVLNDTGPFTIFIPTDKAFRALLVQLGGPEKAEQKFKENPRLLSGLLLHHVIPGDFKTESLQEEMTGVSLAGTQLRVNVYDMHDHEWNDVKVTTINGARIAPNKRDIEIPQGIAHAVDRVMFPLPVGDLLQTLAADREQRFGIFLRILQAAGFEDILTGTKTYTIFAPTDAAFAATAAQTGQPVWSETDGPEAAKTIASKHIMPTTLYSAGMRYYHQKDTLRPQFTLRIQKNGGYTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MLR9</accession>
    <name>A0A8J2MLR9_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Similar to Tret1: Facilitated trehalose transporter Tret1 (Culex quinquefasciatus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HICCMSTLAB_LOCUS6436</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5092917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MLR9"/>
    <dbReference type="OrthoDB" id="6612291at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000249">
        <property type="entry name" value="facilitated trehalose transporter Tret1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050549">
        <property type="entry name" value="MFS_Trehalose_Transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48021">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48021:SF24">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="30"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="55"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="82"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="115"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="141"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="240"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="302"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="337"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="1"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="415"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="416"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAG5092917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="447" mass="49626" checksum="5F6091BFA48ADA3A" modified="2022-05-25" version="1">MKESASRMLLYPLEVLTKAMSNGRNSRMQYLSIIVVAVPIGSLIVGFLMEAFGRIRTLQLGAIPCIIGWILIATAQNIPMILVGRLLTGLAIATSTSPSIVYITEVATPDLRGSLMSFGPTLASLGMLLSYLKGAYLPWRLVAWLATIYAVVPLFLVQFFVPESPVWLVSKGRIDDAKKSLARIYKSEEKGFGKMSPAEQAFTTIMKENEIKLSEQRRSKRGSLSTKLRAFLKPTGWKPMIILIIFFLFQQFSGIYITLFYAVTWFQEVKSGVNEYTASILVGLTRFLCSMVNTWLLRRYKRRPLCIISALGMAVCMSVSGYFTLQIKNGSESGNWVPVLGLLLYVCTSMIGMLTIPWTMTAELFGSEIRGVAQSVSYAMANVLMFAAVQSYRDLSTLLGEYFYNNTIAAGADAKARRRRAKRRAEQKAQAQASVPLNPTPKNAEPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MMF8</accession>
    <name>A0A8J2MMF8_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Similar to Npc2a: NPC intracellular cholesterol transporter 2 homolog a (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HICCMSTLAB_LOCUS7999</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NPC2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5096017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MMF8"/>
    <dbReference type="OrthoDB" id="4937502at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032934">
        <property type="term" value="F:sterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032367">
        <property type="term" value="P:intracellular cholesterol transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00916">
        <property type="entry name" value="Npc2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.770:FF:000001">
        <property type="entry name" value="NPC intracellular cholesterol transporter 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003172">
        <property type="entry name" value="ML_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033916">
        <property type="entry name" value="ML_Npc2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039670">
        <property type="entry name" value="NPC2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11306">
        <property type="entry name" value="NIEMANN PICK TYPE C2 PROTEIN NPC2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11306:SF36">
        <property type="entry name" value="NIEMANN-PICK TYPE C-2C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02221">
        <property type="entry name" value="E1_DerP2_DerF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00737">
        <property type="entry name" value="ML"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035295355" evidence="6">
        <location>
            <begin position="19"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="MD-2-related lipid-recognition" evidence="7">
        <location>
            <begin position="20"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG5096017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="148" mass="16297" checksum="D7918C2A5F5BCABE" modified="2022-05-25" version="1">MYRITLGLVLYLAVSANAVFQNCGSKIGSYISVNVSNCDPDASICTLTRGKDVSINIKFELDKDIERVNSVVHGVIGGAPLPFPIAHPNACEASGLKCPMTKDGGPYEYKTNLHVESYFPKLKVDVKWELKDEFYNNIICVLIPSQLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MN77</accession>
    <name>A0A8J2MN77_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS9497</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5100325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MN77"/>
    <dbReference type="OrthoDB" id="7696071at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5100325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="327" mass="37617" checksum="2686E8572784610A" modified="2022-05-25" version="1">MEASPVKLRSNRAAESTKLTLNESPYWEYILREFVFKTISSLPQSNNVLYKKLLEAPFYGGPLLTLSNEDNTLLSRGDVYHLPNGQWILCQEGCENCKLCSNQKDSLVKWELKKVKPNTSSDLYKYDLQLTVIPQRGSTALSNFGIENIYIPYGIKSSTESSKSDSLVTEHSHIDRTRFSRSWRRMQRDQIGQLDKDSTNINQTEELLSLDNSTTDSQLIPRDDIGDSHDTSPAHRLILGADQLGNKHVIHILSLNSSSSEKLNFYNDVDYQLMNNAEKLSKLYSDVRKLSPYQRYLEKILDSIHNHRPFVETFLSYDQLNQNKRDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MNA5</accession>
    <name>A0A8J2MNA5_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS8301</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5096621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MNA5"/>
    <dbReference type="OrthoDB" id="7483346at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5096621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="344" mass="39937" checksum="D51DF314370FF9A0" modified="2022-05-25" version="1">MNNLLHDHICRVIEAVAPLREVEVRDQPAPWVTQDIRILQRRRSKLYRIFKRSRFAYKEYSGMRKFIKRRIADAKKEYFDNRLSNLVKRLDVRAAPDLNLDEMNAYFVTAAGSPLQNIDFEYLEARIVKHSNSFELKELTSVNVRQTCMMLTSGSVGPDHFEIKTYKVLLPYFLSHITNLFNFSLSSEWCVKNGLNMNRGKMKAMIFGTVFKLADLQHVPVPNTIINNTVIGYCKSVKYLGVVLEDTLTWSLQVNEICKSTMRILAQLKMNDAFSFPVRCQLRRGDVRNDSLVVPGCYSTKYDEFFLVSAIRVWNRLPSYCTAQPTFPTFRKACYEFLLSEENG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MNN7</accession>
    <name>A0A8J2MNN7_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Similar to UHRF2: E3 ubiquitin-protein ligase UHRF2 (Homo sapiens)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HICCMSTLAB_LOCUS8983</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5097999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MNN7"/>
    <dbReference type="OrthoDB" id="2270193at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044027">
        <property type="term" value="P:negative regulation of gene expression via chromosomal CpG island methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.280.10">
        <property type="entry name" value="SRA-YDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036987">
        <property type="entry name" value="SRA-YDG_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003105">
        <property type="entry name" value="SRA_YDG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045134">
        <property type="entry name" value="UHRF1/2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14140">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE UHRF-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14140:SF27">
        <property type="entry name" value="OS04G0289800 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02182">
        <property type="entry name" value="SAD_SRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00466">
        <property type="entry name" value="SRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51015">
        <property type="entry name" value="YDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YDG" evidence="4">
        <location>
            <begin position="74"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="444"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="636"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="788"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="449"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="648"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="805"/>
            <end position="819"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAG5097999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="832" mass="95360" checksum="E5678F809E79FA85" modified="2022-05-25" version="1">MAKNALNVNFYPNTLKDNDAILRKLRSRSKIDNKTQEEWSKLFTKLNTESKKQTNKTSDVRQSHIGNSEDVTYGVIEGFPSGSWWGIRMDCARDRVHKSFDNDIDEGIFGVASICTSHVNTTNDVDLGTYLTFTGGKYNQSKPTDPLLTNFNNHIPLRLIRSYNLANEFAPKTGYRYDGLYIVASCWIGINSKDSTRYYKYALARLNHQEAPPWVTQTRIVTRQSSSQKSPLKSCGLYKCHMYGCSQESKKLKSCESDVEKVKLNADLGEKEKEAEKEASLLNSLNFISKPYKLQNTNISIRTELYDSSPNPQQDVKKTPMTYCRVYNKTKSESKKLDVDLKKIQEDKNLFLDSRASTRASVGSESSGLSEKKVDLQKAVVEIETMTPEQMLNLIIKKRYNPTGKLLIGSIIGLPENEGKNLNSGKVKSNIDHFRETRSTVKNQEVKTNLKRSKNKSKKSVPRKRRNELANLTIDANFGMNLRGQCIQTRTMKNRRLRCPAIILSKRKDLSDYITSYPRVELRRKGKIIATAKKSQIGVCKRHTIVKNKEAERKHEIQGNLRDRNICNINKNINNNNILKRRNKIINTESSLIKPRMVDASTQCITTKDATTFVNMETQKKNEESFVKIEVIDLEDEEEMEEVKSEFEDSNSEEEEEEEEEEEESLRDKKFYSGNDVDININNDDNDNLSAFVALSDRDMRVARLRSIGFKPIEPVIVSENGSFVQYYNCDASTSSLNAVVERQVDEQYNKYTSEENNVVEYMDHELHFQDVEEDGIKHDCKNSGGNFDNKGGCKSEKKRRCSSSEEEFQSENFDEEQEAPWLGWSRSTANR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MP40</accession>
    <name>A0A8J2MP40_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Glutathione peroxidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HICCMSTLAB_LOCUS10420</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the glutathione peroxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5101347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MP40"/>
    <dbReference type="OrthoDB" id="446890at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00340">
        <property type="entry name" value="GSH_Peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000025">
        <property type="entry name" value="Glutathione peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000889">
        <property type="entry name" value="Glutathione_peroxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029759">
        <property type="entry name" value="GPX_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029760">
        <property type="entry name" value="GPX_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11592">
        <property type="entry name" value="GLUTATHIONE PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11592:SF134">
        <property type="entry name" value="PHOSPHOLIPID HYDROPEROXIDE GLUTATHIONE PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00255">
        <property type="entry name" value="GSHPx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000303">
        <property type="entry name" value="Glutathion_perox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01011">
        <property type="entry name" value="GLUTPROXDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00460">
        <property type="entry name" value="GLUTATHIONE_PEROXID_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00763">
        <property type="entry name" value="GLUTATHIONE_PEROXID_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51355">
        <property type="entry name" value="GLUTATHIONE_PEROXID_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 6 8" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0712">Selenocysteine</keyword>
    <feature type="domain" description="Thioredoxin" evidence="7">
        <location>
            <begin position="28"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000303-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG5101347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="189" mass="21505" checksum="92FE4CC838EBA135" modified="2022-05-25" version="1">MRFLKYPIIPVGLQQIRNLAVMSGNLDYKSAKSVHDFEAKSIKGEDVPLEKYKGHVLLIVNVASKCGLTATNYKELNELYDQFAESHGLRILAFPCNQFNGQEPGDSDEICSFADRQKVKFDLFEKIDVNGETTHPLWKYLKKEKGGTLGNFIKWNFTKFIVDKDGKVVERHGPNVDPSSLAKNLEKYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MP83</accession>
    <name>A0A8J2MP83_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS7682</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5095384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MP83"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5095384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="155" mass="16868" checksum="969F0FB768813677" modified="2022-05-25" version="1" fragment="single">SQQVLIKTFQAHQNTRRNSPHHLANDAAAYLQESVCGVTKSTSSTTRLRGVVKSITSGVILRCGELDFVVTGSVLSKEGLEASWCFNNDAVELAVDQELSSRTAKFSITSCLPISISCVNTWNRRAFSSTSPLTNDSLLEATNFGNKNFPLSDPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MPY7</accession>
    <name>A0A8J2MPY7_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to BTBD19: BTB/POZ domain-containing protein 19 (Homo sapiens)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS11100</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5102608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MPY7"/>
    <dbReference type="OrthoDB" id="25620at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011705">
        <property type="entry name" value="BACK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051481">
        <property type="entry name" value="BTB-POZ/Galectin-3-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006571">
        <property type="entry name" value="TLDc_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24410">
        <property type="entry name" value="HL07962P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24410:SF34">
        <property type="entry name" value="LD40565P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07707">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07534">
        <property type="entry name" value="TLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00875">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00584">
        <property type="entry name" value="TLDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51886">
        <property type="entry name" value="TLDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="42"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="TLDc" evidence="2">
        <location>
            <begin position="290"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5102608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="472" mass="52330" checksum="FE86ACCC8A4A3E92" modified="2022-05-25" version="1">MGTRAVGLGSAGGAGVVGEAGLAGVPRLLEDLTRLSEDNESADIVFLLGRDETPVYGHRIILQVRCKNFTTPKRMGTSGNPTPIRMPHAHPETFRQFIHYVYTGKIMLQDSGIFEMLALAQELGVEELWRSCEEHVSATLSPGNACALLTAALDAQDRVLVKTPAFSNLPKDALVKLISSDYLGLEEEDVWRAVLNWAKYQAGVTQPTQHWTEEERARVCQHLAGVINHVRLLLIDSHVFAEEVEPTGAVPIELSLERYRYAAVPNKYSEICADKRLQPRIGPLLFPGSQILSRDKMGYQRLLNQWYGNPKQNWRLIYRASSNGYSASAFHRHCDGVAPTYTIALSSRGEICGGFSDVAWDKTSAKGHYISAEKAFLFTLTNNQDVPPTKYDLIKKPFAICYHPDIGPIFGAGADLLISNNCNVNLESYSNLPHTYDGENASSTILMGDYHFTVLDYEVFTLNGPISKSERH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MR23</accession>
    <name>A0A8J2MR23_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Similar to neurl4: Neuralized-like protein 4 (Xenopus tropicalis)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HICCMSTLAB_LOCUS11828</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5104090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="49113at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12887">
        <property type="entry name" value="SPRY_NHR_like"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.920:FF:000001">
        <property type="entry name" value="neuralized-like protein 4 isoform X1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.920:FF:000014">
        <property type="entry name" value="neuralized-like protein 4 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037962">
        <property type="entry name" value="Neuralized"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006573">
        <property type="entry name" value="NHR_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12429">
        <property type="entry name" value="NEURALIZED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12429:SF14">
        <property type="entry name" value="NEURALIZED-LIKE PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07177">
        <property type="entry name" value="Neuralized"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00588">
        <property type="entry name" value="NEUZ"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51065">
        <property type="entry name" value="NHR"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NHR" evidence="3">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="domain" description="NHR" evidence="3">
        <location>
            <begin position="191"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="domain" description="NHR" evidence="3">
        <location>
            <begin position="388"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="domain" description="NHR" evidence="3">
        <location>
            <begin position="575"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="domain" description="NHR" evidence="3">
        <location>
            <begin position="775"/>
            <end position="942"/>
        </location>
    </feature>
    <feature type="domain" description="NHR" evidence="3">
        <location>
            <begin position="1011"/>
            <end position="1173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1330"/>
            <end position="1359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1475"/>
            <end position="1527"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1186"/>
            <end position="1220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1475"/>
            <end position="1496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1497"/>
            <end position="1527"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG5104090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="1741" mass="192347" checksum="00B515DA47D62991" modified="2022-05-25" version="1">MFQICGEGVILLNNNSTASRICSMSDEGRVMSSEALKDDELFEIRIDKKIRSRYGKIEIGVCTNDPETMRTVGWTPSLQIWMMTNAGIIHTTNDLKEHLISEPTYGTATNVPTRLYTVVAMFFDFVQVTITNPKPLLLTNEPKDEMEINNDFSMGEGTSTSMVANLNVNLNVNMNVNLPKNPSPAAIREDRLRFHERVGSLVKLSNNARTAERRRPLDEFNNGVVMTHRPLRDNELFEIRIDRLVDKWSGSIEVGVTTHSPTGLKFPATMTNMRSGTTMMSGCGILTNGKGIQREYGDINLDELREGDRVGMIRRCNGNLHYLINGLDQGIAAKVPPGIWGVVELYGMTVKVTIVDRDEREEQNLVTRRNNLHLQGLTEVEEEETLDRLTFHPCCGTHADVINNGRTAHRPNAMDDFNNGVVLTMRPLRPNELFEVRLDKIVTKWAGSIEIGVTTHSPTELEFPFTMTNVRSGTWIMTGNGVMHNGTSIIDQYGQNLDRLQVGDRVGVMRKDTGTLHFFVNGTDQGAAAVGVPERVYGVIDLYGQATQATIVDNTDFYSPTTNNSSFSNTTLYSDLRFHHVHGKHARISNNGLTASRIRALGEFNEAIVIANRPLRDGELFEVSIDKMVGRWSGAIEAGVTAIRPDELEFPSTMTDIDHDTWMLSGSTVMRDGVTLRHHYSCDLDKLVEGNRIGMMRCADSSLHYYLDGVDQGTACSGLPPHVYPVIDLYAQCAQVTIVQPERRDTITQQYLPSENSISQQPTSVIQPQAPMEITHKFHESVGLNIQLNTDRVIAARCREYNNAVLLSESGLENNELFEIAIQEVAYEWSGSLKIGVVENPNGNWLTSMDLVPGMTSIPVDAWYLTGNEVRYKGNVLSSNYCPSLDWLRVGDKLGVKRSHEGNLKFYINGEDMGVAAVNVPEMVWVVVELFGSTVAVSITSSKQQLPAISPNASLRLQDSLELLLDPMPLTMRNDGGMDTSIDASEAKLQEIILTPTQPIITSTGETVDWCYEFHENHGRNVELEGQTVARRVASYNQGVVMTNRPLIKGKIFQVEIEKVNDRWVSGILCGVTCISPEKASFPLTALGFKKYSWIICSDWMSHNGTKVKTRYGGNLESVQAGSTVGLLIDEDSRLHLYVNGSDQGVAATDLPPYVYGVIDLYGQVEQVSIVGPVAEAVLTNNDAINMAIANNVERVSDEIEDVENSREKADLECHEKENVLEIPSSLPLNIQDELTNFNAIQTTSSRGNLLENATANIAAPSTASIDNITHFNNDLPGKSMTSSCNSDSNNSTSELEISNEPLVTATATTTAGSVVVVADGLECFKFKNNINHPDDSYDNNTMSNNDLDNDNDNQDEQVSNGMMMSSLRNNDCTNVEINNATNINIKNGSAATSSNMSSLNTAINSMNANNAINESIASNGQLNNIPGFHQNSNNLNVNVNLNNINQDNNSQCNLLSNLAATSFNTSITLQSQESQSINRQQLHQSKQNSNSAILPNQNQISSHNSQQSTLSSTRTSSSPPTPLNSTIILSPSKKCEYLKACKRLKKSLVLPDEFFSLDEITCYCNLCYKVDSDGAICKKGDPPAEFAVPIGWVRFPLKQTINANQIPQSTTDKWHVAYYGTRLDSIRWILDRGELLPMEQLDTSNLTTIIDSEDQNPQVVFSPNIKYVASEGIKKYPYIDTQSNKKLNASTAFQLLVRPGSYTMGSDKQHGADGVEPMEWATKEAGATVIIALLINLDEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MRR3</accession>
    <name>A0A8J2MRR3_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF243 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HICCMSTLAB_LOCUS5884</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5092055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MRR3"/>
    <dbReference type="OrthoDB" id="6376010at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062129">
        <property type="term" value="C:chitin-based extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008010">
        <property type="term" value="F:structural constituent of chitin-based larval cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040003">
        <property type="term" value="P:chitin-based cuticle development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004145">
        <property type="entry name" value="DUF243"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31927">
        <property type="entry name" value="FI07246P-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31927:SF16">
        <property type="entry name" value="LP07342P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03103">
        <property type="entry name" value="DUF243"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00690">
        <property type="entry name" value="DM5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035173757" description="DUF243 domain-containing protein" evidence="2">
        <location>
            <begin position="16"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="DUF243" evidence="3">
        <location>
            <begin position="117"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="241"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="241"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="270"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG5092055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="292" mass="27752" checksum="BEB475B76421081F" modified="2022-05-25" version="1">MRVFMIVALATAVVARPEAGYNYQSPGSTYGAPGGGSFSSGGLSSSSFGIGGGSSGGSSGGGFSSGGFSSGHGSGFGGGSGFGGGSGGSFGGFSGGSSGGFSGGSSGGFSGGSSGGALIQKHIYVHVPPPEAPEEPRFRPQLQTAAPQKHYKIIFIKAPTPPAPTAPVIPALQQDEQKTLIYVLVKKPEDAPEINLPTAAPTQPSKPEVYFIKYKTQKESGSSGSIGGGVSGGSIGGGIGGGHGGSIGGGHGGSIGGGHGGSIGGGDHGSTGSSGPSAPGPSYGTPGQSGPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MSD7</accession>
    <name>A0A8J2MSD7_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Proline-rich transmembrane protein 3/4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HICCMSTLAB_LOCUS11693</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5103805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MSD7"/>
    <dbReference type="OrthoDB" id="10066605at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059081">
        <property type="entry name" value="PRRT3-4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052836">
        <property type="entry name" value="PRRT_domain-containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35578:SF6">
        <property type="entry name" value="PROLINE-RICH TRANSMEMBRANE PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35578">
        <property type="entry name" value="PROLINE-RICH TRANSMEMBRANE PROTEIN 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25987">
        <property type="entry name" value="PRRT3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="53"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="85"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="126"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="160"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="189"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="653"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="686"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="domain" description="Proline-rich transmembrane protein 3/4" evidence="9">
        <location>
            <begin position="35"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="308"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="523"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="343"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="356"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="416"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="537"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="563"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF25987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAG5103805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="715" mass="80217" checksum="B88D2B6737067A81" modified="2022-05-25" version="1" fragment="single">MDRLPDWTYGVNGTTSQPGQNCGNATSLSRDEILVTAPSWTAVNQHLKWIFPLHSYGFACLFFVLSFYTLFSILNLRSLISSRPFMITINVFLCILGASRSGCLFIDPYNLQETMPKVIGSIMWDIGFPCVTSAFCLVQLAFLQLTQIKFGPKRLQKESWLSFVITSHFSFVIASDVALAFHNHYVTKYVVQTLFLIWSIILYLTFLHAGYKAMDIVRTLPSNALIRDSSLGNQKGIMQLAMLAPYNNLASSVAAALVPTLFSQRTKSEDTEIININCNENIKMENERRDQFNSNSTAISNVKNNKDYTNQQQQQQQTSTVPEVYVRPPTPTPSAVLPIITVSCPSRRSSLANSRRGSDVSGRESRRSSASSVKFINEEDNSSIAEKKSPVTDRPVTPEGILRRNSDIQTPTGSIKDLRRCSDFSHEKNRTSQFATKLRRNSDFGNRTPKRMLPTDEPRLPQVLDVSPSSSRRNSDLGGLAAVKIPESRRNSDISYRRSSDIGQIRPLFMNRRTSDVSIKTLDKSPTHFQSTVPKMEILENKSESDSDQHDYCNEKAALMNNDKPKSKEEDNRGRKKSLSWKNIDKFKDDQDITAESSLLPDNNNSASDRGGSDFTLHAILNHIANVNRAKTDIPLQIESSCGVSRKSQVRRVLHVIYATAVLGIILCATLNYGERLEAVKYPKPLPWIIYQTICRGLELIMGCCMASITKQSSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MTI4</accession>
    <name>A0A8J2MTI4_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Similar to Cubn: Cubilin (Rattus norvegicus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HICCMSTLAB_LOCUS12675</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5107290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MTI4"/>
    <dbReference type="OrthoDB" id="6022136at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00041">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.400.10">
        <property type="entry name" value="Low-density Lipoprotein Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.290">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000859">
        <property type="entry name" value="CUB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036055">
        <property type="entry name" value="LDL_receptor-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002172">
        <property type="entry name" value="LDrepeatLR_classA_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053207">
        <property type="entry name" value="Non-NMDA_GluR_Accessory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035914">
        <property type="entry name" value="Sperma_CUB_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47537:SF6">
        <property type="entry name" value="CUB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47537">
        <property type="entry name" value="CUBILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00431">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00057">
        <property type="entry name" value="Ldl_recept_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00042">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00192">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57424">
        <property type="entry name" value="LDL receptor-like module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49854">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01180">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50068">
        <property type="entry name" value="LDLRA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035202787" evidence="5">
        <location>
            <begin position="32"/>
            <end position="905"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="805"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="6">
        <location>
            <begin position="64"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="6">
        <location>
            <begin position="206"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="6">
        <location>
            <begin position="348"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="6">
        <location>
            <begin position="492"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="6">
        <location>
            <begin position="630"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="861"/>
            <end position="905"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAG5107290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="905" mass="101248" checksum="D9A1CF3618C0CE5A" modified="2022-05-25" version="1">MASVLWHASGSSFVSPAIIFLLLLCPHAITAREVIDVPQPQQDYVPSLSPPPPGPFATAKTSRCDQTFVSVPGSPENGTFHAPYLINPKRESQQCVYTFLAGPYQRAEVVFTTFGLRGTPPECVHEYMDVYTQIRSDNTTKLIETPFGGRYCGPIPPRRRVSLYRGIALSFYTDKNITLPTLFSGRYAFINASEYEIGTPVPGTPCSFVVNTTIKRTGSILSPTYPGAYPKNLTCRYQFIGNSGQRIRLEFRDFDLFYGGPHCPFDYVKVYDGLDLKSAPVIGTYCGQQRNLVLYSSQSNLTVLFSTLQRTANTQNRGFKGIFEFSEGFVKLDFINKSGGMHIRGSECDQKILSTRESNGSVVSPNYPFPYIPKVVCRYFVYGMQDAQHLERVKLEFLTFDISKGEAKGDSACTDGYLKIYLKGQEATDSYDKFDYELCGNETNPSQVVSDGPRLVMVFSSGELKQGRGFKARYSFETEYKIPGTAAPDGSCTFTYRSSSRKKGEFNSPRYPSNYPSDINCTYLFLATPNEQVTLVFDHFKVRSQPSNSTTGFYGEEICQNDWLEIYNMYRDNTEKLIGRYCGTSAPGPVESNLGALGVKVILHSDAELVYSGFKARYMFEVAKSIFGDCGSNISSLEYGVIMTPNHPENYDSPLRNFASKTCNWFISVRPDHQILIYFEDFSVEGEQSVRGCPAAVLRLWLSPMATPIELCGVKTSDGPNDYLSQDHNMRLSFISSDKSVGQKGFRAVWTEVYKANECEPNEFHCSGNNYCIAETLRCNNVDNCGPNDTSDEENCAISVPPVSYAIPAGSAAAAVLVALALCLLCHRKMKRRTEEVNIDDFQQRIEDMRYCYHHHTVFHRTPSTHSHSHPDTYNNQYHMEQPSPPSESEIEHVCGDDASSPETP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MWP8</accession>
    <name>A0A8J2MWP8_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Similar to ift172: Intraflagellar transport protein 172 homolog (Danio rerio)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HICCMSTLAB_LOCUS9987</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the IFT172 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5100914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2186662at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005930">
        <property type="term" value="C:axoneme"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030992">
        <property type="term" value="C:intraciliary transport particle B"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042073">
        <property type="term" value="P:intraciliary transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.470">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056168">
        <property type="entry name" value="TPR_IF140/IFT172/WDR19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056157">
        <property type="entry name" value="TPR_IFT80_172_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15722">
        <property type="entry name" value="IFT140/172-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15722:SF2">
        <property type="entry name" value="INTRAFLAGELLAR TRANSPORT PROTEIN 172 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24762">
        <property type="entry name" value="TPR_IF140-IFT172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23387">
        <property type="entry name" value="TPR_IFT80_172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101898">
        <property type="entry name" value="NHL repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0966">Cell projection</keyword>
    <keyword evidence="6" id="KW-0969">Cilium</keyword>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="IFT80/172/WDR35 TPR" evidence="9">
        <location>
            <begin position="628"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="domain" description="IF140/IFT172/WDR19 TPR" evidence="10">
        <location>
            <begin position="868"/>
            <end position="1019"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF23387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF24762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAG5100914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="1739" mass="193541" checksum="6061C0C7085B7BB5" modified="2022-05-25" version="1">MILKYIGCVLAANDGENRVVSIAWSPNNLKLAVALADRSIYLFDEAGVKKDRFSTKPVDAKYGKKSYVIKAISFSPDSTKIAVGQTDNIVYVYKIGEDWGEKKVICNKFGQSSSVTCMIWPSEGPIIVGLNDGKVRVAILKAHKAQTLYTADAMTLALAANERKTAFISSHADGSIIKYHLKNDGHTEPSGRILTHGVPAYALAWPHDHICAGGSDKKLTFYDSHGKVIKTLDYSRDNTDKEITVACSSPSGQSIAIGSWNRIRIIDWSPRRAVWEETISRVLPNFYTVTALAWRRDGSRLVIGGLCGAVEQFETVLKRAMVRGSHEVAYVGPSQVVVRSLSGSNRPVSIKSYTGSEIEDVRVLGRKDNHIIARTSSTLLISDIQLNLLSEIQWEDKSNSEKFFFEYPGVCLIFSSGELTIVEYGKNEILGSVRTEAVNPHVVSVRINERQVPGMPDNKRLAYLLDSRTVRIVDLISGSTISIIGHDARVDWLELSETGHRLLSRDKKARLWLCDDKASRILLLTGTGFASWVPGSDVAVAQTGDKLAVWYNVDAPEASTLISIRGDAVDIERDDGKTSVIVEEAGSRLNYPLDEGLIEFGTALHDNDFGRVILFLEDLGDRPEAEAMWENVARNAMTEKKLLIAARCYSALGDVAYSSFLKDIVRIGEEYAQETGNDPLTSPECWAKLAILNGELKTAEAIYLEQNELDKALEMYQKYWHWEEALDLAENRDWIGLKNLKDKHLAWLLNSGQAARAAAIIESEDPRRAVKLFLDAGRAGRAGRLLLSDESLLEDSKITGEVVKALKSSDLMELAGEILEKTNDTSGAIKCYQDAGIFARALDLARSVEPNSVVSIEKDWGYNLATAGHHDAAINHFIEAGEIAMALNSAINARQWRKALQIVQVIDSEDPAIQEKCYKLGEYCASNGDTNLAENLFLRAKHPKRAIEIHIKTNNWSRAYEVAMEHMESTEAVKVLIEHAEKLQEAGNFRYAEALFVAIGEYDAAIAMYRRAGHRHDMIRLVAEYRPDLLKTTHAYLARELTAAGKAREAEEHFIGAEDWRGAVAAYKANNLWEDALRVAKQESGDTAAQQVALMWARTLAPELGARLLIRLNYFDPCLLMACEANLFDWALDAVRYGTPEQQQEVHYKYAMTLEDEGKFAEAEKEFIRAGKATEAVQMYIHTRDWDAAEEVAQSVSQEAMAQVLVARAAEAVDNKDYAFAESLLLRAHKPEIIIDHYKLAGMWSEAMRVCREYLPSHEAALRRELTHRSSGIDGTNSLDEARRWLETGEVRTALDILILDSSRPALIQAAEILLNQADPEMVLQVGGELGSKLVVTGEHALAAQVFLQADKIKEAINALVSVGDWMRARRIVHELAPDLESYLDDKYRESARDSVLSDNDQGRSERDGDKSLENLARKGQWIQVFEIASSLNSEVLHKYLAQRAAQLLKSGTPEPALQLYSQYGAPPIAQYHNLYYRLAEMILNLYQGSPESRYTRLSQLRTFLLGLTKQIEGSSASEDKFGRLLQATHYSAVKCACQLFPNLANLVTKTSVSLLRYSDVLLVDRCYYEAGTQLRKSGSHSEAFVFLNHFLDLEECIEEGDGSTLDVDDLRITDFPLEVPRPGTLSLTQEEREDVREWVLAVSMDQKVEQGLPVDQRGVYIGSLTCPTNGSAALQPCALTGYPIRSSVVRFEGSNRVVDRDDWNKLINASRQAPSESPLNDVVAFIQEWCGSLPSFTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MX15</accession>
    <name>A0A8J2MX15_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="19">Similar to fz2: Frizzled-2 (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">HICCMSTLAB_LOCUS11099</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G-protein coupled receptor Fz/Smo family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5102606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MX15"/>
    <dbReference type="OrthoDB" id="10053709at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042813">
        <property type="term" value="F:Wnt receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017147">
        <property type="term" value="F:Wnt-protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060070">
        <property type="term" value="P:canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035567">
        <property type="term" value="P:non-canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15035">
        <property type="entry name" value="7tmF_FZD5_FZD8-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07456">
        <property type="entry name" value="CRD_FZ5_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000262">
        <property type="entry name" value="Frizzled 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.2000.10:FF:000004">
        <property type="entry name" value="Frizzled class receptor 8a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.2000.10">
        <property type="entry name" value="Frizzled cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015526">
        <property type="entry name" value="Frizzled/SFRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000539">
        <property type="entry name" value="Frizzled/Smoothened_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020067">
        <property type="entry name" value="Frizzled_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036790">
        <property type="entry name" value="Frizzled_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017981">
        <property type="entry name" value="GPCR_2-like_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11309">
        <property type="entry name" value="FRIZZLED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11309:SF126">
        <property type="entry name" value="FRIZZLED-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01534">
        <property type="entry name" value="Frizzled"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01392">
        <property type="entry name" value="Fz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00489">
        <property type="entry name" value="FRIZZLED"/>
    </dbReference>
    <dbReference type="SMART" id="SM00063">
        <property type="entry name" value="FRI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01330">
        <property type="entry name" value="Frizzled"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63501">
        <property type="entry name" value="Frizzled cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50038">
        <property type="entry name" value="FZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50261">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="11 14" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="10 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0675">Receptor</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="13" id="KW-0807">Transducer</keyword>
    <keyword evidence="6 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0879">Wnt signaling pathway</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="253"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="289"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="336"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="378"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="417"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="460"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="507"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="domain" description="FZ" evidence="17">
        <location>
            <begin position="1"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 2" evidence="18">
        <location>
            <begin position="253"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="103"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="15">
        <location>
            <begin position="130"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="2"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="39"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="66"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="70"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="CAG5102606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="617" mass="65936" checksum="3EA6435568C6453A" modified="2022-05-25" version="1">MCRGIGYNLTAMPNELNHDTQDEAGLEVHQFWPLVEIKCSPDLKFFLCSMYTPICLPEYSKPLPACRSVCERARAGCAPLMQQYGFSWPERMACERLPNQGDPENLCMEQDNHTSSGGSGGSGGPASMAPLPPGPPRPPRPTKPSTTSRCKGKNSKNCQHPPGERARDCLCRCKAPLVPLGVTSSGIGTSGHAAGILGVGAGATHIVGVPVSPIGLDTITLTNNPNYPGIAGVRDCALPCHGVLLSPEERGFAAVWLTLWSGLCAASTLTTVITFLIDTQRFKYPERPIVFLSACYFVVSLGYLARSVLGHEEIACDGPALRSGAQGPGTCVTVFLMIYFFGMASSVWWVILAFTWFLAAGLKWGNEAITSYSQYFHLAAWLAPTAQTVWALLAGGIAGDPVAGVCTVAPEGVQKFILVPLLVYLLLGTSFLLAGFVSLFRIRSVIKRQPGAKADKLEKLMIRIGVFSVLYTVPASAVLGCYLYESTQRDEWIAHLACPCRPQSKPIYSILMLKYFMALAVGITSGVWIWSGKTLDSWRRLWRRLFGGGVAAGGNTGLAGVTGVSGIGSASMKGRSMMPSYAASGPGSALLPPGSVASASQHHLHHHVLKQPPLSHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MXL8</accession>
    <name>A0A8J2MXL8_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="5">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">HICCMSTLAB_LOCUS11690</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the peptidase C64 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="5"/>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5103799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MXL8"/>
    <dbReference type="OrthoDB" id="10064699at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070530">
        <property type="term" value="F:K63-linked polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071947">
        <property type="term" value="P:protein deubiquitination involved in ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035871">
        <property type="term" value="P:protein K11-linked deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071108">
        <property type="term" value="P:protein K48-linked deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070536">
        <property type="term" value="P:protein K63-linked deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22768">
        <property type="entry name" value="OTU_OTUD7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051346">
        <property type="entry name" value="OTU_Deubiquitinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003323">
        <property type="entry name" value="OTU_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002653">
        <property type="entry name" value="Znf_A20"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13367:SF27">
        <property type="entry name" value="OTU DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13367">
        <property type="entry name" value="UBIQUITIN THIOESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02338">
        <property type="entry name" value="OTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01754">
        <property type="entry name" value="zf-A20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00259">
        <property type="entry name" value="ZnF_A20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50802">
        <property type="entry name" value="OTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51036">
        <property type="entry name" value="ZF_A20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-0645">Protease</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="11" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="14" id="KW-0862">Zinc</keyword>
    <keyword evidence="10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="OTU" evidence="17">
        <location>
            <begin position="76"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="A20-type" evidence="18">
        <location>
            <begin position="487"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="17"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="CAG5103799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="520" mass="57289" checksum="1C92FF4D127FFC88" modified="2022-05-25" version="1">MSSTLSMYDGLEPDVPTNNSTTLSTGGTDGVGGAGDSFRQFLERDLIEGGCLTSLEAAGRLNWWCGGKNSSSVRVLWPLATTGDGNCLLHAASLGMWGFHDRLLTLRDALHNTLSKGEYKDALFRRWKWRQMGLNAAAGLAYTETEWLTEWQSIVEMASANPRSQTATSYQSLEEVHVLALAHVLRRPIIVIAETMLRDCEGVALAPIPFGGVYLPLQVSPAKCHRTPLLLAYHSAHFSPLVTVDCGNEFAASANGIGDTTGVSIPLVDPDTGQLLPVLFAVDPGPDWDWTASQDLLLCHQDTMEILIRDYLDCEYQTLTTEDLDRLSDTDGSLTGKSKAAKQLLGVAKQFGSIGKSMSKKLWSSMAKRPKSPPTSALAGLTTEGVLCVKLKSHRHQYVDQMLQNYLQCAHSRYLEMQKDASGTEINYGAGKSKFYTVSDSNSHASVSKLQPKNTNKDRTLYLSRSTFYNNITAPEPREYNEFKRNSGSVRECLTEDCPFFGSPENDYYCSKCWANNSQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MY38</accession>
    <name>A0A8J2MY38_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HICCMSTLAB_LOCUS11333</name>
        <name evidence="7" type="ORF">HICCMSTLAB_LOCUS13641</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5103085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5109005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MY38"/>
    <dbReference type="OrthoDB" id="7704626at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036433491" description="RING-type domain-containing protein" evidence="4">
        <location>
            <begin position="21"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="5">
        <location>
            <begin position="56"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="5">
        <location>
            <begin position="158"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="116"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="196"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="121"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAG5103085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAG5109005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="215" mass="24177" checksum="5E0B80E7C588002A" modified="2022-05-25" version="1">MNPFAGAALTTLCLVVGAVAATIFAFSQRQYNNNHHENHHNRQNKFNPRRARNLTCPFCGQAVVANDYPLACGHLCHVTCFRARLASRRDNCSFCYDDQDDEAVLKESFSRMDEEVRYRTNHQSSSNINENDVTPASAPESTSGTASTTTKEVCCAFCKVWLEIPADQKQLTCGHYAHNNCFEKLKHLVKCQECTNDSSDSEDEIESPSHFVPKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MYE3</accession>
    <name>A0A8J2MYE3_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">phospholipase A1</fullName>
            <ecNumber evidence="4">3.1.1.32</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HICCMSTLAB_LOCUS11544</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 2-acyl-sn-glycero-3-phosphocholine + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18689"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="ChEBI" id="CHEBI:57643"/>
            <dbReference type="ChEBI" id="CHEBI:57875"/>
            <dbReference type="EC" id="3.1.1.32"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the AB hydrolase superfamily. Lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.32" evidence="4"/>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5103507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MYE3"/>
    <dbReference type="OrthoDB" id="199913at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008970">
        <property type="term" value="F:phospholipase A1 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00707">
        <property type="entry name" value="Pancreat_lipase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000033">
        <property type="entry name" value="Pancreatic triacylglycerol lipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013818">
        <property type="entry name" value="Lipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033906">
        <property type="entry name" value="Lipase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002331">
        <property type="entry name" value="Lipase_panc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000734">
        <property type="entry name" value="TAG_lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11610:SF185">
        <property type="entry name" value="LD47264P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11610">
        <property type="entry name" value="LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00151">
        <property type="entry name" value="Lipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00823">
        <property type="entry name" value="PANCLIPASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00821">
        <property type="entry name" value="TAGLIPASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="Lipase" evidence="9">
        <location>
            <begin position="71"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAG5103507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="550" mass="61906" checksum="01FB5D696EEF9F75" modified="2022-05-25" version="1">MFLNETLVLLTYTANMMATLPNETSSKNFSNINVDGHSDSEANNNYLITTLSPEEEENKFNLEDDWYMWRCYQPYGCFYIGAPWSGENRPVSTFPGRPESVDPHYMLYTRERSNDPYELLIDQLDIIRKSPLKNNVTLYFIVHGYLDNGDKTWILRTKRELLIREDCNVVVVNWIAGAGPPYPQAVANTRLVGAMTARLAMQLIQEAGVPEHRFHAIGHSLGAHTCGYIGYYLRVQYGYKLGRITGLDPAEPHFSNTSPMVRLDPTDAEFVTAIHTDSSPFVTGGLGITQPVGHIDFYPNGGRNQPGCNHGVLNSITLERGSFFRGIKRFLGCNHIRSYDYFIESINTNCPFIAVPCSSWSNFQEGKCFDCIRGHYKITINISKTAESVDHGGEVGMFVIRVIGAATNDSNHNYEHDSDRDSDIKISERLEISEASKYYEPGSSHTVVLPGEIVGTPEAVEITWEYQTSVFNPLTWRLLHKPKAYIDSLRIDSLEAGQGYCVLKLGSRFIEYQSITVCPDEGKTITANEPKILTAENCRYHTPDSNVISH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>S6CVV3</accession>
    <name>S6CVV3_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cc_vank.3_14.2</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">Viral ankyrin VANK-3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">vank-3</name>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS1424</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Philos. Trans. R. Soc. Lond., B, Biol. Sci." volume="368" first="20130047" last="20130047">
            <title>Functional endogenous viral elements in the genome of the parasitoid wasp Cotesia congregata: insights into the evolutionary dynamics of bracoviruses.</title>
            <authorList>
                <person name="Bezier A."/>
                <person name="Louis F."/>
                <person name="Jancek S."/>
                <person name="Periquet G."/>
                <person name="Theze J."/>
                <person name="Gyapay G."/>
                <person name="Musset K."/>
                <person name="Lesobre J."/>
                <person name="Lenoble P."/>
                <person name="Dupuy C."/>
                <person name="Gundersen-Rindal D."/>
                <person name="Herniou E.A.Drezen.J.M."/>
            </authorList>
            <dbReference type="PubMed" id="23938757"/>
            <dbReference type="DOI" id="10.1098/rstb.2013.0047"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CAJNRD030001116">
        <property type="protein sequence ID" value="CAG5075270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="HF586477">
        <property type="protein sequence ID" value="CCQ71341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S6CVV3"/>
    <dbReference type="OrthoDB" id="20727at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051059">
        <property type="term" value="F:NF-kappaB binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071356">
        <property type="term" value="P:cellular response to tumor necrosis factor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051070">
        <property type="entry name" value="NF-kappa-B_inhibitor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46680">
        <property type="entry name" value="NF-KAPPA-B INHIBITOR ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46680:SF3">
        <property type="entry name" value="NF-KAPPA-B INHIBITOR CACTUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5075270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCQ71341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="166" mass="18729" checksum="369CD470B6BAEDD8" modified="2016-04-13" version="1">MAQNNIIQNRVQDAAAFEEEKNRFFSICRSGNIFEFMESVPFLSNVGHLVHEYDHHGRLCTHMVARFDLNNAVMKIELLLNMGADVSARESLTGDSLLHIAVSSKNYELAEWLCRDLKANLIAINYAHLTPYHLAYFFRDQRMMEILKSNGAVCDDPVTSGGSGGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-10-16" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>S6D4U7</accession>
    <name>S6D4U7_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cc_vank.7_16.1_pseudo</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">Viral ankyrin VANK-7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">vank-7</name>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS6230</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Philos. Trans. R. Soc. Lond., B, Biol. Sci." volume="368" first="20130047" last="20130047">
            <title>Functional endogenous viral elements in the genome of the parasitoid wasp Cotesia congregata: insights into the evolutionary dynamics of bracoviruses.</title>
            <authorList>
                <person name="Bezier A."/>
                <person name="Louis F."/>
                <person name="Jancek S."/>
                <person name="Periquet G."/>
                <person name="Theze J."/>
                <person name="Gyapay G."/>
                <person name="Musset K."/>
                <person name="Lesobre J."/>
                <person name="Lenoble P."/>
                <person name="Dupuy C."/>
                <person name="Gundersen-Rindal D."/>
                <person name="Herniou E.A.Drezen.J.M."/>
            </authorList>
            <dbReference type="PubMed" id="23938757"/>
            <dbReference type="DOI" id="10.1098/rstb.2013.0047"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5092566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="HF586473">
        <property type="protein sequence ID" value="CCQ71282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S6D4U7"/>
    <dbReference type="OrthoDB" id="20727at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051059">
        <property type="term" value="F:NF-kappaB binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071356">
        <property type="term" value="P:cellular response to tumor necrosis factor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051070">
        <property type="entry name" value="NF-kappa-B_inhibitor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46680">
        <property type="entry name" value="NF-KAPPA-B INHIBITOR ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46680:SF3">
        <property type="entry name" value="NF-KAPPA-B INHIBITOR CACTUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5092566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCQ71282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="103" mass="11956" checksum="1C508D5D0684A3F9" modified="2013-10-16" version="1">MKLLTLWGANVNGKELKGGDTPLHLAVRAQNYTLVEWLCQQPNVNKEAMNNDLMTPYHIAFFARDDKMMDVLKQNGVQCRVPLQSETNSYDEDYEPECKFQRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2E596</accession>
    <name>A0A8J2E596_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">ATP-dependent RNA helicase DDX42</fullName>
            <ecNumber evidence="3">3.6.4.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">DEAD box protein 42</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">HICCMSTLAB_LOCUS641</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the DEAD box helicase family. DDX42 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="3"/>
    <dbReference type="EMBL" id="CAJNRD030001114">
        <property type="protein sequence ID" value="CAG5073861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2E596"/>
    <dbReference type="OrthoDB" id="196131at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd17952">
        <property type="entry name" value="DEADc_DDX42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000524">
        <property type="entry name" value="ATP-dependent RNA helicase DDX42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000079">
        <property type="entry name" value="probable ATP-dependent RNA helicase DDX17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 16 21" id="KW-0347">Helicase</keyword>
    <keyword evidence="6 16" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="20">
        <location>
            <begin position="260"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="18">
        <location>
            <begin position="291"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="19">
        <location>
            <begin position="496"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="67"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="133"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="652"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="15">
        <location>
            <begin position="260"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="17">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="35"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="142"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="17">
        <location>
            <begin position="181"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="17">
        <location>
            <begin position="695"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="711"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="17">
        <location>
            <begin position="723"/>
            <end position="732"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00061633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00068282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00075438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="CAG5073861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="732" mass="81350" checksum="8B3E116A017BCC1E" modified="2022-05-25" version="1">MSYQRGGGNKPRGFGFTSFQMGSKRSGVNIPPPASINTSSSLSKQGYHTMNSITENALSACWGMPKKRTKTEDEYFEDDDETPASTLEYIPAPGSPTYELMNQKSKKNDSDSEEDPLDAFMAGIDAEVQRNNKAALASTAEDSEKQDKSHKGVRQDIDEEDNEESYYRYMEENPTAGLQQEESDTEIEYDEDGNPLAPPRKKEIDPLPPIDHSEIEYEPFEKNFYNVHEDIACLTKSQVDELRKTLGIRVSGAAAPKPVASFGHFGFDDALIKAIRKNEYTQPTPIQAQAIPTALSGRDLIGIAKTGSGKTAAFIWPMLVHIMDQRELKEGDGPIGLILAPTRELSQQIFHEAKKFGKIYNIQVCCCYGGGSKWEQSQALANGAEIVVATPGRMIDLVKMKATSLSRVTFLVLDEADRMFDMGFEPQVRSICNHVRPDRQTLMFSATFKKRIEKLARDVLTDPVKIVHGDVGEANTDVTQHVIVFNNNPTGKWTWLLQNIVEFLSAGSLLIFVTKKLNAEELSNNLKLKEHEVMLLHGDMDQVERNKVITAFKKKEVSILVATDVAARGLDIPHIRTVVNYDIARDIDTHTHRIGRTGRAGEKGTAYTLVSEKDKEFAGHLVRNLEGADQEVPKSLMDLAMQSSWFRKSRFKGGKGKSLNVGGAGLGFRGRPTSSNQFRASSDHTWEQTIQPPSVVMPPPPPPPGPGSGSEESKNQTSEKSDRKRVRKSRWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2E8E8</accession>
    <name>A0A8J2E8E8_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Ionotropic receptor 75u</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HICCMSTLAB_LOCUS248</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001114">
        <property type="protein sequence ID" value="CAG5073258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2E8E8"/>
    <dbReference type="OrthoDB" id="6117597at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015276">
        <property type="term" value="F:ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050906">
        <property type="term" value="P:detection of stimulus involved in sensory perception"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052192">
        <property type="entry name" value="Insect_Ionotropic_Sensory_Rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001320">
        <property type="entry name" value="Iontro_rcpt_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057074">
        <property type="entry name" value="IR75A_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42643:SF33">
        <property type="entry name" value="GLUTAMATE RECEPTOR 2-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42643">
        <property type="entry name" value="IONOTROPIC RECEPTOR 20A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24576">
        <property type="entry name" value="IR75A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00060">
        <property type="entry name" value="Lig_chan"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 13" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="223"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="296"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="483"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="domain" description="Ionotropic receptor 75a N-terminal" evidence="12">
        <location>
            <begin position="6"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="Ionotropic glutamate receptor C-terminal" evidence="11">
        <location>
            <begin position="223"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="512"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="526"/>
            <end position="535"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF24576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAG5073258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="541" mass="62267" checksum="B5E82CF3B3999201" modified="2022-05-25" version="1">MFVAPTRWLLLQDTTTNNSSQINLKNQFDGLGIFPDSELYLAQRLKNDSINILSIYRPSMYVNLIFEYRGNWDALNGVNFVDSIPASQRRRNLHLTPLKTCLVLVNPDTLNHLTDYKDKRIDAVTKANYIWMMHLVNRINATVTYTWRNTWGYQDQNGTWSGMIGLLDRNEIDFGGTATFLIKQRIGVIEYLHLYTPVGSKFVFRKPPLSYVSNLFTLPFGRAVWYAIAVMTCVICGFLYITLKWEWKKTLESEEDTRHPDDLQKDPSLSDDLLILSSAIFQQGLSYEPRTISSRIITLMLLLAALSLYASYTANIVALLQSTSNSINTLKDLIQSGLKFGIYDIVYNRYYFGALDDPIRREFRERFVTNKSSIWLTMEDGIERVRKGLFAFHVDTAAGYQLMQETYDEDEKCGLQEIDYMGVLDPMLIIKRRSPYREIFKVGSLWLREAGLQQRDTPRLFTKKPVCVGQTSFISVGTTECYAAFYTIIYGVAIAFGVLFIEIIYHRCRESKNDDSSESENDVEQHQQSRQTSGESLEAIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2EBW4</accession>
    <name>A0A8J2EBW4_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS1269</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001116">
        <property type="protein sequence ID" value="CAG5075106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2EBW4"/>
    <dbReference type="OrthoDB" id="6107953at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="147"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="320"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="421"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="727"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="770"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="807"/>
            <end position="934"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="959"/>
            <end position="1016"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1055"/>
            <end position="1083"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="421"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="807"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="824"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="855"/>
            <end position="876"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="889"/>
            <end position="904"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="972"/>
            <end position="987"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1055"/>
            <end position="1066"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5075106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="1132" mass="123987" checksum="5BCF09154C907B7D" modified="2022-05-25" version="1" fragment="single">PNDSSPPGKISISLKQKFITTSLNFSTLHPLTYKTSSKQTFIYTYLNNIYTNINLNNIISTELATTGFGPAPPPPPPPPTGQMPTMRINTEMPRRPQMYTNDPYEPPAAIQNAMMTKDKKPFTYTPGMGGKLDLSQIRSPRMARRVAKNANDEGIEGPPKSPLANEAYNSRSVPGAVPGMTLVPGTVPGTVPLHGMGSVPGTVPLPGMGSVPGTGSVLGTATVPVTPPGPASLFIQPQVAVPVFPTNVPKTIEDRPSVFTIKNEPGHHQFKTPPQQRWGNQNTTAKVTVAPPKPQLTAPGTYIVPIAVEGAQELPSYEFQPTSANQSRNQGRNIQDLSGAPVQSRSFRVLQKLTDTDNDDIDNEQLRKLQLTEDDKVLMNKFKEQVDGDTYLHQEEDPRYRGAAIPSRAFRYLQNMTDSNEVPINNDEQPVVQNLPPSEQQAPEPKKYTGSAIPSRSFKILQAMTTPDALASREIPVGHQGLFVPYTTPVYWAYYPLAYVPNQEQVPCANPNNLNNIGCYPGVFFVGVDKLDDFVTSNEIASQDLTLESEKSHLEREKCQSLAAKELGLMVPGGSGHGKAEELVGNPPQSGTMMSNGTQAQEVVLNQPGTMFTEGSNQKEALEPLKNQLGLQGTALDGVLYCSRDAQGQELVLKQPGTIYREGSNQKKALEPSINHLKLQETTLADVACYLKASNLVTNHLQSQNMTLNSAQSHELVPNQPGTMIKAGSSSYKTSDKTTSHPQSPELLTNDVPTYNLIITQSKMKLRINPTRNEASNPSNIQKTAFPETSNHLKASDLTYNSAQYQKNDVPNQPQASFDPGSTKVPTSSQNQNLPTSNLTAIQLGTPPELPCSTVPASKNQEQATIDGPSSYQANCPMNILHEEEDTSDSSNNVDDGVPETSTDSDSDSYLAYSTGLNPDSDSKDSVEEGPTVNVSLPLKTKSCSEEVHVDFTLSRPKSWCPEPSKFQEQKEETEEHQDKETDDDDSGVNSQSDLSRMISEVDTDSECSPRKVSSYKRTQTHSRLFKLISKNDSPFFEDTKEEMISLKKSSRITIKNSNSPAQSLNFPAKAPPGGTPRNFRRPLSLEVREDDFYLKWKNSNGKKGNLERKFVKPTVLCPRTKSFKNLTKLSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2EGH1</accession>
    <name>A0A8J2EGH1_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Similar to Ras64B: Ras-like protein 2 (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HICCMSTLAB_LOCUS1144</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Endomembrane system</location>
            <topology evidence="10">Lipid-anchor</topology>
            <orientation evidence="10">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small GTPase superfamily. Ras family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001116">
        <property type="protein sequence ID" value="CAG5074933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2EGH1"/>
    <dbReference type="OrthoDB" id="5976022at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04145">
        <property type="entry name" value="M_R_Ras_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000080">
        <property type="entry name" value="Ras-like GTPase Ras1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020849">
        <property type="entry name" value="Small_GTPase_Ras-type"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24070">
        <property type="entry name" value="RAS, DI-RAS, AND RHEB FAMILY MEMBERS OF SMALL GTPASE SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0488">Methylation</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0636">Prenylation</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00046278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAG5074933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="198" mass="22850" checksum="3400FD56390FCFA9" modified="2022-05-25" version="1">MSRNGERSYAQTYKLVVVGGGGVGKSAITIQFIQSYFVTDYDPTIEDSYTKQCVIDDVPAKLDILDTAGQEEFSAMREQYMRSGEGFLLVFSVTDHSSFEEIAKFHKQILRVKDRDEFPMLMVGNKSDLDHQRYVPMDEAQNMARVLKIPYIECSAKLRMNVDQAFHELVRIVRKFQLSERPPLKPNYKKNKKKCCML</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2EIM2</accession>
    <name>A0A8J2EIM2_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS582</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001114">
        <property type="protein sequence ID" value="CAG5073743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2EIM2"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5073743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="99" mass="11986" checksum="B7103CC4BBB2E865" modified="2022-05-25" version="1">MDRERWPWIIMKEEMRGILNGRATKWGKEVKKILEKMGCEEVVRMIYKEQEIEEIETKLDEGIMRIKEETKKEDEEAIEKSSYCKLYKKIKITIGEKMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2EL60</accession>
    <name>A0A8J2EL60_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Similar to Myosin regulatory light chain 2 (Bombyx mori)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HICCMSTLAB_LOCUS2201</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001117">
        <property type="protein sequence ID" value="CAG5076489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2EL60"/>
    <dbReference type="OrthoDB" id="429467at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009791">
        <property type="term" value="P:post-embryonic development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000007">
        <property type="entry name" value="Putative myosin regulatory light chain sqh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050403">
        <property type="entry name" value="Myosin_RLC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23049">
        <property type="entry name" value="MYOSIN REGULATORY LIGHT CHAIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13405">
        <property type="entry name" value="EF-hand_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="5">
        <location>
            <begin position="76"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="41"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAG5076489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="155" mass="16794" checksum="7170C913EA834724" modified="2022-05-25" version="1">MADKEKKKKTKKKEDASPTPAPAAAASPTPPPESPKEAPKSKSPSGTPSGSQRASSRGSKRAKRAGSSVFSLFTQKQVAEFKEAFQMMDHDKDGIIGKEDLRQTFDSVGRLATDKELDAMLEEVEGPINFTQLLTLFANRMSGGSYETILPFKTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2ELS3</accession>
    <name>A0A8J2ELS3_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS121</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030000716">
        <property type="protein sequence ID" value="CAG5071972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2ELS3"/>
    <dbReference type="OrthoDB" id="7701102at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5071972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="266" mass="30375" checksum="D7677C28202AABB3" modified="2022-05-25" version="1">MLSNSEHPITLLLDKLVANRDNSLLVTRGPRPLLLVACEDLIPIQHYIASTDKPWCYAYSYESLWFVPDVDLDCGISIQESKNPNSKFESLFRQELIRGNCWFTDGSKIPEQEFVGFASVNVSAGAIETCRTVKYASIFTAEAMAIYTTLEKFFQNNEHHFNIFKGASPWFKNFTFCRKTIVSINRLRSGHTSLAASLFRFKIVNSDQCSSGEAVEEPNHVFWQCKLYDKAREYLITDLIKAKIFPPYDIESQLSEMNPLFVIPIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2GZN0</accession>
    <name>A0A8J2GZN0_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Similar to DCP1B: mRNA-decapping enzyme 1B (Bos taurus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HICCMSTLAB_LOCUS827</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DCP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001114">
        <property type="protein sequence ID" value="CAG5074055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2GZN0"/>
    <dbReference type="OrthoDB" id="440673at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008047">
        <property type="term" value="F:enzyme activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000290">
        <property type="term" value="P:deadenylation-dependent decapping of nuclear-transcribed mRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031087">
        <property type="term" value="P:deadenylation-independent decapping of nuclear-transcribed mRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000184">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09804">
        <property type="entry name" value="Dcp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2030">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010334">
        <property type="entry name" value="Dcp1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031953">
        <property type="entry name" value="mRNA_decap_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16290:SF0">
        <property type="entry name" value="DECAPPING PROTEIN 1, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16290">
        <property type="entry name" value="TRANSCRIPTION FACTOR SMIF DECAPPING ENZYME DCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06058">
        <property type="entry name" value="DCP1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16741">
        <property type="entry name" value="mRNA_decap_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0866">Nonsense-mediated mRNA decay</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="mRNA-decapping enzyme C-terminal" evidence="6">
        <location>
            <begin position="423"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF16741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAG5074055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="461" mass="50918" checksum="E9BF9F6C90F25C55" modified="2022-05-25" version="1">MGDLTEIKMNMAALKRVDPYIKDILETATHVALYKFNAENNEWEKTDIEGALLNTNNLVEPVTQRLDLELQEPFLLYRNSKYNIYGIWFYDKDECIRIAAILKQLVKHSDENLKKVNTSLKNKKQVINKASDSFNNVDIFSMLSKAQENFNTSRESNGNHDINLNSDGISDDINTFSHSGTGITTGGMFDGTSQSVVDFFAKAKHQQPPGNVHVAVEKPISLSHLMSHPAAHTLEHIEKQQRSITPQSTGIPSIVPPSTVPIAVNLMKNGTPSSKTKKHACSDSGLAASSQMLQHPKSSASNDVIVAKSFHRIQSPLTGGPTNNTIINHNTPGQNYRHSIFSMDTPLDCNKVIKNEKPSAGKTLTDISALPLGFSSLDLDDKSIESEEAQVGIRGFGTNAPALMPPVMFSATSPSESTRPIIEPLTRNQLLQAFNYLLKNDSDFMMKLHDAYVKSFSEIYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H0A5</accession>
    <name>A0A8J2H0A5_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Similar to MEOX1: Homeobox protein MOX-1 (Pan troglodytes)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HICCMSTLAB_LOCUS1794</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001116">
        <property type="protein sequence ID" value="CAG5075655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H0A5"/>
    <dbReference type="OrthoDB" id="6159439at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020479">
        <property type="entry name" value="HD_metazoa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042634">
        <property type="entry name" value="MOX-1/MOX-2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24328:SF7">
        <property type="entry name" value="BUTTONLESS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24328">
        <property type="entry name" value="HOMEOBOX PROTEIN MOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00024">
        <property type="entry name" value="HOMEOBOX"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0010">Activator</keyword>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="4 9 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 9 10" id="KW-0371">Homeobox</keyword>
    <keyword evidence="8 9 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Homeobox" evidence="11">
        <location>
            <begin position="168"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="9">
        <location>
            <begin position="170"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAG5075655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="239" mass="28164" checksum="8D44B39A03FC9702" modified="2022-05-25" version="1">MEYLSKNYDGNYQEISTPTFTTENSDNFFNHQFIQNSNYFYGYQVNNFNNYYFQNGDENFSYEEKTINSEMKSNSWENSSGLLSIPREENSCNYSTINGTEIPADQIEHIEDTQEFEDLAVKSSTSEYGKLSLPSSSVLHPTSYFLIDILIAITGTKKKDKKLSPSSNKLRKERTAFNKTQIKQLEIEFLRSNYLTRLRRYEIAVTLDLTERQVKVWFQNRRMKWKRTKNTIIYPPVIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H1X5</accession>
    <name>A0A8J2H1X5_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Similar to R1A1-element\ORF1: Uncharacterized 50 kDa protein in type I retrotransposable element R1DM (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HICCMSTLAB_LOCUS799</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001114">
        <property type="protein sequence ID" value="CAG5074027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H1X5"/>
    <dbReference type="OrthoDB" id="7554612at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="269"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="18"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG5074027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="456" mass="49387" checksum="E0458E8EDC23C112" modified="2022-05-25" version="1" fragment="single">MVALMPVQAEPNVGNQKTPEEEPFHLVDRKEKRKKKKKKQVEEAVDQAATAKPAGPGSGTTEQGPAAGRTRAAKEDRRPRRKQRPEAVLIKPGKTQSCGDVLRALRSGLHPEELGLEVKAVRTASKGGLLIEFEGSVKDRSALGSKITEVAGGDVEVRHLYPTATVVIDGMDAATTVEEVRAALGEAAGGIADGLNVTITKPNKWGAVRAFIEAELGAAATLETLGKVKVGWTVCRIRRRERLDRCYRCQGLGHLAGSCKAKEDRSGCCWRCGEADHQSKACTKPPSCHLCAAVGNGRASDHVAGSGRCATYREVLQINLHRCKLALDLLYARNRDNGMDIVLVSEQYHSVSGPNWYCDPTGTAAVWVPDRSRLSVRNSGSRDGIVWVVTPAVTFVSVRGNPTTVPERQMKQTGWKVSLLDESAFQNAVSDRIDTLPDLLAESRENLESLVGQTME</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H2Z6</accession>
    <name>A0A8J2H2Z6_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Peptidyl-prolyl cis-trans isomerase</fullName>
            <ecNumber evidence="5">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HICCMSTLAB_LOCUS243</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 10 11">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="5"/>
    <dbReference type="EMBL" id="CAJNRD030001114">
        <property type="protein sequence ID" value="CAG5073248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H2Z6"/>
    <dbReference type="OrthoDB" id="2530521at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051370">
        <property type="entry name" value="PPIase_Pin1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000297">
        <property type="entry name" value="PPIase_PpiC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10657">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10657:SF4">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00639">
        <property type="entry name" value="Rotamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54534">
        <property type="entry name" value="FKBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50198">
        <property type="entry name" value="PPIC_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4 5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4 5" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PpiC" evidence="7">
        <location>
            <begin position="54"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="54"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG5073248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="128" mass="13806" checksum="FDBB6C7C3E8A02E5" modified="2022-05-25" version="1">MSNEELPKGWEKRLSRSTESQWDVPIKPAQPCDNGDEPEEVQCSHILVKHANSRRPDCSSAKRGGDLGPFGRGAMQKPFEQAAFALKVGELSTPVDTDSEFPEFPIVGGGCLRALCQISESCCSGAIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H356</accession>
    <name>A0A8J2H356_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Similar to rnaset2: Ribonuclease T2 (Danio rerio)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HICCMSTLAB_LOCUS543</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the RNase T2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001114">
        <property type="protein sequence ID" value="CAG5073652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H356"/>
    <dbReference type="OrthoDB" id="435754at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033897">
        <property type="term" value="F:ribonuclease T2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006401">
        <property type="term" value="P:RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01061">
        <property type="entry name" value="RNase_T2_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.730.10">
        <property type="entry name" value="Ribonuclease T2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033697">
        <property type="entry name" value="Ribonuclease_T2_eukaryotic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001568">
        <property type="entry name" value="RNase_T2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036430">
        <property type="entry name" value="RNase_T2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018188">
        <property type="entry name" value="RNase_T2_His_AS_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033130">
        <property type="entry name" value="RNase_T2_His_AS_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11240">
        <property type="entry name" value="RIBONUCLEASE T2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11240:SF22">
        <property type="entry name" value="RIBONUCLEASE T2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00445">
        <property type="entry name" value="Ribonuclease_T2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55895">
        <property type="entry name" value="Ribonuclease Rh-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00530">
        <property type="entry name" value="RNASE_T2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00531">
        <property type="entry name" value="RNASE_T2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" evidence="3">
        <location>
            <position position="129"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="182"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR633697-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAG5073652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="313" mass="36134" checksum="E831159F5425210B" modified="2022-05-25" version="1">MNCNSSAKFDLEQLAQISADLDAKFIGAGAKNNTSSNISKKTLELFDKYDVQGAFKSNNITIGNEKKKRTRISKIKSCDEYASKRNNISMDFDTLVFTLSWPPTVCYKYLKSTRNASWKFPLKTQWSIHGLWPSRIARRAPDFCNCTRKYNPAEIETLMPELEKKWTNVLNQSDPHYLWNHEWSKHGTCASTVDSLNTQFKYFNQTLELFDKYNISSVLSKNEIELEGTYKQIEILEAFEKSLGKQIGNNCIVHYVNDRTRKYFLSSVHLCFDKSFNLIDCIKNKHFPTNCPSPLSISAEVEYSTMEEIINLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H3D7</accession>
    <name>A0A8J2H3D7_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Similar to PPFIBP1: Liprin-beta-1 (Homo sapiens)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HICCMSTLAB_LOCUS953</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the liprin family. Liprin-beta subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001114">
        <property type="protein sequence ID" value="CAG5074190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H3D7"/>
    <dbReference type="OrthoDB" id="6516566at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048786">
        <property type="term" value="C:presynaptic active zone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007528">
        <property type="term" value="P:neuromuscular junction development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09563">
        <property type="entry name" value="SAM_liprin-beta1_2_repeat1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09566">
        <property type="entry name" value="SAM_liprin-beta1_2_repeat2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09569">
        <property type="entry name" value="SAM_liprin-beta1_2_repeat3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058914">
        <property type="entry name" value="LIPB1/2_CC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037617">
        <property type="entry name" value="LIPB1/2_SAM_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037618">
        <property type="entry name" value="LIPB1/2_SAM_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037619">
        <property type="entry name" value="LIPB1/2_SAM_3rd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029515">
        <property type="entry name" value="Liprin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12587:SF14">
        <property type="entry name" value="AT31531P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12587">
        <property type="entry name" value="LAR INTERACTING PROTEIN LIP -RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26022">
        <property type="entry name" value="CC_Liprin_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00536">
        <property type="entry name" value="SAM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07647">
        <property type="entry name" value="SAM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00454">
        <property type="entry name" value="SAM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50105">
        <property type="entry name" value="SAM_DOMAIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="SAM" evidence="6">
        <location>
            <begin position="517"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="domain" description="SAM" evidence="6">
        <location>
            <begin position="591"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="220"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="391"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="282"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="15"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="236"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="415"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAG5074190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="819" mass="92126" checksum="41AB254AA62AB5B7" modified="2022-05-25" version="1">MGKGEDSNGSEDGDSSSGSNKYNSSSTTEASKMLEAALLQMDGIISGTCADTTDGSHSLCDWREMENWNGKDLHPIIEEEDKSKDSISESDSSTIKNWKNHWRRQLYSQNNADEDEDFQDYDEDIDEEYSSQTSTESLKKCDDSFRSSYFSSIKSAKSKKKITPESVAKEINAIKRCNGSKTLNKQYKKNYNSARLINNSRLINLNTCGANIGNGGAGSNNCASGSLDRRRKRLRNRNERDQRAKSQSDLCYERDRVTPVHYCSLQQFHCQYSSNPCINCFNNNTEERLRKLENDRAGLNMEVAVLSEQVDAQSNKIMELEHLLQEKKNCLRQLDDALQQEILSKSALETQKLELLTSLSEMKLKQASLEHENMTLRNSASLANGEKFSRHTGQYSSLPRPPTVPKKGVAFGKKLSGTSTPQSQSQSSLPTIIYNPGLLSQSQMQLQSQSISPPVNVRGIISSRCLSAPHLAEEDKIIANESVNSPQKQSQRQHEQFYNKQEEIESVSVISKSLKDLSMEEVEYWLAQLGLECYSGELRRWGATGPKLLDSTPHQIEKELDIKNSLHRKKLMYAIECERCNGVGFLGSEKMDNSAVLRWLDDIGLPQHKESFQSAKVDGRVLHRLTTEDLLNLGVNAQLHAASLRRGIQVLRELNFEFDNLERRSLTGDGADGSNIALWTNHRVMEWLRVVDLAEYAPNLRGSGVHGGLIVHEGRFTTELLAAILSIPPSKTLLRRHLTTHFNDILGRDVVQHKREIENTLGFVPLTLTARLKVAKKSQFTLKRKKSKSEVDYANLVCPLEASPPDLEIVEHRKIIGCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H3L6</accession>
    <name>A0A8J2H3L6_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ubiquitin-like modifier-activating enzyme 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HICCMSTLAB_LOCUS1326</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="1">E1-like enzyme which activates UFM1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ubiquitin-activating E1 family. UBA5 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001116">
        <property type="protein sequence ID" value="CAG5075172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H3L6"/>
    <dbReference type="OrthoDB" id="206053at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071566">
        <property type="term" value="F:UFM1 activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071569">
        <property type="term" value="P:protein ufmylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00757">
        <property type="entry name" value="ThiF_MoeB_HesA_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000066">
        <property type="entry name" value="Putative ubiquitin-like modifier-activating enzyme 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029752">
        <property type="entry name" value="D-isomer_DH_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953">
        <property type="entry name" value="UBIQUITIN-ACTIVATING ENZYME E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953:SF9">
        <property type="entry name" value="UBIQUITIN-LIKE MODIFIER-ACTIVATING ENZYME 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="Activating enzymes of the ubiquitin-like proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00065">
        <property type="entry name" value="D_2_HYDROXYACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="THIF-type NAD/FAD binding fold" evidence="9">
        <location>
            <begin position="44"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAG5075172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="386" mass="42590" checksum="1972208A5ECC2507" modified="2022-05-25" version="1">MSSVEELTEKIRQLELELSQERNKNVSRKKIEVLSSEVVDTNPYSRLMALKRMGIVDNYEKIRTLTVAVVGVGGVGSVTAEMLTRCGIGKLVLFDYDKVELANMNRLFFQPHQVGLSKVNAAARTLTTINPDVFVETNDYNITTVDHFENFMKAISTGSLTNGPVDLVLSCVDNFEARMAINTACNELNLKWFESGVSENAVSGHIQFIVPGESACFACAPPLVVASKIDEKTLKREGVCAASLPTTMGIVAGFLTQNALKFLLNFGSTSFYLGYNAMEDFFPSMVLRPNPNCDDRYCRQRQQEFQALPKEEIAVEAVEEAPVHEDNDWGISLIDETADVAEEDNVRGLCPGLRQAYVVPDAHAHENVVDASALSLEELMATMKTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H3R9</accession>
    <name>A0A8J2H3R9_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ZP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HICCMSTLAB_LOCUS2054</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001116">
        <property type="protein sequence ID" value="CAG5076073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H3R9"/>
    <dbReference type="OrthoDB" id="10062424at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056953">
        <property type="entry name" value="CUT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001507">
        <property type="entry name" value="ZP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46560">
        <property type="entry name" value="CYPHER, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46560:SF1">
        <property type="entry name" value="MINIATURE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25057">
        <property type="entry name" value="CUT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00241">
        <property type="entry name" value="ZP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51034">
        <property type="entry name" value="ZP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035196930" description="ZP domain-containing protein" evidence="3">
        <location>
            <begin position="19"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="482"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="domain" description="ZP" evidence="4">
        <location>
            <begin position="45"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="347"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="542"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="354"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="542"/>
            <end position="553"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAG5076073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="561" mass="62447" checksum="ADAB1C0C00B2B1FB" modified="2022-05-25" version="1">MRGVWKLLLIIIYTMVGAKISSGNGDIWPLERPEGMPSIQSLEVMCGKDHMDVHLSFSQPFDGIVSSKGQHADPRCVYVPPSTSQTFFSFRIAYARCGTKPDMHGQFYENTVVVQYDKDLLEVWDEAKRLRCEWFNDYEKTASKPPMVIADLDVIQLDFRGDNVDCWMEIQHGKGPWAPPVSGIVPLGSTLTLVVAINDYRGEFDMRVKSCVASDGGGHTIQLSDELGCVLRPKMISRFLKARGADDRATVITYAFFHAFKFPDALSVHIKCKVEICRHGCLDHCQLTGAAGHYIQDRKDHPVRNLYPQTTQTTITHEDDTSLYDDIIQNGDEMASIGGQFLGVEKSAPKAQAQIGNRNTPQVQEESEEHNQETPDLAHSFLDPPRVTRYEGEEQFPHGPRNLEEDSKITPIMSNGSRRRRSVKVLDRKARSADVGVSGIYEVISEADLAFSPDAHAEAVTVFQGRIREEVVYGICLPMPGFSALFVIVALSAVVSALVAGAMLHRLQVQREVVGSPKNRVAVAVNANGWLPYGLLRVRGNERAQEDRHKQEDTGNPIEQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H3Z7</accession>
    <name>A0A8J2H3Z7_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">THAP-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HICCMSTLAB_LOCUS2311</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001117">
        <property type="protein sequence ID" value="CAG5076886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H3Z7"/>
    <dbReference type="OrthoDB" id="7555211at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.210.20">
        <property type="entry name" value="THAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026516">
        <property type="entry name" value="THAP1/10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006612">
        <property type="entry name" value="THAP_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038441">
        <property type="entry name" value="THAP_Znf_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46600">
        <property type="entry name" value="THAP DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46600:SF11">
        <property type="entry name" value="THAP DOMAIN-CONTAINING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05485">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00692">
        <property type="entry name" value="DM3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00980">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50950">
        <property type="entry name" value="ZF_THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="THAP-type" evidence="7">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="177"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG5076886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="212" mass="24043" checksum="6C7914B5518715EF" modified="2022-05-25" version="1">MVKLCFLCDRKPSKADKISFHKFPKDEIARQKWLDICGLTSEDDVSRICICSMHFTAADMISCSSGIKKSFLKSGAVPTKLLSNPLVIKEIDEAAKAAKKRNDPDITLQSSVEELIDELINEIGDLDDNIEVPKKQRIFYRPRYISEITLEDLSTPSKAERVLKLIKTTDLRKSKQIKSLQDQRRQLNLKIKSLKALIAQLQGKDPDALEEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H470</accession>
    <name>A0A8J2H470_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS2238</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001117">
        <property type="protein sequence ID" value="CAG5076635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H470"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5076635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="61" mass="6802" checksum="3950D4403218F254" modified="2022-05-25" version="1">MENIGSQPKLLTSLFAASFRKNLLINYPLTRHIAVPVQETINKILRPSLSITSGLQQVPEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H5Z1</accession>
    <name>A0A8J2H5Z1_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HICCMSTLAB_LOCUS2494</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001117">
        <property type="protein sequence ID" value="CAG5077545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H5Z1"/>
    <dbReference type="OrthoDB" id="10338906at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052192">
        <property type="entry name" value="Insect_Ionotropic_Sensory_Rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42643">
        <property type="entry name" value="IONOTROPIC RECEPTOR 20A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42643:SF30">
        <property type="entry name" value="IONOTROPIC RECEPTOR 40A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035309923" evidence="9">
        <location>
            <begin position="17"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="336"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="382"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="573"/>
            <end position="595"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAG5077545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="603" mass="70948" checksum="ADBC39127167CDAA" modified="2022-05-25" version="1">MWQKIILCCLIVTSMGEIRMDIYDMKEDSKERLKSDARELVETCLTNNSSTIMISKKLFDYNWNPDKNPLMIIDNVFKKQITGFLPAYPTYVLFFQSIESLKEIINHLKKSTLWSIKSPFVIVETESRCKNTRRVLEFMWKQDLLSVYYLCNQKYFTVILTLNPYASYAPKPWALVEEFGGSNKNMTLYSLQYSKDPELCKSITFKKTDHLESVNIKLTLFSLNRTTIMQISHGDHVKKLIKLKLMNIFQIPAYINTTPTLEIIQYPNSSQLTQGFVQQLVDQTHDVHGSLMPITETDYKYVDVIADYFHEHEFFILTKKADFLTVISEVSNDVDFVVMTIVVFVMFTIAMVLINREDICGALMDSVKLVVNMGLESPLNRLAMKLILFCGFLFAFLIVPNFQGHVFAILSKPVRRNVETLEDLYENKFHVYHYDKVGRDIINKQLWVTNEDKKYLHPRNSLEMQECFKNAKTNVTIACIHSKRRLRSFSIDNTDVYVSKTPIFKKQFVHWARKNWPLKHKFDKMALKTSEPGLESNLRSVRWYERLYKTKKMKNRIEAREEYDKFDYDELVFIYYFVGFLSAFGAMVFVIKIILARWIRIHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H603</accession>
    <name>A0A8J2H603_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Similar to e2f7: Transcription factor E2F7 (Xenopus tropicalis)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HICCMSTLAB_LOCUS2524</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the E2F/DP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001117">
        <property type="protein sequence ID" value="CAG5077657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H603"/>
    <dbReference type="OrthoDB" id="5318at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090575">
        <property type="term" value="C:RNA polymerase II transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000073">
        <property type="entry name" value="E2F transcription factor 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015633">
        <property type="entry name" value="E2F"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003316">
        <property type="entry name" value="E2F_WHTH_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12081">
        <property type="entry name" value="TRANSCRIPTION FACTOR E2F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12081:SF7">
        <property type="entry name" value="TRANSCRIPTION FACTOR EFL-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02319">
        <property type="entry name" value="WHD_E2F_TDP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01372">
        <property type="entry name" value="E2F_TDP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0678">Repressor</keyword>
    <keyword evidence="6 9" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 9" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="E2F/DP family winged-helix DNA-binding" evidence="11">
        <location>
            <begin position="99"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="E2F/DP family winged-helix DNA-binding" evidence="11">
        <location>
            <begin position="232"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM01372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAG5077657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="684" mass="76218" checksum="851F4C317D917E30" modified="2022-05-25" version="1">MEIGNRTPERKILGELSNTKPEPISPTANLRLLTSLASNLKSVADNNYCLNKVQNNSNNNIININNSNINIINHNNNYITESSPIASGSIGNGFKILPRKQKSLGLLCNKFLNMYPLNLDQETREISLDKTAKDLGTEKRRIYDIINVLESLDMASKAGKNRYLWHGQSNLTATLVRLKSTAIRLGLREQIQEIQKNFRAYTNDNDDSCNELMMSLEEPVDEETYYSDTAIKEDKSLGAMCQKFVMLFLVSMKNGVINLEIAAKVLILDNADNQTEMMGDTGSRSRFKTKVRRLYDIANVLTAIGLIKKIYLFDRALKKPIFKYFGPDVESTESFDTDTPVSKIHSSSIGMSTPDKCLTPHSYHSYAATSANFGTSKAFIKNCYSTPTIDKRKLRKRKLFDSDTASFSRTNSLPNLDNKSRSLERLDDSILRVAEMELEKLNSSEEPKPKACTKLLTRYKSDSCIKNPPLLPDKLIKTDSAHPIVKLEPEVNNQSLVVQSANAESVYKNLKVSQMAIRTGQLNKINPTASTIIKTKPVHKIMKLIPIGSISSLQDPISAGTTKILIPKSMSSVVDNNNTKSTCYKLSQPKTTRVINLTKIDPNKLIPIKRSDIKFSLAEQTYSKPIVMQQQVQPADNSVNLGNNSGYAMLTRIQAATVSPGDTFKAIKVGNTLQLVPINSSNDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H6C9</accession>
    <name>A0A8J2H6C9_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS2647</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001117">
        <property type="protein sequence ID" value="CAG5078109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H6C9"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5078109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="193" mass="21872" checksum="6B47BFC01EAD97D2" modified="2022-05-25" version="1">MGPGSIPVYTNEYFQYLSVLCCSAQKNKTSPTIKVYSLPKSLVTLTRVRNFSKFKCVFALYSYNIIQQLPYESEPDPLEVREISRDHCYKAYQLGVWSPISTKKLEGIVKLACALESGRYVARDIVQPKKSTSLKKREHHSSFLRHLFLLISQHTFSCPCRATEGVCAINFSSSGTPEWPRSGSQDKTQNYGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H6E9</accession>
    <name>A0A8J2H6E9_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">LYR motif-containing protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HICCMSTLAB_LOCUS2598</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Involved in efficient integration of the N-module into mitochondrial respiratory chain complex I.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the complex I LYR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001117">
        <property type="protein sequence ID" value="CAG5077946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H6E9"/>
    <dbReference type="OrthoDB" id="74240at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd20262">
        <property type="entry name" value="Complex1_LYR_LYRM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008011">
        <property type="entry name" value="Complex1_LYR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045293">
        <property type="entry name" value="Complex1_LYR_LYRM2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13675">
        <property type="entry name" value="LYR MOTIF-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13675:SF0">
        <property type="entry name" value="LYR MOTIF-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05347">
        <property type="entry name" value="Complex1_LYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Complex 1 LYR protein" evidence="7">
        <location>
            <begin position="19"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00026235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00044735"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG5077946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="105" mass="12375" checksum="2B7FAF64D51B5BD7" modified="2022-05-25" version="1">MLNKISSSSMNLKQFLVRQQVITLYRNILRTIRKIPGKEDQNYFLDWARSEFKANKSITDEFAIKSLIVHGENSMKELEKNLNYSNDNQINYENNTSRARNNQSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H6G4</accession>
    <name>A0A8J2H6G4_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS2708</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001117">
        <property type="protein sequence ID" value="CAG5078325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H6G4"/>
    <dbReference type="OrthoDB" id="2150267at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="Periplasmic binding protein-like I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5078325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="129" mass="14392" checksum="8B40080C50082648" modified="2022-05-25" version="1">MIGGIGGIDYRQRQKQPQLCCLLLLRLRGAALGIGIVLCLDAILLCGGQKPINLGGVKRRDVYIAGFFPYGRHVPESHIGRGVMPSVKLAVDHINDNPAILRNYRLHMWWNDTESPICGLNQFLVKTTW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H6L2</accession>
    <name>A0A8J2H6L2_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Similar to Gabbr1: Gamma-aminobutyric acid type B receptor subunit 1 (Mus musculus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HICCMSTLAB_LOCUS2814</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001117">
        <property type="protein sequence ID" value="CAG5078694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H6L2"/>
    <dbReference type="OrthoDB" id="17569at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038039">
        <property type="term" value="C:G protein-coupled receptor heterodimeric complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004965">
        <property type="term" value="F:G protein-coupled GABA receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007214">
        <property type="term" value="P:gamma-aminobutyric acid signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06366">
        <property type="entry name" value="PBP1_GABAb_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2300:FF:000056">
        <property type="entry name" value="Gamma-aminobutyric acid type B receptor subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001828">
        <property type="entry name" value="ANF_lig-bd_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002455">
        <property type="entry name" value="GPCR3_GABA-B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017978">
        <property type="entry name" value="GPCR_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10519">
        <property type="entry name" value="GABA-B RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10519:SF77">
        <property type="entry name" value="GAMMA-AMINOBUTYRIC ACID TYPE B RECEPTOR SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00003">
        <property type="entry name" value="7tm_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01094">
        <property type="entry name" value="ANF_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01177">
        <property type="entry name" value="GABAB1RECPTR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01176">
        <property type="entry name" value="GABABRECEPTR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="Periplasmic binding protein-like I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50259">
        <property type="entry name" value="G_PROTEIN_RECEP_F3_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 13" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035326090" evidence="11">
        <location>
            <begin position="18"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="457"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="495"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="534"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="588"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="660"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 3 profile" evidence="12">
        <location>
            <begin position="465"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="707"/>
            <end position="741"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAG5078694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="810" mass="90481" checksum="38CA756114197EDB" modified="2022-05-25" version="1">MKMELFVIFALIAAISGKLPPSDDNILHIGGIFPIGGEGGWQGGQACMPAANLALIDVNREKNLLPGFELKLHSNDSECEPGLGASVMYNLLYNAPQKLMLLAGCSTVCTTVAEASKMWNLVVLCYGASSPALSDRNRFPTLFRTHPSATVHNPTRIKLFQKFGWSRVAILQQAEEVFISTVEDLETRCKEAGIEIVTRQSFLSDPADAVRNLRRQDARIIVGLFYVVAARRVLCEVYHQNLYGKSYVWFFIGWYEDNWFEANLDKEGITCTKEQMRQAAEGHMTTEALMWNQNNDTTISGMTSEDFRQRLNKQLKEDGYDVDNNRYPEGYQEAPLAYDAVWSVALAFNKTMDKLSKSGKSLKNFTYTDKEIADEIYSAINSTQFLGVSGYVAFSSQGDRIALTQIEQVIDGNYVKLGYYDTQSDNLTWKNRERWIGSKVPQDRTIVRKVLRTVSTPLFACMSACSALGIIIAILLIFFNVWFRHRRVVLSSHPVCNTIMLVGVIICFISVFLLGLDGRFVSPGEYEHVCQARAWMLSIGFTLGFGAMFSKVWRVHRLTTKTKADQAKLFIAKQKVSSVQKNVQPWKLYTMVSALLAIDVIILGAWQGLDPLQRTIEVFPLEASPHGDDDAKISPELEHCESQNNSIWLGLVYGYKGIDASFTFVALAIIFCCFLSMALIFVPKVIEVIRHPRDKAESKYNPDMGMSKEDEERYQKLVNENDELQRLIAQKEEKIKVLKQRLAERDVAKGVAFAPGGAAAGGNVPKDSLIVADFVTGEGTSDSAIGGGISVYTRSSRASASDFEFSESYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H7E5</accession>
    <name>A0A8J2H7E5_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS3254</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5081335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H7E5"/>
    <dbReference type="OrthoDB" id="6352355at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5081335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="77" mass="8508" checksum="BE12E9F024DF9238" modified="2022-05-25" version="1">MAFTKQEILHIRENREDTNHFHELVQALAQGNTRQTNGDAGHNHNGYPTPATSAAHNALNPMNNLNGINAQATYDTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H7U3</accession>
    <name>A0A8J2H7U3_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Similar to Myef2: Myelin expression factor 2 (Mus musculus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HICCMSTLAB_LOCUS3743</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5083140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H7U3"/>
    <dbReference type="OrthoDB" id="610462at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000531">
        <property type="entry name" value="Myelin expression factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050374">
        <property type="entry name" value="RRT5_SRSF_SR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23003:SF3">
        <property type="entry name" value="FI21236P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23003">
        <property type="entry name" value="RNA RECOGNITION MOTIF RRM DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="58"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="208"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="495"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="142"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="473"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="142"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="473"/>
            <end position="490"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAG5083140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="549" mass="59634" checksum="4376DD41C2880C15" modified="2022-05-25" version="1">MIKADEAQNQNEDRERSRERDRNRRSDRQRLNSSSRDRSRERSGAGGGGSGGRRISERRIYVSNIPYDFRWQDLKDLFRTEVGKVAHVELFTDENDKPRGCGIVEFEDSDSVKVAVEKMHRFDIKGRKLVVKEDYDVERDKYGRLQSSRDHDRSRDDRFRDSSRSNVGRGSLVSSGSVLGSNGDKFGNTYGLSTQFLESLGINGPLVTRVFVANLDYKVDEKKLLEVFKLAGKVLHVELGKDKDGKSRGFGVVEYDHPVESVQAISMLHNQQLYDRRMTVRLDRANDPDLPPKLPEGLKSIGMGLGAGGNRLMDVARNIPSVAANTPVVNSIAAPVLATSAFGGGLNNVVPAQLASALSNSNAAALQASLASGLGNNLATSSLLNSSLTSELASNLNNFTGNVSGLSSLQASLAASNQGSNSFGQRGLGKLDGDVGGFGGSSFGNSNYGGSRGDFDAFNRDSDRMANANAVFSANQSQQSNANRQSSNGARPMSDTIVIANLPPSTTWQMLRDKCQEIGEVKFAEMRGNDIGMVRFASEWDAERAVCIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H831</accession>
    <name>A0A8J2H831_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to Plpp7: Inactive phospholipid phosphatase 7 (Rattus norvegicus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS3560</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5082434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H831"/>
    <dbReference type="OrthoDB" id="10266771at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042392">
        <property type="term" value="F:sphingosine-1-phosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03391">
        <property type="entry name" value="PAP2_containing_2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.144.10">
        <property type="entry name" value="Phosphatidic acid phosphatase type 2/haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000326">
        <property type="entry name" value="PAP2/HPO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="PAP2/HPO_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14969:SF13">
        <property type="entry name" value="AT30094P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14969">
        <property type="entry name" value="SPHINGOSINE-1-PHOSPHATE PHOSPHOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01569">
        <property type="entry name" value="PAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00014">
        <property type="entry name" value="acidPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="Acid phosphatase/Vanadium-dependent haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="149"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphatidic acid phosphatase type 2/haloperoxidase" evidence="2">
        <location>
            <begin position="56"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5082434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="194" mass="22199" checksum="3DE54DF964C847CA" modified="2022-05-25" version="1">MDVYLTNAFVKKVENFMPMKQLKMHYRALEISAHTIPWLAGWLAFIWIISSKDLYQMQVNLFIGLLIDIVNVAVIKAATRRRRPSKNDDPFGMGPDKYSFPSGHASRVAFLTYFFINLWPVPIMFVPSLLAWSTAVCLSRVLLKRHYILDVLGGVCLGIFQGILLSLIYLERDTCISLISWLTDEKLEGGEFHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H852</accession>
    <name>A0A8J2H852_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to RDH13: Retinol dehydrogenase 13 (Homo sapiens)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS3936</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5083814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H852"/>
    <dbReference type="OrthoDB" id="191139at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157:SF31">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5083814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="325" mass="36019" checksum="CCBED3B284F90FDD" modified="2022-05-25" version="1">MGIKLPKSAVFGSAVCTLVGTLYIIKDKLGGRTYEGTEKLTDKVIIVTGANTGIGKEVTRDLAKREAKIVMACRDLGKCEKTRKEIVLETKNKFIYCRLCDLASQSSIREFVKAFNQEHDRLDILINNAGVMRCPKSVTKDGIETQLGVNHMGHFLLTNLLLDKLKSSAPSRVVVVASTAHRRGKIKIEDLNSEQSYDPGDAYAQSKLANVLFAKELAKKLAGTGVAVNSVHPGLVDTEIMRHMSFTKSTVASLMIKPFFWLFIKTPKQGAQAVLNAALNPELQKLSGVYLSQFDIIKEEDETEEVKNTKLAEWLWVTSTKWSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H9C1</accession>
    <name>A0A8J2H9C1_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 18">Alkylglycerone-phosphate synthase</fullName>
            <shortName evidence="18">Alkyl-DHAP synthase</shortName>
            <ecNumber evidence="7 18">2.5.1.26</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">HICCMSTLAB_LOCUS4861</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="18">Catalyzes the exchange of an acyl for a long-chain alkyl group and the formation of the ether bond in the biosynthesis of ether phospholipids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>a long chain fatty alcohol + a 1-acylglycerone 3-phosphate = a 1-O-alkylglycerone 3-phosphate + a long-chain fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:36171"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17135"/>
            <dbReference type="ChEBI" id="CHEBI:57534"/>
            <dbReference type="ChEBI" id="CHEBI:57560"/>
            <dbReference type="ChEBI" id="CHEBI:73315"/>
            <dbReference type="EC" id="2.5.1.26"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 16 18">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 18">Glycerolipid metabolism; ether lipid biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Lipid metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6 18">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 18">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 18">Belongs to the FAD-binding oxidoreductase/transferase type 4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.26" evidence="7 18"/>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5088473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H9C1"/>
    <dbReference type="OrthoDB" id="7786253at2759"/>
    <dbReference type="UniPathway" id="UPA00781"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008609">
        <property type="term" value="F:alkylglycerone-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008611">
        <property type="term" value="P:ether lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.43.10:FF:000003">
        <property type="entry name" value="Alkylglycerone-phosphate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.650">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="entry name" value="Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.45.10">
        <property type="entry name" value="Vanillyl-alcohol Oxidase, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025650">
        <property type="entry name" value="Alkyl-DHAP_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004113">
        <property type="entry name" value="FAD-bd_oxidored_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016164">
        <property type="entry name" value="FAD-linked_Oxase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016171">
        <property type="entry name" value="Vanillyl_alc_oxidase_C-sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46568">
        <property type="entry name" value="ALKYLDIHYDROXYACETONEPHOSPHATE SYNTHASE, PEROXISOMAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46568:SF1">
        <property type="entry name" value="ALKYLDIHYDROXYACETONEPHOSPHATE SYNTHASE, PEROXISOMAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02913">
        <property type="entry name" value="FAD-oxidase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55103">
        <property type="entry name" value="FAD-linked oxidases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 16 18" id="KW-0274">FAD</keyword>
    <keyword evidence="9 18" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8 18" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="12 18" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="13 18" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 18" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="20">
        <location>
            <begin position="143"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="14">
        <location>
            <position position="523"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="175"/>
            <end position="181"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="257"/>
            <end position="260"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="314"/>
            <end position="320"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="461"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Important for enzyme activity" evidence="17">
        <location>
            <position position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00008000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00012385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR625650-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR625650-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR625650-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR625650-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU363113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="CAG5088473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="610" mass="68455" checksum="8EBA36666568C34E" modified="2022-05-25" version="1">MSKSESNNLSDNNSRDINPTSVKSTVPKIRQELLKWNGWGYKDSEFVVKDNSIIEFTGSRYPIGNLQLPYFTQWVQEVLGVDLTKKTPSQSLPVSFPDPILSQDFLDAVKELQIAFSTDGMDRLFRAHGHTLREMILLKHGHFDRIPDIILWPKCHNDVERIIRICVKYGVACIPFGGGTSVSGAASCPTEERRTIVSLDTSQMNRILWIDRENLVACCEAGIIGQDLERELRSRGLTSGHEPDSYEFSSLGGWVATRASGMKKNTYGNIEDLVVRVRMVTGRTEDPSLTLERGAQVPRISSGPDFDHIILGSEGTLGVVTEVVFKVRPLPKIVKYGSVIFPNFESGVDAMREVARQRCQPSSIRLMDNEQFRFGQALRPDNGWTDKIMHAFKQAYVTKIKGFQWNDVCVATLLFEGYEANEVAAQEKKIYTIVKQFGGMAAGETNGERGYILTFVIAYIRDLGLEYGVLSESFETSVPWSRALSLCKNVKSRVSRDCKERGIKHYLMSCRVTQTYDAGCCIYFYLAFNYIGLHEPVETYETIEENARAEILASGGSISHHHGVGKMRAKFYPEAVGQTGVSLYRAMKEHLDPNNIFAAGNLVPNYRAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H9F9</accession>
    <name>A0A8J2H9F9_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS3995</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5084030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H9F9"/>
    <dbReference type="OrthoDB" id="7763192at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33332">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5084030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="303" mass="34709" checksum="16FD3A4A701DCC20" modified="2022-05-25" version="1" fragment="single">GIADWAKDHGLQVNLNKTKSLIIGSNSKLKSLNIDSLPPIIINNVPLPYVSQTKCLGLSLNNDLLWKNYVSQTVRKVNAALYTLKTRMNIYTTAIRKLLVTATILLLIDYCTVVLIDATADNNLKLQRALNSSIRFIYNLKRDEHITPYRRKLNWLSSGHDFQFDAAQILDYESHFLKRNISEMFFIKVFDCVNFRSDTQGHGLFADDKYIYLHFHYYQLYDAIRQITTDAQAVVDWAKDNGLEINVTKTKAMLLGSSGKLKNIQHNFLPLIVVNGISRPGVWDFTLQIHCLGIFIRQKQSVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H9G8</accession>
    <name>A0A8J2H9G8_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS4956</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5088722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H9G8"/>
    <dbReference type="OrthoDB" id="10415805at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035262315" evidence="2">
        <location>
            <begin position="20"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="300"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="332"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="386"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="438"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="453"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="466"/>
            <end position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5088722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="477" mass="53712" checksum="08FC5039C6C2748D" modified="2022-05-25" version="1">MNILIKVLIASVIVSVCQGCAVLYSNRIEKRHTKVRLSSWTVVIDRNSFALRTLDEKFVDYGTLIHPQAVLTLNSTVLYKPFRNYKCLGGCGDFQPSALSIKNCQIRDFGRIFSGHLDANKHANPSNTFAIIILKTPFDLGNKISVINVSSKPINSNRCYFYGVTALSIINKNNLRERNVSPVSPYRAITVNGSAHSYKCGGVNYTQVVEDTYLKVEKSEIVFKYNYRATPVVCQNNKTNKYEQVGFLSLYADTRKPYAQQRREVFIGTTFGHKRIYQILNKYLNYSSILKSPSIQNSTHIPKPAPIENCTHIPKHNNTQNSTHIPKPAPIKNSTHIPKQNNTQNPTHISKQNHNKTPNISKQNHNKTTNISKQNSTHISKKNHNKTTNISNQNHTQNSTHISKDKSTTDNSTEIDKTTVSNVKMSEQKNGKNSAHISKQKKIKKSTHISKHKAPDNSTHVDKTTVSKVETATTKTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H9S9</accession>
    <name>A0A8J2H9S9_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS5193</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5089323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H9S9"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5089323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="273" mass="30700" checksum="5665EA00449AEEBC" modified="2022-05-25" version="1">MATNFNKRQLLVNTLNRPTKPELRPMAAVAVRMHCIKYILQDKRGNACHTGSGGGSPLSPGWRTTWICSLVTSNCSLGDTSTKPPSSSRLVRTAPFATELTVDLMGLLLFCKLPFLGSLRLKKKLLSIRLYSPIMDRTYNNKNRSDKFPTNTPIQSWRKSNHIFNIRAKSISTHDARPTRKYKVNKQATNISRWFPIRGNSSLSAVIIASDPPNWNIIKIIINYLLNYPDQGPKNGPRHCCNCCGINNEDKTRPFSGDIFNGTAARMRHVTKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HA49</accession>
    <name>A0A8J2HA49_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Protein Wnt</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HICCMSTLAB_LOCUS4878</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Ligand for members of the frizzled family of seven transmembrane receptors.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Secreted</location>
            <location evidence="1 8">Extracellular space</location>
            <location evidence="1 8">Extracellular matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the Wnt family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5088514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HA49"/>
    <dbReference type="OrthoDB" id="5945655at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005102">
        <property type="term" value="F:signaling receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016055">
        <property type="term" value="P:Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005817">
        <property type="entry name" value="Wnt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00110">
        <property type="entry name" value="wnt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0272">Extracellular matrix</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 8" id="KW-0879">Wnt signaling pathway</keyword>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAG5088514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="126" mass="13552" checksum="F4C0D94B010EC90D" modified="2022-05-25" version="1" fragment="single">YLGLEPRLNGFESGTGGADGITQIGAGVIGPASAERNCKSSHLTIKQQGICSRSPPILQARFVDDIHFGEKLSREWSDGAEIPIKEGELSGPKGLAGQLMRKHDSEAGRRAVRSRMQRVCKCHGII</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HAD7</accession>
    <name>A0A8J2HAD7_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS5606</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5090373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HAD7"/>
    <dbReference type="OrthoDB" id="7697906at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5090373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="282" mass="32465" checksum="092050976876063A" modified="2022-05-25" version="1">MQVLIITRKSATVAAQWIIKWKEYVERKEKISSTIRAKKQNKYRVKDPVSGGDPIPDTFFHFVKYFFIERKSATNRVFYLSGERPGASAGFPVKLIENVKVICDNDTKRKTPFINNKPGRSWVEGFFKRHPNVSKRVSENLSLIRAKATEYGTREWFGKVGDYFIQALTDENDLLKIDLSRVFNTDKIGLFMNPQLNQYSRQKVAYVLKNTLESLDLEKILENEFKTCGLHPFDPNAINYGKVFKKLENSSAATPNSAEEVLNVPQDSETLRLLRSLIDDEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HBB1</accession>
    <name>A0A8J2HBB1_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ras suppressor protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HICCMSTLAB_LOCUS4768</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="4">Potentially plays a role in the Ras signal transduction pathway. Capable of suppressing v-Ras transformation in vitro.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5088229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HBB1"/>
    <dbReference type="OrthoDB" id="676979at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000034">
        <property type="entry name" value="Ras suppressor protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000159">
        <property type="entry name" value="Ras suppressor protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050216">
        <property type="entry name" value="LRR_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055414">
        <property type="entry name" value="LRR_R13L4/SHOC2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051:SF1">
        <property type="entry name" value="RAS SUPPRESSOR PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23598">
        <property type="entry name" value="LRR_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00364">
        <property type="entry name" value="LRR_BAC"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0007">Acetylation</keyword>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Disease resistance R13L4/SHOC-2-like LRR" evidence="6">
        <location>
            <begin position="120"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00053823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00069437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF23598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAG5088229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="244" mass="27728" checksum="F36A05393CB7124B" modified="2022-05-25" version="1">MNQAPVSCIPATTKMSKAKKILDEAREIQNPELDLADKNVSTFEEMPGLLNMLNITRLTLSHNKIQLVPPGLANLVNLEILNLFNNHITELPISLSQMPKLRILNVGMNRLDVLPRGFGAFPVLEVLDLTYNNLHEKNLPGNFFMMETLRALYLADNDFEYLPPEIGHLKNLQILVLRENDLIELPKEIGELTRLRELHIQGNRLTVLPPEIGNLDLVSNKAVFRMEFNPWVTPIGDQLQRLTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HC66</accession>
    <name>A0A8J2HC66_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Similar to A1CF: APOBEC1 complementation factor (Homo sapiens)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HICCMSTLAB_LOCUS6994</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5093668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HC66"/>
    <dbReference type="OrthoDB" id="3800936at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12249">
        <property type="entry name" value="RRM1_hnRNPR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21245">
        <property type="entry name" value="HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="110"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAG5093668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="588" mass="67083" checksum="8422F66AB751033D" modified="2022-05-25" version="1">MYNNQRSNNESDTGKNNGSLVNKSGKNYQYVYSINNLSNRRWDRSKNDLHDHYYAKNDEKSDLSVEESIEINKNVLEISKTSGLDITQVNGQRKLGPPKDWVGEAPSPECEVFVGNLPRNIYENKLYPIFQRAGEIFEIRLMMDFSGTNRGYCFIKYTKPEYAAKAIKELNEWPIERGKKIGVVASVNNCRLSIARLPPELDTKTFIKKIYETTESVTQVAVYSIAKSNAANKPMQKKALISYKAHIDAAMARRKLMPQRTTLFPNVELIIDWAHPSSSMHNVIEECGVMSEDGEIHISERYIEPKKHYKPKDVSAKSNKFGKGTDVLDKNLGSGRKNTIGCKSKQFFKTPHEQQRVVSNNTFKKIPLNPICKRSLSMIQENNSALRDINVNNKSAVSFNHSPVVIRSPYLSDNKENISDPYLIPAIQNLNQNLNNISLPPVFNFNGFNFNQSYQVVQKNLIMTPNLQPTFPVYQDNFCVDQNWSNFDNNRVNDSYYNQQYCSNINTNINMRCNLPGLNIVRSSIPNQCPENLNVFGNGQGHLINNQVGYRPQYDTKSFGLGKINHFPVMCADNQLFSVPRGIFKSQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HCD6</accession>
    <name>A0A8J2HCD6_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Similar to CLIP1: CAP-Gly domain-containing linker protein 1 (Homo sapiens)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HICCMSTLAB_LOCUS5388</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5089824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2130750at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035371">
        <property type="term" value="C:microtubule plus-end"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051010">
        <property type="term" value="F:microtubule plus-end binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031122">
        <property type="term" value="P:cytoplasmic microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.190">
        <property type="entry name" value="CAP Gly-rich-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036859">
        <property type="entry name" value="CAP-Gly_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000938">
        <property type="entry name" value="CAP-Gly_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18916:SF82">
        <property type="entry name" value="CAP-GLY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18916">
        <property type="entry name" value="DYNACTIN 1-RELATED MICROTUBULE-BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01302">
        <property type="entry name" value="CAP_GLY"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01052">
        <property type="entry name" value="CAP_GLY"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74924">
        <property type="entry name" value="Cap-Gly domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90257">
        <property type="entry name" value="Myosin rod fragments"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00845">
        <property type="entry name" value="CAP_GLY_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50245">
        <property type="entry name" value="CAP_GLY_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CAP-Gly" evidence="3">
        <location>
            <begin position="135"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="CAP-Gly" evidence="3">
        <location>
            <begin position="250"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="319"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="554"/>
            <end position="1012"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1048"/>
            <end position="1114"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1143"/>
            <end position="1177"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1220"/>
            <end position="1507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="20"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="320"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG5089824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="1646" mass="186223" checksum="9A1F7FFBBA30D93C" modified="2022-05-25" version="1">MSEKASGLRQPSKIGRPCCTGPPKPAVPSPSPRSSMKYQQKSLESCCAGPGQTHCSYLTLGSCLSYCTDSTPTSGNEFLSADSMEPIYENPVRRTDALRRGSDTSVVLTEDTDSFIIGDRVWVGGSKPGSIAYIGETQFAPGEWAGVVLDDPIGKNDGSVAGARYFQCAPKHGIFSRLTRLTRFPLVDAVSPRMKSPASPDSRLNKSISPSLNASMTSLSSVSQRDLKIGDRVIVSSSQGSKTGVLRFIGETEFAAGEWCGVELDDPVGKNDGSVADKRYFECRPKHGLFAPLHKVSRSPSSKRPSICVVHKPSGAALNSSLRKTSSRESLTSLSSLASTTASTATRGATRKAGLRTTTPARSSLQEMLKEKQQEIEMLRKERDLERERITKAATQADHAEQKILKLQKEYDKYREDMERAVLEAQSALEKLLEEKSQLFAQLEEEKQKSEDLLFRFEEESVNKEDIQTERAEIDVINTHNETKINELESQLTKERERVIQLEKEHTHLLEVEDELAKLRHEKTEFLELQNRNWCLEEAKITLEKQIFERNDQIKAQEKKINELQVKLNEGEQENVKTKDQEVSNQKAYDELKKTLEEKTKLLDEISKEKDQGNEALKQEIEKLKEKIEELIKESKKERDALVEKYEKDIEDKDNLIKTKSKELEEETVQNVEKQKALAQLRVDNEEQMNKLTEKLNEQLLSKDQQIEELKLKAHEEGSKLKIALEEVEELTKKLKAAEEMNQELKRQIESLQINSGNETKVIIEEKNKLEESLASLKATSTAYSAQLEKLNEDLKMKHAELVELQKSKDAEIKQLMDNFESKLEEKTRFITEVNADLAIKSSKIANLEHEIAELKRLLASKDEEINSLLEKASELKDAITLSEQTKTNLESELRMYEVNIAELNQKLAHSEEKISQLVEQKSKLEAEISSVISSSADSSEQLIKYNEDLRLKEKELDQLRERVFELENLSTSSEAKFNRAEEELKAANQVVEQLKAEIGEIRDQLDGQVKAREELSKELGVFKAKEAELSGIKEALVEEVKIKQLAIVNLSVQLKAAEENLSGLKDKFSALSCSNEEKSKEFKNYSEELEQKVKKLEEESRSLKESGEKLLGEKEVVEKTLGDLKQKLEEEIASKGRLESLSGERESQIKSLEVRIEELNKEKEEMSSVVQELDVKYNESLAQLKLANSKDADTSQEVTLMREKVEQLESSNGELKKSLEVMDQSATGLKKELSEAKARSQELEGKIKELESSAAECDKLRTELVGERELVVKAGEEKIRYLKDLEETMRDKRALEEKISAVENEREGLKREFEVKVRELESLQVEKQALGEKLKVELEASGKEVSLAKKRNQELESLVDTMKSEVSSRDSVVAELQKLIEEMKKDKDQLVSGEKTIVSELEKKQSEVVAIKAENESLLGEKVALEKELKDREGQIQALTNLVASNESDVVKRTQSIAEELSKVRKDSDALKENQNALEKENKTLSAKLSHTLEELKTAMENKKNSLEVKSVDVKNNGNKNGELIQLIEENETYKGQIDFLNSVIVDMQQKNEKLLSKVQVLEMGVPANEADDYSKYSLDKKAGTPRMFCDICDQFDLHETEDCPKQAQDFEVEKPVKKSKKSSFACRLDEDLLNFLEYIFVRGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2025-04-02" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HD14</accession>
    <name>A0A8J2HD14_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS5024</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5088912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="7695876at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="191"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="379"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="444"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="537"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="830"/>
            <end position="898"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1022"/>
            <end position="1069"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1901"/>
            <end position="1926"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2207"/>
            <end position="2257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2347"/>
            <end position="2366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="198"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="241"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="400"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="463"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="568"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="606"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="673"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="843"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="861"/>
            <end position="871"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="883"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1033"/>
            <end position="1047"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1048"/>
            <end position="1063"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="2211"/>
            <end position="2238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5088912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="2366" mass="264059" checksum="C3CD283AB62BD860" modified="2022-05-25" version="1">MFYQHNYDAVFYTGISSSKKETFENIKSDIIKNDNFFNNDNNESKVEINDDKNLLNCDDKKDIKTELSDTNPIEDEEKLQAVIVQYCTDVEWKKRFKKITFLPVVPYSHHDMPCSVDPRRIRQCMKACFSLLLKTLPKFDETIDCDNYYSFLKSPTKVIIKSVEEKFYWKDDILAENFLINDCAFSHDGGLVRSSDNKDDESDDAESIGSSEETEDRSESTEDSSSEQVSESSDEIDASEDTSRSENLDRSDNNLPESVENINDRVTVDECPELLDEAVGLTSHVPFQPKKSLIKLKSKRFNQISDEIVNVDDSSVINVPDVENIVESLNESPNSNLKITFKKLHDGTWHNNNNNNNNNNNNNISNLNETEIREENLAKFEPKEIMPSQKIPSTQESNGKRRISRIKSSRHNPEQVEIDAKLKRLKRKVKVDNNKTYIVKPKSSSTNFTKKRIQKTKDKETRTQSNDNQSLNPCRPLIIENHTPFHTDVIYSTPLKHDPVIRTKHFVRRSNKLEDHFGKPADENEKEENARLIAESEQAARVKYSRRSVDSGISVRDTSPVDLPTRDLEEDEDDGIEDFDNFNMKSYRGSSLERRGSSSPRQSLSHRCEQSDKKHYSSPRSNEKLSKDKRNKNSERYRSKDSSRSHKDCSRDRSSRDSSRSDRNCSRDSSVVSDRDRSRERSSRSDRDRSKDKSCRSDRDCSKDKSSRSESDRDRSKDKSSRSDKDRSKDNSSRSDKNRSKDRNSRSDRDLPRPSNSRSATEHSEKVIKLGRSLSGSELTSRSKKDSLLGCDSSNNMDDEIKYRIAKQLEGMARNEVNYFKKIQSRIRKRRNSLQSASKNSELHSSTSEECSSSKQRRTLSKNTSGCQSIDISPDSPEDVHISSPGLPSLSPLPQDMNTDVQIGSEEMVKDNSDVLSLPVIVSFEEPLIDVNTDQVSLPTCDNFSVGTNIININSNDLPESNIMDDIIDIISKDSEEDKLKSSNLFINQLELCSKLPSESPGQLEVLNPSVQTKSLVATVPSESSLNLPASSEEIKIEPESETHQPTDESNSNELTLNDSNRPVNIKKEPYDFPEDVECITIEDDLVAIREEPVEESQLIDNINSFNISSPSTSSGFIRAIRPTELGARSDCFTPAPAVIQDSLETFQVSQQNIPNTQKGTLGVSFQQSQYLRGSHNLPPQVSIPRRGRVNKRQTKSNVNCNTLANSSELCARLLCNANQFDHSSPSSSSSSSIPATTATISTVTAKTVTPPAIIPTSVSTQGSIQLTIEEILLLEQYLVGDIEAKLLSILKSIDTTIKCYEYLRNTLLDNASRQKGRRSFTQCVDAVFELMSQLDLKMKQPSERDSASKLLFAYSKKIESPINLNIMNTIKCWYSQVIDEIKLHDAQEPIQSESSATTCPSVPPRQQYQNQPLQLQNQQDYAVLKGALASPTVHSQPAKNLPPPQYPMKNAVYQITHPFDDSATNAPPNYIVGVNSITKQVRMAPNNSAAGATSSNLPSYQSAVAANTLKYPSSHYQAPVPINTARYPSAEVSSHSPSSGKLPVSSQNSALVHTQSNQVHPLIQNQVPGQSQSSQQVPAQYQSQMPNQALQLPQHPMVPLMQITNPNSVQNMARTQAAMYSVNHQVINNSNYQNITSEMSHQTYSSQNNQYFSLQHHNTHAKQPSAVNSQNINLFHQMTAAPAPSMSLSQNVQAIHANVNQYQVSQPSVTVSQSATAATATHTAVNQAPTFSNTNTNLTEQTSAVNLSKNSGNEVQVVTQVRTQATTYDRQVSVIQSQASDNQTTIRTQTSAVSNQVPVVNNQVPVVNNQVPVINNISIVDSQVNVNSQAPALFQSQTLTIQSQSTVIDNPPLAQNNILTNNVIINNETQVANNKPNSGEQIDRPVFIWCIALAQIDNSTAQNSPSNNNTASITEDSVKNTPLVNESNNLNKQAENSSLNANNLPEICEEMNVNDEESASNAVTKSSEDNLSLVNKIPDVPTAAVPTNSKEKSYERLPLKKRLNQDYNTQQCSPTKKSRDRVEVNKVIFNYGSEAMAIDSTENNSADKEDLIKSSEDICSSVLKDKSSKEEKVLDHQPVVLNIIPENELVLLSGSDEDTNNESREEMATNIDQIEKLVVDFIQNKEEMLLGNQEILDIEANKVDKGKNQQSDLLQQELDVENEVSSSTEINTVNKTSLEVTKKVDAETDVSTSFDDKSCKSKQIELVTLDSDEESDDEANIETEVEDNDEDDNGNDDSDNKSHSTVPATPLKTDPEEEIGEEMEVEQFKYTQSSIDEEIDCVAIANNSSVVEKPAEDNNKDDDVDNQESSIPLIMGVCSITEDAFETIDKSVAQVMMEDIVDVTDQEKNSVALDNGDSEDIIKLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HD25</accession>
    <name>A0A8J2HD25_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Mitogen-activated protein kinase kinase kinase 7</fullName>
            <ecNumber evidence="5">2.7.11.25</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="30" type="ORF">HICCMSTLAB_LOCUS6312</name>
    </gene>
    <organism evidence="30 31">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="30" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="25">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.25"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="24">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.25"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="30">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.25" evidence="5"/>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5092682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HD25"/>
    <dbReference type="OrthoDB" id="10261027at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004709">
        <property type="term" value="F:MAP kinase kinase kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071560">
        <property type="term" value="P:cellular response to transforming growth factor beta stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006955">
        <property type="term" value="P:immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007254">
        <property type="term" value="P:JNK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043123">
        <property type="term" value="P:positive regulation of canonical NF-kappaB signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043410">
        <property type="term" value="P:positive regulation of MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009893">
        <property type="term" value="P:positive regulation of metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd14058">
        <property type="entry name" value="STKc_TAK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000143">
        <property type="entry name" value="Mitogen-activated protein kinase kinase kinase 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000152">
        <property type="entry name" value="Mitogen-activated protein kinase kinase kinase 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46716">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46716:SF1">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="17 26" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="27" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="16" id="KW-0418">Kinase</keyword>
    <keyword evidence="18" id="KW-0460">Magnesium</keyword>
    <keyword evidence="22" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15 26" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="31" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="21" id="KW-0346">Stress response</keyword>
    <keyword evidence="23" id="KW-0804">Transcription</keyword>
    <keyword evidence="20" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="12" id="KW-0808">Transferase</keyword>
    <keyword evidence="19" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="Protein kinase" evidence="29">
        <location>
            <begin position="82"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="28">
        <location>
            <begin position="24"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="28">
        <location>
            <begin position="414"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="27">
        <location>
            <begin position="538"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="28">
        <location>
            <begin position="36"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="28">
        <location>
            <begin position="425"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="binding site" evidence="26">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00017660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00047559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00048329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="29">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="30">
        <source>
            <dbReference type="EMBL" id="CAG5092682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="31">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="615" mass="69939" checksum="BF9A9395217BB2A5" modified="2022-05-25" version="1">MSKNIKQENQQLDLIDFGDKKLDFNTSGPTKTKTVESTPLSSSSSSSSESSQLSTKSPSLPPKLLKQKLLQQFVEEIDYNEIETEEVVGKGSFGVVWKGKWRGRYVAIKHINTEGERRAFAVEVRQLSRVSHPNIVRLYGACTKDPVCLVMEYAEGGSLYNVLHCEPKPRYTASHAISWALQCAQGVAYLHNMKPKPLIHRDLKPPNLLLILGGRTLKICDFGTACDLNSYMTNNKGSAAWMAPEVFEGSRYTEKCDIFSWGVILWEILARRKPFDDIGGSAYRIMWAVHVGQRPPLIEGCPKPIEDLITRCWSKRPEERPSMDEIVRVMTCLASFVNGHLEPVEYSMSEDYEENYDDNDDEINQDTIDVSWDMSSSQINGYPVNGINNDKIDLLNQPQQLKTIQNSQEFRDSNVNHNFPQMKPSSNNNRDSNNRFQPLHVECDPNAWDLATGTDSSWELQNTAGFDRMGPKKHNRSNNNDNLDDICGLLEADLRPLTPDNTCQLSRTIFEEHKQLAQEYLKVQTEIALVSQYKSEMMKNLNSEGVRRQQELRKLEDEKEALIKLHDNLRRQVDMIKGIRRPTPLVNSSNTMNTIMAGEDGWVCVSSRQEPSRIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HDR3</accession>
    <name>A0A8J2HDR3_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Similar to tacc3: Transforming acidic coiled-coil-containing protein 3 (Xenopus laevis)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HICCMSTLAB_LOCUS8038</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TACC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5096095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HDR3"/>
    <dbReference type="OrthoDB" id="10255048at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007052">
        <property type="term" value="P:mitotic spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007097">
        <property type="term" value="P:nuclear migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1700">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039915">
        <property type="entry name" value="TACC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007707">
        <property type="entry name" value="TACC_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13924">
        <property type="entry name" value="TRANSFORMING ACIDIC COILED-COIL CONTAINING PROTEIN 1/2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13924:SF10">
        <property type="entry name" value="TRANSFORMING ACIDIC COILED-COIL PROTEIN, ISOFORM K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05010">
        <property type="entry name" value="TACC_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transforming acidic coiled-coil-containing protein C-terminal" evidence="9">
        <location>
            <begin position="711"/>
            <end position="904"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="27"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="604"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="688"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="840"/>
            <end position="892"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="27"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="619"/>
            <end position="628"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF05010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAG5096095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="912" mass="101435" checksum="714158721E36E60B" modified="2022-05-25" version="1">MSSPTKIQASPKGIREGTRVILREITATLNNSPPSKTQMSGNEASKKSTPEHEVKVKFAREFADAEIYPPAVCPTTIITPVESNSISTASSFQSLTSTLSTKSSSGICVDSPSRSNDNSYNNLNDTGLDDLISACARIRLEDSVINSGDQSFGDVTFASATDELQLDRTLDVTRSGTVSPVEGNATQTINTPVNDAQTVFPNSPSSCDLNSTWNTNTPTADTNVLEIVQNNATLNTSAEQISPEYSTAPDLHTNFSIKSPVNESNVEPSNCSHYLEAIESSVTNNSQVLISPPISSDDFNNSEFKKPLPIDDLKVSKHVLNANIVSLDSLESNKFIETPLEIPTDSTFKLNETISLEAPGDLENINSLAIETNLDKIITENISTIPVTDNISDHVELITKTPEIFVEGTKIPEIEISEANEVRSEPVCELESTLLVDGINFTSSSEDLQESLNREAELKEKQETDIPVCPVIEGLNLPNDYVNFTPQRQSTSLVSGIIQPDTKIEESFKNLDLPESKFFDVENAPPLDPPLDFDQLNLETENIIKDIHNSFTGLETEKFVPASPDQFCDPSQFDFLLAKTENCRGDRLRSDSLFTKFDPLVAETSMLPQGNGTSPPPSNDERNGEKDTSLPNNITPKRNPAIAAIDRLLFYSPMTPDNIKIQVSEKKESVEKTESPVPVVDSAMASELELVRSTVLQLEEQLEKQKQSYEKQSDEKDKKNKSLQEMVAQLQRQLTHEIQLKDEMTAIVDEHEKSISRLVAEREKSRNDLDTEKAFLLRELADTKKHLEASEASFNDVHAKYEKIKQTMTMYTNNEVTLRESLENNVEVMKGLQSRYEQIKLHAATRLEKANQDLEMMQKQHESEIIKLRAMLKKEELKCNSLTEMIDQKAKENKELTKILDDVIARVNPNDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HEF3</accession>
    <name>A0A8J2HEF3_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Similar to Tmem67: Meckelin (Rattus norvegicus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS8117</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5096253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HEF3"/>
    <dbReference type="OrthoDB" id="419138at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036038">
        <property type="term" value="C:MKS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019170">
        <property type="entry name" value="Meckelin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21274">
        <property type="entry name" value="MECKELIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21274:SF0">
        <property type="entry name" value="MECKELIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5096253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="306" mass="36014" checksum="4ACF81D1759F04CE" modified="2022-05-25" version="1" fragment="single">FFRSNWLLGYVPTLYDNKQTHTVHIFYCFLKHSLSYCQTMDEYLTCFFILLHSINYVMSDSDDFIFEYSNPQECSRNELFIPHNFTCQKCPSNLISSENRLECICEKNGRQITSEDDTVSCERCQYSTILTSDKTDCIYCQNNTCHCSSNQIKIERHHNGTLLDTLMCLPCPENSFLSSDNSKCLPCSIIFTKNYEKIFSSTILDERILKYCLQNNLTEWVNIKESYLIKYQRQVIDSYYLRTQLPVAHQSCRKKNNDACEHLSNICLLTLQFDSFPCKLIFDKNLTNSTRLFHPKKENNKILNRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HEM3</accession>
    <name>A0A8J2HEM3_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS6631</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5093160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HEM3"/>
    <dbReference type="OrthoDB" id="7696210at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46113:SF1">
        <property type="entry name" value="PEPTIDASE M17 LEUCYL AMINOPEPTIDASE N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46113">
        <property type="entry name" value="SNAC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5093160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="95" mass="11127" checksum="03B97235D94D82C1" modified="2022-05-25" version="1">MVKGSKFYLFIDLSHFVCKRSLVLFERFGLSTEFLDVDITLWASHRSFQENIQFFSSLKVVNDVAERNVALITKYNQHLTNSEEQFQGLLQTFDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HEM4</accession>
    <name>A0A8J2HEM4_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS8288</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5096595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HEM4"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5096595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="93" mass="9472" checksum="15004089E63F123F" modified="2022-05-25" version="1">MKAGSLKNLREGATVYKLANDFPNGGGGGHVEYGYPTGYVGTYGGPRGCVHGGAHGGAHGGAHGRLHGEFEGNIFPQPCDHYGPPCVAKAPNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HER1</accession>
    <name>A0A8J2HER1_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS8350</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5096718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HER1"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.120">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5096718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="260" mass="29167" checksum="84D33998E4558B76" modified="2022-05-25" version="1">MEFSSFQPPNMLKSTTVKTYGIPSTIPGVVVLQSSSFHQGDQKVFKHRLAGAQCTSISAVACCILSRKIEPVMREDLEKILIQGDQYYLQCKKIAIEADYLNVEDLLESFIVDDNLVILTYEDITYGRFCDSDLRSKLCECINVCCQRSKLSVSSGFLFTGQQKTVSFVVRPDNTFWLFNSHCVDVNNRFPIQEPSEGTARLFKCANPEALASREWGTTILQLIDLADNKDNKNRQGLTSLAKLIAEMNSQHNISSGVEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HES1</accession>
    <name>A0A8J2HES1_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to Lix1l: LIX1-like protein (Mus musculus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS8040</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LIX1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5096099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HES1"/>
    <dbReference type="OrthoDB" id="6250996at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097352">
        <property type="term" value="P:autophagosome maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051436">
        <property type="entry name" value="Autophagy-related_EPG5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029270">
        <property type="entry name" value="LIX1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31139">
        <property type="entry name" value="ECTOPIC P GRANULES PROTEIN 5 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31139:SF6">
        <property type="entry name" value="PROTEIN LIMB EXPRESSION 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14954">
        <property type="entry name" value="LIX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54768">
        <property type="entry name" value="dsRNA-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="152"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="157"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5096099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="299" mass="33293" checksum="52550858FA18B7F6" modified="2022-05-25" version="1">MQGIMPVKTKTRVPESMGVSGDLVDARAKQVLREAVDAVVNSFAKHTQGYGRVNVVEALQEFWQMKQSRGTELRNGALVIYESVPGASPPYVCYVTLPGGSCFGSFQSCPTKAEARRSAAKIALMNSVFNEHPSRKITDDFIEKAVAEARASFNKPAPTSNGQSQNNGDEKEDPNTGIGAFRFMLECNRGRTMLEFQELMTVFQLLHWNGSLKAMRERQCSRQEVVAHYSHRALDDDMRSQMALDWVAREHENGGGVVAMELALAERELETARLAGRELRFPKEKKDILMLAHAQVCPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HEX0</accession>
    <name>A0A8J2HEX0_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Similar to VPS39: Vam6/Vps39-like protein (Homo sapiens)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HICCMSTLAB_LOCUS8734</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Lysosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the VAM6/VPS39 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5097491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HEX0"/>
    <dbReference type="OrthoDB" id="5325112at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034058">
        <property type="term" value="P:endosomal vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000547">
        <property type="entry name" value="Clathrin_H-chain/VPS_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001180">
        <property type="entry name" value="CNH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032914">
        <property type="entry name" value="Vam6/VPS39/TRAP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019452">
        <property type="entry name" value="VPS39/TGF_beta_rcpt-assoc_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019453">
        <property type="entry name" value="VPS39/TGFA1_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12894">
        <property type="entry name" value="CNH DOMAIN CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12894:SF49">
        <property type="entry name" value="VAM6_VPS39-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00780">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10366">
        <property type="entry name" value="Vps39_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10367">
        <property type="entry name" value="zf-Vps39_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00036">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50236">
        <property type="entry name" value="CHCR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50219">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0458">Lysosome</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CNH" evidence="8">
        <location>
            <begin position="14"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="repeat" description="CHCR" evidence="6">
        <location>
            <begin position="574"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="426"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="429"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAG5097491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="880" mass="100700" checksum="19E140EB9501F35A" modified="2022-05-25" version="1">MHDAYEASPILKLTVQIESMAAYDDNLLIGTREGHLLIYNVPMKSNEYGKLELLRYSKNFSKKRIVQVDVVPEYSLLILLTDDIICVHDLNSVNIQQINQLSKTKGATLFALDVQRAGSLTGVRLCVAVKRKLQLYYWKANNNQFEDLGDEPRNEISLSDVPRELAWCGETLIVGFHGLSYTLINLDGKTKELFPTGKPPKPSITKLSNSSFALGKDSQSIIMNTTGDLIQHNPVKWTDSPTATVWDDPYLLGIVHDTLEVYTLEGSLHIQTLADFNKARLLCRCKQGRVYIASISQVWCVSSVDVELQIRKLLEQNQFQLALKLTSLSDTTEEEKAKRTYKIQTLYAHHLFCNKKFQEAMKQFQELGTDPYEVIRLFPHLVSQSSNTNDVNEPVAGLPKLQDRDLENGLLALIGFLTEVRHNLMGSTDSKDKDNKTEKNKDKDKKAMTAVATEQLLKIIDTTLLKCYLQTNDAFVAPLLRLNHCHLAEAEKTLLMHQKYPELIILYQTKGQHKKALELLEKQSKQNDSSLRGTERTIQYLQHLGKDHMDLILKFSGWVLEQDPEQGLRIFMEDIQEVEQLPRPKVLDYLLRCHKDLVITYLEYVVRVWEDENPLFHNVLVHQYKEKCLASMSLAATPAEKQSGEHVRQKLQQFLEKSTQYTAETVLIQFPSDCLYEERAIILGRLGRHHQAISIYVNLLNDVPRAIQYCKNVYARYESQKNIEGGKCQDGADEVYVTLIQQLLKPEPFFVSGSSEIQKTAQPDLETALELLEQYASKITPINALQVLPDNVPIGRIRHFLEASLHNQLSERRKTQVLKGLLQAEHLQVQEQRMHYESKSVLMTEFNICPVCKKRFGNQSAFARYPNGEIVHYSCQERKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HEY4</accession>
    <name>A0A8J2HEY4_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Retropepsins domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HICCMSTLAB_LOCUS6796</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5093406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HEY4"/>
    <dbReference type="OrthoDB" id="8057740at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00303">
        <property type="entry name" value="retropepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018061">
        <property type="entry name" value="Retropepsins"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00077">
        <property type="entry name" value="RVP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Retropepsins" evidence="3">
        <location>
            <begin position="84"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="31"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="226"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="38"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="60"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="226"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="262"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG5093406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="281" mass="31865" checksum="E00F3C31CADF8C09" modified="2022-05-25" version="1">MPPKGAHQRTMYKSGGKVLYAMRKTGRVFSRLLPLPGKRREDRHALPKPAREPTGSTNPSKEHYPDQSRVSAEHFRPIALKPGEKRPLAEIGLGGIKIHALMDTGATASIVSQRIWDFIRENRLQTKHNPTPIRGSTLGNQVILSSGTVWVNVQENNRSYELPFHVMPAYANDMLLGVDNLAILGYQLQRRAESFNALDMEYDLETARREIKTWLKLDEEIVDFKRFHEGNPPEPDHEKPEREQIDRENPEPDLDETLGPRRVTRAMAKKAKLASAAEEPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HF52</accession>
    <name>A0A8J2HF52_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Probable ATP-dependent RNA helicase DDX46</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">DEAD box protein 46</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">HICCMSTLAB_LOCUS6490</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="14">Component of the 17S U2 SnRNP complex of the spliceosome, a large ribonucleoprotein complex that removes introns from transcribed pre-mRNAs. The 17S U2 SnRNP complex (1) directly participates in early spliceosome assembly and (2) mediates recognition of the intron branch site during pre-mRNA splicing by promoting the selection of the pre-mRNA branch-site adenosine, the nucleophile for the first step of splicing. Within the 17S U2 SnRNP complex, DDX46 plays essential roles during assembly of pre-spliceosome and proofreading of the branch site.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus speckle</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the DEAD box helicase family. DDX46/PRP5 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5092971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HF52"/>
    <dbReference type="OrthoDB" id="196131at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd17953">
        <property type="entry name" value="DEADc_DDX46"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22473">
        <property type="entry name" value="KH-I_DDX46"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000079">
        <property type="entry name" value="probable ATP-dependent RNA helicase DDX17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000584">
        <property type="entry name" value="probable ATP-dependent RNA helicase DDX46"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056149">
        <property type="entry name" value="PRP5/DDX46/KHDC4_KH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23469">
        <property type="entry name" value="KH_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7 22" id="KW-0347">Helicase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="10" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="21">
        <location>
            <begin position="357"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="19">
        <location>
            <begin position="388"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="20">
        <location>
            <begin position="577"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="167"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="230"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="17">
        <location>
            <begin position="357"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="18">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="31"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="55"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="96"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="239"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00038511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00050029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00050042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="CAG5092971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="1019" mass="115081" checksum="D16E764A6A5164C6" modified="2022-05-25" version="1">MKDRHHRRRSRSRSRSRSVTPEKKRRRSRSRERDRDRDRERDKEKRYRDRRSRSRDRDRDRRDRDRDRKRGDSKEKRTDSSKSRSTKDRKRSRSKEKKDKEKNEEDLPFDHTRLDKEEEQKRLELEMQKRRERIERWRAERKKNELEATKKDGKPILANLQLPMKKWSLEDDSDEETVPVSTTGAKEGEEDDVKEEAVELNPVVSLDEEEIDPLDAYMAGVQEEVRKVNKVDPKAKSATNGNSTSNSSSGVVIVTGVAKKKVQKQKGELIEQNQDGLEYSSEEESENLHETAAGIANKQKRELAKVDHANTEYLPFRKSFYVEVPEIARMTNEEVELYKEELEGIRVKGKGSPKPIKSWAQCGVTKKELEVLKRLGYEKPTPIQCQAIPTIMSGRDLIGIAKTGSGKTLAFLLPMFRHILDQPPLADGDGPIALIMTPTRELCMQIGRDSKKFTKSLGLSHVCVYGGTGISEQIAELKRGAEIIVCTPGRMIDMLAANSGRVTNLKRVTYVVLDEADRMFDMGFEPQVMRIMENVQPGRQTVLFSATFPRQMEALARRILSKPVEVQVGGRSVVCKDVEQHVVVLEEDQKFYKLLEILGHYQDKGSIIVFVDKQENADTLLKDLMKASYSCMSLHGGIDQCDRDSTILDFKAGRTKLLIATSVAARGLDVKQLVLVINYDCPNHYEDYVHRCGRTGRAGNKGYAYTFITPEQEKYSGDIIRAYELAGVPIPEKLKVLWDRYRARLAADGKKVHTGGGFSGKGFKFDESEAALANEKKKFQKAALGLQDSDDEDIENDIDQQIEIMLAPKRSIKEITRPAAASLGLTGQPQPSATDKLELARKLASKINIAKNLGAEAKGATQQAAEAILKGAGPTNLITAKTVAEQLAAKLNTKLNYQPREEDLLEGDGEIGEQTFKKYEEELEINDFPQQARWRVTSKEALAQISEYSEAGLTVRGTYIVPGKSPPEGERKLYLAIESTSELAVSKAKAEVSRLIKEELIKLQSSGAHTASRGRYKVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HGR0</accession>
    <name>A0A8J2HGR0_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Genetic suppressor element-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS7190</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5093864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HGR0"/>
    <dbReference type="OrthoDB" id="5955164at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="231"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="360"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="231"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5093864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="504" mass="55369" checksum="07530B137B03D7F3" modified="2022-05-25" version="1">MLIKLTNINSFRKIMDLAETMKNIVAKGMQTEMGPPTGTGGAGGGGGSSGYPQGSPSGAGYITEKMYMLLQLYLQNKGWNPSIELLQCFTELKEASMLPSAAYLQMMASRVALDAHGRLILRENGKIILPYEHFANAVMLKHMNGPTGLHLGLEGTVRAVMESYTIGRECFGMEKEFIIEVVQNCPNPACRYYKNQMELTQKMGHMAPTYIQDSEAAASLLRSSFSHNSDFGMSNSQSNSSHMPVAGSSSSDLSELQQRNTTQMNLQQRPPSRPSLNIPHRPASSQERKQSLGKHHYETIMANNNAAAVAAAAMNDHKLTDFLRSNNIDSIEGLNSLGLGNLQGLSNANKDLLALHNGAWANDDKNSRPNSSNPDTGGGKIVRAFAEVMKNMSRMKACVRPAMCKPYGKQSEALQKTLVDTIQLVQSLRSFLPPPHFPVSSWKNEDKHRLDHTSSYLSTSLKAAGAREELYEAHHHYNLVLVCAKCVLVTRRVIESTLIVKINN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HH36</accession>
    <name>A0A8J2HH36_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NAD-dependent epimerase/dehydratase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS8125</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5096269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HH36"/>
    <dbReference type="OrthoDB" id="16464at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050177">
        <property type="entry name" value="Lipid_A_modif_metabolic_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43245">
        <property type="entry name" value="BIFUNCTIONAL POLYMYXIN RESISTANCE PROTEIN ARNA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43245:SF11">
        <property type="entry name" value="LD23561P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="1">
        <location>
            <begin position="12"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5096269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="372" mass="41754" checksum="01CA291B86ECC15F" modified="2022-05-25" version="1">MATPTNNRKPGVIILGGCGFIGRNLAAYLVEKELVSYIRIVDKVPPQTAWLNKKHQLIFENPIIEFKSANLINPVSCQNAFVADVPIDYVFNCAGETKSGQTDPVYREGIYKLSINCAQHAAKLGVKRFVEISTGNMSSSEKAPHKEDDPTDPWTFIAKHKLQVENDLKNIPGLKYTILRPAIVYGIADKSGLAPRLVVGAVYKHLGEMMKLLWGPSLHMNTVHIIDVARALWHVAIRDDTISQVYNVVDEDDSTQGSISAMVSELFNINHDYWGNTLSTLAKTDMSTVVEEVNDKHMGPWAEACNKDGIENSPLSPYIDQELLYNKHLYLYNGKLLKTGFNYNYPKVTKELLKEILDDYVTMKIFPHSLML</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HHD3</accession>
    <name>A0A8J2HHD3_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Similar to NRDE2: Nuclear exosome regulator NRDE2 (Homo sapiens)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HICCMSTLAB_LOCUS10108</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NRDE2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5101035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HHD3"/>
    <dbReference type="OrthoDB" id="297219at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902369">
        <property type="term" value="P:negative regulation of RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031048">
        <property type="term" value="P:regulatory ncRNA-mediated heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013633">
        <property type="entry name" value="NRDE-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13471:SF0">
        <property type="entry name" value="NUCLEAR EXOSOME REGULATOR NRDE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13471">
        <property type="entry name" value="TETRATRICOPEPTIDE-LIKE HELICAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08424">
        <property type="entry name" value="NRDE-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="73"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="86"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAG5101035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="985" mass="115211" checksum="7CCD93066BC5EA2C" modified="2022-05-25" version="1" fragment="single">TMSLFPAYGIYNPSSSLEFPEAKTINESSASWLTNSSFQPEIVSGPRIVILSSDSSDCEVIDQLPEKNHETISLDSDVEEVDSPKHKSHHKKHKKSKKHKKDKYKDRPAKYKSVVENLYYEDRGKSKCIYKVDTLCSRARPRYHRYDKALGFVLMKKEKTTSTRYFAKNLAKKEAKSKTKSDTVIQRHKIATEEESEEMKEKILKLEEEKKSKIKYFNQQLMEDPHNIDLWLEYINFDDRDNEFGSTYGQKETNSLKYSRKLAIVEKALEKNTGCSKLLKAKLFFLDELLPTDEYIDRVEQMISKDSGNIVLWQALITATRSSVSLCNVSRVLKLYSKCFESLHLWPRSNPKVYDERLLKMTYQSLIFLRHGGLWEQMWEALRLNMNLNLNVDKQHAYFKGSIDEKKLIEMEEVILTSQLPLNQLWLRVELLRENCHWTSVSREQLELVGDSNRFITPEDVTEFVHPLLSKNYNFKMGVYIFLALKVPLLPTRHNFMQELGLDESNWTFESYESLIPILYPCSGEMAGHQQRELLTKGLFNAGLTSGPQYLRYHPARDAYLDFVRDVFRMIAESFGSDHQRTSFYVWWLRFERMLLWMQKNDAVKSDKSVKKLKGILKDFLKQDENRNNLHFYREYALIEREMGRVSNSVNILETAIQTKGNNPESCTNQYERAALMSLYRTLLEVLLDVRMWDELKSNISQVIRVLCAMTGKTEGSLELTEQYLHNCYQDFVDNFESVDQVDQEFLPVFHCDAIVCYIYLLFITEHGHQEILNIFDNCLEISKNCPWIQERFYEDKISFLQLMVELKIDKFSVLKESLKQAFEDNPDNFYLLSVYAGIESELPHWSICLRSVSNHEQRLWPTIAGCLAGRARLYSTICLNDSTARTAALNRLVHFHNNIFRVPDIRCCPLVWRLYMLLLREEGLCEKKGETVYHESISSCPWARSVYIDAAGIAPQLLTQIQDIIREKDLRMHVTPEELNILRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HHY8</accession>
    <name>A0A8J2HHY8_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Similar to Znf569: Zinc finger protein 569 (Mus musculus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HICCMSTLAB_LOCUS5765</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5090840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HHY8"/>
    <dbReference type="OrthoDB" id="8117402at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000260">
        <property type="entry name" value="Spalt-like transcription factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000325">
        <property type="entry name" value="ZFP90 zinc finger protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000100">
        <property type="entry name" value="Zinc finger 45-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001465">
        <property type="entry name" value="Zinc finger protein 560"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24381:SF393">
        <property type="entry name" value="CHROMATIN-LINKED ADAPTOR FOR MSL PROTEINS, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24381">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13894">
        <property type="entry name" value="zf-C2H2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13912">
        <property type="entry name" value="zf-C2H2_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="15"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="15"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="150"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="178"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="321"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="349"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="396"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="434"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="463"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="493"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="521"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="548"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="579"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="607"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="635"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="672"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="1076"/>
            <end position="1099"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="704"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="797"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="863"/>
            <end position="884"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="710"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="728"/>
            <end position="740"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAG5090840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="1099" mass="124814" checksum="EE1E54E343B26AD3" modified="2022-05-25" version="1">MEVSEDLTLHWEEDVGNVIHEEVICDLEDNLTDQDGEVIGACEEVCVEETVQTIIDSNSSTHNLPSDTEILMVPQSNDIESIYIMPQEDQGHDYLNIQVTEEVITDNWDRSGPDDGVEIPETKVSHDNLLEYDDMEIPIEQDPYTNTRPYPCDFCSRRFRKKANLMNHMTTHQNDRPHSCNLCGARYVRKSDLMNHLKTHAYAPPREGSDDDLNDEDSLALEDDDDIIKGRRKKIQSSVPRKRKNNATVIAKHNISPDVLTKLDKFGRKSYDYVEEDLHFVDDITTRGANSKASSSRWTESLIVTDSQPPRWPISDPTKPYVCQYCGMGFAREKALASHSRFHAGDSPYECSNCSDMFWDPNALREHMRVKHGLPSSDIDYDINETYTNDERFGQFYCDVCAVAFDRIDLLKRHRKIHVKQETEEVEEESNQHHVCNVCGEWFEEALALLAHAELHASRSPSRRCLLCGAKCRDDAEVAEHLRQNHADDAPPNTCTLCGKTCKDKRSLLKHSWVHNVDKTFGCTKCGKSFHSKARLRRHMVSHRNKMVACDECGEEFPDGRALVSHRHSHNKELGGRTFPCRECGKTFGSRSSQQIHLRIHTGERPYGCRFCWKAFADGGTLRKHERIHTGEKPYGCAICPRAFNQRVVLREHVRAHHSGPDPKYHGSLTPFFCKVCNNLFGTSEEIVLHIVQHCDENTALRRQPQVGPRKYKRRRKLKSHESPLPALTSQSNENFNTLEFGSESDDNTKRKLGRKNKQNRSSVEEGYQNVLKSFESSLQNINSIVNNSKTLSSAKTRLTKKKLKKDEKKVGETQLQAQPGRPRMIHTQKTRVPVELGTDGAKKGQKTKTMVTRTPKVIPTEHKLGIFPGGERNRPRTKNVSYHSDGKVQATLATFPKPKDSSDDIAPPVQSINPENIKMEMIAAPNNITINYESNNGNLENVKSKQESLSKKKVVKGKPGRRAVKQVTIKQEPQDIEIHEEIGSKNNEEYASSTIYNEPEIDGSNMEVAFEANVIADEEEHEAILPDLDGVNHDENLTNNVKLSVKVESTTQHQHIMSNVSEDVPETIIPDTIEYTCEMCAAVFSSRNELLNHVPIHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HIS6</accession>
    <name>A0A8J2HIS6_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Similar to bin3: Bridging integrator 3 homolog (Xenopus laevis)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HICCMSTLAB_LOCUS6292</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5092660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HIS6"/>
    <dbReference type="OrthoDB" id="446293at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015629">
        <property type="term" value="C:actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051666">
        <property type="term" value="P:actin cortical patch localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097320">
        <property type="term" value="P:plasma membrane tubulation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004148">
        <property type="entry name" value="BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046982">
        <property type="entry name" value="BIN3/RVS161-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47174">
        <property type="entry name" value="BRIDGING INTEGRATOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47174:SF3">
        <property type="entry name" value="BRIDGING INTEGRATOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03114">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51021">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BAR" evidence="5">
        <location>
            <begin position="15"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="30"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="148"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAG5092660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="257" mass="30042" checksum="1187469EC737BD6F" modified="2022-05-25" version="1">MTWNPRKKNYLNLKPSLAPPLLSVTEDRDLNLAVQRLMHVEATIRKLTKETKRYLEAITNLDRADQRLTTNLSACELIHINDEFRHIVEEYLTITTQVGKTVQDVNLLSHKTFIEPLKKLRDEFALIAEALAKREEIVNTWRTAHNRLKKLQEKKDKTASHVVKLEREKRAEEAAAKELKSIHSRLLVELPWFLEKRLDYIKPSINALIMIQLDYYGNTMKLFNQLMPLGNYTSDDEDALVNEQFTRIKSLTIVKDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HJ42</accession>
    <name>A0A8J2HJ42_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="19">Similar to Rhodopsin (Camponotus atriceps)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">HICCMSTLAB_LOCUS8814</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 16">Membrane</location>
            <topology evidence="1 16">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="16">Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5097661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HJ42"/>
    <dbReference type="OrthoDB" id="9996086at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009881">
        <property type="term" value="F:photoreceptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007602">
        <property type="term" value="P:phototransduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007601">
        <property type="term" value="P:visual perception"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15079">
        <property type="entry name" value="7tmA_photoreceptors_insect"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000044">
        <property type="entry name" value="Opsin, ultraviolet-sensitive"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017920">
        <property type="entry name" value="COMM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050125">
        <property type="entry name" value="GPCR_opsins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001760">
        <property type="entry name" value="Opsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001735">
        <property type="entry name" value="Opsin_RH1/RH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027430">
        <property type="entry name" value="Retinal_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24240">
        <property type="entry name" value="OPSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07258">
        <property type="entry name" value="COMM_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00238">
        <property type="entry name" value="OPSIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00576">
        <property type="entry name" value="OPSINRH1RH2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51269">
        <property type="entry name" value="COMM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00238">
        <property type="entry name" value="OPSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 16" id="KW-0157">Chromophore</keyword>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9 16" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="2 16" id="KW-0600">Photoreceptor protein</keyword>
    <keyword evidence="12 16" id="KW-0675">Receptor</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 16" id="KW-0681">Retinal protein</keyword>
    <keyword evidence="4 16" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="14 16" id="KW-0807">Transducer</keyword>
    <keyword evidence="5 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="15" id="KW-0844">Vision</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="286"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="322"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="359"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="400"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="449"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="domain" description="COMM" evidence="18">
        <location>
            <begin position="124"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="17">
        <location>
            <begin position="301"/>
            <end position="563"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU004951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="CAG5097661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="601" mass="67677" checksum="7A98724B7050F8F0" modified="2022-05-25" version="1">MSQVILDEDNRKHLEFLSKQPPQVLQDFCKLTNDYFQKGHNYKLYINAAQKLEVEPDNIKQSIEGLINLLIESCKNKLTPDDFKELVISLGFIDDKEPLITNLYTSKKPELESSLSNIGFKLPEYHNMEWRFETQIASRSMLKQCDPFVTMDFALKNSDDSQKLQHIVLQSDATNLLHVAEELEAALLEGRSQQIPMENVTSTIESISTILPASSISTALTTTAASPLSGVALISHAALSMGPHAAKQWMRYSNQTVADKVPEEMLHLVDPHWYQYPPMHHIWHKALGIVMVVIGILGWTGNGCVVYIFLIMPSLRTPNNILVVNLAFSDFLMMIIMSPPMVVNCWFETWVLGPLMCDIYAMFGSLCGCVSIWTMVLITYDRYNVIVKGMSGTPLTIPRAIIQISVVWILALAWSLLPLFGWNRYVPEGNMTSCGTDYLTKDWFSRSYILVYSLFVYYTPLFTIIYCYWFIVSAVATHEKAMREQAKKMNVASLRSGDQDGPSAEAKLAKVALTTVSLWFMAWTPYLVINYAGVFEASFLSPLFTIWGSLFSKTNACYNPLVYAVSHPKYRAALHDRLPCLGIGAPPPPKSDDSTSTKTEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HJC1</accession>
    <name>A0A8J2HJC1_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Similar to gatad1: GATA zinc finger domain-containing protein 1 (Danio rerio)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HICCMSTLAB_LOCUS8964</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5097961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HJC1"/>
    <dbReference type="OrthoDB" id="9994231at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039050">
        <property type="entry name" value="GATAD1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13340">
        <property type="entry name" value="GATA ZINC FINGER DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13340:SF2">
        <property type="entry name" value="GATA ZINC FINGER DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="32"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="79"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAG5097961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="232" mass="25987" checksum="3F766A306507C839" modified="2022-05-25" version="1">MENNKEKCGGQESPLWHSTELGSLCNKCLEDERNASNSGKNDEEESGSKPSRKSTRITRWCKPEKKNESSLPPTIKTVPKGKGRRHIFKKTPTKAPSSVATPVTSNFVFYKGSYFQVGDVVSVQDIDDNGIYYAQIRGFLTDQYCEKSAALTWLLPTVTSPPPEEGFSPETYIMGPEEDLPRKLECMEFVMHAPSDYYKLKNTPYPPALTESATGGYIWTSLGNEATTFYKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HJJ4</accession>
    <name>A0A8J2HJJ4_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Similar to lhx3: LIM/homeobox protein Lhx3 (Danio rerio)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">HICCMSTLAB_LOCUS8660</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5097343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HJJ4"/>
    <dbReference type="OrthoDB" id="10068367at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030182">
        <property type="term" value="P:neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09368">
        <property type="entry name" value="LIM1_Lhx3_Lhx4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09376">
        <property type="entry name" value="LIM2_Lhx3_Lhx4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000006">
        <property type="entry name" value="LIM homeobox transcription factor 1-beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000219">
        <property type="entry name" value="LIM/homeobox protein Lhx3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000032">
        <property type="entry name" value="LIM/homeobox protein Lhx3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049594">
        <property type="entry name" value="Lhx3/4-like_LIM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050453">
        <property type="entry name" value="LIM_Homeobox_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24208">
        <property type="entry name" value="LIM/HOMEOBOX PROTEIN LHX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24208:SF128">
        <property type="entry name" value="LIM3, ISOFORM G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00478">
        <property type="entry name" value="LIM_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 9 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7 9 11" id="KW-0371">Homeobox</keyword>
    <keyword evidence="5 10" id="KW-0440">LIM domain</keyword>
    <keyword evidence="2 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 9 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="LIM zinc-binding" evidence="13">
        <location>
            <begin position="76"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="LIM zinc-binding" evidence="13">
        <location>
            <begin position="136"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="Homeobox" evidence="14">
        <location>
            <begin position="215"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="9">
        <location>
            <begin position="217"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="23"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="288"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="338"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="396"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="40"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="339"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="12">
        <location>
            <begin position="349"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="12">
        <location>
            <begin position="416"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="446"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CAG5097343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="455" mass="49645" checksum="DE1FDFCA33F5F0F6" modified="2022-05-25" version="1">MIGLDMLGCEMFSLDSRMYRGRGDVLTPPQSSPESHHSHINNNNSNNLANSKDLQFDGERITLPKNIPDILLSSIPKCGGCQEAILDKIILRVLERCWHAKCLTCRECGARLTNSCFERNGVVFCKDDFYKRYGTKCAGCNEGLAPSQVVRRASNFVYHLTCFSCAFCSRQLDTGDEYYLMEDRKIVCKPDYEQAKAKETEFTELADGGSIDGDQPNKRPRTTITAKQLETLKLAYNNSPKPARHVREQLSQDTGLDMRVVQVWFQNRRAKEKRLKKDSNRSRWSHFFRNNTGSFKGSGGHSPRHDKLLDKDELKVDLDSSFGHHDLSNDSYSTVVNMGLDGDGSSPSAGGGNGGGGPPRGYLGATTPPYLTTSRSPSLPPHFPYPSDAGLSVYTNLGGPGGMVPGPASDLSNESSGGGGGGGGGGGGYPDFPPSPDSWLGEAPQHPHHHPHYAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HKK9</accession>
    <name>A0A8J2HKK9_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Similar to RPAP1: RNA polymerase II-associated protein 1 (Homo sapiens)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HICCMSTLAB_LOCUS10871</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RPAP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5102150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HKK9"/>
    <dbReference type="OrthoDB" id="348201at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039913">
        <property type="entry name" value="RPAP1/Rba50"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013929">
        <property type="entry name" value="RPAP1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013930">
        <property type="entry name" value="RPAP1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057989">
        <property type="entry name" value="TPR_RPAP1/MINIYO-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21483">
        <property type="entry name" value="RNA POLYMERASE II-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21483:SF18">
        <property type="entry name" value="RNA POLYMERASE II-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08620">
        <property type="entry name" value="RPAP1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08621">
        <property type="entry name" value="RPAP1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25766">
        <property type="entry name" value="TPR_RPAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="RPAP1 N-terminal" evidence="7">
        <location>
            <begin position="206"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="RPAP1 C-terminal" evidence="6">
        <location>
            <begin position="331"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="domain" description="RPAP1/MINIYO-like TPR repeats" evidence="8">
        <location>
            <begin position="949"/>
            <end position="1157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="78"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="81"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08620"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF25766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAG5102150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="1189" mass="133954" checksum="BC59F805352EE019" modified="2022-05-25" version="1">MDDFTPVKRPKPGDGEEELFRMQEEFVKSRQKPSAKVINLRAQHKEAIVKSTNEDNKQSDTKFRSKFAEMRALKTVEKAAQLQSNENISSEHSSKDVPNASTSKLLDPIRHVPLDAYKPLLGNIVEKKCKSSDQKSLKHMDNFENKTGFPSVFKIDHKTSAGSSNSLFYQTSLINKELNEVVASSSDDKIIDINPSDSIQDSVRSEIHKSNVEKLNSMTKEEILEEKKRLESTLDPKLLEFLRARKKPASSEYKIKVVEPKTMKPDSKEDVNKMECEPIPQEPPAPVTEMVEQASDKGWVHMDKVESEKLEWMKEIEPSKDGESTPDEPYNARFDFNGLLLPFKDDELLNKGLHNHGDEPDRPGYTLQELLQLSRSSTQQQRCTALTTLGNIMEKSRKGWYDKALNPPPLGALSQRNIILLLRFSLDDKSVAVITATLQALRAFLCSEADEVCMDRLCGWEYPDGNCLVPELPAPKHDVEDISTLKDHQLAQLDSIAAIMRSDIILRIRYILSELQPPPIGVTSALEILIRLARHSRITALNIATTPQLLDTIVKNFIPLTTERLVNFDTEKAYGVPNVTAIRLCRILVEYGGRPVADRLNNLKIIHSFLSYSNSNAGETGLRLAIEALRLWRLICSNNVATDSISGAKLILGSQLQLLLSNHDLTSASELSCEYATALVALSSREGTLRPTISTLLTKWSTQLAKVSSATWSTTKLVAVTLTSLNDLSPLKTEWTNNSKIFSNICSSSNLLSTCVPASERDPSSLPSLGVLTQDGEVQPAVSLNCCFPFLATLCDAMIKSSKFHDFEKIIQNPDVIKYFRQLVNYHWSLEFSWYSRAELFFITTIVRACAKFPTSDLINEIIWKIAVKLISTLPADASRAVNEVLGIVLSNERLAIDRLAEDLNAMKLNSGGENITLKLPNNISDIYKQYITSKNCWNEAAMPQDWPYMPLVDAYSNHKNKIGWNENDTIKITVVLSLELAMREVFYSLAPTVRFSRLVLVYLCDTVYLNDNVSFLLKRATFELISKYYKRFNFSSDLPGVGSFNDVFTSICECFIANSYGDEGFAVCLLVPIAQRHDAHYRKLLWSEHAGALRYLKLSPEKLACPVEEYLYPLEQDISLIESYLTALVRKTIKKEWCPLMYMIAIHHSAMFLRDTSPFAGKMRSRISKISDHELAECLLNYSPPVNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HKP5</accession>
    <name>A0A8J2HKP5_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">DNA (cytosine-5)-methyltransferase</fullName>
            <ecNumber evidence="15">2.1.1.37</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="25" type="ORF">HICCMSTLAB_LOCUS7627</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="25" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15 20">
            <text>a 2'-deoxycytidine in DNA + S-adenosyl-L-methionine = a 5-methyl-2'-deoxycytidine in DNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13681"/>
            <dbReference type="Rhea" id="RHEA-COMP:11369"/>
            <dbReference type="Rhea" id="RHEA-COMP:11370"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:85452"/>
            <dbReference type="ChEBI" id="CHEBI:85454"/>
            <dbReference type="EC" id="2.1.1.37"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 15">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="15 18 19">Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="25">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.37" evidence="15"/>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5095274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5376140at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003886">
        <property type="term" value="F:DNA (cytosine-5-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006346">
        <property type="term" value="P:DNA methylation-dependent constitutive heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044027">
        <property type="term" value="P:negative regulation of gene expression via chromosomal CpG island methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.120.10:FF:000001">
        <property type="entry name" value="DNA (cytosine-5)-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.490">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.120.10">
        <property type="entry name" value="DNA Methylase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001025">
        <property type="entry name" value="BAH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043151">
        <property type="entry name" value="BAH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050390">
        <property type="entry name" value="C5-Methyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018117">
        <property type="entry name" value="C5_DNA_meth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001525">
        <property type="entry name" value="C5_MeTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031303">
        <property type="entry name" value="C5_meth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022702">
        <property type="entry name" value="Cytosine_MeTrfase1_RFD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002809">
        <property type="entry name" value="EMC3/TMCO1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002857">
        <property type="entry name" value="Znf_CXXC"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00675">
        <property type="entry name" value="dcm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10629">
        <property type="entry name" value="CYTOSINE-SPECIFIC METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10629:SF52">
        <property type="entry name" value="DNA (CYTOSINE-5)-METHYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01426">
        <property type="entry name" value="BAH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00145">
        <property type="entry name" value="DNA_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12047">
        <property type="entry name" value="DNMT1-RFD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01956">
        <property type="entry name" value="EMC3_TMCO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037404">
        <property type="entry name" value="DNMT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00105">
        <property type="entry name" value="C5METTRFRASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00439">
        <property type="entry name" value="BAH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01415">
        <property type="entry name" value="DUF106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51038">
        <property type="entry name" value="BAH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00094">
        <property type="entry name" value="C5_MTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00095">
        <property type="entry name" value="C5_MTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51679">
        <property type="entry name" value="SAM_MT_C5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51058">
        <property type="entry name" value="ZF_CXXC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 15" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="13 22" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 15 18" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="14 15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 15 18" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 15 18" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 22" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 22" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <keyword evidence="9 17" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="1209"/>
            <end position="1230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="1288"/>
            <end position="1306"/>
        </location>
    </feature>
    <feature type="domain" description="CXXC-type" evidence="24">
        <location>
            <begin position="284"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="domain" description="BAH" evidence="23">
        <location>
            <begin position="393"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="domain" description="BAH" evidence="23">
        <location>
            <begin position="606"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="1249"/>
            <end position="1268"/>
        </location>
    </feature>
    <feature type="active site" evidence="16 18">
        <location>
            <position position="828"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRNR" id="PIRNR037404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR037404-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU000416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="RuleBase" id="RU000417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS51038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS51058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="CAG5095274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="1383" mass="156716" checksum="7309F43085DB4AC9" modified="2022-05-25" version="1">MSAQIKKNSRKRNLDESPHVNNSKRRKVNKENKSSNELTVNNNTTGNKTKRCEICNQQLNKLKLLAPLPENAVDEVVALADTKLSLESDIDSESIPGIWTQKIGPINEWYTSGYDGGPNQPILISTPYAEYYLMSPAESYKSFMDPVIEKIYLTKVVIEFLASRDDDPTYEDLLDHLQTVKLPDGLVLAEESLLKNAQFVCDQVTSFDVSATEEESDFPLLTTSCMRSIIKLTGATVGNDIKQPKNNEISPVKKKTMPKMILTKLVYQIVNKFFSKETDSKELFTTRQLMNCGTCNECLKPGCGRCAACKKNKSSKKKNSVCIKRKCPNKAIEAADSDTESLSDKNKSLKKIESIPEILKKMKVFSRKVKWISSSISSKNNRCYYSKAQVNSTTITVNDFVKIKSNNPRFELIVKIVTMWEENNDQKAHVNCFYNSRDTVLGNIGDSRELFASNQCADIFLKCLDSLVKVIRRNVPMKWSELGDTEQSVKEIKKNSNEYYYQMHYTPETARFEYLDSDLSVKSQDSCPVCLNKSQIQEAEKPQLGEPIVQDSRTSYGVLLYKSEEYRARTGVYINPGVVKFKYKFSVPVPEKLKQVDEELYPEYYRKYATGDHVKGSNYDTPDPFAIGCIKTIFTTSNDNPGLEDIFLVVNKIYRCENTHKSFLIPSADINQLFWSDEEIKIPLSEVMGKCKILLKPENDFNVGNHQFYVSSTYNAEEESFEVLSEDIKNSLENLSVNKEKKVKPLKTLDIFSGCGGLSQGLSDAGVADVRWAIEKDQAAARAFVKNHSNVKMYEGYCNVLLDSIMRKEKASFPQKGDIELLCGGPPCQGFSGLNRFNASQYSNLKNALLFTFLSYCDYYRPKYIVMENVKNFVFHHKGLMLKLAMYCFLQIGYQCTFAILQAGNFGVPQSRRRIILLAAAPGKKLPAYPEPLHVFSKRAWQLDVVIDGKKYSGNFSWKESAPYRTICVRDAIEDLPSISNGENREQIKHQKDPTSHFQKKMRKNEAFISDHVCKKMSLLVEARISKIPSTAGADWRDLPNIVVELADGTSTKKLEYRYEDSTGKLRGVCACAAGKTCDLKDRQENTLIPWCLPHTGHRHSGWAGTYGRLDWNGFFGTTITNPEPLGKQGRVLHPKENRVVSVRECARSQGFKDNYIFHGSVIDKYRQIGNAVPPLLAQAIGLEIKKITLAINLGVSSFLKLKMWADTVLIVFISVCTALLGEGLTWLMVYRTEKYQKLKTEVEKQMEKRKEAHGDSLDKQQKKKIEREEERLKNNNRDLSLVKMKSMFAIGFAFTALLSMFNSIFDGKVVAKLPFVPITWIQGLSHRNLPGDDFTECSFIFLYILCTMSIRQNIQKLLGFAPSRTASKQSGSIFGPPPQQFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HLE2</accession>
    <name>A0A8J2HLE2_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Elongation of very long chain fatty acids protein</fullName>
            <ecNumber evidence="10">2.3.1.199</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Very-long-chain 3-oxoacyl-CoA synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HICCMSTLAB_LOCUS10969</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a very-long-chain acyl-CoA + malonyl-CoA + H(+) = a very-long-chain 3-oxoacyl-CoA + CO2 + CoA</text>
            <dbReference type="Rhea" id="RHEA:32727"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:90725"/>
            <dbReference type="ChEBI" id="CHEBI:90736"/>
            <dbReference type="EC" id="2.3.1.199"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the ELO family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.199" evidence="10"/>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5102346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HLE2"/>
    <dbReference type="OrthoDB" id="434092at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009922">
        <property type="term" value="F:fatty acid elongase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034625">
        <property type="term" value="P:fatty acid elongation, monounsaturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034626">
        <property type="term" value="P:fatty acid elongation, polyunsaturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019367">
        <property type="term" value="P:fatty acid elongation, saturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030148">
        <property type="term" value="P:sphingolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042761">
        <property type="term" value="P:very long-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030457">
        <property type="entry name" value="ELO_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002076">
        <property type="entry name" value="ELO_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11157:SF103">
        <property type="entry name" value="ELONGATION OF VERY LONG CHAIN FATTY ACIDS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11157">
        <property type="entry name" value="FATTY ACID ACYL TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01151">
        <property type="entry name" value="ELO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01188">
        <property type="entry name" value="ELO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="5 10" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2 10" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="7 10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="27"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="67"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="118"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="149"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="172"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="207"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="236"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAG5102346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="266" mass="31282" checksum="E8F263AEAAF7E51E" modified="2022-05-25" version="1">MASFMKMVVSNYHEILESNKDPLVDTWFLMGSPVPVLAILSTYLLFVLKVGPKMMESRPPFQLNNVLILYNAIQVLFSIWLVSLVLNDKFISFIYPSSCSKDDVAPEKNVQEMISSAAWWYFFAKIIELLDTIFFVLRKKQNQVTFLHVYHHTITALFSWCYLKLLPGEQGLLIGFLNSSVHIVMYTYYMIAALGPRYRKWLWWKKYMTWMQLIQFGLMLVYLVAILAMDCAMPKALTYFFVTNVVIFIYLFSDFYRKSYVKKKTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HLX9</accession>
    <name>A0A8J2HLX9_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similar to CycG: Cyclin G (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS11539</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5103497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HLX9"/>
    <dbReference type="OrthoDB" id="769138at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039361">
        <property type="entry name" value="Cyclin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10177">
        <property type="entry name" value="CYCLINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin N-terminal" evidence="1">
        <location>
            <begin position="47"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5103497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="348" mass="39262" checksum="9B9ECD7DB3FD0A22" modified="2022-05-25" version="1">MDTTGSPAPVTIHSLLEQLQEALVLEVKYQPNLQLPAITKNDEVIIAERNGSAHVLRCLKVWYDLPSDVFFIAMNLMDRFLTKMKAQPKHMPCIRVSSFYIAAVQMSQTIDMDHLVSISQFKFTRGDLKRMSDLISNKLEWAPGTTPITALTFLRLFHVMFHAAASQLGLGELYASIVKESELVLRLEMVACNVECANLRPSEVALVLLCTYLDSAVNRLKSNTEATMLPVAGPSSAPVDFSQTPAHQILRLVEFATELQKICRISEASFASTLERVGAIMSKYNAQEQIPYRQRFVWRLSSRTARLLRPTDKFISNLPAIAENAPIPSPSRIRSGYRLNRRHDMKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HM11</accession>
    <name>A0A8J2HM11_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Similar to BIRC6: Baculoviral IAP repeat-containing protein 6 (Homo sapiens)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HICCMSTLAB_LOCUS13102</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5108167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="47801at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004869">
        <property type="term" value="F:cysteine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043066">
        <property type="term" value="P:negative regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032465">
        <property type="term" value="P:regulation of cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00022">
        <property type="entry name" value="BIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd23810">
        <property type="entry name" value="UBCc_BIRC6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000014">
        <property type="entry name" value="Baculoviral IAP repeat-containing protein 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1170.10">
        <property type="entry name" value="Inhibitor Of Apoptosis Protein (2mihbC-IAP-1), Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001370">
        <property type="entry name" value="BIR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022103">
        <property type="entry name" value="BIRC6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46116">
        <property type="entry name" value="(E3-INDEPENDENT) E2 UBIQUITIN-CONJUGATING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46116:SF39">
        <property type="entry name" value="BACULOVIRAL IAP REPEAT-CONTAINING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00653">
        <property type="entry name" value="BIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12356">
        <property type="entry name" value="BIRC6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00238">
        <property type="entry name" value="BIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57924">
        <property type="entry name" value="Inhibitor of apoptosis (IAP) repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50143">
        <property type="entry name" value="BIR_REPEAT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="4">
        <location>
            <begin position="4439"/>
            <end position="4606"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="2340"/>
            <end position="2410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="2867"/>
            <end position="2890"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="3855"/>
            <end position="3904"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="4681"/>
            <end position="4713"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="2340"/>
            <end position="2356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="2374"/>
            <end position="2385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="3856"/>
            <end position="3865"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="3883"/>
            <end position="3903"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAG5108167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="4748" mass="526994" checksum="486E433FADA1AB5B" modified="2022-05-25" version="1">[encoded data, 4748 characters]</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HMG3</accession>
    <name>A0A8J2HMG3_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transcription initiation factor TFIID subunit 6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HICCMSTLAB_LOCUS13390</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TAF6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5108744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HMG3"/>
    <dbReference type="OrthoDB" id="6621890at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046695">
        <property type="term" value="C:SLIK (SAGA-like) complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051123">
        <property type="term" value="P:RNA polymerase II preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22932">
        <property type="entry name" value="HFD_TAF6L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037796">
        <property type="entry name" value="TAF6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004823">
        <property type="entry name" value="TAF_TATA-bd_Histone-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10221">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10221:SF9">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02969">
        <property type="entry name" value="TAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00803">
        <property type="entry name" value="TAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="TATA box binding protein associated factor (TAF) histone-like fold" evidence="8">
        <location>
            <begin position="48"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00040091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAG5108744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="368" mass="41088" checksum="56B470251A8BADB7" modified="2022-05-25" version="1">MKELVQQTNLSSSINHHYGSKNNNSTSTTSTSNNSTNITNGNNQRRYAVLSNEWVSAIGEELGMHPLPDSLLKKLAEDASYRLREILHKCVTRLSHSCRKKLLSTDVNAVITTLCDADPVYGSSDPMPSYHSEAQVFVPHEELVDVASVALEPLNLTQINEPHCDEDEFIDAKLTEWPATADKFLPMLENVLSQDHKPSSNTINKKRITAMELLVGIQPLVFFQSTSSLSLDNLLKEAPEGSSLWHQIALSVNALVRSNQKLPNLKLLTENYGDSLLPYLEPIDNEQSNENLPRILPIIVRSKIRFAFAGGRPVAPNNLRRVSLRANYQILRGDNRATTASVACRRLLILKDKQNKLKNTYNLAAIQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HMP4</accession>
    <name>A0A8J2HMP4_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="23">Similar to Slc8a3: Sodium/calcium exchanger 3 (Mus musculus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">HICCMSTLAB_LOCUS12128</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>Ca(2+)(in) + 3 Na(+)(out) = Ca(2+)(out) + 3 Na(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:69955"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. SLC8 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="23">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5106173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HMP4"/>
    <dbReference type="OrthoDB" id="418484at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098794">
        <property type="term" value="C:postsynapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042383">
        <property type="term" value="C:sarcolemma"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005432">
        <property type="term" value="F:calcium:sodium antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098703">
        <property type="term" value="P:calcium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007154">
        <property type="term" value="P:cell communication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1420.30:FF:000001">
        <property type="entry name" value="sodium/calcium exchanger 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2030">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1420.30">
        <property type="entry name" value="NCX, central ion-binding region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051171">
        <property type="entry name" value="CaCA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038081">
        <property type="entry name" value="CalX-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003644">
        <property type="entry name" value="Calx_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004836">
        <property type="entry name" value="Na_Ca_Ex"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032452">
        <property type="entry name" value="Na_Ca_Ex_C-exten"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004837">
        <property type="entry name" value="NaCa_Exmemb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044880">
        <property type="entry name" value="NCX_ion-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00845">
        <property type="entry name" value="caca"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11878:SF65">
        <property type="entry name" value="NA_CA-EXCHANGE PROTEIN, ISOFORM G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11878">
        <property type="entry name" value="SODIUM/CALCIUM EXCHANGER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03160">
        <property type="entry name" value="Calx-beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01699">
        <property type="entry name" value="Na_Ca_ex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16494">
        <property type="entry name" value="Na_Ca_ex_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00237">
        <property type="entry name" value="Calx_beta"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141072">
        <property type="entry name" value="CalX-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0050">Antiport</keyword>
    <keyword evidence="11" id="KW-0106">Calcium</keyword>
    <keyword evidence="6" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="12" id="KW-0112">Calmodulin-binding</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="20" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="17" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="15" id="KW-0406">Ion transport</keyword>
    <keyword evidence="16 21" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="14" id="KW-0915">Sodium</keyword>
    <keyword evidence="18" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="7 21" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 21" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="28"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="91"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="124"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="157"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="190"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="Calx-beta" evidence="22">
        <location>
            <begin position="351"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="domain" description="Calx-beta" evidence="22">
        <location>
            <begin position="465"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="20">
        <location>
            <begin position="332"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00033667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="SMART" id="SM00237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="CAG5106173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="541" mass="60323" checksum="EBF733E500D6CF28" modified="2022-05-25" version="1">MSLYSLNCTEGLVIPMWYPQEDIGLSDIIIRGTVYFLLLLYLFIGVSIISDRFMAAIEVITSQEKELVVRRPDQEPQIVVVRVWNETVANLTLMALGSSAPEILLSIIEIWAKDFQAGELGPGTIVGSAAYNLFVIIALCVFVIPKGEHRKIKHLRVFFVTATWSIFAYVWLYLILAVSSPGVLEVWEGLLTFLFFPATVLTAYVADQRLLIYKYLHKGFRMNQRGVIVQGEASDSEAGVELEIKDHDGPHLFVDRVGDSCGQEAREFESTRKDYINTLRELRKKHPALPLEQLEVMAHEEVLGKGPKSRAFYRVLATRKMVGAGNLSRKISERAQSDLSEVKAELQRAEAECVNIDDINKMRIFFEPAHYTVMENVGTFDITVTRVGGDLDQACTVDYFTEDGSAEAGADYVEVKGTLRFEPGEIRKTIQLSVIDDDVFEEDECFYVKLANVSAPADLASPSLATVMILDDDHSGIFGFPEGGVIELVESVGQYPLKVVRYSGARGRVAVPYKTSEGTAKPGKQYVHCEGSVIFEDNQTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HMQ2</accession>
    <name>A0A8J2HMQ2_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS11157</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5102734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HMQ2"/>
    <dbReference type="OrthoDB" id="7685400at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5102734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="72" mass="8317" checksum="0B0F0F190F9B5F77" modified="2022-05-25" version="1">MEIKKVNTKYGPKILGILENEFSIFFPNRTNRMLIDNEEQLTSLIDLASAGELHLNYLGTAYHKFEFLIKPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HMR5</accession>
    <name>A0A8J2HMR5_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS13571</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5108935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HMR5"/>
    <dbReference type="OrthoDB" id="413313at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16021">
        <property type="entry name" value="ALP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.720.10:FF:000017">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004245">
        <property type="entry name" value="DUF229"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10974:SF9">
        <property type="entry name" value="DUF229 DOMAIN CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10974">
        <property type="entry name" value="FI08016P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02995">
        <property type="entry name" value="DUF229"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="182"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5108935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="823" mass="95886" checksum="6C1A35C4BE17B803" modified="2022-05-25" version="1">MESSKMFNILRVVFNYYKKNFKSISLLVLCFYLVFFVYFKLFIINSDFDAEFDSVSNDRVFERVEVEVKSNNFREKGIFGKFYGVKVSNSSIEKVEEKDGYEGVGSEDISKSDDNEVKNIFKKEERNKIKFSDFVKEKILKKKKEGENKSEFNDFEDQNIIQKKEEDKIFKKEKQRENKSEFDNFEDQNIIQKKEEEEEEEEEKIDENKYIVSNSKCRLLDQNPWDESIKKYIEPREFESCASTNPLLSSISRGIDGNFSIVINEEIAYEHYNNLINCCWSSIAQIKEKKPTVNNNIEFNVSECQDFKDQVQIPVGVELVKVVCRSFENLNKKIFTPDYQNIHVVLNSTKFKSRFKDDNLNDKNENKKISVLMLGIESLSRSNFIRSFPKTEKFIRNTGWTSLEGYNKIGESSYSNIMAVLSGLNGSSSSIYYKSEGQPYLDDFPFIWKDFKQAGYVTAFGEDVGNSNTFNFEQTGFVDPSTDYYPRSYIVATEKFLKQKNKKNNKYCSGPELSFERILNYALDFAVTFLNKPYFGFFWSNSVTHNDINAASSLDSHLLEKLESLEQHGVFNNTLVILFSDQGMHWGEIRNTSVGWYEERLPFVYLRVPETFKNSNNNYKYNTRDIIQALKMNERRLTSPYDLHETLRDILECAGGKSSYRSDCSTCQSLFKFVPDERGCEDVGVSPHWCACSEFTPHSSESKIAIKGAQNFLSYVEEIVKDYEDEDGRLCAKLELKKINRFDEIRLKNNNTGIRKFFYQIQVTPGNAVYEFTIDLDENKNFQVSEHEISRINSYKHVADCISVISHKKYCYCSNLLQSSNVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HN59</accession>
    <name>A0A8J2HN59_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Similar to TIGD2: Tigger transposable element-derived protein 2 (Homo sapiens)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HICCMSTLAB_LOCUS10779</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5101966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HN59"/>
    <dbReference type="OrthoDB" id="7581030at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050863">
        <property type="entry name" value="CenT-Element_Derived"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004875">
        <property type="entry name" value="DDE_SF_endonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006600">
        <property type="entry name" value="HTH_CenpB_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010921">
        <property type="entry name" value="Trp_repressor/repl_initiator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303:SF73">
        <property type="entry name" value="PROTEIN PDC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303">
        <property type="entry name" value="TRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03184">
        <property type="entry name" value="DDE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03221">
        <property type="entry name" value="HTH_Tnp_Tc5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00674">
        <property type="entry name" value="CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48295">
        <property type="entry name" value="TrpR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51253">
        <property type="entry name" value="HTH_CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH CENPB-type" evidence="3">
        <location>
            <begin position="102"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG5101966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="673" mass="77654" checksum="97825529D1CDB89C" modified="2022-05-25" version="1">MLKQKLEFIRTTKAIKFPIKKYNTTIPNKKILGKDNKPQQRRFSVAEKLEILKELDTGTITMTELADRNGVSRAAIYKIKQNRENLSKYANNISNRAIVNKKRTKSGYPLSEILDEILFAWLCQNRQLGLPLSGPYICEMALEVNRIIGGTDHFKASQGWLSSFKNRHGMKRSKVLGEKLSIDIDRYAEYQEDYIKIDKNQDYKIENIYIGDEGSLNWKSLPEESSKNSVTKDKVTILFCANANGSFRLPPLIIGPSTKPGSVRRKKPYPVTYAAQKSSQMEQKIFTDWYKNHFIPFVKNKQQTKDPVLLIIDNCPIHPPVEELNEIDPQFRVVKAYSKVTPVTDLLHRHVIQKTKIMYRKKLLQEIASSYEKSNDPDVFLNNFEIIDACYMMASTWQELSKKDLAATWSKLKKSYELAKKSNAKSFQEAASETFEYDNTAEFIKLLKNIPACEKCNHEDVRSWLKDDFFDQGWEPLKLKSIAQQVLDAHNMIIFDETCEDTELIDDKFKDEYDSDKKIPEDSDDSVDYTDFASLDDTIDVTKLEFLKSTESNNLKSEILQRKSTPESDGMDCSNLEIQELETDSNMIDVLEFPIPEPMSDSDVTDISKPENQKLKPDSLITPLDEDTLKAVDTIRRWYKLNANCKETIVRNHLEALQNMENYITTHIVSNYC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HNC7</accession>
    <name>A0A8J2HNC7_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Similar to MDN1: Midasin (Homo sapiens)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HICCMSTLAB_LOCUS9535</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5100401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="422220at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000055">
        <property type="term" value="P:ribosomal large subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011704">
        <property type="entry name" value="ATPase_dyneun-rel_AAA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48103:SF2">
        <property type="entry name" value="MIDASIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48103">
        <property type="entry name" value="MIDASIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07728">
        <property type="entry name" value="AAA_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00092">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VWFA" evidence="4">
        <location>
            <begin position="3132"/>
            <end position="3324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="2300"/>
            <end position="2338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="2450"/>
            <end position="3000"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="2300"/>
            <end position="2309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="2310"/>
            <end position="2319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="2320"/>
            <end position="2336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="2467"/>
            <end position="2504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="2513"/>
            <end position="2523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="2524"/>
            <end position="2539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="2553"/>
            <end position="2575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="2576"/>
            <end position="2618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="2620"/>
            <end position="2631"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="2645"/>
            <end position="2672"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="2684"/>
            <end position="2699"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="2700"/>
            <end position="2718"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="2746"/>
            <end position="2759"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="2770"/>
            <end position="2793"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="2819"/>
            <end position="2830"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="2841"/>
            <end position="2869"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="2888"/>
            <end position="2904"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="2951"/>
            <end position="2964"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="2965"/>
            <end position="3000"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAG5100401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="3336" mass="384166" checksum="DA4147B112D0B5A8" modified="2022-05-25" version="1">MVRLNVSQSNLYFFQTDYNRHLEELIERTENLLINALRITLVKQNHQVSELYEQLEGIKQLSNEETLTTTMAIETKNFLHRTEELFRLISRMEKLKTLEAFEKVELTSINEKLQNLSKLVKQDNCLNAGGKFEWIDSVLVKCLQDGTWLLIDQVNLCSPAVLDRLNGLLEPGGVLTIGERGVDNDGNIHTIKPHSNFRLFLTMDSRYGEISRAMRNRGVEIFLLGHKECQSENELDTKSLMFDLGLTQNSHQEAMLNIHREILSQKLLTDKLSTIQLLHSAFLITQQILRGFAVKKAFTTACVDVYIKSRYIHNSKIKHHILSIINNIIDQYNITDNVSPTIDLHAITWNVRDLQDNVRLTIINQQATLLLSLINKYCQDVSLSTSTTEFLNKYLNPDGNKNLIAIDIKKIIPYLLLTFFEKSSTKDFTLRSSWLLEQLRNSHSDDLISSIECKIKAMTEEIQQTQIEKNLESSLPWYRCISDNSVKSNQNNAQLLSIRLYLKSMDIKYPQTLSAVVNKNIITLEKYSDRVCSNDEQCSSVAPIATFFVPFLTLVNRWINTYFKDLCDCSNNNKYIELRQDLQWFRRFYEQGQLTFINKLRRENEKIESDHTEMLLKVHYRWLRKLLIRTFEECDDLVRNENEHTIESLKEFMSEFDDYLRDQQSFKKLTKKVKEQLNILHPFTSEAIIKYYRELVSNSEDRFLPRNTEFSYQLNLVFRQLEETKNIRFELTKLWENIFNDEFNEETAKDVMTKIELLLEEYQLLSSFKIKEFTEKILSTHSKKTLIEMSSNVQLWPVYQHTFVIFAHKLHCQLNEAFNGSITINSSLINKFNHLSCVPVNLIAVLSTLINKSGERENCERLLPELFRYLTQYKGRNTYNHSKFINYLMSGFDEDLNSGEFIESNDKFNYCDNYPVLINTLSDLLLSKNSKENFIVSTAPIGFYNTHIQQISTINSMLWRNSISFNSDQYNLILNDCKAFKCYADIYLTVIDKVEKTYDVSKLITYNDKQNSQGNCENIYEICYKNPVEKMKSIKSNWDNECNYKTEAFDRGMGWVYLGFHQYFLFSHLGFIDPVLKTELKLKYINDDIEDLENLIYANTLDSYLLDDEGWMGHGGESSRVASAKKCLDILYDVQGELAKSTGYRSSDVRFVDLSRKMSRFRDDIGTAKNIITSCENLCNIIVNSMMGNGYLNKSNEFELTTAVNVLINQKNTWQRFYKSLEKEFLPYYRELVSPIINGLNKIIHGGNILIKEANRLISREKTSIGVATKKLSAQNLLYNLVRFPTIGTDQENLLKLIDFHTSQNSKEFIMKYVGKSDKSKSYLEVFRVLKSSLSELYNHITLTKQLSKPLWNKLNELLSQICLVWKKQQMELEKAAAESQSLYKGSVSIHCQTLSDEEEINQQLRQLFPITQEFDDIQEVRTLEAQTNCKDSSKTIDSFVNVITDDDLEEVYKIHSLIVKSYASASWLKHSDFIRLPSRNYIDPLIQRYHTFGLLRPEVEQSFSADLSTKLHTSFNVLASFAVSTSLGENYHVNENDVKNKSYDFYKNSNIEQVKKCVPILVGLTEIVEAYLVEWPGQPTLESIQMIITRINNFPITSSVSRFLMGLEILLSKTREWKEMSARKGDRLAEYALSLEQQIKDWRRLELGCWKDCLDSTFKRLQAKASKWWFFLYSIVESYVNKTSLKAEIPEDVKEKSGDDDDDDNEIVTAKKLIKLLEIFMNQSSLVEFQARLDLLLTFHSHVFHLDQSEERSELLAIFWNKYNYYHRFSDDVSKKINQLKTTVGKDVKDQVTIANRTKIDRWTVEELVKKVHRKLLDCIKKYETGLKESVGACLAIRSSNYSSEADKGEWDRSKIRDYSINPEDFIVSENNISEKYSLPSKGLRADTIKHFNEVKERCRRTILSSIYPGLRVELEEHIEALIGNAIRLKNMEVNRELPKEKQKSHAKSILQTKKLELKLYFDTLKSFGLSDNKGNSDWKNKPHEVLDMTVPPLDIQSTLERFESSTESDKQMLAHWNGSENYYYKSCIKLNALISTLTKIQTDLGPGNMERCKGYSVDIITKAHKQKRILSKSINIYATLRQQVSNLINVNTGNKKTSLPYHQDIAECATELNELLASLLIGLEQIELYIQACPRDLVTDDRVIILESSDLPLINATKGDQTWESANILIRDAIKSIGDVSTVHNKMFSSTPTVTLIRTHGHFDSLKNSCKSVEKISEVITTLGNMFGNEQIKYHPLLETIEFLTKQSKRWINKFNDIKTFDSDLTIKNDSVIQDVKTKIKYLVAIILHVVKKNEEASQSDSSSNELTHQDKKNIDDENKEEGEEEEEEEEEQSLLENNGFREQLIESLEKDIKSLEIEKVNKELENIIAVAQELNPEYISYYNSLLLTCLPLLNQYILFTHFYLTEQVAAFRVTCKLLYLQLNVFLDLATNGFCMPKDLDLENEADANGADEGQCKDGMGLGDGEGKKDVSDKIESEDQLEEARPAGEEKNEEDKDCKEEDNGIDMSENFDGKLQDLEKNENDEEDEGEENDDNDLEKEMGDTETGADQMTEDIWGDDTDQSDTEDQSEDTNEQGKGEQTDEKEFGARDDTKHQGEDKLDKNAEEEKEEKDKPEINEMNEPDINDDQIDPYHGKHNPQPEPEPMDLPDDLNLDGEDEDKDNVENEENPFDIDAMKESIPPENKDTDAADQEKRTDADENQGDDSSDEEGGPTVEDTEMKDLDGADPEVPETSDQQVPDKGDEKMEDDNPDKETEEEKGERAVPSTDDGSKETDTADQLENKVEGSRDKAANDQNLESQKDTAPVEENSQDDGNDKGTGQAQSNQQNDGHFGGIAEKNTTVEKRQEEQNLREKRKNPGESDENRALIDKAQPNKKKQRIINTREELENDNDDAEGAENEENGGIDMCQHVKNTEKFDDYATDAATEEQAKKQTIADEEEEPDARKEESMDVDMQEDKEEVIEEDVKKIDAEPTSKTDKDKTKSDSKNNREDISNAESKLDVEGDIVPTITVPQAIESAFYTNLKEDNFIDLTQEDEIIQKKTIKRWIHKPSSEEALATWNSVSSRTETAARDLSEKLRLVLEPTQATRLKGDYRTGKRINMRKIIPYIASQFRKDKIWLRRTKPSKRNYQILLALDDSSSMKDNLSHELTFESLSLISKAMEYLEVGDLGVVSFGERVEVLHALGKPFNEESGSRLIEEMSFEQKKTNIGEMINATVDMFEEQGGSTDSAKLLIILSDGRINESEEKLNLAVRRAQLANIFIVYIIIETPEKKHSVLDITKVIKLEDGVTYKLCSYMDSFPFKFYMVLRNISSLPGILSDALRQWFEIVGKIDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HNE3</accession>
    <name>A0A8J2HNE3_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Similar to Pgrmc2: Membrane-associated progesterone receptor component 2 (Rattus norvegicus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HICCMSTLAB_LOCUS10898</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome b5 family. MAPR subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5102204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HNE3"/>
    <dbReference type="OrthoDB" id="547796at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.120.10:FF:000003">
        <property type="entry name" value="membrane-associated progesterone receptor component 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050577">
        <property type="entry name" value="MAPR/NEUFC/NENF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10281:SF106">
        <property type="entry name" value="IP06960P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10281">
        <property type="entry name" value="MEMBRANE-ASSOCIATED PROGESTERONE RECEPTOR COMPONENT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0675">Receptor</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="36"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="4">
        <location>
            <begin position="76"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="173"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAG5102204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="201" mass="22451" checksum="07E3F2A15399BFA4" modified="2022-05-25" version="1">MAEPSVSPAPSSSDSSENLQEESFISSFIAEVVKSPLNIFLVIVIAILVYKIFRSKTQEDLPVQEHKELPKIRKDFNVEELKKYDGRGTDGRILVAVNGSVYDVTRGSRFYGPDGPYAAFGGRDASRGLATFSVVPGKDEYDDLSDLNTTEMNSILEWEEQFKERYDYVGKLLKPGEAPTNYSDEEDEGSQQESDVKSKDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HNK9</accession>
    <name>A0A8J2HNK9_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10">Glutamate--cysteine ligase</fullName>
            <ecNumber evidence="3 10">6.3.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9 10">Gamma-ECS</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8 10">Gamma-glutamylcysteine synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HICCMSTLAB_LOCUS11112</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-cysteine + L-glutamate + ATP = gamma-L-glutamyl-L-cysteine + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13285"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58173"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 10">Sulfur metabolism; glutathione biosynthesis; glutathione from L-cysteine and L-glutamate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the glutamate--cysteine ligase type 3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.2" evidence="3 10"/>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5102633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HNK9"/>
    <dbReference type="OrthoDB" id="7939818at2759"/>
    <dbReference type="UniPathway" id="UPA00142">
        <property type="reaction ID" value="UER00209"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017109">
        <property type="term" value="C:glutamate-cysteine ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004357">
        <property type="term" value="F:glutamate-cysteine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006750">
        <property type="term" value="P:glutathione biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.590.50:FF:000002">
        <property type="entry name" value="Glutamate--cysteine ligase catalytic subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.960">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.590.50">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004308">
        <property type="entry name" value="GCS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11164">
        <property type="entry name" value="GLUTAMATE CYSTEINE LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11164:SF0">
        <property type="entry name" value="GLUTAMATE--CYSTEINE LIGASE CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03074">
        <property type="entry name" value="GCS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="Glutamine synthetase/guanido kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 10" id="KW-0317">Glutathione biosynthesis</keyword>
    <keyword evidence="4 10 11" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU367135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAG5102633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="618" mass="70846" checksum="023513D4F3C79816" modified="2022-05-25" version="1">MGQLTEGKVLTWEEIKKIKDYVREHGIIQFINLYKRCKDKQDNDFKWGDEIEYTIVKFDDLEKSAKLNLISHKLIVELNKKENESPESVECLWRPEFSSYQIESTPGKPFGASLKDFNNVEANMLNRRVEAMEFLKPGERLITITSFPRLGCSNSSEPPGKPTPHSGLIRSLFVQEGTLFQGHKRWHAITENVELRRGEKIEINVPIFQDKNVPKPFREDFGPLGDDGEAQRLAKDDHVYMDSTGFGMGGCCLQATLLGRDLTEAQVLYDQLTIFCPVMVALTAAAPIFRGYLTEVDNRWIPSLGATDDRTRGERGLEPLKPRELLMRTGRNGSVEWYLSEEGQRYNDLPLSYDDKWVNLMMKNGVGKALAQHVAHLMSRDPVSILSTQIYVDDQTETTCFENIQGSTWRSMRFKPPPSNSDIGWRVEFRPMDIQMTDFENAAACCFVILLAKIVLHFNLNVLIPLSKVEDNMMRSQKRDAVNKEKLWFRKDITSHATDQPIDQEYDEFTVDEIINGKQGFVGIIPLINSYVDDMKVDAETRRTIDQFLNLFSKRAKGELLTDAAWMRKQVLTHPEYKHDAVVSERINYDLLKKIDLIARGHQTCPDLFGSHALKKLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HNP1</accession>
    <name>A0A8J2HNP1_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">ATP-binding cassette sub-family F member 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HICCMSTLAB_LOCUS11777</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ABC transporter superfamily. ABCF family. EF3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5103973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HNP1"/>
    <dbReference type="OrthoDB" id="2110130at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03221">
        <property type="entry name" value="ABCF_EF-3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000467">
        <property type="entry name" value="ATP-binding cassette sub-family F member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000104">
        <property type="entry name" value="ATP-binding cassette sub-family F member 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032781">
        <property type="entry name" value="ABC_tran_Xtn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050611">
        <property type="entry name" value="ABCF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19211:SF15">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY F MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19211">
        <property type="entry name" value="ATP-BINDING TRANSPORT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12848">
        <property type="entry name" value="ABC_tran_Xtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0007">Acetylation</keyword>
    <keyword evidence="5 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="90"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="402"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="39"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00073918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAG5103973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="631" mass="71272" checksum="D9B09B7C52895196" modified="2022-05-25" version="1">MPSDAKKKQQAKKKEAAKARQTGKKPTSTNPTKEDGKEQTNASANDENGTNGVLSAEEALCLKLESDARLNAEARACTGSLASHPRSRDIKVSNFSITFHGCELLQDTNLELNCGRRYGLLGQNGSGKSTLLSVIGNREVPIPESIDIFHLSREMPASSKTALQCVMEVDEERVRLEKLAEELVDCPEDDAQEQLMDVYERLDDMSADTAEARAAHLLHGLGFTTKMQNTATRDFSGGWRMRIALARALYVKPHLLLLDEPTNHLDLDACVWLEEELKTYKRILVIISHSQDFLNGVCTNIIHLNKKLLKYYTGNYEAFIKTRAELLENQSKQYQWEQDQIAHMKNYIARFGHGSAKLARQAQSKEKTLAKMVAQGLTEKVSTDKVLNFYFPSCGGIPPPVIMVQNVSFRYNDDSPWIYKNLEFGIDLDTRLALVGPNGAGKSTLLKLLYGDLVPTTGMIRKNSHLRIARYHQHLHELLDLDMSPLDYMLKSFPEVKEREEMRKIIGRYGLTGRQQVCPIRQLSDGQRCRVVFAWLAWQVPHLLLFDEPTNHLDMETIDALAEAIADFDGGMVLVSHDFRLINQVAEEIWVCENGAVTKWQGGILHYKEHLKNKVLKDNQTRAKELLNRGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HNW1</accession>
    <name>A0A8J2HNW1_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Dephospho-CoA kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HICCMSTLAB_LOCUS11944</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CoaE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5104322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HNW1"/>
    <dbReference type="OrthoDB" id="247245at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004140">
        <property type="term" value="F:dephospho-CoA kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02022">
        <property type="entry name" value="DPCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000485">
        <property type="entry name" value="Dephospho-CoA kinase CAB5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00376">
        <property type="entry name" value="Dephospho_CoA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001977">
        <property type="entry name" value="Depp_CoAkinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00152">
        <property type="entry name" value="dephospho-CoA kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10695:SF46">
        <property type="entry name" value="BIFUNCTIONAL COENZYME A SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10695">
        <property type="entry name" value="DEPHOSPHO-COA KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01121">
        <property type="entry name" value="CoaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51219">
        <property type="entry name" value="DPCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="207"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00044157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAG5104322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="234" mass="27165" checksum="2F419E64BC812CFE" modified="2022-05-25" version="1">MFIVGLTGGIATGKSSVCEIFREHGIPVVDADVAARRVVEPGKTAWSKIRKQFGDEVFDDDGYLDRSKLGDLIFNDIEKRRKLNAITHPEIYKELWWETLDYFFQGYPYIVMDLPLLFETGKMQNYLYKIIVVTCEEDQQLERLMKRSDIDEEKSKQRITSQMPLDKKIEQANFVIDNSGSREETKKQTIKIINLLNSYKQHWRIRFTLGVFCVVLVGGIYCLATRFLMDGSNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HP05</accession>
    <name>A0A8J2HP05_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS12818</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5107587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HP05"/>
    <dbReference type="OrthoDB" id="8113027at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5107587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="197" mass="22261" checksum="BE1A83CF9A268675" modified="2022-05-25" version="1">MGTLSEATGGAGGNPNNPGAKDQNIYENRAGTKKLIRVVTVIAYLFSSVNTIKLRNPIIEKIYHESDKVTTTSDLQTSIYDIINKHLDPSNDDKKTTDKSTVFTKIENTTETTVLLTPSTEMNKYYEKDENNFTSTSTSTPTPTTKIEFLNKIFDKNRQPPENNQLNTEITTDESNYQTTENLYFQGKKKIYLEILI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HPH6</accession>
    <name>A0A8J2HPH6_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="22">Kainate 2 (Homo sapiens)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">HICCMSTLAB_LOCUS12999</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="15">Postsynaptic cell membrane</location>
            <topology evidence="15">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5107961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HPH6"/>
    <dbReference type="OrthoDB" id="5984008at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045211">
        <property type="term" value="C:postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015276">
        <property type="term" value="F:ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038023">
        <property type="term" value="F:signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.190.10:FF:000167">
        <property type="entry name" value="Eye-enriched kainate receptor, isoform B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000067">
        <property type="entry name" value="glutamate receptor 2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.190.10:FF:000060">
        <property type="entry name" value="Glutamate receptor ionotropic, kainate 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.190.10:FF:000210">
        <property type="entry name" value="Glutamate receptor ionotropic, kainate 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.190.10:FF:000072">
        <property type="entry name" value="glutamate receptor ionotropic, kainate 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019594">
        <property type="entry name" value="Glu/Gly-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001508">
        <property type="entry name" value="Iono_Glu_rcpt_met"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015683">
        <property type="entry name" value="Ionotropic_Glu_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001320">
        <property type="entry name" value="Iontro_rcpt_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18966">
        <property type="entry name" value="IONOTROPIC GLUTAMATE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00060">
        <property type="entry name" value="Lig_chan"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10613">
        <property type="entry name" value="Lig_chan-Glu_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00177">
        <property type="entry name" value="NMDARECEPTOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00918">
        <property type="entry name" value="Lig_chan-Glu_bd"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00079">
        <property type="entry name" value="PBPe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="18" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="14" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="13" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="9 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0628">Postsynaptic cell membrane</keyword>
    <keyword evidence="10" id="KW-0675">Receptor</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0770">Synapse</keyword>
    <keyword evidence="4 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 19" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="269"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="346"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="524"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="domain" description="Ionotropic glutamate receptor L-glutamate and glycine-binding" evidence="21">
        <location>
            <begin position="81"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="Ionotropic glutamate receptor C-terminal" evidence="20">
        <location>
            <begin position="139"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="domain" description="Ionotropic glutamate receptor L-glutamate and glycine-binding" evidence="21">
        <location>
            <begin position="149"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="224"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="229"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="396"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="397"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="445"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="site" description="Crucial to convey clamshell closure to channel opening" evidence="17">
        <location>
            <position position="375"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with the cone snail toxin Con-ikot-ikot" evidence="17">
        <location>
            <position position="402"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="457"/>
            <end position="513"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00034104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR601508-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR601508-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR601508-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="SMART" id="SM00079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="SMART" id="SM00918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="CAG5107961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="668" mass="75627" checksum="289942C3B4A47625" modified="2022-05-25" version="1">MPSPYAHPVPVETKGISGPIEFKEGRRIQFKLDLLKLKQHSLVKVGEWRPDSGVNITDVSAFFEQGIVNVTLTVITIPEKPYVMMHKEKNYTGNNRFYGFCVDLLEAVSKGVGFNYRLELVEDRKYGAKDPETGEWNGIVNELMRHEQPYVMLRNTGNFSGNERYEGFCIDLLREIAQMVGFTYKIELVPDGKYGVYDYETGEWNGIVRQLMDKKADLAVGSMTINYARESVIDFTKPFMNLGISILFKVPTSHPARLFSFMNPLAIEIWLYVLAAYVLVSVTMFVVARFSPYEWNNPHPCHSGPTEIVENQFSLANSFWFTIGTLMQQGSDLNPKATSTRIVSGVWWFFTLIIISSYTANLAAFLTVERMITPIEHAEDLAGQTDITYGTLDSGSTMTFFRDSMIETYKKMWRFMENKKPSVFVSTYEEGIQRVLQGDYAFLMESTMLDYIVQRDCNLTQIGGLLDSKGYGIATPMGSPWRDKISLAILELQEKGEIQMLYDKWWKTPGDTCMRTEKGKENKANALGISNIGGIFVVLLCGLAFAVLIAIFEFCYNSKRNSISERSTSSAQPPPTCSGSLQAIPQSMQQQNQQQESLCTEMMRELYRALRCRSSSQRRRACEKCSTHVVGYPLDNISATPFNGMRSQQSNLGVANELPPSHIHLHHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HPQ6</accession>
    <name>A0A8J2HPQ6_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="16">CYP6AQ23</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">HICCMSTLAB_LOCUS11806</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Microsome membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5104045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HPQ6"/>
    <dbReference type="OrthoDB" id="2789670at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11056">
        <property type="entry name" value="CYP6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000042">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050476">
        <property type="entry name" value="Insect_CytP450_Detox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24292">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24292:SF45">
        <property type="entry name" value="CYTOCHROME P450 6G1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 13 14" id="KW-0349">Heme</keyword>
    <keyword evidence="10 13 14" id="KW-0408">Iron</keyword>
    <keyword evidence="12 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 13 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0492">Microsome</keyword>
    <keyword evidence="11 14" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="9 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="13">
        <location>
            <position position="453"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CAG5104045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="508" mass="58661" checksum="698439E7AFF6C5EC" modified="2022-05-25" version="1">MAFFTRSWILDLLILVIGLIVFTYLYMTRKFKYWKNRGVFELTPTAFVGNFGDCLMTKKNAGEWIKDMYDKCSGLPFIGFYVFDRPCLLIRDPKLLKQILVKDFNAFSDRFVSASPHDRIGDANLFIIKNPQWKLVRTKLTPIYTSGKVKKLFELMDVVGDDLLTLMESENLEGEGKELELKDLCARFTTDMIATTAFGIRANCLNDPKAEFREYGRKILETSFKRNFEILSIFFLPQFLTLFKIEFLPRETADFLRNTLWEVIRERERQNFQRGDLVDLLIELRNNKTEIFKDEFDFDGDNLLAQAVVFFTAGFETSSSALSFTLYEISLQSKIQDRLRAEIIEGLEKTDGKVTYDLASSLQYLDMVISETLRKYPPLPVLDRVATEDYKIPDSNLVLKKGTPIMVPMLGLHYDPEYFPDPEVYDPERFSEANKKKILPCTYLPFGEGPHNCIGMRIGMLQTKLGLIKLLSKYEFTPCKRTLIPMRLSKKALLATADGGVFLQVKKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HQH7</accession>
    <name>A0A8J2HQH7_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HICCMSTLAB_LOCUS12640</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5107220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="7989901at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="1393"/>
            <end position="1414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="81"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="404"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="536"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="651"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="687"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1328"/>
            <end position="1364"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1089"/>
            <end position="1116"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1172"/>
            <end position="1199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="53"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="96"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="146"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="158"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="423"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="536"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="691"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1350"/>
            <end position="1364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG5107220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="1415" mass="159497" checksum="E6E591715F332EB3" modified="2022-05-25" version="1">MEKWRCRGKNTGAKVKVTEENAAPQKPSTESQPEKKKEKKWTFAGLLKRKSKQTASSEQSNSLLSLTPNPTIYYSEQVKNVQTNPPSKADRDKSHNNYNKQTTGNATKKQESTDSMNLSNASTSAVAPPATIQSRNSESSDTGSKYSRRNRLKARIQAKRDRYYGDSSTDDEHSHYKSSNNSNSNCYINTNSIVNGNANITATAAATATNPNNSLMRIQSEDSIYHHHHHHHHHHQQHHNNNNYHRRLIEANKKTRGARTVRYMKRFYRDDTIDDNDGNIDVRIHPIYHHVSPVLPVSHSNNYNYNYNNSNNGIVKKKADTLPSTNNLWTTTNNNNLLLKPPYYQAFCSEQNLLHVYPNNYNDNIKYQSDNLHGLNDNEVFNNEYAWPQPHEAKLTTATSNYNKSRGINCHVDNKSPPPPAPASSSVSPASASVLAPQPPPRSTSVSRLHPVASARHSHHLDLDIFTETNSCSGCSNNHHNHNHSCSQQLLPCGSNVNYNSLDRIYATPKRRHRCCNRRVVRHPISEPFLLYKNNNSSSINNNNNNNNNNTFSKKSHEVEDKMPEDPIVPKIKKKIVPKMKGYKSIYEQPLEKRRHSKNLEEALIELETIYNSLHLNEDEDLLDRAEQRSMEEYRDKIAITAAAKAGIGGSIKSSLDTSSSSSPSPSPSAASSYELNLWRNVNFDRHDNYSNNHNHNNSHSHNNNNNNNNNNNNNNNNDDEPRLKDDMAYRRMHQPERSASVDPSQSSLSRVSYLAASPSLLSYKDREYQIDNNYLLGNYVNVSCNNEKPKNQRRGTPDLTLDDVVYRNITHANNTLRVIEPQPPFGIPLGPVTAAAESDYLHVEPKIKHTRSSLYIPKNEPDIVTDDLAFRNLRKDTNGKNKFANSMNNISFVPTRESMSRSILAGNCDLKKKRAVRSLSADLYGIIDKSNDDHDAWYKEFTKVNSSKLFPQDGALISSNSVGDISIGNYNNNNNNNNNNDDDHFYGKDKNSDLDINGNRPKSLYQAKIQVCVPHEEDGKVLRRKSCEREFMEMENCQTFDKKSRTLSSPYYGGGSFDVDVDEGDGGGGGEVVDTNEKVIEPSSDQELSEYKQLCRNLESLIKKTSEKVKKSVEEAKSNAMLLGSNRNSLSEFIEWEELLGEDESLKINKKVIEDEEDGKAKGEGKGNEVKEKIRMDKEELEKTIKEIKDDTKSEYKEPDQLLKLNIDDETGTKVIDTEASCESYNSNKESLESVVKLVPSNDAQDNISLDDYDNSHVDYHACNNDVDCDDDKQPNAEEFHLDKQVPYLSCDSTKLNDDNNFDNDFKNLISSDSHTNIDEGVDVAAASDDKKEPALKQPETADSNPSELEVHAGQKDDTEKTCKGENTGNSGILAEAFIQPIINVCFYTNCFSTYSIALWSLCLTLLIAIIAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HQK5</accession>
    <name>A0A8J2HQK5_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Serine/threonine protein phosphatase 2A regulatory subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HICCMSTLAB_LOCUS12456</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the phosphatase 2A regulatory subunit B56 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5106830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HQK5"/>
    <dbReference type="OrthoDB" id="10264446at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000159">
        <property type="term" value="C:protein phosphatase type 2A complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072542">
        <property type="term" value="F:protein phosphatase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000010">
        <property type="entry name" value="Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002554">
        <property type="entry name" value="PP2A_B56"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10257">
        <property type="entry name" value="SERINE/THREONINE PROTEIN PHOSPHATASE 2A PP2A REGULATORY SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10257:SF5">
        <property type="entry name" value="WIDERBORST, ISOFORM H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01603">
        <property type="entry name" value="B56"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028043">
        <property type="entry name" value="PP2A_B56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="16"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="403"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR028043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG5106830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="426" mass="49897" checksum="1DC8663008A1BCB1" modified="2022-05-25" version="1">MSSATFVDRIDPFSKRSLKKKSKKSQGSSRYRNSQDVELQQLPQLKDVTPSEQEELFIRKLQQCCVAFDFMDPVADLKDFDPEEDDPTLEASWPHLQLVYEFFLRFLESSDFQPTIGKKVIDQKFVLQLLELFDSEDPRERDFLKTVLHRIYGKFLGLRAFIRKQINNIFLRFVYETEHFNGVGELLEILGSIINGFALPLKVEHKQFLVKVLLPLHKVKCLSLYHAQLAYCVVQFLEKDATLTEPVVRGLLKFWPKTCSQKEVMFLGEIEEILDVIEPSQFVKIQEPLFRQIARCVSSPHFQVAERALYFWNNEYIMSLIEENNHVIMGIMFPALYRISKEHWNQTIVALVYNVLKTFMEMNSKLFDELTASYKSERQKEKKREKERDELWKKLNELEIERRGAIMGTPNTPVPATPVSATRARP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HR18</accession>
    <name>A0A8J2HR18_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DNA-directed RNA polymerases I, II, and III subunit RPABC3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HICCMSTLAB_LOCUS13684</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="5 7">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the RNA polymerase I (Pol I), RNA polymerase II (Pol II) and RNA polymerase III (Pol III) complexes consisting of at least 13, 12 and 17 subunits, respectively. Directly interacts with POLR2A.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the eukaryotic RPB8 RNA polymerase subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5109048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HR18"/>
    <dbReference type="OrthoDB" id="10249565at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005736">
        <property type="term" value="C:RNA polymerase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000073">
        <property type="entry name" value="DNA-directed RNA polymerases I, II, and III subunit RPABC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005570">
        <property type="entry name" value="RPABC3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10917">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10917:SF0">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03870">
        <property type="entry name" value="RNA_pol_Rpb8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000779">
        <property type="entry name" value="RNA_pol_Rpb8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00658">
        <property type="entry name" value="RPOL8c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="4 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00044496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00062890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR000779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG5109048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="151" mass="17180" checksum="F314BDAC3BA2A0B8" modified="2022-05-25" version="1">MAGVLFEDIFNVKDIDAEGKKFDRVSRLHCESESFKMDLILDINSWLYPMELGDKFRLVLATTLREDGYPDGGDWTAIEQEGGSRADSFEYVMSGKVYRMEGDESTNEPGSRLSAYVSFGGLLMRLQGDANNLHGFEIDQHMYLLMKRLAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HS67</accession>
    <name>A0A8J2HS67_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similar to Allergen Tha p 1 (Thaumetopoea pityocampa)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS12346</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5106611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HS67"/>
    <dbReference type="OrthoDB" id="6355718at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.2080.10">
        <property type="entry name" value="Insect odorant-binding protein A10/Ejaculatory bulb-specific protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005055">
        <property type="entry name" value="A10/PebIII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036682">
        <property type="entry name" value="OS_D_A10/PebIII_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11257">
        <property type="entry name" value="CHEMOSENSORY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11257:SF13">
        <property type="entry name" value="GEO07322P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03392">
        <property type="entry name" value="OS-D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100910">
        <property type="entry name" value="Chemosensory protein Csp2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035222827" evidence="1">
        <location>
            <begin position="19"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5106611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="125" mass="13838" checksum="C070086D62B524AA" modified="2022-05-25" version="1">MKLLVVFLSLIGLSVVSSGSSDYSQLPSNAEILKAMENSRIRQPIFKCLMGTGTCAGNGGKVKKFLLEDIKNNCNACTVSDKKRAVNLMKEIRSLYPVDWAKLVAKYDPHGVYERKLLAQIENQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HU03</accession>
    <name>A0A8J2HU03_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Similar to gsb-n: Protein gooseberry-neuro (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HICCMSTLAB_LOCUS13497</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the paired homeobox family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5108861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HU03"/>
    <dbReference type="OrthoDB" id="3225452at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007365">
        <property type="term" value="P:periodic partitioning"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000031">
        <property type="entry name" value="Paired box protein Pax-7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043182">
        <property type="entry name" value="PAIRED_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001523">
        <property type="entry name" value="Paired_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043565">
        <property type="entry name" value="PAX_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45636">
        <property type="entry name" value="PAIRED BOX PROTEIN PAX-6-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45636:SF3">
        <property type="entry name" value="PROTEIN GOOSEBERRY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00292">
        <property type="entry name" value="PAX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00027">
        <property type="entry name" value="PAIREDBOX"/>
    </dbReference>
    <dbReference type="SMART" id="SM00351">
        <property type="entry name" value="PAX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00034">
        <property type="entry name" value="PAIRED_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51057">
        <property type="entry name" value="PAIRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0371">Homeobox</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0563">Paired box</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Paired" evidence="10">
        <location>
            <begin position="32"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAG5108861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="173" mass="19173" checksum="C0D4C49E6C81CF59" modified="2022-05-25" version="1" fragment="single">MDITGGTKSLYGGYQFQASMKNIIRHIKRKHRQGRMNQLGGVFINGRPLPNHTRLRIVEMAAAGIRPCVISRQLRVSHGCVSKILNRYQETGSIRPGVIGGSKPRVATPEVEARIEEIRRLDPTIMNSQIRDKLIKEGFTDPPSLSSINRLLRGGRTGDDGKKDYTIDGILGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MAE0</accession>
    <name>A0A8J2MAE0_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to rg: Neurobeachin (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS2757</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001117">
        <property type="protein sequence ID" value="CAG5078490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="26681at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008104">
        <property type="term" value="P:intracellular protein localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000010">
        <property type="entry name" value="neurobeachin isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050865">
        <property type="entry name" value="BEACH_Domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010508">
        <property type="entry name" value="NBEA-like_DUF1088"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031570">
        <property type="entry name" value="NBEA/BDCP_DUF4704"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023362">
        <property type="entry name" value="PH-BEACH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13743">
        <property type="entry name" value="BEIGE/BEACH-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13743:SF162">
        <property type="entry name" value="NEUROBEACHIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06469">
        <property type="entry name" value="DUF1088"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15787">
        <property type="entry name" value="DUF4704"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51783">
        <property type="entry name" value="PH_BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BEACH-type PH" evidence="2">
        <location>
            <begin position="2405"/>
            <end position="2460"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="882"/>
            <end position="905"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="988"/>
            <end position="1016"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1060"/>
            <end position="1295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1396"/>
            <end position="1491"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1752"/>
            <end position="1789"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1818"/>
            <end position="1929"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1946"/>
            <end position="2073"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="882"/>
            <end position="893"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="894"/>
            <end position="905"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1070"/>
            <end position="1082"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1091"/>
            <end position="1138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1139"/>
            <end position="1150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1151"/>
            <end position="1165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1172"/>
            <end position="1193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1217"/>
            <end position="1228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1229"/>
            <end position="1287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1440"/>
            <end position="1465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1850"/>
            <end position="1862"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1869"/>
            <end position="1879"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1880"/>
            <end position="1890"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1975"/>
            <end position="1985"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="2009"/>
            <end position="2023"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="2060"/>
            <end position="2072"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5078490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="2460" mass="278263" checksum="CA39B46883E40DD8" modified="2022-05-25" version="1" fragment="single">AIVLPPMARWPHESGFTFTTWFRLDPINSVNIEREKPYLYCFKTSKGVGYSAHFVGNCLVLTSMKVKGKGFQHCVKYEFQPRKWYMIAIVYIYNRWTKSEIKCLVNGQLASSTEMAWFVSTNDPFDKCYIGATPEVDEERVFCGQMSAIYLFSEALTTHQICAMHRLGPGYKSQFRFDNECYLNLPDNHKRVSDELDNSSMVDQSMQTVLYDGKLSNAIVFMYNPVATDSQLCLQSAPKGNVSYFVHTPHALMLQDVKAVITHSIHSTLNSIGGIQVLFPLFSQLDMSYDCIAPNDIKRDPMLCSKLLGFICDLVETSQTVQQHMVQNRGFLVISFMLQRASREHLTTEVLASFLELTKHLVTCLSANSDLLLKQLLDHVLFNPALWIYTPAPVQTRLYSYLATEFLSDTQIYSNVRRVSTVLQTVHTLKYYYWVANPRAKSGITPKGLDGPRPQQKDILTIRSYILLFLKQLIMIGNGVKDDELQSILNYLTTMHEDENLHDVLQMLISLTSEHPSSMVPAFDSKQGVRTIFKLLAAESQLIRLQALKLLGFFLSRSTHKRKYDVMSPHNLYTLLSERLLLNEETLLLPTYNVLYEIMTEHISQHILYTRHPEPESHYRLENPMILKVVATLIRQSKQTEQLLEVKKLFLSDMTLLCNNNRENRRTVLQMSVWQEWLIAMAYIHPKNTEEQKISDMVYSLFRMLLHHAIKHEYGGWRVWVDTLAIVHSKVSYEEFKLQFAQMYEHYERQRSDNITDPEVRQQRPISTISGWDQQHATSNGNAINGNGAIENGDEGYRNWNEDHAIERNYKEYDAIEVNEVESNERLEETCSCDLNSIDNTEDSEGSPSIAVKSRDVVSIDSRLSEMEKIDSCVIGNHVGEDECDKEEEEEEEKEKVVEGKEDEGGLEVKIEEIVEDKVEEEKDDKKIDCKESEKDVVGVEEVVEEVGEKIEGVPEEIKEAEEIKVEAEEVEEIEVKKVEVEDDIDNKNIKNDDNQTDVIDSKNIDNDNAKDNEDVKEKIEENLVEEEKEINKINVSNVIEEIDVEKNEIKEQESNEVALKVENNEVADEEKKEISDFKESNDVVDSIDNVNKDVDENKEEDVKENKVDVVDKSNDGDKAEESKEQQEEEKEEIKDEEIVVTETDNEADKEDLVDKTDKTEKVDDTFDDTLGSKSIDCSTSVIKSTDDCTSVKSDGENKLKGDVINGESGEDKIEEEKEEEKEEEKEENDVKEVEGEGDQVEVKEVEKEDQDKQEEGEVKKEEEEKAVEEKNKYKEEVETSKGEHSSEPSNISTSISETIVPVNEDVEINDINNSKNVNMNTVKVDDDNMQVPNTTQTELQQQIPTISTVCDATKSLSDGVPQVISSVLAMDNPLNSSVNDVQLSTITADVAVDHEHVDPHRRSSLPNVTTSEADTDPSCAGVSANADKPIVLNGDTKRTVNMPSKKISSPQKRPRSASTSTQVDPNHFESKRAKQGNGTNRPMFSPGPSRPPFRIPEFKWSYIHQRLLSDVLFSLETDIQVWRSHSTKSVLDFVNSSENAIFVVNTVHLISQLADNLIIACGGLLPLLASATSPNSELDVIEPTQGMPIEVAVSFLQRLVNMADVLIFASSLNFGELEAEKNMSSGGILRQCLRLVCTCAVRNCLECKERGRTYSMLGRQIGTSNKSQHLQSLIRGAQTSPKNIVDNLTNQLSPVKDPEKLLQDMDVNRLRAVIYRDVEETKQAQFLSLAIVYFISVLMVSKYRDILEPPISQRPPSPVQTIQTNGANIRPASPTGDGNGGGGGRPLFPQWSHHVYPQFLPGTHPNANANLNANHHHISQHHHQHPLPPPTARHSNRQNPSNYYIPNHHTNHYNNHHHHHPNNNYNNYHRHHYYHHHNNNNNNNNNNNNNHHHALQKHNEPRNLYHRNSGVGLQESGGIMSQSGSQDDGEYEVIIVDENNSSILADHDVTSSGPPSTKGGHSGVPRSQPILEDYNTTSEPSIGSSKRPEVPRLTTKSNDSSEEAMHRSNLTADPSPSDITTDNENKHNSSEEAWTDVNLNEDADTIQINNSRDDPRNIHNITHSHGNQDNEGNVLEQETLGDAERGEKPTGEISVVRIPDRLVMTSASPRPDDLPIKSLVEHLPVPTPSREASLTQKLEMALGSVCPLLREIMVDFAPFLSKTLVGSHGQELLMEGKGLTTFKNSNSVVELVMLLCSQEWQNSLQKHAGLAFIELINEGRLLSHAMKDHIVRVANEAEFILNRMRADDVLKHADFESQCAQTLLDRREEERMCDHLITAARRRDNVIASRLLEKIRNILSNKHGAWGYMDPMAAKLTEFWKLDAWEDDARRRKRFVHNPLGSSHPEATLKAALEHGAPEDAILQAREEFHAHLAASRAHQQQLQSADLMDDSELLSDDRDLDNDLTGPINISTKGKIIAPGIVAPGIISITSTELYFEVDEDDIEFKKIDSEVSTFYYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MB30</accession>
    <name>A0A8J2MB30_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HICCMSTLAB_LOCUS3135</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5080905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MB30"/>
    <dbReference type="OrthoDB" id="5982876at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13912">
        <property type="entry name" value="zf-C2H2_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12874">
        <property type="entry name" value="zf-met"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="54"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="994"/>
            <end position="1021"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="1024"/>
            <end position="1052"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="133"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="347"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="500"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="648"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="836"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="870"/>
            <end position="910"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="926"/>
            <end position="988"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="163"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="183"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="228"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="255"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="348"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="500"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="542"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="552"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="675"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="836"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="884"/>
            <end position="901"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="926"/>
            <end position="951"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG5080905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="1137" mass="127228" checksum="00E571EF0AD6024C" modified="2022-05-25" version="1" fragment="single">VEMNSPIQEPDFDGFDFPEKNKIDTTEENETGLPILEEQINIVKSLERVSEELPQCEVCSQQFLTKKELRSHITLHLGQPRVVLKRCSNLHLVKKKEKDKYSLTQEKKGSLKLTLKKQNHRDFAVISRDLDFDSDNSESEEVAGLKKNNKNEKEEEEHEDTLDGNNGEQTDQPPHEFENVMVNEDDNYQDDNYDNNDEDNFLEDNEERPSVEINEGDSGVGSDMANTCEKDDQNVDDLHNVDNYQHEDDDRNNIEEPDDPEESDPIDATYRETIENLKKIGEQTSPDESSSDAMTSRINDNDALKLLSNNSAIELYPAKKTSSKPTKNNNEALRINSTMNWNQIENLSSRDNDSDEHVNKDGEASKDNADNSTEAGLLLQNLLTEHHHRKNNEERSSQNSSVETEYVSLERLAETVNKCRVCNEKFNDITMLDDHRLKAGHYQCNVPDCSSLVFTTSGELSLHKLQSHEPHNNNHPLSPTISIIPSQVNHQLSPRITESAASLGHNSPGMTNHRSPSTISPHTNSPHNLSPHPMSLDPLNPLQLNRSSPLASHQTHSPSYSSQHHHLQQQQQHHQQQDHHSLHHQQQMIPPINFDQLPPPVQQLAQQVQRMALPQSQMPPTLPPGANTMIPGPNYFVQPSGRPPMYHRMPGGPGHQPGSHPPHNMQYPPHLAHIYGPQYGGPYSQYPGPSQMHPQMQQQLQQMQQQQQQQQQQQQQQQQQTRGRYPPSMMANPRGPRPMVPNQVPRPRLKRPLLPQPPPAQGQPQQRGTEASTSKQRRMDLLIPDRNEDADCHVIAQQKRNDGVPIIQNVQGATGQPSTRNDSTIHLTDSITLSVRQPGSTPAQVQNPGTTPAKKTDAKAVANVLAARGITVTPTANKNKTGEQQKQQSPAQQQQQPQQPQRTAASTSPSVTALNLNSAISIIPASTQRKQQQASQQQQSQQQDQQFAVPQNKQSKQTNQEIERPPRPPTIDLTQESSPLMAHTRRGRPTRAALTCQICDKSFQNQEILVQHMASHRTSNKLDYKCNLCTAAYPTSQGLVLHKQSYHKELDSAPTNGGTELAIPVVDLKSPQTLSRLTSLGIQSYIPLSQLSAQTGGYFALPIVTIDSPRNPNSCNLGALGATSILSLGPLKHLSNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MEE1</accession>
    <name>A0A8J2MEE1_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Similar to smo: Protein smoothened (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HICCMSTLAB_LOCUS4341</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G-protein coupled receptor Fz/Smo family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5085316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MEE1"/>
    <dbReference type="OrthoDB" id="10064659at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042813">
        <property type="term" value="F:Wnt receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017147">
        <property type="term" value="F:Wnt-protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060070">
        <property type="term" value="P:canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035567">
        <property type="term" value="P:non-canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.2000.10">
        <property type="entry name" value="Frizzled cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015526">
        <property type="entry name" value="Frizzled/SFRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000539">
        <property type="entry name" value="Frizzled/Smoothened_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036790">
        <property type="entry name" value="Frizzled_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017981">
        <property type="entry name" value="GPCR_2-like_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11309">
        <property type="entry name" value="FRIZZLED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11309:SF126">
        <property type="entry name" value="FRIZZLED-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01534">
        <property type="entry name" value="Frizzled"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00489">
        <property type="entry name" value="FRIZZLED"/>
    </dbReference>
    <dbReference type="SMART" id="SM01330">
        <property type="entry name" value="Frizzled"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63501">
        <property type="entry name" value="Frizzled cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50261">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="128"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="160"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="217"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="259"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 2" evidence="9">
        <location>
            <begin position="124"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAG5085316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="385" mass="44714" checksum="F7332A0076566AF0" modified="2022-05-25" version="1">MLASDPTNVVFSVQASPCNLSTPLESYKQSLKKRCRYLCTEVENHCEELMSSDVWPEFLTCDNDDIFGDKDCVDPLESFEWNDESECPEYMVPSSIPTDAIAEFPGCRMGCHDPFYSDEEHLQMRVTIFWLSTICAGVNILSILTYLINWKSGTYPDRALFNLNWCSLLFCAGWLLQFFPFSTEDIVCNSDGSPRTSQSWSTLNTSRDLPCLVTFTLIYYSMMAMAMWFLILSFIWFMKFEAINRKSDKISGLFDVIGWWVPLFATFFMISFGLIDGISITGLFNGMSQEKSLKNYIMYGSKFKTFKRIKKFRTLSQKYFNSGVRFSTPSAKIMSVHWNNPNWWESSCKFWPCFLWVLQLYNASLDQVCCPILEKSFQLDFRKRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MFH9</accession>
    <name>A0A8J2MFH9_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS4760</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5088206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MFH9"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5088206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="144" mass="16797" checksum="7634F2C9B9F1EFBE" modified="2022-05-25" version="1">MNPSSIPLVLTNKTKQSRTIVLQKLYNKYIIILKKGNWFQISIIDLFNIEQQFRGNIININSHQSSRIFFASRRNYTPNISGSTTAWKVPDIRNDTRFNQTLRRIAVEVENREHIAEVVVAERSGNRIRIRIGITRSSFKSELH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MHX1</accession>
    <name>A0A8J2MHX1_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">EB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS5470</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5090047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MHX1"/>
    <dbReference type="OrthoDB" id="504708at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006149">
        <property type="entry name" value="EB_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39069">
        <property type="entry name" value="ECDYSONE-INDUCIBLE GENE E1, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39069:SF8">
        <property type="entry name" value="FI17111P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01683">
        <property type="entry name" value="EB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EB" evidence="1">
        <location>
            <begin position="18"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5090047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="221" mass="25705" checksum="8BEB9827B9CF7568" modified="2022-05-25" version="1" fragment="single">MLPEEFFVASNAENISAYTANHIGDACQTDRHCSELSNTRCQGGKCTCKDGTYQKVERCFYPRMFMIERDYEATVLAFESSLKNCTSDSDCGNMPNLHCFQGKCVCSKGFQLQNNECQEMTKSTCSKHYQCSHGTIRYYLNTCRYFNEFFSSDDADKYTTEGWESDCWTDRDCRDMNNTVCFENRYVCKSGYRRNFLTDKCQELPDRTCDNDDKCLYDTEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MKI3</accession>
    <name>A0A8J2MKI3_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">acyl-CoA oxidase</fullName>
            <ecNumber evidence="5">1.3.3.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">HICCMSTLAB_LOCUS5774</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the acyl-CoA oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.3.6" evidence="5"/>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5090869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MKI3"/>
    <dbReference type="OrthoDB" id="538336at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005504">
        <property type="term" value="F:fatty acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016402">
        <property type="term" value="F:pristanoyl-CoA oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033540">
        <property type="term" value="P:fatty acid beta-oxidation using acyl-CoA oxidase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055088">
        <property type="term" value="P:lipid homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.10:FF:000007">
        <property type="entry name" value="Acyl-coenzyme A oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.10:FF:000010">
        <property type="entry name" value="Acyl-coenzyme A oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.110.10:FF:000005">
        <property type="entry name" value="Acyl-coenzyme A oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055060">
        <property type="entry name" value="ACOX_C_alpha1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012258">
        <property type="entry name" value="Acyl-CoA_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002655">
        <property type="entry name" value="Acyl-CoA_oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10909">
        <property type="entry name" value="ELECTRON TRANSPORT OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10909:SF390">
        <property type="entry name" value="PEROXISOMAL ACYL-COENZYME A OXIDASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01756">
        <property type="entry name" value="ACOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22924">
        <property type="entry name" value="ACOX_C_alpha1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000168">
        <property type="entry name" value="Acyl-CoA_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13" id="KW-0274">FAD</keyword>
    <keyword evidence="8" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA oxidase/dehydrogenase middle" evidence="15">
        <location>
            <begin position="146"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA oxidase C-alpha1" evidence="16">
        <location>
            <begin position="293"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA oxidase C-terminal" evidence="14">
        <location>
            <begin position="501"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="12">
        <location>
            <position position="442"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="150"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="189"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="17">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000168-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR000168-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF01756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF22924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CAG5090869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="681" mass="77058" checksum="1C36789A5AF93387" modified="2022-05-25" version="1" fragment="single">GTNMKLLKIRELIRDIPTGGPLEVFRKRASFDWKSLKFNIFGVDSLEYHEKVYRFIESSPDFQRPSKTLTLDEYRRRCFNQIKTLFKNDLIESNGLSLNAYIDYDSSLPVIIGILYAMVPGVVFSLGTERHIDYVSKFHSGEYRGCFALTEVSHGTNAKGMRTTATYDIASQSFILNSPDFEAAKFWIGGLGKQATHAIVFAQLITPDEICHGLNIFIVPIRDPNTMLPMPGITIGDLGEKVGLNGVDNGFIMFHNFKVPRENLLNKMCDVTTNGHFISAIKDRSKRFGASLGTLSLGRANITNICFKYCSLAIVIAVRYCAVRKQFGPSATEEWPVLHYQALYGRLMPHLAATYAILIFSTTFLKQVQIFQAHLLNPETKDEAAAEGLEIHALSSATKPLCSWTVRDIIQDCREVCGGMGYLKVARLGDLRADHDANCTYEGENNVLVQQASNWLLNFTSNFSNGKPIPSPLKSIDFLAQGKKILQTKFTCMNMEETLEPENLQKAFQWLLCYYFEKTYRRVEILKSEGNDPFTIRNDSQTFYAKSLSLIYGEHAIFKSFIDKIEDPCLSNEEKIVLKKMCSLYGSSCLERWLGDLYSGKFADSTSKIDQFLREGIIKLSKELVNEAVSLVDILSPPDFILNSPLGMSDGEVYKHLEKSLRQNKENFDRPSWWKEMVAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MQF5</accession>
    <name>A0A8J2MQF5_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Similar to rbm46: Probable RNA-binding protein 46 (Danio rerio)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HICCMSTLAB_LOCUS10211</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5101138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MQF5"/>
    <dbReference type="OrthoDB" id="3800936at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12249">
        <property type="entry name" value="RRM1_hnRNPR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12250">
        <property type="entry name" value="RRM2_hnRNPR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000022">
        <property type="entry name" value="APOBEC1 complementation factor isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21245">
        <property type="entry name" value="HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="33"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="113"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG5101138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="463" mass="52933" checksum="6B0B51A085FE3C91" modified="2022-05-25" version="1" fragment="single">MNSTHYELVQENGQRRLTAPEFTKEYRDRIKGAEVFVGRLPRNCYEDELMPVLEKAGRLLELRLMLDFSGTTRGYAFAMYKDAKSAGRARAMLDGYEIRPGHRINVVKSVDNCKLFFGGVPKDKTKAEFIEELRKIFDGISNVYLYPNAEDPSLNRGFIFVEFKDHRSAAMARRKLIPGRVMLWDHEVAVDWAEPEPGESLDDEVMENVTALFIRNISRELPHQKVRDILHKATGIPIIKLKKINHFAFVHYKTRRMAQRVLEIASVSGGIADQTHWEFSWAKPIGSSKIQERQRAIQDALAGINLNDNQQSCSVWKPSLSYIKHQVAKKITKLADPSSPDISCMSPSTSNNSPDFTRAVIYPIRPPGSFPTNYKKLLEDLVIQNFDARCHFVCIPVLLTYGFICKIVHEFQGELYSTQDQAINVTSRVVYYKLVNNITQPLMVQPPVFKSTSFIPNRMETCH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MQJ4</accession>
    <name>A0A8J2MQJ4_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS11360</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5103139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MQJ4"/>
    <dbReference type="OrthoDB" id="7670874at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5103139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="471" mass="52691" checksum="9A8977B3C8E64D3F" modified="2022-05-25" version="1">MNTVSNLLAAVLLVNLKRSSRKVECPFAKLKSAKSSSSYRTPKCPFSSKQSSPEKSYKFINTCEESSDMSSFITLFGSIVEEIFIQVKTLMDIMPIALDNIKNQAILIPGLIEDVEITSNSCARTQKDLSGFFDFFGNIFKFSKPESDNYETEDVDVSGCLEKIKGHLMKFLGFLKPCMKSSGGVSVERISKIETLLEHLSPSKFKTLSPVCVSPPRIFKYPSLVHKHSGSSFGTCDESVSVTDQIYRLRELSTFMDQFPTIINEMMEAIRGVSQNHVQVKEVYPIPPSHSTLDYSHRASYKPCSTKPGSTEVHTYYKRPTVDIVEPPRIYQIPARTPISSCTGQSIINEIAMKTASDGRNFNIDASSISNMDLSNTKVTLDRSTVKSMLYEDNLNAGDVIIINITNDIMLVGAPFDDVSPIMFNIVYRKVSNKSPYNYKTTIWNLASQDFSCNQQIFNDILSDLTVLSTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MRB0</accession>
    <name>A0A8J2MRB0_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Olfactory receptor 217</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HICCMSTLAB_LOCUS11026</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5102460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MRB0"/>
    <dbReference type="OrthoDB" id="6597368at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005549">
        <property type="term" value="F:odorant binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004984">
        <property type="term" value="F:olfactory receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004117">
        <property type="entry name" value="7tm6_olfct_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21137">
        <property type="entry name" value="ODORANT RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21137:SF35">
        <property type="entry name" value="ODORANT RECEPTOR 19A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02949">
        <property type="entry name" value="7tm_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0552">Olfaction</keyword>
    <keyword evidence="8 11" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="9" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="32"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="64"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="125"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="177"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="255"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="336"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAG5102460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="365" mass="42675" checksum="647ED0E712317150" modified="2022-05-25" version="1" fragment="single">MEIFQENLTLLFFLGVWKPSEWNPGTVKSSLYSFYTILIIFLSYNFLITELLDLILVTNNVTEFINNFFMITAIFSACVKLVIFLRYRDKFNKIIDTLKKYLLNDSNTKEEMTIWKRSSNRIRSLTIFFIYANSIGMIFFTSGFVGNIKNRELLYRAWVPYNYSHPAKYSATVLNQLVAVIILSFTNIGFVLLFFAIMISICAQLSIFKLKFQRHFSYKDHPDDCYKNIYASKLIGEMVDTYHSITSLFGKVHGLFSWVILFEYCMGAVIFCTSAYHMSKMKVFSFEFLSCASYITEIMLDLFIVCFSCNEVTLELHGAFYNCHWYLLNNEDKKSLGFMMVNSIRPIYFTCGYVVYLSIESFTKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MRB9</accession>
    <name>A0A8J2MRB9_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Similar to Ets98B: DNA-binding protein D-ETS-4 (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HICCMSTLAB_LOCUS11421</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the ETS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5103261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MRB9"/>
    <dbReference type="OrthoDB" id="5961210at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08532">
        <property type="entry name" value="SAM_PNT-PDEF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000996">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000418">
        <property type="entry name" value="Ets_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046328">
        <property type="entry name" value="ETS_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003118">
        <property type="entry name" value="Pointed_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11849">
        <property type="entry name" value="ETS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11849:SF182">
        <property type="entry name" value="SAM POINTED DOMAIN-CONTAINING ETS TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00178">
        <property type="entry name" value="Ets"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02198">
        <property type="entry name" value="SAM_PNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00454">
        <property type="entry name" value="ETSDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00413">
        <property type="entry name" value="ETS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00251">
        <property type="entry name" value="SAM_PNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00345">
        <property type="entry name" value="ETS_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00346">
        <property type="entry name" value="ETS_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50061">
        <property type="entry name" value="ETS_DOMAIN_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51433">
        <property type="entry name" value="PNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PNT" evidence="6">
        <location>
            <begin position="348"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="domain" description="ETS" evidence="5">
        <location>
            <begin position="508"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="59"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="150"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="195"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="442"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="89"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="112"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="201"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="443"/>
            <end position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAG5103261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="596" mass="66560" checksum="08031EBA38F164D2" modified="2022-05-25" version="1">MIIEGCFAVIPTAVGFSPSFEYTAFQFDLSLLPDDYNSSATTHSQMTLKPIQIKQEVLSPRPDSPTTYPSPPYPGLTGALSPNYSREASPGYPSSPYYVPQSPQSAHLYPTSPEPSQPVKPPVKREKSLDLLTILQESRLLAESLGYKEDSTDCTVPCTPPRSEEDIYNSLDTDFFPKREETSNPLLKEILFKEEPTSTNSPQPTISHQSSISSQPSPAPDPENSSLRSLLFSSDNKQDTNPIDDNRHKTPLIIPKIEITDEDTFSSQKLSSPLSREDEIFNLKDQKSDHQLLREVLRDTSFQRKYNLRPVDLGTVGTGFVEDMENSECVGDLAREQIEPVLSLAIQQLQKDFDNTCVALGIHPEPRRWSAADVAAWVQWARRQLQLPSVPLDSFNIDGETLASLTEEDFCHRAPQCGSMLHAQLEIWKAAVEESPRNTLAASWSPTSVVQPSPVSTSDLNSSLSAPDASSSSASSCNLDLTDDEDDDVAAVTPVNDGGKIRNGGSHIHLWQFLKELLQSPGLHGSCIRWLDRTKGVFKIEDSVRVARLWGKRKNRPAMNYDKLSRSIRQYYKKGIMKKTERSQRLVYQFCHPYSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MRS0</accession>
    <name>A0A8J2MRS0_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Similar to erm: Fez family zinc finger protein erm (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HICCMSTLAB_LOCUS5899</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5092080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MRS0"/>
    <dbReference type="OrthoDB" id="6077919at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000005">
        <property type="entry name" value="Zinc finger protein 14 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000512">
        <property type="entry name" value="zinc finger protein 197 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001049">
        <property type="entry name" value="zinc finger protein 319"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001289">
        <property type="entry name" value="Zinc finger protein 574"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050717">
        <property type="entry name" value="C2H2-ZF_Transcription_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14196">
        <property type="entry name" value="ODD-SKIPPED - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14196:SF12">
        <property type="entry name" value="ZINC FINGER PROTEIN 208-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13912">
        <property type="entry name" value="zf-C2H2_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="165"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="193"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="221"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="249"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="280"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="37"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="329"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="47"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAG5092080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="790" mass="89298" checksum="A3952A2E28137012" modified="2022-05-25" version="1">MSQANSFQRNDWETEFDELRNIPDEVLSVYEVYVKGDSPQDERSNISSVSGVSSGSDQSLVQELDTGDKNVIKIFGKKLDPQPSKNKIQSEENIVESVAVPQISANDSSTSRLIDKDDPRSRLHFVKYLKREGKTLKIWECGTKEFRHQYTLMRHLPTHTDERNFKCEACGKAFRQLSTLSQHKAIHSDARPYVCDFCKKTFNRVSTLISHRKTHSENKPHKCNVCGKGFHQKGNLRNHVFTHTNERPYKCELCNKGFNQMSNLVCHKVKSHAHVEKMQYSCGICGKEFPKRFALRSHEEAKHGIKYRNPSASQSRVTQSKKNIRIVELPNDNDNDNDNNNDFLETGDSLTENDKGKKLTEGIDNILLDKIETKAMENTILMGQMPFALYKPVKGIPNKSVQVKVPVVATVIQIIDDSGNSTYKVEPPSDSEPEPAQGGIQFVRATEDGRYEVMSNSEARDLMEQNSHDVTILDGAEAEAINIFNARNSSQGQIADDAIDNQIMVLDAGAPQKPMLVDDIEIHDDKDIRILDSKSFAAEMAFFGGNKLNDFIFGNKPMGFDSGISMINADDDVNSQELSNLLEPTINSHSTFPLLSKSDSLFETLNYLKSNRIGDDYGILNVDTSCMDSMDTYEDLSDASLLSMAQDIKVVTPRPKVTLPSFADMKVLGPKYQEFEAASQMQDIKIFGGYDPYPKNFNGYRLDAYAAPPVSVPYVPSVPMTSEDLRIHDTYSRKTTSFDNKLLDNIDLQEEIFVKVENEMVPISSMWDEYDVDINDYWANHFYPMTAYDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MS30</accession>
    <name>A0A8J2MS30_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Similar to yrbE: Uncharacterized oxidoreductase YrbE (Bacillus subtilis (Strain 168))</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HICCMSTLAB_LOCUS12446</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Gfo/Idh/MocA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5106810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MS30"/>
    <dbReference type="OrthoDB" id="64915at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006740">
        <property type="term" value="P:NADPH regeneration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055170">
        <property type="entry name" value="GFO_IDH_MocA-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42840:SF3">
        <property type="entry name" value="BINDING ROSSMANN FOLD OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G10240)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42840">
        <property type="entry name" value="NAD(P)-BINDING ROSSMANN-FOLD SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22725">
        <property type="entry name" value="GFO_IDH_MocA_C3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gfo/Idh/MocA-like oxidoreductase N-terminal" evidence="3">
        <location>
            <begin position="45"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="domain" description="GFO/IDH/MocA-like oxidoreductase" evidence="4">
        <location>
            <begin position="176"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF22725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAG5106810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="371" mass="42210" checksum="AB762334DAF84AFF" modified="2022-05-25" version="1" fragment="single">MATIKFKEPSPYSKPKPRPPTEDYLYKIFEDDWSLKSNADADIIVKVAIFGAGRAGTIHLANIIHNPRMKLMYIVDDVEANWPKMKKHYRLNDVIFLNSKQSDKVFKDPNVDAVIVSSPTHTHEYIVTKSLEARKAVFCEKPIAENREQTEKCFEAARKAGRPLFTAFNRRFDPSYNAVRDRIRKGEVGHVHTIKIVSRDSPMPSIEYLKESGGIFHDCMVHDIDMMTWILGEYPIKVAVQASANVPEIKAINDFDTVVATLKFPSGTLGMIDLSRNACYGYDMRLEAFGPKGLVRAENEQPIHCVETMYNYNGPNTAPIWYSFPSRFRLAYQKELDHFIDVVLGKCEMIVKPKENLAVSKIASIVEESAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MSD6</accession>
    <name>A0A8J2MSD6_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">rRNA adenine N(6)-methyltransferase</fullName>
            <ecNumber evidence="12">2.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HICCMSTLAB_LOCUS12718</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11 12">Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="12"/>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5107376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MSD6"/>
    <dbReference type="OrthoDB" id="9895503at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034246">
        <property type="term" value="F:mitochondrial transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000179">
        <property type="term" value="F:rRNA (adenine-N6,N6-)-dimethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006391">
        <property type="term" value="P:transcription initiation at mitochondrial promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001737">
        <property type="entry name" value="KsgA/Erm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11727">
        <property type="entry name" value="DIMETHYLADENOSINE TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11727:SF13">
        <property type="entry name" value="DIMETHYLADENOSINE TRANSFERASE 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00398">
        <property type="entry name" value="RrnaAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF027833">
        <property type="entry name" value="MtTFB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51689">
        <property type="entry name" value="SAM_RNA_A_N6_MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 11 12" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 12" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="5 11 12" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="10" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4 11 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <feature type="binding site" evidence="11">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="152"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="195"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU362106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAG5107376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="419" mass="48940" checksum="AB6A7E5056029879" modified="2022-05-25" version="1">MSVKMKTNMFFRMFVTKTKYLAQKELRLLDNDQIETSQKLPFNEDTDLEVNKSDDLDEEVSLGNIKGNAKVIKALKDMGDVDVNRIPQICLSKVQSPKLLYLLNKNTAKDLASIIANDIIQSNVPVVEVNSGPGFLTEELLKAGVPRIYMNEKYEEFYWYLEPLLKKYGKRLSLRKYNLLQLSFIQSSDNRIIGNKMQDIFGGIDTKQWDQEPSMQIISIVPNKPFLYSVQYSMIDQYLSSFGRIILYIVTKPSIAKVFEDIPDSSLHKPRNIFLQTMFDSKVLGSLPRASFFPFNSNTKKKRPNLKLYIDDNEKMSVMRLEAKKDFLSDDFTKHDALMFLYFLKSHMRRRDARIIPELEKLMPGCGRQLIRHNLNIYSRFSELSSYQLFILFKIIKSWAQFENSSFVEDLKFRFEQET</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MSI1</accession>
    <name>A0A8J2MSI1_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS12659</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5107258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MSI1"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5107258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="63" mass="6930" checksum="80A79FA02E211EF9" modified="2022-05-25" version="1">MNNKARSSLSDPALATKALDRVRVRPQEIQTSSNLKSLSPTVVAHDLIAINYSAGNREKCFMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MSN7</accession>
    <name>A0A8J2MSN7_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Similar to rcc2: Protein RCC2 homolog (Xenopus laevis)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HICCMSTLAB_LOCUS11965</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5104364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MSN7"/>
    <dbReference type="OrthoDB" id="297375at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058923">
        <property type="entry name" value="RCC1-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028641">
        <property type="entry name" value="RCC2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46207">
        <property type="entry name" value="PROTEIN RCC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46207:SF1">
        <property type="entry name" value="PROTEIN RCC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25390">
        <property type="entry name" value="WD40_RLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00633">
        <property type="entry name" value="RCCNDNSATION"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00626">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="139"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="RCC1-like" evidence="4">
        <location>
            <begin position="178"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="191"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="243"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="319"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="418"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="23"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="46"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF25390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAG5104364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="488" mass="52434" checksum="08558F3D80129B99" modified="2022-05-25" version="1">MSTKRKNTPTSKKPKSKAKKVEYDEEDEISSPSDLEDADAGSNADGAEDAAAEEDLTDVTSIPELRAPEGGWGKPGTLVMCGLTNWEMAGRKAPPKGVKANVGRSLWSPHTFKNLNGARVRLIASGPSSAHNVIVTEDNRCLVFGKNDKGQLGLGDVKRRDDPTEVEALKGHTVIAAACGRNHTLFLTSRGIVFGAGDNKLGQCGVGKSDATILTATKVKYTGAPIVKVGCGAEFSMILDIKGGLHSFGSPEYGALGHNTDGKYFITNSKMAFHFEKVPKRIVLYVEKSKDGHVIPLDRVEISDFSCGYHHTVAIDSKSRAFSWGFGGVGRLGHNEQRDELVPRLIKFLEPPSRGVRSVHCGSTYSIAINVHGSALMFGQTKRTGEANMYPKPIPDLSGWEIRCVGVSQTSVVVAADESVIAWGASPTYGELGFGEMRKSSTTPMEVKALEGLYITAITCGLSHTMMISRDESEEEKAKLAELAVYSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MSX4</accession>
    <name>A0A8J2MSX4_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">folate gamma-glutamyl hydrolase</fullName>
            <ecNumber evidence="3">3.4.19.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HICCMSTLAB_LOCUS6883</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Extracellular space</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase C26 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.9" evidence="3"/>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5093501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MSX4"/>
    <dbReference type="OrthoDB" id="64220at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005773">
        <property type="term" value="C:vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034722">
        <property type="term" value="F:gamma-glutamyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046900">
        <property type="term" value="P:tetrahydrofolylpolyglutamate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015527">
        <property type="entry name" value="Pept_C26_g-glut_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011697">
        <property type="entry name" value="Peptidase_C26"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11315:SF0">
        <property type="entry name" value="FOLATE GAMMA-GLUTAMYL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11315">
        <property type="entry name" value="PROTEASE FAMILY C26 GAMMA-GLUTAMYL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07722">
        <property type="entry name" value="Peptidase_C26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51275">
        <property type="entry name" value="PEPTIDASE_C26_GGH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR615527-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAG5093501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="275" mass="31812" checksum="E00A66CF9DF1BFA3" modified="2022-05-25" version="1">MLLLRISVIQIMVIYFTQLIQSHYLITARSPLGYNDRPIIGIVAQEASYHLRNVYNNAYSSYIAASYVKYIESAGARVVPIRLGRHESYYEDIMSKVNGVLFPGGSTNFTTRNGFFDTVGKIYSKLFKHAPKNIIDILKNQSVTANFHKLCVTMKKLKEVNLSNTYHVLSVNYDDNGLRYISTMEHFNMPFYATQFHPEKNSFEWATRLRGIPHSKNAIRVGQYFANFFVDEARKNFHTFVSKEEESSTLIYNYPITYTGPTRSSFEQCYLFIDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MTA5</accession>
    <name>A0A8J2MTA5_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Separase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS7200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5093874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6776738at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1302"/>
            <end position="1329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1358"/>
            <end position="1400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1459"/>
            <end position="1518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1302"/>
            <end position="1311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1312"/>
            <end position="1325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1372"/>
            <end position="1398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1459"/>
            <end position="1476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1490"/>
            <end position="1499"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5093874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1533" mass="175865" checksum="9D98F24389E17EF7" modified="2022-05-25" version="1">MSETQLLRKWEDLLKAGKFEGLAQEIKEADIKPSNKLDTSWTRLLVVICHYVTSHEKISLSTATELTEIISAIHPKLLSISDPVKYFSSLYHVIRIFLFSKHHQEALKVTDHFLPGTVWSSAVEDPSYISKLTTLWATSLVSYLKSNKTRFEKATGLINYQLRLRLLCDPGEHRVFINDLDSYFLIIKSYEDEKYKEDFQSFILKIETLTDTKISLGTKDQYRTYESFLRLITDILSDKLNIKGINKISGKKIKQLFDLFREAVKPDCQIEECFAMYELLCSIFTRPVSAFDKFTVDTIETYIQTLDKIIKKYGIENAVHKNSNNASVLLQFVLIYWETYAKTKEKFGIPVELVPKLLSLIIHQADLFSQMEISSCNKCSSNKCTVKKDIWNSIGVKLRILLILSRIDATSKDLRQIGFSVFENCVTIVSELKENNCESWLKNWTPCCSRIFNIILQYDKNHYQDYIKFSELLCTKIKSFEVEKLLDPEENFLALCLHRLGSTHYHNENYRAAMEVASLSAYVGLSTGEGSSFRTWANCKYRYSSAKSMTMVECLESNKTAARFGITVLLDDSQKRQICLQEIKGLENCPMNMMSSILVVVELLQTLNPDPIEYAQAIHLLGYHQLDVQNSESLEKFLTTAKLELKKSPKTPSRQLLLGNLLFYLFIQKFGNIRRTIEAEMLTSTMRLSVKTRGDPASNVVPAYSLINITTSSNLEASLLRVLEFWTKYCQQEGLIESFGKYLTPKMMTRLVIIAGEYAKFYNFRGAEISAWQLAMSLASKFKDERSIMYICSRSIMSRYLITQWITLAEESAEKLKASCDEEIIESVAMLKFSLSSYYFYLGRINEAKKLFDEALETPGIKFTKNYPTYLYAMDILISERLNHDDCFNKHKYMQAIIEGLYTVILIEDNFLSSHNLPREDLLYRLDTAMEFTNHITLRMNSLLSYREISAHLIRRLKVVQKLGSTLHVAECLKNLCFLDLSRNQLEDCEVKLQGLEYILKLDSEKLDFEKATKSKKGVRVFCDNSPLRPVELVRDIPHNDGSPVLMTKIFSSPDFMEHEKDCKCFKCTNFAYKYFVFSCTHIRAQLYAAQNNVEQAVDHFHGALQIIKELIDFKVENFETVSQHYVEFVLFLLDFGKFIKYSVPNGGSDALSMVIYALSICEKHKIKNHPVYFNLKEFIFEARFQETFQADLYDKFVVSDTRAELGDEMAAGEDICATPVKGDARTIVEFKRRNTPPIITFTGASIDRFEEDNDCLTPVVTCDDQVKIVKKPSRITKVKPIRRKISDSEYLTPIGSRSNDLNSGICQASGDSKEEISENKEQSKDLNLNPPKIKIKSIKKANLDLNLLRKIQVKSEVTGGDGNSNVSKSRTRIENNCSERVKENSKATKEQKSKSELDDNVSDLEALQISDNSKVRKTRSGLTARAKTNLKVEAKNELDTVIEDLEAVHISQDITVEKSRSKSKDLSAKEIKSTQDRNFSTNTEKKKKVIDSENKEEIVENSSTEEPRRSRRLAVKKSEPGIDKFKILKQRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MTC3</accession>
    <name>A0A8J2MTC3_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Similar to NVL: Nuclear valosin-containing protein-like (Homo sapiens)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HICCMSTLAB_LOCUS13371</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5108706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MTC3"/>
    <dbReference type="OrthoDB" id="27435at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990275">
        <property type="term" value="F:preribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19530">
        <property type="entry name" value="RecA-like_NVL_r2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000149">
        <property type="entry name" value="Nuclear valosin-containing protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000600">
        <property type="entry name" value="Nuclear valosin-containing protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2010">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050168">
        <property type="entry name" value="AAA_ATPase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038100">
        <property type="entry name" value="NLV2_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031996">
        <property type="entry name" value="NVL2_nucleolin-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077">
        <property type="entry name" value="AAA-FAMILY ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077:SF171">
        <property type="entry name" value="NUCLEAR VALOSIN-CONTAINING PROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16725">
        <property type="entry name" value="Nucleolin_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="5">
        <location>
            <begin position="298"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="5">
        <location>
            <begin position="708"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="103"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="145"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="501"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="103"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="114"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="181"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="203"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="509"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="574"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="589"/>
            <end position="598"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAG5108706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="971" mass="106843" checksum="23C46E44D08CBC37" modified="2022-05-25" version="1">MNKMRKFNSSIDIIPLQGVSNEDIMSPMGNKSQMDDQMRLQRDPQIISRVQMYLYENEDKVYIDVNEMADSLQRKYRDYRAKKRSAFRALVRRAYDEITESFSKKSDSLSRQDEYDDEVEIESDTPGNDTLGRELIKMYKKSVDEMNGNGSDKELIDISSDDDSEKVEDIAPEKSQQFAMSSEQTSGKSGSKSSSSGSKAKLSKPEQAKKEDINHQKPAESSEVKSSGPDKSRKRPREKTADGSPSGILKKKKESQAPVETKIKFADIGGNKKVLEDVCRLLVHIKHPEIFKQLGMSPPRGFLLHGPPGCGKTLLAHAVAGELDIPLIKVAAPELVGGVSGESESRIRELFDRATATAPCVLFLDEVDAMAPHRATAQKEMERRMVAQLLSCLDDLGTKENGDKVLVIGATNRPESLDPALRRAGRFDREVSLGIPDKESRACILQVHAAKLSLANDVDIKTIASLTPGFVGADLVALLREAAIAAVDRVFKALKKETSAIHPMTSSDKSADKVPEKADSEEAEKSVDKPTEKEPEKSTTDEPTAETEQDSNKMTVSPDETQTETDKTNQSATPVEPEIIVPEEVNMASPGTSTDVTVPLTNGNTTEEQKAPEPLNSNFGDLDDLLQLLHDTNPLSPERLADLRIENIDFEVAYRSVQPSSKREGFATVPDVTWDDIGSLKEVREELQMAILAPVKHSDKFAAFGLMAPTGVLLCGPPGCGKTLLAKAIANEAEVNFISVKGPELLNMYVGESEKAVRQCFIRARNSAPCVIFFDELDALCPKRTEGDNSATSRVVNQVLTEMDGIEGRKGVYLMAATNRPDIIDPAVMRPGRFDKILYVGFPTPLDRVDILKAVTKNGTQPQFEDDVDLEAVGKSDKCDGYTGADLASLVREAGLEALKESTINNSDLTKVSMRHFDSAFTKIRPSVHEKEAKHYEKLQKLYGIKKQIVEPMETPVDTPMIDSSMEAMET</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MTC7</accession>
    <name>A0A8J2MTC7_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="22">Kainate 2 (Homo sapiens)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">HICCMSTLAB_LOCUS7260</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="14">Postsynaptic cell membrane</location>
            <topology evidence="14">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5093934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MTC7"/>
    <dbReference type="OrthoDB" id="5984008at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045211">
        <property type="term" value="C:postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015276">
        <property type="term" value="F:ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038023">
        <property type="term" value="F:signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.190.10:FF:000178">
        <property type="entry name" value="Glutamate receptor subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.190.10:FF:000061">
        <property type="entry name" value="Glutamate receptor, ionotropic kainate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000010">
        <property type="entry name" value="Putative glutamate receptor ionotropic kainate 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001828">
        <property type="entry name" value="ANF_lig-bd_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019594">
        <property type="entry name" value="Glu/Gly-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001508">
        <property type="entry name" value="Iono_Glu_rcpt_met"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015683">
        <property type="entry name" value="Ionotropic_Glu_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001320">
        <property type="entry name" value="Iontro_rcpt_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18966">
        <property type="entry name" value="IONOTROPIC GLUTAMATE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01094">
        <property type="entry name" value="ANF_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00060">
        <property type="entry name" value="Lig_chan"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10613">
        <property type="entry name" value="Lig_chan-Glu_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00177">
        <property type="entry name" value="NMDARECEPTOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00918">
        <property type="entry name" value="Lig_chan-Glu_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00079">
        <property type="entry name" value="PBPe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="Periplasmic binding protein-like I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="17" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="13" id="KW-0407">Ion channel</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="12" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="8 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0628">Postsynaptic cell membrane</keyword>
    <keyword evidence="9" id="KW-0675">Receptor</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0770">Synapse</keyword>
    <keyword evidence="4 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 19" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="514"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="590"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="772"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="domain" description="Ionotropic glutamate receptor C-terminal" evidence="20">
        <location>
            <begin position="381"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="domain" description="Ionotropic glutamate receptor L-glutamate and glycine-binding" evidence="21">
        <location>
            <begin position="391"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="833"/>
            <end position="862"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="834"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="469"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="474"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="640"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="641"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="691"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="site" description="Crucial to convey clamshell closure to channel opening" evidence="16">
        <location>
            <position position="619"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="17">
        <location>
            <begin position="54"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="17">
        <location>
            <begin position="703"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="22">
        <location>
            <position position="895"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00034104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR601508-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR601508-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR601508-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="SMART" id="SM00079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="SMART" id="SM00918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="CAG5093934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="895" mass="100551" checksum="E4EFB9DBC477613C" modified="2022-05-25" version="1" fragment="single">TGAIFHDGEEANLDAIQKALVIINNRDVPIFKLELKTKWINSSTDSFKTSLEACSLVAEGVAAIFGPGNPHTRNIVSSIASKFQIPHIEYSFRRMDDIKASHSTIRAYPDSDKISDALAKMMESMSWRQFTILYEKDDALSRLQKILWQHGPKDAPVTIRQLKPTYAKHSNEPNYRPLLKEVAKSSDFNVIIDAEPENLETIVKQMHEVKLLRDYYNYFITALHVPGDSMRTWLNKSEANVTTIQIIKQNQHDLLTVESAVLFDAVLLFGDALEVLQARLKINENFPLIIKPEPLSCDDPEVVYEAGYNLTKLMHELSSEGPTTGLMKFDENGGRTFNVSFHEFREEKANSSAEWIDGEFILKRSEEDRVKSAILDIEKKEFRVTTRVGAPWIIKVEDMTRGMQIDDGRYEGYAIDLITEMSEIMKFKFKFQFVPDKQFGVQDPDTKQWNGMIGQLLNREADLAVCDFTITKARESVVDFTMPFMNLGISILYLKPEDKKPELFAFLSPFSTDVWIYVVTAYLAVSVMFFIQARMSPNEWMNPHPCVSEPEELENSFSLKNSLWTTVGALMQQGSDIAPTAGSIRAIAGLWWFFVLIMVSSYTANLAAFLTAVKMGNTINNVEELAAQSKVKYGSQGKGSTAAFFSGSNVTTYQKMWETMMDAKPSVFVGSNDEGVDRVLKGKYLYAFLMESTAIEYNVLRDCNLMQVGSLLDNKGYGIALPPNSPYRTKLSLAILQLQEKGTLRALKTKWWERGSKNCSKSEPDGGGELTIAHVGGVFLVLIAGVSMSLICGIVEFLWNVRKVAVEEKITPKEALIAELKFAINISQDTKPVRISQSTSRSSRSQSSGSSSEKNRSTRASTARSFLRLDILDKVELNSRKDSTPASKSNNKLKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MV46</accession>
    <name>A0A8J2MV46_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transcription initiation factor TFIID subunit 12</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HICCMSTLAB_LOCUS10028</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TAF12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5100955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MV46"/>
    <dbReference type="OrthoDB" id="2193432at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017025">
        <property type="term" value="F:TBP-class protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051123">
        <property type="term" value="P:RNA polymerase II preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07981">
        <property type="entry name" value="HFD_TAF12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000011">
        <property type="entry name" value="Transcription initiation factor TFIID subunit 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037794">
        <property type="entry name" value="TAF12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003228">
        <property type="entry name" value="TFIID_TAF12_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12264">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12264:SF21">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03847">
        <property type="entry name" value="TFIID_20kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Transcription initiation factor TFIID subunit 12" evidence="8">
        <location>
            <begin position="31"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAG5100955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="134" mass="15430" checksum="F5FEBC6186A9F0CF" modified="2022-05-25" version="1">MADNSFDHAQTQNQEQGTKLSSSAELPQFLSKSKLQDLVREVDPTEQLEEEVEEMLLQLADDFVETTVNAACLLAKHRHANTVEVKDVQLHLERSWNMWIPGFGTDEVRPFKRATVTEAHKQRLALIRKNIKKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>S6D9J4</accession>
    <name>S6D9J4_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to cc_bv11.3_2.2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">bv11-3 (CcBV_2.2)</name>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS6050</name>
        <name evidence="4" type="ORF">HICCMSTLAB_LOCUS6105</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="Philos. Trans. R. Soc. Lond., B, Biol. Sci." volume="368" first="20130047" last="20130047">
            <title>Functional endogenous viral elements in the genome of the parasitoid wasp Cotesia congregata: insights into the evolutionary dynamics of bracoviruses.</title>
            <authorList>
                <person name="Bezier A."/>
                <person name="Louis F."/>
                <person name="Jancek S."/>
                <person name="Periquet G."/>
                <person name="Theze J."/>
                <person name="Gyapay G."/>
                <person name="Musset K."/>
                <person name="Lesobre J."/>
                <person name="Lenoble P."/>
                <person name="Dupuy C."/>
                <person name="Gundersen-Rindal D."/>
                <person name="Herniou E.A.Drezen.J.M."/>
            </authorList>
            <dbReference type="PubMed" id="23938757"/>
            <dbReference type="DOI" id="10.1098/rstb.2013.0047"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5092324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5092386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="HF586473">
        <property type="protein sequence ID" value="CCQ71155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S6D9J4"/>
    <dbReference type="OrthoDB" id="8147559at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036287030" evidence="2">
        <location>
            <begin position="21"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="231"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="273"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="231"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="280"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5092324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG5092386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCQ71155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="328" mass="36074" checksum="B9A2A2193EC4DDCF" modified="2016-04-13" version="1">MLLNSVVILFAVFGVPCIYAIPIDNDYDEILRELDEISEEIEQVYKLQGDIHGVVSIQAENTYSGNYKGKVHFGDILHQTNNKYSGDVTRDVQYGLNTIQSGNNYTANIDGEVQYGPDVQQHNNHYNTNVVGEVSFGATTRQSNNTYNGYLTGIINIGLSTNQTGNAYLGTITGNVSHGSTTSQINNTHLGTVEGKINHGALTNQAGNLYTEYVNGDVSLGSSTNQLNNTYENSESGEINYGSRTNQNNNDHRYDVNGIVYHGSRTVAYNNTFDNSQDGTVDHGSDTRQDNNSYEKSRANKNIFGSITDIQENKDLTTSESSTENIKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>S6D9M5</accession>
    <name>S6D9M5_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NF-kappa-B inhibitor alpha</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">I-kappa-B-alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">vank-1</name>
        <name evidence="8" type="ORF">HICCMSTLAB_LOCUS1420</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2013" name="Philos. Trans. R. Soc. Lond., B, Biol. Sci." volume="368" first="20130047" last="20130047">
            <title>Functional endogenous viral elements in the genome of the parasitoid wasp Cotesia congregata: insights into the evolutionary dynamics of bracoviruses.</title>
            <authorList>
                <person name="Bezier A."/>
                <person name="Louis F."/>
                <person name="Jancek S."/>
                <person name="Periquet G."/>
                <person name="Theze J."/>
                <person name="Gyapay G."/>
                <person name="Musset K."/>
                <person name="Lesobre J."/>
                <person name="Lenoble P."/>
                <person name="Dupuy C."/>
                <person name="Gundersen-Rindal D."/>
                <person name="Herniou E.A.Drezen.J.M."/>
            </authorList>
            <dbReference type="PubMed" id="23938757"/>
            <dbReference type="DOI" id="10.1098/rstb.2013.0047"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Inhibits the activity of dimeric NF-kappa-B/REL complexes by trapping REL (RELA/p65 and NFKB1/p50) dimers in the cytoplasm by masking their nuclear localization signals. On cellular stimulation by immune and pro-inflammatory responses, becomes phosphorylated promoting ubiquitination and degradation, enabling the dimeric RELA to translocate to the nucleus and activate transcription.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the NF-kappa-B inhibitor family.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001116">
        <property type="protein sequence ID" value="CAG5075266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="HF586477">
        <property type="protein sequence ID" value="CCQ71337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S6D9M5"/>
    <dbReference type="OrthoDB" id="20727at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051059">
        <property type="term" value="F:NF-kappaB binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071356">
        <property type="term" value="P:cellular response to tumor necrosis factor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034142">
        <property type="term" value="P:toll-like receptor 4 signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051070">
        <property type="entry name" value="NF-kappa-B_inhibitor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46680">
        <property type="entry name" value="NF-KAPPA-B INHIBITOR ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46680:SF1">
        <property type="entry name" value="NF-KAPPA-B INHIBITOR ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="7">
        <location>
            <begin position="54"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00041123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00041987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00045368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG5075266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCQ71337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="154" mass="17955" checksum="AE6E6EC1E0BCD0A9" modified="2016-04-13" version="1">MWPSENFIFPGEHSREGENILHYLCRNGGVVDLLNYKNAIIDENRYLVTEYNSQGQQCIHIVAREDKIDPRKKCRRLMEWGADINAKESINGDTPLHITVKTKNYELAEWLCRQPQVNIEALNYAQQTPYHLAYKCNDAKMMTILQETAAQRKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2E1K9</accession>
    <name>A0A8J2E1K9_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HICCMSTLAB_LOCUS865</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001114">
        <property type="protein sequence ID" value="CAG5074093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2E1K9"/>
    <dbReference type="OrthoDB" id="7679028at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052192">
        <property type="entry name" value="Insect_Ionotropic_Sensory_Rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42643">
        <property type="entry name" value="IONOTROPIC RECEPTOR 20A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42643:SF24">
        <property type="entry name" value="IONOTROPIC RECEPTOR 60A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="342"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="388"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="582"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAG5074093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="612" mass="71491" checksum="39FF78013E72E81D" modified="2022-05-25" version="1" fragment="single">DKRIKMWREIILCCLIAAIVGGNIIKMNGSREEGSSERLKRDARELVEMCLTNNSNPLVISKDLLPNDYNSAEAFNSWIIIDHKFNKQITGFFPAYPTYVLPFVSIDNLKPVIDNLQKSKFWNIKSPFVIVGTESRCLSAWRILKFMWDRDLLSVYYLCNKKNSTAIFTLNPYASYAPAPWKLVDKFSDNKKKISLFRLQFTKGPEICKIITFDKTDHLEDAEIKFLKSRDSLDISHPRKKKQTRIKKSNGITIFEVPTLINATSKIKFIPPPNYFDLLEQGYIEQLADNSCDIYAPIMPIEATDYNHVDVIAYYHEKSFSIATKKTNFLTVISDLTQNVRFVVGTIVLFVLFTILMFMINRDDLKLAVLDMVRLVVSMGLKTPLSRLVMKFVLFFGFLFAFLIVPDFQGNLSAILSDPLRRNIETLKDLYENKYDVYYYYGLENDIINEQLWITEEDQKYLKPITLGGMNDCVEFLIDNPKMACIFGTNSFLAAAYNEPELHVSKEPVFKKQLVHWVRKNWPLKDKFDKMMIKTRKPGFDSVIVNKRFFDGFFKKKLTLKKRSEESEDYEQFDFDNLIFNYYFIGFYTVFAFMVVVLEIILSRCFRSYRQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2E282</accession>
    <name>A0A8J2E282_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similar to Pank1: Pantothenate kinase 1 (Mus musculus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS1228</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001116">
        <property type="protein sequence ID" value="CAG5075044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2E282"/>
    <dbReference type="OrthoDB" id="275583at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004594">
        <property type="term" value="F:pantothenate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.510:FF:000004">
        <property type="entry name" value="Fbl, isoform B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.510">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004567">
        <property type="entry name" value="Type_II_PanK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12280:SF30">
        <property type="entry name" value="FUMBLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12280">
        <property type="entry name" value="PANTOTHENATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03630">
        <property type="entry name" value="Fumble"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5075044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="299" mass="32951" checksum="02B395F2837DC6A4" modified="2022-05-25" version="1" fragment="single">MMSPNKYKNNSNSSMASNGYSATSKQTKGFNPPPCESVNCMSMPWFGMDIGGTLCKLVYFEPKDITRDEADAEVETLKNIRRYLTKNSAYGKTGHRDTHLQMDNVEIRGRRGTLHFIRFPTSEMGNFLALAKSKGMANLVTTVCATGGGAFKFEDNFKREVNMSLAKFDELHSLIRGMLYIETTNPHECYYWADPTDDTLCHKVPFDFSEPYPFILVNIGSGVSILAVYGPDNFKRISGTSLGGGTFLGLCCLLTGCNTFEEAIELATGGDNTRVDKLVKDIYGGDYGPFCLPGDLVAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2E488</accession>
    <name>A0A8J2E488_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative kallikrein-13</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HICCMSTLAB_LOCUS21</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030000117">
        <property type="protein sequence ID" value="CAG5070432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2E488"/>
    <dbReference type="OrthoDB" id="10051896at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050430">
        <property type="entry name" value="Peptidase_S1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033116">
        <property type="entry name" value="TRYPSIN_SER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24276:SF91">
        <property type="entry name" value="AT26814P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24276">
        <property type="entry name" value="POLYSERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00135">
        <property type="entry name" value="TRYPSIN_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0720">Serine protease</keyword>
    <feature type="domain" description="Peptidase S1" evidence="5">
        <location>
            <begin position="21"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAG5070432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="108" mass="12192" checksum="3E48EFC2573EDDC3" modified="2022-05-25" version="1">MKIDDYVDITVFDFQKISKKLRVVAVKRVPYNLCRQMSLYSTVLIEDQHLCYGGQGFDSCQGDSGGPLADYDTVYGIASFGALECGHFPGVYESVSYYSDWIEYTIQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2ED71</accession>
    <name>A0A8J2ED71_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS1952</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001116">
        <property type="protein sequence ID" value="CAG5075968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2ED71"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5075968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="71" mass="8109" checksum="FC778A1C0308060B" modified="2022-05-25" version="1">MSLHSVSSRHENRLIAEIGYGSESRSALTLVIRTMEEITRTLTVFRANLVQNRYTENFIVCKMVATADTYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2EDS9</accession>
    <name>A0A8J2EDS9_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Similar to CtBP: C-terminal-binding protein (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HICCMSTLAB_LOCUS2217</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001117">
        <property type="protein sequence ID" value="CAG5076552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2EDS9"/>
    <dbReference type="OrthoDB" id="9991913at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140297">
        <property type="term" value="F:DNA-binding transcription factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001221">
        <property type="term" value="F:transcription coregulator binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05299">
        <property type="entry name" value="CtBP_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000012">
        <property type="entry name" value="C-terminal-binding protein 2 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043322">
        <property type="entry name" value="CtBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051638">
        <property type="entry name" value="CTBP_dehydrogenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029753">
        <property type="entry name" value="D-isomer_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029752">
        <property type="entry name" value="D-isomer_DH_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46029">
        <property type="entry name" value="C-TERMINAL-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46029:SF7">
        <property type="entry name" value="C-TERMINAL-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00065">
        <property type="entry name" value="D_2_HYDROXYACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00671">
        <property type="entry name" value="D_2_HYDROXYACID_DH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase catalytic" evidence="7">
        <location>
            <begin position="39"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding" evidence="8">
        <location>
            <begin position="135"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="389"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="403"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="442"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="465"/>
            <end position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAG5076552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="474" mass="50328" checksum="C5300F7AAC5588C1" modified="2022-05-25" version="1">MDKRKMLTKRPRMDTMRGPIANGPIQTRPLVALLDGRDCSIEMPILKDVATVAFCDAQSTSEIHEKVLNEAVGALMWHTIILTKEDLEKFKALRIIVRIGSGVDNIDVKAAGELGIAVCNVPGYGVEEVADTTLCLILNLYRRTYWLANMVREGKKFTGPEQVREAAQGCARIRGDTLGIVGLGRIGSAVALRAKAFGFIVMFYDPYLPDGIEKSLGLTRVYTLQDLLYQSDCVSLHCTLNEHNHHLINEFTIKQMRPGAFLVNTARGGLVDDDALAAALKQGRIRAAALDVHENEPYNVFQGQSNAQCPLKDAPNLLCTPHAAFYSDASCSELREMAASEIRRAIVGRIPDCLRNCVNKEYFHCSTGTYPESINGGYYAGALPIQQAHSTTPHDSAPPPPGGHSAVGVASSAGPNSSAGGGNAGPTGPAGPTVGGAGAGGPASAPPTAGLPGLPHSIVSEPDPRPSPPAPSPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2EHK9</accession>
    <name>A0A8J2EHK9_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS183</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030000985">
        <property type="protein sequence ID" value="CAG5072755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2EHK9"/>
    <dbReference type="OrthoDB" id="7551505at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5072755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="252" mass="28687" checksum="CA1F3ECE99C82F7B" modified="2022-05-25" version="1">MATKIKLTSSDEIHKFRSKMTCQLVGYVDAIESIKVNSKSVFKFVLNNGAGLRVQVYSWEEESPRTQKEVIMGHVIYLNSASCIPDSEYNTGNFHGAQIAIRPFTSIDNLGKFQKETHEASDIEPEIIQLIPLNALENSVLPWKFKICGYLKTKFTPVKVNDEINKAFFSITDGVYYLDATVNSYTADHGLEKGDKVELTGSMVYFRNDNCFLTVDSMDDIKIQEEPRKELIWLLNGITKIVLKNPFKRQKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2EID5</accession>
    <name>A0A8J2EID5_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to pol: RNA-directed DNA polymerase from mobile element jockey (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS431</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001114">
        <property type="protein sequence ID" value="CAG5073488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2EID5"/>
    <dbReference type="OrthoDB" id="7701141at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042575">
        <property type="term" value="C:DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09276">
        <property type="entry name" value="Rnase_HI_RT_non_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002156">
        <property type="entry name" value="RNaseH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33481:SF1">
        <property type="entry name" value="ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33481">
        <property type="entry name" value="REVERSE TRANSCRIPTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00075">
        <property type="entry name" value="RNase_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50879">
        <property type="entry name" value="RNASE_H_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="RNase H type-1" evidence="2">
        <location>
            <begin position="310"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5073488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="452" mass="50566" checksum="5B172111D7EE896C" modified="2022-05-25" version="1" fragment="single">MTQVNNPLSMAELEEVLSTCKNSSPGPNNLPLGFHENIIQYIQNFLKDRSIQVKVNDILSSKKEIANGVPQGSVLSVTLFLIAINDIVNCIPAPVQGLLYADDLIIYCSGSQVNNICDLLQEVLNNIVQWCSHSGFQLAENKTEYMVFSNMKKQTTCPHLHINNVLLKQTTHIKLLDMYFDSKLRSNVHIEHLKRKYHQKLSIIRTLASKNWGSDTDILLNVYKALIRSTLDYGAILYNTASKSLLKKLDTIQTSALRLSIGAFRSSPRPSILAEANEIPLDLRRTQLILNFKPSTTHIPPYPRDENNKKSFFSTIFTDASALNNLRGCSICFNDTTLKYRLPPEFSVFSSELIAISLSLNVIKNNQFKKTIICTDSLSSVQALMNPFSDSPMVQECQLKLWNLSKQGEIVIAWVPAHIGIPGNELADSEAKSAIIDGIDLTNISVPILKYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2EIH0</accession>
    <name>A0A8J2EIH0_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS491</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001114">
        <property type="protein sequence ID" value="CAG5073549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2EIH0"/>
    <dbReference type="OrthoDB" id="7989680at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47027">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47027:SF20">
        <property type="entry name" value="REVERSE TRANSCRIPTASE-LIKE PROTEIN WITH RNA-DIRECTED DNA POLYMERASE DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="395"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="396"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5073549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="416" mass="48848" checksum="52ED701BE2D8E38A" modified="2022-05-25" version="1">MIHGKSFIVWDGINISTSIFNILEGLQQGTVTSPILFIIFTSTILNKFGLNSGNNTYSGAYADDETVYVADSKIPVIQDKLTKIINEKYHCYKSWNLKMNPDKSETILFRKTVNEITPPTVLLIKNFQITITDNDTGEKFNIPNKDMVKYLGVHFDYLIRMNKHHAIQLKKGKNAFRANSRIFYDRNIQTKAKLICYQLLVRPIISYAAPIWWNVGPSVMEKYRKFERSCLKTCLGRYRSAESNYIKRLSNKEIYDLADIPRFDNFCLTLTRNYFSTMYEIGNDTIKNLKIDNNKLVNKMAGSNYSPPEIFTNLDRMGCIQNEFNVPIIYHIRRHCARKAIFTDMDNLQSESIVYSMALPARDHDSLDRLNEKYWWLHGEAKHLDELRRRARIKKQQFQQQQRVRPLLNSRRRHRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2EJ58</accession>
    <name>A0A8J2EJ58_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Similar to Gtpbp2: GTP-binding protein 2 (Mus musculus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HICCMSTLAB_LOCUS1107</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001116">
        <property type="protein sequence ID" value="CAG5074889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2EJ58"/>
    <dbReference type="OrthoDB" id="248233at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03708">
        <property type="entry name" value="GTPBP_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050055">
        <property type="entry name" value="EF-Tu_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009001">
        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43721">
        <property type="entry name" value="ELONGATION FACTOR TU-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43721:SF3">
        <property type="entry name" value="GTP-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50465">
        <property type="entry name" value="EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="6">
        <location>
            <begin position="86"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="18"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAG5074889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="507" mass="55747" checksum="1D777125CF7D13FC" modified="2022-05-25" version="1">MESFLALFDTEDVKSKKWDKYNGNTDVESMKTEDDLDLDCLPPEPEQVLRERSAGPQSKVSPPPERRVAEVIVKKLRKGDREGQDITDLRLAVVGSQDAGKSTLLGVLTQGELDNGRGRARLNMLRHLHEIRSGRTSSISHEIIGFAQDGHVLNYAEMTTAEEICEHASKVVTFIDLAGHRKYLRTTLLGLMGYSPHHVMLVVAPPLNEAAQEHMALCLALRLPFFIVVTKIDLGFSERLTLEQLEGAVRAQGCTMPLQVVKNTGNFRNERWEGKIPVFCVSSVSGVGLEDLTMFIRDLPAEPSDLETETGTCLFQIDETFKVAGLPDPVLGGLMVKGSIAPGSRLLVGPLPDGEFSHVRVVSLHRNKAPCCLVRASQSASLTLEGLEDALPHLRPGMVLVSSADQPHATVFFQATVFVVYHAKGIFPGFQATVHVGNVRQTCVMEGIMDVKEDGLQTNDTASVLFRFVSHPEYLHVGMRLLFREGKTKGIGKITQVFPLIGSQNRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2ELZ5</accession>
    <name>A0A8J2ELZ5_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cc_pif1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS304</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001114">
        <property type="protein sequence ID" value="CAG5073360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2ELZ5"/>
    <dbReference type="OrthoDB" id="7676957at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007784">
        <property type="entry name" value="PIR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05092">
        <property type="entry name" value="PIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035240256" evidence="1">
        <location>
            <begin position="23"/>
            <end position="589"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5073360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="589" mass="67392" checksum="94240F52F783F65F" modified="2022-05-25" version="1">MELIRLVLITMFVCLIITHINGVTPLPSANSISTSKQTSLKSELKKLKYKFTTEINVRSQSNDTIEITIEDPCNFEDVNKRVTCKLDDPNFCKLCPYTTCKHFDKEITIGTSIIPKNNEGEGYCVAFKDMSSGCNKHHGNWAMIKASSFKGNLNSNTYIRFCLCKRPGFIGNMTLFGNCEHPFICDGDVVNINVPYNDIECKCLNEFKSKIIGDNWHSCVPPSVGERVNWSTVPKPHNIAESFIPVKTYFDKMISYYVGNLDELIDPCSRCPVTGKPTYARSVTINTRGNSDATVICRPAESDEKNEPNWGIPLRRHTNTGSDGNMKRLLKGSWGPDVMLAIKWKELWVYDVAKHNKTDKSTQDCVFVFNYKDNEDFYLKLGLDKNYQYAINAGKDAFLGLTVLPMSTFTPTVLAECHRGGIIDYNPISLRYKCNILNENLACFLEQHEIKDFIINSKHNNISSTFLIRNYQQKRGLYIDDSSYWDAAQELGRAFGVALYEFNDESYQYLTYNPAIRSNQILKKNFPFVAMRVRPMSDKEMKNSHWKRHRISGIRHFVVDFVVTNDDKSSEGFLTEHHHHTADTNFVYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2GZG0</accession>
    <name>A0A8J2GZG0_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Similar to spop-b: Speckle-type POZ protein B (Xenopus laevis)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HICCMSTLAB_LOCUS494</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C48 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001114">
        <property type="protein sequence ID" value="CAG5073555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2GZG0"/>
    <dbReference type="OrthoDB" id="7624723at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008234">
        <property type="term" value="F:cysteine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.395.10">
        <property type="entry name" value="Adenoviral Proteinase, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003653">
        <property type="entry name" value="Peptidase_C48_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24413">
        <property type="entry name" value="SPECKLE-TYPE POZ PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02902">
        <property type="entry name" value="Peptidase_C48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50600">
        <property type="entry name" value="ULP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like protease family profile" evidence="6">
        <location>
            <begin position="75"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="5">
        <location>
            <begin position="413"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="566"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAG5073555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="594" mass="68144" checksum="D8E5786C3EBAA11A" modified="2022-05-25" version="1">MQSEEAWNRDKSKQAPRIPYQEGKRLKRAIDKSKVSALIFHNNGTIKNIDYYYHPNCPREYTVALTKSLNDDSILKLNGEDYNTLYNRGWLLNFTIDYCATALIKNSPEHSKTAYVICENSSKILKNSVENFNQNFYLNMKKQWSRKTHLFFPCHVQNSHWILVYVQLKEKWIYLLDSGQIKEDPEFYAANFKKFFSAVFPSKNKKDDWLLKNMVYPSQDEKDGFNCGIYVIYFIEQILKGTARPNSGSIFVVDSVFSAPEPKNLFKFSHSFLYLMGKSGLQKSPEFATPKIPGIKFKINTQINIDTKTIDVTIKKDDPRKSVSIITLKIGETTRTRRSVDWTKKVFFKSISLPITSDVHPVSHDIFGAPSADGPKYTVTVDCSIIWGGFVEDFYYPDVSTVLKILHNNEEFNDIVIKVEKTEFKAQKNIIAAQSPVFYKMLTSDMKESKENSITFPDIEPDVIEELLLFFYKGKMDKAEKDAEFAIKLFEFAHMYEIKRVISTCEYILITKLTKGNVFKIHNKGQLYKSVILQQHAITFIEMNVTEIRNDVALELPTSLGCTGSTFGSTSTTSEILPQSPQFGTDDPDDADGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H3L0</accession>
    <name>A0A8J2H3L0_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Quinone] (Drosophila pseudoobscura pseudoobscura)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HICCMSTLAB_LOCUS1297</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001116">
        <property type="protein sequence ID" value="CAG5075142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H3L0"/>
    <dbReference type="OrthoDB" id="269227at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF216">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE OXIDOREDUCTASE N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00624">
        <property type="entry name" value="GMC_OXRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035314534" evidence="4">
        <location>
            <begin position="16"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="5">
        <location>
            <begin position="307"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="568"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="611"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="270"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAG5075142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="634" mass="70645" checksum="CF9D65D218ECEBD5" modified="2022-05-25" version="1">MAAIIYCLLIGITSASGPLSYMTNILKYYQQYPPFPGLLNKEPSLLNNYDFIIIGAGSGGSVLANRLSEVPHWKILLLEAGRDEIFLTDIPLLAAAMQLTPYNWGYRTEPNSEFCRSMTEGRCNWPRGKAVGGTSVINFMIHSRGLPRDYDQWAALGNRRWRYRDVAQYFAKSERFVDSMGHNRLNSSVYGQDGFLDVTSVPWRSKLRDRFLKAGQELGYNLKDCNDATPTGFCPVAVNLRHGRRLSAAKAYLRPVRNRPNLHVSRNSQVTRVIIDENSKVARGVEFVKDGRRMKVMATKEVLLAAGSLNSPQILMLSGVGPKNHLENLRIEVLADLPVGRNLQDHVSMAALTFLVNDTVSIVESRIATNFKDTFDYLAYGQGPFTAPSGAEALAFVNTKSGEGRYSKKNNLSLDVTNEAESSKIEEPDIELVFGIGSMAGDLSGTLRSIFSLPDSWYREVFGDFIGRDGFSIVPILLHPKSRGSVTLQSKNPFDAPIFNPNYFENEEDLKTLVRGIKKALEIAETEAFKKYNATLLPVKFPGCKNIDSGTDEYWECVCRQISTTLGHFVGTCKMAPKEQDGVVNDELKVYGIERLRVVDASVIPNLISGHTNAPTYMIGEKASDMIKEEWLNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H5I6</accession>
    <name>A0A8J2H5I6_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS875</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001114">
        <property type="protein sequence ID" value="CAG5074103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H5I6"/>
    <dbReference type="OrthoDB" id="7700219at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5074103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="296" mass="34846" checksum="383161BE2E99E676" modified="2022-05-25" version="1">MRDRIYLMNTVVGAAALYGVEVWGWGGVKDIERVQGRFCKMALGVNRNTPGYIWRTEAGVQNIKATTRERAARYVKDVLAMEEDRWPKIALREEMRGILNRNPAKWGRKLHAAIKEMGCEEIAGMIYNKEEKEKIDEKINAGVERYKEKLKEDDEKAIERSSYNKMYKKIMIEKDGYNYWKDDKKRGEDKEQWARIRCGNIGRAYKKGYTEWTNLNTSNKVQRDKKGVNEKERKYMEKWDKLVEEEEIESEICKILKGEIDVNFCEIFRKVEKSIRSKTEAEKIGEESAEVEQRTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H633</accession>
    <name>A0A8J2H633_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similar to SLC16A9: Monocarboxylate transporter 9 (Gallus gallus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS2588</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001117">
        <property type="protein sequence ID" value="CAG5077907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H633"/>
    <dbReference type="OrthoDB" id="6499973at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008028">
        <property type="term" value="F:monocarboxylic acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF309">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER 7-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="113"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="138"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="171"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="196"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="414"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="449"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="480"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="512"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="560"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="594"/>
            <end position="616"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5077907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="641" mass="70723" checksum="FDC945D4BD6269FE" modified="2022-05-25" version="1">MSDCDKPSAEDRKNSKITSKEVTNYFSDQNEELTLEDLAPDGGWGWMIALAMIIVFVTTFCAGASFAIVFGAFFEEKGQSGSAMTLLNSVFMISFSISGVVTNALLKKYSLRLVSVTAALLFAIPNIWSAFVTHVYELAVIFFIQGIGAGLMNTISSASFNAFFVKKRAKVMSAAQVIIGLGGIVYPMIIEKMMDIYGFRGTAAIIGALSLNAIAGMMMMHPVEWHLRDPNEVLEERRQLKGPQPQSEHNHSALNKVKILGSSDRRSTIHCTQDFMEPARWSSLCNIKDNPGCQEPLLFINSKTVEAISMDLDPDMRPRSKSISMKMQLARSLSLLPASSIGNITGALVEAQHRRDLTTKASLDELKELNTPIGDSINGHNKSDHHDENKNLVIKRKQQLSDLFELSLLKDRTFVIMSLGISFVFVSDFTFISLVPLAMMHDGYTNSQAAVTITVAAAAELASRILYLIFTLIVNCRAKFVFFFAMIVMGFAKLGTKFTLNCQGTSLGFQVLIIYFTAFLYFGNTLMGIYICTAGIGIVRTFMMVPQPLVVVENYPVEMYAACYGIFTLVNGIVMVVIGPLVGIIKDVTNSFEVAQLVLVGLNCAFIVPWALEFLVDFRQKRRNRVVNTTGNINADNHVIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H6R9</accession>
    <name>A0A8J2H6R9_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS3004</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001117">
        <property type="protein sequence ID" value="CAG5079410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H6R9"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5079410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="108" mass="11722" checksum="8501C52C66BE27A3" modified="2022-05-25" version="1">MAFAQYSSNNRTGLAACFGNYYQWGFQSAKLSAWYPPLPSTSKPQRPLGVQQIAPGVQLLPPPPPPPASAQVHKNARSPLESIERIGRGVVETSEAGFKKEGGLRHSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H767</accession>
    <name>A0A8J2H767_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similar to Clvs1: Clavesin-1 (Rattus norvegicus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS3146</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5080938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H767"/>
    <dbReference type="OrthoDB" id="1434354at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902936">
        <property type="term" value="F:phosphatidylinositol bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1200">
        <property type="entry name" value="Alpha-tocopherol transfer"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.20">
        <property type="entry name" value="N-terminal domain of phosphatidylinositol transfer protein sec14p"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011074">
        <property type="entry name" value="CRAL/TRIO_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036273">
        <property type="entry name" value="CRAL/TRIO_N_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10174">
        <property type="entry name" value="ALPHA-TOCOPHEROL TRANSFER PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10174:SF166">
        <property type="entry name" value="LD40136P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00650">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00180">
        <property type="entry name" value="CRETINALDHBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM01100">
        <property type="entry name" value="CRAL_TRIO_N"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00516">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46938">
        <property type="entry name" value="CRAL/TRIO N-terminal domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRAL-TRIO" evidence="1">
        <location>
            <begin position="101"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="CRAL-TRIO" evidence="1">
        <location>
            <begin position="395"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="domain" description="CRAL-TRIO" evidence="1">
        <location>
            <begin position="732"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="domain" description="CRAL-TRIO" evidence="1">
        <location>
            <begin position="959"/>
            <end position="1123"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5080938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="1174" mass="136596" checksum="874B575B0A22BD27" modified="2022-05-25" version="1">MGMGNEFDYKCGLSEDLQTVAFEELREDENVRSQALEQFRSWILKHPSIKHCRTDPIFLLRFLRTKKFSLPMAQEMLERYLTIRQLYSDWFQNLDINDPDMEAIIDNGYIVPLLEKDEQGRQVILTCAGRFDPYKYTSAQMVRAHSLVSEVLMDDEENQVRGYTHVNDESGLTMGHVSAFSLTDIRNLLRWIQSSTPMRHKQTHFINIPNYATKVIDFALSLLNDKLRARIMVHTSMEDLKEAINPKILPKEYGGSVPLADMIAVFKKKLREKRDEIKALDDMYIEVSPKDTCSSVSDGLCGISDYKCTLSKETQAIALAELREDENMRNQSLEQFRAWILKHPSIKHCRTDPEFLLRFLRTNKFSLLMAQDMLKRYLQARQLSSDWFQNLDIDDPAVEAIIDSGFIFPLPEKDQYGRRVIMSCIGQFDPHKYTGSQMMRAQTLAFEAVIGDEENQVRGYTYVYDFSGLTMSHLSLFSLTEIRKVVNWIQNGIPMQQKMAYLFNVPKNATKVIDFSMSLLNDKFKDSIAVYKNMEKLKKVIDPKILPKEYGGDVPIADMIAAFKKKLREKREELKALDDMHIEISPEERKSLLTDISEGMVVQSEINYKCTLSKETQKIALEELREDENIRNQALEQFRDWILKHPSIKRCRTDPGFLLRFLRTKKFSLPIAQSMLERYLHARQLSSEWFQNLDINDPVMEAIIDNGYVVPLLEKDQYGRTVVLTRNVHTLAFETLISDEENQVRGYAYIYDNAGVTMSHVSMLSFTEIRNILSWVQNGIPMRHKMSILVNVPNYAIKVIEFCVSLFTNKHRERITICTDVEELKKKFDPKILPKEYGGDVPLADMVAAFKEKLREKREELIALDDMYIEVSQKNTKENQAIALAELREDENIRNQSLEQFRAWILKHPSIKRCRTDSLFLLRFLRTKKFSLPMAQDMLVRYLQAKQLYPEWFKNLNLDDPIMQGIIDSGFVIPSLEKDKQGRQVLFSFHNRIDPSLYGSKEITRLFALTFEMFMDDEENQVRGYKHVAEASGVSLAHMTAWSLTDIRILFRWLQNSTPMRHREMCFIGMPSFAFKVFEFVLSLMSEKLRSRTSIFKNIKDFKKTIDPKILPKEYGGTVPLADMLAVYKEKLRKKNEEIKALDDMYIEISPKEKSLISDNFGGVSGSFRKLEID</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H793</accession>
    <name>A0A8J2H793_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Similar to Mtnr1a: Melatonin receptor type 1A (Mus musculus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HICCMSTLAB_LOCUS3278</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5081408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H793"/>
    <dbReference type="OrthoDB" id="5984709at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24228">
        <property type="entry name" value="B2 BRADYKININ RECEPTOR/ANGIOTENSIN II RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24228:SF59">
        <property type="entry name" value="NEUROPEPTIDE RECEPTOR 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 12" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="72"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="129"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="169"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="210"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="259"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="292"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="11">
        <location>
            <begin position="70"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAG5081408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="379" mass="41753" checksum="71548F344D239E8D" modified="2022-05-25" version="1">MNVTAMRSITTLASLMTGDDSDRMTMTVSSTTLVGMLAGIDVKISMDRSKTNIFDSDLDVSPVTLSSDWSRVARLLLLASLAVVGSVGNAFLVNVALADLLVTGLVIPSSAIVILAGHEDSLSICRFEWTLEALCFLVTILTLATIAGENYARLCLPTEKYEALTPSRVTATIFVIWVIAGIAVGLQSSLDFGPDFCGRKFIPVVIPQVIGAFFLVLLPALLTPILYLRLVLRVRRAVRGSFKPPASFSWDYELMKTNIYSFTLFAIFWLPFGAAILASAQRRVGARIFYNLAWFALSKSCINSLVYCVFDRHFRNAYVKLFHYCCCKTTVSFSRRPRGDGSRSSGDVRLRVHIIHSYASPASCRPNVARPNGRDVYEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H7S6</accession>
    <name>A0A8J2H7S6_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Methyltransferase HEMK2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">HemK methyltransferase family member 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Lysine N-methyltransferase 9</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Methylarsonite methyltransferase N6AMT1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">Methyltransferase N6AMT1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Protein N(5)-glutamine methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">HICCMSTLAB_LOCUS3498</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Methyltransferase that can methylate proteins and, to a lower extent, arsenic. Catalytic subunit of a heterodimer with TRMT112, which monomethylates 'Lys-12' of histone H4 (H4K12me1), a modification present at the promoters of numerous genes encoding cell cycle regulators. Catalytic subunit of a heterodimer with TRMT112, which catalyzes N5-methylation of Glu residue of proteins with a Gly-Gln-Xaa-Xaa-Xaa-Arg motif. Methylates ETF1 on 'Gln-185'; ETF1 needs to be complexed to ERF3 in its GTP-bound form to be efficiently methylated. May also play a role in the modulation of arsenic-induced toxicity by mediating the conversion of monomethylarsonous acid (3+) into the less toxic dimethylarsonic acid. It however only plays a limited role in arsenic metabolism compared with AS3MT.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-lysyl-[histone] + S-adenosyl-L-methionine = N(6)-methyl-L-lysyl-[histone] + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10024"/>
            <dbReference type="Rhea" id="RHEA-COMP:9845"/>
            <dbReference type="Rhea" id="RHEA-COMP:9846"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61929"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:10025"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>methylarsonous acid + S-adenosyl-L-methionine = dimethylarsinate + S-adenosyl-L-homocysteine + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:11684"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16223"/>
            <dbReference type="ChEBI" id="CHEBI:17826"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="10">Heterodimer; heterodimerization with TRMT112 is required for S-adenosyl-L-methionine-binding.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic/archaeal PrmC-related family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5082238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H7S6"/>
    <dbReference type="OrthoDB" id="406152at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035657">
        <property type="term" value="C:eRF1 methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036009">
        <property type="term" value="F:protein-glutamine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000077">
        <property type="entry name" value="HemK methyltransferase family member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052190">
        <property type="entry name" value="Euk-Arch_PrmC-MTase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004557">
        <property type="entry name" value="PrmC-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007848">
        <property type="entry name" value="Small_mtfrase_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00537">
        <property type="entry name" value="hemK_rel_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45875">
        <property type="entry name" value="METHYLTRANSFERASE N6AMT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45875:SF1">
        <property type="entry name" value="METHYLTRANSFERASE N6AMT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05175">
        <property type="entry name" value="MTS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 18" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase small" evidence="17">
        <location>
            <begin position="33"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00050903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00053180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00062344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00075330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00076540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00080992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00083337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00093624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00093667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF05175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="CAG5082238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="214" mass="23807" checksum="B904387E29A81CE2" modified="2022-05-25" version="1">METAITDLNNFEDVYEPSEDSFLLIDSLESDLSELKKLKPSICLEIGSGSGVVINSLALACKNKWPGFFIAVDINPSACRATKNTSFINNNNSNYLDVIQMDLVTALRMLSQFDVVIFNPPYVPTETSEIGDSNLITRAWAGGNKGREVMDQLFPFIPKLLAPGGLFYCVTVKENDISDIIELFRGMKMQGQVISDRKVRGEHLHILRFVKPAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H848</accession>
    <name>A0A8J2H848_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS3346</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5081658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H848"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="9"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5081658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="136" mass="14930" checksum="CB5E758862E7CB2A" modified="2022-05-25" version="1">MSGKNRNMSPLEESSPRSSETEIPDNMLPREIRIGGQNKRKRDGSFRKLAGSPIEDQSQNQNDNDDDENDSSNNNNDVAFVLEESGELRDDVRMSGGIGIEETHLALGRPNYADRFLRGNCPGPEGSPVTLGVLTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H8B4</accession>
    <name>A0A8J2H8B4_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS4008</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5084082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H8B4"/>
    <dbReference type="OrthoDB" id="6769862at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5084082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="69" mass="7792" checksum="2A8F8552818F9F7C" modified="2022-05-25" version="1" fragment="single">MMAMKLKSLIGLNPLDRPLLIIPKFNNINLCVASTLEHYLTVTSTIINNNDCLFLTIKKPYKKASKDTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H8K7</accession>
    <name>A0A8J2H8K7_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Similar to ninaC: Neither inactivation nor afterpotential protein C (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HICCMSTLAB_LOCUS4262</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell projection</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5085050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H8K7"/>
    <dbReference type="OrthoDB" id="6108017at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042995">
        <property type="term" value="C:cell projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016459">
        <property type="term" value="C:myosin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000146">
        <property type="term" value="F:microfilament motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030832">
        <property type="term" value="P:regulation of actin filament length"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.720">
        <property type="entry name" value="Myosin VI head, motor domain, U50 subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052409">
        <property type="entry name" value="Myosin-III_kinase_activity"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001609">
        <property type="entry name" value="Myosin_head_motor_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46256">
        <property type="entry name" value="AGAP011099-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46256:SF2">
        <property type="entry name" value="NEITHER INACTIVATION NOR AFTERPOTENTIAL PROTEIN C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00063">
        <property type="entry name" value="Myosin_head"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00242">
        <property type="entry name" value="MYSc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51456">
        <property type="entry name" value="MYOSIN_MOTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0966">Cell projection</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-0505">Motor protein</keyword>
    <keyword evidence="7 11" id="KW-0518">Myosin</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Myosin motor" evidence="12">
        <location>
            <begin position="1"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAG5085050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="283" mass="32992" checksum="EE4F7E13AAAAE9B5" modified="2022-05-25" version="1">MCLQNKLTVAGALGFSTSTNTMYVQNAMLQPLTVQSDRDLNFIVGHRSNFGILYYFYDAMEARGKLQDFKLPPERKLRYLRDGISGYSNRCASDKRNNHRENINIFEKIDEIMILMEFNDAAESIWKILSAILLIGEISFIINTDNEADVDDMKLSSFVAELLGLDQKKFVWSLTNYCLIRNGEAIRHKYSCEEALLARDILACTLYQRLVDWIINFINLKLSVTRTLFGSKYLISILDFFGFECFTYNKVEQLIVNTVNEQLQCYYNQRVFISEMVRYLYLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H8L3</accession>
    <name>A0A8J2H8L3_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to Zyg11b: Protein zyg-11 homolog B (Mus musculus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS4207</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5084820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H8L3"/>
    <dbReference type="OrthoDB" id="5783533at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031462">
        <property type="term" value="C:Cul2-RING ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055142">
        <property type="entry name" value="ZER1-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051341">
        <property type="entry name" value="Zyg-11_UBL_adapter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12904">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12904:SF22">
        <property type="entry name" value="ZYG-11 FAMILY MEMBER B, CELL CYCLE REGULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22964">
        <property type="entry name" value="ZER1-like_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Protein zer-1 homolog-like C-terminal" evidence="2">
        <location>
            <begin position="420"/>
            <end position="497"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5084820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="528" mass="59966" checksum="943013C738A654E3" modified="2022-05-25" version="1">MFESPRSLQEVCVDFICDNVLALCEFHSSNSGRTNFNPILTASSEEEPFIENTTDDNSLAVTTSSIASSVNDINFCSLTRLNFKDPDIFLPTQISEQLLASLCEKKALSDLTITLFDSKTTILRHVRLKDASRLSVKGLKVLKQHKIIDLEVNGLRITINDLIGCLGQWSLNNLRSLSVVKGSFIDCSRVCVFMALSKLRALHTLNVSGTEFNKHGLEIIVEDLPLLESLDISDTRVDDITPLKRCKNRLKSLAMYKLRITGYGNLKTVFSELDSLRNLDISDEQDSNSFEMFAPIRSKITDLLRAVNCMPYLTRLDISGKDEIEVKDLKEFLKNHPHLEFLGLVHSNICYEDSLINPANKDYRPGLIVSGMATEAQILEALRRYPHRPTYVQKCLYNLFRLTPHFSEPRVDVIKLVIPGMRAHPEEFKVQMAATACLYNLTKGELATKIHPFILKQIVDLTLTAMESYPNHYQLQKNTLLTLCSDRILQDVPDQDEDHQNLLGELNEQCNLYSLPVQLQKYDWHTVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H904</accession>
    <name>A0A8J2H904_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similar to ida-1: Receptor-type tyrosine-protein phosphatase-like ida-1 (Caenorhabditis elegans)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS4496</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5087370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H904"/>
    <dbReference type="OrthoDB" id="9880441at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030141">
        <property type="term" value="C:secretory granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051046">
        <property type="term" value="P:regulation of secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033522">
        <property type="entry name" value="IA-2/IA-2_beta"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46106">
        <property type="entry name" value="IA-2 PROTEIN TYROSINE PHOSPHATASE, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46106:SF4">
        <property type="entry name" value="IA-2 PROTEIN TYROSINE PHOSPHATASE, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0675">Receptor</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035286744" evidence="1">
        <location>
            <begin position="29"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5087370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="181" mass="21044" checksum="4DBDE64752A0A004" modified="2022-05-25" version="1">MGRKKWWKGGSSLLLLIFIFINNQVVHSDGEIGCLFDRNVCTSIDEICFDDAAFGRCISSTDDSDESTYQYDLDPRQLELLRKQLEKLVAEKYEWSHPYTQCVMQEALYSIHNDDTLPLAVVNFMPTRGHGYGNFANEMYHPPLLSPLDEQYPQNTEDYPYLVIEDQKPEHHLTLNFENNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H9J7</accession>
    <name>A0A8J2H9J7_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Odorant receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HICCMSTLAB_LOCUS3525</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cell membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the insect chemoreceptor superfamily. Heteromeric odorant receptor channel (TC 1.A.69) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5082318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H9J7"/>
    <dbReference type="OrthoDB" id="7696577at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005549">
        <property type="term" value="F:odorant binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004984">
        <property type="term" value="F:olfactory receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004117">
        <property type="entry name" value="7tm6_olfct_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21137">
        <property type="entry name" value="ODORANT RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21137:SF42">
        <property type="entry name" value="ODORANT RECEPTOR 83A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02949">
        <property type="entry name" value="7tm_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 9" id="KW-0552">Olfaction</keyword>
    <keyword evidence="7 9 10" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="8 9" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="126"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="178"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="268"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="295"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU351113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAG5082318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="391" mass="45614" checksum="8E29365B1FDF9B83" modified="2022-05-25" version="1">MNLFDDLYWRATRIHLSVIGAWPFQSYITSIIIRTVVCFLFESLYISEVIKLVEVWGDLKLTLECIPILVLHSITQVKILNVHVNLNKMKNLLLRIKSDWESGLLDESEIEFLRNDGRKHKDFMSLYFIILYSSTISYELMPLIPVALDIILPLNESRARIFLYQAEYFVEPEKNLTFIYIHSYIVSPLIAITFIGTDSLYSAFIQHACSMFTIIGRRLQNLRADESTNKKHKFFKTNRHVKDIIICIKMHKNVLEFVRLLEEHYTNYLLVILGILVLGLSAIGFRVFLIDGIEGRVQCISYFFGHVAHLFFLSYFGQRLINFSEYVHESICRAELYKFSSDMKPMIILLMMRSKLVSKITAGKLYIMSLENFTTVAKTSFSYFTVLTSFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H9K2</accession>
    <name>A0A8J2H9K2_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similar to Pbdc1: Protein PBDC1 (Mus musculus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS4571</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5087666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H9K2"/>
    <dbReference type="OrthoDB" id="10248897at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3560.10">
        <property type="entry name" value="yst0336 like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023139">
        <property type="entry name" value="PBDC1-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008476">
        <property type="entry name" value="PBDC1_metazoa/fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021148">
        <property type="entry name" value="Polysacc_synth_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13410">
        <property type="entry name" value="PROTEIN PBDC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13410:SF9">
        <property type="entry name" value="PROTEIN PBDC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04669">
        <property type="entry name" value="PBDC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Polysaccharide biosynthesis" evidence="1">
        <location>
            <begin position="32"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5087666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="168" mass="19283" checksum="A08196D9269AE2EA" modified="2022-05-25" version="1">MAQIGSVSADQLMAGSSVLSRPAEEFENDATVEAMWAMKAFEHAEIYFNILCSVDPKLLKLTPHDDLIYKSFREVFPSLSIAKLSEDEMKSPEGKNKWRPFCEQFKDIIEDYSMGTLLRADCTDEYSEQNSILVSRIQFYAIELARNREGLNDLIRQKFKPKKLTKNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HA30</accession>
    <name>A0A8J2HA30_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Similar to Myophilin (Echinococcus granulosus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HICCMSTLAB_LOCUS4953</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the calponin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5088716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HA30"/>
    <dbReference type="OrthoDB" id="21595at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015629">
        <property type="term" value="C:actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031032">
        <property type="term" value="P:actomyosin structure organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd21207">
        <property type="entry name" value="CH_dMP20-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050606">
        <property type="entry name" value="Calponin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001997">
        <property type="entry name" value="Calponin/LIMCH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000557">
        <property type="entry name" value="Calponin_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003096">
        <property type="entry name" value="SM22_calponin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47385">
        <property type="entry name" value="CALPONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47385:SF22">
        <property type="entry name" value="GH21596P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00402">
        <property type="entry name" value="Calponin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00889">
        <property type="entry name" value="CALPONIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00888">
        <property type="entry name" value="SM22CALPONIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00033">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51122">
        <property type="entry name" value="CALPONIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="3" id="KW-0112">Calmodulin-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="6">
        <location>
            <begin position="4"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAG5088716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="167" mass="18880" checksum="9541C850B62A0A36" modified="2022-05-25" version="1" fragment="single">ARNKEQEAEVLEWIEAVLGEKLPKGDYEDILKDGVILCQLINKLAPGSVKKIQTKGTNFQLMENVQRFQAAIKNYGVPQEEIFQTADLFERRNIPQVTLCLYSLGRMTQKHPEYNGPRLGPKMAEKNERTFTEDQLRASEGQLNLQMGFNKGASQSGHGGFGNTRHM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HAV0</accession>
    <name>A0A8J2HAV0_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS5421</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5089899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HAV0"/>
    <dbReference type="OrthoDB" id="10403730at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5089899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="233" mass="25605" checksum="088B7F50E2EDA533" modified="2022-05-25" version="1">MRHDGAVIINHGQMQRVVQPVGIQEHIAAARPADVVPGNMVPVAVRAVPARVFENLEIEEPVNMNRDDGEAGYMNPGVEEPVNINPGEGEPVNMNRDDGEAGDMNPGDEEPVNINPENAEADDMNFGGEEADDMNPGDEPVARQPVALNHSRARRLINKINRDSSSSTAHGLICTIRFNEALSYIIKSCHHASIGKQCALQLLKNFVEKREAFLLCPYCRARVTSIDILYFTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HB59</accession>
    <name>A0A8J2HB59_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Similar to Srm: Spermidine synthase (Mus musculus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HICCMSTLAB_LOCUS6021</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the spermidine/spermine synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5092294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HB59"/>
    <dbReference type="OrthoDB" id="38125at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004766">
        <property type="term" value="F:spermidine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008295">
        <property type="term" value="P:spermidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000013">
        <property type="entry name" value="Spermidine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.140.10">
        <property type="entry name" value="Spermidine synthase, tetramerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00198">
        <property type="entry name" value="Spermidine_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030374">
        <property type="entry name" value="PABS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030373">
        <property type="entry name" value="PABS_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001045">
        <property type="entry name" value="Spermi_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037163">
        <property type="entry name" value="Spermidine_synt_N_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00417">
        <property type="entry name" value="speE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11558:SF11">
        <property type="entry name" value="SPERMIDINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11558">
        <property type="entry name" value="SPERMIDINE/SPERMINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01564">
        <property type="entry name" value="Spermine_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01330">
        <property type="entry name" value="PABS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51006">
        <property type="entry name" value="PABS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0620">Polyamine biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PABS" evidence="5">
        <location>
            <begin position="1"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAG5092294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="273" mass="30474" checksum="AF2E1DFF0EA512F1" modified="2022-05-25" version="1">MDAFKKGWFSEFNDLWPGISVSFEVTKILHHEKSQFQDILLVDTDEFSYQEMISFLPLCSHPNPKNVLIVGGGDGGVAREVVKHPGVEHVTQVEIDGRVLELSRQYLPSLACGLSHPKVTLYVGDGFEFMKKHSQQFDVIITDSSDPIGPAESLFQESYFALMKTALKPGGLVCSQAGTIWSNDMQVEKTLGHCKSVFPAASYAWTSVPTYPTGQIGFVMGSLDPNTKFGEPVKVFSEKELDEMKLKYYDDKIHRSSFVLPRFAAKVIKNLIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HBE9</accession>
    <name>A0A8J2HBE9_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">leucine--tRNA ligase</fullName>
            <ecNumber evidence="3">6.1.1.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Leucyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">HICCMSTLAB_LOCUS5906</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>tRNA(Leu) + L-leucine + ATP = L-leucyl-tRNA(Leu) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:11688"/>
            <dbReference type="Rhea" id="RHEA-COMP:9613"/>
            <dbReference type="Rhea" id="RHEA-COMP:9622"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57427"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78494"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.4"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.4" evidence="3"/>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5092087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HBE9"/>
    <dbReference type="OrthoDB" id="15954at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004823">
        <property type="term" value="F:leucine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006429">
        <property type="term" value="P:leucyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00812">
        <property type="entry name" value="LeuRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000060">
        <property type="entry name" value="Leucine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000100">
        <property type="entry name" value="probable leucine--tRNA ligase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.730.10">
        <property type="entry name" value="Isoleucyl-tRNA Synthetase, Domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002300">
        <property type="entry name" value="aa-tRNA-synth_Ia"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002302">
        <property type="entry name" value="Leu-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013155">
        <property type="entry name" value="M/V/L/I-tRNA-synth_anticd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009008">
        <property type="entry name" value="Val/Leu/Ile-tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43740:SF2">
        <property type="entry name" value="LEUCINE--TRNA LIGASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43740">
        <property type="entry name" value="LEUCYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08264">
        <property type="entry name" value="Anticodon_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00133">
        <property type="entry name" value="tRNA-synt_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00985">
        <property type="entry name" value="TRNASYNTHLEU"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50677">
        <property type="entry name" value="ValRS/IleRS/LeuRS editing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 11" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 11" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-tRNA synthetase class Ia" evidence="12">
        <location>
            <begin position="47"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="Aminoacyl-tRNA synthetase class Ia" evidence="12">
        <location>
            <begin position="361"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="domain" description="Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding" evidence="13">
        <location>
            <begin position="645"/>
            <end position="749"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU363035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF08264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CAG5092087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="825" mass="95083" checksum="553B8FA6204A34C1" modified="2022-05-25" version="1">MKYRLTNLKLSKKLNQPFINNVRHASASLGLWESNMTNEIRHKIEAHWKDKILSEKSEPSTGEKYYVLSMFPYPSGSLHMGHVRVYAISDAVSRFHRLKGRDVIHPMGWDAFGLPAENAALERKIDPQEWTESNISNMKAQLKTLGCDFDWDCELATCHPEYYRWTQELFLKLFDRGLAYQKQSFVNWDPVDETVLADEQVDQNGNSWRSGAKVQKKLLKQWFIRTTAFAKFLMSGLDDPMLKEWRDIIKIQKHWIGECTGTSLDFKLITDLPGKPESFNVWTDRPEFIDQAKFVAVSKDNFLAKAKIKNFDDQDLETVFLDATVVNPFNNEELPLQQKRQQAMQKAREWKIGGYEVSPTLRDWLISRQRYWGTPIPIIHCKSCGTVPVPREQLPVTLPKKLTSDKGIPNLRQAVDWLKTSCPKCGTEAFREADTMDTFVDSSWYFMRYIDVKNTSEMFSKEKAKKFLPVDLYIGGKEHAALHLYYARFVNHFLHSEGLLPTREPFKQLLVQGMVMGKSFRVKGSGKYLKSEQVEKVGKNFVEKETKLPVVVTWEKMSKSKYNGVDPMEMFREYGADTTRLIMLADVAPTSTFQGIFNWQQRLWLTIRQFLKRRENISLEEVANTPTKEEFIKDDAYLCNSRNYYVKGVTFNIIGSQQLSVAISKMQGLTNSIRKVSLNCLTHSPEYEKTLGTQIIMLAPIAPRFASELWSGFCSAKYFLAEDFFMRDKDVLQQKWPVVDSDFELDLDVVVNGMQVDLLKIKKSILDQLTAEAAADLALQSPGAKKHIKNREILGFKYYYEQNCDGKVSFKVAIKPASVKVETSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HBR1</accession>
    <name>A0A8J2HBR1_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS4349</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5085341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HBR1"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035176558" evidence="2">
        <location>
            <begin position="18"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="101"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="217"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="111"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="265"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5085341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="274" mass="30633" checksum="8BB5E67AD99F1AD7" modified="2022-05-25" version="1">MASATTLAILMALAANAVFLDASLQEPSSADTLEYKLAPDSSIEESVQPEAHKSNSTRHSVHPQPSMRRLQDRLPTAPHHNINNHTLPRFYSNNTVHKNSLNSTSFSPLQPTSLMSTTMGPPTTTTRPRYPRPEPLPSPFNHYIPAPPQQPPFNCYCPGPVSYPMYYNYYPPQYPFFPTYPKSGQRPAPYNNMPSSGPFNQFPTRPSGFYDRLERPSLPEFNNQNTGAPKDPLNMFDEPSTTTEAPGYGFQLKTVSRNRTEEGSSSHYSSSSSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HCA6</accession>
    <name>A0A8J2HCA6_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS6680</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5093231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HCA6"/>
    <dbReference type="OrthoDB" id="7553975at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5093231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="99" mass="11158" checksum="D43BCBCA24FF1268" modified="2022-05-25" version="1">MNRKKQLPGSAFSGSTETGPKTDPKKMNSSDTLTDQSDRSNELKNLITFESSHLSVWQVFHIIMAIVLRFNLSDEVWQAILDLIKLAAGPKFKYLDTSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HCJ3</accession>
    <name>A0A8J2HCJ3_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">protein-tyrosine-phosphatase</fullName>
            <ecNumber evidence="3">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">HICCMSTLAB_LOCUS7281</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10684"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="EC" id="3.1.3.48"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein-tyrosine phosphatase family. Receptor class 2A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="3"/>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5093955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10253954at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009653">
        <property type="term" value="P:anatomical structure morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048666">
        <property type="term" value="P:neuron development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="CDD" id="cd14553">
        <property type="entry name" value="R-PTPc-LAR-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000028">
        <property type="entry name" value="Neuronal cell adhesion molecule"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000010">
        <property type="entry name" value="receptor-type tyrosine-protein phosphatase delta isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000027">
        <property type="entry name" value="receptor-type tyrosine-protein phosphatase delta isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.10:FF:000002">
        <property type="entry name" value="receptor-type tyrosine-protein phosphatase delta isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.10:FF:000001">
        <property type="entry name" value="Receptor-type tyrosine-protein phosphatase F isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:001111">
        <property type="entry name" value="tyrosine-protein phosphatase Lar isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:001197">
        <property type="entry name" value="tyrosine-protein phosphatase Lar isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:001000">
        <property type="entry name" value="tyrosine-protein phosphatase Lar isoform X3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:001130">
        <property type="entry name" value="tyrosine-protein phosphatase Lar isoform X3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:001015">
        <property type="entry name" value="tyrosine-protein phosphatase Lar isoform X4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000242">
        <property type="entry name" value="PTP_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050713">
        <property type="entry name" value="RTP_Phos/Ushers"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46957">
        <property type="entry name" value="CYTOKINE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46957:SF6">
        <property type="entry name" value="PROTEIN-TYROSINE-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00102">
        <property type="entry name" value="Y_phosphatase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00700">
        <property type="entry name" value="PRTYPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00194">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50055">
        <property type="entry name" value="TYR_PHOSPHATASE_PTP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="10 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="12" id="KW-0675">Receptor</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="1251"/>
            <end position="1274"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="20">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="20">
        <location>
            <begin position="94"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="21">
        <location>
            <begin position="185"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="21">
        <location>
            <begin position="288"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="21">
        <location>
            <begin position="386"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="21">
        <location>
            <begin position="482"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="21">
        <location>
            <begin position="580"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="21">
        <location>
            <begin position="686"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="21">
        <location>
            <begin position="782"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="21">
        <location>
            <begin position="879"/>
            <end position="973"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="21">
        <location>
            <begin position="975"/>
            <end position="1077"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="18">
        <location>
            <begin position="1346"/>
            <end position="1601"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="19">
        <location>
            <begin position="1521"/>
            <end position="1592"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="18">
        <location>
            <begin position="1632"/>
            <end position="1887"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="19">
        <location>
            <begin position="1809"/>
            <end position="1882"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="272"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1215"/>
            <end position="1246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="272"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00051722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="CAG5093955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="1896" mass="214161" checksum="5273F17563E26420" modified="2022-05-25" version="1">MWAYCRVSGFKNIAAGVGCILWLADWLRGCTLNPNRATPRWLVVPRREGKGGALQIEESEVDDQGQYECVANNTVGTEYSEAIQLYVRVRRLPPSFSIPPPSVSEVMMGASLNLTCVAVGSPMPYVKWRKEPSTEMTPEDKLPIGKNVLYLTEIKESANYTCIAASDLGLIEASSMVKVQSLPGAPENVQVSEITATSVKLTWSYKRPDELQYYVIQHKPKNANQAFAETSGITTMYYHVRSLSPYTDYELYVIAVNVIGRGPRSHPVYVTTGETTESTNGGSRPGSAPRKVQVRPLSSSTMVIQWDEPETPNGQVTGYKVYYTTDPNQPMASWQSRVVDNNQLTTVSDLTPHTMYTIRVQALTSVGPGPLSQPIQIKTQQGVPSQPENLSVVDVGENSVTLQWSKPAHSAENILSYELYWNDTYAQEKHHRRIGVTENYTLTGLYPNTLYYVWLAARSQRGEGATTVPYEVRTKQYVPGAPPRNITGHAISTTAIKVSWKPPPTESSNGRIAYYKLQVVETGRSDSEARVIKLNSTEFVLDELKKWTAYRIWVVAGTSVGDGPPSYPITVKTDEDVPGNPQDVTATALNSTTIRVEWKPPRVNDQNGVIRGYHVHIQEVAEEGKDLLNEPIRQDVHEEGVHAINVTNLQPDTKYYVQVAALTRKGDGDRSLPVHVRTPGGVPNRPQVNVKVINQDPIVLELEWAKPSEPAGQLTGYRVKYGIKNQTLKEEFIKDINQVTFKIKDVERGVHYEFRVAGENQNGVGQETVRYYESPEGEPSGPPTNLTYSFQTQDTVCVKWSEPARRHRNGQIIRYDVEFHKKNDHSTIEARNTTQERAVFTNLEEATEYVFHVRAHTVRGSGPYSEKITIVTEKDIGRAPLNVKAVATSESNVEVWWEPVPNRDKIIGYKIFYTMTAVEDLDQWKQKLIGMTESAELENLERDTAYAIAVAARYKNDVLGRLSQKVTVKVKPEDVPLNLRASDTSTHSMTLSWTPPIRLNPTGYQVSFDAVKEFVDSQGITQTQIVPRRTIRLDATATTTTIDELQPFTTYNVNVSAVPADSSYKPPAKITVTTQMAAPKPMVKPDFYGVVKKEEIHVILPQASEEYGPIAYYYLIVVPEDKATAHKQPDEFTEDVITGKNAKQDPENAPYIAAKFSHRTIPYTFQLGSGDVYEGFENKKLDPTKRYRIFVRAIVDTPKKHLYTSSPFSEYLSLDMREVPPGDPPSRPNPDISPDGNPEVSVTNSGQEPGMVWVIGPIIAALMVSICLVLLFVIRKRRQPCKAPDQAAVTRPLMAADISSNHAPSDPVEMRRLNFQTPGMMSHPPIPISELGNHIDRLKANDNLKFSQEYESIEPGQQFTWDHSNMEVNTSKNRYANVIAYDHSRVILQTTDGIPGSDYINANYCDGYRKQNAYVATQGPLQNTFADFWRMCWELRTSTIVMMTKLEERTRIKCDQYWPTRGAETYGQMTVTISDIQELATYCIRTFQVCRNGYTDRREIKQLQFTAWPDHGVPEHPAPFLQFLRRVKTLNVPDSGPLVVHCSAGVGRTGCFIVIDSMLERIKHEKMIDIYGHVTCLRAQRNYMVQTEDQYIFIHDALFEAVICGFTEVPARNLHSHIQKLMQTELDNTTGMELEFKKLSNIKADSTRFISANLACNKHKNRLVHILPYECTRVCLQPQRNMEGSDYINASFIDGYRYRGAYIATQGPLNETTDDFWRMLWEHNSTIVVMLTKLKEIGREKCHQYWPSDRSIRYQCFVVDPIAEYNMPQYILREFKVTDARDGASRTVRQFQFIDWPEQGVPKSGDGFIDFIGQVHKTKEQFGQDGPITVHCSAGVGRTGVFITLSIVLERMQYEGVVDIFQTVRILRTQRPAMDQYQFCYRASLEYLGSFDHYAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HCV1</accession>
    <name>A0A8J2HCV1_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS5478</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5090070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HCV1"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5090070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="95" mass="11299" checksum="7DB7C155E5E1EE58" modified="2022-05-25" version="1">MAAGFYVCKRNKEVVSGSELRNFRVQCDTEVEVMKNMYAGMIKYRLEKAGQRRILFNQVEDILYEIFSRYLPATFIHGMFFYFSNFELSKLVEIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HD62</accession>
    <name>A0A8J2HD62_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cilia- and flagella-associated protein 91</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HICCMSTLAB_LOCUS7056</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Cilium axoneme</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the CFAP91 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5093730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HD62"/>
    <dbReference type="OrthoDB" id="567787at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005930">
        <property type="term" value="C:axoneme"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026720">
        <property type="entry name" value="CFAP91"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032840">
        <property type="entry name" value="CFAP91_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22455">
        <property type="entry name" value="CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 91"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22455:SF10">
        <property type="entry name" value="CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 91"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14738">
        <property type="entry name" value="CFAP91"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0966">Cell projection</keyword>
    <keyword evidence="9" id="KW-0969">Cilium</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="9" id="KW-0282">Flagellum</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CFAP91" evidence="8">
        <location>
            <begin position="24"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="161"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00029468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF14738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAG5093730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="284" mass="33718" checksum="5712B740C2E5CF48" modified="2022-05-25" version="1">MPNVRVFDYDSRVMTARNLLSKGTQTDYRDSETQTIPWEPPYKLALGSKEPEVLGLENLSWGSGLPVGTDELKIIKRMRVKKSWESLLPPLDCKVNVQTHKAIITMIDRDEWSFRDKELEMMMDERLEWINKVIKTNNYQRKKKIIQRFEKVGKYLTQLRNKRINEIKHELNREIRKISAKNRNKNSKFIKNPGGKTTDLKDECLFRFKLDDESFYDSLLNRKTLQDKKDPMSYLTRVNHINQLSDKKTDELCLRETRWTDDMLKNLHIDLKNIRLNTASKLIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HDG8</accession>
    <name>A0A8J2HDG8_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="4">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">HICCMSTLAB_LOCUS7468</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="4"/>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5094956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HDG8"/>
    <dbReference type="OrthoDB" id="2122982at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007219">
        <property type="term" value="P:Notch signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd02339">
        <property type="entry name" value="ZZ_Mind_bomb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000090">
        <property type="entry name" value="E3 ubiquitin-protein ligase MIB1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.20:FF:000259">
        <property type="entry name" value="E3 ubiquitin-protein ligase mind-bomb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.90:FF:000005">
        <property type="entry name" value="Putative E3 ubiquitin-protein ligase mib1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000054">
        <property type="entry name" value="Putative e3 ubiquitin-protein ligase mind-bomb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042056">
        <property type="entry name" value="MIB1/2_ZZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010606">
        <property type="entry name" value="Mib_Herc2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037252">
        <property type="entry name" value="Mib_Herc2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040847">
        <property type="entry name" value="SH3_15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000433">
        <property type="entry name" value="Znf_ZZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043145">
        <property type="entry name" value="Znf_ZZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24202:SF53">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE MIB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24202">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE MIB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06701">
        <property type="entry name" value="MIB_HERC2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18346">
        <property type="entry name" value="SH3_15"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00569">
        <property type="entry name" value="ZZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00291">
        <property type="entry name" value="ZnF_ZZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159034">
        <property type="entry name" value="Mib/herc2 domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51416">
        <property type="entry name" value="MIB_HERC2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01357">
        <property type="entry name" value="ZF_ZZ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50135">
        <property type="entry name" value="ZF_ZZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="13" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="10" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="11" id="KW-0862">Zinc</keyword>
    <keyword evidence="9 14" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MIB/HERC2" evidence="16">
        <location>
            <begin position="11"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="ZZ-type" evidence="15">
        <location>
            <begin position="85"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="MIB/HERC2" evidence="16">
        <location>
            <begin position="120"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="13">
        <location>
            <begin position="439"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="13">
        <location>
            <begin position="472"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="13">
        <location>
            <begin position="505"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="13">
        <location>
            <begin position="538"/>
            <end position="570"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CAG5094956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="586" mass="63872" checksum="10EE4B86627ABE00" modified="2022-05-25" version="1">MEASTSSGTRTTRFMMEGVGARVIRGPEWKWGKQDGGEGHVGTVRNFESPEEVVVVWDNGTAANYRCSGAFDLRILDSATTGVKHDGTMCDTCRQQPIFGIRWKCAECGNYDLCSICYHGDKHHLRHRFYRITTPGVDWQWEDQDGGNGRRGKVNEIQDWSAASPRSAAYVIWDNGAKNLYRVGFEGMADLKVVNDAKGQTVYRDHLPLLGEQGPGRPGPHGLQIGDQVNVDLELEIVQSLQHGHGSWTDGMFECLGTTGTVVSIDEDHDIVVSYPSGNRWTFNPAVLSKVQTPVSAGTSTATENQAFAVGDLVQICNDLEKIKLLQRGHGEWAEAMAPTLGKIGRVQQIYHDGDLKVEVCCTSWTYNPQAVVKVASSDRSMPGNNSGERLSALLKKLFETHVSGDVNEELVKSAANGDAVQSEECLKRLDADVNGVFSGHTALQAASHNGHLDVIKILLRYKADVEIEDKDGDRAVHHAAFGDEPGVMALVAGAGADLNARNKRRQTALHIAVNKGHAGVVRTLLELGCHPSLQDAEGDTPLHDAISKKRDDMLTLLLDHAADITRTNNTGFNALHHAALRGNPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HDH5</accession>
    <name>A0A8J2HDH5_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Cullin-1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HICCMSTLAB_LOCUS5887</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8 9">Belongs to the cullin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5092061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HDH5"/>
    <dbReference type="OrthoDB" id="27073at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043066">
        <property type="term" value="P:negative regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902532">
        <property type="term" value="P:negative regulation of intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070936">
        <property type="term" value="P:protein K48-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010564">
        <property type="term" value="P:regulation of cell cycle process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031146">
        <property type="term" value="P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000014">
        <property type="entry name" value="Cullin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000161">
        <property type="entry name" value="Cullin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1310.10:FF:000007">
        <property type="entry name" value="Cullin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1310.10:FF:000011">
        <property type="entry name" value="Cullin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1310.10:FF:000019">
        <property type="entry name" value="Cullin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1310.10:FF:000023">
        <property type="entry name" value="cullin-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1310.10">
        <property type="entry name" value="Cullin Repeats"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1030.10">
        <property type="entry name" value="Ring Box Chain A, domain 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045093">
        <property type="entry name" value="Cullin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059120">
        <property type="entry name" value="Cullin-like_AB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016157">
        <property type="entry name" value="Cullin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016158">
        <property type="entry name" value="Cullin_homology"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036317">
        <property type="entry name" value="Cullin_homology_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001373">
        <property type="entry name" value="Cullin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019559">
        <property type="entry name" value="Cullin_neddylation_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016159">
        <property type="entry name" value="Cullin_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11932">
        <property type="entry name" value="CULLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00888">
        <property type="entry name" value="Cullin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26557">
        <property type="entry name" value="Cullin_AB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10557">
        <property type="entry name" value="Cullin_Nedd8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00182">
        <property type="entry name" value="CULLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00884">
        <property type="entry name" value="Cullin_Nedd8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75632">
        <property type="entry name" value="Cullin homology domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74788">
        <property type="entry name" value="Cullin repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01256">
        <property type="entry name" value="CULLIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50069">
        <property type="entry name" value="CULLIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="3" id="KW-0488">Methylation</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Cullin family profile" evidence="10">
        <location>
            <begin position="386"/>
            <end position="582"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00069612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAG5092061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="710" mass="81962" checksum="D971A80DA7D08CCF" modified="2022-05-25" version="1">MSSHRGSGGSHQGGPPGLKQIDLDQIWGDLREGIEQVYNRQCMSKPRYIELYTHVYNYCTSVHQQVSKTSTKVKKGHASGGAQLVGLELYKRLRDFLRNYLISLLKHGIDLMDEDVLQFYTRQWEEYQFSSKVLNGVCAYLNRHWVRRECEEGRKGIYEIYQLALVTWRDNLFKHLNRQLGLNEEDPSAKGQNLTVYKDSFENVFLEDTERFYTRESVEFLRQNPVTEYMKKAEQRLSEEQKRVQVYLHQTTNERLAKTCERVLIEKHLDIFHAEFQNLLDSDKNPDLGRMYLLVARIPNGLGELRNLLECHIANQGLAAIDKCGDTAANDPKIYVNTILEVHKKYNALVLVAFNNDSGFVAALDKACGRFINSNSVTRAANSSSKSPELLAKYCDLLLKKSSKNPEEAELEDTLNQVMVVFKYIEDKDVFQKFYSKMLAKRLVQHMSASDDAEASMISKLKQACGFEYTSKLQRMFQDIGVSKDLNEAFKRHLTNSAEPLDIDFSIQVLSSGGRKLNWLYNMSKGELHTNCFKNRYTLQASTFQMAVLLQYNAATSWTIQQLHDATQIKMDFLLQVIQILLKAKLLTAPVDDEAELTPLSSVELFTGYKNKKLRVNINIPMKTELKIEQETTHKHIEEDRKLLIQAAIVRIMKMRKVLKHQQLVAEVLNQLSSRFKPRVHVIKKCIDILIEKEYLERTEGQKDTYSYLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HE57</accession>
    <name>A0A8J2HE57_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">mitogen-activated protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HICCMSTLAB_LOCUS8002</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.24" evidence="3"/>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5096023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HE57"/>
    <dbReference type="OrthoDB" id="192887at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004707">
        <property type="term" value="F:MAP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071243">
        <property type="term" value="P:cellular response to arsenic-containing substance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071276">
        <property type="term" value="P:cellular response to cadmium ion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034614">
        <property type="term" value="P:cellular response to reactive oxygen species"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042742">
        <property type="term" value="P:defense response to bacterium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050832">
        <property type="term" value="P:defense response to fungus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008340">
        <property type="term" value="P:determination of adult lifespan"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003007">
        <property type="term" value="P:heart morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006955">
        <property type="term" value="P:immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038001">
        <property type="term" value="P:paracrine signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045793">
        <property type="term" value="P:positive regulation of cell size"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048082">
        <property type="term" value="P:regulation of adult chitin-containing cuticle pigmentation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900407">
        <property type="term" value="P:regulation of cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031347">
        <property type="term" value="P:regulation of defense response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050776">
        <property type="term" value="P:regulation of immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009408">
        <property type="term" value="P:response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042542">
        <property type="term" value="P:response to hydrogen peroxide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006970">
        <property type="term" value="P:response to osmotic stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042594">
        <property type="term" value="P:response to starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd07851">
        <property type="entry name" value="STKc_p38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000063">
        <property type="entry name" value="Mitogen-activated protein kinase 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000769">
        <property type="entry name" value="Mitogen-activated protein kinase 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003527">
        <property type="entry name" value="MAP_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050117">
        <property type="entry name" value="MAPK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008352">
        <property type="entry name" value="MAPK_HOG-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24055">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01773">
        <property type="entry name" value="P38MAPKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01351">
        <property type="entry name" value="MAPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="7 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="20"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="49"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAG5096023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="379" mass="43251" checksum="C027C5C54A24E993" modified="2022-05-25" version="1">MPKFHKVEINKTEWEVPERYQMLTPVGSGAYGQVSAVDTVSNQKVAIKKLARPFQSAVHAKRTYRELRMLKHMNHENVIGLLDVFHPSTSLEDFQQLYLVTHLMGADLNNIVRTQKLSDDHVQFLVYQILRGLKYIHSAGIIHRDLKPSNIAVNEDCELKILDFGLARPTENEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDQIYQEFCSGALATADIHQLNLIMEVLGTPRDEFMLKISSESAKNYIQSLPPLKKKNFKEVFRGANPLAINLLELMLELDAEKRITAEQALAHPYLAQYADPTDEPLSLPYDQSFEDMELPVEKWKELIYHEAVNFVPQQLPSTSAAADSSSMKNIIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HEB7</accession>
    <name>A0A8J2HEB7_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 14">NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">HICCMSTLAB_LOCUS8370</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. Involved in the interferon/all-trans-retinoic acid (IFN/RA) induced cell death. This apoptotic activity is inhibited by interaction with viral IRF1. Prevents the transactivation of STAT3 target genes. May play a role in CARD15-mediated innate mucosal responses and serve to regulate intestinal epithelial cell responses to microbes.</text>
    </comment>
    <comment type="function">
        <text evidence="14">Complex I functions in the transfer of electrons from NADH to the respiratory chain. Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Complex I is composed of 45 different subunits. Interacts with CARD15, but not with CARD4. Interacts with STAT3, but not with STAT1, STAT2 and STAT5A. Interacts with OLFM4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Mitochondrion inner membrane</location>
            <topology evidence="1 14">Single-pass membrane protein</topology>
            <orientation evidence="1 14">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the complex I NDUFA13 subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5096757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HEB7"/>
    <dbReference type="OrthoDB" id="3308at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045271">
        <property type="term" value="C:respiratory chain complex I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009346">
        <property type="entry name" value="GRIM-19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12966:SF0">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12966">
        <property type="entry name" value="NADH DEHYDROGENASE UBIQUINONE 1 ALPHA SUBCOMPLEX SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06212">
        <property type="entry name" value="GRIM-19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 14" id="KW-0249">Electron transport</keyword>
    <keyword evidence="11 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="10 14" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7 14" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 14" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="6 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 14" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="70"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00045908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00046797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU368034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CAG5096757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="123" mass="14107" checksum="ED1BAB8B44EF611F" modified="2022-05-25" version="1">MKCQQFFKLVAALEDVVDVWKLYMYICIYIVQSNLDLIKMSTTKNFYTQDLPPKGGYNPIQTSRVALRRILTPAVASGLTIATTVVGGIGYFFNYRYARRDQVELRSAKLAIMPMLLAERDRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HEV5</accession>
    <name>A0A8J2HEV5_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS8704</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5097431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HEV5"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5097431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="129" mass="14795" checksum="AE7A3E90FB81A3BD" modified="2022-05-25" version="1" fragment="single">EKERKNRYEGMRLKNGISVSSMSLYIIVKGIFNYEGSRTYCHSVEGLDIALQSSFNDNFHLMGSFDLMRSGELPHHLSEYQKPMCEVLNFFAKNGYRVISSTYAKAALRPNKNGLPEDGMIWTLEKKMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HF38</accession>
    <name>A0A8J2HF38_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Similar to rasp: Protein-cysteine N-palmitoyltransferase Rasp (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HICCMSTLAB_LOCUS8558</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the membrane-bound acyltransferase family. HHAT subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5097133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HF38"/>
    <dbReference type="OrthoDB" id="420606at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016409">
        <property type="term" value="F:palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051085">
        <property type="entry name" value="MB_O-acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004299">
        <property type="entry name" value="MBOAT_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13285">
        <property type="entry name" value="ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13285:SF18">
        <property type="entry name" value="PROTEIN-CYSTEINE N-PALMITOYLTRANSFERASE RASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03062">
        <property type="entry name" value="MBOAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="65"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="195"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="228"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="379"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="463"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="501"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="622"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="650"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="684"/>
            <end position="704"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAG5097133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="721" mass="85052" checksum="855EEE3893959468" modified="2022-05-25" version="1">MEDNPSLHKVEVGFYFATCVCGILYSTYQLYLAGSFFDYFDDIHDDFSTGWSWIGRKKDVSDHEWAAMVPFLRIFIPWILCCWYITISLAFLWTYIGVPGVIFMLIQPCIVCLLISIKNLPLIYFAELGLVFLYHYKPLMSLVRKDWLQLDSNWDYLLTISTFWVQLRSTSCAIDNVKIYRHNSLQGFLKNFIETTAYCLYFPTLFMGPFILYEDFHKGINRHNKWTLGRLVITALNLLRFSFWILFTEISAHFLYVTAFKYQPQAIEKFNSWAFFGFGYWMGQYMCNKYVVLYGLAGEFARADDINAPPPPKYISTRHGSYDDFAIGWSWIKKRQDISDGEWWSFIPLIKKLVPWIAVQLLISHFIKYKKFNSTPSVVCLLIAIRNLPLIYFVELGTLYLYQYDPLMNLVWNDWLQVDQEWQYLLTVTIFWIQLRSISCSVDNVTRYQHKNLSSFFKNFIEITAYCLYLPTMFTGPFFLYSDFRKSFSGSEKWTVHRLGVTVFNLLRYTFWLLVTELMMHFLYTSALKSYPERVGAFNAWAFYGFGYSMGQYFCNKYIVVYGLAGEFSRADDIDAPPPPKCIGRVHLYSEMWKHFDRGLYQFLVKYIYGPIAQYNFPLKKFFASFLTFSFIYIWHGLAQYVFIWSLLNFIGITIESIARYIGTSSVYNYYLNKYLSPKNARRFHCLIASPLLSMSAISNFYFFGGMAIGNLFTFRFFQGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HF49</accession>
    <name>A0A8J2HF49_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS6916</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5093567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HF49"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5093567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="134" mass="15431" checksum="723B8F67EF51BE54" modified="2022-05-25" version="1">MTLRRVATYPGQHLCLESVKRIPPLRKKKKTHTHTHTTYTDIRTSPRKHSGRLSRTSKRQHPLKTRFSKNGRKRYKMDPELNPTTAGNSPMYQAIEEDKLEDLILLLKNGMDVNEPIITTGEFAGFTALHMLHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HGA5</accession>
    <name>A0A8J2HGA5_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Similar to Rab2a: Ras-related protein Rab-2A (Mus musculus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">HICCMSTLAB_LOCUS7327</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Endomembrane system</location>
            <topology evidence="12">Lipid-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5094001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HGA5"/>
    <dbReference type="OrthoDB" id="9989112at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01866">
        <property type="entry name" value="Rab2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000275">
        <property type="entry name" value="Putative ras-related protein Rab-2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050209">
        <property type="entry name" value="Rab_GTPases_membrane_traffic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47979">
        <property type="entry name" value="DRAB11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="10" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0636">Prenylation</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="189"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="13">
        <location>
            <begin position="198"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00037868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CAG5094001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="214" mass="23612" checksum="F4B1C8750E782025" modified="2022-05-25" version="1">MAYAYLFKYIIIGDTGVGKSCLLLQFTDKRFQPVHDLTIGVEFGARMITIDGKQIKLQIWDTAGQEAFRSITRSYYRGAAGALLVYDITRRETFNHLTTWLEDARQHSNSNMVIMLIGNKSDLDARREVRREEGEAFAREHGLVFMETSAKTAANVEEAFINTAKEIYEKIQEGVFDINNEANGIKIGPQHSPTNPGGLSGTGGQGNAPGGGCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HGF6</accession>
    <name>A0A8J2HGF6_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Similar to wun: Putative phosphatidate phosphatase (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HICCMSTLAB_LOCUS6963</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PA-phosphatase related phosphoesterase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5093627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HGF6"/>
    <dbReference type="OrthoDB" id="8907274at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008195">
        <property type="term" value="F:phosphatidate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046839">
        <property type="term" value="P:phospholipid dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006644">
        <property type="term" value="P:phospholipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.144.10">
        <property type="entry name" value="Phosphatidic acid phosphatase type 2/haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043216">
        <property type="entry name" value="PAP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000326">
        <property type="entry name" value="PAP2/HPO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="PAP2/HPO_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10165:SF197">
        <property type="entry name" value="FI04477P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10165">
        <property type="entry name" value="LIPID PHOSPHATE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01569">
        <property type="entry name" value="PAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00014">
        <property type="entry name" value="acidPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="Acid phosphatase/Vanadium-dependent haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="60"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="188"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="216"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="294"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphatidic acid phosphatase type 2/haloperoxidase" evidence="7">
        <location>
            <begin position="108"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG5093627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="432" mass="49436" checksum="DB477F876C20E1DE" modified="2022-05-25" version="1">MDRSSKLLLVKIIIDFTCVAIVGFTVLGFYLFGQPYQRGFFCNDESLMHPYRESTVTNTMLYIVGIFLPICVILCGEFLYAKNTSGQSSVVLFGRVIPRWVVLAYHKIGSFAFGAVANVLTTDVAKYAIGRLRPHFIELCKPSINCSLPINHHKFIEHDQFTCTASNVTKRLLKELYLQLRITWKGSVIFKHFVQLILILLAWATAMSRVSDYKHHWSDVLVGMLIGVIVSLITERRESGITNAGHGDKSRAMEYDAETAMQDESRPLKNLETSYGGIQITQQHIMIIFRNVRIINVLILLCTLVLFIVFTLKIKEVYFMYQKNSRYHEYKQDLEKLSLDFEKAEKRANKSADYVRKISEVIIKYERDLKNTTASISEDSEHCQMIENDGRLDVIRTYHSGGSVDRLILPTDLKTRSHITGSFGVELMSQDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HGI5</accession>
    <name>A0A8J2HGI5_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS7465</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5094950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HGI5"/>
    <dbReference type="OrthoDB" id="7646940at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5094950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="164" mass="19588" checksum="C3655B0847F2F91F" modified="2022-05-25" version="1">MTKKQNIEKILTTYFYWNKKMAEKVNPKDKTCDCKGWCIAKKDNPEKGIFQSITNIVYVFRTIKRIDLKISRLKLRIERKYGNVEDQKKKLKVYMSSRESYLQYVHGIIYKLDSCRFVREHLQGTELGDKYLKIKQENSTLYDKDYFVKNELPNDLGERPIGIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HGW0</accession>
    <name>A0A8J2HGW0_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Similar to ROS1: Proto-oncogene tyrosine-protein kinase ROS (Gallus gallus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HICCMSTLAB_LOCUS7310</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5093984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="65481at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:002572">
        <property type="entry name" value="Tyrosine-protein kinase receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057329">
        <property type="entry name" value="Beta-prop_Rol-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000033">
        <property type="entry name" value="LDLR_classB_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050713">
        <property type="entry name" value="RTP_Phos/Ushers"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46957">
        <property type="entry name" value="CYTOKINE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46957:SF3">
        <property type="entry name" value="CYTOKINE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25494">
        <property type="entry name" value="Beta-prop_Rol-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00135">
        <property type="entry name" value="LY"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63825">
        <property type="entry name" value="YWTD domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1899"/>
            <end position="1924"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="3">
        <location>
            <begin position="93"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="3">
        <location>
            <begin position="201"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="3">
        <location>
            <begin position="579"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="3">
        <location>
            <begin position="1074"/>
            <end position="1177"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="3">
        <location>
            <begin position="1581"/>
            <end position="1685"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="3">
        <location>
            <begin position="1786"/>
            <end position="1888"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2046"/>
            <end position="2066"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2115"/>
            <end position="2199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="2057"/>
            <end position="2066"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="2119"/>
            <end position="2136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="2144"/>
            <end position="2159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="2160"/>
            <end position="2172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="2177"/>
            <end position="2199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG5093984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="2199" mass="247337" checksum="E7D4151CAF48A0FD" modified="2022-05-25" version="1">MNEKLIHESLNIVSGDPGNRTDDISEVGCGVRCKIDQCEKGCAAWEQALETSCQSTCNGTQELLPPKELYCVLGCHDALNRYFQQLKAEIGVPPAPALVADSLTATSLRLEWKGVDIKRRAAGISYLVQWRYEELAETWQYCRNQSWGEDDQILVDNLQPYTKYRFRVALLLKSSQHNPEPIVSAPSVVILTLAAGSPSSAPVIVRAAAVDSYRVSVSWEPGPFPNGPLLSYVLQLQGDDFFLLNKDIPASENTDHYMFQNLKPNQNYSVSVSMRNAVGDGPPAVTYITTPPEPAVKDTQQPILILGGEHVVMKQGADMLDEPSIIYRANGRIRGVAIHVSSAQLFVSDSMGYIYRTTILKETEPIVVLRPDQANFKPLSLSVDWLNSHLYILGEVNHATTVWQIARCNLDGKGLTVAMAGFMTRPTHIEVDPYNGYLFWVTRGGLFRLDLADISNGIKHEVQPYLILEDTHLGAFTVDHTNFRLLVPDHTQNTVISVSLDGREVLNLRANTQQPKFTHVVSLAMANGLFYWTNGVEVLTEGYHSGQNRYFHNAYPDRSDGSFVSVNVFMDASQPVPVPVNPPTGVQAVLGAERAKVSWQAPHLLGGQGKGAWQNWSYELEIKDESTGHTVQQRNITGSSHTVYNLREKSEYTIKAAAYTHAGRGPWSSEFRGKTLRENSHASILWSANEGLLKSDVTGENVNTLIYKDMLKDNDNDYHIIDASWYEDTLYFVGNNSALYRYNITSHQKTKLNINSVGTVAVDWFAKKLYWANPKQQIITRANLNGTQQEPMSILAIVKELIIDSQEAYLYWSTGHAVEVARLNGLDRRYYHSDEIFNGKQVMGLTIDTENRYVYWIVRSYESGSIVYRAPTSERVPMNQRLVPEKVSSLQYPNIQGPLCYFSEHLLWLQDDRNAVIGDLTGQNTAMINGISLIGLHMVAIMDPALHQYPPGLTADNITVIPRAVSLNSIRVIGTWGNFNVSWDPVNNINHGTVFYEVKFANYINANANPEITTNTTMLYNNSEQILPYSLLEVTIKAFTYWGAAMHTRKVLRSPQSEPTQPTNVRGFVEFNRAPINIDANEHHHDHHDNVDITITFRWDPPEYPNGIIKGYNLHCWFLNNSKNVDVFNGLEVQHDKWEYVVNNLRANTTYYFEVQAFTEVGAGSFADMINISTENEDPVPQLIVASVDALKLVDLDLKSEVILTRHVAIEMRYVTLDDKLYWINEMQEIVMANFNGTNTTKILSLNNTATSMCVDWISRNLYWSEYQRKSGVSSILKLDLTAWESSGTLIYEKIVTNSRNIINLEVSPLTGDLFWIELTAGKHGSIVQSDLYGSNIRPFFNHDDTDCSCPYRPLIKPSMTIDSTDPHNPVMYWTSMEEHLNIAGINGCVCSEVISSGFNRGLPPISLTADKINVYWLDTAGSGIHYVNKNYPYEQDIKRIYFDNIRTIKAIGKSLQSYPNSDCLIPYQMSYTVEELVKKSNSITVKLPNPETHLGCEKYNLPGTLFTIQVSRCHDSTTCDTNDILEFKTYKKEFEIVNLQPFTMYQFKLALSNYYSDIIKVKREFGNPIVLRTAAGAPSAPQNVTVKSCTPTLAAVYWLAPRILNAAAVRYEIHWRSLRLVNGERPKGEKLIKNLGKAADGRFMELLKPLLPGQDYLVYIRAYPADSNDTYGESEGQIVSMYPEPNNLTNIASSVNTLNVTWVPMVNVTINHTLEFTAVGLEKWQVADSFAVGKDNKIEYCIRGLMPRTLYKFRLILRYPNYHDDFVWPADARFTFQTSGDVPSPPGKPSVTKLRNSVYQLNWEPARAHGSQVKMYRLEGKIIDNDLDGLKAGQDNEGWKLYYTGTDNYWIIVGEMNQKYKFRVQATNAYGSGGWSETSGIIDLTDTIGTTLASQQHLGLILGLSVPFVIIVLICFCYFLCLYNRRRKEVKKSILPPVMSDVELATLREIPRGVSNMAYFADENQIHYSGNSWKSSSSEGSRDMQPFLQDTSSTTVTTIRLSDVELPKYLELLAESSGVIIKPQTDEYEVPRSIQIVPSLADKKIGQPDLATKPSELPRREITPEDREHLDNILSQIGTLNTTERSKTLDNLRLKNNAKVINAFKNGLRASLNERTSRQLSSNINNKNNDGSSKISLDDRNCSSLGSSISSLRGSLPSTRPSSSVLGSQHNLPLKNINHSNNYNYSNNNNNNNNNLVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HH44</accession>
    <name>A0A8J2HH44_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Similar to SCCPDH: Saccharopine dehydrogenase-like oxidoreductase (Homo sapiens)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HICCMSTLAB_LOCUS10158</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the saccharopine dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5101085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HH44"/>
    <dbReference type="OrthoDB" id="10268090at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009247">
        <property type="term" value="P:glycolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000178">
        <property type="entry name" value="Saccharopine dehydrogenase-like oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051276">
        <property type="entry name" value="Saccharopine_DH-like_oxidrdct"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005097">
        <property type="entry name" value="Sacchrp_dh_NADP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12286">
        <property type="entry name" value="SACCHAROPINE DEHYDROGENASE-LIKE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12286:SF5">
        <property type="entry name" value="SACCHAROPINE DEHYDROGENASE-LIKE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03435">
        <property type="entry name" value="Sacchrp_dh_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="267"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="Saccharopine dehydrogenase NADP binding" evidence="3">
        <location>
            <begin position="8"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG5101085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="421" mass="46349" checksum="FF7F0E90855A16C6" modified="2022-05-25" version="1">MAENRLDVIIFGATGFTGNYTVKEAARLSKAKPFSWGIAGRNKERLDAVLKKFAPEEENISVIIADVKDEESLKKMAEKCKVVVNCCGPYRFYGEPVIKACIAAGTHHVDVSGEPQFMEKMQVEHSKAAQEAGVYIISACGFDSIPCDLGIIFVQQKFGGEVNSVETYLKTKVDGNFRGASLHYGTWESAVYGLAYANELRELRSKLYPDKLPSFEPKLHPRGIVHSSEISQRWSLPFPGSDRSVAYRSQRYLYEKNKIRPAQVQTYMILSSIWAVISVACIGAVFSLMTKCKCGRSLLLKYPKFFSGGLASHEGPSPEAMEKTYFSITLKASGWKDKLAEPTDKHTEPPNKEVIAKVSGTNPGYGATCTMLMISALTVLREADKLPDKGGVLPPGAAFANTSMIEQLNNNGVKFEIIKAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HHC0</accession>
    <name>A0A8J2HHC0_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Proteasome subunit alpha type</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HICCMSTLAB_LOCUS7695</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="1">The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the peptidase T1A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5095410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HHC0"/>
    <dbReference type="OrthoDB" id="3145928at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019773">
        <property type="term" value="C:proteasome core complex, alpha-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050115">
        <property type="entry name" value="Proteasome_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023332">
        <property type="entry name" value="Proteasome_alpha-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000426">
        <property type="entry name" value="Proteasome_asu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11599">
        <property type="entry name" value="PROTEASOME SUBUNIT ALPHA/BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10584">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00948">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00388">
        <property type="entry name" value="PROTEASOME_ALPHA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51475">
        <property type="entry name" value="PROTEASOME_ALPHA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2 3 4" id="KW-0647">Proteasome</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proteasome alpha-type subunits" evidence="5">
        <location>
            <begin position="5"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS00388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAG5095410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="194" mass="21637" checksum="257C3D8CC515D921" modified="2022-05-25" version="1">MSARYDRAITVFSPDGHLLQVEYAQEAVRKGSTAVGVRGNDVVVLGVEKKSVAKLQEERTVRKICLLDDHVVMAFAGLTADARVLINRAQIECQSHKLTVEDAVAIEYITRHIAGLKQKYTQSNGQEVATERGSIKLAIRALLEVVTSGQKNLEIAIMRRNEPMQMLDSDTIGEYVTEIEKEKEAEAEKKKQKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HI30</accession>
    <name>A0A8J2HI30_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Similar to RF_0381: Putative ankyrin repeat protein RF_0381 (Rickettsia felis (Strain ATCC VR-1525 / URRWXCal2))</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HICCMSTLAB_LOCUS8176</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5096370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HI30"/>
    <dbReference type="OrthoDB" id="8193571at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050663">
        <property type="entry name" value="Ankyrin-SOCS_Box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24193:SF121">
        <property type="entry name" value="ADA2A-CONTAINING COMPLEX COMPONENT 3, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24193">
        <property type="entry name" value="ANKYRIN REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="70"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="109"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="210"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="326"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="366"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="399"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="29"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAG5096370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="673" mass="76563" checksum="8D98FA56A153E0F1" modified="2022-05-25" version="1">MSEHGCPVKRIRLDSSTSKSGDLPEDDSYSVLSLSDDDVSNVSSQENSTDYTRDSELGNSGVDIDTPGQRNLTALHLAINNKYLPGIKCLLEYGASISATGEAYHINNHGDTPLHVAVKEDRLDIVKMLFTIQVDINKLMKNYDKVLSHALKRRNYKIIKCLAGFSVHENDNLKRRAFNLFSRQKLRMMGYNDNVIDSLFEKYIVVNSKNHGTPLLLAVENRNLDMIEFLLENGSDINAIAFTIVINMLLLKKEDCDFNFKENDYSLTPLEVAAASNNLKIVQKLVDKIFQHDGYGTDKFKHVLKTFHIAIKENFVEITKYFLDTNGESALGTAIYANQVGMAELLLNSGANINYYSEYVDRGFNREDPPLYCAVQRGSIMMVDLLLSRGARINEEKFTKTTILHLAVSSKNNEIVKRVLDLGVDVHCKREIYPYDNVSPLLLAIHLIAKEIVLMLIENGSNITDKATIKGKCVSVIDIALKRGNNFLIMLLNLGADIDDATINDSKLPQNTLKILERHILKLKAARLFVDHKFDAWISRAMEENRFYKKCRKEVKKMKEEKFYQCTLTMPAKLFVNEKLNGWISRGPTKQEFFNKCKKEVKKMQKEKINQTSSFCYFDLLNEKASAVAEFVETTSLVSEFYNSLVGFPLYGEMLTCHFEKAQQSNRNVFKNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HJD6</accession>
    <name>A0A8J2HJD6_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ubiquitin carboxyl-terminal hydrolase</fullName>
            <ecNumber evidence="6">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HICCMSTLAB_LOCUS9566</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the peptidase C19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="6"/>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5100463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HJD6"/>
    <dbReference type="OrthoDB" id="21192at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050185">
        <property type="entry name" value="Ub_carboxyl-term_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001607">
        <property type="entry name" value="Znf_UBP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646:SF19">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02148">
        <property type="entry name" value="zf-UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00290">
        <property type="entry name" value="ZnF_UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50271">
        <property type="entry name" value="ZF_UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="6" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="UBP-type" evidence="9">
        <location>
            <begin position="1"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="USP" evidence="8">
        <location>
            <begin position="182"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="104"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="153"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="104"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="115"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU366025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAG5100463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="538" mass="60941" checksum="C0A52C6F67B21B50" modified="2022-05-25" version="1">MECPHLAQSVRLGSNDIEWNDIKNLPFVCAVCGTEKSTWLCLHCGNVHCGRYMSGHALQHHEKNTHHCVCIDCENLSVFCYSCDEYVVNDTSTGQIEKIRQNTFRKAEHKENDENWSSSSSSGLDNGNGDTDSDAIWKNEVVVRNLRPRTRKRLHSFDETSGDNRPVPKRRSSKATKEKKVVGLRNLGNTCFMNAVLQSFNNISHFCEYLTQMPSLEGIAFDEPPTHRGRIVAPGRAKELSDALLAEELRKVLLGLSLGSSNGQAISPECLFLVIWKVVPRFRGYQQQDAHEFLTYMLDRLHTELLQLLPRLGHEPLGLRGKQSIVTAVFGGALLSVVHCMNCRTDSKTHEPFQDLSLDIPDKFQRRTATKEQEEVCSLTFSLSRFFKVEELADSELYYCNNCMGKQRSTKRFWIHRLPNVLCLHIKRFRWCNSYRSKVDTQVDFPMESLDMSTFTVCGSAGVKIGAQNSHLYDLAAVIVHHGSGAGTGHYTAFAVHDGQWFHFNDSSVRPASTESVAKCKPYILFYVRREFSIPPPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HJE3</accession>
    <name>A0A8J2HJE3_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Odorant receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HICCMSTLAB_LOCUS9009</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Cell membrane</location>
            <topology evidence="1 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the insect chemoreceptor superfamily. Heteromeric odorant receptor channel (TC 1.A.69) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5098052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HJE3"/>
    <dbReference type="OrthoDB" id="7179992at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005549">
        <property type="term" value="F:odorant binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004984">
        <property type="term" value="F:olfactory receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004117">
        <property type="entry name" value="7tm6_olfct_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21137">
        <property type="entry name" value="ODORANT RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21137:SF35">
        <property type="entry name" value="ODORANT RECEPTOR 19A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02949">
        <property type="entry name" value="7tm_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 10" id="KW-0552">Olfaction</keyword>
    <keyword evidence="8 10 11" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="9 10" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="47"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="74"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="135"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="249"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="355"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU351113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAG5098052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="376" mass="42807" checksum="699A7898BF248A95" modified="2022-05-25" version="1">MKLSTESRGFRITPEKAVKFIKVSVYLTCMWPPQGDESKISFKFRKYLSVFLSFGLFFPLLFSIVIYFNDMLIILKSAICMTALVNYISKVIIVTRYHREFEKFRSVLNEFILKASDSSKVVFQKYVDKFWKFQFFMVFCYYFGATGIIMGPLVLPQKFPTDAVYPFSVENPVVAGIIYAHQGFAAYLGAAGMVLDGQAALFLWYLNAKFDILVSEINRVAKREDLCWYIRQHQEILAFADELIPPIRALAFTTISVTKILMISSGFFLISDESLLVKLQFVMVAISSTFNTFLYSWAADDLINLSGAAMSSEIFNVFYRHSLKTKKICLFIIHRAQKPIVINIPGLLATLSSEYYASFLSAAFSCFATIHAVVNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HJG2</accession>
    <name>A0A8J2HJG2_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Similar to ZNF474: Zinc finger protein 474 (Bos taurus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HICCMSTLAB_LOCUS9040</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5099391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HJG2"/>
    <dbReference type="OrthoDB" id="265955at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026319">
        <property type="entry name" value="ZC2HC1A/B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049899">
        <property type="entry name" value="Znf_C2HC_C3H"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13555">
        <property type="entry name" value="C2H2 ZINC FINGER CGI-62-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13555:SF68">
        <property type="entry name" value="ZINC FINGER PROTEIN 474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13913">
        <property type="entry name" value="zf-C2HC_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52027">
        <property type="entry name" value="ZF_C2HC_C3H"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2HC/C3H-type" evidence="7">
        <location>
            <begin position="365"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="domain" description="C2HC/C3H-type" evidence="7">
        <location>
            <begin position="431"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="domain" description="C2HC/C3H-type" evidence="7">
        <location>
            <begin position="481"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="domain" description="C2HC/C3H-type" evidence="7">
        <location>
            <begin position="541"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="domain" description="C2HC/C3H-type" evidence="7">
        <location>
            <begin position="617"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="251"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="394"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="450"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="515"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="284"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="309"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="339"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="456"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS52027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG5099391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="644" mass="72784" checksum="240B7875693334E7" modified="2022-05-25" version="1">MKWKRGSMDFFPEKTFLIIKDNVETFSVKKSYRRMKSKSAADTTGTWPPKVKKNSLFVAVERPKTANLERPAVLNPALVNKLDMSLLSKERLCDSMTRIQLDRRATTSITVSGGGYTLPANNNKQVHQQQATSIVQSSNNSIASLTEAKTFFIRSKRPTFQHLIINNYYLYDQPTTTTMPVNHKLDPVIVKKSPSPVLNNNRQTIKLTENKITGSSLSIVRTSKSSRLALPEELKVFTTSATVNKLKTPEPCKTCGRPDQPERFHSHPKGLPLKGITDNKDKNNNNNNNNNTKDNVKKSIQKPVALNYKSDKNKDKSTKNNNKYGQNDCFVEKDKKKLSSPNSSDSNNENYSKSRPGSVNKKGPRTVTCYICSREFGTASFPIHEPKCMEKWERENEALSPSQRRPRPQRPELPLNHHQWNNVAWELSQTQLLPCSKCGRTFLPDRLPVHQKSCKNSKDTASDKSDRTEKPRSSTSQSGSSTIFCQTCGRNFGARTIKIHEPQCLKRWQAANNISSDDNKKKQDKSSGGSCSNNSRELVKPTTTCYICGRDFGSASIDIHEPQCLKKWHIDNDKLQLSQRRYQPIKPILADTTLDTASPVINWAATTEAKWKSHLGQLIPCKNCKRTFNPDRVAVHERTCKGTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HK17</accession>
    <name>A0A8J2HK17_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Similar to unc-130: Forkhead box protein unc-130 (Caenorhabditis elegans)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HICCMSTLAB_LOCUS9568</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5100467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HK17"/>
    <dbReference type="OrthoDB" id="5954824at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009653">
        <property type="term" value="P:anatomical structure morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20035">
        <property type="entry name" value="FH_FOXQ2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000352">
        <property type="entry name" value="Forkhead box Q2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047519">
        <property type="entry name" value="FH_FOXQ2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001766">
        <property type="entry name" value="Fork_head_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050211">
        <property type="entry name" value="FOX_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018122">
        <property type="entry name" value="TF_fork_head_CS_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030456">
        <property type="entry name" value="TF_fork_head_CS_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11829:SF343">
        <property type="entry name" value="FORK-HEAD DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11829">
        <property type="entry name" value="FORKHEAD BOX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00250">
        <property type="entry name" value="Forkhead"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00053">
        <property type="entry name" value="FORKHEAD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00339">
        <property type="entry name" value="FH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00657">
        <property type="entry name" value="FORK_HEAD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00658">
        <property type="entry name" value="FORK_HEAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50039">
        <property type="entry name" value="FORK_HEAD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fork-head" evidence="5">
        <location>
            <begin position="122"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Fork-head" evidence="3">
        <location>
            <begin position="122"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="56"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="212"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="212"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="232"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="273"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAG5100467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="439" mass="48732" checksum="F91572D7E32A696F" modified="2022-05-25" version="1">MCNNESPPPAKEPLTIGLGIGVGGAMAGFLPFEHYRLQLYHYASMAERLRLAHQLHPQHPGVGHPTSGGPGSHLGMSPGFSAPLPLYPAAAAAAAVASYPNRLALSMALLHPHHPRMPEEPKPQHSYIGLIAMAILSSPDKKLVLSDIYQHILDNYPYFRSRGPGWRNSIRHNLSLNDCFVKSGRSANGKGHYWAIHPANLEDFRRGDFRRRKAQRKVRRHMGLAVDEEPDSPSPPPLPATPPPPTGLVGPPVTSQPITALWSPQHHHHHHQAQQSNNHQLQQLSPQSPHSQHQHQRHIQNLPLLRMSYQPSRKRQFDVASLLAPDDQQIDDVESVVIRTTKTRKYSCSEDEQETDHIDQDDEDVDVDVDVVAEANPLPSPGTPSASPDTKMISPSNQCDWNEPTAIKTTQPLSSMHLHNHLHIRNYYIQANATSTSSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HKI9</accession>
    <name>A0A8J2HKI9_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS12058</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5106022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HKI9"/>
    <dbReference type="OrthoDB" id="7691162at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5106022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="204" mass="23786" checksum="AB40858B0CE2D75E" modified="2022-05-25" version="1">MHPRQFAVIDKSRRVYKTFRLDTVFISFSDCALRNTTLAIVLLLFTRFSSIMKNYFILSSIFLSLLITDIYPQNISSIVGNDYVLRSCVSTVKLIRNHRKTVPRVDTLENTGKSITTDNSPNVNLIMNSRQQLNYNSRVERDRKNRLRGKITTDSPVKTVNIMRQRKSEPLLFRKKNGFPEVFQRAEQRRTKIKSEIITIKPVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HKX1</accession>
    <name>A0A8J2HKX1_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Similar to Cdk10: Cyclin-dependent kinase 10 (Rattus norvegicus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HICCMSTLAB_LOCUS12345</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5106609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HKX1"/>
    <dbReference type="OrthoDB" id="1732493at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007346">
        <property type="term" value="P:regulation of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF508">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="142"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAG5106609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="192" mass="21630" checksum="BF462596D741A78B" modified="2022-05-25" version="1">MVAKDENIGKQLDQNDVDKKGSSIEIGSDPSAPITRRGELLGHKPLLPGRSEIAQLELIVDLLGTPSEAIWPEFNSLPALQNFTLKQQPYNNLKQRFPWLSAAGLRLLNFLFMYDPKKRATAEECLQSSYFKEAPLPCDPKLMPTFPQHRNMKKSSQPRDVREPEPPVSDQTNNLPAISDLLGSLVKKRRVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HL83</accession>
    <name>A0A8J2HL83_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Similar to TBC1D25: TBC1 domain family member 25 (Homo sapiens)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HICCMSTLAB_LOCUS7988</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5095996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HL83"/>
    <dbReference type="OrthoDB" id="10264062at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005776">
        <property type="term" value="C:autophagosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901096">
        <property type="term" value="P:regulation of autophagosome maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.270:FF:000041">
        <property type="entry name" value="TBC1 domain family member 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22957:SF333">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22957">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="3">
        <location>
            <begin position="200"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="631"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="631"/>
            <end position="647"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG5095996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="860" mass="97638" checksum="128A4C1EFB7C1295" modified="2022-05-25" version="1">MTEMFGSPREAVRVKVKKCETRHQPEYRKFSVDPQITSIEVLQSILIKAFDIKGEFTVSYRAIDDYGSETYLFLLSDWDLDAAFISASEPYLYLQVNLKPFGESGDCGCDWEQSSRELTIKQESGFPYKTPKLPGLIMNKVEKTFNMVQRALGNLGEESSQQNIQPPRPPLTDAEFRKFLDPIGQVIHSKELRAVIYFGGIEPSLRKVVWKHILNVYPDGMSGRERMDYMKRKAQEYQSLRERWKSLMQKGQNVGDLSYVTSMVRKDVLRTDRHHKFYGGSDDNQNIASLFNILTTYALNHPSVSYCQGMSDLASPLLVIMRDEAQAYICLCALMRRLKDNFMLDGIAMTTKFTHLAEGLQCYDPDFYAYLKSHQADDLLFCYRWLLLEMKREFALEDALRMLEVLWAALPASPPKDELHLAEVPFPPPTPPPSPNIKHIRENAYTKVCAIRRLSSSASIASGKKKFSSIDDHGETSIIENRSTSPKIIEPETDSQITSTKNRKNNTLVDRLSNNEALEAKSKISSNSYEIKTTKSLDETKVNELTENEKKCARVVKNLNEFLNFTSLNRNKVGPSDKRELKRVSSENGVIRVVRDDAGSPDDPTDFYPMTTSMTRELRLELESLDRQVFGSSTSNEANGSDCATSKQDSDEPDSEIEFDTEVPKCSPAADVFVWENPLHSLKNKISAFVTTPDESTETEYDGEILEDQNGVKSVTPIRLLKRTARTDCTSDNESPDSWRESAIALDNQLTVTQEQCEEATELTALIPAGTCDDQLTGLLPPPSEFGGGNPFLMFLCITMLLQHRDFIMRNQMDYNEMAMHFDKMVRRHNVARVLSQARQLFAGYLRRYSTPGRPDYVSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HLC6</accession>
    <name>A0A8J2HLC6_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS9798</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5100725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HLC6"/>
    <dbReference type="OrthoDB" id="7697689at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="10"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5100725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="219" mass="24804" checksum="B48018B08FF9B632" modified="2022-05-25" version="1" fragment="single">NPSHNDTENRSSSSDISDNSDSDNGSCNEESNDRDHDNSDDPDTIISDNSDQYKLENSLKSLSFHSELTPLETTTSVSEVSAETRLPVINQALKLLNESSIAPRKLSDERFLYDKVIKISQTLKSTFGLEVNASTNLEDSDRDFSNLLEQLKKKFDHDETTRSEKIQILTLFPKEWSVRRISEFMNISRHLVNVAKNLLETKVLLSKPESKLGTLFGFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HLK2</accession>
    <name>A0A8J2HLK2_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Coatomer subunit delta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">HICCMSTLAB_LOCUS10071</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="10">The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 10">Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10 11">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10 11">Cytoplasmic vesicle</location>
            <location evidence="10 11">COPI-coated vesicle membrane</location>
            <topology evidence="10 11">Peripheral membrane protein</topology>
            <orientation evidence="10 11">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10 11">Golgi apparatus membrane</location>
            <topology evidence="10 11">Peripheral membrane protein</topology>
            <orientation evidence="10 11">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the adaptor complexes medium subunit family. Delta-COP subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5100998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HLK2"/>
    <dbReference type="OrthoDB" id="10266042at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030126">
        <property type="term" value="C:COPI vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051645">
        <property type="term" value="P:Golgi localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd09254">
        <property type="entry name" value="AP_delta-COPI_MHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14830">
        <property type="entry name" value="Delta_COP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1170:FF:000007">
        <property type="entry name" value="Coatomer subunit delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.60:FF:000003">
        <property type="entry name" value="Coatomer subunit delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1170">
        <property type="entry name" value="Mu homology domain, subdomain B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036168">
        <property type="entry name" value="AP2_Mu_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027059">
        <property type="entry name" value="Coatomer_dsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028565">
        <property type="entry name" value="MHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10121">
        <property type="entry name" value="COATOMER SUBUNIT DELTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10121:SF0">
        <property type="entry name" value="COATOMER SUBUNIT DELTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00928">
        <property type="entry name" value="Adap_comp_sub"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49447">
        <property type="entry name" value="Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51072">
        <property type="entry name" value="MHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 10" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="5 10" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="7 10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="domain" description="MHD" evidence="13">
        <location>
            <begin position="228"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="105"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="14">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU364018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU366052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CAG5100998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="469" mass="52266" checksum="858468978765FEA8" modified="2022-05-25" version="1" fragment="single">VLISAAVTTKNGKTIVSRQFVEMTKARIEGLLAAFPKLMSTGKQHTFVETDSVRYVYQPLEKLYMLLITTKAIALGYRESVNLAQIRTFVEMDSHEERVFQAVRFTQEREAKNKMREKAKELQRQRMEANKKGGAKSPNFGSGYGNSSSNFTPTANVVGDSANYVPEPVKPSYMPSKPSAGSGAMKLGGKVRDVDSFVDQLKEEGETVASNVKVDTKIAPIIPQAANTELVHLRQEEKLNVRVGRDGGVQHFELHGLVTLHIKDEKWGRIRVQLENEDSRGIQLQTHPNVDKDLFRTHGQIGLKIPTKPFPLNTDVGVLKWRLQSHDETALPISINCWPSENGENGCDVNIEYELEQTDLELNDVQINIPLPMGCSPIVNECDGQYTHEARRNTLLWSLPLVDASSKSGSMEFSAPSSTPSDFFPLKVSFTSKTSYAKIKVIDVLLVEDESPVKHSVDTVFSTENYEVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HLK7</accession>
    <name>A0A8J2HLK7_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS12290</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5106498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HLK7"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5106498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="95" mass="11036" checksum="E58F714EAF1C5486" modified="2022-05-25" version="1">MWAKYSSTYLESSLWWSHWYGIGLNVKGGGCVDICNTENRVCTIKSSSLDKEEINQHPGVIVYELGLLLWIICKTTNRTWNTFSINFSRMRKEII</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HN02</accession>
    <name>A0A8J2HN02_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Olfactory receptor 33.1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS9245</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5099809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HN02"/>
    <dbReference type="OrthoDB" id="6617147at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0675">Receptor</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="24"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="246"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5099809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="273" mass="32099" checksum="5646D2109123B5D8" modified="2022-05-25" version="1">MFDKVKWIIEFLNAWPINPTKKKLIFFLLYLIHENVYLAMAYYDLFSIFGDLQLMSTNLIGTLVQMIMMIRLIFVKFSSRLRNVIVEIKADVCDENYQRTDEKIIYIKYSEMATNFYKITMGFELPYRAKLFNTNETTLKQSIFLYIYQAPMPITALCYFATVNMQFIIISNICARIAILRNRINQINDCMPMKTDSLIKHIVHQNLQEMFYICNWQEMSQKSKQSWLICMVSGAKIPMQITAGKIYIFSFNSFTGILRSSMAYVSLLRTLTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HN31</accession>
    <name>A0A8J2HN31_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Similar to SOX2: Transcription factor SOX-2 (Gallus gallus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HICCMSTLAB_LOCUS10671</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5101770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HN31"/>
    <dbReference type="OrthoDB" id="6247875at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007420">
        <property type="term" value="P:brain development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030182">
        <property type="term" value="P:neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01388">
        <property type="entry name" value="HMG-box_SoxB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.30.10:FF:000002">
        <property type="entry name" value="transcription factor Sox-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022097">
        <property type="entry name" value="SOX_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050140">
        <property type="entry name" value="SRY-related_HMG-box_TF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10270:SF324">
        <property type="entry name" value="SOX DOMAIN-CONTAINING PROTEIN DICHAETE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10270">
        <property type="entry name" value="SOX TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12336">
        <property type="entry name" value="SOXp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HMG box" evidence="8">
        <location>
            <begin position="133"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="6">
        <location>
            <begin position="133"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="65"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="313"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="392"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="71"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="324"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="400"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAG5101770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="431" mass="47452" checksum="B4525922E997031C" modified="2022-05-25" version="1">MLTMDADLKGGNLHGQIPPHPHQGVSPMSHHASMSPYGSLGPIVHSQALSSGSPPNSAALSALTLHHHQQQQHFASMQAMQQQQQQQQQQTMHSLAQHSHQQAQQPPQPAQQQHQPTNNNNNNNSKNNNVDRVKRPMNAFMVWSRGQRRKMAQENPKMHNSEISKRLGAEWKMLSEAEKRPFIDEAKRLRAVHMKEHPDYKYRPRRKTKTLLKKDKYPMANANAGLINMDPRQVNPSNPAQQSQIPRDIYNGYMPNGYVMHDGSAYPQHPYAGHLAGYQRYEIPPHMAGGNSSPLNSYVNGYANYGGAIPAGSPSPYHSAQPGSQMSSHSPSGSSIKSEPTSPASAGIHTPTPISSAPGSQVKREYLAQQNPSQGGDISQMISMYLPPNNQAEQRIQHNPGGVYSPGPGPSPDSLIPHHTGMPVSLNHHHM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HNJ6</accession>
    <name>A0A8J2HNJ6_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similar to Fam135a: Protein FAM135A (Mus musculus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS11004</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5102416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HNJ6"/>
    <dbReference type="OrthoDB" id="273452at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="257"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="473"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="544"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="266"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="306"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="551"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5102416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="591" mass="66176" checksum="0CE5F964D1416FAD" modified="2022-05-25" version="1" fragment="single">MNYPVKDDLETTTRCVGSTARTQHARATQREVTRILLTARENLLNDIADLARLLPSREQRDLEIAERKHKEASKMIDTDEVDIAQLCAQNIVLWHIFLEAFSKQEPVHQHLARIHHQLRVKRFSEGFFVLENPRTSAAGCYDANYQSYQAVSEAARRSRYLAALPPLPVHCPELDGDLNSLPLIFEDNYADMQQRHRNSVPSIEDCSCGISAILESRGSSVWSPRSEGAAQDIASIQARLSLGPTSLPARHSKSLDQLGPEIASPQPRTSPKTLPRSASTQLFPRQRSGGRNPTPPTSVPSKGRSRSQAPLHTARSTTLFPPSGQQQAFSAPNPSLGSTPVMPLPRAKSTQMLVANSGHEYMQPSTSITSLLAAMFPELPPNGHFPGYRPSNKTCEFGIPSCNFDLNNKFGSFDSNHKPESNSTGNQRIRLEPRSHRLFHHDKSLNIPNGVFDQTNSGNMRSATLDRVTYRGNHRKQAAKSNTDNRRYHTLGKSSGHPERVKSQDFLNTLNGDAQSHTLLVDPLNKRFSGVYGDVNVDSFFYRTNGTSGKNSDRPKRPKSTERLFDVGRVDYSQDKENYERDRYINSRFRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HNP9</accession>
    <name>A0A8J2HNP9_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Similar to eg: Protein embryonic gonad (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HICCMSTLAB_LOCUS11110</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5102629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HNP9"/>
    <dbReference type="OrthoDB" id="5850793at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050200">
        <property type="entry name" value="Nuclear_hormone_rcpt_NR3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001628">
        <property type="entry name" value="Znf_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48092">
        <property type="entry name" value="KNIRPS-RELATED PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00105">
        <property type="entry name" value="zf-C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00047">
        <property type="entry name" value="STROIDFINGER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00399">
        <property type="entry name" value="ZnF_C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00031">
        <property type="entry name" value="NUCLEAR_REC_DBD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51030">
        <property type="entry name" value="NUCLEAR_REC_DBD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Nuclear receptor" evidence="11">
        <location>
            <begin position="88"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="204"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="308"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="206"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="308"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="363"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="376"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="386"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAG5102629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="413" mass="44957" checksum="603020993DD61128" modified="2022-05-25" version="1">MDVGDLSNAAGLAASGAAVFGPATTSASRFSNRNTVNINIDNNNSNNFIDNGNPDSGGQVGASFHPSAGWWTPSSTLVTAPANADVMNQLCRVCGEPAAGFHFGAFTCEGCKSFFGRTYNNLGSISECKNGGVCVINKKNRTACKACRLRKCLMVGMSKSGSRYGRRSNWFKIHCLLQEQSHQAQQRLKESTKLPFDKVASLDAANNNTNNNNNNNNNNNNSNFAAASGLGMPDRKEDPILSPRLPPRPDLLPHELLRPEITRFPLWRGPPFFHPLSPMQLLNTPFFPFQQRFMVPYINNQASQQVPVTSLSSSSSESVSPRSTPSPKEFLIEKSEASSPPTVGDKGLAFLRSLGPEQEEPMDLSRKSSEVKDILDESCDSDDSVDEKPVIADNLQEKVSTDANPPLDLSWKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HNS5</accession>
    <name>A0A8J2HNS5_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">acid phosphatase</fullName>
            <ecNumber evidence="3">3.1.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HICCMSTLAB_LOCUS12424</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a phosphate monoester + H2O = an alcohol + phosphate</text>
            <dbReference type="Rhea" id="RHEA:15017"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:67140"/>
            <dbReference type="EC" id="3.1.3.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the histidine acid phosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.2" evidence="3"/>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5106766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HNS5"/>
    <dbReference type="OrthoDB" id="5821688at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003993">
        <property type="term" value="F:acid phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07061">
        <property type="entry name" value="HP_HAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000560">
        <property type="entry name" value="His_Pase_clade-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050645">
        <property type="entry name" value="Histidine_acid_phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11567">
        <property type="entry name" value="ACID PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11567:SF211">
        <property type="entry name" value="PROSTATIC ACID PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00328">
        <property type="entry name" value="His_Phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035324333" description="acid phosphatase" evidence="8">
        <location>
            <begin position="22"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAG5106766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="370" mass="42906" checksum="AD1AD83B0C78AAFE" modified="2022-05-25" version="1">MVLILMIPVILVLIIVSMCYGEIRMFQAPIRHGNRYPTQKAYAVKFYPNDPYINYTWAPYGSMKLTNKGKINTYKLGKLFQNRYKNLLGTIYKANEIFFGALDSNRTINTAQLIASGIYPEFRQRRNQSSGPIQASVHVEVGEKNLYYPMIFCENYFIDRQKADLIVAGLFDREELQKFSDYLAVHTTVKFSPFLHSWFLYNSFVAQVDLGLELKPWTDSIFPNGKLLEMTAFEYRLQTYTNRMKRLVGGVWIKSFLDHADNFVNHVSSDQKANFFVASEMHVAAILNTLGVYTPHFPSYLSAVIFELHEINREFYIQVVHRNEDRSSVLIIPGCDGALCRLEQFKKVLKDVTLYNFDKDCGNRDFFPIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HNZ9</accession>
    <name>A0A8J2HNZ9_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Similar to Tbl1xr1: F-box-like/WD repeat-containing protein TBL1XR1 (Mus musculus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HICCMSTLAB_LOCUS13157</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the WD repeat EBI family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5108277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HNZ9"/>
    <dbReference type="OrthoDB" id="1367865at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000118">
        <property type="term" value="C:histone deacetylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.960.30:FF:000001">
        <property type="entry name" value="F-box-like/WD repeat-containing protein TBL1XR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000014">
        <property type="entry name" value="Putative F-box-like/WD repeat-containing protein TBL1XR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.960.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045183">
        <property type="entry name" value="Ebi-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006594">
        <property type="entry name" value="LisH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011045">
        <property type="entry name" value="N2O_reductase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22846:SF2">
        <property type="entry name" value="F-BOX-LIKE_WD REPEAT-CONTAINING PROTEIN EBI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22846">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08513">
        <property type="entry name" value="LisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00667">
        <property type="entry name" value="LisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50974">
        <property type="entry name" value="Nitrous oxide reductase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50896">
        <property type="entry name" value="LISH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="2 7" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="162"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="224"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="258"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="341"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="383"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="434"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="96"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="98"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAG5108277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="511" mass="56236" checksum="36BF7B38386AD7EF" modified="2022-05-25" version="1">MLRKMSFSSDEVNFLVYRYLQESGFQHSAYTFGIESHISQSNINGALVPPAALLSILQKGLQYTEAEISIGEDGTEQRMIESLSLIDAVMPDVVVSRQNQQNQQKQQIKTDTQDTNGEEVVTSNERSGDKTEMESEEQQTGGVGVGSNASAIEIPANKATKLRGHESEVFICAWNPTTDLLASGSGDSTARIWDMSDNSSTPQQLVLRHCIQRGGAEVPSNKDVTSLDWNCDGTLLATGSYDGYARIWTTDGRLSSTLGQHKGPIFALKWNKRGNYILSAGVDKTTIIWDAASGQCTQQFSFHLAPALDVDWQTNTSFASCSTDQCIHVCKLNVDKPIKSFQGHTNEVNAIKWDPQGNLLASCSDDMSLKIWSMKQDTWVHDLRAHHKEIYTIKWSPTGPGTHNPNMNLTLASASFDSTVRLWDIERGVCFHTLTKHTEPVYSVAFSPDGKFLASGSFDKCVHVWSTQTGQLVHSYKGTGGIFEVCWNSRGDKVGASASDGSVFVLDLRKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HPH2</accession>
    <name>A0A8J2HPH2_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Endonuclease/exonuclease/phosphatase family domain-containing protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS12397</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5106713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HPH2"/>
    <dbReference type="OrthoDB" id="6237065at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.320">
        <property type="entry name" value="Photosystem II 12 kDa extrinsic protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051675">
        <property type="entry name" value="Endo/Exo/Phosphatase_dom_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003583">
        <property type="entry name" value="Hlx-hairpin-Hlx_DNA-bd_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21180">
        <property type="entry name" value="ENDONUCLEASE/EXONUCLEASE/PHOSPHATASE FAMILY DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21180:SF32">
        <property type="entry name" value="ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE FAMILY DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12836">
        <property type="entry name" value="HHH_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00278">
        <property type="entry name" value="HhH1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="RuvA domain 2-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helix-hairpin-helix DNA-binding motif class 1" evidence="2">
        <location>
            <begin position="61"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="Helix-hairpin-helix DNA-binding motif class 1" evidence="2">
        <location>
            <begin position="91"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="Helix-hairpin-helix DNA-binding motif class 1" evidence="2">
        <location>
            <begin position="177"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00015260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5106713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="494" mass="55072" checksum="9F08B4278DF22C3C" modified="2022-05-25" version="1">MGQSSSLHSGAKSRRSSLKQITLAGFGRRRFQNSKNLSHTFSVLDDTLKPQLLNLNTATEEELMTLPGINRHLAANIVNYRRVIGRFNRVEDLALVSGIGADKLESIKMEVYVLTGNDSGTSSRASTSLNSVGNNTNQVDVNLASVFDLQVVPGVDQELASRIVEKRLKYGCFNSLDELAKMRGMGKQKLAMLRPYLKLSSISNGSAVHTCSNGSPSSSWNIPQASKEEIWELLSIASPRPCIEYNFNESLDRTSIRVASWNLNGFNSDKASNPGVMEVICRTILENRLSLLALQEVKSLEALDKLTRELNTPVLKRVKDWRGNHRQWRSVHLGAGLAVLWDACPDMSISLREQPPATTVFLPVLASIIFHVNKFDITLINVQMHDPEDNNIIERFVDAKNSIFLGDFSLSGDTSNIYNDVLSETNTAFDTEKYIFKDKIVWGRGSKKLFNTGLYRVVRQGLTHLGIPQCWRWGGPASTHCPIWCEIYTEPGDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HQH5</accession>
    <name>A0A8J2HQH5_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS13094</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5108151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HQH5"/>
    <dbReference type="OrthoDB" id="7699669at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5108151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="370" mass="42412" checksum="6FE1E651FC9D48C5" modified="2022-05-25" version="1" fragment="single">TIIKTRVAPQTNPRIKFKPDLTKAQQNHLTSLRAELKSLHERGDKNKTINGGVFIAAKLALQADQIYLEEDILEQVFIKIKGIKNDLITGCIYIPPMSTIDIYEQHFNALIFIRNKYKETSFLIVGDYNLPSSQPSPVCTKFITESLALIECYQHNTVLNDTNTILDLCFSNLDPSINRASALTTEEKCHPALAVTIDYNLKLKLLSSPSYIYSKADYTELNNFFFNTNWTNLYQLDNLDDKLIPSDPITSLSGSQRSLFNLLNKKKNAHCEYKINKSYINYRRFSDLRRKSKLLGISCFNVYLGRVEKSIHQDTKKFWNFIKNKTHDNSNIPSAMSWNDFSAHTGPEISELFASFFKENHAPESIRTLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HQK7</accession>
    <name>A0A8J2HQK7_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Similar to scrib: Protein lap4 (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS13688</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5109052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HQK7"/>
    <dbReference type="OrthoDB" id="2187496at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005912">
        <property type="term" value="C:adherens junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016323">
        <property type="term" value="C:basolateral plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0014069">
        <property type="term" value="C:postsynaptic density"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045211">
        <property type="term" value="C:postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098609">
        <property type="term" value="P:cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045197">
        <property type="term" value="P:establishment or maintenance of epithelial cell apical/basal polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098968">
        <property type="term" value="P:neurotransmitter receptor transport postsynaptic membrane to endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098887">
        <property type="term" value="P:neurotransmitter receptor transport, endosome to postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043113">
        <property type="term" value="P:receptor clustering"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050614">
        <property type="entry name" value="Synaptic_Scaffolding_LAP-MAGUK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23119">
        <property type="entry name" value="DISCS LARGE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23119:SF44">
        <property type="entry name" value="PROTEIN LAP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52075">
        <property type="entry name" value="Outer arm dynein light chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5109052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="97" mass="11604" checksum="72E72E16395AE51A" modified="2022-05-25" version="1">MFRCIPIFKGCNRQVEYVDKRHCSLPSVPEDILRYSRSLEELLLDANHIRDLPKNFFRLQRLRKLGLSDNEIRRLPPDIQNFENLVEFDISRNDFGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HR10</accession>
    <name>A0A8J2HR10_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS13290</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5108544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HR10"/>
    <dbReference type="OrthoDB" id="6340140at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035300033" evidence="2">
        <location>
            <begin position="34"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="63"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5108544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="155" mass="17859" checksum="D2A81AC53F3D26EF" modified="2022-05-25" version="1">MIFQIMKQSRGKSCWRFLGILLFSIAALETVWAAPVPEPGMVYSDPFPDDTENYVWLQKLKQIHDIKLEISEDERELSDAQLEIQAMLEANARNQRVPHYPIPPEFLSEDPEALPVPEPRVNPGPTHSGKRTSYMALCHFKICNMGRKRQLPEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HR15</accession>
    <name>A0A8J2HR15_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to loco: Regulator of G-protein signaling loco (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS14022</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001320">
        <property type="protein sequence ID" value="CAG5109386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HR15"/>
    <dbReference type="OrthoDB" id="10266999at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008277">
        <property type="term" value="P:regulation of G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.196.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.167.10">
        <property type="entry name" value="Regulator of G-protein Signalling 4, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016137">
        <property type="entry name" value="RGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046995">
        <property type="entry name" value="RGS10/12/14-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036305">
        <property type="entry name" value="RGS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024066">
        <property type="entry name" value="RGS_subdom1/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044926">
        <property type="entry name" value="RGS_subdomain_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45945">
        <property type="entry name" value="REGULATOR OF G-PROTEIN SIGNALING LOCO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45945:SF3">
        <property type="entry name" value="REGULATOR OF G-PROTEIN SIGNALING LOCO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00615">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01301">
        <property type="entry name" value="RGSPROTEIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00315">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48097">
        <property type="entry name" value="Regulator of G-protein signaling, RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50132">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RGS" evidence="2">
        <location>
            <begin position="26"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5109386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="116" mass="13312" checksum="3DDB11AFE4857B24" modified="2022-05-25" version="1" fragment="single">MLQQYGSTDSCDKEDNNYGVHTWASGFEKLLKDPVGLQTFAEFLKKEFSHENIYFWAACERYKNTDDTSNRRTLAWKIYERHLSATAGEPVNVDSHAAGQITQELINYAPADLFLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HRF2</accession>
    <name>A0A8J2HRF2_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS13926</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5109290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HRF2"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5109290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="80" mass="8944" checksum="F742601D1C61229B" modified="2022-05-25" version="1">MLKEALDVYHENIQKTLQELFNRPSTSSANTERSSTKSTAKSPSVDTQSGEKMKELGVPGTTLKEYFPKQFRDGDFGKSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HRJ3</accession>
    <name>A0A8J2HRJ3_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Similar to slc39a13: Zinc transporter ZIP13 (Danio rerio)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HICCMSTLAB_LOCUS13077</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the ZIP transporter (TC 2.A.5) family. KE4/Catsup subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5108117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HRJ3"/>
    <dbReference type="OrthoDB" id="200954at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005385">
        <property type="term" value="F:zinc ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006882">
        <property type="term" value="P:intracellular zinc ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003689">
        <property type="entry name" value="ZIP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16950">
        <property type="entry name" value="ZINC TRANSPORTER SLC39A7 HISTIDINE-RICH MEMBRANE PROTEIN KE4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16950:SF16">
        <property type="entry name" value="ZINC TRANSPORTER ZIP13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02535">
        <property type="entry name" value="Zip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="38"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="79"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="112"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="352"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="379"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="413"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAG5108117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="431" mass="47003" checksum="9B68CCEEB1852628" modified="2022-05-25" version="1">MIECKDNSTSMDALYQIVTNEIWESWNNVTDYFEYQPWIFSLLGSAMVGLSGVFPLFIIPIDEGADLKHGPGAKTLKMLLSFAVGGLLGDVFLHLLPEAWENKSLNSNSTNGHPSMVCGLWVLTGFLVFIIAEKLFLGADEQEIDEDQDIDWVKAKNQECDGVYNNCGTDNNNCLAVNGKIEVNKTLLTNVDSTFSEKNDYDSLISVNLKTNGIKPNVYSELHDKSDMQRKKLIDSVKSNKLLNKIVKNNIIKTAVSADNVSNNLTLNGKIPDKLTVKEKSKHISGYLNLLANCIDNFTHGLAVGGSFLVSFRLGALTTFAILIHEIPHEVGDFAILLKSGFNKWDAARAQLITATGGIFGALIAVLCSGSGVESRTSWILPFTAGGFLHIGLVTILPELLKESNPIESCKQLGALLSGISIMAILTIICD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HSL4</accession>
    <name>A0A8J2HSL4_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Similar to KIF16B: Kinesin-like protein KIF16B (Homo sapiens)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HICCMSTLAB_LOCUS12571</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5107071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3176171at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47117">
        <property type="entry name" value="STAR-RELATED LIPID TRANSFER PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47117:SF1">
        <property type="entry name" value="STAR-RELATED LIPID TRANSFER PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0505">Motor protein</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="6">
        <location>
            <begin position="3"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="163"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="641"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="712"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="613"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="102"/>
            <end position="109"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAG5107071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="1744" mass="196174" checksum="9E77F6496CE74925" modified="2022-05-25" version="1">MANIKVAVRVRPISSREINITGAEIVVHTEPQKISLTNLKVSSSKTADSRTRTKRYSFNYCFDSSDPTAENYASQEKIYYTLGNPVIDAIFVGYNSCVVAYGQSASGKTFTMMGVKDDPGLIPRICNGLFVRAADEIENGKKFNIFVSYLEVYNERVRDLLEPSTSPNNLRVREHPRSGPYVQGLSQHSVETLSSLMSRVEEGTKARKTASTLQNHTSSRSHALLTLSLESSDSAVSGQVILKASGASRKTDFSRGCKLHLVDLAGSENSAACAGINRLKSQEGANINKSLVALGNVISALAERSSTTINSGRKFIPYRDSTLTWLLKDSLGGNATTIMLATISPASGSYNETSHTLRFAQRAQSVINKPVINEDPVAKIIRELHFDDGLRLRCDSLNALRQFGSLEFVPAANNSKTLRVSASYNRARVSKLTDEDDDDKVDEPVFVDIPTLVAVLIKPDTSVQVDTHQIEEISSDSALEDTVDTEFNRDIEHHFANLVNVPVENDSNDSIKSLPILKENEQPPLDTRYPNLQILTDKSLNDDDKFQKQYSVSSNFEAQVSLEKSISNTADNVPQDSGVLQISTIDSEAQADFEVEEPKKIIRIEDDNLNDSLKEDNEIVNKILENRKELQNQKLCLQRHQNTDGLKRKSSKDSSCNSSKDEQIFISGISRDSFGRKDSIDPEQPQPRPHTIIQRARRADIVAAVTERLYSSKKTTEDSNTASTPTLDIRSPESTEVKLASVTRMRLQEISRKMLAKRRRICVDTQTDISSTVRVREIGISVKEPKVVRKDVAVLTDRHEDFDKLLPCSTPVVRIKEMSTSTTESPVPKPIILLKDACSLTDDYSYDYDTIYSLQPDSGIVSDDTHTYAESNLSSTGISDFCSDLEKRPVDVKLSDSSANTNIVEEIIDSCAQTTYEHSHHYEVPNDKCCTSKQCGDNSIKQVSGKKTADCCRPISVTPRPCKPPVVTAGHCHSTETVADTHKCAQESSCKSSCYKEDHDKNIISISVPDTINITIESSNISESKLRLFDHNKVLKLNNAEVQTDKRDSNEIGTLTDINISGISVKDSWTNARNSHDTKTFRIENIFKDPHDIAKSSKSYDYSDGTNYSIIYPRTTQFTETKTKNDAYDSYKTTLSSLESRRKSLTSEWLRNRNTWSSQKYHRSFDNENNTETISLPSENSYDSIVIKQLKENPEILSWKDVCEDKKSLNGLTVSECLKSDDNPCYIKKIGRSYRDIYEQEVNFSDDSLDSKERQKNLIDDEITESEMNSRIKDNFNDNGCQPDIVVHAKKEIIDPLAFSDNNTLDDFDDKYIELPKKIGIRLNEIPRQRIKSIFYSVPLIPLVLAENGIEQSEDSTKNLKATASPKSIIKNNINVPKTPRSVNISTNESRLESDYKKVSFVESENFSINSEDVKQKTTRIKNSCEEEKRNLLEEYLEEAIVFMRNINSINSDEKSGTLTFRRENNVETKIYEPKNKRVIDHRYTTDDLDLKDSRYEEKCCGNSGKLDRLLKFNKSAETKSHLAKFSSDNVNSSNSWSSCSRLRSFSSVDDLNWDHKLKNNVYSRSDCNSKFSQVIEDDKYFYQLHSAGANKVYTNIDSARAVNTDFESYSQGRIRSSAPKIKKRSRSELSMRPKTGDCSFSKKVVTFDENTLHTHKKLMNNESALIAKGRKSLANPRCSLSKYDSSNENSSSNEALANFMESIDEASRFKDKIKFPCSPRLKFLQLLSERQKIVKDSRNTSIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MBJ5</accession>
    <name>A0A8J2MBJ5_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Large ribosomal subunit protein bL21m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS2728</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bL21 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001117">
        <property type="protein sequence ID" value="CAG5078404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MBJ5"/>
    <dbReference type="OrthoDB" id="5994at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028909">
        <property type="entry name" value="bL21-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036164">
        <property type="entry name" value="bL21-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21349">
        <property type="entry name" value="50S RIBOSOMAL PROTEIN L21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21349:SF0">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN BL21M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00829">
        <property type="entry name" value="Ribosomal_L21p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141091">
        <property type="entry name" value="L21p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00044129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5078404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="218" mass="25261" checksum="A79FA47FDBB21740" modified="2022-05-25" version="1">MALFIRLPRVFNVINNCLNKQLPINNTCIVRHVGGYRGLFNNLPKKPVRKLSLPWIYKDRSQPMEIPEPTQQEEQMEKSVIEEINNQVLSKNTSRLFAIIVLAGKQFKVTENDLIVIQGYWPPNPGDKLRLEKVLLVGGMDFTLVGRPLLNRELVGVDATVVDKTFSHTKYEFRYLPRKQFKRLHMMRSQLTTLRINSIDIKGAVDEKKEVEGLDRVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MFE8</accession>
    <name>A0A8J2MFE8_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific protein-tyrosine kinase</fullName>
            <ecNumber evidence="2">2.7.10.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">HICCMSTLAB_LOCUS4715</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.10.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 19">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.10.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.10.2" evidence="2"/>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5088111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MFE8"/>
    <dbReference type="OrthoDB" id="1915767at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005126">
        <property type="term" value="F:cytokine receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004715">
        <property type="term" value="F:non-membrane spanning protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004714">
        <property type="term" value="F:transmembrane receptor protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009887">
        <property type="term" value="P:animal organ morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048468">
        <property type="term" value="P:cell development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007259">
        <property type="term" value="P:cell surface receptor signaling pathway via JAK-STAT"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019221">
        <property type="term" value="P:cytokine-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002009">
        <property type="term" value="P:morphogenesis of an epithelium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030182">
        <property type="term" value="P:neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051130">
        <property type="term" value="P:positive regulation of cellular component organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050793">
        <property type="term" value="P:regulation of developmental process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd14473">
        <property type="entry name" value="FERM_B-lobe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00192">
        <property type="entry name" value="PTKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:001512">
        <property type="entry name" value="Receptor tyrosine-protein kinase erbB-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019749">
        <property type="entry name" value="Band_41_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019748">
        <property type="entry name" value="FERM_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000299">
        <property type="entry name" value="FERM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041155">
        <property type="entry name" value="FERM_F1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051286">
        <property type="entry name" value="JAK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000980">
        <property type="entry name" value="SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45807">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE HOPSCOTCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45807:SF7">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE HOPSCOTCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18379">
        <property type="entry name" value="FERM_F1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21990">
        <property type="entry name" value="SH2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00295">
        <property type="entry name" value="B41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55550">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50057">
        <property type="entry name" value="FERM_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0727">SH2 domain</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="11" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="domain" description="FERM" evidence="16">
        <location>
            <begin position="5"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="15">
        <location>
            <begin position="467"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="15">
        <location>
            <begin position="864"/>
            <end position="1142"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="900"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00051243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00051245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CAG5088111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="1142" mass="129437" checksum="224E7ABED98DDA49" modified="2022-05-25" version="1">MEEERSVTIYLATEIKFLNVPYLAEWTVEDICIAICKQLEIGPLARHLFALRGKSNKLWIPAGHKLETHEKNKFEFRLRFKPSSLKRLKLIDSNAYNYYFHQVRCDVLENKVADIVYEKHKRELIGLGVSDMYRVIVEKQIPREVVEGDYKKYIPKECIKRHSFFIKKPIHNALARISGHDAAYVKEQYLNQFEVMAPNYPYEEYKALMDKNLPDPASRILLRVNPSEVMYYELDVHNQWTTLCAIEDLCSISIGQDNTVEVSRKSGIPSYLKFSTNALLMSFVSALDGYYRLAVKWTFNLCRDIITPSLEKLHKMKCHGPVGGEFSYAKLKEKRSNKSGTYILRECEKKYNVFWLDSCGKDHKPRTYKIEQLGPESFIISESVQTYKSITHIVSSFNDSEQTLYLSECLPPSEYDKSPLLICAMTEVCNDVAADEEIITALLEGEPRVIPSHQLQIYKANPFPEKNSKTVTIGQGSFTSVYRAMWRVTKGKKLEAAIKVLRDEKSRYAREFFELAGKWGQLRSSALVRLYGLTVSPTVGMLMELIKLGPLDVYLQSKSAQSIKTVDMVEASACLANALWHLEENGFVHGNIRCRKLLVHVHSDTSFIIKLANPGLFFYTQADIHWLPPETYDNPEEARRSTRADVWALGTTLWQIFSRGAALPVNRDIDSIKRFYLSGKRLPIPAGCPAEVYKLMTECWGDLSRPRKQPQAIMRDIHQILYQIYHSRRSHAYATVFPKSFSDRELTDESEIIDNSSSDCESRASSIFTDRTSLPWDDPDDSAAKLIQFNDTDNDAEEELSLYLGRLAGVGGIGDGGAGDNLGFSCLRDATVDLVNSLNESSGHNGGPLGQMQGIFELDADCNVILQGKIGQGFYGEVFRGILERDNAKDIEPQLVAVKKLKTRAVEADLRDFEREISIMKTLNHPNVVKILGVISEPEVCLVMEFVKHGSLQSYLAIHRENLTHKRLLEIALNISTGMDYLGRQSIVHRDLAARNILVSDDSTVKISDFGLAQVTGSNDYYILQTNRDLPIKWYAPESLRDGKFSPRSDVWSFGVTMYETFGLGEDPKLPGVGGQQGGDSAEEGGAALLAALERGTRLPCPQNCPQIVYVKLMYPCWHLQSHLRPDFAMLCNEIRDLITQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MGA2</accession>
    <name>A0A8J2MGA2_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Cyclin-dependent kinase 20</fullName>
            <ecNumber evidence="1">2.7.11.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Cell cycle-related kinase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Cell division protein kinase 20</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">HICCMSTLAB_LOCUS3031</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.22" evidence="1"/>
    <dbReference type="EMBL" id="CAJNRD030001117">
        <property type="protein sequence ID" value="CAG5079515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MGA2"/>
    <dbReference type="OrthoDB" id="7201987at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004693">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000579">
        <property type="entry name" value="cyclin-dependent kinase 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF171">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="4"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="33"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035711"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00035720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00035723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CAG5079515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="81" mass="9264" checksum="9D1589D6AF975A1E" modified="2022-05-25" version="1">MEDYTITGRIGEGAHGLVLRGIHCETGKHVALKRIMMKKIEDEIPVSIIREIKSLQELNHPYIIKLLDAFPSGYDFIMLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MGH3</accession>
    <name>A0A8J2MGH3_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Ionotropic Receptor 76b</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">HICCMSTLAB_LOCUS2745</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001117">
        <property type="protein sequence ID" value="CAG5078455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MGH3"/>
    <dbReference type="OrthoDB" id="5984008at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015276">
        <property type="term" value="F:ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050906">
        <property type="term" value="P:detection of stimulus involved in sensory perception"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019594">
        <property type="entry name" value="Glu/Gly-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052192">
        <property type="entry name" value="Insect_Ionotropic_Sensory_Rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001320">
        <property type="entry name" value="Iontro_rcpt_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42643">
        <property type="entry name" value="IONOTROPIC RECEPTOR 20A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42643:SF24">
        <property type="entry name" value="IONOTROPIC RECEPTOR 60A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00060">
        <property type="entry name" value="Lig_chan"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10613">
        <property type="entry name" value="Lig_chan-Glu_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0407">Ion channel</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="8 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 16" id="KW-0675">Receptor</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="177"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="209"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="246"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="446"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="domain" description="Ionotropic glutamate receptor L-glutamate and glycine-binding" evidence="15">
        <location>
            <begin position="58"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="Ionotropic glutamate receptor C-terminal" evidence="14">
        <location>
            <begin position="176"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="16">
        <location>
            <position position="575"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF10613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CAG5078455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="575" mass="66399" checksum="AEBEF8D6F934CC59" modified="2022-05-25" version="1" fragment="single">MMGLELMLAGIYALTSNNSLNYTLDHRYRWEVSLDDVVSWNHNKTKEAEHYYDALPEELLVTTWDEGPYSSYNNINGKIIGGGYAFQIFDIIAKKLNFKYRIIPPEDLTIGNNETGMISMLNQSKVDMAVAFIPIIPEYMNFVEFSPILDSLEVSVLMERPLQSAIGSGLLAPFSKTVWICIFVSLALVGPIIYFVTSFRTWLWDRTNQDMYSFIDCVWFAYGAILKQGSAITPEADSNRLLFASWWIFITIITAFYTANLTAFLTLSEFTLEFTSVKDIYNLRKSWTAQRHYIIDITVNRNDPGELEPLKKSLNKTRGMFYNITKEDNKARKVAGFVTNDRLFIDEVQFVEDFIYRDYLNRTRLNMIEKEKCYYIKMPNSVYEQNRGFAYPLNSRIKKIIDRQLLHLVETGIIKHIESVNRPMVTYCPLDLGSTERRLENRDFKLTYEVVATGFLLALICFIVEVSQHYFKCRVCLCCADSCTCCKTRMKMQVSPAKRPQLPLPPLPITKEPIKTEFSAFSQPQIPIYDSIDNVISSKTRFINGRDYFVIKGVTGEKRLVPVRTPSALLFQYTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MGR3</accession>
    <name>A0A8J2MGR3_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Similar to Rdl: Gamma-aminobutyric acid receptor subunit beta (Musca domestica)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HICCMSTLAB_LOCUS3323</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5081571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MGR3"/>
    <dbReference type="OrthoDB" id="8890589at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005254">
        <property type="term" value="F:chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005230">
        <property type="term" value="F:extracellular ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099095">
        <property type="term" value="F:ligand-gated monoatomic anion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19049">
        <property type="entry name" value="LGIC_TM_anion"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.390:FF:000033">
        <property type="entry name" value="Gamma-aminobutyric acid receptor subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.390">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006028">
        <property type="entry name" value="GABAA/Glycine_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036719">
        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038050">
        <property type="entry name" value="Neuro_actylchol_rec"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006029">
        <property type="entry name" value="Neurotrans-gated_channel_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18945">
        <property type="entry name" value="NEUROTRANSMITTER GATED ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02932">
        <property type="entry name" value="Neur_chan_memb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00253">
        <property type="entry name" value="GABAARECEPTR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90112">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane pore"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0675">Receptor</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="29"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="59"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="92"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="216"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel transmembrane" evidence="3">
        <location>
            <begin position="33"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="164"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG5081571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="251" mass="27973" checksum="740C5059DDF6D6D2" modified="2022-05-25" version="1">MSNDLSVKNGGNYSRLACEIQFVRSMGYYLIQIYIPSGLIVIISWVSFWLNRNATPARVALGVTTVLTMTTLMSSTNAALPKISYVKSIDVYLGTCFVMVFASLLEYATVGYMAKRIQMRKNRFQKIAESMKAARENPGPPGVPGDHGDHAPKQTEVRFKVHDPKAHSKGGTLENTINGRADEEAPPAPPHLIHPTKDISKLYGITPSDIDKYSRIVFPVCFVCFNLMYWIIYLHISDVVADDLVLLEEAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MGZ8</accession>
    <name>A0A8J2MGZ8_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial</fullName>
            <ecNumber evidence="6">2.1.1.201</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Ubiquinone biosynthesis methyltransferase COQ5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">coq5</name>
        <name evidence="7" type="ORF">HICCMSTLAB_LOCUS3017</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Methyltransferase required for the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a 2-methoxy-6-(all-trans-polyprenyl)benzene-1,4-diol + S-adenosyl-L-methionine = a 5-methoxy-2-methyl-3-(all-trans-polyprenyl)benzene-1,4-diol + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:28286"/>
            <dbReference type="Rhea" id="RHEA-COMP:10858"/>
            <dbReference type="Rhea" id="RHEA-COMP:10859"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:84166"/>
            <dbReference type="ChEBI" id="CHEBI:84167"/>
            <dbReference type="EC" id="2.1.1.201"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="6">Cofactor biosynthesis; ubiquinone biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9. Interacts with PYURF; the interaction is direct, stabilizes COQ5 protein and associates PYURF with COQ enzyme complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Mitochondrion inner membrane</location>
            <topology evidence="6">Peripheral membrane protein</topology>
            <orientation evidence="6">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the class I-like SAM-binding methyltransferase superfamily. MenG/UbiE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.201" evidence="6"/>
    <dbReference type="EMBL" id="CAJNRD030001117">
        <property type="protein sequence ID" value="CAG5079460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MGZ8"/>
    <dbReference type="OrthoDB" id="6329284at2759"/>
    <dbReference type="UniPathway" id="UPA00232"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031314">
        <property type="term" value="C:extrinsic component of mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008425">
        <property type="term" value="F:2-methoxy-6-polyprenyl-1,4-benzoquinol methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000064">
        <property type="entry name" value="2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01813">
        <property type="entry name" value="MenG_UbiE_methyltr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004033">
        <property type="entry name" value="UbiE/COQ5_MeTrFase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023576">
        <property type="entry name" value="UbiE/COQ5_MeTrFase_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01934">
        <property type="entry name" value="MenG_MenH_UbiE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF24">
        <property type="entry name" value="2-METHOXY-6-POLYPRENYL-1,4-BENZOQUINOL METHYLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01209">
        <property type="entry name" value="Ubie_methyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51608">
        <property type="entry name" value="SAM_MT_UBIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01183">
        <property type="entry name" value="UBIE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="1 6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 6" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 6" id="KW-0831">Ubiquinone biosynthesis</keyword>
    <feature type="binding site" evidence="6">
        <location>
            <position position="65"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="125"/>
            <end position="126"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00046387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAG5079460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="239" mass="27233" checksum="61D9E4E8B3473D3E" modified="2022-05-25" version="1">MMSQQLILGLKQLKNVIKVNKKVADSYDVMNDAMSFGVHRIWKDLFIQELSPSHGCKLLDTAGGTGDITFRYLNYLNNLENKKKIKSYVTVSDINQNMLDVGQSRAKKLGFTPEIGYNIDWLQSDAESLSCPDESYTAYTIAFGIRNVTHIDKVLSEAYRVLQPGGRFLLYDQYSFQMIPVMGKLIAGQWEPYQYLVESIRKFPKQDELKGMIEDAGFRQVTYKNLTFGVVAIHSGFKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MIL9</accession>
    <name>A0A8J2MIL9_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Similar to PSMD12: 26S proteasome non-ATPase regulatory subunit 12 (Homo sapiens)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HICCMSTLAB_LOCUS6970</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the proteasome subunit p55 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5093634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MIL9"/>
    <dbReference type="OrthoDB" id="268763at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008541">
        <property type="term" value="C:proteasome regulatory particle, lid subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000070">
        <property type="entry name" value="26S proteasome non-ATPase regulatory subunit 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054559">
        <property type="entry name" value="PSMD12-CSN4-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040134">
        <property type="entry name" value="PSMD12/CSN4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040896">
        <property type="entry name" value="RPN5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10855:SF1">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10855">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 12/COP9 SIGNALOSOME COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22241">
        <property type="entry name" value="PSMD12-CSN4_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18098">
        <property type="entry name" value="RPN5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0647">Proteasome</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="3">
        <location>
            <begin position="244"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG5093634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="453" mass="51815" checksum="35C3274510D6AB09" modified="2022-05-25" version="1">MTDPTTTDSGRIVKMEVDYSSNCDVKIPECKKLAQEGKLHDALDQLLILEKLTRTGADMISTSRVLVAIVEICFEAKNWAALNEHIVLLSKRRSQLKQAVTKMVQECSTYIDKTPDKQTEIKLIETLTSVTAGKIYVEVERARLIHRLAKLKEEDNDITGAASIMLELQIETYGSMAKREKAALILEQMRLCLAKQDFVRTQIIAKKISIKFFEDENNEETQALKLKYYELMMELAKHEGWYLELCRHNRAILETPTVKNDSEKRHTALSRAVLYLVLASHEPEQADLTHRLLADKLIDEIPTYKELLRLFVNPELIKWSGLCDIYEQELRTTEVFTASTEEGRKRWTELRNRVVEHNIRIMAKYYTKITLTRMAELLDLPIEETETCLCKLVETGVISARTDRPAGVVRFTGTQEPAAVLDAWAASLNKLMSLLNHTTHLIHQEEMLAVANA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MIU3</accession>
    <name>A0A8J2MIU3_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS7105</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5093779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MIU3"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035150216" evidence="1">
        <location>
            <begin position="27"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5093779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="119" mass="14464" checksum="4FBB1EBBDDA9AC03" modified="2022-05-25" version="1">MFIVIAPPRLLFLLLFFFFDNENLIANGGVIRFLMRLFSLKIYDEILGKIWLESKLPIWLDLYHAFFPKKASIKINGRDFLNHEEINAKKFKHLYNYCKLIIVEHMIRIMYMYTYDHKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MIW1</accession>
    <name>A0A8J2MIW1_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Olfactory receptor 66</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HICCMSTLAB_LOCUS7150</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5093824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MIW1"/>
    <dbReference type="OrthoDB" id="7486936at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005549">
        <property type="term" value="F:odorant binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004984">
        <property type="term" value="F:olfactory receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004117">
        <property type="entry name" value="7tm6_olfct_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21137">
        <property type="entry name" value="ODORANT RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21137:SF35">
        <property type="entry name" value="ODORANT RECEPTOR 19A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02949">
        <property type="entry name" value="7tm_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0552">Olfaction</keyword>
    <keyword evidence="8 11" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="9" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="33"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="71"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="127"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="186"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="297"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAG5093824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="390" mass="45566" checksum="5483D888FC335C3B" modified="2022-05-25" version="1" fragment="single">MDVQHAIKYTQWFMELLAIPHRYKRKFSTKKKLSSAVGLFVINVLIVWNISFRSIDMFTVVRDFDEKILLFAPWSFSVVINIKYMFMIFRGNDIMMIIEHIKIDWIEKKSPEEELIMVRNSQLCNRITLCFMVLMYVSGALYNFVIPFVLPILLHSKSNTSDRTPIFDGYDVFFNAQVSPIYEITFFFQVYVVTIGFSILIFMCHLTVVSVTHACGQIQIINYLIRYLIDDIIDINNIQNKISIIISRHIRVLSFVENVQKILLELCLLEMGASTVLICIDEYCFLKMLETNDIANMIPFGMLFVCLNFNILVLCYFSELLNSQFIEIGTESSMTEWYRFPQKIKSYLILIICMSQRSQKLTAGGIIDLSYGTYIQILKTGFTYFQMLRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MJK7</accession>
    <name>A0A8J2MJK7_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Proteasome subunit alpha type</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HICCMSTLAB_LOCUS7848</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="1">The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the peptidase T1A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5095718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MJK7"/>
    <dbReference type="OrthoDB" id="40134at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019773">
        <property type="term" value="C:proteasome core complex, alpha-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03751">
        <property type="entry name" value="proteasome_alpha_type_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000007">
        <property type="entry name" value="Proteasome subunit alpha type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050115">
        <property type="entry name" value="Proteasome_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023332">
        <property type="entry name" value="Proteasome_alpha-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000426">
        <property type="entry name" value="Proteasome_asu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11599">
        <property type="entry name" value="PROTEASOME SUBUNIT ALPHA/BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10584">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00948">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00388">
        <property type="entry name" value="PROTEASOME_ALPHA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51475">
        <property type="entry name" value="PROTEASOME_ALPHA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3 5 6" id="KW-0647">Proteasome</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proteasome alpha-type subunits" evidence="8">
        <location>
            <begin position="8"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="228"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="228"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="245"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS00388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAG5095718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="254" mass="27932" checksum="E1A97A2B8E1BA4F4" modified="2022-05-25" version="1">MSSIGTGYDLSASQFSPDGRVFQVEYAQKAVENSGTVISLRGKDGVVFAVEKLVTSKLYEAGANKRIFNIDEHIGMAVAGLISDARQIVETARSEAASYRAQYGVGIPVKYLNERVAMYMHAYTLYSAVRPYGCSVILSAREADGPTMYMIDPSGVSYGYFGCAVGKAKQSAKTEIEKLKLADMSCKELVKEAARIIYLVHDELKDKQFELEMSWVGAHTKGKHERIPHEIKAEAEAKARQAMAEDSDSDTEDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MJP1</accession>
    <name>A0A8J2MJP1_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS7923</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5095868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MJP1"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5095868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="148" mass="16328" checksum="772410AD4AA76277" modified="2022-05-25" version="1">MTDHQYEVEELVLIEEAEVVDFAVELVLIEEVAVVDFAVELVLIEKVAVVGFAVELVLIEEVAVVDFAVELVLIEEVAVVDFAVELVLIEEVAVVGFAVELVLIEKVEEVDFVVVLGPTGELEVVDSAEKLFEKFAVQKLVAELELFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MJP8</accession>
    <name>A0A8J2MJP8_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS2867</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001117">
        <property type="protein sequence ID" value="CAG5078877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MJP8"/>
    <dbReference type="OrthoDB" id="7553586at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="274"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="511"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="276"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="332"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="511"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="552"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="651"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="686"/>
            <end position="703"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5078877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="746" mass="81182" checksum="FAF1C626EEE4E4F3" modified="2022-05-25" version="1">METNNAMETIDTVINEVLSALEYPQQVSSTGDTYDLSHLITKFGPLLSPQPEDSFVDLLESIIQESSASPVVSERPSVESNPVSPKRSFWSKLFSKKSHDGVSLPSVGSGNDSSASEAALKTAEVEVESLEASGPADLTCLSALSRELNRKICVWSSGMSLKHESGAERSGESLNVQFHSQPEDVMGHWSLLGDSDPQEAESGLNDCLFNAIAAQTGIRPSELREATVARMKTNIRSVARRIQEIARQEACDRIVLMVGGARYVGRGPEDAARILDNSQRGQSHPNRYPGHPRGHASNPGATGPLDSAENYSQNPDAANCDDAPEDDVGYDSDTQSASSTVPAGNRLPVPENPDVGYASAGSAENSPTEQGARFPTRKRLPDDDPRKYWKAGFLSIKEQDYFAHLVLSSPEAQEAMKKLNEGTGSELVRVKPAALPCEAPMGANFTNGFMGRPNPISELVIILKHHLNKKSDPNHDVFVFTFYPRLKKLFKKPRPRKDRLTRLAEREAAAAAAAAGNQEAEQGESSVQESQGSQVSGREERGGHSYSSRGSYDQRGRGSYDQRGRGSFEQRGRGSFDQRGRGSFDRGRGSFDRGRGSWRGYQGPDRGGYQGPPSQRDGYQGPPSQRGGYQGPPSQRGGYQGPPSQRGGYQGSDQRGSYQSQQNWQGSQGPGGQPLRVDSQEFVPRSHQGSQQSWRGSQQGPGQPLRPDSQEFVPRSHQGSQQSWRGSHGSGYDPRGRGYRGRGYQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MK02</accession>
    <name>A0A8J2MK02_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 8">Protein N-terminal glutamine amidohydrolase</fullName>
            <ecNumber evidence="4 8">3.5.1.122</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Protein NH2-terminal glutamine deamidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HICCMSTLAB_LOCUS8224</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="1 8">Mediates the side-chain deamidation of N-terminal glutamine residues to glutamate, an important step in N-end rule pathway of protein degradation. Conversion of the resulting N-terminal glutamine to glutamate renders the protein susceptible to arginylation, polyubiquitination and degradation as specified by the N-end rule. Does not act on substrates with internal or C-terminal glutamine and does not act on non-glutamine residues in any position.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>N-terminal L-glutaminyl-[protein] + H2O = N-terminal L-glutamyl-[protein] + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:50680"/>
            <dbReference type="Rhea" id="RHEA-COMP:12668"/>
            <dbReference type="Rhea" id="RHEA-COMP:12777"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:64721"/>
            <dbReference type="ChEBI" id="CHEBI:64722"/>
            <dbReference type="EC" id="3.5.1.122"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3 8">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the NTAQ1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.122" evidence="4 8"/>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5096467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MK02"/>
    <dbReference type="OrthoDB" id="191192at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008418">
        <property type="term" value="F:protein-N-terminal asparagine amidohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070773">
        <property type="term" value="F:protein-N-terminal glutamine amidohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.620.10">
        <property type="entry name" value="Protein N-terminal glutamine amidohydrolase, alpha beta roll"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037132">
        <property type="entry name" value="N_Gln_amidohydro_ab_roll_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039733">
        <property type="entry name" value="NTAQ1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023128">
        <property type="entry name" value="Prot_N_Gln_amidohydro_ab_roll"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13035">
        <property type="entry name" value="PROTEIN N-TERMINAL GLUTAMINE AMIDOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13035:SF0">
        <property type="entry name" value="PROTEIN N-TERMINAL GLUTAMINE AMIDOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09764">
        <property type="entry name" value="Nt_Gln_amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein N-terminal glutamine amidohydrolase alpha beta roll" evidence="9">
        <location>
            <begin position="27"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00021247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU367082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF09764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAG5096467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="182" mass="21222" checksum="73ACC96A857CE5FD" modified="2022-05-25" version="1">MATEPRVSGNNTKPLVPLFPRAADCVYTSCYCEENVWKLCQDVATKHASELPHCYVVFISNNNRSVPLWRQREGKGDDKVIVWDYHAILIYAPDERAVVYDLDSALPFPTFFWKYATETFRSDEALRPEYHRRFRLVPAALFLQNFASNRNHMKRKDGTWIKTPPEYPPISTPSKIFNTLYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MKC7</accession>
    <name>A0A8J2MKC7_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">TAB2_IMDPathway_Cc</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HICCMSTLAB_LOCUS5957</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5092166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MKC7"/>
    <dbReference type="OrthoDB" id="6367910at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14362">
        <property type="entry name" value="CUE_TAB2_TAB3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.380">
        <property type="entry name" value="Zn-finger domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041911">
        <property type="entry name" value="TAB2/3_CUE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001876">
        <property type="entry name" value="Znf_RanBP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036443">
        <property type="entry name" value="Znf_RanBP2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46253:SF1">
        <property type="entry name" value="TAB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46253">
        <property type="entry name" value="TGF-BETA-ACTIVATED KINASE 1 AND MAP3K7-BINDING PROTEIN TAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00547">
        <property type="entry name" value="ZnF_RBZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90209">
        <property type="entry name" value="Ran binding protein zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01358">
        <property type="entry name" value="ZF_RANBP2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50199">
        <property type="entry name" value="ZF_RANBP2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RanBP2-type" evidence="7">
        <location>
            <begin position="534"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="64"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="190"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="417"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="143"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="201"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="243"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG5092166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="599" mass="66267" checksum="2BE0879B5096D101" modified="2022-05-25" version="1">MGDCHCSNIAIMQLFHELKQQFPGLPDHVVSQCIAQQLLTFNLMLQNSHDRETCTESLRLTQELRPSPGAFPPPAPDLNLQRGMSLPEDPQKTLQSLHQKPKQKAHRPVSLDIGPARSPLHAARRVLPPLPPISSSQTPGRPAPSSAPAAYSTRGFFDDSSASPDNFRNVRNLNSGFELNVNVACSPASNRDFRTVQSPKKRNEPDPNEVLSDHTRSYTSVSLTLRPPSSEPQAPIDIRSQGSSLTYSTSSLDPRGFQSRLQISIGPGNVGSVAAARIRPPMGTRPNNLIPVASGSHKPPGNVKFLSAELINLPRPTTTMSAPTTPSAPAVGIVSNPSSLPATPSGPVSSFPSSPYKDAISVDLSRLSLHQANFNLNSNHSFSFMYLFSKYNNLLIVYFFSVSENQKQLITEQLVRKERLSRELKIEKGRLEALKREIHAIQGPVYPIVSLEQRASDLRSEIYQLELECGLLTNEVDKSINPSVPLGETNEEFYNGIYRGQSINLPAFTSSPPPLPSVPLTWDPSQNIHEDEDKDGPSWICEKCTFNNHPLIDICEVCLMPRFKELEDTGTKNQTQDIHIRVTHHHNFSPRRTVHSWVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2ML28</accession>
    <name>A0A8J2ML28_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Cc_bv6.2_29.4_pseudo</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS6121</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5092407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2ML28"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5092407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="42" mass="4738" checksum="D7905E37885D203A" modified="2022-05-25" version="1">MSSSLEKTGLCTRKKVHIIPTEWASYPTQTLDCIVYSGVKEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MMY1</accession>
    <name>A0A8J2MMY1_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS9149</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5099617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MMY1"/>
    <dbReference type="OrthoDB" id="6339724at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006631">
        <property type="entry name" value="DM4_12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21398">
        <property type="entry name" value="AGAP007094-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21398:SF6">
        <property type="entry name" value="AGAP007094-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07841">
        <property type="entry name" value="DM4_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00718">
        <property type="entry name" value="DM4_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035283949" evidence="2">
        <location>
            <begin position="18"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="237"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="252"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5099617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="274" mass="31071" checksum="71AAC2DAEFD16E00" modified="2022-05-25" version="1">MLRFILIALLTSCRVNGNTDSTNEPHHRQKRVFWITNDGRIALPPGTILTITPTIALPFVRYPPHGFLSNMTISLPFTIDFDKLGLTDNENPYGALPPVFGRGMESRKAGMMMADFIASFIKRRLHKRDLEEAPPKNAFHGGERALLYVTAEEMLSTLGMDGKACLLRAICEVQGHPLSNFGLVGEMLKLFFTASKSPFAELLNEYVEAENRGKIHGECWPYYKNCPKSLFLPSTNRYTKDSNDIEEPNDENEIKDQKSDYDRQSQEYMINPSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MN52</accession>
    <name>A0A8J2MN52_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS8151</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5096320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MN52"/>
    <dbReference type="OrthoDB" id="6618165at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035239085" evidence="2">
        <location>
            <begin position="17"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="105"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5096320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="184" mass="20492" checksum="0F372425954A6F27" modified="2022-05-25" version="1">MYRTVIILVVISAVYGGPLEPTTQQPQFAEGTKIQQTPSLVTYEPLPLNNYYPAYPEYKPVQSDNTQLVPSTPSSSSYNWLSTIITSLVPIRSFALFYGARAFGYFFQFTALFVAGLAITTSLCIFTPVCSITFSGLNLDKKEVKQQVSELARAFMTQDNLDAATIFVHRAIQKYYQLQNAGAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MNJ6</accession>
    <name>A0A8J2MNJ6_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Integrator complex subunit 7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HICCMSTLAB_LOCUS7226</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the Integrator subunit 7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5093900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MNJ6"/>
    <dbReference type="OrthoDB" id="1921953at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032039">
        <property type="term" value="C:integrator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034472">
        <property type="term" value="P:snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033060">
        <property type="entry name" value="INTS7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054519">
        <property type="entry name" value="INTS7_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056517">
        <property type="entry name" value="INTS7_HB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056516">
        <property type="entry name" value="INTS7_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13322">
        <property type="entry name" value="C1ORF73 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13322:SF2">
        <property type="entry name" value="INTEGRATOR COMPLEX SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22965">
        <property type="entry name" value="INTS7_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24437">
        <property type="entry name" value="INTS7_HB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24436">
        <property type="entry name" value="INTS7_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrator complex subunit 7 N-terminal" evidence="8">
        <location>
            <begin position="26"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="domain" description="Integrator complex subunit 7 helical bundle" evidence="9">
        <location>
            <begin position="515"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="domain" description="Integrator complex subunit 7 C-terminal" evidence="7">
        <location>
            <begin position="788"/>
            <end position="927"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF22965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF24436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF24437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAG5093900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="949" mass="104310" checksum="B2263D52E4DEE367" modified="2022-05-25" version="1">MNSFSESGAGEPEQDANSALIELDKVRFPRLFEKYPFPILINSALLKLADVFRLGSNFLRVWVLRVCQQSEKHLDKILNVDEFVRRIYSVIHSNDPVARALTLRTLGSAAGIIPERQQVHHSIRKSLDSHDSVEVEAAIYAARMFAAQSKLFAVSMCSKISDMIRGQATPASMKLQLIPILQYMHHDTSTASMVNELCMELLVSYPAVEFVRVTLSAMSTLASATLIDVPNQVALLLKYLRDDPRLSVKRHALRLLLDLAKRGAHLWPRGALDNLVDSTTRLPQDNSESTDLLLRTLDVIEVLSRNAVTCDGNKDENSPLSSMCIDACYSHDPLIAVKAVMILSRIACYCYEENLPVSNIQHTISCLESLIVLLGTEDKYVHHLKMCLASTVKLCHAHFNHAPIFVDVIGSTLMNSSSEYSNSGKLSAVLCEALGAIGSLGNNVLLPLLPDILEKLKHMTDAHTKVMLCTLLFQVVAGGYEWNEECLKAIRTATKTVDGWAKYRIARGAARYGHHGIASEIFKNLKEAVASEQLHFWLSGLELLTSAESYLTSNQDESNAESKARITDKLNGAISRYASACASLKAASTPLKSLQFACEYAKLRCEFLQALAQLVHSCRSLCTSPPPAIAMSIVVLTKDDFQRYGRVTYQLRKSAQDFRNCADNYQKLYQSAFDADHGSLNNIRALKEICLLMATSVDRVCSPFNSATNQRSESEFSFGDSVEMRQLARCCVEVRRLGPTWQVQEKEEAISHSRIESLISQVMLLAGGKIRLPMPRYFFQALQATVVKLSVSPQPRVLGEPVCVPQGSQLALKIEGVLRHGKRSSLFRSVAAVCISISTTPPSKISADSKNGAAHETNGNELQQTVTPHRDFFACEFLLSLGSSGAGAGNNCAGPVPGTSTAGTSSSGTQFQVTASASILDKDGNVWKCGPRSTLQVRVHEDQTKRKLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MNN2</accession>
    <name>A0A8J2MNN2_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Similar to ASB7: Ankyrin repeat and SOCS box protein 7 (Pongo abelii)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HICCMSTLAB_LOCUS8968</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5097969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MNN2"/>
    <dbReference type="OrthoDB" id="6596655at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061629">
        <property type="term" value="F:RNA polymerase II-specific DNA-binding transcription factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24126:SF14">
        <property type="entry name" value="ANK_REP_REGION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24126">
        <property type="entry name" value="ANKYRIN REPEAT, PH AND SEC7 DOMAIN CONTAINING PROTEIN SECG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="210"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG5097969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="250" mass="28749" checksum="B3B1F9CB044AA8CB" modified="2022-05-25" version="1">MSTLMRNLKTAIFFGDVKKVKKLLKSLAPIPLSKNPLIFGGYSLLKLAIKLRNRKEIAKLLIKKGARVNKKYCDESVPLLHIAIRKQHPDIVKLLVKKEANKWSRCISNDKFITEEIEKYSYCTALDLSCIYQQLKMARLFLKLNDKPNSTPLFDSNSISIAVIRNLWKVVRLLLKYNAWANSTISKMTITHCSRYYSRVPQTRLNSLGENPTLLHAAIVKNNVKMVELLINHGANIHYRTKSFKRTPLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MP71</accession>
    <name>A0A8J2MP71_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Mitochondrial (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">HICCMSTLAB_LOCUS9226</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the MICU1 family. MICU1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5099771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MP71"/>
    <dbReference type="OrthoDB" id="10056860at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990246">
        <property type="term" value="C:uniplex complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036444">
        <property type="term" value="P:calcium import into the mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051560">
        <property type="term" value="P:mitochondrial calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15900">
        <property type="entry name" value="EFh_MICU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039800">
        <property type="entry name" value="MICU1/2/3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12294:SF1">
        <property type="entry name" value="CALCIUM UPTAKE PROTEIN 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12294">
        <property type="entry name" value="EF HAND DOMAIN FAMILY A1,A2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="EF-hand" evidence="15">
        <location>
            <begin position="213"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="99"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00038333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CAG5099771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="534" mass="62813" checksum="7AE333596F7CE3F4" modified="2022-05-25" version="1">MSVQSRYFTIGKNIIFTQLSANSRHRLLSQTYKSQDQVIQVRGFRNFGHGINSDLSKTRTAMLGILAIGITAPYVNWKWIFKQIKKAFTVDAAEMLMEENEENNNTSVEQADSEPKKKKKKQKVGFRDRKIIEYENRIRHYSTPDKVFRYFATLQVSITDTHHEVYMTPDDFLRSMTPGVKQPEGLGLDQYKRFDPKRWIDKFLRLHFLTDSPFKRHFEIAFRMFDFNGDGDVDSEEFSKVATLIRQQTSIGNRHRDHANTGNTFKGVNSALTTYFFGSNMDQKLTIEKFLDFQEQLQKEILSLEFERRNPDADGKITETDFTELLLAYAGYPENKRIKMIKRVKKQFKDNPQGVSKEDYLKFFHFLNNINDVDTALTFYHIAGASIDQATLKHVAHTVAHVELMDGQLSNREFVAVMKNRVLRGLEKPKDTGFVKLMQSMMKCAKNNLKNPRRRNSKEPVNDFYNNQNYFQDIFMEHSKPLELEFGHVFENPSKWEQRFEKNDIENKRFQGKVRWGNNDGNYGEHYWDLNHRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MQ79</accession>
    <name>A0A8J2MQ79_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similar to spop: Speckle-type POZ protein (Xenopus tropicalis)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS10285</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5101212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MQ79"/>
    <dbReference type="OrthoDB" id="10249567at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd14733">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.710.10:FF:000159">
        <property type="entry name" value="Speckle-type POZ protein B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24413">
        <property type="entry name" value="SPECKLE-TYPE POZ PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="133"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5101212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="305" mass="35023" checksum="A4D1DC862A59D40D" modified="2022-05-25" version="1">MFTHNFEEKKTGEASIKDITAGTFNKLLEYIYTGEVSDLNSFAEDLLKAADKYEILLLKEMCEISLCKTLNHDNAVRRMDLADMHDAPYLIDYIIKCIMRDPLKIIPAKGSYHYSNYQLVEDFKELYKTRAFSDMVINVGEEKLQAHRIILMTRSPVLASMFNQEMSEKKVNEVVITDISSDTFEKLLEYIYTDEVSDLEEDAAELLKAADKYQLASLKKRCKESLCKSLNPENALKMLDLADRFSAPYLMEYVTKCITADEAKIVESEEFKEYEKSNPSLGLRLFKELAVARTCCEAGIRYSTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MQY2</accession>
    <name>A0A8J2MQY2_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="4">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">HICCMSTLAB_LOCUS8223</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="4"/>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5096465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MQY2"/>
    <dbReference type="OrthoDB" id="8693905at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06609">
        <property type="entry name" value="STKc_MST3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000411">
        <property type="entry name" value="Probable Ste20-like kinase Don3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000092">
        <property type="entry name" value="Serine/threonine-protein kinase 24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046409">
        <property type="entry name" value="PDC10_dimerisation_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048288">
        <property type="entry name" value="PDCD10_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050629">
        <property type="entry name" value="STE20/SPS1-PAK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48012:SF10">
        <property type="entry name" value="FI20177P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48012">
        <property type="entry name" value="STERILE20-LIKE KINASE, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20929">
        <property type="entry name" value="PDCD10_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="17" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11 20" id="KW-0418">Kinase</keyword>
    <keyword evidence="13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="19">
        <location>
            <begin position="108"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="44"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="378"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="435"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="482"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="17">
        <location>
            <begin position="134"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="44"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="73"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="18">
        <location>
            <begin position="385"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="499"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="544"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="137"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="CAG5096465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="653" mass="74026" checksum="70F224A6588822C3" modified="2022-05-25" version="1">MRNSSEAQQTAVIAPPYLNGSAQFISGGYTDYVSRQSWNQYHVSQQHLHTQQQPKTGRGSRPFSHPPPPPIIQRNNYHNQKSNSLPRSHINSSGRCTTPSKVDPELIFTKQERIGKGSFGEVFKGIDNRTQQIVAIKIIDLEEAEDEIEDIQQEIMVLSQCDSPYVTKYYGSYLKGTKLWIIMEYLGGGSALDLMKAGSFEEMHIAVILREVLKGLDYLHSERKLHRDIKAANVLLSEMGDVKLADFGVAGQLTNTTSKRNTFVGTPFWMAPEVIKQSAYDSKADIWSLGITAIELAKGEPPNSELHPMRVLFLIPKNNPPQLTGNYTKQFKEFVEACLNKDPENRPTAKELLKFQFIRKAKKNSYLIDLIDRYKKWKSQRSEESETESENSDSEESKQDSDMDEPWIMTVKGPHGAKTSVMSTFEDQLSLLSHTPNHRSVGHSQQQVKAHANGSAKSPPKDSPINNYRNESRDLLRDVQMKHNTPSRPHEAAPPPPVDLRENKDSRESRDSRELKEIRDVRDRENNTREKRNSKSDVSTTPMTDHKSNEDKLRPRSSQEPKHSRSATLTTVIFPILSELQGKYQFSSRDNKSDNAVTRNGGSIDELRSAFELAERTSPGINEIFVKEIFKALLPANHSDSRLSMIMEKIALR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MSB2</accession>
    <name>A0A8J2MSB2_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to vhl-1: von Hippel-Lindau tumor suppressor homolog (Caenorhabditis elegans)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS12658</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the VHL family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5107256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MSB2"/>
    <dbReference type="OrthoDB" id="413400at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd05468">
        <property type="entry name" value="pVHL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.780:FF:000001">
        <property type="entry name" value="von Hippel-Lindau disease tumor suppressor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.750.10">
        <property type="entry name" value="von Hippel-Lindau disease tumour suppressor, alpha domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.780">
        <property type="entry name" value="von Hippel-Lindau disease tumour suppressor, beta domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037139">
        <property type="entry name" value="VHL_alpha_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024053">
        <property type="entry name" value="VHL_beta_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037140">
        <property type="entry name" value="VHL_beta_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036208">
        <property type="entry name" value="VHL_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022772">
        <property type="entry name" value="VHL_tumour_suppress_b/a_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01847">
        <property type="entry name" value="VHL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49468">
        <property type="entry name" value="VHL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="von Hippel-Lindau disease tumour suppressor beta" evidence="2">
        <location>
            <begin position="9"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5107256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="161" mass="18870" checksum="CD21447F11530BCE" modified="2022-05-25" version="1">MGTNEPEILRSIEDRHKAFVRFINTTPYPIDVLWINYHGQAVRYSILQPLGTLDINTFATHPWIFVEHETRDRFIAEGKDVFFPQPWFTRYLGMSRDQLPEHISRVEVHITLPIYSLRDISLRAIKRLLRHDLHAFSLDIPKSLQCELASMLPRKDTSGDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MTY1</accession>
    <name>A0A8J2MTY1_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">protein kinase C</fullName>
            <ecNumber evidence="2">2.7.11.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">HICCMSTLAB_LOCUS13023</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.13"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.13"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.13" evidence="2"/>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5108009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MTY1"/>
    <dbReference type="OrthoDB" id="63267at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004697">
        <property type="term" value="F:diacylglycerol-dependent serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007200">
        <property type="term" value="P:phospholipase C-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20835">
        <property type="entry name" value="C1_nPKC_epsilon-like_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20838">
        <property type="entry name" value="C1_nPKC_epsilon-like_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04014">
        <property type="entry name" value="C2_PKC_epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.20:FF:000063">
        <property type="entry name" value="Protein kinase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.20:FF:000003">
        <property type="entry name" value="Protein kinase C delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046349">
        <property type="entry name" value="C1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020454">
        <property type="entry name" value="DAG/PE-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002219">
        <property type="entry name" value="PKC_DAG/PE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017892">
        <property type="entry name" value="Pkinase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22968">
        <property type="entry name" value="PROTEIN KINASE C, MU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22968:SF26">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00130">
        <property type="entry name" value="C1_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00433">
        <property type="entry name" value="Pkinase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00008">
        <property type="entry name" value="DAGPEDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00109">
        <property type="entry name" value="C1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57889">
        <property type="entry name" value="Cysteine-rich domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00479">
        <property type="entry name" value="ZF_DAG_PE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50081">
        <property type="entry name" value="ZF_DAG_PE_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10 19" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="11" id="KW-0862">Zinc</keyword>
    <keyword evidence="9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2" evidence="16">
        <location>
            <begin position="1"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="17">
        <location>
            <begin position="188"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="17">
        <location>
            <begin position="266"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="18">
        <location>
            <begin position="328"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="132"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="337"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="144"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="161"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="346"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="CAG5108009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="410" mass="46192" checksum="D460B4843FFEF148" modified="2022-05-25" version="1">MFTGTVKVKICEASGLRATDKHRKFWQDAPPIIDPYVLLDVDQNRLNRTSIKAKTFDPVWNEAFTHDVQAAVMLGLTVFHDAALPPDDFVANCRIPFEELVRREDETADFWVDLEPHGKLRIKIDLKWSNQDQQPGCSSGEADGTGSVSGNVGSSAVTGDMEPRGFKERQGFNRRRGAMRRRVHQVNGHKFMATFLRQPTFCSHCRDFIWGVGKQGYQCQVCTCVVHKRCHKLVVTKCPGMRDEEMETVLQSNESIQGQRFSVNIPHRFEVHTFKRFTFCDHCGSLLYGLIKQGLQCQVCDLNVHKRCQKNVANNCGIDTKAMAEILSTLNISPEQQSKSRINYKPSSSSGGSSQSPSGNDAMNFDTEFTKEEPVLTPVHQSVLQSVNQDEFRGFSFVNRDFNTSKLGTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MWR5</accession>
    <name>A0A8J2MWR5_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glutamic acid- and leucine-rich protein 1 (Xenopus laevis)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HICCMSTLAB_LOCUS10675</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RIX1/PELP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5101774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MWR5"/>
    <dbReference type="OrthoDB" id="20900at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012583">
        <property type="entry name" value="RIX1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34105">
        <property type="entry name" value="PROLINE-, GLUTAMIC ACID- AND LEUCINE-RICH PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34105:SF1">
        <property type="entry name" value="PROLINE-, GLUTAMIC ACID- AND LEUCINE-RICH PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08167">
        <property type="entry name" value="RIX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pre-rRNA-processing protein RIX1 N-terminal" evidence="4">
        <location>
            <begin position="27"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAG5101774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="546" mass="61520" checksum="E750A72BD3B1E514" modified="2022-05-25" version="1">MAKVLDLINSVNDSVNKSKDFTINLLTTSSDLPFLITGVVILSKYLPRCSKDVLLKYGTFWISKVVQVLESNYEPGELSLACKVLGELLIVSKQIPELAKEISIHNIKPLAALITSFDINDKGTSLLYPLAILLHYYKESTEKFQTSIRELILPTIDSQSEEIVQAGANIFTLLTRATERSFKPIESKPSYTNWTYNLLLICNSLDEILDTLFNDKSNNSDEFKLKLPSVSEENVLDGCGESNSVIPNDILNLVERGFNISPSSLLKEDSVQNQILYIILPKLHVSLFNVLNAFIEGFKDNLVPFANEILPLYKHTLNWTNGSDNQTIGGKKPFTNVRLSAYKSLKVWMRNLNGLSGVEIICDDIIPWLLKDITPEKSQVLLTIKKTTATSKKAFKRTRDNQIKNDLTLDNSVGDKESIDVDLCKEALHCLQNIFKYSSLIKLPLYKVTEELIISLLYNVYMDSNNFYRQNPECHLQLLRTLKTMQMNPHPLGASSMHHCIELFSSASRENNLQVVEEAKEALMQLEKISHPSAPTLSLPVLSTTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MYK9</accession>
    <name>A0A8J2MYK9_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Kainate 1 (Mus musculus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HICCMSTLAB_LOCUS12990</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5107943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MYK9"/>
    <dbReference type="OrthoDB" id="5984008at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd06382">
        <property type="entry name" value="PBP1_iGluR_Kainate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2300:FF:000106">
        <property type="entry name" value="Glutamate receptor ionotropic, kainate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001828">
        <property type="entry name" value="ANF_lig-bd_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01094">
        <property type="entry name" value="ANF_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="Periplasmic binding protein-like I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Receptor ligand binding region" evidence="5">
        <location>
            <begin position="21"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAG5107943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="333" mass="38584" checksum="E01AA5495CBB0B93" modified="2022-05-25" version="1">MTVIFVLGAIFTDDQKDSPSELAFKYAIYRINKDKSLLPNTTLVYDIQYVPKDDSFRTSKKACKQLSRSVQGIFGPSDPLLGAHIQSICEALDVPHLEARMDFEPAFKEFSINLYPAQDHLNKAFKDLMSFLNWTKVAIIYEENYGLFKLQDLVKSPPSPRTEMYIRQAGAGTYRQVLREIRQKEIYKLIVDTDPAHMQFFFRAILQLQMNDHRYHYMFTTFDIETFDLEDFKYNNVNMTAFRLVDLEEPKVAEVLKQMERFQPIGHAILNRTGVIQAEPALVYDSVQVFAHGLASLDRSHVLRPMNLSCEKEEPWDDGLSLYNYINTVSTVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>S6CVT3</accession>
    <name>S6CVT3_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cc_ptp.alpha_17.4</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Protein tyrosine phosphatase PTPalpha</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">ptpalpha</name>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS1888</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Philos. Trans. R. Soc. Lond., B, Biol. Sci." volume="368" first="20130047" last="20130047">
            <title>Functional endogenous viral elements in the genome of the parasitoid wasp Cotesia congregata: insights into the evolutionary dynamics of bracoviruses.</title>
            <authorList>
                <person name="Bezier A."/>
                <person name="Louis F."/>
                <person name="Jancek S."/>
                <person name="Periquet G."/>
                <person name="Theze J."/>
                <person name="Gyapay G."/>
                <person name="Musset K."/>
                <person name="Lesobre J."/>
                <person name="Lenoble P."/>
                <person name="Dupuy C."/>
                <person name="Gundersen-Rindal D."/>
                <person name="Herniou E.A.Drezen.J.M."/>
            </authorList>
            <dbReference type="PubMed" id="23938757"/>
            <dbReference type="DOI" id="10.1098/rstb.2013.0047"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CAJNRD030001116">
        <property type="protein sequence ID" value="CAG5075841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="HF586474">
        <property type="protein sequence ID" value="CCQ71291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S6CVT3"/>
    <dbReference type="OrthoDB" id="7657559at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00047">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050348">
        <property type="entry name" value="Protein-Tyr_Phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000242">
        <property type="entry name" value="PTP_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19134:SF534">
        <property type="entry name" value="LD27988P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19134">
        <property type="entry name" value="RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00102">
        <property type="entry name" value="Y_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00700">
        <property type="entry name" value="PRTYPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00194">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50055">
        <property type="entry name" value="TYR_PHOSPHATASE_PTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5075841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCQ71291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="297" mass="34881" checksum="DC3C1DFCC0448723" modified="2016-04-13" version="1">MSTEFEELSAVDFLLFMDNVDSFDLIRLEYYTIEQNRKICEVFDDEPDNKGCRQLLHRFLCCMKRYPRADFINVYDAYDGQQKYICTSDPKAENYDKFWELAWCREVNTIVKISQSREEGSCQYWSSREESEIECGSFRIKTLIVIKRPRFIATLLLLSDQKNCEREIWHYHYTASPTDNNPDDPFIFLSFVCSLNDTYTISKKKQSAERKPEAVLVHCTDSSSFSAIYCILDICVTEFKYTGALSVANASRKIRQREHNCLNYNADDYSFCYQAIHMYVLGEMGLSQKYLDERGLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>S6D9I5</accession>
    <name>S6D9I5_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cc_single_5.4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">CcBV_5.4</name>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS6077</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Philos. Trans. R. Soc. Lond., B, Biol. Sci." volume="368" first="20130047" last="20130047">
            <title>Functional endogenous viral elements in the genome of the parasitoid wasp Cotesia congregata: insights into the evolutionary dynamics of bracoviruses.</title>
            <authorList>
                <person name="Bezier A."/>
                <person name="Louis F."/>
                <person name="Jancek S."/>
                <person name="Periquet G."/>
                <person name="Theze J."/>
                <person name="Gyapay G."/>
                <person name="Musset K."/>
                <person name="Lesobre J."/>
                <person name="Lenoble P."/>
                <person name="Dupuy C."/>
                <person name="Gundersen-Rindal D."/>
                <person name="Herniou E.A.Drezen.J.M."/>
            </authorList>
            <dbReference type="PubMed" id="23938757"/>
            <dbReference type="DOI" id="10.1098/rstb.2013.0047"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5092351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="HF586472">
        <property type="protein sequence ID" value="CCQ71101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S6D9I5"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5092351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCQ71101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="59" mass="6593" checksum="4A19E4F0F7696D7A" modified="2016-04-13" version="1">MMFRKAGLPTPRAPEGRSNTSNQSLVVNRQRDRYPNEAVLSFDVTFLKLGNNSLLITGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2E0A3</accession>
    <name>A0A8J2E0A3_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DDE Tnp4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HICCMSTLAB_LOCUS79</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030000544">
        <property type="protein sequence ID" value="CAG5071645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2E0A3"/>
    <dbReference type="OrthoDB" id="2668416at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027806">
        <property type="entry name" value="HARBI1_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13359">
        <property type="entry name" value="DDE_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE Tnp4" evidence="3">
        <location>
            <begin position="4"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG5071645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="77" mass="8826" checksum="253DA6DA1B3C78A1" modified="2022-05-25" version="1" fragment="single">MTNVLTPFKDNGHLTPQQVRYNVRHASLRSSIERAFGILKAKFRRLNYLDVQSLQTANLIVAAACTLHNFTLAREER</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2E270</accession>
    <name>A0A8J2E270_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Proteasome subunit alpha type-2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HICCMSTLAB_LOCUS1213</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="1">The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the peptidase T1A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001116">
        <property type="protein sequence ID" value="CAG5075015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2E270"/>
    <dbReference type="OrthoDB" id="431557at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019773">
        <property type="term" value="C:proteasome core complex, alpha-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03750">
        <property type="entry name" value="proteasome_alpha_type_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000012">
        <property type="entry name" value="Proteasome subunit alpha type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050115">
        <property type="entry name" value="Proteasome_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023332">
        <property type="entry name" value="Proteasome_alpha-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000426">
        <property type="entry name" value="Proteasome_asu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003075">
        <property type="entry name" value="PRK03996.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11599">
        <property type="entry name" value="PROTEASOME SUBUNIT ALPHA/BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00948">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51475">
        <property type="entry name" value="PROTEASOME_ALPHA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6 8 10" id="KW-0647">Proteasome</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proteasome alpha-type subunits" evidence="9">
        <location>
            <begin position="5"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAG5075015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="231" mass="25665" checksum="2D20D6C89793AF6A" modified="2022-05-25" version="1" fragment="single">NKEINKLIFFSPSGKLVQIEYALAAVAAGAPSVGIKACNGIVLATENKHKSILYDEHSLSKVEMITKHIGMVYSGMGPDYRLLVKQARKMAQQYFLVYREPIPTAQLVQRVAMLMQEYTQSGGVRPFGVSLLICGWDNGKPYLFQCDPSGAYFAWRATAMGKNFINGKTFLEKRYSEDLELDDAVHTAILTLKEGFEGQMTADNIEVGICDASGFRRLDPSHVKDYLANIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2EAQ6</accession>
    <name>A0A8J2EAQ6_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS1483</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001116">
        <property type="protein sequence ID" value="CAG5075329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2EAQ6"/>
    <dbReference type="OrthoDB" id="7697653at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051057">
        <property type="entry name" value="PI-PLC_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13593">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13593:SF113">
        <property type="entry name" value="SI:DKEY-266F7.9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5075329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="312" mass="35972" checksum="31487B73EE40D186" modified="2022-05-25" version="1">MNFLDFSEACGHYFCKTYTYKPCIERYKFLSRLPNSQKLNTLVLIGTNSSLFYDESAKELQIQDLTIVQQLKYGVRVLDIGLRLLPNMLDTHSDSRLASGYFFDLLIATNDFLDLNPGELIIMLVRHIEIEPPKKDVTRSGCKILDFYIRHVEGGSRLVKNWRLNDTIGQHRGRILIGRLDYLFKGCVVDLSDKCKPATSTQLVDRQHDSSIDRKWNLISKIILDSFLNKHECLINDLSYYDGKNTRRAIAKDAGLYHHFSCDRPINDLVANEFLCPNEGLNIVVSDYMTQELGDKVNDCNFLNSSWRIGWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2EDZ5</accession>
    <name>A0A8J2EDZ5_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similar to CG42342: Collagen alpha chain CG42342 (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS1790</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001116">
        <property type="protein sequence ID" value="CAG5075648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2EDZ5"/>
    <dbReference type="OrthoDB" id="8964326at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005581">
        <property type="term" value="C:collagen trimer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030020">
        <property type="term" value="F:extracellular matrix structural constituent conferring tensile strength"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030198">
        <property type="term" value="P:extracellular matrix organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008160">
        <property type="entry name" value="Collagen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050149">
        <property type="entry name" value="Collagen_superfamily"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24023">
        <property type="entry name" value="COLLAGEN ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24023:SF1082">
        <property type="entry name" value="COLLAGEN TRIPLE HELIX REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01391">
        <property type="entry name" value="Collagen"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0176">Collagen</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="93"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="160"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="176"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="229"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="250"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5075648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="325" mass="31523" checksum="2575847B62EAA39F" modified="2022-05-25" version="1">MPGRNGTRGVPGRRGDKGDKGDRGLTTSLDGKQIPLGTFEGPPGPPGPPGAQGEKGDLGPIGPPGPPGEKGARGKQGKRMTGDCRCPRSLRIGLPGLPGEKGNPGNPGLPGPKGDAGVPGAAGVNGINGEAGIQGPPGLPGLAGPKGEKGEYGDIGPPGLMGPPGLPGPPGAPGIKGEKGDKGESKYKKLRRRQGDGTFEVNAGEVIMGPPGPPGPAGNPGLQGPPGIKGDRGHDGTKGEPGEKGAKGDPGPMGLPGPMGLRGEAGRPGDAGKPGTMGSPGLDGMKGAQGEPGVKGERGDSGLPLNTNSICICPQGTDGIPGAQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2EEW2</accession>
    <name>A0A8J2EEW2_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS2275</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001117">
        <property type="protein sequence ID" value="CAG5076779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2EEW2"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035259284" evidence="1">
        <location>
            <begin position="24"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5076779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="258" mass="29307" checksum="9962BBFB47F978BB" modified="2022-05-25" version="1">MKTGNFFFLLCVLFGIIFSGGFSSSNDLTQIDDNKKFTVTTKALKELMQTSRDLFTLCATFSICPDVKFLSKFKKTIIEKKETTNSLTPKETALRNCSKKEDCQHGYATCIDNVNALNVWTKNAMPRLMSFVSTHLIALVLASVCWGPEKSREFPEIYCVVHPKRCIFSHYLANDQEPKAERRYLQDNPKFTWKNSSTADLSKAVHAGDFTSILVFCQTVDQFSFVGTAMADFTYCSYEDDSGRLFLTQTFNILVHED</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2EGE7</accession>
    <name>A0A8J2EGE7_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similar to TCP11L1: T-complex protein 11-like protein 1 (Homo sapiens)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS1099</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TCP11 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001116">
        <property type="protein sequence ID" value="CAG5074873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2EGE7"/>
    <dbReference type="OrthoDB" id="276323at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008862">
        <property type="entry name" value="Tcp11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12832:SF11">
        <property type="entry name" value="LD23868P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12832">
        <property type="entry name" value="TESTIS-SPECIFIC PROTEIN PBS13 T-COMPLEX 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05794">
        <property type="entry name" value="Tcp11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5074873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="504" mass="57365" checksum="8988207CC2A78EDC" modified="2022-05-25" version="1">MEEDKNINPSASIKSDDKERQWSANFLTGASPPKFVSLDEIINAANGMTNMALAHEIAVDKNFKLDAAVLENNLDGDEEAEGEADDEVAKTKKLQKKVKEIMHYAFWSLLKQQLNEDPPDYSQALVLLREIRETLEDLVLPHHKKIRENLREILDIDLIKQQAEKGVLNFTHYSHYVLNLMSKICAPVRDDKINELLKCSDIVETFKGIMETLQLMKLDLANFTITMMRPNIVASSIEYEKKKFAQFLEIQADGLQFTRRWLLKHLDDKKVADATDDNAVKQVTHYLLAEAYLDLLNWDSSPEAETLMLDQGRLLELRDKINRLAIIGSILLICGSTVGGLMQGVEKFKKNVKGHLDVILDTVHSNEQLEKIMPNVIVQIKKDVNDILKEIHSKELDKETEAILERQILELINEDHKIRTLVNLRIRQFLEKIILTQNGVPTQVPPGLSSLQEELASVAARFFIIVAHNRSVFGEYCQDIVAKEIARRKDSLGSMNHDNAVMDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2EHQ9</accession>
    <name>A0A8J2EHQ9_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS1944</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001116">
        <property type="protein sequence ID" value="CAG5075952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2EHQ9"/>
    <dbReference type="OrthoDB" id="6066929at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5075952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="114" mass="13277" checksum="D1BF4F3EF03D1B9C" modified="2022-05-25" version="1">MELHPSGVHISKCVHYVKMQRANKERRNKVFNAWGGKRNSIPFKLDPKIRRPSRMPFNSWGGKRQVDYYQDNAEDLNKKGINVADPGVKKPFNSWGGKRSFGHYYHLYSSDKPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2EHS1</accession>
    <name>A0A8J2EHS1_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Similar to ds: Protein dachsous (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">HICCMSTLAB_LOCUS291</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Cadherins are calcium-dependent cell adhesion proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cell membrane</location>
            <topology evidence="11">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001114">
        <property type="protein sequence ID" value="CAG5073345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2EHS1"/>
    <dbReference type="OrthoDB" id="6252479at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016342">
        <property type="term" value="C:catenin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008013">
        <property type="term" value="F:beta-catenin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045296">
        <property type="term" value="F:cadherin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009887">
        <property type="term" value="P:animal organ morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060429">
        <property type="term" value="P:epithelium development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007163">
        <property type="term" value="P:establishment or maintenance of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11304">
        <property type="entry name" value="Cadherin_repeat"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000140">
        <property type="entry name" value="Dachsous cadherin-related 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000020">
        <property type="entry name" value="Dachsous cadherin-related 1b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000116">
        <property type="entry name" value="Dachsous cadherin-related 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000106">
        <property type="entry name" value="FAT atypical cadherin 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.60">
        <property type="entry name" value="Cadherins"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.900.10">
        <property type="entry name" value="TCF3-CBD (Catenin binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039808">
        <property type="entry name" value="Cadherin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002126">
        <property type="entry name" value="Cadherin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015919">
        <property type="entry name" value="Cadherin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020894">
        <property type="entry name" value="Cadherin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000233">
        <property type="entry name" value="Cadherin_Y-type_LIR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027397">
        <property type="entry name" value="Catenin-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24027:SF422">
        <property type="entry name" value="CADHERIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24027">
        <property type="entry name" value="CADHERIN-23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01049">
        <property type="entry name" value="CADH_Y-type_LIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00028">
        <property type="entry name" value="Cadherin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00205">
        <property type="entry name" value="CADHERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00112">
        <property type="entry name" value="CA"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49313">
        <property type="entry name" value="Cadherin-like"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00232">
        <property type="entry name" value="CADHERIN_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50268">
        <property type="entry name" value="CADHERIN_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 10 11" id="KW-0106">Calcium</keyword>
    <keyword evidence="6 11" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2 11 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="633"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="15">
        <location>
            <begin position="32"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="15">
        <location>
            <begin position="87"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="15">
        <location>
            <begin position="287"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="15">
        <location>
            <begin position="403"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="15">
        <location>
            <begin position="523"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="711"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="901"/>
            <end position="923"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="946"/>
            <end position="1000"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="724"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="735"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="946"/>
            <end position="969"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CAG5073345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="1000" mass="108482" checksum="ED6325D1D9012729" modified="2022-05-25" version="1">MLLDEHTRLLIKQQYSPALTYRFGNVNHPSPFSIDRYGGKVTLTEPLDAEDCDEYTVQVIASDGIHEAITDLTVRVLDVNDNHPKFQQAAYIATLSEGRGEVRELLAVNATDEDLLEANNVVHYHLLSPVKGFSINSETGVITANRTALSRPVPKEIELIVVAQDSGKPALSSTCSVIIRLSGLRNSSSNREFKISVSENATRGTSLLKLADLGLLDGSIVSQEGTDVFEISRGRLIISKNLDRETKDRYNIYLGTKTSNSSNLSTEDVVMVTIQIDDSNDNYPHFTEDLQEVTIKEDAPIGTVLTTIRASDNDLSGALSSTITYNITSGNDRHLFQIDPSTGLITVNSTLDCDLSPETHHLVILACDSDPVPLCSLARVRIHISDVNDNSPKFPVHEYLEFVGENEPVGTRVFSARASDLDRGIFGTVNYSIISAAASGFTDIDDSWKLFNVNPLTGTVTTGAIFDYEQRNRYAFTLRATDTGGRTAAVKVRVEIDSRDEFYPQFTERMYRFDLRNGLQTVPGTVVGHVTATDRDKGPDGRVVYQLTSQHPYFKLNRTTGALIVKKKLHYDSEESSRLVVSASSGRQRSLSNMTVVEVRIIDDESNSLFSTNYPSNLGANMAVATSNGLADWALGLLIALVLLIAGFGGFFLFVHLKNRKHKKPSAKPGLNGDGGATASNSYVDPTAFDTIPIRGVAAASVPNSQGACQFAPPKYDEIPPYGTSGQSIGQQATSEISGSDQSGSSGRGSAEDDGEDEEIRMINEGQAPDSASDLSVHNTQEYLARLGIVDAPSANSHSHARRPPEALPLDSIHLFEDEAVTEAEIATLIYGKIGESRRPTSELEVPGGPSMNGSLSSIVHSEEELTGSYNWDYLLDWGPQYQPLAHVFSEIARLKDDASVQSSGNRHKVQQHKAPPPPLLTSVAPRSIAAPALARAMLPRSPISHDTSTFPSAALSPSFSPSLSPLATRSPSISPLVPPTPQRAQNPRNLPVVDSELRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2EI76</accession>
    <name>A0A8J2EI76_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">type I protein arginine methyltransferase</fullName>
            <ecNumber evidence="1">2.1.1.319</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HICCMSTLAB_LOCUS2263</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>L-arginyl-[protein] + S-adenosyl-L-methionine = N(omega)-methyl-L-arginyl-[protein] + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:48100"/>
            <dbReference type="Rhea" id="RHEA-COMP:10532"/>
            <dbReference type="Rhea" id="RHEA-COMP:11990"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29965"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:65280"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="5">
            <dbReference type="Rhea" id="RHEA:48101"/>
        </physiologicalReaction>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.319" evidence="1"/>
    <dbReference type="EMBL" id="CAJNRD030001117">
        <property type="protein sequence ID" value="CAG5076735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2EI76"/>
    <dbReference type="OrthoDB" id="7848332at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042054">
        <property type="term" value="F:histone methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035242">
        <property type="term" value="F:protein-arginine omega-N asymmetric methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035241">
        <property type="term" value="F:protein-arginine omega-N monomethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000003">
        <property type="entry name" value="Blast:Protein arginine N-methyltransferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.160.11">
        <property type="entry name" value="Hnrnp arginine n-methyltransferase1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025799">
        <property type="entry name" value="Arg_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055135">
        <property type="entry name" value="PRMT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11006:SF122">
        <property type="entry name" value="ARGININE METHYLTRANSFERASE 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11006">
        <property type="entry name" value="PROTEIN ARGININE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06325">
        <property type="entry name" value="PrmA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22528">
        <property type="entry name" value="PRMT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51678">
        <property type="entry name" value="SAM_MT_PRMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein arginine N-methyltransferase" evidence="7">
        <location>
            <begin position="151"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00049303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF22528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG5076735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="346" mass="39442" checksum="C6C28BD73052744F" modified="2022-05-25" version="1">METPDEYFSSYENFEVHGLMLSDNPRMTAYKNAILDKKDLFHNKIVMDVGSGTGILSIFCAQAGAAKVYSVEASKLSELIEQVVDENNYKEVIKIIPSKLEDIKLEINEKVDIIVSEWMGFYLVHEGMLDTILTARDRFLKSDGLIFPCIAKLYAVPCQVPSLFEFWENIYGVKMTCIGKAMREQKSSKPEIILVDPKDIIAEEKILAWIDLKTATSDDLNTIGGQDLVFPSTKNGKFEGVCIWWDVEFHDDLILSTAPSEPPTHWKQTLITLPNNCQVEQGEPIAFRVTLNRNNDRRKYNLELVVLNPDETDHDLPCSCYFTKCIVAREYLKHHSQEIDTNNGFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2EIK9</accession>
    <name>A0A8J2EIK9_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS758</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001114">
        <property type="protein sequence ID" value="CAG5073986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2EIK9"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5073986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="91" mass="10674" checksum="E7495356CAB19E5B" modified="2022-05-25" version="1">MYSDGTFLKRSIYYRLDESNLDPPKRVDHLFICAEAGKLCSDKVRTSLQNLTERNYEANLDACIRQLPRGPLMKEICVFFKEIERRKDTKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2GZK2</accession>
    <name>A0A8J2GZK2_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS706</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001114">
        <property type="protein sequence ID" value="CAG5073934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2GZK2"/>
    <dbReference type="OrthoDB" id="7679028at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="329"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="550"/>
            <end position="572"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5073934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="602" mass="70230" checksum="8DFFF14564534963" modified="2022-05-25" version="1">MSLCSDGRILDKIVLQNPQPAWNKMSKLIKLCFSERTNPVVITDDLVDVIYGASRDIDQSHVNIIDHDYQARKIQIFNPAYPTYILSANSAGELKDLLLALKSSPTWSINSVFFVIGINEESCDKASKILQVLWKMNLISAFYVCYEPDDKDTMILYTYNPFTNRAPEPWVEVELTDRPDNRWSLYKQPYIDDKEACKSLTYDKTKSLDGYEVKAVSRSFLNYTHGKTYDLDSLQKHNKVQNIMYPKTLFSALNITPIVYYSQSGYWLNNTAFGYLKELMNSTYNLALDVRKLESISDIDFINLNRQYSVMILTQRISIVRTIKNYEKFLSFEIISVTILILVVSFVILVIHNGRNYGNGFLDIIRLSIGAGIDAPLDKLPVRQIFSYSTKPEQSYPENLKDLGDFKFNIYYPSYMKNFINEQTSILNLNKTYLRPFSYHPSNCHDKVLNDSSNACLAYLYYQIQAAYNYNLHLAKKKLDPFYVTYWTNKDWVLQERVNKVTSEFLEIGLFELWDKQRSKYIFEKFKAKEIVENASVEYDEIEFENLESIFLFILLCFFLGILIFVAEILIVKYKAARHRRTIIRTLEKRVKYVGGRLIPIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H233</accession>
    <name>A0A8J2H233_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Olfactory receptor 231</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HICCMSTLAB_LOCUS996</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001114">
        <property type="protein sequence ID" value="CAG5074276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H233"/>
    <dbReference type="OrthoDB" id="7548151at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005549">
        <property type="term" value="F:odorant binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004984">
        <property type="term" value="F:olfactory receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004117">
        <property type="entry name" value="7tm6_olfct_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21137">
        <property type="entry name" value="ODORANT RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21137:SF35">
        <property type="entry name" value="ODORANT RECEPTOR 19A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02949">
        <property type="entry name" value="7tm_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0552">Olfaction</keyword>
    <keyword evidence="8 11" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="9" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="83"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="246"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="281"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="348"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAG5074276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="379" mass="44113" checksum="815AC15CF0DD3070" modified="2022-05-25" version="1" fragment="single">IIATTVYDTISNFTLVILSENICYIFPMSVILTKMIFAFFNENKIRKIVEEIYKPIMILKQSSDVGVLTIIQTAMSYQFFDSAIYIFLCISISGTTFLLVDIERYELPIRGVFLINATVSPNYQVIFAIETYAIIINCWWLYSLDTVLLGLVRWITIDLKILQLNYRQCQFFYEPRGTLMVTQEGFNAVKNYSFIEKLKNEDEIYNFVPFDEKQTNVTNDSFLLRFCDCVKNHRRLIESLDNFNELFGLILFAQIASDCLLTCIGLFQFSLTIKRKRKNNIFRDMVMLGSGLIHLGYWSVYGNLLINEHERLSKTVYACGWENHNGRKIKPVVVFGLYQTLTPMVMKAGYFFVFGMETYLSVIQKAYSYFAILNTMMTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H271</accession>
    <name>A0A8J2H271_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS1117</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001116">
        <property type="protein sequence ID" value="CAG5074905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H271"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="62"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5074905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="110" mass="12353" checksum="FE9F03227AE7B748" modified="2022-05-25" version="1">MTLATDCFAPAILLAIHLSSLKYVTKLITAGADVNQVMFIGKTYELKSPRFNDMRNSRIHFVEFTPLEFAVQVDKYQIAEYLISQGANIYGRNDSKGFHSSLLSQITSKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H2A3</accession>
    <name>A0A8J2H2A3_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Similar to EDRF1: Erythroid differentiation-related factor 1 (Pongo abelii)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HICCMSTLAB_LOCUS1237</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001116">
        <property type="protein sequence ID" value="CAG5075058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H2A3"/>
    <dbReference type="OrthoDB" id="419432at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056583">
        <property type="entry name" value="EDRF1_TPR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15000">
        <property type="entry name" value="ERYTHROID DIFFERENTIATION-RELATED FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15000:SF1">
        <property type="entry name" value="ERYTHROID DIFFERENTIATION-RELATED FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23723">
        <property type="entry name" value="TPR_EDRF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EDRF1 TPR repeats region" evidence="3">
        <location>
            <begin position="227"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="37"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="531"/>
            <end position="569"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG5075058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="642" mass="75037" checksum="9D7A8E7BA65A975D" modified="2022-05-25" version="1">MEGLECLKYFPEEKEEKEEEVLKMAKSFEAIPMPYESLKEEKKKKKKERKKDKGRDEGNSKAVCKKMENLPTWQKKSDIQDWKNHLKILLYEKATLIFAVLGEYEYTNQRFGRSLRYSLAVLRCHRILEIFCGMKNDKLISYLLGRAGDCCLMIVHDWQNIEEHKRAYEEADDVEVRIVSELFDMDMNVEELLPETLTTLEATLIVSLNCYEQALALGPLEPDKNILIRRLGNIHNELGVLYMNQATSKYQQVDQEDSTPVAEVTSLLTKSCQHLEAGVKAFETSKDDVNLALLHSNSGRLMRTWAHFPDKRQSQEKYFYNKAIMSYQTALQVLGSKKINPFIWEDVTWELSSTLYAMATLTQDFNNSNHKTEEEVTREVVELLQKALKYCDTETPGPRQPIYQFRAANIQHRLGSLYHRVYRELDQEEVNKRKTSLQLSRLHYEKAAKLFMALEQPVEFLTVQMERVALQEHQASTSTFTKKLKAYQSGLDLILETTPMLEIMIEKHKDNKIKFDGNKENLEVMNGENKNKYSEEDKENQEVKLRNLKKESEEEIEENQQNEKEENLIVLMEQRLQYLLKSLAKLCIDKNVNKKEYENLSSTYKFCYGKTLRPVNKSGVDLLEHLVKVLTEITPKIRQLND</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H407</accession>
    <name>A0A8J2H407_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Similar to blp: Mitochondrial import inner membrane translocase subunit Tim16 (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HICCMSTLAB_LOCUS1934</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TIM16/PAM16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001116">
        <property type="protein sequence ID" value="CAG5075932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H407"/>
    <dbReference type="OrthoDB" id="10262892at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005744">
        <property type="term" value="C:TIM23 mitochondrial import inner membrane translocase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.110:FF:000006">
        <property type="entry name" value="Import inner membrane translocase subunit TIM16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005341">
        <property type="entry name" value="Tim16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12388">
        <property type="entry name" value="MITOCHONDRIA ASSOCIATED GRANULOCYTE MACROPHAGE CSF SIGNALING MOLECULE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12388:SF0">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03656">
        <property type="entry name" value="Pam16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0811">Translocation</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="30"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="44"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAG5075932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="128" mass="13974" checksum="006B0C24667D0B6D" modified="2022-05-25" version="1">MAKYLIQIIVLGSQVVGKAFTRAVRQEMAASQEAARRAGGGSKGAQSAAASARTGLSLEEAKEILNIKNLKDPDQLEAIESNFKRFFEANDRKNGGSFYLQSKVVRAKERLDEELANSRTSKQKPSAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H5B8</accession>
    <name>A0A8J2H5B8_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">1-acyl-sn-glycerol-3-phosphate acyltransferase</fullName>
            <ecNumber evidence="5">2.3.1.51</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HICCMSTLAB_LOCUS287</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a 1-acyl-sn-glycero-3-phosphate + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphate + CoA</text>
            <dbReference type="Rhea" id="RHEA:19709"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57970"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="ChEBI" id="CHEBI:58608"/>
            <dbReference type="EC" id="2.3.1.51"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol 3-phosphate: step 2/3.</text>
    </comment>
    <comment type="domain">
        <text evidence="5">The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.51" evidence="5"/>
    <dbReference type="EMBL" id="CAJNRD030001114">
        <property type="protein sequence ID" value="CAG5073336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H5B8"/>
    <dbReference type="OrthoDB" id="202234at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003841">
        <property type="term" value="F:1-acylglycerol-3-phosphate O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006654">
        <property type="term" value="P:phosphatidic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07989">
        <property type="entry name" value="LPLAT_AGPAT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004552">
        <property type="entry name" value="AGP_acyltrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00530">
        <property type="entry name" value="AGP_acyltrn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10434">
        <property type="entry name" value="1-ACYL-SN-GLYCEROL-3-PHOSPHATE ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10434:SF11">
        <property type="entry name" value="1-ACYL-SN-GLYCEROL-3-PHOSPHATE ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69593">
        <property type="entry name" value="Glycerol-3-phosphate (1)-acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 8" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="5" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="99"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="Phospholipid/glycerol acyltransferase" evidence="7">
        <location>
            <begin position="66"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG5073336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="241" mass="27167" checksum="35E5BB53CEB115EC" modified="2022-05-25" version="1">MKFYTKFFLYYGLLVVTNTFLIPILLLRPRDVRNCVIVARTCSYINKLLGVTWEIRNKENLRKKACIIVVNHQSALDVLGLHQIWPLIGKGTVVSKKELFYLTGPIGIVFWLCGIICIDRRNADKARSNLNAVACKLKEEDTKLVIFPEGTRRNNGKVNPFRKGAFHMAVSAQLDIVPVVFSSQYFLETKKRFDSGKVIITALPAISTDGASVDEVMEKTYKVMDEAFQASSAEVKNSIKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H6G2</accession>
    <name>A0A8J2H6G2_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Endonuclease/exonuclease/phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS2832</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001117">
        <property type="protein sequence ID" value="CAG5078766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H6G2"/>
    <dbReference type="OrthoDB" id="7701337at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14529">
        <property type="entry name" value="Exo_endo_phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="1">
        <location>
            <begin position="2"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5078766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="271" mass="30772" checksum="155EE812D17475DC" modified="2022-05-25" version="1">MIISVYNNVGIKKIESELKGVVEENARTAEKIIIVGDLNARVGERNTEGVKEEGRLKRKSKDKVFNSEGKKLLKVCKELGLRIMNGGTEGDRKGEITFIGGKSENCGSVLDLVLTLDRGGDSGISYLKILKSIDSDHLPLILNLNEKDKAKAGAKRQGSESDHIAQEEGAIKIEEDILGWKKDKIAEYQEVIWEKWNEKITERETELEWNDMKEIIYNGAKETGMSKKRKECDKADKTKKEWFNNECKLKREEVWKALKKLTNEKDSNNKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H7U7</accession>
    <name>A0A8J2H7U7_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="18">Similar to Nucb2: Nucleobindin-2 (Rattus norvegicus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">HICCMSTLAB_LOCUS3628</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Golgi apparatus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the nucleobindin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5082691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H7U7"/>
    <dbReference type="OrthoDB" id="5982823at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005793">
        <property type="term" value="C:endoplasmic reticulum-Golgi intermediate compartment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070062">
        <property type="term" value="C:extracellular exosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057576">
        <property type="entry name" value="NUCB1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040250">
        <property type="entry name" value="Nucleobindin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19237">
        <property type="entry name" value="NUCLEOBINDIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19237:SF20">
        <property type="entry name" value="NUCLEOBINDIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25434">
        <property type="entry name" value="NUCB1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0106">Calcium</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="14" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="13" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0964">Secreted</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <feature type="domain" description="EF-hand" evidence="17">
        <location>
            <begin position="257"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="169"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="327"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="169"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="352"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="16">
        <location>
            <begin position="370"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="385"/>
            <end position="486"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00008063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="CAG5082691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="486" mass="58629" checksum="CAEC2E9C51659F55" modified="2022-05-25" version="1">MWQNYMLIQKSINVAGDIVVPDLFYQHYLEQVVEVLESDPEFRKKMRNVTQEELQTAEIAKELRFLDHNIRDKLHEIKRVEVERLRHLATKEYELTNNITIDTGHLDEYNLNTFEIEDLRKLILKTTEDITKQDKERRERFKEYEMNKKLEEEHKLKELPEEERKKYAEELEKQKEKHKQHEPLNHPGSKKQLEEVWEKEDHMERQDFDPKTFFFMHDLDGNGVWDEDEVKALFRKELDKMYEQGAAEDDLMERAEEMERMREHIFNEADQDKNGLIDYQEFLIQTKRNEYENDPGWKPIDEQEIYTPEEYEAYKKEHDIKEQVVEGLSPPQPGAAHNDQFPAQPVQLDHNQVPQQQYQQPPQQQQQYQQPPPQQQQYQPPPPQHQQQYQQPPQQQYQQQPPQQQYQQQYQQQYQQPPSQQQPQYVQNNQIPVQQQQQQHQGQVPQQQQYAQPNVQTNVNQQPNVQTNQNTVNQPQQNAVPQLNQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H833</accession>
    <name>A0A8J2H833_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Similar to Ell: RNA polymerase II elongation factor Ell (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HICCMSTLAB_LOCUS3910</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the ELL/occludin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5083715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H833"/>
    <dbReference type="OrthoDB" id="6284217at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008023">
        <property type="term" value="C:transcription elongation factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000987">
        <property type="term" value="F:cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032968">
        <property type="term" value="P:positive regulation of transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042795">
        <property type="term" value="P:snRNA transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2670">
        <property type="entry name" value="E3 ubiquitin-protein ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042065">
        <property type="entry name" value="E3_ELL-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031176">
        <property type="entry name" value="ELL/occludin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019464">
        <property type="entry name" value="ELL_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010844">
        <property type="entry name" value="Occludin_ELL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23288">
        <property type="entry name" value="OCCLUDIN AND RNA POLYMERASE II ELONGATION FACTOR ELL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23288:SF17">
        <property type="entry name" value="RNA POLYMERASE II ELONGATION FACTOR ELL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10390">
        <property type="entry name" value="ELL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07303">
        <property type="entry name" value="Occludin_ELL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144292">
        <property type="entry name" value="occludin/ELL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51980">
        <property type="entry name" value="OCEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="OCEL" evidence="8">
        <location>
            <begin position="465"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="120"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="353"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="581"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="149"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="197"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="263"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="285"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="316"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="357"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="374"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="426"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="585"/>
            <end position="604"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAG5083715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="604" mass="68934" checksum="E298AC99F0C54587" modified="2022-05-25" version="1">MPSLSSSSATAAALTARFLKSTSTPSARSQPDKKVSDLLKRPLRERLIHILALRPYKKPELYERLNKEGLKDREKKEMVNLLRILSTVRNNSYHLHRHVWNDVQEDWPFYSEQDRAMLKRRKPQNLTPPGSSDGGSSGSGQSPNSTHPGSPPAITAPPPNFMNCKRPGYYQGSDGIQTKKPRISHYRKPEPPIRTPSSANSNSSSGNIVNNNTSVSVHSGNNLSSSHNSNINNNNNNNNNNNNNNHNNNNNDVNNWNEQRQQSSDRDINYHRSERTSNSDVLRGNNNNNSYQLNVNNNNNSKSSFTPNRDRDELISNSNSNRTASSSAAASSLSSSSAMMLSSASTFNAAKYDSRGHCNSSPSAGVNNGSNEFSARERERERERERERRERDREEVRREREREREKLERLERVERQERERTREINSDNNWNGNASRNLGGTVPEYRTAGTGAVGYETNGNNNDIPDYLMQYKPVTNVEQRRKYKDDYSRDQPEYTELCAHKLNIKKHFEKLKELRAIESARGNREKEEEINSQIIADYDKIKHDRVEIEKDRRYNYLLGKLKYIRGLISDFDLGYSKEERENSDAIGSNNNSSKTGVSTTDLRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H883</accession>
    <name>A0A8J2H883_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">BOS complex subunit NCLN</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HICCMSTLAB_LOCUS3946</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nicastrin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5083844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H883"/>
    <dbReference type="OrthoDB" id="5913609at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009966">
        <property type="term" value="P:regulation of signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03882">
        <property type="entry name" value="M28_nicalin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016574">
        <property type="entry name" value="Nicalin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007484">
        <property type="entry name" value="Peptidase_M28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31826">
        <property type="entry name" value="NICALIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04389">
        <property type="entry name" value="Peptidase_M28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="17"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="489"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M28" evidence="11">
        <location>
            <begin position="171"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00034873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF04389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAG5083844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="531" mass="59696" checksum="38031D630038704F" modified="2022-05-25" version="1">MWLEQCDSFAELCRSYLPYYLLIVLPIFIVVSPVNPVAASHELPVYRMHQYDLHGIPHGCRSASVLLEARGLSNWRTSRHCVIARLNDLTPDLFYTIKNKAGALVIMLPKDMTNLTIDQQQVGFSTNNNGVKTSSEIQSLIDIVSASGYQVIVSAGQPIPRNDVKIATIHGRLSGTGAEDKLPTIALVAYYDSSSVVTELSTGAESNASGVSMLLELARIFSALYSIGKSRPKFNVVFVLSGGGKLNYYGSKKWLEDQFDGLEGSVIQDASYVLCLDALSLTDNLYLHVSKPPKENSFGYLFYNELKTVIESYNSKTEDNVSLEGIHKKINLADESLAWEHERYSIRRLPAVTISSLRSHDNPLRASILDINDNKKLDRLHRNTKLVGEALARRIYNLNSTEILSTPVAVSKTSLNVWFNYLTSQSRSVPILSDSKNSNNPLVNSLHEYMQRYLSDVKINYYSADKRDPEFVFYDNTKTIMNVYSVKPAIFDLFLTIAIAVYLAIIYLAVYKFSNFYSFVERFASYKNKVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H8V0</accession>
    <name>A0A8J2H8V0_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Similar to Carmil1: F-actin-uncapping protein LRRC16A (Mus musculus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HICCMSTLAB_LOCUS4500</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CARMIL family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5087386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="18598at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030027">
        <property type="term" value="C:lamellipodium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034315">
        <property type="term" value="P:regulation of Arp2/3 complex-mediated actin nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031943">
        <property type="entry name" value="CARMIL_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041245">
        <property type="entry name" value="CARMIL_PH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051279">
        <property type="entry name" value="PP1-Reg/Actin-Interact_Protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24112:SF66">
        <property type="entry name" value="LEUCINE-RICH REPEAT, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24112">
        <property type="entry name" value="LEUCINE-RICH REPEAT, ISOFORM F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17888">
        <property type="entry name" value="Carm_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16000">
        <property type="entry name" value="CARMIL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00368">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="CARMIL pleckstrin homology" evidence="11">
        <location>
            <begin position="25"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="CARMIL C-terminal" evidence="10">
        <location>
            <begin position="800"/>
            <end position="1124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="975"/>
            <end position="1089"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1104"/>
            <end position="1279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1292"/>
            <end position="1428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="975"/>
            <end position="987"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="993"/>
            <end position="1006"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1044"/>
            <end position="1062"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="1065"/>
            <end position="1076"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1104"/>
            <end position="1117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1129"/>
            <end position="1138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1215"/>
            <end position="1247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1256"/>
            <end position="1279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1292"/>
            <end position="1314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1331"/>
            <end position="1344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="1345"/>
            <end position="1355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1367"/>
            <end position="1387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1403"/>
            <end position="1423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF16000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF17888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAG5087386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="1504" mass="164675" checksum="DFF66FF6D37DFCFE" modified="2022-05-25" version="1">MSTRSQLTKDLNESVKALLGKHVKILLKNVVKLETKPDKQENRVLVFSPCRLFLLTAKVPTRIDCHFHYLEITSVESRRSNQLCLTAGERTYNFTTTGVGGTDTTEVDAMIEALHTAIRNIFPTVPLNYVIRKIDVIPASRLHSIRGSELARSTEATRTTGPCGGFSTQYACMCDLHCVQYREEVTWDVDTIYLSHDTRELNLRDFDHLEQKDLVPIISALEYNTWFTKLRVSHLKLSHECLERLLHVVRRSLSLQEIYLDNLGLKWDFAHKLSLALIANSNTVLHTIDLSNNMIEDKGAASLCAIVAKLTQGSSHLGSPGIGKLPKGMQKLNLSHCGLTGKGIAQIAHALSLNRSMPTSLRYLNLSENTLKDDINNLCNFLAQPNSLTHLDLAGTDTTLESLFGALLRGCATNLVHLNVSRNSFTSKKTKEIPPSFKQFFTATLSLKYLNISYCKLPLEALKHLLLGLACNESTVGLELDMSGNNLGSLGAHVLESCIHGVRCIASLDISDSNMDVDMAQVITAIGKNKSIKHLYMGRNTTGMKTKHISVVMDALVQMIQEDDCVLQSLYIPDSRLKSDLYSLINALGSNTCLHTLDMSGNQIGDPGARLLAKALQINNHLKTIIYDKNNITLQGYSDIVHALEKNYSVRHMPFPIYDLQPCMKISAEKAEQLAKKIQDMLQRNVTPCKYSPGQAFRLQQGFLLSSTQQVVDRLVVQTQDTIKTLAAESCDANNDINHATGLIQDADNSKQLLPRLHEVLQRRDENNPVEAKLKEIADNLYKNVTDYLEDSLEAILKCANDHCPTVMSQTVIRGDESEPISVEDDLRNVCKGKNQISGEFITSAIVEQAGTDIVNRINELNLSVAAHISDRITDEVIESLSRSYKTLIGDSHDRTRCSTPDVLRPSVSSTSSGSVIGIGGTMSIGISSDNSGYGLSNKISSAVEHAAKMTRDSLKDSMVHEYACPSDLFIGSSINSQHTTDDQSPMATPHLSNKRKNLHGRKLRPKSVVDSVEGLSADDIPDLLPSLPKDNTETISENEHSLTESLDSISELPNNTGQQLQHLVKSRPRRTKTRAPSRPMLRTDIPKGSLGLGEGLDVFFRPTTPTTPLISPTSDDSSLHTFPIDGSPNLSITSQRSIPPETDKKPHGCNSPILKTLLEPTPRSRSSDNFEKFSPLAGRRSQGDTPLTASPLARRSAAENSQSQEPEARKARGIQSTSTAGSPLSTPTTRLSRDLSGNETSESSPDGDNHKTSVRSHGSILSSSADNEKSVSGQATNKFRSISSIQESRGAFNSLQSEVCPSNDSNKQLSNAGSFKAPSKVSYNISGEQSRSSSSINSSRNSKPLPPATAPKPRPWSMTGDRKSGEFNNLLSDGSSPNTSAGNTPDSGDALDESTDSGVSGPASLPPTLSASSTASSLSSSTVEKRSVRELAASLNKGKTDRKENEESVPIAWRSVLHRSVDRTVNKEQVPKKDEDNRINFKLRRTSFLRDSNFNYDNDVVDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H955</accession>
    <name>A0A8J2H955_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Sulfhydryl oxidase</fullName>
            <ecNumber evidence="6">1.8.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HICCMSTLAB_LOCUS3796</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>2 R'C(R)SH + O2 = R'C(R)S-S(R)CR' + H2O2</text>
            <dbReference type="Rhea" id="RHEA:17357"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:16520"/>
            <dbReference type="ChEBI" id="CHEBI:17412"/>
            <dbReference type="EC" id="1.8.3.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.8.3.2" evidence="6"/>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5083297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H955"/>
    <dbReference type="OrthoDB" id="7658313at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016972">
        <property type="term" value="F:thiol oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.310">
        <property type="entry name" value="ERV/ALR sulfhydryl oxidase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036774">
        <property type="entry name" value="ERV/ALR_sulphydryl_oxid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017905">
        <property type="entry name" value="ERV/ALR_sulphydryl_oxidase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69000">
        <property type="entry name" value="FAD-dependent thiol oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51324">
        <property type="entry name" value="ERV_ALR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 6" id="KW-0274">FAD</keyword>
    <keyword evidence="2 6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ERV/ALR sulfhydryl oxidase" evidence="7">
        <location>
            <begin position="151"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU371123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG5083297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="276" mass="32981" checksum="845B54454316A8C2" modified="2022-05-25" version="1">MDSTSKEEKNELHPKQMLEDNYKNIKNNSEEDNHHEFHYKATLLRHTYNLNPERINEVQENFKKYLNIFLAYIRTDKPESADFFQRVTLGRFFKKLFMLITFVIHPINCDESLKQLNNMNDVTLCNTMLYEECREFFGLKSILEPKKLDQEEWSLDEWGKNYWNFLHALSILVQYEYQKDSNHPAMDYLALIMVNFHIILPCSVCSVHYKERNPLVNITLPILHGKDAIYVIYELHNIVRLRNGLVWFPIESFVKNWNLEILKSENVDIDITEPLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H9K7</accession>
    <name>A0A8J2H9K7_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Similar to CD63: CD63 antigen (Oryctolagus cuniculus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HICCMSTLAB_LOCUS5043</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the tetraspanin (TM4SF) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5088965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H9K7"/>
    <dbReference type="OrthoDB" id="10051815at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03127">
        <property type="entry name" value="tetraspanin_LEL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1450.10">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018499">
        <property type="entry name" value="Tetraspanin/Peripherin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018503">
        <property type="entry name" value="Tetraspanin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008952">
        <property type="entry name" value="Tetraspanin_EC2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19282:SF456">
        <property type="entry name" value="CD63 MOLECULE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19282">
        <property type="entry name" value="TETRASPANIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00335">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00259">
        <property type="entry name" value="TMFOUR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48652">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00421">
        <property type="entry name" value="TM4_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="16"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="60"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="87"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="213"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="255"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="377"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAG5088965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="406" mass="45069" checksum="9D4F7D92BE968A9B" modified="2022-05-25" version="1">MVTDLKLPLGSRCIKYLLFIFNFLFVISGIILLSVGATIRTVYSNYNHFLDDKFFSVPSLLIVIGSIIFFIAFFGCCGAVRENYCMIVTFCALMVLVFILELSGGISGYVLRNNAAQMIEAKMKDNMEKYKNNETEIKMIWDDMQTNFECCGAKGPDDWLEHNGSLPISCCPIPPGQMAQFNCNNQTKDVYRTGCVNKFGSYVKDHAIQLGGAGLGIAFVQLTGVMIISVGMTIYTVYDDFRNFLDPRYSSPAMILIFVGVSLSVVLVLEISAAIAAYALRGSIKSLLAENINLQMQLYKTSDEAAAAIDFLQSRLQCCGNYDKSDWEEINLMDSRASVYPDSCFSWISSIYNPRFNNVLYEDGCIQRLSMIINQSAISLGTGAFAIVLIQVIYGSDVCLHSGTRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H9U4</accession>
    <name>A0A8J2H9U4_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS5083</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5089046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H9U4"/>
    <dbReference type="OrthoDB" id="7474542at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017956">
        <property type="entry name" value="AT_hook_DNA-bd_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02178">
        <property type="entry name" value="AT_hook"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00929">
        <property type="entry name" value="ATHOOK"/>
    </dbReference>
    <dbReference type="SMART" id="SM00384">
        <property type="entry name" value="AT_hook"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5089046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="119" mass="13121" checksum="2BE22320435B93CF" modified="2022-05-25" version="1">MSDDNSPVVEEQKKKRGRPPKNADSKNAVKEPKKRGRSAATEKINASRPPKSDNEDDAPPGPVKRGRGRPKGSHKKKNPAKTTAPSPGRGRGKPKKIEEKPESTGEEEEMEEEDDEEEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H9V6</accession>
    <name>A0A8J2H9V6_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Isoallergen Bla g 6.0101 (Blattella germanica)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HICCMSTLAB_LOCUS5272</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the troponin C family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5089528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H9V6"/>
    <dbReference type="OrthoDB" id="26525at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016460">
        <property type="term" value="C:myosin II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000001">
        <property type="entry name" value="Calmodulin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000103">
        <property type="entry name" value="Troponin C Ib"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050230">
        <property type="entry name" value="CALM/Myosin/TropC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048:SF0">
        <property type="entry name" value="CALMODULIN LIKE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048">
        <property type="entry name" value="MYOSIN LIGHT CHAIN 1, 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0514">Muscle protein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="6">
        <location>
            <begin position="105"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="6">
        <location>
            <begin position="175"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="6">
        <location>
            <begin position="211"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="6">
        <location>
            <begin position="251"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="6">
        <location>
            <begin position="287"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAG5089528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="321" mass="36638" checksum="E8D1F722B0F1C611" modified="2022-05-25" version="1">MKKERDALQDFQVQLIHSDGLIGQLYFFSLELKTAFDAFDHQKNNTIQTSDIATIVNMMGIELENPADLDNAIMEVDTFGSGEAKFDDFCAIVARFMEEDVDVETLKTELKEAFRLYDREGNGYITTECFREILSEIDENLNDDELDMMIEEIDADVKGVYVNYLFFPQEDLTKDQIVLLKKAFDAFDHEKKGCIGTDMVGTILTMLGHELSENTLAEIIAEVDEDGSGELEFEEFCTLAARFLVEEDTEAMQQELREAFRLYDKEGNGYITTEVFRDILHELDDKLTNEELDLMIEEIDADGSGTLDFDEFMEVMTGGDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HA65</accession>
    <name>A0A8J2HA65_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Similar to RF_0381: Putative ankyrin repeat protein RF_0381 (Rickettsia felis (Strain ATCC VR-1525 / URRWXCal2))</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HICCMSTLAB_LOCUS4908</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5088604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HA65"/>
    <dbReference type="OrthoDB" id="539213at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050663">
        <property type="entry name" value="Ankyrin-SOCS_Box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24193:SF121">
        <property type="entry name" value="ADA2A-CONTAINING COMPLEX COMPONENT 3, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24193">
        <property type="entry name" value="ANKYRIN REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="48"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="141"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="183"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="217"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="250"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="515"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAG5088604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="515" mass="58591" checksum="2ABA61D0C82E32AA" modified="2022-05-25" version="1" fragment="single">MANLSNMLASMKIPNICSLEINVTAVEELLNQPNTNFNMIVFDKSQALRYYTILLYMTVIYCTMRLIVYLRDREEINVTVVEEFLNKPDNNVNSIVYSEDRAFSCFSYTTLLGLAVEKSDEELIAYLIDRKANLEGSSFHGKENPLYIAAVNGDTKVFKKLYHLGANIHLKSDINWLPINSILRLSPLIIAARCGHLEIIKFLIEQGLDVNFTESECGSSLLHHAAASSNCKLVKFLLDNNAKINAKNHNGETPLLCAISSEKINIVKLLIARGADINNGQGSIERSTEIHSVYNKKSIREYLTSSGKWMTNKDFILNKTGQPILHYKLSSFDTCAKSCSIILDAGVDVNVQDSRGQFDCGCHMSYHDTLRAIIVQLILTLTLAGLTVCKENQQAVENGYENLRKTCLEEIQKMKINKVGVSNITFFDVLHMSFHYLAIRLKFAGLDQVIKEKLIAYPLYKGMLYYKLSEVRRRIKYLEEVEKLFEGMLWDLGLPATFIRELWSYFTNIDYTRQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HAF6</accession>
    <name>A0A8J2HAF6_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HICCMSTLAB_LOCUS5090</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5089067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HAF6"/>
    <dbReference type="OrthoDB" id="1405595at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="11"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="33"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="36"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG5089067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="91" mass="10822" checksum="7B44CCBEA062656F" modified="2022-05-25" version="1">MMQQGQSQEILSCDVCGITYKFMSSLTRHMVTSHMNPEKLRQQAEEQRRKRENNYKRYLENRKMYETQHGTGYGKRSYRSAMSSDPDDDFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HAH0</accession>
    <name>A0A8J2HAH0_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 13">Protein-tyrosine sulfotransferase</fullName>
            <ecNumber evidence="3 13">2.8.2.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">HICCMSTLAB_LOCUS5460</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Catalyzes the O-sulfation of tyrosine residues within acidic motifs of polypeptides, using 3'-phosphoadenylyl sulfate (PAPS) as cosubstrate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 13">
            <text>L-tyrosyl-[protein] + 3'-phosphoadenylyl sulfate = O-sulfo-L-tyrosine-[protein] + adenosine 3',5'-bisphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16801"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:11688"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:58339"/>
            <dbReference type="ChEBI" id="CHEBI:58343"/>
            <dbReference type="ChEBI" id="CHEBI:65286"/>
            <dbReference type="EC" id="2.8.2.20"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the protein sulfotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.8.2.20" evidence="3 13"/>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5090017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HAH0"/>
    <dbReference type="OrthoDB" id="545675at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008476">
        <property type="term" value="F:protein-tyrosine sulfotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000290">
        <property type="entry name" value="Protein-tyrosine sulfotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026634">
        <property type="entry name" value="TPST-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12788:SF10">
        <property type="entry name" value="PROTEIN-TYROSINE SULFOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12788">
        <property type="entry name" value="PROTEIN-TYROSINE SULFOTRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13469">
        <property type="entry name" value="Sulfotransfer_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU365018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CAG5090017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="301" mass="34717" checksum="C94222E03E7332B2" modified="2022-05-25" version="1">MPLIFIGGVPRSGTTLMRAMLDAHPDVRCGQETRVIPRILQMRSHWLRSERENVRLSEAGISKEVLDSAIAAFSLEVIARHGEPAPRLCNKDPLTLKMGSYILELFPNAKFLFMVRDGRATVHSIISRKVTITGFDLSSYRQCLTRWNHAISLMYDQCKEVGPSRCLMVPYEQLVLHPRDWMKKILNWLDVPWNESVLHHEEFINKPGGVPLSKVERSSDQVIKPVNLEALTKWVGQIPTDVVKDMPDIAPMLSKLGYNPYENPPVYGAPDSVVSDNTRRYFYLYYYNYYYKFFIQYKSVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HAZ3</accession>
    <name>A0A8J2HAZ3_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Ubiquitin conjugation factor E4 A</fullName>
            <ecNumber evidence="5">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">HICCMSTLAB_LOCUS5839</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Ubiquitin-protein ligase that probably functions as an E3 ligase in conjunction with specific E1 and E2 ligases. May also function as an E4 ligase mediating the assembly of polyubiquitin chains on substrates ubiquitinated by another E3 ubiquitin ligase. Mediates 'Lys-48'-linked polyubiquitination of substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the ubiquitin conjugation factor E4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="5"/>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5091008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HAZ3"/>
    <dbReference type="OrthoDB" id="20295at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000151">
        <property type="term" value="C:ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034450">
        <property type="term" value="F:ubiquitin-ubiquitin ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16657">
        <property type="entry name" value="RING-Ubox_UBE4A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000055">
        <property type="entry name" value="Ubiquitin conjugation factor e4 a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019474">
        <property type="entry name" value="Ub_conjug_fac_E4_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045132">
        <property type="entry name" value="UBE4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003613">
        <property type="entry name" value="Ubox_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13931:SF16">
        <property type="entry name" value="UBIQUITIN CONJUGATION FACTOR E4 A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13931">
        <property type="entry name" value="UBIQUITINATION FACTOR E4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04564">
        <property type="entry name" value="U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10408">
        <property type="entry name" value="Ufd2P_core"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00504">
        <property type="entry name" value="Ubox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51698">
        <property type="entry name" value="U_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0007">Acetylation</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="U-box" evidence="13">
        <location>
            <begin position="1097"/>
            <end position="1171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="479"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="741"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="34"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="481"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="495"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="758"/>
            <end position="780"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00037624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00040077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CAG5091008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="1174" mass="132973" checksum="6D27A30000ABE5F9" modified="2022-05-25" version="1">MSDDFNKNPFVGLFTTPNEAASFLSQATTIDPVTTTPSAISQPVSSVQDEDDDDSVYLNENNVETGKVNHENNDREDEIIQKVFGLLLNCKTPCRGSKQQLVSIDSDDIENGIFERLTLLDIPSKLVPEKGPATADPHFLQSEVITYLFECYCRLEQQNKADNDIVENFKRITLRSAGTALQPDIFQDQEVHSQFLRLFMDDSQSSQVEKFTQELAAIIMTDYPEDAQHIFMSSFKPILEFIHQEVTNSNLIVYRQYWFNIIHTFSNIEPLAKVLISYSTPILSSTTTTTTTTTTTTSVQGSIYGSTLLGSLLSLSCLPKTFGEPFDFFNDKPLIQPTITTTEGNIWTAMNALCESLYKVIHCLLKCSSEVRHLTLDWIGKCLQANASRGKLWNNSQTSIGGNGLSPLVVSDGFMLNLGNVLLRLCQPFCTLKKTPKIDPTYCAAAVETLTEDERRTRGIHLVGINKETCLIPSTTTITIADDDDDDDDGDGDGDNNSSSSSSSSSSSDDKSDTIAAASITFGFVTECFYLTHRALDLGYRVVLDKLMKTNQELARIQRIYNDAQASSNSEVFQVITQRMEMEMTKYLSYRASLLAPELLNLLAKFHATTAFWLMQVNINIPTNLNDNLINNKNNNNDNEKNHLMKNNLNFLDQEPKLVTFPLPETVPETLKYIPEFIVENTIGFICFLRRFNPNTFEEQGENFLNPILTEIIVLMESPKRLFNPHLRAQLAETLEALLPNTSPLSYTDDSESRLGDGNDDDDDDDDDDNDNDDDDDGDGDGVSAFIDYDDDDDYSFSQRQRQQQPHLSSLGTFNREKLFINHPHCNQIVKNLIEVFVSIEMTGQSVQFEQKFNYRRPMYTVMKYLWKIKQHRDNFKRLAKEAEDNMEAVKPPLFLRFINLLMNDAVFLLDEALSNMAQLKQMLRARENGEWDKLPAHERDQKISYLHHIGMTARFDNILGRETISTFKMLTSEIKSIFCHSTMVDRIASMLNYLLLELVGPNKKNFKVKDQKEYEFNPAKLVLNICVIYINLGSNSNFTLAVSQDGRSYRDNLFKLAESVLLRIGGISILGELNNLAVRVANAAAIKKQEEEILTDAPDEFLDPIMSTLMVDPVILPSSKISVDRQTIARHLLSDQTDPFNRSPLTMDMVKPDVDLYNRIQEWISLKKQQHTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HB00</accession>
    <name>A0A8J2HB00_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Similar to cdk9-a: Cyclin-dependent kinase 9-A (Xenopus laevis)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HICCMSTLAB_LOCUS5483</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5090086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HB00"/>
    <dbReference type="OrthoDB" id="204883at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004693">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008353">
        <property type="term" value="F:RNA polymerase II CTD heptapeptide repeat kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF233">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="17"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="127"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="133"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="149"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="46"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAG5090086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="169" mass="19435" checksum="A9AA65D947F64109" modified="2022-05-25" version="1">MKSKKLQVLKRFSYSIGVREYIIGQGTFGEVFKARDTTDAKIVAMKKIIIENQTEGFPITALREIRIFQSLKHENVDAFACDLLEKLLVLDPSKRYDADSALDHDFFYTDPLPSDLGKILTQHSQSTLESHTLSRRPARHMQHPYHPISTGTTRPTVSRTYDGYQDRIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HBS0</accession>
    <name>A0A8J2HBS0_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS4277</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5085110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HBS0"/>
    <dbReference type="OrthoDB" id="8192078at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="1">
        <location>
            <begin position="4"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="1">
        <location>
            <begin position="34"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5085110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="700" mass="80571" checksum="C25EA4AA86244268" modified="2022-05-25" version="1">MPRCSTCSLDLTSIKALITHISVNHSDELNKYDCDERGCNSRFDILNSYHKHLRVAHKFPSQPPSTNNLHHSTLTRNETILSNRIENESETGTNNISCNETCENSESCDINTVNFKCELDKAAERFVAKLYANPRLPRNIVQTIVEDTHIFIGDKFLGLLESSVDTTHSKLNCPSDNHNKIKKPVSYVIDRTFVVTKNKDGTIGKYVDISGQYIPLTLSFKTFFETNNTLDIVLNYMSSLESDTTVIENFIQGKLWAEKRSKYSYNDIVIPYFLAGDDVEVNNPLSSHSSKVMPIYASFPCLPPECRSQLTNILLVLIYDSWIRDSNKKNRTYDIYRPLIQGIKYLEKNGIEINTSTGKKKIYFVLGLIQRDKLGLHGLLGFTESFAATHYCRFCKMKKNDCKNALIIPCELKRNNVNYEQDCLANNISITGIKEKCVFNGIESFHCTKNYSVDEMHDVREGIAHDDLIAILRKLTFEKSDCYSFPLSELNDRLTMYDYGPIDCSNKPPLIREEDIKNESKLKMTASELTTFVKLFGILIKDLVDKSNPCWDLYVLLPEIFDFTLAKKVTKEQILELNLFDYCNLPNVLRDRNISVTKWVEFKNIKYTPKMLVLVRYENLMPVFAEIDAIVTVNDNVNNVYLLCNYLIVLGYHEHVVGYEVMRSNSVVWINIEDLRNIFSLFVHTSLDDELYVILNYTKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HC46</accession>
    <name>A0A8J2HC46_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similar to jockey\pol: RNA-directed DNA polymerase from mobile element jockey (Drosophila funebris)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS6764</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5093355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HC46"/>
    <dbReference type="OrthoDB" id="7697216at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47027">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47027:SF30">
        <property type="entry name" value="THAP-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14529">
        <property type="entry name" value="Exo_endo_phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="448"/>
            <end position="728"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5093355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="1053" mass="119628" checksum="71279D86C7AB435C" modified="2022-05-25" version="1">MRKLAQREHSIGRPSGGLLTAVNKKHSVLLIDASPWWILKEIKLGASTIILGSVYFRKCLDLHYLLDTLQDIIDDIRATRNFDIFIIGGDMNAKVGLLNPWPADLFTGSQLHDTFCTTDDTTCERGRMITDFMVENDFVLINGRSTSDSPAQPTYDNLGSSIIDLVWTDISSLHLIKDLEVLLEPSLSDHHPVCLSISLEAILHTEEELKTRDSGLSKIKWAESAADQYREHLSNRLTSMDAQTLSTEKFQALLHDHMFSAATSANLVVRFGSTARNWTLRNPWFDASCKVARSELRKAMKNLKKDRSNAGLRNEVTLNKKKYREVCNAKKKDHVDSIKTAFDNVKAPSEFWAAVRKFSFKHGSNSEISITSWNNFYSAISKPRSISAFVPHNCTNETLDAEISIGELNRTLNSLKAGKAAGPDLLTNELFKNLPMQHKELLRDLFNRVLIEERVPKSWAKIWLTMLHKKGAKNDPNNYRGIALINIVTKIFTNTLKKRLDLWMDKENALPDSQMGFRKGRSCTDAIFTLRSAIQIQFRHNDGREIYGIFVDFQRAFDSVPHARLWQKLQALGVSSKFIMTIKSLYDQASMQVRSKEGLSDEFEVSEGVLQGESLSPDLFLLYLHDMEDFFRSKGLYGLDINGVVDILLLLYADDTVIFAHSQIDLLRKLRALEEYCDLNQLTVNKAKTKILVFKAAGRIRDCPCRYRTYKQSCLELVKSYTYLGVEISTSTRGLTALNSANNKAKCAAGAAMSLLAKAKCDSWSAHMKIYNCMVSSVFLYAIPAWGLWYRNSLEPAQTFFFKKLFKLPRNTPDWAVRLEFRLDPVALKAMGFILSWVIKTLKAKDNCLHKVCLLRLINLAKNTTASSPYNWATQLRDFLMECDALDLFDSLDHQLWEARRENILKKYQTILHSADITAARNSSSLEFPLQLPDSFSPTGYLALKLPLNCKRLIAQLRLSNKYNCFLIVNNFRSSFNRNSPCQLCNLKAPDIVEHLLVRCPCFSSFRHHFLQNLLRNGESASHLLSVPDAKTLFAIVNFITKALQLRAWALSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HCC5</accession>
    <name>A0A8J2HCC5_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Similar to MRJP1: Major royal jelly protein 1 (Apis mellifera)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HICCMSTLAB_LOCUS4830</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major royal jelly protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5088411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HCC5"/>
    <dbReference type="OrthoDB" id="6583604at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017996">
        <property type="entry name" value="MRJP/yellow-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10009:SF6">
        <property type="entry name" value="FI16876P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10009">
        <property type="entry name" value="PROTEIN YELLOW-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03022">
        <property type="entry name" value="MRJP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101898">
        <property type="entry name" value="NHL repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035144249" evidence="5">
        <location>
            <begin position="21"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAG5088411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="375" mass="41887" checksum="8B2033390466D112" modified="2022-05-25" version="1">MARVLIISLLVVTTASVVFGRARQVQQPAPDFSDLKFFVKGRNLVWPSRDTEQTFSKNGRYDRRSIIGTRIQLFEDQVFIAFPRLKPGVPITLGVVKHGNKNIYEAFPCWAMQEEGNCDSLQSIVDISVDDNGILWALDTGTVNTLTQPVFRCKPKVFAFDIRNKQLIKVIDLNQLIVENSRLQDLIVDYGEDGKVYLYISDASGRGIIVYDVVGNSGFRMSLPQAVNLANSKKDVLQMLLVRKATGPELYFTYLGSSRVFSIRLDHLRRGAGADIIDVGSKLNSMIFLGTNGGNVIFFRYKGQPDVYLWDTNTAFGQENFVIVQKGDDCHLPTDIAVGPQDTLWTIGSNLQDYIHDTIPSNGASMIIHPLVKNC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HCM9</accession>
    <name>A0A8J2HCM9_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Similar to arx: Gametocyte-specific factor 1 homolog (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HICCMSTLAB_LOCUS6908</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5093551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HCM9"/>
    <dbReference type="OrthoDB" id="5839404at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022776">
        <property type="entry name" value="TRM13/UPF0224_CHHC_Znf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05253">
        <property type="entry name" value="zf-U11-48K"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51800">
        <property type="entry name" value="ZF_CHHC_U11_48K"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CHHC U11-48K-type" evidence="5">
        <location>
            <begin position="9"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="domain" description="CHHC U11-48K-type" evidence="5">
        <location>
            <begin position="41"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="141"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="147"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="160"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="171"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="185"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAG5093551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="291" mass="32818" checksum="741A50B7BC73569F" modified="2022-05-25" version="1">MAAAYEDPKVTCPIDKSHEIFRSRLPQHLIKCLKANKLVNKMICPYNTTHLININEKEKHLMECESYAKIFIESAEMAEKPNYSGVVHFDDAVDQVTRALEASGIDGQEEKVCFIDGPAYNPEEAKINEQLYRQLNGEAKSARKNFRREEVKRHAELEAKQSTVMQNGGHRSNKAKLKKTHRPTALKDKGKKDDTSEDGSIYQGLPLNKPTEHKISEDLGEGSNVSRAEDDNSGAIASPVRSNKSADLDTSIKSKEELIEDTKTETDNFLEESDYDNATSELYKKYNVHNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HCQ7</accession>
    <name>A0A8J2HCQ7_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Neurotransmitter-gated ion-channel transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS7139</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5093813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HCQ7"/>
    <dbReference type="OrthoDB" id="8197206at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006811">
        <property type="term" value="P:monoatomic ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.390">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036719">
        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038050">
        <property type="entry name" value="Neuro_actylchol_rec"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006029">
        <property type="entry name" value="Neurotrans-gated_channel_TM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02932">
        <property type="entry name" value="Neur_chan_memb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90112">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane pore"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel transmembrane" evidence="2">
        <location>
            <begin position="30"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5093813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="113" mass="12699" checksum="E7C094B31CAD690B" modified="2022-05-25" version="1">MRVRETEKNETKESSLMLMVIQHFTSLFWISTGVTILLSLTVFLNLVAESMPTTSDAVPLIGIHPFLFSPAPCYHIMTTTSCPKEHSLFNTLFAITVSSRVLCVYVCTYECLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HD06</accession>
    <name>A0A8J2HD06_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Similar to Mtf2: Metal-response element-binding transcription factor 2 (Mus musculus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HICCMSTLAB_LOCUS7601</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Polycomblike family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5095221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HD06"/>
    <dbReference type="OrthoDB" id="10033786at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045814">
        <property type="term" value="P:negative regulation of gene expression, epigenetic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.980.20:FF:000001">
        <property type="entry name" value="metal-response element-binding transcription factor 2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.980.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025894">
        <property type="entry name" value="Mtf2_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002999">
        <property type="entry name" value="Tudor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12628:SF21">
        <property type="entry name" value="PHD-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12628">
        <property type="entry name" value="POLYCOMB-LIKE TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14061">
        <property type="entry name" value="Mtf2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00333">
        <property type="entry name" value="TUDOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="11">
        <location>
            <begin position="78"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="422"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="476"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="511"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="564"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="677"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="757"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="427"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="487"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="526"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="565"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="680"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="779"/>
            <end position="792"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAG5095221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="853" mass="95706" checksum="3727D5C942597BD2" modified="2022-05-25" version="1">MSVPEDNLAMPDSTTREQRLGFSHGEDVLLQLKDGKFYLGTIVEVDLAQERCLVKFLDNTSSWSSVKELTKLGTPDSNVMCVLCKKFKPKPDNDIIVCDKCGRGYHQHCHKPQVTTEEANVDSHWKCKRCQENILKTTRDGPDPKNSMIKANIRKVCSGRDQPQPPPEDMTKLPYDPEMLSWDSHHRVNAEQIYCYCGLNGEWYTQMLQCARCKQWFHEKCVSCLTFPLYSGDRFYVFVCSTCNYGKEFVRRLELKWVDLVHLMLYNLTVYNAKKYYDLDSVIIPYAAENWNLLQLPPRIRDISAHMRREAILSILANNRTRFKCGREIKKRTTIWGLRVRLPPPCPVVNLPVTGIIDDSVLRRCWGANRRLQYLPPPGPVIFADSPSAINTTNQEATALVTEAVSPSDIVTMGTVLSKATDVDQDTCPTPSTQDQSTESLRERYSGGGFVKKSFPFPKLNLQRRKRLMALNSTHERMLRKHKKRDKGCEDTKNQIVREARYKKARKLLKNAITKRKPLQRTPEVPDLPPTPPTSVSGPPTPPATTSAISELSVPSSVDLILNLPQPSVTPADTSGDETSSRGTLDSFIPPPKDFEGKNNPFRNLSELLSTPNISSASNLVPGTSSTPLPFHHHHHNYHNYQPPITLPLPLTPVIPHPPLIRPAKRQLSEKDIIIDRNGQVKRRRQHRRGRPPSQPQQFQATATASKTAAILPARNSEVKNDYVRNLRSSFNSSSSSSTSQIGSCVDYALNGRRLRQRGADKSAASPANAEAQKRSNLTMSMPSTSAASSSPKVSPIKQSTPDISMDDLKSSVNMYFGAANRIASGEKFGVKAKRLSKSGQLQYLIEWEGPNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HD69</accession>
    <name>A0A8J2HD69_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Similar to lz: Protein lozenge (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HICCMSTLAB_LOCUS5948</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5092148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HD69"/>
    <dbReference type="OrthoDB" id="10029800at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001709">
        <property type="term" value="P:cell fate determination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.720:FF:000001">
        <property type="entry name" value="Runt-related transcription factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.720">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000040">
        <property type="entry name" value="AML1_Runt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008967">
        <property type="entry name" value="p53-like_TF_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012346">
        <property type="entry name" value="p53/RUNT-type_TF_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013524">
        <property type="entry name" value="Runt_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11950">
        <property type="entry name" value="RUNT RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11950:SF31">
        <property type="entry name" value="SEGMENTATION PROTEIN RUNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00853">
        <property type="entry name" value="Runt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00967">
        <property type="entry name" value="ONCOGENEAML1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49417">
        <property type="entry name" value="p53-like transcription factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51062">
        <property type="entry name" value="RUNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Runt" evidence="6">
        <location>
            <begin position="96"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="306"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="467"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="17"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="308"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="339"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="467"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAG5092148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="496" mass="52059" checksum="07DF6BC7786D1D9D" modified="2022-05-25" version="1">MDIFGRCNGPGSGGTTVTGTTSIRSGTVVPSSSVASVADSSGGVSASESAEGPGSTSRMQLTGASAPGTAASPESGVSPLADAYTKMTTDILTERTLGDFVSEHPGELVKTGSPHLVCTVLPAHWRSNKTLPVAFKVVALGEVGDGTLVTVRAGNDENCCAELRNSTALMKNQVAKFNDLRFVGRSGRGKSFTLTITVSTSPPQVATYTKAIKVTVDGPREPRSKTRTPFFASPLVDSLQPLPNPLQPLPNPLQPRDPLSSFRHAMPGNCQNMSQFGLTTGNSWGYGSTAGYAGYLPGPLSSCAAQAPFPPPPPPPPAPTTALTTFSGASMTPAAPDSTAGSTVTNSSRTAQQDAFSTVSSRKFGNSMLMTPNDYAKLVVLLVPVVPDTTTPGQTDPLDPLSTLMSGSTQRYQDYVSPRSLSTDSNTTDSPVHEEGFGQNYGNYFPTPGVLPSILYSQIYGNQFQNSDNSEQTSVAESCNVRQEEVRPDNNVWRPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HD81</accession>
    <name>A0A8J2HD81_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Similar to RpS15Aa: 40S ribosomal protein S15a (Drosophila yakuba)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HICCMSTLAB_LOCUS5404</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5089857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HD81"/>
    <dbReference type="OrthoDB" id="10250260at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.30:FF:000001">
        <property type="entry name" value="40S ribosomal protein S15a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.10:FF:000002">
        <property type="entry name" value="40S ribosomal protein S15a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000630">
        <property type="entry name" value="Ribosomal_uS8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047863">
        <property type="entry name" value="Ribosomal_uS8_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035987">
        <property type="entry name" value="Ribosomal_uS8_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003115">
        <property type="entry name" value="PRK04034.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11758">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S15A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00410">
        <property type="entry name" value="Ribosomal_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56047">
        <property type="entry name" value="Ribosomal protein S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00053">
        <property type="entry name" value="RIBOSOMAL_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAG5089857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="130" mass="14787" checksum="BDB2EDCF2A11C146" modified="2022-05-25" version="1" fragment="single">MVRMNVLSDALKSINNAEKRNKRQVLLRPCSKVIVKFLTVMMKHGYIGEFEIVDDHRSGKIVVNLSGRLNKCGVISPRFDVPITDIEKWTNNLLPSRQFGYVVLTTSGGIMDHEEARRKHLGGKILGFFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HDP5</accession>
    <name>A0A8J2HDP5_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Similar to Eps8: Epidermal growth factor receptor kinase substrate 8 (Mus musculus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HICCMSTLAB_LOCUS7373</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EPS8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5094047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HDP5"/>
    <dbReference type="OrthoDB" id="4680325at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035023">
        <property type="term" value="P:regulation of Rho protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007266">
        <property type="term" value="P:Rho protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01210">
        <property type="entry name" value="PTB_EPS8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11764">
        <property type="entry name" value="SH3_Eps8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000289">
        <property type="entry name" value="Epidermal growth factor receptor kinase substrate 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000183">
        <property type="entry name" value="Epidermal growth factor receptor kinase substrate 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039801">
        <property type="entry name" value="EPS8-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055093">
        <property type="entry name" value="EPS8_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033928">
        <property type="entry name" value="EPS8_PTB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035462">
        <property type="entry name" value="Eps8_SH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013625">
        <property type="entry name" value="PTB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041418">
        <property type="entry name" value="SAM_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12287:SF23">
        <property type="entry name" value="AROUSER, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12287">
        <property type="entry name" value="EPIDERMAL GROWTH FACTOR RECEPTOR KINASE SUBSTRATE EPS8-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22975">
        <property type="entry name" value="EPS8_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08416">
        <property type="entry name" value="PTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18016">
        <property type="entry name" value="SAM_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-0675">Receptor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SH3" evidence="8">
        <location>
            <begin position="521"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="163"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="253"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="419"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="461"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="607"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="19"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="166"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="176"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="259"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="475"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="638"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="663"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="674"/>
            <end position="693"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAG5094047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="939" mass="106279" checksum="98F5CB1C7C378576" modified="2022-05-25" version="1">MPYYNSGHSSSPYSKDVPSGPSNSSGSRSGGTEPTYMMEHLATFTVTKDTGIVYPADGMRRLLQLEKSNGIWSQKMQLRLERNWVLIMDNETGAVMERFPAALIQEPTAFTSRDPMEMYNNILVFTVGDDSGSGQRAEMHIFQCQSISAQDLVEDLKMLQMGKLVPGGSPRGPRGQIPPPPALPPPEPPLNGVNVREQVSAFNANGPNDREENNDEVSSTSSEKYERDVTILNHCFDDIEKFIARLQHAAAASRELERRRRNRKSKKRNLGDGMLTMRAKPPPEIEFIDIFQKFKLSFNLLAKLKAHIHDPNAPELVHFLFTPLALIVDASHDTNYDTNLPSKVVSPLLTREAVNLLINCVTSKETELWHSLGDTWLVPRDQWKGHVPPYHPIFMDGWSPEYPIPEDRDHDHLASLLNADKQKRDEIPEQQTDNYYNHRDVEESHYSSDYLEYESREERGNDYFDRNYGPGSELYSREDRERVDQTRAHSDISVDSIERGPRGTPATDRAQEAWLDDLLAKGAKIVQVTYPRTANNDKELTVVRGEYLEVLDDTRNWWKARNSRGQVAHVPHTIVAPHNQAHAGDNDVFNNPLYTSRYQRQGHGYNYEDSEIEGTSTSPGPEATHRPHTIPPPAPADWVRKERLGKKEEPKEEKKKQKTHGIVPPPPPLPSPSAPEVSSISSSKSGTLKSNSSYTEENGKDQMHKELKYVLTLFRDKKKHLDVVKTPEIFIDQESMPSEVQNWLSAKGFSDKICKQLKDMTGSELFSLTKRQLEQYCGLVEGRRLDGQLTLSRNASGYHTARTHELKQILEKARKKVEETSNPPALRPPGGLFTRIQARRASSISSYLKNIKINSLNMSIRRDNSLAVRVPNNNVSIRPYSNNSLSRIQIEYFSSICTCNSDESHGIHNTSMDTLFPNNRHPILDSVDAVGYFGKVIFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HE14</accession>
    <name>A0A8J2HE14_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS7861</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5095744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HE14"/>
    <dbReference type="OrthoDB" id="5359219at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032589">
        <property type="term" value="C:neuron projection membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050808">
        <property type="term" value="P:synapse organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000129">
        <property type="entry name" value="CLUMA_CG018772, isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013106">
        <property type="entry name" value="Ig_V-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037448">
        <property type="entry name" value="Zig-8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23279:SF37">
        <property type="entry name" value="DEFECTIVE PROBOSCIS EXTENSION RESPONSE 13, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23279">
        <property type="entry name" value="DEFECTIVE PROBOSCIS EXTENSION RESPONSE DPR -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07686">
        <property type="entry name" value="V-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035251755" description="Ig-like domain-containing protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="2">
        <location>
            <begin position="56"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="2">
        <location>
            <begin position="156"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5095744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="297" mass="33134" checksum="CAAC3C7736EFCF9A" modified="2022-05-25" version="1">MKILVFSLLLNISIQTNFPSVTVTAEMLQQRLGVNSIDKSSTSKPISDIDLPPTLPMIFGTENSSVIFAQSGSIALLPCIIHNLGDGTVSWIRRKAVQQLLTVGLSTYASDGRFQAIHFHHNEDWTLQIKYVQSRDAGIYECQVSTHPPTSIFLFLEVVEASAEIDGPAEKFVRPGSTLQLHCQVKKSTEVPSYLFWFHNFRMINYDVDLGVNVSTDLTNRESWLYVPRALDRHSGNYTCKASNAQPARVYVHIFNGDNPAAMQHSLASTRSTFLATLAWLIISAVQTSIDSQLRIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HE70</accession>
    <name>A0A8J2HE70_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS7966</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5095954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HE70"/>
    <dbReference type="OrthoDB" id="6367309at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="74"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="215"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="344"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="389"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="466"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="927"/>
            <end position="961"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="32"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="91"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="243"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="278"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="292"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="312"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="345"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="412"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="466"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="487"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="504"/>
            <end position="515"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5095954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="1008" mass="113248" checksum="86421649AFD9ECFC" modified="2022-05-25" version="1">MFGTKLRTWMEAHIVRPKKKKDRKKGEKGFDSNCNSPGSHSNRSPSGLHQVYPLNSPVKNVDNIIINNGSTTTYEGATTNSSGTSGGTGSVNLSSPESAYSTGYSTDGTSPGASYPPEYYINIRTGTHYFQSNKGARINKRPGEATSVMVNGPVNEVQRECVENVRVNGNINMTRENKLIRELKTTIPFQLQRHGGEFIHIEHNTGVVKATILPSSIPPPLISSPSAQSPRQRSRIRTNPWLSANSSGSSTATTTTTATTETIANGYNKSRLTHDETSSSSGLKLTESSGSASDVNINNHRNGNTKRECRQESLSAGRSPINQNWRISPAMDVRAKISGLLRRVSSSSSESSSMTQSFRSSEDDITLNEMMGKFDESYIYEKETDILSDSDPTDCEDYVNHSPSDIDTGQDGGDENDPLENDELDYIDNGSFLDLDNLEAHLPNTGHCTYFTFTTELTRRSTRLRESLLKRRSKDEFQHRTSSMRNNSKRQSLRHKKFDDKSGEKRKKRQSQRKKSGLEKCDDATANLNRVLVERMLLKNSGFNQGSRSVGGTPICLRRRKHHDINENLSSLKQNEDHHRNFIHPSVMDNDVVKRRSNSVSYVNGNTLKQRTSGNSRMSTFASELALIEADREADRKYRELIVEAENILVNMKNTTTTTTTTATATTNTRNTSPVIPSPSRRLHNGLANKRVELIKNTELNIELALLKSRNSQPELQSGSIRDIEHTSPKRQFNQPFSPIHRFIERNSGNLIKDNYHYRQDIKSSESPVVLRRTPQPSPCRSLVQNRVLMMEQETKDRSRSRGIEMNGIRSFSQDGRLSKTFTREQALSLAQKTSSLIIKKEIPRKTKEDTLTSSSSESDDRCELSRAPLMTFRSIDMGPVKESTYYCPQSEPVKRKVYAGSATYGRIQKTLGEHVVLRNSDGDTATDDTDDSRRTLREKIAQLRQERLAAEANLNAQDNQNFQHHLTQLRRQMLMHTIEGLKRSLEDQSATLKQTCLQEPILDDTLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HER7</accession>
    <name>A0A8J2HER7_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Similar to Myo15a: Unconventional myosin-XV (Mus musculus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HICCMSTLAB_LOCUS6992</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5093666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HER7"/>
    <dbReference type="OrthoDB" id="8182952at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009887">
        <property type="term" value="P:animal organ morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030182">
        <property type="term" value="P:neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd14473">
        <property type="entry name" value="FERM_B-lobe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13201">
        <property type="entry name" value="FERM_C_MyoXV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.530">
        <property type="entry name" value="MyTH4 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019749">
        <property type="entry name" value="Band_41_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019748">
        <property type="entry name" value="FERM_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000299">
        <property type="entry name" value="FERM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002404">
        <property type="entry name" value="IRS_PTB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041795">
        <property type="entry name" value="MyoXV_FERM_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000857">
        <property type="entry name" value="MyTH4_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038185">
        <property type="entry name" value="MyTH4_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051567">
        <property type="entry name" value="Unconventional_Myosin_ATPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22692">
        <property type="entry name" value="MYOSIN VII, XV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22692:SF26">
        <property type="entry name" value="SH3 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00373">
        <property type="entry name" value="FERM_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02174">
        <property type="entry name" value="IRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00784">
        <property type="entry name" value="MyTH4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00295">
        <property type="entry name" value="B41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00139">
        <property type="entry name" value="MyTH4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50057">
        <property type="entry name" value="FERM_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51016">
        <property type="entry name" value="MYTH4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="MyTH4" evidence="8">
        <location>
            <begin position="654"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="domain" description="FERM" evidence="7">
        <location>
            <begin position="813"/>
            <end position="1122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="130"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="186"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="292"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="369"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="418"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="130"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="235"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="296"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="314"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="381"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="438"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="475"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="490"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="533"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="562"/>
            <end position="573"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAG5093666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="1134" mass="130811" checksum="6E1938BB49D3369B" modified="2022-05-25" version="1">MYREVSDVEGVFSRRMSSNWAELPQTLRRRQKHRPEILNQFTDNFDSQEPEFRKNESQPPMDVRRIVKRSEFLRKFEMNESEHKNDSCWDQRSEKRLIYNDYKKTDFGPKFFSRVNPNFPSMMIRNEYRSLSDEERKTNSPDSLLVKSSDSDSSSDEYGHTDDSGAFLENDKLNAGQIGQRGRIAKLFSREENTKKSSSKVNSSVKHQEQISNRKSSSSESRKSVKDAQLVTNKSSDHLEESRRSTSSYEYENIPRIDVSKVLGEQPKTRGTNTDRRHPTIEELRMEVGCQLRSRNSYEPRQENHLRKISLQGSNSPVSLSSSSPPGYYSNNINNNNNNNNNNNNNNCNRSSMEELRLEGFIQDMCKMEQTNNNSNGNRVNGEKKKSKMETITEEKQDGSKLSVREILKRFEELRMQNEAQQQQQQQQVEEKEKSGDKTLTTIQETLQKLDEKVKRSSNQVDQKPQHKTHHENHVSQITKSIQSQPSYGNNNSNNNNNNNVSHNNQIHNQSNHVNRETNHSPVNRVPGGHTSPIVQANGGSNHNQKNHRNSQHHGGQNQEWRQPEETNNKSPEEEFYECGPVVNDGKHSLLQYAMLNFRQSTEKFEMMKTADGSISGSLKVIESLKNKKKSKKNKGQQDGAEWTWKEQVDLVKFSPVPIEQSLLRLDTELSSLAVECFLCLMRYMGDQPLPPDMSEVKCVYTILMHCHKFEPLRDEVFCQLMKQTTNNKSPNPDSCQRGWRLFSIVAAYFTCSEGLRPYLIKYLETAAYDKRRAYHGTATVCLQNLRKTVKYGGRKNVPSVEEIMAISAGRNAKRQIYRLPGGTERVINTKCTTVVQDVIEEMCSVISVRNPHEMDEFSLYCIVDGDAFTMPLARDEYVLDVTTELQKNHQVFYLIFCRSVWYYPLRLDAALYIEVVFNQIAPDYLEGLLLVIPEDHLPQEVIYDMAQIAALLHRAADMAHDPSTKEIKYLLPKPALSLREPKPQQWGSMVQQAWNNIQHNTPAVCKAQVLEILSKWPLFGSSFFAVKRIPENGKEKGGDHILALNRHGVHFIDLMTHVTLYHYPFSEVISTRKVKSEEGALYLDMKCGNLMQQRITRLQTEQAHEISRLIRQYITMEQRTTNNQTTGLSYGWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HES4</accession>
    <name>A0A8J2HES4_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS8344</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5096706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HES4"/>
    <dbReference type="OrthoDB" id="6260541at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005911">
        <property type="term" value="C:cell-cell junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22249">
        <property type="entry name" value="UDM1_RNF168_RNF169-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028842">
        <property type="entry name" value="Afadin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10398">
        <property type="entry name" value="AFADIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10398:SF2">
        <property type="entry name" value="AFADIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="101"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="382"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="468"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="582"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="167"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="7"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="31"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="56"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="111"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="394"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="416"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="582"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="595"/>
            <end position="607"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5096706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="721" mass="82458" checksum="564403A5F9C4CBBA" modified="2022-05-25" version="1">MFNPGYSRTSSSNSTTPPVQPPPMPSMNGASSLRSRSSNNLHEPTKMSHLPLSGLMNRQRSSPNLNPSQSFGNALNNIQNNEAERFYQNLSVYRHQDPTVKQLGPYHTSVDRNSMYTPKQLKGSQNSLNHPIFDVNQGKDRPLSAYVSPDQMNYNAYQIPQAGSLLKTQSSRDIIRQEAKLQEMKEEVRRRELRAGAIISSQHQTNSLNMRPTTSQTNIGIYKQTSLVPNLDLNSPTYNTIQISSNYGSSDPQHNQYILYNKQLISNQYTSISKKNDASCSNQQITELDKEYDADLSRPITEYNQQLGLFNKPQFLNDSSNVNHQRNMNENSSNQMHYENNINKESLPLHSILEKEYKERHPPPPLNTSTHPFNMKQIDSRYTSGGQEVPKGSYYSTTNSSQQNRQHQYNATNPWQREEREKEQARRREAAKLWRDQQIAELNSLSHRTQQQEEQLRALQLERDFQKRAEEAAAQQDDDEESNDLDNQNIPCVQGLLKMAATPEKNYPSIQPNTLSRTNLANQSIRGTNSSQSASHQLKLPFNSLPIVTSQQDLMKYGNIHEEQERNQRMDEYKDEEIDYDGNHRKNEEDTKHSQQQYQQNQTNPKNQQQLYTEMLKLDNLYINDGNEAPVPPERGSSYTVMSQQNVLRSSSAATISSPIGSHQASIKRVSFHDSNANIENFSKNSIISNLSSPYSMGTIKEDSNYPISLLKIRYLRDGTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HEU3</accession>
    <name>A0A8J2HEU3_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">acid phosphatase</fullName>
            <ecNumber evidence="3">3.1.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HICCMSTLAB_LOCUS6239</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a phosphate monoester + H2O = an alcohol + phosphate</text>
            <dbReference type="Rhea" id="RHEA:15017"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:67140"/>
            <dbReference type="EC" id="3.1.3.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the histidine acid phosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.2" evidence="3"/>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5092584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HEU3"/>
    <dbReference type="OrthoDB" id="5821688at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003993">
        <property type="term" value="F:acid phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07061">
        <property type="entry name" value="HP_HAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033379">
        <property type="entry name" value="Acid_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000560">
        <property type="entry name" value="His_Pase_clade-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050645">
        <property type="entry name" value="Histidine_acid_phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11567">
        <property type="entry name" value="ACID PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11567:SF211">
        <property type="entry name" value="PROSTATIC ACID PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00328">
        <property type="entry name" value="His_Phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00616">
        <property type="entry name" value="HIS_ACID_PHOSPHAT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00778">
        <property type="entry name" value="HIS_ACID_PHOSPHAT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG5092584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="398" mass="45742" checksum="5B937E079AAE1792" modified="2022-05-25" version="1">MNCKYYCKMINVRLVFASIALLGAAGALSIGRGDGDQSQGEKDQSTLRQVTMLMRHGQRAPVDTYPTDPHINSTMDPYGWGQLTDKGRLVAYNEGLFLRDRYGEFLGDDYSPDKFWLQSTSADRAKMTAMILSAALWKPNEKQKFKSGVDWQPVVLHYWTRPEDKLLIIWNACPKLTVERVKVDHDPAVREINMKNQDMYAYVAEYSGLPMKNPGDIANVYGTLVSEERMGMKFPEWVHKYYPRKMSPLMVFSLKQNVWNDKLRRLSGGPFVTKMVNKMEDRSTGKLTPKSRKMYAYVAHDNTVVNMLSTMGVWDEKEPGFNAMVLVELHEIKGQWYVQLFYRNAPDYETRPLTVPGCEHQCPLEKFKELMAPMIIDNYEDECKVDDPNYEIPPAPPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HF89</accession>
    <name>A0A8J2HF89_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Trypsin-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HICCMSTLAB_LOCUS6976</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Extracellular space</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase S1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5093641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HF89"/>
    <dbReference type="OrthoDB" id="6755574at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000068">
        <property type="entry name" value="transmembrane protease serine 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000036">
        <property type="entry name" value="Trypsin beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050430">
        <property type="entry name" value="Peptidase_S1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033116">
        <property type="entry name" value="TRYPSIN_SER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24276:SF96">
        <property type="entry name" value="PEPTIDASE S1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24276">
        <property type="entry name" value="POLYSERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00135">
        <property type="entry name" value="TRYPSIN_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 7" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0720">Serine protease</keyword>
    <feature type="domain" description="Peptidase S1" evidence="8">
        <location>
            <begin position="12"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAG5093641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="246" mass="26962" checksum="AE95723E5923BEB9" modified="2022-05-25" version="1">MLTIYGNEPSRIYGGENSKVGEHNFFVSLTEDERTFCGAAIIDDRHVITAAHCVANFTDIDVNNTAISINITDLQIGGQNYSIKKIFIHRNYNETDPASHNDVTICRTNETMQLGANQQKSVFALPIALASGPTESGKNVTVVGSGITESYPKYLSETLKKLSVKTLAISECQKYFEDKLWDGQICTISPIGKGTCLGDSGGPVVNSEGELVGIISWGMPCAIDYPDVHTNVSYFIDWITDIINYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HFK0</accession>
    <name>A0A8J2HFK0_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS6679</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5093229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HFK0"/>
    <dbReference type="OrthoDB" id="6509516at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579">
        <property type="entry name" value="F5/8 TYPE C DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579:SF1">
        <property type="entry name" value="F5_8 TYPE C DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5093229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="554" mass="64861" checksum="A26CAA84550A37FF" modified="2022-05-25" version="1">MSKNIKADVTCSGCKKKYKTSKKKGNFFVTVDLKTQLDNFLSSESMREEIHNRNNSHRDDCISDVCDSDRYMNDKYIQSKSDEENVVLTLNVNLDGAPLFKSGKNSFWPIQCVINEISQKIKHKFMLLAGLSYTATEPKPQFMNLYLDTFISQVKELTKTGLQVLAENGRIITYYVKIFSFPVDSVARPVLQNRLQFNGFFGCSWCYQRGKTSSKSLKYSLSSENPPLRDHEMYLTDVEQLKKDLETLPKTKKNEKYTVFEVKGSSVLSNLPDFDCIWGYPHDYMHGVLLGVERQLWNKWSKDYLSVDQRKLVNARLTTIQPTNEIHRTPRVLLKKQSWKATEWRSWLLFYSVPVLSGILRQDLLDSYKLLVKSPNGVMGQMANRTLRYNNFQKMLFEESEESCREFCEQILNKRRENVYKSEKSEDGALMMDYLRDHEFKISGRYYNRCLFKKTMYHCVLYTQAQKTNNSFIRLEDGRMAKIVQFLLQNKKAFMEVQILSVAVVENFEHLWMIQNYKSDVIRLPITKIQNKMIYIAIKALSCSEENKDYLSVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HFR0</accession>
    <name>A0A8J2HFR0_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zinc finger CCHC domain-containing protein 7</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">TRAMP-like complex RNA-binding factor ZCCHC7</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HICCMSTLAB_LOCUS6787</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5093397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HFR0"/>
    <dbReference type="OrthoDB" id="7541924at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031499">
        <property type="term" value="C:TRAMP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071031">
        <property type="term" value="P:nuclear mRNA surveillance of mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071039">
        <property type="term" value="P:nuclear polyadenylation-dependent CUT catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071035">
        <property type="term" value="P:nuclear polyadenylation-dependent rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071036">
        <property type="term" value="P:nuclear polyadenylation-dependent snoRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071037">
        <property type="term" value="P:nuclear polyadenylation-dependent snRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071038">
        <property type="term" value="P:TRAMP-dependent tRNA surveillance pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051644">
        <property type="entry name" value="TRAMP_AT-DNA-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46543">
        <property type="entry name" value="ZINC FINGER CCHC DOMAIN-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46543:SF1">
        <property type="entry name" value="ZINC FINGER CCHC DOMAIN-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="11">
        <location>
            <begin position="403"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="11">
        <location>
            <begin position="449"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="339"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="471"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="30"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="71"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="86"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="116"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="126"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="339"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="371"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00041190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00043023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAG5093397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="559" mass="62420" checksum="5CE2B105B14ABEAB" modified="2022-05-25" version="1">MSDEEKSKSYSLRKDGYVPFPEGLPPVTRKRNETKKFEFRDAFDGEKTVDSGLGKSQINPEITSDEDSEDEPRKEIPRADKSDTASTSNNNIDLTINNDDTLTEKTVSVPVDKKTVNTPVNQEKVNNPIDPGNNNNNNPEDPNNIDEMVLTANQSISLSDALAFVPRFDGVPEELIDFSKCCKEAKDVLPAKAEANLCKLIYGVKLDDKVKASLSHTIPATILDLTKNLKKIYVASKTVFQLQGELGQLYQGKGESVVDYANRLRKKVDEIIECNASDNPNMTEEENRAFKDKINSSLAAIFTHNLDQEIEQRMPICANVDEALAAAITIERKMKARNELMSKPKEKTAEEKKKKNPVTFTTTTDSRNPKNKTSNSGNNNNPNKNTNNGNGNSNQFDLSKINCRRCRKQGHFAKDCPERQCQICYEKGHGAKTCPQLAKTGQNQYANLRCQLCGQRGHSARYCKLNLNQVNPASNPEPSQGNYRHPPNTGNNNYAQNAGMHCDVCGLDNHTQENCRWLKTINFIQANARQSSSGGAREDHRNTRPVHAIQNVRIDEDSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HFX6</accession>
    <name>A0A8J2HFX6_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similar to GBA2: Non-lysosomal glucosylceramidase (Homo sapiens)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS7398</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5094072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HFX6"/>
    <dbReference type="OrthoDB" id="730489at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006775">
        <property type="entry name" value="GH116_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052566">
        <property type="entry name" value="Non-lysos_glucosylceramidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12654">
        <property type="entry name" value="BILE ACID BETA-GLUCOSIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12654:SF0">
        <property type="entry name" value="NON-LYSOSOMAL GLUCOSYLCERAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04685">
        <property type="entry name" value="DUF608"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycosyl-hydrolase family 116 catalytic region" evidence="1">
        <location>
            <begin position="2"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5094072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="241" mass="27515" checksum="0B029E979AFCC83E" modified="2022-05-25" version="1" fragment="single">MINAYPIHNICNWKDLNSKFILTTYRDFILTGNQDMLKDFWPSIKEVLEYSLAWDTDQDGLIENSGFPDQTYDTWVMNGPSAYCGSLWLAALCCSLEIAKIFNDTQFIKKYTEILKKGKDAFQDKLWNGKDGNQGAVNGFLPSGRIDTMTLQSEEMWTGVSYALAALMIHEDMVEEGLRTAEGVYRTVWEQIGLAFQTPEALYEKGGYRSVGYMRPLSIWAIHQAFTYKKQISSDVDDTKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HG16</accession>
    <name>A0A8J2HG16_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Coagulation factor XII-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HICCMSTLAB_LOCUS7960</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5095942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HG16"/>
    <dbReference type="OrthoDB" id="10002959at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000006">
        <property type="entry name" value="Serine proteinase stubble"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050127">
        <property type="entry name" value="Serine_Proteases_S1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033116">
        <property type="entry name" value="TRYPSIN_SER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24264:SF54">
        <property type="entry name" value="PEPTIDASE S1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24264">
        <property type="entry name" value="TRYPSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00135">
        <property type="entry name" value="TRYPSIN_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 5" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0720">Serine protease</keyword>
    <feature type="domain" description="Peptidase S1" evidence="7">
        <location>
            <begin position="424"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="87"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="178"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="328"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="90"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="178"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="338"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG5095942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="665" mass="75058" checksum="8FDFFD5C115FF081" modified="2022-05-25" version="1">MMLLRFIARKSIAQNDKYAVFEAAIVVFVFNFIVEIQGRNVYGTELGDRPQEQFAYSRSRSFSRDQFFPVVRKRLSIDRYFDGSDDFSGSNNHNNNNNNNNNNNNNNSNNNINSRIEKKEIRRTQKNDVQRLTEFKNKPQSKLIEEEFTDVQIEKLQNFGEDDDTKNELEKLLDELRGSDGSKIEEQSSERGRRGRRRKLSSHEQGILLVETLKKKKNYTSYDDHRGHAANLNSGIMDMLGRMIPQTCKYKGAKFECGLSISCVLSGGRPVDLCSGGLIWSCCVDDDDIPEKEPSRPTSGVLQNATFSMILGNQRPYVEDDVKIYGNGLAQRPHRPNSHQSGDNSGLYGSTYSAWEQDRPNDLSSFDRPNYASHPDTSYPNNFYPDDDYNTRPVVGGTEDYQNNAQDQSKYRGCGELYTRSNRIVGGHSSSFGSHPWQAAIIKSGFLTKKLSCGGALLNNRWVVTAAHCVATTPNNNLKVRLGEWDVRDGSEKQLHEEYNIERKEVHPQYSPTDFRNDVALVKLSRAVAFKQHIVPVCLPARNLKLSGRTATVAGWGRTRHGQSSSPNVLQEVDVEVIPNERCQRWFRAAGRRETIHDVFLCAGYKEGGRDSCQGDSGGPLTMAVEGRHVLIGLVSWGIGCGREHLPGVYTNIQKFVPWIDKVMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HGD2</accession>
    <name>A0A8J2HGD2_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to NOL4L: Nucleolar protein 4-like (Homo sapiens)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS9269</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5099857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HGD2"/>
    <dbReference type="OrthoDB" id="6371073at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056549">
        <property type="entry name" value="HTH_NOL4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039788">
        <property type="entry name" value="NOL4/NOL4L"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12449">
        <property type="entry name" value="DEATH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12449:SF22">
        <property type="entry name" value="NUCLEOLAR PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23079">
        <property type="entry name" value="HTH_NOL4_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nucleolar protein 4 helical" evidence="2">
        <location>
            <begin position="126"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="238"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="263"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="265"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5099857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="461" mass="49971" checksum="9A150DA1C73CB85F" modified="2022-05-25" version="1">MATLSRDTLVDSQNASQYLGLNSRNGTSELGELSSGVPNLGAVAGVGGEDMASLWASYAMGLKKTPPPASSCTPSRSDRDRESSPTGGEGAGSAQDETSSSGNKEDEDDDDEDVDERLDPRHHDPERLKAFNMFVRLFVDENLDRIVPISKQPKEKIQAIIDSCTRQFPEFAERARKRIRTYLKSCRRNKRGREGAPWDAARPTPAHLTSVQAEQILATACENESDNAKRMRLGLEPVSQPMPTLPAATQQQHRNRQQLCDYAEDEQRQQTDVRSSLEHFASTPIKSLPGKREDTPPTSMTSLAPLTSLASLPNSTLASTPLSLAPTSKLLTSTDNKGLMSQATIVSSSAVNGVASGGAPTAMYRPNFSQAFQRAGPTNVPPTLSAGLYPTQSFTSGLLSNGTQRPTDLSMKNTKPLLSHKLNATEMTAVRQLITGYRESAAFLLRSADELEQLLLQQPPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HHL2</accession>
    <name>A0A8J2HHL2_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to Nup188: Nucleoporin Nup188 (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS10273</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5101200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="102511at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044611">
        <property type="term" value="C:nuclear pore inner ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006405">
        <property type="term" value="P:RNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018864">
        <property type="entry name" value="Nucleoporin_Nup188_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044840">
        <property type="entry name" value="Nup188"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31431:SF1">
        <property type="entry name" value="NUCLEOPORIN NUP188"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31431">
        <property type="entry name" value="NUCLEOPORIN NUP188 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10487">
        <property type="entry name" value="Nup188_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nucleoporin Nup188 N-terminal" evidence="2">
        <location>
            <begin position="55"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1646"/>
            <end position="1668"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1871"/>
            <end position="1891"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1652"/>
            <end position="1668"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1882"/>
            <end position="1891"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5101200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="1935" mass="220696" checksum="408928A1AFBDADD1" modified="2022-05-25" version="1">MEPLGNVPYCKGLWSVISSTTSRCEKALVVEEIKNATELLKEGLIFFKPFTESSLEKVQKSNPGPRMLDLVSKLATFLNLDATIAWDLTLNYMIYEYRNSGETFASHLADITSMKVLIEDIWTFYYSERITLIKCLKLIIEYRDNKRHPYQSEFSEFFKKASLESILESSLKQIDRLKSASIANRSHLLTDDHLHKLYNSTLVEMRELLHIVTMLLDTVQPSDFQNIYESVCGEPRRLAGTKSHEDKEKITKQLEEIRHCQIALFVVALDVTKRYENSASSDEVYNWVERLRENIQELVEPKCRRDGSPEDGPLLLVWMLVNFAVEPENSELLNRFRPCGVRAVQLDVFRTLQSVLDSEVINESTRYAQVVRTSIYNLLSLLCSFVDEDRLSNFEGIFDVVASILRYPETATEFWNDRNEEGGLWPLFHRAVSLFPYRFEPLTRIATGLANASLPSAKKIAARLEELDSVTLEEPIHRNFTPNAGPRQPYRPYEKECTLHRNEFTIPDNCERIVLDSDKEIVLWRTKSRYGDAFHYKIELLFYYAGSGIMNVVNQQTSLPEHVTLGFTLLEALLASDVDLPLGMVIPTELSLEVINRFCHSILPRSLYLLVAACCRVTSKLALKYPDEIFTRMRVGIYPKFNDWYQDIKELARAFSFDGGLVASWLSGIETIEHRYPILNAYLDTLYNYLVSKHSEEAMYNMEIPGMVFLLQGVLPKLDSWYFTSETERIELWLKSMSCIHHALDVNLPKNDPRKKLQLVVAYSLLYLEPRHALLKLVRTGERNLRNQMMNESDWISGKGFKVIESVRLALSLVNRLLMFRQSLGLSDDERSPLEVALYTSPSLPTGLLIVPTIVNYLYVEFSPSLQAMAVSLLKKFAQGFSMSLLVCMGMDGTSIRVTFASRLMSPTCSAKVKVTILELVAVCLERQPGLTEALFNIMHQAEQKRMFPKSADQFLTEGCSHFIELYLERISKEKEIVYDKLYDNTMNLIRAIWYNRNTILVNYFRKREKFWNQMFAPLFRPLVSGSRGYAYLIDIATLELFESAPPLLPENDFTKNLEIFLYKDNHWERFIEYILANPASTMDTDSKIEEENNSSNESPLYEANIEAWYHFIVTLTDNKVSSELMTQMEASRVQFMMRYTLDSLSLRIKRTKTIGDARITMLLASLALRCVFTWKLKCVDEQQAFISRIVQLMEDIFHSYDNYGAGLRRILVSLLLGCIQLVKSAMAEDKASLEYLLIQSCLLSNIELRKLSDAVKKTQEVQAASGNIKHVVEEENDIIDGKISSDSTKSTHTSTPATLTISMVTQLLQCINQQDPLKYGNRSVCLHLRQLAPDLMSCLSTCLQSHRYVGFSRAGLELLGMLARSTTYNPPPRPIDEQESIAKLWLALVPPESLRNSMLECLYDDRTCQGQWRCQDWWMIYTLGLEFITGLIMSSIGFGGQSSCQSTYVTSVVIFLGSHENQLTEVATLLRHTADPRAIDLVQSLVALISALTMRTAVWEMIQPSVREGLMNCMYLIYDSTVNLLLRPRILKFIIDGVSVESAEDLHWCDEKLPSNELKLVVNKLIVINWWCAQCFVRFSPRLNALVDTIYTQNFWHTPLAEINFGPPQMSINSGPSLTYGTIISSTQLFTQALNVHLAINSSPKTIQRTPSKDGMDSAKREWERSTPEYPRKIHPKDLRRVFNVSGPAHAYFDHSGYASSHGLLGNPRLLRRPYDPLICENTILSRTTPFSHHTRHVSKNGTQNQSVNVGQSIRVDANPWFDSMDKNNSRLALEINLVLVLCQTLEGVKSPRLALRDRQLIARETANEIGMFFDFLEQRASGLSDWDIQGALVGVGMNEASVKIIKPPVNVLTINAQLSNQSTINKAPVNAIEYNPGEGTSRDDDSQEKEVRLDDNIVSTGCYNISSYKIKFLSLLGKLFKSTLESLDSAQYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HHM7</accession>
    <name>A0A8J2HHM7_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HICCMSTLAB_LOCUS7871</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="7">Belongs to the DExH box helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5095764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HHM7"/>
    <dbReference type="OrthoDB" id="5600252at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002151">
        <property type="term" value="F:G-quadruplex RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd17917">
        <property type="entry name" value="DEXHc_RHA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18791">
        <property type="entry name" value="SF2_C_RHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000526">
        <property type="entry name" value="DExH-box ATP-dependent RNA helicase DExH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048333">
        <property type="entry name" value="HA2_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF257">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DHX30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21010">
        <property type="entry name" value="HA2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04408">
        <property type="entry name" value="WHD_HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 11" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="9">
        <location>
            <begin position="359"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="10">
        <location>
            <begin position="571"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1126"/>
            <end position="1161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="1126"/>
            <end position="1141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="1146"/>
            <end position="1161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00060772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAG5095764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="1161" mass="133962" checksum="CDA65E641BEABBA9" modified="2022-05-25" version="1">MLSCSKVLTKHGTFCNRAKSLAKDGHLQKHVSFIINKRLFDTNALSVTHKNVETIEKCRLTRTNQLDNRFIRMQSFCYLCSRNFHTNLLLSRSVIDDRVRLQSSDTKKPHSNININDLLKNHESKNYFEENVEEIEGENNNVHDIHHSRREKVNIKEVEKMYPHAKGKIHEIYQIVNNDMKKNTLSFEFKKPTGKKQHNWSCTLKVLWPEETSFTTIASNKSKASELASLKCLHWLENQKRLNKGMPVLYDSQGIKDLINNPISLSVKSETLNDAQTIIEKYNDYIKTLVDENTNKDNIKHRNFGTSEITDPVGRLDPINCTPEKLQERNRLLLARFEHRMSENNYCSLPILDFRKQIIEEVKNNQILLIKGDTGCGKTTQVPQYIMDSFAGYGEATNCNMIVAQPRRISAISLAERVADERKEQLGDVVGFQVRLSQQLPIRPARIVFCTTGILLRKLQFNPTFQGCSHVIVDEAHERTINTDMLLVLLKRAMKENPKLKVIVMSATINSELFQSYFNCKVIEVPGRTFPVQMNFMEEIDKLGLRAPSRWDLTFEDPEKMKEGPYVDIVKMGELVAWIARNKPPGAILCFLPGWSEIVALKKYLEEYSLLQKNKIAILPAHSKVAQWDQKKIFDHYPNNIRKIVLATDIAETGITVTDVVYVVDSCTHRQIRWQEKRGISSIDSHWISKANIQQRKGRAGRVQPGVSYHMITREQFQNLDEYPTPEVMRTSLEKTVLDIKTYTNEKAKMFLRSMPQPPAMSIIDAAVRDLVKLGALDHDENLTALGKRIALFTVHPTLSKSMVYSSIFQCIAPILTVASVMSSDSDIFAGVLHNKGFIRDVKAKYHPTSDHISVAWLFEQWNAYNKQGRFASRDFCVKNKLYPDRMYTLSRVRDLNAEHLAQAHMISDSIEYDNMKKSENEFAELDELVRGILLAGLDQVLYHRDFDIRKGQVKKGACTFIMEDNNHATILPDSVNFKRRYFPSPFLTYVRRTHSEQRRTSLIRETSMISPLTVFLFCQGKIIGNIETDNDIENVIFTVEDKKNVRLVCSKETAKVLLAFRDAMWSVVRYMVSNYGVVQTSNSETFEKVQAFKVEMLQVLAKMLSEASIHIDKPEPLKKEIIYSEDENEDDDQDQDEFEDNFDHNKHKYNNKNNNYKRNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HJI6</accession>
    <name>A0A8J2HJI6_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Similar to ZSCAN22: Zinc finger and SCAN domain-containing protein 22 (Homo sapiens)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HICCMSTLAB_LOCUS11620</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5103659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HJI6"/>
    <dbReference type="OrthoDB" id="3176202at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001217">
        <property type="entry name" value="zinc finger protein 319"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000145">
        <property type="entry name" value="Zinc finger protein 574"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23226:SF429">
        <property type="entry name" value="CROL ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23226">
        <property type="entry name" value="ZINC FINGER AND SCAN DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="310"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="338"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="366"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="394"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="190"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="255"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="257"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAG5103659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="517" mass="58164" checksum="68D85F2555E3191D" modified="2022-05-25" version="1">MNFSEQSGIQGLPQFSEITSRANFISSSNFTTTSAQLLGVQSSVYTTTTSSDSGKQNILTNHANKYPGSLLWSNSNALMQLCEKQALQTINIPNYSQNNSLLSVGGTLSNSLPVRLLPNMYLPTTSQPDTTVNVKQEDVNGDASNANISNNDQPHSMQQLQNAAMAEYFQKLQAGKLPLATLQQLIKIQSEPMKKDKSNDIEEERSEQPQNNILNIPCVPGFRNNLQNGNPYLNLDQLAGSINPTDLNIHIETDPMTSSSSSSTATAVQPPMKVEQQIQTDSPKTERKTKFRAKLGEIKIATSIDGSLLYCCPECNMFFQEKLDIDQHIQIHLQERKYQCKECGAMLKRKEHLDQHMRGHSDERPFKCLVCQKAFKRNEHLTRHFVIHSGDKNFTCNICQKAFSRKDHLNKHTQTHLGIRRGKSKKDAVPIEVKETIDPVGDALKHDLSYILKDGTFIKQEPASFLQHIQNLHKDQQLSQTFSAYKEQALKENGIHQQPAVNMNEILPQNTRYLMPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HJM8</accession>
    <name>A0A8J2HJM8_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 10">DNA-directed RNA polymerase</fullName>
            <ecNumber evidence="2 10">2.7.7.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HICCMSTLAB_LOCUS9131</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="10">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 10">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the phage and mitochondrial RNA polymerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="2 10"/>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5099582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HJM8"/>
    <dbReference type="OrthoDB" id="276422at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034245">
        <property type="term" value="C:mitochondrial DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001018">
        <property type="term" value="F:mitochondrial promoter sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071897">
        <property type="term" value="P:DNA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006390">
        <property type="term" value="P:mitochondrial transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.20:FF:000031">
        <property type="entry name" value="DNA-directed RNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.280:FF:000001">
        <property type="entry name" value="DNA-directed RNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.280">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1320.10">
        <property type="entry name" value="DNA-directed RNA polymerase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046950">
        <property type="entry name" value="DNA-dir_Rpol_C_phage-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002092">
        <property type="entry name" value="DNA-dir_Rpol_phage-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037159">
        <property type="entry name" value="RNA_POL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029262">
        <property type="entry name" value="RPOL_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10102">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10102:SF0">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00940">
        <property type="entry name" value="RNA_pol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14700">
        <property type="entry name" value="RPOL_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01311">
        <property type="entry name" value="RPOL_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51375">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00900">
        <property type="entry name" value="RNA_POL_PHAGE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00489">
        <property type="entry name" value="RNA_POL_PHAGE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="5 10" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <feature type="repeat" description="PPR" evidence="9">
        <location>
            <begin position="278"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed RNA polymerase N-terminal" evidence="12">
        <location>
            <begin position="423"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="106"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="189"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM01311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAG5099582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="1264" mass="145362" checksum="29E4684A9FD6A959" modified="2022-05-25" version="1">MYRLLKIPQVHLMCVSNSSQVYYNSAIKLCSYCRLEHSIHSTKKGILQIRLQSTINTVLVPSIPAKVKRKPKKYTELLEVTDSNVNNRKAAIRKMNASHLSLLVDKNGNKQSKRYDKNPSEKNPILLSTTSPIDINHDHRIQLNDVDNPHEELGIMEDLQSSGISDSASLIKNISTLDAIPEEHLKNEFEDEEHEEGILQNSKTNKRKSTKALQKELKLKKELGKWQVAKHQNELESTVRALKAYLNVCLNCNMMGRAYHTVMHYRNRSPQNHKKVREILIYNILLQAYASRGQYSKVHDLMEVIRKDQLVPNAQTYAAVYECFGNINVNLNKMQFLNKMYEKMKKSNITFDQVLKESRTKVNQYKNVLRGISLIDPNFVPKIETENESYSCQLVKKITPETATHNSPAGGLMELPDLMDRFASQIKSEMDGHVIIESIAKIDTSHSTVSSYRKEIEKLEENWRNDISLAFDRDLKALKKKEYHPIPSEMVLYPYLCVLNKEEYVNAVMHEIRKLANGSESFSPSFNLLRKRLGKFINDKYDILIKKQSKYPEILGNVYSKYGQWYLSCTNGQNSRENWHKISQEVSPNFSLELELSQWPTNLSRQIGKFLYKIILNDVKIDTNSTRLDRDSQDLRPAFYIVWRHNNRKHLVKEVKPHPTLAKIYRGSNPETLSFETNLLPSECPPRPWSSIHSGGYQLLKSDVIRVPLFAIEQIKRLEVTPPRQLWPALDCLNQLGSVPWNINKPVLDLAIKIFREGGSVKLNVPQPPSVLGSGPLLSQDSTPNERINSRRAQMELNRKKSEMYSLWCDAHYRLSLANHFRDKIFWLPHNMDFRGRVYPVPPHLSHLGSDLARSIMIFALGKPLGPRGLDWLKIHTINLTGFKKRESIAERLRYANEILDKIIDSAEKPLDGEMWWATSDEPWQTLASCMEIAAALKTPNPEEYVCRFPIHQDGSCNGLQHYAALGRDQIGAESVNLFPRDKPQDVYSNVAAMVDKLRAVDAENGLEIAKILEGFVKRKIIKQTVMTTVYGVTKFGARLQIARQLKDLDDYPQDKVWPGSLYLAQKTFESLRTMFESARQIQDWFTDCAQVITTINGKNMEWVTPLGLPVIQPYSKVLPSRNKFTDIATDLLLKPNTSKQKNAFAPNFIHSLDSCHMMLTSLNCEHTGISFVSVHDCYWTHPCSVEIMNRICREQFVALHSEPILQDLSKYFIDKFTCDEKKIDADNLEEILSKEKLHRTLSNVPKRGTFDLKKVLDSTYFFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HJP1</accession>
    <name>A0A8J2HJP1_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Similar to SRSF7: Serine/arginine-rich splicing factor 7 (Homo sapiens)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HICCMSTLAB_LOCUS9295</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5099909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HJP1"/>
    <dbReference type="OrthoDB" id="5970at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12373">
        <property type="entry name" value="RRM_SRSF3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000899">
        <property type="entry name" value="RNA-binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050907">
        <property type="entry name" value="SRSF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23147">
        <property type="entry name" value="SERINE/ARGININE RICH SPLICING FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="8"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="6">
        <location>
            <begin position="112"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="75"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="121"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="75"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="92"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="129"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="174"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="184"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAG5099909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="209" mass="23396" checksum="07E5C3F622D5C1AE" modified="2022-05-25" version="1">MSRYPSDCKVYVGDLGSNATKQDLEDAFSYYGPLRNVWVARNPPGFAFVEFEDARDADDAVRGLDGRTICGRRARVERSNGKRLMRDRGSRRGGGGGGGGGGGGRPFHPEDRCYECGERGHYARDCPKHRGGRKRRSFSRSRSRSRSKRSRSRSSSRSRSRSRSGRRAKSASKGRSESKDRSPPPRRSRSRSASRSRSRKSNGERNGKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HJR8</accession>
    <name>A0A8J2HJR8_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Similar to TRPV6: Transient receptor potential cation channel subfamily V member 6 (Homo sapiens)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">HICCMSTLAB_LOCUS9355</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5100042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HJR8"/>
    <dbReference type="OrthoDB" id="533508at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034703">
        <property type="term" value="C:cation channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005262">
        <property type="term" value="F:calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098703">
        <property type="term" value="P:calcium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000132">
        <property type="entry name" value="OSMotic avoidance abnormal family member"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024862">
        <property type="entry name" value="TRPV"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10582:SF2">
        <property type="entry name" value="INACTIVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10582">
        <property type="entry name" value="TRANSIENT RECEPTOR POTENTIAL ION CHANNEL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="13" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="8" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-0107">Calcium channel</keyword>
    <keyword evidence="4" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="12" id="KW-0407">Ion channel</keyword>
    <keyword evidence="10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-0675">Receptor</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="255"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="281"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="320"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="387"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="13">
        <location>
            <begin position="26"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="domain" description="Ion transport" evidence="16">
        <location>
            <begin position="258"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="817"/>
            <end position="938"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="817"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="832"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="871"/>
            <end position="881"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="891"/>
            <end position="908"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CAG5100042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="938" mass="103697" checksum="A9EEA011D2B25890" modified="2022-05-25" version="1">MGHKKFFHRQQQRVSRNTDYEGLAYLGEYPLAWAACCANESVYNLLLDSGANPDDQDSFGNMILHMVVFPASNGIANTAGFTPLTLACQLGRAEVFREMLELSAREFWRYSNITCSAYPLNALDTLLPDGRTNWNSALFIILNGTKAEHLDMLDGGIIQRLLEEKWKTFARFLKRLIILVFHLTSLSLAVYLRPAEIDADLMGWPEEWTEIGRTIAECITVLGVLGYILFQLGGEVVNIGLISFLKQLSHEPAKFIFLLSNILILACIPCRLAADRHLEDAILVVAVPGSWFLLMFFAGAVRLTGPFVTMVYSMITGDMLTFGIIYMVVLFGFSQSFHFLYKGFPRVSSSLFQSYHSTWMALFQITLGDYSYSDLSDTTYPNLSKTVFAIFMVLVPILLLNMLIAMMGNTYAHVIEQSEKEWMKQWAKIVVSLERAVSQKDAHNYLQEYSIKLGPGDDPNNPASEQRGVMVIKSKSKTRARQRKGALANWKRVGKVTINALRKRGMTGEELRCIMWGRASISTPVRASPHLNEREISGLPAASVMGGASVPPQPLVPAPTLPPGFGDALTAALDVMAFAQDIDPSGVAEGITNTGYLISDGHQSKGLPMTITESSISPTTVIEMGINKTPDAIDCPTSYSVFPPEIRNPISGVARVDQNRLNGPPPEDSAKSDPDPLLNLVIASESPESQHEALLRMAEEARISSEVKVKLDASVLESFGLGLAPAEVLAQAPVTEKDKLFEESSDDICGSNLLGTDSRLRRIKSASMRYKKETNSVDENKQNGVGVRLFDYYSSSEENPPSGVILTNGCVNESTSKVKNTTVSSASSSSDMNRENKPERVKSDVKDARWENEKLETATRDEKNHPQNVNKNHKRRAKTAKNRVSPKEVNTRGSYDSQQKETTSTPASPTDPLEPWSTRGISDMNTLLAWRENGMDSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HJY3</accession>
    <name>A0A8J2HJY3_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Exocyst complex component Sec8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HICCMSTLAB_LOCUS11640</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the SEC8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5103699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HJY3"/>
    <dbReference type="OrthoDB" id="272977at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000145">
        <property type="term" value="C:exocyst"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032584">
        <property type="term" value="C:growth cone membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007268">
        <property type="term" value="P:chemical synaptic transmission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006893">
        <property type="term" value="P:Golgi to plasma membrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006612">
        <property type="term" value="P:protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090522">
        <property type="term" value="P:vesicle tethering involved in exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039682">
        <property type="entry name" value="Sec8/EXOC4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048630">
        <property type="entry name" value="Sec8_M"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14146">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14146:SF0">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20652">
        <property type="entry name" value="Sec8_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="1" id="KW-0653">Protein transport</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Exocyst complex component Sec8 middle helical bundle" evidence="3">
        <location>
            <begin position="195"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="26"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="97"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU367079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG5103699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="897" mass="101967" checksum="930A7D0D537C21E0" modified="2022-05-25" version="1">MSGPPIKPPRGIKHTKETSGLLISVIRALSASETNEQREVEKAKLEKEYKRSDQKLDELLKEVPAKLSNYLNKKLYLHATQLLVSALSMGDGNLEGVEALREVKTELEAKKQQLQSKLLEELTRHLYVETTREVLLKRQGSGRDFQRSSEARGSRGNKVKRALLDVSYPSSQLARGLNAQQEDLTNIIEDENSLNPEENSEHFIAIIIECLALLNNIPDAVEAIKSNMQNELLNIIARTSDSIKANADKMMPKSDVSGVRIINHADGEENNGQSALLELLQTIFDQFRMIANAHSMALRSFSHVSKKYNVDVRLYEMPDVWSKIQAVLQLLLTEYLDIQNVVDRPFQPTNFSESSVDINAYFAKRKPQRQKNGSLFKFDFSLHPKTLNTYLKDQKLSNASFIDNASLKISKRLVCEPDPKNITFIFRPMMQFIEEIERALEIQPGNSCTLNSFIADYIKEEFLGRHHIMVATTIDAATKASDAWQTITPPEVMKDLGLARPLLQSTVKVEQCIAELRSLMIALPLQGEHFCTLALNILHNYRETCQSAYRNIIQSGNEDRKICSAAWLKDDDISRFIKSLPNWDNMKSETTSDKRGKITRGWSMRRQETQEEESPEDVRQRNLREAEILASNLGEGGINSSEILSDVGQLRCLALLQESVEWFALSIRLLTAELQQSKNSNDNQTLLPRVSDSLVELLEQVAVEFEELANTCILLLHLEVRVQCFHYLLPRGEYSHLCDGVQDPQEADPRVQELSRVLQNIDESLQSTLHPKKTKYIFEGLGHLITKILITSAQYIDKIDKSGIQRMCRNVFTLQQTLTNITMARELALDYARQYFELFYETPEDILNNILENGPQFSELEYINAFQLIARSQAQHSSISKQLERLSEILSEIGAAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HLL7</accession>
    <name>A0A8J2HLL7_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Similar to ITSN1: Intersectin-1 (Homo sapiens)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">HICCMSTLAB_LOCUS12305</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5106529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="207120at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035025">
        <property type="term" value="P:positive regulation of Rho protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00052">
        <property type="entry name" value="EH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11836">
        <property type="entry name" value="SH3_Intersectin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11839">
        <property type="entry name" value="SH3_Intersectin_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000072">
        <property type="entry name" value="Unconventional Myosin IB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007109">
        <property type="entry name" value="Brix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000261">
        <property type="entry name" value="EH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051480">
        <property type="entry name" value="Endocytic_GEF_Adapter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46006:SF6">
        <property type="entry name" value="INTERSECTIN-2 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46006">
        <property type="entry name" value="RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR AT 64C, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04427">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12763">
        <property type="entry name" value="EH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16652">
        <property type="entry name" value="PH_13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14604">
        <property type="entry name" value="SH3_9"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00879">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00027">
        <property type="entry name" value="EH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50833">
        <property type="entry name" value="BRIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50031">
        <property type="entry name" value="EH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="Brix" evidence="14">
        <location>
            <begin position="28"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="EH" evidence="12">
        <location>
            <begin position="608"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="13">
        <location>
            <begin position="641"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="8">
        <location>
            <begin position="1060"/>
            <end position="1121"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="8">
        <location>
            <begin position="1179"/>
            <end position="1237"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="8">
        <location>
            <begin position="1299"/>
            <end position="1363"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="8">
        <location>
            <begin position="1382"/>
            <end position="1441"/>
        </location>
    </feature>
    <feature type="domain" description="DH" evidence="11">
        <location>
            <begin position="1447"/>
            <end position="1528"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="9">
        <location>
            <begin position="1569"/>
            <end position="1685"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="10">
        <location>
            <begin position="1691"/>
            <end position="1807"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="543"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="682"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="788"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1030"/>
            <end position="1049"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="543"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="573"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="723"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1030"/>
            <end position="1039"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CAG5106529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="1832" mass="203214" checksum="3B789892D76394F5" modified="2022-05-25" version="1">MGRRKKGKCVRKNKQMDSQEPDDLIRAPHSFVIHRGIPGDHIVELTKDFRRVLEPFTASSLKERKKNSIKDFVSVSSVLHVSHMCIFSRTELGMYMKLCRIPRGPTLTFKIINFTLARDINLSTVRRCVCLNYNPADKSIDFRHYAIKVVPVGLSRGVKKLVQAKIPNLAKCQDYSEFLSKGTLSESEAEDNLKLLNQIMELLLENRQKDFCCGHNYHLQYLEKYGHCPIPTEMGKWTSTSSALLTGSLVNLGGVPQPLAAVPRPVIPGISPVAAATVPLANPAVRPVVPVQIPAASRQFRDNMGTSGVVLGTINKTSAKPPARPAPPFMGNANTITTTNVGAPPQRPAPPSSIGSGFTATTGIAPPPKPAPPSFPNSPVGASITASSMQVALPVASSMGMVQAAPIVPLNTNPAPMAAFGMGQTVAPLIQPIPGAGIVSSMPGVMPTAGVVPSMPGLIPTAGIDPSIPSVPGAIPSVTSSAVPQAPYYNTVGVMPTVPTAGMIPSVPGAVPSIPGVVPQVPGTGIPPVQPLIQANVGMNGNGSMIQTPVSTNTPLSTTARPPSIDRVGSMDSQHSQHSQHSQHSQHSQHSQNSIGSPPVDWAVPQQSRLKYTQLFNTWDRTRTGYLSGPQARNIMVQSQLHQKILAQIWTLADMDSDGRLGCEEFVLAMHLCDMAKAGETIPTSLSPDLVPPTFRRQRQSSVSSQGLPETVDPSAGMPQSSFEDKRKENFEKGQAELERRRKTLQDTQRKEQEERERKEREEADKQEKIRLEQERRRQAEIEKQMMRQREIEQEKEEQRMRAQEQREAARKEMERQRQLEWETQKSQELQAQRQKEQDIVLKLKAKNQTLTIELTSLNERVKELSQKICDTRNGVSGVKTTIDGMRSTRDSQLQEMNDLKKKLREQNQRLLALSQEKAKIEAKNKMNASHDSAGQEAMKMQFANKQITLKQLKDKIADLQQQINDKMADIENNNGQLQDVRDRMKTLINECKTLYSSFDNKRSQILELREKIESSGGIDYTSSAWAESAWGSTDQNEPVNEDEWPVDNAPVTTSAVDESGVRKYRALYEFVARNEEEISFQPGDIILVPPVQNQEPGWMAGEIRGHTGWFPESYVEPVDSEYDDTKTFVQQDSVEKRPLEEIAEVPENVSDAGSLGETTAARVEAAPAATTLTNTSTVDDNYYVALYPYSSAEPDDLNFTDGEIIEVTKSEGDWWTGTIGNRSGFFPSNYVEKCQPNINQVPVETVASTVADVVAPTSQGTPSAEKTAEQIEDERQAAEDRAELPDFSAMASQQTRGKKPEIVQVIAPYQATSTEQLDLQRGQLIMIRKKTDSGWWEGELQARGKKRQIGWFPASYVKPLTSSSNRSTPVSHGYQDSPTDPNVERVMALYPHQAQNDDELSFEKGDVIIVLSKQEESWWKGDLNGVCGIFPSNYVTPICQISAAVYLQSLTETSPEFVAVGQACQQDPRTKGMPLSSFLIKPMQRITKYPLIINKILEYTPTEHPDRQYLQEALAKAEEFCIQVNEGVREKENSDRLEWLQTHIAYNEDVLQEKLVFNSLTNSAGPRKLLHYGILHKAKSGKELVAFLTNDFLLFAQPLKTLPSGQQFSFERNENNKFKLYRKPIFLNELSMIGDSEPNGNIIPTSDASRTLGLRDSSKRPIILLAPSASECTLWARKIREARKQFAKNEKNLLQRQRSRQAQFSSCGRILVTVLQGSSLKASAGKCNAFCNVSMGSQEERTPVVPGTNCPMWDTSMQFLVKDLHEDTLCITVFDKGYYTPDDFLGRAEVRVSDIMKDCKDSCGPIQKRIKLHEVNTGEVVLKLDLRLFGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HMA5</accession>
    <name>A0A8J2HMA5_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Similar to LHX1: LIM/homeobox protein Lhx1 (Saimiri boliviensis boliviensis)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HICCMSTLAB_LOCUS10884</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5102176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HMA5"/>
    <dbReference type="OrthoDB" id="10068367at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030182">
        <property type="term" value="P:neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000075">
        <property type="entry name" value="LIM/homeobox protein Lhx1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050453">
        <property type="entry name" value="LIM_Homeobox_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24208:SF105">
        <property type="entry name" value="DLIM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24208">
        <property type="entry name" value="LIM/HOMEOBOX PROTEIN LHX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 9 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7 9 10" id="KW-0371">Homeobox</keyword>
    <keyword evidence="5" id="KW-0440">LIM domain</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 9 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Homeobox" evidence="12">
        <location>
            <begin position="97"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="9">
        <location>
            <begin position="99"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="265"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="70"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="84"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="301"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="330"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAG5102176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="341" mass="34800" checksum="B99A4FE2CB4583BA" modified="2022-05-25" version="1">MGSGSEDEDEDGSNHLHHHEGLGGSHLGPHSLGPGSTGEQSVGHVSDLPLGSDSCKQEDSEDLGSLDGDPETRDSQTENKSPDGGAGGGSGDGGAGSKRRGPRTTIKAKQLEILKTAFSATPKPTRHIREQLAKETSLPMRVIQVWFQNKRSKERRLKQLTTMGRSPFFNGSRKMRGFPLNLNHGALGGDDGPPPGFSYFPTDKFDFGYGGPVPFHHEFFGAHGPPHPHGPPFAGPGNPIPNLFVTGLDPASIGGMAAAAVTGEYPPPGAAGGPPEFLTGPPGQGPQPPSGGSPGEFLAPTGGGQGNPGGGGNCGGPGGGGGGGGGFPEQQHQMQSEGLVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HP97</accession>
    <name>A0A8J2HP97_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10">Glutamine synthetase</fullName>
            <ecNumber evidence="3 10">6.3.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HICCMSTLAB_LOCUS13399</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-glutamate + NH4(+) + ATP = L-glutamine + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16169"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.1.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8 9">Belongs to the glutamine synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.1.2" evidence="3 10"/>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5108762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HP97"/>
    <dbReference type="OrthoDB" id="1936100at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004356">
        <property type="term" value="F:glutamine synthetase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006542">
        <property type="term" value="P:glutamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.70:FF:000004">
        <property type="entry name" value="Glutamine synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.590.10:FF:000011">
        <property type="entry name" value="Glutamine synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.70">
        <property type="entry name" value="Glutamine synthetase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.590.10">
        <property type="entry name" value="Glutamine synthetase/guanido kinase, catalytic domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008147">
        <property type="entry name" value="Gln_synt_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036651">
        <property type="entry name" value="Gln_synt_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008146">
        <property type="entry name" value="Gln_synth_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027303">
        <property type="entry name" value="Gln_synth_gly_rich_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027302">
        <property type="entry name" value="Gln_synth_N_conserv_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050292">
        <property type="entry name" value="Glutamine_Synthetase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20852">
        <property type="entry name" value="GLUTAMINE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20852:SF44">
        <property type="entry name" value="GLUTAMINE SYNTHETASE 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00120">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01230">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54368">
        <property type="entry name" value="Glutamine synthetase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="Glutamine synthetase/guanido kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00180">
        <property type="entry name" value="GLNA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00181">
        <property type="entry name" value="GLNA_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51986">
        <property type="entry name" value="GS_BETA_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51987">
        <property type="entry name" value="GS_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GS beta-grasp" evidence="11">
        <location>
            <begin position="67"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="GS catalytic" evidence="12">
        <location>
            <begin position="156"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAG5108762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="406" mass="45280" checksum="14FF2AAA465B778D" modified="2022-05-25" version="1">MGLRILVKVCETNIFSRAVSGNKPLWITFGRQISCTTMSRTMLKDSPNAALNKTLLNKYLDLPQPDNKIQAKYIWIDGTGEGIRSKTRTLDFVPKHPSELPKWTYDGSSTYQAEGGNSDVFLLPVAIYRDPIRRGNNKLVLCETYTSDMTPTATNKRFRCNQAMEAVKSEEPWFGIEQEYTFLDFDNRPLGWPKNGFPGPQGPYYCGVGADRVIGREIVEAHYRACMYAGVNIAGTNAEVMPSQWEFQVGPSVGIAGGDDLWIARFLLHRIAEEFGVIVTLDPKPVDGSWNGAGAHTNFSTKSMRKENGIVEIEKAIEKLSKQHVKHIQAYDPRGGKDNERRLTGKCETSSIHDFSAGVANRGASIRIPRGVAEDKKGYLEDRRPSSNCDPYSVCDALVRTCLLNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HPQ0</accession>
    <name>A0A8J2HPQ0_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to SMOX: Spermine oxidase (Homo sapiens)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS13182</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5108328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HPQ0"/>
    <dbReference type="OrthoDB" id="5046242at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046592">
        <property type="term" value="F:polyamine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.660.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050281">
        <property type="entry name" value="Flavin_monoamine_oxidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10742:SF398">
        <property type="entry name" value="AMINE OXIDASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10742">
        <property type="entry name" value="FLAVIN MONOAMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00419">
        <property type="entry name" value="ADXRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035207293" evidence="1">
        <location>
            <begin position="36"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="domain" description="Amine oxidase" evidence="2">
        <location>
            <begin position="51"/>
            <end position="508"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5108328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="513" mass="58363" checksum="DC93665787EFD432" modified="2022-05-25" version="1">MIKQARLSLSHSYKNPHSVKMKLLILICLINFALSSEEMFPRILIIGSGPSGIATASKLLQNGFRNLTILEAENRIGGRVYSIKLGDYLVDVGAQWVHGEKDNVAFELAWPLGLLERLSDNKEFDFNSKIYGSNGEEISLNASSSLVGYLMENISSSDSINESLKDLKSVSFGEYAEKKLMEFFKNNEEIPANKHKPLLHLLDMVEMTNEAAPSWHNLSAKNVRDYPECEGDQAINWKERTYATILDILMKKYPNPEEELPVKNITKLNTKVTEIKYDETPLKVITADKEEYLADHVIVTVSLGVLQKNIDTLFKPQLPEKKLNTIKSLSFGTAAKILIYYDVPWYVNEPIGLWAMYWTEEDQKQIENDPQKRWMLGLSVGSKTEHKPKLFVLWVTGPHVNEMETLSEEMFQEQVKDILKRFFGKACNLTEPSIIKRSSWSTNENFLGTWSYVSVQAEVNGIDNKDYAEPIMKNESPVLQFAGEATAYHSATVHGAIESGWREADRLIKFYNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HQT9</accession>
    <name>A0A8J2HQT9_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Similar to ARL16: ADP-ribosylation factor-like protein 16 (Homo sapiens)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HICCMSTLAB_LOCUS12512</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5106942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HQT9"/>
    <dbReference type="OrthoDB" id="365445at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46688">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46688:SF1">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="6"/>
            <end position="13"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="13"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAG5106942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="192" mass="21166" checksum="4B53A7ACED4D2085" modified="2022-05-25" version="1">MCLCLGPAKSGKTLLMKRLQGDEKIDDASHTVPTNGVNLFTIKSDDGHFDIIVREIGGSMAPIWHHYFDRVHKIIYVVDASNLCQISAAGVLLYSLLVEPKLQHVKICFVLGKMDLSYRQMRNEALLMLHFNRLIREVSQKITVIEASGMTGQGIELLRNWIFDPETLKAVGATGNAAAAAAAANVIFTTKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HRM3</accession>
    <name>A0A8J2HRM3_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Similar to cpeb1-b: Cytoplasmic polyadenylation element-binding protein 1-B (Xenopus laevis)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HICCMSTLAB_LOCUS13686</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5109050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HRM3"/>
    <dbReference type="OrthoDB" id="10033548at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003730">
        <property type="term" value="F:mRNA 3'-UTR binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000900">
        <property type="term" value="F:mRNA regulatory element binding translation repressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008135">
        <property type="term" value="F:translation factor activity, RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000766">
        <property type="term" value="P:negative regulation of cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19757">
        <property type="entry name" value="Bbox1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.640.40:FF:000002">
        <property type="entry name" value="Putative Cytoplasmic polyadenylation element-binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.640.40">
        <property type="entry name" value="Cytoplasmic polyadenylation element-binding protein, ZZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032292">
        <property type="entry name" value="CEBP1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032296">
        <property type="entry name" value="CEBP_ZZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038446">
        <property type="entry name" value="CEBP_ZZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034819">
        <property type="entry name" value="CPEB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12566">
        <property type="entry name" value="CYTOPLASMIC POLYADENYLATION ELEMENT BINDING PROTEIN CPEB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12566:SF9">
        <property type="entry name" value="CYTOPLASMIC POLYADENYLATION ELEMENT-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16368">
        <property type="entry name" value="CEBP1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16366">
        <property type="entry name" value="CEBP_ZZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16367">
        <property type="entry name" value="RRM_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2" id="KW-0810">Translation regulation</keyword>
    <feature type="domain" description="RRM" evidence="6">
        <location>
            <begin position="485"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="33"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="115"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="196"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="240"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="338"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="219"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="242"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="267"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="290"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="343"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAG5109050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="724" mass="81100" checksum="5B8DA3EA0B084AA3" modified="2022-05-25" version="1">MFENDLWESDNTENSFDFHFSTLAMSFEAENNNATDGLRGSESSCEPPQNHQLQHDQYDREYLQPQQLQRDYEGLQLPQVDFQRQHDVQIREYEREQSSIYQIRAPQRESLFQRRERERDSFQLHHQPERSESRIDQYRDKLHQPLKTLGSLLLDVPTPTVPFHPHKDTSYDQTDSNLEEDMSISDLFGLGLPRGSLMGSQSSINSPGYRRHQQQQTQNHGQSNVSRPYNKYQNFEEDRGYFTSSPSIDMPGTPNSVATPGSPGTPSSLYSSAYSYSTSGTGSSQLTSSPASARSGYQSYVGSPTSSINSPPYYGRPIRGSSPYSDCSSPSMEYPPVISCNGSRSTSPSDSDLSGINSMEGSLSDIMACLSLNSPVTHTCHSHGSVNSDFADICPNNRAAALQCMAMKKYLASTHHDQSFRHHHCCNSNGNHMAPVSSSVGLNEPYISLDRAARIHRSAASLHKATHTWSGTLPVRTLKPTGFSSKVFLGGLPWDVTESTLIATFKHIGPIKVEWPKKDHPNAPDPKGFGYIIFESEKEVRTLLSCCVPCFNNKNRLLYKVSSKRIKGKDVQVIPWALNDSNYSKSSSQKLDPGKTVFVGIDTDKHKYPIGSARLTFSSKRSYRKAVAAAFIEIKTAKFSKVVQIDPYLEDSVCSVCYVQQGPYFCREQVCFRYFCRNCWLWQHSMDPMRLHKPLTRISKTNQVVGLTPGLGMLPASRTSGSVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HRR6</accession>
    <name>A0A8J2HRR6_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Olfactory receptor 71</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HICCMSTLAB_LOCUS13229</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5108422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HRR6"/>
    <dbReference type="OrthoDB" id="7677057at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005549">
        <property type="term" value="F:odorant binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004984">
        <property type="term" value="F:olfactory receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004117">
        <property type="entry name" value="7tm6_olfct_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21137">
        <property type="entry name" value="ODORANT RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21137:SF42">
        <property type="entry name" value="ODORANT RECEPTOR 83A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02949">
        <property type="entry name" value="7tm_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0552">Olfaction</keyword>
    <keyword evidence="7 11" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035188187" evidence="10">
        <location>
            <begin position="20"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="97"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="168"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="242"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="283"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="357"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAG5108422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="393" mass="45417" checksum="E27D138601603EBD" modified="2022-05-25" version="1" fragment="single">VCFNVSLITLSFFLILSIAVDIKNSHDLSSFAKLDPLCFHLIGFSKWITGLFHLNEIKDLVLRMKRCHKLCLNYNENYQHYNTKIIKFNNYMKKFTYLWLLICVGGMIQWCFNPIIQDFLLELFEEKKINSTSSRTLPFPGAFPWIINSTLKYILTFTFQFFSSLSTAFELAVFDVLNVILLANVCFNFQHLNEILAKNHADIMIVRFSSSDKSTLKFKTKLRNCIVHHQEVLIFIAKLKDVFSYPMFIVCLDSTIALCLVSFEASTIKINSSVESITKLINMVQYWIGIVTELFIYCFLATKIEDLGLKTADAIYVCNWEQSMVNYRDNFVGEHRDEILEINQMVKFSIMRAQKPIIINGGLFYVLSLQTFKALVGLSLSNAIVLRQLAEET</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HSK2</accession>
    <name>A0A8J2HSK2_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Similar to INO80D: INO80 complex subunit D (Homo sapiens)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HICCMSTLAB_LOCUS12528</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5106986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HSK2"/>
    <dbReference type="OrthoDB" id="10038011at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025927">
        <property type="entry name" value="Znf_KANL2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16198">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16198:SF2">
        <property type="entry name" value="INO80 COMPLEX SUBUNIT D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13891">
        <property type="entry name" value="zf-C3HC3H_KANSL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="KANL2-like probable zinc-finger" evidence="5">
        <location>
            <begin position="245"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="41"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="307"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="491"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="58"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="307"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="328"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="345"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAG5106986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="571" mass="64433" checksum="71C5FAD305CD5C9D" modified="2022-05-25" version="1">MKIPAEEAFEMDNKLKFSDRLKALLKTDPRQDIDPYIFSEPEPFHGAGKHNNAESIKNSRMSGGKSNGSKGKCSRKRIKAEHNASSSENVASVMDNARLVGDNSSLRSVELRIGHGSRVKEDPSREPVRRLSRDHTLLYYPRAGDEIPDSDSSSDELGVYQRHWFSGDTSNVPRATRLTLLRSQLRRRLIQLHKDGKESETLLYKRTRRLLDAACRSSRQLKGHLTSSSIHKKDNTDHLLVGSRCLAEGCQYMSLPSTRHCSRHIMLNGDQLLFEHCTAKFSDNTQCCVPVFDVAHELPLCPEHARKRDNYNRKAQESKPKKSRKKPTSPTSIPRPKNTSSSSKSRPKKRKRPPSVKPIDIKPNVNIRHCQQQEETIHLDNHHSSQIITPTIIPVNNICNNNKTLNNVAQSMPTNPITNNLNLGSLGLGSLGLGPGLNTGLRVELDQEVFAALDPNEHDFNNVLNTLPVDLNELFLESRNGEYEQPSKEEAEELERALEEVDKDVRSLEQMEQTRSLLERNLERMEQTHGLLGRNLEHLESNHGLLERNLEPTHGLLEPALLAQLMSDIAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HTG6</accession>
    <name>A0A8J2HTG6_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ER membrane protein complex subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HICCMSTLAB_LOCUS13120</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of the ER membrane protein complex (EMC).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Endoplasmic reticulum membrane</location>
            <topology evidence="5">Peripheral membrane protein</topology>
            <orientation evidence="5">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the EMC2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5108203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HTG6"/>
    <dbReference type="OrthoDB" id="124397at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072546">
        <property type="term" value="C:EMC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039856">
        <property type="entry name" value="EMC2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055217">
        <property type="entry name" value="TPR_EMC2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12760">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22890">
        <property type="entry name" value="TPR_EMC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 4" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="EMC2 TPR-like" evidence="6">
        <location>
            <begin position="49"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="4">
        <location>
            <begin position="111"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU367091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF22890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAG5108203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="248" mass="28693" checksum="5293AD95F209892A" modified="2022-05-25" version="1">MDKLGNEKYLILEQVCVAALDCHRLPLAEYTSKILMKEFPGSLRVHKYHAMHLEALELYDEALEVLESIIKRDETNAAPRKRKVAIFKARGKTAEAIKELTEYLKVFMSDQEAWYELCDLYLKEQEYAKAAFCMEELILHNPHNHLIYQRYAEIKYSQGGFENIETAKVYFSQAAKLNPNNMRALYGLLLSANYIATSSKCPLSKKKEAIKLSEWTASQIEKQYKTKVFDNSNIENLESLIEKLHLDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HTZ0</accession>
    <name>A0A8J2HTZ0_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Similar to GPR155: Integral membrane protein GPR155 (Homo sapiens)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HICCMSTLAB_LOCUS13514</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5108878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HTZ0"/>
    <dbReference type="OrthoDB" id="2133778at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030514">
        <property type="term" value="P:negative regulation of BMP signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04443">
        <property type="entry name" value="DEP_GPR155"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000591">
        <property type="entry name" value="DEP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037368">
        <property type="entry name" value="GPR155_DEP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004776">
        <property type="entry name" value="Mem_transp_PIN-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051832">
        <property type="entry name" value="mTOR-Rac_regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22829">
        <property type="entry name" value="DEP DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22829:SF5">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN GPR155"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00610">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03547">
        <property type="entry name" value="Mem_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00049">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50186">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="43"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="73"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="104"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="136"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="182"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="208"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="243"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="282"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="314"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="356"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="387"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="417"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="459"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="501"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="616"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="650"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="domain" description="DEP" evidence="6">
        <location>
            <begin position="729"/>
            <end position="794"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAG5108878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="794" mass="88314" checksum="604AD5D9698128D1" modified="2022-05-25" version="1">MELDIPDTPTDNLYLALIQCFAIILCGYIAGRLEIITKSEANGLNTFVGTFALPSLIFLSLAKLDFSLVNWKFLLAVFLAKACVFLVVLGVSLIVTRPTNPGRAALFAIFATQSNDFAIGYPMIDALYGDTHSEYAAYLYLMAPISLAILNPIGFILLEIGKRRTGSQQSGWKLVGSVVKGIGLNPILFMTVLGIIGNFIFSHQIPKILSVILEVFGNAFSASALFLLGLMMVGKIHTLKGPALVIPGILISVKLLALPMIIRESVILLNAGVNETDTRDLSTYGFLYGTIPTAPALFIFTLRYNIDIDLIASSMVACTFLSAPLMFVSAKLITAINDGVSPAKYAQQLNTFSMDVSVASIAACLWLFVCFVVLAGKRYKRPTHRCTLYLIIAQLAVGIGVIIWTKLEPNEIGSFLWYVQFVLITVGVYASRMWTVVLAGTLLFLSSRTLTFVQNMQKWIMPIGFMVPVLTVGLMCLIISPKNPDDIDLRNPNFQFGRVQAAISIFILLFCFIVTLGCLVLQQRYQRRHHAEVYASLINNNTDNAESTMVETRNIVDVEDLIPSGPALPAGNCVLDTGCGFQRNGGCIQDDLVDEQDFEIDQLRIDSDDPQLLRHLVLLIFLLCSMFIGLALSIGTMIMEQMTGVYAELAFLDVAFSYGQSLIVFVIFGLDPGLGKLGSWLKKVCKEWRTRQKLQLPDEESLSAETKTIREQFRQCHLHECRQRISNCRRRLLKVYQGVFSGSDLVDWLLEQRLVQNREEAVQYGRCLLESRVLHHVDGTHHFHDKNILYSFRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MEC5</accession>
    <name>A0A8J2MEC5_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">TATA-box-binding protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">TATA sequence-binding protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">TATA-binding factor</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">TATA-box factor</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Transcription initiation factor TFIID TBP subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HICCMSTLAB_LOCUS4310</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="9">General transcription factor that functions at the core of the DNA-binding multiprotein factor TFIID. Binding of TFIID to the TATA box is the initial transcriptional step of the pre-initiation complex (PIC), playing a role in the activation of eukaryotic genes transcribed by RNA polymerase II.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TBP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5085221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MEC5"/>
    <dbReference type="OrthoDB" id="2127950at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000992">
        <property type="term" value="F:RNA polymerase III cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001092">
        <property type="term" value="F:TFIIA-class transcription factor complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042797">
        <property type="term" value="P:tRNA transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd04516">
        <property type="entry name" value="TBP_eukaryotes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.310.10:FF:000001">
        <property type="entry name" value="TATA-box-binding protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.310.10:FF:000002">
        <property type="entry name" value="TATA-box-binding protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.10">
        <property type="entry name" value="TATA-Binding Protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00408">
        <property type="entry name" value="TATA_bind_prot_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000814">
        <property type="entry name" value="TBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030491">
        <property type="entry name" value="TBP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012295">
        <property type="entry name" value="TBP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033710">
        <property type="entry name" value="TBP_eukaryotic"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10126">
        <property type="entry name" value="TATA-BOX BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00352">
        <property type="entry name" value="TBP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00686">
        <property type="entry name" value="TIFACTORIID"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55945">
        <property type="entry name" value="TATA-box binding protein-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00351">
        <property type="entry name" value="TFIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="27"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00030739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00033017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00037612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00042653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00042691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAG5085221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="323" mass="35360" checksum="F09E857E1A87B313" modified="2022-05-25" version="1">MDQMLPSPGFSIPSIGTPLHQLEEDQQILPNALQQQQQQPSSSQQSQYPLQQLHSMSPNLGSGMFPMSTPQKTMHTYAPTPAFATPQSMMTPQTPQHMMSPAVQPANHLAPTGSPAPGIGSTGPMTPGSVMTPGSAVNPASADPGILPQLQNIVSTVSLNCKLDLKKIALHARNAEYNPKRFAAVIMRIREPRTTALIFSSGKMVCTGAKSEEDSRLAARKYARIIQKLGFPAKFLDFKIQNMVGSCDVKFPIRLEGLVLTHGQFSSYEPELFPGLIYRMVKPRIVLLIFVSGKVVLTGAKVRTEIYEAFDNIYPILKSFKKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MFS5</accession>
    <name>A0A8J2MFS5_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similar to Ccdc142: Coiled-coil domain-containing protein 142 (Mus musculus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS2546</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001117">
        <property type="protein sequence ID" value="CAG5077743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MFS5"/>
    <dbReference type="OrthoDB" id="6579237at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026700">
        <property type="entry name" value="CCDC142"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055350">
        <property type="entry name" value="CCDC142_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21436">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 142"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21436:SF2">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 142"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14923">
        <property type="entry name" value="CCDC142"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Coiled-coil protein 142 C-terminal" evidence="1">
        <location>
            <begin position="216"/>
            <end position="574"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5077743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="618" mass="70566" checksum="AED6B9A243E339EE" modified="2022-05-25" version="1">MKRLLNTVAKFIHYFVNQTLDLESDVLALKFLRLIKIYIDALNLDYKITDSSINIFSNDCPSMLESLKPLSILRVLQILARNKAEEYCYELIDCLLAIYQPNNQEKCNSSASGDMEMSENSSVEIYRALTKHITPPGSAIINSSARRKYSNAHIENFQILVDSQKVQIKKIIHTAKDIAPLLFQADSFRYDNQGEIVKVRSSILARLSDYYCQVSWAAISEILDHVILWWSPEGLATRHNHGAQYLKDWLHSFLLTPSNVPISIRPTLDNLCETLGCHVTATCWDELFRLAYIASFECASRPCSSEGTDTGQMFAQVFQLLVNLSNECEVSGEWAIGAPLMELPLSEQIIILHRLDHSIHTMRLWASHESKLIAHTWDLESFFLLVKGDLHQCIDQLSYLKLADHTAALATDDVSVQVYVCTRMRAKIVSEVNANYLLLKESSSKCISTLAKICRVISLANLHMCFPISNIWRRTSIVSNINPSPYVQVYLERVLLPVLEVVEDEDISNMVLKIMCEAWLDYIYLHRVKFSEIGAYQLLSDFAFVTQWVSNCSIISQNVKDQLLKNEVLRRCEATRSSDGSPESLGLERMPAEMYVPNQEQWLELRAEKNYKLYCCTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MGM3</accession>
    <name>A0A8J2MGM3_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Mitochondrial (Rattus norvegicus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HICCMSTLAB_LOCUS2821</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001117">
        <property type="protein sequence ID" value="CAG5078723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MGM3"/>
    <dbReference type="OrthoDB" id="5550281at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00084">
        <property type="entry name" value="HMG-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050342">
        <property type="entry name" value="HMGB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48112">
        <property type="entry name" value="HIGH MOBILITY GROUP PROTEIN DSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48112:SF22">
        <property type="entry name" value="MITOCHONDRIAL TRANSCRIPTION FACTOR A, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HMG box" evidence="4">
        <location>
            <begin position="45"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="HMG box" evidence="4">
        <location>
            <begin position="150"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="2">
        <location>
            <begin position="45"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="2">
        <location>
            <begin position="150"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="109"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAG5078723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="246" mass="29487" checksum="998989E0F2A99E93" modified="2022-05-25" version="1">MACNKLLNFCNTKIISLPRNCLVLSRDYSAKRRLMEQRLDLPERPKRPQNAFLRYTALVRDELKEKFPEAKVPDLCRLYGKKWAQCDPALKKELQDQYREDMLKYSHQMMDYERKLTDEQKMVIEEENRRVEANKKKNVLRARLLELGKPKKPPTAFILYMMSHVKSKDPDTAVQDWMGEISKEWAKLPSEKREKFETEAKKLMEQYKNDMIDWEAKMIQMGHFDVIRRQVLLDLKDKTGQEEKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MH81</accession>
    <name>A0A8J2MH81_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Platelet-derived growth factor receptor-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HICCMSTLAB_LOCUS6032</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subunit">
        <text evidence="1">Forms a complex composed of PDGFRL, TNK2 and GRB2.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5092306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MH81"/>
    <dbReference type="OrthoDB" id="7613723at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042495">
        <property type="entry name" value="PDGFRL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15360">
        <property type="entry name" value="PLATELET-DERIVED GROWTH FACTOR RECEPTOR LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15360:SF4">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000615">
        <property type="entry name" value="TyrPK_CSF1-R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0675">Receptor</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035324386" description="Platelet-derived growth factor receptor-like protein" evidence="3">
        <location>
            <begin position="17"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="4">
        <location>
            <begin position="234"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00019671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAG5092306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="574" mass="66653" checksum="9F9BC5D2CE3F7566" modified="2022-05-25" version="1">MVKMLMLLMYIRQIKGSLDLRTGASSNFTLLSIVEGESLIIDCKNTEKITFLYPKFPKNEVITSPEEITVSLSDKVYSAKFERKKAVYNDSGWYGCADLPDEFDKLYQNRFPFTPDLYNSSNVRWVYVFVKSLDHLFVNTPFVLNDTEGHYRLIEKVGNDVILPCRPTSPNYRVGLQFGNRTDVPFNYSLYDPTIGFVIKNIISNHSLSYICESFNSNGDFEVKHFQITLKRYPEFRDVPVISTDSLTHMEVGKDFIMKCEICIYQPNQYSFGWQMPRPNNRTSQKLIRLNVSKRPSVDFWDSDICETQIIELQIKSVTIEDFGVYRCDLYRYPVLNSATVNLVPHEKKHLELSMRVRNDSKPVRKSHSYTWDLEVDAYPLPVEFKWLGPGGYEISNFWSYENYQVNDERFSVKLTKWDVDWKDTGTHVIFAHNSEEIKIFSFNVLVEGIPEIIDFVENDVDCYLRHETVFFDCAARGYPQPVITWKFGKDYKSSNDIPLSSVYSKNGTSSDNIPKVFSTAWVEILGSGMMFCEACNKYGCDWKVMQSVYITLSPKCCNTKKKQRWKLNFSSLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MI18</accession>
    <name>A0A8J2MI18_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Similar to Csde1: Cold shock domain-containing protein E1 (Mus musculus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HICCMSTLAB_LOCUS4219</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the UNR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5084872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MI18"/>
    <dbReference type="OrthoDB" id="74319at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04458">
        <property type="entry name" value="CSP_CDS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011129">
        <property type="entry name" value="CSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019844">
        <property type="entry name" value="CSD_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056400">
        <property type="entry name" value="CSDE1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002059">
        <property type="entry name" value="CSP_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024642">
        <property type="entry name" value="SUZ-C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12913:SF1">
        <property type="entry name" value="COLD SHOCK DOMAIN-CONTAINING PROTEIN E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12913">
        <property type="entry name" value="UNR PROTEIN N-RAS UPSTREAM GENE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00313">
        <property type="entry name" value="CSD"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23456">
        <property type="entry name" value="CSDE1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12901">
        <property type="entry name" value="SUZ-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00357">
        <property type="entry name" value="CSP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00352">
        <property type="entry name" value="CSD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51857">
        <property type="entry name" value="CSD_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51938">
        <property type="entry name" value="SUZ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="CSD" evidence="6">
        <location>
            <begin position="66"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="CSD" evidence="6">
        <location>
            <begin position="234"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="CSD" evidence="6">
        <location>
            <begin position="389"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="domain" description="SUZ-C" evidence="7">
        <location>
            <begin position="464"/>
            <end position="504"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00044751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG5084872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="514" mass="57276" checksum="94426611F3CF42F9" modified="2022-05-25" version="1">MEIACNQFKLYSNLILMTFFQAYKFFVHRHGDWVQFLIATDTRDQLKRATEISLLPESFTVSGERREQGIIAALKDGFGFIRCVDRDARLFFHFNEVLDIDREIAVGDEVEFTVIQDPPTFFSNTRQSAIRLKHLPSGTVQFETVTESDLVGTVIQDISGMDPGLIGYTKNGQQNNIIFFTKDCDSKVIPKLGDKVKFSICQVKRNKELVAVDISLLDVKEEKAENANNVNGLECQGFIAALKDGFGFIETFNHEREIFFHFSTFDGDASTLEVGAEVECTIGSGNSRSTGGCTAAESVHIVPRGTIPRAAIVSEVLDGTVIRPLRSANPEQSEYAGMIKLSVITDENNAKKYEFGIMGLLNKRELLQTGDPVQFQVDSEGHACNIVAVRKKRIATVDAVKGAFGFLTYEIDDGKKLFFHMTEVKDHTTLQPGDQVEFVLVTNQRTGKSFACNITRLSGESVQQRPERLISRLRTISLEDAGPKLTVVRQPKGPDGTRGFSYDRSQHISGIIEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MI25</accession>
    <name>A0A8J2MI25_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Endonuclease/exonuclease/phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS4234</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5084934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MI25"/>
    <dbReference type="OrthoDB" id="7701337at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14529">
        <property type="entry name" value="Exo_endo_phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="1">
        <location>
            <begin position="84"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5084934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="227" mass="25559" checksum="9EDAC3C0599B48AD" modified="2022-05-25" version="1" fragment="single">MKITFWNIHGLPNLSQCPAILKHDVIAACETWSTYQQNPIYLNNFQSYWANATREHLVGRPSGGLVTAICKEYCSEVLEDPLDHFKTLHNYDIIILGGDMNAKVGQADLWLEEIFNGLALNKVMSTTDHATCDRGIKLLEFMGDNNFVLINGRTDNDTPAQPTFDERGSSIIDLIWVNVTCLHYILDLEVLIEPTLSVHRPVCLSINIEVSSQDDTMTITIPRPITK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MJ78</accession>
    <name>A0A8J2MJ78_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Similar to WDFY2: WD repeat and FYVE domain-containing protein 2 (Homo sapiens)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HICCMSTLAB_LOCUS7516</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5095052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MJ78"/>
    <dbReference type="OrthoDB" id="63070at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15718">
        <property type="entry name" value="FYVE_WDFY1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000105">
        <property type="entry name" value="WD repeat and FYVE domain-containing protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042234">
        <property type="entry name" value="WDFY1/WDFY2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000306">
        <property type="entry name" value="Znf_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46189">
        <property type="entry name" value="LD41958P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46189:SF1">
        <property type="entry name" value="LD41958P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01363">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00064">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 7" id="KW-0853">WD repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="166"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="209"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="domain" description="FYVE-type" evidence="8">
        <location>
            <begin position="252"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="333"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAG5095052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="371" mass="41809" checksum="F8434E1A56B9D5DC" modified="2022-05-25" version="1">MAAEIKPAPGVSNDKFSSSRKPILLSKLEGCNDDINVAIIIPKEEGVISVCDDRTVRVWLKRDSGQYWPSVCQYMASGATAMDYHVETRRLFVGLENGSIDEFLLEQDYNRMTAMREYVAHRARITAIVFSAVHGWVMSVSRDKTFQLHCSETGKRLGSYGYGTLFAAHTGSIRSLAWDPEKQLLFSGSFDQTIRVMDIGGGEGVGYELRGHRNKVTALCYARNERVLFSGGEDGVIVCWNMAESRRETTPWKESDTCESCGRPFFWNMRAMMDQRQLGLRQHHCRNCGRALCASCSAQRIPIPPMGFEFEVRVCDPCHTQLKAANQSAMASFHDAKHSIMSMNLDISRRKLLTVGQDRIIKIWDITALLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MKB3</accession>
    <name>A0A8J2MKB3_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Prohibitin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HICCMSTLAB_LOCUS5927</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the prohibitin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5092122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MKB3"/>
    <dbReference type="OrthoDB" id="275637at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03401">
        <property type="entry name" value="SPFH_prohibitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.479.30:FF:000001">
        <property type="entry name" value="Prohibitin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.30">
        <property type="entry name" value="Band 7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001107">
        <property type="entry name" value="Band_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036013">
        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000163">
        <property type="entry name" value="Prohibitin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23222">
        <property type="entry name" value="PROHIBITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23222:SF1">
        <property type="entry name" value="PROHIBITIN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01145">
        <property type="entry name" value="Band_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00679">
        <property type="entry name" value="PROHIBITIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00244">
        <property type="entry name" value="PHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117892">
        <property type="entry name" value="Band 7/SPFH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Band 7" evidence="7">
        <location>
            <begin position="41"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU366048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG5092122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="247" mass="27270" checksum="5C6580B6AD7A15D3" modified="2022-05-25" version="1">MAQSTLNDLAGKFGGSPPKGVGVGLKVLAVAGAAAYGISQSMFTVEGGHRAIIFSRLGGIQKDIFAEGLHFRIPWFQYPIIYDIRSRPRKISSPTGSKDLQMVNISLRVLSRPDAMALPVMYRQLGLDYDEKVLPSICNEVLKSVVAKFNASQLITMRQQVSMLVRRELTERAKDWNIVLDDVSITELSFGKEYTAAVEAKQVAQQEAQRAAFVVERAVQERQQKIVQAEGEAEAAKMISFFSSLDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2ML97</accession>
    <name>A0A8J2ML97_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">ethanolamine-phosphate cytidylyltransferase</fullName>
            <ecNumber evidence="10">2.7.7.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">CTP:phosphoethanolamine cytidylyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">HICCMSTLAB_LOCUS6896</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="9">Phospholipid metabolism; phosphatidylethanolamine biosynthesis; phosphatidylethanolamine from ethanolamine: step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytidylyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.14" evidence="10"/>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5093527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2ML97"/>
    <dbReference type="OrthoDB" id="40021at2759"/>
    <dbReference type="UniPathway" id="UPA00558">
        <property type="reaction ID" value="UER00742"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004306">
        <property type="term" value="F:ethanolamine-phosphate cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006646">
        <property type="term" value="P:phosphatidylethanolamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd02173">
        <property type="entry name" value="ECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004821">
        <property type="entry name" value="Cyt_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044608">
        <property type="entry name" value="Ect1/PCYT2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00125">
        <property type="entry name" value="cyt_tran_rel"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45780">
        <property type="entry name" value="ETHANOLAMINE-PHOSPHATE CYTIDYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45780:SF2">
        <property type="entry name" value="ETHANOLAMINE-PHOSPHATE CYTIDYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01467">
        <property type="entry name" value="CTP_transf_like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5 14" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="7" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="8" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Cytidyltransferase-like" evidence="13">
        <location>
            <begin position="11"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="domain" description="Cytidyltransferase-like" evidence="13">
        <location>
            <begin position="144"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="90"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="90"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CAG5093527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="308" mass="35099" checksum="D9510841FF3DA7A9" modified="2022-05-25" version="1">MSEKRKEVRVWCDGCYDMVHFGHANSLRQAKALGDYLVVGVHTDEEITKHKGPPVFTQEEREVQRTAGVSTTDLVGRMLLMTRQHFKQGDSEYSVDREPSESMGQDRSARSPWTGCSQFLPTTQKIIQFSDGKSPQPGDKIVYVAGAFDLFHVGHLDFLEVAKREGDYLIVGLHTDPAVNRYKCGNHPIMNLHERVLSVLACKYVNEVVIGAPYEVTKDLMEHFNVSIVCHGQTPIMPCEGGTDPYIEPKRQNKFKLLNSKNDMTTEKIIERIILHRLEFEDRNLKKEKKEIAAYEAFVKSQNKEISE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MLM6</accession>
    <name>A0A8J2MLM6_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DET1- and DDB1-associated protein 1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HICCMSTLAB_LOCUS6514</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5093002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MLM6"/>
    <dbReference type="OrthoDB" id="8598182at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018276">
        <property type="entry name" value="DDA1_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10172">
        <property type="entry name" value="DDA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="domain" description="DET1- and DDB1-associated protein 1" evidence="3">
        <location>
            <begin position="149"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="173"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG5093002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="216" mass="23686" checksum="7254D92C1FB445B3" modified="2022-05-25" version="1">MSANDILGFSLRTLSRLSFKNLKYPVSGCLGAVASLGVFLRFFDLFLFTGVTLLVLAFKDFLSPAESALSSADSLYGDLFPENSSPSPFTFDGCWLAVIIVIEDTDSSPFTALLSFSPVNIFLPFATLCSVNQAYNSETHAHALNSVSEFLKGLPSHDENNFANFHTDNGNRTCVKRPSNAERKRDVLSPNGGSDQSEDVTVRRCKRPRLDLNNTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MMV9</accession>
    <name>A0A8J2MMV9_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS7850</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5095722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MMV9"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5095722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="99" mass="11401" checksum="AE9BEC80DA24C926" modified="2022-05-25" version="1" fragment="single">NNNNIIIIDSTNPQKHHTSHRFFEAFSDIDPFGRDRTTRSFTKAHDCDVNDYSHPGHVRSPFICPLATIILCDKLPTQVSIFQMTELTIENKKSDRNND</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MNM4</accession>
    <name>A0A8J2MNM4_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS7301</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5093975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MNM4"/>
    <dbReference type="OrthoDB" id="10464480at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="126"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5093975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="248" mass="28622" checksum="F01275888F6B54A9" modified="2022-05-25" version="1" fragment="single">DKSLENINNECKQIIKSISLIKYDIRRDDKTPIYWTAFVQKIIEDFKESLVVNIRNSLKSARNFFEGDNIISGAFLVIDAHYLDGQIVFQPDVEEIKRVIELITSLDKEVYSIEICNKIFDLIDLRAKDKITLIEAQEEITELKNNLKEETDAAIAALDKFIKSLDIKLLAQVEGKLSEFKNEDNYNKNSFEEEILRCSELSKAISLIADNVDIKFISLNTVNMKLQIIEKCDNLKCLQCLKYTKLKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MP50</accession>
    <name>A0A8J2MP50_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to BOLA3: BolA-like protein 3 (Bos taurus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS9136</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the BolA/IbaG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5099592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MP50"/>
    <dbReference type="OrthoDB" id="203381at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.90">
        <property type="entry name" value="BolA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002634">
        <property type="entry name" value="BolA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036065">
        <property type="entry name" value="BolA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052275">
        <property type="entry name" value="Mt_Fe-S_assembly_factor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46188">
        <property type="entry name" value="BOLA-LIKE PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46188:SF1">
        <property type="entry name" value="BOLA-LIKE PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01722">
        <property type="entry name" value="BolA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82657">
        <property type="entry name" value="BolA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5099592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="131" mass="14405" checksum="AD235B4D89CD644D" modified="2022-05-25" version="1">MYLLKQINTAITRQANASRHISILTGMNRVNKSTTLQLLSKVWSGQSGVLAGKQAEEKMTSILRNKFPKAQTIEVNDISGGCGAMFEVNVITCEFDGLSTVKQHRLINDTLKNEIKDMHGIRISTGLPDSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MQU2</accession>
    <name>A0A8J2MQU2_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Similar to Top3a: DNA topoisomerase 3-alpha (Mus musculus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HICCMSTLAB_LOCUS10980</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5102368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MQU2"/>
    <dbReference type="OrthoDB" id="430051at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010666">
        <property type="entry name" value="Znf_GRF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33680:SF1">
        <property type="entry name" value="OS05G0489500 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33680">
        <property type="entry name" value="OS07G0190500 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06839">
        <property type="entry name" value="Zn_ribbon_GRF"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51999">
        <property type="entry name" value="ZF_GRF"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="GRF-type" evidence="6">
        <location>
            <begin position="18"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="domain" description="GRF-type" evidence="6">
        <location>
            <begin position="88"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="GRF-type" evidence="6">
        <location>
            <begin position="187"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="135"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="138"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="148"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAG5102368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="269" mass="30671" checksum="A80553DE4838FC6B" modified="2022-05-25" version="1">MSYLKNRRITMSSFNYKCKCNEPAKKTIVRKEGPNKGRVFHACAKKPGSNCKFFRWADKKSASKSEHDNLEENLQENKINVNEGNLICVCGELARKFVVKKEGANKGRSFYGCSRGQESACEFFQWANIDVAARKQPSAVQQPSENNLEWEWDEDEDWDRDRGDDQNRLYDQYTSGTLNSVENQVRCICGQPARLQTVEKDGANKGREFYTCSKESPKSCGFFDWAQDYSTRSAGSIPAKKKPAQPKKKLGDKKYDVMTLNILRIPSKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MR13</accession>
    <name>A0A8J2MR13_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS8253</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5096525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MR13"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5096525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="59" mass="6730" checksum="9037F442646148E4" modified="2022-05-25" version="1">MGTNSTRRHVEEMVGKSQKAANAAWGMMKRAARDRRDDRIYLMNSLVRSVALYGVETWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MR44</accession>
    <name>A0A8J2MR44_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS11873</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5104180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MR44"/>
    <dbReference type="OrthoDB" id="6420920at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="57"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="105"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="227"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="227"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="255"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5104180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="282" mass="30582" checksum="A8B61918E95E677C" modified="2022-05-25" version="1">MKSLIVVKEYCITQCMLHLRTGISAEKGYFGPWRQCKLLLYNRERCGTGVSRFQPVMVVWVAGIAAAISSGLLGLLVLLAVLQLAMASSAKRMVISYSTTLIGKVALGTLASCLSIVAASLFALQTDDRANSYIITRGEGFYMQRPRNLLKEAKDDVKMERRKQKRGKGIYARRGGDPTKIREVVDVRSTTINNPGYREHSTNGISMTDASGKPYVGGVTNGSMASVTTSGSVGSTISPLRSSLKKPKPLGIQNPGFSTHSPTLSRNGSHKKVRIQTHSTEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MR52</accession>
    <name>A0A8J2MR52_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Similar to lsm14a: Protein LSM14 homolog A (Xenopus tropicalis)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HICCMSTLAB_LOCUS10875</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LSM14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5102158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MR52"/>
    <dbReference type="OrthoDB" id="21539at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033962">
        <property type="term" value="P:P-body assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034063">
        <property type="term" value="P:stress granule assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01736">
        <property type="entry name" value="LSm14_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025762">
        <property type="entry name" value="DFDF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019050">
        <property type="entry name" value="FDF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025761">
        <property type="entry name" value="FFD_box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025609">
        <property type="entry name" value="Lsm14-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025768">
        <property type="entry name" value="TFG_box"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13586">
        <property type="entry name" value="SCD6 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13586:SF0">
        <property type="entry name" value="TRAILER HITCH, ISOFORM H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09532">
        <property type="entry name" value="FDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12701">
        <property type="entry name" value="LSM14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01199">
        <property type="entry name" value="FDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01271">
        <property type="entry name" value="LSM14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51512">
        <property type="entry name" value="DFDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51513">
        <property type="entry name" value="FFD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51536">
        <property type="entry name" value="TFG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DFDF" evidence="5">
        <location>
            <begin position="367"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="domain" description="FFD box profile" evidence="6">
        <location>
            <begin position="430"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="domain" description="TFG box profile" evidence="7">
        <location>
            <begin position="454"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="177"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="227"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="399"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="504"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="FFD box" evidence="2">
        <location>
            <begin position="430"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="TFG box" evidence="3">
        <location>
            <begin position="454"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="229"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="293"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="314"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="326"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="358"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="399"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="504"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="517"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="554"/>
            <end position="566"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG5102158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="566" mass="61586" checksum="CE13BCA97AD9A105" modified="2022-05-25" version="1">MSAGMPELGSKISLISKADIRYEGRLFTVDPQECTIALANATLFIILSNSSLLPRFERIKKENYQSSGISLRSFGTEDRDTQFPVAPQNQIYEYILFRGSDIKDIRVVNNVNTIPNDPAIVQMTVQPTMNQQSYQPQPGYGHPMMGQMPPMAGQYGPPYGMTMGAMGPVMTMPPVRDPRGNMNKPPSELTSGPVDSNVINIPNTLPTANVKPLTKDQSLEDGVMDLISGSRSTTPTSSLLNRKSPTIDQGTQVGHQQKQGSGKAIEKPNNRNVQSQHRDTQSRRSGSGLSHYSDGKRDGSTHDNQMHNQRHSRGSQGSHGPQGTHGPPGGRTGNRGGWVPRGNVSRGRGRGGRGGAFPQNQQGNTGSKPKNTLKFDNDYDFEQANTQFEELRSRLAKTKIDVGTENEKKDDSGNETGAGEGEPEEETDVVHYDKAKSFFDNISCEAVERSKGRSQRTDWRTERKLNTETFGVSSTRRGGFRGRGYYNRGMGGAYRSNNNGAGGHMGGMNPGSGGYRGNYRGNRGNNPANRNKRGQNQGSNSNGGQNGPINNQSTSQSQNRLVTGTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MSL4</accession>
    <name>A0A8J2MSL4_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to NUP98B: Nuclear pore complex protein NUP98B (Arabidopsis thaliana)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS11905</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5104244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="7765355at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16148:SF14">
        <property type="entry name" value="MYND-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16148">
        <property type="entry name" value="NF-KAPPA-B-REPRESSING FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="30"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="147"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="352"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="412"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="610"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="672"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="776"/>
            <end position="871"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="902"/>
            <end position="925"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1057"/>
            <end position="1098"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1252"/>
            <end position="1306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1369"/>
            <end position="1393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1442"/>
            <end position="1505"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1524"/>
            <end position="1566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="352"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="412"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="437"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="462"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="489"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="614"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="625"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="677"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="776"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="797"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="810"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="842"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1057"/>
            <end position="1082"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1083"/>
            <end position="1098"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1442"/>
            <end position="1480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1525"/>
            <end position="1536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1546"/>
            <end position="1556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1557"/>
            <end position="1566"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5104244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="1566" mass="160862" checksum="F225AF02112E03E3" modified="2022-05-25" version="1">MWELTNQDIVIILSVLSGCLIFYNLWGYFIGKILITIAIIYSCIYILINENYNTLLTKINDSIIKAGENIPDLFSLFYHQLLSYLHQFVGFVKKFYQKHFSKMERRGRNSYQLSSESSISMSNNSQLGLMSAVSPIVKNSRRSIVSGSENSVAKRLSPSTSPSSSFGGNKHWENSSYHLNGDINGSMQHLWKKSPSKYSNNDAQDDSLSVRREEILFRSHSTPWNAGLGGKNSSGIKTVQTVAGPLLSSSSDVDTKLLYQSQYSTGQFPKVNLYCSPTPTLNAKTVKARSPVTVRIAPPETIKYSPPEKQKMLANIYRSEKKSPQSVVQVLKEISLKRHASMDDISLELVKKQRTESHREEYESFDEGTQKRTREDLSKSEDDISIENTSLRPVKRTKVPSCYDILSSLSSSTNVMTSSSSGVKRKADLSRSGTPEVGKHFKSFDSNRRSNSVSPRAIINKSSSPSALSRSSSAEFLDACDDDNKKQTADSPKQTSQQSPVSSNSKVNLINNNKLITRNSPQLTQLKDKLFMRAEPQNIDKIKTLIEEHDVTGKFGGDDADEIKQSDILTMRQTSMKARLKSMFDAISGKASSEIDPSVVIQADEVNDRPATSAPISTPVASTAQSQPVLTSLSSSTSTTNVNTSPIATSAIKPIIGKSKDSNTPVKRVTFNLSGETTPTSSTTLVSSSAAPSLQKSEEATNKPSFFQKSQVSTSTFTPASVTSTAFNSVNSATTASGFSLTQAPASTTVQPLTQKTESIISSSFNLQKQVQKPASTCSTNLPSSSPATGFSFGKPATTATTATTATTASTPSENLTSQAPPLSTSSNTFTSNQPPATTSGFSFGSNPPTTTTGFSFGSTPASSAPQTVAPSPAFTAKSPVTTSSSLFSFTPTVSTSVSASTSTSNLAASAPSTTTTASTPGSSSGSGFNFNVAKPTFSFGNTSSPQVTASTPLGFGSQSVAVFRSAAATSTQSTPSFSTPTSQTTTSVPAVLFGANTSTQSSFSSPASTITSTKPSILSFGVPKTTEVPSFGSNTPTTTSSMFNGANQTSSSLMFGGSNSNTASNPSTNTNTNTNTNTGNNLFGQTKSPSFGSQPNLTFGATNSNPTFGNNNTMTFGSQTTTTASFGSTTPATATKAPTFGSSTVASPAFGSTSTSSAGFSGFGGANTSFTQNKTPLLPNTSAVFGSSSSTSSPFGAPAPATTAPPAFGATTTATPAFGSTSSMFGAAPATTATTAPPAFGASSTSAFGSSATSPAFGSIPTTSPPAFGSIPTTTPPAFGSIPTTSPPAFGSIPTTAPPAFGSVPTTAPPAFGSVSTTAPPAFGSIPTTAPPAFGASTATPSFGSSSTPAFGAASGAKPAFGGSAPPAFGATSTSTTPSFGASSAPAPSFGSSAAAPPAFGASNTFGGSSSTPAFGSANTSFSGFGSSSTPAPFGSAVPSFGSAATSNNSNSNNSNNNNNNNNNNSGNNAGAGSFNFGSTNPPAQNPVYSFGGSGTGSSSAGSASTPFQFGNAGASAGTGGFNFNGAGSFNAGSSAAGGGGGMFSIGSGSTAPRTRPARSRRQQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MT46</accession>
    <name>A0A8J2MT46_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9 10">Eukaryotic translation initiation factor 3 subunit B</fullName>
            <shortName evidence="9 10">eIF3b</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Eukaryotic translation initiation factor 3 subunit 9</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HICCMSTLAB_LOCUS7033</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome.</text>
    </comment>
    <comment type="function">
        <text evidence="9">RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex. The eIF-3 complex interacts with pix. Interacts with mxt.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9 10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9 10">Belongs to the eIF-3 subunit B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5093707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MT46"/>
    <dbReference type="OrthoDB" id="10250414at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005852">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031369">
        <property type="term" value="F:translation initiation factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12278">
        <property type="entry name" value="RRM_eIF3B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:001060">
        <property type="entry name" value="Eukaryotic translation initiation factor 3 subunit B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000607">
        <property type="entry name" value="Eukaryotic translation initiation factor 3 subunit B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03001">
        <property type="entry name" value="eIF3b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011400">
        <property type="entry name" value="EIF3B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034363">
        <property type="entry name" value="eIF3B_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013979">
        <property type="entry name" value="TIF_beta_prop-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14068">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 EIF3 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14068:SF0">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08662">
        <property type="entry name" value="eIF2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036424">
        <property type="entry name" value="eIF3b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69322">
        <property type="entry name" value="Tricorn protease domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 9 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 9 10" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="7 9 10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 9 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="RRM" evidence="12">
        <location>
            <begin position="59"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR036424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAG5093707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="696" mass="80707" checksum="6A2307E8899E1809" modified="2022-05-25" version="1">MAVETKMKLNPEDSPNDKDFNDAQPDFSDPEDFVDDIDDEDLLPDILAQKPQETDGIESVIIVDGTPQVEPERFEKFNNLINKLFSKFGTIVNKHYPKNEQGITKGYIFLEYTNKMSAAAAIKARNNYKIDKFHTFKVNHFTDFKKYEKIPEDWEPPAPQPYNAVQDLHYNLLEPDAYDQFAVLAGNGSAVLIQVWLNSAPEPTLIQERAQWTETYFKWSPLGTYMATFHSQGVALWGGAKFDRLARFGQIGVECIDFSPRERYIVTFSPRMDGGADAKRLVIWDILTGQEKRSFVTDGMSTWPIFRWSHDDKYLACMGEDILSVYETPSFGLLEKKSIKTPAIRDFSWSPTDNVIAYWVPEDKDVPARVTLLEIPSRSELRNKNLFNVADCKIFWQKSGDYLCVKVDRFSKKKEKTEQKYTGMSYNFEIFHMREKQIPVDSVEMKEPIHAFAWEPIGSKFAIIHGEVPNVSVSFYEVRCGHQPALLKKLEKRACNHLFWSPAGQFIVLAGMTSMAGALEFVDTKDFSIMNTTDHYQVSDIEWDPTGRYVVTAVSSWKTSVDNAYWIWTFQGRILKRVNLNAFNQLLWRPRPPTLLTADQIKEIKKNLKKYSSQFESKDKMRMTKASKEVIDKRRALMEAFNEYREKRIDEWKGQKKRRMDLRCYVDTDSLESDTKNVEEEVVEFFVKEEIIPIDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MT84</accession>
    <name>A0A8J2MT84_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS13280</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5108523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MT84"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5108523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="83" mass="9845" checksum="6E98F8026E0AB449" modified="2022-05-25" version="1">MTVSMEHKRKTSWDSKTSTNFSIFSNLYSVSIALEYKQRLQCNESWYLWSNHLESNALEIKSPFNSLLLWCTVKVELTFTFRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MTA1</accession>
    <name>A0A8J2MTA1_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Similar to slc7a2: Cationic amino acid transporter 2 (Xenopus laevis)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HICCMSTLAB_LOCUS13310</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5108584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MTA1"/>
    <dbReference type="OrthoDB" id="3900342at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061459">
        <property type="term" value="F:L-arginine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015189">
        <property type="term" value="F:L-lysine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000064">
        <property type="term" value="F:L-ornithine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097638">
        <property type="term" value="P:L-arginine import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43243">
        <property type="entry name" value="INNER MEMBRANE TRANSPORTER YGJI-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43243:SF103">
        <property type="entry name" value="LOW AFFINITY CATIONIC AMINO ACID TRANSPORTER 2-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="47"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="74"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="107"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="141"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="224"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="268"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="6">
        <location>
            <begin position="48"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAG5108584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="286" mass="30233" checksum="FB9B062FB60CEF87" modified="2022-05-25" version="1">MDKLLLYIIETMKKLQLESILNAFTRKKLISSPTESGLARCLSTLDLTALGIGSTLGVGVYVLAGSVAKNLAGPAVVISFAIAAVASMFAGLCYAEFGARVPKAGSAYVYSYVTMGEFTAFLIGWTLILEYVIGSASVVRGLINLGVVVFVVCAGSVKANVDNWKIDTGCKKEPCGPRGTGGFMPYGIEGIIKGAASCFYGFIGFDCVATAGEEAKNPKKSIPIAIVASLTVVFLAYFGVSAVLTTVLPYYEQDPKAPFPHLFDVIGWNWAKWLVSIGAICGLCSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MV39</accession>
    <name>A0A8J2MV39_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Similar to atk: Protein artichoke (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HICCMSTLAB_LOCUS8563</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5097143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MV39"/>
    <dbReference type="OrthoDB" id="6359842at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24366:SF168">
        <property type="entry name" value="GH22922P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24366">
        <property type="entry name" value="IG(IMMUNOGLOBULIN) AND LRR(LEUCINE RICH REPEAT) DOMAINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035275196" evidence="5">
        <location>
            <begin position="19"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="629"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="414"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="494"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="788"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="823"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAG5097143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="894" mass="97801" checksum="ADA0F9850E46739B" modified="2022-05-25" version="1" fragment="single">PSLALLLVLACSLCITAATSPCPWASHITELENSCICDYNLARELSVQCDIVDFNQLLSAIKRYAVRSIVDLFYVNNSTVGVLKNGSFSTIRINNMQLSGCKITSIEDNAFRGQELSLKTLNLKDNELEEIPTSSLRSLRNLTVLDLSLNKITKVEDNAFRTLKLVTLKLADNEITLAPAAFRGLEKTLKNLNLKGTKQKKVPEALRGLKTLAFLDLSQNSIRELPGAAGQKGFEGLDSLTGLNLERNLIQSIGPDAFHGVKNTLSSLSLLNNLIPDFPTAAINSIHDLRVLDIGFNLITELPVNAFANNPSVTLLAIDGNPLSTVPEEALARLNGTLRGLSLGGRFLVCDCKLRWIAQWIRTKDLQVTSREQLMCERPSEIIGIGTVESVDTKEPTGPVTGVVDELLLTTRVSPTTLSSPSSPSSASSLSSFASTTPQKTTQKINTTTIVTTPSTTIELKSTEITTPSTVQVSTTVRPTARTGNVVIVRTTLPPPVRNSEHGSLPQHQPRPPLVLGSPLYKSKAEKDIIVKEALRQDNSVIISWDSETTNILGFRVVYRSFGDTSFKQGPPLEASEREFKIKNVPSQECIVVCVVLLEETNITPANVPYNQCKEVRRENSPTSNIDKLTTIVCAGISMTLILALVIIFIVSRVRSRKLHTLHSIDQTKMGGPISGLPVNCCSNVGPTPSPAGPLASMATLSAYNAQKEWDQVSAYSNRSIPRPRIFPIDRQGSMSRGPCIDEVRSQASHYGGKISSRSVADGQSQHSFGNNSSRYFANTALANNLVNTRPELRQSRQSLAAASDRMSRNGYPGNNNMPPHASARRQRPRSRNRTMEPSHQQQQQPPPPRPGSRYSLADSTHTLNNYEESNWTDHDMDIYMSRNPTTRSGLVPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MV95</accession>
    <name>A0A8J2MV95_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Pleiotropic regulator 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HICCMSTLAB_LOCUS8698</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="4">Involved in pre-mRNA splicing as component of the spliceosome. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Identified in the spliceosome C complex. Component of the PRP19-CDC5L splicing complex composed of a core complex comprising a homotetramer of PRPF19, CDC5L, PLRG1 and BCAS2, and at least three less stably associated proteins CTNNBL1, CWC15 and HSPA8. Interacts (via its WD40 repeat domain) directly with CDC5L (via its C-terminal); the interaction is required for mRNA splicing but not for spliceosome assembly. Component of the minor spliceosome, which splices U12-type introns. Within this complex, interacts with CRIPT. Also interacts directly in the complex with BCAS2 and PRPF19. Interacts with USB1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the WD repeat PRL1/PRL2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5097419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MV95"/>
    <dbReference type="OrthoDB" id="10256122at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000012">
        <property type="entry name" value="Putative pleiotropic regulator 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045241">
        <property type="entry name" value="Prp46/PLRG1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19923:SF0">
        <property type="entry name" value="PLEIOTROPIC REGULATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19923">
        <property type="entry name" value="WD40 REPEAT PROTEINPRL1/PRL2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 7" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="136"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="178"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="220"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="262"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="345"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="54"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00046238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00062641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00073631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAG5097419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="450" mass="49880" checksum="4589050FC0B9265D" modified="2022-05-25" version="1" fragment="single">DVQRHSVHTLVFRSLKRTHDTFLMNQGLLPPIDPELERKKKSIKARDTYGDIVNKVKNQPVKAKNPNENLDPPPPGDESFVGAQSTSLVAVNTPAATPSSAVATSSASNTVAMPVKKTPLMLKPQWHPPWKLYRVISGHLGWVRCCAVEPGNEWFATGSADRVIKIWDLASGKLKVSLTGHISSVRGLAFSNRHPYLFSCGEDRQVKCWDLEYNKVIRHYHGHLSAVYSLALHPTIDVLTTAGRDATARIWDMRTKANVHTLTGHTNTVASVISQAAEPQVITGSHDCTIRLWDLAAGKSRATLTNHKKSVRAVCFHPMLNMFASASPDNIKEWKCPEGKFIQNLSGHNSIVNCLAINPEGVLVSGADNGTMYMWDFRTGYNFQRLQAPVQPGSMDSEAGVFSATFDISGSRLITTEADKTIKVYKEDPNATEESHPINWKPEIIKRRKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MVG2</accession>
    <name>A0A8J2MVG2_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Similar to Rint1: RAD50-interacting protein 1 (Mus musculus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS10133</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5101060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MVG2"/>
    <dbReference type="OrthoDB" id="2189254at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070939">
        <property type="term" value="C:Dsl1/NZR complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060628">
        <property type="term" value="P:regulation of ER to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1420">
        <property type="entry name" value="Dsl1p vesicle tethering complex, Tip20p subunit, domain B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007528">
        <property type="entry name" value="RINT1_Tip20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042042">
        <property type="entry name" value="Tip20p_domB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13520:SF0">
        <property type="entry name" value="RAD50-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13520">
        <property type="entry name" value="RAD50-INTERACTING PROTEIN 1 RINT-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04437">
        <property type="entry name" value="RINT1_TIP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51386">
        <property type="entry name" value="RINT1_TIP20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5101060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="478" mass="55442" checksum="ADC3933994BE2CDC" modified="2022-05-25" version="1">MMDIKQQVIDRFNELLGTDLKNLNKMAQFHEQLQLEKRQIEESLTMASTEAPSKIKAAVANVELIKTDIESSIEINDIESAMSSGNDKTMINSFSNLVEINCQLESSSCQNLVNFVRETLHFWHNHLKEKFSKEYMDVLKNLKWPFCGDNLSTLSSPNSDALTKFKTLTEYLLQLQLPQETDKSSIKSNSLADFLPVSLPIHLLVHPLHQRFTYHFSGNKQTNRRDKPEWYFTQILSWIKDHESWIEKNVQPVLNSSEFSYINAKVEFMRALVKLAVEKLQTDLPIVQYDDALFAHFVDEALAFERDLRENLFYPPNQPATVSVLTQAQSFVKWINMEKKYATEKMDAILSAPSAWERITVANVEDMKVTECAEAFLTLLTTMNERYSHLPQPGHRLQFLELQLELIDDWRVRLLQLLHQSCEDPLHSLIPSILNSVNYVLNILMEWGVTVVCIQYLYYIYQILVAPKFLLQIQNKNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MVP3</accession>
    <name>A0A8J2MVP3_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ribosomal protein 63, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS9091</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5099503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MVP3"/>
    <dbReference type="OrthoDB" id="6019958at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005761">
        <property type="term" value="C:mitochondrial ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016576">
        <property type="entry name" value="Ribosomal_mL63"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14520:SF4">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML63"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14520">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOMAL PROTEIN 63"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14978">
        <property type="entry name" value="MRP-63"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5099503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="107" mass="12949" checksum="FEF1D739E6ADAB0E" modified="2022-05-25" version="1">MHLTALLMLSKRKPPHGIKYRGKNRVVPKPKMEHLFMLRHRLERDEENMLILRHPYLTSEQSRDYMKDLKVPVPLSVVGNRKRNELFNKHFSWVDQLAHLRVRDAWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MW95</accession>
    <name>A0A8J2MW95_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Serpin.4_Cc</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HICCMSTLAB_LOCUS10374</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the serpin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5101301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MW95"/>
    <dbReference type="OrthoDB" id="671595at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004867">
        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19601">
        <property type="entry name" value="serpin42Da-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.39.10">
        <property type="entry name" value="Alpha-1-antitrypsin, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.497.10">
        <property type="entry name" value="Antithrombin, subunit I, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023795">
        <property type="entry name" value="Serpin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023796">
        <property type="entry name" value="Serpin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000215">
        <property type="entry name" value="Serpin_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036186">
        <property type="entry name" value="Serpin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042178">
        <property type="entry name" value="Serpin_sf_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042185">
        <property type="entry name" value="Serpin_sf_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11461:SF211">
        <property type="entry name" value="GH10112P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11461">
        <property type="entry name" value="SERINE PROTEASE INHIBITOR, SERPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00079">
        <property type="entry name" value="Serpin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00093">
        <property type="entry name" value="SERPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56574">
        <property type="entry name" value="Serpins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00284">
        <property type="entry name" value="SERPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0646">Protease inhibitor</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0722">Serine protease inhibitor</keyword>
    <feature type="domain" description="Serpin" evidence="5">
        <location>
            <begin position="26"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAG5101301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="390" mass="44163" checksum="80F238CC3705D1E1" modified="2022-05-25" version="1">MRLNLSSDDKRHAVRAVSASINQFSSEFYETVSKDVVDNFICSPLSAAMVLMMASYGARGKTAEEMTKALHLNYENYVQKTGINFLIDNFNTIDKAQVKLANKIFVTNVVPIKPAFINITESTFRSVAESLDFMNAEASSQIINNWCEKETHSRIKDVVQPGDLNADTALVLVNAIYFKGIWADKFIENETHPRTFHLDEQRTKMVPMMHRLANYRYGILPELNARFIEIPYESTDLTDSLSMIIILPDEITGLGDIEAGLHKLKFERLLSGEQFEIDLFLPKFKIESKIDLKKPLNALGMNQMFEDTANFTGIMDVPPLKVSKIVQKSFIEVNEEGSEAAAATVFDLQNRLGFSDSSLKRAHFIVDRPFFFQIVSEHIVLFSGHIKDII</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MWY3</accession>
    <name>A0A8J2MWY3_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Elongation of very long chain fatty acids protein</fullName>
            <ecNumber evidence="10">2.3.1.199</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Very-long-chain 3-oxoacyl-CoA synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HICCMSTLAB_LOCUS10962</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a very-long-chain acyl-CoA + malonyl-CoA + H(+) = a very-long-chain 3-oxoacyl-CoA + CO2 + CoA</text>
            <dbReference type="Rhea" id="RHEA:32727"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:90725"/>
            <dbReference type="ChEBI" id="CHEBI:90736"/>
            <dbReference type="EC" id="2.3.1.199"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the ELO family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.199" evidence="10"/>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5102332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MWY3"/>
    <dbReference type="OrthoDB" id="434092at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009922">
        <property type="term" value="F:fatty acid elongase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034625">
        <property type="term" value="P:fatty acid elongation, monounsaturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034626">
        <property type="term" value="P:fatty acid elongation, polyunsaturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019367">
        <property type="term" value="P:fatty acid elongation, saturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030148">
        <property type="term" value="P:sphingolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042761">
        <property type="term" value="P:very long-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002076">
        <property type="entry name" value="ELO_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11157:SF162">
        <property type="entry name" value="ELONGATION OF VERY LONG CHAIN FATTY ACIDS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11157">
        <property type="entry name" value="FATTY ACID ACYL TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01151">
        <property type="entry name" value="ELO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="5 10" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2 10" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="7 10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="34"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="63"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="117"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="147"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="171"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="205"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="235"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAG5102332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="324" mass="38453" checksum="4CE1426ECCD98DE3" modified="2022-05-25" version="1">MTTAIENLVHGYRDVIDNRSDPRVKDWPMMNSPLPTMAICLFYAYFSKVLGPKLMENRKPFNLRSILVGYNFIQTLFSTWIFYEYLMSGWARGYSFRCQPVDYSNNPMALRMVNVCWWYYFSKFTEFFDTLFFILRKKNQQVTTLHVIHHGVMPFSVWMGLKFAPGGHSTFFALLNAFVHIIMYFYYMIAAMGPEYQKYIWWKKYLTTFQMVQFVLIMSHQFQLLFIECDYPRSFMIWIGLHGVLFLGLFSDFYKTKYSSNRLKVKLSNNGTCMPVLDDNEYKIQQNGNSIYTTTIYKKEYNKSYTNGTNNGYVVNNNTEKKLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MXA2</accession>
    <name>A0A8J2MXA2_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS10408</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5101335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MXA2"/>
    <dbReference type="OrthoDB" id="10064012at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="105"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="275"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="476"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="17"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="131"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="275"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="307"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="318"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="356"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="480"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="559"/>
            <end position="569"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5101335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="588" mass="64906" checksum="5239F03068FC283D" modified="2022-05-25" version="1">MNDKRARLEKFTPKNADSSSSSCSTSSFSEDETDDKPLKPIKDYLYNRKEIELEELCVNELCGMSKSRVLSILNGKQMLDSSNTSESDDSGPSLEIISDTEAWITDSELPDDKDKVSASKSRKVKTKKIKKEPTASDKQAKTNSQNKNKSARKQTADLVKVKNEKESKSQPQQGESLLDLLELEMRARAIRALIRKEEDIIPNESTTSKISVNVNSLLDQANISLAVGLGNNSTKEADKSSARSKVEEAVSLSLNSNEDEDVVLVVKPTPTINLLSSDSEAEDSNVNISKSNGEKIETSTECSLTDKNNKENQDKLSDSLNINKINQANDVNNKSSGGTNSESKDKSQDSAITKVPSDKSSELYKEKSKKINEPSKVLEESSSNSIILHDEDEIIDLDNYSDDMDEIENDKIIESSVKNNPSKVEVKFTVESNSTESSSLDSSETWATRYYQTDNVQSVIKESKIQSEIRKRLRERQKLSKLNNNSNNNGNSASKESVIKSNAVEKPIEPDNSKPTGSVEEYLALKRVSSPDVKSTVCEQNPTDVKVDNIPGEKIFPVTTENIDQSAGDESTIEQPHVSPSIPVQENS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MXM5</accession>
    <name>A0A8J2MXM5_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS11720</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5103859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MXM5"/>
    <dbReference type="OrthoDB" id="10022757at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029195">
        <property type="entry name" value="HCFC1R1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16246">
        <property type="entry name" value="HOST CELL FACTOR C1 REGULATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16246:SF2">
        <property type="entry name" value="HOST CELL FACTOR C1 REGULATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="224"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="237"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5103859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="286" mass="32426" checksum="9FB7E8BE6497EADF" modified="2022-05-25" version="1">MTMPTQFQVIHPPAQNQMPGAHMHTPPSIFEHMMGQQNAPHEPGSWSQMPQIPPMYMPWSIPSMQQSQMMRFTGEKPSFVPPAPAPVHQKRKLDIPDIPETRPTKQFISEEKMAAHFRNMHISSNYNPIPSCSSSTDYNVQPSTSSQVDLNVESSTLNVENSKSMHPRLVISEELRRIQQEPLIPTSLLSKFFDCRERPSMALVLWEPPSKHLRTFITQAGIQLPPTSANSNEEDNNNNSNNNNNNNNNYNNLNLNNNNNNNNSQSMPNLNQPLEPGNLELEPMDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MYD3</accession>
    <name>A0A8J2MYD3_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Similar to SCARB1: Scavenger receptor class B member 1 (Sus scrofa)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HICCMSTLAB_LOCUS11529</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CD36 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5103477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MYD3"/>
    <dbReference type="OrthoDB" id="18585at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005044">
        <property type="term" value="F:scavenger receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002159">
        <property type="entry name" value="CD36_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11923:SF67">
        <property type="entry name" value="RE68569P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11923">
        <property type="entry name" value="SCAVENGER RECEPTOR CLASS B TYPE-1 SR-B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01130">
        <property type="entry name" value="CD36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01609">
        <property type="entry name" value="CD36FAMILY"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0675">Receptor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="72"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="508"/>
            <end position="530"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAG5103477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="598" mass="68749" checksum="4773316DE528EA5E" modified="2022-05-25" version="1">MKDLMSIWSQLAGRRYTSVHVNANHQVSSQNPEDSSDSDPSSLQSKSAIVVNQFFNNTLPVRSNSRRRWPRSIFTLMSLGLLGLTFGLLTFVIQPYELLFKLKVTFSNNGEIFELWRKPPVDLYLKVYLFNVTNHDRYMSGVDSKLRFQEVGPYVYKENLEHSNITFNDNGTVSAIPRHPLTYVPELSGGTEDDILYLPNIALLSIANVMRDASIITTWPLNALIKQTDSRPLVQMTAHEFMFGYKSSLVTLGNTFLPSWIKFEKLGLIDRMYDFDGDFETVYTGENDVRKTGLIDKYRGDVNLPQWTGKCANVNGASDGAKFPSYIEPNDTLLFYRKSLCRSAKMVRTGEKDVKGLHTYKYKFMDNELDNGAKNTDNKCFCREGRCLQEGLIDVTDCYYGFPIALSYPHFYESDPSLLEKVKGLEPKKDKHESYFYIQPKSGLPVDLAFRFQINMALQDISSISNVEGFSELVLPLLWFEIGMYELPESMNNRFILYLNVLPVVQDVAIYALFLGGIIFLVWSIVKIMLYRPRGSPARPGQWFESDLQRKRLNFFNEKRNSFRAKPMDTYYNSLLEPKEEMTPMTAMVNTEFKEDLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MZ54</accession>
    <name>A0A8J2MZ54_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Similar to ken: Transcription factor Ken (Drosophila pseudoobscura pseudoobscura)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">HICCMSTLAB_LOCUS13735</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5109099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MZ54"/>
    <dbReference type="OrthoDB" id="8117402at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18315">
        <property type="entry name" value="BTB_POZ_BAB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002034">
        <property type="entry name" value="transcription factor Ken"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002059">
        <property type="entry name" value="transcription factor Ken"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051497">
        <property type="entry name" value="Dev/Hematopoietic_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45993">
        <property type="entry name" value="B-CELL LYMPHOMA/LEUKEMIA 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45993:SF7">
        <property type="entry name" value="TRANSCRIPTION FACTOR KEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="BTB" evidence="12">
        <location>
            <begin position="32"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="388"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="416"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="115"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="186"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="315"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="115"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="139"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="210"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="225"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="368"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CAG5109099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="484" mass="53233" checksum="9357C2CBE432C6AE" modified="2022-05-25" version="1">MYTDGLLTLHYGKHPATLAAEVGAWYSGDRHVDVTLACDDGSVVRAHRVVLAAASPFLASLLRNPALDHVVHLSGVRKTQLTHLLEFLYNGEALIPSSELTPLRELFELLQIKSESFDPNQPQTSTDSDSLRIPTPQPSESQESSSYESQYDSRSQSNNPADCCSVLIKSEGCDDDPEQDVDVEGVEGDAILTDNGESSIEPPRRRDSSDPVNLSLNSGTSTKSDGSHELSHLRSEKMLLERRESLEEAEERRRQLAARLSLGLEPGKRKPEEIPLPPAEAYVVTPHRKRRPGFHNAPAQNPAFVPFNPGFETPRRLAAPHPLSVSAPPYLQDRSVTPPGASHRPPSADPASAAGLEPPWGAWTLPPARAPPPPSAEDPPKCTPVREYRCTYCGKQFGMSWNLKTHLRVHTGEKPFACRLCVAMFKQKAHLLKHLCSVHRGVIAAPDNTFTCCFCSLSFDSLQELIRHLSGPHNNLLLSKNLHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MZ63</accession>
    <name>A0A8J2MZ63_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">tRNA-intron lyase</fullName>
            <ecNumber evidence="2">4.6.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HICCMSTLAB_LOCUS12434</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>pretRNA = a 3'-half-tRNA molecule with a 5'-OH end + a 5'-half-tRNA molecule with a 2',3'-cyclic phosphate end + an intron with a 2',3'-cyclic phosphate and a 5'-hydroxyl terminus.</text>
            <dbReference type="EC" id="4.6.1.16"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the tRNA-intron endonuclease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.16" evidence="2"/>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5106786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MZ63"/>
    <dbReference type="OrthoDB" id="48041at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000213">
        <property type="term" value="F:tRNA-intron lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000379">
        <property type="term" value="P:tRNA-type intron splice site recognition and cleavage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22363">
        <property type="entry name" value="tRNA-intron_lyase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011856">
        <property type="entry name" value="tRNA_endonuc-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036167">
        <property type="entry name" value="tRNA_intron_Endo_cat-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006677">
        <property type="entry name" value="tRNA_intron_Endonuc_cat-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059049">
        <property type="entry name" value="TSEN34_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13070:SF0">
        <property type="entry name" value="TRNA-SPLICING ENDONUCLEASE SUBUNIT SEN34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13070">
        <property type="entry name" value="TRNA-SPLICING ENDONUCLEASE SUBUNIT SEN34-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26577">
        <property type="entry name" value="TSEN34_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53032">
        <property type="entry name" value="tRNA-intron endonuclease catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="TSEN34 N-terminal" evidence="6">
        <location>
            <begin position="2"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00034031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF26577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAG5106786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="242" mass="27768" checksum="D281CBDB03427BE6" modified="2022-05-25" version="1">MIDLVMSHGNVFVWSAEDWLTLRREHRIVGATIGCPHTLPRQEIMQGLPLMILPEEVTLLLENKIARLVEYPSLRQEPDDDMRKVFENFRKKMFKEQETALKDGKKKLILGKIDSIIEGKKRKSLGLKTSKKSMKKTLDDATAEAVKRVEIDRDALVAEQLSKCPNLDPDDALVQIHTSDPVMFHSQFIVSCMDIDEEIPILNLTGQCRVACHVRKTQVYAYFSDDNKIAYQSFQYDNSNMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2N0B9</accession>
    <name>A0A8J2N0B9_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS13495</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5108859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2N0B9"/>
    <dbReference type="OrthoDB" id="7726766at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5108859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="179" mass="20395" checksum="67B42F119D782E9E" modified="2022-05-25" version="1">MNNQEDGMVEMYAFIVRDEKIPACCRPASPITNESFLTGVIEMPKLPKGIYDDVGHMCCSQKCQLLTVIQRVNNHHLIKPIEAQHLPPPVHDDDSLMTVPRHDLKERIAANLMQVDEKLTSIDWSKIEEETKPKVRVTDQEKIEKFAKEIVDETMGRLEEVLETNVTSDVGAKHKDTCM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2E2W6</accession>
    <name>A0A8J2E2W6_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS1605</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001116">
        <property type="protein sequence ID" value="CAG5075451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2E2W6"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5075451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="141" mass="16781" checksum="A4597C5ECC7B0A93" modified="2022-05-25" version="1">MNNQNDIMNLLREMFNILPSRGYFYQRNNSFYGYVCETYGHQRYGEKNYYIFTVNGWDSFNYLFAIENASFTECLKINKNQILHISNAADFICHFPSINDEDLSTSKFLTTFNQITFFNEFVVEELPILATQKMTIEDEYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2E4F0</accession>
    <name>A0A8J2E4F0_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Similar to Sh: Potassium voltage-gated channel protein Shaker (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HICCMSTLAB_LOCUS126</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030000732">
        <property type="protein sequence ID" value="CAG5071977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2E4F0"/>
    <dbReference type="OrthoDB" id="415460at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008076">
        <property type="term" value="C:voltage-gated potassium channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005251">
        <property type="term" value="F:delayed rectifier potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001508">
        <property type="term" value="P:action potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.930">
        <property type="entry name" value="Mammalian shaker kv1.2 potassium channel- beta subunit complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003968">
        <property type="entry name" value="K_chnl_volt-dep_Kv"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028325">
        <property type="entry name" value="VG_K_chnl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11537:SF113">
        <property type="entry name" value="POTASSIUM VOLTAGE-GATED CHANNEL PROTEIN SHAKER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11537">
        <property type="entry name" value="VOLTAGE-GATED POTASSIUM CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00169">
        <property type="entry name" value="KCHANNEL"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01491">
        <property type="entry name" value="KVCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0630">Potassium</keyword>
    <keyword evidence="5" id="KW-0631">Potassium channel</keyword>
    <keyword evidence="3" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Ion transport" evidence="11">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAG5071977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="94" mass="10699" checksum="62352C934013D18F" modified="2022-05-25" version="1" fragment="single">MNFIDIIAIIPYFITLGTVIAGKEHEFDLPKAPVSPQDKSTNQAMSLAILRVIRLVRVFRIFKLSRHSKGLQILGRTLKASMRELGLLIFFLFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2E9H9</accession>
    <name>A0A8J2E9H9_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Similar to Znf532: Zinc finger protein 532 (Mus musculus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HICCMSTLAB_LOCUS851</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001114">
        <property type="protein sequence ID" value="CAG5074079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="8856548at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050888">
        <property type="entry name" value="ZnF_C2H2-type_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24406">
        <property type="entry name" value="TRANSCRIPTIONAL REPRESSOR CTCFL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="60"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="864"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="1401"/>
            <end position="1429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="256"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="316"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="276"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAG5074079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="1536" mass="174080" checksum="A95E20943DEA7E0D" modified="2022-05-25" version="1">MTEFARTVPRIKKSKSTFKWGQQYYTALQDAVFPVKHNLYSTPEIPSKLADNIDVKKGKYSCHQCGDSFHFQSSLDDHLARYSWILGYWCRHCTKLECTHQKAPRSNSSSSISCPECKAELKKRCAYFKVRGLTGGERVGKILIFYNQCQFFGHLKDHGITAVDMCDMMLMPIPMTIQSDEYAQLDSVSRTLFECMFIKNIHIMDWLRLENVNFKWWTVTGSDDNAVGKLIRQHEFDIVRANRLIKSVKDHELAAINNVQDPEEDNDSNTDNSSIKNEEKSPVKGISDNHCDLNEIEFVDCASLDDSLVTEEPPIAAPPVAVKTEPPSSSEPTTGELLKIINKPSAKLANLADINSISLNRNTVTHLINRNLKISSSNTLQTTTLTNITGAGKKNQIIIINKNKDSDKSNEVKANVQILSNSGQDTVKFFKQAGGGRVFFQPGMKPVILKQIPKPLNATKLDGEKKYTVPKFSVVKNKLKILSGNSVPVTLVTSAQMLKSVSTLTTASSTLATPTAPKQTVLKIRDGSGLKTISVAQEKCTKLIPMEALHKPKEVLQKEMELLQKKSVNITGQIRQKSLINYTPQTVQLSSIPKGTKIVQTIQAGPKLVPVTQSSVKFPRPVQTYQKLQTVAKIGQNSGQKTGTKIGKTLLKPIESLLKPEAQTKELKDTLVKKVEEDPLSGEVFSPQVQKVDRGQSVLKLCSPDKKQNAVRAYREAMILSFQQSRKRVKPLIDNIMETNEIYDKTNVDVHSVKTVNEMALSKLKIYLDNDRNVKMTDDDKINEELHHHSDNWEAKADSSNKYCERCHLKLKPQNYIVGISDPSDQEDIYCQCYNHVCHLCNARQGTLARYNVHMCFHMKEFPYTCPECFKKFPSIQHLEMHIWQQCYHIKTHQSWTCNVCEIEGFLTKEHLARHYFKIHSKSVSFCNFCRKKFDSFSEFKAHNSEIHGIINTQFSNENRLIKCDFGECLTKPEAYSEHVAAHVTVDKVTHYICPFCNFSMGEISINGHLIQRHVFKAHPERLKEVITNETLSVFIKMNLVSPQAIDRPPSPSIKIVNAFPISSKAFNQQATNSVEIINRRSESMPIKIIDVRTEKADEPVNHKLEEDVTELPGSSLKIIDVTSMSKGEYSDDSNEDDDKNKMIKNSIEKLSKLGVSLSAIKKNDKPRKAEEVGTHDEVSIINNFSRRKSSPPPLVLINNVNLLELDKEDDKKDVVQIDCVNDNKVMIRNDLFNLEGVSIQRKSFGKKKQRLAMNGPLFKKEMVHYRCHLCGELINTNWYVINDHFRECHSAGYRIVSMTPCLRRLTSFEIMKYTGMKRGSSDLILTPKKRRRGNYGPLFSNGKRLVDKFGGNNLGFCVTQESLQDVEGNFKCKKCDCLFKDVNVLREHLASNHRIRGHYLVCLECGDNFIVASTLQMHLKAFHGINDPISYLQKNTAYAPDALDEIEEQDKITESNQCYVCFAVFENKLAVDMHLRVHGMAFLNRKRIEARKALKCPQKFKAASLTPKPEEIKIDDCEDDNANVSILTRISRLLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2EAG8</accession>
    <name>A0A8J2EAG8_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Similar to Smc1a: Structural maintenance of chromosomes protein 1A (Mus musculus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HICCMSTLAB_LOCUS530</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SMC family. SMC1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001114">
        <property type="protein sequence ID" value="CAG5073626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2EAG8"/>
    <dbReference type="OrthoDB" id="413649at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008278">
        <property type="term" value="C:cohesin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007062">
        <property type="term" value="P:sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03275">
        <property type="entry name" value="ABC_SMC1_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1060.20:FF:000001">
        <property type="entry name" value="Structural maintenance of chromosomes 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1060.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003395">
        <property type="entry name" value="RecF/RecN/SMC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024704">
        <property type="entry name" value="SMC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028468">
        <property type="entry name" value="Smc1_ABC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010935">
        <property type="entry name" value="SMC_hinge"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036277">
        <property type="entry name" value="SMC_hinge_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18937:SF12">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18937">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES SMC FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06470">
        <property type="entry name" value="SMC_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02463">
        <property type="entry name" value="SMC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005719">
        <property type="entry name" value="SMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00968">
        <property type="entry name" value="SMC_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75553">
        <property type="entry name" value="Smc hinge domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7 10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0498">Mitosis</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SMC hinge" evidence="12">
        <location>
            <begin position="421"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="305"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="759"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="70"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="337"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="577"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="901"/>
            <end position="970"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAG5073626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="1132" mass="131276" checksum="D1041410C2EFC9A1" modified="2022-05-25" version="1">MNRIMISDDFYTGGLLILIVVTSQVYLSELEHLGINVKAKNFLVFQGAVESIAMKNPKERTALFEEISNSGALKAEYERLRSEMLRAEEETQFSYQKKKGIAAERKEAKLEKEEAEKYQRLKEEYVEKQIELQLFRLYHNERDIEDLENTQKKRQHDLDKIEKKKEKAEEVLKDRKKELGKLTRELAKIEQDIREVEVEITKKRPTFIKAKERVAHMQKKVESAHKSLQQARAADEAHKKDIAELQEELRQVEEAKAAYEASIAGQSQQQGRDVQLEDEQVSEYNRLKEEAGKQSARYLQMLDSINREQKSDQDRLDNESRKRTEIENKFKQKGHIRDDQLKRVEKLEEHIKTSEAALEEQKKLRADLQNDVGSSKDTVQRLQRELENISEQLGDAKVDKHEVARTKKKTEIVENFKRLFPGVYDRMYNMCEPIHKRYNVAVTKVLGKYMEAIVVDTEKTARSCIQYLKEQYLEPETFLPLDYIQAKPLKERLRNIKEPKNVKLLYDVLHFSPKDIDRAVLFATNNALVCETPEDANKVAYELDKKTRYDCVALDGTFYQKAGIISGGSLDLAKKAKRWDEKQMAQLKAQKEKLTEELRECLKKSRKESELNTIESQIRGLETRLKYNKSDLLGTKKQIADCDNEVKELQSELDQFEPTIAVIEKTMAARDQEIQNIKEKMNTVEDDVFTSFCEQIGVSNIRQYEERELRSQQERAKKRMEFDNQCNRIQNQLDFEKQRDTESNVLRWERAVQDAEDKLESAKQTEANQKSEIDNDETQMEKLKSQRNTKKMEVDAKEEEIGKCRRDVGAIAKDLQGVQKQLNNIETKIEQRRADRHAILMHCKMEDIAVPMIRGNMEDIAGDANNDTNNETLSTQQQYERESRITIDYGTLPDNLKEIEDDEFKKTMDKINKAINDLQNNIQRIQAPNMKAIQKLYLAKEKLQETNEEFEQSRKKAKKAKTLFEKVKKERHDKFMACFEHVANEIDPIYKSLAKNQSAQAFLSPENPEEPYLDGINYNCVAPGKRFQPMSNLSGGEKTVAALALLFAIHSFQPAPFFVLDEIDAALDNTNIGKVASYIRDKTSSLQTIVISLKEEFYCHADALIGICPEVGSCLESKVLTLDLTTFPMNVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2EDE8</accession>
    <name>A0A8J2EDE8_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Protein neuralized</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">HICCMSTLAB_LOCUS2005</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Involved in neurogenesis. Interacts with other neurogenic proteins in the specification of the neuroblast versus epidermoblast cell fate.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001116">
        <property type="protein sequence ID" value="CAG5076024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2EDE8"/>
    <dbReference type="OrthoDB" id="6078042at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007399">
        <property type="term" value="P:nervous system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16647">
        <property type="entry name" value="mRING-HC-C3HC5_NEU1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000441">
        <property type="entry name" value="Neuralized, isoform B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.920:FF:000005">
        <property type="entry name" value="Putative E3 ubiquitin-protein ligase NEURL1B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037962">
        <property type="entry name" value="Neuralized"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006573">
        <property type="entry name" value="NHR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12429">
        <property type="entry name" value="NEURALIZED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12429:SF6">
        <property type="entry name" value="PROTEIN NEURALIZED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07177">
        <property type="entry name" value="Neuralized"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13920">
        <property type="entry name" value="zf-C3HC4_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00588">
        <property type="entry name" value="NEUZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51065">
        <property type="entry name" value="NHR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0524">Neurogenesis</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="NHR" evidence="15">
        <location>
            <begin position="123"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="domain" description="NHR" evidence="15">
        <location>
            <begin position="353"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="14">
        <location>
            <begin position="694"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="507"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="592"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="519"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="605"/>
            <end position="621"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00058903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00068495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CAG5076024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="747" mass="81323" checksum="4328560183E99661" modified="2022-05-25" version="1">MGVVGGECAVKGTGVKSHPCHCCGSTRISTTVGPSVVIQVHKHRRSSRKSQSNLNNNHINHHQDNSLVFVQEPEVPPTNSPTTTSTDNILAPLKSKMKVLKKLKRKMGLAPRSSNTGTNNLPPLTFHQVHGENIRLCNGATIARRHESFCKGITFSARPVRVGEKVCVKFLEMSNNWSGVIRFGFTSNDPVHLRNGLPRYACPDLTNKPGYWAKALAERFAGRDTVLFYYVTAAGDVHFGVNGEEKGVFFSGVETRGPLWAVIDVYGNSTAIEFLDPNRQHFNNIRRGVEHSNEDNAQPSRHTAMDDASNAGRDIVEKIIVPTMQNMVLHHGPEPDVDLPGLRFQPSGVLFAPLPFHPVRGRNIRFSNQQCVATRNDTEFCHGYAFTNRPLILGERLVVQILSTEPMYVGALALGLTSCDPARLTAEDLPDDSDLLLDRPEYWVVSKDVASSPQPGDEIAFTVTHYGEVQMSKNGGPPNIVMHVDQSLQLWAFVDVYGSTQRVRMLASRPSSPPRQRQATAVAPSNPVSVPVAPTTPAATHPATPQPLVTPHQNHQGHVTELTRYPDMVQVKSGIGGQTVLVVNLPPQQNYPPASPPIYGSTNRSPGFYPSGSSTGPTGSTGSTGGNPVAASTPRASPPVLTGTMSSTGSSTYVDPVTYQAIDSSTLTLQGTGNPHLQQWSEKLQPTPGQPSECSICYERNIDSVLYMCGHMCMCYPCAIQQWRGKGGGQCPLCRAQIRDVIRIYRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2EDL4</accession>
    <name>A0A8J2EDL4_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS2110</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001116">
        <property type="protein sequence ID" value="CAG5076129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2EDL4"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5076129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="201" mass="23489" checksum="50650BD3C9E7D531" modified="2022-05-25" version="1">MSQTHVLHAHFLKRIYGLIRHRNTIDLFYFIEYMEGRLFIAGRWFKYASTRNEFDSRHKTESLSEIESKVTFNKEDYMLISGNVKSVAVYTREKNPRVDVMERARLVVSAKNGISVADLKKFNHKGSGLSFRFRTLKNYHGLVGVLLKLYQPDSGDIFDIHVSILALDVISAVEVRKQRRRSYPRRFFSVNFVACYIVSLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2EDM3</accession>
    <name>A0A8J2EDM3_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS1593</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001116">
        <property type="protein sequence ID" value="CAG5075439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2EDM3"/>
    <dbReference type="OrthoDB" id="8046116at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37162:SF1">
        <property type="entry name" value="BED-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37162">
        <property type="entry name" value="HAT FAMILY DIMERISATION DOMAINCONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="26"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5075439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="241" mass="27598" checksum="6B56F974D3840980" modified="2022-05-25" version="1">MDRWLKKNPSQGPVTPNLSDICNIVSLPSPSSDSETDSSATIKKVKVKRLSQSQRSSKQTKNKFQRSWLQDEEFKGWLMKYDKTKNGNEMAFCKICDKILTCHRNDIRRHKNSHAHKDNSTGIQISQKMPEKCKFETSVRKAELLFAGILVSQNIAFSFMDVLSPCLAKAFPDSEIAKKFSMRRTKVTQIINNVLGSNLKEDLYQQLQTLGCFYSVIMDETTDETTTKQCAFTVIFFDEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2EG95</accession>
    <name>A0A8J2EG95_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to FGF17: Fibroblast growth factor 17 (Homo sapiens)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS1008</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the heparin-binding growth factors family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001114">
        <property type="protein sequence ID" value="CAG5074300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2EG95"/>
    <dbReference type="OrthoDB" id="5988014at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008083">
        <property type="term" value="F:growth factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23307">
        <property type="entry name" value="beta-trefoil_FGF8-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002209">
        <property type="entry name" value="Fibroblast_GF_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008996">
        <property type="entry name" value="IL1/FGF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00167">
        <property type="entry name" value="FGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00442">
        <property type="entry name" value="FGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50353">
        <property type="entry name" value="Cytokine"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="156"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="256"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="156"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="197"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="256"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="273"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="290"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5074300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="300" mass="35346" checksum="2235147CDCEBD511" modified="2022-05-25" version="1">MVVMCGAVPAMVRSVSLYSTCSSGNITVIGRNVKASARDQDNAPYQKLTTQSDDFSRKLYIFAEKSQRFICFNKRWKPIALPKKQRDAMCQFYETYNGPYLRYRSAVDPTKYLGFNKYGRPIKGQRARPECYNFMKYNPSFSINDHNDWMTGNTRVRELHKPPHPHPHPEHAHKEPLRVKKTKKSPRRQNLNSNFESKQDLDVSDPPQRDMSRPLDLFEKNPDEFLRPPQFLEPEFSLKKKKLLLERDVITYQRNSELEMARQSRKNHLQEPHRHRHTSRGKGKSGDTRTRRHRLPASKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2EGI0</accession>
    <name>A0A8J2EGI0_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ADP-ribosylation factor-like protein 6-interacting protein 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HICCMSTLAB_LOCUS1159</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus speckle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ARL6IP4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001116">
        <property type="protein sequence ID" value="CAG5074948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2EGI0"/>
    <dbReference type="OrthoDB" id="48562at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019532">
        <property type="entry name" value="Nucl_RNA-splicing_assoc_SR-25"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10500">
        <property type="entry name" value="SR-25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="28"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="56"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="72"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAG5074948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="153" mass="18266" checksum="CF805E08F289DE7A" modified="2022-05-25" version="1">MDKSPEEKPKKRKRSSSSSSGSDSEKEKRKRKKQYKKDKRKIKKKMKKLKKKLKRKEKEVIKDAEEQLEVIEDNKSDQEDKTEVRSMAPMTKEEWEKRQSVVRRVLDESTGRYRLIKGDGEVIEEIVSRDRHKEINKQATKGDGNYFQSFFKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2EIY4</accession>
    <name>A0A8J2EIY4_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to Blos2: Biogenesis of lysosome-related organelles complex 1 subunit 2 (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS809</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the BLOC1S2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001114">
        <property type="protein sequence ID" value="CAG5074037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2EIY4"/>
    <dbReference type="OrthoDB" id="244061at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031083">
        <property type="term" value="C:BLOC-1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099078">
        <property type="term" value="C:BORC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000930">
        <property type="term" value="C:gamma-tubulin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043015">
        <property type="term" value="F:gamma-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016197">
        <property type="term" value="P:endosomal transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032418">
        <property type="term" value="P:lysosome localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019269">
        <property type="entry name" value="BLOC1_su2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46479">
        <property type="entry name" value="BIOGENESIS OF LYSOSOME-RELATED ORGANELLES COMPLEX 1 SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46479:SF1">
        <property type="entry name" value="BIOGENESIS OF LYSOSOME-RELATED ORGANELLES COMPLEX 1 SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10046">
        <property type="entry name" value="BLOC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="13"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="35"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5074037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="135" mass="15375" checksum="887E1A3E775A72D3" modified="2022-05-25" version="1">MTTNSNEITEEMQDNKPHFIDTPEHDHSRCHSPKHGTTLSTSTSSFEALDPHDPNLSRLATTMFEKTAEYLQDELTSTHADYRLLERLNKETIAKYAELKTISTNVSQSLDALNQKYKKLQPVLDNINQIDDNVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2EMX6</accession>
    <name>A0A8J2EMX6_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Similar to TBCK: TBC domain-containing protein kinase-like protein (Gallus gallus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HICCMSTLAB_LOCUS1150</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001116">
        <property type="protein sequence ID" value="CAG5074939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2EMX6"/>
    <dbReference type="OrthoDB" id="1668230at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.80:FF:000015">
        <property type="entry name" value="TBC domain-containing protein kinase-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.270:FF:000044">
        <property type="entry name" value="TBC Kinase homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22957:SF168">
        <property type="entry name" value="TBC DOMAIN-CONTAINING PROTEIN KINASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22957">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="Rhodanese/Cell cycle control phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="Rab-GAP TBC" evidence="3">
        <location>
            <begin position="393"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodanese" evidence="4">
        <location>
            <begin position="675"/>
            <end position="774"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAG5074939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="1006" mass="114835" checksum="7AE0E44792B0F57D" modified="2022-05-25" version="1">MCPAILDSEERCLGGMTFFAQSHPTELCGSNGLPLTPNSITIYGKAQFLKTVRHRNLAPYLDIIRSKHERTIVVAEYTGSPLSGHIGDESFSWETIKYVAYQCLSALSYIHDLGLTHRHLSPETILISRSQEIKLYNFGLYYMTDMGRNVSFPIGSPKYTAPEVFLNEQSTPSSLKVDSWSLGMIIAELLLKRSLWAELKLGQCLWKLLSLLHSKNGIFERLALECDRHDTYKKIPQELKEFVAKALEVDPSKRLSALELLDLPIFKEFRAGEFKDQDEFLDVVTRKMDDLYYLWQLAGGDMTGELKKQGLIRSRPPILSIPNLIILLGQIPKLSTEADFHLQDELTNATTKLPLIIRERDTEYQFYRLVLFERLLQAYPVSRSAILREAHKDIPPPFRGQIWAAILGVVGNIQRKYEQIDKETPTHTDRQIEVDIPRCHQYSELLSSGSGHERLQRLLKAWVRNNPQYVYWQGLDSLTAPFLYLNFNNEALAFACLEAFVPKYLHQFFLKDNSAVIQEYLGKFSQIIGFHDPKLANHLRGINFVPELFAIPWFLTMFSHVFPLHKILHLWDKLLLGDSSFPLMVGLAILKQLRDALLTSGFNECILLFSDLPEVDIELCVKDSMDMYTNTPTSITYRKYQFDQSKASHWKEPEPGTEKVPRISIDDFVNYYGNKRDKMIVVDIRNNIQYERGAVKGSINIPFTSVQLSHTSIESLGNQAKVLADPDNNECIVVVIGPHDQNNALQTMMRFIIVGFLIFHGAIAHHEMGPNQCRDEEKKIEIPSENAKKDFARINAADGIENATELVFMSNSNGGVEYFPCPGVMLSKNHVLISSDCDTEANAKIAVGYKADLVKKTEEFINRTVSEIITMENAHMVILKLAEAMPEDHNRKIMQLPTKSCEMGDVYKIKGWSFTPDRVKEDDIFYDTFLMHEEDVSIIDKKDCPHAVENECCIKMKQTEKEFKMMVGSPVIHEDHIIGFAHFDCNTQGAISLVFPWVEEIKKIIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2GZG9</accession>
    <name>A0A8J2GZG9_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Similar to TAF5: Transcription initiation factor TFIID subunit 5 (Homo sapiens)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HICCMSTLAB_LOCUS539</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001114">
        <property type="protein sequence ID" value="CAG5073644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2GZG9"/>
    <dbReference type="OrthoDB" id="10266330at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08044">
        <property type="entry name" value="TAF5_NTD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.500">
        <property type="entry name" value="TFIID subunit TAF5, NTD2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007582">
        <property type="entry name" value="TFIID_NTD2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037264">
        <property type="entry name" value="TFIID_NTD2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19879:SF1">
        <property type="entry name" value="CANNONBALL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19879">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04494">
        <property type="entry name" value="TFIID_NTD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160897">
        <property type="entry name" value="Taf5 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TFIID subunit TAF5 NTD2" evidence="4">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="140"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="165"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAG5073644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="211" mass="24085" checksum="FD562E1B0F4AED50" modified="2022-05-25" version="1">MYLELVYNNHSEQAKQLLEKYGPSLDDHHQTDLKRLSNVTKREQMAGNEFTDTFKSNQFIIRISRDTLSILKRHLQEKKHSVLLNIIQEHLYFDMYEGTARNKQQIEATSGATLGEATRQDNKAKVYYGLLKEPDIQCVAPAEEEEDEANAGGEGDKPKKKKAKKDPLFSKKTKSDPNAPPVGRMFLPNLKDADKLEKVKALREASKRSIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H2A0</accession>
    <name>A0A8J2H2A0_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 4">Proteasome assembly chaperone 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HICCMSTLAB_LOCUS1222</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="4">Chaperone protein which promotes assembly of the 20S proteasome as part of a heterodimer with PSMG1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Forms a heterodimer with PSMG1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the PSMG2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001116">
        <property type="protein sequence ID" value="CAG5075032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H2A0"/>
    <dbReference type="OrthoDB" id="10260712at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000502">
        <property type="term" value="C:proteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043248">
        <property type="term" value="P:proteasome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10900">
        <property type="entry name" value="PAC-like subunit"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019151">
        <property type="entry name" value="Proteasome_assmbl_chaperone_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016562">
        <property type="entry name" value="Proteasome_assmbl_chp_2_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038389">
        <property type="entry name" value="PSMG2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12970">
        <property type="entry name" value="PROTEASOME ASSEMBLY CHAPERONE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12970:SF1">
        <property type="entry name" value="PROTEASOME ASSEMBLY CHAPERONE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09754">
        <property type="entry name" value="PAC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF010044">
        <property type="entry name" value="UCP010044"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159659">
        <property type="entry name" value="Cgl1923-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0647">Proteasome</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="13"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00019186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR010044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAG5075032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="242" mass="26689" checksum="5170FC255BA9374C" modified="2022-05-25" version="1">MIKLTTEINLQDFILFLPAVAVGNVAQLAIDLLITSQNMKKIGYAANSCFIPILGADPYVKDSSDLCTSADFYVQESKKLVALQIRSPAVKNLQGFFKDLGKFVADNKISKVVILTSAWAHTRSDIQIRTEPMRFLASPSCGEIFSGLDFLELETTKDEAGREGFEISGGGFALKLHEFLSNQGIPSVVILRFCSEGDNVPDAVAVLEYLNRWLAFGFDAKKVKFPDSWEFLFGNAAPVDIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H3W7</accession>
    <name>A0A8J2H3W7_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cytoplasmic aconitate hydratase</fullName>
            <ecNumber evidence="3">4.2.1.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Citrate hydro-lyase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">HICCMSTLAB_LOCUS2206</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>citrate = D-threo-isocitrate</text>
            <dbReference type="Rhea" id="RHEA:10336"/>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
            <dbReference type="ChEBI" id="CHEBI:16947"/>
            <dbReference type="EC" id="4.2.1.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the aconitase/IPM isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.3" evidence="3"/>
    <dbReference type="EMBL" id="CAJNRD030001117">
        <property type="protein sequence ID" value="CAG5076508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H3W7"/>
    <dbReference type="OrthoDB" id="2279155at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003994">
        <property type="term" value="F:aconitate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01586">
        <property type="entry name" value="AcnA_IRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.499.10:FF:000002">
        <property type="entry name" value="Aconitate hydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.499.10:FF:000005">
        <property type="entry name" value="cytoplasmic aconitate hydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.499.10">
        <property type="entry name" value="Aconitase, domain 3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.19.10">
        <property type="entry name" value="Aconitase, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015931">
        <property type="entry name" value="Acnase/IPM_dHydase_lsu_aba_1/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001030">
        <property type="entry name" value="Acoase/IPM_deHydtase_lsu_aba"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015928">
        <property type="entry name" value="Aconitase/3IPM_dehydase_swvl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006249">
        <property type="entry name" value="Aconitase/IRP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018136">
        <property type="entry name" value="Aconitase_4Fe-4S_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036008">
        <property type="entry name" value="Aconitase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000573">
        <property type="entry name" value="AconitaseA/IPMdHydase_ssu_swvl"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01341">
        <property type="entry name" value="aconitase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006757">
        <property type="entry name" value="PRK09277.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009520">
        <property type="entry name" value="PRK12881.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11670">
        <property type="entry name" value="ACONITASE/IRON-RESPONSIVE ELEMENT FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00330">
        <property type="entry name" value="Aconitase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00694">
        <property type="entry name" value="Aconitase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00415">
        <property type="entry name" value="ACONITASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53732">
        <property type="entry name" value="Aconitase iron-sulfur domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52016">
        <property type="entry name" value="LeuD/IlvD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00450">
        <property type="entry name" value="ACONITASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01244">
        <property type="entry name" value="ACONITASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 12" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="12" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 12" id="KW-0408">Iron</keyword>
    <keyword evidence="8 12" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="9" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha" evidence="13">
        <location>
            <begin position="63"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="domain" description="Aconitase A/isopropylmalate dehydratase small subunit swivel" evidence="14">
        <location>
            <begin position="725"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="15">
        <location>
            <position position="847"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00029682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU361275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CAG5076508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="847" mass="93571" checksum="B319F11E4B0D3AFE" modified="2022-05-25" version="1" fragment="single">MAVPNPYDNLLKTVVVNSKERSYYDISSFGKKYDRLPFSIRVLLESAVRNCDGFQVKDQDVQKILDWETNQASDDVEVAFKPARVILQDLTGVPAVVDFAAMRDCVKRLDGDPNKINPICPSDLVIDHSIQVDFVRSGDALKKNEDLEFERNKERFLFLKWGAKALKNMLIVPPGSGIVHQVNLEYLARVVFDSDNLLYPDSVVGGIEAEAVMLGQAVSMLLPKVIGYKLVGTLNQYVTSTDLVLTITKNLRQLGVVGKFVEFYGPGVSELSIADRATISNMCPEYGATVGFFPVDQQSLSYLRQTGRSDEHIERIEKYLSAVKMLRDYSNELQDPIFSETVTLDLATVVSSVSGPKRPHDRVSVSDMKQDFNQCLTNKIGFKGYGLSPDKIKTEGKFTFEGQEYSLKHGSVVIAAITSCTNTSNPSVMLGAGLLAKNAVEAGLTVAPYIKTSLSPGSGVVTYYLRESGVIPALTELGFEIVGYGCMTCIGNSGPLEDSIAETIEKNELVCCGVLSGNRNFEGRIHPSTRANYLASPLLVIAYAIAGTVDIDFETEPLGRRADGSGVFLRDIWPTRVEIQAVEQQYVIPAMFKSVYNKIEKGSNRWASLVAPEGQLYPWNEDSTYIKHPPYFENLQKDLPEAKNIHKARVLLNLGDSVTTDHISPAGSIARNSPAARYLAKRGLTPREFNSYGARRGNDAVMVRGTFANIRLVNKFIGKPGPKTLYIPIGKEYGSGSSRDWAAKGPYLLGIRAIIAESYERIHRSNLVGMGIVPLQYLPGQTSETLGLTGFELFDIDIPANCQPHQQITVRTDTGKKFDVIVRFDTEVDLTYFKHGGILNYMIRTMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H4Y9</accession>
    <name>A0A8J2H4Y9_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Putative rRNA methyltransferase</fullName>
            <ecNumber evidence="8">2.1.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">2'-O-ribose RNA methyltransferase SPB1 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HICCMSTLAB_LOCUS404</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Probable methyltransferase involved in the maturation of rRNA and in the biogenesis of ribosomal subunits.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>a ribonucleotide in rRNA + S-adenosyl-L-methionine = a 2'-O-methylribonucleotide in rRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:48628"/>
            <dbReference type="Rhea" id="RHEA-COMP:12164"/>
            <dbReference type="Rhea" id="RHEA-COMP:12165"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:90675"/>
            <dbReference type="ChEBI" id="CHEBI:90676"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
            <location evidence="1 8">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. SPB1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="8"/>
    <dbReference type="EMBL" id="CAJNRD030001114">
        <property type="protein sequence ID" value="CAG5073461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H4Y9"/>
    <dbReference type="OrthoDB" id="1287559at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016435">
        <property type="term" value="F:rRNA (guanine) methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008650">
        <property type="term" value="F:rRNA (uridine-2'-O-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000466">
        <property type="term" value="P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000004">
        <property type="entry name" value="AdoMet-dependent rRNA methyltransferase SPB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01547">
        <property type="entry name" value="RNA_methyltr_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03163">
        <property type="entry name" value="RNA_methyltr_E_SPB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050082">
        <property type="entry name" value="RNA_methyltr_RlmE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002877">
        <property type="entry name" value="RNA_MeTrfase_FtsJ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015507">
        <property type="entry name" value="rRNA-MeTfrase_E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012920">
        <property type="entry name" value="rRNA_MeTfrase_SPB1-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024576">
        <property type="entry name" value="rRNA_MeTfrase_Spb1_DUF3381"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028589">
        <property type="entry name" value="SPB1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10920:SF13">
        <property type="entry name" value="PRE-RRNA 2'-O-RIBOSE RNA METHYLTRANSFERASE FTSJ3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10920">
        <property type="entry name" value="RIBOSOMAL RNA METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11861">
        <property type="entry name" value="DUF3381"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01728">
        <property type="entry name" value="FtsJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07780">
        <property type="entry name" value="Spb1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 8 13" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="3 8" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="6 8" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ribosomal RNA methyltransferase FtsJ" evidence="10">
        <location>
            <begin position="24"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3381" evidence="12">
        <location>
            <begin position="234"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosomal RNA methyltransferase SPB1-like C-terminal" evidence="11">
        <location>
            <begin position="591"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="322"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="432"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="565"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="765"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="704"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="322"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="493"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="572"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="590"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="766"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="786"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="807"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="157"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="56"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="117"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF07780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF11861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAG5073461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="832" mass="96352" checksum="EC474C1819B3C99E" modified="2022-05-25" version="1">MGKKTKIGKHRKDKYYHLAKETGFRSRAAFKLLQLNRKFEFLQKSRVCIDLCAAPGGWMQVARQNMPVSSIVIGVDLFPIKPIPGCISLVEDITTDKCRVAISKEIKTWKADIVLNDGAPNVGKNWLHDAYQQVTLTLSALKLASHFLKPGGWFITKIFRSKDYNALYWILSQLFKKVHATKPQASRLESAEIFVVCQHYIAPDKLDPKFFDPAYVFSDLDITNNKLFILHPEKRKKAKALGYPEDDHTLHRQLPASEYIAHETGIEILENIAEIVIDDPRIAEHPKTTKEILECCKDIKVLNRKDIKLLLSWWKELRKQFHDTSEKADENTEDNKKEDKDKKDEDESDEDKEQMKIDAEIAELKAEEMRNLKKKKKKTQKERQKLNEKLNLKMIHKGDEGPILECEDMFTLKNITTHQLLNQITDQTPDITATSDIDSEEETFLPKKTKYDKDTNQLDSKSLSYVNEISMSESENSDDDDYNVNESGLNLSDSEDDTSLIEDENDINEGSELNNPLITDLEDNKDKSSKKINKAKIWFEKEAFKNLENDSDEEFELDNMMEVYSKEENSKVNKKKTKNQSKKVQKSVDSDSDYDVEEDFIPKSKKMTQNNESKITEKNAKVTKKRKLNEKELALATLFINSKKSRKDLTDAGWNRYSFGNEKHLPDWFVKDEEKNMKKEEPVPKELVDEYKKQLVDINARPIKKVMQAKARKKKRALRKLEKAKKKTEALIDNEDITDREKSHQIKALYKKALKQPKKEVTYVISKKHTAQKRVPRPSGVKGHYKLVDSRMKKDLRAQKAKEKTKGRGKKTRKGTSRGKSKAKFSKKEKSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H6J0</accession>
    <name>A0A8J2H6J0_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Similar to Atoh8: Protein atonal homolog 8 (Mus musculus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HICCMSTLAB_LOCUS2854</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus speckle</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001117">
        <property type="protein sequence ID" value="CAG5078836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H6J0"/>
    <dbReference type="OrthoDB" id="10001938at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070888">
        <property type="term" value="F:E-box binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009653">
        <property type="term" value="P:anatomical structure morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11421">
        <property type="entry name" value="bHLH_TS_ATOH8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.280.10:FF:000052">
        <property type="entry name" value="Protein atonal homolog 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032660">
        <property type="entry name" value="ATOH8_bHLH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050359">
        <property type="entry name" value="bHLH_transcription_factors"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19290">
        <property type="entry name" value="BASIC HELIX-LOOP-HELIX PROTEIN NEUROGENIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19290:SF102">
        <property type="entry name" value="TRANSCRIPTION FACTOR ATOH8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="8">
        <location>
            <begin position="411"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="122"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="180"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="359"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="37"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="122"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="181"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="197"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="383"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAG5078836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="506" mass="57393" checksum="8FC725E8176CD810" modified="2022-05-25" version="1">MIDISLFGEDENLHSPSGSEDSVEVQISPISLRNKRKLAEPKKALKSDPNRPLKKRRLIERSSSPFRPWNSPEKQEEDRWRIEEERRREEEVQRLYEAQIHAQVLARLQIAAKSQELNQDSRFRTANSHQDPISRTATPHPEAGLRADSQSTEDFRAASLQSAISLNKYGLHTEDKIRTAGLSSESRLRTATQHPEAGLREAPQSKEDFRTANLHQEAISRTATPHLDSKFRTEAILQSEINLNKSNLPSEDKIRTTNLQSESRLRTATPYPENNLHTSTFQSEGRFRAATFDLEGNVRTADPHQDSNYRPGALNSDPRFLQEVKIRTDTLQKRSHSLNYRLQDSAHQNEPLALVLREGRVPPHPGVSDLPYEDKRGGKIPSSRMSSTSGAHSEQSGTNHSQRNYKNMTRERRIEANARERTRVHTISAAFNTLRRSIPAYSHNQKLSKLSVLRIACSYIMTLSKIVREGEDSGVEGVNGAELGECVDLVSRTIQTEGKLRKKKDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H6L5</accession>
    <name>A0A8J2H6L5_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Similar to ABCG1: ATP-binding cassette sub-family G member 1 (Homo sapiens)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HICCMSTLAB_LOCUS2899</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001117">
        <property type="protein sequence ID" value="CAG5078998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H6L5"/>
    <dbReference type="OrthoDB" id="66620at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042626">
        <property type="term" value="F:ATPase-coupled transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050352">
        <property type="entry name" value="ABCG_transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48041">
        <property type="entry name" value="ABC TRANSPORTER G FAMILY MEMBER 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48041:SF118">
        <property type="entry name" value="ATP-BINDING CASSETTE TRANSPORTER (ABC TRANSPORTER) FAMILY G MEMBER 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="7">
        <location>
            <begin position="3"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG5078998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="141" mass="15325" checksum="55A4BC372F811870" modified="2022-05-25" version="1">MYKKVNEVAENLGLQECLGTIAANLSGGEKKRLSIGVEIVSNPQVLILDEPTSGLDSASSYQVMSLLRRLSQEGCTIICSIHQPSSQIVTLIDNILVLADGQDLYCGPRVSLVETFEQAGFACPSFYNICEFGCQYLDPCQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H6W1</accession>
    <name>A0A8J2H6W1_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="19">Similar to nrv2: Sodium/potassium-transporting ATPase subunit beta-2 (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">HICCMSTLAB_LOCUS2796</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="17">This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the X(+)/potassium ATPases subunit beta family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001117">
        <property type="protein sequence ID" value="CAG5078634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H6W1"/>
    <dbReference type="OrthoDB" id="5912413at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005890">
        <property type="term" value="C:sodium:potassium-exchanging ATPase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001671">
        <property type="term" value="F:ATPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030007">
        <property type="term" value="P:intracellular potassium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006883">
        <property type="term" value="P:intracellular sodium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990573">
        <property type="term" value="P:potassium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036376">
        <property type="term" value="P:sodium ion export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1660:FF:000004">
        <property type="entry name" value="sodium/potassium-transporting ATPase subunit beta-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1660">
        <property type="entry name" value="Na, k-atpase alpha subunit"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000402">
        <property type="entry name" value="Na/K_ATPase_sub_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038702">
        <property type="entry name" value="Na/K_ATPase_sub_beta_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11523">
        <property type="entry name" value="SODIUM/POTASSIUM-DEPENDENT ATPASE BETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11523:SF46">
        <property type="entry name" value="SODIUM_POTASSIUM-TRANSPORTING ATPASE SUBUNIT BETA-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00287">
        <property type="entry name" value="Na_K-ATPase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00390">
        <property type="entry name" value="ATPASE_NA_K_BETA_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="14" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="15" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="13 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0630">Potassium</keyword>
    <keyword evidence="5" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="11" id="KW-0915">Sodium</keyword>
    <keyword evidence="16" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="6" id="KW-0740">Sodium/potassium transport</keyword>
    <keyword evidence="7 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 18" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="47"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="271"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00025540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="CAG5078634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="541" mass="61855" checksum="F341209D539D6DCD" modified="2022-05-25" version="1">MEDKSKVDQYYTPPPKLGKWEAFSTFLWNSETGQFLGRTGSSWAKILLFYVIFYGVLTGFFGAMLAVFYQTLDHKAPKWQMDKSLIGDNPGLGFRPMPPIFGWQPQFYNDTENLPANMPNDLKARIKGAKMRNPEELQTIWVSCEGENPADIENIGPIQYKPRSGFPGFYFPYTNSPGYLSPLVAVWFESPKRNVLINIECKAWARNIIHDRDKMVAKDSKKDLGAKVESMNPYEKPPEISTSQSVKNFFYNKETGAVMGRTASSWGKVGIFYLIFYGVLAALVSICFWFFFQTLDVRIPKWQLDRSIIGTNPGLGFRPMPPPSNVESTLIWFKGTDPENYKHWVNQLSDFLEDYKKLGSTAGRGASITECDYHKFPSPDQVCAVNVRQWEPCTQENYFGYHKSGPCVFIKLNKIYGWKPEYYTDVQELPDKMPRDLKTLIGNLTARQAKQLNTIWVSCGGENPADEENIGPVKYIPQQGFPGYYYPYENTVGYLSPLVAVHFERPKTGILINVECRAWAKNIKHNRNDKIGSVHFELLID</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H7S3</accession>
    <name>A0A8J2H7S3_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to Uncharacterized protein KIAA0930 homolog (Xenopus laevis)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS3174</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5081030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H7S3"/>
    <dbReference type="OrthoDB" id="1906921at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008083">
        <property type="term" value="F:growth factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.90.10">
        <property type="entry name" value="Cystine-knot cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029034">
        <property type="entry name" value="Cystine-knot_cytokine"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019141">
        <property type="entry name" value="DUF2045"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000072">
        <property type="entry name" value="PDGF/VEGF_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21477:SF13">
        <property type="entry name" value="KIAA0930"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21477">
        <property type="entry name" value="ZGC:172139"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09741">
        <property type="entry name" value="DUF2045"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00341">
        <property type="entry name" value="PDGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57501">
        <property type="entry name" value="Cystine-knot cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50278">
        <property type="entry name" value="PDGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Platelet-derived growth factor (PDGF) family profile" evidence="2">
        <location>
            <begin position="703"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="312"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="361"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="543"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="597"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="648"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="393"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="559"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="597"/>
            <end position="606"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5081030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="851" mass="96755" checksum="4A641C44220A2C46" modified="2022-05-25" version="1">MASSGSSEGVPRPPTMLELLLEEINFQRTKEMRQLLKDDTTYWMDLFVRYFLFQGEHRIDDDDLLFFVRKKHIKTSSRYMPKFETEVEVFRKDSKKLPIGDPDIDWEETVYLNLVVHQFNYTLTLAICTRTSPKELQVLRRHSQKVYASPSRRRMDAKGDLEEMTYPHICFMVDNFDEVFCDILVRDGEMVCVELVASDRKGAIQGVIFLGSIRYDALKKVYDARSSLSTKMAQRMTFGLFSGASSQRIEFVRMKGPQGKGHAEMAVTKPKGSGAETPTSEPGYSVTDALWDADWDDAEEIFMYRHQRRLSDPSSNLNNFVRGGWRTKPDTASTKARSENEGLDSMANGLNEIEAGDVRDAENQASSWGGRVTSPVRQKENRSPRSRRRRSSSSRDRSDSSSKPITKDKSSSANSRENDKRSSPRRSIGTPKRRHRRHHNIEVGSESVVAASTPEHLTDNVMQKLDTGAILVHGKEELPLGYASNNDNRRITSYPMDIERRNNHQDFEGDENFRGASRRHRARRYFSDDEILGAIRKHGLINGEGREEVNGKTNGVKANGDDSLDKEHLENQDDNDQSCLSEPLKDKNANAKITKVLNSSHKQSATLPRRRRRRALSGSVIGNHPLPPHRVTPDGTAIYYWCELPRRPGSQDRVRSAAKKPETNVTIKNDKPSTEKTESKPGREVECRGMTKTLSKMGKEVICKPRKTLVKLTPDPGYIYIPDVILIDQCDGRCGHESQSCMAIETVSTRVLVQRMQIGSLHSPCWELDVDKHTRCKCDCELMATDCNSRQKYDPDDCLCQCTNMDEMYDCSLKEDMYWNHESCRCSCLIEEEICTAGLICGKVLTDNKIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H7Z4</accession>
    <name>A0A8J2H7Z4_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Similar to WDR74: WD repeat-containing protein 74 (Bos taurus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS3719</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5083055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H7Z4"/>
    <dbReference type="OrthoDB" id="18388at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037379">
        <property type="entry name" value="WDR74/Nsa1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16038">
        <property type="entry name" value="NOP SEVEN ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16038:SF4">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 74"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5083055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="210" mass="23705" checksum="F7611D9581CF6071" modified="2022-05-25" version="1">MNFKNDFDMFVGGKSGVFKGVKIDKNKCIAKNIQNLVSITKDHEVTTMSWGDDDDEKDVLIGCGSAENRSVKVYDSQHSAFSTSFSCNVSAGKIRGISRYNDCIITAVESGDINLWRRSESIKVIKTNEDLHAMRHNKFNKNIIATGGKEHPLQLYDLEQDKVTFKEKNVRHDWLEMRVPVWVSDIGFLPDSSKIATCSRYGYVSSLLIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H8M9</accession>
    <name>A0A8J2H8M9_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reactive oxygen species modulator 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Protein MGR2 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HICCMSTLAB_LOCUS4308</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Has antibacterial activity against a variety of bacteria including S.aureus, P.aeruginosa and M.tuberculosis. Acts by inducing bacterial membrane breakage.</text>
    </comment>
    <comment type="function">
        <text evidence="8">Induces production of reactive oxygen species (ROS) which are necessary for cell proliferation. May play a role in inducing oxidative DNA damage and replicative senescence. May play a role in the coordination of mitochondrial morphology and cell proliferation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MGR2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5085214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H8M9"/>
    <dbReference type="OrthoDB" id="5409308at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005744">
        <property type="term" value="C:TIM23 mitochondrial import inner membrane translocase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045039">
        <property type="term" value="P:protein insertion into mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018450">
        <property type="entry name" value="Romo1/Mgr2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28525">
        <property type="entry name" value="REACTIVE OXYGEN SPECIES MODULATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28525:SF1">
        <property type="entry name" value="REACTIVE OXYGEN SPECIES MODULATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10247">
        <property type="entry name" value="Romo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01378">
        <property type="entry name" value="Romo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAG5085214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="78" mass="8186" checksum="E24CF9298E0AD170" modified="2022-05-25" version="1">MPVPVGNYQQGPSCWDRMKMGFGIGFCVGMASGALFGGFSALRFGMRGRELVHSVGKTMIQGGGTFGTFMAIGTGIRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H8P5</accession>
    <name>A0A8J2H8P5_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS4329</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5085278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H8P5"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5085278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="163" mass="19027" checksum="0F9B3C4F908819AA" modified="2022-05-25" version="1">MITWTQKLRRRLEPSANPTQEDTRPRRQPCRLLKRKKNYITQCNDVKQSDIGNTSAITTAIPTRIVLALNGTFPTVDRSSNRPMHSSPTSPDVIMRWLVVYTRYTLQDTRYNSQLTTHNSQLTTGRLRPEARLGIEDRGSRIKMASQATWYKYKYNILKWLIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H963</accession>
    <name>A0A8J2H963_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS3601</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5082584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H963"/>
    <dbReference type="OrthoDB" id="7679028at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5082584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="152" mass="17428" checksum="B6CEEFC14611A97D" modified="2022-05-25" version="1">MILTQRIMVSFVILVIHNGRDYGNGFLDIIRISIGSGIDAPLDKLLIRVTFIMTTLLFFVVTPDIQGQIFSYSTKPERSYPQNLKDLGDFKFNIYYPKPLKDFILDQKLVWNLNKTYLRPFTYHPSTCHDKVLKDSSNACLTSSIEPFSGNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H967</accession>
    <name>A0A8J2H967_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS4381</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5085453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H967"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5085453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="89" mass="10209" checksum="483065777FDDD916" modified="2022-05-25" version="1">MSGQSFGPRCFVFAHTLGASFQMTFAITTRRLDPSVATIVVRNIINRSHRSLINITHWIIGRLISLTSRAVVLHQRRFWIRGPRTTTYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H968</accession>
    <name>A0A8J2H968_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SOSS complex subunit A homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HICCMSTLAB_LOCUS3827</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="2">Component of the integrator complex, a multiprotein complex that terminates RNA polymerase II (Pol II) transcription in the promoter-proximal region of genes. The integrator complex provides a quality checkpoint during transcription elongation by driving premature transcription termination of transcripts that are unfavorably configured for transcriptional elongation: the complex terminates transcription by (1) catalyzing dephosphorylation of the C-terminal domain (CTD) of Pol II subunit Polr2A/Rbp1 and Spt5, and (2) degrading the exiting nascent RNA transcript via endonuclease activity. The integrator complex is also involved in the 3'-end processing of the U7 snRNA, and also the spliceosomal snRNAs U1, U2, U4 and U5.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5083395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H968"/>
    <dbReference type="OrthoDB" id="2021145at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045334">
        <property type="entry name" value="INTS3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019333">
        <property type="entry name" value="INTS3_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13587">
        <property type="entry name" value="INTEGRATOR COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13587:SF7">
        <property type="entry name" value="INTEGRATOR COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10189">
        <property type="entry name" value="Ints3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrator complex subunit 3 N-terminal" evidence="4">
        <location>
            <begin position="60"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="715"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="794"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="831"/>
            <end position="848"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00032741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00054331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF10189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAG5083395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="848" mass="96648" checksum="D5BE2F1743FB4519" modified="2022-05-25" version="1">MEIKTGSSNNWRLFNTSCIENKDELEEKFERCHGVLQGLTAGLSEKEAHDTLNNAVCKDKTHEEVSLGLLVVILTDPQDATKSYRDLTLITRDGLAIVLSHLNQLVLERYLRLNDTTRSQLLWLLRELIRTNIAGVDNLCLSLLRHAAGGDISPRNIYLVEALLDIFQDNRPWVGNFPYLVAFIVYTYLRLIEDHSAPHLQQLRAKEVTFTVTLIREHIVDCLLIGRDLVRLLQNVARLPEFESLWRDLLTNPRSLNPNLTGVLQLLQTRTSRRFLQSRLTPDMERKLVFLTASVRFGNHKRYQDWFQRQYLATPESQSLRCDLIRFIVGVIHPTNELLCSDIIPRWAVIGWLLTTCTSNVAASNAKLALFYDWLFFDPEKDNIMNIEPAILVMNNSMRSHPATMERIVQMILEDDLGVDSITPLANCLSTILASEITSDIFPSNNLNDEALTDSISTPIFVMFRNYFQLCKEEDSRKKFLGHMLAELQNLQPSIGYLLLYFLKVWGREEEKREGLASNITNEVKAAVYKDFSHHRNKKLEACLLDDLKNCHQDNVLLLCYLVPDVFMGFQNIALGNATLLHLVVSTVDSCQLQDLVCQILQGQLKMLEKDSFNGLLMKSLEWETFEQYCFWQLITAHDFPIKYVLPVVPKLQFKNHAEAMTAILPTLELLRQLFTRQNNDGDTFVVAALRYWCRDYEDKLGELLANLLSTRYPATSPNKRKRAGAKQNQQQSGPPTGEQVLGHLDQLRQHCRASSDLQLYQTEGMQKALQQAQAASSDSLRKSYGDLFALAEVNEENEPPPPPPTSSSRKHTASATGSSKTGAGHRKIISTRERTASKRPPPRDHFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H9M6</accession>
    <name>A0A8J2H9M6_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS4932</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5088663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H9M6"/>
    <dbReference type="OrthoDB" id="7677676at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035195777" evidence="1">
        <location>
            <begin position="19"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5088663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="279" mass="31716" checksum="D5150B3E4218803B" modified="2022-05-25" version="1">MLKLQVFVVFLLAVIIEAGPVVYNEPVLLSSLDPQWHLIPVEPKASNEPNLYGAEQEAAEKESFYDQIYGWTLKPILDLTDWMLSPVMSMYEKTMNFMGFGNKSKKMDDGDDAAPRSRRKRGVVGSVANTAVNTVHLPLSFIYDIALAPFRLIRRIFNFITAPFRAVYNKIGSLILPSSFRNNSQSSNVVLALLSNTGSTTTDNEEMWNQMMKNVGKAAKRNAVKMLNKGWDYTKADILPSLDSLIEKYGESDLLPEDFRKMLKNFRRIYQVTHMFNII</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H9T4</accession>
    <name>A0A8J2H9T4_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Similar to l(2)03659: Probable multidrug resistance-associated protein lethal(2)03659 (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HICCMSTLAB_LOCUS3969</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5083926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H9T4"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000163">
        <property type="entry name" value="Multidrug resistance-associated protein member 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF415">
        <property type="entry name" value="FI20190P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="382"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="459"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="529"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="554"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="642"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="61"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="10">
        <location>
            <begin position="386"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="746"/>
            <end position="975"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="989"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAG5083926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="989" mass="113236" checksum="B27E7531EFADE3FC" modified="2022-05-25" version="1" fragment="single">MASAINLNISTEDLKLSIFGNFLLLDETCKSSITLNNLKNSEYKNNRCNNQLNKSSSGVEIELDEVSASWRINHPLQILNSITLKFKSGELCAVVGPAGSGKSSLLNLLLQELPVDAGTVRLFQMKNEVSVDLRTMLGFVQSKPEITISYASQDPLLFSGTIKDNILFGLEYDHARYQEVCFLVKDFKELPNRDMTIVGEGGKSLSIDQKTKVNLARAIYRQADLYLLDDIFHGIDDNDSEFIFNECVLGFLQGKTRILVTDHIDYLKQADTIAVIEKESIKHQGTFVTLKEESFEFNELLHTIQQNKTTNYTKIITTNMNEENENIEIEFNLMKSRHTNQFTCRQEVVKIQVEGKVDDKAISSTNNLKKTSHRHFNSCREISIYLLLLVLIILWQLATITVDQWMAYWTTVESIKTCIQAPKFMCINLQNQLKSILDTNINKNFVNEHKLIVHKNAKYIYTVLIITLIGLFISSIYFSINFCISVGQKLYNLIFCDFLKAKMEFFSSQFSEKTASKLIKDIQIMDNSIIPAVIQTMVIIFQIILTIINIATVFRWILLPFILMAPILFYLTKYFCRTIQSIQELENNTKNPLDLHVRETLHGLTTIRSYSENVLLKLCEKFNQHQEMNAGARYILISIMSAYNLAIELLFCIFISCVYFLLIAKHQDCENNFDFPENTFNESVGFAISQSLILMSLFQYGTQQIVIILSQLTVMRRIIQFIDTPKEGTIETQNPPPANWPSDGQIIWRNIFINNRRYGLSVFQNADLMIEPCWKVGVVEKTNADNTSITSALFRLVDQGMHEEIIIDGLDIKSVGLQDLRSNISIIPKNPFLFTGTLRFNLDPFQQYTDKAIWGVLGEVELNGITLNQWVTDGGRNFSINERKLICLARALLRSNRILVLDQITDGLDLNTKIIIQRVLQSYFKYCTIITITNHLESLISGDLILVMDNGRLLEFGSPYELLIMRINSHFGQMIKKYNQTMVECIIQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HAS8</accession>
    <name>A0A8J2HAS8_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS5347</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5089714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HAS8"/>
    <dbReference type="OrthoDB" id="10255091at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5089714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="172" mass="18754" checksum="FEE4A109F70C6909" modified="2022-05-25" version="1">MARPSSTAATIDEKLSSANTISDADFATAVPEPMAIPISAFFKAGASFTPSPKAPHGRTISPWSKLPSVEQWASHRIHDQIKTPIRLQMASAVALLSPVMTMTRIPAARQRTIESKTSLRGGSNIPTTPMKVRSFSYMKNLFESPRSISSGFIGWSAVARARQRRVSRPVPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HAT1</accession>
    <name>A0A8J2HAT1_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS5965</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5092182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HAT1"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5092182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="81" mass="9268" checksum="959EA299C45F9B2F" modified="2022-05-25" version="1">MVKSINCVGERKISRLLNQIGKIRRYKMDPELNPTTAGNSLMYQAIEDELLKNFKFLLENGMDVNERIITTGEFNGFTALN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HBK9</accession>
    <name>A0A8J2HBK9_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS5011</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5088873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HBK9"/>
    <dbReference type="OrthoDB" id="7689088at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="605"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="146"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="458"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="610"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="658"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="677"/>
            <end position="695"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5088873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="710" mass="81969" checksum="C4E0B8C8D9717257" modified="2022-05-25" version="1">MDQESNKCDKTSEVTKQPPERVRCTTSQDTVASYAEMRKSSQPIDTIDTIWNLSSSNTNNLLSNDAQDFLRYQEGQQKLKHIYKVYTSLHRKMTASKKEFAELKTALEKETTLNKTLRNKSASALQLTASFNQHINYMNDTLICNKESAKNLEDMYENEIVKLLNDKENLSKKFDELNQFFQSEDEKYNEEVKKIQLEIAKMKTKNAASEDKLIKLKIETNKAKEKLAMSKQFTANQKIIEDELKNRVEELKHSLNEQEKKRMDMMNNFPDTDKIKETKQYFAEKLSLAEGELNKAKSLLNSVREEYEEDLKKYEEQEKLCEDLDKNVEETSSQVNQIKSQTDEANLKLKQVNEENLNTKKKIDEKTHDLSLIKDKIASETLERNNLADQVNSLKEAMEKKKEENDGLKQKLEEKKAQLIEVEQSKTNTNKDLKEFQLIEESKVVEFQKKLDIQIERKEKALIENEELKVDKQKMERDYEKSLKELDDRYNAGVANLEKQMALNNKLAAELSETQNSILSRQDDFTSLEAQIEKDKKNLESKLKKAEEILSKKNESEKQLMEQKHQLEVKIKELENECKQLEEMYGIDGKLSKSLSNLELKVQTPEKPIFSSQSSAESTKELQNSTNLKQLPIPGISSQSSRKKSSSFLLSSDSDDDDIKKKETHDKVDGLLKALRISQTPPSSPEQSLKVTPSPGTAKRSLFSKKNETS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HC26</accession>
    <name>A0A8J2HC26_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Similar to TTC37: Tetratricopeptide repeat protein 37 (Homo sapiens)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HICCMSTLAB_LOCUS6388</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5092823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HC26"/>
    <dbReference type="OrthoDB" id="421075at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055087">
        <property type="term" value="C:Ski complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006401">
        <property type="term" value="P:RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039226">
        <property type="entry name" value="Ski3/TTC37"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15704">
        <property type="entry name" value="SUPERKILLER 3 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15704:SF7">
        <property type="entry name" value="SUPERKILLER COMPLEX PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13432">
        <property type="entry name" value="TPR_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13431">
        <property type="entry name" value="TPR_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13176">
        <property type="entry name" value="TPR_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="444"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="548"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="582"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="768"/>
            <end position="801"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG5092823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="1234" mass="140660" checksum="8632C419CABE9E51" modified="2022-05-25" version="1">MSKEAKIALKEIRSCLDEHQYVEAMKKCQKLLKTDKKNYMALILLGAAMKDIDQYKSQAPLAYRKAIDLQPDNPLAWRGLVKFYEGQPGNVETWRELVPAYCKLLKLDSDVQKNLNYLDQLSRLSIILNDNGIFDEVIVLILELKEDKDKNELYKIDELLISMINGFTNALPKYHELYKNVLLSSLDKDISSKHLEYYKNYLKLLFSEKNYSGLFSAATQMNLKYPREMYPLEWICRVYAEQIVLEDYETVQDIAIDLYYQSLFDLNSDSYLAIFAKAMHYWLKDNLIESRDLLYQAIALHPKLLFAWIALSNVNSKLHCWAEAENAAEKSLQLINKNSKIMIEKLNLQLIESLARSESKKKWEQAAEKCKTLLENNNSLKKLKLLYARVQILQDIPEAFTLLKELENDPETHQEALVIRALYLKNRESFEEAIDVLGAILDTSEAWLILGTIYWKMSNYSHSLMAFLKGIHADPNDWECLVYLGHYYREHGNDLEKSRKCYQKALRINPNSEEAGSGLSTAYRLLKNTEANMQMLQRVTTEEGGGPKWAWLQLGLQQLDQGKIEQAIKSLRYVIRADPNDNHCWESLADAYWARGAHTSALKSYQRALDLSPGSLYPMIQLANIKLVLGRHDEAKEAFIQVLSQEQRYILALKGLAETCLGLAKESASKQLLGRARRNCQQAIDCITDAIIENTCCYLSQLIHDSTVNRKVTAEKSLEAAKQAVRLCPTTWVHWNILGVICMMPEIKNYALAQHSWVMAIDREPNNGVAWTNLGTLYLHLGETFKANKAFSRAQRADPEYSNSWIGQGIIAESVDNKEAMDLFRHAIQLGYHPQAAVGYSHWVLMTILNPDAKKDALYHYMIVNMHAIPVAIDAMTWYTEREPGVIYGRNALGLLLEREKLYKLAAHEYSVGLKLGKEDSQEDHVRVNLARVLVQMGKFDEAIEVCQRIKIASFNSHCQLALALFKAARYEESYAAYEAALNWLADDGSDKAHVLCAMASMAYMFQEVDDVKTLLFQCIEIQPPTVAGLLAAAALGLLHDDLNLTSLVLKELEIYKDDPKYRHHVARLSAYSCLMHHDITGAIRIISKSIHRRPDDVGSWISLVRLLLETNSSDFGYCAQKALYLGRKNSTVAVAQVACVSSLGQLIDINNDKKQCGLRSVQKTIFSFPGIAESWANLIVATLPRCEKSDSVPNFKWLLSLVSIIREKWNCSKPMNEWLQTNQEKILEISTKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HC39</accession>
    <name>A0A8J2HC39_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Similar to CG4622: Zinc finger CCHC domain-containing protein 8 homolog (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HICCMSTLAB_LOCUS5190</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5089317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HC39"/>
    <dbReference type="OrthoDB" id="8026949at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052115">
        <property type="entry name" value="NEXT_complex_subunit_ZCCHC8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006568">
        <property type="entry name" value="PSP_pro-rich"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13316:SF0">
        <property type="entry name" value="ZINC FINGER CCHC DOMAIN-CONTAINING PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13316">
        <property type="entry name" value="ZINC FINGER, CCHC DOMAIN CONTAINING 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04046">
        <property type="entry name" value="PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00581">
        <property type="entry name" value="PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PSP proline-rich" evidence="7">
        <location>
            <begin position="224"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="26"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="438"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="32"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="440"/>
            <end position="460"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG5089317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="555" mass="61998" checksum="521BF266EA107F47" modified="2022-05-25" version="1">MSCNGDSQEADDSVVCLDTSQDLSVCENDADVTDHNDLDDKSSEGKTLPPGAAPEGFIVIDEAVDDLEEKNEDDEPVIKVIFRDKNVAREYRRRVKEYLQRLVRVDLPEDDSSDLVLAIWDKNSEKTERKDLSSLFTIDSKPSREDFCKVPTYGKKFDRVLKESSGNSDEEKESIGPKLTCFNCLENHNLRDCPKPRNFNEINKNRKEFSSRSNSKNSRYHVDEVKFVPGVLSNELRKALGLSHNELPKHIFKMRTLGYPPGWLEEAKQEHSGLNLYNSDGRRVLDPAEEVGEIFSPEDNIKFDIKKIHDYPGYNVPPAPGVRDAYWNPEMQAMHSKEAMLMMLAHRKAEQGYKKKKLETTTTTTSQPSPDADVELIEMDCEPSEDSVVELVPINGEDSEHPLPPGCEELPATPKLDLSCDSPSLADLERRKKLLLQELNDSPMSSPGTPKSSLNNSTVETPKSAAKCLNISPETPTQSSNETTPKVGAVKSVELGTPLLKSTSKFTRLPSSGNFSKDICDVINFENLPGATGKYEKMSGIIQKIRTTLSNQDLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HCG2</accession>
    <name>A0A8J2HCG2_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HICCMSTLAB_LOCUS4905</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5088595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HCG2"/>
    <dbReference type="OrthoDB" id="8190074at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049680">
        <property type="entry name" value="FLVCR1-2_SLC49-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10924">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10924:SF27">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 49 MEMBER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="36"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="65"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="109"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAG5088595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="224" mass="23700" checksum="C486D0D7C709EC00" modified="2022-05-25" version="1">MPTWLAADEIPVAVVRSPVGNQTADTSAVADLSTPLKIAAILSTLATFIRCLSIQATVFTTTAHIAAIVNGFSGVIIGPATALVSAVWFPTGERTTATGISSAASQVGMAISYVLGPGLVGISHVNSTISLRSQKSANIYRMFPLPGMSFDFTGKNRSAIPAETSVYQTSLQIQIMSLMRIEFVVQCLVLIGILTWFPKQSQISNSNIQVSTLGLLESLIKLIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HCT9</accession>
    <name>A0A8J2HCT9_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS5676</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5090554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HCT9"/>
    <dbReference type="OrthoDB" id="8195018at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47501:SF5">
        <property type="entry name" value="HAT C-TERMINAL DIMERISATION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47501">
        <property type="entry name" value="TRANSPOSASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5090554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="575" mass="65860" checksum="8D4DA37E35720E92" modified="2022-05-25" version="1">MDEHEGYFMLNRPLLNPTPFDLGAIIVVYISKRTLIQNKTTSHIYNVKTQSVIEIRTTCVVMSDDSSVSSSQDLVLAHDEDMNEQEPETELGRVQNVQEIKNQLIAECNKRPYLDGTFFIPDLEKSSIDGTVVGICQICKKDHNKNHSIRGSLKALSNYISHIKTVHGNKKKDYDKYVTEKKNQKITEEKDNTKTMCKFSQAVFEANIINWILETLVPFNAVESPSFRKIFDDMHIKNRGMPLRHLSARTVARKIEDTFKHNMLSLKNMIKSAQYVCITADTWSSKSRRFIGMTVHWVSELEVPQCEIDEDDCIEAEDFESRPDNCPVETLAHHIRCASHILNLVATTDVMKIIAATESLQSNYTTLLDQSLKRPVATRWNSLYDSLMQIFGLQEKILSNMEALNPDKTLDRDDFRFMEEFLHCHRPIAQALDILQGDKVASYGFLLPTLISTKNRLIECQKLNFQYCDDLVNGLITALETRFKNMFEVVEEGRNAAIAAATHPQFKLEWLKSLPDHAKINVLEALKEAITSIVNNDNQRHQEQANDQVDNSFFLFTPHPDHTTNDETVLGTWDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HCZ9</accession>
    <name>A0A8J2HCZ9_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS5797</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5090919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HCZ9"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5090919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="97" mass="11152" checksum="A7C28F0F973EEA8C" modified="2022-05-25" version="1">MTAGMLSSAQSPASLRLRLWCKSCYWYAPIVFNNLLWMWPMSADTCVQTAWPLLNTNRPLTHISNIMSNCQRPSLLSATRLLCHYFSPGLCLLRLFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HD07</accession>
    <name>A0A8J2HD07_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS7164</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5093838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HD07"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5093838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="124" mass="14522" checksum="A834FAA22ADFF7E0" modified="2022-05-25" version="1">MPRKPINNRFNKQNKHFFNHDDRTARMDDDHPMEFGGVKPRVSFKNPRFGRDRVRHVNSVTKDQIAEAMSSSTSVRQVMFKPRSRGKGGRLSPMVNRGPRLNIKSRVNLNGEAQWYKIMVDLLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HD72</accession>
    <name>A0A8J2HD72_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Voltage-dependent L-type calcium channel subunit alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">HICCMSTLAB_LOCUS7071</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="17">Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 17">Membrane</location>
            <topology evidence="1 17">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="17">Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5093745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="431720at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016324">
        <property type="term" value="C:apical plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016323">
        <property type="term" value="C:basolateral plasma membrane"/>
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        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005891">
        <property type="term" value="C:voltage-gated calcium channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008331">
        <property type="term" value="F:high voltage-gated calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098703">
        <property type="term" value="P:calcium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019722">
        <property type="term" value="P:calcium-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009582">
        <property type="term" value="P:detection of abiotic stimulus"/>
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        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009581">
        <property type="term" value="P:detection of external stimulus"/>
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        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050906">
        <property type="term" value="P:detection of stimulus involved in sensory perception"/>
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        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042045">
        <property type="term" value="P:epithelial fluid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016322">
        <property type="term" value="P:neuron remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000007">
        <property type="entry name" value="Voltage-dependent L-type calcium channel subunit alpha"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Voltage-gated potassium channels. Chain C"/>
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        <property type="entry name" value="GPHH_dom"/>
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        <property type="entry name" value="VDCC_a1su_IQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050599">
        <property type="entry name" value="VDCC_alpha-1_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005446">
        <property type="entry name" value="VDCC_L_a1su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002077">
        <property type="entry name" value="VDCCAlpha1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027359">
        <property type="entry name" value="Volt_channel_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45628">
        <property type="entry name" value="VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE A SUBUNIT ALPHA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45628:SF1">
        <property type="entry name" value="VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE D SUBUNIT ALPHA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08763">
        <property type="entry name" value="Ca_chan_IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GPHH"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00167">
        <property type="entry name" value="CACHANNEL"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01630">
        <property type="entry name" value="LVDCCALPHA1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01062">
        <property type="entry name" value="Ca_chan_IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="4"/>
    </dbReference>
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        <property type="entry name" value="EF_HAND_2"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 16 17" id="KW-0106">Calcium</keyword>
    <keyword evidence="5 17" id="KW-0107">Calcium channel</keyword>
    <keyword evidence="4 17" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="15" id="KW-0407">Ion channel</keyword>
    <keyword evidence="12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="13 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 19" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <keyword evidence="10 17" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="89"/>
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    <feature type="transmembrane region" description="Helical" evidence="19">
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        </source>
    </evidence>
    <sequence length="1807" mass="204164" checksum="212FC8B96068F51D" modified="2022-05-25" version="1">MSTGDGVASSGPGVDSGARVTSLSYPATQPSGTASVTAPQDNMGSTKAVAPAGGAAPGAGGTSITPAAPKRPARRGGKPPPDRPVRAPFEWLILITIFANCVALAVYTPYPCGDSNSTNMFLEKVEYVFLVIFTAECVMKIIAYGFALHQGSYLRNGWNMLDFTIVVIGMISTVLQHLMKEGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSILRAMIPLLHIALLVLFVIIIYAIIGLELFSGKMHKTCRSNITDKIMENPHPCGESGFQCSSLGPEYFCSRQYWEGPNDGITNFDNFGLAMLTVFQCITLEGWTDVLYDIEDAMGSTWQWLYFISMVILGAFFVMNLILGVLSGEFSKEREKAKSRGDFQKLREKQQIEDDLRGYLDWITQAEDIEPEADEMPQTQDGKQKQQNEMESTDRLEGDEEGVQQESVWKRKRRDFDRVNRRMRRACRKAVKSQVFYWLIIVLVFLNTGVLATEHYRQPDWLDQFQEVTNMFFIGLFSMEMMLKMYSLGFQGYFVSLFNRFDCFVVVGSISEMVLTRTEVMPPLGVSVLRCVRLLRVFKVTKYWRSLSNLVASLLNSIQSIASLLLLLFLFIVIFALLGMQVFGGKFNYDDLQDKPRSNFDSFWQSLLTVFQILTGEDWNAVMYVGIMAYGGVANILLNVFLAIAVDNLADAESLTAIEKEAEEEAEKNKSRSGSLAHDELIGPDDGGDLTGGEEEEEGGGTDLEHDPNETMDDYEAALDTEGSKDEEDSDRRGKIRITIESDDENFEHGEEEEEEEEEEDDHTEMDDGGMGGEEISARPRRMSEYKMTNEKPPIPEGSSFFLFSQKSRFRIFCHWFCNHSWFGNVILMCILISSGMLAAEDPLNAQSDRNNILNYFDYFFTSVFTFEICLKMISYGFVLHDGAFCRSAFNLLDLLVVCVSLISMAWRSGAISFIKILRVLRVLRPLRAINRAKGLKGKFFSCNDESKITEEECQGTYLVFDEGNINQPVMKERAWKRNRFHFDDVAKAMLTLFTVSTFEGWPSLLYVSIDSNRENYGPIHNYRPIVAAYYIIYIIIIAFFMVNIFVGFVIVTFQNEGEQEYKNCELDKNQRNCIEFALKAKPVRRYIPKHRIQYKVWWFVTSQPFEYTIFTLIIINTITLAMKFYNQPDPYTHALDVLNMIFTAVFALEFVFKLAAFRFKNYFGDAWNVFDFIIVLGSFIDIVYSEVNPGSNIISINFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFGKIALDNETTIYRNNNFQTFPQAVLILFRSATGESWQNIMLDCSNRPGEVKCDPKSDERTSNGCGNDIAFPYFISFYVLCSFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFIRLWSEYDPDAKGRIKHLDVVQLLRKISPPLGFGKLCPHRVACKRLVSMNMPLNSDGTVLFNATLFAVVRTSLRIKTEGNIDEANASLRAVIKKIWKRTNPKLLDQVVPPPGVDDEVTVGKFYATFLIQDYFRRFKKRKEQEMKEGDKDCHNTATLQAGLRTLHEAGPELKRAISGNLEELLDDNPEPTHRRNHSLFGSVWSSMRRGHHSFRAKSLKTNSNNAPKISPTNSIDFVPYASLQRAGGADGNQITARSHQVVPNVASVISDSGNTQAAPEPRIVGFEENIPMRPLAMFSNTGMQPANFQNPYKVLDLEDGIEHQLTPPTPPPRRNLPSSGATISFATSTETKGDSSTTTTSQTISPSPSPSPITWNNESNGGVGSERLSHSLPGSPADRKPNFEIHIPRNARGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HDE2</accession>
    <name>A0A8J2HDE2_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Similar to Sec63: Translocation protein SEC63 homolog (Mus musculus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HICCMSTLAB_LOCUS5302</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5089606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HDE2"/>
    <dbReference type="OrthoDB" id="1734229at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031207">
        <property type="term" value="C:Sec62/Sec63 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006620">
        <property type="term" value="P:post-translational protein targeting to endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006614">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.110:FF:000063">
        <property type="entry name" value="Translocation protein SEC63"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3380.10">
        <property type="entry name" value="Sec63 N-terminal domain-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004179">
        <property type="entry name" value="Sec63-dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24075">
        <property type="entry name" value="SEC63 DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24075:SF0">
        <property type="entry name" value="TRANSLOCATION PROTEIN SEC63 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02889">
        <property type="entry name" value="Sec63"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00973">
        <property type="entry name" value="Sec63"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158702">
        <property type="entry name" value="Sec63 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="45"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="162"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="11">
        <location>
            <begin position="75"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="459"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="692"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="463"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="484"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="513"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="551"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="565"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="700"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="719"/>
            <end position="728"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAG5089606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="728" mass="84327" checksum="C75111C1EA44092B" modified="2022-05-25" version="1">MGGQKFQYDESDAEQLSRECHCPKCKKKKEILSSDDRWKATRARLLKLFIILCWIALAFLAYKVSQYDAEMANFDPYEILGVSSGASEREIKRAYRKLSLILHPDKETGDEKAFMKLTKAYQALTDDEARKNWEKYGNPDGPGAMSFGIALPSWIVEKKNSVWVLGLYAMVFMVALPTVVGMWWYKSIRYTGDQILLETTKIYYAFFNSQRLTTLKRVIMILGASSEFSKDSNPEIVIRQSDNEEVPSLMKKIQNLGEKNKEFPLCRNYSLKARAIIYAHLSRIPLNPETLEKDRQYIIKKCPYLIQEMIMCVNQLIFLAYSGRIACLPTIETIENCMKLSPMIVQGFWEFANPLLQLPHIEEEHLKHFSGKKRKIKTLQQLAQLKGDERRQILRNFTDEQYEDVMRVLGNMPYVDFKVQSEVIDDDNPTVYTAEAVVTVTVTLYRKDMRHLFGDESVKEKTVEDDEEKDSNNEEAEPAAKSALWRKQKKGAKKTGKKKQQRVAKKTPTTKSSKSEKPEKSPNSKETSESEKNQNENQKVEKSDVARESGSESDAESEKSEEETESKAEEKKESFEDEDDDEWEKFQQRMNKREKVLEGRSNLSHEVHCPMFPDVKQEYWWVYICDRKSHTLITTPVHVTSLVDKEEVQLRFTAPSWPRVYTFSVCLRSDSYLGFYQTQDIKLDVKEAPAVPTQHPQWDISDEETAEEVDIGDEHSEYTTDEDVSDNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HDT8</accession>
    <name>A0A8J2HDT8_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Similar to Tim14: Mitochondrial import inner membrane translocase subunit TIM14 (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HICCMSTLAB_LOCUS7726</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Probable component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. May act as a co-chaperone that stimulate the ATP-dependent activity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the TIM14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5095473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HDT8"/>
    <dbReference type="OrthoDB" id="240298at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001405">
        <property type="term" value="C:PAM complex, Tim23 associated import motor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001671">
        <property type="term" value="F:ATPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.110:FF:000001">
        <property type="entry name" value="Import inner membrane translocase subunit tim14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12763">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12763:SF28">
        <property type="entry name" value="GEO10507P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="J" evidence="9">
        <location>
            <begin position="41"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00054366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAG5095473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="92" mass="10231" checksum="CF52C192EA7C94F9" modified="2022-05-25" version="1">MPTLSKKMAEAYKVLPKLDAKSLANSKYYKGGFEPTMTKREASLILGVSPTASKSKIKERYKKLIVLNHPDCQGSPYLASKISQAKDLLEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HDY4</accession>
    <name>A0A8J2HDY4_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to Neurl2: Neuralized-like protein 2 (Mus musculus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS8158</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5096334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HDY4"/>
    <dbReference type="OrthoDB" id="10059069at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03717">
        <property type="entry name" value="SOCS_SOCS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12887">
        <property type="entry name" value="SPRY_NHR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.920:FF:000074">
        <property type="entry name" value="Neuralized protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.750.20">
        <property type="entry name" value="SOCS box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037962">
        <property type="entry name" value="Neuralized"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006573">
        <property type="entry name" value="NHR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001496">
        <property type="entry name" value="SOCS_box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036036">
        <property type="entry name" value="SOCS_box-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12429">
        <property type="entry name" value="NEURALIZED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12429:SF8">
        <property type="entry name" value="NEURALIZED-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07177">
        <property type="entry name" value="Neuralized"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07525">
        <property type="entry name" value="SOCS_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00588">
        <property type="entry name" value="NEUZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00969">
        <property type="entry name" value="SOCS_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158235">
        <property type="entry name" value="SOCS box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51065">
        <property type="entry name" value="NHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50225">
        <property type="entry name" value="SOCS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NHR" evidence="2">
        <location>
            <begin position="9"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="SOCS box" evidence="1">
        <location>
            <begin position="226"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5096334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="260" mass="29093" checksum="D9C2ABC4DD22F5FB" modified="2022-05-25" version="1">MSEKSRKIVTRFHPSHGENIILCDDNTVAYRKQSFANALTFSEKPLQPGEIFLLEIEKYERGWSGHMRLGLTQIDPVTADKKGLPQYALPNLVNMGSSWVFAITQSHNIYFSVSEGESNPHHEKKLITDGITVQTSRGIIPYTALKPNTVGSSQNILPTETGSRIGVMYVPQRGTDLAEMHFIINGVDQGICGKDIPYKEKPIHAVVDVYGTTKQVRIVQLYAVSTLQSACRDAILQYTKENAVDLLPLPQMLKDFLLYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HDZ2</accession>
    <name>A0A8J2HDZ2_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 15">Histone H2A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">HICCMSTLAB_LOCUS6474</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5 15">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 15">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 15">Belongs to the histone H2A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5092955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HDZ2"/>
    <dbReference type="OrthoDB" id="7682878at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00074">
        <property type="entry name" value="HFD_H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000173">
        <property type="entry name" value="Histone H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002119">
        <property type="entry name" value="Histone_H2A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032454">
        <property type="entry name" value="Histone_H2A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032458">
        <property type="entry name" value="Histone_H2A_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23430">
        <property type="entry name" value="HISTONE H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16211">
        <property type="entry name" value="Histone_H2A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00620">
        <property type="entry name" value="HISTONEH2A"/>
    </dbReference>
    <dbReference type="SMART" id="SM00414">
        <property type="entry name" value="H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00046">
        <property type="entry name" value="HISTONE_H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0007">Acetylation</keyword>
    <keyword evidence="7 15" id="KW-0158">Chromosome</keyword>
    <keyword evidence="12 15" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="8" id="KW-0488">Methylation</keyword>
    <keyword evidence="14 15" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="13 15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-0675">Receptor</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="17">
        <location>
            <begin position="11"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="Histone H2A C-terminal" evidence="18">
        <location>
            <begin position="91"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="16">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00017642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU003767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF16211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="CAG5092955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="125" mass="13446" checksum="2E02AC02CAEB577D" modified="2022-05-25" version="1">MSGRGKGGKVKGKSKTRSSRAGLQFPVGRIHRMLRKGNYAERVGAGAPVYLAAVMEYLAAEVLELAGNAARDNKKTRIIPRHLQLAIRNDEELNKLLSGVTIAQGGVLPNIQAVLLPKKTEKSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HEV9</accession>
    <name>A0A8J2HEV9_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nucleoprotein TPR</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HICCMSTLAB_LOCUS8100</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TPR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5096219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="343070at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034399">
        <property type="term" value="C:nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901673">
        <property type="term" value="P:regulation of mitotic spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057974">
        <property type="entry name" value="NUA/TPR/MLP1-2-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012929">
        <property type="entry name" value="Nucleoprot-TPR/MLP1-2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057577">
        <property type="entry name" value="Nucleoprot-TPR/MLP1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18898:SF2">
        <property type="entry name" value="NUCLEOPROTEIN TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18898">
        <property type="entry name" value="NUCLEOPROTEIN TPR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25481">
        <property type="entry name" value="Nucleoprot-TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25785">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07926">
        <property type="entry name" value="TPR_MLP1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nucleoprotein TPR/MPL1" evidence="9">
        <location>
            <begin position="178"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="NUA/TPR/MLP1-2-like" evidence="10">
        <location>
            <begin position="477"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleoprotein TPR/MLP1-2" evidence="8">
        <location>
            <begin position="1042"/>
            <end position="1169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="891"/>
            <end position="916"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1500"/>
            <end position="1535"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1722"/>
            <end position="2132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="2158"/>
            <end position="2392"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="47"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="240"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="300"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="406"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="548"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="1233"/>
            <end position="1267"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="1295"/>
            <end position="1364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="891"/>
            <end position="907"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1520"/>
            <end position="1535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1727"/>
            <end position="1746"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1747"/>
            <end position="1778"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1792"/>
            <end position="1828"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1839"/>
            <end position="1872"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1913"/>
            <end position="1934"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="1964"/>
            <end position="2013"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="2024"/>
            <end position="2039"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="2040"/>
            <end position="2059"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="2122"/>
            <end position="2132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="2239"/>
            <end position="2256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="2269"/>
            <end position="2288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="2304"/>
            <end position="2320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="2346"/>
            <end position="2357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="2374"/>
            <end position="2383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF07926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF25481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF25785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAG5096219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="2392" mass="269517" checksum="F28D924A2347933F" modified="2022-05-25" version="1">MEQSEDSDCDVLKKILTEDELTQVSDTVANKLRKYFNEHFEEYITAKAVFQHSKQSLEKKLEKLQKDFKERELDLEEHKGKLELTENHVNELQSKLDEAKNEIYKLQENVKRLQKETSEFRRQRDEAVDERNTLQMQVERRDHEVERLHTEVTSLSSQLQAAVTAKCQAIAEAEEIRSREMNLEYKEKRLDQERTLTAQQISALEIELSKRSMELQATRAEASSRALLTDTRLAQRDEELRICNETLTQLREANSNLQRRCDELNQKVEDQRSHELSMHSSYREEIGAQTRLADLYKGMADEANSKAEEFTNAVKELQDLLEQATEQYGALETECGQQKLNYEELMSQKDEKIAEMTKELEQANELLKSIKQERLDQAVEQLAPTAATTSRILKKGSSLTQIYTSLVDTVNELTLEREENERLKSQMDVILRELEERAPILQQQREEYSAALSNVATLTNQLDELLAQNNQMQESHDEAKRIAKHLTRENQKLKTELSDLARQVCFLLKEVQESRTGNTVPMNMDSSMDADLASSDLISKKLVTFKDIEELQETNQKLLAVVRTLSSRQEEIERATDDVASGEVKEKLDRYAEQIAEMQASQERQTKMVESLMRQKDMYKSMYQQALNKTGKEIDNEEEEPMEQEEKNTCEGEFADKNNKIVEENKNKIKELESKLAETEIKLKQTSDEYEIYKKEKAAHERMLGEEIERLRKEAEINSTRCCRLKVQLDSSQERFNLLQANVSTYKSQIKSLEERCANYSTTIAKHEQSIIMLKDDAMSSQTRLSRAEVQLETVKQERQLLRDSESRLLKEREMLHRERQTNALLKADVESIKASLERVQAEGQLRTEMRLDDSIRECAALRRRLQEEQDRFRELTSHLEKQLATAQERLAEEQSQGERLRSDLETARTAQTTAEKRADELEAKLRETITQSRAKPITGDENLAKRLQELEMQLASANAEIRSLTEQLKTSRQQNQQYGDIADSTEAQLKDMTTQYEKQKRELETALEVSRNAVLVLEKKVANLESELTQAQSGQQVTDAELKEKLAVAEAKLEELDEVKGELELMKSDLLSASQAAKEAEEKYAREMQLHSTDLQALAKLRADSANVSKTIDELTRAKNVAVEALEAERLACHEREQKLQNDIEEMQKRIEDLDAQNSLLHNQVQELSDRTAIMQSNRSSLGGQESMDTSLDSSAMNRSLTGVEEDSKSAEQLLRVMKYLRREKDLAMTKLDVLKAENFRLKSQAEVAEKRLKESEMLLSNQREQSEIEVVTTSKHADLLRKVETLNAIADSNRILREERDSLLAKVTELGNQVATLSEEVVPLREKARDLAGKNEAMIQENSSLKNEATRWRQRANTLVERANKASPEDWRRLQTERENLSKLLTSERETHAKRMEEFNALKIEKTKLEEKIAQLQKQIQSQSEQLLKVTEEARQLGQDYSQAIEDSATFKKDLDQLQKELGDKEAVLVDVKNKEIQIRKIAKKYKTQYEELAKTMEEEKTKADENQAAASGEVSVSEERENQLREEGREELRRQNQELTAKIEELTQQITAVQAEAESLKAEIEAMNKASFDKEERTKQLLKNARTRIVMLTDSNKKCEKELNELKMKCESASSDSDPNEHDARLAALKSQLEGRITRLEHEKAEANSEKETLLQRVGQLQRQLAAGVSGVNVTEPPTANIKPMSARAETPLASIRPMSVVVQSRTAAVLPTTANNPVLVAPQQQQQVVHTTETSSPTSSHTDYQPASTSSSVQQPSNLRQLAVQPQLSESAESTQREEPENIENISQQQPQQQAQQQQPCQAQQPQSQAQQPQDQQQQQQQPQTVALVSPRVEQQQQQQQSQQTSSEQQQTIASSSTPSVSTSQASSGHKRPRGLDTCASGSGVVEGTEHSRSEQSPSPKVKRIRTQELASTATTSGSDVEYQVPTSSQRDQDEEGEEGCIVIVDCDEGEGGSHHQAQEEEEFDNDPYEEMEEEEEEEDEDEEEEEEMPYGVEAEVEGDNNEVEIILEDDSRNVEVPRQAQPTIPTSQPPQQQSEAISSAGPTGEPSTFVSRSSRGIAPMPRQQQHFLLPQQGYEDGGDDSIVPSTPTLFVPRRGDGFGEAVSSPQVPQGRFTFGDSAPSSTPTLATPTAVNVRTMFAPSGSGVAQVVQEGMDDTRMDLTQLEDGGTGRSVPTTPLQVSPAAELPPSTSGQSEEQEAPVSGTPVTAPSDVMETTPVPSIRVTDQESEQMEAVPGSSTATTNDGVSSESDQQAAEIAASATVGNVDDDSIDVPADEEDTEEEGREAEASPSINTRQRSIAAAAAASGTPASGTADARGSPARRSNRTYRTGRAGRPTPIIWDNSQGAIGQSNRGHPGGIRGVNNEVARGRGSRGRRSMRPTKYGYPRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HF45</accession>
    <name>A0A8J2HF45_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Similar to Actbeta: Inhibin beta chain (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HICCMSTLAB_LOCUS6419</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the TGF-beta family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5092885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HF45"/>
    <dbReference type="OrthoDB" id="6516235at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005125">
        <property type="term" value="F:cytokine activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008083">
        <property type="term" value="F:growth factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13752">
        <property type="entry name" value="TGF_beta_INHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.90.10:FF:000005">
        <property type="entry name" value="Inhibin beta A chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.90.10">
        <property type="entry name" value="Cystine-knot cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029034">
        <property type="entry name" value="Cystine-knot_cytokine"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001839">
        <property type="entry name" value="TGF-b_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001111">
        <property type="entry name" value="TGF-b_propeptide"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015615">
        <property type="entry name" value="TGF-beta-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017948">
        <property type="entry name" value="TGFb_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11848:SF309">
        <property type="entry name" value="INHIBIN BETA CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11848">
        <property type="entry name" value="TGF-BETA FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00019">
        <property type="entry name" value="TGF_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00688">
        <property type="entry name" value="TGFb_propeptide"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00669">
        <property type="entry name" value="INHIBINA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00204">
        <property type="entry name" value="TGFB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57501">
        <property type="entry name" value="Cystine-knot cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00250">
        <property type="entry name" value="TGF_BETA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51362">
        <property type="entry name" value="TGF_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 8" id="KW-0339">Growth factor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="domain" description="TGF-beta family profile" evidence="9">
        <location>
            <begin position="158"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAG5092885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="276" mass="31608" checksum="ECDAA355EBC98081" modified="2022-05-25" version="1">MSSGEPALEPLKIKRAILWARVELKHVHHYQHHRRQINLRNITLWVFKVRCGNTTHLRGKELSEHLEMVTSLTVNVGQLGWQKFDVTKIVNSWYTSHKHIKERLTLLVDCTGCSTHVHISTFNVQASRVAGSSIDSKSAQDPDRPFLVVRTDPAAIKRVRRRAIECSGALKGQCCKQRFYVSFSQLGWDDWIIAPQGYYANYCRGDCAAGHRTPDTFLNYYTHVIEEYRKMDRLAGMQPCCAPLKFSPMSLIYYGPDSNIIKRDLPKMVVDECGCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HF90</accession>
    <name>A0A8J2HF90_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similar to ALG13: Putative bifunctional UDP-N-acetylglucosamine transferase and deubiquitinase ALG13 (Homo sapiens)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS8976</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5097985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HF90"/>
    <dbReference type="OrthoDB" id="10017659at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="395"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="434"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="395"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="451"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="514"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="532"/>
            <end position="552"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5097985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="680" mass="77378" checksum="A086B06443BCA6E9" modified="2022-05-25" version="1">MMEIEAMSLLYKRDFVIFFGGHTTELKKKIVINNGFNKYIYLCHTPPRHYETVYKNQIMATAAFCQSIVYKILYQNVFKMPDIETTVEKMLHDDASYEDKASCTELSIPPIPYRVAKALDPNIYRNTDFDIWYELRSQVRTTGLLRWNNYRLQVGGKCFVKISQEDLSRQHGYNNHNNSNKYNNNLRMMNRGEPLIFFGHIQEMAPNKGPAVVFIEDLGENRTNTQPQTPPKVPAENHKQNFNSVPETRDFEKTNGAEDGKKFVEDKSFDTCEVQEKKEIQSNGPNPPSNFPGELILCNDMNCIQSSNEACFNLPNPYCDERNVGESHSFPPAGFINYSSQVVNFRVAPSLDINGNDLPYSDISTLRYFFNLGLEYFNMNHVWWPQNEITYPAAPPNTPLSPPPSPPRSLNIIPPENPPVPVVDQCYAPLPPPVSEIIPQRYDNSDYHKNYSPTNRPKQQQQQRYTSPGFNDNPNENSPFQMKMPSKKKSPTNNKFTSKSKNEQDQKSYNPPQEENHFKRYDKKIIHDNQKKNQSTVPEMHNQSPSHCAVPQQMNYASGPYYLNESENNVSVNVYGSPPPGPPGNVYPIPYIPHAGDVPAEVNNFSAPMMFTNPGNYPPSLPPMYPPVMYPPPPLMPHMTHMFNGLPGPNSPVDWCVSPGGQPGCIPYPYPPSQSNEPAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2025-04-02" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HFX5</accession>
    <name>A0A8J2HFX5_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS9431</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5100194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10072397at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="259"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="375"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="424"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="504"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="547"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="832"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="907"/>
            <end position="927"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="970"/>
            <end position="1023"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1121"/>
            <end position="1143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="268"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="375"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="397"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="424"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="504"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="562"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="911"/>
            <end position="922"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="980"/>
            <end position="1001"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1008"/>
            <end position="1021"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1122"/>
            <end position="1136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5100194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="1285" mass="145788" checksum="790207FE6F003366" modified="2022-05-25" version="1">MSKLFCVNVNIVCAYVLDKPAADRPSMAHTALRELVERAVDEARKLPGLGDTVSTRTQQSTSTTVAEQDYEDLLAAAILNKVIEKYQKNADGNVNNSTRKFLKNKNKMMLDKELGDEFANSPENKLRRRICSDPLSLTIEEQIEEITTTYASDEEPECIKNSVLNFSNAKQSWEENWLFQKKKIAIKSEPVAMLVPNPSAEYRALIGDKDAEDTSDLSEFSAQSDDEIDEDLIQVINHVRPEKSSDTKDSEKETLATVTAHLDGQDGQDGHPPKSDKMEPPCNALKETIASNNKDSENLVGDEVIEECVITNGHLEEDIEENYGVKNCLDELVAQVPKTPTSTPARNSLCEYEVTEINKNFCDFDKLNAKLESIDIDDDDDDDDDDDDDDDDYDSLIIENNNEDNNSVENEIEILEIEENTEGKCREAAAKSESKVSGTKSLERSEEVQETDLELSAPPRPGDYLFAGTIAEREHKKWENAAPIENNPYSPENINKRLLERQYATRSSDVTGNSNVLPTSQSPPLQILFGNNRPDIKRFGRDYYINESKSPRGDKFHRPGTSNSSRPSSSLSHHSSSIGSDFEQQVSDGLEKLEESSLRRDLHRRTYRGSNISSHFVTNPLIYMDQSQSNPNLSTKITTDTSTLTNDSFPKFDDNWPHKSDQALFSEHPASDLVTTNPIYEDEVTIRRSGGFAGDRDSGMYSIESNDNDYSNDCDSSLISIDEELDDVLKLDWDSSRSDEPSFSDGRKYWILNSHKFHTFGGIKRRQAKGEYNNLEAKNYILCDDEVVDFSTLKYQTFGGIKHKLDFQEINISKPPRVRSSIKSIESKFSPLSEEINRESNSEDSDSDSDDKFILAHPLEASTLEGDNLRLEPPLVPKEVFEPIEATSKLIASQNNLDRERKNSKNEINAKLNNQSTNNPDCKNSFDEDNKRKIRRIDLRAYGFENEFHVNKDNNNKDLENRRVPNKLDLRSFGYDSGLRRTQSNNNLDSKVNNSFVNLKTNGDDDNNNNNNNNNNNNNNNEELKKSNLIEGYWNKSTEVLNKEKLIVFEKFNRMSSAKSVPNITKTDNYYAIASSSASDEDEKHFVERLTMDNDEIKRYDSSIKDHHRIIKLIDREAENSGDFNSYETDSQSSKTESSEELPRRFSTIKDIKYSLESLDGGDKFVDKELPMPSVKKLAQAFNHTSENTKTPRIIKNVVKDRPTTPEIQIVKTPRQMHSLTARSLSKEFREGLRQISVKPQVQSLIIEATEKNSTNLDKSIDIDVIAPGKIKNELEFWEQLQKQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HGA0</accession>
    <name>A0A8J2HGA0_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Adenosine 5'-monophosphoramidase HINT3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Histidine triad nucleotide-binding protein 3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HICCMSTLAB_LOCUS8918</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>adenosine 5'-phosphoramidate + H2O = NH4(+) + AMP</text>
            <dbReference type="Rhea" id="RHEA:67916"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57890"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the HINT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5097869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HGA0"/>
    <dbReference type="OrthoDB" id="1915375at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001310">
        <property type="entry name" value="Histidine_triad_HIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011146">
        <property type="entry name" value="HIT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12486:SF5">
        <property type="entry name" value="ADENOSINE 5'-MONOPHOSPHORAMIDASE HINT3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12486">
        <property type="entry name" value="APRATAXIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11969">
        <property type="entry name" value="DcpS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00332">
        <property type="entry name" value="HISTRIAD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51084">
        <property type="entry name" value="HIT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HIT" evidence="10">
        <location>
            <begin position="9"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Histidine triad motif" evidence="8 9">
        <location>
            <begin position="100"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-AMP-histidine intermediate" evidence="7">
        <location>
            <position position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00025764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00039802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00042361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR601310-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR601310-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAG5097869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="141" mass="16177" checksum="5FDAECDC6E454A8B" modified="2022-05-25" version="1">MATFQDGCIFCKIVKGESPSESIYEDDDLICIKDINPASDHHYLIIPKNHIANAKELKLEDEPLFDKIVDTVEVVAAQQGLDLGSTRTGFHWPPFNTVNHLHLHVIYPVENMNFLKRQMFRPNSLWFVSTDYVKSRFNVAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HGC9</accession>
    <name>A0A8J2HGC9_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to SNRNP25: U11/U12 small nuclear ribonucleoprotein 25 kDa protein (Homo sapiens)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS6918</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5093571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HGC9"/>
    <dbReference type="OrthoDB" id="72819at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005689">
        <property type="term" value="C:U12-type spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17058">
        <property type="entry name" value="Ubl_SNRNP25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039690">
        <property type="entry name" value="SNRNP25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040610">
        <property type="entry name" value="SNRNP25_ubiquitin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14942">
        <property type="entry name" value="U11/U12 SMALL NUCLEAR RIBONUCLEOPROTEIN 25 KDA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14942:SF0">
        <property type="entry name" value="U11_U12 SMALL NUCLEAR RIBONUCLEOPROTEIN 25 KDA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18036">
        <property type="entry name" value="Ubiquitin_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="163"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="SNRNP25 ubiquitin-like" evidence="2">
        <location>
            <begin position="65"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5093571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="191" mass="21517" checksum="22F76C744C6ECA24" modified="2022-05-25" version="1">MAEETKNLNQESNNEAHFSHEELVKLTQEAIDKIIESDPLFSGLPSDVTIEELKSQTAVAQGQAITLYLNRGELPRLYIVVSPNSTTVLDLKKAIKRQTTLALCRERVKKKISWKHVWKKYDLCFDGVPLNNDNENIKNYGIANKVELQYVKKRREKNKIGETFFSSSGSSAALVSVGISTLGIFLTLIFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HGY3</accession>
    <name>A0A8J2HGY3_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">vesicle-fusing ATPase</fullName>
            <ecNumber evidence="1">3.6.4.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HICCMSTLAB_LOCUS9852</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.6"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.6" evidence="1"/>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5100779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HGY3"/>
    <dbReference type="OrthoDB" id="27435at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034098">
        <property type="term" value="C:VCP-NPL4-UFD1 AAA ATPase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031593">
        <property type="term" value="F:polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097352">
        <property type="term" value="P:autophagosome maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051228">
        <property type="term" value="P:mitotic spindle disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060341">
        <property type="term" value="P:regulation of cellular localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030970">
        <property type="term" value="P:retrograde protein transport, ER to cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19528">
        <property type="entry name" value="RecA-like_CDC48_r2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:004781">
        <property type="entry name" value="Bromodomain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000004">
        <property type="entry name" value="Cell division control 48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.330.10:FF:000001">
        <property type="entry name" value="Cell division control 48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002861">
        <property type="entry name" value="Cell division control protein 48 homolog E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.40.20:FF:000003">
        <property type="entry name" value="Transitional endoplasmic reticulum ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000048">
        <property type="entry name" value="Transitional endoplasmic reticulum ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.20.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050168">
        <property type="entry name" value="AAA_ATPase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009010">
        <property type="entry name" value="Asp_de-COase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004201">
        <property type="entry name" value="Cdc48_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029067">
        <property type="entry name" value="CDC48_domain_2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003338">
        <property type="entry name" value="CDC4_N-term_subdom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015415">
        <property type="entry name" value="Spast_Vps4_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077">
        <property type="entry name" value="AAA-FAMILY ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077:SF171">
        <property type="entry name" value="NUCLEAR VALOSIN-CONTAINING PROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02933">
        <property type="entry name" value="CDC48_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02359">
        <property type="entry name" value="CDC48_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09336">
        <property type="entry name" value="Vps4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01072">
        <property type="entry name" value="CDC48_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01073">
        <property type="entry name" value="CDC48_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50692">
        <property type="entry name" value="ADC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54585">
        <property type="entry name" value="Cdc48 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CDC48 N-terminal subdomain" evidence="8">
        <location>
            <begin position="24"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="CDC48" evidence="7">
        <location>
            <begin position="124"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="6">
        <location>
            <begin position="236"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="6">
        <location>
            <begin position="484"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="744"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="755"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="767"/>
            <end position="777"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAG5100779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="777" mass="86779" checksum="32C4616A9FF604EF" modified="2022-05-25" version="1">MTKHREKFDDLATAILRKKDKPNRLLVEEAVSDDNSVVALSEAKMCELQLFRGDTVLLKGKRRKETVCIVLSDETCPNEKIRMNRVVRNNLRVRLSDVVSIQPCPSVKYGKRIHVLPMDDTVEGLTGNLFEVYLKPYFLEAYRPVYKDDNFIVRGGMRAVEFKVVETDPSPYCIVAPDTVIHCEGDPIKREEEEEALNAVGYDDIGGVRKQLAQIKEMVELPLRHPSLFKAIGVKPPRGILLYGPPGTGKTLIAQSESNLRKAFEEAEKNSPAIIFIDELDAIAPKREKTHGEVERRIVSQLLTLMDGMKQSSHVIVMAATNRPNSIDGALRRFGRFDREIDIGIPDATGRLEILRIHTKNMRLADDVELEQIAAETHGHVGADLASLCSEAALQQIREKMDLIDLEDDQIDAEVLASLAVTMDNFKYAMTKSSPSALRETIVEVPTVTWDDVGGLQNVKKELQELVQYPVEHPDKFLKFGMQPSRGVLFYGPPGCGKTLLAKAIANECQANFISVKGPELLTMWFGESEANVRDVFDKARSAAPCVLFFDELDSIAKSRGGSVGDGGGSADRVINQILTEMDGMGAKKNVFIIGATNRPDIIDPAILRPGRLDQLIYIPLPDEKSREAIFRANLRKSPVAKDVDLTYIAKVTHGFSGADLTEICQRACKLAIRQCIEADVRRERERMDNPSVSMDMDEDDPVPEITRAHFEEAMRFARRSVSDNDIRKYEMFAQTLQQSRGFGTNFRFPQNAAGGTQDTTQGDQTFQDDGDDDLYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HH92</accession>
    <name>A0A8J2HH92_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS7813</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5095647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HH92"/>
    <dbReference type="OrthoDB" id="2017365at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="226"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="433"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="131"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="168"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="226"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="441"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="462"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="486"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="537"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="594"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="615"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="628"/>
            <end position="637"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5095647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="637" mass="68493" checksum="A4515E8D4F1FA177" modified="2022-05-25" version="1">MSTSTMPGVGTTPPSSGHSMLPMNVMAQKVMPGGDPGSMKPLSGGNLSYVTLQPASQPLSLVQDHRSQVYPTSAPYNQSASAQPSSVTPGSNINVPAEREKEAGDSTDNKSTHNGVEVAVKIPGAGLPVDQESNLQTKQSQEANRNNNVSPESSSTGSQDDIKSEPQSSAVIESSVAVSAAPKAEEKKILVNNGTKEADNCPTLVTVQNKVSPQKTEDTLAKVDAVVSTKKVPTTPTKAAASESSSPATTMTKAEQKLNSPVRAPKRKSRELKDLKSPSAEGGSKPKRNRVQTQPYQSPLPEIALIVKQTLNKAPANKNPDDKLIVFYKNEFLAVRNAEGSFYVCQAMQNIFKSSRRIRIRWLSQDKNNGEIYSPDFYDFTDFDCILTNLNLNKVDKNKYQLTKFELLRTENILKRAIDVEAGVSEKPMDLSLYKDESQLKRRKGSSKPKQRQRKRSKRESSSSSSSSSSSSEDDSSDEEVDKKSTTAAATTTTTTTPKSSRAKKRPATNNKALAIAKSVANVSSRAKRIMNRSSKTDASNDNSGNSGDTNASSTRADAGAGKRPSNTDVKKTEPKKTTKPPPSVPSSTRTKLRGSTQIAETSSNNSTRRGKRLAAATTGVTSTVDSSSEKKSRSRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HHH8</accession>
    <name>A0A8J2HHH8_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Similar to TAF3: Transcription initiation factor TFIID subunit 3 (Homo sapiens)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HICCMSTLAB_LOCUS9373</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5100078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HHH8"/>
    <dbReference type="OrthoDB" id="7633995at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002039">
        <property type="term" value="F:p53 binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15522">
        <property type="entry name" value="PHD_TAF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46452">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46452:SF1">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="6">
        <location>
            <begin position="412"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="246"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAG5100078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="480" mass="54912" checksum="A014F4CE8017EC89" modified="2022-05-25" version="1">MVDLLDEYLRQMGQISHNYAEVLGRTDIDLQDVSLIFQNMNADLDQLAEYVKNAGSVPCVIQVSKYPIPRKDHFNFMDPEIRKRPMYSNFNELSDEEKEIFKAENININNNQRDVIKRPGNRLFGGLASGKRSKLSSSELMRKVHSVVMTTSGFLAPVCEGKLPESWTSVENHREFYEEPEISIIDEYKNENLKLPVRESTNLIINTEIPKIKISKVESLANLPQEREKWSVNSVNTPNLSPENQLSLKNKQITDKNDELKKFKEKNKKHRKDKKKAKEDDIIIVYPLDTPVSQSLEKKSIKDKNIKISSNLYSPILPSGVKLEKIEEKKKCKADTKINSAKSSEDLVEKVTLEFPEEIDDAESDLVILPSLVVKRKVKQKKILKNVKKRRKQVEKVLTVVAPKYGTDGKRIWICPPCGREDDGTPMIGCDDCNDWFHWVCIGMRVPPPDEANWYCKPCLAKKRKEGTGGSKKKSQGVIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HI81</accession>
    <name>A0A8J2HI81_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS10680</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5101779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HI81"/>
    <dbReference type="OrthoDB" id="7550839at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5101779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="249" mass="28313" checksum="C60A0023B0630B1A" modified="2022-05-25" version="1">MKRSTARGQAIRIASIVPHQFVSSIFSLATAMIFWDFFFLVTAYQVHLSYQKTVPTSVYRREPSREVKEGDTVIENKNVNIVVNVDPKEVAKELWKILEKRMDNPPSRRSQTSKDMIKELETIVSPIVLPSRRANEPSAFEIADALDHVTRKALQGDSVERSSIEKEILTRNIVANMMKTLNDVKKVESQLSLPSEGVINYEQTRKSLLLINQTDNVSAESGEDEYVELIIKIRRSALQGSQDLKYVFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HI88</accession>
    <name>A0A8J2HI88_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS9677</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5100604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HI88"/>
    <dbReference type="OrthoDB" id="7489672at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5100604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="201" mass="22739" checksum="04A2699631332C7D" modified="2022-05-25" version="1">MKPVEQPDGSLLINCTTSIMQIVLRMFKNTPSCQIAIKCNQCLQEDLKDVIAPFLYMADIKSGLLDLTTLSNLSMKSRCQTLACNGYRETSIASTGDMVIFEIFNADENQVVKLNSLPKGFENPINADEKYRLVGVVDLTQRATRRRSHENINSEVGTMGHFTAICLRGTEWWEYDDTQDQPRMKKGSAYVNAQILVYVRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HJ00</accession>
    <name>A0A8J2HJ00_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="18">Similar to Sulf1: Extracellular sulfatase SULF-1 homolog (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">HICCMSTLAB_LOCUS8750</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell surface</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Golgi apparatus</location>
            <location evidence="4">Golgi stack</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the sulfatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5097533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="96314at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005795">
        <property type="term" value="C:Golgi stack"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005539">
        <property type="term" value="F:glycosaminoglycan binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008449">
        <property type="term" value="F:N-acetylglucosamine-6-sulfatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16147">
        <property type="entry name" value="G6S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.720.10:FF:000050">
        <property type="entry name" value="Extracellular sulfatase SULF-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024609">
        <property type="entry name" value="Extracellular_sulfatase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024607">
        <property type="entry name" value="Sulfatase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43108:SF16">
        <property type="entry name" value="EXTRACELLULAR SULFATASE SULF-1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43108">
        <property type="entry name" value="N-ACETYLGLUCOSAMINE-6-SULFATASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12548">
        <property type="entry name" value="DUF3740"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00523">
        <property type="entry name" value="SULFATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0106">Calcium</keyword>
    <keyword evidence="13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 15" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035301230" evidence="15">
        <location>
            <begin position="22"/>
            <end position="1400"/>
        </location>
    </feature>
    <feature type="domain" description="Sulfatase N-terminal" evidence="16">
        <location>
            <begin position="71"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="domain" description="Extracellular sulfatase C-terminal" evidence="17">
        <location>
            <begin position="750"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="480"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="869"/>
            <end position="1011"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1075"/>
            <end position="1108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1136"/>
            <end position="1158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1366"/>
            <end position="1400"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="833"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="1174"/>
            <end position="1224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="493"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="880"/>
            <end position="914"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="918"/>
            <end position="944"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="961"/>
            <end position="981"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="984"/>
            <end position="993"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="994"/>
            <end position="1009"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="1082"/>
            <end position="1108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="1371"/>
            <end position="1386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00008779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF12548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="CAG5097533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="1400" mass="161347" checksum="F70881E1CE3B731D" modified="2022-05-25" version="1">MHVLLQAIELLLLAVVVGSNARRDEILNEDLFGGQRTRGNFNINSNSNINYNSQQQHNSPFLPNYQRERKPNIVLILTDDQDVELGSLNFMPNTLRRIRDEGAELRHAYVTTPMCCPSRSSLLTGRYVHNHQVFTNNDNCSSPQWQRDHEPHTFATYLSNAGYRTGYFGKYLNKYNGSYIPPGWREWGGLIMNSRYYNYSVNMNGKKIKHGFEYSKDYYPDLIANDSVAFLRQSKHNFARKPVMLVASFPAPHGPEDSAPQFSQLFFNVTTHHTPAYDYAPNLDKQWILQVTQKMRPIHKQFTDLLMTKRLQTLQSVDAAVERIYQELKDLGELDNTYIIYTSDHGYHLGQFGLIKGKSFPFEFDVRVPCLIRGPGIAPGSVVDEIVLNIDMAPTFLDIAGVDTPPQMDGRSFKKLFLTNKHGRRAKFKWPDTFLIESSGRRETPESIAEAKAREARRQNATLVKQLLDPTPDELAIDTDTEFEGDRLLDNDTGSDQDISDDDDLEDSITDESNGDVHLDNGVNPSLNLNSKHERLTYECSRPEAQTNCLPGQKWRCEKEGHRWRRHKCKYTTTASSITSGTAHKSSKKCACFTPNGVVYTRLESNDFPRDNRGGLYDDGEGFLSGGRGKRSIVDREKIKHDVKLEFKSTQSGYYGEDDLRDRRAIDEEDDEKFIEELEILREELLHERNKRDVNENTINFMGDRLIGYSKYLVNNSVKEDDYDDDNKDETDYSVNDFDFTSLNKIVKKFINVDDILKRHRRVRRSVTKKDTIEHVTKIMESIEEELDDLKESQVRQSNGTEVISPKCLVLPKGGVNCTTSVYQDPNEWKQSRRAIEKQIKEMRIQLESLKEIRRHLMDKRPHFIPEDDDYSEVDDLHPHEHHYHNNSNNHHHNSHHHHHHHNKNHTRHHKKHDKLPVSTTGSSTQVYYSSTTSFSSTSSGSTSEEITETPAPEGLDRSYDSATQGKITTSELPRTTTVPTTIKAKKSSRRQKINKDNVDVRTDEEDKPRRRKIHHHKLNKFNNSINNNTLLTNSVNDNNLNVNSNVSSDNWPIREEKESTVDVIKNNVKDYSTTARQSVSTTPMSTRASTTASPTTTTTTTTPATTTTITTKKPLKIIKNRTGLGPARIDVTILEPPDRKHKQPGSMSNNGPPPPLINNPLESRYKCYCEPDNQPKKDEKEIAKEERRRLKEERLRKKERKLKKKAKLEKECLTEKMNCFEHDNDHWRTAPLWNAGPFCFCMNANNNTYSCVRTINVTHNFLYCEFTTGFATFYNLRIDPFEQWNRLGSLTPAERSYLHDQLEHLKGCKGTRDCTVGNAKEAIATNTVQQQRFLTKRKYSNSFEDMFIPSALQIIRESELGSNKRRKKVSNSWNRRSRSWQSNWKHAADKVSRRHRHPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HJ36</accession>
    <name>A0A8J2HJ36_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS8419</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5096855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HJ36"/>
    <dbReference type="OrthoDB" id="7699186at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34239">
        <property type="entry name" value="APPLE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34239:SF2">
        <property type="entry name" value="TRANSPOSABLE ELEMENT P TRANSPOSASE_THAP9 CONSERVED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="13"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5096855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="310" mass="35015" checksum="921ECC4C2AEA1F08" modified="2022-05-25" version="1">MSTETDTAELIREIRQGRRHYEPGNNAVQPQTEKQIPVIDIGKENEVTQKQKDTQPVNASEKSSDLDPEILKIIGETPSTEPEGLKLSNHISDRWKNWLKTGQTKEAKELLLKKYPRKGECSLEAPKLNPEIAASLNEGSLKRDKYFSNTQNLAGSALSALSLVIDPILTKKREEIDVKKMLENLWESSRILTELFRGQTVARKACILPSLNKQTASLLDKTETGKFLFGEKLGEKIKESKVIDKISTDIKSQLPLKKPGTRLTDKKRETILCHINTLLKKQECKIRFLAQVIGTLTAACPAVEYERDRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HJK4</accession>
    <name>A0A8J2HJK4_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Similar to Mkp3: Dual specificity protein phosphatase Mpk3 (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HICCMSTLAB_LOCUS11490</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5103399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HJK4"/>
    <dbReference type="OrthoDB" id="165342at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033550">
        <property type="term" value="F:MAP kinase tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017017">
        <property type="term" value="F:MAP kinase tyrosine/serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008330">
        <property type="term" value="F:protein tyrosine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043409">
        <property type="term" value="P:negative regulation of MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01446">
        <property type="entry name" value="DSP_MapKP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14566">
        <property type="entry name" value="DSP_MKP_classII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.10:FF:000004">
        <property type="entry name" value="Protein phosphatase Slingshot homolog 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000340">
        <property type="entry name" value="Dual-sp_phosphatase_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008343">
        <property type="entry name" value="MKP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10159">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10159:SF519">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN PHOSPHATASE MPK3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00782">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01764">
        <property type="entry name" value="MAPKPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00195">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="Rhodanese/Cell cycle control phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50054">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rhodanese" evidence="10">
        <location>
            <begin position="27"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="8">
        <location>
            <begin position="203"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="9">
        <location>
            <begin position="267"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="177"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAG5103399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="399" mass="44188" checksum="6D913A9934E21C08" modified="2022-05-25" version="1">MPGEGMVEEEGYVGHEWFFRELRSQGGPDRLLILDCRAHSDFLEAHIRNSVPLAIPSIMLRRLAAGKVDLLATIRCLELRNRVEVFLYGDDDRRGTFVLIGDSTDPAGHQGETIQVLSRRLKSSGGYVVTLIGGFGAFRDRYPEWCEGSQANAEGQPGQENNVGELMGLRTLRISTPPTRAYSDSDSDSTCDSVVGPEEDKDFPVEILPHLYLGNAANSEDHDSLSRHRIQYILNVTADLPNVFEDAGSIKYMQIPINDHHSQNLASFFPQAIQFIEEARSSDKGVLVHCLAGVSRSVTITIAYLMHKCNLSLNDAFNLVRSRKTNVAPNFSFLEQLYRFESELRDRGDRKRNNRCIGACQPGGPCNCPAPSFLSPVDLGPSPDSGIEFDKWAASTPAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HK01</accession>
    <name>A0A8J2HK01_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Similar to bab2: Protein bric-a-brac 2 (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HICCMSTLAB_LOCUS8917</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5097867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HK01"/>
    <dbReference type="OrthoDB" id="10261408at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051095">
        <property type="entry name" value="Dros_DevTransReg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23110">
        <property type="entry name" value="BTB DOMAIN TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23110:SF102">
        <property type="entry name" value="PIPSQUEAK, ISOFORM O"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="3">
        <location>
            <begin position="45"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG5097867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="106" mass="11867" checksum="4636B153AA1FD23C" modified="2022-05-25" version="1">MEAARYWGVHYSGGMAGQHYCLRWNNYQSNMTSVFHQLLQTEAFVDVTLACNEASLKAHKVVLSACSSYFKKLLLSNPCKHPTIIMPQDVCFNDLNTVILCTSSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HKA8</accession>
    <name>A0A8J2HKA8_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Similar to rbm46: Probable RNA-binding protein 46 (Danio rerio)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HICCMSTLAB_LOCUS10216</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5101143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HKA8"/>
    <dbReference type="OrthoDB" id="3800936at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000022">
        <property type="entry name" value="APOBEC1 complementation factor isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21245">
        <property type="entry name" value="HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="60"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="140"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="313"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="322"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAG5101143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="482" mass="55350" checksum="82C7473ED3985968" modified="2022-05-25" version="1">MENYSSEMSELVEKTNECCISERLIDLMNRTHYELVQENGQRRLTAPELTKEYRDRIKGAEVFLGRLPRNCYEDELMPVLEKAGRLLELRLMLDFSGTTRGYAFALYEDAKTARRARTMLDGYEIRPGHKIGVVKSIDNCRLFFGGVPKDKKKAEFVEELGKILDGISDIYLYPNAQDRTQNRGFIFVEFKDHRSAAMARRKLIPGRVMLWDHEVAVDWADPEPGESLDDELPHQKVREVFHRTTGVPILKLKKINHFAFVHYETREMAKKVLEIMNAPNGIAEIQQWEICWAKPIGSTKIQERQRAIQEAAGTEKFRDNQVLPQNNQPNGTNNKRQSTKKKSKNVEPRSPDVNRSLPSTVSTSPEIGRVTIAPISPPCIIPTDYKKILENFIAQKFGARCHFICMQMFVPVGFICKISIVCNNQIMYEFQGQLYQTQNQAINLTSREVYYQLVNNSTMPVIVPPNVYSSSNYLFGQSQACH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HKJ2</accession>
    <name>A0A8J2HKJ2_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RBR-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="4">2.3.2.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">HICCMSTLAB_LOCUS10336</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.31"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RBR family. Ariadne subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.31" evidence="4"/>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5101263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HKJ2"/>
    <dbReference type="OrthoDB" id="10009520at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20344">
        <property type="entry name" value="BRcat_RBR_TRIAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20360">
        <property type="entry name" value="Rcat_RBR_TRIAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16773">
        <property type="entry name" value="RING-HC_RBR_TRIAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1750:FF:000004">
        <property type="entry name" value="RBR-type E3 ubiquitin transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000019">
        <property type="entry name" value="RBR-type E3 ubiquitin transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045840">
        <property type="entry name" value="Ariadne"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047555">
        <property type="entry name" value="BRcat_RBR_TRIAD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031127">
        <property type="entry name" value="E3_UB_ligase_RBR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002867">
        <property type="entry name" value="IBR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047556">
        <property type="entry name" value="Rcat_RBR_TRIAD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044066">
        <property type="entry name" value="TRIAD_supradom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11685">
        <property type="entry name" value="RBR FAMILY RING FINGER AND IBR DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19422">
        <property type="entry name" value="Ariadne"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01485">
        <property type="entry name" value="IBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22191">
        <property type="entry name" value="IBR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26000">
        <property type="entry name" value="UBA_ARIH2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00647">
        <property type="entry name" value="IBR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51873">
        <property type="entry name" value="TRIAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <keyword evidence="8 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="16">
        <location>
            <begin position="130"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="15">
        <location>
            <begin position="134"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="15">
        <location>
            <begin position="295"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="442"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CAG5101263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="503" mass="58488" checksum="DFF899EE381D043E" modified="2022-05-25" version="1">MSTEEFDSDMEYSDSDCGDNGYEDYYNNQHWGSETDNDFDSDHNKKDPEYAIHDCLRVEEVERLLNENVEVLSTNLHITPSLAKVLLHTHNWALQDVLAKYRTNASSLLVNSKIKSPHPPDPASAMKAQKGGQCSVCITNYPPEKFATLTCGHAFCKDCWCMHFEVQIFQGISTGIECMAQGCGVLVPEDFVLSLLTKPNMRDRYQSFAFRDYVKTHPQLRFCPGPNCQIVMKSKERRAKRVICLSCKTIFCFCCGMDYHAPTDCKTIKMWLTKCADDSETANYISAHTKDCPKCHICIEKNGGCNHMQCYNCKHEFCWMCLGDWKTHGSEYYECSRYKDNPNIAHESSHVQAREALKKYLHYYERWENHSKSLKLEEQTLENIKSRINKKVMNASGTWIDWQHLFGAASLLARCRYTLQYTYPYAYYMEPGPRKQLFEYQQAQLEAEIENLSWKIERAETTDRGDLENQMDIAEKRRVTLLKDFLDDAVDYNNKYYQEDQRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HLH2</accession>
    <name>A0A8J2HLH2_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS10487</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5101585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HLH2"/>
    <dbReference type="OrthoDB" id="8194095at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035265342" evidence="2">
        <location>
            <begin position="18"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="102"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="134"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="153"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5101585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="201" mass="21461" checksum="DF16F965D74C4AF5" modified="2022-05-25" version="1">MVNLLLLSLATLASAYASVIPEISGYSRVSTNGASSASEPRSLNPSPVYHPAKHLKVYDGEVVDYSHKYSTLDKEMVAKLDGKTRQKQAEDRFVPSAVRLQSPSGSPGSSSSLASQSSVSGSSPSISSGGYATLPQSYSSNTYQFPDDDKSPKNNNNNKFKIANSNGNNNDHDNLPSITADGFSIAGNSYSKIHMNYNLTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HLJ8</accession>
    <name>A0A8J2HLJ8_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS8199</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5096417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HLJ8"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5096417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="104" mass="12436" checksum="3BB1869AD82EADF9" modified="2022-05-25" version="1">MKNTYGIMAGFSLFDILHRSYHKLALRFKDGDEDKLDDKMAAKFSLYAGMIKYRLEKAGQRRKLFKQVENVLYKIYSRYLPATFIHEMFFYFSNIELSKLVEIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HMV6</accession>
    <name>A0A8J2HMV6_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Bestrophin homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HICCMSTLAB_LOCUS9154</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Forms chloride channels.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the anion channel-forming bestrophin (TC 1.A.46) family. Calcium-sensitive chloride channel subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5099627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HMV6"/>
    <dbReference type="OrthoDB" id="201595at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034707">
        <property type="term" value="C:chloride channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005254">
        <property type="term" value="F:chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000615">
        <property type="entry name" value="Bestrophin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021134">
        <property type="entry name" value="Bestrophin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10736">
        <property type="entry name" value="BESTROPHIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10736:SF0">
        <property type="entry name" value="BESTROPHIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01062">
        <property type="entry name" value="Bestrophin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0868">Chloride</keyword>
    <keyword evidence="6" id="KW-0869">Chloride channel</keyword>
    <keyword evidence="6" id="KW-0407">Ion channel</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="31"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="65"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="235"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="266"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="386"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="487"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="531"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="583"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="390"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="542"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="552"/>
            <end position="562"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00034769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG5099627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="641" mass="73293" checksum="DC8CBF4853C88A7D" modified="2022-05-25" version="1">MTVSYQYEVASSTSGGFTRLLFMWRGSLYKLIYRELLLFLVVFGIISVIYRHALTTPHKRAFERIVIYCDTFVSLIPLSFVLGFYVAYVAGRWWQQYMAIPWPDKVMHLVALYVTGNDEYGRMLRRSLMRYLNLSLILVLRSISSAVKRRFPTLDHVVDSGFMTALELELFQSVPSLEFNTYWIPCTWFINLLKESRRTHRLPDPQGLKIIMEEFNEFRSKCGLLWSYDWVSIPLVYTQVVTLATYSFFVVALVGRQYIEGSKKPFQMALDAYLPIFTILQFFFYMGLLKVAEQLINPFGDDDEDFELNWLIDRHTKVSYLGVDTLMNRCPPLVKDFYFDSENIVLPYTEAAAAYKRKTYRGSVANMTVPEEKQTMFLPDIIEEEDETSHPATPKTSSIIGSPSATPKKTESTTETIIQLDNPEPVESLASELSIDRSQHTPGAVKRNSRSLQWLELNRKRFIPLAKLSRVSVQPWPSATNLQESTLSYETPKSSSLQSPPPSISVSCGSDEPNDDLQGFFNSAFSQEHLPDTDKSLKQQASEESNSAVASKSKKSRTRFLVRRQSSVSSSKKRKIFRWKRPLDSTQSRRKTTDCVPSPADIIPQTSSSPDLESFTAIDVIIPPRAASEDRDHALDLFTKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HPE0</accession>
    <name>A0A8J2HPE0_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS11536</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5103491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HPE0"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5103491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="82" mass="9212" checksum="E9E56467703457ED" modified="2022-05-25" version="1">MKTEKKQENRLVVIKILFPLFTLQCTCDASTYLPLLYHSLNTSKEYNRSEYIVNVSAVAATTVTLLPASDSILLVMLSRSKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HPP8</accession>
    <name>A0A8J2HPP8_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HICCMSTLAB_LOCUS12020</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5104474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HPP8"/>
    <dbReference type="OrthoDB" id="8915289at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004714">
        <property type="term" value="F:transmembrane receptor protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007169">
        <property type="term" value="P:cell surface receptor protein tyrosine kinase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050122">
        <property type="entry name" value="RTK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416:SF550">
        <property type="entry name" value="FIBROBLAST GROWTH FACTOR RECEPTOR HOMOLOG 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="168"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="264"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="349"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAG5104474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="443" mass="49839" checksum="B297D09ABA513576" modified="2022-05-25" version="1" fragment="single">MYFNYIILIFFGSIINFVYNANPSNVSIINNNVSGAPQDLRVEIFDEFGNINDDNSHDSVLKFNFSWLPPSSWYPTSYSIFINSMTVDQKNTISCPEESIFYTTTDDNLFNIVLPENSLLSDINITVPTCIGKLCNCDEASKLLPSVEVNASIPDSKSILISWSTIQLLNATAISSFIVGYSIPILISKNGIPVYNLTKLTSAPSNSRSYIWHTEPSVNSIFDKEMKIFVAAEDIYGCRGRMSYYTIKTDVQPLLMSITYSNQWIIWSTVLVICSIIIGLFTYIRNRGHENYKFILSNHVTSGISSIRISERNGWINTVLKKKNMLYADEIIETTETIADGYEISYDRIKISSELGKGQFGKVYLGYLDSVTNNNNNNNNNNNEEEESGFPVAVKMMNPGNVDDKTEAHRQLVYEIGTMKRAGSHPHLVKLIGCCTKLENPIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HPV1</accession>
    <name>A0A8J2HPV1_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similar to hlh-13: Helix-loop-helix protein 13 (Caenorhabditis elegans)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS10787</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5101982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HPV1"/>
    <dbReference type="OrthoDB" id="6125763at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032502">
        <property type="term" value="P:developmental process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050283">
        <property type="entry name" value="E-box_TF_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23349">
        <property type="entry name" value="BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTOR, TWIST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23349:SF97">
        <property type="entry name" value="BHLH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BHLH" evidence="1">
        <location>
            <begin position="119"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5101982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="239" mass="26906" checksum="92C6A7843FCD6E72" modified="2022-05-25" version="1">MASHLAYNYEERGHRITSRHRVIPGSHKPADSICANTRYYAGNGGGGGSDISEEDLTDLPSCAYAGRSTQHVAAHTSPHSHTHLPLQYNMPLSTQDHNDNDLNGFEEGYYPNGSPYRIQRNAANIRERRRMLSSINSAFDALRGHVPTFPYEKRLSKIDTLRLAIAYIALLTEVLKVKNVDPLTYIEMCLRGEMSGERAEWNTSDLMARLAWINWENLGVNPNRRSSLTTLTFTTDNLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HPW5</accession>
    <name>A0A8J2HPW5_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Similar to IGF2R: Cation-independent mannose-6-phosphate receptor (Homo sapiens)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HICCMSTLAB_LOCUS12714</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5107368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HPW5"/>
    <dbReference type="OrthoDB" id="4504960at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005537">
        <property type="term" value="F:D-mannose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038023">
        <property type="term" value="F:signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007041">
        <property type="term" value="P:lysosomal transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.130.10">
        <property type="entry name" value="Mannose-6-phosphate receptor binding domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000479">
        <property type="entry name" value="CIMR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009011">
        <property type="entry name" value="Man6P_isomerase_rcpt-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044865">
        <property type="entry name" value="MRH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15071:SF0">
        <property type="entry name" value="MANNOSE 6-PHOSPHATE RECEPTOR-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15071">
        <property type="entry name" value="MANNOSE-6-PHOSPHATE RECEPTOR FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00878">
        <property type="entry name" value="CIMR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01404">
        <property type="entry name" value="CIMR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50911">
        <property type="entry name" value="Mannose 6-phosphate receptor domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51914">
        <property type="entry name" value="MRH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035266489" evidence="8">
        <location>
            <begin position="20"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="domain" description="MRH" evidence="9">
        <location>
            <begin position="27"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="domain" description="MRH" evidence="9">
        <location>
            <begin position="172"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="domain" description="MRH" evidence="9">
        <location>
            <begin position="323"/>
            <end position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAG5107368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="458" mass="50710" checksum="48C8922E40D01E44" modified="2022-05-25" version="1">MGRLIILVLLASECYFGECNKQVIPPSYCEIDLGVHALKFDFRKLSEVNDDYILEHESTNETIKFQLCKPLKKTCNEASGVAGCLIRGNEQIILGKVPEVQHEDGRISFSYVGEKCGEKIYYSFNVIMICDSQAEYSYPELFPYDQKQCNFIAVWKTKLACGVNFEASEHSVDCKVTDEKTKTFYDLGSLKKTSDNYIVHIDNKSSIILNICHTVVFGSGVVCPFSAACLRNSTNSTIYSSIGDVASPKIVNGSVTLTYSTGALCADMTHSDTTISFVCDFKAYETQPALGQLKDDCHYNIIWKTIAACDNKKAEEYKQKTSASCKFTNPITNYEYNLDSLKGEDYIVRSANDEYKFSVCGPLLTNFCKKGNDDSAGVCSAHNRIVGGKANSKLISTVGGLYLNYTDGSSCQGNRSRFTIIAFRCSPEGSEAVPIITEESTCHLVIQWNTSLACEKKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HQ84</accession>
    <name>A0A8J2HQ84_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">tRNA (guanine(26)-N(2))-dimethyltransferase</fullName>
            <ecNumber evidence="7">2.1.1.216</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HICCMSTLAB_LOCUS12170</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>guanosine(26) in tRNA + 2 S-adenosyl-L-methionine = N(2)-dimethylguanosine(26) in tRNA + 2 S-adenosyl-L-homocysteine + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:43140"/>
            <dbReference type="Rhea" id="RHEA-COMP:10359"/>
            <dbReference type="Rhea" id="RHEA-COMP:10360"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="ChEBI" id="CHEBI:74513"/>
            <dbReference type="EC" id="2.1.1.216"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the class I-like SAM-binding methyltransferase superfamily. Trm1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.216" evidence="7"/>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5106258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HQ84"/>
    <dbReference type="OrthoDB" id="6349953at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160104">
        <property type="term" value="F:tRNA (guanine(26)-N2)-dimethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002940">
        <property type="term" value="P:tRNA N2-guanine methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.56.70:FF:000001">
        <property type="entry name" value="tRNA (guanine(26)-N(2))-dimethyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.640">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.56.70">
        <property type="entry name" value="N2,N2-dimethylguanosine tRNA methyltransferase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014752">
        <property type="entry name" value="Arrestin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011022">
        <property type="entry name" value="Arrestin_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002905">
        <property type="entry name" value="Trm1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042296">
        <property type="entry name" value="tRNA_met_Trm1_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00308">
        <property type="entry name" value="TRM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10631">
        <property type="entry name" value="N 2 ,N 2 -DIMETHYLGUANOSINE TRNA METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10631:SF3">
        <property type="entry name" value="TRNA (GUANINE(26)-N(2))-DIMETHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02752">
        <property type="entry name" value="Arrestin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02005">
        <property type="entry name" value="TRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01017">
        <property type="entry name" value="Arrestin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51626">
        <property type="entry name" value="SAM_MT_TRM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 10" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 10" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 10" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="1 10" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="Arrestin C-terminal-like" evidence="12">
        <location>
            <begin position="561"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="459"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="459"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="474"/>
            <end position="485"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00039099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00051897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00074266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM01017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAG5106258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="745" mass="82958" checksum="E877CCEF64A9C42E" modified="2022-05-25" version="1">MENSIKVSGGKVNEGKAEILVEETNVFYNPVQEFNRDLSIAVLSLFAKDKYEENCKKAGDNKDGAEKTDGDTVDIKPGDKTENGISVLEALSATGLRSIRYAKEVPYLKQIIANDISAKAAESIKKNIIHNKVEHLVTASQQDATMLMYQSRQTRFDAIDLDPYGCPSIFLDSAVQSVSNGGLLLITATDMAVLAGNSPETCYVKYGATSLKSKACHELALRILLQHIAAHAGRYGRYIEPLLSVSVDFYIRVFVRVFTSQKKCKDNTTKLGMVYQCTGCETMTLGPLGIRVNKAHKLPQSPPVGQLLLNSIDENHAELGTVKRLEGVLNVVDEELETPLYYVLDRLMSIVRCDTPSMIKFRSAILNAGYKVSISHAHKLSIKTDAPMEVIWDIVRAWEKIHPAKRDRLDKNSAALAILSAEPTTADVSFDLHPSANPMSRQKHMTRFQLNPTSYWGPGTKSTTMINSNETTAKRLKNQNKRSKKSMNEQEDNQAIDSPIIESDSPPNYLSGTEPIDGVLLVDQDYVNSGRRIWGQLVCNFRYGREEDEPCTVVRKDFLLSPGELELEVTLDKQIYHHGESIAVNISVRNNSNKVVKKIKALVQQGIDVVIFQNGQFRTVIDAIEMQDGCPISPGSTLQKVIYLKPELENNKHRRGIALDGRLKREEDELASSTLITTPDVRDSFGIIVSYAVKVKLYLGALGGELCAELPFILMRQKSNERVKLMPSENFNVEELQSDEKCVKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HQA9</accession>
    <name>A0A8J2HQA9_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Similar to FLNB: Filamin-B (Homo sapiens)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HICCMSTLAB_LOCUS11120</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the filamin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5102649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="18740at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd21227">
        <property type="entry name" value="CH_jitterbug-like_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21229">
        <property type="entry name" value="CH_jitterbug-like_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21185">
        <property type="entry name" value="CH_jitterbug-like_rpt3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:001473">
        <property type="entry name" value="Jitterbug, isoform C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000068">
        <property type="entry name" value="Putative Filamin-A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000078">
        <property type="entry name" value="Putative Filamin-A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001589">
        <property type="entry name" value="Actinin_actin-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044801">
        <property type="entry name" value="Filamin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017868">
        <property type="entry name" value="Filamin/ABP280_repeat-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001298">
        <property type="entry name" value="Filamin/ABP280_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38537">
        <property type="entry name" value="JITTERBUG, ISOFORM N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38537:SF13">
        <property type="entry name" value="JITTERBUG, ISOFORM N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00630">
        <property type="entry name" value="Filamin"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SMART" id="SM00033">
        <property type="entry name" value="CH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00557">
        <property type="entry name" value="IG_FLMN"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00019">
        <property type="entry name" value="ACTININ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50194">
        <property type="entry name" value="FILAMIN_REPEAT"/>
        <property type="match status" value="9"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="6">
        <location>
            <begin position="39"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="Calponin-homology (CH)" evidence="6">
        <location>
            <begin position="154"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="repeat" description="Filamin" evidence="4">
        <location>
            <begin position="359"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="repeat" description="Filamin" evidence="4">
        <location>
            <begin position="458"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="repeat" description="Filamin" evidence="4">
        <location>
            <begin position="548"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="repeat" description="Filamin" evidence="4">
        <location>
            <begin position="1044"/>
            <end position="1155"/>
        </location>
    </feature>
    <feature type="repeat" description="Filamin" evidence="4">
        <location>
            <begin position="1153"/>
            <end position="1229"/>
        </location>
    </feature>
    <feature type="repeat" description="Filamin" evidence="4">
        <location>
            <begin position="1225"/>
            <end position="1336"/>
        </location>
    </feature>
    <feature type="repeat" description="Filamin" evidence="4">
        <location>
            <begin position="1334"/>
            <end position="1427"/>
        </location>
    </feature>
    <feature type="repeat" description="Filamin" evidence="4">
        <location>
            <begin position="1436"/>
            <end position="1516"/>
        </location>
    </feature>
    <feature type="repeat" description="Filamin" evidence="4">
        <location>
            <begin position="1514"/>
            <end position="1608"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="629"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="703"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="762"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="921"/>
            <end position="953"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="649"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="676"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="703"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="764"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="781"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="820"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="921"/>
            <end position="939"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAG5102649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="1631" mass="178169" checksum="03DADA0B38D157A2" modified="2022-05-25" version="1" fragment="single">MQSMEQLRPEELVGLVARSAEGTAAKGMPIKGNEDLWVEIQANTFRNWVNEHLKHAGDAGGGPVLDLAEDFRDGTRLCALVEVLTKRRLPRWNPRPANQHHHLENVSTALQAIEADGVKLVNIGNVDIVNGNLKLILGLIWSLIVRYQIGKSKFPPRKLMLAWLKAVLPECRVNNFTTDWNSGVYLSALLDYCKPGLFPHWRQLDRTDSVYNCRKAMEISKREFDIPVVLEPEYLASPYLDELSGMTYLSYFMKEGSPGFYATLRWVNSQLTHAPVRNFTTDWNDGRALCSIVRNLGGPAPTYDKIKTDPKYWESNLQQGIDGAKKLGVEPILKAKDMADQNVEHLGVMAYAAHFQWVKPRPQASEQLAVHVDSTSARVQQPAIFRLEMLSKEVHPREVRGEIISPSGKIECRLTWNGTHGKGTFVPTEVGMHKLMVYNDGELVNGCPYYFRVLPPLTKIKSPGMEPCAIGSIVEVLVNSYGTSHDGIDVTAWSPTNRSLPCPVKENSGVHTATFQPDETGEWSIAITHKGTHIQGGPFTCFVFDPNGIKLMDTEGAIPGQPFSFIVDATGTGGLGDVNIDIVHDKQSVPFRMEDIGRMRYRVFMVPREAGKYRVYLYFNGSDVRGSPISIRVGSHKSRRSKEASSSYERSKVSSLEKRMNGLNVTDGQKRHSPVYKSSSQSPTQNYRDYHHQSYKSNYVTENSNSYQVPSPLQASRSPVQNSSPSLIKESREIYSSTTFNRSRSPVNVAQSPSLIKESKDVYASSSLKRSRSPNLRDSHTTASSSVIKESKDIYQSSTLNRSRSPAVSPINRSFSPRVNGKDLGRRRGSADSGVIDTSSNVRVSSTLGGTPRRDSWDAIAKTKAMLSYGSLESLANLANSGTEHTNFVNEGYRNGYNNYSSTTNVERTVENSKNYTTRFTSDYRSSSPKYNGNHTMENGRSHTHGILKNRNNNYYKSTDTTDIIHERLINNEEFMNTTERRKGCLASGTALDVLPLHKPASFTLDPSVDGSKAIVTVTGPRGKQISYKKSTLRGYTYTITAEEVGEHTIQVTVNGQHIKGSPFRSQAYDAAAIHVDNVPDGVVNQPVEFEIDGSRAGSGNLEILVNGGHVTSFVKALGSHRFLASFVPHEAVTHLVEMTFNGETVPGSPWRVNVMPGPKMSVLGDSVRLVPAGTPALFELSALGFTSKEIDVQIITPSKRHITARVDEEPGRTGEFRVEFTPTEVGSHLVEVSVAGQKLPAGPLIAKVYNSSLIQVTDVPSAVVGHACQFRVDASAAGEGQLEISINEGEVPNHVQVVGGGRCLVSFTPESAKPHYIDIKFNGEAVPGCPFVCNVSDTSRVILSLNHLELIPVDQPANFHMAVDGSGSAELAVSVRGPTIELPVKVTGNIHSGFTAEFTPRDVGVHSISVEYNGHPVNGTPFLAKAFNADKVLIGPVARGSVGQPTHFTVDASQAGEGNLEITISARGQNIPTQVTPQGNARFSVSFVPFEACEHVINIAFNKRTVPGCPIVTRVGGDSHVTVSGQALSSAGLGRQSHLTVSNVAGSLEDLEVNVEGPNGQAVPAQVTDNKDTTCTVAFTPRVVGEHRIAVSHRNIPVVGSPFSCKVYDVTAIKVKDAKRGVIGMPVTFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HR24</accession>
    <name>A0A8J2HR24_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Similar to PTBP2: Polypyrimidine tract-binding protein 2 (Homo sapiens)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HICCMSTLAB_LOCUS11651</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5103721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HR24"/>
    <dbReference type="OrthoDB" id="296632at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12425">
        <property type="entry name" value="RRM4_PTBP1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000036">
        <property type="entry name" value="polypyrimidine tract-binding protein 1 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055204">
        <property type="entry name" value="HNRNPL_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15592">
        <property type="entry name" value="MATRIN 3/NUCLEAR PROTEIN 220-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22976">
        <property type="entry name" value="RRM_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="179"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="143"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAG5103721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="256" mass="27387" checksum="C1EBF4E5BADA0EAD" modified="2022-05-25" version="1">MKIKYSHTLDGQNIYNSCCTLRIDFSKMQSLNVKYNNDKSRDYTNPTLPTGDPNLDAASLALGVESITGAPSVLASPFAAMHGLPSPLGGPYGNGVAPGAGLAGLGGFSLGAGALGVRVPGNPQISSVLLVTNLNEETVQLPKEGQPDAGLTKDYTNSPLHRFKKPGSKNYQNIYPPSATLHLSNIPATVTEDEIKDAFTSNGFTVKAFKFFPKDRKMALIQMPSMDDAVAALIKMHNYQLSESNHLRVSFSKSNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HR46</accession>
    <name>A0A8J2HR46_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Similar to Nphs1: Nephrin (Rattus norvegicus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HICCMSTLAB_LOCUS12834</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5107619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HR46"/>
    <dbReference type="OrthoDB" id="6250964at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23278">
        <property type="entry name" value="SIDESTEP PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23278:SF4">
        <property type="entry name" value="SIDESTEP, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="300"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="3">
        <location>
            <begin position="56"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="357"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG5107619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="383" mass="42899" checksum="C6860068DE2B86F8" modified="2022-05-25" version="1" fragment="single">DTRLEHDISRGILIAANTLTLRVLSLQYSGEYSCYAKNDVGEARSQPLFIYMKYAPRCKVGFEYNNVVALLDETVKLRCEVEATPNDGVRFSWTFNGTKGDVLPIQNSRPRNHERTSTLEYTILIESDYGTLGCWASNSVGRQRTPCIFNIVPAKAPQSPIDCTLHNESSALEVNCIPGSDGGLPQHFLLEVRGSMVETQLLQTSQTLQTPQSDQGKMGEAPPIYRTENLRPTFQLNDLEPGYDYTLAVYAINKHGRSQPKLFRNVRIYGTDLERNMEVSGEFVIDNKQNIIPRSNLENFLITVGVIGGAAAILVGIGIIIGVIICRKRVHTPRAEYIEDLTTPTYVSAQRIEPRVKYGSDRRRSQRTSLYMEESKNGKLSAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HRP2</accession>
    <name>A0A8J2HRP2_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Similar to Swip-1: EF-hand domain-containing protein D2 homolog (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HICCMSTLAB_LOCUS13428</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5108792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HRP2"/>
    <dbReference type="OrthoDB" id="6572480at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000112">
        <property type="entry name" value="EF-hand domain family, member D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040365">
        <property type="entry name" value="EFHD1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13025">
        <property type="entry name" value="EF-HAND DOMAIN-CONTAINING PROTEIN D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13025:SF6">
        <property type="entry name" value="EF-HAND DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="5">
        <location>
            <begin position="21"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="5">
        <location>
            <begin position="47"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="123"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAG5108792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="160" mass="18478" checksum="3B6F7448D90900F6" modified="2022-05-25" version="1">MYKQDKVALKLLAKVTGFVQNTFDDGRDGFLDLAELKRMMEVLGAPQTHLGLKAMIKEVDEDDDGRISFREFLLIYRKARAGELEQDSGLGQLARLTEVNVDEVGVTGAKNFFEAKIEELRKSSKFENEIRMEQEERKREEEDKAMRRAQFRQKAAIFNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HS18</accession>
    <name>A0A8J2HS18_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">DNA-directed RNA polymerase subunit</fullName>
            <ecNumber evidence="14">2.7.7.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">HICCMSTLAB_LOCUS12271</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="13">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Largest and catalytic core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Forms the polymerase active center together with the second largest subunit. A single-stranded DNA template strand of the promoter is positioned within the central active site cleft of Pol III. A bridging helix emanates from RPC1 and crosses the cleft near the catalytic site and is thought to promote translocation of Pol III by acting as a ratchet that moves the RNA-DNA hybrid through the active site by switching from straight to bent conformations at each step of nucleotide addition.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the RNA polymerase III (Pol III) complex consisting of 17 subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the RNA polymerase beta' chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="14"/>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5106460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="270392at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02736">
        <property type="entry name" value="RNAP_III_Rpc1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02583">
        <property type="entry name" value="RNAP_III_RPC1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.40.20:FF:000019">
        <property type="entry name" value="DNA-directed RNA polymerase II subunit RPB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.132.30:FF:000001">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.390:FF:000004">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.274.100:FF:000003">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.390">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.50.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.180">
        <property type="entry name" value="RNA polymerase ii"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.860.120">
        <property type="entry name" value="RNA polymerase II, clamp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.274.100">
        <property type="entry name" value="RNA polymerase Rpb1, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019399">
        <property type="entry name" value="Parkin_co-regulated_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000722">
        <property type="entry name" value="RNA_pol_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006592">
        <property type="entry name" value="RNA_pol_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007080">
        <property type="entry name" value="RNA_pol_Rpb1_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007066">
        <property type="entry name" value="RNA_pol_Rpb1_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042102">
        <property type="entry name" value="RNA_pol_Rpb1_3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007083">
        <property type="entry name" value="RNA_pol_Rpb1_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007081">
        <property type="entry name" value="RNA_pol_Rpb1_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044893">
        <property type="entry name" value="RNA_pol_Rpb1_clamp_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035698">
        <property type="entry name" value="RNAP_III_Rpc1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035697">
        <property type="entry name" value="RNAP_III_RPC1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038120">
        <property type="entry name" value="Rpb1_funnel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015700">
        <property type="entry name" value="RPC1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006336">
        <property type="entry name" value="PRK08566.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48446">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA' N-TERMINAL SECTION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48446:SF1">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA' N-TERMINAL SECTION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10274">
        <property type="entry name" value="ParcG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04997">
        <property type="entry name" value="RNA_pol_Rpb1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00623">
        <property type="entry name" value="RNA_pol_Rpb1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04983">
        <property type="entry name" value="RNA_pol_Rpb1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05000">
        <property type="entry name" value="RNA_pol_Rpb1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04998">
        <property type="entry name" value="RNA_pol_Rpb1_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00663">
        <property type="entry name" value="RPOLA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64484">
        <property type="entry name" value="beta and beta-prime subunits of DNA dependent RNA-polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 14 16" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 14" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 14" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="RNA polymerase N-terminal" evidence="15">
        <location>
            <begin position="232"/>
            <end position="539"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00058108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU004279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CAG5106460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="1568" mass="176233" checksum="F404A46F35E68CCD" modified="2022-05-25" version="1">MVKEQFRETHLAKKISHITFAINSHHDIARQAHVNVVCHPLYSEQDHTPVPYSALDPRLGLCTKQGECKTCNLPYLDCIGHFGYINLEFPVFHYGYFKSIVNILQSICKRVSNPNLGYLERKALRSQILKKVKKKSVCPYCGDLNGVVKKAGLLKIVHQKFQKSKKSDLQVMANELVEYETAMQSNKELEGTLKTSHLAYILNPLEVLNLFERIPVNDVPFLMMNPNTGMPKDLLITRIPVPPICIRPSVKSDFKSGTNEDNLTMRLSQIVLLNDQIRQSRERGMKMLQYNDVLEFIQIHTAFYINSQVTGIPLDKQPTNPGRGLVQRLKGKQGRFRGNLSGKRANFTARTVISPDPNLRIEQVGIPIHVAKILTYPERVCTANIEKMRQLVLNGANKHPGANHVKIMKSKEVTSIFLGFANRAEIARNLKIGDIVERHLRDDDLVLFNRQPSLHKLSIMAHKAKVLEHRTFRFNECVCNPYNADFDGDEMNVHLPQTEEARAEALVLMGNKSNLVTPRNGELLIAATQDFLTGGFLLTQKDTFLNKSEAWQLAACLLAGFDSNMQIDMPEPAILKPRPLWTGKQIFSLILRPNKSCKILANLRTKGKNYTDQEELCANDSFVVIRNSELLAGSMDKNTLGSGSKQNIFYVLLRDWSEDAATTAMWRLSRMASIYLMNRGFSIGIGDVTPGQRLLKAKQDLLEHGYKVCEDLIKQMESGELKLAPGCSMEETLESKILKELSDIREKAGKACLRELHRSNSPLIMTLSGSKGSYINISQMIACVGQQAISGHRVPNGFEDRALPHFDRHSKIPAAKGFVSNSFYSGLTPTEFVFHTMGGREGLVDTAVKTAETGYMQRRLMKNLEDLGLHYDKTVRNSAGGIVQFEYGGDSMDPTYMEGKDCPVDYKRVLDHVRAKVPDKNGDALSGSEVVSAASLLLDKDDFKCLSEEFKNELTAFLTTVARKISMLRKKYPPSIKAAQQLERITLTQVSEFMFTCKEKFMRAKIEPGTAVGALAAQSIGEPGTQMTLKTFHFAGVASMNITQGVPRIKEIINASSKISTPIITAYLTEDENEDFARRVKGRIEKTTLGEVTEYFEEVILPDSCFFLVKLDIGRIKLLMLEVDVNSIKYSLETAKLKKHFKEVRVHSSSILTIVPVSNVKQSMSHSLNILKEAVPKVIIKGMPSVSRAIIHIDEQAVESGSNEEERNVTKKKKKFKLFVEGDNLREVMATPGIFNTKTTSNNTMEVFKTLGIEAARSTIMTEIKLVMENHGMSIDRRHSMLVADLMTSYGEVNGITRQGLAKMKESVLNLASFESTADHLFDAAYYGQTDVISGVSEAIIMGIPAPIGTGIFKLLHKNDKEEPKKRDLLFSDPEFHKTSPSNFRKFYERGLFPISIENDSSSITWKVNIEELDFHHYLPMFFDGLTETEHPYKFLVEQGISDMLEHGGPKILPVVPQLIIPIKNALNTKVPEIICMTMRALQRLVRSADCVGESLVPYFRQILPILNLLKDRNGMNLGEGIDYSQQRGENLADLIQETLEVLERYGGEDAFINIKYMVPTYESCMMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HSU4</accession>
    <name>A0A8J2HSU4_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Fatty acyl-CoA reductase</fullName>
            <ecNumber evidence="4">1.2.1.84</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HICCMSTLAB_LOCUS12695</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the reduction of fatty acyl-CoA to fatty alcohols.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a long-chain fatty acyl-CoA + 2 NADPH + 2 H(+) = a long-chain primary fatty alcohol + 2 NADP(+) + CoA</text>
            <dbReference type="Rhea" id="RHEA:52716"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:77396"/>
            <dbReference type="ChEBI" id="CHEBI:83139"/>
            <dbReference type="EC" id="1.2.1.84"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the fatty acyl-CoA reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.84" evidence="4"/>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5107330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HSU4"/>
    <dbReference type="OrthoDB" id="429813at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102965">
        <property type="term" value="F:alcohol-forming long-chain fatty acyl-CoA reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080019">
        <property type="term" value="F:alcohol-forming very long-chain fatty acyl-CoA reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035336">
        <property type="term" value="P:long-chain fatty-acyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05236">
        <property type="entry name" value="FAR-N_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09071">
        <property type="entry name" value="FAR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026055">
        <property type="entry name" value="FAR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033640">
        <property type="entry name" value="FAR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013120">
        <property type="entry name" value="FAR_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11011:SF60">
        <property type="entry name" value="FATTY ACYL-COA REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11011">
        <property type="entry name" value="MALE STERILITY PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07993">
        <property type="entry name" value="NAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03015">
        <property type="entry name" value="Sterile"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="3 4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="372"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="489"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="domain" description="Thioester reductase (TE)" evidence="6">
        <location>
            <begin position="35"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="domain" description="Fatty acyl-CoA reductase C-terminal" evidence="5">
        <location>
            <begin position="382"/>
            <end position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAG5107330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="529" mass="61663" checksum="B5DBADE3ED1CB341" modified="2022-05-25" version="1">MEDIYRRISNEDDFGEDDTEISEIQQFFKGQTILLTGCTGFLGKCFVEKILRGCPEIKKLILVVRSRKLSAKERMKKYFQNELFDRLRRYRPNFESRVLVVEGNLEEENLGISEEDRKIITDNVTMMYHNASNVKFITRVSESLKCNVLGTKYMIDLAKECKKLRCFCYISTAYSHSYKKKIEEVCYPSPASIKMVQDLIYADEIAKHGIPQATVDETIKPWVNIYTFGKSIAESLVEDYAKEASFPCIIYRPSQIISTYMEPFPGWCGNWNGPALPFLGYGLGIVHLNNTNRAVQDHVPADMCANSILAITWDTVTNRKEIGKVHVFNYASSTIKPVTLREFELHAVPRGREGPSLKTLAPNFMIEVPCQFVFWVLHFFVHFIPALVADIALLAMLQKPQALAVFYKITINMPTIRYWSSSDWRITVKETEKVWDRMNRRDKILFYNDIRTIDWWISGYSYWFGLKKFVLKEPMDHARGRFRYNLMKAIWIVGIGLIVSYFAYQLFVYWLTLISPLTQFIKNEYICRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HU02</accession>
    <name>A0A8J2HU02_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS13544</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5108908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HU02"/>
    <dbReference type="OrthoDB" id="10296363at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5108908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="257" mass="30195" checksum="849052593D1B4AD1" modified="2022-05-25" version="1">MSKQECCFGASNSEVAKKYIEFYNKITSVDEESSNEDEKLTMENIVELIVSNKKIGDDNNYNKTCTQPSTSKQYTEDEVYQVGDSNKVEDNIEGVQTALLKKDKKKSLCKQQPIQQRSDEHDYEQLHQRLLQFIHKDKKLYDETDPDPLYWAFMGSDYSYVADILIEATSKDLCDYVLAKKKGQNPEAIRIKLRINEAHKLLLILHDCYNLIYNRLRKFQKQRTHRGVFLSYLRINNLDYETKIELIQNQIEDLNKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MCU0</accession>
    <name>A0A8J2MCU0_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS3368</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5081746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MCU0"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5081746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="83" mass="9861" checksum="BD3A3796E77CBB3D" modified="2022-05-25" version="1" fragment="single">LGKNFVGVQNSIWIHQAFDFLHQLDRRLVFAVAEILRFFKSDPMLGAHTPTLLRYVLKEERLKLRLDLWVVLGCCHYHMCQYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MDI1</accession>
    <name>A0A8J2MDI1_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">GDP-mannose 4,6-dehydratase</fullName>
            <ecNumber evidence="4">4.2.1.47</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">GDP-D-mannose dehydratase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HICCMSTLAB_LOCUS4141</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Nucleotide-sugar biosynthesis; GDP-L-fucose biosynthesis via de novo pathway; GDP-L-fucose from GDP-alpha-D-mannose: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the NAD(P)-dependent epimerase/dehydratase family. GDP-mannose 4,6-dehydratase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.47" evidence="4"/>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5084568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MDI1"/>
    <dbReference type="OrthoDB" id="10253554at2759"/>
    <dbReference type="UniPathway" id="UPA00128">
        <property type="reaction ID" value="UER00190"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008446">
        <property type="term" value="F:GDP-mannose 4,6-dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042351">
        <property type="term" value="P:'de novo' GDP-L-fucose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd05260">
        <property type="entry name" value="GDP_MD_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000924">
        <property type="entry name" value="GDP-mannose 4,6 dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00955">
        <property type="entry name" value="GDP_Man_dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006368">
        <property type="entry name" value="GDP_Man_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01472">
        <property type="entry name" value="gmd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43715:SF1">
        <property type="entry name" value="GDP-MANNOSE 4,6 DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43715">
        <property type="entry name" value="GDP-MANNOSE 4,6-DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16363">
        <property type="entry name" value="GDP_Man_Dehyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-binding" evidence="7">
        <location>
            <begin position="10"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00031085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF16363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG5084568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="356" mass="40228" checksum="2845A66B28F0588C" modified="2022-05-25" version="1">MATGEKRIALITGITGQDGSYLAEFLLEKEYEVHGIIRRASSFNTTRIQHLYADPKSHKQEKMKLHWGDMTDSSSLIKVIAAVQPTEIYNLAAQSHVKVSFELSEYTGEVDAIGTVRLLDAIRTCGLEKKVKFYQASTSELYGGRDASAPQNESTPFYPRSPYACAKIYSYWIVINYREAYGLYACNGILFNHESPRRGENFVTRKITRTIAKIYLGAQDVLELGNLNAKRDWGHAKDYVKAMWMMLQQENPEDYVIATGESHSVREFVELAFQHVNINIIWEGTGVDEVGRDKNSGKVLVRVNPRYFRPTEVGMLLGDASKAKMKLGWEPSVSFKELVEDMMNADLALMKKDPTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MFM8</accession>
    <name>A0A8J2MFM8_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Similar to lig: Protein lingerer (Aedes aegypti)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HICCMSTLAB_LOCUS4851</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5088453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MFM8"/>
    <dbReference type="OrthoDB" id="5918007at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14277">
        <property type="entry name" value="UBA_UBP2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051833">
        <property type="entry name" value="TC-DDR_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022166">
        <property type="entry name" value="UBAP2/Lig"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16308:SF13">
        <property type="entry name" value="PROTEIN LINGERER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16308">
        <property type="entry name" value="UBIQUITIN ASSOCIATED PROTEIN 2-LIKE/LINGERER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12478">
        <property type="entry name" value="UBAP2-Lig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="107"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="323"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="380"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="517"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="547"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="702"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1041"/>
            <end position="1113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="25"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="132"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="161"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="187"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="236"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="326"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="380"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="517"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="563"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="608"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="702"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="728"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="776"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1069"/>
            <end position="1080"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1082"/>
            <end position="1113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAG5088453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="1113" mass="116462" checksum="4F4D2DF2021A3D8B" modified="2022-05-25" version="1">MSSGNKSLVSSGGRGTNKSKSQQHGKSDQHHSKTSDTTKHEKGQSNKDQTKHAQIIDTRPGGVEDPGLKDQIKQIMEVTRKSEDEVIMALHDSDWDFDRAVNDLIEGVSSEWEVKKKKPRQPSGSKQGADQSGDHDESGGGDWEERRHQRGNGPPRMRGRANHDNRGRGRENKENERNMEDNVREGAYGGSRRGRGGPGRSGRGGRGGGRGLGPRTFANRGDSSGPHSFNRPIDTWTGSEEQQQSSQDAKIASDPWNNLEPSEDWESEYTGSLADTKVFTPSTSINDQAGMEESNIASETVVQSNVQPGNLSGLPQEDLSKMSDVQTMQSQPSMIQSQPPQSQQALGMPTQMQLSQQSNTLTAAQSQYLTQLTQQTSENYKSANQSAFSSMTISGQAQRQTKQRPRVPPPSKIPSSAVEMPADTVNSNIGFLDVQFGALEFGSDTTTLDGTANDKYNSSSTNISGIDVSSNVTASGIANSAASSNTLDIDTAQQGGSYNASSQMIASPNNTGVTYGNASSNSATYQPQKTSYQGSNAATSNNYNAYSSTGGQSVQSSFPTAPGGNTNSYTTTTSVTQSGYSGSYPQSNASTFSQASPSAPSSTGTSGYNQTTSSNQGYQSSSGFVPTTTAQYQGQQSASAGVNSNSGYQASSYQGTSSFQSTSQAYQPSATTFTSPMTQANSSAYQSAAHSVYASAYGNYNTQSQTPSHTHTKLSTTSGKDSQYDNVTTSSSSLATTSAPALGLSSTSVNSSQTKVSSSNAVPKSTSSGSTGTGTSGSITGASSAGGTASSMTPMLSHQYIMSQGVPYPTFQQPMYSYEDLQLMQQRIPHMVILCLAFLTNLQPTTGYYDAALGYQTTGPATSLGGGRSDALSGVQGVQGVQGVQGAYTSISDGRFARNDSNASPVPSTMSQQVTTATQHQQPMMNPALPPGYAYFTYGATAGNAGTNSGAYSAKPGSYGSGYGGGASYDTLTNTGPTGDYKGAGSGYTGTQTGKTGTSTGNNNSGASSATDIGATMYAKSHVALSKVNSYDKQTFHSATPPPFSLTSSQTAGMPGGYGAPHLFISTMPHTQHLHQPLHQDGGSSSGQRSNTNSQNKAQAKPGYSSNYWTAGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MJH3</accession>
    <name>A0A8J2MJH3_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein FMC1 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS4538</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FMC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5087537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MJH3"/>
    <dbReference type="OrthoDB" id="551431at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037667">
        <property type="entry name" value="FMC1_homologue"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31716">
        <property type="entry name" value="PROTEIN FMC1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31716:SF1">
        <property type="entry name" value="PROTEIN FMC1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13233">
        <property type="entry name" value="Complex1_LYR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5087537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="116" mass="13282" checksum="FB357F98D66D5D95" modified="2022-05-25" version="1" fragment="single">LKMNSNLQLIRSLLREIRLTSSESKIKDNIVVRYIMEQARAHKETSETLCKAREELLHLATTYNCYLSSLRTYNEINTQYAGAGERTVRETADLVGFKLPHDPNIDLFMSMLCGSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MJN3</accession>
    <name>A0A8J2MJN3_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Similar to Nomo1: Nodal modulator 1 (Mus musculus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">HICCMSTLAB_LOCUS7908</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5095838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MJN3"/>
    <dbReference type="OrthoDB" id="10263633at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1120">
        <property type="entry name" value="Carboxypeptidase-like, regulatory domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013784">
        <property type="entry name" value="Carb-bd-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055075">
        <property type="entry name" value="NOMO-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055074">
        <property type="entry name" value="NOMO1-3_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055073">
        <property type="entry name" value="NOMO1-like_9th"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056191">
        <property type="entry name" value="NOMO_12th"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056189">
        <property type="entry name" value="NOMO_3rd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056190">
        <property type="entry name" value="NOMO_5th"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056319">
        <property type="entry name" value="NOMO_7th"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051417">
        <property type="entry name" value="SDr/BOS_complex"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23303:SF14">
        <property type="entry name" value="BOS COMPLEX SUBUNIT NOMO1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23303">
        <property type="entry name" value="CARBOXYPEPTIDASE REGULATORY REGION-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13620">
        <property type="entry name" value="CarboxypepD_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23141">
        <property type="entry name" value="Ig_NOMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22898">
        <property type="entry name" value="NOMO1-like_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22904">
        <property type="entry name" value="NOMO1-like_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22902">
        <property type="entry name" value="NOMO1-like_9th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23192">
        <property type="entry name" value="NOMO_12th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23193">
        <property type="entry name" value="NOMO_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23194">
        <property type="entry name" value="NOMO_5th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="Carboxypeptidase regulatory domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49452">
        <property type="entry name" value="Starch-binding domain-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035159063" evidence="7">
        <location>
            <begin position="24"/>
            <end position="1145"/>
        </location>
    </feature>
    <feature type="domain" description="NOMO-like N-terminal beta-sandwich" evidence="8">
        <location>
            <begin position="44"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="NOMO second beta-sandwich" evidence="10">
        <location>
            <begin position="80"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="NOMO third transthyretin-like" evidence="13">
        <location>
            <begin position="214"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="domain" description="NOMO fifth transthyretin-like" evidence="14">
        <location>
            <begin position="360"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="domain" description="NOMO seventh transthyretin-like" evidence="11">
        <location>
            <begin position="536"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="domain" description="NOMO-like ninth beta-sandwich" evidence="9">
        <location>
            <begin position="698"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="domain" description="NOMO C-terminal transthyretin-like" evidence="12">
        <location>
            <begin position="955"/>
            <end position="1060"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF22898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF22902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF22904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF23141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF23192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF23193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF23194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CAG5095838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="1145" mass="126378" checksum="29E8F034B0A1C7F0" modified="2022-05-25" version="1">MSSLYKFIIYKIVFLLLSQCCVSEEILGCGGFIKSHTNIDYSKVQVEPPRGWSFEPTEVRLVVDGVNDLCSQGKDINFKFNGFGITGKVISQGSNDGPTGVTVSLYKSTNRDVVERVTTTSQGGIFSFTPIQPGKYVLVASHPHWAFEKNTVEVTVREGNTELPNNSLIIFGYDVSGQITSEPENQPVVDVSILLFGTGKIKNCKTPVISEGNAENGKALCQVKSDKNGKFKFSSVSNGDYTFVPYFANFQTKFDVEPAKVPFKVHHNDLIVSGTFKVTGFTVAGRVMMDKNTPLANARVFLSGKEVAKTNSNGAYTIDKMKAGQYSLKVEANDVQFDEQTVKISPSEHHLPDILPSSYKVCGSVTLSTKGTLHHRKIVIENAGKTFKREVETDPQTGQYCLYLVPDNYQVSVIVTAEEKTKGLQFFPIQQTIEVSSKTISNINFLQLKATLLGSVACLKNSDCSKASVTLKVLDGVTVQTIPIKDGRYEFTEVLPGHYEVLIDTDVFCWENPSHRVLITSERAEIPVFKQTGFSVTFISSHDSAVEFIDPVKGKKVALTLPLGSTRHCVSSPGEYKFIPKSCHVYAKDSYTWDTKTQQPIILSSTEHRHRGKIISNAGVDNVKIKIESGGDSTTFGPLKYDKTGDSYRYIFEFNAHTDSTYVITPISDIMLFNPSSLKVVGSNDCHNDVATLVGNLGKIVSGKISPALEGVTIQIYGKDKSSPVHTLVTQKDGAYRIGPLDGTIEYSVTAEKVGYAISGPDANGVFSAHKLAEIIVEVTDQADDSSLQGVLLSLSGGQSYRKNSITPEQGQLSFNSLSPGEYYLRPMMKEYRFDPPSKMITVTEGATLRVKLSGNRVAFSAYGVVTSLNGEPEPGLIVEAQGQGDCSNLQEEATTEENGNFRIRGLQPTCMYIIRLKPNTEVNAHIHRVSPSSIAAQATEDISKLRFVAFHPISRTDLAVRVFSDPPEHYRTLKVKLCREDQPDSPIHTAKIDPQQANKFTSHSNPGFLIHLPSLQSNGRKYFVQLDTSLSSSMYKYRIVPNYFEANTSFKAITLNFNAERKIDQGEMSQSSILALPFIMMVALAFLNRDKLWSWLNSAVDYWSKPTLVSRSSQPVAPIDPRADDIIVEQIMNINKRKTKPRKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MK19</accession>
    <name>A0A8J2MK19_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS3184</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5081064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MK19"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="110"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="158"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5081064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="201" mass="20426" checksum="B990368CA934431C" modified="2022-05-25" version="1">MYRVKNSVVGVSAVEVLITPIVAEFGVVLIVSNVEIGAPVVDSIGVVRAGNDSGVKVLNTPSVIDSNGVVEAINDSVVISGVKVVVVLSSVNSFGAVDTKNDSVVVSVGVVVLLISVSVVGASVIISGIKVVVVLSVVDSIGVVDRKNDSVVISGVKVPISSFVVGVVVILISVSVVGASKENNQMIKSSKQNPDYTTDTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2ML50</accession>
    <name>A0A8J2ML50_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS6746</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5093319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2ML50"/>
    <dbReference type="OrthoDB" id="10285341at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5093319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="115" mass="15149" checksum="B9DBBBAB82DDE19B" modified="2022-05-25" version="1">MYYPYEYLWYHDLRRWTYAEDDHLIYLRTRHYDVRFNTTWRDVKLFNLNWWQDIANDAVFRRRNKDVYDCYDRFCKLVDKFMELRVMDRKERPYWEHYKMLRWFFHDCRNKFPDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MLE2</accession>
    <name>A0A8J2MLE2_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS6286</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5092654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MLE2"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5092654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="127" mass="14400" checksum="478896549A5D19BA" modified="2022-05-25" version="1">MILNILGDEQYRAGGSSSGSPPASLLVVPQPLTVKPSHPSHLNPHLGGPHPPRKYQCKMCPQVSVIVMNYDNNYLRIYDMRLQSLLLCFYLVSCTRTLLVLMPDQIADNYDFYLFKRENSWGKCPNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MLG6</accession>
    <name>A0A8J2MLG6_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to Ccp84Ab: Cuticle protein (Anopheles gambiae)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS7091</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5093765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MLG6"/>
    <dbReference type="OrthoDB" id="10071059at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042302">
        <property type="term" value="F:structural constituent of cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031311">
        <property type="entry name" value="CHIT_BIND_RR_consensus"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000618">
        <property type="entry name" value="Insect_cuticle"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051217">
        <property type="entry name" value="Insect_Cuticle_Struc_Prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12236:SF86">
        <property type="entry name" value="CCP84AC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12236">
        <property type="entry name" value="STRUCTURAL CONTITUENT OF CUTICLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00379">
        <property type="entry name" value="Chitin_bind_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00947">
        <property type="entry name" value="CUTICLE"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00233">
        <property type="entry name" value="CHIT_BIND_RR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51155">
        <property type="entry name" value="CHIT_BIND_RR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0193">Cuticle</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5093765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="349" mass="36579" checksum="7311126400C0C669" modified="2022-05-25" version="1">MVHALDTTREPSPPICRLGVVSVPLLAQFPTHTLLEPGGHESGDYRSLIASFSVLTPHPRISDIIHSTHSDQQINRSTTSIMAFKFVTLFALLAAANAGFIPAHQPLAYAAAPVLAKTINAEDDPHPQYNFNYDVQDATTGDFKSQYESRDGDSVQGSYSLLESDGTRRTVDYTADGINGFNAVVRKEPAQVAVKAVAPAALAVKAAPVAYAAPAAYATHYAAPAAYTTHYATPAVAKLAAPVAYAAPAAIATHPVAKVAAYSAPAAYTTHYSQPLAYTTHYANPAIAKVAAPVSYAAPAAYAAHYAAPATYATHYAAPAAYAKVAAPLAYHAPAAYTTYSAPAALYHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MLX3</accession>
    <name>A0A8J2MLX3_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="13">RhoGEF and PH domain-containing protein 4 (Homo sapiens)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HICCMSTLAB_LOCUS6912</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5093559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MLX3"/>
    <dbReference type="OrthoDB" id="245697at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007010">
        <property type="term" value="P:cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046847">
        <property type="term" value="P:filopodium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00065">
        <property type="entry name" value="FYVE_like_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13388">
        <property type="entry name" value="PH1_FGD1-4_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00160">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051092">
        <property type="entry name" value="FYVE_RhoGEF_PH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055251">
        <property type="entry name" value="SOS1_NGEF_PH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000306">
        <property type="entry name" value="Znf_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12673:SF241">
        <property type="entry name" value="DH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12673">
        <property type="entry name" value="FACIOGENITAL DYSPLASIA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01363">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22697">
        <property type="entry name" value="SOS1_NGEF_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00064">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DH" evidence="11">
        <location>
            <begin position="239"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="10">
        <location>
            <begin position="456"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="domain" description="FYVE-type" evidence="12">
        <location>
            <begin position="575"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="10">
        <location>
            <begin position="657"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="18"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="186"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="31"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="44"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="61"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAG5093559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="779" mass="89321" checksum="2A8E18C5F50D5173" modified="2022-05-25" version="1">MQRGQLKDLSSWMARLLPEPFDKTDTLKMFSSKSSTSTSTFYTELEDEEEATDNNEDSLKAQEQVQQLNKSNHNNLRDSQSLERQSATSDDGNSQDSDSVMGSDEHQQQQQLQHKQSFTSHSFPRISFSGFPRFQSFIMSTSGSESTDSITTQETSSIVQMTHSVLEYRSSRYVTTKRSSNQYTIDSYPVSESESEEESETRSSETEFTIATDEPEENNIPSEKIITTSKDTNDVKRKRAKKVADELLATEKTYVNILHLIDQVFQFRVDQENRAHPMFPPDTVQQIFSNIKSIYKFHNDFLLPQLEDRMKIWDEDSRIGDIMKNFAPFLKMYTEYVKNFDHAMNLIHTLQQKVPRFAAIVNEIQKLDVCAKLSLTHHMLCPIQRLPRYELLLKDYLKNLTEDNPDFLDTKKALELVSTAANHSNEEMKKIAKFKKLLEIQENIYDPLDLVSATRELIKEGRIVKISARSGDHQDRHLFLFSDILLLCSIRLIPGPLYRLRAKFLIENLDVIEGDNLETANTFYLRDSNKSVELYTHSAGEKAAWLDALFQTMQEIMRRKASLKIGNEKTSLVKADDVTRCMVCEAIFSVMKRKHNCRACGIVVCSKCSNQKLLFEDNKNMRVCRLCHAALTQPLSKSPSSPPGPVPSLLHVSANAPCVLSGYLLLKTQASKPWTRRWFALHSDFVLYTFKSDSESLALTATPMPGYTLTEGNELPDYDPLSQRDRKGSFKIYHSRKCYYLQASSFEDKERWTHALSLATKAELPHPVTEEDKDTEQSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MMQ8</accession>
    <name>A0A8J2MMQ8_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Similar to WDR59: GATOR complex protein WDR59 (Homo sapiens)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HICCMSTLAB_LOCUS8270</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the WD repeat WDR59 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5096559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MMQ8"/>
    <dbReference type="OrthoDB" id="311712at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035859">
        <property type="term" value="C:Seh1-associated complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035591">
        <property type="term" value="F:signaling adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034198">
        <property type="term" value="P:cellular response to amino acid starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904263">
        <property type="term" value="P:positive regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16692">
        <property type="entry name" value="mRING-H2-C3H3C2_WDR59"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006575">
        <property type="entry name" value="RWD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049567">
        <property type="entry name" value="WDR59-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039456">
        <property type="entry name" value="WDR59_mRING-H2-C3H3C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049566">
        <property type="entry name" value="WDR59_RTC1-like_RING_Znf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46170">
        <property type="entry name" value="GATOR COMPLEX PROTEIN WDR59"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46170:SF1">
        <property type="entry name" value="GATOR COMPLEX PROTEIN WDR59"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17120">
        <property type="entry name" value="zf-RING_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50908">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 4" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="106"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="RWD" evidence="5">
        <location>
            <begin position="407"/>
            <end position="509"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAG5096559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="966" mass="109412" checksum="6B4E5FC04036659E" modified="2022-05-25" version="1">MLKRWVSDYVVTEHRDLQANTMALDTTGSYVLLAGRRFLAIKKLDDSDELDSLKKYPRQSKYEVGSAEWNPTISNYHFCAISSNTRIEILSVAGNNNQDLPIIHTLKGHNRVVSDLNWHPKEPDIIASCSIDTFIHVWDLRDSRKPSLSLSAVAGSSQVKWSPLLSYTLATAHDGDIKIWDQRKSNSPVQYIAAHLTKIHGLDWCPFQQNQIATSSQDCTVKVFDICNPRKVDSILSTNYPVWRARYTPFGESLVTIVVPPLRRGENSLLLWNIANLNTPIHTFVGHTDVVLEFQWRHPKVNSNDYELITWSKDQCLRIFKIDGFLKKLCGHDMDDATSLYTQYSEDTNLRALQSVQDLQLNDSQNDNELSYSSSQVDMQMIPNEASTNLDHDKELPSPTQPKTLQQEFSLINMNIPNIELNSMDVIERSCTVTARNKNYHVILKVNFPGNYPYSAQPTFQFCSGTTVDNTTMAKLLRVLKQTSQQRVKKNRTCLEPCLRQLIITLEQTCVPSESESNLLDYHIQSNADFLNSTTICTNYQDNYIPFPRTSGAKFCSLGILVCFGRSTFTRRSFAIKPDGSTPRSLSALGNSGNNGSYMNLYSNSYGQSGDTMSISSFYFPERQQRSSRKNVYNSSVTQNQNCYNKNYYSLVTVYDTSLLFFVNKELAEKYILNLSEIPSMCQHNANVASLLNRPDLIQAWCLSALVISPLSNPLQNLCQIQDIVLPWPLHPFGQKLVHSLIQHYVNQSDIQMAGMLSCVFSDRSESHGNSLGYLTSKSVNVSPGSSPYHTIHHADTSSEGWSVQNLKYNRSSSWSESLDDSKTFPDSLNDTGRSIRLLDENNTLLYDRYKKVYAEVLHRWRLLDGRAQILKHVSASHLDSQKDVKLQSECHLCKQTNREPQCTSCKRLTFQCIICHISVKGHSTFCLICGHGGHTQHLAAWFTNERVCPTGCGCACLQENASYQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MP67</accession>
    <name>A0A8J2MP67_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Similar to rbm5-a: RNA-binding protein 5-A (Xenopus laevis)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HICCMSTLAB_LOCUS10450</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5101377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MP67"/>
    <dbReference type="OrthoDB" id="29221at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12313">
        <property type="entry name" value="RRM1_RRM2_RBM5_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1060.10">
        <property type="entry name" value="Zinc finger, RanBP2-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055494">
        <property type="entry name" value="DUF7066"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000467">
        <property type="entry name" value="G_patch_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041591">
        <property type="entry name" value="OCRE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001876">
        <property type="entry name" value="Znf_RanBP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036443">
        <property type="entry name" value="Znf_RanBP2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13948:SF3">
        <property type="entry name" value="FI21118P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13948">
        <property type="entry name" value="RNA-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23217">
        <property type="entry name" value="DUF7066"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01585">
        <property type="entry name" value="G-patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17780">
        <property type="entry name" value="OCRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00443">
        <property type="entry name" value="G_patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00547">
        <property type="entry name" value="ZnF_RBZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90209">
        <property type="entry name" value="Ran binding protein zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50174">
        <property type="entry name" value="G_PATCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01358">
        <property type="entry name" value="ZF_RANBP2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50199">
        <property type="entry name" value="ZF_RANBP2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RanBP2-type" evidence="12">
        <location>
            <begin position="279"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="739"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="domain" description="G-patch" evidence="11">
        <location>
            <begin position="846"/>
            <end position="892"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="422"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="521"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="774"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="16"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="38"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="83"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="98"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="424"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="788"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="810"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="825"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="838"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="920"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAG5101377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="920" mass="105625" checksum="DD0E294F79A76AA8" modified="2022-05-25" version="1" fragment="single">MYSNIDPWEPGYGPPSDRRGHNNSEYEYRNSKSPPEFGELREIEHRERTHRSPDYRNSHRRERDRDHDRLRDKRDRSREDRGGGGGGGNGGVVGGSDRSYRDNRDDRYNRQRERGDRGDSPDRERDRERDRDRDRDRDRDRDRDRDRDRDRDRERDRDRSRRDRDRDRDRERERERERERERDRRGKRTDDRDRDDDHSRESSDIMMMISEHDHGRSYGSSSMEGVHYKSQTPNNTIMIRGLAQHITENDGILMLQDQYRALMQYSIPKDIHSDKAPSKNTQDWHCVKCGAHNFKRRETCFKCSASRAESEEGGEGSDEISSHPTNIVLLRGLDVLTTEDSVLQAMKNASAMPIRSIRIGRDSLTNTSRGVCYLEMGNVVDAMYLHTALTKQGLSVDERKVEVTYCKLNNQVNHSSIWKSMDNQQLQHQHHQQQQQQQQQQQPQRYTLEDVAQLAEYSANMYAKTPAQKAHYIQYYTQYYQNQISQGSLITLPSLNQTDRVNAAAAVAQSAIQQLQAARKLGDAEEMRGRPTPTAPTTTNLSTGRVPAHANDAIPDVSTYHYDELSGYYYDPSTGLYYDSNSQYYYNSHTQQFLYWDAESFSYQPAKTNVGGIISATGVTSAIGSIGDAPGNNPIITYSAQESLLKLDDDGKKKDVKQDKVKVAKKIAKDMERWAKTLNQKKENAKSNWTVDLGTSGLGVNSGSNDNNYSYQSNLSASGGGINCISGQEDRQHTDWIKIACLLCKRQFPSKDALLRHQQLSDLHKQNLENWYQVRGLDPNDPQQRNNKYRDRAKERRAKYGEPDPPQPNKLKEKYLKTRIEEAESSSLSSNYNQDSNKNNPNVIGSDNVGNKLLQKMGWSEGMGLGKTNQGRTSIIEAERRVSTAGLGAKTSTYSALPGDTYKDCVKKMMYARYQELSDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MPF3</accession>
    <name>A0A8J2MPF3_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Similar to DCTN2-p50: Dynactin subunit 2 (Aedes aegypti)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HICCMSTLAB_LOCUS4494</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the dynactin subunit 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5087362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MPF3"/>
    <dbReference type="OrthoDB" id="4977at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005869">
        <property type="term" value="C:dynactin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030286">
        <property type="term" value="C:dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028133">
        <property type="entry name" value="Dynamitin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15346">
        <property type="entry name" value="DYNACTIN SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04912">
        <property type="entry name" value="Dynamitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0243">Dynein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="102"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAG5087362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="412" mass="45997" checksum="8E3E552FAC1E854C" modified="2022-05-25" version="1">MADSKYADLPGIAYDQVDVYETTDLPESEQYSNDNEDETESIEKLHINASEAFNKFKGKSVATKGVDFSDKISGKPRTGYNAVYVDMLIIFGVWELPGEGEQETLIQKYQRLQCEIKELYDEVNALKENAKEEGEVKNAADILVQVEDIGKQLSILRIDECLGTDLVSTLTDPQGTRFKQLELQIEQFKNVGTVDKKPSDKGSGQTDKVPPSGTLKYEMIYLPERARMQETARIAQLEQRLARMEGVVGSGDDKLAKFTPNLKTQGVIEAIQQLAAKSALLDSTQVEVMEGRIATLCHRLDSVAQKKSALSADTERDQKIAEMYNIVQKTEPMAQVLPETIERMIALNAIHSRAAEFSKSLSQLEEVQSQITGSLESNKSVLKGIQESFASNLEAIRKNINHLEERLTKLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MPW6</accession>
    <name>A0A8J2MPW6_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Similar to REXO5: RNA exonuclease 5 (Bos taurus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HICCMSTLAB_LOCUS4870</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the REXO1/REXO3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5088491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MPW6"/>
    <dbReference type="OrthoDB" id="3996471at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06145">
        <property type="entry name" value="REX1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000019">
        <property type="entry name" value="RNA exonuclease NEF-sp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034922">
        <property type="entry name" value="REX1-like_exo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047021">
        <property type="entry name" value="REXO1/3/4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Ribonucl_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12801:SF82">
        <property type="entry name" value="RNA EXONUCLEASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12801">
        <property type="entry name" value="RNA EXONUCLEASE REXO1 / RECO3 FAMILY MEMBER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00929">
        <property type="entry name" value="RNase_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00479">
        <property type="entry name" value="EXOIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exonuclease" evidence="8">
        <location>
            <begin position="387"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="89"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="89"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="107"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="125"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAG5088491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="722" mass="82026" checksum="6913E0E2A0911F93" modified="2022-05-25" version="1">MYLIKEYLLKETQKCSESEFKRLSIVNVKWSLYLKIGELPIITMLTEKQRLRIEKKEKKIAAFLQIAKLNDEDKAKALKLKKSMESCSNNEAEVSAAQSPRRKRTCSESQNDEISTTSNETNPSENHETEQANKKPRLIGEEYQKLRQQLRERKKHLTSIPRFRIKGAGENASLTKNIDPRARVPIFLSDIQHLLMYSLVGNGAPYSPSRWCHLEKYNKVTHTVVFIVEGLSMYHFSSYESLFPNITDLLEHRLEVVTPATIGGSVIEQLAAVPLTTSERRKLIDKYGSLSVAEKKTGDIVKLLKYVFPMQSSVNIKSKNSLEKDKIQDNSIELPPGDKFPRTQLLLSLSQLIDENYPLRWPGALDSKYNNYINTKDVYLEATPKSPMFGLDCEMCTTTEGRELTRICIVDEQMNVVYETLVKPENKIVNYLTEYSGITEKLLENVTTNLSGVQEKIKELLPPDAILVGQSLCVDLDALKMMHPYIIDTSVIFNITGNRNHKSKLQVLAREFLNERIQEKKDGHCPTEDARAALKLAQLKLANSIDFGDAFVVGQQNLEEMLRKQKPDDNLVRDDDSYNFGVSIFKHVAKDKKTVSIVGTKEVLNDYSKYLITSSLSIMDDANFSKDDKVRLVTGNSNKHVVGRASEISMEHALTICHVKLTPEKVSEENLEKTCRNINKWVNKLWERMAVNGLACVIFSGHNNANGACFLNLKKEITPLQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MR54</accession>
    <name>A0A8J2MR54_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS8345</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5096708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MR54"/>
    <dbReference type="OrthoDB" id="7617398at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5096708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="166" mass="18769" checksum="F19B2880EB8443A6" modified="2022-05-25" version="1">MNEGVDWKSEVGKVWAKMEIGVGRKSMRKIGGLDENGKGLVLVEMDGFSKKKEVMLAKSKLKGEIVRIEDDLTFEERRVKNIIIEEAMKERALGKTVKVRYMKMWVNGVSDVCRPAISATSRGWQRNVTHIFLIIITEKYWCVLGSNPGTTLSESEHRADQAIANL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MRN3</accession>
    <name>A0A8J2MRN3_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS5778</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5090878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MRN3"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="90"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5090878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="121" mass="13344" checksum="9CBDA5C6F16302B0" modified="2022-05-25" version="1" fragment="single">IFEYYLKTERKMTGQALMDEVDLYEEYIRQKICDLLQAPRQPNKTKSEASQKNDTKDKNEVPAAASGDMNPELNITNPINNTHDDKSTSSEKSSVGDSSSSEGSSGPSDEESKSASDDSME</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MS00</accession>
    <name>A0A8J2MS00_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to pinta: Retinol-binding protein pinta (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS12176</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5106270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MS00"/>
    <dbReference type="OrthoDB" id="6682367at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902936">
        <property type="term" value="F:phosphatidylinositol bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10174">
        <property type="entry name" value="ALPHA-TOCOPHEROL TRANSFER PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10174:SF224">
        <property type="entry name" value="RETINOL-BINDING PROTEIN PINTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00650">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00516">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRAL-TRIO" evidence="2">
        <location>
            <begin position="36"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5106270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="201" mass="22595" checksum="4070E73D25531C49" modified="2022-05-25" version="1" fragment="single">MLSSSQSNVQSPQSEKSFASIDLSNEDDETVAKKIDEIRHVFIPLKQQNDGEKMIIIIRVSIHDPYKHKIANVIKTGKMILDVAIKDNMTVSTIGAIVIFDMSNVTLGHGLQMTPRVVQRLVHSWQGCYPVKINSLNFINAPIYVNGILNLFKSFMSHKMRTKVNVYSKTSEDLFSSIPKQQLPAEYGGFAGNLQSYISEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MTF9</accession>
    <name>A0A8J2MTF9_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">TPX2 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HICCMSTLAB_LOCUS7335</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TPX2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5094009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MTF9"/>
    <dbReference type="OrthoDB" id="7689066at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027329">
        <property type="entry name" value="TPX2_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06886">
        <property type="entry name" value="TPX2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TPX2 C-terminal" evidence="6">
        <location>
            <begin position="318"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="158"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="391"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="169"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF06886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAG5094009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="412" mass="47603" checksum="EC371C5C78C9170C" modified="2022-05-25" version="1">MDFRTSTPLVFPKEHSSRVHPNTEYQINTKRLFVITNDPNNNNNNNNNNNAGTNNNCNSGVFFNNYWEKINGPKFVDFANEIPEPRDSFFDGRQSICPTPVKEEEAMQIDNGIINTLENISLGSDIGEEDITLKADTTVFEQSIINCTTPNVDRRLSRLSTAPQPFSFETREKEKQERRQAKKQYQMSVSQQPPEFKARAAPKFKNVPKNPVKQIKKEEKRILQDFIPKKEVKVIHEIKPVCRGTIKEEAISPIQFYPVATADKSVTCNSDELNNYLASQAKNKNCAEAEKKKVEVWNQKPFQVNLPKRRILVPKSPKLRTAKRAEERKLYEEKLRLRELEFEDLRRTLSDSQKEKEKDEIARLRQMATFKARPMPKYPDVKVSVPFKRPLADPTVPLISKRPRLGTSKNSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MUA4</accession>
    <name>A0A8J2MUA4_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to ERC1: ELKS/Rab6-interacting/CAST family member 1 (Homo sapiens)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS8047</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5096113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MUA4"/>
    <dbReference type="OrthoDB" id="2019763at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019323">
        <property type="entry name" value="ELKS/CAST"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10174">
        <property type="entry name" value="Cast"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="27"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="87"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="331"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="400"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="632"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="37"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5096113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="699" mass="82289" checksum="2CB2A554E590680A" modified="2022-05-25" version="1">MVMNELNYLIIYYDYVDLHEANKKLQAGGAKPGADTSQERKQLEEHRRQLEEQRKQIEERARTSDGRMRAAEEKERALQTLDQDLKKRKAKMDQLEQQLQKSGGSPDKRLAEMQKALDTAEKELERAKEEAGRSSAETERLLQLMQMTQEEQNSKEKQIRELQDALKAAQAKLKQATTAQHQEKIKENYYNPDEINNGITNGDIEMWRGELKLKDRRIYELEMEIQSIEDFLNSHSETNGIVELQKIIKKKLSKIHKLETTVAEFEDFLKQNPDVKELHDLKCQVDLKERRIRDLESWIERNGDVGIEKTRIIELEQMVTHLEKYVKSHNVDALKQKLQDREERIEQLLKKIETLDKELMRREPIKNTNNLCDDELLNNFDDDEKMQIIKKVIYDKEVKMKEMEHAISEKDNSIQGYEQQVIELQDKIFKMVDEMKSMKIELSEYEAEDIGVLKEEIRVRDEKVQQLEEEIDSLERVFGDRMDLEEIEELLNVIKRKEEHQKQLELNLTKEKNENKELRAALRDSVAIANEAERKFKQTEKSKEDSIDRVKKLEQKGTTLQSTNALKCHSCRSLIKKFLKCEKNLKRLKDERRIQLKDLHHLRCESLKAALSEKDAHLALLELSAAKTVTQFDQMELLKADKARLLDELKKEDRKCIELSEEESSDSTTESTIVSKILEPTFVEDEDYLDNSQRAERRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MUQ8</accession>
    <name>A0A8J2MUQ8_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Similar to Slco1a5: Solute carrier organic anion transporter family member 1A5 (Rattus norvegicus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HICCMSTLAB_LOCUS13539</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the organo anion transporter (TC 2.A.60) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5108903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MUQ8"/>
    <dbReference type="OrthoDB" id="5062115at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016323">
        <property type="term" value="C:basolateral plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015347">
        <property type="term" value="F:sodium-independent organic anion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043252">
        <property type="term" value="P:sodium-independent organic anion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17336">
        <property type="entry name" value="MFS_SLCO_OATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002350">
        <property type="entry name" value="Kazal_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004156">
        <property type="entry name" value="OATP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11388">
        <property type="entry name" value="ORGANIC ANION TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11388:SF158">
        <property type="entry name" value="ORGANIC ANION TRANSPORTING POLYPEPTIDE 33EB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03137">
        <property type="entry name" value="OATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51465">
        <property type="entry name" value="KAZAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="50"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="89"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="116"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="183"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="220"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="264"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="343"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="393"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="425"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="541"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="578"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="627"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="domain" description="Kazal-like" evidence="10">
        <location>
            <begin position="461"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="666"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="736"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="880"/>
            <end position="960"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="687"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="757"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="774"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="883"/>
            <end position="892"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="893"/>
            <end position="907"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="909"/>
            <end position="923"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="925"/>
            <end position="936"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAG5108903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="960" mass="105677" checksum="BB848A1BC381FDEC" modified="2022-05-25" version="1">MVSGAREIMRFEEMEGELSGPAHPIPNESLDCGCAQLPCPKMAKYATRKLYVGIMCWIGVIQAAGQAYFSLTGSTVARRFNFPLNSIEWITLISDGIAPFLLALPIAYWGDRIHRAAWTGALVLIQSVGFFFIIIPHFSHLSPRVVEETTNITHLSLYSEDNPELCSASGLARVFVEEEGICYFTFTVVIIFQIVNCMGNIAYLALGISYLDDNTRKRHVAVPLGFLIAVKIVGTLLGYLVAWGCLRIDANDLSLGIESYREQFGAWWLGWPIFMILLAIPGVVLALLPRRLPSEVVEQAAASILDIAGRTSPLTESTVSGDTKKFGDTDFFSSLKRLFTNKIYLCNIFASVLIICAIVNFVHYEDLFLESRFWLPQPSGVLLGFRDPFTSRIVASILRPIVIGVVIICSGFIIAKVRPRAKWLVCYNITIVMIAAIIIFSLAFVDCKKPPISGSRSDGSISLLEYCNKNCRCSKDASFKPICDTRSKKIFYTSCHAGCTGVDTSSEVKKFTGCTCINSPLVPYNNSEVIDGLCDPSVCQIGWIVFEVSTILAYTLLSSGVISSILISLRSVFTQDKALAIGLWITLAAFITYIPGKMFYWQITDWTCIHRGDSQLCHLQSSNLGSYLSFATSFLLVLAVALDVLTYFFSFKLRIYREMELEPHDVAENSSQTQPIPLESLSKPDDSGSAAIGSGSGAATSSDGGAADAEPSIRATNHHNSSDIIEVTNSGLIHKANGPLKYGPVGPGDSDQYQDQNEDHDSDHEFRNKRAPISLTTNSYRRLGLNSDNDTSDSSRGSVKRFSVHQAAVETPLTKEDLKMQQNPVLAGFSRTDDIKFVKVEDHRKTGDFNEVGIPIVQYPLTSPNSRSIGSILISPEMTEHARRFRSKNNRPRFRDGETGRSGERNRPSSSHHTSSGFESSVSDRPNDSKAADVRRISKSTSNLGQPASKPKLYGYTTAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MV83</accession>
    <name>A0A8J2MV83_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similar to VPS50: Syndetin (Homo sapiens)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS13949</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5109313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MV83"/>
    <dbReference type="OrthoDB" id="10263345at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990745">
        <property type="term" value="C:EARP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032456">
        <property type="term" value="P:endocytic recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019514">
        <property type="entry name" value="Syndetin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040047">
        <property type="entry name" value="VPS50"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13258">
        <property type="entry name" value="SYNDETIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13258:SF0">
        <property type="entry name" value="SYNDETIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10474">
        <property type="entry name" value="Syndetin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Syndetin C-terminal" evidence="1">
        <location>
            <begin position="66"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5109313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="165" mass="19033" checksum="260C09520D54185F" modified="2022-05-25" version="1">MATPSTRKENCTKNYDGNIVIFSIEHGSAGPELKHYNLYVATSRQHHKNQHTESLVLDYDVTNTAASYSNARKCSNGGRGLMQLDYTQLKLKFESITGLRPMPYSEFVESYVKAYYIPENTLREWIKCHKEYSSKQLIGLVSCMYQNNKKSRQKFVTIIEDQSSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MX48</accession>
    <name>A0A8J2MX48_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">mitogen-activated protein kinase kinase</fullName>
            <ecNumber evidence="7">2.7.12.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HICCMSTLAB_LOCUS10257</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.12.2" evidence="7"/>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5101184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MX48"/>
    <dbReference type="OrthoDB" id="10252354at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008545">
        <property type="term" value="F:JUN kinase kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030707">
        <property type="term" value="P:follicle cell of egg chamber development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010508">
        <property type="term" value="P:positive regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043068">
        <property type="term" value="P:positive regulation of programmed cell death"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051239">
        <property type="term" value="P:regulation of multicellular organismal process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000040">
        <property type="entry name" value="Dual specificity mitogen-activated protein kinase kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48013:SF15">
        <property type="entry name" value="DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48013">
        <property type="entry name" value="DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="1"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="26"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="49"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="74"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAG5101184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="364" mass="41048" checksum="84FF4DBE7174A684" modified="2022-05-25" version="1">MAESQGNSSSNQLNQGSGRTFNFQRFDFRSNNDIQKESEKRRALKLSLPTQSSSLPANSSNSNSTSINPTGTSAGSPVPNSRPTLPLSMSKLPVKSRTPPQQGHFPDKARDKLRMCQSMQSTGKLQLSPDTVYDFTSEDLQDVGEIGRGGFGTRIRSTVDEREQNQLLMDLEVVMKSNECPYIVQFYGALFKEGDCWICMELMDTSLDKFYKFIYERLNKRIPECILGKITVATPERIDPQRARGYDVRSDVWSLGITLMEVATGYFPYPKWNSVFEQLYQVVQGDPPRLSPNGNGNHFTMEFVNFVNTCLIKEEHQRPKYNKLLDHAFIVRSEEATIDVAAYISSILDNMANNGVTPFTTDQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MXC7</accession>
    <name>A0A8J2MXC7_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Similar to SYMPK: Symplekin (Homo sapiens)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HICCMSTLAB_LOCUS10483</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5101581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MXC7"/>
    <dbReference type="OrthoDB" id="331600at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005847">
        <property type="term" value="C:mRNA cleavage and polyadenylation specificity factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021850">
        <property type="entry name" value="Symplekin/Pta1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032460">
        <property type="entry name" value="Symplekin/Pta1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022075">
        <property type="entry name" value="Symplekin_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15245:SF20">
        <property type="entry name" value="SYMPLEKIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15245">
        <property type="entry name" value="SYMPLEKIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11935">
        <property type="entry name" value="SYMPK_PTA1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12295">
        <property type="entry name" value="Symplekin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Symplekin/Pta1 N-terminal" evidence="4">
        <location>
            <begin position="98"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="domain" description="Symplekin C-terminal" evidence="5">
        <location>
            <begin position="748"/>
            <end position="923"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF11935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF12295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAG5101581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="962" mass="110613" checksum="6EEEB74863886B26" modified="2022-05-25" version="1">MSSLKNLIPTWFDEIATSGDDETKIENIAKIKQYFLDQKDPRLEIAYFQELLSYSSDINNDVRESIADFIEEAAGNKFQEKIPDLLPPLSRLVSDPVPKVSKRGIRASSWVLKAAYRWIVDASKVKITKEIQEVWNHLNFLKSQIINMVESENEGVRMQAIKFIENVVLFQTYLDPETPKSQSDFSLNDMLFTLEGTCCRNLEEEACRLVETMINYLQSSFITSIYLITSMGALGQIAKLRPKFTAQVIEAIIRLRKDLPPTLSASQIVGIKKESMRLIKILTSNVKIKQEPRDNCNSPVKRPLEQPKVDSRWKKLKLLQKDEISDDLIVKNLTVNTEMVIDAIARVPGNITPEEFEKKNSGFSVSADPEIKRRVIAKSLVMTQLKQSNELHNDKIDSEFIKLKSMKNIVSLSSADKQIMLVRSIDRIISYENSILTGQHVSNKIKILVRMATINVEIKKLLLIYISEDVKNRIDLALSMVYEEYALNHGFKRKIIIAKTTEGPFQLPYNYLLSAIIKIIESHPDRAVLLTRFYLAVPVISKEMIRSLTTKTPPETLTLLKELVFRRTTNKLEFLNILLGLTTHQDSSISDPAVDIILGLYNHGELRQSISEYLKANLNFLRLKNPPQVLLRKNVDRKMEHRWANSMVQSCLKLYQALLKEDKSLIYQLVKIYPLMTVDVKTSVKILMERSIRCFGANSPELLRIVETCPEGAESLVTRFVHTLTENRIPSSELVARMQKIYETRSLDIVFLIPVVRGLSREQVFSVLPKLITRNTLITKEVIKRLFFIREYTEFLITPVEFMITVHNFKKDVTDLKTIMICISMCLAEKKIFTQEVLQIVVSCLLDQTCLPITLMRTVMQILSLYPEMEKFVLSVLKKLILKKVWELPKLWQGFAKCCEMLKEKSFAVIHQLPQESIDNLFKIVPGLKNDYIDYLKPNSNFQRDNNNEIFSSKAVPFVSIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MY59</accession>
    <name>A0A8J2MY59_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS12490</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5106898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MY59"/>
    <dbReference type="OrthoDB" id="6704526at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035302987" evidence="1">
        <location>
            <begin position="23"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5106898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="69" mass="7909" checksum="8EDDFBCCDEF7F721" modified="2022-05-25" version="1" fragment="single">MSQFLLVKIFLTFSLIGVYVKADEGCREDCGENAFCNSCGNHCEQFCSDENQKPCTRVRLIIHENVYKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MZQ2</accession>
    <name>A0A8J2MZQ2_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to CAMK2B: Calcium/calmodulin-dependent protein kinase type II subunit beta (Bos taurus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS13009</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5107981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MZQ2"/>
    <dbReference type="OrthoDB" id="442176at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004683">
        <property type="term" value="F:calcium/calmodulin-dependent protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.450.50:FF:000009">
        <property type="entry name" value="Calcium/calmodulin-dependent protein kinase type II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013543">
        <property type="entry name" value="Ca/CaM-dep_prot_kinase-assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08332">
        <property type="entry name" value="CaMKII_AD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Calcium/calmodulin-dependent protein kinase II association-domain" evidence="2">
        <location>
            <begin position="220"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="169"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="171"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5107981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="359" mass="38875" checksum="B69833519189E679" modified="2022-05-25" version="1">MLTVNPSRRITASDALRHPWICQRERVASVVHRQETVDCLKKFNARRKLKGAILTTMIATRNFSSKYDAQARSIITKKGDGSQVKESTDSSTTIEDDDVKEDKKGGVDRSSTVIAKEPEGYASQGTPPNSPAAASIFSKVMGAAAASKQNQGCGNSLGIAAVLLHGAQADSGHGNSNSSSSGGSTSTSSQNSQTGILLSFPSVVSVNCPPRHRNSSAAARRQEIIKMTEQLIESINTGDFEGYTKICDPHLTAFEPEALGNLVEGMDFHKFYFDNVLGKNSSCKAVNTTILNPHVHLLGEDAACIAYVRLTQFVDKQGVAHTQQSEESRVWQKKDNKWQNVHFHRSAVTGPSPFSCNHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-10-16" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>S6CVX1</accession>
    <name>S6CVX1_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cc_single_21.2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">CcBV_21.2</name>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS941</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Philos. Trans. R. Soc. Lond., B, Biol. Sci." volume="368" first="20130047" last="20130047">
            <title>Functional endogenous viral elements in the genome of the parasitoid wasp Cotesia congregata: insights into the evolutionary dynamics of bracoviruses.</title>
            <authorList>
                <person name="Bezier A."/>
                <person name="Louis F."/>
                <person name="Jancek S."/>
                <person name="Periquet G."/>
                <person name="Theze J."/>
                <person name="Gyapay G."/>
                <person name="Musset K."/>
                <person name="Lesobre J."/>
                <person name="Lenoble P."/>
                <person name="Dupuy C."/>
                <person name="Gundersen-Rindal D."/>
                <person name="Herniou E.A.Drezen.J.M."/>
            </authorList>
            <dbReference type="PubMed" id="23938757"/>
            <dbReference type="DOI" id="10.1098/rstb.2013.0047"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CAJNRD030001114">
        <property type="protein sequence ID" value="CAG5074169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="HF586480">
        <property type="protein sequence ID" value="CCQ71391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S6CVX1"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036287020" evidence="2">
        <location>
            <begin position="18"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5074169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCQ71391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="66" mass="7483" checksum="55B443BE5FA35890" modified="2013-10-16" version="1">MFAKLLVFVLAMHMVMCTHMSITKHREPQMTQPTNASCMNQALSMPYLLMIEMGVLSAIILASRIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-10-16" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>S6CWI3</accession>
    <name>S6CWI3_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Cc_bv9.4_29.23</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">bv9-4</name>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS6140</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Philos. Trans. R. Soc. Lond., B, Biol. Sci." volume="368" first="20130047" last="20130047">
            <title>Functional endogenous viral elements in the genome of the parasitoid wasp Cotesia congregata: insights into the evolutionary dynamics of bracoviruses.</title>
            <authorList>
                <person name="Bezier A."/>
                <person name="Louis F."/>
                <person name="Jancek S."/>
                <person name="Periquet G."/>
                <person name="Theze J."/>
                <person name="Gyapay G."/>
                <person name="Musset K."/>
                <person name="Lesobre J."/>
                <person name="Lenoble P."/>
                <person name="Dupuy C."/>
                <person name="Gundersen-Rindal D."/>
                <person name="Herniou E.A.Drezen.J.M."/>
            </authorList>
            <dbReference type="PubMed" id="23938757"/>
            <dbReference type="DOI" id="10.1098/rstb.2013.0047"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5092440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="HF586473">
        <property type="protein sequence ID" value="CCQ71192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S6CWI3"/>
    <dbReference type="OrthoDB" id="7687020at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5092440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCQ71192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="128" mass="15169" checksum="FA1148CED3F4CA46" modified="2013-10-16" version="1">MTLPKKFAVVQFYEVSNLGQNPYKSVPKTWLEFGNSDDVFLRYPTAEELPFSIDRIINYAPPSLSWPRHAATFVCELDTYEECLFLMAHMDVNLPEEYAIMTWKKLSRELREIQTRQQSSSMFYQLWN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2E185</accession>
    <name>A0A8J2E185_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cytochrome b5 domain-containing protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HICCMSTLAB_LOCUS654</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Radial spoke stalk protein that binds heme under oxidizing conditions. Required for the coordinated beating of multiple cilia maybe by functioning in a redox signaling pathway.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Cilium axoneme</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the cytochrome b5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001114">
        <property type="protein sequence ID" value="CAG5073882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2E185"/>
    <dbReference type="OrthoDB" id="260091at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005930">
        <property type="term" value="C:axoneme"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052320">
        <property type="entry name" value="Cytochrome_b5_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21281">
        <property type="entry name" value="CYTOCHROME B5 DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21281:SF0">
        <property type="entry name" value="CYTOCHROME B5 DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0966">Cell projection</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3" id="KW-0349">Heme</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="11">
        <location>
            <begin position="15"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00040649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00046139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM01117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAG5073882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="222" mass="25872" checksum="81789BC2AF640884" modified="2022-05-25" version="1">MSQITFTKEKELPYFLPSEVVLHNSLSDCWVSYLGKVYDLTALCKSCEDRPEIKPILLFAGKDISHWFDRLTGDIQHHVDPRTGALVPYCPHGPIPDVGIPEPSSTWRPLEQVPWWRDTKYLLGNLTRNPRPCRVINTLIAKEALIWVCEEDTIKRIQERFKLFNSNSSDYLWKSEEKILDLNKTLTDNGIPDERERFLRCGLPDNFYVPSILCYYKDIVKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2E418</accession>
    <name>A0A8J2E418_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS2302</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001117">
        <property type="protein sequence ID" value="CAG5076859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2E418"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5076859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="93" mass="10319" checksum="5D8649D3CE2223A2" modified="2022-05-25" version="1">MTCGNSFKNPEEISPVLCMSSQKIISTRELEKISGKVCSTAETILHNCTSHLYPASDKIYTVTVVLYFCREVISAALKLGYFFYADADIVSLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2E4N3</accession>
    <name>A0A8J2E4N3_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS279</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001114">
        <property type="protein sequence ID" value="CAG5073320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2E4N3"/>
    <dbReference type="OrthoDB" id="7672739at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035320348" evidence="1">
        <location>
            <begin position="18"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5073320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="181" mass="20681" checksum="AB47213003D45888" modified="2022-05-25" version="1">MFQYFILIFNILGVILSEEDQVYKSHLKVSTRLDLSGSLKHLCAGDDQNDDDQVVSCACLSKLSVVSTVQVGKYQNVYHHNESNQNGVNAYASLYQTEENLKVLGFGRFNLHNVKCVENNEVKDVESRYTHWFHVYSTWSSLPPYNKFFDYEDYAADVLLPITIVDITLDNAPKFVSIVII</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2E5G8</accession>
    <name>A0A8J2E5G8_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Sulfhydryl oxidase</fullName>
            <ecNumber evidence="6">1.8.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HICCMSTLAB_LOCUS761</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10 6">
            <text>2 R'C(R)SH + O2 = R'C(R)S-S(R)CR' + H2O2</text>
            <dbReference type="Rhea" id="RHEA:17357"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:16520"/>
            <dbReference type="ChEBI" id="CHEBI:17412"/>
            <dbReference type="EC" id="1.8.3.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.8.3.2" evidence="6"/>
    <dbReference type="EMBL" id="CAJNRD030001114">
        <property type="protein sequence ID" value="CAG5073989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2E5G8"/>
    <dbReference type="OrthoDB" id="7645465at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016972">
        <property type="term" value="F:thiol oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.310">
        <property type="entry name" value="ERV/ALR sulfhydryl oxidase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036774">
        <property type="entry name" value="ERV/ALR_sulphydryl_oxid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017905">
        <property type="entry name" value="ERV/ALR_sulphydryl_oxidase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69000">
        <property type="entry name" value="FAD-dependent thiol oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51324">
        <property type="entry name" value="ERV_ALR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 6" id="KW-0274">FAD</keyword>
    <keyword evidence="2 6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ERV/ALR sulfhydryl oxidase" evidence="7">
        <location>
            <begin position="113"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU371123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG5073989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="240" mass="28669" checksum="3A2BC94E30B1EB9E" modified="2022-05-25" version="1">MLQFTRTFICHKYAFDENSINTLKENFNIYLNRFLAYIRTHKPVLNIKEEIHFAIFLKTLFKIVIIITRPNEPESICNEIDNMNSSYICYTMLYDECRKFFDLSEKINEVKLETADWTLDSWGKHYWNFLHALSILVQYCYQTKCDELLHNYVAALILNFDLILPCNTCRENYKLKKPLINLSLPIIYSKDVIFVLYNLHNNIRVTNGLEKFPFDQFLNSWNIKLLDAETKTVNARYLLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2E6K1</accession>
    <name>A0A8J2E6K1_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Gustatory receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HICCMSTLAB_LOCUS1394</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Cell membrane</location>
            <topology evidence="1 8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the insect chemoreceptor superfamily. Gustatory receptor (GR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001116">
        <property type="protein sequence ID" value="CAG5075240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2E6K1"/>
    <dbReference type="OrthoDB" id="6366728at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030425">
        <property type="term" value="C:dendrite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043025">
        <property type="term" value="C:neuronal cell body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007635">
        <property type="term" value="P:chemosensory behavior"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008049">
        <property type="term" value="P:male courtship behavior"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050909">
        <property type="term" value="P:sensory perception of taste"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013604">
        <property type="entry name" value="7TM_chemorcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21143:SF133">
        <property type="entry name" value="GUSTATORY AND PHEROMONE RECEPTOR 32A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21143">
        <property type="entry name" value="INVERTEBRATE GUSTATORY RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08395">
        <property type="entry name" value="7tm_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 8 9" id="KW-0675">Receptor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="57"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="95"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="145"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="173"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="248"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="284"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="363"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAG5075240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="388" mass="45560" checksum="A6C29342544342DB" modified="2022-05-25" version="1">MKHLKIVGYRYFQYFQYILFKISGLSPWKQEFSAFRKIATEDDSKNLAWNFSHAGSCYNILLFTVIIVMTLIEILKEELEVIETDTMFGAVSSKFMVISMLSASIIFIIYVVRQTILINVNNQFKVLDAELKNCADYRAEDDTNYSIFTLNFLMTIFTLAARGNVIQSVVRTLIWSTPFLISNWLIIQYTLLLFIIEKRFKRINRAVSKMGTVNSKISHSRESVLQDIGRIKLAYIILCDMCDQASNFYGFPTFISIFVLSIRSIFMLYYLILNLIRFEEMDTFIWLYASFLLRNVFLFTLLTTYVTKTIKENEKTIEVINELRDRYFMDEKIEQKLKKFSKNLLYMRVKFTVCDVLPLDRSLLAVISGTITTYLMIIIQFRLSSMSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2EB53</accession>
    <name>A0A8J2EB53_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS878</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001114">
        <property type="protein sequence ID" value="CAG5074106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2EB53"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5074106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="69" mass="7959" checksum="784EFC77D9B987B1" modified="2022-05-25" version="1">MVAQILFKISSCWNAYKNFNILLIGHFSESLIRNELTYSTPKLFVLLHDRLLYNIPSIANCNSLNLSLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2EBT0</accession>
    <name>A0A8J2EBT0_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">serine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Seryl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HICCMSTLAB_LOCUS1226</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.11" evidence="2"/>
    <dbReference type="EMBL" id="CAJNRD030001116">
        <property type="protein sequence ID" value="CAG5075040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2EBT0"/>
    <dbReference type="OrthoDB" id="10264585at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004828">
        <property type="term" value="F:serine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006434">
        <property type="term" value="P:seryl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000078">
        <property type="entry name" value="Seryl-tRNA synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002317">
        <property type="entry name" value="Ser-tRNA-ligase_type_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11778">
        <property type="entry name" value="SERYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00981">
        <property type="entry name" value="TRNASYNTHSER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="8">
        <location>
            <begin position="33"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00031113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAG5075040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="300" mass="33633" checksum="6AE77EC64CD05FCA" modified="2022-05-25" version="1">MDLVKNLKLIRIENLGPVSGPKSYILLGDLAEMEEALVQYSVRKLLKQGFRLVSVPDILPTTVIERCGMVMDGEHHLIYTLDKAYGDVCLSGTAEMALAMKMMNKVIDGDSLPVKLAAVSRCFRAEASNNVEEAGIYRVHQFTKVEMFACTSEDKSSQFLEELLEIQENIFQDLGLGFKTIDMPSHELGAPAYRKIDIEGWLPGKNVYGELSSCSNCTDFQSRRLNIKYKANNNNEAKYVHTLNGTACAVPRTLIAICETHQLKNGNIEVPEVLVPFMNGKKIIETQNVGEMRTYKFKNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2EC11</accession>
    <name>A0A8J2EC11_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Similar to Ankrd28: Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A (Mus musculus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HICCMSTLAB_LOCUS1343</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001116">
        <property type="protein sequence ID" value="CAG5075189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2EC11"/>
    <dbReference type="OrthoDB" id="7696926at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24188">
        <property type="entry name" value="ANKYRIN REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24188:SF29">
        <property type="entry name" value="GH09064P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13857">
        <property type="entry name" value="Ank_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="29"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="22"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="24"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="109"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="143"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="179"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="213"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="249"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="349"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="382"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="417"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="451"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="486"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="520"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="554"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="589"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="656"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="690"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="724"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="758"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="792"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="826"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="861"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="895"/>
            <end position="929"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="930"/>
            <end position="963"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="964"/>
            <end position="998"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="999"/>
            <end position="1032"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG5075189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="1042" mass="116339" checksum="384285A48CB3B579" modified="2022-05-25" version="1">MRKLKSSFGKLLQMQRLARKSNTNEKTEQELSGIVKKIQSKMGDLGLFEAIKRMDLKAVEWFINNGANVNSNRTNVTSLFFALEESGDSRIVKCLINHGANVNKVAGYSKTTPLHLAVEKWTDISIIECLVNHGANVNAVDYNKETPLHYAINNKKSKEIIEYLVNHGANVNEVAGCYSETTPLHLAVEKWTDISIIECLVNHGANVNAVDYNKETPLHYAINNKKSKEIIEYLVNHGANVNEVAGCYSETTPLHLAVEKWTDISIIECLVNHGANVNAADKSKQTVLHYAAERNLSVIEFLISHRSNVNAIDSCKRAPLHSVLSNHLNCCEAVKHLIDNGADVNEVDSEGTVLHYALKRRNLSAVKLLINHKVNVDVVNSVGQTLLHLAAIWNSKDEKIYEHLVEHGANVNAVDKLKKTPLHYATKHWNNPEIVKYLIEHGANVNVVDNIGFTPLWQAVYSGRRFFKPVKYLVEGGSDINYKNEGGQTPLHLVASGKGWFEMMRFLVPRGADVHAVDNNDWTPLHRAAHDSKDVRIIEYLINRGANVNAVNKDNNTPLHLAVEKCPVLHDVVNYLIDRGADLNAINNEKETPLHVAAHRSGKEAIELLVNRGANINARNGICKPLLISLIEKCKNFKEIDCLIQLGANVNAVDHQNKTPLHYASAKSYKTELMKKLIQRGANVNLTDNDKKTPLHNAIEKASGNDNAIYLIEHGADIHAVDHQSRTPLHYACAKSYNTELMKKLIQRGANVNLTDNDKKTPLHNAIEKASCNDNAIYLIEHGADIHAVDHQSRTPLHYACAKSDCTYLIEKLIKRRANVDSTDSDKKTPLHIAIENGSRGYDHANYLIEHGADIHAVDHQNKTPLHYACAKSDCTYLIEKLIKRRANVDSTDSDKKTPLHIAIENGSCGYDYANYLIEHGANIHAVDHRNQTPLHYASAKSNSVILIKKLIEYRADINSPDSDKKTPLHIAIENASEDYNNAEYLIEHGANIHAVDHRNQTPLHYASANSNSTELIKKLIEREANVNSRGNDKKNIFTQSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2ECM8</accession>
    <name>A0A8J2ECM8_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 13">Small nuclear ribonucleoprotein Sm D3</fullName>
            <shortName evidence="13">Sm-D3</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11 13">snRNP core protein D3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">HICCMSTLAB_LOCUS1664</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 13">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the snRNP core protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001116">
        <property type="protein sequence ID" value="CAG5075510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2ECM8"/>
    <dbReference type="OrthoDB" id="6425924at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000387">
        <property type="term" value="P:spliceosomal snRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01721">
        <property type="entry name" value="Sm_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000002">
        <property type="entry name" value="Small nuclear ribonucleoprotein Sm D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027141">
        <property type="entry name" value="LSm4/Sm_D1/D3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034099">
        <property type="entry name" value="SmD3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23338">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 13" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8 13" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="9 13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 13 16" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="7" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Sm" evidence="15">
        <location>
            <begin position="5"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="81"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="96"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="125"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00033126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00058057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU365050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CAG5075510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="142" mass="15392" checksum="DBC06B48193F41DC" modified="2022-05-25" version="1">MSIGVPIKVLHEAEGHIITCETNTGEVYRGILIEAEDNMNCQMQNITVTYRDGRVAQLENVYIRGSKIRFLILPDMLKNAPMFKRPGGKGSGTAGRGKSAILRAQARGRGRGQNQRGRGTGSAPWLNQQTQPSGSQAGRGRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2EFR6</accession>
    <name>A0A8J2EFR6_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Sugar transporter SWEET1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">HICCMSTLAB_LOCUS675</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SWEET sugar transporter family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001114">
        <property type="protein sequence ID" value="CAG5073903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2EFR6"/>
    <dbReference type="OrthoDB" id="409725at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051119">
        <property type="term" value="F:sugar transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1280.290:FF:000004">
        <property type="entry name" value="Sugar transporter SWEET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047664">
        <property type="entry name" value="SWEET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004316">
        <property type="entry name" value="SWEET_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10791">
        <property type="entry name" value="RAG1-ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10791:SF112">
        <property type="entry name" value="SUGAR TRANSPORTER SWEET1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03083">
        <property type="entry name" value="MtN3_slv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="12 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <keyword evidence="7 14" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="8 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="36"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="68"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="99"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="128"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="14">
        <location>
            <position position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CAG5073903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="158" mass="17485" checksum="1D7F60ED55938E89" modified="2022-05-25" version="1" fragment="single">LVCRKYIINGTTGDTSGFAFLGYIAIYTLCCIKKTIILRQFLSAVLFIAIVYSWSIAEEDKSLATEHVGILSCGFTILFFASPLTMLAHVIKHKSADSLPFPVIISSLVVSCQWFAYGTLIDDLYIQLPNFLGCVLSAFQLSLFVIFPSKKNGEVRLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2EJ13</accession>
    <name>A0A8J2EJ13_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Similar to SOAT1: Sterol O-acyltransferase 1 (Macaca fascicularis)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HICCMSTLAB_LOCUS869</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the membrane-bound acyltransferase family. Sterol o-acyltransferase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001114">
        <property type="protein sequence ID" value="CAG5074097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2EJ13"/>
    <dbReference type="OrthoDB" id="10039049at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008374">
        <property type="term" value="F:O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008203">
        <property type="term" value="P:cholesterol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004299">
        <property type="entry name" value="MBOAT_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014371">
        <property type="entry name" value="Oat_ACAT_DAG_ARE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10408:SF8">
        <property type="entry name" value="O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10408">
        <property type="entry name" value="STEROL O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03062">
        <property type="entry name" value="MBOAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="43"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="67"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="98"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="154"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAG5074097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="175" mass="20873" checksum="04709FDF9E234897" modified="2022-05-25" version="1">MWDWWTSVSYGKYYRTWNIVVYDWLYTYIYRDLYEKLFPGNKLIATFSVFFTSAVIHEYILACVFRFFYPVMFVFFGGFGFVLVLITKKESSEIGNIFLWFSLITGSGMMVSFYTMEYFARLNCPGLKDELLDFFVPRSWLCYDQFSGDGENHLVLYISSLSFLTVFTLLYKKFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2EJG0</accession>
    <name>A0A8J2EJG0_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Similar to wfs1: Wolframin (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HICCMSTLAB_LOCUS1142</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001116">
        <property type="protein sequence ID" value="CAG5074931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2EJG0"/>
    <dbReference type="OrthoDB" id="5865303at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055074">
        <property type="term" value="P:calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030968">
        <property type="term" value="P:endoplasmic reticulum unfolded protein response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045400">
        <property type="entry name" value="Wolframin_Cys-rich"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045460">
        <property type="entry name" value="Wolframin_EF-hand"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026209">
        <property type="entry name" value="Wolframin_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045461">
        <property type="entry name" value="Wolframin_OB_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045458">
        <property type="entry name" value="Wolframin_Sel1-like_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13098">
        <property type="entry name" value="WOLFRAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13098:SF3">
        <property type="entry name" value="WOLFRAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20053">
        <property type="entry name" value="WC-rich"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19913">
        <property type="entry name" value="WCOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19914">
        <property type="entry name" value="WEF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20023">
        <property type="entry name" value="WSLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02060">
        <property type="entry name" value="WOLFFAMILY"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="294"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="323"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="415"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="448"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="485"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="508"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="domain" description="Wolframin EF-hand" evidence="3">
        <location>
            <begin position="101"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="Wolframin cysteine-rich" evidence="4">
        <location>
            <begin position="537"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="domain" description="Wolframin OB-fold" evidence="2">
        <location>
            <begin position="633"/>
            <end position="747"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF19914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF20053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAG5074931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="747" mass="84070" checksum="CFCF75C537D357BB" modified="2022-05-25" version="1">MAGVVPISGKPFRKQWFLQDGCADSQVVLAKKLLEERCDLDVDTEENAKLAVYWLTKASEQGNLEATKILQHCFTTGHGITEHNYQDAKSCLEMSQQEKLARNAARLLFTALSNGEDFITSEQLRRHLSPASSSRNSPPPLEYLSDPERISESQLVSAAASYSRGLLPSLSPPLPLPLTPFYPPWREPLSFCRRLYHKLLLFSQNSALFTSRFFTLLLILTYCLLGTESLLLFLPLLFYYLSFVLMTFATLQMLHSGTQLSTFRSWSRLFISYSSSLDPQEAEFQFCRNNLKPYGHFFLSLLLNLMIYPLIAHQWTPQSEFTLIAFTLTLLTLLNFSSPDPLVLFSFAIHVLAKYPYELDIVVAQTWRFLDIRVPTFASYVIGNSIEFCLNFRAVFYLLIPAIFLKLAARNSWKGTYQLLIPHCVTLSWWQIAILSSQGATMYGLIRAALALVGVVMFLPIVGVASIILPILALTKYLLADWRNNLATAFLAAAPFGTFWYRRRWFSSAQIILGLTAGAFLIWPTNLDPAPSESLSWEAYQNFCHQPAWEEAPKAQVQVACDALTDLPVTWEGYVTDVKLRRVRNPLRDFFGGAWVPEGVAKKLSCLLGEKADCKEGNCGVLMKLRPCNVDGWNKFEFEVFVKMKSSLWGSHSEIVLNAGHEFKNFSLNIYPGDKIWFKGRLSNGGERENLLGGVRPHVNIVEAQCLLCHVGELRAGQGGVKDLVGVIVSGGKSVLNFVLNPLVIFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2EJG8</accession>
    <name>A0A8J2EJG8_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Poly [ADP-ribose] polymerase</fullName>
            <shortName evidence="1">PARP</shortName>
            <ecNumber evidence="1">2.4.2.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS1157</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.-" evidence="1"/>
    <dbReference type="EMBL" id="CAJNRD030001116">
        <property type="protein sequence ID" value="CAG5074946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2EJG8"/>
    <dbReference type="OrthoDB" id="4772757at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003950">
        <property type="term" value="F:NAD+ poly-ADP-ribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990404">
        <property type="term" value="F:NAD+-protein mono-ADP-ribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.228.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051712">
        <property type="entry name" value="ARTD-AVP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012317">
        <property type="entry name" value="Poly(ADP-ribose)pol_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45740">
        <property type="entry name" value="POLY [ADP-RIBOSE] POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45740:SF17">
        <property type="entry name" value="POLY [ADP-RIBOSE] POLYMERASE TANKYRASE-2-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00644">
        <property type="entry name" value="PARP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56399">
        <property type="entry name" value="ADP-ribosylation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51059">
        <property type="entry name" value="PARP_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="1" id="KW-0520">NAD</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PARP catalytic" evidence="2">
        <location>
            <begin position="8"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU362114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5074946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="248" mass="27117" checksum="9B8CA887DB95EAA6" modified="2022-05-25" version="1">MDKLLNSATTLWQPSLSSTPGTLLVDLLVDDKEFLAVVEEMQSGIREHRDNGHSGGIFSRYNIVRIQKVQNRKLWERYAHRRQEVAEEVIAAGPCGSPPSGSGASRATPTPATTIPQANERMLFHGSSFINAIVQKGFDERHAYIGGMFGAGIYFAEHSSKSNQHLLLCRVTLGKSFLQFSAMKMAHAPPGHHSVMGKPSQGGLAFPEYVVYRGEQAYPEYLITYQIVGPQASSSRAGAPDSEPDASR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2EJX2</accession>
    <name>A0A8J2EJX2_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS1541</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001116">
        <property type="protein sequence ID" value="CAG5075387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2EJX2"/>
    <dbReference type="OrthoDB" id="7699940at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5075387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="217" mass="24408" checksum="16E893283595FC75" modified="2022-05-25" version="1">MTIEQTLNRFFGTDLKHGRGVTPSVVARYLTCMPVSFAVMDGLESYCDLSFSTSEQHIDLTNSRLKKDNNDLMLMYNWILAHKPFEHRESLTSLSTGIVGGENINCHEALKLGTLSMGAMIGKNAQNVSMCFKYEVKPLSTAKAGIHADVKYANLNPMMLFQRICVLTKDDEDLTKKAFSHELSPFPLSLFDQEGFMRKNKKSELFSVFKTSLQSDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2EKT5</accession>
    <name>A0A8J2EKT5_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">arginine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HICCMSTLAB_LOCUS2181</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>tRNA(Arg) + L-arginine + ATP = L-arginyl-tRNA(Arg) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:20301"/>
            <dbReference type="Rhea" id="RHEA-COMP:9658"/>
            <dbReference type="Rhea" id="RHEA-COMP:9673"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78513"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.19"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.19" evidence="2"/>
    <dbReference type="EMBL" id="CAJNRD030001117">
        <property type="protein sequence ID" value="CAG5076414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2EKT5"/>
    <dbReference type="OrthoDB" id="68056at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004814">
        <property type="term" value="F:arginine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006420">
        <property type="term" value="P:arginyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00671">
        <property type="entry name" value="ArgRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000084">
        <property type="entry name" value="arginine--tRNA ligase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.730.10:FF:000064">
        <property type="entry name" value="Probable arginine--tRNA ligase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.730.10">
        <property type="entry name" value="Isoleucyl-tRNA Synthetase, Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001278">
        <property type="entry name" value="Arg-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035684">
        <property type="entry name" value="ArgRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008909">
        <property type="entry name" value="DALR_anticod-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00456">
        <property type="entry name" value="argS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11956:SF5">
        <property type="entry name" value="ARGININE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11956">
        <property type="entry name" value="ARGINYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05746">
        <property type="entry name" value="DALR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00750">
        <property type="entry name" value="tRNA-synt_1d"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01038">
        <property type="entry name" value="TRNASYNTHARG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00836">
        <property type="entry name" value="DALR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DALR anticodon binding" evidence="10">
        <location>
            <begin position="329"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAG5076414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="452" mass="51808" checksum="C180E535EBAD0D9F" modified="2022-05-25" version="1">MHVGHLRSTIIGESLSRLLEYLGHDVLRLNHVGDWGTQFGMLIAHLQDKFPDYATVSPPISDLQGFYKESKKRFDEDEEFKKRAYACVVKLQAGDPEITKGWQLICDVSRKEFDNLYRRLDIKLIERGESFYNKMMIEVVKELEDKGLLEEDEGRKIMWGEKPNSGIPLTIVKSDGGFTYDTSDMACIKHRIHVEKGDWLIYVTDAGQAGHFQLIESCGKRAGYVKPETRVSHVGFGVVLGEDKKKFKTRSGDTVKLLDLLDEGLKRALDKLIEKGRDKELNEEELRAAQEAVAYGCIKYADLSHNRNHEYIFSFDKMLEDRGNTAVYLLYQLTRIRSIARNAKVSEEQIKSAVDLTMISLEHEKEWKLAKVLIKFPDVLLKVTKDLVLHPLCEFCYELSCAFSEFYDKCYCVENVNGEMKVNMGRILLCEATALVLEQCFYLLGLKPVAKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2ENZ1</accession>
    <name>A0A8J2ENZ1_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Similar to foxo: Forkhead box protein O (Drosophila virilis)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">HICCMSTLAB_LOCUS2072</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subunit">
        <text evidence="12">Interacts with melt.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 13">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001116">
        <property type="protein sequence ID" value="CAG5076091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2ENZ1"/>
    <dbReference type="OrthoDB" id="5954824at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001766">
        <property type="entry name" value="Fork_head_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032067">
        <property type="entry name" value="FOXO-TAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45767">
        <property type="entry name" value="FORKHEAD BOX PROTEIN O"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45767:SF2">
        <property type="entry name" value="FORKHEAD BOX PROTEIN O"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00250">
        <property type="entry name" value="Forkhead"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16676">
        <property type="entry name" value="FOXO-TAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00339">
        <property type="entry name" value="FH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50039">
        <property type="entry name" value="FORK_HEAD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0010">Activator</keyword>
    <keyword evidence="11" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="5" id="KW-0221">Differentiation</keyword>
    <keyword evidence="7 13" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10 13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Fork-head" evidence="15">
        <location>
            <begin position="91"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Fork-head" evidence="13">
        <location>
            <begin position="91"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="40"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="147"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="281"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="361"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="538"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="288"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="315"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="361"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="381"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="392"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="538"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="551"/>
            <end position="566"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00038846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CAG5076091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="566" mass="62234" checksum="B216C0F24F0E119A" modified="2022-05-25" version="1">MDTEIMDSSLSAPSPARQTATQGLSFELESGFEPQIRARSNTWPLPRPEGYVDASDSNGKDDPNANALLQQVALGNALIPLKKNSSRRNAWGNLSYADLITQAITSATEKRLTLSQIYEWMNSIRHNLSLHNRFMRVQNEGTGKSSWWMINPDAKPGKSARRRATSMETSKFEKRRGRVKKKVEALRNGLQTDAATSSPSSSVSEGLDLFPESPLHTSSFQLSPDFRPRASSNASSVGRLSPIPAVLGEPDWTPSYVSSYSPEQLAGNLAEAMKLESYQMYQPSPGSQQQQQQQQQQQQQQQQQQQQQPPPSYFEAQQYSRSNSMRTAASPYSLPAQPNNHHQRCSIHRLQTCSCQMNTSPVSGMSPTYHQNDSRPSLCAQQSPTQPQQQLKEPKQDRKEQPQSFPYLMQCQQRLQNQNQQTVSVNSSPSAAVNFLDGSSDLSCCNNLDLNAASTMMGELMGALNNSALLDDLNINIEGLHGGFDCNVDEVIKHELSMDGTLDFNFQNGVIDPALDSVTDDDIIQGNVMGANNTVNSPAPVTSASGTSYVTTNNPTAATATPSWVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2GZN6</accession>
    <name>A0A8J2GZN6_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS857</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001114">
        <property type="protein sequence ID" value="CAG5074085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2GZN6"/>
    <dbReference type="OrthoDB" id="307899at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006120">
        <property type="term" value="P:mitochondrial electron transport, NADH to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13156:SF0">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] IRON-SULFUR PROTEIN 6, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13156">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE 13 KD-A SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5074085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="85" mass="9792" checksum="3F55D8B480EC4539" modified="2022-05-25" version="1">MAGKQVCCFLSNSNKFLKTKLPISCVITRSNASWEPKDAVTHTGQKFDPEDRRLVRFVDRPKEDKPGNHACGYCGLRFYKEDHHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2GZV9</accession>
    <name>A0A8J2GZV9_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS1175</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001116">
        <property type="protein sequence ID" value="CAG5074964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2GZV9"/>
    <dbReference type="OrthoDB" id="6415662at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5074964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="172" mass="19388" checksum="F8B43E0B767F5531" modified="2022-05-25" version="1">MPPRRANPQPCCSITTAFACTGSVLSFGVAVRVTIPRNFKSGTHNLNKLGRLKVDCSTTGQSGIISEINKQVTYFCKLLSIGEPSFLRELFIEDEFRRSERLAIKNNNVNNLILKFATSYLEHSFVISAIRLWQKLPVEVLDASSLEVMLPSFVYYIVTQHFYCTFAANLLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H0M9</accession>
    <name>A0A8J2H0M9_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Similar to PIK3C2B: Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta (Homo sapiens)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">HICCMSTLAB_LOCUS2354</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4-bisphosphate) + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18373"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57658"/>
            <dbReference type="ChEBI" id="CHEBI:58178"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.154"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:18374"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12709"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57880"/>
            <dbReference type="ChEBI" id="CHEBI:58088"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.137"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:12710"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the PI3/PI4-kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001117">
        <property type="protein sequence ID" value="CAG5077039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="67688at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005942">
        <property type="term" value="C:phosphatidylinositol 3-kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016303">
        <property type="term" value="F:1-phosphatidylinositol-3-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035005">
        <property type="term" value="F:1-phosphatidylinositol-4-phosphate 3-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043491">
        <property type="term" value="P:phosphatidylinositol 3-kinase/protein kinase B signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048015">
        <property type="term" value="P:phosphatidylinositol-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04012">
        <property type="entry name" value="C2A_PI3K_class_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05166">
        <property type="entry name" value="PI3Kc_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06884">
        <property type="entry name" value="PX_PI3K_C2_68D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1520.10:FF:000006">
        <property type="entry name" value="Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1070.11:FF:000003">
        <property type="entry name" value="Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1010.10:FF:000001">
        <property type="entry name" value="Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.70:FF:000014">
        <property type="entry name" value="Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000205">
        <property type="entry name" value="Uncharacterized protein, isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1070.11">
        <property type="entry name" value="Phosphatidylinositol 3-/4-kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1010.10">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.70">
        <property type="entry name" value="Phosphatidylinositol 3-kinase, accessory domain (PIK)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015433">
        <property type="entry name" value="PI3/4_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000403">
        <property type="entry name" value="PI3/4_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036940">
        <property type="entry name" value="PI3/4_kinase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018936">
        <property type="entry name" value="PI3/4_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002420">
        <property type="entry name" value="PI3K-type_C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001263">
        <property type="entry name" value="PI3K_accessory_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042236">
        <property type="entry name" value="PI3K_accessory_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000341">
        <property type="entry name" value="PI3K_Ras-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10048:SF14">
        <property type="entry name" value="LD28067P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10048">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00454">
        <property type="entry name" value="PI3_PI4_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00792">
        <property type="entry name" value="PI3K_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00794">
        <property type="entry name" value="PI3K_rbd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00613">
        <property type="entry name" value="PI3Ka"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00142">
        <property type="entry name" value="PI3K_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00144">
        <property type="entry name" value="PI3K_rbd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00145">
        <property type="entry name" value="PI3Ka"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00146">
        <property type="entry name" value="PI3Kc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51547">
        <property type="entry name" value="C2_PI3K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00916">
        <property type="entry name" value="PI3_4_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50290">
        <property type="entry name" value="PI3_4_KINASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51546">
        <property type="entry name" value="PI3K_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51545">
        <property type="entry name" value="PIK_HELICAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PI3K-RBD" evidence="14">
        <location>
            <begin position="447"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="domain" description="C2 PI3K-type" evidence="15">
        <location>
            <begin position="734"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="domain" description="PIK helical" evidence="13">
        <location>
            <begin position="913"/>
            <end position="1097"/>
        </location>
    </feature>
    <feature type="domain" description="PI3K/PI4K catalytic" evidence="12">
        <location>
            <begin position="1177"/>
            <end position="1452"/>
        </location>
    </feature>
    <feature type="domain" description="PX" evidence="11">
        <location>
            <begin position="1490"/>
            <end position="1606"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="10">
        <location>
            <begin position="1632"/>
            <end position="1751"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="61"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="171"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="61"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="107"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="174"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CAG5077039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="1757" mass="198381" checksum="9E94C8B98404EA32" modified="2022-05-25" version="1">MSNHAKNESIQRGAVMDYDKQFQEDLERAQALSLESLALEKFKLQKQLECSNNFFTAQQCSQSNSSNVSEVDSSTSMDKLQLRSRPRPGGTQSKNSPIIAPPPIPSRRNSTTTVGPASSNTTDLINFTSPVKSESSLDDYCSSTIASAVPTISQPSIEPKWDTHPSLLKRTTRVSRSNSSAAAYQTHDFRYHSPSPGPRASTAPCTPGTPGISPVITQAESVGDGIPQIPPLPMNYRPPLTGPPATKPIFPIEDNQLQVLKVIEKKPNNNLIDLSAFENPEDKTNVRVSVLEAFDPLLIKTEALKEPTPSKNEPSQTDGSVYDPFDPFDYMYSTNESISSDPVYAAVEKTPTSPAVSPAAPPLPPRNSSAWNTIEKRRTSLDRRRKRQTRLYENITVVKARASLQDCDLKAFHLMIKSIRSEFPFNDPNTNIGHVISPMMENLYPDGTSIKLVVHPQLVGGSDNSDNPVAPSINFTCNVSCSVEHVILNVACSLEDNIVNADKYCLRVWGLAEYLAPNTTLAQYEYIHQCIKLEKDIELAIITRAQIKRSIARSLQDDNRDQDLKLEDILPNEPLEPISYDTLIILLETVEKEMERVETAAIQLAAPNHSSSLLPQLQPRGVVQSVKAVCALMGNIETYEITEAVDNFVNACCQFLPQMHTTNIECKKPEILHEDGDYSVVTLRTKFPELLGSHCHKIRDAIQDLVETYCNAFRVDFHKLRGEYLANSLVSSEVLDTVLVRVGALHRIPNSWKHDDYIVAAQIFHGTRPVGNPVLSEPMTLNVNFYSRILFNTWLEFRGLSVCQVPREARLVLVIYGRTLQPTEHDNNSGEGSMQKEELGWGAIQFFDYDGVMSQGNFFLSLWPAAADKRLGPAPAPGIHPYGETNPIIGLELPDYGGRVLFPTELRDHDVESLDINLLDQNTKELLIDICQQDTFSRPPIDEREILWEKRHYLHEIPEALPKVLLAAHSWDWACLPDLHASLRVWSPLPPVQALQLLLPCFPDIKVREMAVGWIRELSNDELVDYLPQLLQALKHETYEASPLARFLLERALLSPRVAHHIYWLLTQSLPGQSPQNSGESSQEDDRSISFTRYQRRLQLMLRALLAVIGEALRNSFLTQQLLVKNLNEIAENIKTTKESLRMESLKLGLQNIHGQLAEDEGTCLPLSPSRQVFGINIQTCSYFPSFTLPLKISFISCDNVISPAIFKVGDDLQQDMLTIQMVRIMDKLWLKEGLDLKMVTFACVPTGNKRGMIEMVTNAETLRKIQVEFGLTGSFKDRPIAEWLAKHNPSELEYERAVENFTRSCAGYSVATYILGICDRHNDNIMLKTSGHLFHIDFGKFLGDAQMFGNFKRDRTPFVLTSDMAYVINGGDKPSAKFHNFVDLCCQAFNIVRKHGNLILHLFGLMTSSGIPGVTMDAVSYVQKALLPGQTNPEAAATFARMIESSLKNWFTQFNFFLHNLAQLRFTGDHNDGELLSFIPRTYTMQQEGQLTSVQVHGYQKRYDPEKYYMYILRIQRKGQPDPTYLFRSYKEFCEFYQKLCIHFPLAKVASLPNGMSVGRSNIKQVADKRRADIEKFLLSLFKMAPEISQSDLVYTFFHPLLRDQQNADIHLRKVKVGNWWAEKRVRDNIQCGQIKLSLHYSRGTLSVMIHHARGLPKVANAQEPNTYVKVYLKPDPTKATKRKTKVVKKNCHPSFMEMLEYRMPLDVVKERTLEATIWNHDTLQENEFLGGIRLPLGHFELTNETIEWFPLGSIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H669</accession>
    <name>A0A8J2H669_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HICCMSTLAB_LOCUS2656</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001117">
        <property type="protein sequence ID" value="CAG5078140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H669"/>
    <dbReference type="OrthoDB" id="6631139at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012464">
        <property type="entry name" value="DUF1676"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21879">
        <property type="entry name" value="FI03362P-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21879:SF2">
        <property type="entry name" value="OSIRIS 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07898">
        <property type="entry name" value="DUF1676"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035228670" evidence="3">
        <location>
            <begin position="23"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="130"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="160"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="249"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG5078140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="278" mass="29812" checksum="C1CE16E591EE1C4F" modified="2022-05-25" version="1">MRFVSVISISVFLLSICGLSSASRPDFITKSVNQCIGAESWTGCLKQEVLEYLDDKLGTTTEARSLESVDEALIVRTAKYLKSFEYGVNLPFVDAKLKYRPGRSLADLDIEFQDNEVATSQARGLLKKKLLLPILLLLKLKLKALMPIFVALIGLKAMKALILSKLAILLVVGFIAVQFFKKGGMTPPMGMTMEPAPAGSYGAPPAPSTTSGYEPVNTWDGNGPYSRVWTPSNGETAQNLAYNYYAPSSNSGSSNSYGAPLSSSSSASASSSSSSTNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H6C7</accession>
    <name>A0A8J2H6C7_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Endonuclease/exonuclease/phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS2767</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001117">
        <property type="protein sequence ID" value="CAG5078519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H6C7"/>
    <dbReference type="OrthoDB" id="7699669at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061343">
        <property type="term" value="P:cell adhesion involved in heart morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007508">
        <property type="term" value="P:larval heart development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33395:SF21">
        <property type="entry name" value="PERICARDIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33395">
        <property type="entry name" value="TRANSCRIPTASE, PUTATIVE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5078519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="549" mass="63365" checksum="DB028F0E69FFC9FC" modified="2022-05-25" version="1">MQATVVLITFTSAYYKKTGTYDWKCQSCKFEVSIIDSDDENEDSGTNISPSAAKTMEELFKKYLAPFSEKISALESSIQSIRLDMNKLAEGGKSTSKHFVQLDKRITDVEKKLSTEGQSLSSDDIIAEIVERQKMKPSDSDVIYCVSESWLNSTISNGEVVEDTFKLFRKDRDSQTSKFARGGGVLIAVHRNITAELVPLNKHNIEQVFIKIKESNGEVIIIGCVYLPPQSTVEIFKDHLDTIHYINNIYPNAKIIIIGDYNIPNSYPPARTDPILEEDVYHPALSIHVSCTASMKLFKEPQYCFKKANYIALNDFFLNTNWLELYNIKTVDEKLLWFYKKIKLGISEHVPVYTNNRSEYPRWFSKELIRKIKLEKQVHKNYKKYRSYHTYKEFQNIRKECKSLSIICYNNYVTRMENLIHEDTTQFWNFVKSKRRKDSNIPSTMNWSENTANTGEEVSNLFASYFKSMYMGTHDSSVNQINKLSQRRQISDLIFAFKIINGHIDSPEIREKVGIICPTSNLRANQLIETIKTTKSYIYIIARGIGSLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H6R7</accession>
    <name>A0A8J2H6R7_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS2937</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001117">
        <property type="protein sequence ID" value="CAG5079145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H6R7"/>
    <dbReference type="OrthoDB" id="6624782at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14813">
        <property type="entry name" value="bZIP_BmCbz-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07716">
        <property type="entry name" value="bZIP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BZIP" evidence="2">
        <location>
            <begin position="437"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="330"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="349"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="371"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="439"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5079145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="506" mass="57326" checksum="A66C801327087078" modified="2022-05-25" version="1" fragment="single">VFKIPPISKRSTASNITFDKGGEFKVQEQCNNTKKQSSASHGVKSQPKVLVPPPQVADDQHALTPIISPTTEKELLKDLMWDTKEPSSSSMNSSPNLRDEDNTTIFSPTWEENYQDLSGWCSRIPMDHRSYSFPVGESLNGRHSDMKIDDQTYSTNVGVDVLNVGMTSATIDLDDFKQQNNITNNNNLNNSNNMNNIIKNNKNVMLPPIDDDKPIMLGGTIDVPDEWLDLPKSSIASRTDEWIRLVDNDKMDEPLQRLEINQLNDNVNLDNSYSAEPTVNWDIIYNFDNNEKDFDLLSYLCDDNLNSPESISTDSIDIYQASTSYINKNKNEGLSTRMHNTRNRKRNYSQDTITSPSKNTDDLDIKPLKPSFASAMSPSTSSSSSGAGSTKATTRAIKPTKTIKTRMKKEVIDSFDTQSRRGRKRQYDSESEGENSDYSYRESREKNNEASRKSRMNKKAKEKGMMMEAVSLEKTNRILKSRVEQLEKMVITMRAAILKSALRRKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H715</accession>
    <name>A0A8J2H715_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Cc_odve66_18</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS2872</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001117">
        <property type="protein sequence ID" value="CAG5078895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H715"/>
    <dbReference type="OrthoDB" id="7672748at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.100">
        <property type="entry name" value="Chondroitin AC/alginate lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008929">
        <property type="entry name" value="Chondroitin_lyas"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5078895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="622" mass="71102" checksum="E9B7B9EDC0C59631" modified="2022-05-25" version="1">MKFQKFLLIGLAAGILVGAITWIIISSRKIQDDPRTIPIKQALILPRVVLSSEFVSLIDANDSNLKDFADHAYPGWDQKTDQLKKLALFAIKLLDFWATYGRKKSRNYPKIAESVVSQVVGKLKQSDMSKVPWGDNWYTFSALVTRMLVMYEYVGDEPDLKRACHDQVIRIIPSVGTTHEILDSEDYNTMNIYFTAVPRLCSNFMFDFNAYNADIKTPAFIKVKKFLSFEEVKVDEPKTGVYRDLSWIHFTNVASYQLLFELYNFHERVYTALGHTNRIRELAEAIIPKILHPQIPYRPLGLSGRNDVIYSRTNYWELVPNSFGVHIMPFIGFGVFKTPEFLFYVRVQRPGIAAYVTNSFETEKIFALAWMQLPKLYFRNYKSFTDYDATLTAKLLMESPGLLLIKGEDYSSNVLSSKNENLKAYHADPGSIDSFIGTVRSSKDRDALFWKNKYKFSAVYGNCTITEIGIVWDTTVTFRLEVHNQSGKELAFRLKTLGHYLSTNVYSINDTIEYYIEGNAVGEVLKIPARGNPVVIQWGFGIQEDNRGTITCPNGRVKFETNCIAFEVQTIENNGNFVVRNEKGNIIAGGSSSSDPEHSFQFENVTLVRNKDNFMYYPSETH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H747</accession>
    <name>A0A8J2H747_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Similar to FRY: Protein furry homolog (Homo sapiens)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HICCMSTLAB_LOCUS3118</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5080848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6287725at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030427">
        <property type="term" value="C:site of polarized growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000902">
        <property type="term" value="P:cell morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031175">
        <property type="term" value="P:neuron projection development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025614">
        <property type="entry name" value="Cell_morpho_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025481">
        <property type="entry name" value="Cell_Morphogen_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045842">
        <property type="entry name" value="Fry_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039867">
        <property type="entry name" value="Furry/Tao3/Mor2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029473">
        <property type="entry name" value="MOR2-PAG1_mid"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12295">
        <property type="entry name" value="FURRY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12295:SF30">
        <property type="entry name" value="PROTEIN FURRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19421">
        <property type="entry name" value="Fry_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14225">
        <property type="entry name" value="MOR2-PAG1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14228">
        <property type="entry name" value="MOR2-PAG1_mid"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14222">
        <property type="entry name" value="MOR2-PAG1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cell morphogenesis protein N-terminal" evidence="2">
        <location>
            <begin position="236"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="domain" description="Cell morphogenesis central region" evidence="4">
        <location>
            <begin position="1336"/>
            <end position="1423"/>
        </location>
    </feature>
    <feature type="domain" description="Cell morphogenesis central region" evidence="4">
        <location>
            <begin position="1573"/>
            <end position="1656"/>
        </location>
    </feature>
    <feature type="domain" description="Cell morphogenesis central region" evidence="4">
        <location>
            <begin position="1824"/>
            <end position="1884"/>
        </location>
    </feature>
    <feature type="domain" description="Cell morphogenesis central region" evidence="4">
        <location>
            <begin position="2108"/>
            <end position="2207"/>
        </location>
    </feature>
    <feature type="domain" description="Cell morphogenesis protein C-terminal" evidence="3">
        <location>
            <begin position="2365"/>
            <end position="2617"/>
        </location>
    </feature>
    <feature type="domain" description="Protein furry C-terminal" evidence="5">
        <location>
            <begin position="2650"/>
            <end position="2857"/>
        </location>
    </feature>
    <feature type="domain" description="Protein furry C-terminal" evidence="5">
        <location>
            <begin position="2914"/>
            <end position="3241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1073"/>
            <end position="1098"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1679"/>
            <end position="1700"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1738"/>
            <end position="1759"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1937"/>
            <end position="2059"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2680"/>
            <end position="2706"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2744"/>
            <end position="2774"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2810"/>
            <end position="2914"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="3139"/>
            <end position="3166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1937"/>
            <end position="1952"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1953"/>
            <end position="1966"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1967"/>
            <end position="1987"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1988"/>
            <end position="2010"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="2014"/>
            <end position="2029"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="2030"/>
            <end position="2050"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="2690"/>
            <end position="2703"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="2744"/>
            <end position="2768"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="2810"/>
            <end position="2829"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="2880"/>
            <end position="2889"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="2898"/>
            <end position="2908"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF14228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF19421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAG5080848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="3271" mass="363830" checksum="FFFE3D11B153B776" modified="2022-05-25" version="1">MSPDNETSIETMAEDMENQLGGDETHSETNDSRAGHGDGSQESGVETLVACPDSLTSHGSVQGEGSDVSSIYTANTSVSGYETSSSRMSAITVVLPWGAQKETVKPQHMEDMDLRPGEFVMRNLFADFAAQAERKIEAVMTDTEKTLSKVLQRGEDAQFDQLLSAFGAVADHCLPSIVRALFRWYERQLADQGIDQKKPASGKEDQKGKSIMYTIVSGSGNVETAPEKSEADLLQERRDLAVEFIFCLMLIEVLRQLPFHPGHEDLVTEIENIAFKHFKYREGIQNEPNATNIHIIADLFAEVIGVLAQSRFMAVRKRFMIELKELRAKEPGPHTTQSIISLLMGMKFFRVKMVPIEEFEASFQFMQECAQYFLEVKDKDVKHALAGLFVEILVPVAAAVKNEVNVPCLKNFVEMLYSTTLDMCTKSKHRLALFPLVTCLLCVSQKTFFLQNWHYFLAMCLSHLKTRDPKMSRVALEALYRLLWVYMIRIKCESNSATQSRLQSIVNSLFPKGSKAVMPRDTPLNIFVKIIQFIAQERLDFAMREIVFDLLSVGRPVKIILTPERMSIGLRAFLVVADSLQQKEGEPPMPRTMGVLPSGNTMRVKKTFLNKMLTEDTARSIGMSSYFPHVRRVFVDILRALDVHYGRPLMMTSTQNMNKEPDEMITGERKPRIDLFRTCVAAVPRLIPDGMTGAELVDLLSRLTVHMDEELRGLAYQSLQTLVIDFPDWRQDVVMGFTQFLARDVQDTFPQLVDNGLRMLLQLLTSWKNALISPSPRAKEQAIESQRINPRIDPAVKKVDTSAQKVEQASTVFHLVEGFALVMLCNCRLYPRRLAVHILREVKVLLKALGGLETDQPVIDVIDASCPAVIEKCYHLLPPAEKAAAASTSNVDLQWIADRSSCVWTAGFHDENSTKSSSLLNLNGVDPWSLCLFAFLERDRVLTLCPNATAHSWPIVFTRINSLFSVVDPTPVNDNRASLLRSSTAVRKPVNERDVYMHIWKNYLTFGYRVVPPIPSPIIRCASPDLSLSGQHTVEFGVLCMSKELSQSLENLGGAQTLPGRFSVPSISGIYTRHKRTSSSPDSLSAERGDNKSPGNNASPAALYKLTVPLLRCEAVDVRDAVVHAIGKVNADALKDLMEELVPYIREAVDRKQENMRRRRRRDALRLQLVRVLELVAEYGTFGICPAVLDRETQSLHPTFVEYIDGARLYLENETDKEALAVRDIKLHFCNFIRKMIKSFSIEACHLLLKRDLRRNLFTLFATWSGPYGKPLTNVSSTFDEDKSCSELQLSALQAMSSLLCCGPCFNPQSLSEEGAILYQWLDLLLASKDEKIYTLARETVVLLLEGNPDIGTLLDWVVDRCYTGLPQVADGCFLALATIFSAREYPCDHYTSVINVSLMNTGCPRVSVQDAALQLLQLLDQRFFGNVRPLPTAELETNQEECPLNSLINPGTTMPGAISSFGTNVPVKAGTLDALLTASYCRNQMYLSRQLAQLHPELTMPMFSEITHRFQTARREVRQLLLQYLLPWLHNMELVDPNVPPPANPSSYYQYYTSDVTRGGTKREGWGTAEATEMVLNNLFYITVKFSDEHPKEVEELWSTLCGCWPNNLKVIIRYLIIISGMAPQELLPYAKRVVLFLARSRPERLVDEMMTELQTVETLNCLIERTETPPFYRLTSMRKASSHSDAPAADPGNPSRDLAVEKGTIHTKRHSGEDPVKTGSKSDTALRALAGFQTPRVEKTRTTSGPPILPDDLSTPTTEVELTTDETIYVTRIGSSVTNKVNHSEKFDIPQPHPLPMPEYGGYFAPLTEYLPDSSQPISGFHRCNIAVMLLTDIVVDGIQLDWAIHVPLMLHIIFLGLDHSRPLVRDHCRMLLMNLLVVLGDHRDHLGVARLLLASRTEQLGLGLSTPALPILEHNFTEVDPEFDAYLYGPPAVAPTATTTTPPRSNTPPAYSPPPAPPLPEPSSSPVLTSSDASPSHSPIPSASVTPPTLLASQAKDQSKEANTSLMGASPPIPPPPPPPPFPTSPSAPTSTSPSPSHSPIPTTSVTPPTPAQVQSKELDNTPLRAWPASAGSSTGVPPVIVTPEDAGNWTGPQPGPNMPIQDVIRSLINFLASKTNQPLWNYEDMTAKVWWVRSAEQLTVLLRHVLRVFRDSLPHAHVSQRWAETALQLGLSCSSRHYAGRSLQVFRALRVPITSRMLSDILSRLVETVAEQGEDMQGYVTELLLTLEAAVDSLESDFRPLDFMKEIFKSTPNLNNKDPASGIILGKRNVGGVCGYPGPHVFTHLNHASGHTRSTSYSVSYCMRKSAAGSTATTSTDPKELDSRVCGNKYPNSNLSRSRSAQSLKLLGDSATQDDKMTILAQLFWLSVSLLESDYEHEFLLALRLLGRVLHRLPLDRPDARDKVEKLQQQLGWNSFPGVHALLLKGCTSPNTYEPVVTLLSQFTPLLDLPFVDPTQNLAFPMNVISLLPYMLLNYEDANELCIRSAENIAQVSAEKGKKLDHLGTVMTLYSRRTFSKESFQWTKCVVKYLYDTYAHLSFNMLAFLVEVLEKGPASIALPVLSIIHCLLHYVDLASKAAQPINTELLRVISKYVEGPLWKEALKILKLVVTRSSTLVAPPTTVHGSSWEPSLTSPHPSFTDTEIFTKKELPGRTMDFTFDVTKTPVIGKRWLKRQVEDEKTAGSPRRSLSLSPADSNAVSSWKRPWMSQGRVRECLVNLLRPFGQPVGLPKSPSVIFSQSSDLMERQSSMASSTEEMSGANNDLSGGSRRDDEQFGVFKDFDFLEYESESVEGESTDNFNWGVRRRPLSEGEEREPSLRQFEESLSEKTLSSNKLTSRRGVAEESSDDEVGSESPLDEVPSGSGTGQEINNIPGMFPPSSLSLIPSRSRHDSSTRSDTSGSSAGDLGDVTPCNASPNLSALMPFRQVVRDDAEEIWRQQIQNLISQPPYNILEFFHLLSRILRDVSSKSVGLSREAVALLTNGSTAASQLASQLSSHAELLSSKAEPPLIWFSLTVFGSQRLSETLRFSMFEIQEHLETFLDKKDHATECLEAVKATNKLQVLGGDSSAGQDQSSEEMHLVLGRAFYKLHFQLLLMIEASNKMLLSLTKASKNVTVQLHDMSVEISMMKTALCRALEESTESERGTPTPTPSPSPLPSGSEDMSRVAEFLRSARWSSALEAVRIHRAQWPSDPFHDDDDVTTAVNMYCRHLGQERSDLFVVTKTDSEMTDIFDRLMESLFRVLAAVTGLEAAVKAVRLPGSHHSKLDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H7C9</accession>
    <name>A0A8J2H7C9_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Olfactory receptor 81</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HICCMSTLAB_LOCUS3422</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5081959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H7C9"/>
    <dbReference type="OrthoDB" id="6614360at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005549">
        <property type="term" value="F:odorant binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004984">
        <property type="term" value="F:olfactory receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004117">
        <property type="entry name" value="7tm6_olfct_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21137">
        <property type="entry name" value="ODORANT RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21137:SF35">
        <property type="entry name" value="ODORANT RECEPTOR 19A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02949">
        <property type="entry name" value="7tm_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0552">Olfaction</keyword>
    <keyword evidence="8 11" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="9" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="38"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="75"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="130"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="198"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="265"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="300"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAG5081959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="397" mass="46172" checksum="57DC8B9B023528BC" modified="2022-05-25" version="1" fragment="single">MSNYLQIKELIAEGVKVFDWANWISVGIGVWPLTPNNYLFNLVFVYFTVVMILEYTDLFVHIDDFASVVDNLSENLALTIVYSYTFSLRFYEKKLAQVFRETLMDYDSDKALKNMKEVKLFMVYTNNAKFFAKYIIILIALTDFVWLFQPLIFMSTFDAGIDIDNKTRSFILPYHFHICYKLDDFKTYALTYLWQSPFAAINCFGISSFNVFLLILVFHVSGRMAVLTGRIDELKFEKVNFQRKLNEIIIEHIRILNLGSKISDIFAAPLLIFFVLTNLLLCISVYQILLNIMTGLNTNILQYIVLLITVYLMLYVICMNGERLSDEGNKISQSFYNCTEYNFHDIKSKKKIIFSLLRSQKPLTLKAGKFSDFNYETLSNITKSAAGYLSILRKLLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H824</accession>
    <name>A0A8J2H824_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS3895</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5083649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H824"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5083649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="95" mass="9885" checksum="2515D6E46601308C" modified="2022-05-25" version="1">MEAAVGTFGTINRSASFFIYEVSLSGTRIGGWLFRIVTIGLYSLLFDNPLLPFSAPTSTLSGISSSGLPSATTSLEAPKIASAATYGKMKLSSEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H8A3</accession>
    <name>A0A8J2H8A3_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Mitochondrial (Homo sapiens)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HICCMSTLAB_LOCUS3771</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the thiolase-like superfamily. Thiolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5083224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H8A3"/>
    <dbReference type="OrthoDB" id="5404651at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003985">
        <property type="term" value="F:acetyl-CoA C-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00751">
        <property type="entry name" value="thiolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020615">
        <property type="entry name" value="Thiolase_acyl_enz_int_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18919:SF107">
        <property type="entry name" value="ACETYL-COA ACETYLTRANSFERASE, CYTOSOLIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18919">
        <property type="entry name" value="ACETYL-COA C-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00098">
        <property type="entry name" value="THIOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiolase N-terminal" evidence="4">
        <location>
            <begin position="3"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAG5083224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="174" mass="18931" checksum="4C7BFBC3FCD4D028" modified="2022-05-25" version="1" fragment="single">SSSDGALLARHVLLKSEIPIEKPALSVNRLCGSGFQSIVNAAQSITSGESEIVLAGGAENMSQTPFVVRNVRFGTMLGQKIDFEDALWVGLADSYCNLPMGGTAEKLGAKYGVTREEVDQFALRSQQRWKAANDAGYFKAEMAPVSMTIKKKQIEVSVDEHPRPQTTIEDLKKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H8E2</accession>
    <name>A0A8J2H8E2_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Similar to T: Transposable element P transposase (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">HICCMSTLAB_LOCUS3037</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the THAP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001117">
        <property type="protein sequence ID" value="CAG5079538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H8E2"/>
    <dbReference type="OrthoDB" id="7592187at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.210.20">
        <property type="entry name" value="THAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026516">
        <property type="entry name" value="THAP1/10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021896">
        <property type="entry name" value="THAP9-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006612">
        <property type="entry name" value="THAP_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038441">
        <property type="entry name" value="THAP_Znf_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048365">
        <property type="entry name" value="TNP-like_RNaseH_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46600">
        <property type="entry name" value="THAP DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46600:SF1">
        <property type="entry name" value="THAP DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05485">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21787">
        <property type="entry name" value="TNP-like_RNaseH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12017">
        <property type="entry name" value="Tnp_P_element"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00692">
        <property type="entry name" value="DM3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00980">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50950">
        <property type="entry name" value="ZF_THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8 12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="THAP-type" evidence="13">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CAG5079538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="600" mass="69310" checksum="2A7919858BFA4CEB" modified="2022-05-25" version="1">MVRCNVKGCLRRPEIDKDHSFFLWPKEERIRQQWKNFAQYKGFSNSLRICSDHFERRYIKKNTPPKRLLVSNAVPTLLPPDNILKMPKNMPKSPLTNSTAKNLLVNVNNDEVIFERPALKDECSHNDRGITFEVRKATDTEPALINIETNSFVKISLRDEREIGKSTEPQNPEAVIQPTDSKELKFNAAEKLFNSVEAASQNDTNMPILLTNSEELKSKAALEELPFNNRAETLNLNISPETPAQYSTPKKIHKFMRKFKLFSKKTPCQIIRSPKNAVSSKVIKIEMLTPKSLRLHKGARTIGRLRSQINRMEKKFAVKEKMKQDVESIINASSNYLSKKALVLFAAQLRLSVKNKYAKRYSNEVKDIALSIKYHSPKTYKLLAKFLHIPTIRTLNEYQKDFPTTPGLNFTVLNQLKDTFAKNNIEDRLVSVLFDEISLATEVHYDAAKDMFHGYADDGEKRSNEIAHCALVAMITRINKPMKQMIGYWFLGKKGNSAKTHKIMVNTIEKLNETSLIVKCLICDQGTRNTGLIKKYKITQDKPFFEFTVGDEKRKIYIIFDPPHLIKSFRNNLFNKRFKYRGGYVDWKLIYKVYLLSITK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H9C5</accession>
    <name>A0A8J2H9C5_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Similar to Y105C5B.9: Phytanoyl-CoA dioxygenase domain-containing protein 1 homolog (Caenorhabditis elegans)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HICCMSTLAB_LOCUS3480</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the PhyH family. PHYHD1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5082186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H9C5"/>
    <dbReference type="OrthoDB" id="445007at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008775">
        <property type="entry name" value="Phytyl_CoA_dOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20883">
        <property type="entry name" value="PHYTANOYL-COA DIOXYGENASE DOMAIN CONTAINING 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20883:SF15">
        <property type="entry name" value="PHYTANOYL-COA DIOXYGENASE DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05721">
        <property type="entry name" value="PhyH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAG5082186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="284" mass="32788" checksum="01BE439BCB41F769" modified="2022-05-25" version="1">MKDIQLQLEKDGYVVLEDFFSPEEVEEMKACGEDFTNNLPPENQRKVFNTIELQQNKDEYFMDSAHKISYFFESESLEDNGKLKVHPRVSLNKVGHALHWLHPTFKRVTFDERIKETAFQLNFQEPAVCQSMYIYKNPGLGSEVIAHQDASYLHVEPMKLVGFWIALDDATLENGCLWVAPGSHKSGVHRRYIRNKDYPESSKDILIYDRGTPCYPASNFRAVPVRRGSCILLHGLVVHFSKANKSDKSRHAYTFHVIETKLTTYAKDNWLQPPEGGFPLLYKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H9V8</accession>
    <name>A0A8J2H9V8_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glutathione S-transferase Delta 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HICCMSTLAB_LOCUS3600</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5082580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H9V8"/>
    <dbReference type="OrthoDB" id="2309723at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03177">
        <property type="entry name" value="GST_C_Delta_Epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1050.10:FF:000007">
        <property type="entry name" value="Glutathione S-transferase 1-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43969">
        <property type="entry name" value="GLUTATHIONE S TRANSFERASE D10, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43969:SF9">
        <property type="entry name" value="GLUTATHIONE S TRANSFERASE D10, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13410">
        <property type="entry name" value="GST_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02798">
        <property type="entry name" value="GST_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00358">
        <property type="entry name" value="Main_(cytGST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST N-terminal" evidence="2">
        <location>
            <begin position="12"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="3">
        <location>
            <begin position="90"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG5082580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="217" mass="24761" checksum="D6879733BA0DBEFE" modified="2022-05-25" version="1">MASSKECSKSKVQIDLYYRPGSPPCTAIRLVAAALGINLNLTLIDFQSGESLKPEYLKLNPQTNIPTMVDDGFSLWERINTEKMTLCTRKTPKHELVDQRLYFDFGTWSEAFTDYFYPILFCGAPRDQSKYDKIAVGFDLLERFLEGQNYVAGSQLTIADLALIVTVSNLEVIKYDFSRYKNVNRWATRIKAEAISFEECNGEGLKAFQELIDYLTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HA07</accession>
    <name>A0A8J2HA07_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS3705</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5083004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HA07"/>
    <dbReference type="OrthoDB" id="7691576at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37162:SF1">
        <property type="entry name" value="BED-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37162">
        <property type="entry name" value="HAT FAMILY DIMERISATION DOMAINCONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5083004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="582" mass="67475" checksum="37B374526FF30800" modified="2022-05-25" version="1">MVEQNLKIEKENTAEEKILIALRDRLGKLKKNSVGKYLFVLNPGSIIIPVSPKKIIKYSSIMSDISSDEDTPPKRLQAKKLKLYTRRKQKFLKEWLNNTNFNTWLMPDLSDKYKARCKLCNVTFTAELTVIKNHGKCKHHMSAMNSASNQKLIRTFTQKNAEPSFDYNATRAEIKLCGFLAEHNLSFRLMDHLTPLLKDCFPDSKILQDMRLKSSKSAAVVVNVIGATEKSMHCRRVTSCFWELYQVFNEEDNSSEASAQHIYNCIEKSFEKYSIPLTNIIGFGSDGCSTMMGDKNSVRTRFEQSCPGIYIMKCLCHSLHLCASNACSELPAECEKLPHLKEIQSILALKAHKILRPAQTRWLSIRAVVERLLEQWDGLFLYFNKLYFEEECKNMNKKKKDASDQIATEENKSDVARILRCLQNPTMKLYYHFLLWSLPKFTDLNKLFQSEKPLITAVHKKMSLTYLDLLKTFMDDKSYQYNYINMTSLKDINPSNEAKFKNIHNIYVGIEAFNYFNKPESTKPPLLEEKINFLTNCRKFLIRGCEEIKKRFDFDDLIQKNLSVINPREAMNKKTVMTMPSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HAA4</accession>
    <name>A0A8J2HAA4_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SOCS box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS5542</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5090225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HAA4"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5090225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="270" mass="30785" checksum="5F62D610C02A11E7" modified="2022-05-25" version="1">MVDELLARKVNLKATTTSVPPPLQFAVEGCRMTSVQKLLAAGADVNHYYGPDEDLPLVRAINNLRPDMIKLLIRHVTEPSEGWITTPLMSACHAKAPRSIEFLINLPNIDISKVNNKNETCLFMNVNGLDAAGLELILNTNIECRGILDKDAETGPIQAECFREVQLMMNTYEPSINWSFFRILRVSQHLLTLRFKNIQVPAGNEEELIENFPIYGRMLAFHMKKALQRKVLFEQAEEVLLVIFRKLLPATVINEIIFFLTNYDLYKLKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HB42</accession>
    <name>A0A8J2HB42_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Similar to ash2: Set1/Ash2 histone methyltransferase complex subunit ASH2 (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HICCMSTLAB_LOCUS5618</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5090403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HB42"/>
    <dbReference type="OrthoDB" id="10266026at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048188">
        <property type="term" value="C:Set1C/COMPASS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15583">
        <property type="entry name" value="PHD_ash2p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12872">
        <property type="entry name" value="SPRY_Ash2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.980.20:FF:000005">
        <property type="entry name" value="Set1/Ash2 histone methyltransferase complex subunit ASH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.980.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037353">
        <property type="entry name" value="ASH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049455">
        <property type="entry name" value="ASH2-like_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053835">
        <property type="entry name" value="ASH2L-like_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10598">
        <property type="entry name" value="SET1/ASH2 HISTONE METHYLTRANSFERASE COMPLEX SUBUNIT ASH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10598:SF0">
        <property type="entry name" value="SET1_ASH2 HISTONE METHYLTRANSFERASE COMPLEX SUBUNIT ASH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21198">
        <property type="entry name" value="ASH2L-like_WH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21257">
        <property type="entry name" value="PHD_ash2p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="B30.2/SPRY" evidence="7">
        <location>
            <begin position="319"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="248"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG5090403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="559" mass="62798" checksum="F0C8623584377081" modified="2022-05-25" version="1">MMSEEKINPMTEKPDEIIPIVSNNKLQEVTEDAEKKKLSTEGNGDKLNRLVSVNSNGNAIANDNINCYCGKDRNLTIAELLCAGCSKWFHESCVSYQLGKLVPFMMNYVFMCKNCSSSGIESFKKIQAQFPQMCVTAIANLSQLAQRDPEQRMLFHKDRDIIPFIECNWESMTTMPRRVTQSWHGTIHKTLLKDIGTLFTIDENNTDGQLFGLTTPDLVLIKPNYEAMIKGGQIKITEMGVQHIAPVTPGIRGRNAKRKLPGEGSGAGPGKKGRGSDLSTPKLPAHGYPLEHPFNKDGYRYILAEPDPHAPFRQEFDESSDWAGKPIPGWLYRALSPSIVLLALHDRAPQMKISEDRLAATGDKGYCMVRSTHSVSRGTWYWEATIEEMPEGSATRKGTRFHESRGKHYSSGYGEGDTLGFLIVLPDTYDASHIPNPYKDRPLVKFKSHLYYEEKDQVPEALKALKPLHGSKIIFYKNGEYQGDAFIDMYRGAYYPTLSIHKNATVSVNFGPNFKCAPSNVNFRGMCDKAEETMVEQSMADMLYLNENDGKLRLDTFTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HB47</accession>
    <name>A0A8J2HB47_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transposase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS5633</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5090445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HB47"/>
    <dbReference type="OrthoDB" id="8184047at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009667">
        <property type="entry name" value="DUF1258"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579">
        <property type="entry name" value="F5/8 TYPE C DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579:SF1">
        <property type="entry name" value="F5_8 TYPE C DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06869">
        <property type="entry name" value="DUF1258"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="852"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5090445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="852" mass="98160" checksum="16AB393C8EB84CFF" modified="2022-05-25" version="1" fragment="single">RNEDNNFIHEQLDVYVDVNNRIPDDNVVDNVLNQPLDVNVVNINDSNNDDGHDENRQNGELDDHLDMNNGIGNDNDLLHEQMDYVAQGGEENDQDEIEEPLNENEDTDESEDEADEDDSDEEGDNDERNFDYEQLLYPGAPLTVSQSMSLILSLLVRHNVTQTCLGDIITVINLHCLQNNNNGFKNSLHKFRKFFSLSKKGTVKKTKHFYCVSCQKNLENENDICGNCELSKKAYFIEVPVRQQLIELYRRPGFYECLQHRFNARLEDNNHYTTDIYNGSLYQSFVANGFLANQDNISLTWYTDGIPVYKSSKVSMWPVYLSINELPFVERTKRQNLLMIGLWFGPQKPNANNYFYKFYKQFKTLSRGINVTVSTNDIKNIKAVLLFGTCDLPAKCQFFNFTYYMGSYGCPSCLWPGETYRLGEDGNSHTHVYRYTPDPEMRTSRECVAFAETALNENSPHMGVKGPCALSKLMPDFVVGTAIDQMHCVFGGVVKKLLSLWFDSSHRGEPYSLVDTANIINDRLMSIKPPSFVHRMPRSTEDLVHWKASELKNWFFYYALPVLEGIMQREYFENFSLFVAGISLLNSDSITNNDVIIACNFLHKFVREFEILYGLKHCSINVHLLIHLPKCVQALGPLYATECFQYEDLNGQYLNVINGTRHIDSQVVRSHNQQLKLQRFFDELPEGKIKEFCMKHKHNSKIGERIQESCYSIGCYKVFNDNYIIPNNVQHALENLLPAQKIYEYLRDQTGYHLGSVLCFVKLSYCECLNLHNCPNHRPSVHQAIVENIVGERVFLVRGDHNVQYELPYMFKCTKMNNFVSISIDQLISVCFEIKIGNDLHIAIPVNSNSNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HBK6</accession>
    <name>A0A8J2HBK6_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Similar to dmsr-1: G-protein coupled receptor dmsr-1 (Caenorhabditis elegans)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HICCMSTLAB_LOCUS5055</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5088989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HBK6"/>
    <dbReference type="OrthoDB" id="5864054at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008528">
        <property type="term" value="F:G protein-coupled peptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14978">
        <property type="entry name" value="7tmA_FMRFamide_R-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019427">
        <property type="entry name" value="7TM_GPCR_serpentine_rcpt_Srw"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053219">
        <property type="entry name" value="GPCR_Dmsr-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46273">
        <property type="entry name" value="MYOSUPPRESSIN RECEPTOR 1, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46273:SF15">
        <property type="entry name" value="MYOSUPPRESSIN RECEPTOR 1, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10324">
        <property type="entry name" value="7TM_GPCR_Srw"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="65"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="104"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="152"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="222"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="304"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="7">
        <location>
            <begin position="46"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG5088989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="346" mass="39795" checksum="04612B3506887678" modified="2022-05-25" version="1">MNLTNETYSQNISMFQCGPELDHFHQEYVKMHGWLSLLVCIFGSIANTLNIMVLTRREMISPTNYILTGLAVADLLVMLEYIPYASHMYLYHRPRKDMYTYGWAVFVLVHSIFTQIFHTISIGLTVTLAIWRFIAVAYPRRNNEWCSIKRTVLTILGTYLICPLICLPVYFTTKVRSTQELFDPNDNLTNSSLYNSTELKVNQTLWFVDLSDTMKANSLLNLLNFCMYSVVIKLIPCIALTILSLRLIKALMDTKKRRKLLINATLVRKTDDKVRDSSCDVKKSKKKSAKAIDKQRQTDRTTKMLLAVLLLFLLTEFPQGVLGLLSVILGSGFFRTCYVKLEGMLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HBW4</accession>
    <name>A0A8J2HBW4_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Similar to ZMAT5: Zinc finger matrin-type protein 5 (Homo sapiens)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HICCMSTLAB_LOCUS6610</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5093134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HBW4"/>
    <dbReference type="OrthoDB" id="2417221at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.1190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041367">
        <property type="entry name" value="Znf-CCCH_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18044">
        <property type="entry name" value="zf-CCCH_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="5">
        <location>
            <begin position="17"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="4">
        <location>
            <begin position="17"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAG5093134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="133" mass="15283" checksum="6862A5F3D3FDC5BB" modified="2022-05-25" version="1">MKTRFSKNGPKDILKDEACKIPCKKFFTSGECVFGNNCKFSHYSALEIQALEKIVTWRNQTQSEISVEDGRQAHDIMNEYFQHPVVTACKEVIYPAWNITSALKTYENSSPSLSLILPQHITDSNFEKWGFKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HDH1</accession>
    <name>A0A8J2HDH1_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Phosphatidylserine synthase</fullName>
            <ecNumber evidence="12">2.7.8.29</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Serine-exchange enzyme</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">HICCMSTLAB_LOCUS7887</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes a base-exchange reaction in which the polar head group of phosphatidylethanolamine (PE) is replaced by L-serine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + L-serine = a 1,2-diacyl-sn-glycero-3-phospho-L-serine + ethanolamine</text>
            <dbReference type="Rhea" id="RHEA:27606"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57262"/>
            <dbReference type="ChEBI" id="CHEBI:57603"/>
            <dbReference type="ChEBI" id="CHEBI:64612"/>
            <dbReference type="EC" id="2.7.8.29"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 12">Phospholipid metabolism; phosphatidylserine biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Endoplasmic reticulum membrane</location>
            <topology evidence="1 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 12">Belongs to the phosphatidyl serine synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.29" evidence="12"/>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5095796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HDH1"/>
    <dbReference type="OrthoDB" id="10265393at2759"/>
    <dbReference type="UniPathway" id="UPA00948"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106245">
        <property type="term" value="F:L-serine-phosphatidylethanolamine phosphatidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006659">
        <property type="term" value="P:phosphatidylserine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004277">
        <property type="entry name" value="PSS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15362">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15362:SF15">
        <property type="entry name" value="PHOSPHATIDYLSERINE SYNTHASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03034">
        <property type="entry name" value="PSS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="12" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="9 12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="11 12" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="61"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="94"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="125"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="238"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="305"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="344"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="378"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="408"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="444"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="456"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU368094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CAG5095796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="472" mass="54446" checksum="3430D446951E603B" modified="2022-05-25" version="1">MASTEESNEIHLRNRLGKNEDSGVVNSFGSMDIGRGHRLRSETDSFPIINERPVDDISIEFFYTPHTLTLLFLSISAVIYFAFVRDNHDVDDNLWAGMLCVIFFFLIISVLTFPNGPFTRPHPALWRIVFGCSVLYLMFLLFMLFQSYETVRKILVWVDPGLAAFHIDMDKEYGVNCSDITVEKIWNHLDIFAVAHFLGWVFKAVLVRHLGLLWATSIMWELTEMAFAHLLPNFVECWWDAVILDVAVCNALGIWVGLKICSILEMREYKWVSIRDIESTSGKLKRVVLQFTPASWTSVRWLDPYCTYMRFVALCQLVIFWQISELNTFFLKHVYEFPPSHPFVVSRLLLVGVIVAPSVRQYYMYATDPTCKRVGTQCWVYGAIMVTEALLCIRHGAELFERTQAVNIIVWLLCQTLISVLCVYGCVLWHQYFEKGNSALTRDITPTTPESSGILEDTKKQSMDNREDKKEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HDN6</accession>
    <name>A0A8J2HDN6_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Similar to Cdk2ap1: Cyclin-dependent kinase 2-associated protein 1 (Mus musculus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HICCMSTLAB_LOCUS7358</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CDK2AP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5094032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HDN6"/>
    <dbReference type="OrthoDB" id="9628807at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017266">
        <property type="entry name" value="DOC_1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22607:SF3">
        <property type="entry name" value="CDK2-ASSOCIATED PROTEIN 1, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22607">
        <property type="entry name" value="DELETED IN ORAL CANCER 1/CDK2-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09806">
        <property type="entry name" value="CDK2AP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAG5094032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="102" mass="11327" checksum="00DFE41239534452" modified="2022-05-25" version="1">MNMEGELTKLPAGTTITKIIESPITVPNPRNIQSTVPHVTVTAIPGQSKYVQLLNVIEELGRDIRPTYAGSRSSAERIKRGLVHARLLVRDCLHETERSARQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HDW3</accession>
    <name>A0A8J2HDW3_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similar to RABL6: Rab-like protein 6 (Homo sapiens)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS7771</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5095563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HDW3"/>
    <dbReference type="OrthoDB" id="207081at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040385">
        <property type="entry name" value="RABL6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14932:SF1">
        <property type="entry name" value="RAB-LIKE PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14932">
        <property type="entry name" value="RAS GTPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08477">
        <property type="entry name" value="Roc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="299"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="384"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="507"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="299"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="384"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="415"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="547"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="564"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="581"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="619"/>
            <end position="630"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5095563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="668" mass="75242" checksum="42A9C994DAE486C4" modified="2022-05-25" version="1">MLSAFKRLAGKHDGVVNTSPRPAHQSMPTTLQRKFSKGVQYNMKIIIKGDRNVGKTCLFHRLQGQKFTEEYIPTEEIQVTSIQWNYKTTDDVVKVEVWDVVDRGRRRRKLDGLKMDNAPSDAIIEEPALDAEFLDVYKGTNGVIVMLDVTKSWTFDYVQRELPKIPDHIPVIVLGNHCDMSHHRTVTSDRVTYFIDSLTERTAQVRYAESSMRNGFGLKLLHKFFNLPFLQLQRETLLKQLETNEEETQLTSQELDLFQESDDADYDKFLDNLVNRRRAVAESVSANILVPNVTSSLSTHHALSSSNSNNNFNDVRRSNSMPGPIGGGTPIPVKSFEAKVIPKKETKTDYNGKNIISDDKKEKQQNFVAKILAGKKDDVPTINLTNAANNKNSSPLASVEDFVPDDGMLDRSFLDDNNQSPQKTQASSNVVDTDSETETANPLVAGYEDDLSSADDDHSVPVEPRLAENPLSKSKKRDAGSLIEDKKIIPEKRDSISSIEELQISNGDFGSLDHQDGNSDRFNSWLSRDSKWRQSPEGGEDVSSTGTRKDKLDVSDKSLDVSVTSSNVHLELLDNSSVRQNYAYANSNSNSNSPVMKEKKKRDKGEDKEKRKKKKSKDKSKDKDKGDKSERRKKRSQRKDEDEGKDELEEFLNGPASRPSIDMAYEAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HE80</accession>
    <name>A0A8J2HE80_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">small monomeric GTPase</fullName>
            <ecNumber evidence="5">3.6.5.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">HICCMSTLAB_LOCUS7709</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.2"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="17">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasmic vesicle</location>
            <location evidence="3">Phagosome membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <orientation evidence="3">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.2" evidence="5"/>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5095439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HE80"/>
    <dbReference type="OrthoDB" id="1436450at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030670">
        <property type="term" value="C:phagocytic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003925">
        <property type="term" value="F:G protein activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000360">
        <property type="entry name" value="RAB9B, member RAS oncogene family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47981">
        <property type="entry name" value="RAB FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47981:SF1">
        <property type="entry name" value="RE17845P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="16" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="12" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-0636">Prenylation</keyword>
    <keyword evidence="11" id="KW-0653">Protein transport</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00047660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="CAG5095439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="231" mass="25519" checksum="D884974294126918" modified="2022-05-25" version="1">MSGSNSLTATSPRSATAPNRNSQKSTLLKVVILGDGGVGKSCLMNRFVSNHFDEHSFHTIGVEFLNKDIEINGEAYTLQIWDTAGQERFKTLRTPFYRGSDICLLTYAIDDRTSFRNLALWRSEFLYYADVQEGSLFPFIVVGNKVDVAESEKQITTEEARAWCAENGNPPLVETSAKNATNVEAAFGAAVAAWAKLEARLERPIVEDTIDLSKQHSPQRTSCCMPLSSAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HG77</accession>
    <name>A0A8J2HG77_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Similar to Lar: Tyrosine-protein phosphatase Lar (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HICCMSTLAB_LOCUS7282</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5093956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HG77"/>
    <dbReference type="OrthoDB" id="10253954at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098609">
        <property type="term" value="P:cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000023">
        <property type="entry name" value="receptor-type tyrosine-protein phosphatase delta isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44170:SF6">
        <property type="entry name" value="CONTACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44170">
        <property type="entry name" value="PROTEIN SIDEKICK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Ig-like" evidence="3">
        <location>
            <begin position="6"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG5093956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="104" mass="11420" checksum="5468A0553A399BA9" modified="2022-05-25" version="1">MFTGPPKILMRPRSQHVKAGGIASFYCSAHGQPPPQIHWRKNGKKVSSTASRYSTKSYANGALLRIDPVRANRDEAMWECVAENGVGDAVTAEAQLTVHERKSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HGU3</accession>
    <name>A0A8J2HGU3_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS9761</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5100688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HGU3"/>
    <dbReference type="OrthoDB" id="7707410at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5100688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="151" mass="17443" checksum="91C49CFB700D9BE0" modified="2022-05-25" version="1">MASDAYNIREDESLKHCTCLECQLISIEFPDGAALVPFNSMLSSINYWRRQIHPPQPKSLNEYVSYLQMDRWKNYLSRTKSELQLKYIQSSDKSSAVVLADKEYLRTIKTSHLLIDATYKVCPRAPAEIYQLLTIMALHILISRASRQISN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HH99</accession>
    <name>A0A8J2HH99_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS9267</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5099853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HH99"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5099853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="139" mass="15359" checksum="75F95F31629BE9E6" modified="2022-05-25" version="1">MRMARSSLSDPALAYQSIGPGSSPAYTNEYFQYLSVLYCSAQEIKRVPISKSLIVVILKSFFIIPIRGIFTLNYKKSLIVVTLKIIAGTLHTYALRNSRLKSELNAHTVLFKCEEATRKSIHSAGDSRALEPSSALSST</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HHG1</accession>
    <name>A0A8J2HHG1_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transposase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS8337</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5096692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HHG1"/>
    <dbReference type="OrthoDB" id="8191915at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579">
        <property type="entry name" value="F5/8 TYPE C DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579:SF1">
        <property type="entry name" value="F5_8 TYPE C DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="12"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5096692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="776" mass="89632" checksum="02F4BF7BCE30AB17" modified="2022-05-25" version="1">MFHDEEQIQEVTHENIDIDNKNPSEPTGNENDVTVERNPVNTAVNKERGHDLKEIPINQLISNLLVMAIKWRYNTTHTLAQEILKLVNISSKINNSKSSKYYWKIILDRYSQHISTHYICDNCGNYLGCEANRLDCCDSCHLEVDYESNKGSFLCIPLGDQLKDLFERTDAHNLYSKNRKKINRYAIEDIYDGKMYKKQVLDDDMISINFNLDGALIFEGSNTSVYPVLCTINELNPYERRDNILLSSVWFGVSKPKNMNSYLKPFATEAKTLVQDGFTYSYKNQTYKKRVVILMGICDSVARSLVRCSTQFNGEFGCGLCLNPGKSVKKGKGYARVYPMINGNPFGEGLRTHEETLLHAEQKTKAKRKGIKKVSVLCEIPNYDIINNLDVDWMHCVGLGVVRQFGNLWFDKTNWDKDFYFGDIIDLVDSFLTSFRPTSDISRTPRPLSDRVHMKAHEWITFLLIYSLPLLKMFFPKKYLDHWALLVEGISILVKKSIMKSEEKYAAKCLNNFILGVESLYGEEYVSFNVHLLAHLPTSVENWGPLYTHSAFIYEDFNQTIQAYVNSPNGVEIQICDSFRLKCVIDRLICLCWDNLDYRQREFLTNLLKRRNKPVSKLQINNCNVLGKPKVLSKLTANQYLAIERANIEVNQVGSIFTFNRCIINNEILTSKNYCREKKRVNYVVMLQNNQIFEINSFIGFKSDSCQQSYLLGFYYSLKNEPFLEDMKLDHLVMLNKKTGTLTAFALNLPRLIIVKSESKFQTSFQFEDLLKSNEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HHM8</accession>
    <name>A0A8J2HHM8_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS8461</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5096939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HHM8"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5096939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="247" mass="28650" checksum="2FABBD28BC0DC985" modified="2022-05-25" version="1" fragment="single">MAQHNLIEALKDLVDTIATSYADLLGEQLTDEHHQTCSRVCNDTIEYFNTILLDPGTTIQVRRSVQAHINQLNWFADQFSRLGNQVIGGDLNQGVKWQNLENAFAGNIQTGCVINQRHKDPASFLQVSRDIIINKVQSVLRDLAGLKVNVEFFCTFRKHQQDIEERKSFMTKSRKILPATSLQDWYTEHVYEKLKHVNYTNNLDNIEFVYHFAWIHNLSGLITSQISLGRHKLYFCDRCLNHFKLEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HHR8</accession>
    <name>A0A8J2HHR8_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Similar to TRIB2: Tribbles homolog 2 (Homo sapiens)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HICCMSTLAB_LOCUS7946</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. Tribbles subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5095914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HHR8"/>
    <dbReference type="OrthoDB" id="410920at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031434">
        <property type="term" value="F:mitogen-activated protein kinase kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032436">
        <property type="term" value="P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000153">
        <property type="entry name" value="Tribbles homolog 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024104">
        <property type="entry name" value="Tribbles/Ser_Thr_kinase_40"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22961">
        <property type="entry name" value="SER/THR PROTEIN KINASE-TRB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22961:SF13">
        <property type="entry name" value="TRIBBLES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="3">
        <location>
            <begin position="68"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="329"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG5095914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="349" mass="38739" checksum="2CCD30FC9A17E165" modified="2022-05-25" version="1">MRLANRQHPLNLTVTRINNGKFLVNPNGHQEVNQPNCNDNQEPAPVSPVVFPSCEFVPTTQHGPTILGDRFLLVGPAEGSALYRCVDIQTGQQLVAKQLTASDKGGEALLQAHMRLEGTGAASAVAGIVDAGRDKKYLLLEGHHGDLHAYVRARRRLREPEARRLFRQVAKAVATCHENGVVLRDLKLRKFVFADEARTRLRLESLEDAVIVDDDDDKLTDRRGCPAYVAPEVLRSGRAYSGKAADIWSLGVLLYTMLVGRYPFNDAEHASLFAKISRGLFSVPDLFSARARCLIQAILRREPSERPDAPDLLRHPWLSKPLLSSSHITGKMSNHDQIVPDNQTNRSQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HHR9</accession>
    <name>A0A8J2HHR9_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Similar to U-scoloptoxin(01)-Cw1a (Cormocephalus westwoodi)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HICCMSTLAB_LOCUS7995</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5096009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HHR9"/>
    <dbReference type="OrthoDB" id="6514762at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.140.10">
        <property type="entry name" value="Chitin binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002557">
        <property type="entry name" value="Chitin-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036508">
        <property type="entry name" value="Chitin-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052976">
        <property type="entry name" value="Scoloptoxin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22933">
        <property type="entry name" value="FI18007P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22933:SF43">
        <property type="entry name" value="LP10131P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01607">
        <property type="entry name" value="CBM_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00494">
        <property type="entry name" value="ChtBD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57625">
        <property type="entry name" value="Invertebrate chitin-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50940">
        <property type="entry name" value="CHIT_BIND_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035289606" evidence="2">
        <location>
            <begin position="20"/>
            <end position="984"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="3">
        <location>
            <begin position="93"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="207"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="237"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="357"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="463"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="208"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="240"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="376"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG5096009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="984" mass="110704" checksum="B1E76E84F4127294" modified="2022-05-25" version="1">MMRLVSSFVILIVCQKIHGLDPITKDDTPRKNHAHRRAVDGSRGNKYYEPAVHDSFDIYDPYDEETDLSDYRINVPGEPGVDYPSYTRIPQTSFTCERQFRGYYADEEAGCQLFHVCDGNFLVSSFLCPIGSTFSQRYLTCDWWNKVDCSATKSFYQKETSSTSEVIDDDDEYLRKAYEMTSLQSSGNGVSAEPQDTPIDQLINETPHVNDLHSSERFPDYSNDRSLDYSQYKYSSRYTNSNSASGNRGRNSRYYSQQSSDSIENNNGNSDNDDDDNNNNNNYNDGDDQSSIKIHTIGRDRKDQINTRYNDFRPSYAPTVPTVTTTTRRFYSPTIPTIVRSTPSRSRHDLEFESSDHLYSAKGKNRGRITPPRPLTTTTTTTTTTEKVTSVTPASIKSTSSFILEVPPILKEDGSFKLNKVSFPRPAIRLRAKQNDDISTERSNSISEFSTIDLNPFSIFTSTEKPQQASESTEVNAYTRVSGTEKSQRVSEISSIEFYPYNDNSTDEQSNSLEQNDRAITRPSSSILPPFYYYSNANQHDNVLLEKSEELGNHSLLLSTPSLTSSSLSPSPTTSSPEIINIPTTLSWFQTTLESPVTDVIPLLKNEVEIKEQAYTTTVKSVEKSSSSIINTTVMDLQREIIEPPSIIFNPPLIHSLIEIENSTYPPESYEYTLVDNKNVHISTASGEESSTISDLLLSSFENNPAKDSFEEVEDAAVGESSPVEVTLTVNNDEDLDPTGELIRSLIAQHDPTSSDSIRDIEILRSNSRPSSIIDNYRRNKVVTAATADNRIKQRSRTRARVNTEPTTYSVKRRNKLKLRAEDSSTDNLPRPFSLSPPSYSSDVTLPTVDFIEPRPVHPSRIRNTETVVKDNYEIGNTKHEGLLQSSHTLFDLPKQDKLSDFQGSHNLPQKFEKNSKPVIQKNETKVETEGKVLVETQLVPALGFSLNTDEEREKFAHAVLHGLFSDVSAESNVKKKMDGDLKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HII7</accession>
    <name>A0A8J2HII7_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Olfactory receptor 211</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HICCMSTLAB_LOCUS11018</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5102444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HII7"/>
    <dbReference type="OrthoDB" id="6597368at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005549">
        <property type="term" value="F:odorant binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004984">
        <property type="term" value="F:olfactory receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004117">
        <property type="entry name" value="7tm6_olfct_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21137">
        <property type="entry name" value="ODORANT RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21137:SF35">
        <property type="entry name" value="ODORANT RECEPTOR 19A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02949">
        <property type="entry name" value="7tm_6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0552">Olfaction</keyword>
    <keyword evidence="8 11" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="9" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="34"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="67"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="121"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="162"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAG5102444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="360" mass="41196" checksum="5FD8492ADEE69D2A" modified="2022-05-25" version="1" fragment="single">MTTAVLSHSLFILTLVGLWRPIDWRGWKSLLYNSYTYFVAFANFAFILTELVDIVTNSSSVNDLTNGLTKIMGQLGAFGKVVGIMLNRKMILQGIKLLELKPFKLEDQDEKNIILKSYITFLYLAVFTIGALGILSSQMSVMEFPDVLPYRAWFPYNYSKPILFQTTAAFQLFTFFIGAYVHVAFDTLFLRMMLCVVVQISVLEHRLEIIISSMKKLVTNNINLSKDEVNTGDMLIEEWSIFLQYCLSSTQICVSVYTISNVPFLSGVFMSEVPFLIGTIMQIFLLCISAHHVTLEFDDLNYSVYSVEWFDLNTYLQKSISIIISKTMKPVIFKSGYFVTLSLESFKQVMKLSYSIYNLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HIM2</accession>
    <name>A0A8J2HIM2_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS9612</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5100539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HIM2"/>
    <dbReference type="OrthoDB" id="7989680at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33332">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="388"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5100539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="415" mass="48813" checksum="54877EED182C6355" modified="2022-05-25" version="1">MVHGKSFITWDGINLSTLTFTILEGLQQGTVTSPILFIIYTSSILNILGLNSGNNSHSGVYADDEVAYVADSKIPIIQDRLTKIVNEKYKTYKLWNLKMNPEKSVTILFRKTVNEITPPTVRLIKTFQITVTDKDTGEEFPIPNQKVKYLGINFDYLLRMNKHHTIQLNKAKKAFRANSRIFCDRNIDSKAKLICYQLLVRPIMSYAAPIWWNIGPSVMEKYRKFERSCLKKCLGRYRSPESNYLKYLSNKEIYNLANIPRFDNFCLTLTRNYFSTINEIDNNIIKNLKIENIELIKRMTKSNYSPPEIFTNLDRQGCMQDGNNVPIIYHIRRHCAKKAIFTELDNIPAESIVYSKALPARDKDSLERLSEKYWWLQGEAKHLDEIRRRARHKQQQIQRRQRDRCQARRRHRHRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HJN7</accession>
    <name>A0A8J2HJN7_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Similar to Dnajc7: DnaJ homolog subfamily C member 7 (Mus musculus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HICCMSTLAB_LOCUS11710</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5103839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HJN7"/>
    <dbReference type="OrthoDB" id="765884at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013105">
        <property type="entry name" value="TPR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45188:SF2">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45188">
        <property type="entry name" value="DNAJ PROTEIN P58IPK HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00515">
        <property type="entry name" value="TPR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13432">
        <property type="entry name" value="TPR_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07719">
        <property type="entry name" value="TPR_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="33"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="183"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="229"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="301"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="4">
        <location>
            <begin position="354"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAG5103839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="469" mass="54006" checksum="0BE323CE11D350A1" modified="2022-05-25" version="1">MADEIMDLDMDVNDEIVISDSEDSPVNTAEELAEIQMEEAKKYYTDKQYKSALASYSKAIEYCPNVAKYYGNRAACYMMLELYREALVDSRKSIEIDPTFVKGYTRTIRCCLKMGEIVEAETLLNKLNTIDPTAAKSTITESQEISYVQRFLKEANVALESKDYRKEAQEIANDILHLDRSNVDATYVRGVCLYYQDNVDRAFAHFQEVLRLAPDYVKALEMYKKAKLLKQKKEDGNVAFKAGRYQEAYNLYSEALTIDPQNKMNNTKLHYNRALTASKLGRLNEAITECTEALKLDDNYLKALLKRGACYMELQEYEDAVRDYEKACKINKSRDNRRLLLEAKEALKRSKKKDYYKILGVERTASTEDIKKAYRKRALVHHPDRHSNASEPEKKEQEKKFKEIGEAYTILSDPKKRSRYDRGGDIDEMETGFDLSNFGTDSAFAAFFSKPDTGGFHFQFAGYNDNSPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HJV6</accession>
    <name>A0A8J2HJV6_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">Queuosine 5'-phosphate N-glycosylase/hydrolase</fullName>
            <ecNumber evidence="6">3.2.2.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4 6">Queuosine-nucleotide N-glycosylase/hydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HICCMSTLAB_LOCUS9430</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the hydrolysis of queuosine 5'-phosphate, releasing the nucleobase queuine (q). Is required for salvage of queuine from exogenous queuosine (Q) that is imported and then converted to queuosine 5'-phosphate intracellularly.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 6">
            <text>queuosine 5'-phosphate + H2O = queuine + D-ribose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:75387"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17433"/>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
            <dbReference type="ChEBI" id="CHEBI:194371"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="5 6">
            <dbReference type="Rhea" id="RHEA:75388"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the QNG1 protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.-" evidence="6"/>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5100192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HJV6"/>
    <dbReference type="OrthoDB" id="416777at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019438">
        <property type="entry name" value="Q_salvage"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21314:SF0">
        <property type="entry name" value="QUEUOSINE 5'-PHOSPHATE N-GLYCOSYLASE_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21314">
        <property type="entry name" value="QUEUOSINE 5'-PHOSPHATE N-GLYCOSYLASE_HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10343">
        <property type="entry name" value="Q_salvage"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00035119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00035306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAG5100192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="152" mass="17682" checksum="64E817F90ECB20F1" modified="2022-05-25" version="1">MSLSASVMKLIFMDIERAQILVGDIWACYKGKDLGEFNDIDIITMFADYRIPQVLLHFGAMRYSNPLLSTLQTGTELTPGCIEEIEIRGCSIEVIERVVDRVRNLIKQYPNLNINPFSCNSIVVDHFLWDYRRKNAEKLESIPFHRTRSIYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HK42</accession>
    <name>A0A8J2HK42_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 17">Exonuclease 1</fullName>
            <ecNumber evidence="17">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">HICCMSTLAB_LOCUS10265</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="17">5'-&gt;3' double-stranded DNA exonuclease which may also possess a cryptic 3'-&gt;5' double-stranded DNA exonuclease activity. Functions in DNA mismatch repair.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="17">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="17">Binds 2 magnesium ions per subunit. They probably participate in the reaction catalyzed by the enzyme. May bind an additional third magnesium ion after substrate binding.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 17">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 17">Belongs to the XPG/RAD2 endonuclease family. EXO1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="17"/>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5101192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HK42"/>
    <dbReference type="OrthoDB" id="26491at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035312">
        <property type="term" value="F:5'-3' DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017108">
        <property type="term" value="F:5'-flap endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09908">
        <property type="entry name" value="H3TH_EXO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09857">
        <property type="entry name" value="PIN_EXO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.20:FF:000011">
        <property type="entry name" value="exonuclease 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1010:FF:000002">
        <property type="entry name" value="Exonuclease 1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036279">
        <property type="entry name" value="5-3_exonuclease_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037315">
        <property type="entry name" value="EXO1_H3TH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008918">
        <property type="entry name" value="HhH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044752">
        <property type="entry name" value="PIN-like_EXO1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006086">
        <property type="entry name" value="XPG-I_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006084">
        <property type="entry name" value="XPG/Rad2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019974">
        <property type="entry name" value="XPG_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006085">
        <property type="entry name" value="XPG_DNA_repair_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081:SF8">
        <property type="entry name" value="EXONUCLEASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081">
        <property type="entry name" value="FLAP ENDONUCLEASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00867">
        <property type="entry name" value="XPG_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00752">
        <property type="entry name" value="XPG_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00853">
        <property type="entry name" value="XPGRADSUPER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00279">
        <property type="entry name" value="HhH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00484">
        <property type="entry name" value="XPGI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00485">
        <property type="entry name" value="XPGN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47807">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00841">
        <property type="entry name" value="XPG_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00842">
        <property type="entry name" value="XPG_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 17" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9 17" id="KW-0228">DNA excision</keyword>
    <keyword evidence="15 17" id="KW-0234">DNA repair</keyword>
    <keyword evidence="14 17" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="13 17" id="KW-0267">Excision nuclease</keyword>
    <keyword evidence="11 17 21" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="10 17" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12 17" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 17" id="KW-0540">Nuclease</keyword>
    <keyword evidence="16 17" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="XPG N-terminal" evidence="20">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="XPG-I" evidence="19">
        <location>
            <begin position="138"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="464"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="616"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="690"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="18">
        <location>
            <begin position="691"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="701"/>
            <end position="710"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU910737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="SMART" id="SM00484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="SMART" id="SM00485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="CAG5101192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="733" mass="82375" checksum="F3611D597596D2C3" modified="2022-05-25" version="1">MGITGLLPFLDKSSKRGNISQFSGGTVAIDTYCWLHKGVFTCAEKLALGEPTDGYVQYCLKYVQMLLANRIKPILVFDGCYLPAKAETEIKRRESRETNKRRAAELMKMGRNAEGKAILRRSVDVTHEMALQVIKKCQELNVDCIVAPYEADAQLAYLNTSGIADVVITEDSDLTLFGCTKIFFKMDINGNGVLVEQDRLHLAMNLSPSQFDLDKFRHMCILSGCDYLPSLPGIGLNKAFKFILKNTDPDIHKALVRLSSYLNMKSLCVTPEYRDGFIRALVTFKHQLVFCPIQRKQVRLIPPPPEVTPEQLHHAGDEKPADLAFQLALGNYDPTSMKKLYDYNPDKALSRPRNSWHKGSGIPSSSIWSKDFKISGLKKTPVKNNKSNNTKWPNTAGKVITSNTDALKFKPSPLKRSFEDMETDLSESDIIKMYGSNKIQKNEAIIETKIKKEEEEEEVMEEIKELKTPPPASPQNKPNPFLKKSPQTSPCLVRGSRRRKVRTFVAVAPTVVNETSPVVSKYFFDESKMTNEEVKPATNLINPGSHIIPETQDEDLPEDLPLSQPDSYKENKIVNNEKFRERQKLSRLDSGIDMKNNNDYYVNNDVKLCSEVNQVSEVTSPAEEDTGNYSFSAEDREKNSEGDPATDDGIDCSANTSRVNNLRSSLFKWSNPKINLSKVNSFDSSPITVKNSKKLQRTKSAKISSAKKSPPAQPTQQNLLNSYGFKKKKVLKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HKA4</accession>
    <name>A0A8J2HKA4_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS9511</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5100353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HKA4"/>
    <dbReference type="OrthoDB" id="7699118at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5100353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="168" mass="19703" checksum="164E498C68558C72" modified="2022-05-25" version="1" fragment="single">TLITFLIDHWATQEMAPFIGDIIINSTNNPNEPYEKRFKNYDTSNLLPCKAELKQQILRTQYITSIWQNAHLRFPSTLAPTRNGWDLQDGKFEFYWFEGDCMPLSIMDASKAENRNEKQNTMISEDIDEITAYSRAGHCYGQRNYPLLLTNNFRTVKIHAKKNYIQDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HKG3</accession>
    <name>A0A8J2HKG3_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS9917</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5100844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HKG3"/>
    <dbReference type="OrthoDB" id="8194903at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579">
        <property type="entry name" value="F5/8 TYPE C DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579:SF1">
        <property type="entry name" value="F5_8 TYPE C DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5100844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="424" mass="49074" checksum="0CF114700F4325A9" modified="2022-05-25" version="1">MKRGPYKLYLQGDSDGVMPDSTFYRKLRRLKNDNLYDTNKLLNKEDMKEQNITSAIPDAETTDSQNSLIMESINNEDGLLSDYQENNGVENVYQNSWLYDEYDEQTLEQEIWFDAEDSPPVGDLNSIYNYDAHQDEHNESDNGDDYRKPLCNCTTVTRGEALLMTLLLGAEHSLTWKTITAILSLINTLLGEEVVPASKFKLFKLLNLNENILTYHLFCKECLHYFGVQNKLDKKNLICEICKNNENSSDISYFLTLDASLQLKKILEDVEIAGSLIVRYVALYQEYFGKGAMIYNIHLLLHLKRSVLNLGPLRYHNTFIFENENHFLLKLQKSPKNIDIQIARRYLFQKSLSSLQNKIELSDGFVKFCERNLTGQLKNAFKVDSCTLIGKGKNYKLNDTERKLLNLSDNYEVIEKFESGRNKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HKV9</accession>
    <name>A0A8J2HKV9_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Odorant receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HICCMSTLAB_LOCUS10622</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Cell membrane</location>
            <topology evidence="1 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the insect chemoreceptor superfamily. Heteromeric odorant receptor channel (TC 1.A.69) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5101720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HKV9"/>
    <dbReference type="OrthoDB" id="6604226at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005549">
        <property type="term" value="F:odorant binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004984">
        <property type="term" value="F:olfactory receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004117">
        <property type="entry name" value="7tm6_olfct_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21137">
        <property type="entry name" value="ODORANT RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21137:SF35">
        <property type="entry name" value="ODORANT RECEPTOR 19A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02949">
        <property type="entry name" value="7tm_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 10" id="KW-0552">Olfaction</keyword>
    <keyword evidence="8 10 11" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="9 10" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="49"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="73"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="140"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="182"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="304"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="336"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU351113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAG5101720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="433" mass="49856" checksum="19B345C60DA25D01" modified="2022-05-25" version="1">MIKIINNTSVESHRRFLDKSIAILRFSGVLSYDTSTTGHLRIFTIFMRVFSNIIVISYVLTMFADAVVNCNDLMIFASDGCFIAGWFVAYSKEAAFYRKRHRFFEFIDNTHRPVDVLRQSTDLGLLLDVKECMLYEAIDYYLVSLFVIVLGSAIIISSLILGKLPNRAIFPFDTTIPVYYRLAFFIQAYNTVYHLIVLVTIDFISWQLMRYTTLQLRVLSFNYINCKGDSLIPVAPDLTREYIGALKISSVFSIDDQHKEIRQFTAFEEREMTNISVNFTERFKTCVKHHLRLIRVVKDFNDTFSFSLMVQLGGSLLVICLNGYMVVTFPGDRDNFIRSTAYLLSGFTQLLYWCAFGNQLKFQADFLTKSQWMSGWENSYDRGIKNLVTTAMIKTMQPLEIRAGGLFVLTMETFLSILKSSYSVFVLLTTAND</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HL53</accession>
    <name>A0A8J2HL53_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNase H type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS9676</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5100603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HL53"/>
    <dbReference type="OrthoDB" id="7700353at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09276">
        <property type="entry name" value="Rnase_HI_RT_non_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002156">
        <property type="entry name" value="RNaseH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00075">
        <property type="entry name" value="RNase_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50879">
        <property type="entry name" value="RNASE_H_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase H type-1" evidence="1">
        <location>
            <begin position="85"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5100603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="353" mass="40295" checksum="BE00D07F5CE1D00D" modified="2022-05-25" version="1">MYQIPRRPQPHTGTKNTEIRSLVKNYTSNSELQNISLSHPKLPPFPPWTSTSDFIDLSIYDLFFGKANTPETVYRSLYQEKINHLNQFTKILTDGSIFNGSRGCAIIVNDDIYRFKLPNSFSIFSCKAFAILGSLNITAQLDLDNVAIFSDLKSVIEALKNFNSPDSIIQQCQSKIINLNLSKKVKVIWIPSHEGITGNELADREAKEATTSGIDLTHQLPTTTADFKKTTKKHIYDKWNTRWSNGLSHLHKSRKNIYEPRPHKQRRMNQCAIIRLRIGHTKFSNGHLLTKSTPKTCPACNEPASVSHAIESCSELNQLRLQYKIPNQLQNTLNDERHCLQLIKMLKSLELNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HL79</accession>
    <name>A0A8J2HL79_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HICCMSTLAB_LOCUS9721</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5100648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HL79"/>
    <dbReference type="OrthoDB" id="7696379at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="98"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="66"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="131"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="66"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="83"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="131"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="152"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="172"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="184"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="208"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG5100648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="260" mass="30749" checksum="63AF8DFF743B5171" modified="2022-05-25" version="1">MNKNESVNEFCERFDAIIREYETCGEGVELTKQEMRSAFYQAVTPGIPQLRDADLIKRTNSKEMTLEEIKSSREEEQQDDQNIKANRVNSGSRGREDRCHRCSGPGHWEQQCPWKEKGMWDCYECKKMTDHKASDHEKYPDRFRKRGGNTFRGKDFKKHDKTEYNKNQYRGRGLEKNEQKGVKSNKNNKSTKNTKSNYNNYKSANNNRDQKGKESLRREKVENVKKLKDSAIGREKESITSSFREEDLKKFRVKEARHRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HLA4</accession>
    <name>A0A8J2HLA4_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Riboflavin kinase</fullName>
            <ecNumber evidence="3">2.7.1.26</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">ATP:riboflavin 5'-phosphotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Flavokinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">HICCMSTLAB_LOCUS10518</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="15">Catalyzes the phosphorylation of riboflavin (vitamin B2) to form flavin-mononucleotide (FMN), hence rate-limiting enzyme in the synthesis of FAD. Essential for TNF-induced reactive oxygen species (ROS) production. Through its interaction with both TNFRSF1A and CYBA, physically and functionally couples TNFRSF1A to NADPH oxidase. TNF-activation of RFK may enhance the incorporation of FAD in NADPH oxidase, a critical step for the assembly and activation of NADPH oxidase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>riboflavin + ATP = FMN + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:14357"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57986"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.26"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:14358"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cofactor biosynthesis; FMN biosynthesis; FMN from riboflavin (ATP route): step 1/1.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.26" evidence="3"/>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5101616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HLA4"/>
    <dbReference type="OrthoDB" id="276388at2759"/>
    <dbReference type="UniPathway" id="UPA00276">
        <property type="reaction ID" value="UER00406"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008531">
        <property type="term" value="F:riboflavin kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009398">
        <property type="term" value="P:FMN biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.30:FF:000002">
        <property type="entry name" value="Riboflavin kinase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.30">
        <property type="entry name" value="Riboflavin kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023468">
        <property type="entry name" value="Riboflavin_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015865">
        <property type="entry name" value="Riboflavin_kinase_bac/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023465">
        <property type="entry name" value="Riboflavin_kinase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22749:SF6">
        <property type="entry name" value="RIBOFLAVIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22749">
        <property type="entry name" value="RIBOFLAVIN KINASE/FMN ADENYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01687">
        <property type="entry name" value="Flavokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00904">
        <property type="entry name" value="Flavokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82114">
        <property type="entry name" value="Riboflavin kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0288">FMN</keyword>
    <keyword evidence="10 18" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="11" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Riboflavin kinase" evidence="17">
        <location>
            <begin position="6"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00029789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00050912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00054097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00077632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM00904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="CAG5101616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="148" mass="16560" checksum="584E541B93A39C9C" modified="2022-05-25" version="1">MSNDSLLPYYAKGTIVKGFGRGSKALGIPTANFPEDVVAQLPEGFNTGIYYGWAALEGEIYKMVMSIGWNPFYQNEKKSMEVHILHKFSNDLHGRELKIVITGFIRPETSFDSVEALIAAINNDIKIADQRLEDPKMNELKSTLLTDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HLT8</accession>
    <name>A0A8J2HLT8_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS10024</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5100951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HLT8"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="141"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="155"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5100951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="193" mass="21456" checksum="872D7A9525AD4193" modified="2022-05-25" version="1">MRKLICDESKSTKNEITAGILKVQESVDALSQSVNERINIIEEGQHKLGKKVVTLEGNIKANTEKIKALEEHPPGDESILDEVEDRLARRNNVLLFNLPEPIQSDLEARSEADASLITKICNTLGIDSSSSSLTSQYRVELHTKEEDQPTSPRSGPERRSDDIRSYSTSTPAAQRVPGRSISVESRTEKPIYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HMA8</accession>
    <name>A0A8J2HMA8_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS10372</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5101299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HMA8"/>
    <dbReference type="OrthoDB" id="653904at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5101299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="146" mass="16197" checksum="30F1A7222FF1B46C" modified="2022-05-25" version="1">MPKHSVHLIYLVKSVPDVSNADDEVQSPPMTPAPTGINSINPPLNITRVHPEIRIPKELTITKKSTEVNNHSQDCLEAIKSNIKLEEAAPSPNRVPNFQIAIPSSFNDGKPNFYTEVNPLNLSTQQIKEENSSLINVNSIDEDYDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HMB2</accession>
    <name>A0A8J2HMB2_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Similar to Taf10: Transcription initiation factor TFIID subunit 10 (Mus musculus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HICCMSTLAB_LOCUS11825</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the TAF10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5104084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HMB2"/>
    <dbReference type="OrthoDB" id="154356at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990841">
        <property type="term" value="F:promoter-specific chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07982">
        <property type="entry name" value="HFD_TAF10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003923">
        <property type="entry name" value="TAF10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21242">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21242:SF0">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03540">
        <property type="entry name" value="TAF10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01443">
        <property type="entry name" value="TFIID30KDSUB"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAG5104084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="89" mass="10157" checksum="885316F912B3301C" modified="2022-05-25" version="1">MEQKNNEMEMINDEEIKTAGQPFVRLISLAAQKFISEIANDALQHCKTRGANQNTKSKGKDRRYTLTMEDLIPAVAEYGIVVKKPHYFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HNK3</accession>
    <name>A0A8J2HNK3_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Similar to feh-1: Protein Fe65 homolog (Caenorhabditis elegans)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HICCMSTLAB_LOCUS11687</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5103793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HNK3"/>
    <dbReference type="OrthoDB" id="5969782at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001540">
        <property type="term" value="F:amyloid-beta binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01272">
        <property type="entry name" value="PTB1_Fe65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01271">
        <property type="entry name" value="PTB2_Fe65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000034">
        <property type="entry name" value="amyloid beta A4 precursor protein-binding family B member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000317">
        <property type="entry name" value="Amyloid beta A4 protein-binding family B member"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039576">
        <property type="entry name" value="APBB1/2/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006020">
        <property type="entry name" value="PTB/PI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14058">
        <property type="entry name" value="AMYLOID BETA A4 PRECURSOR PROTEIN-BINDING FAMILY B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14058:SF8">
        <property type="entry name" value="PROTEIN FE65 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00640">
        <property type="entry name" value="PID"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00462">
        <property type="entry name" value="PTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01179">
        <property type="entry name" value="PID"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="WW" evidence="4">
        <location>
            <begin position="210"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="domain" description="PID" evidence="3">
        <location>
            <begin position="298"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="domain" description="PID" evidence="3">
        <location>
            <begin position="488"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="104"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="137"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="104"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="140"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="182"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="192"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS01179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAG5103793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="621" mass="68772" checksum="0A354EF2FB44ABE9" modified="2022-05-25" version="1">MQSKLIILNDKKNGLLSFENPNYHLESARFDDALNSNGTENSLFDEFYQDLVVSGARREEMVTGIVNGGGGGDGGGGGTRHARRTYATLDLESMGVDVTQGPLTQNSVTAETPDNTANHNLGYGSEGAEVAESTLVDDNLNGNPRSSSKALSNPSATLDAGDSDLVRNDLYAVPVKRRQPKDQNITNQLHNNFKEKPDESESPHSEDKDENLPAGWEKHEDKDGPYYWHIKSGTIQREPPEATLNCKNENRKSLVKDNDSINNFHSLGMIINTVTRSNTSSALDQELENKRKEELALKFAVRSLGWTEIAEEDLTPERSSKAVNKCIVDLSLGRNDLLDVVGRWGDGKDLFMDLDEGALKLIDPENLTVLNTQPIHTLRVWGVGRDHGRDFAYVARDRSTRKFMCHVFRCDIPARTIANTLRDICKKIMIERSLHQNLAKPVDINGRTSLATRPTNLPTEHRRFHRNNDQPLVAQSFPTPMEEPKKVLRAQYLGSMQVTAATGMEVLNDAIDHMVTNTPINQWRNVNVAVAPSMISILTPNDEKLITECRVRYLSFLGIGTNVKQCAFIMHTAQDLFIAHIFNCEPSSVKSSKPIGSPGTVATACRARGDSTQASQVTVDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HNW0</accession>
    <name>A0A8J2HNW0_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Similar to Amot: Angiomotin (Mus musculus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HICCMSTLAB_LOCUS12788</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell junction</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the angiomotin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5107527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HNW0"/>
    <dbReference type="OrthoDB" id="5974715at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005923">
        <property type="term" value="C:bicellular tight junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030334">
        <property type="term" value="P:regulation of cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009114">
        <property type="entry name" value="Angiomotin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051747">
        <property type="entry name" value="Angiomotin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024646">
        <property type="entry name" value="Angiomotin_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14826">
        <property type="entry name" value="ANGIOMOTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14826:SF14">
        <property type="entry name" value="ANGIOMOTIN_C DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12240">
        <property type="entry name" value="Angiomotin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01807">
        <property type="entry name" value="ANGIOMOTIN"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0965">Cell junction</keyword>
    <keyword evidence="5 6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Angiomotin C-terminal" evidence="8">
        <location>
            <begin position="543"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="203"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="338"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="576"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="714"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="817"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="908"/>
            <end position="974"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1029"/>
            <end position="1126"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="411"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="598"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="63"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="87"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="203"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="217"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="587"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="717"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="821"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="951"/>
            <end position="962"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1052"/>
            <end position="1066"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1069"/>
            <end position="1089"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1096"/>
            <end position="1107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAG5107527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="1126" mass="123088" checksum="59CFDDE3D6B395F8" modified="2022-05-25" version="1">MSSIQQTGRFLPFTNNSSNIQRKQLSTQGGLPQSLSGSDTDVSTSNENLSNEERYVIRHTARQEPQGQENQQQQSPSRSSSHKENIPNIQGNLINRNSLKDSLNGSNRNSLKESLNGSNRNSLKDSINGSNRNSLKDNLSNRTSVGSNRSSLDISTSSYNTLIIHNANDENGWSPSGRLSSIVREHGGDVGYLYNEGGGGGGGGGGGGGGGGGGKGHSNSPTMQSLTSLPHDERFYEQPNNGGCQEINDIPDDYLNQSQVLKHLAKEVKPYSKLQSGGNNLEIRMREVDRAKQINNEFNDRSQSSYISILMPAKSKHRLLGPTEKLTLSRSQPDLSRIDKLDFDGYDSPATSPRPQTKGREEVEIATGEIWPPSEMVQIIIQENSALKLELERCYSKVAKSQKLEQEISKVHRAHEELAASCERREKLERAARLRLQNDCRRLTELNRALRDQIDLLSSRSDNPPIVESMRKELTQRELLIGQLITQNKELAASKDRQEIELAAQRATLQEQRTHIDILDTALTNAQGNVVRLEEECRKKQIYVERVGQLQRALSSLQASSDRREETERHLRGQLERELREGGSGSNGHEQSSNGETITELKRRLRERDEKIMSLEGDVAKWEQRYLEESALRQAAIDAASLPKDAKIAALEKTSQDAEKMIAEARSEKMRHMDEVHAAQKKLADLESRMKDLESKLAERDAMIRVLQKHTYDKDSSSSSGMGSYPAVHSSHSSTSADHTGLTGTPELGRYCSNVTKAIDASALSHRSFTYVISEQCVGWDQWLWQYWNRALCCFPGFSNPGTASRKGKISKPLLAGVGHSTGSSSTASSKSRLLDDSGGEPTVAGVGVGVGSGVGGGGGAGEGVNGGGLIEFTSSTSARYNKQGNAVVAVSSRLSDGKPEDMMLLEKQGRSSQRQRMQEGEPRRAGSLPPSSLPRPPRALKSSGNSRYCRLSDTETRKKSDPGPSVIDTIKTTRDSGNCTLEYGRFDSGKGMRRKKSVADAFVPNTLKKPSSGEYERLGEVDRKKMILGGGGDVKHRETQGRSLIPPPSRRIGDYGRLSDGDAKATLRKQTGGSSVRGLSTGSMVSSKSGGRDSGGTASSDASTSSLPPTKARSIPRPNNYRIQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HPT0</accession>
    <name>A0A8J2HPT0_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Similar to ZNF358: Zinc finger protein 358 (Homo sapiens)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HICCMSTLAB_LOCUS12639</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5107218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HPT0"/>
    <dbReference type="OrthoDB" id="427030at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001955">
        <property type="entry name" value="Jim, isoform G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000683">
        <property type="entry name" value="Zinc finger protein 252"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000505">
        <property type="entry name" value="zinc finger protein 32 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050636">
        <property type="entry name" value="C2H2-ZF_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47772:SF15">
        <property type="entry name" value="REDUCED EXPRESSION 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47772">
        <property type="entry name" value="ZINC FINGER PROTEIN 200"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="90"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="240"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="268"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="296"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="324"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="352"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="200"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="373"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="432"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="203"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="387"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="433"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAG5107218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="462" mass="50364" checksum="1CE078B34B91CE9C" modified="2022-05-25" version="1">MEEEEDTRTSISSSEDEDEDDVFGRPSALHYLKQPGVMLTSLGQGDGGASLEAHQYASPGAPNMSSVLPDIVQQNGKSSKGGANSDLRLFKCLTCGKDFKQKSTLLQHERIHTDNVSPHLIFKNGMTPTLWPQDVPFPPEEGKEEVASTFGDTDTQSGAFSPSPDGNSIQYPAYFKDPKGGNHAVFGAGGPGSFGALQYIKQQGGGGGGGGGGNSGPNGSKSCLPDVIQHGRSAGMPLYVRCPICQKEFKQKSTLLQHGCIHIESRPYPCPECGKRFRQQSHLTQHLRIHTNEKPYGCVYCGRNFRQRTILNQHLRIHTGEKPYKCQQCGKDFRQKAILDQHTRTHQGDRPFCCPMPNCRRRFATEPEVKKHIDNHMNPHASKVRRNSSSDGKPSGTPTALGPVPVPRGLTPTVVKPELYFPQCYAPAFNHQPPVSSSQFPGQTNGVAVTGEFKPPSALPPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HQS0</accession>
    <name>A0A8J2HQS0_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Similar to ube2i: SUMO-conjugating enzyme UBC9 (Xenopus tropicalis)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HICCMSTLAB_LOCUS13839</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein sumoylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5109203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HQS0"/>
    <dbReference type="OrthoDB" id="6600758at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd23798">
        <property type="entry name" value="UBCc_UBE2I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000013">
        <property type="entry name" value="SUMO-conjugating enzyme UBC9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 9" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="10">
        <location>
            <begin position="4"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="8">
        <location>
            <position position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAG5109203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="159" mass="18095" checksum="FE4ADAD3B405E19C" modified="2022-05-25" version="1">MSGIASARLAEERKAWRKDHPFGFVARPTKNADGSLNLMSWECAIPGKKSTPWEGGLYKLRMIFKDDYPSSPPKCKFEPPLFHPNVYPSGTVCLSLLDEEKDWRPAITIKQILLGIQDLLNEPNVKDPAQAEAYTIYCQNRLEYEKRVRAQARAMAPQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HR27</accession>
    <name>A0A8J2HR27_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Small ribosomal subunit protein mS25</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">28S ribosomal protein S25, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HICCMSTLAB_LOCUS13320</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrion-specific ribosomal protein mS25 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5108604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HR27"/>
    <dbReference type="OrthoDB" id="5919182at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007741">
        <property type="entry name" value="Ribosomal_mL43/mS25/NADH_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040049">
        <property type="entry name" value="Ribosomal_mS25/mL61"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13274">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOMAL PROTEIN S25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13274:SF2">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN MS25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05047">
        <property type="entry name" value="L51_S25_CI-B8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00916">
        <property type="entry name" value="L51_S25_CI-B8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal protein/NADH dehydrogenase" evidence="8">
        <location>
            <begin position="37"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAG5108604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="177" mass="20214" checksum="EC8BEA9CE64F8CAC" modified="2022-05-25" version="1">MPFMIGKSPIRRTMKYLNAGKLALKNGIQVFSINYNTHGEHHQGAKDFIFWYVPQVQYRNPEVQVISIKNLTPSPFITCYYANGKKMLIDIESRTKEEIMEHLIKVVGKTQDVLEKEAAAAEKKINPANFGNGCPRHCICEVPGQLPCPSVVPLPFHMRGKYKYNPDLFAEVMEKMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HRB1</accession>
    <name>A0A8J2HRB1_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Similar to Rem1: GTP-binding protein REM 1 (Mus musculus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HICCMSTLAB_LOCUS13171</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. RGK family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5108305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HRB1"/>
    <dbReference type="OrthoDB" id="5239715at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005246">
        <property type="term" value="F:calcium channel regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000664">
        <property type="entry name" value="Uncharacterized protein, isoform B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051641">
        <property type="entry name" value="RGK_GTP-binding_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45775">
        <property type="entry name" value="RAD, GEM/KIR FAMILY MEMBER 2, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45775:SF6">
        <property type="entry name" value="RAD, GEM_KIR FAMILY MEMBER 2, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="226"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="406"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="14"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="33"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="55"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="79"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="144"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="166"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="197"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="226"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="406"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="675"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG5108305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="675" mass="74629" checksum="370723FC31828E28" modified="2022-05-25" version="1" fragment="single">MAMNSPGPFTNLKSPRSPRQLPQLPPSILSSSGQRSPSQQLQNLGCKSPSTPRVFEFPPEYYPETPNANFDFEDFGKMSSSRSSLLPESDSCSIVNRSSSFYSQNSSGMKSPRASESSKSPVFSFCNPKKNFGKTLSYPPKSPASPSSLGPIIRSRSPSCGSSQSFTQKSPNSANYSRRNSCLNLRPLNSPKTIVTSSSRSPSPRAADADEFEECSTTKDLGDKFYKGAESKTVKRQDRDSPQNARKRLGSVQLNKSYGCLNEVTEKISMRSSGKNISRRSTSDLTDAAAVDENETEITILSSPRRKGSMKGGLAYLASRRGSRDSQISNISNISNEDIGPLNFSAHPRGRQRRTSNFLELPVPDHIRPRVHSLPEKPYNPRAGDDLYRLRAFSITHKGVVNRGDSIISRRSRSNTSVNSSRNSNVSGERSPFEGSCCSGQGAVCDSTESEAEEVSKYRVVLLGDSGVGKTALVSQFMTSEYMNTYDASLDDEFGEKTVSILLDGEESDMIFIDHPHVEMSLENSLTTYEPHACVVVYSVVSRPSFQVAEDMLNYLWREHYTQDRSVIVVGNKSDLARSRCIDANEGKQLATSRECKFIETSSGIQHNVDELLVGILKQIRLRETRDKKLRRRGSKSKMLTKLHGSKTALSLNLAREILNKMCMNDSKSKSCENL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HRF1</accession>
    <name>A0A8J2HRF1_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similar to ringer: Tubulin polymerization-promoting protein homolog (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS11835</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TPPP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5104104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HRF1"/>
    <dbReference type="OrthoDB" id="548799at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015631">
        <property type="term" value="F:tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046785">
        <property type="term" value="P:microtubule polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008907">
        <property type="entry name" value="TPP/p25"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05517">
        <property type="entry name" value="p25-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5104104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="118" mass="13594" checksum="6D296CCDECBE27C8" modified="2022-05-25" version="1">MFVSEAAKKRDPRIVPLRDMFEAYCQLDTLADVIEVDLLSFSQLNRWLVSAKVIDESRVTSTDAFLCFFQFKKRAISYDEFLIYLEDLADTKELSLSRVKYKLQTCGKPPEPTHSSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HRM8</accession>
    <name>A0A8J2HRM8_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS11985</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5104404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HRM8"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5104404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="68" mass="7501" checksum="EFD0A4997874A6C3" modified="2022-05-25" version="1">MPISLTRCPTGLLYIVSNFFASNLISKILFINAKNGARGNAATNIVINPYCKTENIQGTNFWVPIQQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HRQ1</accession>
    <name>A0A8J2HRQ1_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">DNA-directed RNA polymerase subunit beta</fullName>
            <ecNumber evidence="14">2.7.7.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">HICCMSTLAB_LOCUS13199</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="14">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="24">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the RNA polymerase III (Pol III) complex consisting of 17 subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the RNA polymerase beta chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="14"/>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5108362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HRQ1"/>
    <dbReference type="OrthoDB" id="10248617at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032549">
        <property type="term" value="F:ribonucleoside binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006383">
        <property type="term" value="P:transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00653">
        <property type="entry name" value="RNA_pol_B_RPB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.270.10:FF:000006">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.270.10:FF:000011">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1070.20:FF:000002">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1100.10:FF:000014">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1100.10:FF:000021">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1110.10:FF:000006">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1800.10:FF:000003">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1070.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1100.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.270.10">
        <property type="entry name" value="DNA-directed RNA polymerase, subunit 2, domain 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1800.10">
        <property type="entry name" value="RNA polymerase alpha subunit dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1110.10">
        <property type="entry name" value="RNA polymerase Rpb2, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015712">
        <property type="entry name" value="DNA-dir_RNA_pol_su2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007120">
        <property type="entry name" value="DNA-dir_RNAP_su2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037033">
        <property type="entry name" value="DNA-dir_RNAP_su2_hyb_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007121">
        <property type="entry name" value="RNA_pol_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007644">
        <property type="entry name" value="RNA_pol_bsu_protrusion"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007642">
        <property type="entry name" value="RNA_pol_Rpb2_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037034">
        <property type="entry name" value="RNA_pol_Rpb2_2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007645">
        <property type="entry name" value="RNA_pol_Rpb2_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007646">
        <property type="entry name" value="RNA_pol_Rpb2_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007647">
        <property type="entry name" value="RNA_pol_Rpb2_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007641">
        <property type="entry name" value="RNA_pol_Rpb2_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014724">
        <property type="entry name" value="RNA_pol_RPB2_OB-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20856">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE I SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04563">
        <property type="entry name" value="RNA_pol_Rpb2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04561">
        <property type="entry name" value="RNA_pol_Rpb2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04565">
        <property type="entry name" value="RNA_pol_Rpb2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04566">
        <property type="entry name" value="RNA_pol_Rpb2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04567">
        <property type="entry name" value="RNA_pol_Rpb2_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00562">
        <property type="entry name" value="RNA_pol_Rpb2_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04560">
        <property type="entry name" value="RNA_pol_Rpb2_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64484">
        <property type="entry name" value="beta and beta-prime subunits of DNA dependent RNA-polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01166">
        <property type="entry name" value="RNA_POL_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 14 22" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 14" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 14" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RNA polymerase beta subunit protrusion" evidence="18">
        <location>
            <begin position="40"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="17">
        <location>
            <begin position="186"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="19">
        <location>
            <begin position="438"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="20">
        <location>
            <begin position="539"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="21">
        <location>
            <begin position="621"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed RNA polymerase subunit 2 hybrid-binding" evidence="15">
        <location>
            <begin position="668"/>
            <end position="1042"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="16">
        <location>
            <begin position="1044"/>
            <end position="1129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU363031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF04560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF04561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF04563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF04565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF04566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF04567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="CAG5108362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="1134" mass="127854" checksum="1A1F854163FA074B" modified="2022-05-25" version="1">MGEMKMGNSEHIKEEDKYNRVARHIENKWKLVPAFLRGKGLVKQHLDSFDYFINVEIKKIVAANNLILSDSTDSFFLRYLDVRVGNPEELEFNVSTRVTPHECRLRDLTYSAGIYVDVEYIAKTRVIKKNICIGKMPIMLKSSNCVLRDATHFQLSKLNECPHDPGGYFIVNGQEKVILIQEQMIKNRIIIEKDNKGCIMASCNSSTDEKKTKTNIVGKNGKYYLRHNIFQDDIPIVIVFKAMGIVSDQEIIQLIGTDEESMEKFASSIEECRSLGIFSQNQALKFLAAKRKHRRFASTSKMSLTDEISDVLAQNVISHVPLVDFNFKSKATYLAVMIKRVIRAQSDSSLIDDRDYYGNKRLELAGSLLALMFEDLFKRYNTTLKQTTDKNIAKIKAAPYDITKHMNADSITNGLVFAISSGNWNIKRFRMDRKGVTQILSRLSYISALGMMTRVNSQFEKTRKVSGPRSLQPSQWGMMCPSDTPEGESCGLVKNLALMTHITTEIEEKPIARLVYNLGVESINILSGEEIQSKEVYMVFLNGNILGVIKNYNRLVNVFRMLRRQGLIDPFISIYLQHSHKCVQISSDGGRLCRPYIICKKGESLLTSEDITKLEQGIKTFDDYVHEGLVEYLDVNEENDCHIAFNEEHITYKTTHLEIEPFTLLGVCAGLVPYPHHNQSPRNTYQCAMGKQAMGTLGYNQRNRIETLQYNLVYPQKPMVSTRTIELINFDKLPAGQNAIVAVMSYSGYDIEDALILNKASIDRGYGRCIVYKNMKTTLKKYGSKTTPLQDGINGPKMCDGKPVKYHNVIDQDGIVAPGVLINHKQIVINKFVPANVNTTPGNPNSNDHKEQRETPVVYKGTIPSYAEKVMIGTNNSGECLIKVLLRQTRRPEIGDKFSSRHGQKGVTGLIVEQEDMPFNDQGICPDMIMNPHGFPSRMTVGKLIELLAGKAGVLNGEPHYGTAFGGSKISDVCEELVKKGFNYLGKDMFYSGITGEPLQAYIYSGPVYYQKLKHMVQDKMHARARGPCTTLTRQPTEGRAKDGGLRLGEMERDCLIGYGASMMLLERLMISSDAFKLDVCNQCGMMGYSGWCHNCKKSGCLSTITMPYACKLLFQELQSMNIVPKLTLKNYCD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HTR3</accession>
    <name>A0A8J2HTR3_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Similar to tea3: Tip elongation aberrant protein 3 (Schizosaccharomyces pombe (Strain 972 / ATCC 24843))</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HICCMSTLAB_LOCUS13345</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5108654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HTR3"/>
    <dbReference type="OrthoDB" id="432528at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006652">
        <property type="entry name" value="Kelch_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051568">
        <property type="entry name" value="LZTR1/Attractin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46376">
        <property type="entry name" value="LEUCINE-ZIPPER-LIKE TRANSCRIPTIONAL REGULATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46376:SF1">
        <property type="entry name" value="LEUCINE-ZIPPER-LIKE TRANSCRIPTIONAL REGULATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01344">
        <property type="entry name" value="Kelch_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24681">
        <property type="entry name" value="Kelch_KLHDC2_KLHL20_DRC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="678"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="779"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG5108654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="850" mass="93998" checksum="7C38E02B390BFDFF" modified="2022-05-25" version="1">MWSSVTSAGTENGPAPPSRSKHSATLLGGHVYLLGGRNGNLPLKDLWRYSLDSHIQAPILGSGLNLYVLNDQMRTAVEYPRANTSHSDSRYHGWLIDICIIQAINTLNRQSSCFGKRILKYISSQLNTDEELIKRPLSDILEAYEEFGILKRDHKGELKLNDTAQYPSVAGLRLPRRPQGCKCPDCVGKCGFCPTRSGKIAKRKPAESRWEELHPSGERPPALQEHSAVAYKDCLYVFGGELGFSAGTETPLWVYTVKTNSWRKIRAQRGCAVPRGRRGHTALVHRGQMLIYGGYQDLRGSSPELWAFHFETESWHLLSSSECGPAPRHKHSAVLHCEAMFIYGGMTDLQERNDCWKWDVKSATWSLLKSKPGPGALHGHAACRLPSCMLIFGGESNGSATNDLWRFHFATETWERLTVPGPKPQPRAESVALAVSELVIKGSGVQDNRTRLRSNKTRFSLSSSGGNRVSPCEAPTRPSFLKEISKLSQINLSRLSHPNKCSYSVLSGQEDTEECPQDVNSYYPFQQVDSELVEPSSGMVKSRSANALARRRQRTLAEANNRCSFESSSYEAKSARMTREPISVPNFRALTLPTPVLTPVEAARLVFVDPDEDSDDDRKGLATTRLIDVAEEKADFETLHQACQPTRGESYSSHLYEAVQSPKTPCATKIPTSASVRFADLEEGEESTSDYASIEARSPGDPLADDDWPDRKKSKQRAPTIREGQFGFCNPNYLGLETNDDKFAKLLNSPPDSVLEDASGRSASQTFAELLELQEVKPRAPPKSLALGSPSRRAVSASRAERQREKLAASEAVTPAPLYVFLVGGKEKGLAGVFARPVSLWKLQLAPHIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HUM0</accession>
    <name>A0A8J2HUM0_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similar to Sperm acrosomal protein FSA-ACR.1 (Vulpes vulpes)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS14046</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001501">
        <property type="protein sequence ID" value="CAG5109685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HUM0"/>
    <dbReference type="OrthoDB" id="10575791at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5109685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="133" mass="14798" checksum="20F2937179F9FE21" modified="2022-05-25" version="1" fragment="single">MRSRYLLEGDSDEEATRESPEGSNDEEASRESPEGEEDTRDPPDGEEDTRDPPDGEEDTRDPPDGEEDTRDPPDEGEEDTRDPPEGEEDTRDPPEGEEDTRDPPEGEEDTRDPPEGEEDTRDPPDGEGEGDNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MAR8</accession>
    <name>A0A8J2MAR8_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Similar to ZBED9: SCAN domain-containing protein 3 (Homo sapiens)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS2969</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001117">
        <property type="protein sequence ID" value="CAG5079267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MAR8"/>
    <dbReference type="OrthoDB" id="7674489at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37162:SF1">
        <property type="entry name" value="BED-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37162">
        <property type="entry name" value="HAT FAMILY DIMERISATION DOMAINCONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5079267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="610" mass="70629" checksum="2775EBBCDEC3BBE1" modified="2022-05-25" version="1">MEKWLQKTDLSCSESDSEVNLSKQRTKIVKKKRLTTKSKTNTPKFCEIWLNTPEFKDWIRKSSTKPNAAYCKICLTDIICYNKNCLSRHYKSSKHISNMETIENKASQQKIENLIQDLPLNKQIKRAEFILAATVAVKCLSFSLMDTLTPIISKISPDSKIAKQLSLKRTKTTAVIHSLSTVLLEELNEKLMKPGSFFSIIMDESTDVNNIKQCAFSVIYYDDKTAKIQTNFFDMVETDSATAEDLYSLLIKVITDKNIPLKNFVGFASDTANKMAGDNLSVFALLKKELPDIVTTKCSCHMIHLIASKACLKLSNSAEELLRNLAAYFHRSYKRIKGLEEFQEYFGVKIHKILSPSTTRWLSLKCCVDRVLEQYTPVHVYLQGELTDKSPPMLLSMVKTMDNRFTYVTLQFLSYALELFTDFNRLFQSEKPLLHKVKPEVEKLMKNICSNYIDITHIRRNDIMKLNHQDPHKYVPLNEVYVGTKANKSLEQLLTEKPSLELEVDEFRKKVLSFYIEAVTVLKQKFDFKDKIYEFLDLLDPKVARTFNIKSFDLVLKRFPVLNEYVTLQQLDNEWTEHALLNLEDNNIDINSTAEIYWQQIFKLTTQLVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MDD7</accession>
    <name>A0A8J2MDD7_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similar to fam92a: Protein FAM92A (Danio rerio)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS4125</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5084519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MDD7"/>
    <dbReference type="OrthoDB" id="60621at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035869">
        <property type="term" value="C:ciliary transition zone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009602">
        <property type="entry name" value="CBAR/FAM92"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21223">
        <property type="entry name" value="CBY1-INTERACTING BAR DOMAIN-CONTAINING PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21223:SF2">
        <property type="entry name" value="CBY1-INTERACTING BAR DOMAIN-CONTAINING PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06730">
        <property type="entry name" value="FAM92"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="282"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="298"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5084519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="311" mass="35602" checksum="D0465002ADB02AE7" modified="2022-05-25" version="1">MLKSKSQNNICEQEARFVQERITKVEKHFADLCTSFAAYARKAARLRDKNDELAKVIQNYATSETINQSLSRGLHNFGATLSVIGDYKDAEVQRIDSKIISTLSQYSMICRHAREDVKNTFSARDKELARRKHIDKLLLKKQGKSQTSQADLKSISNTVQVLKVVKGLEEQIDAFEKRKLQDLITLLLDFVMIELSFHTKAVELFTKAYQDIAEIDTFKDLEKFREILNASETFSRFDTVTRTSFRQSYSLTDLSNHQTPSPLQLKKMNRANESMDSLKAAVMKSSELSQVSEYDESSDTRDTESVEDIVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MG51</accession>
    <name>A0A8J2MG51_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS4972</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5088760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MG51"/>
    <dbReference type="OrthoDB" id="7677064at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="30"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="106"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="171"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="289"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="145"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="171"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="297"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="322"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="347"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="368"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="391"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5088760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="643" mass="72794" checksum="76AC6E782FC0DFAD" modified="2022-05-25" version="1">MPVEIRAVESHISRLVERQAKEDDPSSTKWIIVIIAILLLVVIIIITAAITIYKRSGKTRNVPLSQVPMCHPSCSGYNRFPQDVEDGWMSSKSDLPLAKCQRSAPVPVLPRLESEPERKPVKKPEKKPEKKKPEKKPEKKKRQSKEKSSEKVVQKVKKVEPVEKIVKTETKVEETEKTVKKEKKEKPKTDTESEETDVEPPKFINGPELREILDQHTSTCSCCACRPNPDGTADERTLCSDKFCNNRKAAQVMNRIKPFTNEHVRKSSWFKNRAKTICKFPSRKLSQDKEKLPLTCSPVNTATEGSTTESPPVTKRKSSSKSPPPLPPPPPPPPPPPPPPPPPPLPKEQKRESKAKEKSSRMEKSPRKSSTPKSSSKSPSRSSKKSLQPCVKNSCSAKNSSPRNSRPSKKDDIDIDQGYYELMNNFITGASEFPAPEKLARGVFTKDLVLYSSYYMSEMLQDFLLEYYQQASRAKNGMTRDMENAVERLTELFTRSTIPPEDDMKRVNNLLEKLLKCLPGNVKIKRKALPPLPSPNQVETHLGNEELSSLYLDLAGRIDRDLKSIRDLVDGVLLSGWEKARLSFNKVQDQLREDHLNPMLRSFSAEINKINDKEEIIKQHVTNGTWQAYKELNQRVNSALQSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MGF0</accession>
    <name>A0A8J2MGF0_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="3">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HICCMSTLAB_LOCUS5487</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase C19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="3"/>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5090098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MGF0"/>
    <dbReference type="OrthoDB" id="2248014at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02257">
        <property type="entry name" value="Peptidase_C19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF888">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="USP" evidence="8">
        <location>
            <begin position="1"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAG5090098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="390" mass="43488" checksum="2F22430BC2A03313" modified="2022-05-25" version="1" fragment="single">FYIIYFKGINGYSEDLYDDVAPIEVITSLGPLWNFDPGHQDAHELFHVILSALQNEIQTPNRKGCLSDALPGPEVAPDVKGSGDSIALRSVSCNDIARVQAHPNNIDRLDKNSNHSLALSTRSIPHFSLFNKPGVILARSSEILSRALGDSMDLQSPSKNWNSLCVIPQTSSCVLSHETHPFSGLLTSQLKCTNCNWKSAVRYDKLETISLPLPPASEALTWRRHTLSELFSRLVTSEVIHNVECNGCTSRCEAIKTLTLGKLPRCLCLHIPRTTWSNSGIPIKRDDPVIFPEIFVLDPFTFTESNKRNTQATLPMMLINNGSNQGKHRYKLQAVVEHRGPVDAGHFVCYRRGNRPGQWLYTSDTIVENMSLTDVLCASPYLLFYERIAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MHA2</accession>
    <name>A0A8J2MHA2_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Carboxypeptidase</fullName>
            <ecNumber evidence="10">3.4.16.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HICCMSTLAB_LOCUS3669</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="9">May be involved in vascular wall and kidney homeostasis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the peptidase S10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.16.-" evidence="10"/>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5082856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="443318at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004185">
        <property type="term" value="F:serine-type carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000075">
        <property type="entry name" value="Carboxypeptidase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001563">
        <property type="entry name" value="Peptidase_S10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018202">
        <property type="entry name" value="Ser_caboxypep_ser_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802:SF3">
        <property type="entry name" value="RETINOID-INDUCIBLE SERINE CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802">
        <property type="entry name" value="SERINE PROTEASE FAMILY S10 SERINE CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00450">
        <property type="entry name" value="Peptidase_S10"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00724">
        <property type="entry name" value="CRBOXYPTASEC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00131">
        <property type="entry name" value="CARBOXYPEPT_SER_SER"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10 11" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 10" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035339509" description="Carboxypeptidase" evidence="10">
        <location>
            <begin position="20"/>
            <end position="1285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00055847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAG5082856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="1285" mass="144955" checksum="87FA76969F6FF63C" modified="2022-05-25" version="1">MSRNLIVLLLSSCIIYAQLNNVEGKKGFGKGEQDWSYEEVRPGAHMFWWLYYANPPNKSANFNALSKPLVIWIHGGPGSSATGYGNFEEIGPYDLFGQYRNLTLVNDYNVLFIDNPVGSGFSYVDNESAYAQNNAQIARDLLECIKRFLQKIPAFKNIPTYIFGESYGAKMGAELATVWYKAQKCNDVQSKLKGVLLGSPWISPIDIVLSWPQFLLNTGIVDTVGARRIEASARKADESVKAENWKAATDAEVDTLNTIGQVSDNITQFNILIERSSHAGVQNFTTRFPKPPKTAEHWAELVRFVNTDVKRALGLTSNWVMDSEKVAEVLWSDIFKPGVSFVEELLNETNLKVYIYNGQLDLICALPGTLKWVENLKWKHDDAWKNSPRVPFSVDGILEGYVKAYKKFKILLLTIPTLQLQLSKISRHVNKVEGKKGFGPGDQEWGYVTVRPSAHIFWWLYYVNPPEKPTNFDPLSKPLMIWIHGGPGGSGAGYGNFMQFGPLDIFGHRRSYTWVNDYNVLFIDNPVGSGFSYVSDESAYAKNNTQIANDLFRCVNKFFEVIPTFKSVPTYIVGESYGSKMGVELASIWYKAQTSNSIQSNLKGVVLGVPWISPINSILSWGSFLLNTGIVDTAGYNEIEAETEIIRQAIEAGKWTEATDAKDVAFKIVDQVSAHISTSNIISERHSYGGIKNYTTIFPKPPKPPDNTTKLVSFMNNEVKQALGLISSWVLNPRIVVDNIRCDILKPVVYIVEELLNESDLKVSVYAGQFDLVVALPGTVKWVENLNWKHIAAWKKSPRLAFAVDNTIEGYVKSYNKLKMFWVLRSGHLCILFCSAQEIQTSSNLKSVPPTVVAHDRTHLDRAEAKPGFGPGDQDWGYVKVRSGAYMFWWLYYANPPTKPDNFNVYSRPLLIWLQGGPGASSAGFGNFGEIGPLDVNLQRRNHTWVNNYNILFIDSPVNAGFSFIDGNVTLPRDNKAIAYDLMRCMEGFLKAYTQFQTVPTYIIAESYGGKMATHFALLWDKVQHLTDGTEKFKSNLKGIGLGDPWISPLESILSYAPFLLNTGMINYKGYEKIQQAASLTKYAIDLGNWSNAIEQFKNTWITIINCTNNIDLYNLLEKKTPLFESHLAFSSLAQKTQQNARFDQKLNSLMNGSVRRTLGLIRPFKVRSYDIKHSLREDFLKPVTNIVERILNETNLKVFIYNGQLDVVIPTSSTLAWIEKLHWNGAENWKKSERKAITIDNYIEGYVQGFTKLKMFWINRAGHMVPEDNYQATHVMLHMLTNAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MHJ1</accession>
    <name>A0A8J2MHJ1_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ER-bound oxygenase mpaB/mpaB'/Rubber oxygenase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS3852</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5083482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MHJ1"/>
    <dbReference type="OrthoDB" id="6361347at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37159">
        <property type="entry name" value="GH11867P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37159:SF1">
        <property type="entry name" value="GH11867P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5083482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="335" mass="39406" checksum="EE783ED378713138" modified="2022-05-25" version="1">MLRKKREENLDQRLEDLLTDKSFIQSNYSNVSKENLPDWYDEKLFKQGQDYFSRNVLSMSAAALTGLITVLTIPTTLDILVFTKRSGCPRTAYRRYFETILHIYSLYTSDIDDPKSRFWKSLNTIRWKHSTNSKVAGENGVGFISQRDMALTQFGFIGYALLQPDKLGLTNDKAGREGLNHFWRVIGFMIDISNNVNICRESEEQTTEFCRKLLERVFTKWMTDTPKHFNKMIDAMLEGLWYVDVVLDADAMMYFWYDLNGLTYNKPLSWYSKFNYAYRKSIIFILGVPFIGQLVRVGFNNYLKLTYWFLERWPVIAWLKFGSEDSRINLYPIST</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MJ16</accession>
    <name>A0A8J2MJ16_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS2488</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001117">
        <property type="protein sequence ID" value="CAG5077527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MJ16"/>
    <dbReference type="OrthoDB" id="6130045at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5077527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="323" mass="34945" checksum="9503D847044D0025" modified="2022-05-25" version="1">MSEIEHLSVSPVPSQPGGTLVIQPSSYRILRSPSHESVTTDLSLFSVSSIASNAKSSNRLTTFKSYSDAHLSGRGSSPNPDARDKETELIRSCAALSSALGLQKSFSASDVSQLPSPEASCPQALRSAVSALALDSAHRDGFLLEQARLDHASRSCSTWVAVGDIASTSQLPSPHGGVSQQISSSLHPQPIPFTAADLVKSVNKKVRQNYIRRRLLTTYRALERLSQSEFNLDRLEAAASAAQTSGVTLIVPGTIPSITGSTIVNRKTNNDHPLTVNDVERERGKQLTKYERNMMIFNWLHNLDDDPDDSLPTESGVKVLKNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MJQ4</accession>
    <name>A0A8J2MJQ4_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS5639</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5090457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MJQ4"/>
    <dbReference type="OrthoDB" id="7697906at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5090457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="210" mass="24059" checksum="AFA2FD1D21EBC408" modified="2022-05-25" version="1" fragment="single">MSIRKPQHLTHSRAAVTGDDLKDWFDEQAKYLTEKKLMEIPCTRIFNCDETYVSLCPPSEKVLLAKGSRSAYKVVDSDKEGFTVLFMYSANGDLKKEDFPLVLKFALDATAQEKNAVISGFKAAGLYLFDPSAVDYDVFDKRKKSKITVTKENVQDEVTEDKEKHLLTFESNLSKDILEEFNTAWLNQTLPKDLEIRGLYKYWLDVSGKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MLY8</accession>
    <name>A0A8J2MLY8_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Similar to Rop: Protein ROP (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HICCMSTLAB_LOCUS8515</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the STXBP/unc-18/SEC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5097047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MLY8"/>
    <dbReference type="OrthoDB" id="2228at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051650">
        <property type="term" value="P:establishment of vesicle localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2060:FF:000001">
        <property type="entry name" value="syntaxin-binding protein 1 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.830.10:FF:000001">
        <property type="entry name" value="syntaxin-binding protein 1 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.830.10">
        <property type="entry name" value="Syntaxin Binding Protein 1, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043154">
        <property type="entry name" value="Sec-1-like_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043127">
        <property type="entry name" value="Sec-1-like_dom3a"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001619">
        <property type="entry name" value="Sec1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027482">
        <property type="entry name" value="Sec1-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036045">
        <property type="entry name" value="Sec1-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11679">
        <property type="entry name" value="VESICLE PROTEIN SORTING-ASSOCIATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00995">
        <property type="entry name" value="Sec1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005715">
        <property type="entry name" value="VPS45_Sec1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56815">
        <property type="entry name" value="Sec1/munc18-like (SM) proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG5097047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="586" mass="66541" checksum="912E695176C79B98" modified="2022-05-25" version="1">MNEVIKQKMNKKASAGGGGGAAAGAGANVEWRILVVDQLAMRMVSACCKMHDISAQGITLVEDINKKREPLPSMEAIYLITPCNGSVQKLIDDFSNPSRTIYKAAHVYFTEACPDDLFNNLRQTMVKKYIRTLKEINIAFIPYEEQVFSLDSRETFQCFYNPSFINARNANMERSAEQIATLCATLGEYPSVRYRSDFDRNVELAQMVQQKLDAYKADEPTMGEGPEKSRSQLLILDRGFDCVSPLLHELTLQAMAYDLLDIENDVYSYEASAGQGEKEVLLDENDELWVELRHQHIAVVSQNVTKNLKKFTESKRMPQGDKQSMRDLSQMIKKMPQYQKELSKYATHLHLAEDCMKRYQGNVDKLCKVEQDLAMGTDAEGERIKDQMRNITPVLLDQTVNNLDKLRIIALYVLSKNGINEENLNRLVHHAQVSTDDKQTIMNMASLGINVDGKGRKPYTVPRKERITEQTYQMSRWTPIVKDIMEDSIEDRLDTKHFPFLAGRAVSSGYHAPTSARYGHWHKDKGQQTIKNVPRLIVFIVGGVCFSEIRCAYEVTNAMKNWEVIIGSSHVITPKSFLSDLSKVHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MM04</accession>
    <name>A0A8J2MM04_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Endonuclease/exonuclease/phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS6572</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5093078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MM04"/>
    <dbReference type="OrthoDB" id="7698997at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="2">
        <location>
            <begin position="319"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="500"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5093078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="500" mass="57275" checksum="A0EA4894FD3620DB" modified="2022-05-25" version="1" fragment="single">QLNTISGTGDTHNLTGHPQMPPAVDLSTVIIPTTKRKRSGNTFNIPEDRSKISKMLNQQTNRHTIPLSNRFELLVDDSMELNEDNAQTSPTKNQQPTIKQTQNLAAKKEKKPPPIAIHGKVNDHSKITELIKCLVKEKFYIKYHQFHSEIFTTSMVDYTKLVEHLKATNVKFHTYSLKNEKKKTFVIKGLHEVTKPEHVQTELQEIGFDNTQVSLMKGTKYPIFMVAVTANTHLKHRIRHTKPNRSAALPPLRVRPAESNTNAWFNSSMQQNNLNARINQERLNININNNYHVSNEMSEFLELTNQRNSKNTIDNIKICSWNSNGLKNKLGEVIQFLNSYKIDIFLINETRLSDKDKLKIKNYNCIRKDKGHTAGGVAILIRKDLAYKELSIDNSITIECISIKLANEPTHYPTNNSTPTTIDIAIKKKVSQVSDMRVLHELNSDHTPVLLELGSQERNCAQKIAYDYKKADWTNFRKYLDQKTILTSTIKINDELDQTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MMV1</accession>
    <name>A0A8J2MMV1_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS7820</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5095662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MMV1"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035260595" description="Secreted protein" evidence="2">
        <location>
            <begin position="40"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5095662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="64" mass="6308" checksum="DCB1EDBAF3B4333E" modified="2022-05-25" version="1">MLSSSIAAASGCSSLSLSLSFSLPIKLLAGTALATLATATPTTGTPELAESSAKACSPEQPPHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MMY5</accession>
    <name>A0A8J2MMY5_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Ionotropic receptor 64a.2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">HICCMSTLAB_LOCUS9164</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5099647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MMY5"/>
    <dbReference type="OrthoDB" id="413361at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015276">
        <property type="term" value="F:ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050906">
        <property type="term" value="P:detection of stimulus involved in sensory perception"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052192">
        <property type="entry name" value="Insect_Ionotropic_Sensory_Rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001320">
        <property type="entry name" value="Iontro_rcpt_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057074">
        <property type="entry name" value="IR75A_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42643:SF33">
        <property type="entry name" value="GLUTAMATE RECEPTOR 2-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42643">
        <property type="entry name" value="IONOTROPIC RECEPTOR 20A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24576">
        <property type="entry name" value="IR75A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00060">
        <property type="entry name" value="Lig_chan"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 14" id="KW-0675">Receptor</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035317554" evidence="11">
        <location>
            <begin position="20"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="330"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="397"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="589"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="domain" description="Ionotropic receptor 75a N-terminal" evidence="13">
        <location>
            <begin position="25"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="Ionotropic glutamate receptor C-terminal" evidence="12">
        <location>
            <begin position="328"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="620"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="624"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="643"/>
            <end position="657"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF24576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CAG5099647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="657" mass="76219" checksum="7E26D41AF2BFB5AA" modified="2022-05-25" version="1">MDLRKGIFLLPLLIRLIKCDQFLENFTRDYYDSIHVYQLIVFGCWNLQEAHNFAKNVMRQEAKVSYNEISDNINLENILRLNSQTLGVILDHDCPSSHLILNQFSRQLAFNESYRWVLLTESLEFPTPSLRDLPLSVASEMTVAIRENNTYNLYDVYNPSYLHGGVINVTLMGYWTPEHKLVNNFKHQFKYHRRQNFNLLPLNVSIVLVNDPKPDLETYLTTPIDIHLDTMSRFTYQIVLQLKEYYNFSINMKRDISWGYKLNGTFDGIIGDMDKGIVDISSTPFQIKRDRLEVIDYTVHVMTIRTVFFFRHPKKNDMQNGFLKPFDTSLWYIVFGVAGVYWFILFVTTKAESHVENIKVPDNSLMSLPATETSLITMAALFQQGANDSPRLISGRIAFLSLFIWTLLLFQFYSATVVGFLLAPPAFWITTLKNLTDSSLSCGMEDMDYYRDFYATTYLETAIEMHEKKIKPTKKLPRGSYFPAVEGLLKVRDEPFAFHIEDTTAYRIIEDLFTEDQICELQEIPIRAAREVYVGVPRHSPFKEMITYGCRKSVEHGLANRLRKHWRYKKPPCPESHSSKPMPVMMKEFAPSLMFLSFGFGLSVFILFAECIYHAKFDRDSNEPDSQSITPVQSAGTAEQDIEEKFDHDETVPHFSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MPD5</accession>
    <name>A0A8J2MPD5_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similar to TBC1D13: TBC1 domain family member 13 (Homo sapiens)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS9379</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5100090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MPD5"/>
    <dbReference type="OrthoDB" id="10263206at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="1">
        <location>
            <begin position="1"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5100090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="131" mass="14835" checksum="6F72D5A7FCB3043F" modified="2022-05-25" version="1">MKRHNYRRLCPDISFFQQGTDYPCQAIVNANGPKRLHSRVQYTVLRSANVERKGLGVTKIAVSVRKAPEDYAPLAEGGEAHWEVLERILFLYAKLNPGQGYVQGMNEIVGPIYHAFACDPDPKWRGSLTIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MPM8</accession>
    <name>A0A8J2MPM8_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Similar to ptar1-b: Protein prenyltransferase alpha subunit repeat-containing protein 1-B (Xenopus laevis)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HICCMSTLAB_LOCUS9577</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein prenyltransferase subunit alpha family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5100484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MPM8"/>
    <dbReference type="OrthoDB" id="5358702at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008318">
        <property type="term" value="F:protein prenyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.120">
        <property type="entry name" value="Protein prenylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002088">
        <property type="entry name" value="Prenyl_trans_a"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11129">
        <property type="entry name" value="PROTEIN FARNESYLTRANSFERASE ALPHA SUBUNIT/RAB GERANYLGERANYL TRANSFERASE ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11129:SF3">
        <property type="entry name" value="PROTEIN PRENYLTRANSFERASE ALPHA SUBUNIT REPEAT-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01239">
        <property type="entry name" value="PPTA"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48439">
        <property type="entry name" value="Protein prenylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51147">
        <property type="entry name" value="PFTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0637">Prenyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAG5100484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="427" mass="50671" checksum="A8EFF0277DE2E99A" modified="2022-05-25" version="1">MQENTFPAAEKILSDIENVMKKDTNLQSFEIILEDDNENKSPVYHEENSLGLASWCVQPLYCYTYNRLIELRNNKLRREDPVMTSRWLLGAILLNPDVNTFWNMRRELVRNGRIDAIQELRFIKLVLYHKAKCFEAFSYRRWLIQFILIENLHVDNIESLLQEEINVAIISANRYANNYHAWSYRQHVVSMYEALISTNFHEFLISEWESSEKWCSLHVSDYSGLVYRQFLLKQLLIKSELIQSDDILSSEYVDERRKIIYEYINKYNNAQGCKDISYLDKESSCEFINTLHGNTNNQKSNVDYLQVLIALSYWIEDCILNEDLIKCYPGHEALWYHRRFLGHTLRCIKLSYSKYSCYKAESFESPYCIRLENSHQRSSDNDSRNLLEIAFKNHNIDVIEFSKQQGSYQSDIADKFIKFLGISHIEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MQ33</accession>
    <name>A0A8J2MQ33_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Similar to Rffl: E3 ubiquitin-protein ligase rififylin (Rattus norvegicus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HICCMSTLAB_LOCUS5037</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5088951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MQ33"/>
    <dbReference type="OrthoDB" id="3045089at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902042">
        <property type="term" value="P:negative regulation of extrinsic apoptotic signaling pathway via death domain receptors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070936">
        <property type="term" value="P:protein K48-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15750">
        <property type="entry name" value="FYVE_CARP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16500">
        <property type="entry name" value="RING-HC_CARP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000110">
        <property type="entry name" value="E3 ubiquitin-protein ligase RNF34 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.720.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.720.30">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051728">
        <property type="entry name" value="RING-FYVE_E3_ubiquitin-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055111">
        <property type="entry name" value="RNF34_RFFL_HeH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057299">
        <property type="entry name" value="RNF34_RFFL_SAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036361">
        <property type="entry name" value="SAP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14879">
        <property type="entry name" value="CASPASE REGULATOR, RING FINGER DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14879:SF15">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RIFIFYLIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22968">
        <property type="entry name" value="RNF34L-like_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23632">
        <property type="entry name" value="SAP_RNF34_RFFL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13920">
        <property type="entry name" value="zf-C3HC4_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF68906">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="320"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="124"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="226"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="124"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="231"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAG5088951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="367" mass="42268" checksum="ADD12FDE4C4610EC" modified="2022-05-25" version="1">MDNDITYKTILNSINNLNKIFDDMACEACSTKFTLFKRKKQCKDCLRFFCTDCVIRRGDRVLSCDNCSMLSRRPLIKSQVLTMKSKDLKQYLMAKKVSLRGCVEKEDLVNILMRYANGESQIDNELLTNNVSQPLRPQERQSTPPGSPPRRSRSPPINVRQTVESPQSEHEPFFPPRNHNVDIEEISSEEDISPSQGPEPLITEQEQEQDLEQVQPEVDPEIVIQEEENSPESSKSSDPSEFNELPSWTGNVKLSDIMERSDLEYLNVKQLKDLLRSNRVDFKGCLERSELLDRASRLWDAHKRSREDLSAEGLYDESLCKICWDSPIECVILECGHMACCINCGKQMNECPICRQYVVRVVRFFKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MS19</accession>
    <name>A0A8J2MS19_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNase H type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS11407</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5103233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MS19"/>
    <dbReference type="OrthoDB" id="7701509at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09276">
        <property type="entry name" value="Rnase_HI_RT_non_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002156">
        <property type="entry name" value="RNaseH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00075">
        <property type="entry name" value="RNase_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50879">
        <property type="entry name" value="RNASE_H_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase H type-1" evidence="2">
        <location>
            <begin position="608"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="203"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5103233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="901" mass="103287" checksum="612824DD378CC706" modified="2022-05-25" version="1">MDARNKDCRQAHSLSIVQWNARSIKPKLNELVHNSRNVDIFLISETWLKKKDIIYAKGFDVVRSDRARGNEGGVMIMVRSTLRYSVVRDLFDCNGAESTVDLTFVDYNSALLFEWKIGSDYWGSDHIPIFIRCDGRVQSGCERRKSNRLYNSAVDWSIYKSCISEKIPDLVELMSSENDIQTKYSSFTATLASSIQQACPSATRKLDGKPHQSKSKSKAPPSAWWNGECDRLVRLRKAALLKFKANRSCDNFIAYKKAQAEALVGLRRIKKESFKNFCASLSKNTNPKFLWNTIKGFQNRWNYRENANEYDKNKISAVKVMIEELCPPWVPNHRPCLNYDTADPFLDLAFIRDELQFALSELKLKNNRRTEPLRWNIVVKGSPISNSEVVRFLGMDLQAHLSWKHHIENVDKKCRNALKTINCLRRTWWGADPMLLIRVYRALIHSRLEYGGLVLFNLTKTEKAKLDRIQFRSLRAALGYSSSTPCNVILAEAKEPPLNIRFRYLTFNFLARASSREDHRILQILQEIMNLEDNPTIINRDGPVNLVECFRAIELHRHLIRSSSSPLCYSVGFEAIWYHPQVSFAEGEEISSSMRCQELFCDIFEEYLGGWTCIFTDGSKTENAPFGGFAVVLPLESIEIEFRAPKHASIFTLEALAIYESLKLIEESPFRCFAIFSDSKSVLQALVSDKALGKKSYLILVIKELSRKLSLRGKRIKLFWIPAHCDISGNEAADRVDKKAIYSGKDTNLHLPASDFKKMGKDLMWSEFHKWFMFTNTDKGNYYRNFYYTNNSKPWFSKFKLNRRSVVSINRLRSGHHSLNSCLAKYKIVQSPACACGAPEETPNHILFQCPLYESQRAGFIKALSINIGQGPYNVESLLSSLSQGIINCLSTFLSSIKKFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MSD2</accession>
    <name>A0A8J2MSD2_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS9072</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5099454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MSD2"/>
    <dbReference type="OrthoDB" id="7688248at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20898">
        <property type="entry name" value="DAEDALUS ON 3-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20898:SF1">
        <property type="entry name" value="MD-2-RELATED LIPID-RECOGNITION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5099454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="471" mass="53101" checksum="6033EB84E69A6B3A" modified="2022-05-25" version="1">MGEYVIDTGIDVTMDFCDSLEEPIILGPFFKGIGFDADNCPPGIGVYGSEGYQIPMEQLPDGFMPNNYKIILDIFHEDQNLIILHLFSKQGAYDLIIEDVTTAEYSEEYLNEPDIYVDDNFKLVINLTIVKQFPSTTAGRLSLMGASMGEYVVDTGIDVTMNFCEFVEEPIVIGPLFQAIGFDPNHCPPDVGVYGTENYEPITEGMPDDFPPNMYRTVLDIYTEEQKILILHIFSKINGSQLFNNKTASDGIEEPIMIGPMLQALGFTVDNCPPGVGVYQFEGYKIPKDNLPDDFPSNNYKVSIEIFYGEQKIIIVEVLMVKGDFDDVFVEDVNNPFYNEEYVTEPDIFLDNDNKIVLNFSIIKQPPEGTQGHFIIQRASIGEYVVDTGIDVTMDLCNCFEELIMIGPIFRALRFTADNCPPDVGVYQCEGYEVQKDTLPDDIPPYNYKVTLEIFYDDEMIIILEGFAKVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MSL0</accession>
    <name>A0A8J2MSL0_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DNA mismatch repair protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HICCMSTLAB_LOCUS12884</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="6 7">Component of the post-replicative DNA mismatch repair system (MMR).</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the DNA mismatch repair MutS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5107719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MSL0"/>
    <dbReference type="OrthoDB" id="121051at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032301">
        <property type="term" value="C:MutSalpha complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1420.10:FF:000005">
        <property type="entry name" value="DNA mismatch repair protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1170.10:FF:000002">
        <property type="entry name" value="DNA mismatch repair protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1420.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1170.10">
        <property type="entry name" value="DNA repair protein MutS, domain I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.110">
        <property type="entry name" value="MutS, connector domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007695">
        <property type="entry name" value="DNA_mismatch_repair_MutS-lik_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017261">
        <property type="entry name" value="DNA_mismatch_repair_MutS/MSH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000432">
        <property type="entry name" value="DNA_mismatch_repair_MutS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007861">
        <property type="entry name" value="DNA_mismatch_repair_MutS_clamp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007696">
        <property type="entry name" value="DNA_mismatch_repair_MutS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016151">
        <property type="entry name" value="DNA_mismatch_repair_MutS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036187">
        <property type="entry name" value="DNA_mismatch_repair_MutS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007860">
        <property type="entry name" value="DNA_mmatch_repair_MutS_con_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045076">
        <property type="entry name" value="MutS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036678">
        <property type="entry name" value="MutS_con_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003810">
        <property type="entry name" value="PRK05399.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361:SF148">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MSH6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01624">
        <property type="entry name" value="MutS_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05188">
        <property type="entry name" value="MutS_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05192">
        <property type="entry name" value="MutS_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05190">
        <property type="entry name" value="MutS_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00488">
        <property type="entry name" value="MutS_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037677">
        <property type="entry name" value="DNA_mis_repair_Msh6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00534">
        <property type="entry name" value="MUTSac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00533">
        <property type="entry name" value="MUTSd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55271">
        <property type="entry name" value="DNA repair protein MutS, domain I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53150">
        <property type="entry name" value="DNA repair protein MutS, domain II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48334">
        <property type="entry name" value="DNA repair protein MutS, domain III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00486">
        <property type="entry name" value="DNA_MISMATCH_REPAIR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 6 7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6 7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5 6 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 6 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA mismatch repair proteins mutS family" evidence="9">
        <location>
            <begin position="1005"/>
            <end position="1021"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="21"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="31"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="69"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="79"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="130"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="159"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR037677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS00486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAG5107719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="1154" mass="130616" checksum="441E65F08BCAEC84" modified="2022-05-25" version="1">MSKRPTQTNTLFNYFTSPKVPKKEDNKVTKVESNPKPTTPKRATNPKTKATVNGKENKEGSNTPKRKRQEKEKPKVDDESLEDVDKDEETPKKTKRRRIIIPSDESGDDSDEYKPGDEDAEDSDASISSGVPTSEADTTLDTQTEDEPTPQKEPIPKRNTGKVKKSWPAKKKIVDDDESNKSFQMQKAALPSGPASGNESWPHLKLPFLQPEKIRDAKERRPDHPEYDPKTIHVPKDFLDKQTPAMRQWWILKTQHWDCIFFFKVGKFYELYHMDAVIAVNALGLTFMRGEWAHSGFPEVSYGRFSSMLVEKGYKVARIEQTENPAMMAERCEKTKTTKFDKVVKREICQISTRGTRVATIQDTESFSAHSKYLMSIVEQQSSTQLSTYGVCFIDTSIGIFYLGQFEDDRHNSRLLTMLSHYTPVHVVYEKGNLSQVTMKIINTQLPTTTMKEALLKDSQFWSATKVLEKLHEGEYFKYESSEFSWPESLKPYLNERDTLGLSPADDKQLAVNALGACVYILTDYKLDQQLLAQKKFQTYVPPDMNVADGQNIGPLANMVIDAVAITNLNILRGSCSLLTILDHCCTAFGKRLLKEWICRPVCQKNLIMSRQEAITELIDLYHVCQDARKILSTLPDLERLLSKIHAHGNAAKLKSHPDGRAFMFEMGTYNKRKINDFVSCLKGFDQVLKIMKLFEPFESNLIVRTTQLEPNGEFPDLNGTIRHFERGFDAEAALEKGCIIPKKGMDIEYDKVIAEIEQIKIDADAYLKTQCRFFGASIKYTGTKKNAYQLEVPESQAKKITDRYQLQGQRKGFKRYWTEETRELLRRQTEAEEKREKVVKDSDRRTFAKFSEHYDMWATAVYKVAVLDVLISLAEYSRSGCMCVPEIVDTNEIMLDIKDGKHPFITSDNFVPNDTSLATNKYGPLVVLTGPNMGGKSTIMRQVGLLSIMAHIGCHIPAESCKLSLIDRVFTRLGANDDMITGRSTFLVELSEAAAFVQHATKNSLVLVDELGRGTSTHDGTAIAAAVLKALIELKCRTIFSTHYHALVEDFKNNPNVSPAHMACLVESEESDATQETVTFLYKLIEGACPKSYGFNAARIAGIKANITKRANELAKELEDAGNRRNLFISLCNVENNDVKDILNQMHTLKIKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MTJ9</accession>
    <name>A0A8J2MTJ9_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS7442</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5094904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MTJ9"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5094904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="104" mass="11868" checksum="B41C5FCEDD550587" modified="2022-05-25" version="1">MLIFKLYCKCCIKCILKIIEFFDIKLIFCFHVVKITHNLLADQSKMEQRFGALLLIIIILKALCPLIMGCPLSRTLTRHSRKLNTLAFIGNHDSATSSVSFKHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MTY5</accession>
    <name>A0A8J2MTY5_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Autophagy-related protein 13</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HICCMSTLAB_LOCUS9559</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Preautophagosomal structure</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the ATG13 family. Metazoan subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5100449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MTY5"/>
    <dbReference type="OrthoDB" id="70161at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990316">
        <property type="term" value="C:Atg1/ULK1 kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000407">
        <property type="term" value="C:phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000423">
        <property type="term" value="P:mitophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034497">
        <property type="term" value="P:protein localization to phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.900.10">
        <property type="entry name" value="HORMA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040182">
        <property type="entry name" value="ATG13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018731">
        <property type="entry name" value="Atg13_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036570">
        <property type="entry name" value="HORMA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13430">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13430:SF4">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10033">
        <property type="entry name" value="ATG13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0072">Autophagy</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Autophagy-related protein 13 N-terminal" evidence="6">
        <location>
            <begin position="72"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="256"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF10033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAG5100449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="436" mass="48295" checksum="8BC710B3743393AA" modified="2022-05-25" version="1">MSTMKLSMQDKKDLDKFMKFLAFKTAQIIVQSRSVHDLPEVLAEAKKVLCGEAISSSIPLCIEISLRTVEGDTMVLETWSLGVLPEQSDPTIRVTYTVYNRMGILLKSLLSISRVTPAYKLSRRQGPDSYVICYRIYMGEPQLHTLGDNYKHIRVGQLCTPVGTIHLSVSYRTKMTISPTHTSRDSIMLKSDHFHSDLSPRHARYQQRFEEISKSLSDTIKVGAFVVNKQVVVNEQDLVIPDVPFSSLLTPRQTSPPLGLIPDNISNPPTSTTATATSVSALTTGTAAGSVTTSTPLSSVVGATLDTNNGNNDKSSTIDNATFKCNSRNGSRRSSCSITSANDDFIMVDLKTPFAGTNTNSDLGTFYRECQSAPQLQTFLEEERTLAEQVGDLTKQLETFEINQQKYKDILTTLCQTDNNNQSTEFYLKSIKYSFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MU15</accession>
    <name>A0A8J2MU15_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS13980</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5109344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MU15"/>
    <dbReference type="OrthoDB" id="6515871at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="217"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5109344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="420" mass="48648" checksum="7EF42B1D1CE1C4DF" modified="2022-05-25" version="1">MQYLISEDNHRFYIRELKSIVQESEAIITVGSKVLFYDPENVSQRKQKLLSGIVIKMSRSEKLLKNELDKIVLQREKVQGKPDKSTPDKLSQKKFVQPAEKGKKINTKDPQKEVQRINSYRNMEYLQKNKPHWRFNLPFNQEFDEESQKANNPMLTDVLFKTNNIIDFLGCSTVTSSNTNYATNSQGLLIKHPTDLQQHHLFQFSNPSNSLECLTSDDNNNSSENCQQQISPVSTGHQSRVLDLRDSRQQNSEYHRNPSLISFYNHEASMLSRPKPKIMNTQNLSNQLQKLHPTQKVKNNYNNYRNPPTKNFQGLPIPSMGQSQIRTFPTMDPDNLPPVSMNKSTEESPTYRHNLSSAHFSHREPHQTSQVYYNQPISHKNGSSAVNNHYDLPQYRQHSSEHEYAAIADPEFYEIPSEQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MWB0</accession>
    <name>A0A8J2MWB0_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">THAP-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HICCMSTLAB_LOCUS9669</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5100596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MWB0"/>
    <dbReference type="OrthoDB" id="7695469at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027806">
        <property type="entry name" value="HARBI1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006612">
        <property type="entry name" value="THAP_Znf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23080:SF143">
        <property type="entry name" value="SI:DKEY-56D12.4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23080">
        <property type="entry name" value="THAP DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13359">
        <property type="entry name" value="DDE_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05485">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00980">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50950">
        <property type="entry name" value="ZF_THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="THAP-type" evidence="8">
        <location>
            <begin position="1"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="115"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="120"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAG5100596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="406" mass="46146" checksum="D0006124BBD565C3" modified="2022-05-25" version="1">MSRSVKSCCIKGCTEKSRRKWQVDTPVKFHCFPSSKCGASWKEDKRIKWINAVKNYVKNPKQWEPNQHTRICSAHFINNSKSDNAYHPSYVPSIFPGKENKKNSIQRLQRFERSRARQLNNINSSENSSNSIKGKNIDNSSDIEMEQDAGEMIAEAQDGCRRDMNVSPPAYRSITCQTEELIPGISSDSCTNFFCNMNNHGGINTAAVQVNISVKKTVDKMCEASMPCDPINFESVQSHCKGFHGFSSITSNETMGSLTGLLNKLPESKRSDIDKKTKLLITLMKLKIVLFNIHRTTVNKIFIKNLQQLNILLKNFIFRPSKAAVQATLPESFKLHYPDTREVDETYNIASVRIHIERVNQRIKDFNILSKVPVSLLPHVDEIVFVICAIINIQKPLFKQEKSATE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MWU2</accession>
    <name>A0A8J2MWU2_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS10077</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5101004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MWU2"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5101004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="16" mass="1913" checksum="EC2CA099B70E06C5" modified="2022-05-25" version="1">MKILFLWHAKGLKSLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MX09</accession>
    <name>A0A8J2MX09_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Short-chain dehydrogenase/reductase 3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Retinal short-chain dehydrogenase/reductase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HICCMSTLAB_LOCUS11069</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the reduction of all-trans-retinal to all-trans-retinol in the presence of NADPH.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5102546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MX09"/>
    <dbReference type="OrthoDB" id="4321958at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052650">
        <property type="term" value="F:all-trans-retinol dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05339">
        <property type="entry name" value="17beta-HSDXI-like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000131">
        <property type="entry name" value="Short-chain dehydrogenase/reductase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24322">
        <property type="entry name" value="PKSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24322:SF736">
        <property type="entry name" value="RETINOL DEHYDROGENASE 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00059620"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00068717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00082544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAG5102546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="506" mass="57155" checksum="55D802139981A0A9" modified="2022-05-25" version="1" fragment="single">MINKLGILIGIVMMQQHIEVNAWGGLFNRFTPEMLSNLGYGGHSGGYKPSYMQRPLTGNYANNFAEGLETIDDLCEDRRCVSNEYCCSGQICIFDRDNEGFCVYPFGLKQGELCRRDSDCETGLMCTDVIGADTRSCQPPITSNKQYSEECTISSECDITRGLCCQVQRRHRQSTRKVCSYFKDPLVCIGPVATDQIKSVVQYTSGEKRITGQNNRILFKRDTCLLLFKIIYYVIESAYRLIVPVEEKNVAGEIVLITGAGHGIGRELAYKYASLGAIVVCWDLNAQSNQETVTEIMKLGATAAHAYQCDVSDREQVVKISARVKSEVGHPTILINNAGIMPCEKFSNYSPETVKKIMDINVLAHFWILEEFLPMMINNNYGHVVALCSIAGIIGLKNLVPYCASKFAVRGLMESLHDEVNWIENYPKNNIKFTTIFPYMVDTGLCKKPHMRFPSLMALVPPKEAASLIVTAQRRNFIQVTIPRYWNTVISRKSWYRNKRIFKQRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MY17</accession>
    <name>A0A8J2MY17_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Similar to Kappa-scoloptoxin(11)-Ssd1b (Scolopendra dehaani)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS12295</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5106508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MY17"/>
    <dbReference type="OrthoDB" id="121932at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008047">
        <property type="term" value="F:enzyme activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007586">
        <property type="term" value="P:digestion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.20.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017915">
        <property type="entry name" value="Colipase_CS"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00121">
        <property type="entry name" value="COLIPASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5106508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="246" mass="29066" checksum="976D04B94D9A76F8" modified="2022-05-25" version="1">MRDCWPNRLKLTRQIMWKISCLVFIFPALCQSNYTRISSKPSSIIFKYLEGTTGELTLDECGKDQVCNVVHRRFWMPNLAERLCRCPNGEECPWSEETDNSSIVLNNRSILKFCQPITEKQLCKPRQIAAVVRGVINDENTHMIPQNVTVNCICPSTHYWRLKKYEFDENQLYQAYKCSQQRICYSYEFCGFVRPDFYSIYYRCSCPKGNLCITEYKESDQVQEFMYLGIAYKAHCDPWNKTSRIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MY78</accession>
    <name>A0A8J2MY78_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Similar to prpf39: Pre-mRNA-processing factor 39 (Danio rerio)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HICCMSTLAB_LOCUS12565</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the PRP39 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5107059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MY78"/>
    <dbReference type="OrthoDB" id="10265668at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000243">
        <property type="term" value="C:commitment complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071004">
        <property type="term" value="C:U2-type prespliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030627">
        <property type="term" value="F:pre-mRNA 5'-splice site binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000395">
        <property type="term" value="P:mRNA 5'-splice site recognition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000063">
        <property type="entry name" value="Pre-mRNA processing factor 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003107">
        <property type="entry name" value="HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059164">
        <property type="entry name" value="HAT_PRP39_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17204">
        <property type="entry name" value="PRE-MRNA PROCESSING PROTEIN PRP39-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17204:SF5">
        <property type="entry name" value="PRE-MRNA-PROCESSING FACTOR 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23241">
        <property type="entry name" value="HAT_PRP39_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23240">
        <property type="entry name" value="HAT_PRP39_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00386">
        <property type="entry name" value="HAT"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="86"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="699"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1024"/>
            <end position="1128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="19"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="98"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="133"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="164"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="209"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="238"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="264"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="284"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="306"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="333"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="357"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="701"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1061"/>
            <end position="1100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1110"/>
            <end position="1122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG5107059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="1137" mass="130499" checksum="4ADA127DA73BD03D" modified="2022-05-25" version="1">MSSMSGDENELMENESVRRTRSGRALKTPVKKTPIKKPATRTTRARGKAVVETEAVEECTTVIEELEEDSAPGNGMQEFEQVLIESNEESASSAQFENSEEVIDPQEETQYDHLDQETQGVPELEAPPPPIVSNKTASTPISSTLRVKESVQMTEDESDVITLEDNSGDNVIQTQDDNPGDEGMNGGHVEENQINDINEVIDEMKSNEAMEEETDVTIQEQTDEPMEVNDTVQEVEEKDEKDAGDNDNNEEKIEEQAENPQPETEQEVDPTQVDEEGEKKEPDTEAVSEDEFPTEAAAKYLHDVEDVSDDDFSLETEAVSDEELPAAPPADLGETESVSEDELPPESEKKRKAAAKASEKTREKKVKVEAGTKRKLNAEGEYDPNSPTSETNEETPAKKAALATDTETEEKTETAPPSPKKKTLPELDKYWKAVIEDPSDFTGWTYLLQYVDQENDAEAAREAYSKFLERYPYCYGYWRKYADYEKKKGNPDNVQTLELGRRVGSVHARKYGFPFQQPSTSCGTHSALFVYELANYLIMISTIIKLFKKFIQMRLRNTVLLSLPLLSLFYELNYVFDNGLQAISLSVDLWLHYINHCKSIYEEDEEKMREQYERAIEACGLEFRSDRLWESYIKWETEGKRFSRVTALYDRLLCVPTLGYMTHFESFQEFVSVNSPNRILNVDDFLALRAEVKAMLKAEETPAAAPTDDAPPGEELPPHEAPPTDEETRAIREKIISSRRKMHKANVNAVAARWAFEEGIKRPYFHVKPLERCQLKNWKEYLDFEIEQKDEKRIIILFERCLIACALYDEFWLRFIRYLESLKGDNVEKIRDVYVRACEIHHPKKPNLHLQWATFEEGRNCFDKAATILENIDNVIPNMLQIAYRRINLERRRGDLEKACTLYESYISNSKNRTIANNIVVKYARFLCKFKNDIDKAVKVLLKAADKDKENPRLYLQLIDLGLQRNPVDTKEIIGYMDMFIEREHVDLEQRVLFAQRKVEFLEDFSSDINQVLQAHEQFQQCIKQAKERKKTKNEDSKIDSSPPKKIKTTDPSSAPPPPTANTQSTYQYSSGTSGTYPSQQQFQSGQYTNQSGYQQSYQQYPPPSDPNYANYQNWQYSQSGPQAYGPYNQWGSYNYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MZ96</accession>
    <name>A0A8J2MZ96_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Similar to Las1l: Ribosomal biogenesis protein LAS1L (Mus musculus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS12539</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5107008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MZ96"/>
    <dbReference type="OrthoDB" id="10263222at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090730">
        <property type="term" value="C:Las1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000460">
        <property type="term" value="P:maturation of 5.8S rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000470">
        <property type="term" value="P:maturation of LSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007174">
        <property type="entry name" value="Las1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15002">
        <property type="entry name" value="RIBOSOMAL BIOGENESIS PROTEIN LAS1L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15002:SF0">
        <property type="entry name" value="RIBOSOMAL BIOGENESIS PROTEIN LAS1L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04031">
        <property type="entry name" value="Las1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5107008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="646" mass="74895" checksum="3DB3A7ED6EDF2CA8" modified="2022-05-25" version="1">MALLAKNENLKLVPWFSLAEWHQVYKQIYSNDTQAQTKGYETLLVWKARMPKLPVGVDCTLSLMQVCLRDRDWSPKINNGELPLSYENDLCLLYSTTIMKFLNHIANIGNTRHTSLFKIARQLNIPKWIVHLRHNAAHGHELASIELLRTAANVLLSWVHDEYWTAQGKKSIDQQCSRDFEIPDSEETAEARVLVDLIELWIAVGLYMAVDYHSVSDLPDEHLRDTLNDLKNYSKKSRNSLNEKKDNSDSDYPLSIARLYLLTDIFTILSRYKTSYDKTQVVLNILFKNEAFLPTSDFLNLLISKSESTETTDYSCLPEVMIKLWQPFIAMLHERKMLEALTLKLIDFTKSSVDNHRRLCAALWINAVAQGLIKIKIAQDKIQVFEHSMLKNNKKVNPKLLEMKLKEELNKSHPELEHALWLNFMSDIPPMFININFASDLAINVNEFTIKFIEPILDLVEPRIDAEKKTQLLSIIRIHRHTNTDDKNNMDSDRISSQHNFNKIYTIEDVKKITGNEFNHIGHSSKNNATCEKIDLADMKIRNTNWELASDKYNWKSSDFGILPWQIDNLERIESKDVTPKLLYPSRESDIIPGIIDSKTIMSCSQIDWDTVLLKKKQRVKRKRKNNDADDMINKAIEIVKTKNNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2N0S6</accession>
    <name>A0A8J2N0S6_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">OB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS13920</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5109284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2N0S6"/>
    <dbReference type="OrthoDB" id="7551505at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5109284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="325" mass="36793" checksum="519649CE5FA38F56" modified="2022-05-25" version="1">MSDETVIASALKNFSRNSKSDDKDNNQDGSETEDGEFGMSTQFDNINTDDIESIASDTPEKIEISSTEYLKNIPLWSSTIEIVGRIEEIVASKEITFQKTGGKGTVFKFVIANDDGTRIKILSWDDEINRVIPFISIGSIIHIDGAFSKPIDSKSRCYNSGSVDIELKVESNTKINVLKRMSPREVPTLETFQYPLITIEDCEQYIQKKIRFQGWTKTNFDVVKLRTDDSFKCCGSIAVGDGYKIEIKLINFQQPFESPFSKGDHVEVTGIMKNYYGRAMIMIDSIDAVEIIDGCKMSLSLLIKSNKEIKFQNQEEFPFKKQRQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2E0R5</accession>
    <name>A0A8J2E0R5_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS366</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001114">
        <property type="protein sequence ID" value="CAG5073423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2E0R5"/>
    <dbReference type="OrthoDB" id="7635497at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5073423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="434" mass="49651" checksum="B4D1237EDACB3F8A" modified="2022-05-25" version="1">MNKTNSKCFICKKRTDKIIVFSEETLQKYKNILKIRQDNNLHYSDVELPENVTQTDGYHSQCYRPFSALMKYQIEKTVGASPQPSTSSTGDSLICEDAKKTTSADETPPPPVNIENVETSQENAEIHTSLQHFEHSENKDATAINTNVCLFCTKSSKKWKGQNQKLCDLDVVSLKVAIEPFLSFVSDTEIFNKLQEVQESTILKAHRICRKEYINSLQSFVDKPQTTFHKNIQFHKEGFKNICQFINSNIISKKKCYFFVYLCDFYEGSIKDAARKYGHVYDNTLSKANFESKIKKHYEGQLKFSIFPNKKIVGPIDRVIDENLYSLLEEKSILHSAALILRQKIFEIEKQALPEEIKTEDLLKGECNIPETVKDFYLTVLAGSHSKRRKSFDSYRLKLKTRGFLIANHSARSSGPGSCQHASTSYLCRTYGSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2E1N7</accession>
    <name>A0A8J2E1N7_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Succinate dehydrogenase assembly factor 2, mitochondrial</fullName>
            <shortName evidence="4">SDH assembly factor 2</shortName>
            <shortName evidence="4">SDHAF2</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HICCMSTLAB_LOCUS912</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="4">Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit of the SDH catalytic dimer.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Interacts with the flavoprotein subunit within the SDH catalytic dimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 4">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the SDHAF2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001114">
        <property type="protein sequence ID" value="CAG5074140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2E1N7"/>
    <dbReference type="OrthoDB" id="284292at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006121">
        <property type="term" value="P:mitochondrial electron transport, succinate to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034553">
        <property type="term" value="P:mitochondrial respiratory chain complex II assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.250:FF:000002">
        <property type="entry name" value="Succinate dehydrogenase assembly factor 2, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.250">
        <property type="entry name" value="Flavinator of succinate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03057">
        <property type="entry name" value="SDHAF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005631">
        <property type="entry name" value="SDH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036714">
        <property type="entry name" value="SDH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028882">
        <property type="entry name" value="SDHAF2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12469">
        <property type="entry name" value="PROTEIN EMI5 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12469:SF2">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE ASSEMBLY FACTOR 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03937">
        <property type="entry name" value="Sdh5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109910">
        <property type="entry name" value="YgfY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2 4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAG5074140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="143" mass="16817" checksum="182ED5AB82FFF481" modified="2022-05-25" version="1">MLRLNNFNRLVRPTLQIVGVRSNSEIHHPPGNEPAIPVYVPRLQEDIKLKKARLVYQSRKRGMLENGLVLSTFAKKYLDTFNEKQLALYDELINLPSNDWDLYYWAIGMKPTPAEFNHEIMDLLKTHVRNDDRQSRIVQPDLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2E5T4</accession>
    <name>A0A8J2E5T4_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS959</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001114">
        <property type="protein sequence ID" value="CAG5074202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2E5T4"/>
    <dbReference type="OrthoDB" id="8190053at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="63"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="89"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="115"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="143"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5074202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="178" mass="19463" checksum="7BC14EBD513D00EA" modified="2022-05-25" version="1">MGIKILEKCCCFDLKTGVLVIGILSIAVSIGGLIEAPISYSQACSGTRTPDNDDNCATASSTLGASISSEVIGIILMGLMIYGSQRESYGLMLPIIILQAIGIFLIFLFVWYLTIIFFIVSFGSGLLFMILANQGLGQCLRDNEKLRQEVTALKQHVQRLQRENDQLRKVNVVVSNIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2EA37</accession>
    <name>A0A8J2EA37_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS237</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001114">
        <property type="protein sequence ID" value="CAG5073236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2EA37"/>
    <dbReference type="OrthoDB" id="7634102at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="173"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="328"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="403"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="173"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="232"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="244"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="328"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="424"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5073236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="497" mass="56495" checksum="12F0FF3F6C57F0A0" modified="2022-05-25" version="1">MDLRSDKPCTAGRIAPTGRLTPSIHQSVNGKRKVIPVPPPRIPTPMPIVNNNKQRNSSNVQISQIPPVQKKESHGNIGKIARRYLDDNMQQVWINPRLISMINMEAVTSTDYDSANLSHNFNQIGFSTYNYSQFEEKYKSTQQNSTKLGTISQTLSSQSNDFVSYLYDDKYPRNQLKSERDSNKQHSYLLPHEVKSKSQNLRGDLTYYQIDPPGKHDTRHSKCHRSDDKNISYETHATTIVTDDNNKKDGKDENNKRDKSGKHTHVNKSDSKINNGALSINQQFIKSTTNESDDECHLSHIGQISSNQHHHQQQQFQVSYKYRQLDRPPKYQEYPPRDSLRCEQPAPRYYQDPPKYSDVIRRDDLKKIPEEKGRRQVGIRSGSVGETPVNLVSITPTTREVTRGAMTRHRQTNKQQQQQIIDDSNQVTTDNSKEPTTQHNFTEQTTAPPGLTTITNSSMTTTTITSTTTTTTTSKTDQSCRNNFNGGIILGVNVSGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2EB68</accession>
    <name>A0A8J2EB68_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DDE Tnp4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HICCMSTLAB_LOCUS1728</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001116">
        <property type="protein sequence ID" value="CAG5075574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2EB68"/>
    <dbReference type="OrthoDB" id="6627079at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027806">
        <property type="entry name" value="HARBI1_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13359">
        <property type="entry name" value="DDE_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE Tnp4" evidence="3">
        <location>
            <begin position="23"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG5075574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="183" mass="21296" checksum="ABF03F2ACF03E49A" modified="2022-05-25" version="1">MGQKFENREMNLPEAELLTVDGMPLPYVLVGDEAFQLTDYLLRPYPGRGSLNKDKTIFNYRLSRARQTIENSFGLLVSLWRILKKPIEATVDNSVNIVKAIICLHNWLRKQDEENNYIQENMVDRQGENGFIPGRWRDEVGEHSTLQDSRIYGNHYSSRTAVTIRDEFCDYFTAEGAVPWQYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2EHU1</accession>
    <name>A0A8J2EHU1_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS113</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030000678">
        <property type="protein sequence ID" value="CAG5071964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2EHU1"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="55"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="118"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="55"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5071964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="270" mass="31242" checksum="FF894623915F6F11" modified="2022-05-25" version="1" fragment="single">LRKRWNDNEKRVRVVKKPYTPPVNSSKLLGDAKENMDDEAKKCYYKILAVNEKTPPKTKDKTNALHDGGIDRGNQVGSKTPPRAPLTIPSKSDSYLEGSDAGVITRDRMQNIKRVAWKRRMESRYLNLREEVNELKRSKNENNNKNENNEDKTKSVKLKETIVIENGEQITTIDDVVFTSTEFVTIAKQPTMKKRVSCLVPVVWTQEVIQKKYLNPQLCYHFQKHRKINYETGGKDDPNFHSKPWLGRRCTELRNVLNQKNKVHQAPPDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2EI71</accession>
    <name>A0A8J2EI71_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Similar to ZMIZ1: Zinc finger MIZ domain-containing protein 1 (Homo sapiens)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HICCMSTLAB_LOCUS531</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001114">
        <property type="protein sequence ID" value="CAG5073628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2EI71"/>
    <dbReference type="OrthoDB" id="27975at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061665">
        <property type="term" value="F:SUMO ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016925">
        <property type="term" value="P:protein sumoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057847">
        <property type="entry name" value="ZMIZ1/ZMIZ2_GBD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004181">
        <property type="entry name" value="Znf_MIZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10782:SF4">
        <property type="entry name" value="TONALLI, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10782">
        <property type="entry name" value="ZINC FINGER MIZ DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25527">
        <property type="entry name" value="GBD-like_ZMIZ1_ZMIZ2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02891">
        <property type="entry name" value="zf-MIZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51044">
        <property type="entry name" value="ZF_SP_RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SP-RING-type" evidence="6">
        <location>
            <begin position="544"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="708"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="767"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="856"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="708"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="802"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="869"/>
            <end position="882"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAG5073628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="890" mass="97335" checksum="0DAA862BD24DC44C" modified="2022-05-25" version="1">MVAAATATAIATACVVAMQDRQDIPSQFNQGQHGMPHQSYNTGYGQRGGPMGGMGPTINSYNGMSSMVPVQPMNSMNSMNTMNAMNGGMNPMSMNGMNGMNGMSPMSPMNGMGTVNNNMAGMNSMMPNAMQINKMNMQQAQAQQTGYPRRLAPYPNPQMHMVQKRQQQVGYANVPPNPMQQQQPGFNTMPNNIQPNQYPPTNYPSTRPPQNFHPQYQPIQGMGNPNGGFPPNPMIRGSNMRQQTPNYNPVVSQSSNQYYGSNSPSGVVGHPSPVVNMGNGMPSHQQPHQQQFIHQQQQQPNPTGYVNTSYPTNGQYTSDVSIRASGAGNMNYQHSPIPGNPTPPLTPASNMAPYISPNSADIKPNFNELKSTVMSQKDEELRLTFPVRDGIILPPFRLQHNLAVSNHVFHLKSTVHQTLMWRSDLELQLKCFHHEDRLMNTNWPASVQVSVNATPLVIDRGENKSSHKPLYLKDVCQAARNTIQITVSACCCSHLFVLQLVHRPSVRSVLHGLLRKRLLTADHCVAKIKRNFNNTMSNNGMQSEKDVVEQTALKVSLKCPITFKRITLPARGHECKHIQCFDLESYLQLNCERGAWRCPVCTKPAPLEGLEVDQYMWSILNTTSSTTVDLEEVTIDAAAKWKPSKPTNMVTIKTEEDLDCKRMIKAMSPGSMNMPTMMNYEMNQAMSPYIPPDMNSIVSGSMMNNTPPTYVNNNINHRNSSGGSYDINSGTPNSNNDYSNGAGPLTHLNDSVNSLDQLNAMEKSLTDQMPHTPHTPHTPHTPHTPGGGNSGPPSVPPASQESTGNLNTSGNSTTNINDSTDIPSDLNFDPAAVIDGEGTGQEALNLLPDNVVDPMELLSYLDPPDLNTPPSSGASSGNPSSSDDILALFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2EK03</accession>
    <name>A0A8J2EK03_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to spop-b: Speckle-type POZ protein B (Xenopus laevis)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS1456</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001116">
        <property type="protein sequence ID" value="CAG5075302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2EK03"/>
    <dbReference type="OrthoDB" id="10249567at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030163">
        <property type="term" value="P:protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.710.10:FF:000159">
        <property type="entry name" value="Speckle-type POZ protein B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.210.10">
        <property type="entry name" value="Apoptosis, Tumor Necrosis Factor Receptor Associated Protein 2, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011705">
        <property type="entry name" value="BACK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002083">
        <property type="entry name" value="MATH/TRAF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008974">
        <property type="entry name" value="TRAF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24413">
        <property type="entry name" value="SPECKLE-TYPE POZ PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07707">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22486">
        <property type="entry name" value="MATH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49599">
        <property type="entry name" value="TRAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50144">
        <property type="entry name" value="MATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MATH" evidence="2">
        <location>
            <begin position="25"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="207"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5075302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="378" mass="43441" checksum="30860E6ED1AC59C0" modified="2022-05-25" version="1">MSVDSKINLVDKKKARGYSHLEMHSIVYTWEINKITHFLESTKGIEENVINSPEFSTSAKLKDSWFLQLKIQNDDQSSKNETWVSLSLMPKHKNLKVRAKYLLFFLNNKKEKIVSGGKSYNQSLDAWISHHFVSSPAGRGFSNFMKIEDLLQNKDELLKNDTLTVCVDLIIYDEYVTQNNPITNSLEDSDGTLNKDFENLLISKKNCDVVITVGDEKFDAHKVVLITRSNVFEAMFEHDMKESKKNEVDIPDVDPGVFRRVLEFIYTDKVEDLDSFADELLEASDKYQIHGLKKMCETSLSKTLSFKNAVRILILADRHSAERLKEFTMDFVVANLAELQNTEEFKRLEKSQESLAYAVLKKFIGEIQTNNDSFTAAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2EM50</accession>
    <name>A0A8J2EM50_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS454</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001114">
        <property type="protein sequence ID" value="CAG5073511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2EM50"/>
    <dbReference type="OrthoDB" id="9995573at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5073511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="357" mass="41536" checksum="2C11752C3BFD47EE" modified="2022-05-25" version="1">MNVSIFTKSLSEAAADFVSKLYSLPDLSRTNVQELLNAFTIFLQTEPFNMLLNDMIQKCVFLGDSSQSIQVYKGMFIPLRNVLKEIFELPFIFNDSREYLQNLEENDVLIKNVVQSESWKKKKATLGEKLVFPIFMYQDDYETNNPLGSHKEGLYYGDESRNKPRTLKPNQIKTRFIKMSASESRCFLENIGVLIGDWVPRKNLHWRLVILIKEIFDIVSATVIHKGISYYLTNLIGEYLHLLSILFPGSLKPKHHYMLHYATIMERKGPLWNMNCMRPESKNRDSKITSRITLNRTNISKTLAIKSQLILNHRLRNRLVSNKLYESNKSTLKSVPELQEYCSYAKLLSFSHGEKFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2EM78</accession>
    <name>A0A8J2EM78_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS529</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001114">
        <property type="protein sequence ID" value="CAG5073624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2EM78"/>
    <dbReference type="OrthoDB" id="8196194at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="145"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5073624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="193" mass="21176" checksum="FA96F641F81438E8" modified="2022-05-25" version="1">MGGRHSKRSMDVTTTPKKDGIPAEGDAPAVGDGKLERIEEADANTKPTTNGVAPHTDAPEDKDNVNEKESTTEKEKEKDDDDKKTADESKPETPATESPVEGEQVTTPTEETPASPKEITSPDTKEAKKKDKTKKKWSFRSISFSKKDKSKPVREDSPKNGDVSKEEPLAEVFTILFNLNSYTPTLNIVCCIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2EMK2</accession>
    <name>A0A8J2EMK2_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS832</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001114">
        <property type="protein sequence ID" value="CAG5074060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2EMK2"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5074060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="227" mass="25874" checksum="452304587C56A7D1" modified="2022-05-25" version="1">MTNSDLNRLLEFKRLYSFVELNEFRIACFNLVAFRLATSLAFQWMKDYSVVTSGTEVLLAFGIVGHVIVCQNNPTIIKYHHPKQLNSKSVLLNYEIDSDIEKTVKATRRRGVMKIILDPNDGLLVPIGPGPGIEPGSFGYALRARTVKLSETSPATTFQSPNTFLFNTIKKYLLKYSRYNYLSILNKGLIILINYNSEIRKIIRKTRTGDRTWILWVRTKGSDSCAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H0F5</accession>
    <name>A0A8J2H0F5_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS2007</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001116">
        <property type="protein sequence ID" value="CAG5076026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H0F5"/>
    <dbReference type="OrthoDB" id="10291986at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012674">
        <property type="entry name" value="Calycin"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50814">
        <property type="entry name" value="Lipocalins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035173662" evidence="1">
        <location>
            <begin position="19"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5076026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="186" mass="20960" checksum="595A03F983743620" modified="2022-05-25" version="1">MFFVNIAVVFLLVGVSSAQTEQPIKCLNITGADYDFYQGAGLWYIYASTYDPFEDALRCLTHNWFYPDGDNVARVIVSGIFKKTGLLSQIEAVYTMYKPDNRLHSKSWDPLHGVLSHDLWDLEDVYDDYIVTSSCVRQGSSIVPTFTILTREPYPTTDVIGRAREIITGGLGLAEPNFFIYDTNCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H0H5</accession>
    <name>A0A8J2H0H5_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to lrrc28: Leucine-rich repeat-containing protein 28 (Xenopus tropicalis)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS163</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030000873">
        <property type="protein sequence ID" value="CAG5072608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H0H5"/>
    <dbReference type="OrthoDB" id="2021138at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050216">
        <property type="entry name" value="LRR_domain-containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051:SF1">
        <property type="entry name" value="RAS SUPPRESSOR PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00364">
        <property type="entry name" value="LRR_BAC"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5072608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="249" mass="28745" checksum="67F8A4B498233DB4" modified="2022-05-25" version="1" fragment="single">MEELIEEIKSKKILHWNYRGFEELPSVLKHHGHEVCEIYLKENKLTCLPPWICDFSNITNLYLSGNKLSKFPEELSRMNQLLVIDLCDNNIEVLPHSIQNLSSLRQLLLDDNYLNQLPVELLKLERLEILSLSRNNFITLPEWLGSLKKLDKLIVDNNNLEEIPNRLTLACSLTAISVKSNRLRYLPLNSFISPVNIIFDCNPNINYLSYPILCQLLELGWEDGKNCLINGCKLAMSVNKNIKLLVNLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H0N8</accession>
    <name>A0A8J2H0N8_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Large ribosomal subunit protein mL64</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">39S ribosomal protein L59, mitochondrial</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Growth arrest and DNA damage-inducible proteins-interacting protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">HICCMSTLAB_LOCUS2369</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Acts as a negative regulator of G1 to S cell cycle phase progression by inhibiting cyclin-dependent kinases. Inhibitory effects are additive with GADD45 proteins but also occur in the absence of GADD45 proteins. Acts as a repressor of the orphan nuclear receptor NR4A1 by inhibiting AB domain-mediated transcriptional activity. May be involved in the hormone-mediated regulation of NR4A1 transcriptional activity. May play a role in mitochondrial protein synthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the mitochondrion-specific ribosomal protein mL64 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001117">
        <property type="protein sequence ID" value="CAG5077093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H0N8"/>
    <dbReference type="OrthoDB" id="6247992at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.280.120">
        <property type="entry name" value="Growth arrest and DNA-damage-inducible proteins-interacting protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018472">
        <property type="entry name" value="Ribosomal_mL64"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043035">
        <property type="entry name" value="Ribosomal_mL64_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31761">
        <property type="entry name" value="GROWTH ARREST AND DNA DAMAGE-INDUCIBLE PROTEINS-INTERACTING PROTEIN 1 GADD45GIP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31761:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML64"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10147">
        <property type="entry name" value="CR6_interact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="225"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="227"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="258"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00035184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00035485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00060144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CAG5077093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="269" mass="31821" checksum="FBFB866FE96249AB" modified="2022-05-25" version="1">MNSSSLLLSRLTINGLPRILSRRWYVKEEWKDESIDITSVEETPKYGEFLTEEQEQEILQKRNKSKLNNFDRNKLHGLKPHNQNWDWYHNSVRYKQRMLGRHGIEALDVPAGCVWPIKEEVEDRLEWEKTAYPNSLWESWDLIAQKNKENAEKILKREKEIDAKLMKVSTWQKDLEAKLAKKEAEIRAIKERKDRLVAEVRRAVGFDIDPRDERFKQLLEEKEKEDKKRKKALKKQAHAAKTMERLLTASNSLNLKNKPAEESAKSETS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H2M3</accession>
    <name>A0A8J2H2M3_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BEN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS1521</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001116">
        <property type="protein sequence ID" value="CAG5075367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H2M3"/>
    <dbReference type="OrthoDB" id="7692610at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="304"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="309"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5075367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="379" mass="42337" checksum="2E427F1688986D6E" modified="2022-05-25" version="1">MISGYPNSATSTSLIPSQPPFSYNSQSSKIFMHNSLSQANTMQFTGVNPVLAGPVLASSLTSSDDNSGLRKSSSPTSQRKLLENDNTTDSDVNRHCFKSPSNKVHSMGTENKENNGSETDFSDGDDSTDHKSSSGDNSSGDDGEILSRMELGIVTSRDIFFQEQLLKAMKSKHASQIKAKNESNKTIPIEEHYYKPRNPDEKVEISENSGFYLSRVRASIIETNAVCRNDWNLMIKETLEDIYGSNLFKYCAKGKTGKHPGIDPNLFKGLFEWVNRKFDNKITDKMFTQRVARICDNKRKYKARKVHESTSNPMKHITSSLSKPCTVTSDQVKSKTKTKSVDLDGGNTSQKDDNSPVNLAKKPRSKHHGYQDTITRNYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H5J0</accession>
    <name>A0A8J2H5J0_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS906</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001114">
        <property type="protein sequence ID" value="CAG5074134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H5J0"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5074134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="70" mass="7800" checksum="2194889F80273F13" modified="2022-05-25" version="1">MSPKLADSVAVLSRVFWTSSKAALISRTIITTPVSFCRSRVFWTSLRAALKSRTIFPTSVSFLGSVYRSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H613</accession>
    <name>A0A8J2H613_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS2542</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001117">
        <property type="protein sequence ID" value="CAG5077726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H613"/>
    <dbReference type="OrthoDB" id="6381867at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37970">
        <property type="entry name" value="PROTEIN CBG08587"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37970:SF1">
        <property type="entry name" value="SERINE-RICH ADHESIN FOR PLATELETS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="237"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="400"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="554"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="600"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="59"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="80"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="257"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="291"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="334"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="429"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="447"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="473"/>
            <end position="484"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5077726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="1034" mass="115481" checksum="35789C8289175D8C" modified="2022-05-25" version="1">MEDANCVDFPEALTEVIGYGGDYIYSDEESESECYDQEKSKPDEHVPENDEDRALSNLTRANTNFNRTTANIVDAPSAPPSSSSSSSSLSTSTEVKVLPNLMLGTPQKGNDGKKTTLLVSVTPFKSDSAVGPAKLDRDWLDRDVTGKNWIDMTATTAITDKKAKIVLDKIVDMPLIESNNLISMTKKLTCDKPEIKYSKPVDLGKQTVDKGFKSHNETTSNHNQVIVNKESVNSEEIAIPDLGERTIEGESTVVESENVKKETNHDGDNNNDRDKSILNGNGNNNDNNDDNNNKSKNKDCDVNDNNVNEELLMENSREDAGAPDGKAADDETSESSCSLTHVSTIPRSSFLHGETTKSVSSSKSADDEVLSDSCKNKNFTTEITSSEDDKLVAKETVKTKITGKRKSHDCGSQRRQAPKPPDQMEEESLSTLFARNPVTSVKSDSPVVREKEKRERATSCSPKFSRTEDDESMNNPTYSGHINNDISRKSVSLSEYSLNSYSRESLAGDNAVQDRDKKKGKSRFSLKKLLRIGASRKEMNITTCSHTFAESFDDDSGSIKITPSPSSSPREQANCKSRPEIIHPLEFNGAAVEVLRHDKLINSPNQSSGRTDACPDKSRYSQTVAHLGKPPSPPKNIQPSKNYLHSLMKKTNPSPPLKDHKKLDDNWKASNNLTNDAIYANLDNERQWKNHFESCLRQRRGRNIFHRNLEDNYNALVIANHESLAQLFQQLVQENQLSVSCIKRTNLQLNEFNINVDTIKKIGCRIFCSATWNSNQVILCFSSGGLTSLPTYREFFIVPLVEFVDSLPDNLFNNYTEDISHENVTVSVLTYTQVATISSYVTSIRQNCENIFQQSCLVLLQLVNALKNLQARGIEEFPKSLSNVVLCQEEKTLSWRLYLLQNLHIDVNDGEDCASLCQCALEALKMLDLTNKFPIIKQLLIRERAVSLSQVKAVLEYSLWGPPHSVFGALKEREVILQRWLDLERANLLHALIKKHTPLTVSDEYQLAFLIHTTGKIMCEASVLLDQQNSDSKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H654</accession>
    <name>A0A8J2H654_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS2624</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001117">
        <property type="protein sequence ID" value="CAG5078027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H654"/>
    <dbReference type="OrthoDB" id="7989680at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5078027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="161" mass="19037" checksum="35EED60F209C2DDA" modified="2022-05-25" version="1">MEKIRVLDRKCIRTCLRVYRSRESNFKKQISNETLYNIANIPRIDNFIIKLKRDYFAKLSSIENKEIEKILETPDQQIYITNHNSACLPPQAFIYFDKKGIIQDSNNVPTIYHWGRNVANKRINLITDMIANNKYDPVYSIWPYQNEIKWTSTVLMKDTGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H6J3</accession>
    <name>A0A8J2H6J3_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HICCMSTLAB_LOCUS2892</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001117">
        <property type="protein sequence ID" value="CAG5078970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H6J3"/>
    <dbReference type="OrthoDB" id="8825892at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043025">
        <property type="term" value="C:neuronal cell body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008046">
        <property type="term" value="F:axon guidance receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050808">
        <property type="term" value="P:synapse organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050958">
        <property type="entry name" value="Cell_Adh-Cytoskel_Orgn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45080">
        <property type="entry name" value="CONTACTIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45080:SF8">
        <property type="entry name" value="IG-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Ig-like" evidence="4">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="4">
        <location>
            <begin position="100"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="4">
        <location>
            <begin position="247"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAG5078970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="357" mass="39987" checksum="F508E135C357D430" modified="2022-05-25" version="1" fragment="single">MDCSVSLGYYNNLFLAWLTPQTTNHMSRNFNVIPSYSQDVDSGIRYASHQLTIENVTAEDFGDYECRYFKYASIETAKVTLTPHERKHLEISMSVPNARPKIEGLKKQSSYSLNEEAKFHCQARGNPVPNITWKYWDERLNLVPIEFNQITETGPKIGEVSSTVNVKINKAGSIRCTADNIHGKDILREKIVIKKPTTDFKNFDFDETLEKKPGFLQIDTEDSDSGSKNPDVKDIASGIESMNPIKPNNIDLYMLGTVNQEIITTKGSTVAMHCSASIEKFPNGIKWFNNTNLLATDGRITISDTKASQSHSSQLTIADVAKWDEGDYSCEGRMDDGFTVGNFYRLQVNASAVFSAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H6P0</accession>
    <name>A0A8J2H6P0_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Similar to Surf6: Surfeit locus protein 6 homolog (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HICCMSTLAB_LOCUS2855</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SURF6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001117">
        <property type="protein sequence ID" value="CAG5078839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H6P0"/>
    <dbReference type="OrthoDB" id="444809at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029190">
        <property type="entry name" value="Rrp14/SURF6_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007019">
        <property type="entry name" value="SURF6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14369">
        <property type="entry name" value="SURFEIT LOCUS PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14369:SF0">
        <property type="entry name" value="SURFEIT LOCUS PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04935">
        <property type="entry name" value="SURF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ribosomal RNA-processing protein 14/surfeit locus protein 6 C-terminal" evidence="5">
        <location>
            <begin position="24"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="142"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="142"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAG5078839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="224" mass="26314" checksum="B129FA0FDA1F2B2C" modified="2022-05-25" version="1">MPLTSHKLATNVKSEPGKKITYSKIKPVFNAEGHMIFSKFDFSEIGTKKHPKKFLGSKDPKKRLEELKTKKQKLQELKAAGETKKAKQLEQKDSWRAILARAAGERVLDDPELLKKTIRRKEHLKKHSAKKWEARTNKVQKDIETRQKKRQENILKRKKDKKTHKTEARAHLYFNVYYTLIPCLLLEIDPSQHSSAIPYIQHNTTHSQLLLLIKMFFIVLERRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H6Y4</accession>
    <name>A0A8J2H6Y4_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS2976</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001117">
        <property type="protein sequence ID" value="CAG5079295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H6Y4"/>
    <dbReference type="OrthoDB" id="6614360at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="109"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5079295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="234" mass="27348" checksum="6847D3077BDA7694" modified="2022-05-25" version="1">MKKTPIVTHNQTLSISFWLGSITALMIIRSTANFFYNIDKLHEVSCNLGYILPYIATSLKGLVVYRNQKAFFELINKVHGPIKKLKYSSGKYDDLTPFPMFKIIYAIKYYVLVMNIMCVLVHDPVVIGVIRWIKTQLVVLQSNFRDCNNFNTPRATFSMSSENYNIALDYKYFKTPEELREIQTFIPFAEEVRVDQDSFIKRFKLCMFHYRLSKGNVMSHSIKQRKAKEKHGKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H723</accession>
    <name>A0A8J2H723_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Similar to bbs5: Bardet-Biedl syndrome 5 protein homolog (Danio rerio)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HICCMSTLAB_LOCUS3036</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Microtubule organizing center</location>
            <location evidence="2">Centrosome</location>
            <location evidence="2">Centriolar satellite</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the BBS5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001117">
        <property type="protein sequence ID" value="CAG5079534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H723"/>
    <dbReference type="OrthoDB" id="10261999at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034464">
        <property type="term" value="C:BBSome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034451">
        <property type="term" value="C:centriolar satellite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060170">
        <property type="term" value="C:ciliary membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032266">
        <property type="term" value="F:phosphatidylinositol-3-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006606">
        <property type="entry name" value="BBL5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030804">
        <property type="entry name" value="BBS5/fem-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014003">
        <property type="entry name" value="BBS5_PH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21351:SF0">
        <property type="entry name" value="BARDET-BIEDL SYNDROME 5 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21351">
        <property type="entry name" value="BARDET-BIEDL SYNDROME PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07289">
        <property type="entry name" value="BBL5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF010072">
        <property type="entry name" value="DUF1448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00683">
        <property type="entry name" value="DM16"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0966">Cell projection</keyword>
    <keyword evidence="6" id="KW-0969">Cilium</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BBSome complex member BBS5 PH" evidence="10">
        <location>
            <begin position="14"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="domain" description="BBSome complex member BBS5 PH" evidence="10">
        <location>
            <begin position="144"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAG5079534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="328" mass="37071" checksum="D77DEAEA72DD9E16" modified="2022-05-25" version="1">MPLVQKDLQIRDGEILIDKLDMIEDTKGNAGDQGRLMVTNLRIIWHSLMLPRINLSIGYDTIINTSTKIVNVIQGMTTQALYLLTSFKNCKYEFIFTNLNTKNFRHYTSVTGVFRAYMSTKTYREIKLRGAFIQNKSLITLPSEIISSSTPGVWNLSTEQGNVGTFLVTNIRIVWFADMNHQFNVSLPYLAMESASIKSSKFGPTLVIISTKSSNGYVLGFRVDPVQKLHTLNKEIQTLKTSYDKSPIFGVEYTFEYQGVIEPEVKEEVTKEIQDSNDEISNVFGLYFADDGTKQHQPQLDSYLGLAAEEPRPGISLQSLWELIPGNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H7B6</accession>
    <name>A0A8J2H7B6_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS2795</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001117">
        <property type="protein sequence ID" value="CAG5078630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H7B6"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5078630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="91" mass="10190" checksum="9EECFF232D74A3D1" modified="2022-05-25" version="1">MYSLGGLLKLTIISMSVILYLPVPSRLRLRVFLPDGKTGTGVYREIAQYSSPWSFRPVAASSEQQPATTRFTISPVIVNCVFLSRCDNFFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H7F6</accession>
    <name>A0A8J2H7F6_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Similar to K12H4.7: Putative serine protease K12H4.7 (Caenorhabditis elegans)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HICCMSTLAB_LOCUS3269</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S28 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5081380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H7F6"/>
    <dbReference type="OrthoDB" id="1735038at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008239">
        <property type="term" value="F:dipeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070008">
        <property type="term" value="F:serine-type exopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.980:FF:000003">
        <property type="entry name" value="Serine protease 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.980">
        <property type="entry name" value="Serine carboxypeptidase S28, SKS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008758">
        <property type="entry name" value="Peptidase_S28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042269">
        <property type="entry name" value="Ser_carbopepase_S28_SKS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11010">
        <property type="entry name" value="PROTEASE S28 PRO-X CARBOXYPEPTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11010:SF117">
        <property type="entry name" value="SERINE PROTEASE 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05577">
        <property type="entry name" value="Peptidase_S28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 7" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035305913" evidence="6">
        <location>
            <begin position="19"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAG5081380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="447" mass="50899" checksum="2391C91BF02AEEBF" modified="2022-05-25" version="1">MKYLLVLCLLIFADGSSAWRRFFRGRSKDGLGTPNLSRNHKLADDLWFQQELDHFDPTNTQTWHQRYFMNKQFFKPGGPVFIMIGGEGEASAKWMAEGQWIEYAKQFRALCFQLEHRFYGKSHPTQDLSIKNLVYLTSEQALADLAYFIEGITHLHQIPAGTKFIVFGGSYPGSLAAWMRVKYPHLVHGAVSTSGPLLAKIDFQEYYAVVEDALKTHSQACVDSIAAANKQFHAMLRHRIGQQDLSKLFKLCDPLDPAATKKNDISNLYETIASNFAEVVQYNKDNRNSSKTANVTIDTICDVLVDEKQGIPIERLGAVNNLLLKANNETCLDYKYMKMIDELRNVSWKAESSEGGRQWFYQTCTEFGFFQTSTARPELFSEMFPVEFFVQQCTDVFGPRYNIHLLESSVERSTAHCANMYPASSSDLPDLVKARQKVGAIIHDWLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H7M1</accession>
    <name>A0A8J2H7M1_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS3493</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5082224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H7M1"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5082224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="100" mass="11454" checksum="DF34D110F2375400" modified="2022-05-25" version="1">MLSAEKTRCEVERRRSFGHRQQVAVKTVFNLINGCHVCGLGENRVRDTTTVNGRQSPTNPPFRSVNNRFKESEIKRKNGNKQDTVLLGTLLLIRNEFSRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H7T9</accession>
    <name>A0A8J2H7T9_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">YqaJ viral recombinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS3724</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5083074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H7T9"/>
    <dbReference type="OrthoDB" id="8192504at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd22343">
        <property type="entry name" value="PDDEXK_lambda_exonuclease-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051703">
        <property type="entry name" value="NF-kappa-B_Signaling_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011604">
        <property type="entry name" value="PDDEXK-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019080">
        <property type="entry name" value="YqaJ_viral_recombinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46609">
        <property type="entry name" value="EXONUCLEASE, PHAGE-TYPE/RECB, C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46609:SF8">
        <property type="entry name" value="YQAJ VIRAL RECOMBINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09588">
        <property type="entry name" value="YqaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="Restriction endonuclease-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YqaJ viral recombinase" evidence="1">
        <location>
            <begin position="32"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5083074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="242" mass="27743" checksum="02F0109CF16B6CEC" modified="2022-05-25" version="1">MVFINLTWNDPNIKVLSRKPVEALVSDMLNPSKIDSASTRYGLKMETHAKDKYQELTNCIVKRVGVLVSKFQPWLCASLDGVVTDDGSISKIVEFKCPSSCEKKPIINTVDNSSNIKYLQLIDNKLQLKKTDLYYTQVQVQMYVSGMSVCDFFVYSPVEDGSFLIEVHRDEDFLKTVILKSEQFYFQHYLPALYATLTIEDSDKENNYNNCDNTDNLDSNEENDITMEKLSCTESDIENIFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H7V4</accession>
    <name>A0A8J2H7V4_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS3643</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5082749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H7V4"/>
    <dbReference type="OrthoDB" id="7871514at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="282"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="109"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="109"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5082749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="318" mass="35805" checksum="D02EC4750D68EF72" modified="2022-05-25" version="1">MPNGGFHEGLEERGKGFRNLKRPIKQPNIVGWKVKSFDPEALLIALDGYPINTGCAEEQIKDLMRRVTHACDTSMPRKRGINSIPSVHWWNDHISVLRKEYSEHDALMNENPKQKTPPNKPNFNSQNSPTQKERRLRLSNFRIKPGTFLVSINVNKRIKASSSTQILSLAGKKLCEDNINLKAAILSPGLLPLLHKFAVGRDEYFASNQNLCGLSLVSLGKAAAGLQPETLPQVQPFQSIYTSPNSFREQEQGPAGLQNQFEVKVITGFEELVYYNPRPESWISWRMGVLVIILDGLDAILLAFMHARSRCLQKDSFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H7Z7</accession>
    <name>A0A8J2H7Z7_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Similar to UNC13B: Protein unc-13 homolog B (Homo sapiens)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HICCMSTLAB_LOCUS3830</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5083405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H7Z7"/>
    <dbReference type="OrthoDB" id="10053234at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031594">
        <property type="term" value="C:neuromuscular junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098831">
        <property type="term" value="C:presynaptic active zone cytoplasmic component"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042734">
        <property type="term" value="C:presynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030672">
        <property type="term" value="C:synaptic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043195">
        <property type="term" value="C:terminal bouton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019992">
        <property type="term" value="F:diacylglycerol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005543">
        <property type="term" value="F:phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017075">
        <property type="term" value="F:syntaxin-1 binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061789">
        <property type="term" value="P:dense core granule priming"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099525">
        <property type="term" value="P:presynaptic dense core vesicle exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035249">
        <property type="term" value="P:synaptic transmission, glutamatergic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016081">
        <property type="term" value="P:synaptic vesicle docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016082">
        <property type="term" value="P:synaptic vesicle priming"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04027">
        <property type="entry name" value="C2B_Munc13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.357.50:FF:000001">
        <property type="entry name" value="Protein unc-13 homolog B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000002">
        <property type="entry name" value="Protein unc-13 homolog B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000014">
        <property type="entry name" value="protein unc-13 homolog B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.20:FF:000001">
        <property type="entry name" value="Protein unc-13 homolog B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046349">
        <property type="entry name" value="C1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010439">
        <property type="entry name" value="MUN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014770">
        <property type="entry name" value="Munc13_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014772">
        <property type="entry name" value="Munc13_dom-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002219">
        <property type="entry name" value="PKC_DAG/PE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027080">
        <property type="entry name" value="Unc-13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037302">
        <property type="entry name" value="Unc-13_C2B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10480">
        <property type="entry name" value="PROTEIN UNC-13 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10480:SF12">
        <property type="entry name" value="UNC-13, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00130">
        <property type="entry name" value="C1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06292">
        <property type="entry name" value="MUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00360">
        <property type="entry name" value="C2DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00109">
        <property type="entry name" value="C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01145">
        <property type="entry name" value="DUF1041"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57889">
        <property type="entry name" value="Cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51258">
        <property type="entry name" value="MHD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51259">
        <property type="entry name" value="MHD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00479">
        <property type="entry name" value="ZF_DAG_PE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50081">
        <property type="entry name" value="ZF_DAG_PE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="9">
        <location>
            <begin position="40"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="8">
        <location>
            <begin position="177"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="MHD1" evidence="10">
        <location>
            <begin position="609"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="domain" description="MHD2" evidence="11">
        <location>
            <begin position="862"/>
            <end position="965"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="8">
        <location>
            <begin position="1031"/>
            <end position="1157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="976"/>
            <end position="1023"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="789"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="994"/>
            <end position="1005"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAG5083405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="1203" mass="137179" checksum="D7FB4CF8B9038479" modified="2022-05-25" version="1">MPRDDFAISDRVCVLMPLQKMHVYKKTLQAMIYPISSTTPHNFVTWTATSPTYCYECEGLLWGIARQGVRCMECGVKCHEKCKDLLNADCLQRAAEKSSKHGAEDKANSIITAMKERMKQRELEKPEIFELIRSVFGIDDKEHQKYLTSVKQSVLDGTSKWSAKIAITVDPDTHIDSLEQAEMIVLEGTSKWSCKIAITVISAQGLIAKDKSGTSDPYVTVQVGKVKKRTRTITQELNPTWNEKFYFECHNSSDRIKVRVWDEDNDLKSKLRQKLTRESDDFLGQTIIEVRTLSGEMDVWYNLEKRTDKSAVSGAIRLHISVEIKGEEKVAPYHVQYTCLHENLFHSLCEGNDGNVKLPQAKGDDAWKVYFEPPGEELVDEFAMRYGIESIYQAMTHFHCLSTKYLCSGVPAAMSALLANINAYYAHTTASSAVSASDRFSASNFGKEKFVKLLDQLHNTLRIDLSMFRNNFPASRPEKLQDLKSTVDLLTSITFFRMKVQELTSPPRASTVVKDCVKACLRSTYQFLFEHCYELYNREFQVDPNEAKRDPNDHGPVLDSLDFWHKLIALIVSVIEEDKNSYGPVLNQFPQELNIGQLSAATMWSLFAVDMKYALEEHEQYRRCKSSEYMNLHFRVKWLHANYVKDVPPYKGAVPEYPAWFEPFVMQWLNENDDVSLEYLHGAFNRDQKDGFIKSSEHALFSVSVVDVFTQLTQCFDVVSKLECPDPEIWKRYMKRFAKTIVKVLMSYSDIVKREFPGHLKDERIACILMNNIQQLRVQLEKMFESMGGEKLEEDAANILKELQQQLNTALDELAVLFARSLEPRITVSVRELGDLLLAIKGGGQVNLQQAAQRDAVAMEADDVLRPLMDLLDGSLSLYAQSCEKTVLKRLLKELWKIVMRILEKTVVLPPMTDKNVALDTIKQYFHAGGNGLKKNFLEKSAELQSLRYALSLYTQTTDTLIKTFVTSQLNQMPLNNATTLRQRQRSVSSDRGDDGDDDGMEGLEEPLRQSKPPPLRRESRQDTLDGGAVGELSLQVDLFTHPGTGEQKITVKVSQANDLKWNPQSFKPYVEVNLIGPHLAEKKRKYATKSKSGTSPKFNETFHFMIGNDQQLLDYLELHVCVKDYCFARPDSLVGVAVIQLKDIAEEASRPYVLSLGKRIQMDETGWTILRILSQRNNDEVAKEFVKLKSDIRQENQQPNPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H895</accession>
    <name>A0A8J2H895_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Similar to EHD1: EH domain-containing protein 1 (Bos taurus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">HICCMSTLAB_LOCUS3756</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endosome membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5083179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H895"/>
    <dbReference type="OrthoDB" id="1716625at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055038">
        <property type="term" value="C:recycling endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016197">
        <property type="term" value="P:endosomal transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09913">
        <property type="entry name" value="EHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000147">
        <property type="entry name" value="EH domain-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.268.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040990">
        <property type="entry name" value="DUF5600"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022812">
        <property type="entry name" value="Dynamin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045063">
        <property type="entry name" value="Dynamin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000261">
        <property type="entry name" value="EH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031692">
        <property type="entry name" value="EHD_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030381">
        <property type="entry name" value="G_DYNAMIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11216:SF31">
        <property type="entry name" value="AT21416P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11216">
        <property type="entry name" value="EH DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18150">
        <property type="entry name" value="DUF5600"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00350">
        <property type="entry name" value="Dynamin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12763">
        <property type="entry name" value="EH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16880">
        <property type="entry name" value="EHD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00195">
        <property type="entry name" value="DYNAMIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00027">
        <property type="entry name" value="EH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50031">
        <property type="entry name" value="EH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51718">
        <property type="entry name" value="G_DYNAMIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0967">Endosome</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dynamin-type G" evidence="13">
        <location>
            <begin position="53"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="EH" evidence="11">
        <location>
            <begin position="403"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="12">
        <location>
            <begin position="404"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="14">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CAG5083179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="452" mass="51455" checksum="D164EF66530E7CD3" modified="2022-05-25" version="1" fragment="single">MFSWLTREGNDKQDLFDSVTQGLNQIYKTKLLPLEQHYQFHDFHSPQLDDPDFHAKPMILLVGQYSTGKTTFIKYLLERDFPGIRIGPEPTTDRFIAVMYDQKEGVIPGNALVVDPSKQFRPLAKFGNAFLNRLQCSTLPSPVLKGISIVDTPGILSGEKQRVDRGYDFTGVLEWFAERVDRIILLFDAHKLDISDEFRRSIEALRGHDDKIRIVLNKADMIDHQQLMRVYGALMWSLGKVLQTPEVARSLPKNATLRKLNDLIKRARLAKVHAYIISALKKDMPSVFGKDNKKKELIKNLGNIYDQIQREHQISPGDFPDLKKMQESLVNHDFTKFNPLKPRLLEIVDKMLAEDIAKLMAMIPHEDVSTTIEPLIKGGAFEGVEDQTSPFGYKRGEGVDAGSDVDKDGQLDAEEFALAMHLINVKLDNYDLPTTLPEHLVPPSKRTWNESH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H972</accession>
    <name>A0A8J2H972_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similar to gudu: Armadillo repeat-containing protein gudu (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS4396</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5087009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H972"/>
    <dbReference type="OrthoDB" id="1683831at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000225">
        <property type="entry name" value="Armadillo"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46241">
        <property type="entry name" value="ARMADILLO REPEAT-CONTAINING PROTEIN 4 ARMC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46241:SF1">
        <property type="entry name" value="OUTER DYNEIN ARM-DOCKING COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00185">
        <property type="entry name" value="ARM"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="330"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="346"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5087009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="740" mass="82064" checksum="2FB41D0B10C2B63D" modified="2022-05-25" version="1">MSATKGISRTKKKLTTFESQKRSSIRSQNLDEKINATPRHCLIDETAEEDSSDDEPESGSDEETPFVNDETPEHASEFWQLQKLIKYIKAGNQTATTVALCLLKNFNLSNRTTQRAIREMGGLEVLVNLLETKDVKCQLGSLGVLSQMGYCSETRRYLIDLGIVSPLIDLLKHPARDVRILTAETMASIAMMRKARKQIRVRSGIALILDAMDVPDNVLRRNPDQLNDNERQHIAVAIACAKVLNSLSSSPKIKEQLRKHGVVFFMSRFLQSTHIELIIPIMGAIQQCADLKVFRLAFEQIGIISEIVRHLCDSEAASIKYKQMLVNHHKSSHTVESSSSPELDAQNEKKASEEASRGEKDRLKLEENCALAIYKCAANKLTRDMVRQSGGLDPLCRLIQSDNIRSNKNLLAAVTGAIWKCAISPENVSRFNQNSLVASLVPLLEENEDDQVLANVVGALAECCVDPANRHVLRINNGLPKLIRLLSGTYEPLLENLPLVIKECAEDEQCMDVINDPSHSLDGVRLVWSLLKHPSNVIKRNACRALVPCIKNAKDSPEMVRAFVGGLEVTVSILDSDDTQVLAAVCATIAAIAVNPENLGILTDHGVVKKLAKLVHTEDEHLRSNLTLAIAFCCEWDRNNYEFGRLNAVAPLVNYANSKNKHVLKGVCIAFYHLSKEPLNCVTMHTCGVIKHVLRLVGSDDPEVQIAAATTIRHIRKLALNTEKLNFGGINSLEEMDYCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HA21</accession>
    <name>A0A8J2HA21_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Chromo domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HICCMSTLAB_LOCUS5394</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5089837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HA21"/>
    <dbReference type="OrthoDB" id="1918685at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023780">
        <property type="entry name" value="Chromo_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023779">
        <property type="entry name" value="Chromodomain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051219">
        <property type="entry name" value="Heterochromatin_chromo-domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22812">
        <property type="entry name" value="CHROMOBOX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00385">
        <property type="entry name" value="Chromo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00598">
        <property type="entry name" value="CHROMO_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50013">
        <property type="entry name" value="CHROMO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chromo" evidence="5">
        <location>
            <begin position="226"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="134"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="321"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="556"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="607"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="704"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="757"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="798"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="852"/>
            <end position="897"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="272"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="161"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="177"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="393"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="422"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="607"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="704"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="800"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="866"/>
            <end position="897"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAG5089837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="1176" mass="127112" checksum="6F822318F99F3C5A" modified="2022-05-25" version="1">MEAGDGSTVVNNPAVIKAAQEEIGRLNVLVCGQCHLVFHFVEEFQEHQNKEGACTKTSHFRDNGNNEQKAQVWAFLLWKDTQIQQETTDKDSVTSWKLYQKWCKMEQHVRETWITAGRTIQAFTKINNAKMTDMRSHNTDGAKQPIIVRKVVRNGQPEDSSEAKKKEIKSEVKAESSESAPTTTTTTTTTTAQTKKVMQTRPKAFVKPRVRPGKTQPDDEPNDEEFAVEKIMAKRYNTKKRCAEYYLKWEGYAPEFNTWESADVVSSCKFLLEEFERNLAKQKEMKELKAQQLAQQQQQQQQQQQQQQQTKIISRTVTQKTIIKAEPSTPGPSSAAQITRPMRSSKSKAMDQVKQWCGSMKEEDNDLLGKRRADLTDSDSDTTAAKRAKGEGASDEDYTGESEEERNTTGRSDVIQRAFNRANAQSNGSNKTVSSSDLATSLGLQSPDPTKTHQSPVLVANAKGVVKVDPKQMPNLASGVYVMSKKEGIIKLDSSPAGKQIKSGTGGVLMVPNRENPTVVRRQVITASQANSITPVKVVSKPDGSQVVTQMKVISKQVPAKPRQSLGPKNEPVKIQPKPDPTQLQQIHVVTAVQNPIGMQPRITTNVRPSIQQQQQQKTADGRPLLPRPSVRGPGPTSVLGIGSIRSPVRAPTPRLQSPQTRAPMQKRVVAGSPQATMSPNQQTQLRAKYIASPNQIVKTVVSSAQLKQSPGNKLSPGNKQTQSLISPQQKTLMTKRKTQELTPQGVVKTPMKTMVNTKAPAGRGRGKITTTTPVATPGKPKETKIVASDGLHMEFQEVGSEESSDEAGPDQVTSEADNLCNIPQNPPESPERPFTLCPLTGRIIGEDGEPVAEAEPTTSHTSVDTTAASSITGTTVTATTSASESMDTSSSTTTTTTELVLPSLESLTETNSIMRVEMSPGGTTGTIVQASTDPTAQLSLAGVTIAPDLPCLDDTATTSVTSVQSTVSLTETIASDAIATTTGLTGTIVTSSASNVANVKQEIKDEERKVVADDASNVVTITGEDGVVYQVAGHAEDGQTLLVTRGADGEQQCVYVTTEQQGDEGSVLTLDHAVAEAVAQLMPDQVNLAPQFYVKEGEGEATENQMVMSIMDNSAAGAVGGQEDSEGQAQVVAQVVQADEPTPGGTRRVVLLLPDGNLMMTEVDEEQYAALELDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HB13</accession>
    <name>A0A8J2HB13_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Pre-mRNA-splicing factor SLU7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HICCMSTLAB_LOCUS4528</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Involved in pre-mRNA splicing.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Associated with the spliceosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the SLU7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5087497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HB13"/>
    <dbReference type="OrthoDB" id="249612at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030628">
        <property type="term" value="F:pre-mRNA 3'-splice site binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021715">
        <property type="entry name" value="Slu7_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039974">
        <property type="entry name" value="Splicing_factor_SLU7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12942:SF2">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR SLU7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12942">
        <property type="entry name" value="STEP II SPLICING FACTOR SLU7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11708">
        <property type="entry name" value="Slu7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 9" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6 9" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="11">
        <location>
            <begin position="52"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="76"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="131"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="374"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="77"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="142"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="382"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="410"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="420"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="434"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="455"/>
            <end position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU367071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAG5087497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="523" mass="60593" checksum="6571112082451C00" modified="2022-05-25" version="1">MGPADGTCLLRLRVRHQRPQPEKQKTLSGIDDWYRRGVDTSKVAKKWKPGSCENCGAEDHIKKDCFDRPRKVGARWNNKNIAPNSFAQPSLSTDYDGKRDRWAGYDPAEHRAIVEEYQKIEDAKREIRAEKLNTGEDDGGQDSDKDEDKYVDEVDMPGTKVDSKQRITVRNLRIREDTAKYLRNLDPNSAYYDPKTRSMRDNPYDGKSAEVDYQGENFVRFTGDTSKHANAQLFAWDAYEKGVDVHLLAEPTKLELLKQEYDKKRDELKNEVKSSIIERYGGEEHLKQPDLDLVSAQSEHYVEYSRSGKVIKGQEKQIIRSRYEEDVFMHNHTSVWGSWWSKGQWGYKCCHSYSKNSYCTGEAGIAAAAEAAQNVTAPSRSGEVDEKEEPKKKSKKQKDESSSSDSSSSSEDEEDEEEKLENTSKSERKSSAKKEKRKRHKENLKHKKKLKRALKKEEEHQREVDRLMTIDERKRPYNSMYQVKEPTAEELEAFQMKRRLEEDPMLQFNLYLLISPGAFLPYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HBP2</accession>
    <name>A0A8J2HBP2_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to CG9801: PP2C-like domain-containing protein CG9801 (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS6471</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5092952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HBP2"/>
    <dbReference type="OrthoDB" id="2556847at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053287">
        <property type="entry name" value="PP2C-like_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21586:SF0">
        <property type="entry name" value="PP2C-LIKE DOMAIN-CONTAINING PROTEIN CG9801"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21586">
        <property type="entry name" value="TIPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13672">
        <property type="entry name" value="PP2C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="2">
        <location>
            <begin position="322"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="544"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="621"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5092952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="621" mass="68046" checksum="B5401CCC8729D82A" modified="2022-05-25" version="1" fragment="single">MPSLRKKVVGFMRQLSISNLTAAVENIGHNDNTLTPRSPPADFPGGCFVTRYLNGLEEKIEGPVILHGRNPEELPIKVLEKLDDNEEVFAAFTGPDRGLTTVNLKQKHLSISDPDVDYIDILDQNDQEATVNTSMDCIFSVADNRWLLIRTNESCPIDNSTIKIRAAGKLYEPDKKYSGENNEYTFQEVDQKNSNVNFNGKKITGVKFLCEDDKKSEDFVDMATIDEGIQASSDSGDNVDNSDDDNKIDLIRVSDDTLGNITPTDVDVDDIIPPPKDFANDMIPLRKSKSAPAPFKNAQKASLSSNEMIAGIENWFLPHELAYGIATTLYEKNPTNNVTNGEPIADCFGIAARPNAAILILADGVNWGVKASLAARSAVHGSMEYLNKALFTPSNNSGVTTTKDVFVALLRSFHAAHSMILQEQGMLTTLTVCVVLPITSTDPNKHKKYVACTCNVGDSLAYVYSKKTGVREITRGSHDIYCMRDMRDALGALGPVDGCNPELNNLTLAMTEVDESDIVFLTSDGISDNFDPVVGKFAILPANSHSSNSQRPGRSDARHHTRMRSSCSDNNDLPVVEAYQRHELTLLRMEDLLSRGVSGDGPPCNSAKKLCELLLDFAVSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HBY3</accession>
    <name>A0A8J2HBY3_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS6390</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5092827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HBY3"/>
    <dbReference type="OrthoDB" id="6077994at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00821">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="2">
        <location>
            <begin position="38"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="418"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5092827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="515" mass="58704" checksum="D0C0176C145E12D7" modified="2022-05-25" version="1">MSSPQVIKIKLLQFCFIKIHLITDINMDSYAELCGFMDAKLPGNLMRKRSFVSWKTWRRHWCTVRKLGPGLGAEVQLERGLTIDGLNAYRNTIKIPSDSIICRTESRTKSYAFGIFPAKERKPFLYLSGMSESETQRWMANIRELLKPRRCRFLEGTFNISMVDNTHSRSAGLTGLHGDLVASRSGIFVKDVHNGNIIEHLEWTEMNQFNLATIGHPDDVKRICVIHTTKSFRGGIGELYIFCLNASQLLQSLVKQGREPFNKINKVEIIRPLSLSEGDLRFTNDNETGSLTIKNKVSNISNAGLLLLQPRLEREGKFMFNDTSDSGNTLRKINEDKLDYYMRAVDNVYETEPANLSNISASLEELEEPLHKRVSNLSVASGIYEEIVENHYDNKLSMDNLHLYENLSDIKLNSYNKSRIPPPLPPRTRCASDSSKNGVLSDEELCHEENSKLLTSNTPLTDINLESSQKILMPVYTTSEHSDYVPMSPRPKDFAAEQEKKQLVSHEEDIYMVMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HC38</accession>
    <name>A0A8J2HC38_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to Rasa1: Ras GTPase-activating protein 1 (Rattus norvegicus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS6749</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5093325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HC38"/>
    <dbReference type="OrthoDB" id="1562946at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.506.10">
        <property type="entry name" value="GTPase Activation - p120gap, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039360">
        <property type="entry name" value="Ras_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023152">
        <property type="entry name" value="RasGAP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001936">
        <property type="entry name" value="RasGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10194:SF146">
        <property type="entry name" value="RAS GTPASE-ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10194">
        <property type="entry name" value="RAS GTPASE-ACTIVATING PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00616">
        <property type="entry name" value="RasGAP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00323">
        <property type="entry name" value="RasGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00509">
        <property type="entry name" value="RAS_GTPASE_ACTIV_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50018">
        <property type="entry name" value="RAS_GTPASE_ACTIV_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ras-GAP" evidence="2">
        <location>
            <begin position="61"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5093325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="337" mass="38264" checksum="82C6DB8CCE62A8C0" modified="2022-05-25" version="1">MEEWYPLSGITPIGEWGALRLRIRYRHDLAMPPEEYSPLQQLLLDPELHVVRALADVCHSDRVPLASSLLKIFRYERKEADLLRSLNQAEVDKEDETPTLFRAASLTTTLMDLYMKSICTSFLKAALRDTIIKLIESKQSCELNPNKMDSPEDACSNAEFLLQVLDEVTLSIFTSPDACPKALRYICGCLQRAVVAKWPHERLVRTRVVSGFIFLRLLCPAILNPRSFNLLSESPPPAATRSLVMVAKCLQNLANLVEFGGKEPYMEVVNPFILKNKERMVVFLDQLSSVTEKPESESIEFRSKNIPDTARDLATLHHICVSHLRELQLLSKTQVNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HCI2</accession>
    <name>A0A8J2HCI2_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Similar to ZFP2: Zinc finger protein 2 homolog (Homo sapiens)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">HICCMSTLAB_LOCUS5387</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="1">May be involved in transcriptional regulation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5089820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HCI2"/>
    <dbReference type="OrthoDB" id="7666740at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000065">
        <property type="entry name" value="B-cell CLL/lymphoma 6, member B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000130">
        <property type="entry name" value="Spalt-like transcription factor 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000097">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000446">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000145">
        <property type="entry name" value="Zinc finger protein 574"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050331">
        <property type="entry name" value="Zinc_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515:SF49">
        <property type="entry name" value="GASTRULA ZINC FINGER PROTEIN XLCGF49.1-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515">
        <property type="entry name" value="PR DOMAIN ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="100"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="127"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="155"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="183"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="213"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="241"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="270"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="298"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="326"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="354"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="382"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="43"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="417"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="51"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="423"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CAG5089820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="442" mass="51789" checksum="02EE4CD5648F8D74" modified="2022-05-25" version="1">MNDNLPANKESKRIKHDNKILLCEKSEKNGSAHRDCNLDSRIDSEKIKLEEPDDDDDDSNDNDNPENLENVACIPEFIKKQIANANFSTEISSSDITLPYTCKICSMRFLVKAHLTAHKKIHPEKPYGCKICSLRFFQKCHLRSHMTIHEEERQHSCEVCSMRFHRKATLIKHMLIHSDEKKFSCQVCPSSFRHRYSLSVHMKSSHGQVSGPYTCEVCSTEFDKKNKYFEHKRIHIGEVRYACQDCPATYSVKKSLVRHMMVAHTGEKRYLCEFCSNRFTSSTLLNRHRLCHTGEKPFSCNICSKKFRRKDGLNGHMLMHTGKNFWTCPICSHTFRERASLYRHKKIHTGEMPFSCQICLKKFRQKHHLTLHMFAHTGEKPFNCDICDRDFREKGTLRKHIIKRHGKEIKKELETTRVETKTKTKTKTKNVKNVRKKKPTEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HDX3</accession>
    <name>A0A8J2HDX3_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Similar to FPV218: Putative ankyrin repeat protein FPV218 (Fowlpox virus (Strain NVSL))</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HICCMSTLAB_LOCUS6537</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5093036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HDX3"/>
    <dbReference type="OrthoDB" id="5806726at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="64"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="156"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="192"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="641"/>
            <end position="673"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG5093036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="739" mass="85272" checksum="59C5A8F8E0E165B5" modified="2022-05-25" version="1">MDNLREQIKELKIFREMSYEEVRDSIMSNELNVNSVVKIYDSDRMKIPISSEFLPRSGPKNNFFEYTILHLALYVDDVEFIDFLLENNADMKLETEDLAPVILSAIRLNRLKDVKKIVSAGADVNQSICVKNTDEKYSDRLINTDGGNNNAHIFYEVYSPLEFAINLNAYEIAEFLISQGANVHGRDYDEEFEDSPMSIAASSNNVEMIKLLMKHGVDINARDINGLTPLMKAALEDVSSASLRFLLSQPFIKINSLTNDQSSCLHFPEPWYMEEDIVDPESNLQDLLDAGCDINIVSNHGELPIDTYEDKEKCLEVMKKHIVKLMAAGFYVCARNKEAVSESELRNFRVECDTEVEVMKNTYGIMVGFSLFDILHRSYHKLALRIKDGDEDKFDYKMAAQFPLYAGMIKYRLEKAGQRRKLFKQVENILYKVFSRYLPATFIHEMFFYFSNFELSKLVENKLPPEKQCRHKAGNKEMCFEIMKKHIVKLMAAGFYVCDRNKKFVSGSELRKFRVECDTEVEVMKNTYGIMAGFSLYDILHRSYHKLALRIKDGDEDKFDDKMAAKFPLYAGMIKYRLEKAGQRRKLFNQVENILYKVFSKYLPATFIREMFFYFSNFELSKLSEINSEFLPLTDPEKYFFEYTILHLALYVDDSDFVDFLLKNNADTKLETEHLAAVILSAISVNSLKYVKKLVTAGVDVNQIICLDAYKIAEFLISQGANVHRRIGNDGENTDSPIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HDY3</accession>
    <name>A0A8J2HDY3_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Similar to TRRAP: Transformation/transcription domain-associated protein (Homo sapiens)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HICCMSTLAB_LOCUS6459</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PI3/PI4-kinase family. TRA1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5092940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5570127at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035267">
        <property type="term" value="C:NuA4 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05163">
        <property type="entry name" value="PIKK_TRRAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1070.11">
        <property type="entry name" value="Phosphatidylinositol 3-/4-kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050517">
        <property type="entry name" value="DDR_Repair_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003152">
        <property type="entry name" value="FATC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000403">
        <property type="entry name" value="PI3/4_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036940">
        <property type="entry name" value="PI3/4_kinase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003151">
        <property type="entry name" value="PIK-rel_kinase_FAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014009">
        <property type="entry name" value="PIK_FAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046807">
        <property type="entry name" value="Tra1_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046805">
        <property type="entry name" value="Tra1_ring"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11139">
        <property type="entry name" value="ATAXIA TELANGIECTASIA MUTATED ATM -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11139:SF1">
        <property type="entry name" value="TRANSFORMATION_TRANSCRIPTION DOMAIN-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02259">
        <property type="entry name" value="FAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02260">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00454">
        <property type="entry name" value="PI3_PI4_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20175">
        <property type="entry name" value="Tra1_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20206">
        <property type="entry name" value="Tra1_ring"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01343">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00146">
        <property type="entry name" value="PI3Kc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51189">
        <property type="entry name" value="FAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51190">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50290">
        <property type="entry name" value="PI3_4_KINASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAT" evidence="4">
        <location>
            <begin position="2848"/>
            <end position="3427"/>
        </location>
    </feature>
    <feature type="domain" description="PI3K/PI4K catalytic" evidence="3">
        <location>
            <begin position="3682"/>
            <end position="4008"/>
        </location>
    </feature>
    <feature type="domain" description="FATC" evidence="5">
        <location>
            <begin position="4011"/>
            <end position="4046"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="508"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="3140"/>
            <end position="3169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="3439"/>
            <end position="3470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="3442"/>
            <end position="3463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAG5092940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="4046" mass="458691" checksum="A6CF647762BC954B" modified="2022-05-25" version="1">MPPPQPPPPDPVTQMNTYRSYVTMLADPNSKDELKLKAAQELSENFEVIMCSSQYPAFLDHMMKIFVKILQEGEPHFISEYNIQQVRKLILEMIHRLPTNEHLRPYVKPILSLMLKLLETENEENILVCLRIIIELHKQYRPTFNPEIQHFLQFVKSIYSELPKNLNKIFEPRPPIKVKDLSELNIESLLRETFTITPVQSEKKATDGTIITYNLIPKAVLSLKVLQELPIIVVLMYQIYKQNVHQDVADFIPLIMTTITLQPSLQHRNAPGFNKEVFVDFMGAQIKTISFLAYIIRIYQDVVATHSTMMVKGMLGLLTLCPIEVTHLRRELLIAARHILATDLRIKFVPYMERLFDEQVLLGNGWTTYESLRPLAYSTLADLVHHVRQLLFLPDLARAVHLFSKNVHDQSLPTSIQTMSCKLLLNLVECIRTRSDSDNSNQGRELLMRMLEVFVLKFKTITKLQLPILLNKANNAKAIAAAATGSGVVAGSTPGTSATGATVEIKTEDNKPPLLQETEQEKEASKSKFLTPQNQASSLVNCNVSDYRSLIKTLVCGVKTITWGCANCKSTNSAGDVIQSKQFQPRETLVFIRLVKWALQALDIYTIGPLMTNPTLSTQQHQYHIRAGAQAQPPPPQTVRTKEEKEVLEHFSGVFSMMNPQTFQEIFSTTIDYMVERIFRNGALQIVGNSFLANPTTSPIFATVLVEYLLERMDDMGSNVERSNLYLRLFKLVFGSVSLFPAENEHMLRPHLHQIVTRSMELAMSAKEPYNYFLLLRALFRSIGGGSHDLLYQEFLPLLPNLLEGLNRLQSGLHKQHMKDLFVELCLTVPVRLSSLLPYLPMLMDPLVSALNGSHNLVSQGLRTLELCVDNLQPDFLYEHIQPVRADLMQALWRTLRNPNDQVAHVAFRVLGKFGGGNRKMMIEPQRLDYNDRDGVNGNESPAIIIHFPDSPTSPVKLPIEMIIETAFTALKSNTTDSFYRKQCWQVINCYLASVLQLNPDTTTDSTDATDEATRLALNKLFTSPSFKENNLPSLQQQQQSQLQEINYKYENMVARNVLQTALTGLFVAAAIKELKQSVIATMVSLVRHYTIIAIAQQAGPYCLTADKQPNGYINRCQDPLVLIDALATIMGHEEKELCKPGQLALILTLETATQILGSKERACQLPMMEYLAEKMCALCYERAWYSKLGGCIAIKFLFERMATKWVLQHLFQFLKALMYVMMDLTGKVSNGAIDMAKENLEQMLRVYVHPDIITATPELLDVQNKSIHDVTHELVRQVTSPHTLVREQAMSSLRLLAEIQNKSVTQVMEPHKDVLADMIPPKKHLLRHQPANAQIGLMDGNTFCTTLTPRLFTIDLNIPEHKVFFHELQALCDHEDSILHKLPCYKSVSNLIPLRKSALRALAACHYIVCLREKIFKTLYHTFERPNPELQQAAFECMQKFIGGFQMDMETVHTTMRPMLLMLGDHRNLSLNCVKRLSYLTQLFPSTFSITLCEQLLLHLKKLLENLIQTNQTTQQHKTTANNIKFDDDCKEKISLIIGIFHLIPAATPKFIDVLCRLVLQTEKSLLIEASSPFRRPLMKFLLRYPTETLTLFLHDNNIKDQQWSRYLEYLIKQSVDGKAFRDVLYTNTNCTGRLITMLLAATASNSSLSTTLTTSATSANLTAADKYELQHQAIRIISVLIKYDEQWLSSQGQIVAALKQLWYQDGYLDLHKRVENVDFSRWKEPKLVVKILLHYFSHHPTDIDLLFQLLRATCDRFIPDFQFLRDFLENTVAKEYGVEWKRSAFFRFVEHCPEVMTLSTGVPSTASTLSEELRAKILQLIIIPAFAISFERGEGVKLVGGAPMPYQDNPENVVSVFITRVIDPEHPFVSADCLRISLLQFSCLLVEQASQHIHDVTNKRQGNKLRRLMTFAWPCLLGKNCVDPATRYHGHLLLSHIIAKFAIHKRIVLQVFHSLLKAHAVEARSVVRQALEILTPAMPVRMEDGNTMLTHWTKKIIVEEGHSMQQLIHILQLVVRHYKVYYPVRHHLVQHMVNSIQRLGFSPNATLDNRRLAVELAEVIIKWELHRIKDEAAGQPMDTSDPNLTLNELMANPVNRFPGEPSATKPIERGHADSILNFLLRLACQVNDGTSGMVTAAGAAGAAGSATSTATPAATAAAIQSSGNPGELLSRRCVNLLKMALKPDVWPSSTQQQQPPPDLKLNWLDKVFASIDSAQPNYGNICTALELLTFLLGVMKREQILANFKLLQRGLSACLTSNNTKVIRLMHALMSRLMSIFPTESIVASGVATPASKYDELNTLYTAVTNFITEGLTAYEKNTGLLSSTTGTPASSISTSLFGTLMILKAACINNPSYIDRFIAQFGRVLHRMTKDHLQLSSTGVNSESTTSTTLADSNPVNSELLILSLDLVKNRVAVMSPDMRKSFISSILIILIEKTHDIKIMKAITRMLEEWMKNKNPIAVNQAPSLKEKSMLLVKMMQCVEKKFPDDQELNGQFLELVNYVYRDETLRTTDLTSKLEPAFLSGLRCTQPQIRAKFFEVFDSSMRRRLYDRLLYIICSQSWDAMGPHYWIKQCIELVIVTASASTPMKLSNQDNLLPSLSSIINTSRFASTSLISNDEADLFFTRIKKEPGLDEEMTDDFVGNLDSLVSIVKDDLMDMDLGTISADISMEIDKKPVIETTETINQLIIKQDEFLQTARKVKTEQFLLAAAQLCHMDTNLAERVWLDIFPRLWGILDETQHAALTAEIVPFVCSGAHVIQKDCHPSAIATFVEAISHCDPPVPIRPPLIKYLGRSHNLWHRMTLTLEKMAFENGDFNNGSDSGVGVNNNANVNANSSSLFSDKRDMIPTQSAFDCYDFEPADAVTAANNPHAQILDSLADMYALLCEEDMWCGLWQKHAHYKETVQATALEQQGFFEQAQVAYDQAMTKFKQDYISSPAPFKIQRETLLWEQHWIRCAKELNQWDLLLEYGGKKAERNPFLVLESSWRVPEWAQMKEALAQVEHNCPKEMAWRVNLYRGFLAICHNEDQHLNTVERYVEMASSLCMREWRRLPPIVSHIHLPLLQAAQQIMELQEAMQIHQGLLHGRSTASSLHDMKAIVKTWRNRLPVIADDLSHWSDIFTWRQHHYTFISSHYDAQQQQQQQQQQQQQQQQQQQQQDPANPQAAAAVTPTVTTNNHSMLGVHASAQAIIHFGKIARKHNLTGVCLDSLSRIYTIPSVPIVDCFQKIRQQVKCYLQMAAVSGNNELQEGLEVIESTNLKYFTKEMTAEFYALKGMLLSQIGRSDDANKAFSAAVQLHDTLVKAWALWGDYLEQIFTRDSRQQIAIGVSAITCFLHACRHQNESKSRKYLAKVLWLLTYDDEKNLLMDAVEKYAVGVPPIQWLPWIPQLLMCLIRHDGLVILNLLSQVGRMFPQAVYFSIRTLYLTLKIEQRERYKSAELQQQQSGTSSNMSSNQSNSSTSTETGPIRATPPMWRCSKIMHLQRDIHPTILSSLEGIVDQMVWFRETWYEEVLRQLRQGLAKCYAIAFENRGAVSEATITPHTLNFVKKLVATFGIGIENISSTSSQATPQTFGSAASESLARRAQATEKDPVFKSMKGKFSSDFDFTEPGAKLLHNLISKLKKWIKILEGKTRQLPKSFLIEEKCRFLSNFSLKTAEVELPGEFLLPKHSHYYVRIARFMPRVEVVQRHNTAARRLRIRGHNGRLYPYLVVNDAGLGDARREERVLQLLRMLNYYLAKQKETSRRFLHFTVPRVVAVSPQMRLVEDNPASTSLLDIYKLGCAKINNGSNEGMEHDAPIARYYEKLAVMQAKGAQASHQMLRDILKNIQSTMVPRTMMKSWAVKTFPVATDYWTFRKMFTLQLALACFAEYVLHLTRLNPDMMYIHQDSGLVNIAYFKFDVDDMSGELDAQRPVPFRLTPNILDFITTTGVSGPLTASAIAIARCLVHPSFKVHTILRAILRDEVIADHNRKQEDIENASQAPADMKGELLITMVTRAVTAIMTRLNSLANFADNGEGNKVTTLVAAASSHDNLCRMDPSWHPWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HE28</accession>
    <name>A0A8J2HE28_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">receptor protein serine/threonine kinase</fullName>
            <ecNumber evidence="3">2.7.11.30</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">HICCMSTLAB_LOCUS5964</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.30" evidence="3"/>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5092180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HE28"/>
    <dbReference type="OrthoDB" id="69842at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004675">
        <property type="term" value="F:transmembrane receptor protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071363">
        <property type="term" value="P:cellular response to growth factor stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23596">
        <property type="entry name" value="TFP_LU_ECD_Tkv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000304">
        <property type="entry name" value="Receptor protein serine/threonine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.60.10:FF:000021">
        <property type="entry name" value="Receptor protein serine/threonine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000055">
        <property type="entry name" value="Receptor protein serine/threonine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.60.10">
        <property type="entry name" value="CD59"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000472">
        <property type="entry name" value="Activin_recp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003605">
        <property type="entry name" value="GS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045860">
        <property type="entry name" value="Snake_toxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000333">
        <property type="entry name" value="TGFB_receptor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23255:SF106">
        <property type="entry name" value="RECEPTOR PROTEIN SERINE_THREONINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23255">
        <property type="entry name" value="TRANSFORMING GROWTH FACTOR-BETA RECEPTOR TYPE I AND II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01064">
        <property type="entry name" value="Activin_recp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08515">
        <property type="entry name" value="TGF_beta_GS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00467">
        <property type="entry name" value="GS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57302">
        <property type="entry name" value="Snake toxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51256">
        <property type="entry name" value="GS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 14 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="12 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 14 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13 19" id="KW-0675">Receptor</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 15" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="145"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="GS" evidence="18">
        <location>
            <begin position="184"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="17">
        <location>
            <begin position="212"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="239"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="CAG5092180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="477" mass="52940" checksum="F4679DCDE98F0214" modified="2022-05-25" version="1">MAAALSVSSGKRECKYGLLWLVIAVFIAKNTGVYGIDCYCDGYCSGDQQNGTCRLSPGSFCFSSVDEVWDAELKEYVPEYSFGCLSRDDESAFLQCKGSSIPRLKTKTVICCNDTDLCNRDVFPEYIAPSTSAPETMSENSSLPLMFIAAALSVCCVAILITVVILYRKFGRRERDPCLVSSQGTLKDLIEQSSGSGSGLPLLVQRTIAKQLALSQCVGKGRFGEVWLARWRGEKVAVKVFFTLEEASWFRETEIYQTVLMRHDNILGFIAADIKGTGTWTQMLLITDYHERGSLHDYLQTSVLDHSTLFTICLSIASGIAHLHTEIFGTRGKPAIAHRDVKSRNILVKRNGECVIADFGLAVRFLSETGEIDIAPNTRVGTRRYMAPEVLDESLNTSSFDAFKMADMYSVGLVLWEVCRRCVSGGKVTTAEPYALPYHDVVPSDPNFEDMRLAICVKRLRPVIPTRWELDPVSSLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HED1</accession>
    <name>A0A8J2HED1_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Cc_bv8.4_28.11_pseudo</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS6160</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5092482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HED1"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5092482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="58" mass="6616" checksum="82358C5FAB2AF3A9" modified="2022-05-25" version="1">MEKSLIYVELTEGVYVPSRWPLSNIKMLVIALARKIIKENQNVFSILRINGISAKLIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HF69</accession>
    <name>A0A8J2HF69_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Similar to SEMA-1A: Semaphorin-1A (Schistocerca americana)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HICCMSTLAB_LOCUS7339</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5094013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HF69"/>
    <dbReference type="OrthoDB" id="9988752at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045499">
        <property type="term" value="F:chemorepellent activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030215">
        <property type="term" value="F:semaphorin receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007411">
        <property type="term" value="P:axon guidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030335">
        <property type="term" value="P:positive regulation of cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071526">
        <property type="term" value="P:semaphorin-plexin signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1680.10">
        <property type="entry name" value="ligand-binding face of the semaphorins, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002165">
        <property type="entry name" value="Plexin_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016201">
        <property type="entry name" value="PSI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001627">
        <property type="entry name" value="Semap_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036352">
        <property type="entry name" value="Semap_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027231">
        <property type="entry name" value="Semaphorin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11036:SF131">
        <property type="entry name" value="MIP07328P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11036">
        <property type="entry name" value="SEMAPHORIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01437">
        <property type="entry name" value="PSI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01403">
        <property type="entry name" value="Sema"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00423">
        <property type="entry name" value="PSI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00630">
        <property type="entry name" value="Sema"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103575">
        <property type="entry name" value="Plexin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101912">
        <property type="entry name" value="Sema domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51004">
        <property type="entry name" value="SEMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0221">Differentiation</keyword>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0524">Neurogenesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sema" evidence="9">
        <location>
            <begin position="1"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="590"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="666"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="749"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="596"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="674"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="689"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="764"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="791"/>
            <end position="806"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAG5094013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="960" mass="106620" checksum="C1F5F53D9F960668" modified="2022-05-25" version="1">MCNLKGASEDDCQNYVRVFGRQGPNKFIACGTNAYKPQCKQFVRTNGSYVGSGESDGLGLCPYDPQHNSTAVFAGGQLYAATVADFSGGEPLIHRQKIRTERSDLNQLNGPNFVSSFAYGDYVFFFYRETAVEYMNCGKAVYSRVARVCQHDKGGPHAFSDRWTTFLKARLNCSVPGEYPFYFNEIQSMSDPTTGFYAGRHDQLIYGIFTTPVNSISGSAVCAFSMSSVFDVFQGAFKEQETINSNWLRVLPEKVPEPRPGACVNDSRTLPDITVNFVKTHPLMDDAVQSFFTLPVLTKVSFNYRFTRVAVDPQVKALDGRTYDILYIGTDKFRLFLFNLFSLDLHFHFLPPHHHDINIYLIADDGRVIKALNTKAPDSLAEVGQVIVSDVQVLRYGQAIKDLQVVHLAGEASKLVVIADSEIRAVPLHHCDSPAAVNSCVACVALQDPHCAWDATMDLCVAVPTKLHDNDASKTLFQDIITGKHKGCGAQQVNVDLDLAKPVPPVMPPRIGIGEQPDERDNEIVIELDRENQYSRTQPRANEPQGVTVTPVVYSAQTLTGALIGTCFFSLIAGFASGFWFSQRLRGAPYPDPPEQRQQLNRLTESSESPAGFNNKSINLVLNVTPKNPNGKNANSSAENKPMQKAATESENSYNNEHEHYDYECYDSASESKPPSSITTPIPRRNSLPPASTVSCTSSEADLRHVSGSHHQSFEPPSYDLIVNPEFLAERSSNHEDNLERSARIYSDTAAKSTRASTPVPRSKFTESLDHLDTTSGSLSYQRRRRGHPHQKLDQSKFKEGSREHYMVPTHEPNRPTSDSRTLSLFNPEFLPNFNDMLMYVARPELSDLSQVSFPWKHHSSQVEVGGIPYDDNNPEQTIPVDPSRGFGAGTPERESSYASLNTLQDRLNHVTGILESKIKLEGKDKNLYGTLSKRQQLLESATKPAAVIKKGCNTIEYNC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HFG1</accession>
    <name>A0A8J2HFG1_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS6618</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5093142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HFG1"/>
    <dbReference type="OrthoDB" id="8193468at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5093142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="739" mass="84827" checksum="9C479CB0022BC998" modified="2022-05-25" version="1">MPVPCLFMSEVLNTLRPEQACPCLIRSVHAVKKVFQIVGDFEIADEDKVIISEVIYPFYHPKTLIVLPITSTVIPLQVYYDSKTRSGRIEWRLKTLNQSQKKGKESGKVNKDKQVQEQENIVLLDQETQSIVLEDVSIEDVTEIITFLKNAHPVKDRKNIENAMKNTFLFRRENTNNLLDEFPRFIDTPGLIILEFSWIHPGIEITDFNPQLILNVSEKYLKTIKKKESSEIDWDNTTLAYLTLLKLLPTTAKGRKKISEPNPVDNLIKFIKTGTIRQDFNIKTTHPCLVAVGVDKSNINSYFIAVDGKLLFLDEVTSAEAFDALFKSYFVLNIVFEKTLTVFFNFIQNYFYKLDGSMKFNIRMKEVRTWLTQMSQNNNMIPLFKKVKISDQNIMPSSYTEIFAQSLESSNIPKNKINQIMEKTEVMVENISKNVLKIVEKDFQVALFNSVDLQNDTDIDSFNKYLKPIVDEIKILETTGIEIGGQIFKGSLAAMSFDNLGANTIYGMVQSFSATNFCRFCFATKTQTKTMICEDPSLIRTSRNCIINKDCNGEAVLPSGVKYECQLNELKYFNIFDCPGVDLMHDILEGVAPRDVKLFLKWLVGNTRITIETINDRLIAFNYGKNEMTNKPRPMNLDKPGCLLGERASQMWCLVRYLPFLISDYIEDELVQPKWALIKKLLQIMHIVFSPVISHVCDSDRSEQRAGLITRSRVRTQRTPGIFHQLKSFLITTSYSESH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HFG8</accession>
    <name>A0A8J2HFG8_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Similar to HOMER2: Homer protein homolog 2 (Homo sapiens)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HICCMSTLAB_LOCUS6875</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5093485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HFG8"/>
    <dbReference type="OrthoDB" id="9983798at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035256">
        <property type="term" value="F:G protein-coupled glutamate receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045027">
        <property type="entry name" value="Homer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000697">
        <property type="entry name" value="WH1/EVH1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10918">
        <property type="entry name" value="HOMER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00568">
        <property type="entry name" value="WH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50229">
        <property type="entry name" value="WH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WH1" evidence="3">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="50"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="147"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="184"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="55"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="71"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="94"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="156"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG5093485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="355" mass="39334" checksum="804304BA84945800" modified="2022-05-25" version="1">MTFTKTSQKFGQWSDVRANTVYGLGFSSEAELGKFIEKFHEVKEATKVAGAKLQSNSSSVTPSTSANVSPITQRSCMPSSEQDLIDPPNSSMINSNTSASNNPNPNTSMISAQNSASSVSSSPLPGNCQSKVDEELKNAIHARSQQIALAQQQSIESPQHQGKSGQLSSNQVNQSSELQLKYENDRLKLALAQSSANAKKWEVELAMLKTNNTRLTSALQESTANVDEWKRQLQMYKEENARIKARYTDLENGKISEGNSEALKLRVEALENELRTRNDELKAMTMTAKNKDFISLQKENNELRHTLSVVHEQLELALSSNKVQKQNLETLNSRLAGYIQDLATVHREITNTLQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HGM7</accession>
    <name>A0A8J2HGM7_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to slc16a10: Monocarboxylate transporter 10 (Danio rerio)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS7269</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5093943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HGM7"/>
    <dbReference type="OrthoDB" id="6499973at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF251">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="395"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="437"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="465"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="491"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="526"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="554"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="621"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="653"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="688"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="712"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="751"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="778"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="146"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="235"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="830"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="238"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="830"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="987"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5093943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="987" mass="109751" checksum="BA72090582193F7A" modified="2022-05-25" version="1" fragment="single">MIMNRTSVEYSNSRCSNNKIARAIPKNVLVVEAQIDSAARPYGDEHVGRITKTGATTETISNNLPVFFGRGNWNIIKRPIKSTKEQDKSKGKGKDKDKGKDKAKANAKDTCRPSDNIKASVRPKTSLQYSQNLDEIIEVLTDEEDGDFEENDSTDCLGKSTPTFSSRHHRQNNGIVSFDKERSTYMTEYQCNDKNNTGEKDVCEFEPAGDTWESLSSRKSLRGKKSSWKVKPLREATRCSSSSTSSCSNNPRPSGGNQLTSIVGQRDNVYLDNINTSRSEAQRLRSCDNCRQPYYSPEDRICYKYSKINSPVSSPNTNYNEENNYELFEDRQDLPALLTYRSRSLPQLSVHDSGLGHDSGLGQDNGPGKFNNSKLVTDLRQLLTLRQHYYPESGWGWVIILVGVFVQVLSHGIHGAVGLFIHHAANRFAVQAYLDAGWLGAMSTGVALLISPVTIGFCRRKSTRVTAVLGGLVTALGCLFTSFATQFHQLFFSYGAVVGVGVGITRDCSTLMVAQYFKRKREFVEIFIVSGSGLGIAIMSAFIKSIIGKIGWRLGLQAVTVTVFSTFFLGTFYRSASLYHPQRRAILHLKNQKRKIKEKNKVDDRPPILDFSTLKSKTVRILLLSTGISAFGINTPIFYLAHQIEEEGLGDTVILLQAYLGLGWTVGCITFGLLVIRQNVECRIARQYLVQTAVFICGICILALTIVQGNYYGYVIFTWIYGIFCGGYHYSLKMYTYERVRARNFVRTWGFVQCSQAIPIAIGVPISGYINISFGNKAGYYFSSTCVLVGSFTLFFIDLHKRNLSKHRSGKTNGIKHTCNSNCPKKRGLSFNQEPENDNTPGAGAVGFNTSSEHPPALGESINKISVDKPELTCISEEGIADMDLPDNILDDIEYIGDCITSCNKVENYLMLSEFENNLIAEMPIIMDRKGRKWSLARSKSIKANQSAAGPSTSQSILDEDDVKSKWLLMPAPINNRAITVIEEAST</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HGS6</accession>
    <name>A0A8J2HGS6_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to FAAH2: Fatty-acid amide hydrolase 2 (Homo sapiens)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS8431</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5096879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HGS6"/>
    <dbReference type="OrthoDB" id="6428749at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052739">
        <property type="entry name" value="FAAH2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43372">
        <property type="entry name" value="FATTY-ACID AMIDE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43372:SF4">
        <property type="entry name" value="FATTY-ACID AMIDE HYDROLASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidase" evidence="2">
        <location>
            <begin position="99"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="1">
        <location>
            <position position="161"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="1">
        <location>
            <position position="236"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-ester intermediate" evidence="1">
        <location>
            <position position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR001221-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5096879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="556" mass="62526" checksum="FCB59DFCD1C61433" modified="2022-05-25" version="1">MPYNNNSMNIYYSNKNFIFNSKKKQVYIMNKNFIKYYGKIFFVIHRIIEFFGRWIFLLAARFSGEPETLPPIDDGIVLMRSAKALSIMILLKKINSETVVQACIDRIKKIQPVLNCVVENRFTEALNEARECDRILKFADPSILDLLKKEKPLFGVPFTTKDCIGIKDMKQTAGLYSRRNIQAEKDADVIQLLRQAGAIPIATTNVSELAMWWESANCIYGKTNNPYHTWHIVGGSSGGEGCLQAAAGAPFGIGSDIGGSIRMPCFFNGIFGHKPSRGIVSNVGQYPSPHTEKQNQLLAIGPMCRYATDLKHILKVIAGDNVSKLNLDATVDISKLKFYYMEDDGGQLFVSPVSQDIKQKINKVIWYLKTGYKIKAEKVVIKKFKNSLAIWLANMVSPVGEDFAHELSNRQGRITIWWEFIKWMMCSSCHTFIALITAAFESFGMKRDDEKRAKLLTQTLELRDEFHNMLGSDGVFLYPTHPTPAPLHHETILKPFNFSYTAIINCLGLPATACPLGFSNGLPIGIQVVAGLNQDHLSIAVAEELERIFGGWEKPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HGV7</accession>
    <name>A0A8J2HGV7_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Similar to Cwf19l1: CWF19-like protein 1 (Mus musculus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HICCMSTLAB_LOCUS9792</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CWF19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5100719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HGV7"/>
    <dbReference type="OrthoDB" id="444325at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061632">
        <property type="term" value="F:RNA lariat debranching enzyme activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07380">
        <property type="entry name" value="MPP_CWF19_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040194">
        <property type="entry name" value="Cwf19-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006768">
        <property type="entry name" value="Cwf19-like_C_dom-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006767">
        <property type="entry name" value="Cwf19-like_C_dom-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12072">
        <property type="entry name" value="CWF19, CELL CYCLE CONTROL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12072:SF4">
        <property type="entry name" value="CWF19-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04677">
        <property type="entry name" value="CwfJ_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04676">
        <property type="entry name" value="CwfJ_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cwf19-like C-terminal" evidence="3">
        <location>
            <begin position="306"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="domain" description="Cwf19-like protein C-terminal" evidence="2">
        <location>
            <begin position="435"/>
            <end position="516"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG5100719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="520" mass="59752" checksum="C987BED61C4E84A2" modified="2022-05-25" version="1">MSEKRKILVCGDVQGNLRLLFSKVEKIKKKSGPFDLLFCIGNFFGENNSQLEEYKSAKAKIPIKTFIIGPNRTSDLGHYLNLESSEICPDLIYLGKRGLYITDSGLKVAYVSGIDEPESTLPKEILLTENDVTSVRNTCLKNQPNFRGVDILLSSQWPIDVNRLDSTNQKLHFRGSKLIAWLAAQIKPRYHVCALEESFYEPPPYRNKSINGENIEIATRFVALAHITNTEKKKWIYALNLIPIDRMRLVDLATKTTDEKPFPYPTWTLNSDCFNSDSDMEPRQYFYGLKPNENKRSSENSKGTKKMKIEFDQAKCWFCLSSPQIDKHLIVSIGDQVYVALAKGGLVDDHLLILPVSHHQSLVALPEKIEKEINKTKDLLTRYYSYIGKVPVFFERNYKSSHCQLQVIPVNKNLEPYVKSTFQEIAKIENIQFSTINSSLKEVTSPGETYFYVQLPSGEQLFHKIAKNFPLQFGRQVLASRKILNLNDRIDWKTCQMNKDKEIKIVTEIRKNIQTYQLDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HH30</accession>
    <name>A0A8J2HH30_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Similar to Sting1: Stimulator of interferon genes protein (Mus musculus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HICCMSTLAB_LOCUS7528</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5095076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HH30"/>
    <dbReference type="OrthoDB" id="6053839at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005776">
        <property type="term" value="C:autophagosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061507">
        <property type="term" value="F:2',3'-cyclic GMP-AMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035438">
        <property type="term" value="F:cyclic-di-GMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002218">
        <property type="term" value="P:activation of innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045087">
        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016239">
        <property type="term" value="P:positive regulation of macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032481">
        <property type="term" value="P:positive regulation of type I interferon production"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061709">
        <property type="term" value="P:reticulophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12100">
        <property type="entry name" value="Stimulator of interferon genes protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029158">
        <property type="entry name" value="STING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038623">
        <property type="entry name" value="STING_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055432">
        <property type="entry name" value="STING_LBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055434">
        <property type="entry name" value="STING_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34339">
        <property type="entry name" value="STIMULATOR OF INTERFERON GENES PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34339:SF1">
        <property type="entry name" value="STIMULATOR OF INTERFERON GENES PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15009">
        <property type="entry name" value="STING_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23417">
        <property type="entry name" value="STING_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="26"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="59"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="99"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="143"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="STING transmembrane" evidence="7">
        <location>
            <begin position="60"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="STING ligand-binding" evidence="6">
        <location>
            <begin position="175"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF15009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF23417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG5095076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="348" mass="40016" checksum="59B15634C462CF06" modified="2022-05-25" version="1">MEEKKNDTNEKQENVLTYPHQPSMTVYILLTTAVSIIIIGVSVRLIYKDSYLKAFMDNLTTFVVCFIMLTLGSLMLRMISFLAELEYLKTYHDNQVKKIFTNTFEFNITSIVFSVFCCLYILMFAIRKGDILSYTRALDSTSNILMILLSIIVSQSIGLFRCKLNSIYTSSADEGMEVYESNQSTSDVQITIPVKKLFILIPESGHIPPDLKDASNYWLESTTSLENEVRDRAGVKKRIYRNTVYKIHPGGEGNKRKPVYIVVEGATPVLTFYEVLQHAHKHTDTYKNYQHQIIAAFYKTLQDLLNENAESRDTCELVYFKDYDDDGKRVNIGEILLERIRKEAPNCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HHS8</accession>
    <name>A0A8J2HHS8_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similar to MCM9: DNA helicase MCM9 (Gallus gallus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS10595</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5101693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HHS8"/>
    <dbReference type="OrthoDB" id="271325at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058768">
        <property type="entry name" value="MCM9_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26066">
        <property type="entry name" value="MCM9_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MCM9 N-terminal" evidence="1">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF26066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5101693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="145" mass="16866" checksum="1658E44933220A8D" modified="2022-05-25" version="1">MLKDYLIKNNYSDLLEILKAPDVSRHYSIYVNVAKLYVDDLEMVEKITKRPKKFLPLCDQSAIAAQKVIMNDDEIPQEELRLKRKVHIRITGAPWKINDETDGQLVSITGITVRISQPTMLTKCKRYSCKKCSYVTTYQVICLYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HHT0</accession>
    <name>A0A8J2HHT0_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS7963</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5095948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HHT0"/>
    <dbReference type="OrthoDB" id="66726at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="105"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5095948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="264" mass="29419" checksum="4F0572D6D7418A5D" modified="2022-05-25" version="1">MAKEAAKTRELNRTAQILRERLESGGCDLRDFLQIIGYSRPNIQAFINPALDRPLYRFDPFSETISQIDRLGVHRAVIVDPVDVPVSDVVPGALDVPVPVLVPDFAEVEPGDGGNPEDSGNPNIDRNPVNDGGGGDLGDDVRVAHPPAPNSVNADVDDILADDAYYRGEIHLIDEPIEQPWIHEATTNMTFDDEEPPDNEEPCCLCRKNARKMAFTPCGHRCLCHECTFKLNKFARRQNAHRTHYQIKCVLCLIPSTNIVYVRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HI15</accession>
    <name>A0A8J2HI15_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS5810</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5090945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HI15"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5090945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="74" mass="8473" checksum="FF2D751E66307D0C" modified="2022-05-25" version="1">MFLPRILLEDRVCLILITWRSREPGVHGDALTRGHCCCFHGLSVGKEYQQHCDSMALHSSWCLSNYHAIDSPIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HI31</accession>
    <name>A0A8J2HI31_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Phosphodiesterase</fullName>
            <ecNumber evidence="8">3.1.4.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HICCMSTLAB_LOCUS9294</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="8">Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the cyclic nucleotide phosphodiesterase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.-" evidence="8"/>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5099907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HI31"/>
    <dbReference type="OrthoDB" id="295473at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004114">
        <property type="term" value="F:3',5'-cyclic-nucleotide phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1300.10:FF:000003">
        <property type="entry name" value="Phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1300.10">
        <property type="entry name" value="3'5'-cyclic nucleotide phosphodiesterase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023088">
        <property type="entry name" value="PDEase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002073">
        <property type="entry name" value="PDEase_catalytic_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036971">
        <property type="entry name" value="PDEase_catalytic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023174">
        <property type="entry name" value="PDEase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11347">
        <property type="entry name" value="CYCLIC NUCLEOTIDE PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00233">
        <property type="entry name" value="PDEase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00387">
        <property type="entry name" value="PDIESTERASE1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55781">
        <property type="entry name" value="GAF domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109604">
        <property type="entry name" value="HD-domain/PDEase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00126">
        <property type="entry name" value="PDEASE_I_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51845">
        <property type="entry name" value="PDEASE_I_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0140">cGMP</keyword>
    <keyword evidence="4 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 7 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDEase" evidence="9">
        <location>
            <begin position="318"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="5">
        <location>
            <position position="396"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="396"/>
            <end position="400"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="400"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="438"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="439"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="439"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="439"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="550"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="550"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="601"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR623088-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR623088-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR623088-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAG5099907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="678" mass="77945" checksum="95F40665A44C8CC2" modified="2022-05-25" version="1">MTLQLESTTPEKMLSLIQDLADLPCSIMQKNLNKYIQSKSGANISFLAPILPESKEMVIHVVGEKILDRGLRIPISQSNANDRVLHRVIKSRKSLKVNCTELDQELLEHLNSVSKLVPDTLLSIPIEHPSEQYIALVVTLVNYPEDQDTEDICIKIVEECFRYCLGMLLNVLRCQEETRLKVQCQDLLTVSRKLFTHLGDLPDLLREIMVEARKLTNAERCSLNAYEHPLFYSGIDEVTGFKTRNILCFPIRDENQIIGVAQLCNKINGLYFDVCDEEVATAFSIYCGISIMHSIIYKKIQDSQARSKLSNELMMYHMKVEEEAVQALLNCRDDHSPKDFDKFHFTPRNIPHQHTPCYVLKMFDELDLITVWRIKRKTLARFILYVKKGYRDAPYHNWVHAFSVAHFAYLMIKNLNLVKNNYMTRLQSLVFLVSGLCHDIDHRGTNNSFQTQCGTVLASLYSSEGSVMERHHLAQSMCILNTEGCNIFENLTSDEYSEALDLLRNNILATDLASHFRSIDEQDEMIKQGFNNEDPIHQKLLHAMLMTCCDLNDQTKDWKTSKKTAEQIYDEFFSQGDLEKSMGTAPIEMMDRERASIPDLQVQFITNLVLPLFENLSTLFPTADCLVEAIKRNREIWRVAIPIFHRYSEIGIKGMDVLLDPSIENEILTAYHTQTVPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HI66</accession>
    <name>A0A8J2HI66_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS9662</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5100589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HI66"/>
    <dbReference type="OrthoDB" id="7701450at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5100589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="348" mass="40583" checksum="06B91C3646E3F7C8" modified="2022-05-25" version="1">MFSVRETELHFFRMLEQSIKQAYESYQRYNRQSSQVLNIPDLYTHTGEHQMIEIASGSKIYFPISVKKQIEKTSEQEDGSCDWETIVKLALKEVYDDNISNYSAKGKDANGRPPINIKLYNAIFDWVKKKVGPNKIITSKMFNATINKYSANKRGNENQKLNCSKHSKHPDATLSNKLMKFLYYLVTEENLLFFQKIVKISEESYNMQQKEMLPERQTHQLSNVYTEPAPIKIKISPHYEIYLPRSTHLYIERKSEIARGKYDWRILVKETLLEVYGDTIKNYSAKGVRGGSPGINPELYRALYDWATTVTDEECILDSQFAECVNQVTRNKRKAKKIKGQKMQPQEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HI67</accession>
    <name>A0A8J2HI67_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS9876</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5100803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HI67"/>
    <dbReference type="OrthoDB" id="7690086at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5100803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="321" mass="37714" checksum="16582FBC9AF7E637" modified="2022-05-25" version="1">MRINIIAVNSDSIPRSIRRCRTYRNLVGQVLNNSPLTTDQLDDRIIEEQEEDMEDAPDQPSESTSHRMIQTEKTNNIMWHNDSLEESIDKEDDDEDDDDEEEDPTFEGDNNLTRENNQSSFLDPPEIKVTMDDSLLQKAHEYRVNFDGFAQINRFNSIEELHDFIKNTMKISENSNNNCSEDNSNRQELYLSILLNERPEDRFKKLFDESRLTVRRLLTRNEHILRKLFASASLEIFPSPLARVEETAEAADEDVVCSDLQDDEVDENMKRWYMIEMIGLWLKMITDVTSYREAIKRRVLMNSWGIEDNQYEGIVVPLEYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HIA2</accession>
    <name>A0A8J2HIA2_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">chitin synthase</fullName>
            <ecNumber evidence="2">2.4.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">HICCMSTLAB_LOCUS8296</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>[(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n) + UDP-N-acetyl-alpha-D-glucosamine = [(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n+1) + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16637"/>
            <dbReference type="Rhea" id="RHEA-COMP:9593"/>
            <dbReference type="Rhea" id="RHEA-COMP:9595"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17029"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="EC" id="2.4.1.16"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the chitin synthase family. Class IV subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.16" evidence="2"/>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5096611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="370884at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004100">
        <property type="term" value="F:chitin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006031">
        <property type="term" value="P:chitin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04190">
        <property type="entry name" value="Chitin_synth_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000139">
        <property type="entry name" value="Chitin synthase 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004835">
        <property type="entry name" value="Chitin_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055120">
        <property type="entry name" value="Chs-1/2_IV_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914">
        <property type="entry name" value="CHITIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914:SF42">
        <property type="entry name" value="CHITIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03142">
        <property type="entry name" value="Chitin_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23000">
        <property type="entry name" value="ChitinSynthase_IV_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="74"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="131"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="170"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="196"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="228"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="257"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="301"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="380"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="410"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="920"/>
            <end position="947"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="953"/>
            <end position="970"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="977"/>
            <end position="1000"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="1006"/>
            <end position="1027"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="1039"/>
            <end position="1058"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="1280"/>
            <end position="1299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="1339"/>
            <end position="1358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="1396"/>
            <end position="1417"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin synthase chs-1/2 N-terminal putative transporter" evidence="16">
        <location>
            <begin position="68"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1170"/>
            <end position="1213"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="1069"/>
            <end position="1099"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="15"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="1181"/>
            <end position="1197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="1198"/>
            <end position="1210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00046329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF23000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CAG5096611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="1609" mass="183303" checksum="E28BD93B689140F2" modified="2022-05-25" version="1">MPKNHQQNGMMGANDPDDFSDDDTTPLTHEYGESQRTIVETKAWDVFRNPPPKIDSGSMANQKCLDATIQIIKVIVYLLVFIIVLVSGVISKGAIIFMTSQLKSDRVIVYCNKELGRDKQFIVTLPEEQRIAWAWCIIFAYAAPEFGTFFRSCRMCIFKSWKKPISSHFLLVFIMETFRVVGLASMFFAVLPELDAIKAAMITNCVCFVPGLLGLLSRSSSKDESRKCILVLVDLMALVAQVSGFIVWPLLDSSKQSLWLIPPTLIFVSCGWWENYVSMQSSIGFIRTLGRVKKELRLTRYFTYLFISVWKIIAFFISSLVIFHLKGQNIGHFFTMFGSAFREQKITVTGVRQSVVGAIPDLSEILPTGDTETINSDLNSIVYVLLIQIVGSYFTYIVGKFGCKILIQPFSYAFPVNLTIPVLISLLITACGLRNGDPCFFHGTIPDYLFYESPPLYFLNDFISKQYAWVWLLWLLSQTWITLHIWTPKCERLAATEKLFVVPMYDSLLIDQSLGLNRKRDDQPEVKVEDLAEIEREKGDGDYETIYEQTDGSTTPPSAVKSSDHVTRIYACATMWHENKEEMIEFLKSILRLDEDQCARRVAQKYLKVVDPDYYEFETHIFFDDAFELADHDENETQVNRFVKLLVGTLDEAASDVHQTRMHVRAPKKYPTPYGGRLVWTLPGKTKMIAHLKDKNKIRHRKRWSQVMYMYYLLGHRLMELPISVDRKEMIAENTYLLTLDGDIDFQPAAVKLLVDLMKKNKNLGAACGRIHPVGSGPMVWYQMFEYAIGHWLQKATEHMIGCVLCSPGCFSLFRGKALMDDNVMKKYTTKSEDARHYVQYDQGEDRWLCTLLLQRGYRVEYSAASDAYTHAPEGFNEFYNQRRRWVPSTIANIMDLLMDAKRTIKINDNISLPYISYQILLMGGTILGPGTIFLMLVGAFVAAFKIDNWTSFYYNIIPILLFMVICFTCKADIQLLCAQILSTAYAMIMMAVIVGTALQLGEDGIGSPSAIFLISLTSSFLIAACLHPQEFWCIVPGIIYLLSIPSMYLLLILYSIINLNVVSWGTREVQVKKTKKELDQEKKEAEEAKRKVKQNSLLGFLQNGAGSNDDEQGSIEISFAGLFKCLLCTHGKPSDEKQQLIAIADSLEHLGKRLEIIERAVDPQGHILARRRASSASSRAPDHLGPIEEESRKDQNDSVSDTETETSQPHDVARDVNFHSQPYWLHDEGLKKGEIDVLSMQEEQFWKDLLEKYLYPIDEDKAEKARIAKDLKDLRDQSVFAFFMMNALFVLIVFLLQLNKDLLHVKWPFGIKTNITYDDFTQEARIAADLIELRNKSVFAFLMFNALFVLIVFLLQLNKDQLHVVWPLGIKTNITFVEETSEVHISKEYLQLEPIGLVFVFFFALILIIQFSAMLFHRFGTLAHILASTPLSWYCCKKTKDLSEEALLSKHAVEIVRDLQRLDGMEGDYDEGSGSGPGRRKTIRNLEKSRRKTQAINTLDVAFRQRFFSMVEENELPRNMTTRQSTKAFKAFEGRRNSIMALRKKSQMQTLGANNIYGGVGNPLGIQPRPTRSSQISVKDVFGDAGHVNIGFDIGESPRNSLKLQPMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HIA9</accession>
    <name>A0A8J2HIA9_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to Bahd1: Bromo adjacent homology domain-containing 1 protein (Mus musculus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS8838</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5097709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HIA9"/>
    <dbReference type="OrthoDB" id="1922186at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005677">
        <property type="term" value="C:chromatin silencing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031507">
        <property type="term" value="P:heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001025">
        <property type="entry name" value="BAH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053032">
        <property type="entry name" value="BAH_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043151">
        <property type="entry name" value="BAH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46576">
        <property type="entry name" value="BROMO ADJACENT HOMOLOGY DOMAIN-CONTAINING 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46576:SF1">
        <property type="entry name" value="BROMO ADJACENT HOMOLOGY DOMAIN-CONTAINING 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01426">
        <property type="entry name" value="BAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00049">
        <property type="entry name" value="WILMSTUMOUR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00439">
        <property type="entry name" value="BAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51038">
        <property type="entry name" value="BAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BAH" evidence="2">
        <location>
            <begin position="933"/>
            <end position="1084"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="128"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="215"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="266"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="838"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="59"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="269"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="850"/>
            <end position="866"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5097709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="1085" mass="119308" checksum="15602BD7BF44E964" modified="2022-05-25" version="1">MLCLITKQTYLTCRLFVRYYQPAGPLIQHPPTLPPIKGPPPEPTPTPPQNSESSDDLVATSTTSGGTNSTAGGGFYRAYCPQYYGTPPQYQELCYPPTYPHPHPHPPPYYKYAPAYRRQYYSYPEAGGGGGAGGASSGAPGVVEYQPPPPPGEYSIPPYYAGYPPPPAPPPPPPNPAYLHAQGRPIVDHAAFQGCPCPMQSCPKNVDTGPLIGNGKGAPVASGPGLSLPPSALVGPPSPARGLAGLAPPHGANAWDTDRVQINTHHRNINNNNNNNNNNNNNNNNNNNNNNNNNNTNNNNNNNNNNTNNNNNNNNINNNNNNNNNNNNNNNIDNIASTTTSNNNSNNNNDNNSKTNTTNIQNQNQQLPSSTTHNNDCRAKEEQNSPSKHPKCACEKLSCTSTCEVKIETLSPAEASVPSPSLVPQSPSSLQQPQALSLQKLASISPQLSNMRTFKTENNNVKCESCSVGIVSDTSALSCVSNCNVKCEQQDDYKCGIIKCEQCLKEDREMAILEIDKDSGILMIDDKLDAAEAEVKEEISDVVVVNIDSESWTKPDYEDTVSETIEDDTDNKSESDITRREILITSKCQKLTKRKLSLDSLSSLSPKKIKLDKRTLSVGSGRDINDHRVPNPMNEEYLINRTNFGDSAALGGDFGNVGGEIGPLGVKKKVKKENFKRKAEEGNIAESNSKKVKKSVSTCPVKTASAMSIMETINNVIQQSVQMTSRTDDDDINIVSTCNDSSNSDSINISNVIVNSGKKERDSKRKSGNLLSIIKNVPKKADKLGFKDCKLIDKDKGGKEGKGRVKKMMVKNKVLEDKGKVEVKSAGGKGRIVKIQDKEDKEEKKPAALVKKKSNKKSTNTKKICGKKIPGRDESVGGVLDSFSSLTKKSFLKPKWSNGWSWEGDSYEAKVYLTNEESAIRRCYKSMKHVSGDVLRPRDCVLLKSGPRKADLPFVAKIAALWENPDDGEMMFSLLWYYRPEHTEQGRTDFDTEDEVFASRHRDANSVACIEDKCYILTFNEYCRYRKNLRRIEENLDCPGLIVPPGEQSYPRESRQPPIPVPSDMVLFCRRVYDYRGKKLVKNPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HID5</accession>
    <name>A0A8J2HID5_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similar to Tnc: Tenascin (Mus musculus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS9937</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5100864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HID5"/>
    <dbReference type="OrthoDB" id="504708at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39069">
        <property type="entry name" value="ECDYSONE-INDUCIBLE GENE E1, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39069:SF8">
        <property type="entry name" value="FI17111P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EGF-like" evidence="1">
        <location>
            <begin position="16"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="1">
        <location>
            <begin position="85"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="1">
        <location>
            <begin position="135"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="1">
        <location>
            <begin position="218"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="1">
        <location>
            <begin position="259"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="1">
        <location>
            <begin position="300"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="1">
        <location>
            <begin position="506"/>
            <end position="548"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5100864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="551" mass="61945" checksum="50F0DF427671C36A" modified="2022-05-25" version="1">MSKCVPLLNEFCWNESCAPENSMCINNECKCKRGFLAQSNDQCSTILLKLSCEIDANCKLIEFSKCSLNKTCVCSENIIATSPIFCSLLIGEFCNNNRECGIRNSECVNYRCQCKPQYLPYLNNSECQLSYLGMSCENSTYCEKRIKNTICINNICECNANYYSREDNSCRTLAILDCENNLECSKLINSLCIDKFCQCKPDDVLMKGKCLPRYLGGPCEKTSDCSNIKFAVCLKNQCICNGGFSSFNQTLCARDLGTICLGDEDCLLKNSHCYQHYCECRDGYIQDSTKKCLPMELRGFCFDDADCKLIKNARCSSENKCICKINYVEINEVSCVALLDGSCSHDNECAVAESVCVENKCQCDSENFQRFDEQCFHHKYNAKLSTKTSCSLDTDCIDIPHAKCWNTSMCACESNFIQLKSSVCAPLLGGYCTQHNDCIAKHSVCIKNKCQCDFAYTEKLSSKCEPTQSLYSCLNVSECVEHYHFECSEDKKCVCKANNIAINNSTCLPNLNGYCWKHDQCAVLNAECIDFRCQCNSGYNSVSTNMCVLNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HJ95</accession>
    <name>A0A8J2HJ95_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS11354</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5103127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HJ95"/>
    <dbReference type="OrthoDB" id="6621861at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035295302" evidence="1">
        <location>
            <begin position="26"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5103127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="116" mass="13713" checksum="35CEECFC654834A0" modified="2022-05-25" version="1">MEITSWKTSVILSSVMFMILFTATAEKFTKDHKQTLDKVVKILSANKPHFQSYENFEERTERINKELDQAMNIINVVKEIDRFVTNKIKMIVKQLNAIYDIHYSDRSQSSFNVYEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HJI7</accession>
    <name>A0A8J2HJI7_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS9961</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5100888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HJI7"/>
    <dbReference type="OrthoDB" id="5855668at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5100888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="131" mass="15187" checksum="ECD82A350F1B8D2D" modified="2022-05-25" version="1">MECYLVSVVPYIWSILIGDHIVLILYNMELHRQYAKWFKNCNYVLMIKGQPPASIEKPENKPDKKPQTEVESVNNSANDYLLCKICYNYKLGWCSSLAYTLWLVLGVRYISMTSCPVCREPIKLVALFIIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HJK9</accession>
    <name>A0A8J2HJK9_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS6840</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5093450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HJK9"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5093450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="150" mass="17711" checksum="90697D4EAD3EE620" modified="2022-05-25" version="1">MYPKAWKEFQTDFKTCTALQHTSKAYSRIWVSYLVTDYSVHIHRLEAVKLSLVRHIKYLWGLQAQKSDRDFRTAQMDLCLFQDIINTKIDSSEILNETKLLVLNYKDFERKKKLLDLAQDMKRFITSGSRNRIFATVNEYGNDLNSFNSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HK18</accession>
    <name>A0A8J2HK18_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS8947</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5097927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HK18"/>
    <dbReference type="OrthoDB" id="6338233at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010972">
        <property type="term" value="P:negative regulation of G2/M transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026187">
        <property type="entry name" value="Aven"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16524">
        <property type="entry name" value="CELL DEATH REGULATOR AVEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16524:SF2">
        <property type="entry name" value="CELL DEATH REGULATOR AVEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5097927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="262" mass="30132" checksum="F9CF69E07A64CAAA" modified="2022-05-25" version="1">MDKQKHRDSRRKKDKLNHKNKKRTSKPAEPEPSPAKPYLLRNFDRTGVSSDEDEFDDDFFGFDYVRKAALVQPSASFADLVDQDESTPKPSNDFSYLANTTLTSGYFQFKSEKNWLVDTSKFSDLLAIDVENLSAVFNCIPFNQTVEVDDKYFTEDQLTLFNTAAEEAKKIYEEELRNKELQQKLSDSNNHKLREMSSKLESIDDDVVVEEDLEFLLSLKEPVKTSSITSVVTPKYTEEPKVTNTPTKSIDLEKWLDSVLDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HKJ1</accession>
    <name>A0A8J2HKJ1_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Similar to ndufaf3: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 3 (Xenopus tropicalis)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS10855</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5102118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HKJ1"/>
    <dbReference type="OrthoDB" id="20681at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032981">
        <property type="term" value="P:mitochondrial respiratory chain complex I assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1230.10">
        <property type="entry name" value="MTH938-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036748">
        <property type="entry name" value="MTH938-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007523">
        <property type="entry name" value="NDUFAF3/AAMDC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21192:SF2">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX ASSEMBLY FACTOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21192">
        <property type="entry name" value="NUCLEAR PROTEIN E3-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04430">
        <property type="entry name" value="DUF498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64076">
        <property type="entry name" value="MTH938-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5102118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="199" mass="22448" checksum="EA3093FB5B13452B" modified="2022-05-25" version="1">MTSLIYRQLSVYRNKLSEQCKFVVLNRLMSMHKGAYEGEGKTTVTILNKDPEYGLMIDGVSCVGFKLNIGITVLGAMILFPRTAIGWGIGSASDIHKDSLTIFKTIIPRPDIIILGLDDNYPRDAPFIKDFCKIIKDLNINMEVLPIIKACTTFNFLNAEKRYVVGAFLPPRVLERHDTQLIDDVAIRRAFRIPEKGID</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HKT2</accession>
    <name>A0A8J2HKT2_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Similar to PROP1: Homeobox protein prophet of Pit-1 (Sapajus apella)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HICCMSTLAB_LOCUS10547</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the paired homeobox family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5101645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HKT2"/>
    <dbReference type="OrthoDB" id="6159439at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007399">
        <property type="term" value="P:nervous system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000138">
        <property type="entry name" value="Homeobox protein prophet of Pit-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050649">
        <property type="entry name" value="Paired_Homeobox_TFs"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24329:SF520">
        <property type="entry name" value="ALX HOMEOBOX PROTEIN 1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24329">
        <property type="entry name" value="HOMEOBOX PROTEIN ARISTALESS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 6 7" id="KW-0371">Homeobox</keyword>
    <keyword evidence="5 6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="9">
        <location>
            <begin position="207"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="6">
        <location>
            <begin position="209"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="188"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAG5101645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="383" mass="41897" checksum="DB2196F72C2F39AC" modified="2022-05-25" version="1">MSSLRRRRRRKRSGFPKVCRLFSRDLFQGHNGIILANDLSGGNGGGSVGGTSVGVGGSLPTTALSLDHQQFNIFPAIFSRQLNFSAAAANCSQNKLMDELRPNLGLLGVGLVENDTFHINHNQEKRKCSSASSNEQDFGLYGVHQGLEASPPTPAATPGRNSVGNATSVGYAVFAGAEGAFKKLKPEPCASSPHIGHTPTTASCPTPARRRHRTTFTQEQLAELESAFAKSHYPDIYCREELARSTKLNEARIQVWFQNRRAKYRKQEKQLQKALAPIPTCQGAMMRNIYPGAGRGYQPYAHPHNSINGINRYPQMGASSYPSMPQPFSMSHSASNMSAVTGMRQDAMGMSAEDEWYNKSISALRMNTAHHPNLAAPMLQYQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HL12</accession>
    <name>A0A8J2HL12_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Similar to rho-5: Inactive rhomboid protein 1 (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HICCMSTLAB_LOCUS9830</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase S54 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5100757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2146116at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042058">
        <property type="term" value="P:regulation of epidermal growth factor receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050708">
        <property type="term" value="P:regulation of protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1540.10:FF:000025">
        <property type="entry name" value="Putative rhomboid family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1540.10">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051512">
        <property type="entry name" value="Inactive_Rhomboid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022764">
        <property type="entry name" value="Peptidase_S54_rhomboid_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035952">
        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45965">
        <property type="entry name" value="INACTIVE RHOMBOID PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45965:SF3">
        <property type="entry name" value="INACTIVE RHOMBOID PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01694">
        <property type="entry name" value="Rhomboid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144091">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1530"/>
            <end position="1549"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1561"/>
            <end position="1580"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1586"/>
            <end position="1604"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1616"/>
            <end position="1636"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1642"/>
            <end position="1659"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1671"/>
            <end position="1692"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S54 rhomboid" evidence="9">
        <location>
            <begin position="1520"/>
            <end position="1657"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="74"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="265"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="482"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="567"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="689"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="852"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1016"/>
            <end position="1067"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1091"/>
            <end position="1188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="74"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="112"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="298"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="592"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="613"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="690"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="857"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="867"/>
            <end position="876"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1023"/>
            <end position="1034"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1091"/>
            <end position="1107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1109"/>
            <end position="1138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1168"/>
            <end position="1177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAG5100757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="1728" mass="193358" checksum="27787813BDBC4B62" modified="2022-05-25" version="1">MILAPIPDYTQLNLRCPDSGPRATRMPTDDDYGRRERLLLHQNPASQFGVSSVSSVSGGNPTISGSQIVSNTCNNNSINNDLSSYQKQSESKAPPSSGTSPERYQKACEGYSGSNEKTQSSVSNNYGVQSTMDKYEKQSDKLQSQQIDDTTLYGEQSRSISSCCERFSKSQNSEKFNQISICSGGNQNIHQYSRQQQSVPQSSINQLPRYSEANSVISDQRLGLQSNDRFQRMDRFQSDSTSGSSPKTSTVGEYANSGILVLSTGKPFSPETFPSPPSPAPTNDRFVPPPPLSPSPSDKYTSTHSLASYPSGDRILQSGSPNTRDRYGTAPASPILKNRFASAEKLLAANSATSTNATHDAKDQQQRYTSSTERLLVNGSPVLCSLQRDSVNLFSVSTASTESNRYPLSPERLVTSSPMHAPVPERFASKTKDRFISESPNHERYQRQETLGIYHDRFSTIANCERYLSGTQNPENLHHRYSSTERALANSSTTDALQPRCFPSTEQYPKYSERSDRCTSSNSPAPTEYSCRYSTFQDTAGQSRYSADRFNDLTLQRYSQSRSNDRFNDRYLSSLSPTHDGRITSESNRYASTSSTERLLVSSSPSSSENSRYQNLYASSGQTSNDRFNQQSPPLDNNGTIRSYQNQVSTKSDKFIQVSKSISSYDRYQLTSSDQYEHSNQERMYGFDKYSNSTAGNDRYQGSEQRYHGNSESFSPARVVGDKYLSLPKPKDNYPTGRIISSCSSVINGNEARGFGNPSGVSSYVPPNAHTPVERYVPQPPPEVLFPERYVDRYVSSTAHTPTYVPTADPGDPYMRRDLGFHHHYRLPPPGYPYHQSHFRFRGFAYASPGRIGGSPGSSSSSSSTSVQRDFSTSPSLRPKVRASAIEFTSTIRPSQSCCGDSVGGQRNCCQVRRSLPPGALSSIPSNQSTHSSWITLFASFFILSAGPPKMSISVAYLFMTLLILYIGARVESRDFINSNSNSLGSRRRVPGTIKLRRSTSSGTYIFPLTISAPQQNTLTRQRPQEKSESRPESRSFPPSVISIFETGAPDTESVNKGENAVSEEEEAFFQKFTPSPTISTHQQSQIPIDQAGASNIKTDEITSLSNKPIDKNERISDRSDVMDELGRYASQKEEKSVLDGAQPQTRRHAVTPPKDHYTSRTTSWRRSRNDARRSDQESTTLSHQQDDGLVLRREITTGRTRISPNTIDRVFDNSNRRQYGMGVVGRFFGRSFRKSVAHKPQVKKQLDDIEDHRPYFTYWITTVQVLVLIISLACYGFGPIGIDLNHRSGLVLVTSLSLQQVDYQEPANFWIGPRAADLIHLGAKFAPCMRRDMKILKEIDVWRERERDTACCIRNDDSGCVQSSKADCSNTISTWKKWGPGDNGPGGRISGSVCGLDPKFCDAPASIAPYEWPDDITKWPICRKTNPFSQRFRSNNGHAQNNNNFPVGRYKDKMAEHMVCEVIGHPCCIGIHGMCRITTKEYCDFVHGYFHEEASLCSQVECLHDVCGMIPFLHPEWPDQFYRLFTTTFLHAGILHLAITLFVQYYLMRDLEKLTGSLRIALIYFTGALAGNLASAIFIPYRAEVGPAGAHFALLATLVVEVLNCWPMLKHPRRALTKLILILVGFLILGVLPWVDNYAHFFGFIFGFFASYALLPFISFGEYDRRRKIILIWICFVLILGLFGLLLALFYNIPVYECEICKLFNCIPFTRDFCASQNINFKREEPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HL52</accession>
    <name>A0A8J2HL52_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">purine-nucleoside phosphorylase</fullName>
            <ecNumber evidence="3">2.4.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Inosine-guanosine phosphorylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HICCMSTLAB_LOCUS10491</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>2'-deoxyguanosine + phosphate = 2-deoxy-alpha-D-ribose 1-phosphate + guanine</text>
            <dbReference type="Rhea" id="RHEA:27738"/>
            <dbReference type="ChEBI" id="CHEBI:16235"/>
            <dbReference type="ChEBI" id="CHEBI:17172"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57259"/>
            <dbReference type="EC" id="2.4.2.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>2'-deoxyinosine + phosphate = 2-deoxy-alpha-D-ribose 1-phosphate + hypoxanthine</text>
            <dbReference type="Rhea" id="RHEA:27750"/>
            <dbReference type="ChEBI" id="CHEBI:17368"/>
            <dbReference type="ChEBI" id="CHEBI:28997"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57259"/>
            <dbReference type="EC" id="2.4.2.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>guanosine + phosphate = alpha-D-ribose 1-phosphate + guanine</text>
            <dbReference type="Rhea" id="RHEA:13233"/>
            <dbReference type="ChEBI" id="CHEBI:16235"/>
            <dbReference type="ChEBI" id="CHEBI:16750"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57720"/>
            <dbReference type="EC" id="2.4.2.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>inosine + phosphate = alpha-D-ribose 1-phosphate + hypoxanthine</text>
            <dbReference type="Rhea" id="RHEA:27646"/>
            <dbReference type="ChEBI" id="CHEBI:17368"/>
            <dbReference type="ChEBI" id="CHEBI:17596"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57720"/>
            <dbReference type="EC" id="2.4.2.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Purine metabolism; purine nucleoside salvage.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PNP/MTAP phosphorylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.1" evidence="3"/>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5101589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HL52"/>
    <dbReference type="OrthoDB" id="10261782at2759"/>
    <dbReference type="UniPathway" id="UPA00606"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004731">
        <property type="term" value="F:purine-nucleoside phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009116">
        <property type="term" value="P:nucleoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09009">
        <property type="entry name" value="PNP-EcPNPII_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="entry name" value="Nucleoside phosphorylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000845">
        <property type="entry name" value="Nucleoside_phosphorylase_d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011268">
        <property type="entry name" value="Purine_phosphorylase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11904">
        <property type="entry name" value="METHYLTHIOADENOSINE/PURINE NUCLEOSIDE PHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11904:SF9">
        <property type="entry name" value="PURINE NUCLEOSIDE PHOSPHORYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01048">
        <property type="entry name" value="PNP_UDP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="Purine and uridine phosphorylases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Nucleoside phosphorylase" evidence="11">
        <location>
            <begin position="55"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAG5101589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="377" mass="42241" checksum="D3F753D4BB3BBA7E" modified="2022-05-25" version="1">MPFLDTTNGNGVDDKSNENEFLNAVVKHVPHSTYSFEVLQDTARYLLDRTSIRPKIGIICGSGMSESEHSELCPGSIAESLTQQQIFPYEDIPHFPKSTVKGHVGQMVFGYLQDVPIMCMQGRFHYYEGYPLWKCAMPVRVMKLIGVTHLIATNAAGGLNPNYKVGDIMLVQDHLNIMGFAGNNPLQGPNDDSYVSKTAAPATGNYFADSRKFDLSFARNSTYFFFISLFYKILFHDIALLMPKGFGPRFPPMNKAYDRELLKVGQEVAEEMGLSDIVHRGVYTCLGGPSFETVAELKMLRMIGVDAVGMSTAHEVIAARHCNLTVFAFSLITNLCVFDYDCHDEANHEEVMDVGKSRQPVLEDFVRRMVQRIKAYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HLD3</accession>
    <name>A0A8J2HLD3_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Similar to pnr: GATA-binding factor A (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">HICCMSTLAB_LOCUS10579</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5101677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HLD3"/>
    <dbReference type="OrthoDB" id="2162994at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045165">
        <property type="term" value="P:cell fate commitment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00202">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.50.10:FF:000001">
        <property type="entry name" value="GATA transcription factor (GATAd)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.50.10:FF:000002">
        <property type="entry name" value="Gata transcription factor gatad"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039355">
        <property type="entry name" value="Transcription_factor_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000679">
        <property type="entry name" value="Znf_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10071:SF337">
        <property type="entry name" value="GATA-BINDING FACTOR A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10071">
        <property type="entry name" value="TRANSCRIPTION FACTOR GATA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00320">
        <property type="entry name" value="GATA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00619">
        <property type="entry name" value="GATAZNFINGER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00401">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00344">
        <property type="entry name" value="GATA_ZN_FINGER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50114">
        <property type="entry name" value="GATA_ZN_FINGER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0010">Activator</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="GATA-type" evidence="13">
        <location>
            <begin position="161"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="domain" description="GATA-type" evidence="13">
        <location>
            <begin position="215"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="89"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="260"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="17"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="106"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="291"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CAG5101677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="405" mass="44551" checksum="6FE9D69AAE84ED5E" modified="2022-05-25" version="1">MFHGSGSGGYGAGTDYQTQSQQQQQQQQQQQQQQQQHTQQLQAPVYVPSSRPAIPAATAQYHSFPGSASPAWEKTTSWQHGVDSYAHHALTGHTGGSAASMGAHSTHGHPHAAHPHTGHPHSTLTSPFYAQNVAMMSSWRAYDSAGFQRASPYDTAMDFQFAEGRECVNCGAISTPLWRRDGTGHYLCNACGLYHKMNGMNRPLIKPSKRLTATRRLGLCCTNCGTRTTTLWRRNNEGEPVCNACGLYFKLHGVNRPLAMRKDGIQTRKRKPKKTSDSTASRTSTNEHETSTSTTSSPSNDLKSSQQHHQSESTKSSSSVPAERPVYLGHTPLLATGVIPTVKTEPRSCDGLIGQPYSSYYQHPHQHQLDTPTSEHQHQQSYYNAQETYHHQHHVASAAKLLASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HMB9</accession>
    <name>A0A8J2HMB9_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS11292</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5103003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HMB9"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5103003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="90" mass="10774" checksum="C18FA945D7B66D3D" modified="2022-05-25" version="1">MNLSNSYTERKLRQHRKNQHTESLVLDYDVTNSSSFEENKFFESRLFFYQCTIAPRIDLQLLKDLRVANRLLHSTHYSPNTTHITDRTQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HN82</accession>
    <name>A0A8J2HN82_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Similar to MYO18A: Unconventional myosin-XVIIIa (Homo sapiens)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HICCMSTLAB_LOCUS11941</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5104316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HN82"/>
    <dbReference type="OrthoDB" id="2914378at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016459">
        <property type="term" value="C:myosin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000146">
        <property type="term" value="F:microfilament motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1590">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.720">
        <property type="entry name" value="Myosin VI head, motor domain, U50 subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.270.10">
        <property type="entry name" value="Myosin, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000048">
        <property type="entry name" value="IQ_motif_EF-hand-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001609">
        <property type="entry name" value="Myosin_head_motor_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140:SF706">
        <property type="entry name" value="DILUTE CLASS UNCONVENTIONAL MYOSIN, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140">
        <property type="entry name" value="MYOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00612">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00063">
        <property type="entry name" value="Myosin_head"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00242">
        <property type="entry name" value="MYSc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51456">
        <property type="entry name" value="MYOSIN_MOTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0505">Motor protein</keyword>
    <keyword evidence="3 6" id="KW-0518">Myosin</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myosin motor" evidence="8">
        <location>
            <begin position="1"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="702"/>
            <end position="743"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAG5104316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="746" mass="83262" checksum="B3794A8ED3C9D0C5" modified="2022-05-25" version="1">MNSNATRFTQIFSLDFDQSGQIASASIQVLLLEKSRIGRRNNGDPTFHIIYRLLAGAEGQLRKELYLGNLVTENNPFITPLQKHEEKQRAVVDFNRIVGAFKILGLSEADEKVIWTVIAGIYHLSCAGAVKTNVNSQSSRWQFARAECAEKAANLLGTSVEELSRIIFSSNADGITTTAGSGGGGGGGSRGSLRASSPIDSASNYSGLDALEGFIVGLYTEVFHCVASLINKVISSPVHTVSSLLLCDTPGFQNPASCGHQTGANFEDLCHNYLQERLQLLFHYSSLVAPKNRYIQEGINIEHDEDYDEENSGVGSPQDLISLVDRGQQNTATMIRSSQNDLTGRFQGEKKGLLWLLDEEAVCAGGSDESFMDRLFSLYGDRDYQLLLRKAPGNNQFVLQHLQGTNPVLYTATGWLKATRENPVTKSAINILQESTREDVNRLFVQVRSTGITGALMTSSISGLEGSQSLRRASSIRRTFTTVKRKSACLQIKFTVDGIIETLRRTRVKFVHCLLPQHNSGCTDKSFVTMKLPKNDNGVINVPLLRSQIRGGQIIDAMRLHKVGFPKHLPLGEFRRRFGLLSSDYAANVRSSSPVEDERRVVEDMLLTMDVDAASYRVGQSQIFFRAGALERLESQRDEKLTGHIVLLQARCRGYLARKKLNTLKLQDLAVRCIQRNVRKLMSVREWPWWRLYVKVAPLLNVHRTEDQLKARTEELELLRAKVEKLEQERNHLKHDNVKLEAKPTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HNF9</accession>
    <name>A0A8J2HNF9_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS11582</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5103583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HNF9"/>
    <dbReference type="OrthoDB" id="7701779at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="160"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="163"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="197"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5103583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="286" mass="29982" checksum="7D9EAAD534F00357" modified="2022-05-25" version="1">MRFEQDTTCRGTHCASTPLQAPQKIRPKEEVEVVDGVFSASQDNRVLLLDNHRHNLNNLQQQHHQQHQSHLGGNRRRLFELEVNNTLESANTGLRGVAGGPGMAYPASAAGPTLNQHSAFSSINNSASGNGNGLLSSSHLPAPAAPRPTDFSVSSLLTAANNHPSHLGGSSSQGSASPPPGGPGSPAAAPETPPPHNNNNNNNNNSSSNNNNNNNHRDQIGHSAAEAAAANYFNALAAAGFCNPSGVHLAHNPNNPHHLSAKGLLGSPHHHPQFNLHGITPQVSFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HNZ6</accession>
    <name>A0A8J2HNZ6_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF4773 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HICCMSTLAB_LOCUS10019</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5100946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HNZ6"/>
    <dbReference type="OrthoDB" id="5952164at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031941">
        <property type="entry name" value="DUF4773"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36299">
        <property type="entry name" value="AGAP008005-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36299:SF3">
        <property type="entry name" value="FI03431P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15998">
        <property type="entry name" value="DUF4773"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035153113" description="DUF4773 domain-containing protein" evidence="2">
        <location>
            <begin position="23"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4773" evidence="3">
        <location>
            <begin position="66"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="233"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="301"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="248"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF15998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG5100946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="358" mass="39251" checksum="28858F17160BDE22" modified="2022-05-25" version="1">MRLSTVFELLLIFLLIAFAAYGRVIDRDEATSLRRVARAAEGRVKQGNLGVSIMSLKQATENLNNYCKCDNDVCQCCRDFHIPVVALKGPGCASIRYFEKDNLEFQLSFGDNLLSSTVVNGKKSRTICVPMPGGFSKFCGRIYSIQRTSDSNFKACLGLELQSTPPPLTVLPLINKPTRRPIVAHPTTKAPKVQAETSTTEAPIVEIVGPFGFNAESSTEVSLKNGTEVAEEETTEAITESSVALEVESSTDVSEMSDSNKTEAVLEAAASDDNKQVVKVEKVPVIKKIIVGVTDKKSSITSNSIIGDDDDDEDDKKKKKKNKNLSTTEASKKDEYSISDILNRKITRRGRQSKVMRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HPA4</accession>
    <name>A0A8J2HPA4_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Olfactory receptor 156</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HICCMSTLAB_LOCUS12231</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5106380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HPA4"/>
    <dbReference type="OrthoDB" id="6614360at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005549">
        <property type="term" value="F:odorant binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004984">
        <property type="term" value="F:olfactory receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004117">
        <property type="entry name" value="7tm6_olfct_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21137">
        <property type="entry name" value="ODORANT RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21137:SF35">
        <property type="entry name" value="ODORANT RECEPTOR 19A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02949">
        <property type="entry name" value="7tm_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0552">Olfaction</keyword>
    <keyword evidence="8 11" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="9" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="31"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="119"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="176"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAG5106380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="398" mass="45775" checksum="485E95DA9F2903B3" modified="2022-05-25" version="1" fragment="single">MDIFDKPYYKSTKNFATGIGRWPYQSRMQSLIIITFLWIVFFLQAIPQIFALVMYSDDRDILIEALSSFIVDVALAAKYLNASYHADLIRNLFDKVQLDWKLMMNEGEKRVQEYHSETGRILATGYGAFLSASAMIFIMEPIVPRIYSLFSTSNESISFRFALPLEYVIFEKEDHYWLMLTISNTFVLIIIFGFISCDLIFITLLQHICGQFAVLGYRIENTPTAEITTNNEKEELIISQKIDQDASYQHLVSCIQMHSRALEYVFFDTLFAELLEECFAMSFGVVIGINLPIMSLTGFQIITQSSTVQQILKSLSFSGSQILHLFFDCYMSQKLNDSSSEIAQSIANIKWYNHSVRSQKLLVLMTVRSQVPCKLTAGKIMELSIENFALVKKKRDFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HPZ5</accession>
    <name>A0A8J2HPZ5_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CB1 cannabinoid receptor-interacting protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HICCMSTLAB_LOCUS10893</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Suppresses cannabinoid receptor CNR1-mediated tonic inhibition of voltage-gated calcium channels.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Interacts with the cannabinoid receptor CNR1 (via C-terminus). Does not interact with cannabinoid receptor CNR2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CNRIP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5102194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HPZ5"/>
    <dbReference type="OrthoDB" id="5920443at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031718">
        <property type="term" value="F:type 1 cannabinoid receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029204">
        <property type="entry name" value="CNRIP1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31952">
        <property type="entry name" value="CB1 CANNABINOID RECEPTOR-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31952:SF1">
        <property type="entry name" value="CB1 CANNABINOID RECEPTOR-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15043">
        <property type="entry name" value="CNRIP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0675">Receptor</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00026030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAG5102194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="167" mass="19128" checksum="B786075BA70B7268" modified="2022-05-25" version="1">MGGSDNYFRVTISLKKEPNTGPVYCKMEKTNKYRQQKTVKLFCDAMYRFDVSFKPPQQLELFSIDGELIEVTEQFRDGTACAYSAYYSTNNANPSPRGQRIELPMTIRVFGSEDLKSSLQIKYYRSDDHKHCEYGSKLHCIELDCSSLDGNLATVDKETYKKIGVDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HQ20</accession>
    <name>A0A8J2HQ20_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Similar to LCP17: Larval cuticle protein LCP-17 (Bombyx mori)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HICCMSTLAB_LOCUS13595</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5108959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HQ20"/>
    <dbReference type="OrthoDB" id="6493579at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062129">
        <property type="term" value="C:chitin-based extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008010">
        <property type="term" value="F:structural constituent of chitin-based larval cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050468">
        <property type="entry name" value="Cuticle_Struct_Prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000618">
        <property type="entry name" value="Insect_cuticle"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10380">
        <property type="entry name" value="CUTICLE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10380:SF173">
        <property type="entry name" value="CUTICULAR PROTEIN 47EF, ISOFORM C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00379">
        <property type="entry name" value="Chitin_bind_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00947">
        <property type="entry name" value="CUTICLE"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51155">
        <property type="entry name" value="CHIT_BIND_RR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0193">Cuticle</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035244834" evidence="3">
        <location>
            <begin position="17"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG5108959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="129" mass="14072" checksum="5B0F0926A82A7056" modified="2022-05-25" version="1">MKFIIVSLAVIAAVSAQQYSEQTQPPIPIVRQSQDVAPDGSYNYEYETGNGIQAQEAGSVVSGSEGPYVVAQGGYRYTDDQGNTFQVSYVADENGFQPQGDHLPVAPPIPEAIQRSLEYIRTHPQPQEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HQ29</accession>
    <name>A0A8J2HQ29_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Similar to Ctnnal1: Alpha-catulin (Mus musculus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HICCMSTLAB_LOCUS13560</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the vinculin/alpha-catenin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5108924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HQ29"/>
    <dbReference type="OrthoDB" id="9933814at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045296">
        <property type="term" value="F:cadherin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007266">
        <property type="term" value="P:Rho protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.230">
        <property type="entry name" value="Alpha-catenin/vinculin-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036723">
        <property type="entry name" value="Alpha-catenin/vinculin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001033">
        <property type="entry name" value="Alpha_catenin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030045">
        <property type="entry name" value="CTNNAL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006077">
        <property type="entry name" value="Vinculin/catenin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46342">
        <property type="entry name" value="ALPHA-CATULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46342:SF1">
        <property type="entry name" value="ALPHA-CATULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01044">
        <property type="entry name" value="Vinculin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00805">
        <property type="entry name" value="ALPHACATENIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47220">
        <property type="entry name" value="alpha-catenin/vinculin-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="723"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="724"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="750"/>
            <end position="761"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAG5108924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="761" mass="84532" checksum="AE8CF04AD4B21FB0" modified="2022-05-25" version="1">MEIPDPIIPAALEIKTRSIEQTLLPLVKQISTLVSHRERPLCSDRSLRAVARVGQAVNLAVERFVTVGETIADDNPEIKQTMYDACKEARVAGGAIEKLCECAMEDSLTDRGSVVRAARCLLGSVTRVLLLADIVVVKQLLLAKDKVARSLGRLESVSNFTEFVKAFSQFGAEMVELAHLTGDRQNDLKDERRRAQMAAARQVLERSTMMLLTSSKACLRHPECTSAKENRDTVFCQMRRAMDLIHYVVKDGVLDCNESQSYSNAQSPQQQDWDSSTVSSALKNFERMVETTRMTLNLPECRETLTSTIDTVVERTQDFTDSAYTSHEHRENILLLCDRVKLELNSLLRVGNSMQNYESGPTSPNSELDQAVLGVLKATRDLRLQLATTTMEQAGDLGQVTKAGQELVSTIRNLALASEIDRLQESSDRFHEYIEHILEVCKLLRHIALSESLQVSAKFTEINLRIYGPQVVTAAHTLARYPTSKIAKENLEVFADMWQWLMSDVTTVAKDVLELCQSRPEKQVYMSLPRPGKHGTTSKPLKPVRLDSEEQAKIAKAGLEMKLITSEMDAETEKWQESGNSQLEENNDIVKRAKNMSSMAFSMYQFTRGEGALKTTQDLFTQAEYFAEEANRLYKVVRQFSYQVPGGPNKKDLLENLDRVPTYVQQLQFTVKNPTVGKAATFTKVDNVIQETKNLMNIISKVVTTCFECATKYNLDFRGLSARGSGGSPYRGGDNSGDGDGTGVGADGSKSGSAPGSDPSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HRV0</accession>
    <name>A0A8J2HRV0_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Similar to sup-9: Two pore potassium channel protein sup-9 (Caenorhabditis elegans)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">HICCMSTLAB_LOCUS12106</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5106118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HRV0"/>
    <dbReference type="OrthoDB" id="297496at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015271">
        <property type="term" value="F:outward rectifier potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022841">
        <property type="term" value="F:potassium ion leak channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030322">
        <property type="term" value="P:stabilization of membrane potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000090">
        <property type="entry name" value="two pore potassium channel protein sup-9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003280">
        <property type="entry name" value="2pore_dom_K_chnl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003092">
        <property type="entry name" value="2pore_dom_K_chnl_TASK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013099">
        <property type="entry name" value="K_chnl_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003:SF326">
        <property type="entry name" value="ACID-SENSITIVE TWO PORE DOMAIN K+ CHANNEL DTASK-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003">
        <property type="entry name" value="POTASSIUM CHANNEL, SUBFAMILY K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07885">
        <property type="entry name" value="Ion_trans_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038061">
        <property type="entry name" value="K_channel_subfamily_K_type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01333">
        <property type="entry name" value="2POREKCHANEL"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01095">
        <property type="entry name" value="TASKCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 13 16" id="KW-0407">Ion channel</keyword>
    <keyword evidence="9 12 13" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10 12 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 12" id="KW-0630">Potassium</keyword>
    <keyword evidence="6 12" id="KW-0631">Potassium channel</keyword>
    <keyword evidence="4 12" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 12 13" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="9"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="78"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="108"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="157"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="190"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="220"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel" evidence="15">
        <location>
            <begin position="75"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel" evidence="15">
        <location>
            <begin position="169"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR038061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF07885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CAG5106118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="367" mass="41115" checksum="410AD9A0A340B829" modified="2022-05-25" version="1">MKKQNVRTLSLIVCTFTYLLIGAAVFDSLESETEKLRKEALDAIERMVKRKYNISEDDFKIMETVVLKTEPHKAGQQWKFAGAFYYAITVLTTIGYGHSTPNTISGKLFTMCYAMIGIPLGLVMFQSIGERLNKFSSVVIRRVKQLLNCKDVQASEINLIFVVTFLSSLTITCGAAAFSQYEGWTYFDSLYYCFITLTTIGFGDMVALQKDNALDNKPEYVIFALIFILFGLAIVAASLNLLVLRFVTMNTEDERRDEAEALQAAQGAVRLEGDVITANGSILSGQMGNQGDTISLVDDASVCSCRCTGFYRKQRRPRFTVRRSPGKISHLLPMQQFPASNFRDDIRPPPLTPLLHVPPIYQHRASI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HS05</accession>
    <name>A0A8J2HS05_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CCDC92/74 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS13365</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5108694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HS05"/>
    <dbReference type="OrthoDB" id="2155209at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039496">
        <property type="entry name" value="CCDC92/74_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14916">
        <property type="entry name" value="CCDC92"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CCDC92/74 N-terminal" evidence="2">
        <location>
            <begin position="48"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="17"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5108694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="99" mass="11300" checksum="45BACC48D01886A7" modified="2022-05-25" version="1">MTSKVLVKLPTVPFSQGKKSTPELMSLPARNDGVATPLRSQQTPGNGDRTAQLEQNMKFLQEQHQATLVALHQEVETLRQRNRGTENFYLYFFYDTEIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HSD3</accession>
    <name>A0A8J2HSD3_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Similar to Rgp1: RAB6A-GEF complex partner protein 2 (Mus musculus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS12408</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5106735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HSD3"/>
    <dbReference type="OrthoDB" id="1918at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014848">
        <property type="entry name" value="Rgp1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12507">
        <property type="entry name" value="REDUCED GROWTH PHENOTYPE 1 RGP1, YEAST -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08737">
        <property type="entry name" value="Rgp1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5106735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="360" mass="40671" checksum="AA30716B28955B26" modified="2022-05-25" version="1">MIEVIGRLLKGPVYFSGEVIECYVTFSNPLNPIHQKSQSYNDVFEGLAWASAQLHCQCSANDKIVITDKINSSRTSAINAETAFAPWQKDNGHAVVNTKPKILFCDLRLSPGESKTYIYRETIPSDAPPSYRGQAIKYSYKITVGAQRVNSPIKLLRIPFRVLSLSELPEVAICNDSVDLSPNNPFMDTQERENPLEISLQTLQNLTARRSPNFYNITNGRGKVVRFCLFKNSYKLGEDIVGTFDFSNATVSCVQVSVALQSEEHIADEYKRGKGNPSRMSYNKHHEVCLGLKYSQLVLPIPLHVTPDFFTHLMTLKWRLHFEFVTTTKVIEMPMANTIDWKAPSSLDVETMVNRIIIDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HSW0</accession>
    <name>A0A8J2HSW0_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Similar to NOP14: Nucleolar protein 14 (Homo sapiens)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HICCMSTLAB_LOCUS12725</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Involved in nucleolar processing of pre-18S ribosomal RNA. Has a role in the nuclear export of 40S pre-ribosomal subunit to the cytoplasm.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NOP14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5107390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HSW0"/>
    <dbReference type="OrthoDB" id="441771at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030692">
        <property type="term" value="C:Noc4p-Nop14p complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007276">
        <property type="entry name" value="Nop14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23183">
        <property type="entry name" value="NOP14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23183:SF0">
        <property type="entry name" value="NUCLEOLAR PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04147">
        <property type="entry name" value="Nop14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="4" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="133"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="193"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="290"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="15"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="133"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="143"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="208"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="231"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="307"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="352"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="392"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="418"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG5107390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="896" mass="103674" checksum="6393807B80A121D8" modified="2022-05-25" version="1">MAKTKNKKKNMAELASKKKMMDLQNKKKINPFEVHINRDKHKVLGKKLKSDRGLPGVARSKAINKRKHTLLVEFQQKDKNNLTIDSRIGERDRGMSQEDKAMARFTAEKLKLQKKNIFNLNDDEVLTHRGQTLEEIEKFEDPRSDDDDDDDDGRNSKGYLDKKFVNEAHFGGGMLSRSGESISRSDLISQLVNESKKRKAEKQRLSEQNRSQTEQLDSQWKDLLPLLAASKKTDEERVNKPRPDDFDRTVQELRFESRGNPSDRLKNQDEIVRQEREKLEALERDRLERMQGFADYESEGNNHRSVDDDDDGFEIEDITSDMLAYDKDGQIVDSFFKSMPEDDKKNKVNGTVDDDDDDDDDDDGDDDDDDDDNDDNEDEEDDLSDLKASDSSSEDEEEEEEEEEEEKENGKIPPKLNKSLDKSNGKVEKITNGETKELPANKLNSSTNEVKKDATREKLMEKVRQELPHTYPAPESYEELNELLRAQSPDHQSVILERIIKCNHISLGENNREKLTNVFEFLLQYLMDIARVKDVVRCFQICDRLVPYLYDLAQFNSKHAGSCVKVVLKEKFQEFKEKEKIYPKLDTLILFKVISLLFTTSDFHHAIVTPCFLFMSEILTRCKVKTAMDISMGLFIVTLILEFTLLSKRFLPAAINFLRGVVFLATIKPLSIPKIFSPFKQTGELSNLLILEKSQKDLELDVNGAHMKVNDLATREFDDDYRVRIFITTINLISQFKSQLEEIDIAYIIFKPIIELLDIGTNPWNNYPKSVKKHVQKVSDDLKSLANNKLNYLVFEKKRPKPFKFLKPLVTVVSDVKRFKAKSSREDKAEQEKLSLKLKKETKGAIRELKRDAAFLAKVQIKDQIKSDQERKRKVREIFGEAATQQGELNKMQRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HT13</accession>
    <name>A0A8J2HT13_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to APLF: Aprataxin and PNK-like factor (Homo sapiens)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS12814</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5107579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HT13"/>
    <dbReference type="OrthoDB" id="10256774at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003906">
        <property type="term" value="F:DNA-(apurinic or apyrimidinic site) endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006302">
        <property type="term" value="P:double-strand break repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039253">
        <property type="entry name" value="APLF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019406">
        <property type="entry name" value="APLF_PBZ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21315:SF2">
        <property type="entry name" value="APRATAXIN AND PNK-LIKE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21315">
        <property type="entry name" value="APRATAXIN AND PNK-LIKE FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10283">
        <property type="entry name" value="zf-CCHH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PBZ-type" evidence="2">
        <location>
            <begin position="146"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="PBZ-type" evidence="2">
        <location>
            <begin position="180"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="116"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="209"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="49"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="128"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="227"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5107579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="267" mass="30062" checksum="5E3ACEDC8BABA9B2" modified="2022-05-25" version="1">MDKKNSDGKRKSRSSNEGPPDKKSRIDIEDILLPCEDRNNDLSSHSIQNVVESSNSSKVELIKSSNDPSTSKEIHQSTSVEEATGIRVPAVNTEDKLIECTILVDTVEKKIKWNDKKNSTSKDASGDSVKNSQTPQTSTKTPAAPRAKCTFGAKCFRLNSEHKVKYSHPGDADFDVKDNRPECRHGIHCYRKNSQHKKDYQHTLVRRKRKVNANQVQVLKKGKDDDSDRDSDDSSFEESVDESEYGPSDLDESSEEENDVEDDDSDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HUI7</accession>
    <name>A0A8J2HUI7_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS13952</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5109316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HUI7"/>
    <dbReference type="OrthoDB" id="7698743at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21301">
        <property type="entry name" value="REVERSE TRANSCRIPTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21301:SF10">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5109316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="188" mass="21477" checksum="A3A3920AE2DA4CF4" modified="2022-05-25" version="1">MKDSYQFVERIKSVLVDDDYLLISLDVVSLFTNVKQDLIITIIKERWNVIKDFINLDQDLLLDLVKFCFHSGYFLFQRNYYIQKEGCGMGSPASPVIAITAVDYVISKALEKAIRLSHVNMVAVSTGKVKHLLMNNNYPSSLLRKCEKITNDRINSNLRIEAGLRGWSFCKFPYIEGLDACSGRLIVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MFT2</accession>
    <name>A0A8J2MFT2_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HICCMSTLAB_LOCUS2576</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the NIP3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001117">
        <property type="protein sequence ID" value="CAG5077859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MFT2"/>
    <dbReference type="OrthoDB" id="5857140at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097345">
        <property type="term" value="P:mitochondrial outer membrane permeabilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043065">
        <property type="term" value="P:positive regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010548">
        <property type="entry name" value="BNIP3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15186:SF5">
        <property type="entry name" value="BNIP3, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15186">
        <property type="entry name" value="RE48077P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06553">
        <property type="entry name" value="BNIP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="147"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="46"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="53"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="63"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAG5077859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="182" mass="20476" checksum="BC3E07E8874AE192" modified="2022-05-25" version="1">MSTSKYTLDESLGESWVELNPAQLADRITPLPFGSGGEEYLRLLREAQRDSTHSSARHSLASSRRDTPRDSPKSPPNSPNTERSTDDDLKGVYINYSCAKLKLMSRGAFISIDRDWKFKHPLGMTKRKTYSIRTAKVGKNGLFSKEVLYTLFLSNLLSLIIGTGFGVWLTRRGLMMTRVAIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MGA8</accession>
    <name>A0A8J2MGA8_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS2639</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001117">
        <property type="protein sequence ID" value="CAG5078086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MGA8"/>
    <dbReference type="OrthoDB" id="7685400at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5078086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="91" mass="10544" checksum="44D668A7C77EF4D9" modified="2022-05-25" version="1">MDHWALRFLPRKVNTKYGPKILGIVESEFSIFFPNRTNRMLIDDEEQLTSLIDLASAGELYLNYFGTAYHNYKYSEDELDSPPIEAALIIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MJ33</accession>
    <name>A0A8J2MJ33_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HICCMSTLAB_LOCUS5080</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9 15">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 15">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5089039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000010">
        <property type="entry name" value="Serine/threonine-protein kinase WNK1 isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056865">
        <property type="entry name" value="CCTL2_WNK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024678">
        <property type="entry name" value="Kinase_OSR1/WNK_CCT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050588">
        <property type="entry name" value="WNK_Ser-Thr_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13902">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE WNK WITH NO LYSINE -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24889">
        <property type="entry name" value="CCTL2_WNK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12202">
        <property type="entry name" value="OSR1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="658"/>
            <end position="970"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="87"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="123"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="206"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="319"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="570"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1053"/>
            <end position="1089"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1177"/>
            <end position="1196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1259"/>
            <end position="1371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1623"/>
            <end position="1643"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1768"/>
            <end position="1787"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1981"/>
            <end position="2028"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="2082"/>
            <end position="2130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="2208"/>
            <end position="2227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="2279"/>
            <end position="2325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="2388"/>
            <end position="2421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="2739"/>
            <end position="2781"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="2509"/>
            <end position="2536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="129"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="212"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="236"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="253"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="361"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="401"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="453"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="471"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="570"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="581"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1053"/>
            <end position="1065"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1259"/>
            <end position="1292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1303"/>
            <end position="1332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1355"/>
            <end position="1364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1623"/>
            <end position="1636"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1981"/>
            <end position="2027"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="2082"/>
            <end position="2091"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="2099"/>
            <end position="2110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="2111"/>
            <end position="2124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="2279"/>
            <end position="2309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="2739"/>
            <end position="2753"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="2770"/>
            <end position="2781"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAG5089039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="2781" mass="309315" checksum="DC4C888FFB9E0D22" modified="2022-05-25" version="1">MPRCCNENKIVSPVSTNNKVETNTENILLTSTRAYPIGNSNTVDFDDDSNHPIVEKSHRKLRCDLSPVPTNSSSRLNIKLLNLKTERGHRQEHCQTGTGGGGCRGREKDSKKRAAIGNVVRGLFPSGHSRQDRYEASRQRASGGASVGLSGLCPKLVASGAGSSQGGIGLGVGHIASQETGGTCGIVNAQKTHNSHHNRRQRKLSIINQVGSNASSKSSSTNRSLTNSKKQHRNLSDSSVETASITSNGVLSGGSPSPKKKTNSNSISDASCSLQNSQLISRDYSSGDTACSDAEEVVEIMSRVSGIDSVSILPAVKGKSNKLKDNDNNKTVDNNPLVETDSAYNDDNNGFKKSLHETQDAPENSKTIPASSKKLSQKSLDVDYSNQVKKRSMMRSSSHPRSMDSMDKHQSPSGTKSEERSRKTSKDSGVDSGERKKNSNDSVSQIPKRKISTESTDNCDSNIRKNSTKTINNDSENDIISSSDSSEKTKLEKIKNTRFVTSKVTEESTIVENRETEMTANIEEDNNQVTIYEDDNSTSISDIVAAQALRESLSKLGKVITFDAEQDFQSNNKSQSFSENDPPKEAETKDQVQVQEETVEGFIGPLLDENFKADEKLEKQKTMAMEDVRNLLMKVKVQTVEDKDEEKAIGMSPDERFLKFEEEIGRGSFKTVYRGLDTQTGVSVAWCELQEKKLNKSERMRFREEAEMLKGLQHPNIVRFYDYWEVTLTKRKYIVLVTELMTSGTLKTVEFRLRVLDPKKRTNKHKENEAIQFDFDIQRDNAEEVALEMAKSIPAQMQSAMQMNHPQQQQVIRQGQTHIQYTQTQMQQQLQKIHPNAVNSAPMLQQNVQQYYQQGNTSTAAFTNATLYQQQIYQSYPNNSNAAGHIEILQSGHNAQAIYSNTNVPSNVVIPTGQNFVSTSGQPGQIVIQSTPNVQNSPAIQNVHQQNLQASPCANIQNTSVLQSQQQNMLVQMQYTQNVNAIPANMNIIQNNSSATQSTNIQHQSQLINATEIYNNAEKSVLNKQDTVESVLSVTSDGPLSLQQEQLQSIAQNPVSSGQLPSSSDGHQESTEGTVPSEKSRVKRSGTKRRKTGIKLTVLSVTNSDGSSMTVECQLDTSKQKTVVFKFDRNDMVPLDIANNLVAENLLPQSQCDTFVELIEDIVKQLRLDPTRSLPLVAHGPADQSAGGSPVTSRRPRAREYNLDAVKRDETTNSGSSKILPIDQIISHIAATSMDNKPQQISTVNSIENLNIAATTTENSISDEISRRSSTSTQNTDTLTPVNIPSDSNDNCETIVGEDIPLDSTNISMEDSNDTQKLSGIESNSQNDPTNSKVDDETVPEIATLNQSNRKLESQDSSCESSQEGFLEPKKSVPMRKISRFLVSPVVEQKSISSESDTVTVCENVLKLPQQLSRLNLENSFANTEEGSNLNDMDNNSSEVSYAKQLQLAQQSQQSQQIQNMNQVQMGVQQMMGQMLPKGVVTQTKQETVVLVQTTNLAQQTNPQLLQNVQFQPTASGVQQQEQPLTQYQTQVTVQQHSVIQHQHQQQVGIQQQNIVQQHIQDQISVGQVQHQIPQQFIQQTLSQPAVQKPQPQAASHPYVLMQPLPQQIQQNNVEEWLCRGSSVSSDSHTSETPSVTQLHQPDHNQIGTADQQYQNVHQNLQNVNLSTPMQMSAQTVEVTPKVKAKEVSSTLPDLAQNLANILSNPKKSTTPHNIISHDQLNATAANQHQSIPVLHSEQYFQPIQPEMPQMNMQTYVQLQNFQGQPQQQGIHAQAQNQQEVQQSNYSQIQNQNEVQQQQQQQPQQQVYHQQIQSQADVQQQQQQQQQIYLSQIQNQVDVQQQYHSQIQSQTDIQQQQQQQQQQQQQTYHSQIQNQAEVQQQVYHQQIQNQTDIQQQQAYSQIQNQSDIQQQQQQQQQAYSQIQNQTDVQQHQVYNTQIQNQTEVKQHVYHTQIQNQTDVQQSYHSQIQNQSELLQQQQQQQQQQQPQIYHSHQQQPIQSVAQQQQQQQQPQPQQQQSQPPMQQMNQQIDLQSQVVTQTIQGHSQNFTVQGQWVMPPYSGHNVAQSAPMQYVQQPIQNLQPVAQIQSQSQEQDNLKFPESDNTVDGSVSRRTSSDYHTLSEHENSSYEITPEHTMLVESADLGSNSHYYFPQQQQHKLSQQNSLDKLSETANNSSGTCGPHTIADLHQKLVQLTSQPCDTLNIGTPPISHPATPHGQSNNLCYETPTAGHHLPQKTSVNIPTSVHSIGFVSPQTTVHSPGTIYIDANVTNTFDNNQSDQTMSQFVQSNTESALDSPTLNQTSNAETMSPSKESKSRSQRSGSRFQELEHELSKIHHRGLVLSTSSPQPITPPVPASNTQQIVNQLPSQSVTQTLLTPVIPVSSVAKTTPCVTGTPGTETPGQVDTPGQDTSEQKASSSQPTRKISRFMVSKVVGPPGTGEILSQTQLEQKQVQLQDDKRERTHTIHHMDDIQNAVQVIHSRENSIPPISSSTPSITEIEKEERIQLLTPSEEYQMLIKRQTLELETLQKKHREELELFQQQQLQLLIQQQQQASALHQHQHQPLLYHTVASTVTGSSRPLAVEDYLMFSTAPQTSFHRISNYSQDTEETLRLATQKLKQAPQQHTGIPHTYVIPIPIMPSADNIQNVPNYTSEPEIIGSTNGPTTVSSHPQYQLTSILSDGSIGSGPSGSLVASSAIPTASGPSYIHYHDPKTLANFQAFSYTPHSGFFLPAGYRLIYAPTGTPQSQPTTPATPHIGNSHDGTPPGEPQSEHTQSSTSQLEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MJP3</accession>
    <name>A0A8J2MJP3_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS5609</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5090382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MJP3"/>
    <dbReference type="OrthoDB" id="8193468at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31025">
        <property type="entry name" value="SI:CH211-196P9.1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31025:SF9">
        <property type="entry name" value="SI:DKEY-286J15.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5090382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="782" mass="89637" checksum="04BA7EFCF181DA12" modified="2022-05-25" version="1">MEEYKDLTVEGLINKLKGTIHDDETLEKLRHIIDECEELLVNTCGLLKDTVNNFLIEQGLINNDAAKDVLKTFDLTNVFDGLRRFDDQIAALESSCAYIRPVEIPLGHRMDKKLNRTSGTYEPTLDHRLINSVVCVCIRDDLHAGSLQLGQKRTLNLYQEHLDLLKNSNFSAENVSSTGMRGNCCLNESGYFHVTSNKIFDPMHDFLCGICPMIIKLVLKQYILVEKKFNTNYLNDVQLFRLQAFSRKEEFVENTLSRQFLLELNYTLNNKVLLARSVKVNGVEFCLGLYVCLEVPIVRSDTLPLFGKIKEIIILNGTEVHFLISTCITVEFNVNLHAYHLECNEESDNQKCIDGTVFLELKKEDLELMGIKMGPKILLLKVLGNLRATDSVIEKENNREFTSSSNIITPSSGNYPSAAGRSIERASTSFDVGATPKFSVQIYLFNVIYLQYLSNRTFNSFWYILEIWHGNSDIRSKDWFGGLQILKALRSSKIFEDVNRKALVRIVTSELVDYHQSHYPPQSAKLALAKALITEFPRLKNEYSKDGWYDENQVESIKKKYIKAALKKSEVLSSSSQSADYQFTSEEIDKKISLLKFIKPSDENKGKIITYMQETREFRWHWIQSASPTISEVFTTYPRLLDYDGEIIERDFDNKYPNVADNFLEKFATYYVPRINFFVKNCKPVLYTEAADITDENLRALIMLSALLPVSNSVITKRGKGVGKGKKRKLNESDDSPLPVKTTFLNKDLIKTLPGRERYQNFRKIEKGQCQKWSIWHGSSAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MKZ3</accession>
    <name>A0A8J2MKZ3_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Similar to mpv17l: Mpv17-like protein (Xenopus laevis)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HICCMSTLAB_LOCUS5822</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the peroxisomal membrane protein PXMP2/4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5090970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MKZ3"/>
    <dbReference type="OrthoDB" id="430207at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007248">
        <property type="entry name" value="Mpv17_PMP22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11266:SF75">
        <property type="entry name" value="IP10007P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11266">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN 2, PXMP2 MPV17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04117">
        <property type="entry name" value="Mpv17_PMP22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="32"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="67"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="109"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="174"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="179"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG5090970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="206" mass="23343" checksum="E7521A5921FB7A80" modified="2022-05-25" version="1">MASYTVIWPTACLLQQKISGKEKLDYIHALRFSLYGGFFVGPTLFAWLKIATYLWPKPNLRSAITKALVEQVTYGPAAICCFFFGINLLEFKPISECVEEVKNKFFPTWRIGVFVWPILQTINYVFIPERNRVVYVSFCSLGWTSLLSYVKSLETSQLNSGTVLMKEPKVLVPAVTDDNNNNNNNNNNSSKNQTTESTKKKSTSLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MLW8</accession>
    <name>A0A8J2MLW8_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="20">Similar to ck: Myosin-VIIa (Aedes aegypti)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">HICCMSTLAB_LOCUS7517</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5095054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6108017at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045177">
        <property type="term" value="C:apical part of cell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005902">
        <property type="term" value="C:microvillus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016461">
        <property type="term" value="C:unconventional myosin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003774">
        <property type="term" value="F:cytoskeletal motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009887">
        <property type="term" value="P:animal organ morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030182">
        <property type="term" value="P:neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009888">
        <property type="term" value="P:tissue development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd17092">
        <property type="entry name" value="FERM1_F1_Myosin-VII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17093">
        <property type="entry name" value="FERM2_F1_Myosin-VII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14473">
        <property type="entry name" value="FERM_B-lobe"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd13198">
        <property type="entry name" value="FERM_C1_MyoVII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13199">
        <property type="entry name" value="FERM_C2_MyoVII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd23767">
        <property type="entry name" value="IQCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01381">
        <property type="entry name" value="MYSc_Myo7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.820:FF:000001">
        <property type="entry name" value="Myosin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.720:FF:000019">
        <property type="entry name" value="myosin-VIIa isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.80.10:FF:000013">
        <property type="entry name" value="Unconventional myosin-VIIa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000075">
        <property type="entry name" value="unconventional myosin-VIIa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000079">
        <property type="entry name" value="unconventional myosin-VIIa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000036">
        <property type="entry name" value="Unconventional myosin-VIIa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000051">
        <property type="entry name" value="Unconventional myosin-VIIa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.190">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.80.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.240.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.720">
        <property type="entry name" value="Myosin VI head, motor domain, U50 subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.530">
        <property type="entry name" value="MyTH4 domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019749">
        <property type="entry name" value="Band_41_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014352">
        <property type="entry name" value="FERM/acyl-CoA-bd_prot_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035963">
        <property type="entry name" value="FERM_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019748">
        <property type="entry name" value="FERM_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000299">
        <property type="entry name" value="FERM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000048">
        <property type="entry name" value="IQ_motif_EF-hand-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002404">
        <property type="entry name" value="IRS_PTB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001609">
        <property type="entry name" value="Myosin_head_motor_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057130">
        <property type="entry name" value="Myosin_VII_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041793">
        <property type="entry name" value="MyoVII_FERM_C1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041794">
        <property type="entry name" value="MyoVII_FERM_C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036106">
        <property type="entry name" value="MYSc_Myo7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000857">
        <property type="entry name" value="MyTH4_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038185">
        <property type="entry name" value="MyTH4_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051567">
        <property type="entry name" value="Unconventional_Myosin_ATPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22692:SF33">
        <property type="entry name" value="MYOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22692">
        <property type="entry name" value="MYOSIN VII, XV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21998">
        <property type="entry name" value="FERM_C1_MyoVII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00612">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02174">
        <property type="entry name" value="IRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00063">
        <property type="entry name" value="Myosin_head"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24123">
        <property type="entry name" value="Myosin_VII_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00784">
        <property type="entry name" value="MyTH4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21989">
        <property type="entry name" value="RA_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07653">
        <property type="entry name" value="SH3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00193">
        <property type="entry name" value="MYOSINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00295">
        <property type="entry name" value="B41"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00015">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00242">
        <property type="entry name" value="MYSc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00139">
        <property type="entry name" value="MyTH4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47031">
        <property type="entry name" value="Second domain of FERM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50057">
        <property type="entry name" value="FERM_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51456">
        <property type="entry name" value="MYOSIN_MOTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51016">
        <property type="entry name" value="MYTH4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 13" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="7 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10 13" id="KW-0505">Motor protein</keyword>
    <keyword evidence="9 13" id="KW-0518">Myosin</keyword>
    <keyword evidence="6 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 12" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="Myosin motor" evidence="19">
        <location>
            <begin position="57"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="domain" description="MyTH4" evidence="18">
        <location>
            <begin position="1000"/>
            <end position="1235"/>
        </location>
    </feature>
    <feature type="domain" description="FERM" evidence="17">
        <location>
            <begin position="1240"/>
            <end position="1550"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="16">
        <location>
            <begin position="1548"/>
            <end position="1620"/>
        </location>
    </feature>
    <feature type="domain" description="MyTH4" evidence="18">
        <location>
            <begin position="1696"/>
            <end position="1844"/>
        </location>
    </feature>
    <feature type="domain" description="FERM" evidence="17">
        <location>
            <begin position="1850"/>
            <end position="2123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Actin-binding" evidence="13">
        <location>
            <begin position="606"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="936"/>
            <end position="963"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="853"/>
            <end position="909"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="150"/>
            <end position="157"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="20">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="CAG5095054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="2123" mass="246077" checksum="F25A602AE35A867E" modified="2022-05-25" version="1" fragment="single">GDYIWIEPISGREFDVAIGARVISAEGRRIQVKDDDNKEQWLTPERRIKAMHATSVQGVEDMISLGDLHEAGILRNLLIRYNENLIYTYTGSILVAVNPYQILPIYTAEQIKLYKDRKIGELPPHIFAIGDNSYAHMNRYGQDQCIVISGESGAGKTESTKLILQYLAAISGKHSWIEQQILEANPILEAFGNAKTVRNDNSSRFGKYIDIHFNHQGVIEGAKIEQYLLEKSRIVSQNRDERNYHVFYCMLAGLSKEEKKRLELEDASQYRYLTGGGSITCEGRDDAAEFADIRSAMKVLLFSDNEIWEILKLLAALLHMGNIKYRATVIDNLDATEISEHTSVQRVAQLLGVPVQSLVAALTRRTIFAHGETVISTLSREQSVDIRDAFVKGIYGRLFVHIVKRINEAIYRPKNTSRSAIGVLDIFGFENFDHNSFEQFCINYANENLQQFFVQHIFKLEQEEYNHEGINWQHIEFVDNQDALDLIAIKQLNIMALIDEESKFPKGTDQTMLAKIHKTHGSHRNYLKPKSDINTSFGLNHFAGVVFYDTRSFLEKNRDTFSADLLQLIHISSNKFLQTCFAEDIGMGSETRKRAPTLSTQFKKSLDSLMRTLCSCQPFFIRCIKPNEFKKPMMFDRGLCCRQLRYSGMMETIRIRRAGYPIRHSFPEFVERYRFLLSGIPPSHKTDCLAATTRICRQVLGQSDYQLGHTKVFLKDAHDLFLEQERDRVLTRKILILQRNIRGWVYRRRFLRMRAAAIVVQKMWRGYEQRQRYKRMRSGYMRLQALIRSRVLAHRFRHLRGHIVALQARARGYLVRRMYRKKMWAIVKIQAHVRRLIAQRRYKKVQYEYRLHIEALRLRKKEERELKDQGNKRAKEIAEQNYRERIQELERKEIEMEMEDRRRMEIKKNLINDAAKKQDEPVDDSKLVEAMFDFLPDSSSEAPTPARETSVFNDLPSPKADQQEIISPVQTASEDEEDLTEFKFQKFAATYFQGNITHHFSKKPLKHPLLPLQTQGDQLAAQALWITILRFTGDLPEPRYHTMNRDTTSVMSKVTATLGRNFIRSKEFQEAQMMGMDPESFKQKPRSIRHKLVSLTLKRKNKLGEDVRRRLQDDEYTADSYQSWLESRPTSNLEKLHFIIGHGILRAELRDEIYCQICKLLTNNPTKSSHARGWILLSLCVGCFAPSEKFVNYLRAFIREGPPGYAPYCEDRLKRTFNNGTRNQPPSWLELQATKSKKPIMLPITFMDGNTKTLLADSATTARELCNQLSDKISLRDQFGFSLYIALFDKVSSLGSGGDHVMDAISQCEQYAKEQGAQERNAPWRLFFRKEIFAPWHEPTEDQVATNLIYQQVVRGVKFGEYRCDKEDDLAMIAAQQYYIEYHTDMNVDRLFALLTNYIPDYCLTSLEKPIEVWGHLVLQAYKKSYYLKEKVPALRVKEDIVGYAKFKWPLLFSRFYEAYRNSGPNLPKNDVIIAVNWTGVYVVDDQEQVLLELSFPEITTVSSQKTTKMFTQTFSLSTVRGEEFTFQSPNAEDIRDLVVYFLEGLKKRSKYVIALQDYKPPGNENNCSSFLTFQKGDLIVLDDESTGETVLNSGWCIGICERTGEKGDFPAETVYVLPSLSKPPNDILALFSIEAPENSRRLYPQQINGIEPRDKPHTLLEYSIDHFRTPPKRTMSKALTLTTARRGHVDELWRHSRDPIKAPLLKKLISKEELAEEACFAFNAILKYMGDLPTKRPRIGNEYTDLIFEGPLKNEILRDEIYCQIMKQLTDNRNRLSEERGWELMWLATGLFVCSQSLLKELTLFLRTRRHPISQDSLQRLQKTLRNGQRKYPPHQVEVEAIQHKTTQIFHKVYFPDDTDEAFEVDSSTKAKDFCQNIAQRLNLRSAEGFSLFVKIADKVISVPEGDFFFDFVRHLTDWIRKTRPSRDGVSPQFTYQVFFMKKLWTNTVPGKDRNADLIFHFHQELPKLLRGYHNCSKEEASRLAALVYRVRFGERMSPEDAKIQFLKAIYRWPTFGSAFFEVKQGTDPNYPELLLIAINKTGVSLIHPQTKEILVTHPFTRISNWSSGNTYFHMTIGNLVKGSKLLCETSLGYKMDDLLTSYISLMLTNMNKQRTIRGPKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MMP2</accession>
    <name>A0A8J2MMP2_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Similar to EGFL8: Epidermal growth factor-like protein 8 (Sus scrofa)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HICCMSTLAB_LOCUS9058</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5099427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MMP2"/>
    <dbReference type="OrthoDB" id="6516201at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005102">
        <property type="term" value="F:signaling receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000010">
        <property type="entry name" value="Pro-epidermal growth factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050969">
        <property type="entry name" value="Dev_Signal_Modulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000152">
        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018097">
        <property type="entry name" value="EGF_Ca-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049883">
        <property type="entry name" value="NOTCH1_EGF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14949:SF56">
        <property type="entry name" value="EGF-LIKE-DOMAIN, MULTIPLE 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14949">
        <property type="entry name" value="EGF-LIKE-DOMAIN, MULTIPLE 7, 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07645">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00010">
        <property type="entry name" value="ASX_HYDROXYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01187">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1 6" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="EGF-like" evidence="8">
        <location>
            <begin position="300"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="8">
        <location>
            <begin position="334"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="138"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="8"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="138"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="170"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="304"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="322"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="338"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAG5099427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="524" mass="59659" checksum="34C917D998C5DBC2" modified="2022-05-25" version="1">MSNNRIRKDSKKKKKKKKKKKKTKKRRKGEKKRTIGELMQESKRGLLWWGRITNNQQLKHVESKVLKMINNNSVGMTGVSLLILVEVISYLGTNPAGLEFPFNQNYNFHDDDDDNNNTRGSEIGSFDHDWMNLHRHQTRSNYHRHQHNSTAKLAPSHNHHQHNASIDRNSPSSSSSSSSSSSVYHLREYDNNINNNGKTVVSGSEKFTAVAVAEYSGTRAVAYAGYNNNNQDQYALHTTTPVPSYTRHHSGRRVCTRTPSVNHHYSSRQIRFVYTQVSAASSFICCPGWSQVTQTSYGCNRPTCVAPCHNGGVCGPHGKCNCPKGFAGSQCQLDIDECMTEKPCAQICKNLPGSYECHCRYGFQLQPDGQSCKKNDSDGTAFEARDLENDYGIVTTTRRPIIPSPRDTENEVSDGDASRDYEVILKRLTKLEKQFSRGKRRESEAAELNGRVNQAVEGVAELRLAAKNVLHFLRETFEPVRQQVYEMKNKFELERRRIDYIVQRFTEIDHQLNQHKNQRTDING</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MNP0</accession>
    <name>A0A8J2MNP0_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Adenosine deaminase-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HICCMSTLAB_LOCUS7331</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the hydrolysis of the free cytosolic methylated adenosine nucleotide N(6)-methyl-AMP (N6-mAMP) to produce inositol monophosphate (IMP) and methylamine. Is required for the catabolism of cytosolic N6-mAMP, which is derived from the degradation of mRNA containing N6-methylated adenine (m6A).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>N(6)-methyl-AMP + H2O + H(+) = IMP + methylamine</text>
            <dbReference type="Rhea" id="RHEA:16001"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="ChEBI" id="CHEBI:59338"/>
            <dbReference type="ChEBI" id="CHEBI:144842"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:16002"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5094005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MNP0"/>
    <dbReference type="OrthoDB" id="272271at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004000">
        <property type="term" value="F:adenosine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006154">
        <property type="term" value="P:adenosine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046103">
        <property type="term" value="P:inosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009117">
        <property type="term" value="P:nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00443">
        <property type="entry name" value="ADA_AMPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.140:FF:000033">
        <property type="entry name" value="Adenosine deaminase-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001365">
        <property type="entry name" value="A_deaminase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006330">
        <property type="entry name" value="Ado/ade_deaminase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11409">
        <property type="entry name" value="ADENOSINE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11409:SF42">
        <property type="entry name" value="ADENOSINE DEAMINASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00962">
        <property type="entry name" value="A_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Adenosine deaminase" evidence="11">
        <location>
            <begin position="9"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00057464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00070474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAG5094005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="336" mass="37979" checksum="330619D6BF30A681" modified="2022-05-25" version="1">MDLFCQKLPKLELHAHLNGSVSQKTIRKLSELNNKNFNDELSKIDSSVSLKECFKIFDIVHSLTNTIEALFITTCDVINEFNDDNVIYLELRSTPRYVEGKMTKNEYIDTIIKAIEHSKKTTPGITVKLLVSVNRKNGFKDAEENIKLAIEYYKKYPECLVGIDLSGDPTQGDACLNLLKSARDVGLKIAAHCAEVPNEKEVMDILDFKPDRLGHCTNIHPNLSGSLKLFNKLIESKIPVELCLTSNLKCKTVPSLSEHQFSYLYRANHPLCLATDDKGVFNTTLSQEYKLAADTFNLTKEDLKKLVRSSVDFAFISEQEKEKLLATIDNKLTNIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MNS7</accession>
    <name>A0A8J2MNS7_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS9089</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5099499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MNS7"/>
    <dbReference type="OrthoDB" id="6497308at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="110"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="157"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="193"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="482"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="696"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="206"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="482"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="701"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="871"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5099499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="871" mass="96140" checksum="B7A3C00BBA28A1EC" modified="2022-05-25" version="1" fragment="single">MPRKRTNLSSSKARARRKKIYMLRKKQEELKEEFKNLAGNDDNINELDDKLTDLDNLIDRNVNDEDDDGDDDDNDEDDNDSNIDGTCAINNNNNKQLDTEDIEIVSVVESIQESSQSKPARGTFDEVPVKQERPDEAEIRELAAKMVEANKAKVQSMPAPPVRPANNNNNNNLPGGQTGILGYLTRKPVEGTGAGAAAQPAAGKSPSKDQDGKVPLDDESQRGRFGWVSFEKVHIPYIFRGSEKYCAVRILEAKLLNKYLNYLHSDIYSCTCIKSYFITEAESKLLNEINNKHCENQFGKEQFTTRDLVVRLSDAREFYTFLDVCYTKLTSNNVIGNNSGNNNGHNKNDKCGFIRINKESVVPYTIKDNLKYVPLFYFEGETDNLKLKAEKLEGWDLSYLKFCCKVQGIRNELFASETCSVISLTDIKSYFPPGTGFEDYWPSKVMDSQLFVNGKSGASAGGWTKQPPAPPANIINKQLQNNSTGKSSAQLTSRSSAGLQNIPRNSPANATTLQPVNQSSRSAVTAHPAHVSSNSLSANARSTAANNNAQNMLGSLTTVNGWTGLVGGQPAFQTAIVPQSNAVIRMTNSALIHNAYQQPSRSRAGGNGTAVPGQYPSYPVTTIQTIPQAQPTLRATVHSNQPNLGVGSTYTTSSLTNPNIVTASTYPQMLNLSPDQVQALLHPQSTAASALLSHSQRHTPPAHNAHNNAHPKTAAYPPPLIPVNGNSNNARDSHGRKQLILIQDAPVSNTSHVQPYGIQKALVEEKLVPCINYKPYIYSELLMTLPDFVSQYFPACDINNCRQVITEVLDCELYQGNRQQMKKLMEAGKCSSLTDELPLIHVRKFVPARKALKSAHRMARWKIMPFLHIND</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MPN7</accession>
    <name>A0A8J2MPN7_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">N-acetylglucosaminylphosphatidylinositol deacetylase</fullName>
            <ecNumber evidence="2">3.5.1.89</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HICCMSTLAB_LOCUS10857</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PIGL family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.89" evidence="2"/>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5102122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MPN7"/>
    <dbReference type="OrthoDB" id="440160at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000225">
        <property type="term" value="F:N-acetylglucosaminylphosphatidylinositol deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10320">
        <property type="entry name" value="LmbE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003737">
        <property type="entry name" value="GlcNAc_PI_deacetylase-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024078">
        <property type="entry name" value="LmbE-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12993:SF11">
        <property type="entry name" value="N-ACETYLGLUCOSAMINYL-PHOSPHATIDYLINOSITOL DE-N-ACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12993">
        <property type="entry name" value="N-ACETYLGLUCOSAMINYL-PHOSPHATIDYLINOSITOL DE-N-ACETYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02585">
        <property type="entry name" value="PIG-L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102588">
        <property type="entry name" value="LmbE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="29"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG5102122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="287" mass="34041" checksum="F6D1BEC28BE985EB" modified="2022-05-25" version="1">MFDIKSPKRFIKEQINEIGQWWSWYIREITWQIIITLIAYLLVCILLYIILKRVNHQAWQLPGPPSKILFVTAHPDDEVMFFGPMIYWLSKFKTTNVYLLCFTNGGHRRRKEELWASAKIIGIPEANITIIINSELPDNPKVQWPGSIISENILHYIETYKMNAVVTFDKRGVSGHKNHISLYYAIASLCIEKKIPSYCKLYILESVNILRKYVQLLDLPISLLTSSYWYLVNYEQRRTIQSAMKAHKSQYVWFRKLYMTFSRYTFINTLQEVNALDLEFDLQYEDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MSL7</accession>
    <name>A0A8J2MSL7_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Similar to CRYL1: Lambda-crystallin homolog (Homo sapiens)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HICCMSTLAB_LOCUS12899</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 3-hydroxyacyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5107749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MSL7"/>
    <dbReference type="OrthoDB" id="2021159at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050104">
        <property type="term" value="F:L-gulonate 3-dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000356">
        <property type="entry name" value="Lambda-crystallin homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006180">
        <property type="entry name" value="3-OHacyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006176">
        <property type="entry name" value="3-OHacyl-CoA_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006108">
        <property type="entry name" value="3HC_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48075">
        <property type="entry name" value="3-HYDROXYACYL-COA DEHYDROGENASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48075:SF1">
        <property type="entry name" value="LAMBDA-CRYSTALLIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00725">
        <property type="entry name" value="3HCDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02737">
        <property type="entry name" value="3HCDH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00067">
        <property type="entry name" value="3HCDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3-hydroxyacyl-CoA dehydrogenase NAD binding" evidence="4">
        <location>
            <begin position="6"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="3-hydroxyacyl-CoA dehydrogenase C-terminal" evidence="3">
        <location>
            <begin position="190"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAG5107749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="316" mass="35464" checksum="A3087B5817B24F41" modified="2022-05-25" version="1">MAKNEKIGVIGSGLIGRSWAMLFASVGYQVTIYDILQEQISNALTDIEQQLKKLESEGLLRGNLTAKQQFELIKGSSSLPEIVKGAKLIQECIPEKLDLKKKLYGELDKLVDDKTILSSSTSTFKPSLFSENLKHRDQVIVSHPVNPPYYVPLIEIVPSPWTRPDIPEKTKAIMTEIGQSPVVFTREIDGFALNRIQYAILNEAWRLVTDGVISVKDIDIVMSEGLGMRYAFLGAFEAAHLNAEGMKKYCETYNKSIYDVSQTFGPTPKFVGAAAENISKQLEEICPLDKLQERRAWRDLALTKLSILKKELEKIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MSU3</accession>
    <name>A0A8J2MSU3_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Dual specificity protein phosphatase 15</fullName>
            <ecNumber evidence="4">3.1.3.16</ecNumber>
            <ecNumber evidence="3">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">HICCMSTLAB_LOCUS6823</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10684"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="EC" id="3.1.3.48"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="4"/>
    <dbReference type="EC" id="3.1.3.48" evidence="3"/>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5093433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MSU3"/>
    <dbReference type="OrthoDB" id="9979246at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14519">
        <property type="entry name" value="DSP_DUSP22_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.10:FF:000052">
        <property type="entry name" value="Dual specificity phosphatase 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000340">
        <property type="entry name" value="Dual-sp_phosphatase_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45948:SF2">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45948">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN PHOSPHATASE DDB_G0269404-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00782">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01908">
        <property type="entry name" value="ADSPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00195">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50054">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0519">Myristate</keyword>
    <keyword evidence="8" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="16">
        <location>
            <begin position="1"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="17">
        <location>
            <begin position="57"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="188"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="280"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="15">
        <location>
            <begin position="195"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="205"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="18">
        <location>
            <position position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00051722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00068799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="CAG5093433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="346" mass="37432" checksum="867474F3D72F2017" modified="2022-05-25" version="1" fragment="single">VLPGLYVGNYRDSKDEAQLKRFEITHILAIHDAARRLHSDKHYLCILAADTPDQNLTQYFSLCNDFIHAARLRGGNVLIHCLAGMSRSVTVAVAYIMSITNLSWKEALKVVRVGRAVANPNVGFQQQLQDFESTRLADERKRLRERFPSLALTASDAELCRATLRNYETLAMAREVCEGKCAMGRPCPSGMCRQPSKRTLRRKSSTSSTGSSGSGRTPPQTPRLLPSAPPSPALPRSASVISANIRPRSGPAGLHSYTGSAPPSRAVSRVDLSAAVACSSGSSLSLTTVGRTTPMAPTRSTNYHNRLSAGSAPVTPRTTPPISPQHWPRRQTPQLPVPPESSSSVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MTG1</accession>
    <name>A0A8J2MTG1_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Similar to Ttll4: Tubulin polyglutamylase TTLL4 (Mus musculus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HICCMSTLAB_LOCUS13478</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5108842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MTG1"/>
    <dbReference type="OrthoDB" id="202825at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015631">
        <property type="term" value="F:tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070740">
        <property type="term" value="F:tubulin-glutamic acid ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004344">
        <property type="entry name" value="TTL/TTLL_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12241:SF162">
        <property type="entry name" value="TUBULIN MONOGLUTAMYLASE TTLL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12241">
        <property type="entry name" value="TUBULIN POLYGLUTAMYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03133">
        <property type="entry name" value="TTL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51221">
        <property type="entry name" value="TTL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG5108842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="457" mass="53709" checksum="750D872E5BC15C6C" modified="2022-05-25" version="1">MNSGFRLLKNPDDWVAIWGKQMKSNCFKSLKDHQKFNHFPGTFQLGRKDRLWRNLSRFMSKYGKKEFNFVPRTYVLPQDLRNFRQVWEKSGGKEKWIIKPPASARGTGIRVVHRWSQIPKKRPLIVQQYLSKPLLIDGAKFDLRLYVLISSINPLRIYIYPDGLVRFASVKYSDDINYLSDRLMHLTNYSINKNSSNYTSNDCADSCSGHKWTIKTLWSYLEKKGVNTRKIWTSIKDIVIKTIISTESPINSLTKINTSNRYNCFELFGVDILLDESYKPWLLEFNVSPSLQSSSALDIAVKGPMIKNVFNIVGYRLPGSLPKREIKKLRSLYDYEDLVCQLPVLDKLVLSNEEKQKQNLYINLDREDYLDDILEDLTPDDLRCLIHHEDEITQTDKFERIFPAKHSSHYLDLFDVPRYYNMLIDAWENKYEDDRDEGITLLKKLCREMMHLESEAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MTJ8</accession>
    <name>A0A8J2MTJ8_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS12705</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5107350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MTJ8"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035147241" evidence="1">
        <location>
            <begin position="20"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5107350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="107" mass="11542" checksum="3217443AE09C5548" modified="2022-05-25" version="1">MLKFLCLTTVLCISVSVSQFDCTPISHIGREKPSCNRIAAVLATTLVGSLLGVQQMAKIQNVQWIPNALFIARKLRPTSVAKAAPTKIPLPTAVPLTFVGNNSPRRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MU85</accession>
    <name>A0A8J2MU85_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">tRNA (uracil(54)-C(5))-methyltransferase</fullName>
            <ecNumber evidence="4">2.1.1.35</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HICCMSTLAB_LOCUS13266</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>uridine(54) in tRNA + S-adenosyl-L-methionine = 5-methyluridine(54) in tRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:42712"/>
            <dbReference type="Rhea" id="RHEA-COMP:10167"/>
            <dbReference type="Rhea" id="RHEA-COMP:10193"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74447"/>
            <dbReference type="EC" id="2.1.1.35"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="5">
            <dbReference type="Rhea" id="RHEA:42713"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.35" evidence="4"/>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5108495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MU85"/>
    <dbReference type="OrthoDB" id="534815at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030697">
        <property type="term" value="F:tRNA (uracil(54)-C5)-methyltransferase activity, S-adenosyl methionine-dependent"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.1070">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030390">
        <property type="entry name" value="MeTrfase_TrmA_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045850">
        <property type="entry name" value="TRM2_met"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010280">
        <property type="entry name" value="U5_MeTrfase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046362">
        <property type="entry name" value="Zw10/DSL1_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048343">
        <property type="entry name" value="ZW10_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055148">
        <property type="entry name" value="ZW10_C_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048344">
        <property type="entry name" value="Zw10_middle"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45904">
        <property type="entry name" value="TRNA (URACIL-5-)-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45904:SF2">
        <property type="entry name" value="TRNA (URACIL-5-)-METHYLTRANSFERASE HOMOLOG A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05958">
        <property type="entry name" value="tRNA_U5-meth_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20666">
        <property type="entry name" value="ZW10_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22766">
        <property type="entry name" value="ZW10_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20665">
        <property type="entry name" value="Zw10_middle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51687">
        <property type="entry name" value="SAM_MT_RNA_M5U"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01230">
        <property type="entry name" value="TRMA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Centromere/kinetochore protein zw10 middle" evidence="8">
        <location>
            <begin position="676"/>
            <end position="888"/>
        </location>
    </feature>
    <feature type="domain" description="Centromere/kinetochore protein zw10 C-terminal" evidence="9">
        <location>
            <begin position="933"/>
            <end position="1064"/>
        </location>
    </feature>
    <feature type="domain" description="ZW10 C-terminal helical" evidence="10">
        <location>
            <begin position="1088"/>
            <end position="1232"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="531"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="6">
        <location>
            <position position="531"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="403"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="454"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="503"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00033763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00047278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF20666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF22766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAG5108495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="1233" mass="140405" checksum="9E3F8CCB8E1DCBD2" modified="2022-05-25" version="1">MTDAAEDCEEKLSNVEETDELNNPYAYLEREDFTSEKFKILVSGLPKYFGIKQVKKLFNEKLGLQTCKIKPLNNKLNWIFVNFRNEEAREHGLKTIDGMVWKNCQLTAKKAKAAPDPFIKRKLEADEKNCKKLKTNDEDNDQEQKEEIISVLDQIKSTTIPLWDVPYEKQLSMKHSEMRSIIAKLGQLIARNNSGLTGWIEKQRAVNDGLICELKPILSAEEINGYRNKCEFTIGKNEDNEILIGFRMSSYAAGSTTVGPIDHLCHIPERMKIAVRVFQKFVRESQLDVYDPVNHKGFWSQITVRATRLGHLMLIIGTYPKNLPVDISFDDLVAKIINFFEEGDGKEAQVTSLYIQMMGGSDSDGGNRPQERNGPIKHLSGSLHIEELLMGLKFRISPQAFFQINSQGAEILYQAAIDLAQCDKENTSLLDICCGTGTIGLCFAKHCAEVLGIEIVGDAIKDAKENAKQNNIDNCEFFVGKAESLLKAVIQRTIKENIIAVVDPPRAGLHHQAVLSLRKTKKVSKILYVSCDPKAAMSNLVDLARPVSKQYLGEPFVPIKAIPVDMFPNTKHCELIILLERLSSTASYSPDTLIACNSSLYLSAKLLELEQFTKSVDKLRQNKDYVEAARVLQKIIVLLTDEESHDDLQMLSIYSAIKENYQLTYRSLLSTVLKLWEEHVIWAASDDDKNSKTNNNDTSSVSLTIDCDPDEIKNIIQALHYLSELPLCLEHFSTKLMKLIIKPIISAECSVFVLDEKVFNVVTSNEKKELPSYKSILHNLKMLFQFIYQHLNVIIDDKMFISRLNEHLWTQLSEYLLNNCINDIIPSSSVELNNFKSIEDDIHEFEQYLGEIGFITQEQLVISNYIKDVDNLYIAKICQEFLVKASQLVKKNLHDSFKHDHHVNEKLERESDEIVNCTLINAQTERHLNKNTFILPACQISASARELLQLVHDILNEAVLNSENSTAASAKLYYTSRNVIEHYVWTVPEYHKKFLETIPQQVALFHNNCMYLAHNLMTLGHEYKAKLPKLKNHNITYVDLTLKLRNIGSQTFLNHVKYQRGIITDIIKDSGLSQLAQNQLPSSSGVERALRQCIRQLELLKTVWFNVLPINVYHKTLGCILNSMIEDLICKVTILEDISADAATELVNLFNMLVKRAPLIFSEENSVNRYVKKWQKMLELIKVLEASLKDIEKRWADGKGPLAREFSASQVKQLVRALFQNTERRSALLATIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MUB2</accession>
    <name>A0A8J2MUB2_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Similar to Npffr2: Neuropeptide FF receptor 2 (Mus musculus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HICCMSTLAB_LOCUS13326</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5108616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MUB2"/>
    <dbReference type="OrthoDB" id="10037617at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004983">
        <property type="term" value="F:neuropeptide Y receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14993">
        <property type="entry name" value="7tmA_CCKR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000611">
        <property type="entry name" value="NPY_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45695">
        <property type="entry name" value="LEUCOKININ RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45695:SF15">
        <property type="entry name" value="OPSIN RH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01012">
        <property type="entry name" value="NRPEPTIDEYR"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9 13" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 9 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="42"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="79"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="116"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="158"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="227"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="286"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="324"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="12">
        <location>
            <begin position="58"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="409"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="419"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAG5108616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="527" mass="59300" checksum="D945F1C166244EB6" modified="2022-05-25" version="1">MEVSLGEVISEREGNINSSLEIEKISELLDNFYKSLQNDADYFLISLYIPTIVVAVTANLIVITVVVKYQHMRSITNYFVVNLSIADLLVTLICMPMSVSQAISIIWNYGEIMCKLFYYLQGVAVAASVFTITAMSVDRYLAVRSPMDLHRMFNRKTTIMTIITLWFIALTIFAPLLKAVSLENLDLQLNLTLVVMAAENESLKILEPPSLLVCSEDFKPLGIHAHVFGTFCFVLVYAIPGFVVILAYSLMGRTLCARKPPFDYDCNAGSASSQQGFRLMRERKRVAWILLTLAILFALCWLPYNVLRLLVDLDVVYQDRVIPVLLPYCLYLGHANSALNPVVYCFMTRNFRQSVKQILCRRFGKSDKSKPNRKSAKGAGIILGSSIKQRGMRIQRAPREAGIVAEAKPATVRNVPERNATSSSGYDSSNNRHSPHRRCYKLKNLSTVKIVGRASATNCPPGKLLTKQEQYFTTSLNDVDFSNTNKINREDQGPRRSRSLQTLSTVTIHRQNTLESAVQVTQFINNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MUU2</accession>
    <name>A0A8J2MUU2_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS8349</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5096716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MUU2"/>
    <dbReference type="OrthoDB" id="7551505at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd03524">
        <property type="entry name" value="RPA2_OBF_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5096716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="269" mass="30728" checksum="83CB43D12E5BC463" modified="2022-05-25" version="1" fragment="single">FTSMLIEMKMSGEKVIFTPNSDIEKLTPKSKFQLVGYVDAIEATAKYGQKTAFKFVVNNGNGYRVQVYAWNDQVKRTEAVVKLDHIFYIDGGIGVANSEYNRGNYFGAQLSIQKYTTITDFGKLDRKLYSVSETNDNGELQTIELDAISNNLLPKKFRKYCRVYIKTKFTVLDSGNDDNQAFFYITNGTVRMSVTINLYEANNYNVGDHVILSGSVHKLKSDEECFIVESMNDIEIAGEDKKSINWLLQGNKIIYQENPFNSHKRQKIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MYL9</accession>
    <name>A0A8J2MYL9_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="2">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HICCMSTLAB_LOCUS13020</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="2"/>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5108003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MYL9"/>
    <dbReference type="OrthoDB" id="9984778at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16474">
        <property type="entry name" value="RING-H2_RNF111-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045191">
        <property type="entry name" value="MBR1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22937:SF65">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE ARK2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22937">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RNF165"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="10">
        <location>
            <begin position="617"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="162"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="223"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="316"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="26"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="162"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="241"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAG5108003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="673" mass="76808" checksum="F2309A7A63BA1A0A" modified="2022-05-25" version="1">MAEGKNTDEAWRKSKTGDRNDLFNPDATTSSEDSNSTSLADIFDTAFTSTVDPTPQRCPAVTEMEYEHLFAESDIEEADSQNRVDSFVNQPQHSTSSNNLVFASYRSSSTPITDSRYWRGVRVNNCNMCRTRSRRDPVTQPLDNMCDERLCAHYRRKRILYDRELPTKHKTKKNEPHKVDNNQQVSNLSIAGPSRLIDTPVDYSITGSANHIIDTIDDNSNKVTRQVTNERSSSQSSAASTQILPSVSHQTTSKDHDDIPSAPDLQLDWSSSSESDDEDGSIQVLETVNYSNKQNTNQDNEQSDRTVTVVDLTAESDDENHSHSTATNSTSPQAQEITSLRNNYCVHRPPEHPRIIPGGVPYHRYPYQGTRMHPMYQRMWYIQQRVQETQRRRLYQRSSVHTCTPPNAHMYQPGRFVTDENSSPSSLPQMCCAANDSGNHADNYPQHPVLPPPQQPTVYSHPEASGPESLVTNRTRIFPSSGLVNAMRNAEMEASPPDPMHPMPVHQHVHHHMYHWPPPIGRPHLARMPHVHIISPHMQNNVPPDMIPTYPVPLPDFVFQTRHMNTGFENYMRIVDLRRMSHISCGATQESIENHTFPHKYKRVKKVENGEDAIEKCTICLSEFEDFESVRRLPCMHLFHIDCVDQWLCTNKRCPICRVDIETYFQKELTATV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MYM7</accession>
    <name>A0A8J2MYM7_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HICCMSTLAB_LOCUS11754</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5103927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MYM7"/>
    <dbReference type="OrthoDB" id="6250593at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903078">
        <property type="term" value="P:positive regulation of protein localization to plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003009">
        <property type="term" value="P:skeletal muscle contraction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039688">
        <property type="entry name" value="STAC1/2/3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15135">
        <property type="entry name" value="STAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15135:SF7">
        <property type="entry name" value="STAC-LIKE, ISOFORM J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG5103927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="334" mass="37613" checksum="A1A16DB5A6EE5A2A" modified="2022-05-25" version="1" fragment="single">VSEFAQELGGAIENHAANVRRIVDEFRGRSSESRNDVGANGIRRLWESLLRQVEADAAAQLDLAAVLQQQISRPAQEACFYRKIQSRKVFAHREAYEQVVSKTEEKLQRARVDYKRAYGALLTINESTASEQEQNNLKRAYFDAHNAYVLQLRATNAIAERYQFHCLPTLLGEIAEVYEELSGLTCGCVTRIAEAAGERVSEQTKRYQTIVKEAQNISAQNDLQVIAKNLSSTTTPKKPPRRLFVPPSPPEQVPMDKINQVPALRDELVPTGINGQPNLEDLRREADSLTLEIGRLQDSLDALMRMQRKSAESNLFTKAAELQEDISMKRFDLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2N0D8</accession>
    <name>A0A8J2N0D8_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Similar to Oatp74D: Solute carrier organic anion transporter family member 74D (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HICCMSTLAB_LOCUS13540</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the organo anion transporter (TC 2.A.60) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5108904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5062115at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015347">
        <property type="term" value="F:sodium-independent organic anion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043252">
        <property type="term" value="P:sodium-independent organic anion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17336">
        <property type="entry name" value="MFS_SLCO_OATP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002350">
        <property type="entry name" value="Kazal_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004156">
        <property type="entry name" value="OATP"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00805">
        <property type="entry name" value="oat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11388">
        <property type="entry name" value="ORGANIC ANION TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11388:SF131">
        <property type="entry name" value="SOLUTE CARRIER ORGANIC ANION TRANSPORTER FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03137">
        <property type="entry name" value="OATP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51465">
        <property type="entry name" value="KAZAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="29"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="65"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="93"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="173"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="209"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="256"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="344"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="383"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="415"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="583"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="725"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="764"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="791"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="873"/>
            <end position="892"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1016"/>
            <end position="1035"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1055"/>
            <end position="1075"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1087"/>
            <end position="1106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1203"/>
            <end position="1227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1239"/>
            <end position="1264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1292"/>
            <end position="1315"/>
        </location>
    </feature>
    <feature type="domain" description="Kazal-like" evidence="10">
        <location>
            <begin position="452"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="964"/>
            <end position="992"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="964"/>
            <end position="975"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="976"/>
            <end position="990"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAG5108904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="1339" mass="147915" checksum="8CA998DBDD6CE06C" modified="2022-05-25" version="1">MTEPRPTHCGLCGIYPTWLQKRATPHTFILVYGFLGLVQAMAFIYIVVTLTTLEKRFKIPSQTTGIILSGNEISQILSLILMYYGGAGHRPRWLAAGVGFSALSCFILVIPHLIYGPGKAALALTQEHLEESIFLNSTKAGSSNSPTYLCPGTNDHDKCDEEDLMDGSLLPRFLVFMSQFVLGIGTTLYFGLGQTYLDDNTKKSNTPMLLGFTFALRTTGPALGFILAYACLKLYIVPSLHPVITDKDPRWLGAWWLGWIILGCLLLIFALLIAMFPKHLPKDNKKKNNNKNRIEGELPLKIHNGIERVPELPPRIEKCEEENAHQPSLKDFPVTLKRVLSNKILFCNNLSAVFGIFGLLPYFTFMAKYLEVQFNTSAAGGTVITGPIALVGMVLGFLGSGFFISKVKPRPTRLLSWNVFGGFVAFFIQISYIFIGCNQVPIEGVNSITMEVNFTTACNVGCNCDGVKYAPVCHEASMTSYFSACHAGCTSLIDARHYGNCSCVPSTANYLAPEKYYNDNYNQNTSQPIPDDTVVLGPCLGNCINSYITFIVLSMICHCLMSTGKIGNVLINYRCVQQKDKSVAQGVTLMFISLFALIPGPIVYGFICDQSCLIWEKSCGTTGNCCKDLDLYGANEDKLKGNKVPECNMTKKETADVNKNGPESKLLLDTSRNLTVENNKLKTTSPTSLRGIDDIFRDLPLTDDTSCGIWFFRGPNLQKFANKNAYVFLYGVLGCIFSASYAYFNGTITTIEKRFKIPSKTTGLITVGNDISQLLVSVVLSYYAGRGHRPRWIAVGIYTVVMFCCLTMLPHFLYGPGEDALQLTKEYGGKPVNSSESDMHWSGNRERKFLCQGTENSKPVCDDTDGSNFAPQVLLFTAQLVSGIGGSLYYTLGVSYMDDNIKKSKTPVSISFSYFLRMLGPAIGYGLASFSLNIIALFPKTLPRAAARKVLALERSKSTASYREQERLAEKKNLDEDGEDGNGIVDDDFDEKSPEVPASFEDMIETFKRLLSNNTLMCNNLATVFYFLGYMPYWIFMPKYIETQYKQSASVSSLITGTVGLVFSAFGILLSGLVITKYKPRARYLAAWNIIVGAVSVMGMISYAFLGCSANDNQVMSIQDTSGELKTQFPCNENCNCDYVTYNPIDSNGTKVYTDCSCVRTRYSRASFNKSEMSLSTGFKSSTTPEMGTAVPGPCPVDCMHKFYLFLAVVCLLKFSGATGRASNFLVSVRCVAERDKAVAMGFGLTIMSLFAFIPSPILFGFILDKTCLVWGKTCSGTGNCWLYNGEALRYLLNFTAATFVTIGTFFDIGVWYFVKDVKIFDDDIELNDVKDEPLPESL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2023-09-13" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>S6D9M6</accession>
    <name>S6D9M6_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Cc_single_14.3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">CcBV_14.3</name>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS1427</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Philos. Trans. R. Soc. Lond., B, Biol. Sci." volume="368" first="20130047" last="20130047">
            <title>Functional endogenous viral elements in the genome of the parasitoid wasp Cotesia congregata: insights into the evolutionary dynamics of bracoviruses.</title>
            <authorList>
                <person name="Bezier A."/>
                <person name="Louis F."/>
                <person name="Jancek S."/>
                <person name="Periquet G."/>
                <person name="Theze J."/>
                <person name="Gyapay G."/>
                <person name="Musset K."/>
                <person name="Lesobre J."/>
                <person name="Lenoble P."/>
                <person name="Dupuy C."/>
                <person name="Gundersen-Rindal D."/>
                <person name="Herniou E.A.Drezen.J.M."/>
            </authorList>
            <dbReference type="PubMed" id="23938757"/>
            <dbReference type="DOI" id="10.1098/rstb.2013.0047"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CAJNRD030001116">
        <property type="protein sequence ID" value="CAG5075273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="HF586477">
        <property type="protein sequence ID" value="CCQ71344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S6D9M6"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5075273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCQ71344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="155" mass="17766" checksum="745DF27A21A58358" modified="2016-04-13" version="1">MNYSLFVYLFFICNISNDLHTKTMIKGHNTVKGICDGLISNKYTQKTMLKGRNTIIHVYDGLISNKYTQITMLKGRNTIIRVCNGLISNKYTQKTMLRGRNTIIHVYDGLISNKYTQKTMLKGRNTIIHVCDGLISNMKDELSGMYCYCINCRGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2E6U7</accession>
    <name>A0A8J2E6U7_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Endonuclease/exonuclease/phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS1560</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001116">
        <property type="protein sequence ID" value="CAG5075406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2E6U7"/>
    <dbReference type="OrthoDB" id="1421278at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5075406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="678" mass="77610" checksum="D291CEBA70F55D09" modified="2022-05-25" version="1">MGNFGHLPEEALEYTNFTGKRASLDQVCNHQGKILALFMAENGFILLNGRSPGDSMGDFTFSSPLGNSTVDFIWVDVSGLHLVGDMWVDNRITGSDHFPITISLLLNAPLPVNNVWSEDRQSNITKWRPECADRYRYCMEWSPLVKIDLNEATVEDFNTQLKKGIDSAANDAQMSLKEQSCTFNHSFKSWFDKSCRALNHTLKILLKKCKAAGNDVYLWSEYNRKKKEYYTYLKGKKVHHITTIQDKFACAKNSKDFWEVVETVRKPPYRASKVSLQKWENFFQEVYPPRELYLVVSDVHEHPILDAEITLEELQLSLKKSKSDDIAMLFRSANHLLRGLKILENYCNLNSMQVNISKIKVLRVSSTGKSRRKCPTFLFNEETIEMVNSYTYLGVVFTAGVIGIPTVKYAVNKSKIATGTALTVLAKLKADSWCGKIKIYNGLVNSTLLYLAQIWCLRPDFIETVEAAHLDFFKRLLNLPKCTPGYALRSEMNIPHIATDILQLAINWGIKILKLENHRLPELCLFRLAELRNSSTNQHKCNWAHQLSNLLRTVNEEQLLDNPDADYRSARKNIILRKFRCHLALADRERYSRSSSCQTIFSIPLFEVIPELTLRVPHHLSKPIIQLRLASKYACYLSINSESINLSPLKDCKFCSTGSKETILHVLIQCPLYSDLRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2EBE0</accession>
    <name>A0A8J2EBE0_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BHLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS490</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001114">
        <property type="protein sequence ID" value="CAG5073547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="60033at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BHLH" evidence="2">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="116"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="140"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="430"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="641"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="772"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="852"/>
            <end position="925"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1049"/>
            <end position="1085"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1137"/>
            <end position="1282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1328"/>
            <end position="1394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1433"/>
            <end position="1468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1536"/>
            <end position="1571"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1656"/>
            <end position="1721"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1883"/>
            <end position="2030"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="148"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="181"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="229"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="255"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="441"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="452"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="642"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="773"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="852"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="881"/>
            <end position="925"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1052"/>
            <end position="1082"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1141"/>
            <end position="1151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1152"/>
            <end position="1161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1166"/>
            <end position="1178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1179"/>
            <end position="1202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1203"/>
            <end position="1269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1363"/>
            <end position="1373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1381"/>
            <end position="1394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1434"/>
            <end position="1462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1557"/>
            <end position="1571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1665"/>
            <end position="1676"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1703"/>
            <end position="1715"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1893"/>
            <end position="1909"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1962"/>
            <end position="1975"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="2007"/>
            <end position="2019"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5073547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="2060" mass="228739" checksum="77BBA93204495AC8" modified="2022-05-25" version="1">MNLYFKTLGDLLPPSQDGKNRNKVDILIQASKYIKDLTNRTEELFNTNAVDAHKEELIRLKKLVTQLYSRTQLLSALLKDAGITVPAEPALEKISPLKWSNKINVEDAEKYLDRFKERKKPEKRRNSTGLKIPLNKKIKAGAIDVSPNKNNNNNNNNNNNKDISEIIGPVEDQENHVGSNIDDKNGEDKNNESTTKISDVRNNSDPDSSEPAIESPAGPKSSTGIRKLESRKKLKRKTSISKDNPSKKSPKTARKSPASKSSSIALSSTSKSQNSSITNLVSGTLILSNGKLMPLITPLASTNILVNANTSNQQPSNQQQPQLIISSNQTPTSPMIFMQSVDCNNIKNVSVQNQNVINAVQKVTLNTIPSIRTNVAINSHDWVSNVKTIIEATKIGGRKGILPKGKEITKTTMAYKVPIPVVRRDIKTNSGKSVSDIKSGSKNKKSKGAKSKKTDKVKSSSKSTKEKSTDVPSKDKLSIDNKVSTTEIKKLPETCESIGSLRNVVEKIGEVSHENSKINEPGNENEASRVENLNAETEANVSRDKNVIKTFDLTPEIDCVNKNQSTEKITSVVAESTSTVELTTESLTIEKVIEADINKATKVKEVCDLNTRFNLLNESSDNSTIDSTKIILNLDTNTTTTMKPETSNKASSSASAITNSVTGPPSEIKEEKLIKEPKTLYSNDNSFVPISNRDLHSDLSNDLFASLQVPSNSHNPESISPTAAFLMAFPLVSSLNGKTEVLEEDMKEDLKYHSQTPPMLLQIGTIEPNSFKVKSDDIKNSDNKTQKHGEDKSEDNCSKSLPKIVNNETFKDKLYRIVPYSKPVATSVSSLTNSSTTSVSSTAGVTGVASNLNSRTNLTNCDIDSNKKLNEKSNTGLSKFDNNVSTSSNNNSNNNDTSTTTSNNNNNNNNNNNNNNNNNDRNANNLIISSTTDNAKLPKYNNPTRYQTTLLNDYTSNYTNFTGTNTEDNQQMLPIDNSRNYTTNNDSINVPYQYSSQDQRVYVENHESSNYAAQKETVFHDQLTRSYTANLNKNSTVTDYQNYLINKESRNELPTQNQGQTLDPNYISPNKQTPTKTNSNDSVKIPPQFGLSGDKISTEHFGASTLKISESEHYDKITENYSGNYIPYTRDDKKIFDDNLHNNTNSNNNNNKCHGQISTLPHYSHQVPPQMQQKQPQQSVANNVKSSAQNSSNFSVLSWTTISPNNSNNNNNNNNNNNNNANTSSTNNNNTNNNNNNNNNNNSNSGNNTAVNNNSTNNKPTKSKNTSNNLVRFENPEQNTNENKTICENFNYSSLHKNPGFNNNIGQSFSAELSLTGVEKKTKLTATTTDKTKSVGPATQKSRSSIDDYSGNKINSKKFPMDTNYTQEFTLDQQQRHTTKSHQVPSKTDNKSYNTYDTTINFDVPESVNSSKCSTDIYSGNIKYQPILHDPYASKQPQQQSQPQQQQQQQQLKSKPVQQQQQAVRPPVNWMMPSEIKHNTNMPDIILPPIGKELEFCQNNIFSQPPSYNQPAATSTQFYNNYDVTVSAASFPNVSTLQTDSRRLTDPTTYYPDDQHFSWSPTKNSQSTDHSQVIKSIEQQQHQQQQVVPSTLPTLVGDLALGTVAEKSSSFMFGQRNDVPQTKAVKDKDFAVMNEQNVQHPVQSGSFLSVSQLVEHEKAEKHQQGHSLHQQHQQQPQRKHQRKSNTSPRTTGRRQMDMRKTDQLQQQQQQQQQQQHDQKISHGFAGSSDAYQQQKYQQQDGLWRNRNCKSNYTAEALIGVNTSSSIQDNNHPDKQLHAIKFSTDYSQNKFPSGLSADMVMPPINYLANPDDGNGYGQVMNQNFNHTSYTYSPNANIYPPTNFIAGISAGNTPSSYMMPLHDNPADYLEANSFLLPNVTSNVGNPPKSTVDMPTSVTVSTTRVSASTTTTNGKNTHYGNGGKHHQNCDTKRNYASVSKKSKKKSDPMHMDFSVPGVTVEDYPHHHHHHHHHHHHGHSSTFLPPPPPPPTHTNSLYQNPPHAMGMGLTSNSNRSRSMGSNSVAMTHHPSGTSLTNFNLSTIFPEINDKAARPPGPSTYYFSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2EC66</accession>
    <name>A0A8J2EC66_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Similar to GCR2: Putative tyramine receptor 2 (Locusta migratoria)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">HICCMSTLAB_LOCUS1320</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001116">
        <property type="protein sequence ID" value="CAG5075166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2EC66"/>
    <dbReference type="OrthoDB" id="5955450at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004989">
        <property type="term" value="F:octopamine receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15060">
        <property type="entry name" value="7tmA_tyramine_octopamine_R-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002002">
        <property type="entry name" value="Octopmn_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24248">
        <property type="entry name" value="ADRENERGIC RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24248:SF174">
        <property type="entry name" value="TYRAMINE_OCTOPAMINE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00664">
        <property type="entry name" value="OCTOPAMINER"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 11" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 11 15" id="KW-0675">Receptor</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 11" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 11 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="36"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="74"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="111"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="153"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="196"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="365"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="398"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="14">
        <location>
            <begin position="53"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="232"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="12"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="12">
        <location>
            <begin position="246"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CAG5075166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="435" mass="47605" checksum="6E0FBEE679188310" modified="2022-05-25" version="1">MNASGESGGTMSSDDYSESCTSSEEDTGANLPSWEAAAASLTLGFLVLATVLGNALVILSVFTYRPLRIVQNFFIVSLAVADLAVAILVMPFNVAYLLLGKWIFGIHLCKLWLTCDVLCCTASILNLCAIALDRYWAITDPINYAQKRTLKRVLATIAGVWILSGAISSPPLAGWNDWPEEIEPGTPCQLTQRQGYVIYSSLGSFFIPLLLMSLVYLEIFLATRRRLRERARQSRFGVVSSTKNKGGAGPGGSGPGGTGGRDNAGGSHDPDDAEESVSSETNHNERTVTTRVHGKPSLVVVEDDAATEVTLNMTPCRGGKREKHPAATVTTANANATTTTTTVYQFIEERQRISLSKERRAARTLGVIMGVFVVCWLPFFLMYVIVPFCPACCPSERMVYFITWLGYINSALNPLIYTIFNLDYRRAFRRLLHLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2ECW7</accession>
    <name>A0A8J2ECW7_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Odorant binding protein 442.12131</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS1701</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001116">
        <property type="protein sequence ID" value="CAG5075547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2ECW7"/>
    <dbReference type="OrthoDB" id="8194670at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035275">
        <property type="term" value="F:dibutyl phthalate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005549">
        <property type="term" value="F:odorant binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042048">
        <property type="term" value="P:olfactory behavior"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007608">
        <property type="term" value="P:sensory perception of smell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23992">
        <property type="entry name" value="PBP_GOBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.20">
        <property type="entry name" value="Pheromone/general odorant binding protein domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006170">
        <property type="entry name" value="PBP/GOBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036728">
        <property type="entry name" value="PBP_GOBP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21364">
        <property type="entry name" value="GENERAL ODORANT-BINDING PROTEIN 19A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21364:SF1">
        <property type="entry name" value="GENERAL ODORANT-BINDING PROTEIN LUSH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01395">
        <property type="entry name" value="PBP_GOBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00708">
        <property type="entry name" value="PhBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47565">
        <property type="entry name" value="Insect pheromone/odorant-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5075547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="126" mass="14536" checksum="9BD4D2DE21564FAC" modified="2022-05-25" version="1" fragment="single">MLCIDMKIILNIITNLLLYIILVQADIKRDCRKKTGVSWGSLMKLKKADYNLNDQQLKCYLLCFMQKNGIFDKDDINVEKALRHLPRGVQGASKKTLEYCKKIPSNDTCDKAFQLAKCYFKAQPEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2ED25</accession>
    <name>A0A8J2ED25_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">peptidyl-tRNA hydrolase</fullName>
            <ecNumber evidence="1">3.1.1.29</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HICCMSTLAB_LOCUS1792</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>an N-acyl-L-alpha-aminoacyl-tRNA + H2O = an N-acyl-L-amino acid + a tRNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:54448"/>
            <dbReference type="Rhea" id="RHEA-COMP:10123"/>
            <dbReference type="Rhea" id="RHEA-COMP:13883"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:59874"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:138191"/>
            <dbReference type="EC" id="3.1.1.29"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.29" evidence="1"/>
    <dbReference type="EMBL" id="CAJNRD030001116">
        <property type="protein sequence ID" value="CAG5075651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2ED25"/>
    <dbReference type="OrthoDB" id="201213at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004045">
        <property type="term" value="F:peptidyl-tRNA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd02429">
        <property type="entry name" value="PTH2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1490.10">
        <property type="entry name" value="Bit1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023476">
        <property type="entry name" value="Pep_tRNA_hydro_II_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002833">
        <property type="entry name" value="PTH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042237">
        <property type="entry name" value="PTRHD1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46194">
        <property type="entry name" value="PEPTIDYL-TRNA HYDROLASE PTRHD1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46194:SF1">
        <property type="entry name" value="PEPTIDYL-TRNA HYDROLASE PTRHD1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01981">
        <property type="entry name" value="PTH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102462">
        <property type="entry name" value="Peptidyl-tRNA hydrolase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00048707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG5075651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="204" mass="23305" checksum="EA30753D10A811A9" modified="2022-05-25" version="1">MENSNSGRFNFKFCCNPRKLENHRAKKSLRQASVKQQTAHNLTNKDYLCTSCRKALDSQITAFNSVVKVNDCVEEELKEVRSKTSEVPLIVQYVVIRGDLLKTMGWPVGAVIAQACHASTAVTHMFYNDPHTQKYLADLDNMHKIVLEATDESKLTGLHSKLSEAEIDHKLWIEQPENIPTCLVCKPYPKSEISKFFKKFKLFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2EDG8</accession>
    <name>A0A8J2EDG8_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS2035</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001116">
        <property type="protein sequence ID" value="CAG5076054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2EDG8"/>
    <dbReference type="OrthoDB" id="7701089at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="115"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="137"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5076054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="154" mass="16268" checksum="C87C3A34BF70D9DD" modified="2022-05-25" version="1">MLESVRQSSTARGMKDAMRRARDEAPRRGARGRGRADSNGLTHLSPARPIPGDGAEACARKLYPTERHTGTSLQSGAHRLNSVEDSAEKVEGPGTQGAKESSNDSRDEDSANDISSTLSGLLAGLPALPGPQRLASSLRQRFSTNSGKTTKDSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2EEJ2</accession>
    <name>A0A8J2EEJ2_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Olfactory receptor 176</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HICCMSTLAB_LOCUS2093</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001116">
        <property type="protein sequence ID" value="CAG5076112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2EEJ2"/>
    <dbReference type="OrthoDB" id="7634903at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005549">
        <property type="term" value="F:odorant binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004984">
        <property type="term" value="F:olfactory receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004117">
        <property type="entry name" value="7tm6_olfct_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21137">
        <property type="entry name" value="ODORANT RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21137:SF35">
        <property type="entry name" value="ODORANT RECEPTOR 19A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02949">
        <property type="entry name" value="7tm_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0552">Olfaction</keyword>
    <keyword evidence="8 11" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="9" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="25"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="61"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="132"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="270"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="309"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAG5076112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="405" mass="45808" checksum="D9C115FFEA84233B" modified="2022-05-25" version="1" fragment="single">MTKLGLKVCGVWPNIRRPNWLRTLISIRVTIATLIVAIFTLIPGLFALVKVWGNMTLIIDNLIITLPFFTAVFKLNVLWSKEEGTKFVLNCEICAKVQKLFDDISEDWSRPRSELERNIMLKTATVARNVTIFAYILVIWVILIHHLPLWVAGIVPRTPTNLTDGTRALVMQTIYFYDETLTPTFEITATCQFLSSLVAGSSYTTIDCVFGALILHVSGQLQVLEVKVQNLCDHYDKATKCLDKVLFQKDLNLVARAHQRVILFVERMENIFCMMLLEQFTAFAIIFATEGFNVISVLTGDVEGSFSTMSFSISYFIYALFLIFLYSAAGEYLIDCSTKIYHAAYNSEWVNLETRDMYQIIMIITRAQKPLVVTAGKFAPLSLSTFAKLIKTSAGYMSVLLAVRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2EGS4</accession>
    <name>A0A8J2EGS4_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS1321</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001116">
        <property type="protein sequence ID" value="CAG5075167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2EGS4"/>
    <dbReference type="OrthoDB" id="2155935at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="73"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5075167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="123" mass="14214" checksum="4F1F87A366C24C9C" modified="2022-05-25" version="1" fragment="single">MRTRVFRRSHLPPVKSNYGQDELYRSFINFFHGHEGLFRKVYVRDDDSVGKNQEQLESPDDTNHLEVNNEIETSVKISDENNMNNSTDNDKNKVVENPEAEKDAQKNPKRPSGSKPHLRSSSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2EKF2</accession>
    <name>A0A8J2EKF2_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Histone H2A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HICCMSTLAB_LOCUS1922</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subunit">
        <text evidence="9">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the histone H2A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001116">
        <property type="protein sequence ID" value="CAG5075908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2EKF2"/>
    <dbReference type="OrthoDB" id="9421954at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00074">
        <property type="entry name" value="HFD_H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000005">
        <property type="entry name" value="Histone H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002119">
        <property type="entry name" value="Histone_H2A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032454">
        <property type="entry name" value="Histone_H2A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032458">
        <property type="entry name" value="Histone_H2A_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23430">
        <property type="entry name" value="HISTONE H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16211">
        <property type="entry name" value="Histone_H2A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00620">
        <property type="entry name" value="HISTONEH2A"/>
    </dbReference>
    <dbReference type="SMART" id="SM00414">
        <property type="entry name" value="H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00046">
        <property type="entry name" value="HISTONE_H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="8 9" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="11">
        <location>
            <begin position="12"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="Histone H2A C-terminal" evidence="12">
        <location>
            <begin position="99"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF16211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAG5075908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="132" mass="13889" checksum="1E76BF87F14E599B" modified="2022-05-25" version="1">MVSPRAGGKTGKDSGKAKAKAVSRSARAGLQFPVGRIHRHLKNRTTSHGRVGATAAVYSAAILEYLTAEVLELAGNASKDLKVKRITPRHLQLAIRGDEELDSLIKATIAGGGVIPHIHKSLIGKKGSQKPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2EKN0</accession>
    <name>A0A8J2EKN0_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Similar to Sytl5: Synaptotagmin-like protein 5 (Mus musculus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HICCMSTLAB_LOCUS2074</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001116">
        <property type="protein sequence ID" value="CAG5076093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="195679at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070382">
        <property type="term" value="C:exocytic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042043">
        <property type="term" value="F:neurexin family protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08521">
        <property type="entry name" value="C2A_SLP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000006">
        <property type="entry name" value="Synaptotagmin-like 5, isoform CRA_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45716">
        <property type="entry name" value="BITESIZE, ISOFORM I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45716:SF2">
        <property type="entry name" value="BITESIZE, ISOFORM I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="C2" evidence="5">
        <location>
            <begin position="2002"/>
            <end position="2124"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="5">
        <location>
            <begin position="2162"/>
            <end position="2249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="39"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="100"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="197"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="341"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="398"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="587"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="722"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="774"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="858"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1160"/>
            <end position="1193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1290"/>
            <end position="1309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1328"/>
            <end position="1511"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1693"/>
            <end position="1737"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1841"/>
            <end position="1920"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="41"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="202"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="239"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="270"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="314"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="603"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="632"/>
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        </location>
    </feature>
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        <location>
            <begin position="643"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="680"/>
            <end position="694"/>
        </location>
    </feature>
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        <location>
            <begin position="728"/>
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        </location>
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    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="775"/>
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        <location>
            <begin position="1160"/>
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    </feature>
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        <location>
            <begin position="1183"/>
            <end position="1193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="1349"/>
            <end position="1360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1361"/>
            <end position="1395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="1396"/>
            <end position="1410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1693"/>
            <end position="1710"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1841"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1868"/>
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        </location>
    </feature>
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        <location>
            <begin position="1885"/>
            <end position="1895"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1907"/>
            <end position="1920"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAG5076093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="2249" mass="251128" checksum="16E5535FAECD6609" modified="2022-05-25" version="1">MKVIKEKKSLKNKNDSMDIEDSIEKLKVKSRIPDFTGLTIPKSLKYSSQSPSSSQSLTKDVGLSRDSEALNKSSPKFRDISKKSSIPVLRRSEIREYEDINPRNEARRSHIPLQRSTRGSADDLRPPSTPTRIFSNNNSNIINNNYQLEKESSPSLIPKLLLLQKNKRAKFNIEKVNMDVEDFASGEDKNKLDVVVSKDKDQEEEQEEEEEGSKDVKTIVEDDKDDEESAGRRLSSHLSPEASPLSTRSSSRYSPRESESEPTPGLPRKIVAERSESLSSQRIRDAISRTRRESNSSARDRVRDSEATSAGEDDPPRVSDTRSDSAVKFGNVSSQGRTILRRRRQFDSQGSRRRGRSYARSYSTEDISFQIARQSLLRSGSGDSPRIPDYRRLVFISSDSSSGRDEEDDADSSCSGSSYLTGGIPPGTARNTSSHSQSLEDCDWDYFESNSLPSLPSALCSDASGHPINDIKDANVWDCCLGRRLPYPVPVPASLWNNGDFAAAAASSMITASKSDNLKLKNVGPWFSWHPKFISQSEIHRSFYCDPKIMDSGSFNTADSIFTFRPDGSLVGHYESIYHGAHLKFDEPTLNLKDPPKEDNEKSSVQSNNEDTNLEINCNGSDHEISNQVPLDDNNSPSIPDNNNEDDDEDEENSSSCADSSDFDDEEKSHRFSRVFVVNNDDDDDDDEDDENKEEESLLPSYQESADQNGVILKTINSNLENIPVAPSSDSKSTKSVSNNDISYSADSADNLDTITLKSIRNINPEILTADSKSDNVINNNNNNNNNNNDNNVISESIVPDSLEVCKSDKSALEKNAKEWVSYKKNKRIVSDDTLSESMLERQVKAVSEVSELLVGENEVDGSETTGGEPEPVCRGTPLESVELGFPSKIKNYDNKYSNKYKSLVMITSNAYQPVSVITSDTTTLLQPDDSSKTQCDPQQQSSGLAGYYHLALEALETPQRAASGPRRPLMVKRRSDHPTEITDSSELSADFNNFEKTADFNNFEKTPDFNNSKKSANFSNFEKTADFDNFEKSADFNNLKKSANLNNFEKTADFDNFKKSADFNNSKKSADFDRSADFNNFEKSADLNNFEKTADFNYFEKSPDLNNSKKSADFNNFEKTADINSRECSVQKSDSLKLSPTQVDVILEEGLADDDSWVEEVSHDEDEQSTPTTNTEDSSEDEVNHLSGDREEELRGYHRQAIDFTLHTIVEESCEESEAEFSLTWKSKRPPSTSELEKYFFFGLGGVESRPENPDSELENLNNDDLKCLSADTLSREIDSLSETSSVYSEGLESLKDPGINSDSANDNSSRLEKYFLSEFLGFREDRRDSDGSVGSDSEGRPSPEAQRRKRLVRARGTGRSHSSSLDNLLALTQNSGSQNLTSQNSLQDLTNQDSPDESDDSTVPDEDVAGFVEGVDTVKRKKKKRNLGNHAEGSSSNKSPELEEDKDVEAAQVTSEEERSKTPQAEAPDEDDRKQSRDSGFVGSCDDLIQPEPVDNSTPELKNSDENVDDKKEFVAIPINHSLSRKDSFNNWSSDEETNLMMSKMRQFFKTMVANSNSAAAPVVVQQAQELPRGKRTKPPQLVYFENELTRSDLEGAASRSTLQEQISASCQQIISNFDMNSETADQEPNKPTNIKDTAFVYQKLVQSFTKIAGDSSDASSTPYSSPPLIAKVMHHIGSRLVALMHQVSENNSPSNSWRRYPQHTRTPSSASTTEDESTSESAQQTPTFSHLQLPRSKSHDPLLLINSHQVTGAESEEREEKETSDYERFSWRGSFESALMAADSRNKLSLISSGDIGATANVLAMAAKRRSAGDLLFNPKSFSREQLDRVRSCGSIGASNTITTTSSVGQGSVEEKIWSNRRRSSVPDDPRHRRRKSAAEKDQEDNDSEFEFNESRAMTLPRGLQTPTSTSTTNSLPRLPAITSAMHKAHSMRAPVPDEDTLSEACSTPIIGGAKRFEPRSRLQDLNRASLSSLGARSDSMASVYSGAGEGKWCGSVAVRGEVEFSLQYDYKQLTFQVMISQCKDLAPVDVKRNRSDPYVKVYLLPDKSKGGKRKTKVKKHTLNPVFDETLKFNINLNSLENRILWLTVWHSDMFGRNDFLGEVRMPLENKIFDDPTPKWYHLQERSEAFDDPVERYKGEVIVGLKFVPPELCQLENREREGVTIVGEPRKGKKNWSRGSLHVLVKEARNLQTKTKNSGTCDPFCKSYLLPDKGRAGKQKTSVVRKSDGNPVWGHTFIYKDHYLMH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2GZD9</accession>
    <name>A0A8J2GZD9_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Similar to NOF: 120.7 kDa protein in NOF-FB transposable element (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS388</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001114">
        <property type="protein sequence ID" value="CAG5073445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2GZD9"/>
    <dbReference type="OrthoDB" id="7690546at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5073445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="926" mass="106889" checksum="4DC33F4C20EDEAD5" modified="2022-05-25" version="1">MAPAARVSVEDAVAVIEEYIENFREGKYPKWSSDVWEKMSNALNNKWSATNIYTNVTQNRRNIMSIACTNVGIKFIPFMSKKKIEIYDTSDDSINENNSDDADETYELEHEAKNLDKFEVKLTCNEWKAIQSSDVKYNDGRNYSILRRGVWTDILALAIFRDTELPCAFQFKNMKIYNKPESLHYLRVKGYCKSESCKNLIFCYLHEKPLDETDVILTIRTRETFYNQHEEVKRQLRGEKRQRVGKEVYYEGAANWLKREALENIKSRGRIPPHVPSKEVITQAKKEYVDAKLDIKPLDGKDLIKAIENMNHVMPYQGSIHEVKRKKLFISFSTPAQILAYKKYCKMTKSISSVSIDGTGSIAKPLVHEDGSSSGHIFLYSMTINFKNETLSVYDMFTESQDTDVIWWWLKQWLKLAPIPKQAVCDCSRAVMNGISLAFNNQTVKTYVETCFLYAIGDEEYSRREPIHTYLRLDVPHFMNSIRIWTCFKFMRMASVRQFYMYCIALLIDCQTINKFEKIFQLMCIVGLNEFQDSVIQKTNYSVLEARKNLEELIKNRNLDANLEDSINVETKSEVDVKKIENDEETPDDENNCKNENETKKSSRIKNFINNLRDDALFANFIGVELNPFYFPDFIDEFIKLKAYEFPLWTAVAIPYIAEHALTTFVEGHFNIVKHRVLKNHLLPLRLDKLLKLILNYYLGNAAVLTSNLKAFNQYDGPFPSPPSKGNKFTVNLPSQDINTGQSIKKQQCDFIQADSKNTDDNKENINVRNLEENNNNNKIPTKKDELKNCVIINDDSRKKANKAGDNTKFENSTIMKVQDNNLSDQKQKLELRKPKGKYFKTNPQIEQQNSVTGNVQNLKLLLNGSSVKITISVKGSQYFAINTCGFDSIIQILSSSAMDDPSVRYCFNNNRLITIIKYSVLSDGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H0P2</accession>
    <name>A0A8J2H0P2_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS2384</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001117">
        <property type="protein sequence ID" value="CAG5077149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H0P2"/>
    <dbReference type="OrthoDB" id="7693421at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5077149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="121" mass="14011" checksum="0341626B2C1A3A49" modified="2022-05-25" version="1">MILGSSRKLKWLDDYDLPQITVDGNVIPYVNSTKHLGVHITNNLSWDVHVAHTTRKVYGTLNSLKSRKNILSTANLYEHSFLISSIRLWREIPPDVINSFSIEAFKSKAFEFFYELELREA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H0P6</accession>
    <name>A0A8J2H0P6_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS2399</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001117">
        <property type="protein sequence ID" value="CAG5077207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H0P6"/>
    <dbReference type="OrthoDB" id="7667736at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5077207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="192" mass="21701" checksum="7780A02A4AED795F" modified="2022-05-25" version="1">MTICRGSKYFCQHVYVGDAIAEKSTPVRQSSRQLRVTFDEPTPTSRSLLRPPAIEDDNLEGVRMILNNGMDVNEPIITTGQFTGAATILVQLLVNNYKADVNATAADGTRSIHLVCFYQPHPKQIGLFIKGHTYGAIIYTLVQTNANADAEFGRDIFLKHFEDSDWCPDFGDKITLYSFLLFFMIDHYFCIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H2T6</accession>
    <name>A0A8J2H2T6_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="17 18">CDP-diacylglycerol--inositol 3-phosphatidyltransferase</fullName>
            <ecNumber evidence="5 18">2.7.8.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">HICCMSTLAB_LOCUS1675</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>a CDP-1,2-diacyl-sn-glycerol + myo-inositol = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + CMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11580"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
            <dbReference type="ChEBI" id="CHEBI:57880"/>
            <dbReference type="ChEBI" id="CHEBI:58332"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="EC" id="2.7.8.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 18 19">Belongs to the CDP-alcohol phosphatidyltransferase class-I family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.11" evidence="5 18"/>
    <dbReference type="EMBL" id="CAJNRD030001116">
        <property type="protein sequence ID" value="CAG5075521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H2T6"/>
    <dbReference type="OrthoDB" id="10251079at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003881">
        <property type="term" value="F:CDP-diacylglycerol-inositol 3-phosphatidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006661">
        <property type="term" value="P:phosphatidylinositol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1760:FF:000003">
        <property type="entry name" value="CDP-diacylglycerol--inositol 3-phosphatidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000462">
        <property type="entry name" value="CDP-OH_P_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043130">
        <property type="entry name" value="CDP-OH_PTrfase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048254">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014387">
        <property type="entry name" value="CDP_diag_ino_3_P_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15362:SF4">
        <property type="entry name" value="CDP-DIACYLGLYCEROL--INOSITOL 3-PHOSPHATIDYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15362">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01066">
        <property type="entry name" value="CDP-OH_P_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000848">
        <property type="entry name" value="CDP_diag_ino_3_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00379">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 18" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="12 18" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="15" id="KW-0464">Manganese</keyword>
    <keyword evidence="13 18 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14 18" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="16 18" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 18 19" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 20" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="7"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="140"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="166"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00070582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRNR" id="PIRNR000848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU003750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="CAG5075521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="217" mass="24741" checksum="B5A3936AEBE5172A" modified="2022-05-25" version="1">MAESENIFLFVPNLIGFARVILAVISFYFMPTNYVIAIWCYVISALLDAVDGHAARYFNQSTKFGGMLDQLTDRVGTMCLLVNLSMFYPAYAFWFQLSMAIDIACHWIYLHTTILQGKASHKFIDMSENPIMNIYYTNRLVLFLMCAGNEAFYATLYVLHFTEGPMILGLSLFKIMLFISAPVAIVKSCISILHGYVAAINLKYFICDNQRVVNYFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H5A0</accession>
    <name>A0A8J2H5A0_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS1551</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001116">
        <property type="protein sequence ID" value="CAG5075397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H5A0"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="79"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5075397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="110" mass="11874" checksum="B296DCE591401B59" modified="2022-05-25" version="1">MTGQALMDEVDLYEEYIRQKICDLLRGPRQPNKTKSEASQKNDTKDKNEVPAAASGDMNPELNITNPTNNTHDDKSTSSEKSSVGDSSSSEGSSGPSNEESKSASDDSME</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H672</accession>
    <name>A0A8J2H672_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS2555</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001117">
        <property type="protein sequence ID" value="CAG5077775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H672"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5077775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="21" mass="2557" checksum="BCE93A3037EA7C92" modified="2022-05-25" version="1" fragment="single">MTNSRSSFSYLIRERVRVKAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H6K1</accession>
    <name>A0A8J2H6K1_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS2903</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001117">
        <property type="protein sequence ID" value="CAG5079014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H6K1"/>
    <dbReference type="OrthoDB" id="7693454at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032062">
        <property type="entry name" value="DUF4803"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47890">
        <property type="entry name" value="LD24308P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47890:SF1">
        <property type="entry name" value="LD24308P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16061">
        <property type="entry name" value="DUF4803"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5079014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="282" mass="32979" checksum="45FB25605880335A" modified="2022-05-25" version="1" fragment="single">YSNGRVSTGPDDYISCGKRVLFGKLFNDFYRHMVTSYLKEYVIRYYLDIINAQYLDQTYSSAKIDEFIFISRLQREISSMKAKGDTTNDYLWRCDLPSYDNSNGTLYYEMTHMMQTVIVKEENLDIHQSCSHNCDTWYIEDSMNYTECDGYYHCRYIDSSYEICEPVSSLIKNQTHWSPRTCSESRYSDEMEYELDLPIKSPQNSIDKYRGNVLFHYSGLTKDAGQSTVPFFDGQDVEGDPEFSLGGVGVIHRTRKGYGGFLAFRIYMPIFGQNFKNELYEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H6M3</accession>
    <name>A0A8J2H6M3_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Similar to fnbp1l: Formin-binding protein 1-like (Xenopus laevis)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">HICCMSTLAB_LOCUS2830</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the FNBP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001117">
        <property type="protein sequence ID" value="CAG5078761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H6M3"/>
    <dbReference type="OrthoDB" id="8783038at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11619">
        <property type="entry name" value="HR1_CIP4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11911">
        <property type="entry name" value="SH3_CIP4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000203">
        <property type="entry name" value="Cdc42-interacting protein 4, isoform F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.470">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001060">
        <property type="entry name" value="FCH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011072">
        <property type="entry name" value="HR1_rho-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057870">
        <property type="entry name" value="HR1_TOCA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15735:SF12">
        <property type="entry name" value="CDC42-INTERACTING PROTEIN 4, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15735">
        <property type="entry name" value="FCH AND DOUBLE SH3 DOMAINS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00611">
        <property type="entry name" value="FCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25610">
        <property type="entry name" value="HR1_TOCA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51860">
        <property type="entry name" value="REM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 11 12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="REM-1" evidence="15">
        <location>
            <begin position="299"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="14">
        <location>
            <begin position="458"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="384"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="100"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="306"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="415"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CAG5078761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="522" mass="58299" checksum="8A1704EA42AA58B2" modified="2022-05-25" version="1">MPRVWELDARRLDHLAVFPSSTMSWGTELWDQYDNLSLHTQKGIDFLERYGHFIRDRCKIETEYAANLSPCRAFKLELNEVNDQAGQREVIAENLTANVLKELNILVKDFKEDRKKYLQEGARLMSTLTAQIQSLERARKAYEKAFREAERALENYQRADADLNLSRAEVEKQRMNMTLKTQQKRAVAPIISQCLEGIEKAANEVNEKEDTLLVIERFKSGFQPPGDFPFEDLSVAKSYDSNTQLSQTATMQPIHNHLTVKGTVSGGKIKKRVGIFGIFSSNKNNVPGYGDGAKEDCSDLPPNQRKKRLQQRLDEIQAKIAQETAARDALMKMKGVYEQNPALGDPMSIEGQLNQSGQKLDKLGTELIKFQGYLDDAIKTGVGLSSHSGGEESLSRSASDSSVGNAHAQAHKHTTSPSTPQPTHDSTNSPESGLGASRTSLPGSNAEEYDVDELDAQPPLGTCRALYPFDGTSEGSIPMYDGEELYMIELDQGDGWTRVRRMSNPVEGFVPTSYIEYQLFDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H712</accession>
    <name>A0A8J2H712_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS2750</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001117">
        <property type="protein sequence ID" value="CAG5078470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H712"/>
    <dbReference type="OrthoDB" id="6363232at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="120"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="168"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="301"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="702"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="990"/>
            <end position="1010"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="68"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="86"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="138"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="305"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5078470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="1066" mass="122460" checksum="42659FAC06CCA7B7" modified="2022-05-25" version="1">MQIYSEALLLRTKGQIIGLSIVSIDSRQSTMPWTIFKKLLLFNIIAILAINNYTSAATNHRKRYIQRNNNNNNNNNNNLSTNQDYNNTKNINTSNNNNSSEIERNAPKNIQDMLKDDKELPDDTAKWDSLQSSSTGNGKEKKFTRDDDDDKKTLAQQVKEGKYGLIQNELSPKKPKRPGIISYSSNPDIPRDNAKNFGGLDNEEIWLAENHLLVIKGGNYDDNEKGSRKNLRDWEPIDDYEAPKRQVRIPANPKIPPPFPIQLTDGGPIKIIGRNSSENDDNESSAQWIIPDGLVPFNGTYFIQNESSNDTNSNDENDGRKTKSSPTFAGIIGPFFPALPPGAIFVPPPSNQTDYDEDDQSIYYPPVYSFKYQLDNSTVVPPGPLVPGIILPPPPDFFAPLEENNETVKDKVCLKCNAESVSTTAKSEKINKINRMESSTRETPKAKLKYSPVNKNKLDNYISIQSTTPKSNVIEGRTEKAKVSTSTPKKIRPIVAYYSTTPYKKLIEKTTPTPVTTEKLNSNLKASYYYYEEENEVTTPEPINYQDNEARLSYYKLVVKELPPKSIYRKLRPSTPLPVLSSTISTPSSYYDVEITPSQQTLQDYQTIEPPVQSLKPQVKNSRVQGQRMLKSNFETTNPYYDKQFISSSPAPVYNFKPIITSTPRSREFLSTTKKYITNKVKSKPIYQYSFQAANYAHDPVVYQNDGADNNDSSEGDIDNNDNNNKYYNKWQVQKEFKEEKPFYNKWQDDLRYNDDRFRVSTNKFNYASTTQAPLSVLRHRGTTVTSNNYYTKQEDQYLDDVTKEYFTNFGRKIKYRLPSTTPIYSGSTEAYESVTPRPRYQIKPESEDRDKNYYDKEIKENEYYDNIYSLKNDINVNYQRPLPTINPDAEFIDDYDSQVKIKTGDKYKQYHYQSNYASLLPVDSYNNNYNNDNSYNQRVPSDFISLGIREQKYYERIKGQKPISLAGDVNVNYNNPPPINPDAEFIKVPHSHSHPHPQSYSNANSNVRQNGELRDDHRSYFTYRLPGDDGHVYFFTPHVINRQRQEFGGSRLRGFRTAKAVKHNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H753</accession>
    <name>A0A8J2H753_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Similar to Senp3: Sentrin-specific protease 3 (Mus musculus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HICCMSTLAB_LOCUS3066</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C48 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001117">
        <property type="protein sequence ID" value="CAG5079653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H753"/>
    <dbReference type="OrthoDB" id="1939479at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016929">
        <property type="term" value="F:deSUMOylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016926">
        <property type="term" value="P:protein desumoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.395.10">
        <property type="entry name" value="Adenoviral Proteinase, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003653">
        <property type="entry name" value="Peptidase_C48_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12606:SF10">
        <property type="entry name" value="SENTRIN-SPECIFIC PROTEASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12606">
        <property type="entry name" value="SENTRIN/SUMO-SPECIFIC PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02902">
        <property type="entry name" value="Peptidase_C48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50600">
        <property type="entry name" value="ULP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 7" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0788">Thiol protease</keyword>
    <feature type="domain" description="Ubiquitin-like protease family profile" evidence="6">
        <location>
            <begin position="391"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="291"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="331"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="607"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="298"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="332"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="360"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAG5079653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="856" mass="99342" checksum="DAA80DEC6F2802D3" modified="2022-05-25" version="1">MGKRKKPGLFPNQPKKLKPWSAETKNKTGRSFNSQMQGAIYSLYKFMKAEPDNKGPIIPLSQVRDRNISFNGQRETLRRVLHDIGFTYKRRNGIYYLIERPDIVRKRQRFMEKYIDAVRQGYYPVFEDETWIYKKGSSKTREWQNNDSRSCSLEKQPTAKWRRDEIQVWLEKNNVDFKRDSFKAVLLELCRANKKPIKYVIDELLAKNTDHIINRLPAYHCFYNPIELVQGLVKRYFDKHVGLGHDYSEDSMLMHWENALDSVTPEVWKNCVEKVEKRIFEDYEREFGNKQKLPNFDEVPDDEDTESEDDDDPDDLKLPIDADSVKRALFANGNTDSNAEPSVNNDSVTEEKKTEDPVASTMTSDENQLPASVSNWLKEPEETVISNKTGIALRVFDLKTLLSSHLLNDQIINLYLRLVVQSEGSHFYAFDTHFYPQLLKSYDSVKNYTKNVDIFSKKTVLIPVHSAELRHWSLCVIHFDQKKISYYDSLNYVNKSCITTVFQYLHQEHSIKKSRHWNDSNWKDIQETNLPQQNNLTDCGVFVCKFAHYICKNAPFTFTAADMPKIRRTMMEEIVLLKLQPITPQEPQTSAISRSISAFARDLKQARVPTKTCSKKKEPPRKSSTSKELSSTVKPLCEIRTSLEGVYLHQSANLHQGDSRFPEDRRNAQCTAIVAYSIAALILNNGEISRTFLDNIVRDGDQYYVDSKKENQVKEAFLQPEELLKIFHVNHQEVTIDIDHCGEGHFFSSGLITSLTAAIDYCVEICKEQLDQYGFLFIGHGKTVSFKISSKNHKHFFMFNSHSVDNNNCYPKNGPKKGVARLFRCLSSRCLASLLIQNHPRDERYWQIYRIKVSST</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H7L2</accession>
    <name>A0A8J2H7L2_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ubiquinone biosynthesis protein COQ4 homolog, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">4-hydroxy-3-methoxy-5-polyprenylbenzoate decarboxylase</fullName>
            <ecNumber evidence="8">4.1.1.130</ecNumber>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Coenzyme Q biosynthesis protein 4 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HICCMSTLAB_LOCUS3572</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Lyase that catalyzes the C1-decarboxylation of 4-hydroxy-3-methoxy-5-(all-trans-polyprenyl)benzoic acid into 2-methoxy-6-(all-trans-polyprenyl)phenol during ubiquinone biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>a 4-hydroxy-3-methoxy-5-(all-trans-polyprenyl)benzoate + H(+) = a 2-methoxy-6-(all-trans-polyprenyl)phenol + CO2</text>
            <dbReference type="Rhea" id="RHEA:81179"/>
            <dbReference type="Rhea" id="RHEA-COMP:9551"/>
            <dbReference type="Rhea" id="RHEA-COMP:10931"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:62731"/>
            <dbReference type="ChEBI" id="CHEBI:84443"/>
            <dbReference type="EC" id="4.1.1.130"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="8">Cofactor biosynthesis; ubiquinone biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of a multi-subunit COQ enzyme complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Mitochondrion inner membrane</location>
            <topology evidence="8">Peripheral membrane protein</topology>
            <orientation evidence="8">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the COQ4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.130" evidence="8"/>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5082471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H7L2"/>
    <dbReference type="OrthoDB" id="417037at2759"/>
    <dbReference type="UniPathway" id="UPA00232"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031314">
        <property type="term" value="C:extrinsic component of mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120539">
        <property type="term" value="F:4-hydroxy-3-methoxy-5-polyprenylbenzoate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03111">
        <property type="entry name" value="Coq4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007715">
        <property type="entry name" value="Coq4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027540">
        <property type="entry name" value="Coq4_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004853">
        <property type="entry name" value="Sugar_P_trans_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12922">
        <property type="entry name" value="UBIQUINONE BIOSYNTHESIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12922:SF7">
        <property type="entry name" value="UBIQUINONE BIOSYNTHESIS PROTEIN COQ4 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05019">
        <property type="entry name" value="Coq4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03151">
        <property type="entry name" value="TPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="6 8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1 8" id="KW-0831">Ubiquinone biosynthesis</keyword>
    <keyword evidence="4 8" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="40"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="78"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="157"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="186"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="219"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="280"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="Sugar phosphate transporter" evidence="10">
        <location>
            <begin position="20"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="463"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="464"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="467"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="479"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF03151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAG5082471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="558" mass="63078" checksum="A263302F8678FB8B" modified="2022-05-25" version="1">MQVSEHAMWYRVSSALFYGIASFLITVINKTVLTTYNFPSFQVLGLGQMVSTIIILYVAKKLHYVDFPNLEASTIPKIFPLPIIYIGNMIFGLGGTKQLSLPMFTALRRFSILMTMVAEYYMLSIKPPMPVQLSVHTMIIGAVIAACDDLAFNLEGYIFIFVNNIFTAANGVYTKKKLNSKELGKYGLMYYNSLIMIVPLTLVAWWTGDINKAMQFNHWTNLLFILQFSLSCIMGFILSYSVLLCTFYNSALTTTIIGCLKNITVTYLGMVVGGDYIFSWWNFIGLNLSVVGSLMYTWITFKPKDIVEPKYSPIVTTPSTLLRRYSTAGGNEFPEFYTKNHVELTSLQRAVLAGGSAIVSLIDPSRGDMIACLGETTGVQALKYCQQRMLLSPEGAKILADKPRINTVTVDFSKLKELPDGTLGKTYYDFLVINQVSPDSRDNVKFIDDPELAYVMQRYREVHDIFHAVLLMPTTMLGEVSVKWVEALQTKLPMCIGGALFGAARLRPRQRKLYVKHHLPWAINTGKKAGFLLNTYFENRWEQSLDDFHKEMNIQRLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H7M5</accession>
    <name>A0A8J2H7M5_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Olfactory receptor 18.17</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HICCMSTLAB_LOCUS3423</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5081964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H7M5"/>
    <dbReference type="OrthoDB" id="6617147at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005549">
        <property type="term" value="F:odorant binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004984">
        <property type="term" value="F:olfactory receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004117">
        <property type="entry name" value="7tm6_olfct_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21137">
        <property type="entry name" value="ODORANT RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21137:SF35">
        <property type="entry name" value="ODORANT RECEPTOR 19A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02949">
        <property type="entry name" value="7tm_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0552">Olfaction</keyword>
    <keyword evidence="8 11" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="9" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="36"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="258"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="294"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAG5081964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="391" mass="45215" checksum="5215C77C20169EDE" modified="2022-05-25" version="1" fragment="single">IAHQDQKTLKKGYKIFKWTKKISTVIGLWPLSQNPFLFTICTVYYIIYVVLALLDMYKSFDNTDELVDNVTESMAVIYIYFRILFLRVNISSLGEIYSQVFKDYNVKDFENSQEIEVFMQFINKGIFLVRGFASFMIGTEAVWYFSSLAATPEFFIDDNNQTIFIIPYKLYFFHEINSLTRYYLTFLCIMPSIWAFGFGYVSVDSTLISLLFYISGKMAVLTMRIDALENGPNSRKKLNKIIAEHCKLLKMGDGVKDAYSGGLLVYLVNTNVIICIVGYQMLITFMAPGREADFFRYALYMGEMYMLLSIFCMISEHLTAESLKCCEAFYNCQWYDLPIDCKKDLIYCIERSQKPLALTAGKFTIFSNVTMTNVTKAAMGYLSVLRNFLDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H800</accession>
    <name>A0A8J2H800_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cc_p33_2b</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS3794</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5083291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H800"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="186"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5083291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="217" mass="26381" checksum="C960D3BC0AE25F2C" modified="2022-05-25" version="1">MDNTSKEENTVLHSRQMPEDNYKKNIKNNSEENNNHEFHYKATLLRHTYNLNPETINKLQENFKTYLNIFLAYIRTDKSESSDFFQRVTLGRFFKKLLMLIKFIIHPINRDESLKRLNDMNDVTLCNRMLYEECRKFFGLTKDFLLEPKKFEQEEWSLNEWGKNYWNFLHALSILVQYENKYKDKALFQIIMIIISGSRLLIFFFNKKKNSIYKIRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H874</accession>
    <name>A0A8J2H874_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS3931</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5083796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H874"/>
    <dbReference type="OrthoDB" id="2142040at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006616">
        <property type="entry name" value="DM9_repeat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31649">
        <property type="entry name" value="AGAP009604-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31649:SF1">
        <property type="entry name" value="FARNESOIC ACID O-METHYL TRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11901">
        <property type="entry name" value="DM9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00696">
        <property type="entry name" value="DM9"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5083796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="161" mass="16509" checksum="77E3D9DB42B930D4" modified="2022-05-25" version="1">MGVPPNANVSPSAPAELVAARSICWCDAAGGSMPPGAVEGGHDGEPLFVGRASHEGAMIPGKVKPSHGVCYVAWGGEEHGKSDYQVLCGCKPQWVATSGGNIPANAIPAGETEDGEPLFVGRVNHEGTVTIGKVQASHNVCYIAYAGAEVPFPEYEVLVGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H8K3</accession>
    <name>A0A8J2H8K3_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Endonuclease/exonuclease/phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS4222</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5084884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H8K3"/>
    <dbReference type="OrthoDB" id="419189at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="2">
        <location>
            <begin position="446"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="189"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="242"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="50"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="256"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="283"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5084884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="1143" mass="130977" checksum="F3DEDF3BFD8CC57B" modified="2022-05-25" version="1">MADLGDQIPTSFPSVTNSQTSPGITTSSNVSQIQIGSSSDTNNQALAGPRTSTNNDRSSTDTIKSLRAYMEENNNKCEENSTAITLIKSTLDSLAGPQNLPFLSQQRCSSQLLISGIPKDVSSKHTNVQTVNQIFDKLNVGNLIKVTTKLQKHPERDWKRLLHSDISEKVTKSNEIVYNSYHKKSAAKMVDGNATTSSKRKGNDSSDLNPVNKILRKNPININTEMFDSEFQKMIAKALNEKRNDKFQPNIKAKRQQSSQSASNADQKTSDGWQLPKHPARPQIQTETQVTPTGNKYSHLAKNTSNVEITDNLDNTEDNNDMEIAPDGEQEAATTNITVTAPKQKVQRSPPIIISEITIKDVIKLLCENNINKTEFRLKQVSPNNNITVSCNNLDTFVKVNKIFFDKQQQYYTYTPKSQKPKTIVLKGQSTDLPTVTSSSINILNLNINSYLAHSTQFQILVDELKPHIITVVETWLNPDNHITLADYTILRRDRGLINANGQYIRGGGVACFVHNSRKSKLLLSSESHDINNPEFMIIDITSPTGCHILLSSIYRRPQGQLLDSFFIQFSKYYPLYKNIIIIMGDLNCNLLKSDRPANHLKSFITESKLYCIPFGPTFHTTETDSWLDVIIVDCADKLNNYTKTVTPFIGGHDYLFCNYKFESKTAYEKLVKFRDFKNCDHQGLTRDLNQKLNLANINLEDTEPNLLVTHFINSVTTSLDRFAPFITRKLTRPKFRHRDNLYKRDRRTGNANLLTLYKKRRKDLKIKLKAARDAYFKQILEKATSQSNIWTSLKRMDIIKNKKFTPLDHFGAEELNKYYADIVSKHPSCSRDFIENPPSHVTRKVDSIFKWSQIDNVDVTKNLQMILSKSKGKSPDGLDLKWLRYHIPCISLYTKIIILGSNRKLRQLNNSHLPQIIIDGNTIPYVTYTKHLGIHLSNNLSWDAHVAHITRKVYGTLNCLKHRKNILSTSTRKLLITATIVPIIEYCSLVLIDSSKRLDYKLQRLVNNCIRFIYNLRREEYVTPYRESLNWLTIKTKRRYCLACFLYKIFKTDEPKFLKNLFIEEYPDIRRSDRIAAKSNNITFKIPSFSSTVYEHSFVISAIRLWRELPIELTDSFSLDTFKTTSYEFFSHQEREETRGDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H932</accession>
    <name>A0A8J2H932_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RNA helicase</fullName>
            <ecNumber evidence="3">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">HICCMSTLAB_LOCUS4305</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DEAD box helicase family. DEAH subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="3"/>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5085203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H932"/>
    <dbReference type="OrthoDB" id="5600252at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040029">
        <property type="term" value="P:epigenetic regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050684">
        <property type="term" value="P:regulation of mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19854">
        <property type="entry name" value="DSRM_DHX9_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19855">
        <property type="entry name" value="DSRM_DHX9_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18791">
        <property type="entry name" value="SF2_C_RHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.20:FF:000026">
        <property type="entry name" value="ATP-dependent RNA helicase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.20:FF:000028">
        <property type="entry name" value="ATP-dependent RNA helicase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000677">
        <property type="entry name" value="ATP-dependent RNA helicase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000284">
        <property type="entry name" value="probable ATP-dependent RNA helicase YTHDC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011709">
        <property type="entry name" value="DEAD-box_helicase_OB_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044445">
        <property type="entry name" value="DHX9_DSRM_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044446">
        <property type="entry name" value="DHX9_DSRM_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014720">
        <property type="entry name" value="dsRBD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF119">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00035">
        <property type="entry name" value="dsrm"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07717">
        <property type="entry name" value="OB_NTP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00358">
        <property type="entry name" value="DSRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54768">
        <property type="entry name" value="dsRNA-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50137">
        <property type="entry name" value="DS_RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0347">Helicase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="DRBM" evidence="12">
        <location>
            <begin position="3"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="domain" description="DRBM" evidence="12">
        <location>
            <begin position="171"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="13">
        <location>
            <begin position="335"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="14">
        <location>
            <begin position="576"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="80"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="526"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1096"/>
            <end position="1144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="537"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="1127"/>
            <end position="1141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CAG5085203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="1154" mass="129025" checksum="8E3845812CA83B25" modified="2022-05-25" version="1">MGDIKSFLHQWCTKNGKEPQFDVRPTGLKHRQRFLCELRVNGFDYVAVGNSTNKKDAQGNASRDFINYLVRTGHVAAKDVPGDIGPTGGMDAGAGPAPGPAQGQGPAPGPQRSVFQDGMGPNDIGQAYRPYNDRGESNYTYMDRIADQKRVEEAEDLDVNAAIHGNWTIENAKSKLHQFMQTNKINTDYKYTPVGPDHTRYGLRNLHITGRETASNKQTASKSCALSLVRQLYHLGVIEPFSGTLKKTRETQQMKPYPVKISPELMDKVYEVLNGLDVKPVDVRRAPMPEKVEPGTQNPESKPGISLVTDQDASLKQSMKERSTLPVFAKKNEIMAAINENPVIIIRGNTGCGKTTQVCQFILDDYIASEQGAYCSIVVTQPRRISAVSVSDRVAAERCEPLGQSVGYSVRFESQLPRPYGSIMFCTVGVLLRKLEGGLRGVSHVIVDEIHERDVNSDFIMVLLRDMVHTYPDLRVILMSATIDTSLFSDYFNKCPVIEVPGRAYPVQQYFLEDCVHLTNFVPPMDSRKRKSRDPDDTLPDAEPEENMNKFVSSDYSEHTKNAMAQLSEKEISFELIEALLEYIRRQGIPGAVLMFLPGWNLIFALMKHLQQHPVFGGNKYVIIPLHSQLPREDQRKVFEPVSPDVTKVILSTNIAETSITINDVVYVIDSCKAKMKLFTSHNNMTNYATVWASKTNLEQRMGRAGRVRPGFCFHLCSKARFNKMEQHMTPEMFRTPLHELALSIKLLNLGSIGKFLSKAIEPPPIDAVIEAEVMLREMKCLDSNDELTPLGKILARLPIEPRLGKMMIMGCMLRVGDALSTMAANSTTFPEVYNMGPDMRRLSAQQKWFAGARYSDHVAMLHAFQCWEEARGGGEYAEQAFCDSKGLSLPTLRVTWEAKNQLQGLLQTTGFPEETLCPTPLNYQAGADVRLDTITALLCMGLYPNVCYHKEKRKVLTTESRDALIHKTSVNCSNFEQTFPYPFFVFGEKIRTRAVSCKQLTMVSPIHLLLFGSRKVEFIDNVIRLDNWINLEMNPEQAAAIVALRPALESLVVRAAKDPETILELSPIEDKVLATIKELCGMNAGRFEMDAITGGGFQSRRPPRGHSTGFSGPPNKFTRDDNYRGGPRGGFGGRGGFRGRGWGDRGQRGYNRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H947</accession>
    <name>A0A8J2H947_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Similar to RMDN1: Regulator of microtubule dynamics protein 1 (Bos taurus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HICCMSTLAB_LOCUS4336</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5085299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H947"/>
    <dbReference type="OrthoDB" id="69711at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097431">
        <property type="term" value="C:mitotic spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005876">
        <property type="term" value="C:spindle microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16056">
        <property type="entry name" value="REGULATOR OF MICROTUBULE DYNAMICS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16056:SF16">
        <property type="entry name" value="REGULATOR OF MICROTUBULE DYNAMICS PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAG5085299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="289" mass="32255" checksum="E92D6EB3E7866B3C" modified="2022-05-25" version="1">MSSVRVSRVVVHRRVSEFPASSDWTTAPRGSDTRANSEPGAPWPENTCSACSCRSAGTVNACNAGACFTARSFLGTKVLAEHQIHCDVVSESYGWQDLIAPKYFPVKTLPAPLPIISLGLWGFAKKDDLDISSTKSRNALFAKVDALYENREYSKVRDILDQLRDSKDVEVLWRLARALYNMSKTASDVEAKKLIYDAYNLITEAAAIDDKHWAVPDSSFEEALQYLEAAEKADPLFYSHNLLLLGKTYLKLDRKDDAIKFLKMTAEFPAKNDDDQKAKQEASKILNSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H976</accession>
    <name>A0A8J2H976_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Similar to Tube1: Tubulin epsilon chain (Mus musculus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HICCMSTLAB_LOCUS4770</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the tubulin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5088235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H976"/>
    <dbReference type="OrthoDB" id="1662883at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.600">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.20">
        <property type="entry name" value="Tubulin/FtsZ, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="entry name" value="Tubulin/FtsZ, GTPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004057">
        <property type="entry name" value="Epsilon_tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008280">
        <property type="entry name" value="Tub_FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000217">
        <property type="entry name" value="Tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037103">
        <property type="entry name" value="Tubulin/FtsZ-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018316">
        <property type="entry name" value="Tubulin/FtsZ_2-layer-sand-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023123">
        <property type="entry name" value="Tubulin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017975">
        <property type="entry name" value="Tubulin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11588">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03953">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01519">
        <property type="entry name" value="EPSLNTUBULIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01161">
        <property type="entry name" value="TUBULIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00864">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55307">
        <property type="entry name" value="Tubulin C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="Tubulin nucleotide-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00227">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2 5" id="KW-0493">Microtubule</keyword>
    <keyword evidence="3 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubulin/FtsZ GTPase" evidence="6">
        <location>
            <begin position="74"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAG5088235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="442" mass="49569" checksum="CD3B81511737798B" modified="2022-05-25" version="1">MSEFICVQVGQCGNQIGSAFWPLALHEYGIETSSGGVNQLKFQKDHKKNIDDLADAFHSFFYVPDNSGKFSFKRISDLNSAKVKARAVLIDMEDSVVSRYKQGPLRNLFDQTCTVTNYPGSGNNWAVGYYTHGRNYHDKLEETIRKTAERCDSLHGFLLTHSLGGGTGSGLGTATLSLLADEYPHVDKFLSSVHPAAAQDVITAPYNVLLASKELIDHATCVFPADNGALLDICNSQICKKDNVDQLNYNVTSTNLVPYPQLHYIFSSVSPISMTAPKLTITKKTKVQDELFMNAWSRSHQLIKLDPLNPKSVIISAGHIARGNCSMDDMIRNIQRFQNKAKFTPWSKEVMKIGLCNVPPAGHPASLLCLLNSTSMRLMLKNIINQFDKLYQRKAHVHHYLEVDGFEAEHFDEAKESIKVVCDRYREVERQMPHNISRLKVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H981</accession>
    <name>A0A8J2H981_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RNase H type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS4786</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5088280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H981"/>
    <dbReference type="OrthoDB" id="7701509at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09276">
        <property type="entry name" value="Rnase_HI_RT_non_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5088280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="633" mass="72635" checksum="CD175150E04E1512" modified="2022-05-25" version="1">MASLRTLIDTLCPLWAKGPTPNVVSPFGDQFLDLPFSREELDFAIDNLKTKSSPGPDGIDYKMIMELPEEDSVQACKSIELVMEKICVHLEQIGLDLSVPKTKLCVFSKKRKDFANRDNWKVKVKGADVWHDEAVKFLGLWLHSELKWSNHIKELEKRCRNASKTINCLRGTWWGADPSLLLRIYRALIRSRIEYGGLVFFNLTKSDGKRLDRIQGKCLRAVLGYTSSTPLKICLCEAGELPLHLRFKQLAYNFLSKAFSRQNHKVLNTLQDIIDHEDNPVIINREGTIPLVDAFREVSRHSHLINAYSSPTCYAIDYESVFFHPNVSFKEGEEIVDINCRERNCQELFGEIFHEYLDAWTCYFTGGSKSDKSPFGGFAVVELSESIELKFRAPKFASIFTLEALAIFEAINLIGKSRWKCSVIFSDSRSVLQALASDSNLNNKSYLVFLIRNRIRDLMLAGKNVKFTLWDNCRVAKEAILTGRDTSLGLPSSDLNAVWKNNNRKEFIEWFSCTDPDKGIFYTSNFASFNPKPWFDKLKVNRRTIVSINRLRSGHTSLRASLFKYNIVHSPTCLCREYEETPNHIFFQCSRFDEPRRSFFKSLQDVLGVGPYCIESLLHCLSHEIVRFLKNAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H982</accession>
    <name>A0A8J2H982_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to GIN1: Gypsy retrotransposon integrase-like protein 1 (Rattus norvegicus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS3631</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5082703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H982"/>
    <dbReference type="OrthoDB" id="7695408at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="2">
        <location>
            <begin position="527"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="109"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="178"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="435"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="745"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="113"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="183"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="441"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="467"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="752"/>
            <end position="771"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5082703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="1250" mass="138477" checksum="46F4B398C40B8F13" modified="2022-05-25" version="1">MFPRTPVIRPSAPVTSISNVIEQNNLDPLYPILSPPTNDDLLHPENSQSRVMNSTANPAVDPGNVSTAHVSGIQPLAESESANSSTQVLQGVIQQLRAEIQAMRAAQQGLPPTCTSTTSHTNTIPLNSNVPPVDSFGNNLTFYPRELFPVSNMQPTPQPPPPGIPPYFYPPPQALNGAASLPYAPPPVPLPRPTLPPQSTVPPAQTMSAPPPGPPVYFYTPVPHVLQQNTLPYQHTYIAPRHSTAPVPTQSWQSTNTTLRLNDICRTAKSWNITFPPRDASVKLDAKKFLTVMEQRMDSNDIPIDHFRSVITTTLTGHILEWYYQNEHLFINWQTFKEHFKIWQTHHSDEALLQEIFSLQQGDEELGISFINRMQCSFAQLEEPLPENRQVRIIIQKFNFQFLSKFAEEPINTYSLLYKRVSAWQSVIDAGRRNRTELTANNKSKNQSSNNSSKPRTKINAVTDSDPLIRDNPDTVTKNDERTILDAITGPPNPHFSPKKDSANPSTLTTADLQAIVQPQGYIGTRPPTQPWTIISIDTIGPYTKSSSGHQYALVIEDIYTRYLEIFPLRQQTGKEIVKHLRNALCHWGPVRQIISDNALWKARIDRMDELRHFVERYMLKARERTRKQHEKRFSTQLIDLKIGDQVYYLNKRLSKKVDGYSAKLAPKYAGPAVITEIVSPLVVKLADSAGNSLGTHYLNDLKLPRRSKRHPLSQITSENTSIMSLSVTPESLNRESLISGSSTETLYNNKTSSHTHTPHSFPSLSLPPTTTSTKIQTSEIITQLDFSLIPKPAAVKFDASNVIQKPKETNSVNSKVNFRTETSPSPITEPEKLSTLYSRFEEPAAQPPIWVSELLDSINELHTETRENTVEIQSLQKNIQTVEKHLSSLQHQQLANLSSYVREVTHSVDTINHRFDVIEPKMQLIDQEPQPIAEPVAAKFPEQVPEHQPTIYDAGSTPNNKAVTPVLASQLASACGPNARLKIRRETSKPSPKGAKFPPSPFLTHLAARGELPAEQVRAHVATGAIKETTPVKPVMITYATTLPYSQTVSAPKYNVSISPTAAFQQFLKDTEAELTAQTTITSGAVAKIVECPSNFSIRSVDIAINAGLVIRPSAPVTSISNVIEQNNLDPLYPILSPPTNDDLLHPENSQSRVMNSTANPAVDPGNVSTAHVSGIQPLAESESANSSTQVLQGVIQQLRAEIQAMRAAQQGLPPTCTSTTSHTNTIPLNSNVPPVDSFGNNLTFFFFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HA55</accession>
    <name>A0A8J2HA55_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="2">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HICCMSTLAB_LOCUS5294</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="2"/>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5089582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HA55"/>
    <dbReference type="OrthoDB" id="10014838at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000013">
        <property type="entry name" value="E3 ubiquitin-protein ligase MGRN1 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045194">
        <property type="entry name" value="MGRN1/RNF157-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058981">
        <property type="entry name" value="MGRN1/RNF157-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22996">
        <property type="entry name" value="MAHOGUNIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22996:SF0">
        <property type="entry name" value="RE60872P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26192">
        <property type="entry name" value="RNF157-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13920">
        <property type="entry name" value="zf-C3HC4_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="10">
        <location>
            <begin position="261"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="382"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="431"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="448"/>
            <end position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAG5089582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="529" mass="58601" checksum="01495ED99EEAC7B8" modified="2022-05-25" version="1">MGSLTSRQNAGVEEVDIVSNHAYKYPPRSGNYFGSHFIMGGERFDTPQPEAYLFGENADLNFLGSRPTPFPYPPPQANDPTKTLKSLVNIRKESLRLTKSIDPVPTSSESNDTINAIKNFGEGDVDKKTTRYVPRDSSMNSETYHYKKGANQQFIQTSHVFDPSLYNEEDLLYNTDREIVPMAIHCVAEEGTEEPKQSHTTIAVVEKQSDGSYILKALKQKLYVDGLCYLLQEIYGIENKNTENTKQQGSDEDAEDNGSECVICMCDVRDTLILPCRHLCLCYGCADSLRYQANNCPICRAPFRALLQIKALQKATGAIISNPPMPEGSCENIPSGYEAVSLIEALNGPYTPRVVVPAPESPDTPDTDTASAIQAAEILNRSAERTPVSKHTGLKDGETGAAIARSSNVTPCPTPEFRMSVLLARDETVVNQKELHGRSPGMRAKISHPREKNSIRTRDTLRLVNEKQPHYDVQGQDEDSEAEKLSPLLDSAASTDPRESHHRICDLDIDDEMTSNVNENDSEINCNSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HA69</accession>
    <name>A0A8J2HA69_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS5469</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5090044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HA69"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5090044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="172" mass="20001" checksum="0AA73A08B44F240C" modified="2022-05-25" version="1" fragment="single">IGILKRVSFSTKSDIGNKIFHHRLRSFHHQREHLLQFSASKRRSYFAPQVLPGRIFQPKQIPHSNAVFLLGPSEMSVGKIIKVTDQNLLDYLRVPQQKTWLVKNVETDIRRVLKRLAVNFSQVESWSGAEQNSIFEITKNYVCSLQLLHTASFPVAYSVKTVEINNKYKCYW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HA84</accession>
    <name>A0A8J2HA84_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">EGF-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS3981</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5083973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HA84"/>
    <dbReference type="OrthoDB" id="504708at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39069">
        <property type="entry name" value="ECDYSONE-INDUCIBLE GENE E1, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39069:SF8">
        <property type="entry name" value="FI17111P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EGF-like" evidence="1">
        <location>
            <begin position="136"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="1">
        <location>
            <begin position="176"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="1">
        <location>
            <begin position="225"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="1">
        <location>
            <begin position="259"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="1">
        <location>
            <begin position="301"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="1">
        <location>
            <begin position="384"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="1">
        <location>
            <begin position="508"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="1">
        <location>
            <begin position="550"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="1">
        <location>
            <begin position="625"/>
            <end position="667"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5083973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="676" mass="75574" checksum="E1CB92ED90B901C7" modified="2022-05-25" version="1">MDISQVILKATCGNDDDCNDIKHAKCSDDKDCTCIVGYSSVNKTYCAPSLNSFCWRDEKCAADHASCIDSQCQCDEDYLQHSHNECLLKLIGSSCKDNSECSRVKYAQCSAGNICVCSINTKSVDQALCLPVLNEYCKTNDDCKVENSICIDNKCQCKPNYMTLLNECQAPYLGMPCINSKNSCRFINHSICLDDRECTCLPNYLPVNNNTCLPAYNQICFNNEECATKNSVCVNYRCKCKPYYIYRQVQCVSAYLRQWCQKEEDCSGVKFATCSKDNICVCKRNYFQSDDSNCSPLLKSSCSTTEDCIVANSVCQDGKCKCGESFFAKSNDRCAKISLVQTCSTFYDCLTIPHSDCSKIGLCYCDLGYVSIDGIRCVPALGQFCTKSKPCGINNSDCIDNKCQCKPYFEEARDSECIPINFNKSCSFDIDCRDIKHSMCFYGECTCKQNYAPVNFQTCVLLLGGVCSTNEDCYYVKNSVCVSNICICDAEHLTVSNNKCEPNMLGTLCLTNDDCDNIDNSICSADNVCTCNLNYRALEKFLCEPMLNGFCSEDSQCPTDSFRCVDHQCQCQPNFTAMSASQCFETNLINTCTNVTECSDSWHAQCTSDHKCVCDLNNMALNPSTCLPILNGFCWRDHQCMAENSVCTDYHCACKPNFIAVARNLCIPDRRKIHLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HB25</accession>
    <name>A0A8J2HB25_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glutamine-dependent NAD(+) synthetase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">NAD(+) synthase [glutamine-hydrolyzing]</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HICCMSTLAB_LOCUS5573</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5090291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HB25"/>
    <dbReference type="OrthoDB" id="2020662at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004359">
        <property type="term" value="F:glutaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003952">
        <property type="term" value="F:NAD+ synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD+ biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003694">
        <property type="entry name" value="NAD_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23090:SF9">
        <property type="entry name" value="GLUTAMINE-DEPENDENT NAD(+) SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23090">
        <property type="entry name" value="NH 3 /GLUTAMINE-DEPENDENT NAD + SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CN hydrolase" evidence="4">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00017309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00030681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAG5090291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="280" mass="30657" checksum="74A1AFE174375280" modified="2022-05-25" version="1">MSLDGVKIISNSSGSVFVIRKAHMITDRVKSATAKAGGVYMYSNLRGCDGGRMFFNGSSSVSLNDEIVTAGKQFSLAEDEVTVATIDLEDVRTYRNNIRSRTHSAARSNPYPRVKVEFSVCDNGPFKLTNDMMDAKNLDRKEVGEFHTPEEEISMAPACWMWDYLRRSCQGGFFLPLSGGVDSSSTACLIFSMCNMIVDAVKDGDNQVLADVQKIVGDFTYVPKDPKQLCNTLLVTCYMATENSSSETKARASELASEIGSYHHSIIIDTAVSAVLGIFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HBP7</accession>
    <name>A0A8J2HBP7_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to abhd12: Lysophosphatidylserine lipase ABHD12 (Danio rerio)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS4215</name>
        <name evidence="4" type="ORF">HICCMSTLAB_LOCUS6871</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5084855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5093481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HBP7"/>
    <dbReference type="OrthoDB" id="10249433at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047372">
        <property type="term" value="F:monoacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004622">
        <property type="term" value="F:phosphatidylcholine lysophospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052651">
        <property type="term" value="P:monoacylglycerol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006660">
        <property type="term" value="P:phosphatidylserine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12277">
        <property type="entry name" value="ALPHA/BETA HYDROLASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12277:SF194">
        <property type="entry name" value="FI04476P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="127"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5084855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG5093481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="358" mass="41346" checksum="A2A8D8E399B2127D" modified="2022-05-25" version="1">MQWIYLLAGFVPFVILDIWYMGIAALWTIKIIIITYIIIFGICPFIFHYSYSFQRKILFLNFVHWPPSLDFERPESIGLEGVRNFYLHTDENVKIGAWQMLPRSLLNDSTILNDEYFEATLANASKPVFLYMHGNSGNRGSSHRIELYKVFQDLDYHLIAFDYRSYGDSDPAELSELGVVTDSKYVVRWLMNKVNNSAPVFVWGHSLGTGVSCHALDLLAAENIHPAGLFLESPFNNIADELRCHPFAQIFRHLPWFDWIIVQPFYGNNLRFESDKHSANIKCPIMILHAEDDSVVPFNLGEKLYEDTLKSHGNDTEQVQMVRINASLELGHKYICRYKPLPSIIQNFVLQSVKNQVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HBR6</accession>
    <name>A0A8J2HBR6_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similar to TRIP4: Activating signal cointegrator 1 (Homo sapiens)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS6516</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5093005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HBR6"/>
    <dbReference type="OrthoDB" id="338816at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06554">
        <property type="entry name" value="ASCH_ASC-1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.130.30">
        <property type="entry name" value="Hypothetical protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039128">
        <property type="entry name" value="TRIP4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056993">
        <property type="entry name" value="TRIP4_3rd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12963:SF0">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12963">
        <property type="entry name" value="THYROID RECEPTOR INTERACTING PROTEIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23134">
        <property type="entry name" value="TRIP4_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Activating signal cointegrator 1 third" evidence="1">
        <location>
            <begin position="21"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF23134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5093005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="273" mass="31487" checksum="DC4FA0DB12D4CDA1" modified="2022-05-25" version="1">MLIAGRLSLAREIANFRDGCSDYYQSTDSVWLSNKERAEIQKHQEEIRSRKHASRLSKKVTLDLYGRQVIDEPENYDNLPLPQQSQAQSFNDVVCPDLEFELPQYVETNNILKNISNNSNASTTIRRIQDKELLDMVDEGYCLSMHQPYASLLVAGIKIIWYSAHRGRLWIHAAAKVVSKEEITALEDHYKNFNENYIFPKTYPAGCLIGCVTVVDVLPQDEYRKIYPDGDSDSPYVFICQDSRELSLKFPMQGKHKIYKLDKQIHKAALKHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HBW5</accession>
    <name>A0A8J2HBW5_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS6283</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5092651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HBW5"/>
    <dbReference type="OrthoDB" id="7694116at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5092651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="84" mass="9938" checksum="2CC6043D20C904D0" modified="2022-05-25" version="1">MNSTYENDRKLQRSLHSSVLCALFLQIYLRDLFIEDDSVRRSERFAAKRNNINFKLPNVTTTQYENSFAITVIRLWEQLPADIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HCG4</accession>
    <name>A0A8J2HCG4_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Integrator complex subunit 14</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HICCMSTLAB_LOCUS7221</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the Integrator subunit 14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5093895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HCG4"/>
    <dbReference type="OrthoDB" id="2374335at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032039">
        <property type="term" value="C:integrator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034472">
        <property type="term" value="P:snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00198">
        <property type="entry name" value="vWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.410:FF:000140">
        <property type="entry name" value="Uncharacterized protein (Fragment)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039841">
        <property type="entry name" value="INTS14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045814">
        <property type="entry name" value="IntS14_b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046471">
        <property type="entry name" value="IntS14_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13532">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13532:SF3">
        <property type="entry name" value="INTEGRATOR COMPLEX SUBUNIT 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19435">
        <property type="entry name" value="IntS14_b-barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20504">
        <property type="entry name" value="IntS14_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13519">
        <property type="entry name" value="VWA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VWFA" evidence="5">
        <location>
            <begin position="2"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00061449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAG5093895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="483" mass="53500" checksum="17D8240E2AB00046" modified="2022-05-25" version="1">MPTVIALDVSLSMRRPVISTGIDASQNEQLTRHHLAVQGIHTLLNYLQVNSKLEFVSLVVFSSLYELICPFTRDYDSIRSRLQMIEERDKTCIETALHGVNSVIMSEWGNSTACQVILITDGNPGVGAMSLGHSLKSLHVARENPFPLPFPFPGKLSVVCIASQQDAGLSQGLPLYQKLVDLAGEDSGVLVPEGSLSKTSVNNCFQKLAETNYVSFQGYLKCGNLGSRIHLSPAPMSYTKRTDFELVPGMTISKTIEICGFISVSDVGSPNSISRHLVLPLPTEKTPSMQGVVSLEEESDAEDTSDEGKFASFCVLLHGALKVENMAALCLLQTDWYGFIYSWADTKKKSNLMLTVLEPGAYVVPWLGNFNHLGPADVVSKNVEVLAFPIKPTEKRSYSQNAPSWIRQVGLQSDIQKILRHARKLPEKTQNFYKRECTLLPTNLHYDCAIQMGHVANMLRKPFSRELKNNITPIKSAKFHQDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HCY4</accession>
    <name>A0A8J2HCY4_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS6297</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5092665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HCY4"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5092665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="156" mass="16958" checksum="553530392D8BAF86" modified="2022-05-25" version="1">MGKRKNKETIEQIVKKLRTDKEQSNDNEGEASSKTHEVDPTQESISSSDSEHELPEQTEDDGKADEAKDDKENEAVLSEEEDLPEELANILGEDPSKLKAFEAPKINTAIEAKLSASAKKRDTFRVEAQNSIGSAVMAVGAVASTLISETESIDPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HDT6</accession>
    <name>A0A8J2HDT6_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Similar to Mvl: Protein Malvolio (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HICCMSTLAB_LOCUS6369</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NRAMP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5092785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HDT6"/>
    <dbReference type="OrthoDB" id="409173at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015086">
        <property type="term" value="F:cadmium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005381">
        <property type="term" value="F:iron ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005384">
        <property type="term" value="F:manganese ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00221">
        <property type="entry name" value="NRAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001046">
        <property type="entry name" value="NRAMP_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01197">
        <property type="entry name" value="nramp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF037982">
        <property type="entry name" value="Nramp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11706:SF33">
        <property type="entry name" value="NATURAL RESISTANCE-ASSOCIATED MACROPHAGE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11706">
        <property type="entry name" value="SOLUTE CARRIER PROTEIN FAMILY 11 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01566">
        <property type="entry name" value="Nramp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00447">
        <property type="entry name" value="NATRESASSCMP"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="107"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="182"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="209"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="254"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="298"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="361"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="418"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="449"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="483"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="512"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="31"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAG5092785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="594" mass="65579" checksum="F2F1D1B1F7E83469" modified="2022-05-25" version="1">MTDNDSIGNYGGSSNDNAGSPSKRVDKKSQEQNNLKYNEGSTLTSGGDQTYFADTKIQIPELDNNFFSLRKLWAFTGPGFLMSIAYLDPGNIESDLQSGVKAKYKLLWVLLSATILGLVMQRLSARLGVVTGLHLAEMCYRQYKKLPRILLWIMTEIAIIGSDMQEVIGTATALYLLSNKGLPLWAGVLITVIDTFTFLLLDKYGLRKLELFFGLLISIMAVTFGYEYVKSAPPQLEVLKGMFTPMCVDCDSTVLLQAVGIVGAVIMPHNLYLHSALVKSRDIDRRQPTKVKEANKYFFIESCIALLVSFIINVFVVAVFAHGLFGKTNADVYEVCVSTNNTLGMDTFKTRNNTNLVEADLYIGGIFLGCTFGAAAMYIWAVGILAAGQSSTMTGTYAGQFAMEGFLNLQWSRWKRVLLTRTIAIVPTFFVAFYASIEDLTGMNDVLNAVMSLQLPFATLPTIAFTSSVHVMGQFKNGKFNKIVATALSAVVIAINIYFVKDTVETHLPDNWAVYLGITIYAIFYLGFCFYLIIHMAIAMGADFLTNYRLIAKYIGGPSEMNFALSNPADYSRTNYGFAIQESINGSFSSLDVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HDV7</accession>
    <name>A0A8J2HDV7_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Similar to Homeobox protein Hox-A2 (Notophthalmus viridescens)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HICCMSTLAB_LOCUS5560</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5090260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HDV7"/>
    <dbReference type="OrthoDB" id="7549742at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020479">
        <property type="entry name" value="HD_metazoa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000047">
        <property type="entry name" value="HTH_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45664:SF12">
        <property type="entry name" value="PANCREAS_DUODENUM HOMEOBOX PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45664">
        <property type="entry name" value="PROTEIN ZERKNUELLT 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00024">
        <property type="entry name" value="HOMEOBOX"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00031">
        <property type="entry name" value="HTHREPRESSR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 5 6" id="KW-0371">Homeobox</keyword>
    <keyword evidence="4 5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="7">
        <location>
            <begin position="100"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="5">
        <location>
            <begin position="102"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG5090260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="371" mass="42488" checksum="17195F1C50F53643" modified="2022-05-25" version="1">MATFFCNSGLNQEVFNNCGSEINQVIPSAELGVNPIMEFLVSENANCNYLTFNHGESFNHQKMIDQSSASTLNESDATCKVLDRESSTCKRRSSVKKEFNSKRRERTAFTNDQLLHLEKEFITQGKYLCRPKRIEVARDLGLNERQVKVWFQNRRMKDKKTGSVKDDKNEEKDLKTALPSTRIGCRKRHVEFKKEKTYQNTSLFASVPDPASALVIYGENQMHALNYSNYSPSDIHHHQLSSWNLNNRINYDMIQNPNYDNFNGPDGCIVGNSHPAAIYSDSYNWNYNLNNEHCSIPNGYANEIKAEETFYGHYPNDYIPNNDNHYPPGCNNQNADLNSNYSGSSPQSFDFNGFDDILVNDCSYLFSMVNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HE01</accession>
    <name>A0A8J2HE01_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cadherin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HICCMSTLAB_LOCUS5651</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5090486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HE01"/>
    <dbReference type="OrthoDB" id="6379298at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.60">
        <property type="entry name" value="Cadherins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002126">
        <property type="entry name" value="Cadherin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015919">
        <property type="entry name" value="Cadherin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020894">
        <property type="entry name" value="Cadherin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050174">
        <property type="entry name" value="Protocadherin/Cadherin-CA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24028:SF328">
        <property type="entry name" value="CADHERIN-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24028">
        <property type="entry name" value="CADHERIN-87A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49313">
        <property type="entry name" value="Cadherin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00232">
        <property type="entry name" value="CADHERIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50268">
        <property type="entry name" value="CADHERIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 8" id="KW-0106">Calcium</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Cadherin" evidence="9">
        <location>
            <begin position="101"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAG5090486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="245" mass="27955" checksum="55A0370DE3E24CB1" modified="2022-05-25" version="1">MDTLSLILSHIPDESEPLITTFDKGSNYLLGAELKYQNGQWEVCITKKQDYEVQTMRNYENYEDSLTTILEVIDMPDELPKWARLTASETLKEKSTHTFIVTAVDGDIQINAEINYKIQVLDKVNATIIVIIEDINDHEPEILPEMLSITIKEGKYTTLEFEQPVMITDPDLIQATEVANQSHVGRRIVSIDLENLNDEFPIFENNSLTVSIPEDVENNHYICTMLATDRDVNDTVKYSLKTPSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HEE3</accession>
    <name>A0A8J2HEE3_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Similar to lsm12a: Protein LSM12 homolog A (Danio rerio)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HICCMSTLAB_LOCUS6458</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LSM12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5092939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HEE3"/>
    <dbReference type="OrthoDB" id="1057137at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01735">
        <property type="entry name" value="LSm12_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047574">
        <property type="entry name" value="AD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039683">
        <property type="entry name" value="Lsm12-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019181">
        <property type="entry name" value="LSM12_ABD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048478">
        <property type="entry name" value="LSM12_LSM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13542">
        <property type="entry name" value="LSM12 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09793">
        <property type="entry name" value="AD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21166">
        <property type="entry name" value="LSM12_LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00995">
        <property type="entry name" value="AD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52001">
        <property type="entry name" value="AD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sm" evidence="4">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="domain" description="AD" evidence="3">
        <location>
            <begin position="80"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="178"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="179"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="190"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS52001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAG5092939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="199" mass="22277" checksum="E0565ECCAB380DF9" modified="2022-05-25" version="1">MAGVSDWFSIGSTVACKTCYKKDIEGEVLAFDPQTKMLILKCPSSSGRPSVHDVNIVNLSLVSDVQVKREVSPTTTEPPQSLNLQRLNTRVRNQVEEKKRMVKALQAGVSPEGQKLFIAIAKTIQEITWSGQDIVVWDNVTIRPPYKVDNVHGNTESKPYLHVRKVVEKHMKDTAAAEIQQQSQQQPIQKNNSNTTLQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HEF2</accession>
    <name>A0A8J2HEF2_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Histone H2B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HICCMSTLAB_LOCUS6473</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the histone H2B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5092954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HEF2"/>
    <dbReference type="OrthoDB" id="10036121at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22910">
        <property type="entry name" value="HFD_H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000016">
        <property type="entry name" value="Histone H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000558">
        <property type="entry name" value="Histone_H2B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23428">
        <property type="entry name" value="HISTONE H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00621">
        <property type="entry name" value="HISTONEH2B"/>
    </dbReference>
    <dbReference type="SMART" id="SM00427">
        <property type="entry name" value="H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0158">Chromosome</keyword>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="12">
        <location>
            <begin position="17"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00017644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAG5092954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="128" mass="14509" checksum="5A2C2453F40DA59B" modified="2022-05-25" version="1">MPPKTSGKAVKKSGKAQKNITKSDKKGRKKKRKESYAIYIYKVLKQVHPDTGVSSKAMSIMNSFVNDIFERIAAEASRLAHYNKRSTITSREIQTAVRLLLPGELAKHAIYLYVNNMYLFDICDLGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HF23</accession>
    <name>A0A8J2HF23_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to Rmc1: Regulator of MON1-CCZ1 complex (Mus musculus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS8841</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5097715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HF23"/>
    <dbReference type="OrthoDB" id="26384at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035658">
        <property type="term" value="C:Mon1-Ccz1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010506">
        <property type="term" value="P:regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040371">
        <property type="entry name" value="RMC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009755">
        <property type="entry name" value="RMC1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049040">
        <property type="entry name" value="RMC1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12897">
        <property type="entry name" value="COLON CANCER-ASSOCIATED PROTEIN MIC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12897:SF4">
        <property type="entry name" value="REGULATOR OF MON1-CCZ1 COMPLEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07035">
        <property type="entry name" value="RMC1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21029">
        <property type="entry name" value="RMC1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101898">
        <property type="entry name" value="NHL repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Regulator of MON1-CCZ1 complex N-terminal" evidence="2">
        <location>
            <begin position="36"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="Mic1" evidence="1">
        <location>
            <begin position="372"/>
            <end position="618"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF21029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5097715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="655" mass="73830" checksum="62CA21636A16F9D5" modified="2022-05-25" version="1">MATAETKDDEAGNDNYYLELSVNPVRFESLTCVNNVFFDDFKHQVFAVRSGGVTTVTGPSDVFTFKMEDKGQVISIKFSADMNVLAIQRTYTSVEFVNYNPGTGLDVVEYSQACKSKNATIQGFVWTHGNEILLITDHGVELFSVNPAKRSVKALKSLSLGVNWYVYCPRSNMILLSSGTIGNQMQALHITPGNLHKITKFEMEAIPAKPGKLAVSDRDVVLAVLYGTPCIIVLRHQYEANKSISAYVCVYTVHKFAINVVDNLIIVHHQASKTSMIFDIMLGGVSDGTVMHHTSVAIPKPIKPYNLKVQGATLSEQVIQPCPLYSENWVVFQPNIIIDIKLGCLWYIELQLEALVKLINDKVQLVEFIIQRKDAKPILLQVLQNYVNDLPMTLIDIPAIFDKIDSVYRGHLENEIQSQMGTPPQNVSKNTETFDDLSYKLLLDQSDMYTHILSKFSADLIEPKMVVWVLLEYIRSLVEHGIPVQHFIYELVITTLVQRKAYYQLHQLLQYHVVADSKPLACLLLSLENLYPAAHQLALDMLKRLGSAHEEIIEVLLSKGHILPALRYVRSVGMADQVSARKFLEAAKALNDPTIFHSVYKFFEQRNVRLHNTTAFTRGEHCQSYVQHFEHLFRGNDGVLNTSFNSSMSTISLQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HF96</accession>
    <name>A0A8J2HF96_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">CYP12K3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HICCMSTLAB_LOCUS7399</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5094073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HF96"/>
    <dbReference type="OrthoDB" id="3945418at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050479">
        <property type="entry name" value="CYP11_CYP27_families"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24279">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24279:SF120">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0349">Heme</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG5094073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="162" mass="18537" checksum="4D0F1D848C3F6009" modified="2022-05-25" version="1">MVTKLYISRLKSPKSINGLLLKKNYASIGTCPVQNEELSWEEAKPYNEIPGPKSYPIFGNLFKFLPYIGEYGNLPLYEQMKLLNKQYGKIVKLEGVFGRRPSVFLYDPEQCEKMYRVEGAWPLRIAIETMCTYRERNSKVYKGKLGLVGRAKVKPGTSLGKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HFG4</accession>
    <name>A0A8J2HFG4_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Similar to ZNF277: Zinc finger protein 277 (Homo sapiens)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HICCMSTLAB_LOCUS9128</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the ZNF277 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5099576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HFG4"/>
    <dbReference type="OrthoDB" id="278606at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041661">
        <property type="entry name" value="ZN622/Rei1/Reh1_Znf-C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040048">
        <property type="entry name" value="ZNF277"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13267">
        <property type="entry name" value="ZINC FINGER PROTEIN 277"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13267:SF3">
        <property type="entry name" value="ZINC FINGER PROTEIN 277"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12756">
        <property type="entry name" value="zf-C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="209"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="6">
        <location>
            <begin position="505"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00034119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG5099576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="634" mass="75054" checksum="AABB5FE69B4C9486" modified="2022-05-25" version="1" fragment="single">MSSTRNSYQSKAPSANELAEKYKVYYKSQFVGIDNDPGESECLFCDLSFILPTNEKDYLFHLFEKHRLVIGDVEKIASLRSYVHYWKARCKNESLINFCTTMLMDCTPDGKPSKGEVYYLLSDCIAEDKTLRDEIQRAKLEWVINQQTYERTDTNFKRGCMICKQEFSGLRITYLTHLKEKHNIQFGKYHNLVFVDKLLDKIQYNFDNFICIYCEKVFKDRNVLKEHMRKKLHKRINPRNKSYDEFYITNYVKPRDPLCHKEDEFDDEYDAIVFSDNEDEENLWSDWTAENNPITCLFCSVKIPELPNILDHMKDEHDFDFNKLTENLNFYEKIKLVNYFRKQVHEKKCVFCDQQSDDCLQHMKNEDHFKIPPARIWNLEKYYSPMCKEDPFLYHLDTGSDDECDESNIDKLSDDINNSFEKYKIKLEGSMSALVFQKSKYCVLKLHQNLPHKFLAPEINEMYQIAWYDYLEKIRRTIGGKTWIPDTQVIVHLNNEYIGNHSDLFDFVDQNFIINLPIDTEFYENLINENLGYENNFIDETTIVAENYLILHDRRGVLSLANDGKNHNGPQFVVSLNPNPWMDNYYVAFGQLIDGANTLKIIEQLNTFYESPLQKIVITECGKFSIDQNNNQVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HFK1</accession>
    <name>A0A8J2HFK1_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Amino acid transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HICCMSTLAB_LOCUS7173</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Membrane</location>
            <topology evidence="1 7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5093847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HFK1"/>
    <dbReference type="OrthoDB" id="5877963at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015501">
        <property type="term" value="F:glutamate:sodium symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005313">
        <property type="term" value="F:L-glutamate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015175">
        <property type="term" value="F:neutral L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3860.10">
        <property type="entry name" value="Sodium:dicarboxylate symporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050746">
        <property type="entry name" value="DAACS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001991">
        <property type="entry name" value="Na-dicarboxylate_symporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036458">
        <property type="entry name" value="Na:dicarbo_symporter_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11958:SF99">
        <property type="entry name" value="SODIUM-DEPENDENT EXCITATORY AMINO ACID TRANSPORTER GLT-6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11958">
        <property type="entry name" value="SODIUM/DICARBOXYLATE SYMPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00375">
        <property type="entry name" value="SDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00173">
        <property type="entry name" value="EDTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118215">
        <property type="entry name" value="Proton glutamate symport protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0769">Symport</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="51"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="94"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="130"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="236"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="274"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="308"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="346"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="387"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="18"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="28"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAG5093847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="531" mass="57065" checksum="31F67DDAA49B0BFB" modified="2022-05-25" version="1">MSLKQRITGAVAVLRGAPIPEPQQNVEAGEKEKNPDSDEPKSNKCQALKKWFSMNLLLVLTVIGVFSGLGLGFLGRLADLSPDTIMLVNYPGEILMRLLKMFILPLIISSLITGMAHMDPRSSGRMGYRALTYYTVTTLLAAIVGIAVVLAIHPGDPLIKNSVSTTSAFSDASKVSTLDALLDIGRNMVPENLIQASFQQAQTTYVKKPVIVVFGRTNNSETVIERTLIYKDGTNVLGMIVFCITFGVLVGQLGPKAQIMVDFFGALNEIIMKIVHLVIIWYSPFGIMCLIAGKVMSIDNIVSTAQMLGFYMITVAIGLSIHGLITLPLIFWVITRRNPATYFKGMIQAWITAAATASSAAALPITFRCLEENNKIDARVTRFVVSVGATVNMDGTALYEAIAAIFIAQLNGISLSFGDIITVSFTATLASVGAASIPSSALVTMLLVLGALGLPTNDVSLLFAVDWLLDRLRTSVNVLGDGFGAGIVYHLSKDELDLVDQAKKIDTIELGDPEAENSGVNQVAEVSETKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HG19</accession>
    <name>A0A8J2HG19_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Similar to BCL2L1: Bcl-2-like protein 1 (Homo sapiens)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HICCMSTLAB_LOCUS9086</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Bcl-2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5099482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HG19"/>
    <dbReference type="OrthoDB" id="6021377at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051400">
        <property type="term" value="F:BH domain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097192">
        <property type="term" value="P:extrinsic apoptotic signaling pathway in absence of ligand"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008630">
        <property type="term" value="P:intrinsic apoptotic signaling pathway in response to DNA damage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042981">
        <property type="term" value="P:regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001836">
        <property type="term" value="P:release of cytochrome c from mitochondria"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06845">
        <property type="entry name" value="Bcl-2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.437.10">
        <property type="entry name" value="Blc2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036834">
        <property type="entry name" value="Bcl-2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046371">
        <property type="entry name" value="Bcl-2_BH1-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026298">
        <property type="entry name" value="Bcl-2_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002475">
        <property type="entry name" value="Bcl2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11256">
        <property type="entry name" value="BCL-2 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00452">
        <property type="entry name" value="Bcl-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00337">
        <property type="entry name" value="BCL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56854">
        <property type="entry name" value="Bcl-2 inhibitors of programmed cell death"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50062">
        <property type="entry name" value="BCL2_FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bcl-2 Bcl-2 homology region 1-3" evidence="4">
        <location>
            <begin position="123"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="40"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAG5099482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="246" mass="27384" checksum="BE7D0FBE2FF860A1" modified="2022-05-25" version="1">MAGDSTTNNEIGEGVEQGASVRGERHSRVGGILECDPPGNRNSLSMSDQANENTDDDEDGVCRYGIRLQNFFPHLAPPSSRYGICDDNVELTAEILAHDVIRYLLKEDMYLISRDSISRSMRHNVYQMLNKHSILFTSMVNRLNVVPDTAYEAFTGVADELFLHGEITWAKIVCLYAFMGRLALWARDGRMHALKQKLPLYVSRYIGEAIAHFIKVAEEVSGAVWRSLLMTGATLSLVATILTVTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HG61</accession>
    <name>A0A8J2HG61_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Cytochrome c oxidase assembly factor 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HICCMSTLAB_LOCUS8858</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Required for assembly of cytochrome c oxidase (complex IV).</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of 250-400 kDa complexes called cytochrome oxidase assembly intermediates or COA complexes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the COA3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5097749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HG61"/>
    <dbReference type="OrthoDB" id="10018333at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041752">
        <property type="entry name" value="Coa3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018628">
        <property type="entry name" value="Coa3_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15642:SF3">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY FACTOR 3 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15642">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY FACTOR 3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09813">
        <property type="entry name" value="Coa3_cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="48"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome c oxidase assembly factor 3 mitochondrial coiled-coil" evidence="8">
        <location>
            <begin position="32"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU367056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF09813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAG5097749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="88" mass="10413" checksum="9E206C8F43A4DF35" modified="2022-05-25" version="1">MDKEEMPPVDFDKEKKLSSLQRHLAKRIHELNLKRAVRMIEIRKTNRWMATGLFAGVFGIYFYTIHAVKQEKFLDDFELPETVSTEQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HH64</accession>
    <name>A0A8J2HH64_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Similar to sec22b: Vesicle-trafficking protein SEC22b (Xenopus tropicalis)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HICCMSTLAB_LOCUS7539</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="7">SNARE involved in targeting and fusion of ER-derived transport vesicles with the Golgi complex as well as Golgi-derived retrograde transport vesicles with the ER.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Golgi apparatus</location>
            <location evidence="8">cis-Golgi network membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Melanosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the synaptobrevin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5095098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HH64"/>
    <dbReference type="OrthoDB" id="1719357at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14824">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.50">
        <property type="entry name" value="Longin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010908">
        <property type="entry name" value="Longin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044565">
        <property type="entry name" value="Sec22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45837">
        <property type="entry name" value="VESICLE-TRAFFICKING PROTEIN SEC22B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13774">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01270">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50859">
        <property type="entry name" value="LONGIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Longin" evidence="9">
        <location>
            <begin position="6"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAG5095098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="112" mass="12828" checksum="FCDC6B57C34FC1F4" modified="2022-05-25" version="1">MVLLTMIARIADGLPLAATMQEDEQSGKSILEYQNQAKMLFRKLGPQSPARCTIETGPYLFHYLIENDVCYLVLCERNWSKRLAYSYLEDIAQEFYAQKLKSLSPMEGQGEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HHB4</accession>
    <name>A0A8J2HHB4_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Similar to Tm2: Tropomyosin-2 (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HICCMSTLAB_LOCUS9618</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the tropomyosin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5100545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HHB4"/>
    <dbReference type="OrthoDB" id="128924at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000533">
        <property type="entry name" value="Tropomyosin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19269">
        <property type="entry name" value="TROPOMYOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00261">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00194">
        <property type="entry name" value="TROPOMYOSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57997">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="113"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG5100545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="284" mass="32501" checksum="DC5EAD1AA47D1BBA" modified="2022-05-25" version="1">MEAIKKKIAALKQEMDAANEKVEANETKAKQEDFRADLLFDEARSLAQKLITIERDYEVAKVNLETTTAALETCEKAYTKAEQDRTVLTKRVQEIEVSLTKKEELRLLAAAKLVRATELADDAQRMCNVLEDRNRIVQEHMAKLTEELKDARLIAEDADAKSEEIAEKLSLVEEELENAEERVKNSEAKIIEREDELFIVQNIFKSLEVSEKKANQRVADSKIQVKELKAALKAAEKRAIQAEKTVRALQKEVDRKEDELREEKEKCKAIIDDMDLTFAEMTGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HHE7</accession>
    <name>A0A8J2HHE7_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Isoforms J/P/Q/S/Z (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS8869</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5097771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HHE7"/>
    <dbReference type="OrthoDB" id="10004641at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="21"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5097771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="177" mass="20159" checksum="679FC99A15F353F8" modified="2022-05-25" version="1">MFYYYTQAFIYNPQFQSSNVFRCHFCGRSFTWIASLRLHQKMACGKPPNFYCSLCTYKSNFKGNLKRHMFNVHKIVLPPAISYRQAPAPRVSSLRADVLLGIEPQEAPQNGLWQAQQHSLFLPLLPLQIQSTRQFLQASPLCAQHQKSILCPAPVQGLTLPVIRARYATDSIVSEAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HHX9</accession>
    <name>A0A8J2HHX9_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Similar to ATAD2: ATPase family AAA domain-containing protein 2 (Homo sapiens)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HICCMSTLAB_LOCUS9786</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5100713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5421at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006334">
        <property type="term" value="P:nucleosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006337">
        <property type="term" value="P:nucleosome disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045815">
        <property type="term" value="P:transcription initiation-coupled chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05528">
        <property type="entry name" value="Bromo_AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000061">
        <property type="entry name" value="ATPase family, AAA domain-containing 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045199">
        <property type="entry name" value="ATAD2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23069">
        <property type="entry name" value="AAA DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23069:SF0">
        <property type="entry name" value="TAT-BINDING HOMOLOG 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00503">
        <property type="entry name" value="BROMODOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00297">
        <property type="entry name" value="BROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 5" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bromo" evidence="7">
        <location>
            <begin position="923"/>
            <end position="993"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="89"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="163"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="330"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="92"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="163"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="196"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="240"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="277"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG5100713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="1298" mass="148759" checksum="A2342146D7407FC9" modified="2022-05-25" version="1">MSDDDIAMDSIDTDEDIFSSHNSTLRNNVRRSKNARTLRSHSSNNSLITRNNLSVRRSTRNRMQTYDNLNTSWILGTQTLKGYPMFQQHVSSSDKEMAEESPSRPRDIRERMPLKSRENHHPTKNTRHIRSRVDLTNRELRTRVDRDREREIRKNTDQDIDEIDLRQLKDRPDRKSNDKDVKYKSGNRNKIIVSVDNEKELEPQKSDGPIRSREGPITRLCGMLEKDETNKVSSNSVNEDSSHESDKQVENGNSDNDIGFEDMYTRIKRTRRASQRQLERNKKLSEESDLSESSDSPGPRKYSLRKKKPTVDRFQANVEPVRRSIRALRTVLSNSMRRRKHRSKSSSSNDSSDSEPQRYDKKKCKKVRQNALPQGCPTDKKADISPITLDTNIRFSDVGGLESHVHCLKEMVVFPMMYSDVFDRFHITPPKGVLFYGPPGTGKTLIARALANEFSQQGNRKVTFFMRKGADCLSKWVGESERQLRLLFEQAQQMKPSIIFFDEIDGLAPVRSTKQDQIHASIVSTLLALMDGLSDRGEVVVIGATNRIDAIDPALRRPGRFDRELFFPLPAMKERLEILKIHVGQWKNPPSDGLLELLAEMTTGYCGSDLRALCTEAVLQGLRRTYPQIYLTSNRLLLDPQRVEIKQQDFIEAASILVPSTHRIAPSISRKLQSFLIPLLGNALEDLINVVKVIFPQGINSTLAKIKLAKGLHHPRMLVTCDSMSYGQSPKLTQALLYRMEHVFVQPLDVSTLFAESAKTPEEICVQVFNEASRKIPSIIYIHSIDQWWQLLPETVKAVFMCRITTLDPSLPILILATSDVPYSDLVPQIKNLFSRSRGEVYTIKNPTVEQRSEFFKPIFTEKCVQPPILIDNKVQKLEELPLAPEPEPKKLTEGEKKILYEKEEVSLRELRIFLREICAKLARNRQFFMFTKPVDIEEVPDYNAIIKQPMDLETMMTKIDMHCYLCARDFLDDIDLICKNALEYNPDRDPADKLIRHRACSLRDHAYALIKAELDSDFEDKCREISKSRMVPKIADDESVKNESFIINEKNVKKEMLSPSGSVVINGRKVSSRKRKIPAWARGYVKKVTKKKKIMFDDNPAESNEKPCSVSSNNGIRNVDLEKFQEFVANRVLNGDTTLYDNTESENDSLNETIREVKNNANCEVTIEQSSVDVEVSPVNEQVSIENGEPNVVSSNEKLGNASLTVDCDHEQSKLKEMDVVMIDKAKLESMWKYTVDVTSKLSIEELCDIYVQFSRCVSTYDHTYDRKSLPKDLLRNLQQFKNISNKTADFTMDVDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HIE2</accession>
    <name>A0A8J2HIE2_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Isoform G (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HICCMSTLAB_LOCUS8898</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5097829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HIE2"/>
    <dbReference type="OrthoDB" id="10004641at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24409:SF295">
        <property type="entry name" value="AZ2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24409">
        <property type="entry name" value="ZINC FINGER PROTEIN 142"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="57"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="86"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="265"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="435"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="148"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG5097829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="587" mass="66827" checksum="15666FFB54467A5E" modified="2022-05-25" version="1">MLATIENNGIFLSDPCTDFQPQSMLLGKQGACGYSVLPLMKNLATMWLAKQRTQFSYRCDRCGKGYQHRATLVRHTRHECGKDPKFKCPYCVHRTKQRGNLYQHIRTNHPGKNVFTKNSKIVRAVTDERVVIFRTVGELPLAGVPASGELLDAPGQHEDDAKLPTIDDPPGVPRQETRVLLLPEVRQGLPVAQEHEEPPEDRVREGAHRVLSVLPPQDQIQAQPPEAHPQNSFLIITKVSPLKFFLQREKEEILFCTGNNYWGASRCEYCGREFIWESSLRLHKKMACGKPPNFFCSLCTYKSNFKGNLKRHMFNVHKIVLPPAISYRQAPAPRVSSLRADVLLGIEPQEAPQNGLQHAHPRHSLFLPLLPLQIQNPGQLLQAPPLCAQHQLAVFLTKDFISIWYIPETVLARPKKASKAPRASKRKIKKSNYEFTCSACKKTFPTSANLRDHIRRYCGVDKNIICRYCSHRSKRLWDMRVHLERVHHISKDHFTLHRDERGSSGKASKTEASADLQARLDALIIRRWSAVHFVITQATEGGTSSRILKEFIPPLDVDFSQRCRGEGTPKLETKNSYSGRWTQLFKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HIK1</accession>
    <name>A0A8J2HIK1_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Odorant receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HICCMSTLAB_LOCUS9997</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Cell membrane</location>
            <topology evidence="1 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the insect chemoreceptor superfamily. Heteromeric odorant receptor channel (TC 1.A.69) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5100924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HIK1"/>
    <dbReference type="OrthoDB" id="6617147at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005549">
        <property type="term" value="F:odorant binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004984">
        <property type="term" value="F:olfactory receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004117">
        <property type="entry name" value="7tm6_olfct_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21137">
        <property type="entry name" value="ODORANT RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21137:SF35">
        <property type="entry name" value="ODORANT RECEPTOR 19A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02949">
        <property type="entry name" value="7tm_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 10" id="KW-0552">Olfaction</keyword>
    <keyword evidence="8 10 11" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="9 10" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="28"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="53"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="87"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="146"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="211"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="316"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU351113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAG5100924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="414" mass="47799" checksum="B11943FF6532CFE2" modified="2022-05-25" version="1">MSLSKSETEKILTPKNNNRTDVEIYVKHTRWLFFILGLWPFMFYTLTRHKLCLAVVIQIICYITLFFAIIPSFYHMFWYDKSVNVKIALFGPTGVSVACVFKYFAITYHLKNIKECLKQIQKDWEMTTNKNDWEIMVNYAKKGNNVTFFCITVMYGGGVSHQSVAPFLPGSPTTLLRNSSDRPLLYPTSMFDPYFNTQKSPIYETFYLSHILMGVVVCTMMISTCNLGAILVTHICGQIEIIIRRLQNLEKYQSNGENFYHSLSAIIQRHNKVIKLSLYTEQILRQVCLVEVVAATLFICMDEYYCLLAWKNNNQIGLTIYSILLVAFIFNIYIFCHIGELLKQQFGKIGDSIYAINWYNFSQKNSSNLIMMIAISQNPQKITAGGLFELSFKGFSSVLKTSVAYLNILRMMEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HL46</accession>
    <name>A0A8J2HL46_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS11083</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5102574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HL46"/>
    <dbReference type="OrthoDB" id="7692610at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5102574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="371" mass="42107" checksum="AFD2BA4E48F76D75" modified="2022-05-25" version="1">MPPTKQKMQEFTYALIWFISTRERFVVETSKLPKTRRKKGNVVKIIWEDPSTLISQRFDVKILELGSDKNQLENIVLDEDGNICDDSTKAFFRSVLDKKRSLQEELKEGNKASKIQKTSLEHIISKKKPLFELNGCSSKNQKTSTPSMKIDKPVIKISPQLNNSEQSNLTEIDLLQSNQSSVNNSKNNQSSPIETDEPYSINILPSTSGVQKFVKNQEQVNNESKKVTKDIEVLVSDTEDMGALHTFLPVTASEENKKFLKQIYAGLSAAYQYQNTKMSKMIKSFKVNGENKKEISPNSHIYFPIKLIESIEQSAVTETGMIDWKKILKLALMEIYGNSIANYSAIGRNKNSRPPIDHDIYEGIFRSVATL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HLW9</accession>
    <name>A0A8J2HLW9_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Similar to Thsd4: Thrombospondin type-1 domain-containing protein 4 (Mus musculus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HICCMSTLAB_LOCUS10069</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5100996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HLW9"/>
    <dbReference type="OrthoDB" id="5781878at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030198">
        <property type="term" value="P:extracellular matrix organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.100.10:FF:000005">
        <property type="entry name" value="ADAM metallopeptidase with thrombospondin type 1 motif 9"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.830">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.100.10">
        <property type="entry name" value="Thrombospondin type-1 (TSP1) repeat"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013273">
        <property type="entry name" value="ADAMTS/ADAMTS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050439">
        <property type="entry name" value="ADAMTS_ADAMTS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045371">
        <property type="entry name" value="ADAMTS_CR_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010909">
        <property type="entry name" value="PLAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000884">
        <property type="entry name" value="TSP1_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036383">
        <property type="entry name" value="TSP1_rpt_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13723">
        <property type="entry name" value="ADAMTS A DISINTEGRIN AND METALLOPROTEASE WITH THROMBOSPONDIN MOTIFS PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13723:SF316">
        <property type="entry name" value="LONELY HEART, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19236">
        <property type="entry name" value="ADAMTS_CR_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08686">
        <property type="entry name" value="PLAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19030">
        <property type="entry name" value="TSP1_ADAMTS"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00090">
        <property type="entry name" value="TSP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01857">
        <property type="entry name" value="ADAMTSFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00209">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82895">
        <property type="entry name" value="TSP-1 type 1 repeat"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50092">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="57"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="ADAMTS/ADAMTS-like cysteine-rich" evidence="9">
        <location>
            <begin position="197"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="PLAC" evidence="8">
        <location>
            <begin position="817"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="117"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="121"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="132"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR613273-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF19236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAG5100996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="847" mass="94542" checksum="7EB6C2411941CBA9" modified="2022-05-25" version="1">MDINVRVLYEKKKNRMEIKKRYLLVARTSGAKTTLRCAKSNSPYQFKERKYSGVNYFAHRCILLLIILSTASLVHTYVPEKYPIEVYHMLQERTQYGFGKDNRVRGSWGTWSSWSECSRSCGTGVQSQARQCVLRNSVRKRSIISQVNSTSLKPVCIGTYKRYHICNTQDCPEFSEDFRAEQCAKFNDRVYKGEKHAWVPFLNAPNPCALNCRAVGQRFYATLEPEVIDGTPCDGPNLRGKSMGLAVDRTTEQWVCVAGQCRSVGCDGVVGSGAVRDTCGVCGGQGRGCKLFEGIFMEPILPKGHQPRGDRNRMESITATGPLNESLNLEIWYHEMNPGVLYKYMLPAPENFNDNAIIAPPLYANEIPESYPRVEVSLRRPEVNLSRNQVREETQKVKKDEVKFSPTTVMAGDAPNINVNVSQSEIKPKKKKRKFAWKVMGLSSCSKTCGGGVQSTIIKCLREDKDNVVPDRRCRKFEKPPAPPPLQCNDRPCPPRWRADAWSKCSTSCGTGVKTRRLECIQDLNSKITMRVAAGACSQPPDLSTVGSCEGPPCPNNQIPQVRQMETLDVSAGIPGRWEVGPWGPCSSKCGKGSMNRTVVCITSGEPCPVSARPIDERACEASCETHPQHESMWLYTEWTSKCPAECEREMETRRIACGGANELFCDSTKRPATERRCSFNETRSCGARWFTGPWSSCSVACGEGIARREVICIGNSSGESKILTESNCSSTRPPAEQICRMPQCPPEWFTSDWSMCTVSCGGGTQERVVRCLDQGLSSSCDTITKPEDRRPCNVEPCKDVSLVHKTPKKVHLANECVDKYPNCMLVVKAGLCRYKYYKHSCCGCRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HMH1</accession>
    <name>A0A8J2HMH1_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Similar to Wdr33: pre-mRNA 3' end processing protein WDR33 (Mus musculus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HICCMSTLAB_LOCUS11961</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5104356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HMH1"/>
    <dbReference type="OrthoDB" id="16717at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005847">
        <property type="term" value="C:mRNA cleavage and polyadenylation specificity factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031124">
        <property type="term" value="P:mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000237">
        <property type="entry name" value="Flowering time control protein FY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000077">
        <property type="entry name" value="WD repeat domain 33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045245">
        <property type="entry name" value="Pfs2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22836:SF0">
        <property type="entry name" value="PRE-MRNA 3' END PROCESSING PROTEIN WDR33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22836">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="166"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="208"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="299"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="329"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="373"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="416"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="460"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="841"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1002"/>
            <end position="1135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="22"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="871"/>
            <end position="886"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="903"/>
            <end position="912"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1002"/>
            <end position="1013"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="1014"/>
            <end position="1025"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1026"/>
            <end position="1037"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1084"/>
            <end position="1093"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="1094"/>
            <end position="1105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1106"/>
            <end position="1115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1123"/>
            <end position="1135"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAG5104356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="1135" mass="126526" checksum="1F57ECCB90358D18" modified="2022-05-25" version="1" fragment="single">MSTNVQFANPPPPTGISLPNMSVPPPTAPNLSAPPPNLTTINTAPGGFQSQQQQQQQQRFLNHRDNTRGFFKPFRPYHAPKIVSGSQDALQDEFDGKRLRKSVMRKTVDYNSAIIKTLENRIWQRDFRDRRPLQPDVMYYPDLLPPPSYVDNPINAVTTRFVKTATNKMRCPIFCMAWTPEGRRLVTGASSGEFTLWNGLTFNFETILQAHDSPVRTMVWSHNESWMVTGDHSGYVKYWQSNMNNVKMFQAHKEAIRGLRYIIIHHSSPFVSRDTMLFIRTTIVFVYCWSAPSQMDFLFSPTDHKLATCSDDGSVRIWDFLRCYEERTLKGHGSDVKCVHWHPQKSLVVSGSKDNQQPIKLWDPRTGQGLVTLHAHKSTVMDIKWNDNGNWLVTASRDHLLKLFDLRNLGQEVQTFRGHKKEASSVAWHPSHEGLFCSGGSDGAILFWHVGADKEVGAIEQAHDSIVWTLAWHPLGHILCSGSNDHTSKFWTRNRPGDLMRDKYNLNTLPAGAAGIDDHEIADEAAVIPGMGPEDKINEFDLEQSMEEDTSQGIPGLDLDHAAEESKKLAASKKVPYSKPIPRNFQAQWNEMEAEDPEQVEALNAIVNQLIETTPGAVPLNEVAPNAIILYGKIIPVEPGSKLSEAIVKGNDAINKLITAGEIEELRDVAINLPEEPEIEEDYLQDEGEIDYTKVPNVDLPPPLPSSKFAQNPELLKALNYGGKRKFDQLIAWTEANPTERGNKMHQPVFGAGGMSDDSLSNNDSDLRIMPGMKNPQDSYFANQDEDLRRINSVDNRGGMGRDEDMRMNVASASGPGRPPGMMMNEFDMRNSFDMRNSYGDRDFRHLGPPPIIGGFKKSSMDANDNFGSGDMDRDGRQRSWDDDKGMNSNDSGRSNFDKRDMSSNMQNNSMQIPMGNMPSGNMGSNHHNMQNISPNMPPSMMSMMPPHHQQHHQMNHLPNIQNKNNSNMMGGNDNSGPMPPHMMHMSNFGPNGPPPMPPNFGPNFRPPNGNYGPNPPYRPNPMAPFAPSQNMPFNNNFPPPNFRGPNPGNNQMSNFDRPPGFGPNFRMSGNQSGPHGSGGGNFNSGYGKNYNNSGGGGGNMGSSGSGNNSGNKNGPYRGQRYKNNNNKNNNNNNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HMH3</accession>
    <name>A0A8J2HMH3_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Tubulin-specific chaperone E</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Tubulin-folding cofactor E</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HICCMSTLAB_LOCUS10370</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TBCE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5101297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HMH3"/>
    <dbReference type="OrthoDB" id="5273213at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd17044">
        <property type="entry name" value="Ubl_TBCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.190">
        <property type="entry name" value="CAP Gly-rich-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036859">
        <property type="entry name" value="CAP-Gly_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000938">
        <property type="entry name" value="CAP-Gly_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044079">
        <property type="entry name" value="Ubl_TBCE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15454:SF73">
        <property type="entry name" value="DYNEIN AXONEMAL LIGHT CHAIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15454">
        <property type="entry name" value="NISCHARIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01302">
        <property type="entry name" value="CAP_GLY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14580">
        <property type="entry name" value="LRR_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01052">
        <property type="entry name" value="CAP_GLY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74924">
        <property type="entry name" value="Cap-Gly domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00845">
        <property type="entry name" value="CAP_GLY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50245">
        <property type="entry name" value="CAP_GLY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="CAP-Gly" evidence="9">
        <location>
            <begin position="31"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAG5101297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="532" mass="60961" checksum="ADF36183AC2D6185" modified="2022-05-25" version="1">MVESVGTVSDCHKIGDRIDCDGHPGTVCYIGPVIDTNGLWLGIDWDDPARGKHNGTYHDVEYFKTILPTSGSFVRPGKVKTGISCLDAIRQRYGLVDDELAGVDRDKLFILKREIHAPFLEMVGFSKVNKKQSAFDQLKVVWLRDQLVSSAGVPGELLELCPNVRELDISKNLINSWRIVADICIQLKKLERLDVSENLLPTKIDVDLNAFANVNQLVMTRMNYDWSDIEWCSSLFPALRVLYVPFNSARVLREPLENSSLTQLVDLSLEGNNLSDWDEVLKLGNLLSLENLNLNSNKIERVKFFCDDGEEKTKSFPKLRQLHLSKNCITEWRSISELEKLNNLEDLKLRDNPVFDNEKLTTTRDLIIARISKLKLLNGEEIIREERNGAEYVYLKTFDEEWKNIADSDECQKKEFIENHPRYLSLIKKCGITEFPSSTKFSTEMKSDVITVEFVSSNVESKVQNVKRKIMKDMNVQKVMGLVQRIFKISGKIPTLLLIPSNRPNDEIPLDKFLQELSYYSIQDGDKIIVHW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HMN7</accession>
    <name>A0A8J2HMN7_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Period circadian protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HICCMSTLAB_LOCUS11519</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5103457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HMN7"/>
    <dbReference type="OrthoDB" id="7788983at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001222">
        <property type="term" value="F:transcription corepressor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032922">
        <property type="term" value="P:circadian regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043153">
        <property type="term" value="P:entrainment of circadian clock by photoperiod"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022728">
        <property type="entry name" value="Period_circadian-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050760">
        <property type="entry name" value="Period_circadian_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11269">
        <property type="entry name" value="PERIOD CIRCADIAN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11269:SF16">
        <property type="entry name" value="PERIOD CIRCADIAN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12114">
        <property type="entry name" value="Period_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0090">Biological rhythms</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Period circadian-like C-terminal" evidence="8">
        <location>
            <begin position="669"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="55"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="129"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="426"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="738"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="14"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="142"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="207"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="748"/>
            <end position="758"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00040849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAG5103457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="785" mass="89075" checksum="37AB54ED92F91D1A" modified="2022-05-25" version="1">MVGEISSHHDYGGSKSSSETPPSYNQLNYNEKIERFFKSKPIVKTAYGSDEETFHFNAQSSDTNARKNDSGGSGTGENLSHESINLTSGKDDILNNNSSLIPTDNFRPMALTKMLLERHDHDMEKLMVQKHKERQSNIKTGNISNNCKNNNNDCYSNDLNVNNNNNNNNNNNNNNNNNNNSNNNSDDNNNDNNNNNEMTEEPSSGSENEKIQDKSRYGKRNSSLIIEAEYIKTFKYSKKAKICPKNGKSLSINKTRFEKSPIDESMDQDDSMFKSIDPENSQPLPLLEALLTKHNKNIEKLMIQEHKDQLSNFKADKSNINLRRKREISEESELNSSLNKARHWNCSVGHSCKNDLFKMPKYNKKNKNSVKSNNTGPYMKTKIDKLIINDPRSNLGMWPLIHHNPLRCSGLTQILPIYYLPISQSESDSQNTESQSTQQLQQQQQLHQHQQEQYQQSSFVSYTPSFSGIYHSTIIGGPAFIPMIYPSLMTQLPNKSNHQLRATFSSENLSMEQNRPASQATSVKAEPGSIMAMSESSKKLFSPSAHYSPCISIETRSGENDSSIEDSSDSSFYGSFLNTSTNSSSNREQPTAHAARFLEYITPLGKENKKSLRSHVIVGRGEAEINKHINALKYAEGETINRRFAMVNNLKNNIEQYNTEAATPLLPQKSLPWYHGVKMTPEISYNYQMTPKVLSEVLKTDLQVLKTLKQPLLVNEQLDQLYRDLELGGFGTKLLLDDSNSSNDSERTNQSSKFNVSSQHKRIRREMKYNKYAMIYEEDAPFPSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HMW8</accession>
    <name>A0A8J2HMW8_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Bestrophin homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HICCMSTLAB_LOCUS11939</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Forms chloride channels.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the anion channel-forming bestrophin (TC 1.A.46) family. Calcium-sensitive chloride channel subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5104312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HMW8"/>
    <dbReference type="OrthoDB" id="201595at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034707">
        <property type="term" value="C:chloride channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005254">
        <property type="term" value="F:chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000615">
        <property type="entry name" value="Bestrophin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021134">
        <property type="entry name" value="Bestrophin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10736">
        <property type="entry name" value="BESTROPHIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10736:SF65">
        <property type="entry name" value="BESTROPHIN 1, ISOFORM C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01062">
        <property type="entry name" value="Bestrophin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0868">Chloride</keyword>
    <keyword evidence="6" id="KW-0869">Chloride channel</keyword>
    <keyword evidence="6" id="KW-0407">Ion channel</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="32"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="76"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="238"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="279"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="428"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="465"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="565"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="485"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="616"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="634"/>
            <end position="643"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00034769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG5104312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="702" mass="78914" checksum="239681932AAFC0C3" modified="2022-05-25" version="1">MTVTYTAEVATCRGLGCFLKLLLRWRASIYKLVYIDLLLFLTIYYTLSIIYRFALNEEAKRKFESVVAYCNEYSDLIPLSFVLGFYVSIVMTRWWNQYMAIPWPDSIAVFVSATIHGNDERGRLMRRTIVRYVCVCLTLVLSNISPRVKKRFPTLDHFVDAGLLLENELVIFQNLNMKFPKPSKHWLPIVWASSIVTRARKEGRIRDDFAVKTLIDELNKFRGNCGRLIHYDTISVPLVYTQVVTIAVYSYFLTTVMGRQWVETTKSEQKLSNISNIDLYFPFFTTLQFFFYMGWLKVAETLINPFGEDDDDFEVNWIVDRNLQVSYLIVDEMHHDHPELIRDQYWDEVFPIELPYTAAAEPFREEHPVPSTAGIQLSAAQQELQPSSVRIDEMNPPSDLPYNKFRSDVADDAISGIHFMSDSKMSRSASRISNRDRYNGGGSTASNIGESLPRVNSVTSVLKRLFSKEDRPDGNAGKTPGRIPNSGSSASLQNRMSGVPAAGGSTRMGFGAIEEVDEQMTIQSIRAGEPRPHVQSIFASGAPPPSAPVDVPSYKNRHHDLLSVSAPVGGARPHHVRPQRSVNNSMGLPIGGSPASDTPIDNPEGPIEEHIQDNLSVRSSSSSQGSHFSNSDDDFNRLKSERIKQRRDKAMRKLVKSIGSSRQGISGNIRSSLELDGETLLLTELAEASKFALTSSNKPENV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HN04</accession>
    <name>A0A8J2HN04_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similar to mats: MOB kinase activator-like 1 (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS12324</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5106567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HN04"/>
    <dbReference type="OrthoDB" id="8170117at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.30:FF:000001">
        <property type="entry name" value="MOB kinase activator 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.30">
        <property type="entry name" value="MOB kinase activator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005301">
        <property type="entry name" value="MOB_kinase_act_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036703">
        <property type="entry name" value="MOB_kinase_act_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22599">
        <property type="entry name" value="MPS ONE BINDER KINASE ACTIVATOR-LIKE MOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03637">
        <property type="entry name" value="Mob1_phocein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01388">
        <property type="entry name" value="Mob1_phocein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101152">
        <property type="entry name" value="Mob1/phocein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="1">
        <location>
            <position position="79"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="84"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="161"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="166"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR605301-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5106567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="217" mass="25054" checksum="0A6F1AE811A1501D" modified="2022-05-25" version="1">MSFLFGSRSSKTFKPKKNIPEGTHQYDLMKHAAATLGSGNLRLAVMLPEGEDLNEWVAVNTVDFFNQINMLYGTITEFCTEESCPIMSAGPKYEYHWADGHTVKKPIKCSAPKYIDYLMTWVQDQLDDETLFPSKIGVPFPKNFLSIAKTILKRLFRVYAHIYHQHFSEVVQLGEEAHLNTSFKHFIFFVQEFNLIERRELAPLQELIEKLTAKDAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HN06</accession>
    <name>A0A8J2HN06_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS13724</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5109088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HN06"/>
    <dbReference type="OrthoDB" id="565904at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012674">
        <property type="entry name" value="Calycin"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50814">
        <property type="entry name" value="Lipocalins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035204395" evidence="1">
        <location>
            <begin position="21"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5109088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="192" mass="22169" checksum="A3D6B61CE9E3B0F2" modified="2022-05-25" version="1">MKILSTFIIFCSIATSFLYAQDSSDCPVPCGGGEVDLYRYAGKWRDYQQSRNNIFHFGIFPTSYWYKPVNGTSTAVVTSYSTIKKEYDTTILADAFNNGHNLGMNFELPVLGNLYREYYIRTDYDNYSLAWNCVKENNTRVLYANVFLRGDEPKVDIEEIKRRVFGEMGMEVPLMDQVDRRGCPPFSERSLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HN75</accession>
    <name>A0A8J2HN75_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS11416</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5103251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HN75"/>
    <dbReference type="OrthoDB" id="5953030at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5103251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="100" mass="11064" checksum="1FF3C53822B9D9D5" modified="2022-05-25" version="1">MVKETKEHGLKLNLNKTVAIILGSTGKLRLLNIASLPPIVIDGIALPYVTTIKCLGLTVSNNLSWKNHVSNTGKKVNSALYSLKKMYFDVPKDLQTKRIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HNV9</accession>
    <name>A0A8J2HNV9_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Large ribosomal subunit protein uL29m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HICCMSTLAB_LOCUS11342</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the universal ribosomal protein uL29 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5103103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HNV9"/>
    <dbReference type="OrthoDB" id="270763at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.330.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038340">
        <property type="entry name" value="MRP-L47_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010729">
        <property type="entry name" value="Ribosomal_uL29_mit"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21183:SF18">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL29M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21183">
        <property type="entry name" value="RIBOSOMAL PROTEIN L47, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06984">
        <property type="entry name" value="MRP-L47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAG5103103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="414" mass="48774" checksum="1FC43A426FC7EF96" modified="2022-05-25" version="1">MTRDAQNVADWARENGLELNLHKTKVMLLGSKSKVASLQRAGLPQIVIDGVALPYTESTKCLGLHLTSDLSWNLHISKTVSKINSALYSLKLRKNIYTPNIKKLLVSATILPLIDYCSIVLSNSTYDNDLKLQRSLNSAIRFIFNLKRDEHITPYRRELGWLTVKSRRIYYLSCYFYKLLDIGKPCYLRELFIEDPNLRRSERLAAKRNNISFVMPFFSTTQYESQFIVTAIRLWEELPATIIEYVLLKEKNMLLTMEHAYNEAYEYFPNPERRDKVEESMSNLEEVVRERNIAYHELETGEHGERPSRYMSNQLGLRYRYKYCEHIIPAFMNKSWREKHITTYGGYAVTKFRRLYREKLFLEKRREINRQTNQAKVVLKRFPNVDMEALQAAYPKANVKKAMHHSRSRSHHVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HNW4</accession>
    <name>A0A8J2HNW4_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA polymerase alpha subunit B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HICCMSTLAB_LOCUS13050</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DNA polymerase alpha subunit B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5108063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HNW4"/>
    <dbReference type="OrthoDB" id="336885at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005658">
        <property type="term" value="C:alpha DNA polymerase:primase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.530">
        <property type="entry name" value="DNA polymerase alpha-primase, subunit B, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007185">
        <property type="entry name" value="DNA_pol_a/d/e_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043034">
        <property type="entry name" value="DNA_pol_alpha_B_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016722">
        <property type="entry name" value="DNA_pol_alpha_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054300">
        <property type="entry name" value="OB_DPOA2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013627">
        <property type="entry name" value="Pol_alpha_B_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23061">
        <property type="entry name" value="DNA POLYMERASE 2 ALPHA 70 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23061:SF12">
        <property type="entry name" value="DNA POLYMERASE ALPHA SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04042">
        <property type="entry name" value="DNA_pol_E_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22062">
        <property type="entry name" value="OB_DPOA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08418">
        <property type="entry name" value="Pol_alpha_B_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0235">DNA replication</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA polymerase alpha subunit B N-terminal" evidence="8">
        <location>
            <begin position="6"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="domain" description="DNA polymerase alpha subunit B OB" evidence="9">
        <location>
            <begin position="475"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="domain" description="DNA polymerase alpha/delta/epsilon subunit B" evidence="7">
        <location>
            <begin position="529"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="399"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="399"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="411"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="447"/>
            <end position="460"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF22062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAG5108063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="767" mass="87926" checksum="0581FF56633065D3" modified="2022-05-25" version="1">MEFKDKLQDNFRLFECKLVDESVLTKFVEICKDFEVDEDGIVESWVEFVNGDENESSTDITTEKVEAFESWFKKNIDKRCAKPDLPSDSGTESTAEELSNLDKSIKNKGSEILERSILNVSTIKTEEDDDILEMYGRKKNPSKILSYYEDCEMFVRDHWLQAIGHSWKRSKYFFFPLFNINVPDAISQLPVAGVASLPRGSATPTLRVLFLLDLIFIPAQVLLIFDFEQIQYETSFADPEVHEDKENDDEDIDASTIQSRSGEIVLKFGFALSDWNNVSPHKSKVQRTDFPHASPIEAHLFVQMKDYSVLNDLCRLMSRVFCEIWLKDKEQLVITSNVREKTFNKFRTWGRIITDNDGKLTTTSILLMGDPDHWYHSLGEYETEDYEDNEVDDNIEIVESEESDEEDSDEEKERRGEVKVKEEREEEEEGGGGKETGLKEEDEDEENEKKKETEEEKESLGDPVIIDIRTRKECIPLDVSRLKCYSFFPGQIISVEGKNPTKDTLCAYRVIPGISFGPKPPVLNEPLHIMVAAGPFTSKPGNYQQLYNLMAHVAQTEPNVLILIGPLMTEKDIVPPKKDMFENLITKIMSYVDGKSTQVVLVSSYEDVLHDGFYPTPEYRLRESVKKPNLHLMPDPCTIEVDGLIIGITSVDIIRHLSSEEISYKMPQRDRLGRLAEHLLLQSSYYPLFPPAPEVPLDLLLWAECSTMNVHPHILLVPSAMQYFYKYSNGTHIINPSKVSKGLYTQFNVRSNDQWTENSIGGEILRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HQH8</accession>
    <name>A0A8J2HQH8_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">ABC-type glutathione-S-conjugate transporter</fullName>
            <ecNumber evidence="13">7.6.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">HICCMSTLAB_LOCUS13333</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>leukotriene C4(in) + ATP + H2O = leukotriene C4(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:38963"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57973"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:38964"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.6.2.3" evidence="13"/>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5108630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015431">
        <property type="term" value="F:ABC-type glutathione S-conjugate transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18595">
        <property type="entry name" value="ABC_6TM_MRP1_2_3_6_D1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18603">
        <property type="entry name" value="ABC_6TM_MRP1_2_3_6_D2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03250">
        <property type="entry name" value="ABCC_MRP_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03244">
        <property type="entry name" value="ABCC_MRP_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000293">
        <property type="entry name" value="ATP binding cassette subfamily C member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000001">
        <property type="entry name" value="ATP-binding cassette subfamily C member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000074">
        <property type="entry name" value="Multidrug resistance-associated protein 5 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000041">
        <property type="entry name" value="Multidrug-Resistance like protein 1, isoform C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005292">
        <property type="entry name" value="MRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056227">
        <property type="entry name" value="TMD0_ABC"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00957">
        <property type="entry name" value="MRP_assoc_pro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF443">
        <property type="entry name" value="MULTIDRUG-RESISTANCE LIKE PROTEIN 1, ISOFORM I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24357">
        <property type="entry name" value="TMD0_ABC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 19" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="12 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-1278">Translocase</keyword>
    <keyword evidence="6 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="36"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="70"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="105"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="134"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="171"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="291"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="346"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="418"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="445"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="523"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="572"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="963"/>
            <end position="989"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="1025"/>
            <end position="1050"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="1086"/>
            <end position="1105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="1111"/>
            <end position="1131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="1196"/>
            <end position="1217"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="18">
        <location>
            <begin position="307"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="17">
        <location>
            <begin position="621"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="18">
        <location>
            <begin position="972"/>
            <end position="1253"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="17">
        <location>
            <begin position="1292"/>
            <end position="1524"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="889"/>
            <end position="910"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00024220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="CAG5108630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="1530" mass="172210" checksum="5FACC3FD5D5441CA" modified="2022-05-25" version="1">MENNTMDLFCGSTFWDLNVTWNTTDPDLTPCFQNTVLVWSPCIFLWTFSLLEAYYLINSNRKNIPYTWKFISKGVLTAALIVLSIVDLSVAIHNSNYTTVFNVDYYTPFIKIITFGLALLLLHYNRKCGMRTSGLLFLFWFFLAICGAVQFRSIIRNYKDQPELPYSFGSYFVYYPIVLILFLLNFLVDAEPKFSRYGQVDRPCPEQSASYPSKILFGWFDSLAWKGFKKPLTTSDLWSMNPEDTASEIVPKFNKYWTRNLKKCDNSQGTKASFRKASGQVDFNSTRKKKVASVIIPLYRIFGPTFFFGALLKLSQDIMTFISPQVLGLLINFINSKDEAQWKGYFYSVLLLLTAILQTLVLSQYFNRMFIVGMRMRTALVAAIYRKALRMSNTARKESTVGEIVNLMSVDAQRFMDLMPYINMIWSAPLQIGFALYFLWYELKYAVFAGLAVMIFLIPINAVIANKVKTLQIRQMKSKDERVKLMNEVLNGIKVLKLYAWEPSFEQQILKIRNKEIKVLKEAAYLNAGTSFVWSCAPFLVSFVSFATFVYISDDNILDSKTAFVSLSLFNILRFPLSMLPMVISNVVQAMVSIKRINSYMNGEELDPNNVQHDQSELHPLIIENGTFAWGPESLEKPTLKNINMQVHHGQLVAVVGTVGSGKSSLISAFFGEMDRISGRVNTKGSIAYVAQQAWIQNATLQDNILFGKPLDKALYAKVIDACALGLDIKMLPAGDQTEIGEKGINLSGGQKQRVALARAVYTDCDVYFLDDPLSAVDSHVGKHIFENVVGPNGLLKKKTRVLVTHGITYLPDVDNIFVLKDGEITESGTYKQLMEKRGAFADFLIHHLQEVKPEDEAVPELTEIKQQLESTIGSEELQQKLTKARSRLSMTHSESGSIDQKSLNGSLHRQQSIDSQKSVNLMRSTSIKENSLPIKGEKIIEAEKTETGSVKLRVYAHYLKSIGWFLSVSTIVMNAVFQSFSIGSNIWVSKWSDDTEMFVNGTLDRVKRDTYVGVYGALGIGQGILSIVISLLFAIGPISASVFIFQGLLTQVLRNPMSFFDSTPSGRLLNRFGKDTDVIDNIIPMILRTWLNCVLSVIATLVVISYSTPIFIAIIVPIGVLYYFIQRFYVATSRQLKRLESVSRSPIYSHFGESITGAQTIRAFNVQERFIYESERRVDFNQMCYFPGIISNRWLAVRLEMVGNMIIFFAAIFSVAGRDSLSAGLVGLSVSYALQITQTLNWLVRMTSDVETNIVAVERIKEYGETPQEAPWEIPSTAPPKDWPSEGRVEFRDYKVRYRDGLDLVLNGLSFSVNGGEKVGIVGRTGAGKSSLTLSLFRIIEAAEGKIFIDGIDISELGLHALRARLTIIPQDPVLFSGTLRLNLDPFDIHTDEQIWQALEHAHLKAFAKTLPNGLMYLVSEGGDNLSVGQRQLICLARALLRKTKILILDEATAAVDLETDDLIQRTIREEFKDCTVLTIAHRLNTILDSDRVIVLDKGVITEFDKPENLLQKPTSAFYSMAKDSGIVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HQX2</accession>
    <name>A0A8J2HQX2_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Similar to sel: Protein seele (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HICCMSTLAB_LOCUS11561</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the canopy family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5103541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HQX2"/>
    <dbReference type="OrthoDB" id="192915at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.225.10">
        <property type="entry name" value="Saposin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042415">
        <property type="entry name" value="CNPY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021852">
        <property type="entry name" value="DUF3456"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13341">
        <property type="entry name" value="MIR-INTERACTING SAPOSIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13341:SF2">
        <property type="entry name" value="PROTEIN SEELE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11938">
        <property type="entry name" value="DUF3456"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035155995" evidence="3">
        <location>
            <begin position="20"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3456" evidence="4">
        <location>
            <begin position="34"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="182"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF11938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAG5103541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="202" mass="22796" checksum="0D50437229739FD8" modified="2022-05-25" version="1">MRLNIFMVVLLFFIVAINAQYDFDTSEVHADELKCVVCRATIKEIENALAEIDPSRQIEVGSRIDAHGNMVNKKVPMIESETHFSEILENVCAKLDDYVRARYKSNKKLTILNLISPSGGMNPDMGKVNIVQDSDLNKSLRFTCEEIIDDNEDYITSIFKKGSSDTVNHICTRSLSLCEDLDADSETDDKDGDDYEDAKDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HR42</accession>
    <name>A0A8J2HR42_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Similar to Sarnp: SAP domain-containing ribonucleoprotein (Mus musculus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HICCMSTLAB_LOCUS11608</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the SAP domain-containing ribonucleoprotein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5103635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HR42"/>
    <dbReference type="OrthoDB" id="5837849at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016973">
        <property type="term" value="P:poly(A)+ mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.720.30">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003034">
        <property type="entry name" value="SAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036361">
        <property type="entry name" value="SAP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052240">
        <property type="entry name" value="SAP_domain_ribonucleoprotein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46551">
        <property type="entry name" value="SAP DOMAIN-CONTAINING RIBONUCLEOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46551:SF1">
        <property type="entry name" value="SAP DOMAIN-CONTAINING RIBONUCLEOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02037">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00513">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF68906">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50800">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <feature type="domain" description="SAP" evidence="4">
        <location>
            <begin position="13"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="96"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="142"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="96"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="154"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00046328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAG5103635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="230" mass="25685" checksum="FA7FA8B7FB4B4EF9" modified="2022-05-25" version="1">MADSSYEKGLSELSKMKVADLKVELKQRGLPTTGNKNELVERLQLAIHGDSALSLDENAEEILDEDAVLERKLSTDANPVSAKKIVLNRNSVIEEIKVDKPSDEEPPKSVEAAEPQKRVIKLSEVGIKERLEMRAKKFGVPLSESAKKEARSARFNSSNQSDKSAASIKIPVETSVETLKKRAERFGTVSNVVEKVELLEKIEKRKARFGEVEVQSIKKPTFVNRVKYVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HRE2</accession>
    <name>A0A8J2HRE2_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS13911</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5109275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HRE2"/>
    <dbReference type="OrthoDB" id="8061146at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140996">
        <property type="entry name" value="Hermes dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5109275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="121" mass="13909" checksum="4BB296A5C97E1FA7" modified="2022-05-25" version="1">MVRSESPLKTCIWEVENSNIDDSSDDSVVRHLSLKRKNRSGSYEENNNCTTTCNTDGVITLSTVKLKKNTPKINSFIDKISETEHSKLDEALSYFFFSKNLPFDLVEDEYFIKFCKTLRPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HRN3</accession>
    <name>A0A8J2HRN3_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Chitin-binding type-4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS12044</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5105994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HRN3"/>
    <dbReference type="OrthoDB" id="64893at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004302">
        <property type="entry name" value="Cellulose/chitin-bd_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21113">
        <property type="entry name" value="AGAP001705-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21113:SF4">
        <property type="entry name" value="CHITIN-BINDING TYPE-4 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03067">
        <property type="entry name" value="LPMO_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-4" evidence="2">
        <location>
            <begin position="25"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5105994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="231" mass="26182" checksum="5474459C08397FDD" modified="2022-05-25" version="1">MILLSSNNFFFYFQSTIILPVVFGHGMLMDPVNRGSAWRLGFDTPVNYNDNENYCGGFNVQYNQNKGQCGLCGDDYRLKTPRPNENGGIYGTKTIVKTYREGQEITVNVTLTSNHRGYFEFSLCPLLYQTNTNINNNSLSSSIIELEETEECFKQNPILTVDGKNKYILSSYENGNYQVKLVLPKGIICDQCSLRWQWRVANNWGICHDGTGAIGCGPQETFRTCSDIRII</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HSL0</accession>
    <name>A0A8J2HSL0_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS12543</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5107015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HSL0"/>
    <dbReference type="OrthoDB" id="7268706at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37449">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37449:SF1">
        <property type="entry name" value="OS02G0159950 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5107015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="136" mass="15263" checksum="198C8BC02BC6E984" modified="2022-05-25" version="1">MKFSTVQRDIINVSDDDREVEIQSYDLIYQDAREPDPMYQHARRKTSLTILGPSPRYFWTNSEPTTRMKAAVVCLATALASIVLPQPGGPYIKTPRGGSIPICLYNSNLKHGNTRVSFGWQDINESIAVLMKSNTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HSX1</accession>
    <name>A0A8J2HSX1_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Dynein axonemal light chain 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HICCMSTLAB_LOCUS12741</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Cilium axoneme</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the dynein light chain LC1-type family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5107422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HSX1"/>
    <dbReference type="OrthoDB" id="266138at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005930">
        <property type="term" value="C:axoneme"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030286">
        <property type="term" value="C:dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043014">
        <property type="term" value="F:alpha-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045504">
        <property type="term" value="F:dynein heavy chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036158">
        <property type="term" value="P:outer dynein arm assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000049">
        <property type="entry name" value="Dynein light chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025875">
        <property type="entry name" value="Leu-rich_rpt_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15454:SF73">
        <property type="entry name" value="DYNEIN AXONEMAL LIGHT CHAIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15454">
        <property type="entry name" value="NISCHARIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12799">
        <property type="entry name" value="LRR_4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0966">Cell projection</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="6" id="KW-0243">Dynein</keyword>
    <keyword evidence="3" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="4" id="KW-0493">Microtubule</keyword>
    <keyword evidence="7" id="KW-0505">Motor protein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAG5107422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="194" mass="22625" checksum="E80D620FB48B2660" modified="2022-05-25" version="1" fragment="single">NFYKLEYFQAKSTSCKEAIEKWENETGKKASVEKEVLLSFQWPPIEKMDHHLSFLKNVEMLSLSTNIIEKISNLDSLKNLKVLSLSRNNIKTLSGLDSIGDHLEELWISYNFIEKLKGVHVLRALKVLYMGNNLVKDWNEFNRLQDLSNLEELVFANNPINENLEVESWRSQVIRKLPQLKKLDAIPIIHEDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2025-06-18" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HTV7</accession>
    <name>A0A8J2HTV7_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Similar to NGEF: Ephexin-1 (Pongo abelii)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HICCMSTLAB_LOCUS13437</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5108801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="27593at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01221">
        <property type="entry name" value="PH_ephexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00160">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11793">
        <property type="entry name" value="SH3_ephexin1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047271">
        <property type="entry name" value="Ephexin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047270">
        <property type="entry name" value="PH_ephexin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12845:SF5">
        <property type="entry name" value="EPHEXIN, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12845">
        <property type="entry name" value="GUANINE NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="DH" evidence="5">
        <location>
            <begin position="917"/>
            <end position="1103"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="4">
        <location>
            <begin position="1252"/>
            <end position="1313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="211"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="396"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="526"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="779"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="832"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="220"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="402"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="535"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="563"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="788"/>
            <end position="800"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAG5108801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="1343" mass="151283" checksum="2A6C6223A4E101A4" modified="2022-05-25" version="1">MPVILIGGEIKLCEVMQLQRTPSVVNSDNNNHYDKLLLNNIACKTMGSRTINSTVLHNRSFLHGDIVVVSDDKHNNKNTIDSLALRRASLPLQLVPNDIVCIDNNTDFISDDNDSSVSFSVYDSSTSIVSQLDSKDGDDSWENKTETKLDHKFTITRPKRYCPSSKFGSNSNKKRFIVKPRWIFTRTVLHYVPKHKRTRKLINNILPISKYKDTNKDNNKQNNSNNNNNNNNNNNNKYNWPKRNVSLPSNFVHVAGVRRWSWLENVDDNSMQIINHKEKCATLTLINDKRKNSLIQMGDDDEFICKRSSSAETLVGENIKEPVTIFNKRQTTVSITGSSRRNSDEHLVKTNNESDDTYDDVGVPELCVNGSVNYEDEQVYDDVMLVRDSLPVKVPTIEKENSGSSCSSSGSGNEHDKNADKVSANKAQVVNGRNFREIEKEEYKEEHDLIYMRNNYSTVDEDADDEVTVYDDVGVVLCESRVNSIYAGSINIGQLDPSKESEWEDLDENSSINGLSKNLRALLRNASDNQNAWSNKKKSGQRRTRKVRRQRSKASRKNSARSTNRVSRPSTVSVAVSLGTGSVLIVGPTASGEDTNPQTWRDCGPTNLKDVNHLKCTTLDQLTTTTCTSSSTTTTKNFKGTNNAQGLVQLRTVESEDGDEALVDIQETSCYVLEGFFEGDSSANTGSDDSNYETLYSFEPYESNQVDPINSGSQLFNSSDGKSNKNLTVDLIDESTRERINLSAPLRPVPPPPRESSLTGTFGKRMKMLKRTWSITKGSLGRMRRRTSGSMETDSNTDDFNTKSSQVFNFKKHFQRSSAAMSTFYLDNDNDTSVRNNNNNNNNNNSASTSTSCDDIYENSYWINANYSKRDGNAVDDYNILSEEPLYQFYAASTFRGAFQSDSDSYGDTEDSLPSASELEAKFEIITSEASYLNSLRVLVNEFLINHELVYEALSATDREKLFGSVPSVLIASERLLAELESVWRADPMLKGLPEVLLKHAERCSKIYTDYCSNQVSIDLTLKELRSKKSSKFVETVNRIESHPACQSLSLHSFLMLPMQRVTRLPLLADAVLSKLSTEHEERLDWEKVLSVLGRVVTECNEGARLAGRQIEMASLAKKIEYTTKVPSIDLRDRYLVRSGPVTQILAKPGTEYVLTFRKKFHKTPLYLLLNQDEVYSVIDSCKRSLIALEKVPDDSPFAGRHAMILTLLDNYCSRHVEYILSCQNATERERWLDAVSPPKPNLVGETLYETWDCPQVMALYSYTPVQPDELSLQPGDMINVLKKMADGWNLGEKLVGGEQGWFPGNYTKEVASEHVRAKNLRQRHRLLALSESLLQQYAKQSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HTW3</accession>
    <name>A0A8J2HTW3_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="22">Similar to Nsd2: Histone-lysine N-methyltransferase NSD2 (Mus musculus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">HICCMSTLAB_LOCUS13406</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5108770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HTW3"/>
    <dbReference type="OrthoDB" id="422362at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140938">
        <property type="term" value="F:histone H3 methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016279">
        <property type="term" value="F:protein-lysine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd21991">
        <property type="entry name" value="HMG-box_NSD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15564">
        <property type="entry name" value="PHD1_NSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15565">
        <property type="entry name" value="PHD2_NSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15566">
        <property type="entry name" value="PHD3_NSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15567">
        <property type="entry name" value="PHD4_NSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20144">
        <property type="entry name" value="PWWP_NSD_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05838">
        <property type="entry name" value="PWWP_NSD_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19173">
        <property type="entry name" value="SET_NSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.140:FF:000099">
        <property type="entry name" value="Histone-lysine N-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006560">
        <property type="entry name" value="AWS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047443">
        <property type="entry name" value="HMG-box_NSD2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055198">
        <property type="entry name" value="NSD_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059153">
        <property type="entry name" value="NSD_PHD-1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055197">
        <property type="entry name" value="PHDvar_NSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003616">
        <property type="entry name" value="Post-SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000313">
        <property type="entry name" value="PWWP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050777">
        <property type="entry name" value="SET2_Histone-Lys_MeTrsfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22884">
        <property type="entry name" value="SET DOMAIN PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17907">
        <property type="entry name" value="AWS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23011">
        <property type="entry name" value="PHD-1st_NSD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22908">
        <property type="entry name" value="PHD_NSD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23004">
        <property type="entry name" value="PHDvar_NSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00855">
        <property type="entry name" value="PWWP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00570">
        <property type="entry name" value="AWS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00508">
        <property type="entry name" value="PostSET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00293">
        <property type="entry name" value="PWWP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63748">
        <property type="entry name" value="Tudor/PWWP/MBT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51215">
        <property type="entry name" value="AWS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50868">
        <property type="entry name" value="POST_SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50812">
        <property type="entry name" value="PWWP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="12" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="11" id="KW-0862">Zinc</keyword>
    <keyword evidence="10 14" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PWWP" evidence="19">
        <location>
            <begin position="144"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="17">
        <location>
            <begin position="615"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="16">
        <location>
            <begin position="726"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="domain" description="PWWP" evidence="19">
        <location>
            <begin position="775"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="domain" description="AWS" evidence="21">
        <location>
            <begin position="903"/>
            <end position="953"/>
        </location>
    </feature>
    <feature type="domain" description="SET" evidence="18">
        <location>
            <begin position="947"/>
            <end position="1072"/>
        </location>
    </feature>
    <feature type="domain" description="Post-SET" evidence="20">
        <location>
            <begin position="1079"/>
            <end position="1095"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="59"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="308"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="348"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="430"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1229"/>
            <end position="1270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="71"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="312"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="437"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="1259"/>
            <end position="1270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="CAG5108770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="1270" mass="143909" checksum="62F42020B394731E" modified="2022-05-25" version="1">MDTTSDKQVESDYHDHKKMDINGDKVVKLKKNGKLSISNANSSTSRYGRTIRHVIQSNDNKNIDNQTLKLPKPEPKKNNLSVRKSDGNKVVSNSNKDVEMSVSDDTSHAGDNISVVSLETLEASEEILMKKSWWKKPDDTLWKPGQLAWAQVSTFPYWPCVITLDPDLNRFVKWRAFGKSVSNMIHVQYFGDKGRHNWVAEASLMPFLGLASFKKLVQEWYALPDSVRKKDLKKTAGYRVKPYISAKWSIAVQEAEPLLAMELEERLNALKPQRKRERSDNSINLETKKVKLDNIKEKPKIRIRLKNPNIEVKNGAKNNLKNGVKNGKLNSNDSKKPDIDDDARSVISVDGEIPPTPPSSHKDSSDESIVIRKVKIKRIKKVVEPIPSFDIYYNRNKEGVANVSPDSTEDDIKTYLKKSWENMSEQARMKYIPQVSERSKQSSTDRETNFSDEPAPKRKRGKKNSIGKDESIVETVKKARIPNLFRGTKAERVCQICEKTGNLIRCKGPCYSHFHLKCVKPGESESECSTEVEDNVDDKSLESSKIDDKSVKNNKIEDKSVKNNKIEDKSVENTKIEKSDSVVVVDEEENNKKDSQTEEETFKCIDCLSGVAPACFVCNEREDERIKCSVMACGKHYHAACLKYWPQSQLQGDRLNCPYHTCHTCISDNPQNGYSRAPNEKIIRCVRCPSAYHASTTCLPAGSEIITGSQMICPKHYKASHPPLNATWCFLCTRGGSLICCDTCPTSFHADCLGINAPDGAFICEDCETGRLPLYGEIVWVKLGTYRWWPSRICFPHEIPSNIQAVSHKPGEFCVIFLGTLNYYWVHRGRVFLYQDGDSNVKSSVNKSGVDGAFREALKEANELHERLKSEKKEDELRAIKPPHFVKLKINKPVGNVKPADVDSIVACECDPNWDTPCDANSDCLNRILSIECSPGICPAGSKCCNQSFARREYPAMEPFHTRARGWGLKTLENIKSGQFVIEYVGEVIDEAEYKRRIKTKKELRNENYYFLTIDNYRMIDAELKGNLSRFMNHSCQPNCETQKWTVNGDTRIGLFALRDIEVGEELTFNYNLASDGEKRKPCLCGAPNCSGFIGLKAQKLSLTPTTTGPQIKSKRGRRPRMIYKCWRCSKDLSDREEFVICDLRTCSKRYHKKCVTVQGDASKFSCPWHHCLECNKRCKKHCTYCPIAYCQIHEDSDDLDLQKSLPPEIKVDSDNDIEADRESLLADSDSPISELLPKESSPRVSIAEVPTNSEDSEISVKKDNEDNKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HU21</accession>
    <name>A0A8J2HU21_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Similar to Edg78E: Pupal cuticle protein Edg-78E (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HICCMSTLAB_LOCUS13589</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5108953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HU21"/>
    <dbReference type="OrthoDB" id="7781803at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062129">
        <property type="term" value="C:chitin-based extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008010">
        <property type="term" value="F:structural constituent of chitin-based larval cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031311">
        <property type="entry name" value="CHIT_BIND_RR_consensus"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050468">
        <property type="entry name" value="Cuticle_Struct_Prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000618">
        <property type="entry name" value="Insect_cuticle"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10380">
        <property type="entry name" value="CUTICLE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10380:SF109">
        <property type="entry name" value="CUTICULAR PROTEIN 49AH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00379">
        <property type="entry name" value="Chitin_bind_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00233">
        <property type="entry name" value="CHIT_BIND_RR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51155">
        <property type="entry name" value="CHIT_BIND_RR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0193">Cuticle</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="54"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="55"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="66"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="76"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG5108953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="87" mass="10021" checksum="DD62141D57D63194" modified="2022-05-25" version="1">MGSYSYTSPEGQLISVHYTADETGFHPVGDHIPTPPPVSEEIQKGLDLIYAGIRKQQEESAHEQQLKQQQPYNQQIDRHEDNKKYRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MA93</accession>
    <name>A0A8J2MA93_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS2682</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001117">
        <property type="protein sequence ID" value="CAG5078233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MA93"/>
    <dbReference type="OrthoDB" id="8190250at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012464">
        <property type="entry name" value="DUF1676"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21879">
        <property type="entry name" value="FI03362P-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21879:SF23">
        <property type="entry name" value="IP06949P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07898">
        <property type="entry name" value="DUF1676"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035222882" evidence="2">
        <location>
            <begin position="20"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="147"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5078233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="241" mass="26918" checksum="63C491F1947CE79E" modified="2022-05-25" version="1">MKFIYCGLILLLVATYGACLRDYRDPWKGLPMLCAKEDPRNVSLSCHGVRIVKRVIQELLERAASTKRIQITDGISIVDNSVDDMHSMDRRGRTLKSTVLGLFEGKELRIKLSSLMPFDLESLTSDEQGRRRNDYGLGGGKKGNNNIFILALLMGKMLGIIGFGTLGFLTMKALMASSLALMLSIVLAAKKFSASSQPSENHIVYAAPAPVEPHRRKRQIEDLNLSPYRGWLQTYNNRKSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MBQ2</accession>
    <name>A0A8J2MBQ2_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="21">Multiple epidermal growth factor-like domains protein 8</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">HICCMSTLAB_LOCUS2803</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001117">
        <property type="protein sequence ID" value="CAG5078660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="263283at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048513">
        <property type="term" value="P:animal organ development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048731">
        <property type="term" value="P:system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00041">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00055">
        <property type="entry name" value="EGF_Lam"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000191">
        <property type="entry name" value="Multiple epidermal growth factor-like domains 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000202">
        <property type="entry name" value="Multiple epidermal growth factor-like domains 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000214">
        <property type="entry name" value="Multiple epidermal growth factor-like domains 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.290:FF:000023">
        <property type="entry name" value="Multiple epidermal growth factor-like domains 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.290">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056737">
        <property type="entry name" value="Beta-prop_ATRN-MKLN-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000859">
        <property type="entry name" value="CUB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000152">
        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018097">
        <property type="entry name" value="EGF_Ca-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002049">
        <property type="entry name" value="LE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056863">
        <property type="entry name" value="LMN_ATRN_NET-like_EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049883">
        <property type="entry name" value="NOTCH1_EGF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016201">
        <property type="entry name" value="PSI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035914">
        <property type="entry name" value="Sperma_CUB_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46093">
        <property type="entry name" value="ACYL-COA-BINDING DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46093:SF16">
        <property type="entry name" value="MULTIPLE EGF-LIKE-DOMAINS 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24981">
        <property type="entry name" value="Beta-prop_ATRN-LZTR1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00431">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07645">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00053">
        <property type="entry name" value="EGF_laminin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24973">
        <property type="entry name" value="EGF_LMN_ATRN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00011">
        <property type="entry name" value="EGFLAMININ"/>
    </dbReference>
    <dbReference type="SMART" id="SM00042">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00180">
        <property type="entry name" value="EGF_Lam"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00423">
        <property type="entry name" value="PSI"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49854">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00010">
        <property type="entry name" value="ASX_HYDROXYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01180">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01187">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01248">
        <property type="entry name" value="EGF_LAM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50027">
        <property type="entry name" value="EGF_LAM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="10 13" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 13" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="12 14" id="KW-0424">Laminin EGF-like domain</keyword>
    <keyword evidence="9 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 17" id="KW-0732">Signal</keyword>
    <keyword evidence="4 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035156054" evidence="17">
        <location>
            <begin position="24"/>
            <end position="3000"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="2848"/>
            <end position="2870"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="18">
        <location>
            <begin position="50"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="19">
        <location>
            <begin position="1303"/>
            <end position="1344"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin EGF-like" evidence="20">
        <location>
            <begin position="1426"/>
            <end position="1480"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="18">
        <location>
            <begin position="1478"/>
            <end position="1640"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="19">
        <location>
            <begin position="1669"/>
            <end position="1705"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="377"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1195"/>
            <end position="1222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1530"/>
            <end position="1555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="1196"/>
            <end position="1219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="1542"/>
            <end position="1555"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="1448"/>
            <end position="1457"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="1695"/>
            <end position="1704"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="CAG5078660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="3000" mass="334692" checksum="C556FEB43B79FD4B" modified="2022-05-25" version="1">MMGWTKVMSIWAVTWAFCLIVRGLVNPSSLPLSSGSSPSMSQQNVKQVPCDKTRKIFTNSWGVISDGPMGSNYTQDSHCEWLIKANNSRQFITLSFRTMGTECSYDYVFVYDGDSFRSPLLGSFSGKTEPQQVTSSSGYMLILLYSDTNYVLDGFHAEFSVTDCPNNCTRHGKCINNTCVCENDWGGKDCSRELCPNNCSEAGTCGVKRCQCRKGFSGQSCSLHATHPDGNKWHWLSHSEGGMTPRAAHTAIYDSKTDSLYVFGGYNLNYVLSDLQVYRFNTSQWENEFGQVLEGASAAEYLDPMLIAGELERIGLNGAEEKYGISSSSLVWKVLSNIKNSSSSFNFRDSIRSAADSGDNNWREFIGGPDYHFTRPARKKRQVPVETTPLPDDDDDDMVVIKVNDNENQEKQILKSHPSPRYGHAACKYKNGFVIYGGKLANGSLSNHLWHYNIETRVWTLRARESGLIPPPLTRHTLTLAGDDYDQKNGFIYLFGGSTVDGEFSSSLYSIKLNFTHPEEEQWRQLVVRGGKELDVRVVAHSTVYHKATNSLLVYGGVVASVARFSKLSDRMFVFQLNRKVWSEIHYPRAHLRDTYVPRERAFHTCNIVGNYLVVFGGYSHRHNKEEICYDNQMYLYHLGCHVWISHEVFGVTDHRDGAGYPKQQGVFAHAADVRNGNTLLLVGGYHGNVNADLLAYTLPPMLAPGDGDYTGAEPEQLCFKHKTFTECSANPECGWCSADEICYGRTIGSNCTTNLQTSRCPGVCPALGDCHSCLIHGQPSSGTGNWGTNSRGKISISNKLNLGTCTWCVQNARCHHKDDNYGVCGLRDDTLSQIPGWWGPKGTEIVRVDECRELDRRPGLTFLKYKPPVNFTQPDSVTIVNATTIDFNVPSMQGAKTESGLGGEMIARLTGFLRLPQYFWDDSAENLKICVSYNSATLRVTHNLDDRDSSDEKLEFVANLTAETSQCIPTKWPDGTKMSLQPNGRYFLDFESKRMVTVNYAYPSKMEITHSKKSENPKVFTFEYLEPYQNGTCSQYSNCLHCLTDSSCGWCELNNKCLSRALNETESCLTTVEYNHKNITEWRYLTITPSTCANCSNYITCESCVTTSLCEWWTEEARCARIGRLPNSILSVDQCPIPCRHRTNCTQCLDEKGRCVWCEATHECFSFSVYTSEYQFGLCREWMDQAGLMGVTSRSSSSSSSSSSSSSSSSSSSSSSSSDQGFSSGNYQCKSCSRHTNCTNCLHSLSCGWCYSLDNPITGVCVQGDFNRPHVNCSLAINDYYAINETTLINRESGWAYAQCPDVDECDLGLHDCHPNAICTNTHGSYSCQCKRGFNGDGRENCTKTCYEKCVNGYCSEAPDYKCECNLGWTGPDCKTNCGCYNHSTCISAVGVCDECQDWTTGQYCEECKAGSFGNATTSLGCRKCNCNEHGDRDIDYCDRQTGKCFCKDNTEGEMCEKCKKGYYGDPKNGGMCYYGCMSRGMLTGPQGGMTGKQGLGSRYSQLSLWESHLAGSPTRECLWIVRPSNGQLMTNSSDDNNNNDNDDDDDDDDDDDIAPQSIIQFTINEDINVSCQENSVYVYDGLPDFVSSTSSHQSQLLGVYCTESTNYPVTVEAKSGTLTVHYKQLDEVEGFNASYIVMTCGINCPENRECRNGQCLCKVGFVGIDCDVELCPNNCTSSKKQGVCDKSYGHCVCAVGFGGRDCSIKLKSHQLVFTELFNSEYLADNLDHLRKTLPRFGHSLVADRRGSLWMFGGYSLSHGPLNDIRLFDTRNNTWMPVTVESTSEASMPQGRYFHAAEIVHSRQQIYVYGGLSRKEEVPPPLAGHTLTLRRNAESESLILIGGFSPKYGYLDSVWEFNLETELWSVMTTRGNGPLGVYGHSTVYHTKSDSLYVFGGYTYAVNRTFISNKLYALNYKTYTWSVLPPFNDNNDNTEVGSLPQARFLHSAVTTDEYMVIFGGRQNPYNTNDSLIAYEYACNLWIRLITKDTEIIGIPPPPAYAHAMTHADPEVNAIYVVGGFDGGINSHVTQINIPDDLCNLWTEKIVCRKYFGCSFCSVITIAGNNESYCFSNQQSSATHRVDKCNTNVTMSQRSNGVYCNYEWMASRKCQNLKSCTECLAQWPYYRDNEDEDDEDVTPICKWCTNCPTPYGKCIPAEKDCDEQNKCNSRQVSIMDVNQCGERQCPASDCEKCSKLDEDCVWTRQVLKTSDTCLKHSHCGWCSLDSTNITGQGICTEGSLEAPTDHPAGGTCEMLFNQLNPPTEPITTTVMPHDFTDAIVIEQDFIDLITNETFSIVNTKMLFSWHYVRCPPENECINGHHTCSAKSEKCFDLDEGFECMCGDGYKNETTWSTSLSFSSSSSSSSMLTLPSMNEYGRKMCVPMCTQGCVRGTCIEPNVCRCDFGYVGANCSIQCQCNGHSNCAGPDKLDVCLKCHNNTMGAQCDKCEPLYVGNPADNGQCVPCLEYCNGHTRICINESMTVSDPNSVDRMSIELLQKQLIEGPVAKAKCVNCGNNTRGDKCGECVSGYFRGTEDLRDVCRPCECHGHGNTCDPVTGEKCNCGNNTESEPLCTSGPSKSGNPGGGKPCWMVQCSKCRENYAGNPTMGHQCYKTVTVDNKMCFDSKLIDECKLKPKPLNPGQTVFYMVQPRFMNVDIRIMVDVTQGALDLFLSPRDDSFVVTINSTTGYQDVELDGRFKWRKDHYDNWFEDDHSMLDRIRIVEFHPHSPYSPYSPYSPYSPYSPYSSMINSSGQVEQTNWNNGPQFLVMERYASDNLATFVTIEQRNTFLVIRNLTNRLVLTLPEDKHELGLTKFHIALRAIDPPYVVDSAGGRAAYGMIFFRQDQLHIDLFVFFSVFFSCFFLFLAACVVAWKTKQAADVRRARRRHVVEMLHMAKRPFASAIILYDNRDGNLGDSPTSPQQRKPARLARNKIVNFHSDVRPVAVEPTDDGVAAVATVFIRLPGGPHAPVKLALGSSLILLTRVYPVNSRVFLRRRNSHAVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2ME10</accession>
    <name>A0A8J2ME10_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Mitochondrial (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS4309</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the mTERF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5085217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2ME10"/>
    <dbReference type="OrthoDB" id="637682at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061668">
        <property type="term" value="P:mitochondrial ribosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006390">
        <property type="term" value="P:mitochondrial transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.70.10">
        <property type="entry name" value="Transcription termination factor 3, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003690">
        <property type="entry name" value="MTERF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038538">
        <property type="entry name" value="MTERF_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13068">
        <property type="entry name" value="CGI-12 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13068:SF112">
        <property type="entry name" value="TRANSCRIPTION TERMINATION FACTOR 3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02536">
        <property type="entry name" value="mTERF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00733">
        <property type="entry name" value="Mterf"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5085217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="369" mass="42974" checksum="9C34D38166667CBF" modified="2022-05-25" version="1">MTACIKNLSYLKLKSILTSLKQVSLQIRNLSAVPSLELNHTDTVKPVTTDINLVEYPEIDESEYLSDKVVSKMKIPSALDPSTEDLSYLGPELKPTFNFAAYANQSPTIQELVKLGVQLWRIETNQESMACILKRNFEDLRPYIQFLHDCGVPPEEIGRFITKNPRIFEQDMDDLKTRIRYLRAHNFSRDNIARIVTAHPPWLSFPTKFIDKRLGFFQREFKLTGEQVRFVTLRKPALITFKGNQLRENIFSVREQMGFYPSEMKAILLNKPAVYTTERRLTLPTFEYVHNEMMISHDIIAQMPIILRTTLERIKSRHLFLKALKRDQYDPTKPLYVSLDDIASPTDYVFCYKSARASIELYDMFLRSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MEN3</accession>
    <name>A0A8J2MEN3_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similar to TkR86C: Tachykinin-like peptides receptor 86C (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS4521</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5087469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MEN3"/>
    <dbReference type="OrthoDB" id="5981855at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0675">Receptor</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5087469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="102" mass="11830" checksum="655EC00072E977C7" modified="2022-05-25" version="1">MTSDNLNRLYNCSAKILDQNLTILQELNRSELLSVLDQVLSSDNRNLLRVNFTDCLFTGQERPFDLPWWQKLSWSCVFAIMLIVATGGNIIVMWIVLEYMTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MFZ2</accession>
    <name>A0A8J2MFZ2_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Polycomb group RING finger protein 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HICCMSTLAB_LOCUS2789</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001117">
        <property type="protein sequence ID" value="CAG5078606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MFZ2"/>
    <dbReference type="OrthoDB" id="1305878at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031519">
        <property type="term" value="C:PcG protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17083">
        <property type="entry name" value="RAWUL_PCGF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000073">
        <property type="entry name" value="Polycomb group RING finger protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000033">
        <property type="entry name" value="Polycomb group RING finger protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051507">
        <property type="entry name" value="PcG_RING_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032443">
        <property type="entry name" value="RAWUL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45893">
        <property type="entry name" value="POLYCOMB GROUP RING FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16207">
        <property type="entry name" value="RAWUL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13923">
        <property type="entry name" value="zf-C3HC4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="11">
        <location>
            <begin position="22"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00072766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAG5078606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="230" mass="26874" checksum="760B2514D25F8A2B" modified="2022-05-25" version="1">MVLTGAMERRIKLKTLNSHITCKICRGYLIDATTVTECLHTFCKSCLVKHLEEKHTCPTCQIVIHQSHPLQYISFDRTMQDIVYKLVPDLQENEIKREREFYRARGLPCPKDVLPNAGDVEDEKASADAHAEADYHRADEQVNVCLECVNTNLKTLKRRFIRCSAQATITHLKKFIAKKVLNGMEKYRDIDILCNDELLGKDHTLKFVYVTRWRFRDPPLRLQYRPRIDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MIQ7</accession>
    <name>A0A8J2MIQ7_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Similar to SLC41A1: Solute carrier family 41 member 1 (Pongo abelii)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HICCMSTLAB_LOCUS7030</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLC41A transporter family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5093704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MIQ7"/>
    <dbReference type="OrthoDB" id="6514723at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:monoatomic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.20">
        <property type="entry name" value="SLC41 divalent cation transporters, integral membrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006667">
        <property type="entry name" value="SLC41_membr_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036739">
        <property type="entry name" value="SLC41_membr_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045349">
        <property type="entry name" value="SLC41A1-3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16228">
        <property type="entry name" value="DIVALENT CATION TRANSPORTER SOLUTE CARRIER FAMILY 41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16228:SF7">
        <property type="entry name" value="SLC41A_MGTE INTEGRAL MEMBRANE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01769">
        <property type="entry name" value="MgtE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161093">
        <property type="entry name" value="MgtE membrane domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="31"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="67"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="SLC41A/MgtE integral membrane" evidence="10">
        <location>
            <begin position="3"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAG5093704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="98" mass="10458" checksum="4AD8684BC86F930C" modified="2022-05-25" version="1">MVVGLLASLAAVIFGWIPEAHFNIHHGLLLYVSALVPASVASFLLGLVMVAVILLSKRMNINPDNVATPIAASLGDLTTLALLSWVVSYLYRSINNQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MJD5</accession>
    <name>A0A8J2MJD5_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Aquaporin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HICCMSTLAB_LOCUS5367</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MIP/aquaporin (TC 1.A.8) family. AQP11/AQP12 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5089763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MJD5"/>
    <dbReference type="OrthoDB" id="1580043at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015267">
        <property type="term" value="F:channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1080.10:FF:000018">
        <property type="entry name" value="Aquaporin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1080.10">
        <property type="entry name" value="Glycerol uptake facilitator protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051883">
        <property type="entry name" value="AQP11/12_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023271">
        <property type="entry name" value="Aquaporin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016697">
        <property type="entry name" value="Aquaporin_11/12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21191">
        <property type="entry name" value="AQUAPORIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21191:SF16">
        <property type="entry name" value="AQUAPORIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017529">
        <property type="entry name" value="Aquaporin_11/12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81338">
        <property type="entry name" value="Aquaporin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="37"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="67"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="109"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="151"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="185"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="228"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR017529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAG5089763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="263" mass="29368" checksum="CF262701C247A133" modified="2022-05-25" version="1">MGASLIALFVSTVYIVLTSWLAFWARKYAKFYTQRPFLRALFLEGIATAELCGACFELIIIADNWGVSMYAIYLFVLTIWWSKVWEDATACPYTHLEELVEGKKSLRDAFLLIWAELVGGLAIFRYIQLLWALEIVSTHKNRAFDDCSTDLQVPVIFGAIVECIATCICRVVSRGLSELDSKLGTVIDAFIGTTLVVAAFNYSGGYFNPALATSLKYGCLGTTFMEHVIVYWVGACAGSILSIRVYQHPAIQSFVQKHKPKSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MJL0</accession>
    <name>A0A8J2MJL0_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS5518</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5090177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MJL0"/>
    <dbReference type="OrthoDB" id="6700395at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035153161" evidence="2">
        <location>
            <begin position="21"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="152"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="205"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="98"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="152"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="206"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5090177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="225" mass="24598" checksum="A8ED0471F172FD47" modified="2022-05-25" version="1">MQLNFLFLLAGTLIWQSTDAHPASYDQRQTGDLNVQLGFKDIQVVALMDTDLLGDYVDYNYSYDYADFTIKPASKPTTTAGPTSSVEPWHTWPTIPPSSSTTLSSSSSSSLQSSSSLEPDAISPSSSSSSSSTTTTISSITSNDSLEIEKITSSTETNKNPSKINRRDSLSKFDCPSGYSSDAKGRCRKIIRRRLSFLPRLMKLGPKKEGTSKDLRAAPWISETQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MJL9</accession>
    <name>A0A8J2MJL9_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Similar to ZNF425: Zinc finger protein 425 (Macaca fascicularis)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HICCMSTLAB_LOCUS5549</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5090238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MJL9"/>
    <dbReference type="OrthoDB" id="6077919at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000446">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24376">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24376:SF216">
        <property type="entry name" value="ZINC FINGER PROTEIN 420-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13909">
        <property type="entry name" value="zf-H2C2_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="20"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="49"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="77"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="309"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="537"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="566"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="625"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="653"/>
            <end position="680"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAG5090238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="713" mass="82188" checksum="B1306D06161FBD28" modified="2022-05-25" version="1">MSFDESSGPESSASSKKQSFKCKICKKFLATAKTLKQHEKDIHADAKCYPCKQCDYVTYREANLKRHLLSHTKEKPYKCSVCSFSCSLEQNLKQHMLAKHSEERPQIIELNDDDSDSSSVVEIECVLAPRKTDRNVTQNEGNFIDTGLPNPNQIKITRIESLSGKEHYWTDDVKPIKPATLPEVLTPPDDSSSNSLLKFQQNSATGQFNLVLPKEEETTEFAEESETINLSSDLDYYNGEFNSTLRHHKIYQCMECDFAAFSKMSFKTHTEAHNNNNSFKCPKCPFIAINKSTFRSHFICKHSNVKKPFQCQICHFSTYFQSALQQHIKIHGADRSYECQYCPYAAITKSYLAIHLHNHFTQPKYPCSNLKDRNPLKNRLVDGITFEKAVSKRFNFKKPIINNDTWKKKILEFKLDKNIISNDVISENFNNPSFPVILPDNVSVLEELNQEELSQQSSELESTCNENPRLYNLLNAKFHAQAECLPVVLLERIQVPEKIVNTSTVNVESLKKPNQNSVDKNSSSFKKSKPAINKKEHECEQCDYKCKRKRDFINHHILIHSSDPPFKCPKCSHKTKRLADLRKHIKVHHNNEFPHTCPHCSLGFTELIQLNNHNHRCSFAAEKLFECEICKKRLATPNTLSTHKRTFHSAGSFTCSICQKKLGDKYSLELHRKTHKNGQTFTCQNCPFQTVYTTSLKRHWSRHHKDKNSLINK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MKW3</accession>
    <name>A0A8J2MKW3_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">PHD-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HICCMSTLAB_LOCUS5716</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5090679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MKW3"/>
    <dbReference type="OrthoDB" id="10002605at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="6">
        <location>
            <begin position="339"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="115"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="124"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAG5090679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="389" mass="44331" checksum="8BDF770631F438AE" modified="2022-05-25" version="1" fragment="single">STTNHEFNTRTSVTLKSLNIDKTKYNNDLIYDDKYFKCVVNPKRSDKIKFEKENPGVKVIECPAHLTFRTTKDKQALVITQFEPNHDHDSSNKISRLKEAKDKIIANTIRSANITHSEEINEPSASSSQSNLQNKQQIHSSVITGANDEVTSSTLQVASTITDDEIPYAPVIDDDDDDFKFLLKQLDLNIASSTDEEKQMRKISLLTEIINKYNDIDVASKIGTLSVCLSRSRGRNRGRKNRVASFPENTRNILTFDELSVVKKKIYLIKLILNDKNLIESVLTKLKKISTAELTHLIPNIPDALGSETIKFEILEEFFEKDAFKSFKKSVSKKRESPHWSCNQCEKDLGTSDSIECDKCLFWSHFVCVDLVQEPPNTWFCPKCKSEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MLM1</accession>
    <name>A0A8J2MLM1_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Similar to Collagen alpha-2(IV) chain (Ascaris suum)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">HICCMSTLAB_LOCUS7288</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5093962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MLM1"/>
    <dbReference type="OrthoDB" id="8626508at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005581">
        <property type="term" value="C:collagen trimer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000328">
        <property type="entry name" value="CLUMA_CG000981, isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008160">
        <property type="entry name" value="Collagen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003112">
        <property type="entry name" value="Olfac-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050605">
        <property type="entry name" value="Olfactomedin-like_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23192:SF85">
        <property type="entry name" value="GLIOMEDIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23192">
        <property type="entry name" value="OLFACTOMEDIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01391">
        <property type="entry name" value="Collagen"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02191">
        <property type="entry name" value="OLF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00284">
        <property type="entry name" value="OLF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51132">
        <property type="entry name" value="OLF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="16" id="KW-0176">Collagen</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="7 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="23"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="14">
        <location>
            <begin position="316"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="14">
        <location>
            <begin position="411"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="domain" description="Olfactomedin-like" evidence="15">
        <location>
            <begin position="582"/>
            <end position="842"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="164"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="172"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CAG5093962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="868" mass="96183" checksum="42BF02CB69B8E55E" modified="2022-05-25" version="1">MSAMQTGRDNEPGPKFVGLQTNILIYLVLSQFLIQIGTFIYLCAYISRLESEIQDLVAQVADDDAENTIEGTNDSVRRKRSSALPLSEDNAVSEVFRIRNEKDSVKEMKRGTIPPDGAPGDAISSLVPNSDSWVWLTADTRVPFDAMDALCRKSAEFCPPGLPGIPGPPGVPGDRGLPGISGPIGPEGPPGIPGYTGERGPRGEPGPPGFDGRDGIPGEPGLDGIPGRSGLDGIPGTDGKAGRDGIPGLPGRNGTDGKRGLKGSTGLPGPQGPPGARGERGIPGTPGKDGTPGMPGVVAWEVRRNDSRSNELLIPPSILSENLPRHVTSVPERSYLQLQCGASGNPRPVIQWSKTSGAAIPIGSWHHSSVIGTILNITVVNREHMGEYMCIADNGIPPRASYKFRLEVQFPPFIRVCHQTIRVQLGGMAILECDIEAFPEPSVWWERDDGKPLEQSPKHRMEVYDKRDLYKFKMRLNITKITYQDHGSYHCAAKNVMDITKGTVMVYDGTKRVSMDSGELRREVVYGERPPKKVDIHDICPPQLSCDNCPQNKCGFSDFGGCFDIRQLVSNVNYTGLSPRQGVGILEAVGKPVFKGNMDDTHGYWMYDALPRTESISEKLWVTRSNNSWYIFEYNKKDDVKRGQSRSIRLPYPFKGNGHVVYNGSFYYNPENRSSIYRLDLGSAQSTHNKPQYHMELILPGLRINDNNYLYSRDHDSSYVDFDVDENGLWVIYGLPLNYTAVLKVDTVNMRAQQAWNISIDHHRFGEMFIASGVLYAVHNVTGPSLEIRLALDLYRHAILDVHLSFSNPFRKTTMIRYNHKMKELYTWDKGNLLAYPLYISLISRGYKASACHCSPIKKNIEIKTMYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MN30</accession>
    <name>A0A8J2MN30_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ITPR-interacting domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HICCMSTLAB_LOCUS8091</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5096201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MN30"/>
    <dbReference type="OrthoDB" id="6088188at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005102">
        <property type="term" value="F:signaling receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029325">
        <property type="entry name" value="ITPR-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043444">
        <property type="entry name" value="TESPA1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17469:SF15">
        <property type="entry name" value="ITPR-INTERACTING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17469">
        <property type="entry name" value="SPERM SPECIFIC ANTIGEN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14722">
        <property type="entry name" value="KRAP_IP3R_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01257">
        <property type="entry name" value="KRAP_IP3R_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ITPR-interacting" evidence="3">
        <location>
            <begin position="103"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="296"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="374"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="532"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="299"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="316"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="379"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="393"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="403"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="572"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG5096201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="572" mass="64990" checksum="2F11C19419312CD5" modified="2022-05-25" version="1" fragment="single">QTIICFLENVGKEAIIRVTDWLRGIWEMRRNGGPVQQWVDSIPSPTKSSIDIHIESHDSSSSLIPEEHHHLKKVTSLKNPIMTLSAPSSPAIAMSSIPSFPRSRLVRDPSLQSDSSHCSSVESLLELRKPDPEAILLGLGFGGGSNNSQAEGPLSRIPKRFLQPSKLRGIAIDEFMRQQQETNESIDTASLGYRGLTGSPYVAPSEIVQKIMERLREHESHESDVQSICNNNNNCNTESYNSQAIPEVRLSVLSPNNRQFLERERSRSPDMRNKRMIIGQKSFAFNGDGDLIEIINSKNHRDSTSENSTDSKNDLKNSYTPSSITAHPDYTFQKYDNEKTEKLKRKITKQKSVEELFDSSLSESDFSLIEPKFSEDDFNSNNNLNTVENNSRQSRKYIRGVRSKKEHEETPSNIRRASDGAHIVDEKHSSHSSEEGRRFSDGIIKSTLKPASDRRRSFRRQARINDVEAASYENDCNHCERLESEVKSELSCNLERRDLCCESDESEQVCRHDAESKDCCCHASNTSCWRKMRKMMKKNQKLENMVVKSRQEMAEIRGMLSTVLSVRMEPGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MNZ1</accession>
    <name>A0A8J2MNZ1_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to aktip: AKT-interacting protein (Danio rerio)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS7515</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5095050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MNZ1"/>
    <dbReference type="OrthoDB" id="5596422at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd23814">
        <property type="entry name" value="UEV_AKTIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UBC core" evidence="2">
        <location>
            <begin position="63"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="241"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5095050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="279" mass="32180" checksum="2DF1FB6045E403FD" modified="2022-05-25" version="1">MTSKPPGSSSKSDNEGDEGFKRTGSFRKILPGTSCGDSQLNTSIKMIDRPNVAQNNMDYAVYLREYSILSEYKLMQTQDLKGVYVIPSAQNPFLWFGVLFVRQGMYQGGVFRFIITLPDIFPDGDCPKITFKTKVFHPLIHEETGEFSTSAGFSDWKKSNRVFHLVQFITKVFNKIDPKLKAINEEAYNLFENNIEEFRKKVKQCVKDSLDHVYDSPETDDAHYLKFSPWDPEIHEPIRQKLYESRQQQPLDPEKSPRGYSWVQPGSLKPLSKSEEDLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MPJ1</accession>
    <name>A0A8J2MPJ1_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to Sodium/calcium exchanger regulatory protein 1 (Doryteuthis pealeii)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS9499</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5100329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MPJ1"/>
    <dbReference type="OrthoDB" id="412780at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00742">
        <property type="entry name" value="FABP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012674">
        <property type="entry name" value="Calycin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031259">
        <property type="entry name" value="ILBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000566">
        <property type="entry name" value="Lipocln_cytosolic_FA-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11955">
        <property type="entry name" value="FATTY ACID BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00061">
        <property type="entry name" value="Lipocalin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50814">
        <property type="entry name" value="Lipocalins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lipocalin/cytosolic fatty-acid binding" evidence="2">
        <location>
            <begin position="6"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5100329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="116" mass="13630" checksum="F6DBE27B6785855C" modified="2022-05-25" version="1" fragment="single">MSKILGKYQHERSENLDEYFKTLELPYLVRKMINMSNPKIEVTKEGDKWIVTTVTMMRTQVWEFTLGTEWEEVMPSGVKLQNTTTIEDDSLIIVSITEDGNRTIRRYDFNDDGMTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MQ20</accession>
    <name>A0A8J2MQ20_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Calcium-transporting ATPase</fullName>
            <ecNumber evidence="18">7.2.2.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">HICCMSTLAB_LOCUS10105</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="18">Catalyzes the hydrolysis of ATP coupled with the transport of calcium.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>Ca(2+)(in) + ATP + H2O = Ca(2+)(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18105"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.2.2.10"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="18">Membrane</location>
            <topology evidence="18">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.2.2.10" evidence="18"/>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5101032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MQ20"/>
    <dbReference type="OrthoDB" id="116380at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005388">
        <property type="term" value="F:P-type calcium transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051480">
        <property type="term" value="P:regulation of cytosolic calcium ion concentration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02081">
        <property type="entry name" value="P-type_ATPase_Ca_PMCA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1110.10:FF:000001">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1110.10:FF:000002">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1110.10:FF:000013">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000002">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000007">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022141">
        <property type="entry name" value="ATP_Ca_trans_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006068">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006408">
        <property type="entry name" value="P-type_ATPase_IIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01517">
        <property type="entry name" value="ATPase-IIB_Ca"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24093:SF369">
        <property type="entry name" value="CALCIUM-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24093">
        <property type="entry name" value="CATION TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12424">
        <property type="entry name" value="ATP_Ca_trans_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00689">
        <property type="entry name" value="Cation_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08282">
        <property type="entry name" value="Hydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00121">
        <property type="entry name" value="NAKATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00831">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 18" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10 18" id="KW-0106">Calcium</keyword>
    <keyword evidence="6 18" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="13" id="KW-0112">Calmodulin-binding</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="16 18" id="KW-0406">Ion transport</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="17 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 18" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-1278">Translocase</keyword>
    <keyword evidence="7 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="15 18" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 18" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="92"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="130"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="292"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="335"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="783"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="860"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="898"/>
            <end position="918"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="938"/>
            <end position="957"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase N-terminal" evidence="20">
        <location>
            <begin position="32"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="233"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU361146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="SMART" id="SM00831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="CAG5101032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="1058" mass="116069" checksum="22E489790E40919C" modified="2022-05-25" version="1">MATIDGRPAQYGVSLKQLRELMEHRGREGVNKINALGGVQEICKKLYTSPSDGLSGSSADMQHRRDTFGSNSIPPKPPKTFLTLVWEALQDVTLIILEIAALVSLGLSFYHPTPKAEDDDVKLDEDEAKYGWIEGLAILISVIVVVLVTAFNDYSKERQFRGLQNRIEVDESSLTGESDHVKKGEAFDPMVLSGTHVMEGSGKMLVTAVGVNSQAGIIFTLLGAAVDQQEQEIKKMKKGDEAGEITGNSHPGSGGSVKQDGENHAAASSGGGGGHGEGKKEKSVLQAKLTKLAIQIGYAGSTIAVLTVLILIVQFCVKKFYIQKAQWESSYINNLIKHLIIGVTVLVVAVPEGLPLAVTLSLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTTNRMTVVQSYICEKLSKTIPPFSDIPSHVGNLIVQSISLNSAYTSRIMPAADPTELAMQVGNKTECALLGFVLALGQNYQTVRDDQPEETFTRVYTFNSVRKSMSTVVPKSGGGYRLFTKGASEIIMKKCAFIYGRDGHLEKFTREMQDRLVKNVIEPMACDGLRTISVAYRDFVPGKAEINQVHCEGEPNWEDEENIVNNLTCLCIVGIEDPVRPEVPEAIRKCQKAGITVRMVTGDNINTARSIALKCGIIKASDDFLILEGKEFNRRIRDSNGEVQQHLLDKVWPKLRVLARSSPTDKYTLVKGIIDSTCTASREVVAVTGDGTNDGPALKKADVGFAMGIAGTDVAKEASDIILTDDNFSSIVKAVMWGRNVYDSIAKFLQFQLTVNIVAVIVAFIGACAVQDSPLKAVQMLWVNLIMDTLASLALATELPTPDLLLRKPYGRTKPLISRTMMKNILGQGIYQLTVIFTLLFAGDKMLDIPTGLDSEDKHSSTPTQHFTIIFNTFVMMTLFNEFNARKIHGQRNVFQGIFTNPIFYSIWIGTMLSQVVIIQYGKMAFSTKALDLEQWLWCIFFGIGTWGRGQPDDIGAINLGDEKFDPDSDKKPRAGQILWIRGLTRLQTQTSNRSLVQNVSVTGRSPSQDYYMPAEPIRETEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MQJ3</accession>
    <name>A0A8J2MQJ3_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Similar to IntS9: Integrator complex subunit 9 (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HICCMSTLAB_LOCUS10662</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. INTS9 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5101761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MQJ3"/>
    <dbReference type="OrthoDB" id="5600060at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032039">
        <property type="term" value="C:integrator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034472">
        <property type="term" value="P:snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10890">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022712">
        <property type="entry name" value="Beta_Casp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027074">
        <property type="entry name" value="Integrator_9su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46094">
        <property type="entry name" value="INTEGRATOR COMPLEX SUBUNIT 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46094:SF1">
        <property type="entry name" value="INTEGRATOR COMPLEX SUBUNIT 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10996">
        <property type="entry name" value="Beta-Casp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16661">
        <property type="entry name" value="Lactamase_B_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01027">
        <property type="entry name" value="Beta-Casp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-Casp" evidence="7">
        <location>
            <begin position="296"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="559"/>
            <end position="581"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG5101761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="610" mass="68796" checksum="580EA83ECCADDA42" modified="2022-05-25" version="1">MLDCSLNMQSILNFMPIPMVPSGKFNALPNWLPRDTHHNHYHSQTPYQQYHSQEWKIEGELKECCGRVFVDSIPEFSPPLEKIIDFSEIDVILVSNYTCMMALPFITEATGFKGIVYATEPTLQIGRFFMEELVQYIEQTPRTTLAKYWKEMLHILPSPLADAVKPKSWKQLYSMNAVNSALSNIQLVGYDQKLDIYGALTVTPISSGYCLGSSNWLISCEHEKVAYVSGSSTLTTHPRPMEQTTLKHSDVLILTGLTQTPTANPDTMLGELCMAVAMTLRSSGCVLIPCYPSGVVYDLFECLSTHLDKIGLTQIPLFFVSPVAESSLAYSNILAEWLSTNKQNKVYLPEEPFPHGFLVKNARLKHFTSIWQGGFSTEYRQPCVVFCGHPSLRFGDAVHFVQLWGNNPQHTIIFTEPDFPYLEALAPYQPLAMKAVHCPIDTSLNFTQANKLIRDLKPDNLVIPECYTQPPYTAPHRLDLIIEPVAPEKPLITFRRGEVTKLPLKRSKSRIFIEPKLASSIIPSQIRPGLSLASITGELEIKDNVYTIKSIEPQQQLIGRGKRKIQDASSSVDTKDSKDGENFKEKDLRHEYVLMGRRNHTCNKCDVCAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MQJ7</accession>
    <name>A0A8J2MQJ7_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS10332</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5101259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MQJ7"/>
    <dbReference type="OrthoDB" id="10070859at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="173"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="202"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5101259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="356" mass="37663" checksum="07D4A209F5D5E282" modified="2022-05-25" version="1">MAGALSENAPRPVSVVTVDGGTPQTVEPPPETTIQENSNANGVRCFASTEAQTDMGLTSRVEGINPGCDDLRDARRRERRVRRHHRRAMRSCSMPPTYPGGPGCVQANAGVGTAPGMPLVPPVGGYLHPPPPHLGLRGLSLGLPFPVPASVSAFGRDAVPKQCCGLGSPPVRWSILGVGIVGLVCAAAGALLGALRATGRDHIAVSLLMIGIGVVLLTVSGVAWRVTSRENCGSFFGFTGISARIPPARPMHPYAAMIYPEFQFRTPPPSYQASMQEYRLRLLLLDRLQPTSSPPPTYRSNAASIIAPCTTRESRPPSYCGRGNVTPNATLAPSTKKDANLVRIVQTESEPLSVIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MSP9</accession>
    <name>A0A8J2MSP9_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Similar to to: Protein takeout (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS12959</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5107881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MSP9"/>
    <dbReference type="OrthoDB" id="8189372at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.15.10.30">
        <property type="entry name" value="Haemolymph juvenile hormone binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010562">
        <property type="entry name" value="Haemolymph_juvenile_hormone-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038606">
        <property type="entry name" value="To_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11008">
        <property type="entry name" value="PROTEIN TAKEOUT-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11008:SF31">
        <property type="entry name" value="PROTEIN TAKEOUT-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06585">
        <property type="entry name" value="JHBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00700">
        <property type="entry name" value="JHBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5107881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="180" mass="20270" checksum="53694DA8822ED1E3" modified="2022-05-25" version="1">MFPGLPQLGYPEVEPIVLDEVHISLGGGPDGYKAQFRDVAAKGVSALRITGLRTRITDDEVQLQLALHIPKIRAAAKYRSNGVKAKVFIRAKPFLVEGHKYLRLQQLKMDFSVENIKMGVENVHDGNTILQAALNLFINSNSQELLKEMKPDLRRKLVQVMTSFVEKLFAQVPYDAWIID</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MTE4</accession>
    <name>A0A8J2MTE4_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Venom protein 80-6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HICCMSTLAB_LOCUS9376</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5100084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MTE4"/>
    <dbReference type="OrthoDB" id="7674659at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004185">
        <property type="term" value="F:serine-type carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001563">
        <property type="entry name" value="Peptidase_S10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802:SF3">
        <property type="entry name" value="RETINOID-INDUCIBLE SERINE CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802">
        <property type="entry name" value="SERINE PROTEASE FAMILY S10 SERINE CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00450">
        <property type="entry name" value="Peptidase_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035263648" evidence="7">
        <location>
            <begin position="22"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG5100084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="415" mass="47500" checksum="FBDC38143A0A351E" modified="2022-05-25" version="1">MKNIYISILIFYLLQAKEVKSDEEKGVGSTKQNWSYVTVREGAHYFWWLYHTSSSEATSKNKPLLISLTTGILKAASGVNNFDQIGPLDIDLNPRDKTWLKDFNILFIDNILDCGFSYVDNETNYPSSSDQMGEDTFAVIKDFLNKVPEFRTIPTYMMSENVGTVIAAKTASIWGQAQKNKQIESNLKAVVLGAPWISLVDVVNFWAKPSNKDKFSEEEFKEIEERARNATEAEKKGEYWEMFSSSFAAQIVFLRNHFKLNNIFNLSPSVTTNYSDVEKDDKLKSLMNNHVKNVLRLGHEWKNDADYSAMVNFGEKTAKPIKQTFDQILKTDVRVVVITGENDLFIPAPTVISWVNSFNWENKEAFQAARQVDIDNKISMKKYGNLEYYIIEAGHLLIVDNPQDLKKVIIRVTQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MWK8</accession>
    <name>A0A8J2MWK8_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS9897</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5100824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MWK8"/>
    <dbReference type="OrthoDB" id="2311693at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd14733">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="136"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5100824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="212" mass="24281" checksum="3090C1C97C594C31" modified="2022-05-25" version="1">MFDQENKWYSEGVYPNAEQRAVCGNVVIKASLDGMGPSVDIMIKKSNTKPAFVTIELKVYVNSTKGKWMRKDFKDWTDTCSINGIPVHVDYQLIRKGLYVDVNVELKIYWHGHIANHISPNLFDNIKDYMNKPEFSDVTVCVKGEKKYLAHKIILAAQSPMLEKMLIMLNFELATAHNSSILRQSSLTFILNNYEKVKKSNEFAALSRKIDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MZJ1</accession>
    <name>A0A8J2MZJ1_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Similar to Usp54: Inactive ubiquitin carboxyl-terminal hydrolase 54 (Mus musculus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HICCMSTLAB_LOCUS12857</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5107665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="205782at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02257">
        <property type="entry name" value="Peptidase_C19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052398">
        <property type="entry name" value="Ubiquitin_hydrolase_53/54"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22975:SF9">
        <property type="entry name" value="ECHINUS SPLICE FORM 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22975">
        <property type="entry name" value="UBIQUITIN SPECIFIC PROTEINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="USP" evidence="5">
        <location>
            <begin position="31"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="10"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="43"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="356"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="460"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="530"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="668"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="768"/>
            <end position="898"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="950"/>
            <end position="1020"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1123"/>
            <end position="1183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1240"/>
            <end position="1265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1277"/>
            <end position="1308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1644"/>
            <end position="1671"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1872"/>
            <end position="1945"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="1190"/>
            <end position="1234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="10"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="371"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="466"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="536"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="676"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="775"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="814"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="826"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="844"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="883"/>
            <end position="892"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="971"/>
            <end position="981"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="988"/>
            <end position="1012"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1241"/>
            <end position="1265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1288"/>
            <end position="1303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1654"/>
            <end position="1665"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1872"/>
            <end position="1884"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1895"/>
            <end position="1932"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1933"/>
            <end position="1945"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAG5107665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="2056" mass="229618" checksum="37827B54FA232DB9" modified="2022-05-25" version="1">MLKWIKVKQDTASVAKETSNSKVVSKGTENDDIEPEIEVACKADDGEAAAKKEEEEDSGMEREDSPAIDLRRLKKDLFSQLQFSQDSALPPDALRQALAKSFLDQQRFQLGFMDDAAECFENILLRIHLHIASGEAEDMCSARHCVPHQKFAMTLVEQSVCGACGATSEPLPFTQMVHYVSASALTSQARQTLPAAKNSPDLFGQLLRKAGGMGDIRDCPSACGAKIQICRTLMNRPEIVSVGVVWDSERPSLEHIMDVFATVGTCLRLSDVFHSVVDSRWGASTVHNLVGVVTYYGKHYSTFFFHTKLKVWIYFDDATVKEIGPRWEQVVEKCRRGRYQPLLLLYATPGGTPVNTENAPKVVTPFPNTKGWKTSPQKNNSRRSVTPSPEKPLISNTARRAITPNPDSAQPHAYTQRRVYSDYQNLTDIQNNIFGIKDVDTVDGESESKYISRRAVENVMQHQKKQQMQLTRSLSAGSNTQDGLSIPDHLNVPRRRDSGNWSGDRNSASSSSSTTMDNPYLYIVHKMQRNSGVPKSPTSKSGELSSSSSGHYDAGYDSYSLSSTDSLTIQQSLKHNLQLAQIPEGYQSTVGSDCERLCKETDALLEKSRAAEDAGDLGTAVALCSAAANKARAAMDAPYNNHNTITAARLKVNTCVMRSRSLHRRILQEHAIANGGKEEAAADGRHTRENSKSGQHSRQNSRDKGNHSRQNSRELLINTTPVIDKPAVKNIEIYATLPKKKTLRGKATAVNVIEDEEYMLYDKPTQRTGFFGRTKRCDDDKKEKKRARSEERNKNISKDFSIAPSKPSVSPKNTKPDKTCKETSDSSKSSQSNTTSAAVDQKQGKKQHKIRRKLLMGGLIKRKNRSMPDLREGQDGQPIAATKENTSNTLPKQSVDDSNVGLKANEVGQSLSGYLSEGHLEFAGNCNANPNLERSRLMRKSFHGSAGKALHVAKVPPPPPLRTTSQLSKSKCPEVRNEQDNINKSSYNNNNNNNNNINNNNNNQINGNINNNDGQCAITSPQDQTTNAYWSHLNPANFDSNSQLCRNNYDEYLSEPQSLPFLPSYNSEGNNLMTSPVNVNQQQQLPQNGPAKPRIQDDVVQYANGILYEPTFVVTRADVHNEQSPVKGQQLEVLPPYPENMTNVSHSRQPSEDFPPPPYPVIPSVNHSRQPSEDFPPPPSPLEIENTLLYQQQQQQQQQLQLQYLQQQQQQQQQQQQQQQEQQQQINIQQQQQQLKHRQHQQLQQQQQPSQQMQMQASQQQSMEAQQISSLLAQLQSKRAQVMSSENVEEKKRNSTHEDEDKNGSGTWLRELQSKLGERKMKKQGPLDGQDVPKSIARRTSDLMMNSVGPITNQPQGVDVTDCPRVISSVKDMAARFEQIKLHPTPKVDLDGKVQLKLTSNSVSPSPTMGNSNEVQKTEETINQLPLSSENLAAFTKFDNYTSLTSSAESTSSQSTFVALPSDNSSSNHQQTSGLNAAILSMSLTLPHETGLPIDYPEDDISEVAMQNTIQNTTILPMEADLLVAKTKRRSGKKKSVSFCNEVVLVAAADDDIKHSEYPHPILERVLRSTINKPESVQVMREIQSLKEAEMNRDSNQVTRFQQHTLPLKNEADSTPSTTFQDQLRSVNPIIPLPVDSNLRPTFTRQNPTDPPVNTNTSTSITQQQEPKKYTPYVGSDCHSDVIRDSYPPAVSSSAQSKMSYSPQLQQQIRYAQNGLTYNQSSSSLSTQGYTQLHPSHPCNPAVPVSQTQKPASPYTVQMHNQYPQVNIQQQQQQQQQQQLIMNNNNSAQKNGYPVYYHLDQQHNQMNLQMTNQQFQQNGTNRTQSVNSSPITVQNPQQFGYQTNQSQNSYQQYPTQNQYSSNNYQGYTLQNGAQQSRASPSIPQYQPPPNLAVYQSQQSQSQLTSQKNLPQNPQNQQLQSHHQHQMAQAFQQRGENYQRPPQKTDQQNILAPNQMYTNSLQNGQSNIKLQNYQHPPANSAVAIKALKQGPLLTNGKSNSMSLLQPANPMQKTISAPAISRATLPVKCNLCRLKPATETGMFCVNCDKFVNRSWSKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2N0A5</accession>
    <name>A0A8J2N0A5_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Guanine nucleotide-binding protein G(s) subunit alpha</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Adenylate cyclase-stimulating G alpha protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HICCMSTLAB_LOCUS13449</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Guanine nucleotide-binding proteins (G proteins) function as transducers in numerous signaling pathways controlled by G protein-coupled receptors (GPCRs).</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 12">G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 12">Belongs to the G-alpha family. G(s) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5108813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2N0A5"/>
    <dbReference type="OrthoDB" id="5817230at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005834">
        <property type="term" value="C:heterotrimeric G-protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001664">
        <property type="term" value="F:G protein-coupled receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031683">
        <property type="term" value="F:G-protein beta/gamma-subunit complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007191">
        <property type="term" value="P:adenylate cyclase-activating dopamine receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007606">
        <property type="term" value="P:sensory perception of chemical stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00066">
        <property type="entry name" value="G-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000720">
        <property type="entry name" value="Guanine nucleotide-binding protein G(k) subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.400.10:FF:000003">
        <property type="entry name" value="Guanine nucleotide-binding protein G(S) subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:006178">
        <property type="entry name" value="Guanine nucleotide-binding protein G(s) subunit alpha isoforms short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.400.10">
        <property type="entry name" value="GI Alpha 1, domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000367">
        <property type="entry name" value="Gprotein_alpha_S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001019">
        <property type="entry name" value="Gprotein_alpha_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011025">
        <property type="entry name" value="GproteinA_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218:SF212">
        <property type="entry name" value="G PROTEIN ALPHA S SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218">
        <property type="entry name" value="GTP-BINDING PROTEIN ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00503">
        <property type="entry name" value="G-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00318">
        <property type="entry name" value="GPROTEINA"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00443">
        <property type="entry name" value="GPROTEINAS"/>
    </dbReference>
    <dbReference type="SMART" id="SM00275">
        <property type="entry name" value="G_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47895">
        <property type="entry name" value="Transducin (alpha subunit), insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51882">
        <property type="entry name" value="G_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 10 12" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5 11 12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 11 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 10 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0564">Palmitate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 12" id="KW-0807">Transducer</keyword>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="57"/>
            <end position="62"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="61"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="190"/>
            <end position="196"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="196"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="215"/>
            <end position="219"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="284"/>
            <end position="287"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="360"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU369121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAG5108813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="388" mass="45082" checksum="5A6BCBA897D7F247" modified="2022-05-25" version="1">MGSCVSVMGCFGSQSSKASQDDSRNQKRRSDAITKQLQKDKQVYRATHRLLLLGAGESGKSTIVKQMRILHVNGFSETEKRQKIEDIKKNIRDAIVTITSAMSTLTPPVTLEDPSNQSRVDYVLEVSSSPDFDYPPEFYEIVETLWKDRGVQQSFERSNEYQLIDCAKYFLDKVAIVKKPDYSPTEQDILRCRVLTSGIFETRFQVDKVNFHMFDVGGQRDERRKWIQCFNDVTAIIFVTACSSYNMVLREDPTKLRLRESLDLFKSIWNNRWLRTISVILFLNKQDLLAEKVKAGKHKLEDYFPEFCRYQTPVEPGVVAEPTEPPEVIRAKYFIRDEFLRISTASGDGKHYCYPHFTCAVDTENIKRVFNDCRDIIQRMHLRQYELL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2023-09-13" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>S6D2Y6</accession>
    <name>S6D2Y6_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cc_single_15.5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">CcBV_15.5</name>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS6181</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Philos. Trans. R. Soc. Lond., B, Biol. Sci." volume="368" first="20130047" last="20130047">
            <title>Functional endogenous viral elements in the genome of the parasitoid wasp Cotesia congregata: insights into the evolutionary dynamics of bracoviruses.</title>
            <authorList>
                <person name="Bezier A."/>
                <person name="Louis F."/>
                <person name="Jancek S."/>
                <person name="Periquet G."/>
                <person name="Theze J."/>
                <person name="Gyapay G."/>
                <person name="Musset K."/>
                <person name="Lesobre J."/>
                <person name="Lenoble P."/>
                <person name="Dupuy C."/>
                <person name="Gundersen-Rindal D."/>
                <person name="Herniou E.A.Drezen.J.M."/>
            </authorList>
            <dbReference type="PubMed" id="23938757"/>
            <dbReference type="DOI" id="10.1098/rstb.2013.0047"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5092512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="HF586473">
        <property type="protein sequence ID" value="CCQ71233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S6D2Y6"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036441355" evidence="1">
        <location>
            <begin position="23"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5092512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCQ71233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="61" mass="6841" checksum="9D47F581E6B2341E" modified="2016-04-13" version="1">MASALLMLSRLVCMLVVVAVNARLDYDWSPLSFETHYSRDSRDGGWGSGLFKMVLSGWNDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2EAU6</accession>
    <name>A0A8J2EAU6_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS187</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030000990">
        <property type="protein sequence ID" value="CAG5072759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2EAU6"/>
    <dbReference type="OrthoDB" id="7697944at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071897">
        <property type="term" value="P:DNA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47027">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47027:SF20">
        <property type="entry name" value="REVERSE TRANSCRIPTASE-LIKE PROTEIN WITH RNA-DIRECTED DNA POLYMERASE DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5072759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="134" mass="14700" checksum="1B72518870017E37" modified="2022-05-25" version="1">MLLYADDSVILANTIFDLKRKLSVLNDYCSRNSFTVNIDKTKCVYFKRGGPRGRTRLLYGDNVVEWTDSYTYLGVPFTSSSLGLSAARMASQKAQIAAGAVISTLASIGAESWEGTLRIYDVIVASTLLYASHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2ECF9</accession>
    <name>A0A8J2ECF9_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS1556</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001116">
        <property type="protein sequence ID" value="CAG5075402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2ECF9"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5075402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="191" mass="21806" checksum="BB6860060F1D09DC" modified="2022-05-25" version="1">MSKRRNGESAEKMQFYAEKLKKYQKLLDEVKDLSDEKDSDVESHIGKGSDNDDLESLSSNGEVNSQTTSRELQETKVDVEEPPTQLSEKASLLLGVAKRQLKDQTFNFHPELAACWNEILDSGLDAKIKKSFEETYPNKGDCSLIAPELNPELLPFLHKTAKSRDKYLVSSQGSLWPRFSRTRKIYLCNFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2EN09</accession>
    <name>A0A8J2EN09_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similar to kra: Protein krasavietz (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS1225</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001116">
        <property type="protein sequence ID" value="CAG5075038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2EN09"/>
    <dbReference type="OrthoDB" id="1727522at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051245">
        <property type="entry name" value="eIF5-mimic_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057397">
        <property type="entry name" value="HEAT_5MP1_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14208">
        <property type="entry name" value="BASIC LEUCINE ZIPPER AND W2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14208:SF2">
        <property type="entry name" value="PROTEIN KRASAVIETZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25504">
        <property type="entry name" value="HEAT_5MP1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="5MP1/2-like HEAT" evidence="1">
        <location>
            <begin position="18"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF25504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5075038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="284" mass="32228" checksum="1C8FC9DAF41AA5D4" modified="2022-05-25" version="1">MSQKIEKPVLSGQRIKTRKRVLLGLEKADNDLDAVSKYLDTAGSKLDYRRYGEALFDILIAGGLLVPGGSVAQDGDKLCKTKACVFEQPMDMESLKNFEQVFIKLMRRYKYLEKMFEEEMKKVLVFIKGFTTHERIKLARMTALWISNGAVPPTVLGVLINEHLVKDNLALDFLLEVFVTWKNEKGLPSLMTALKRGGIEGRLMEFVPPNKRTEEYFRSVFESVGLTDIVKLHKNQASQEAKRDLQQLLVEDLADNRAIKDIVLDVKEMALKCAIPEHEVIGLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2GZR2</accession>
    <name>A0A8J2GZR2_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Carboxylesterase clade D member 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HICCMSTLAB_LOCUS979</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001114">
        <property type="protein sequence ID" value="CAG5074242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2GZR2"/>
    <dbReference type="OrthoDB" id="19653at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000155">
        <property type="entry name" value="Carboxylic ester hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43142">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43142:SF1">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0719">Serine esterase</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035158999" evidence="5">
        <location>
            <begin position="18"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="6">
        <location>
            <begin position="28"/>
            <end position="549"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAG5074242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="584" mass="66123" checksum="2D53657C4D7F99C3" modified="2022-05-25" version="1">MLKLSVILLCGLLYVDAAMSRNQTSSDPPEVTTPLGKVKGSLMETRLGKTIYAFRGIRYGEPPIGQLRFKQAEPVKSWEGTFDASKEGPSCGWLESKLQSEDCLRLNVYTTKLGDHSLKTPVIVFFHPGGFYGFSGQSYLFGPQYLLDEEVVLVTTNYRLGAIGFTATGDAEFPGNLGLKDQVQALRWVQQNIAAFNGDPECVTIVGYSAGSWSVALHMLSPMSRGLFHRAVAMSGSPTKGEQLQHQQLDLAKKQARLVGCPSESTRIMRECFEKVPADKMAATVRNMTDWGWDPIRFWSAVVEPDIPGLERFIVEQPVDSIRCGNFYSVPFMSGSTLDEFGGQALVPVVAARHGNNSVFDDLNANWDHIAPIAFQFQRNSSRSKRISDELRDFYFKNETIGLQNWQALAHLYGDAIVSFPIHRIVDLVSRYSDQPVYYYHFVYPGRYSWHVWSDTKKPFGVVHHDDLMYLFYMQRYFPYFNETAPEIPTVEHITAMWASFAKTGNPIPKDNPLFKDVTWEPFQPETGQYLEINSTLTMKFNLNAERMEAFERIFPLEEANFSLSSQNFLPFAGSWTPDDRPYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H2W3</accession>
    <name>A0A8J2H2W3_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS90</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030000584">
        <property type="protein sequence ID" value="CAG5071826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H2W3"/>
    <dbReference type="OrthoDB" id="7656790at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5071826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="135" mass="14974" checksum="929D65A0772F64AB" modified="2022-05-25" version="1">MGNASSGRATTTFFIVSVNSPVKLVFPKRSLSFTSYISMIMGGCSFPDCHNSSEKGFKMLRFSHLVEMRSKWTTACKISKPITENSHILIPSPGKLFDVFETDDDNDDHYSVKSKRHKSGVSGSIVANVIKKYSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H3R5</accession>
    <name>A0A8J2H3R5_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS1538</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001116">
        <property type="protein sequence ID" value="CAG5075384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H3R5"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5075384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="91" mass="10051" checksum="842A0CDDA6484A72" modified="2022-05-25" version="1">MPLLSSGDSTYGGASDDPLTETERNNRENRNSNREIDMDIDESSGNEDIVNESELQTDAEDSEDDRQSEEGETGADQENPERPPHRVGLAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H3T0</accession>
    <name>A0A8J2H3T0_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Trypsin-1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HICCMSTLAB_LOCUS2099</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001116">
        <property type="protein sequence ID" value="CAG5076118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H3T0"/>
    <dbReference type="OrthoDB" id="546450at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000006">
        <property type="entry name" value="Serine proteinase stubble"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033116">
        <property type="entry name" value="TRYPSIN_SER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24252">
        <property type="entry name" value="ACROSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24252:SF7">
        <property type="entry name" value="HYALIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00135">
        <property type="entry name" value="TRYPSIN_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 5" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0720">Serine protease</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035236095" evidence="6">
        <location>
            <begin position="17"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="7">
        <location>
            <begin position="61"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG5076118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="300" mass="33515" checksum="070E17DEA3E25AE2" modified="2022-05-25" version="1">MKKVIILLSLFALVNCYQKKNIVGDVVRNFFGIFGNKPPNATASTGPCYCSCGVKNEESRIVGGQTTQVNELPWMVRLSYLNKFYCGGTLINDRYVLTAAHCVKGFMWFMIKVTFGEHDRCDEKNKPDTRFVVRAITGDFSFLNFDNDIALLKLNDRVPLTNTIRPICLPIVKENDYVGTKAIAAGWGTLHEDGKPSCLLQEVEVPVMSLKDCRNTSYSPRMISDNMLCAGYPDGKKDSCQGDSGGPLIAERPDKKYEVIGVVSWGNGCARPGYPGVYTRLTRYLDWVLYNSRDGCFCQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H3X4</accession>
    <name>A0A8J2H3X4_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Olfactory receptor 126</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HICCMSTLAB_LOCUS1798</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Odorant receptor which mediates acceptance or avoidance behavior, depending on its substrates. The odorant receptor repertoire encodes a large collection of odor stimuli that vary widely in identity, intensity, and duration. May form a complex with Orco to form odorant-sensing units, providing sensitive and prolonged odorant signaling and calcium permeability.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Interacts with Orco. Complexes exist early in the endomembrane system in olfactory sensory neurons (OSNs), coupling these complexes to the conserved ciliary trafficking pathway.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the insect chemoreceptor superfamily. Heteromeric odorant receptor channel (TC 1.A.69) family. Or2a subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001116">
        <property type="protein sequence ID" value="CAG5075662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H3X4"/>
    <dbReference type="OrthoDB" id="6597368at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005549">
        <property type="term" value="F:odorant binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004984">
        <property type="term" value="F:olfactory receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004117">
        <property type="entry name" value="7tm6_olfct_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21137">
        <property type="entry name" value="ODORANT RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21137:SF37">
        <property type="entry name" value="ODORANT RECEPTOR 46A, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02949">
        <property type="entry name" value="7tm_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0552">Olfaction</keyword>
    <keyword evidence="7 13" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="8" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="31"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="62"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="126"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="171"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="265"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="294"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00037764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00037946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00038679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAG5075662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="388" mass="44900" checksum="B598B035A3C222AA" modified="2022-05-25" version="1" fragment="single">MEVLTDSFLVLKLFAGWVPLRWSLSLKEKIYNLYTLIIEMILVTFCISCIVDLFLTENIDDIVHTMSMAFTIMTVFAKLTLMTVKRNAILHIFQLLQSDTCIIKSDEEAHIQLGHDKRIKNVTMQYGGLACVAVIAISGASMIENVPTRTLPISGWFPYQHSNSTGYWFAYFHQIIALSYGGMIGLSFDTIAFGVMIQNSSQLRILKHRLENFTEIITKHRQHQNIKILHFSVRSLERKVLQKLINHHQVIIQYSRLSNDVFSPVIFLQYTLSSLILCMCVQSLTKLAFMGPEFVFLLVFLGCMLLQIYLYCWYGNEVMLESMDLSVSIYKMNWYFLTNECKKDLLIMKTRTLEPIKYTSGTLIELSLDSFTNLVKFSYSVYNLLHQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H549</accession>
    <name>A0A8J2H549_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS1146</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001116">
        <property type="protein sequence ID" value="CAG5074935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H549"/>
    <dbReference type="OrthoDB" id="7683472at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012464">
        <property type="entry name" value="DUF1676"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21879">
        <property type="entry name" value="FI03362P-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21879:SF8">
        <property type="entry name" value="OSIRIS 23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07898">
        <property type="entry name" value="DUF1676"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035170673" evidence="2">
        <location>
            <begin position="25"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="172"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5074935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="264" mass="29758" checksum="6FB867920D0437D6" modified="2022-05-25" version="1">MFAVFKFSLAIFVVINLLATQTTAEDFGGWTESLTRLLKICASNYNSFNNRINNNKENAKSDILESLKFCLQKRAVIAMDAFFSEEVIPLINGVDLMKFNDTNATDYNESFNTARANGKTWPEIVFGRFARLFKTHVLKIDIDRIVNPEAFVDESNEIVEGRRRHHRKRQNHLMPMLMMGVLVMGSVLIPMGFQFLAVLGGKALLLAKLALMLSSIQGLKKIATNGVNYGLYHAPVSDGWHERSSRLVDPLAQYDVPYAALARH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H591</accession>
    <name>A0A8J2H591_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to Slc16a12: Monocarboxylate transporter 12 (Rattus norvegicus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS1490</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001116">
        <property type="protein sequence ID" value="CAG5075336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H591"/>
    <dbReference type="OrthoDB" id="6499973at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008028">
        <property type="term" value="F:monocarboxylic acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17352">
        <property type="entry name" value="MFS_MCT_SLC16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000320">
        <property type="entry name" value="Monocarboxylate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF293">
        <property type="entry name" value="HERMES, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="25"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="48"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="91"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="117"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="153"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="184"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="479"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="504"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="539"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="567"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="261"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="315"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="281"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5075336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="607" mass="65737" checksum="0EE4D7F696D56175" modified="2022-05-25" version="1" fragment="single">TLLTNFFFITVDISPTGEWIPPDGGWGWLVLLAAVMVNVLIPGTIKSFGVLFVEFLSVFESGSAMAAWIPALCYFLYSSLGPLSSILSVKYSYRTVTLIGGTFAAVGMMLSFFADSIVFLCISYGVFLGIGAGLAFPPTVYIVTSYFLRLRGFANGLCISGSALGSIFLPPVLNYLLQEFGYRGAVLIMGGVLLHVWAAALLYEPVEKHMKFVPLPVEKLTDKQVAEEEEEEETEETDQLNHNENCKNSLLIIPTIKTEKPPAVNNTNNSLSPKPKAVPKSASSVALENYKNTPVQNRTRKISMPTNREITSQMHSTPALHAVPERSSSTVRRKSTLRSPSISSFNYISTPYHGSTLSALQPEYASNLTLNAISSTFRKSPEKTIKPANNANNSTDNAKTKFFDLSLLKDPIYLVILISNSTNAVSYTNFIILLPVYAISLGYDRNRAIALLSLNSAFDLIGRIGGSALSDTKIMPKHWYFVGGLLVSGVALTLMPTSTSYTMLASYCSIFGLASGIYVGVTAVIMADMLGTEKLTSSYGISLFVNGIIQLVGPPICGTIFEHIGSYGPIFSSLGIVLIAGASLWGCVPFIRRRQKAGNLKAQASKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H595</accession>
    <name>A0A8J2H595_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Peptidase S1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS74</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030000532">
        <property type="protein sequence ID" value="CAG5071603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H595"/>
    <dbReference type="OrthoDB" id="6656697at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24258:SF129">
        <property type="entry name" value="LP15124P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24258">
        <property type="entry name" value="SERINE PROTEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase S1" evidence="1">
        <location>
            <begin position="2"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5071603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="61" mass="6646" checksum="A19FBB4DC16C8792" modified="2022-05-25" version="1" fragment="single">MLKKVELPVVNHDTCQNYLRSTRLGKYYILHTSFMCAGGEAGKDTCKGDGGSPLVCPLVND</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H702</accession>
    <name>A0A8J2H702_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to BRAP: BRCA1-associated protein (Homo sapiens)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS3026</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001117">
        <property type="protein sequence ID" value="CAG5079494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H702"/>
    <dbReference type="OrthoDB" id="273556at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007265">
        <property type="term" value="P:Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011422">
        <property type="entry name" value="BRAP2/ETP1_RRM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24007">
        <property type="entry name" value="BRCA1-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24007:SF7">
        <property type="entry name" value="BRCA1-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07576">
        <property type="entry name" value="BRAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BRCA1-associated 2/ETP1 RRM" evidence="2">
        <location>
            <begin position="125"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="53"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5079494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="187" mass="20744" checksum="20A08E928DA71A60" modified="2022-05-25" version="1">MSTPTLVSLCVIRIEVVNTQLEESACEMATRKIRGRREPQGSVSLLSSLPIRSNKPNSTSKSNSEELPYPINVVSSNGTIEGTPAQSFSSTNQIDFFSGNRYVEVTQGILHLYKEDELTEMHHAADRSHTVCILSVPATMTCHDLLTFTAACHQDIQHFRILQDNNPNQYMALITMRSSANCSQSIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H7P3</accession>
    <name>A0A8J2H7P3_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to UBR7: Putative E3 ubiquitin-protein ligase UBR7 (Homo sapiens)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS3651</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5082783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H7P3"/>
    <dbReference type="OrthoDB" id="10262564at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15542">
        <property type="entry name" value="PHD_UBR7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040204">
        <property type="entry name" value="UBR7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13513">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE UBR7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13513:SF9">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE UBR7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="143"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="242"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5082783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="297" mass="33726" checksum="357B9FC840B5B4E9" modified="2022-05-25" version="1">MADTSKNVENCEEDNSVTMLDVLQEANQLEEDANAVLGASDDGSCTYNKCKAVENKENKYNQNFKGVYCTCSRPYPDPEDTSDDEMLQCVICEDWYHSKHLGSPEEEIPEDDSFEEVICKDCMSKHDFLRNYAAKYSSSKTKKNSVNNKEDVDVTSPPSETCTMPEKPSTEKTGACFWIEGWRSLLCVCENCKKLYKEQQVSFLLDPTDSVQAYEEAGKVGSSESQYEKGMKALASLGHVQQVNAIEEYNNMKERLKEYLQKFAENKKVVREEDIKEFFSGMASNKKSKVIVPSFCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2025-02-05" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H8A4</accession>
    <name>A0A8J2H8A4_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS4044</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5084209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10368570at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032062">
        <property type="entry name" value="DUF4803"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47890">
        <property type="entry name" value="LD24308P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47890:SF1">
        <property type="entry name" value="LD24308P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16061">
        <property type="entry name" value="DUF4803"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1456"/>
            <end position="1484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1460"/>
            <end position="1471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1472"/>
            <end position="1484"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5084209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="1555" mass="178520" checksum="64F1DEBD7D23A424" modified="2022-05-25" version="1">MSSSQTSVMSESGKEGTDYIQANTYITLLKNGFVNCDAPLDFNNKTSLINYLMSMSNRAINNYKLFETLPNKKNMEILNLIHRDMLEKLNELDQISSHSEYHKTNVSEWMAVMHFLGAYGFKEIGDKYTLYSTFSLETRLAHLHDSILQSIDTIKVIGSPKSFHSVENFCTIALRITNSFLDHIDENSITNLYSKTIDNISTEINSLTSIKRKIKPDYCGETISFQKALYEYYRQMIKIKIQQTIINFFYRVLNMRCNNIRVENLSLFGRKVPKSIRQMIQKTSKIMNNINYYIYNCDGPVDTQSNETSNLELKRIMETKIILEEHLSKTQLCDHNCDLEVIDQNINQTHCEEFRDCRHISTHTNSCKPGSGKSDLCDENQHSCGYCICTCMINSQNSTHITTAINFREQVSDIFNNKVVAGVKFSESNNMMHINILESKLHPGMNNLFYGVKIVSETIEYNEEAQNYHIVNENGTVTTLIPGVDYGHPETMFLDDVIAPYGHVITGAKFRIAGDIKEPPVTTGPIQLQIRVTPFDFRKNKLVNLGKTRWITANSANPREEMLLEEPDNPTKSLKNLPDSAPNQFIRFRRTDFRKDAGRSIVPFFDGQMIGRNEPPPLGGIGIYHRGCKGMISANKQLSIRNISSIFNYLKQIESTALNDYKFDSSLSDEKNEKLLDKINTDKVKVFTQLKSMSSEFDETYDESEWADIIAMIGINGFKLKPDYMVPYFFSVGNDIDNLLKKIDSSMVFFKPIGRMSLYNGSVSNFCTYTLPTLDTFFETLRHESLAKLYIKFIGRMVKTEMVSIFTEQIENQINLCGKLMSFNRALWSYYHIMMMGHIKYCVLMYYKWAMDVRCANEPIVYDIKWLDLATEQAQKMMNETKRALKNVNYYVHNCDPTFEELEYGDTEIELKRMIQAVLMDESGLSTTQSCGHRCNLELIGNTVNNTECQELRDCQYIDHDVEICPLEKKSRRYSWFRDSAGNVYGHNKTCENLKLLTSKSKRNDQELCGYCLCTCVTRPSKSVITSVQFTEQDYMIHIQTMEAQFSQSSQMGDDRWKPLENFDYDEATEQYYIINRNGTHIPLLLGVDYARPEIMDLDNVMAPRGYVVTGVRFRFAGDSLEKPKLKTGPIQLQIRVTPFDFIRGKLINLDKTHWIGPQSSIQRREMKLENPNRPTRCRKNNPDSISNQFIEFRASDLRKDAGQSTVPFFDRQIVSFYDTSPFGGLGIYHRGSKKCGGYLAFRAFDFELSKFLYKKLTNTQILCISNSLFKDAKYLYAEYEIINSECGFCLCTCVSKPSKTGNVIAAFSFREQVSDILNNKVITALQFIEKNNMIHIQVMESELMPSGETDLAPWKPLENFIYNEKTEMYYVVHDQSIVTLVPGVDYGHPEIMNLDDVIAPPGHLITGVKWGFAGDSLEKPQMKTGPMQMQVRVTPFDFDQGKLIDLNKTHWITPNSENPRTEMVLERSDNPSEASNNPPDSKTNQFIKFRTTDWCKDFGARTVPFFNGQTVRFLPMTALGGVGIFHKGITGYGGYLALRVFDLNFSKFMNSELI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H8P0</accession>
    <name>A0A8J2H8P0_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Similar to lysmd4: LysM and putative peptidoglycan-binding domain-containing protein 4 (Danio rerio)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HICCMSTLAB_LOCUS4339</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5085310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H8P0"/>
    <dbReference type="OrthoDB" id="538216at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="entry name" value="LysM domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045030">
        <property type="entry name" value="LYSM1-4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20932:SF13">
        <property type="entry name" value="LD36653P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20932">
        <property type="entry name" value="LYSM AND PUTATIVE PEPTIDOGLYCAN-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01476">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00257">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54106">
        <property type="entry name" value="LysM domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51782">
        <property type="entry name" value="LYSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="213"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="3">
        <location>
            <begin position="56"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG5085310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="264" mass="29959" checksum="0A37EED7A3A512EB" modified="2022-05-25" version="1">MKKLNDDKRNIPYQRGNQRDKSPHYVFLYSDDEVDDEEVPLQVRKHKSTPRKVEVIVVNLKPEDTLQALALRYHCTISELKRINSIHKENEIFARRTLKVPIQPFSILTETEKLIDIEDEPAALHPSTSNAQLIINLPKSDSTLKGFVSKDESDINTLILNSVCEPVNKFTGPDLDIDDECNELLPGGSRDSTPEAQVINSLRCSGADWGLSFLHLLLLILLLAIVLPIIYIFYIAEHPQHIIVIDSNFTDSNLIENSSVRQLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H921</accession>
    <name>A0A8J2H921_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ANK repeat and PH domain-containing protein 2 (Homo sapiens)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HICCMSTLAB_LOCUS3556</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5082418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H921"/>
    <dbReference type="OrthoDB" id="29546at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005547">
        <property type="term" value="F:phosphatidylinositol-3,4,5-trisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048699">
        <property type="term" value="P:generation of neurons"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17113">
        <property type="entry name" value="RA_ARAPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052227">
        <property type="entry name" value="Arf-Rho-GAP_ANK-PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000159">
        <property type="entry name" value="RA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45899">
        <property type="entry name" value="RHO GTPASE ACTIVATING PROTEIN AT 15B, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45899:SF2">
        <property type="entry name" value="RHO GTPASE ACTIVATING PROTEIN AT 15B, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50200">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="3">
        <location>
            <begin position="680"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="domain" description="Rho-GAP" evidence="5">
        <location>
            <begin position="784"/>
            <end position="971"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-associating" evidence="4">
        <location>
            <begin position="1001"/>
            <end position="1095"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="378"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="487"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="33"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="51"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="77"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="392"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAG5082418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="1229" mass="138144" checksum="96B6303B343987FB" modified="2022-05-25" version="1">MEVKPVPKPRSLIPERPVPAPRNLCPPKTVNQSASTRSLSPSESSSQSEMSDDRRSTESRSSSEKNLFKNLGTSSRQLKDELSEKMTVKGKAMISSTRNASIRLEKSVKNLLTRRLTSSQDQDESKKNEDDVDRCVSMPAGCDDIFKSISFYSPLTSNLKSVKNEQDLTETRYSPPPPVYPPPPLPDESIYDELQSVTSGSRCGTMSSSLSVSDRLLDFPDTASLLKFARNRSDSESNQSLNFSDANYSQKEDIIKRLSRSDSWTFYDSAFSEDRNDKNETDSTLDTIASNVEEEEPIRERVSDSCNSAMSVRNSLYENWSLSKTGDSETDSKTRNQTHSKSLLFEFDPFAKTEENTYGNYENNDMMLLEALLATSESPTSAGSVTDLRECDGEEDTGEEDVGVEDSGSPNQAMISSPPPPPRRFDSLPKNEYDEVELVEAPEKVVGKNPALLPKLVHLARRKQPAVPPRKSSVKVLDESVLEEAANLSLSKPEEDNSVPKPAEERKKTMMQKLKKLRHDSTAHVRPNVMNFMKNSKLLRREQHEVKKVAVMKMERPKLESQVIPVCHRGIVYRSGVGMERAKDLVQRAAVLSDQKISFYVDKSMVTLKEVIHLDAVQSVHLLQDVKTVDGETVHCIAVSCQGRPSVHVFYAKGITERRIWAQRILEALTPVFPAKYSAELTRAGWAYLKEGVTGSWFSAWVLLQQRTLIYTRSLDIVEFEQLDLRKARCILIREQEGPIEGAGNIPIVVIDAGHGALHLAAPGTREAPAWRHALHQAATSCGAGLDEQQLTQDDVPVILDKCINFIYAHGIMSEGIYRKGGSSSAVVRLLEAFRRDAWATQIIRSSYSEHDVATVLRRFLRDLPEPIIPPCVHNELCRASDIEDTDERSNKYRSILMPVLNEVSKKTLRRILAHLHCLSQQSSRNLMTVENISAVWGPTLMHAGSKSAEDWNRAETSVVGDLIRFYPKLYQLSADDLAKEAKILEVLERHVANNGLRGAPSGDLKIWIYLFTKDGECVNVTIGPQKSAADVCRELSEKAQVPAHELCLQECTLGGALERPLHHAEKVLEAVARWGYWDPEDRKDNILILKKDRLYRDIVPRIKPPMTISGELKFADTKSKHFKSYLFEFSQAKLCCYKDKACAIKIHEWKIEDIIWYLGHEPKRNPQSGWSITFLLKNKKPTRCKDSPFFGNVLAGVSVVDQYRWLAAMLFGEHQLNLLPSAINLMDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H927</accession>
    <name>A0A8J2H927_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS3736</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MTFR1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5083119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H927"/>
    <dbReference type="OrthoDB" id="2133332at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007972">
        <property type="entry name" value="Mtfr1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05308">
        <property type="entry name" value="Mito_fiss_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="72"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5083119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="92" mass="10440" checksum="DDAF6D15C43153B5" modified="2022-05-25" version="1">MLGISPSTKKNPNVNSKQRMGEAPKYYGKRRSLVRRIGSFLPLKPPPKIYVRQQTIWKQTRLTRTNKFRLRSKTPSIGAGTPGIEVTSIENS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H9E3</accession>
    <name>A0A8J2H9E3_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Similar to oca8: Probable cytochrome b5 2 (Schizosaccharomyces pombe (Strain 972 / ATCC 24843))</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HICCMSTLAB_LOCUS4352</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the cytochrome b5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5085350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H9E3"/>
    <dbReference type="OrthoDB" id="260519at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050668">
        <property type="entry name" value="Cytochrome_b5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19359">
        <property type="entry name" value="CYTOCHROME B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19359:SF41">
        <property type="entry name" value="GEO08203P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0349">Heme</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="5">
        <location>
            <begin position="89"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAG5085350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="159" mass="17793" checksum="859F927A5C57CCCA" modified="2022-05-25" version="1">MLSSITRAVSLDRLSGEIRMFGKLSKNPSNNNLDMDYLNLGFLALELRETVSKTLSSIKNELKQSLSEKSAVENKNNNKNVSNKSESNLKTITLEELSWHDTIDDCWIAIYDYVYDCTEFMIKHPGGGDVLCEYAGRDGTIAFISTGHSESAVNLLDKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H9M9</accession>
    <name>A0A8J2H9M9_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Small integral membrane protein 8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HICCMSTLAB_LOCUS5092</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SMIM8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5089073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H9M9"/>
    <dbReference type="OrthoDB" id="1880105at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026686">
        <property type="entry name" value="UPF0708"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14274">
        <property type="entry name" value="SMALL INTEGRAL MEMBRANE PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14274:SF1">
        <property type="entry name" value="SMALL INTEGRAL MEMBRANE PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14937">
        <property type="entry name" value="DUF4500"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="24"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG5089073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="74" mass="8382" checksum="5BC43D602AE716A3" modified="2022-05-25" version="1">MFYKKDKDTQKVAAAPGDGLRSNMVIMGLGLTAMIGCSGYIWYMRSQYEDMGYYTAVESDGKETFKKKESKWSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H9N6</accession>
    <name>A0A8J2H9N6_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Similar to armh3: Armadillo-like helical domain-containing protein 3 (Xenopus laevis)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HICCMSTLAB_LOCUS5103</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5089099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H9N6"/>
    <dbReference type="OrthoDB" id="2012278at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039868">
        <property type="entry name" value="ARMD3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013636">
        <property type="entry name" value="ARMH3_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13608">
        <property type="entry name" value="ARMADILLO-LIKE HELICAL DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13608:SF3">
        <property type="entry name" value="ARMADILLO-LIKE HELICAL DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08427">
        <property type="entry name" value="ARMH3_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01158">
        <property type="entry name" value="DUF1741"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Armadillo-like helical" evidence="5">
        <location>
            <begin position="417"/>
            <end position="616"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAG5089099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="634" mass="71947" checksum="40B53D7F0A793BC2" modified="2022-05-25" version="1">MAMRKRSGSGSKRQHKGKLIPIYESLFKGEDLTSGHPNFWNEVFLIKPIVPHIENEILKMSAEQLSTCKNNLNALVCHSIDTLIDEHPFRVVYALQTLAAVIQSIYKKASQNECDFNLVDVLIGLKDAEERMTTLMQHCNTFLLGEYPDSLKALCLKLLLIIVTGTDNLSQNSLLEYVMVNGVFESLIQLLRETTLRNRHGHDAVLLLTLLVNYRKYESTNSYIVKLSILDDELALNGYSQVISGSLMEFCRLFVQQKAEVQASWLSSLTSMVGSMFVGEEEAKTQQVRANNALLLALYEATHLNRNFVTTLAFTKSDTSAPPSPNNTLGPNAVAPGSQPPDVIAQPFNLLAIFLQYCSIVMQAIKTEAILNNVKLCFLILSCIAEDQYANNLMHDANLAFRVQLHRMPMYHRKIQDKVAPTQPLAATLLDLLVEFITSHMMKKFPLELYHQCIGVLQRLLCYQKRCGVRLGYQWKELWTALFNLLKFLTTHEAHLVKKMNIFPLAIQIVNILNLFITYGDTFLSLPSSYDELFYEIIRMRLIFTNLNAMAWLASESLSTPTEQQILAIIIQNYDTLALKLQDNLDQYERYSEKPNHTTFFEEMVTGIIIDTRASINLNALDTQAILQELSNIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H9X3</accession>
    <name>A0A8J2H9X3_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">alpha-1,2-Mannosidase</fullName>
            <ecNumber evidence="7">3.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HICCMSTLAB_LOCUS4362</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the glycosyl hydrolase 47 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.-" evidence="7"/>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5085391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H9X3"/>
    <dbReference type="OrthoDB" id="8118055at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044322">
        <property type="term" value="C:endoplasmic reticulum quality control compartment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004571">
        <property type="term" value="F:mannosyl-oligosaccharide 1,2-alpha-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904380">
        <property type="term" value="P:endoplasmic reticulum mannose trimming"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044674">
        <property type="entry name" value="EDEM1/2/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001382">
        <property type="entry name" value="Glyco_hydro_47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036026">
        <property type="entry name" value="Seven-hairpin_glycosidases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45679">
        <property type="entry name" value="ER DEGRADATION-ENHANCING ALPHA-MANNOSIDASE-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45679:SF2">
        <property type="entry name" value="ER DEGRADATION-ENHANCING ALPHA-MANNOSIDASE-LIKE PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01532">
        <property type="entry name" value="Glyco_hydro_47"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00747">
        <property type="entry name" value="GLYHDRLASE47"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48225">
        <property type="entry name" value="Seven-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035144250" description="alpha-1,2-Mannosidase" evidence="9">
        <location>
            <begin position="25"/>
            <end position="1051"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="961"/>
            <end position="1051"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="964"/>
            <end position="985"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="990"/>
            <end position="1000"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1002"/>
            <end position="1034"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="5">
        <location>
            <position position="132"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="277"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="5">
        <location>
            <position position="322"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="340"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="426"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAG5085391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="1051" mass="118585" checksum="322D28A322DCE167" modified="2022-05-25" version="1">MAAIWFGLLIIIVNIVLLIAYVQTDDLEYMRPEERESLKEEARDMFYHAYNAYMSNAYPADELMPLSCKGRYRGSEPDRGDIDSTLGNFSLTLVDTLDTLVVLGDLEEFENAVKLVVRDVSFDTDVIVSLFETNIRMLGGLLSGHILSEYLQVRADIMPWYRGELLNMAKDLGYRFLPAFNTTTGIPYGRINLRHGMKNVPAEMCRETCTACAGSMILEMAALSRLTGEGIFEEKAQKAMDALWKMRHRGTDLMGSVLNVHSGDWVRRDSGVGAGIDSYYEYCLKAYILLGDEKYLGRFNKHYSAVMKYVSQVLQRHNFIPEAFTTDFQVHWGHHPLRPEFLESTYYLYRATGDHYYLAVGRKVLKSLQTYARVPCGYAAVSDVRTNKHDDTMESFVLSETFKYLYLLFAESSDLVLDIDEFIFTTEGHLLPLTLASLRTNVSSDVDIDTVEFDELDRTCPNSLHLFPASVRKPLRNMVEDVCPRRSMRRRISAAQFQANNLDHLKILSNMGITVLTMADGRMQLLHTFSNAKTMEDAEEGLMFMQEMVELNRRQSQESDKQRLALTIKRKDVNKDLTLLGGPAQFGLQLSGSVKITGKPVLTEPKEACSELTNVDMIKGNIAVIFRGNSGAIGGIVLDTVIGSTIESSPMFAMSGDGITRDNIKIPFAFLFNIEANELVRAISESNGAITVTMGNYANDGVEKSDSDNYLSMFERLKSSVKEFLTRPSTTENTPNTISAPALDNKEEMIIDKDHLRAIIPRESAVKNKQNRDLVLFAKLMFNKNSPLVSATTPSSTTELSAFEKGWKVVKQFLINQIYVNTKFPPYQVISVGRIETYYDWIQKERNPKSPIKSEELNTFELVTWFIDELSDTLPNFDKANSFGSISKVSKSLIQKLSSSISKNDIINIDTNEDIEGYNEDNTKDDKKLGNIMETYKIYDNLMENIQDVLKNLKTEFKSKGLDDNNSNVGNNNNNNNNNNNNNDNLIVPNYSNQTNQNSVIAEEKKTGDEINIKDNVIDNENKGDASSEDRIDSENNAINKDNATKSNDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HAD3</accession>
    <name>A0A8J2HAD3_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Similar to ALKBH4: Alpha-ketoglutarate-dependent dioxygenase alkB homolog 4 (Homo sapiens)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HICCMSTLAB_LOCUS5045</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the iron/ascorbate-dependent oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5088969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HAD3"/>
    <dbReference type="OrthoDB" id="442860at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032451">
        <property type="term" value="F:demethylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070988">
        <property type="term" value="P:demethylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.590">
        <property type="entry name" value="Alpha-ketoglutarate-dependent dioxygenase AlkB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037151">
        <property type="entry name" value="AlkB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032857">
        <property type="entry name" value="ALKBH4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12463:SF0">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT DIOXYGENASE ALKB HOMOLOG 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12463">
        <property type="entry name" value="OXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="3">
        <location>
            <begin position="142"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG5088969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="285" mass="32819" checksum="5452A9C3AC7EAE43" modified="2022-05-25" version="1">MRYTHVYNFKINIYFLYGLVKYCLKKIIIMETVRACGCKGIRTCLICEHEYNIIKPNTYKELQKLPSYQNFLDERETKTLIQDLDSLPWDISQSGRRKQNYGPKCNFKKRKLCLGIFNGFPINTEFVQKKLSQVPLLQGFRTIEQCSLEYTPERGASIDPHIDDCWIWGERIVTVNVIGDSVLTMTRYQGSNTRYNLDCVSTYPPVVPQSDCSEDDLEKAPEDVVIRLPMPARSLMVLYGDARYNWDHAVLREDVTSRRLSAYLTGSACKSITGDATKESTFPKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HB32</accession>
    <name>A0A8J2HB32_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Similar to Srp19: Signal recognition particle 19 kDa protein (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HICCMSTLAB_LOCUS4919</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER). Binds directly to 7SL RNA. Mediates binding of SRP54 to the SRP complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SRP19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5088638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HB32"/>
    <dbReference type="OrthoDB" id="2190947at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005786">
        <property type="term" value="C:signal recognition particle, endoplasmic reticulum targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008312">
        <property type="term" value="F:7S RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006617">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.56.30:FF:000002">
        <property type="entry name" value="Signal recognition particle 19kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.56.30">
        <property type="entry name" value="Signal recognition particle, SRP19-like subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002778">
        <property type="entry name" value="Signal_recog_particle_SRP19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036521">
        <property type="entry name" value="SRP19-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17453">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE 19 KD PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17453:SF0">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE 19 KDA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01922">
        <property type="entry name" value="SRP19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69695">
        <property type="entry name" value="SRP19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6" id="KW-0733">Signal recognition particle</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="88"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="112"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="123"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00045518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAG5088638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="144" mass="16220" checksum="F73F4ECE928FF7CF" modified="2022-05-25" version="1">MAVAFSESKNHSDRERWVCIYPLYINSKKSRAEGRKLPKSKCVENPTHQEIRDVLLAAGLKVGVENKLHPKERSKELLYRGRIRVQLKNDDGTPVNPDYPTRDSLMGYVGTSIPNLKTRQGKQSSSEPQQSSSTAKKGKGKGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HB46</accession>
    <name>A0A8J2HB46_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ubiquitin carboxyl-terminal hydrolase MINDY</fullName>
            <ecNumber evidence="8">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HICCMSTLAB_LOCUS6236</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="2 8">Hydrolase that can remove 'Lys-48'-linked conjugated ubiquitin from proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the MINDY deubiquitinase family. FAM188 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="8"/>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5092578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HB46"/>
    <dbReference type="OrthoDB" id="9981542at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990380">
        <property type="term" value="F:K48-linked deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071108">
        <property type="term" value="P:protein K48-linked deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025257">
        <property type="entry name" value="MINDY-3/4_CD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039785">
        <property type="entry name" value="MINY3/4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12473:SF17">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE MINDY-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12473">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE MINDY-4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13898">
        <property type="entry name" value="MINDY-3_4_CD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01174">
        <property type="entry name" value="DUF4205"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 8" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="5 8" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="EF-hand" evidence="10">
        <location>
            <begin position="307"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="112"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="116"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="135"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU367088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAG5092578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="448" mass="50112" checksum="04A0F483A0A571E7" modified="2022-05-25" version="1">MADPSSVNEAIVQIKTLLWGNSVKEEVFNRWAQGFIFSEDEPTALVQLEGGPCAVLAPVQAFIIKDLLLQGAPNTWRDITSDKQDALLVKAALEIISQAADDPPYYSLVHIVHGDDGDEDDNDGDGDGDGDGDGDGDREREEIEPHERDSEYFHSRLRIVETRNLDDVEKWLTSRIYMFKEQFGVLLLLYTVVCTKGLEGMTNEMSDPTEPAIDSTYGYGSQSLINLMLTGRAVGHVWDHDQNVGGLELRGIDKQNAVGFLAFLEHLRFCEVGTFLKSPSHPVWVLGSETHLTVLFSTDRRLVSPETPAEHARRIFKKFDPEGNNFIPSNLLGDVLAELGLCSDKEYIDIIRKKLDSESLGIILLAAFMDEYYPEEIQTCPDTFPLLHYNGLLRSNPDNRIIYHTGDAVLLECTVKCILDSNPMLTVLQTKWPSIEVQWNGNITPSLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HBB0</accession>
    <name>A0A8J2HBB0_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Odorant receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HICCMSTLAB_LOCUS6356</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Cell membrane</location>
            <topology evidence="1 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the insect chemoreceptor superfamily. Heteromeric odorant receptor channel (TC 1.A.69) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5092759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HBB0"/>
    <dbReference type="OrthoDB" id="8185860at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005549">
        <property type="term" value="F:odorant binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004984">
        <property type="term" value="F:olfactory receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004117">
        <property type="entry name" value="7tm6_olfct_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21137">
        <property type="entry name" value="ODORANT RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21137:SF35">
        <property type="entry name" value="ODORANT RECEPTOR 19A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02949">
        <property type="entry name" value="7tm_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 10" id="KW-0552">Olfaction</keyword>
    <keyword evidence="8 10 11" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="9 10" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="63"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="125"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="186"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="260"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="302"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU351113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAG5092759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="400" mass="46240" checksum="FACD4332C668F5C8" modified="2022-05-25" version="1">MTSSTHIDNYIMINRKILKLVGLYPVEVPRYIFCISCLLLIIIPEVFRVFSNQQDLDVILETSSVLSTILLAVLKSIIWMTFRRQDTTILINFLFKDYWNIVVTSCSSNDFQYVDKNAKMAKRVTLGYIILIVNALLVFYFLPLRHRILKAISKNDEQLSTLNTSLNFPFIAAYPQFCYESPFFEIVYLSQMVATSMCGIVILAMDTLIATAIFHSCGHFSVLCAKMKHINFENNHSTNHLMEVIKHHQLAIRFSNHLEYAFNPLMLFQVIASSVIICLVGFQVNTVSILFNTLKYDHKDKLVQYIAYLMMALFQLLIFCWPGDKLINDSLKTNEAVYSSNWYNYPFPEAIKTELILIMLRSQRPSYLSAGKFQFMSLENFSTILSTSLSYFMLLRSLDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HBK3</accession>
    <name>A0A8J2HBK3_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS5998</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5092248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HBK3"/>
    <dbReference type="OrthoDB" id="6369020at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="41"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="79"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="117"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="157"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="245"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="202"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="216"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5092248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="744" mass="84391" checksum="CEF855C7D802EB89" modified="2022-05-25" version="1">MRSEVGEWLATCVGSPICILLLSWSLLIYQNQPSSLKRRIDVLTVAIITQSLAHQLGLLLYAILTLIRPVNHFGEICSSLVWLLNSSSILQQLTLTSIAIFAAIFTKEDSSLTKNHLKYHLVSLTVISACIGFTGILNFESETCVFLAQEVSVKYGLFVNALKILLLFGTICGLCITIFKDACQSPKSELLQSVSDLSDTSSKNSGFDHQHHWDPSNGSFTSGSTNSRACLRKRKPRVDESGSKCTVFSILFVCYVFDHLPVLVISIRPELLNGFCTPQNIAIWLPLIKDTLLPVFLAIFDKMFCRYVAKVYTKQDNMRKLAHCGVDGKFRHFEQDAEYKLQLNLNHGLKFPLTNGSLYGRLHNHQNRARTGTITMGIQHYPRAQSLTDDTYGSLPAELTSFTSSTFEPRQHKDSKTNSIDTQSTQRLIKMNENFEFGTKRKIGSTDVFGQNMENLVQLEDPKRKQFARSLDEIREEVPKKDKDLKIQTRKDEQEFTRNLVRRNQSFDQSKYLRVGLDSRTYDIKDLIRKDRQMDLMRKDYEEDGFDSSDDGSCDFDNENFDDTLSSCKSRSRSCCSVTTVANDDFEFFQRKGTKTEIFSPKKLPDKINMRSFTPKIIDDTWIIENTASINKVNPLANNNNNKHNLNISNSNNKNSSNKKSVKLIVNTKPTIQSYHLKKISPGYSMNDLDKLFPEEKSQEKLGNASLKGTLKRSEIHHDSVSDATLRHIGGSAPDFKKIFLECV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HCF4</accession>
    <name>A0A8J2HCF4_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Aminopeptidase</fullName>
            <ecNumber evidence="17">3.4.11.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">HICCMSTLAB_LOCUS4890</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="15 17">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="15 17">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 17">Belongs to the peptidase M1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.-" evidence="17"/>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5088549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HCF4"/>
    <dbReference type="OrthoDB" id="510539at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042277">
        <property type="term" value="F:peptide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043171">
        <property type="term" value="P:peptide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09601">
        <property type="entry name" value="M1_APN-Q_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1730:FF:000013">
        <property type="entry name" value="Aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1910:FF:000008">
        <property type="entry name" value="Aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.50.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="entry name" value="Neutral Protease Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1730">
        <property type="entry name" value="tricorn interacting facor f3 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045357">
        <property type="entry name" value="Aminopeptidase_N-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042097">
        <property type="entry name" value="Aminopeptidase_N-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024571">
        <property type="entry name" value="ERAP1-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034016">
        <property type="entry name" value="M1_APN-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001930">
        <property type="entry name" value="Peptidase_M1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050344">
        <property type="entry name" value="Peptidase_M1_aminopeptidases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014782">
        <property type="entry name" value="Peptidase_M1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11533">
        <property type="entry name" value="PROTEASE M1 ZINC METALLOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11533:SF294">
        <property type="entry name" value="THYROTROPIN-RELEASING HORMONE-DEGRADING ECTOENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11838">
        <property type="entry name" value="ERAP1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01433">
        <property type="entry name" value="Peptidase_M1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17900">
        <property type="entry name" value="Peptidase_M1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00756">
        <property type="entry name" value="ALADIPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63737">
        <property type="entry name" value="Leukotriene A4 hydrolase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="17 21" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="8 17" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="11 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 15 17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 17" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="5 17" id="KW-0645">Protease</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="9 15 17" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="domain" description="Aminopeptidase N-like N-terminal" evidence="20">
        <location>
            <begin position="44"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M1 membrane alanine aminopeptidase" evidence="18">
        <location>
            <begin position="270"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="domain" description="ERAP1-like C-terminal" evidence="19">
        <location>
            <begin position="566"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="14">
        <location>
            <position position="340"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="339"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="343"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="362"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="16">
        <location>
            <position position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR634016-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR634016-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR634016-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU364040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF01433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF11838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF17900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="CAG5088549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="899" mass="105820" checksum="A29F2DF8632724C3" modified="2022-05-25" version="1">MITPNLFTSLFIFIKIILYGIFILSHTTISSASEQNRLPENFIPVHYTINIIPYIEENNFTFDGESLIVIEAKIESNSIILHAKNLQIKENITLKSADKIYESNNYTIDTKNDFLSIVFNEKIEQGNYTLHLKYCGVINDKLQGFYRSTYTDTFGKKQWLMSTYFEPNNARQAFPCWDEPAFKATFKISIKHNRRFTALSNTRFNSIRSTNDNSNHVWTQFEKTSPMSSYLIAFIVGDLDYLAYSENETFRVWTRKNAASRGEMLLSSGFKALKSLENFFGMSYQDHGFKKIDLVVIPEMTSIGMENWGIIFLKEDEFFSTENVESKQIGKNDFMDLTHELSHQWFGNLVTHKWWKYLWLTEGLPSYFSHFINDQIEKSWRVMDKFVLDRREDLFKYDSAYEVPVINADDKTENLWGYHRFYMNYYKSAVIIRMIKYVLGEENFRNGIRNYLNNNKFGVVTSDNFFNELTKVSGNMNVTLDKALNNWLNTPGYPMITINRNYTSNKATITQSRFLRNPNLNSTDRYWISLNWATQDNMDFNDTVITHWFDPDSISLEISAPESDKWLISNKQQFGYYRVNYDEKNWQLIASYLNSENYYKIHYLNRAQLIDDAFVLAEEGHVSYSIVLELIEYLRYETDSLPWATFFNNLLQLHGSSLPHSSYYESYKKIISTLLKNIEKNLFVIKTDENMIEMVLKKSIIKWACLFGSNLCKNYTLSIISKWLENSEENSLPVDLKLEILCGGMRYVDENTWNAVLMKYLENRDKDILQALCCTSNTTFLNKILFLAINNTFSELDMWDFFLAITSESSGLETTLNFINDYRTKIEKSDSRYEFLHDGIIFIRYNVKNSNQFSKWGELLKNVIGEKEATNYLVEIRSEVDDYNLKLNSMKNYFERRIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HCI8</accession>
    <name>A0A8J2HCI8_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS6711</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5093270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HCI8"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5093270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="195" mass="22366" checksum="AF511A9F9EB4C35B" modified="2022-05-25" version="1">MENFFDLDDMLIPVVADVDSDAETEVDDDLPGPVGDIESDDSGYDNDVEARFDGPATFRNWFGLHSRIAEANPNRRIGRIYSLYVDEELCVERFRHAATLPAGRHLLDLEFVPQIRQEGFLFMDPLLVLLGDLDSREAVWIFNYLPWQHREFRGRSLLRGLIGLGSRLRASIRTAPPRIVAVLEWFMMALEIDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HCM1</accession>
    <name>A0A8J2HCM1_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS4925</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5088650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HCM1"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5088650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="127" mass="14518" checksum="BDC81E1BC0940239" modified="2022-05-25" version="1">MTNDQGFLFLRAGLLKYYLEKFWIGTRFISWAEQNNIHLNIENIHWCTPDSNPVQCFGKQGPDPIGYCAPLEHWIDLNPRSFIPALDIITSVFFMNILRTDTSGRPIIRTVSIIGLVIAPKVSRQPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HDV0</accession>
    <name>A0A8J2HDV0_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11 15">Ubiquitin carboxyl-terminal hydrolase</fullName>
            <ecNumber evidence="11 15">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">HICCMSTLAB_LOCUS6399</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 11 15">Belongs to the peptidase C19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="11 15"/>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5092845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HDV0"/>
    <dbReference type="OrthoDB" id="361536at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02658">
        <property type="entry name" value="Peptidase_C19B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14294">
        <property type="entry name" value="UBA1_UBP5_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14386">
        <property type="entry name" value="UBA2_UBP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.10:FF:000167">
        <property type="entry name" value="Ubiquitin carboxyl-terminal hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000026">
        <property type="entry name" value="Ubiquitin carboxyl-terminal hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016652">
        <property type="entry name" value="Ubiquitinyl_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041432">
        <property type="entry name" value="UBP13_Znf-UBP_var"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001607">
        <property type="entry name" value="Znf_UBP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF664">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00627">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02148">
        <property type="entry name" value="zf-UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17807">
        <property type="entry name" value="zf-UBP_var"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016308">
        <property type="entry name" value="UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00165">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00290">
        <property type="entry name" value="ZnF_UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50030">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50271">
        <property type="entry name" value="ZF_UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 11 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 11 15" id="KW-0645">Protease</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="9 11 15" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="7 11 15" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="10 11 13" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 14" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="UBP-type" evidence="18">
        <location>
            <begin position="168"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="domain" description="USP" evidence="17">
        <location>
            <begin position="320"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="domain" description="UBA" evidence="16">
        <location>
            <begin position="614"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="domain" description="UBA" evidence="16">
        <location>
            <begin position="680"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="12">
        <location>
            <position position="329"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="12">
        <location>
            <position position="765"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="192"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="195"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="212"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="225"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR016308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR016308-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR016308-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU366025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="CAG5092845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="805" mass="90424" checksum="640C52E9D1DB4974" modified="2022-05-25" version="1">MESTMMLSMYSDVVKIAGPHDKIYKDECVYSFDTPESPSGLYVSLTSFHGLGRDYVERYSNKTGHRVYLNIKRLKKVSSEQAADGPAKKITRLAIGEPGGFNPNEKKYVFDDHYEIVILPDFKTFPYPSDLIPEKMNLSITSILNAESATKAAEREALAGTWDGEAKIISKHAENLLQLDNGRKIPPNGWKCDKCDLNQNLWLNLTDGSILCGRKFYDGSGGNNHAVQHYQETSYPLAVKLGTITKEGKGDVYSYDEDDMVEDPHLIEHLAHWGINITQLEKTEKSMVELELDLNQKFGEWVALQEAASKLTPIYGPGYTGLVNLGNSCYLNSVMQMIFMIPDFVDRFVNSAIEIFDNNTSDPANDFNVQMAKLGSGLLSGKYSIAPKSEDQNDAQQGIEPRMFKSLIGRGHSGFSSNRQQDAQEYLLHLLSILQRHSVQRANPANCFKFKVEERYECSSSGNVQYSYRPEYLLPLPIPMGAATNKEEVAAHERAKKEAEAAGRKLDSSVTVRPHIKFSSCLEAFAGVESIEQFYSTAINGKTIAKKITRLATFPDYLLIHLKKFTVNEDWTLAKLDVAVEMPDILDLTSLRGCGLQPNEKVLPEAAAEIPMPVYDQTILSQLIDMGFPPEACKRALYFTENQGLEVASNWLLEHMMDSDFADKFVPPGIEITLSKAPFVPSEAGLEYLLSLGFAEDRAVKALKETDNNIERAVDWIISHQDELDTHGVMEEEIRPAQVEYRDGDSHYKLVGFISHMGTSTMVGHYVCHLLKDNRWVIFNDEKVALSENPPKELGYIYMYQRLNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HDZ0</accession>
    <name>A0A8J2HDZ0_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Similar to GBX1: Homeobox protein GBX-1 (Homo sapiens)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HICCMSTLAB_LOCUS7542</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5095104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HDZ0"/>
    <dbReference type="OrthoDB" id="6159439at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020479">
        <property type="entry name" value="HD_metazoa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050394">
        <property type="entry name" value="Homeobox_NK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24340:SF109">
        <property type="entry name" value="BARH LIKE HOMEOBOX 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24340">
        <property type="entry name" value="HOMEOBOX PROTEIN NKX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00024">
        <property type="entry name" value="HOMEOBOX"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 5 6" id="KW-0371">Homeobox</keyword>
    <keyword evidence="4 5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="8">
        <location>
            <begin position="82"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="5">
        <location>
            <begin position="84"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="20"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="176"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="20"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="62"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="186"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAG5095104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="224" mass="24684" checksum="A9D8B53785BB321C" modified="2022-05-25" version="1">MQEHKSFLIRDLLGDVLAERVQDDSEDDSALHSDSEDTIDPGSSPCTRLSSPNPLLSPSPDPQVNSIKSCGGSTSGATQSGRKPRRRRTAFTHAQLAYLERKFRCQKYLSVADRSDVADALSLSETQVKTWYQNRRTKWKRQNQLRLEQLRHQATVEKELLVRGVGLHHGSIDAYCPPYSQTGNSPHPPPPPPPPAPSSASTAAFLSTAAALFRNVTYVHGCPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HEV2</accession>
    <name>A0A8J2HEV2_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Similar to RXFP2: Relaxin receptor 2 (Homo sapiens)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">HICCMSTLAB_LOCUS7067</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5093741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HEV2"/>
    <dbReference type="OrthoDB" id="6022531at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008528">
        <property type="term" value="F:G protein-coupled peptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007189">
        <property type="term" value="P:adenylate cyclase-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009755">
        <property type="term" value="P:hormone-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24372:SF80">
        <property type="entry name" value="FI21465P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24372">
        <property type="entry name" value="GLYCOPROTEIN HORMONE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 12" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="4" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="9 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="10 12 15" id="KW-0675">Receptor</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="11 12" id="KW-0807">Transducer</keyword>
    <keyword evidence="5 12 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="132"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="161"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="205"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="257"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="305"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="350"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="383"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="14">
        <location>
            <begin position="144"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CAG5093741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="420" mass="47951" checksum="A304F868BF7F5777" modified="2022-05-25" version="1">MSHSGVQCLDFSGNEIDYISHELLNYFPNLKFLNLEKNKISNISSGAFKSFVELVDLNLSGNKLRDLPDDLFNYNLRLQILDLDDITIEDDEENALNRFQELSIIIFKTLRYCQIYGVSSLSDLLSKPLLRVAVWGISVVTLVGNTLVLWGRFIYKDENRVLSIVIRNLAVADMLMGVYLLAIGLEDFNLRDMYNKEANKWISSWQCTFLGMIAMISCEVSVLILSFMSIERFIVIVIAPFSEAPSYFTCRSVTTSMIIIWIIGILLSVIPGIYWRESTRFYGLNGMCFPLHIDEAFMIGWQYSAFIFLGVNLLGLIIIGSVYLGMFLSIRRIRQNTPLTIGDSEIALRFFFIVLTDALCSAPVILLKILALQKYPILPCVHAWVVVFILPVNGAINPILYTFTVPKFKKQFSEYCFRRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HFL3</accession>
    <name>A0A8J2HFL3_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HICCMSTLAB_LOCUS8875</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5097783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HFL3"/>
    <dbReference type="OrthoDB" id="10004641at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235">
        <property type="entry name" value="KRUEPPEL-LIKE TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235:SF142">
        <property type="entry name" value="ZINC FINGER PROTEIN 384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="20"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="102"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="290"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="569"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="736"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="240"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="252"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAG5097783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="792" mass="93137" checksum="E323DA67A72A7C38" modified="2022-05-25" version="1">MAVKSIFCNLEACVSKDEKYACLNPNCKSVFNDKSNRNRHFKHQCGKPPRYKCGYCDQQSHFKTNIKEHCKRRHPNFDITFSSLWLAGNLMESSIQIGPPQYACPNPNCNRVFSKKYNRNAHVNLYCGKPPRFKCPHCDYKSLLKRNIKDHAFRMHSDIDAKVIELYNPAEKLTTMVTIFNDIPGHEEIFPVLEDKNLNKLTIKNIKYACYNPKCSLTFSRESSRDKHYFDCLEKDLQPEEETLDQSAEFSDESKENKEEIPLKNFTEPVKPKKTSKKIVDSSKTAKNRFSCATCSRSYSVKSTLLRHINECGKEKKYKLTTMVAIFNNFPGHKVTFPIKDEDDLNQLMIKNIKYACYNPKCNLKFKSERHRDKHSFDCLKNNLQSGEITHDQNVKFSDESKDNKEKIFSNNSVKPVKPKKTSKKIMHLYKIVDGRFSCCKCSRSYKYRQEFTTMVTIFNEFPSPEEIFPVKEDDDLNKLLIKNIKYACNNLKCNLTFNSERQRDKHSFNCLKNNLQPEEITFDQNAKLRDGSKENKKKISLKNSIKPVKRRKTSKRILLRYKIVNDRYSCCKCSRSYKYKQGLSLHMRFECGKEKKCICPICKNWRTYHKHNLRHHMKLTTMEMSFVFPGYEKTFTVKEEDDLDELKIKNIKYACYNPKCNLTFKSEHQRDEHSFDCLKNNLQSEEIFLDQSAKFRDKSKDNKEKISSKNHVKPVERMKTSKKNVDLCNTVKRRFSCPTCSRSYKYRPGLSAHINYECGKEKKFICPICGNFRAYHKQNLKSHLKKVHGKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HFQ4</accession>
    <name>A0A8J2HFQ4_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Similar to XRCC6: X-ray repair cross-complementing protein 5 (Gallus gallus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HICCMSTLAB_LOCUS7735</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ku70 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5095491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HFQ4"/>
    <dbReference type="OrthoDB" id="3249161at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043564">
        <property type="term" value="C:Ku70:Ku80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042162">
        <property type="term" value="F:telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1600.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.970.10">
        <property type="entry name" value="Ku70, bridge and pillars"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.720.30">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006164">
        <property type="entry name" value="DNA_bd_Ku70/Ku80"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006165">
        <property type="entry name" value="Ku70"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027388">
        <property type="entry name" value="Ku70_bridge/pillars_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005161">
        <property type="entry name" value="Ku_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003034">
        <property type="entry name" value="SAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036361">
        <property type="entry name" value="SAP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016194">
        <property type="entry name" value="SPOC-like_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12604">
        <property type="entry name" value="KU AUTOANTIGEN DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12604:SF2">
        <property type="entry name" value="X-RAY REPAIR CROSS-COMPLEMENTING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02735">
        <property type="entry name" value="Ku"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03731">
        <property type="entry name" value="Ku_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02037">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003033">
        <property type="entry name" value="Ku70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00559">
        <property type="entry name" value="Ku78"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00513">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF68906">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100939">
        <property type="entry name" value="SPOC domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50800">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAP" evidence="12">
        <location>
            <begin position="562"/>
            <end position="596"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAG5095491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="600" mass="69504" checksum="6C76D9D3135F5F86" modified="2022-05-25" version="1">MTAPSQTKSQLKLPEPHHYGNEPIEFGFRVGNLFILDITPKMFTKNEFDVTYFHQCLDTYLNVLKKKLSANSEDWMGLILCNVKKDLLADEYPPDDENDPEPKNVLTLQKFQPVEREMFMDIAKIRNGDIDRFKQLCTDDYSISEAFLHATRTYNRVKKIMASRKVYFLTCEDDPEPSDPQELTSIRINAKNFKDLAIRLHVIGLGDQWKYDLFFKEIEEISENLAARQFRRVDLNELEDNITHKSFVAANLHLRIQSLKIKVTIQAFSRPPRPMTKITASKATNEPLDKYTWWTFDDMFDDEDNNGEEVRFAQNPYDIKRAQNYGGRKILFTPEEVRGLRHVHEQGIDLLGFKPMPERGPMEQISNPYFLGCNSQASKGQIEFFAVLLSKMVEKKLMAVCCITTRKLAPPRLAYLIPYVEYGGFYLFRIPFKHEARDIDELTEKYFFDEENPAPINEEKLGLMKNLVKKLSVKYDVTMFQNPKSQRQQIVLENLALDLPPQELPADTTVPSVEDITDRLSQGNLYDRLQNVICPNVQIVPPAKVIRADDEYVKEVLEAGDFARLTNDKLKAVLRALNLSIQGKKQDFVNRLQEYKATNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HG62</accession>
    <name>A0A8J2HG62_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Similar to DMXL1: DmX-like protein 1 (Homo sapiens)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HICCMSTLAB_LOCUS9336</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5100004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="342131at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043291">
        <property type="term" value="C:RAVE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007035">
        <property type="term" value="P:vacuolar acidification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052208">
        <property type="entry name" value="DmX-like/RAVE_component"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022033">
        <property type="entry name" value="Rav1p_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13950:SF9">
        <property type="entry name" value="RABCONNECTIN-3A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13950">
        <property type="entry name" value="RABCONNECTIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12234">
        <property type="entry name" value="Rav1p_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="RAVE complex protein Rav1 C-terminal" evidence="3">
        <location>
            <begin position="1348"/>
            <end position="1806"/>
        </location>
    </feature>
    <feature type="domain" description="RAVE complex protein Rav1 C-terminal" evidence="3">
        <location>
            <begin position="1840"/>
            <end position="2156"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="3091"/>
            <end position="3132"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="3271"/>
            <end position="3301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="144"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="517"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="825"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1103"/>
            <end position="1146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1745"/>
            <end position="1773"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2215"/>
            <end position="2323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2788"/>
            <end position="2823"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2973"/>
            <end position="3002"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="145"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="162"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="535"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="2225"/>
            <end position="2239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="2256"/>
            <end position="2270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="2286"/>
            <end position="2296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="2303"/>
            <end position="2319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG5100004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="3334" mass="372069" checksum="A0FED18BB7838597" modified="2022-05-25" version="1">MNRHQILSGACNAGDRCYAVGSVEGISFTAYAAGCNIVILASNFERVQIIPGAVHNYIRISCLDCSTDTGKIAAAYENQICIFEPTPLIHSSCSHELEYRWVQTGTLLTDSTITSLSWNLEGTRLLTGGELLQLWHQNIQPFQEEQTKPKTQTEEPPKAVEQNVTGNSSQDPDGVTFSIGGEAESPGPGDSAAANDPGAWNCVWKCRTATPVHLMSFSPDGTLFATTGRNDKLVKIWFENKQLFPMRSMDQLSYCQSLLHDSYSFVYIAHPRAVTHLSWRKTSKYMPKGSVSNMLVTSCRDNICRVWAETIPPEIEGLANMSQFEGSDRHGHHGKHRHHSMHKHRFMQRLKHMKTCFHIRRHAKQQQHQAGHSAPTLPTLPSTYSVHDFHNNYQGFGHYPGMHFHLAASINAETDQASSDQYVTVNIFFIADIPLVPSLITGDPDREPNFILHWLNNKEMYFTMQAEGILQELTRKVVEKEEGLRNHEADHTEHDSEDEHTPSSILSCYGLAHSLEKAPKHQSNVKSGVGGRTTSQDEHSSDEHHTAHTGSSHHSLPYSGHSHQSLSNTTSINSIATDATSTMNHTPDSLDTKIETLLRDWHHNPDLLFSIHPIDGSFLIWHIEWLDEYHPGSFRQAQISFSTRIPNAFPLGDASTMSHNVSMYSHNTGGPLLSIREVAKSVSKPLDHQEIATPLPSLIEQDEEQSTLTSKAGQELLQNVQTFVTSKDNTTTAAEENAAAEANKQNQDAVNDLLKHPSPMVSMVSKHSNGTLNLWQLTFGDKTKFSQVLSIGHACRASGHRFRVNDITCHPVLPLLVTTSHHNIPEFNPPNPENVNTETPETRNQSPTNELLSATGFCSELILWRVDPVGPLSKSGGVSELARINSLEISAFSNVAWIPTLLPSTTLGNLSNSASACFVASDGQCLRVYQAVIDARTLLAEVSISERKSRMMDSMASLSTDISSDDGIRNSIHDRIKIVSQQSTARPGCIIQLDAISDATHDWQNTQFLHVFQEQLITGERNDEKQPGVDPSANDLGLMESTLDAMVDLQQSAIFEEPFYIVVLERTTKGTTVHMWRIVIASQPETNGLTGSMMYVPDSHLVQDEDEEGTPGRHSEGRRSRRQSQTTGGRSRRSSQADYDSSYAHHHHHHHHNSHVLITTTKVCTQDLPLPDGVEVVHASPAAGHLSSSSIYPACFAPYIIVTACNDSTVRFWKCKVSKSEDDQLSYEWREWEMFRKDQESVIDISGTPLNVSAAYSGRIACAYKYGKSFTRPTKADPDSRYVNLCVAIYECESTGGSEWILEDTIHLKNIHLPRMQVDQHLDLSYLYDSRFLQKKQRLTQVLQTLSHEDIRSPRNGDNSEAKTTAGLLAVPSFSTLQSLRKSIIENGNTCPLTQKHLVQLDWVSKEDGSHILTVGVGSKIMLFTPVCSDLAQANMKAMKESKNNNRPILRKTSSLAQPQFVDEIRWMKLRKIKLTTADGLPPLPMQISWVRDGILVVGMDSEMHVYSQWKPNPKSECLHSTLQHQESDEFQASRNLRDEDLRTLAQETSQRRLANVSSIPHLSRVSSINLTMLDIKRRRGLQSDTVTIDYMPDYGLFEASRIACPVLPQYHPKQLMELLHCGKIRWVKAILAHLVKCIATTCGAKQDDENNSKQRSGWTRTRTMSVNYTGTSSPMEQRGSTTQIPEEFFLDYAEIVFITPLPLWRLLKADKESCATQTQDDDKQDYNELFDGHIDEEESLDAMLEESYDSSRQMDRRSSIPDKQSGAHFGPREGRQLSQMLTHSHLPGLSSLDQMHLLALADTVSTCDVDFAERFAIDAAKTAIAKENLTGTPDGTSVSTNSLDDCGLRFLLAMKHYNYLIRCLPLSQRAQFQKQGVSTNNLVWAFHSETEEEMLGLIPSYAKGQPKWSVLKELGVGWWIRSNAVLKTCIEKIAKSAFQQHQDPLDAAIYYLAMKKKNLVWGLFRNKRDDRMTNFFSNDFKEDRWRKAALKNAYALLGKQRFDHAAAFFLLAGSLRDAVEVCLTKLNDIQLAMVISRLYEDDIASPNFKRLLYEEILGCEENKTVTDLTRVHPDPFLRSMALWMLKDYSGSLNTLLLTNVGTQHAQYNDESEKPEGATANPNVFNFYVYLRTHPLLIRQYIASTAQDKKKVTSVVLSGFSYGMESKGQPDKQLTLEDSITPLERQLYFTTAHAHFKAGCPALALEVLSKLPNKVMEPNGEDTPSILNSPSKSQANDSLIDTGMMNWDTPKKVENSDSSSAMDWGSSAMDWSQPVIKEPEELELKWDDDEPGEDAESPPLSMDTEKKTEQPKEEKRTESPKPVGQLDIMAQQLKFVACLKILMEELSTLATGFEVDGGQLRYQLYIWLEREVDALKQLCNYSVNTDGDVSNITEYDNEDIGPYKPGEQMTLHEILLSEKLDFEAKVQRAARRKKWLKANETLLRTMLSYCSLHGASGGGLASVRMELVLLLQELQQEKTQQQLLSPLPFPTTLPLLSASVACNKTVVADPVRHLQALAHDMLQTLIELRNPPTLSNNGTCYEIFTLRDLTVALSSCIYQSLCDSDTTKNQQPEIFPAIAEIESFSGGHLVASNKVTRRYSLDETVTITTPPSKWPGVTNLRALLAREKDEDTPKLNILLCEAFVSTYMSLFVYALASCDSHLLFRLVGHHFDNNTWSCLFGGGVKKLVRIASTNRNDSASSVVERADSISGEIQAAAGGVWSTMTSLTKQRVKLNMKLLGQFTGQTPNIKEDKPTYREQFVSPQMSMVSYFLMKPRIESEYADEIDYDSSDSAVSDLGTSDEEEDVFDTNAKPKSKPKDNTEHLNSNGYSWCVMRLAIVKILEQQLQNFLNVAGIELQELPVSSPLIHAILGVVAQWEDSLRDELEAKGPPPSNYILGCTPDPNPSPGKPAIHKYRALLEKENTPFNTRLASAAPVNRLWRYLVRQESVQDIFIRAVFGKHRSLSVMMENSQSAVDSATRSGSEDKGSDSGTTSLPEPVNPGLMALATPREVQEMDISLLLELPSWLEDECEFDIINLNRSVEPEPIQPTSFLVIQTAADRPLLAQNPLPNTPQPQSGIASQSGRGASVILKHKTDGIRRLSAHPLLPLYLTGSQDGSVSLWEWGHQTAVSTPRPAGTFAKVTRVHFSQHGNKFGVADSDGHLSLFQVACREGTSRPFFNYQCHSKVTADFVFLGACSLVATAGHGSEGRNVALWDTLLPQNKSLVQGFTCHDQGASSVILAPQHQLLISGGKKGDINIFDVRQRQQRHRFQAHESAIKCLALDPHEEFFVSGAGDGDIKLHVDSAGRLFSCGADGSMKVRQLPERDCVVHTYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HG80</accession>
    <name>A0A8J2HG80_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Isoforms A/B/D/L (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HICCMSTLAB_LOCUS8888</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5097809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HG80"/>
    <dbReference type="OrthoDB" id="10004641at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13909">
        <property type="entry name" value="zf-H2C2_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="23"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG5097809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="85" mass="9734" checksum="72AC6C1C33651EAE" modified="2022-05-25" version="1">MWRSGGGLGKGFGGSATGNPEGFNCPACGRVYKLKSSLRNHQKWECGKEPQFQCPHCVYRAKQKMHIARHMERMHKEKIFKQELV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HG98</accession>
    <name>A0A8J2HG98_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Similar to U-scoloptoxin(01)-Cw1a (Cormocephalus westwoodi)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HICCMSTLAB_LOCUS7087</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5093761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HG98"/>
    <dbReference type="OrthoDB" id="7426044at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002557">
        <property type="entry name" value="Chitin-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036508">
        <property type="entry name" value="Chitin-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052976">
        <property type="entry name" value="Scoloptoxin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22933:SF31">
        <property type="entry name" value="FI18007P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22933">
        <property type="entry name" value="FI18007P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01607">
        <property type="entry name" value="CBM_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57625">
        <property type="entry name" value="Invertebrate chitin-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50940">
        <property type="entry name" value="CHIT_BIND_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035173671" evidence="2">
        <location>
            <begin position="16"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="3">
        <location>
            <begin position="132"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="231"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="231"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="241"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="299"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG5093761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="328" mass="37662" checksum="BB26053C92431D42" modified="2022-05-25" version="1">MHRVLLLTWVAIAAAQNHYNLDTRSVSFPGKPTYGPLYNSPGLGQASGGYRDDSYEDNVVTPTPSPTPLYRPAQQPAYRKPNEGSIRVLTGGRQGPIRGASYAVQNPQLEEEPLEEEKEEPDRLSLLLPQSKFDCVGKQTGYYADEELNCEVFHYCQDNAKHSWICPEGFTFHQVHLICMPPNGDISCKKSSQYHFVNEYLYKPLNLQEAESKPNVTLRYSERYFPGDIFTDERESEDYHQTPNPRRTHHNSQLYSNQPSQTTLNSIPSIARPSPTPQGLPQYRLPSNQVFRSPEEVNIPLQQRRPQPQQQILRRFPQVRPDEEDYEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HH89</accession>
    <name>A0A8J2HH89_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">V-type proton ATPase subunit H</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HICCMSTLAB_LOCUS7650</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment. Subunit H is essential for V-ATPase activity, but not for the assembly of the complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the V-ATPase H subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5095320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HH89"/>
    <dbReference type="OrthoDB" id="10263554at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000221">
        <property type="term" value="C:vacuolar proton-transporting V-type ATPase, V1 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00256">
        <property type="entry name" value="VATPase_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.150:FF:000001">
        <property type="entry name" value="V-type proton ATPase subunit H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.150">
        <property type="entry name" value="V-type ATPase, subunit H, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004908">
        <property type="entry name" value="ATPase_V1-cplx_hsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011987">
        <property type="entry name" value="ATPase_V1-cplx_hsu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038497">
        <property type="entry name" value="ATPase_V1-cplx_hsu_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10698">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10698:SF0">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11698">
        <property type="entry name" value="V-ATPase_H_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03224">
        <property type="entry name" value="V-ATPase_H_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF032184">
        <property type="entry name" value="ATPase_V1_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="4 6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="226"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="ATPase V1 complex subunit H C-terminal" evidence="9">
        <location>
            <begin position="328"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="451"/>
            <end position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00046225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR032184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF11698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAG5095320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="473" mass="53938" checksum="3E984A8CE0461001" modified="2022-05-25" version="1">MADRANINQIIPALPEEKHAATSVLQQQVADIRSQKINWQSYNQSQMISQEDYDFIVGFDISDPAVKDAKLKQNPGQAAKTFLNLLSHISKDQTIQYILVMIDDMLQHASRKRESVWSPFLNLLNRQDGFIMNMTSRIIAKLACWSHAQMEEADLNFYLTWLKDQLKLSFEAVQESQMHAEVLQDVVPTEPAEAGDLHEMPSPNNEYIQSVARCLQMMLRVDVYRFAFISVDGISTLLSVLFNVIPILADILSDSVKEKVTRIILAVFRNLIEKVGDRQVAKEHCIAMVQCKVLKQLSILSQRKFDDEDITEDIEFLNDKLQASVQDLSSFDEYSTQVKSGRLEWSPVHKSSKFWRENASRLNEKNYELLRILVHLLETSKDPLVLSVASFDIGEYVRHYPRGKHVLEQLGGKQRVMQLLSHEDPNVRYEALIAVQKLMVHNWEYLGKQLEKEQTGTGGTSGPKPGAQVPAKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HHD8</accession>
    <name>A0A8J2HHD8_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="16">ANK repeat and PH domain-containing protein (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">HICCMSTLAB_LOCUS7828</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5095678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HHD8"/>
    <dbReference type="OrthoDB" id="435430at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08834">
        <property type="entry name" value="ArfGap_ASAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07604">
        <property type="entry name" value="BAR_ASAPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13251">
        <property type="entry name" value="PH_ASAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11821">
        <property type="entry name" value="SH3_ASAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.60:FF:000036">
        <property type="entry name" value="Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000322">
        <property type="entry name" value="Uncharacterized protein, isoform B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.950">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.150">
        <property type="entry name" value="Arf GTPase activating protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037278">
        <property type="entry name" value="ARFGAP/RecO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001164">
        <property type="entry name" value="ArfGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038508">
        <property type="entry name" value="ArfGAP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043593">
        <property type="entry name" value="ASAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035836">
        <property type="entry name" value="ASAP1-like_SH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004148">
        <property type="entry name" value="BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037844">
        <property type="entry name" value="PH_ASAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45854:SF3">
        <property type="entry name" value="ARFGAP WITH SH3 DOMAIN, ANK REPEAT AND PH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45854">
        <property type="entry name" value="ASAP FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01412">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16746">
        <property type="entry name" value="BAR_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00405">
        <property type="entry name" value="REVINTRACTNG"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00105">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57863">
        <property type="entry name" value="ArfGap/RecO-like zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50115">
        <property type="entry name" value="ARFGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 8" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 9" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PH" evidence="14">
        <location>
            <begin position="302"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="domain" description="Arf-GAP" evidence="15">
        <location>
            <begin position="423"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="8">
        <location>
            <begin position="621"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="13">
        <location>
            <begin position="963"/>
            <end position="1027"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="713"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="860"/>
            <end position="952"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="245"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="713"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="744"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="899"/>
            <end position="920"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CAG5095678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="1027" mass="114538" checksum="461027962EA5A6DF" modified="2022-05-25" version="1">MPGLIAVSEFVEETREDYNSPTTSTFVSRMPQCRQTITALEETLDFDREGLTKLKKAIKAIHNSGNAHVDNEVYLGRALEKMGDAALKEQEHDIGAAFFKFAVVTKELSALMKTLMQNINNIVMFPLDSVLKGDLRGVKGDLKRPFEKAWKDYEAKYAKIEKEKKQHAKEAGLIRSEVTPAEIADEMEKERRLFQLQMCEYLIKVNEIKTKKGIELLQHLVEYYHAQTNYFQDGLKTIEHFGSYIADLSVKLQKIRQTQDEERRRLTELRSLLRSSGCDKELNANASVGYSLHQLQGDKQHGVTRSGHLLKKSEGKMRRVWQKRRCAVQAEGYLDICHADENKPPTRVNLLTCQIKLVPDDKRGFDLISYNRTYHFQAEDEADQRAWMSVLVNCKERALLKAFDASGKAEAGQGNPSLVELQQAIIRCVLRLDGNDKCCDCSSQNDATWLSTNFGIIVCIECSGIHRDLGVHISRIQSLTLDNVGTSQLLLARFMTNQAFNEVMEATLNHHHKPTPTSTMEERYEFIRAKYVDKKYVLRTCEDERDLLSDLEHAVNNKDLQHLLQVYGEKVDLAAPLPTSDVGETALHLAILREIGGNCLHIVDFLIQNMPVGNIDKITSEGETALHLSARHDRAEAMKLLLRAGADPTLRNKQEKTPLDIAQEMGHPTCKELLSNALQRQKTLFDNVNIDWNLSHDEGSTDFSDDETIIEDRNGCLTPEKKSRSRPPSYAGGGGSGPGDSPITLRSRSSTCDSLQSGSSPNSITSRQQMPPPPPPQSRKPVVIPSPMGPPEYSLNIHGSLKKRVAPPPPPGNGGTMLTAHYGTLPSSASLASSSHSRTTSEPILAGNALHSLPHSLNTLNSLHHKRSPSSDSSVSHSMDKSNTSTLQRPRNPPPPAPSAGSSARLSNGRSSESLSSMCSEHGIGNPIPPPRKRRDRSRLESYAEEPSSLLPNLNLPMTSSLNGLRRCRALYDCDADNEDELSFREGEVIIVTNEQTDDDNWMEGALERAPERRGMFPISFVHMLQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HHS2</accession>
    <name>A0A8J2HHS2_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PEST proteolytic signal-containing nuclear protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HICCMSTLAB_LOCUS8521</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="1">May be involved in cell cycle regulation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Interacts with UHRF2/NIRF.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5097059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HHS2"/>
    <dbReference type="OrthoDB" id="10068198at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029169">
        <property type="entry name" value="PCNP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16523">
        <property type="entry name" value="PEST PROTEOLYTIC SIGNAL-CONTAINING NUCLEAR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16523:SF6">
        <property type="entry name" value="PEST PROTEOLYTIC SIGNAL-CONTAINING NUCLEAR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15473">
        <property type="entry name" value="PCNP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0007">Acetylation</keyword>
    <keyword evidence="9" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0832">Ubl conjugation</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="60"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="100"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="122"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAG5097059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="183" mass="20701" checksum="D283FE8CE7BEE38B" modified="2022-05-25" version="1">MSRRNQSEDYRKGPNSYRGDRDGSDDSSDEDVRNYRRERDRSPLRRRASDDRNRADRETTSSYESSRDTSMQQKQKLAFGFSKKSTSTDAKKGIQIKLGPATKPTAKPIAPTKTTVASVFNADDDDEPEEMPAEARMRMRNIGRETPTSAGPNSFGKTKQGFCDSKKIFEKTLKKAMDEANNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HI96</accession>
    <name>A0A8J2HI96_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Similar to MPPE1: Metallophosphoesterase 1 (Ailuropoda melanoleuca)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HICCMSTLAB_LOCUS10866</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the metallophosphoesterase superfamily. MPPE1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5102140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HI96"/>
    <dbReference type="OrthoDB" id="9984693at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033308">
        <property type="entry name" value="PGAP5/Cdc1/Ted1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13315">
        <property type="entry name" value="METALLO PHOSPHOESTERASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13315:SF0">
        <property type="entry name" value="METALLOPHOSPHOESTERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0464">Manganese</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="350"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="11">
        <location>
            <begin position="62"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAG5102140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="384" mass="44646" checksum="6051D604BD214590" modified="2022-05-25" version="1">MVNFTAYKHYLLEAFIAALCLVVYCEYLIYYVVLAQCSWPDIDSFKADPSIKPGILEEKPVKIMFIADTHLLGSKTGHWFDKLRREWQMYRTFQTSMVLYKPEIVFFLGDIFDEGARSSEDEFQTYVNRFHSLFSVPKNTYSYVLAGNHDMGFHYAITPYKNQRFINSMKSPNVKRVSIRGTHFILINSMAFEGDGCFLCRPAEVKIHEISKQLKCAKGIKSDCAKSGKTIIEKYSRPILLQHFPMYRESDASCKELDQAPDEIKNIKFRERWDSLSKESSVQLLELLNPRLIIDGHTHHGCRQLHGEDTLEITIPSYSWRNKNNPSFLMGVFTPNNYALSKCYMPVENTVILIYTVGGICIVFYLLFRAKQKMNCRHHFLKLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HIG8</accession>
    <name>A0A8J2HIG8_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS10988</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5102384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HIG8"/>
    <dbReference type="OrthoDB" id="7694438at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="68"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="331"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="200"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="81"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="350"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5102384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="401" mass="46549" checksum="56D680019196118D" modified="2022-05-25" version="1">MAEFDAKINMSLDEIIKLDRREKKKNVNGKPAIKRNLRRNNTRATGRPRNAAGVGTKTFNANFKKNFNKNGVTPNAKKRNQSQAWRLQRGRNANQPNSGFITKRYKQQQQQNGVVKRAKPGFVLKNKQQQQQINKKALAVRRTKNPRFGLTRSRSRNNLSTIPVKNFSSNSRVLKKTNSLPDLRNPNSVHNRLGYQSLNQVAYRNRVKRAKKLLLQLQNKQKRADDQLVYRPAKALTALQRRALERRQQQQLLSTQQRMYNAGGLRSDQILRTQRRAQYAQKLMRQNATRMNPNVNFMCTLGDEYSMNRQMTFNPAPPRNLANMRHMSRERSPFRPTMQNSLPRPQFIRSRSRSRSRSRSRAQNVASIPANPDDRTFSQVMYSVSNNLGVTGRTLNDRFSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HIU8</accession>
    <name>A0A8J2HIU8_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">2-oxoglutarate dehydrogenase, mitochondrial</fullName>
            <ecNumber evidence="3">1.2.4.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">2-oxoglutarate dehydrogenase complex component E1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HICCMSTLAB_LOCUS11119</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="7">The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2). It contains multiple copies of three enzymatic components: 2-oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3).</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the alpha-ketoglutarate dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.4.2" evidence="3"/>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5102647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HIU8"/>
    <dbReference type="OrthoDB" id="413077at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045252">
        <property type="term" value="C:oxoglutarate dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004591">
        <property type="term" value="F:oxoglutarate dehydrogenase (succinyl-transferring) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02016">
        <property type="entry name" value="TPP_E1_OGDC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12470">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1150">
        <property type="entry name" value="TPP helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032106">
        <property type="entry name" value="2-oxogl_dehyd_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011603">
        <property type="entry name" value="2oxoglutarate_DH_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001017">
        <property type="entry name" value="DH_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23152:SF4">
        <property type="entry name" value="2-OXOADIPATE DEHYDROGENASE COMPLEX COMPONENT E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23152">
        <property type="entry name" value="2-OXOGLUTARATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16078">
        <property type="entry name" value="2-oxogl_dehyd_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00676">
        <property type="entry name" value="E1_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000157">
        <property type="entry name" value="Oxoglu_dh_E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="4" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="2-oxoglutarate dehydrogenase E1 component N-terminal" evidence="12">
        <location>
            <begin position="33"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="domain" description="Dehydrogenase E1 component" evidence="10">
        <location>
            <begin position="209"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="domain" description="Transketolase-like pyrimidine-binding" evidence="11">
        <location>
            <begin position="598"/>
            <end position="699"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00040267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00042984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF16078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAG5102647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="709" mass="80441" checksum="82DC24FB85212F64" modified="2022-05-25" version="1">MFYILRSFKVSNCKYIFRKIITMNTSIKRQKETFLNPGNGIFLEETYNSWLRDPQSVEKSWDNYFRSNNFSGQKPLDIDATIRAYQARGHLIADIDPLGIQNPEVAKLQGTPDPAPAVVVRRHLEGVTEADLEKKYTLPSSLTVIGGTEKSLKLREILTRLNKIYCGHLGLEYTYIPDFEVLDWLRHKFEVPGAWELSGDHRKYIWQNVMRAVTFESFLAKKYGAEKRFGLEGCESFVPAIVQCFESSAEHGVEAAVIGMAHRGRLNTLVNICSKPMHQLFVQFNPIPMEGLGSGDVKYHLGTHSERLLERSGKKIRVAVLGNPSHLEAVSPLVVGRVRAEQVVHQDFEGKKSMAVLVHGDAAFAGQGICYETMHLTNLPDYTTGGVIHAVINNQIGFTTDPRYSRSSTHCTDVARVVNAPIFHVHADDPDLVAYCSKVAAEYRTIYHNDVVLDIVGYRRNGHNEMDEPMLTQPLMYKCIKSHPNVLKIYSDKLLKEGIIDEDFIKKETNEYLEHCESEFKKAQTISAMQMSDWHDVPWSEFFANQNPMKKIPPTGISTADIKKIVTAFSTSPEGIEPHAQVFRVLERRKKLIDQERFDWAMGEALAIASLLKEGCHVRLSGQDVERGTFSHRIHIIHDQSRDKTWKNILHDIFPNQALYTVTNSPLSEFGVLGFELGYSAYDHNTLTLWEAQFGDFANNCQVNFLKSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HIX6</accession>
    <name>A0A8J2HIX6_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Trypsin-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HICCMSTLAB_LOCUS6397</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase S1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5092841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HIX6"/>
    <dbReference type="OrthoDB" id="6755574at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000146">
        <property type="entry name" value="Serine protease 53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050430">
        <property type="entry name" value="Peptidase_S1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033116">
        <property type="entry name" value="TRYPSIN_SER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24276:SF98">
        <property type="entry name" value="FI18310P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24276">
        <property type="entry name" value="POLYSERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00135">
        <property type="entry name" value="TRYPSIN_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 10" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="7 10" id="KW-0720">Serine protease</keyword>
    <keyword evidence="5 11" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035317503" evidence="11">
        <location>
            <begin position="19"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="12">
        <location>
            <begin position="24"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAG5092841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="255" mass="28134" checksum="6DB6E3A7BC60E976" modified="2022-05-25" version="1">MLRIVIISLILCIYGAESKKPSKIVNGAIAQLGEFGHQASLRVYDQHICGGSIISHTHILTAAHCCVDNDQTMSVYQDMTVLTGTNDKSGQQSGQLHKVINIVCHEHYDPKNNWINDIAILTLAKSITFNRFQHSIKLPSRNLPPNTRVMASGWGALTFATPSSAPLILQKLDMRIVSNTECSNALSNNIYPGQICVLKGWGTGVCVGDSGGPLTYNNEVHGIASWVVPCAEGYPDVFTRVYYYLSWIQQHTRQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HJ24</accession>
    <name>A0A8J2HJ24_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similar to Icarapin-like (Apis mellifera)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS9353</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5100038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HJ24"/>
    <dbReference type="OrthoDB" id="6346805at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5100038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="138" mass="15300" checksum="87849D9C1C5274D4" modified="2022-05-25" version="1" fragment="single">MVKQMREEMNKMFAGFPSLDDLKPLGGIPKDAINKTSSKSETKVINGHKVTINETTFSDGTNNSNTFVRFKVIHVRPENETSVETGSDTSPESVEVVETEVDEEPNPTSKDETTNRSVEAVEDWKNDIPDSPVDDLKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HJF2</accession>
    <name>A0A8J2HJF2_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS9025</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5098083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HJF2"/>
    <dbReference type="OrthoDB" id="6620433at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47771:SF13">
        <property type="entry name" value="HDC01644"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47771">
        <property type="entry name" value="LD27203P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035173672" evidence="1">
        <location>
            <begin position="18"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5098083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="238" mass="27282" checksum="ADCFC7C799A26B81" modified="2022-05-25" version="1">MFSIVWMSVALIAVASASDYHDHEPHRTYEEKVNPVEVPVYKKYAIPIPHPVAVKVPQEIKIPMPQPYHVPVQIPQPYPVEVIKHVDVPVEKPEPFVVEKKVPFIVEKPYAVELIMNQRVIVLLAICFTTTASENQNIPQRVIVGVPEHIRVPVPEPYLVQFQVPHPFPVEVIKHVEVAVEKPEPVVVDKQVPYIVEKPFAVTVEKHFPVTIPKPYPVHVPVYKHVFHHQFKSKGRKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HJT8</accession>
    <name>A0A8J2HJT8_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 13">Glucose-6-phosphate 1-dehydrogenase</fullName>
            <ecNumber evidence="5 13">1.1.1.49</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">HICCMSTLAB_LOCUS10081</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Catalyzes the rate-limiting step of the oxidative pentose-phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis.</text>
    </comment>
    <comment type="function">
        <text evidence="1">Cytosolic glucose-6-phosphate dehydrogenase that catalyzes the first and rate-limiting step of the oxidative branch within the pentose phosphate pathway/shunt, an alternative route to glycolysis for the dissimilation of carbohydrates and a major source of reducing power and metabolic intermediates for fatty acid and nucleic acid biosynthetic processes.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>D-glucose 6-phosphate + NADP(+) = 6-phospho-D-glucono-1,5-lactone + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15841"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57955"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:61548"/>
            <dbReference type="EC" id="1.1.1.49"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:15842"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 13">Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 1/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 13">Belongs to the glucose-6-phosphate dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.49" evidence="5 13"/>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5101008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HJT8"/>
    <dbReference type="OrthoDB" id="60984at2759"/>
    <dbReference type="UniPathway" id="UPA00115">
        <property type="reaction ID" value="UER00408"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004345">
        <property type="term" value="F:glucose-6-phosphate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009051">
        <property type="term" value="P:pentose-phosphate shunt, oxidative branch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.360.10:FF:000013">
        <property type="entry name" value="Glucose-6-phosphate 1-dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000111">
        <property type="entry name" value="Glucose-6-phosphate 1-dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00966">
        <property type="entry name" value="G6PD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001282">
        <property type="entry name" value="G6P_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019796">
        <property type="entry name" value="G6P_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022675">
        <property type="entry name" value="G6P_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022674">
        <property type="entry name" value="G6P_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00871">
        <property type="entry name" value="zwf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23429:SF0">
        <property type="entry name" value="GLUCOSE-6-PHOSPHATE 1-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23429">
        <property type="entry name" value="GLUCOSE-6-PHOSPHATE 1-DEHYDROGENASE G6PD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02781">
        <property type="entry name" value="G6PD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00479">
        <property type="entry name" value="G6PD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00079">
        <property type="entry name" value="G6PDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00069">
        <property type="entry name" value="G6P_DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 13" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 13" id="KW-0313">Glucose metabolism</keyword>
    <keyword evidence="9 13" id="KW-0521">NADP</keyword>
    <keyword evidence="10 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035191134" description="Glucose-6-phosphate 1-dehydrogenase" evidence="14">
        <location>
            <begin position="18"/>
            <end position="879"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-6-phosphate dehydrogenase NAD-binding" evidence="15">
        <location>
            <begin position="401"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-6-phosphate dehydrogenase C-terminal" evidence="16">
        <location>
            <begin position="577"/>
            <end position="868"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00020444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU362120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF02781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CAG5101008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="879" mass="102276" checksum="17E357BCE3D0A3F9" modified="2022-05-25" version="1">MDKLFILLICMFKCCLTFEGNLELKKLGEKEYLLLKAKSNLPVHGPCWHKALKELKNNCNKLNDQEHSLLALRLANCFLEDSGHITYDCHFSETEADRRQCINSMSDRAFGVYNEFYTHTTHICFYLNHELWQIETERTFQNLYAASSKMTEQLVEASKVQGSMLESQKEGLKIQNELLVNGKELGTVIKTSANSVNEMVLDFKESSKSQQALLNEIFSYMRAFQDWIVGEVSWFQSIVYYSIACIICALFSSSKRTADSRITLFVVLSLNVTLERMLVQYNINVTSPEDKIQLAYYTWGLRKIVLLLCMSILLYSYYSYRDEHMENNRVLRRIEKKLHALQEAPQPFRYRTRLAVKRLNESKGASTEESLKIIWHDLKCEEMDRLEGTHFYGQRAHIFITLGASGDLAKKKIYPTLWWLFRDNLLPKTTTFFGYARSKLTLQDLRDKCHQYMKVKPGEEEKYEAFWKLNYYVQGPYDSDKSFEHLNSELMKFENGSEANRLFYLALPPSVFEEVTVHIKNKCMGKKGWTRIIIEKPFGRDAPSSQRLSDHLASLFNEEQIYRIDHYLGKEMVQNLMTLRFGNRIFSPTWNRDNIASVQITFKEPFGTQGRGGYFDEFGIIRDVMQNHLLQILSLFAMEKPASCCPNDIRNEKVKVLKCIKPLELDDVVLGQYVGDPDAEDPEARLGYLDDPTVPSNSTTPTYAAAVLKINNERWDGVPFILKCGKALNERKADIRVQYRDVPGDIFDGKAKRNELVIRVQPGEALYIKMMTKTPGITFNMEETELDLTYDKRYKNIKLPDAYERLILDVFCGSQMHFVRSDELSEAWRIFTPLLHQIENERIPPIPYKYKSRGPKEADAMAKKNNFVYYGSYKWPEHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HKI3</accession>
    <name>A0A8J2HKI3_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS10840</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5102088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HKI3"/>
    <dbReference type="OrthoDB" id="445896at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5102088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="84" mass="8927" checksum="224853EC6AAB6BC5" modified="2022-05-25" version="1">MEAGPRTGICPSGGQAGNVTAGQAQFIQAHDPALEAAPAEDGILFARVNVPELNVTKCLQFPKDQLVWDVKQQCLASLPKISIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HKS9</accession>
    <name>A0A8J2HKS9_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">mitogen-activated protein kinase kinase</fullName>
            <ecNumber evidence="8">2.7.12.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HICCMSTLAB_LOCUS10172</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="7">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.12.2" evidence="8"/>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5101099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HKS9"/>
    <dbReference type="OrthoDB" id="10252354at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004708">
        <property type="term" value="F:MAP kinase kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030707">
        <property type="term" value="P:follicle cell of egg chamber development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010508">
        <property type="term" value="P:positive regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043068">
        <property type="term" value="P:positive regulation of programmed cell death"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051239">
        <property type="term" value="P:regulation of multicellular organismal process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051403">
        <property type="term" value="P:stress-activated MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000040">
        <property type="entry name" value="Dual specificity mitogen-activated protein kinase kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000158">
        <property type="entry name" value="Dual specificity mitogen-activated protein kinase kinase 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48013">
        <property type="entry name" value="DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48013:SF11">
        <property type="entry name" value="LICORNE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="48"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAG5101099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="325" mass="36680" checksum="AF85F0F36DAD6399" modified="2022-05-25" version="1">MAARKGKRNLKLQVSEEAPVNITPPRNLDKRTTITIEDKTFEVEADDLETICILGRGAYGIVDKVKHKQSATVNNQEQKRLVMDLDISMRSSDCPYTVQFYGALFREGDVWICMEVMDMSLDKFYVKAYKNGCSIPEDILGKIALSVVSALHYLYSQLRVIHRDVKPSNILINRKGEVKICDFGISGYLVDSVAKTIDAGCKPYMAPERIDPSGNPSHYDIRSDVWSLGISLVELATGRFPYESWGTPFEQLKQVVKDDPPKLPSGKFSQPFEELITKCLMKDFTARPNYSQLLELDFIVEHSKKDTDVAGFVDKILNLPDPEQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HLF3</accession>
    <name>A0A8J2HLF3_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA helicase</fullName>
            <ecNumber evidence="3">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">HICCMSTLAB_LOCUS10612</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoplasmic ribonucleoprotein granule</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DNA2/NAM7 helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="3"/>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5101710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HLF3"/>
    <dbReference type="OrthoDB" id="6513042at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036464">
        <property type="term" value="C:cytoplasmic ribonucleoprotein granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000184">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903313">
        <property type="term" value="P:positive regulation of mRNA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd21407">
        <property type="entry name" value="1B_UPF1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18039">
        <property type="entry name" value="DEXXQc_UPF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18808">
        <property type="entry name" value="SF1_C_Upf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21400">
        <property type="entry name" value="ZBD_UPF1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.230:FF:000001">
        <property type="entry name" value="Regulator of nonsense transcripts 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000097">
        <property type="entry name" value="Regulator of nonsense transcripts 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045055">
        <property type="entry name" value="DNA2/NAM7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041679">
        <property type="entry name" value="DNA2/NAM7-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041677">
        <property type="entry name" value="DNA2/NAM7_AAA_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006935">
        <property type="entry name" value="Helicase/UvrB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047187">
        <property type="entry name" value="SF1_C_Upf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040812">
        <property type="entry name" value="UPF1_1B_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018999">
        <property type="entry name" value="UPF1_CH/ZBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887">
        <property type="entry name" value="DNA2/NAM7 HELICASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887:SF364">
        <property type="entry name" value="REGULATOR OF NONSENSE TRANSCRIPTS 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13086">
        <property type="entry name" value="AAA_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13087">
        <property type="entry name" value="AAA_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04851">
        <property type="entry name" value="ResIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18141">
        <property type="entry name" value="UPF1_1B_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09416">
        <property type="entry name" value="UPF1_Zn_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51997">
        <property type="entry name" value="UPF1_CH_RICH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0347">Helicase</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 12" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Upf1" evidence="14">
        <location>
            <begin position="99"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="34"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="C3H" evidence="12">
        <location>
            <begin position="107"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="CC/SHH/C" evidence="12">
        <location>
            <begin position="121"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="C4" evidence="12">
        <location>
            <begin position="167"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1007"/>
            <end position="1065"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1088"/>
            <end position="1117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="39"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1027"/>
            <end position="1065"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1088"/>
            <end position="1097"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="1100"/>
            <end position="1117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CAG5101710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="1117" mass="125434" checksum="2A210EB84197B22E" modified="2022-05-25" version="1">MSVDAYGPSSQTLTFLDTEEADLIGADTQGSEFDFTDFTLPSPSQTQASQHDSAQSQPNQSVQINGTNGSSALDLKISGAAQNLAELQFEEEEEEAYYNRDLPDHACKYCGIHEASCVVMCNVCRKWFCNGRGNTSGSHIINHLVRAKHKEVTLHRDGPLGETVLECYSCAVRNVFVLGFIPAKADSVVVLLCRQPCAAQSSLKDMNWDQEQWKPLIEDRSFLSWLVKIPSEQEQLRARQISAQQINKLEELWRDNVDATFQDLEKPGVDEEPQQVLLRYEDGYQYQNIFGPLVKLEADYDKRLKESQTQENIEVRWDVGLNKKTIAYFMLAKTDGDMKLMHGDELRLRYLGELHKPWSGIGHVIKIPDNYGEEVGIELKNNSGAPTECVSNFVVDFIWKSTSFDRMQLALRKFAVDDTSVSAYIYHRLLGHEVEEVLFRCHLPKHFSAPNLPDLNRSQVYAVKHAVQRPLSLIQGPPGTGKTVTSATIVYQLVKQNGGPVLVCAPSNTAVDQLTEKIHKSNLKVVRLCAKSREAIDSPVSFLALHNQIKNMETNTELQKLQQLKDETGELSSADEKRYRLLKKASEKELLEAADVICCTCVGAGDPRLHRLKFHSILIDESMQATEPECMVPVVLGAKQLILVGDHCQLGPVVMCKKAARAGLSQSLFERLVVLGIRPFRLEVQYRMHPDLSRFPSNFFYEGSLQNGVCADERKLVKIDFPWPVPEKPMFFYVTQGQEEIAGSGTSYLNRTEASNVEKITTRFLRCGVKPEQIGVITPYEGQRAYLVQYMQYQGSLHAKLYQEIEVASVDAFQGREKDIIIMSCVRSNEHQGIGFLNDPRRLNVALTRAKYGIIIVGNPKVLSKQPLWNHLLNFYKEQKVLVEGPLNNLKESMIQFAKPKKLVNSANPGSHFMSTSMYDAREALIPGSVYDRTGQVNGQSHNPYYQRNIPLDMFSRTHDTISYISPERAQAAINNVPVPVGMFMNMAHVPPRFYNQHQQALQARQNVQRNRRGVKKMPVGPRMGKFSQSDINTQPYNSQGGALPLTQGTTQGMSQPGFSLSQPGLSQAELSQDSFAVGDFQSQMDGLLSQDSTYQGDRSGFYQGQSQPSGQFSQPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HLI7</accession>
    <name>A0A8J2HLI7_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="3">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HICCMSTLAB_LOCUS10041</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase C19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="3"/>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5100968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HLI7"/>
    <dbReference type="OrthoDB" id="289038at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000064">
        <property type="entry name" value="Putative ubiquitin carboxyl-terminal hydrolase 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024729">
        <property type="entry name" value="USP7_ICP0-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029346">
        <property type="entry name" value="USP_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14533">
        <property type="entry name" value="USP7_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12436">
        <property type="entry name" value="USP7_ICP0_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Ubiquitin carboxyl-terminal hydrolase 7 ICP0-binding" evidence="8">
        <location>
            <begin position="116"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin carboxyl-terminal hydrolase C-terminal" evidence="9">
        <location>
            <begin position="368"/>
            <end position="579"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF14533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAG5100968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="595" mass="69489" checksum="FC7A8C9BF1BAACB7" modified="2022-05-25" version="1">MKESKLPRKVITKIKKEWKTHDSIATISFPHVFCNLVDRLQEEKRLEYIRRKERNDAHLYMTVNVLLEDSFDGHQGNDLYDPERALYRVFRIRKQATLHEFLELLSDSLKYPIEQIRVWPFSSRTNQTCRPTLIEAEADLQKSMSMCAENANPWPVFVELVPPDSGLTALPPFDKDTDVLLFFKLYDPKNKKIHYAGHHYMPVTAKVQELIPILNERAGFPPDTELALYEEIKPNMVEKIENMTESLEKVLEELMDGDIIVFQKEERDNEMYELPTCRDYFKDLFYRVEVTFCDKSIPNDPGFTMELSLRMTYDQMAKAVAQRVGTDPYLLQFFRCQNYKDLPGHPLKCTFEGTLKDLVAYCKPKTKKIFYQQLSIRVNELENKKQFKCIWVGLSLKEEKEIILYPNKNGTVATLLEEAKKQVELSENGSGKLRLLEINCNRLLPGPKEDVPLENLTTIGTKAYRIEEIPKDEVNLADDEMLVPVAHFHKDVFSPFGIPFMFKIKHGEPFTKVKDRLLKKLGVQEKEFEKFKFAIVSMGKPQFITEEADYYINLAEFRTTSSQALQRPWLGLDHVNKAPKRPRINYLEKAIKIYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HLV0</accession>
    <name>A0A8J2HLV0_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS11290</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5102999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HLV0"/>
    <dbReference type="OrthoDB" id="6629168at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5102999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="174" mass="19700" checksum="85DB5751EBA148E8" modified="2022-05-25" version="1" fragment="single">MLFDNTVLPEEKLKIAKKIKSIVAVKKSNEQYSVPYKTITSLSEENPSDFATPNSLKVVNNTAERGVALTRRFSEAFTSNEDERQKVFQTDSITVRNINYVDLRDAFTLLSNTAAATQAGLVHVWTPVIFFEQGNNKPFISRPDLQGEIEFYGGSYGTFINNTKRHLLIIPEHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HMI8</accession>
    <name>A0A8J2HMI8_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DNA-directed RNA polymerase subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">HICCMSTLAB_LOCUS11697</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="8">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8 12">Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5103813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HMI8"/>
    <dbReference type="OrthoDB" id="282270at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001193">
        <property type="term" value="P:maintenance of transcriptional fidelity during transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006283">
        <property type="term" value="P:transcription-coupled nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10508">
        <property type="entry name" value="Zn-ribbon_RPB9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.10:FF:000004">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.10:FF:000009">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019761">
        <property type="entry name" value="DNA-dir_RNA_pol-M_15_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012164">
        <property type="entry name" value="Rpa12/Rpb9/Rpc10/TFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001529">
        <property type="entry name" value="Zn_ribbon_RPB9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034012">
        <property type="entry name" value="Zn_ribbon_RPB9_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001222">
        <property type="entry name" value="Znf_TFIIS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11239">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11239:SF1">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02150">
        <property type="entry name" value="Zn_ribbon_RPB9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01096">
        <property type="entry name" value="Zn_ribbon_TFIIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005586">
        <property type="entry name" value="RNApol_RpoM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00661">
        <property type="entry name" value="RPOL9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00440">
        <property type="entry name" value="ZnF_C2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57783">
        <property type="entry name" value="Zinc beta-ribbon"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01030">
        <property type="entry name" value="RNA_POL_M_15KD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00466">
        <property type="entry name" value="ZF_TFIIS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51133">
        <property type="entry name" value="ZF_TFIIS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 8 12" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="3 9 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8 12" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 9" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 10 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="TFIIS-type" evidence="13">
        <location>
            <begin position="87"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C4-type" evidence="10">
        <location>
            <begin position="22"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="22"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="25"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="44"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="124"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR005586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR005586-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR005586-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CAG5103813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="130" mass="15418" checksum="AA830BC492145C68" modified="2022-05-25" version="1">MSRLTNYDSHNDGPGFVGIRFCQECNNMLYPKEDKENKVLLYACRNCDFKQNADSNCIYVNKIMHEIDELTHIVQDVISDPTLPRTEDHPCPKCNHREAVFFQAQTRRAEEEMRLYYVCTNQHCTHRWTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HNE4</accession>
    <name>A0A8J2HNE4_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">aldehyde dehydrogenase (NAD(+))</fullName>
            <ecNumber evidence="4">1.2.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HICCMSTLAB_LOCUS10976</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.3" evidence="4"/>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5102360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HNE4"/>
    <dbReference type="OrthoDB" id="310895at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004029">
        <property type="term" value="F:aldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000029">
        <property type="entry name" value="Aldehyde dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11699">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0520">NAD</keyword>
    <keyword evidence="2 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="7">
        <location>
            <begin position="12"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="7">
        <location>
            <begin position="224"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="118"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG5102360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="309" mass="33324" checksum="2EF16569E130E37F" modified="2022-05-25" version="1" fragment="single">QWFLINGAFLIAGQITPWNAPIILLALKWGPALAVGCTVVTKPAEQTPRCTLYIAALTKEAGFPPGVVNVVPGFGPTAGAALAEHPDVAKIAFTGSVEVGKLIMKASGNSNLKRVTLELGGKSPLVIFDDVNVDKAVKIAHEAIFTNSGQICFAASRTYVHSKIYDEFVEKSKDLALKRKVGNPFDPATEQGPQVEKEIFDRALKFIEIGKKEGAKLLFINNEFVDSVSGKKFPTINPSNGAVITQVSEGDKADVDKAVAAAKQAFARGSPWRAMDASARGVFINKNLTRVDFIVELESIQVFRHHPRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HQ03</accession>
    <name>A0A8J2HQ03_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS13485</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5108849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HQ03"/>
    <dbReference type="OrthoDB" id="7694231at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="75"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5108849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="307" mass="35499" checksum="BE55D85187DEF2E3" modified="2022-05-25" version="1">MRQECPRILLMLLTDDVSKKTWLDASNGNININSINNYNNESNSKDLEVIMKKKAASIVCHTLIINAWRRRREEVIDLNGIIEQLRQQIDHLQLQIVVLRRLLDTENSRVGKLGAQVHRAKMQLDSITKEKETLTNENKKLKSDLNSINQVTEEQKITIENYKNELLSTKNQVKAVDTQIMKDREKLLKLRDDKQILLDKVQDIEKKKIEAEKFLLVSEDREKVLSLRISNLEIQLSDREAALRKIESVYRSQLTEIRDLREKLLKQSQVCGWSSRVLQIAGSVVRAPQVILRTLSFLAFGGIPSRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HQ32</accession>
    <name>A0A8J2HQ32_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS12338</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5106595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HQ32"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="128"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5106595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="147" mass="17126" checksum="56807DD1A7E992F9" modified="2022-05-25" version="1">MNRSHCPIIRLWYCQSILLRYILALQIFVKIRTHIDELSIDRQPSDDHPGLPCPRQIIFIEPGENIRLFLNFTTVTYEMAQEDETEELPTAYGVMIAVITGLLGYVLWDFYGEFGFQGRDDFELVNSVLYVIELYSNFICVPITIIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HQJ9</accession>
    <name>A0A8J2HQJ9_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Similar to ADCY10: Adenylate cyclase type 10 (Homo sapiens)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HICCMSTLAB_LOCUS12441</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5106800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="194468at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004016">
        <property type="term" value="F:adenylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16305:SF28">
        <property type="entry name" value="GUANYLATE CYCLASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16305">
        <property type="entry name" value="TESTICULAR SOLUBLE ADENYLYL CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="4">
        <location>
            <begin position="1031"/>
            <end position="1064"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="886"/>
            <end position="928"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="915"/>
            <end position="925"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAG5106800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="1484" mass="171739" checksum="D04A03D4680E8B10" modified="2022-05-25" version="1">MKKSPSYKENLWHGKDSLTSKSSSESQTIHWIPELFGPVFETEKISLCQSYRAHQGKIRTQLISTFVPDEIIYKTDLAKKSLEEFLAVILFIEISNVIKLEADEILAVWKVPKFQLAAEIVEAVIKCGLKCQKGVKNISTILQVKIKITISTGNVAFSIIGNDNFKKWVLVGQPIIEAESAANNCNPGEVIITKSTWQYVLPSDYEYLSVDSDNVKKVSILSINLTPVKIKTQEIVNLSDKCFHALYKLTEKYLGIIKTVKVYPKRIFFSVYFGFSPDKHFLHENSFICAEKYRMILSNIEDIVKLSMGISTGMVFCGVIGHTIRQSFTCTGLSCEKSKKIATVANQYSLVSRKIDKIYPIIGCFDKLEKLTDILDDICVSSRNYCGVLIEGFDSAGKSRLLDECVLIAKSRQILIYTVSLNFLNITRAYNTIYYILLEMFQIHDCYSVEERKKSLIKKIGNIIPSSKFCYLNVLFNVDFTHSSTFLSENEEQHISKTLILFDKLLGSVEKPTGIFIDDIHFMDLESWAFVTRIMNYNNFFLAMTIDNSKSISSNHYNDSRLFKFTLNGFNPKEMGILICQLLNVHAISEKIDKILNNANWMNAGWCEAFISLVLERKWFEFYFRGGKVNFQDLISPPLVSVIKVPYGVFPEEINPHLPQDKFHVLDIKSTSINSQFIRDDTYLDIETLYKKLFHKLTSYEQSVLRSAAVLGDIFTREALENVTPNSMDFHTARAITRLMDLRILECASIQRFNYNLSPYVKRNTFSDMHHLLHCSCYQTNVAVRDEQLPSYAGCKLLEFKVKAFRRFVYDQILPNKKRELHSRAAEIYERQARTCISCGGGSFLNALGVVQGIGTDARALRPSIVRRSLSRDAIYFSKFKFRRRSSSTESPNQEGIHHQKISILPTHSKDQDESQYSSDELSTPSDKRNLNKSELLLLKKNDPSRRSQLKKFNLIDFRNCDCENVLNGVFQELLWHLQHTDWSNKLVEYMMEYSAGLIFICRYCEAFNILIITKEINDKLPLEKRWKNKYIIWGLMGDASVALGNISKAKKYFKEAIRLQTNDQHYDILCVRPKIICRAWHRKINRKLINRFYKNRFSENEMSRRLVIAYHLMKLSKVLLVIYIIKRIRKIFCLQDYRESNRAELIAIDAFNIGFSSSEGFTQKCELYIKACEIFRACKYKNALEIGSKLFKISKSLHVTAVQLEILPLLINLTIRMKRIYETADLMQELYHLSNQDIDKSSITWYYALSLDLTLDAGMVLESFEQCAEYAKEIIANKNRSCVLRDPESLKRLLTCLWIWQLRSGTTVTATFAQCCASYAVNIKPDNYAQLLNLLKTFEVYFLELRRCINIKRSDELSELVQNIKLILKTLEQHLNNAGFIKPRFYILKAYFKLAHGDKHSAKSLLKKARKYASFQGNEMLLAWILLNEKMWEKLQFNNTSSYWMENVRHVDSFNWRDIHDFDVKAWSSILFFISPPDSYVKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HQS7</accession>
    <name>A0A8J2HQS7_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Similar to AP2M1: AP-2 complex subunit mu (Gallus gallus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HICCMSTLAB_LOCUS13854</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <location evidence="2">Coated pit</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the adaptor complexes medium subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5109218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HQS7"/>
    <dbReference type="OrthoDB" id="10259133at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030131">
        <property type="term" value="C:clathrin adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005905">
        <property type="term" value="C:clathrin-coated pit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd09251">
        <property type="entry name" value="AP-2_Mu2_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14836">
        <property type="entry name" value="AP2_Mu_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.60:FF:000002">
        <property type="entry name" value="AP-2 complex subunit mu, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1170:FF:000003">
        <property type="entry name" value="Putative AP-2 complex subunit mu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1170">
        <property type="entry name" value="Mu homology domain, subdomain B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050431">
        <property type="entry name" value="Adaptor_comp_med_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036168">
        <property type="entry name" value="AP2_Mu_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043532">
        <property type="entry name" value="AP2_Mu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022775">
        <property type="entry name" value="AP_mu_sigma_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001392">
        <property type="entry name" value="Clathrin_mu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018240">
        <property type="entry name" value="Clathrin_mu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028565">
        <property type="entry name" value="MHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043512">
        <property type="entry name" value="Mu2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10529">
        <property type="entry name" value="AP COMPLEX SUBUNIT MU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00928">
        <property type="entry name" value="Adap_comp_sub"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01217">
        <property type="entry name" value="Clat_adaptor_s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005992">
        <property type="entry name" value="Clathrin_mu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00314">
        <property type="entry name" value="CLATHRINADPT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49447">
        <property type="entry name" value="Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00990">
        <property type="entry name" value="CLAT_ADAPTOR_M_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00991">
        <property type="entry name" value="CLAT_ADAPTOR_M_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51072">
        <property type="entry name" value="MHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0168">Coated pit</keyword>
    <keyword evidence="5" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="10" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="domain" description="MHD" evidence="11">
        <location>
            <begin position="168"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="347"/>
        </location>
        <ligand>
            <name>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate)</name>
            <dbReference type="ChEBI" id="CHEBI:57836"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="349"/>
        </location>
        <ligand>
            <name>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate)</name>
            <dbReference type="ChEBI" id="CHEBI:57836"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="351"/>
        </location>
        <ligand>
            <name>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate)</name>
            <dbReference type="ChEBI" id="CHEBI:57836"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="360"/>
        </location>
        <ligand>
            <name>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate)</name>
            <dbReference type="ChEBI" id="CHEBI:57836"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="362"/>
        </location>
        <ligand>
            <name>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate)</name>
            <dbReference type="ChEBI" id="CHEBI:57836"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR005992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR005992-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAG5109218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="441" mass="49994" checksum="296A5D8457F6DB7F" modified="2022-05-25" version="1">MIGGLFLYNHKGEVLISRVYRDDIGRNAVDAFRVNVIHARQQVRSPVTNIARTSFFHIKRANIWLAAVTKQNVNAAMVFEFLLKINDVMQSYFGKISEENIKNNFVLIYELLDEILDFGYPQNCDTGVLKTFITQQGVKSATKEEQAQITSQVTGQIGWRREGIKYRRNELFLDVLEYVNLLMSPQGQILSAHVAGKVIMKSYLSGMPECKFGINDKIVMDSRGVKGGSGALGGEDPTGARTGKPVVVIDDCQFHQCVKLSKFETEHSISFIPPDGEFELMRYRTTKDISLPFRLIPLVREVGRTKMEVKAVLKSNFKPSLLGQKIEVRVPTPLNTAGVQLICLKGKAKYKASENAIVWKIKRMSGMKETQLSAEIDLLDTDTKKKWTRPPISMNFEVPFAPSGFKVRYLKVFESKLNYSDHDVIKWVRYIGRSGLYETRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HQY9</accession>
    <name>A0A8J2HQY9_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Similar to Acyl-CoA Delta(11) desaturase (Spodoptera littoralis)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">HICCMSTLAB_LOCUS12728</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="12">The histidine box domains are involved in binding the catalytic metal ions.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the fatty acid desaturase type 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5107396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HQY9"/>
    <dbReference type="OrthoDB" id="10260134at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004768">
        <property type="term" value="F:stearoyl-CoA 9-desaturase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006636">
        <property type="term" value="P:unsaturated fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03505">
        <property type="entry name" value="Delta9-FADS-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015876">
        <property type="entry name" value="Acyl-CoA_DS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005804">
        <property type="entry name" value="FA_desaturase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11351">
        <property type="entry name" value="ACYL-COA DESATURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11351:SF21">
        <property type="entry name" value="GH07782P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00487">
        <property type="entry name" value="FA_desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00075">
        <property type="entry name" value="FACDDSATRASE"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 12" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="8" id="KW-0408">Iron</keyword>
    <keyword evidence="3 12" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="37"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="69"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="185"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="342"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="374"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="495"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="domain" description="Fatty acid desaturase" evidence="14">
        <location>
            <begin position="69"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CAG5107396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="600" mass="71064" checksum="B292855B50E12A08" modified="2022-05-25" version="1">MYSESITLQSQPEEKDEIRLIKGKLKKKRWYEFETKILWNNAIFIIIIHVLGLYYTITFPYLDHKILTVWGIVVGFMSGIGVTGGVHRLWTHRAYKANVPLRIILAILYYTAGQNRIYNWVRDHRVHHKYTDTPADPHDTNRGFWFSHVGWLMMKKRPEVRKCGKEIDMSDIINDPVVQFFDGNYLLLNTLFTFVVPTLIPYYFFDQSLKWSFISQGLIRYPMVLNATWAVNSFAHMFGYHTYDKSITPAENMWVSFVAGGEGSHSFHHVFPWDYKASEFKSVFFNATTCWIDMFAQIGWAYDLRTVSPEHIKRTVQRRGDEIVENKKELTKKRWYEFETEVVWSNVIIITFLHVMALYYLFAYPYWKYKILTVWGIVVGTMGGIGVTGGAHRLWTHRAYKAKTPLRIILAILFYTAGQNKIFDWVRDHRVHHKFTETPADPHDSKRGFWFSHVGWLMLKKRPEVIEKGNLIDMSDILNDPVVQFFDRHHMKLKLLFNMIIPVFIPIYFFNQSFKWSFITQVFIRYPWSLNFTWSHVFPWDYKAAEFKSVLFNTTTCWIDLFAKIGWAYDLRTVSPEHIKRVVERKGDGTHPKYSCLSKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HSH6</accession>
    <name>A0A8J2HSH6_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Similar to CDC16: Cell division cycle protein 16 homolog (Homo sapiens)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HICCMSTLAB_LOCUS13685</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5109049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HSH6"/>
    <dbReference type="OrthoDB" id="10006270at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045842">
        <property type="term" value="P:positive regulation of mitotic metaphase/anaphase transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12558">
        <property type="entry name" value="CELL DIVISION CYCLE 16,23,27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12558:SF9">
        <property type="entry name" value="CELL DIVISION CYCLE PROTEIN 16 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12895">
        <property type="entry name" value="ANAPC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00515">
        <property type="entry name" value="TPR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81901">
        <property type="entry name" value="HCP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1 9" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-0498">Mitosis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 7" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="repeat" description="TPR" evidence="7">
        <location>
            <begin position="468"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="7">
        <location>
            <begin position="502"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="574"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="578"/>
            <end position="594"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAG5109049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="619" mass="70209" checksum="E34B3976C8526A2F" modified="2022-05-25" version="1">MSRLESDIDCNGMQNLSDSKNINLDNFRKLVKSYIDAHLYSAALFWADKVVSLGNEEPRDICTLGQCMYLMKQYHRAAHLIKSRGLEKTDPMCHYLTIRSLLEAKEFTEALQIINETELCTSISQTGVSFMDHTNFMQDAPKNVQSAIFYVKGRVHEATDNRSVAADCYKQALLCDVYSYQAFEALVQNQMLSAAEEKELLDTLPFNEQCSEADRELLKMLYESKLKKYQAPLEDLSITCVKGVLVTDRLQENLDMQVAKAERLYYNCDYQQCFSLTEVILKKDPYHSCCLPVHIACLVELKKTNALFYLAHKLVDLYPDMALAWFAVGCYYFAIGKSDHARRYLAKSTALDRLFGPAWLAYGHSFAVENEHDQAMAAYFKASQLMKGCHLPLLYIGLECGLTNNLKLADKFFQQAQSIAPNDPFVIHETGVISFSNLDYKTAERQFKEALSKIQIGGKNIVLPSKWEPLLNNLGHTCRKLKKYEEALDYHQQALVLNPLNPSTYSAIGFIHALIGNTQEAVDAFHRALGLRRDDTFTTTMLGYVLEQLIDETGTASTQEQEIEKLRVNLFSSWGDDNTGKSEENPPRPAERPSDVNYSSGEMDSEIEMLDSSTAHIEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HSP3</accession>
    <name>A0A8J2HSP3_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Similar to ZXDB: Zinc finger X-linked protein ZXDB (Homo sapiens)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HICCMSTLAB_LOCUS12617</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5107174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HSP3"/>
    <dbReference type="OrthoDB" id="6277246at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000007">
        <property type="entry name" value="Basic krueppel-like factor 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235">
        <property type="entry name" value="KRUEPPEL-LIKE TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235:SF120">
        <property type="entry name" value="KRUPPEL-LIKE FACTOR 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="5">
        <location>
            <begin position="516"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="5">
        <location>
            <begin position="546"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="5">
        <location>
            <begin position="576"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="5">
        <location>
            <begin position="606"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="5">
        <location>
            <begin position="637"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="5">
        <location>
            <begin position="668"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="5">
        <location>
            <begin position="698"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="5">
        <location>
            <begin position="728"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="5">
        <location>
            <begin position="758"/>
            <end position="785"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAG5107174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="1049" mass="118715" checksum="DA91060A3FA2031F" modified="2022-05-25" version="1">MSRDAREDVVFTSIKSNLISGINQYHREIINVEKIFQFPAVSADIDKDLTYQVTTNLHQLTSNYYYCYNNKPKKDFNRIKPSVDEGAINLMEWSSFDQTSSCPALSHDLLTQDKHDDSDQQTPVQDDTGMETVDDIEKWLETCTDNSPAISIKEMDPIKCQQLEVVDTYLGDEMPHAFMEKDSLSIDIDLTDKKLSHSLGYDPILEELQSEKFLEVCEKDGFTMPEFQLDQLEPLTLDPNDMMVAGEMLPSTSINNPSTTLAINGHQDIYTDDIKKVSCIDTDDICENTSQVYDLNDKFSEDDGANVENIVHIINESDLNDYEEERDSDDGNIDIGEENKILDDIETVDAAMIDTVDASLSNADDNMFKECKAISLLSESHKVSDKVEAGDVTEQFVGQEVQEQDQEKSKEEIMAVVAISTDKRSNMTQIVINTGKGEQIYRGKTSELMEATGYFSKSPKIKTNLSNNTVEINHTEVPLSGSLSNQEAIISKALEELGFSEENLMSVTMPDNGKMWICPREDCRREFNRLYALKGHILAHYGVRPFKCDQEGCTWAFHSEFKLKRHKETHLKRKDYVCQVEGCNKRFTTVYNLWTHEKLHTRPNRIACQVPECEEKFQTKRALELHMKTHDQSHAPYVCMHEGCGKRYYSSNALTSHQRCHSYKEADIKCSWLGCGKIFDKPCRLKAHLRSHTGSKPYLCTFAGCSWAFTSSSKLKRHEKKHTNDRKFICDVTGCNKAFMRSEHLKEHKLTHSEGRYFQCYICEASFSAKSSLYVHIKKHQNKIAPEYAPESIQPLDTKLTFTNGDNNFCHSLPIDLESEMVDNDVLQESFIPEKYVNSSSDSVMIDNKTVVSEIITAKPKFTCPINNCTRTYMKKVSLKSHIVKFHGYSIEDNELSQSSETDYVLCANNTSVSNKVETTRRINVNADGDIDIVDTVAEITCLPEPKPPPTNEKLLKNINNRGTEASNHGSARTGLTCADILKIKRDKNESFDDSVIGASDVVLGTADLAESLLLPDELSSMYFHDDMGSECQILLLDSTTADSETTAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HT99</accession>
    <name>A0A8J2HT99_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS12964</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5107891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HT99"/>
    <dbReference type="OrthoDB" id="8191090at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.15.10.30">
        <property type="entry name" value="Haemolymph juvenile hormone binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010562">
        <property type="entry name" value="Haemolymph_juvenile_hormone-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038606">
        <property type="entry name" value="To_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11008">
        <property type="entry name" value="PROTEIN TAKEOUT-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11008:SF41">
        <property type="entry name" value="RE70318P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06585">
        <property type="entry name" value="JHBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035195782" evidence="2">
        <location>
            <begin position="19"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="123"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="309"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="156"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="212"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="239"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="264"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="310"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5107891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="627" mass="72645" checksum="E0947F553B5DFF08" modified="2022-05-25" version="1">MRLIVLYLLIALISKASCATSLLEMSQNLWSKFLNGGLANIGPLDPLRIPMVKVDQSQNRTNYRIILKNIEIAGLNQSTLESIHIGKGSVKSNLSEHEAGYVSYSDRNVIDSIRYRFHTVVKEPKTQDSEELRVQPIETFEESESENRYANDQSQRRYNSQQSQQRYANGQQRFNNDQQNQQRYSNNQQNQQRYSNNQQNQQRYNDERFTNQQHQQNSEQQPQRTQGSQYQEGFDNRRSQSNSDRYNNNYRGNQQPQYQSRPQENVRPKESQSHGRDQELYLVYAQSQANYENQRRVQQDQDPRVHQHQSFVTESNVETQKSFTNKGSPTRFSLNLKARPPCVHEEKDAETFNVKDRNGESQRLENQPGYVDIVYADQNSNKERHFGNLRIEPKKDRIVYRLSDLMKDLDSHRKFIIHNFTESELLLKRNDGVRTAEESKRIKDLIRYAKDFQEEQGYFEEGMEITYHFGNETEPKVFDGKRTKRAHEDENEDDIIHVIMKIHAPLIKVKSGYVLMGSVGKQVLRGDGVLNAQFTDVTGEFTVELKKTGNTTMIVRAARARLQANSKNVTFQGMDENGPVEEILTQGLLAAEAVAAMLADDLATKALNDTVTDAIIYKMYKELPNNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HTJ4</accession>
    <name>A0A8J2HTJ4_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS13164</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5108291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HTJ4"/>
    <dbReference type="OrthoDB" id="8176390at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="199"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="200"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5108291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="318" mass="36140" checksum="52DC0858F3A81940" modified="2022-05-25" version="1">MTGKNQEPTDNQSDATKIKIITEKIKSLEDNVTKVRKEVSNCFEDLKNSIMAREKQLLRQIEAIHNQQLSIIQSDWKLVNSIPAIGVDLVNDCKDISLSIIKLGKIEFPDSKDNLIVKNIEPYSIHEYEDDKKDHITFDKSIQVNENYDNIIIKLSDVTFSNVSKTDNSSDSILKSKINLSSQLSLDYKTDNDCSPLCSKNNNNNNNNNNNNVDDDDDDNLINISGDNNNNNKTINSTLNVYSELQIASHNHLPQQTIVIDSNNSIENKQITDEHPKQIQQWLQQILIESETEPSIQEIGNFTDEISKFRCSESLVET</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HTL7</accession>
    <name>A0A8J2HTL7_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Peroxiredoxin-5</fullName>
            <ecNumber evidence="9">1.11.1.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HICCMSTLAB_LOCUS13241</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 9">
            <text>a hydroperoxide + [thioredoxin]-dithiol = an alcohol + [thioredoxin]-disulfide + H2O</text>
            <dbReference type="Rhea" id="RHEA:62620"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:35924"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="EC" id="1.11.1.24"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the peroxiredoxin family. Prx5 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.24" evidence="9"/>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5108446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HTL7"/>
    <dbReference type="OrthoDB" id="1882547at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008379">
        <property type="term" value="F:thioredoxin peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03013">
        <property type="entry name" value="PRX5_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000020">
        <property type="entry name" value="Peroxiredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037944">
        <property type="entry name" value="PRX5-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013740">
        <property type="entry name" value="Redoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10430">
        <property type="entry name" value="PEROXIREDOXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10430:SF16">
        <property type="entry name" value="PEROXIREDOXIN-5, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08534">
        <property type="entry name" value="Redoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3 9" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="6 9" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="10">
        <location>
            <begin position="33"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="active site" description="Cysteine sulfenic acid (-SOH) intermediate" evidence="8">
        <location>
            <position position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR637944-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU366011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAG5108446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="186" mass="19763" checksum="7F807F583591CDA1" modified="2022-05-25" version="1">MTQYISRAIAIVGRSSLSCVKRGFHVSPRAMVISVGDKLPSVDLYEDAPSNKVNSAELVSGKKIIIFGVPGAFTPGCSKTHLPGYVTKADELKSKGIDEIACVSVNDPFVMSAWGKDQGAAGKVRMLADTNAEFTKALDVAMDLAVLGGTRSKRYSLVVEDGIVKEVNIEPDNTGLSCSLADRIKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HU23</accession>
    <name>A0A8J2HU23_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS13542</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5108906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HU23"/>
    <dbReference type="OrthoDB" id="7682945at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="253"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="94"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5108906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="426" mass="47442" checksum="C0EB5B657085D07F" modified="2022-05-25" version="1">MSLLQIIIPTILSVQFIQIDSKSLDNPLTLKNLQLTAPSFQPKVNFSSPISVKQSMTVGAIKPIGQNRHGKFFYSPSFLTGLGIGSLASSAALSSSPPMLSPNSEPLSRRNSRPMNMFMDTNQSLPRPQISMPPHSLNPYDANYPYFALSTSLFDHSLRSIYSLLENLKNQLANRETSKEPTRVTVKNLNDEINNSAEETSNVKIVSKDDGSHFGVVDRTILKDVIKESIEEINKDLEQRQVVNIRATKNNTNITATNEQNQTENTSTNSPVTAPTPISTTESPIITSSKPEYHGGNPQPIHNVNLINGFPSTEYGHPHNEIHYGPPPSIFDHGNINGYGHDHLFAQNHLHDHGFAQTHPHEHEVFNPNYYHSEPYYGAPENHSPTDFFPSPTAENWPVYPPHARAFKVSSKTIPKTNIFRPSKLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MA08</accession>
    <name>A0A8J2MA08_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Haem peroxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HICCMSTLAB_LOCUS2544</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001117">
        <property type="protein sequence ID" value="CAG5077735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MA08"/>
    <dbReference type="OrthoDB" id="823504at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022412">
        <property type="term" value="P:cellular process involved in reproduction in multicellular organism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09823">
        <property type="entry name" value="peroxinectin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.640.10:FF:000003">
        <property type="entry name" value="chorion peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.640.10">
        <property type="entry name" value="Haem peroxidase domain superfamily, animal type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019791">
        <property type="entry name" value="Haem_peroxidase_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010255">
        <property type="entry name" value="Haem_peroxidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037120">
        <property type="entry name" value="Haem_peroxidase_sf_animal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11475:SF141">
        <property type="entry name" value="CARDINAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11475">
        <property type="entry name" value="OXIDASE/PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03098">
        <property type="entry name" value="An_peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00457">
        <property type="entry name" value="ANPEROXIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48113">
        <property type="entry name" value="Heme-dependent peroxidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50292">
        <property type="entry name" value="PEROXIDASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 8" id="KW-0349">Heme</keyword>
    <keyword evidence="7 8" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3 10" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="34"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="520"/>
        </location>
        <ligand>
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR619791-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAG5077735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="776" mass="86788" checksum="D8B66C6518ABEC37" modified="2022-05-25" version="1">MSASETTFLTHSNESAYHKCRRVIRNQATKFRQFQFCLCAIILLVLIMILVAVVSYSLNEIHLNEEISQKNGTFTLKLSMSPNFIPSYHDLSDQELSEMIKAGQLAIIHRHYLDSQATFHPLDEVSPNTRHQNAVKTSLFAGKLALAGVGELGATRYFQSIRKDTDIISRDIYFDGNWAPSGSSCSEYYISRCHDTSKYRTYDGTCNHPENRGAAFTPFSRSLPPDYADGIEAPRVAKSGKALPSARMISLLAHRPVSSSNPSFTVMLAVFGQFLDHDITATALSQGTNGSSLSCCPPDNLEHPECFPVFVGPGDPVYDVAGSKCMEFVRSAPAMQCKLGPRQQLTQVSAFIDGSTIYGSDKSIADSLRDFKDGQLKMYRLANGRTLLPQSTDFNDGCNREVENKRGRYCFLSGDARANENLHLTTMHLLWARQHNFIASELQKINPHWDDERLYQESRRIVGAQMQHITYREFVPVIIGKSETHKRKLVPLESNTYRESSGGDPAIANNFASAAFRFAHTLLPGLMKMTDAEKGTADYIQLHKILFNPYSLYGASGVKSAIISATTNFIQKTSTHVSSQLTRHLFEDPLSNTNYSYNSTHHLPFVPCGLDLVSLNIQRGRDHGLPGYTAWREYCGLIRPRNFLQLKGIVDSDSFEQLPLLYEDVDDVDLYTGALAEIRMSDGLIGPTFTCLISQQFQRLQSGDRYWYESSQSPYPFTPDQLVQLRRSSLAKLICDCSDDIDEIQPLVMQSAGDGNPITLCDDIEAVDFSAWKEAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MAB1</accession>
    <name>A0A8J2MAB1_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Similar to GABBR2: Gamma-aminobutyric acid type B receptor subunit 2 (Homo sapiens)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HICCMSTLAB_LOCUS2712</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001117">
        <property type="protein sequence ID" value="CAG5078341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MAB1"/>
    <dbReference type="OrthoDB" id="2150267at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038039">
        <property type="term" value="C:G protein-coupled receptor heterodimeric complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004965">
        <property type="term" value="F:G protein-coupled GABA receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007214">
        <property type="term" value="P:gamma-aminobutyric acid signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002455">
        <property type="entry name" value="GPCR3_GABA-B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017978">
        <property type="entry name" value="GPCR_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017979">
        <property type="entry name" value="GPCR_3_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10519">
        <property type="entry name" value="GABA-B RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10519:SF74">
        <property type="entry name" value="GAMMA-AMINOBUTYRIC ACID TYPE B RECEPTOR SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00003">
        <property type="entry name" value="7tm_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01177">
        <property type="entry name" value="GABAB1RECPTR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01176">
        <property type="entry name" value="GABABRECEPTR"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00981">
        <property type="entry name" value="G_PROTEIN_RECEP_F3_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50259">
        <property type="entry name" value="G_PROTEIN_RECEP_F3_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 13" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="15"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="93"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="151"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="192"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="216"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 3 profile" evidence="12">
        <location>
            <begin position="1"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="398"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="486"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="674"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="412"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="486"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="708"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="719"/>
            <end position="739"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAG5078341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="911" mass="100287" checksum="3B7BD0C6ECD2528F" modified="2022-05-25" version="1">MAVDARYIKMSSPHLNNLIIVGCMLTYSSVIFLGLDSTLSSVQAFPYICTARAWLLMAGFSLAFGAMFSKTWRVHSIFTDVKLNKKVIKDYQLFMVVGVLLVIDLAIMTTWQVADPFYRETKQMEPYPHPSSDDIVMIPENEYCQSNRMTIYLGCIYAYKGLLMIFGAFLAWETRHVSIPALNDSKYVGMSVYNVVIMCVTGAAISFVLADKQDTMFIMLSIFIIFCSTATICLVFVPKLIELRRNPQGAIDKRIRATLRPSSKTRRDSTVSELEERLKDVTTANQKFRKQLLEKESELQMYLSKLGDEDLLRDTKEAMDRLSVPRNETLIKKEGVSMVTETTDVSISLCSLNSTTVSQPESEYVNVIASSNQPTARKRASFGKVTIDNERTTLLPQAMSSPTTNHYKKSPNNNNTINNNNKNNNINNTENQETEPLLIKRSPEPRIMTTNVNGDKKSSALTVTSVSLPTTTSILTSTSVALKKSGEFAEEPLGHEKTKDTSVEKRAKLPTPPPPTKNVSFGELREDNYLEQAILPPPVQFVPKHRHTPHHHQTLAKRRSSVKNNGLAHSHHELFEKRRTSVPANSISYISTENISKVDALNDESLSSFDRTYVIGECGHRRAALGGGTGYRCEKHGGGRLLHTHHISNGSADISGTNTRVVSKHHRDRDNLQYCKNASSPSVPAMLNASYSDTEKTEDPSAIIQRSVSEKSREKCSRSRTSTAGTSTTLTASSGHHLTAGPVECRHRTQPRKHRECRHTESRLRQQARLEYVQSSPNVATTVHSGKFASANPRGGGITTSCGRGAINCGHSGLGDSLGLGMGGSGSAMGGSELVVRDETTSNPDGVASGSTANLTNMCSAASDGELLDREILPIFQKLLSERHKSTGGAYGSNIASCPNISIKCDIVEYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MCA3</accession>
    <name>A0A8J2MCA3_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Similar to ZNF500: Zinc finger protein 500 (Homo sapiens)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">HICCMSTLAB_LOCUS3804</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5083321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MCA3"/>
    <dbReference type="OrthoDB" id="3437960at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008170">
        <property type="term" value="F:N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008276">
        <property type="term" value="F:protein methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10534">
        <property type="entry name" value="PR-SET_PRDM-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000450">
        <property type="entry name" value="PR domain zinc finger protein 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000100">
        <property type="entry name" value="Zinc finger 45-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000557">
        <property type="entry name" value="zinc finger and SCAN domain-containing protein 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000770">
        <property type="entry name" value="zinc finger protein 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000761">
        <property type="entry name" value="Zinc finger protein 449"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050331">
        <property type="entry name" value="Zinc_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515:SF49">
        <property type="entry name" value="GASTRULA ZINC FINGER PROTEIN XLCGF49.1-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515">
        <property type="entry name" value="PR DOMAIN ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21549">
        <property type="entry name" value="PRDM2_PR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13912">
        <property type="entry name" value="zf-C2H2_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="236"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="264"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="292"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="335"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="363"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="189"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CAG5083321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="399" mass="45726" checksum="28083BAF87E10D07" modified="2022-05-25" version="1">METCVLIPREFSLALATDHDRNSCSEIFKTEARSFSADVRISVWSNVFIPSETLIYPFQGSIRFDKIDLYSLLDDNDIRREYGCYDEVSFSNYNLNKRQCNWIRFLRIVQSYSDQVNLIGTKVKGDPIFEVIKDVEPDSELVAWFLPASHEDLVFISRDFCSRSAIYRCTIDSILADLSKTLLSHQNSSPVRTSYYEPDEYESTSEESSSSTLSLTSDHLDCSIVTTIKRGERVLLPCEVCGKSFDRPSLLKRHMRTHTGEKPHICMVCNKGFSTSSSLNTHKRIHSGEKPHQCLVCGKKFTASSNLYYHRMTHIKVKLHLRVISVTPTSQEKPHKCSQCSKSFPTPGDLKSHMYVHNGLWPFRCHICNRGFSKPTNLKNHMLLHLGRCSNKKFIKADL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MG15</accession>
    <name>A0A8J2MG15_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Olfactory receptor 206</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HICCMSTLAB_LOCUS2472</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001117">
        <property type="protein sequence ID" value="CAG5077480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MG15"/>
    <dbReference type="OrthoDB" id="6604226at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005549">
        <property type="term" value="F:odorant binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004984">
        <property type="term" value="F:olfactory receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004117">
        <property type="entry name" value="7tm6_olfct_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21137">
        <property type="entry name" value="ODORANT RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21137:SF35">
        <property type="entry name" value="ODORANT RECEPTOR 19A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02949">
        <property type="entry name" value="7tm_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0552">Olfaction</keyword>
    <keyword evidence="8 11" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="9" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="40"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="80"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="130"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="193"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="273"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="306"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAG5077480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="404" mass="46252" checksum="3C4765C0DFA00BE6" modified="2022-05-25" version="1" fragment="single">MDYKNREPTKWNSDTTYALGPYKLLTRSIGIWPLDHFGKVIILQVFLNSFIQCLVIIIFIDDLITKGNCGLITDTVDALSLIATSILSVCKIILPLVYKKRMYFIVNSAIEDWANVRDKKSKTIMLKYAFAGRIVFIIQMIGAYMTIVPLIFGNPPTIHKFSSDPLSDNATMLRNIPIGPNCWVSTSISMSIYFAYYGLVTVHLVILCTAYIGGDVYIFGIAMHVCGQFKLLYTDMESLDGKKNFFSLRKQINQLSQRHTYLIKLANEFERTFNLIILLQVAANTFIIGISGILLLWGLKTGNSEIIIAALIRIYLLFFQLYIYSFIGESLSTQTRNLQLAIYNCKWYEMSPILAKDLLFIIMRTNYPFHLTAGKICNMNISSFKDLVKMMFSYFSIIRLMFEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MG49</accession>
    <name>A0A8J2MG49_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similar to tsl: Torso-like protein (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS2532</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001117">
        <property type="protein sequence ID" value="CAG5077688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MG49"/>
    <dbReference type="OrthoDB" id="10060229at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035217153" evidence="1">
        <location>
            <begin position="22"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5077688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="339" mass="39577" checksum="C9844BAD74DA4E0D" modified="2022-05-25" version="1">MFKHKSVVLLTITLMIVFATSELNVVPIVGNSLNILKFHGILSLTMRVFSSDSEWIFRQPSTKVFKQVTTAARFTKNSPVFSGDFHIEMCENYEQLFQAYFRNFTIEGVGKPWRSFMASWEKNRIAKYFGIRESLLSEEYKYIFVRIARVRDNLKMTTPPESLEIEESILDEADNVDIEDSVSTVNFIYKYSGTHYIESYTSGDSLFQVFVYRPKPFKFIKRAFTTRGIDILFEKAVTNYFSTDFAEYVGELKTGSGNETVEEWASINLFFAHQDPESQNILRLYGNERLLTRLGNLLWNEALIQLNLKYVSPFFPDKEFSKWLLEFISNNLKLWDDNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MHI8</accession>
    <name>A0A8J2MHI8_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS3292</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5081465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MHI8"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5081465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="94" mass="11447" checksum="B3701AA23F59E071" modified="2022-05-25" version="1">MRPLAEYYIVKDNVIDAKILAIRCKCQPLNEYLWNLHVSTLIHKFRFPKENMISNEEIMRWDSLRSLGWNIHYLEEEVKERGYELWDLYESQGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MIV7</accession>
    <name>A0A8J2MIV7_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to tipE: Protein tipE (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS7135</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5093809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MIV7"/>
    <dbReference type="OrthoDB" id="8190202at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017080">
        <property type="term" value="F:sodium channel regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002028">
        <property type="term" value="P:regulation of sodium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031578">
        <property type="entry name" value="TipE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12335:SF6">
        <property type="entry name" value="PROTEIN TIPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12335">
        <property type="entry name" value="TIPE PROTEIN TEMPERATURE-INDUCED PARALYTIC E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16972">
        <property type="entry name" value="TipE"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="13"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="231"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="267"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5093809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="355" mass="39614" checksum="8C88687E5D20E998" modified="2022-05-25" version="1">MADEKDQTFLEKLLFYTTAFFILLGTFSLFAFLFLVPFVIDPAFTTIFMDFDTRPAECVTIDVESRRGASNCSWTSCREGCTKELYDCTQIRVNYKLPVNETQLDGTDREGRAGGGVEGDEAGYKSRYERSPRDYNNYIEDFDDEFDEDDIDNRLPKPFPTGLMGNDSEWYFTGAKLFPNVKGCGYPPILNCSIFYKQYTKIGHNFSCYYSKIDPGIVLSDLDMWQVYMNLVLAMAIPIPSFIISVIYLTFAYFKIYNEDEQNLVDKNSEGGDSGVVGDNENATPFPPTSGAVTPGSEAFREDLASFGHQLKVAMADEVSRESLDGIPNSVSTQGNLSKMMTTSILTPAGPTAAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MJL4</accession>
    <name>A0A8J2MJL4_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Mitochondrial (Rattus norvegicus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HICCMSTLAB_LOCUS5534</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="3">Required for the function of coenzyme Q in the respiratory chain. May serve as a chaperone or may be involved in the transport of Q6 from its site of synthesis to the catalytic sites of the respiratory complexes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Interacts with coenzyme Q.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the COQ10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5090209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MJL4"/>
    <dbReference type="OrthoDB" id="292693at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048039">
        <property type="term" value="F:ubiquinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045333">
        <property type="term" value="P:cellular respiration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07813">
        <property type="entry name" value="COQ10p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044996">
        <property type="entry name" value="COQ10-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005031">
        <property type="entry name" value="COQ10_START"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12901:SF10">
        <property type="entry name" value="COENZYME Q-BINDING PROTEIN COQ10, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12901">
        <property type="entry name" value="SPERM PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03364">
        <property type="entry name" value="Polyketide_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Coenzyme Q-binding protein COQ10 START" evidence="4">
        <location>
            <begin position="45"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAG5090209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="194" mass="23017" checksum="BBAF40777FB58955" modified="2022-05-25" version="1">MYSYRSIFFNKNLFNCVKRHRLDFKNLYSTWDKDRTKEYEGRKLIGFSMEQIFDVVADVQKYKNFLPFCKKSEVYSRSEDSLRANLVIGFPPLLNENYTSCVTMHRPYFVKAECKDGKLFNHLNTLWIFSPGLKNNSNTCVIDFSLSFEFKSLLHSHLSNLVFNEIVRQMENAFINEAHRRHGKPCIKTVRLEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MJN8</accession>
    <name>A0A8J2MJN8_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS5594</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5090342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MJN8"/>
    <dbReference type="OrthoDB" id="7676617at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="442"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="610"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5090342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="610" mass="70541" checksum="95AE2517488C99E3" modified="2022-05-25" version="1" fragment="single">VPFEGSQGISYIGDIKGSDFNWTESLEVDLIIDGLSQIFDENFHNLTIRNVKSVNYLRSGMQRVGKSLVNSIQYFLSYLGLFRSNNKLVSAVHKLTNYEIRSATIKDEVLRQYLSLAYLIPLHSEISTRINRHFLRSNYPSKGYARSNFDLVKDSSDNGDSWTFKWLNLIGKFYDFLANAFDCLDSGKWYDVKKAFQDLMKYRMNAVKKIITQRLQRPIPNHPKINGVVFTDHQAFICDIIVRDLKSDFRNCLLQVRAIDACSKKNAAPLSSGRSQAKVSNILEKSMHSSIGSDCIVKKSNESMTTFCRNGLKSNLTKSLILLFSQSNQNRLYNSPSLEYMMDYVSRAVVKNKLIFNAFKNFLGMKSIFKPRAYGAHSKKLRNHLSEVILRLIGRVHVMNTKIGKKLVEVSEDPKKVLSKNFGTMRCITKWIDKLLNRTRHQSLTRKSRHDKNVDAENGEGNPLRYHEKSIRELVVSMRSLSELNLRKSSTIFTLANTFLLATVFYECISILVTLMYHGDNSHSSHADHNHNYHHDEGNYDTNPVTTEQITVIDDNYGEYEQFEQPGNRIHRREIGEQYDNFSSVRDLMNDDTKKFNYFYFNDIVKEYYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MK49</accession>
    <name>A0A8J2MK49_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS5066</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5089011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MK49"/>
    <dbReference type="OrthoDB" id="7676486at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5089011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="478" mass="54443" checksum="2D0BF3F704B5A054" modified="2022-05-25" version="1">MNIGEKMNNIKTAFDKLLEEDQEYFEFVDNESLCTTCKLEIDDQNFNSVAVKQEKSIHFDENIYSHSLDDIDNCKELQKATRSLSRISLEQNDLKLTDDITNLEQTNHQVIINDNNDAVIVDNPLFNYSPSFVCTGVDKALTILEQNLEDSNVKKTRAVTSQKNDPLHKNDPAVVNDKKLFLSDKETQTDLANGSSQQDNLWVDNEFLSDKELEKIDLLVNEHSNGDVNKNNHNKRKCDAGVENSAKKIKLGAREWNKDDWDSIMSDILKREKKCLDCSNDLFEYSEYLNETRKAFIRKIPSTNIKIPTPPVLVGYDNQFDFKNGKRYGQLPIQKIKIDNNNSSKLNGVNGIQSSTNTKSKIYPQKIVTPNQGPVPKSRVQLTKNNLYKINNQVNSTPKNTLRQSTIKEAFAINKENHNKGLNNVKSSNNTNTNCNNTKSLEKTFNGDAGKDNISDSSSMYNFNPFRRKINAQKKIIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MKZ0</accession>
    <name>A0A8J2MKZ0_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Similar to Tubulin alpha-8 chain (Gallus gallus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HICCMSTLAB_LOCUS3748</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the tubulin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5083155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MKZ0"/>
    <dbReference type="OrthoDB" id="6073114at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.600:FF:000005">
        <property type="entry name" value="Tubulin alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.600">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008280">
        <property type="entry name" value="Tub_FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000217">
        <property type="entry name" value="Tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023123">
        <property type="entry name" value="Tubulin_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11588">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55307">
        <property type="entry name" value="Tubulin C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0493">Microtubule</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="124"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="130"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG5083155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="236" mass="26764" checksum="3CBA3B3FF1E943BA" modified="2022-05-25" version="1">MRWDICDNNCEECQSFIADLETARSILINHISQNEGCAVQDVKNSMINDRLNYAKRVNLKVFQLKGDMCEKAQRLNYEVSAYYDATVNFSNYRKEPAQPPVQQEYKFGTLPTYSLPSNHLRPSYFRGEGLPQPTSSSLSLKSPTPASSHQLSYLVEISPKYNVLSNTTAIAEAWARLDHKFDLIMYAKRAFVHWYVGEGMEEGDEFSEAREDLAALEKDYEEVGMDSAEGEGEGAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MLN2</accession>
    <name>A0A8J2MLN2_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS7333</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5094007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MLN2"/>
    <dbReference type="OrthoDB" id="10044343at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="125"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="129"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="152"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5094007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="180" mass="19664" checksum="1323DDC29ED2F2EE" modified="2022-05-25" version="1" fragment="single">MNNNKNFLFQSHQEEESDPDQDEESGEELPQQPLQNNTHLSDNTSGNIGGAPLPVPSHIGNFLNPHFLSKLKQEPSDVDMMNSKSNLDAIHAAMTNGYPGFPFPAPFLQLQHLNPGQNRDAAAGNALVSSASSHSSESSQSSSRNNNDPRDNGQSNMNNNNSANSSQQPSSWSFEEQFKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MNQ8</accession>
    <name>A0A8J2MNQ8_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Similar to Lcp1: Plastin-2 (Mus musculus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HICCMSTLAB_LOCUS7376</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5094050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MNQ8"/>
    <dbReference type="OrthoDB" id="431378at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005884">
        <property type="term" value="C:actin filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032432">
        <property type="term" value="C:actin filament bundle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051017">
        <property type="term" value="P:actin filament bundle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051639">
        <property type="term" value="P:actin filament network formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21292">
        <property type="entry name" value="CH_PLS_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21295">
        <property type="entry name" value="CH_PLS_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21298">
        <property type="entry name" value="CH_PLS_rpt3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21301">
        <property type="entry name" value="CH_PLS_rpt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000042">
        <property type="entry name" value="Fimbrin, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000031">
        <property type="entry name" value="Fimbrin-2 like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000263">
        <property type="entry name" value="plastin-1 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000066">
        <property type="entry name" value="plastin-1 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000010">
        <property type="entry name" value="Plastin-3 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001589">
        <property type="entry name" value="Actinin_actin-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039959">
        <property type="entry name" value="Fimbrin/Plastin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19961:SF18">
        <property type="entry name" value="FI19014P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19961">
        <property type="entry name" value="FIMBRIN/PLASTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00033">
        <property type="entry name" value="CH"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00019">
        <property type="entry name" value="ACTININ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00020">
        <property type="entry name" value="ACTININ_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="7">
        <location>
            <begin position="14"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="domain" description="Calponin-homology (CH)" evidence="6">
        <location>
            <begin position="125"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="Calponin-homology (CH)" evidence="6">
        <location>
            <begin position="269"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="domain" description="Calponin-homology (CH)" evidence="6">
        <location>
            <begin position="392"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="domain" description="Calponin-homology (CH)" evidence="6">
        <location>
            <begin position="513"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="636"/>
            <end position="656"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG5094050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="656" mass="73770" checksum="AC91A9DEEA9B1A17" modified="2022-05-25" version="1">MEMLKMKKWNVIDEYLKDFPSFFKLIDENGDGFIDVKELRSALDICGFKMPGYKVRQMIEEYDDKQQFQHKGRLSFDEFEKLCKELKANELGSTFKQVVSKKENLETLGGISEASSEGTTHSVRLEEQLAFSDWINTNLGSDPDLKHLLPIDPEGRLLYDKVKDGILLCKIINHSCPDTIDERTINKEKLTLYKKHENLTLALSSAQSIGCNIVNIDAHDLTAGRNHLVLGLLWQIIRIGLFNQITLENCPGLATLLQHGEKIEDLLKLSPEAILLRWVNHHLENAGVARRCNNFQSDITDSEVYTYLIKQIAPSGTGVTLEALMEPNHVTRAEIMLQQAAKLGCRSFVTPNDVVNGIYKLNLAFVANMFNNYPGLDKPAENIEDLGSLEETREEKTYRNWMNSMGVSPHVNWLYSDLADGLVIFQLYDIIKPGTVNWPKVHTKFSKLRKFMEKLENCNYAVDLGKKMNFSLVGIAGQDINDGNATLTLALIWQLMRSYTLSVLSGLVGNSGKTVEKEIVQWVNSKLQAAGKTSSIKSFQDDVISTGRPVLDLIDAIKPGIVNYDLVKTSETEEDNLDNAKYAISLARKCGARVYALPEDITEVKQKMVMTVFVCLMATDYVPNMDSKQNNVTQNNVNNVNNVNNTNNVNNVNGQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MPB8</accession>
    <name>A0A8J2MPB8_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Similar to Exosc2: Exosome complex component RRP4 (Mus musculus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HICCMSTLAB_LOCUS7757</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RRP4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5095535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MPB8"/>
    <dbReference type="OrthoDB" id="1650at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000177">
        <property type="term" value="C:cytoplasmic exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071034">
        <property type="term" value="P:CUT catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000467">
        <property type="term" value="P:exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071035">
        <property type="term" value="P:nuclear polyadenylation-dependent rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071051">
        <property type="term" value="P:poly(A)-dependent snoRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071038">
        <property type="term" value="P:TRAMP-dependent tRNA surveillance pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034475">
        <property type="term" value="P:U4 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22525">
        <property type="entry name" value="KH-I_Rrp4_eukar"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05789">
        <property type="entry name" value="S1_Rrp4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025721">
        <property type="entry name" value="Exosome_cplx_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026699">
        <property type="entry name" value="Exosome_RNA_bind1/RRP40/RRP4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048565">
        <property type="entry name" value="S1_RRP4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21321:SF4">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT RRP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21321">
        <property type="entry name" value="PNAS-3 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14382">
        <property type="entry name" value="ECR1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15985">
        <property type="entry name" value="KH_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110324">
        <property type="entry name" value="Ribosomal L27 protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0271">Exosome</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Exosome complex component N-terminal" evidence="5">
        <location>
            <begin position="30"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="6">
        <location>
            <begin position="144"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF14382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF15985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAG5095535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="238" mass="26610" checksum="3F50E4A290F31AEA" modified="2022-05-25" version="1" fragment="single">MADYPEINIRLAVNRIDTNLISRDNIQPRIYTPGEGVLTQTDYLRGHGTYVDEDECLRASVAGILEKVNKLITIRPLKARYQGEIGDVIVGRITEVQQSPEDEQTMRRYLQEGDLICAEVQSTYQDGSLSLHTRVLKYGKLSQGVMVKVPPALIKRKKTHFHHLANGATLILGNNGYVWIGASSQSADKSEGGFTQDLTRVAHEDREICARLRNCVLILSTCNILLTDTSVTYAYEES</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MPU8</accession>
    <name>A0A8J2MPU8_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS9728</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5100655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MPU8"/>
    <dbReference type="OrthoDB" id="7685400at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5100655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="102" mass="11546" checksum="999592EF992E4CA5" modified="2022-05-25" version="1">MDYSKVNVIGRCEDFLPSKKLSELEVNNIYTISDVKSVKANYGNTIIVSIDNEFSVFLPSRVAKILLDDPKLLEDMIKNAKENHLGLNYLGGKYNQFEFVGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MQG6</accession>
    <name>A0A8J2MQG6_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS10572</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5101670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MQG6"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5101670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="250" mass="27504" checksum="7B95B455E11D9A72" modified="2022-05-25" version="1">MDQKITWSLIIAGVVVIAGVAIWGIWFLLKGRRDPETKNKLRKELNEAIETASADAVTKFIDEISDRFIKNKTNLDAVKNEVTITLVANDITSRKTELVKKYTKADDTSAINGVDSSGNTGLTTAQKKVNAAIEEKAKEIVEDLISEKIKEKASCLSEKSAKSATDDDVWKLVEGLSDKKNAKANIIEKARNAANAKLKEIVTDPKWTVVETAVKTEGNTALKDKLSEITKKKDDFIDDAILEVAKVTKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MQH6</accession>
    <name>A0A8J2MQH6_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Similar to ANKDD1A: Ankyrin repeat and death domain-containing protein 1A (Homo sapiens)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HICCMSTLAB_LOCUS10602</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5101700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MQH6"/>
    <dbReference type="OrthoDB" id="448455at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01670">
        <property type="entry name" value="Death"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.533.10">
        <property type="entry name" value="Death Domain, Fas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011029">
        <property type="entry name" value="DEATH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000488">
        <property type="entry name" value="Death_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00531">
        <property type="entry name" value="Death"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47986">
        <property type="entry name" value="DEATH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50017">
        <property type="entry name" value="DEATH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="70"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="103"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="171"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="205"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="238"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="305"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="338"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="domain" description="Death" evidence="5">
        <location>
            <begin position="451"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="527"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="537"/>
            <end position="546"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAG5101700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="546" mass="60563" checksum="45ADAC946E8BD54D" modified="2022-05-25" version="1">MGDLTRSSATKMKIPPPLNLSSDPDDDSYNQKSRILKNDLLLHEAVIKNEPETVKKVLEETVDVNSRNNYGRAPIHWAASRGNTEIIELLMKADCDIEAKDKFGMRPLHMAAWYGHLDAVKLLVDAGANVEAVNKKKYTLLMCGSRGSSSIVIEYLIKVMEFVNVEATDNTGATALHHAAISGHPDVIKALSRIPGIKFNVTDKKGQTPLHCACAEGHMEAVETLINLGSNLNDRDNDGYSPLHVATRMRNTGIVQILLNANANCNITDDNGLTSLHMAASQGCKGILESIIDYCPDVINKQCNIGNTPLHLACQNNQMDTIEILLKKKADINCLNLKLQTPIHIAAEMGHTDVCKLLLAAGANIEQREKGGRTPLYIAARGSFTAIVDMIIKTARLGCPDSTVNDEDGLVRKKFNEPRWSTISANCAAVISDHIRSILWKLAYKHLENGDWKKLALHWSFTHEQIQAIEHQYDGPSSYKEHGHRMLMIWTSSLSPDTQVHEQLYQALCAIDKKNTADSIRKKYEEKYQDEKKKSGSKSCHQCLVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MQR9</accession>
    <name>A0A8J2MQR9_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">EB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS10904</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5102216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MQR9"/>
    <dbReference type="OrthoDB" id="504708at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006149">
        <property type="entry name" value="EB_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39069">
        <property type="entry name" value="ECDYSONE-INDUCIBLE GENE E1, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39069:SF8">
        <property type="entry name" value="FI17111P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01683">
        <property type="entry name" value="EB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035288435" description="EB domain-containing protein" evidence="1">
        <location>
            <begin position="25"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="domain" description="EB" evidence="2">
        <location>
            <begin position="107"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="EB" evidence="2">
        <location>
            <begin position="366"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5102216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="490" mass="55739" checksum="6DF8991DAC966F81" modified="2022-05-25" version="1">MSEKKTMLLKFLFITIIGVSLVHAYIRKTRESSSDYECRYYLELCDPDHFTPCCEENHECTKIESLSEHYCINQAGLDMKCYEDYDCYDNYSVCSKDSQKCTCDKNYITRDGSCQSIIGGNCDTDSDCLPFNSVCLNDFCECEHNFKPISDRECITIFLELPCQEDKDCYDINRAMCSENNTCTCRKNSISKNAYFNQTCEKKSDCYDTDRAMCSKDKRCICRPNHQTVNNATCISLIGGFCWRHSDCLPENTICIFDKCLCDLNFRADESNLQCVPKLRTFCELDEDCYKIRHAKCSKDKECVCRDDTIPLDDIKCAPLLGGFCWKNEKCAVNNSICANNTCRCQVGFSFQSKFECSEGVYDGKTLLGETCQISSECRPQNSFCVDKKCQCKSGLVPKFNDQCIPATLGSPCEIDKDCAEVTHAMCSKNEKRCICRPNNSELNSSRCAPILGGFCWKNEPCAITNSVCVDNECQCKKYYKALSQHQCII</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MQT2</accession>
    <name>A0A8J2MQT2_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similar to v1g140887: Protein UXT homolog (Nematostella vectensis)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS10588</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5101686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MQT2"/>
    <dbReference type="OrthoDB" id="433124at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23158">
        <property type="entry name" value="Prefoldin_UXT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009053">
        <property type="entry name" value="Prefoldin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004127">
        <property type="entry name" value="Prefoldin_subunit_alpha"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00293">
        <property type="entry name" value="prefoldin subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13345">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13345:SF9">
        <property type="entry name" value="PROTEIN UXT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02996">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46579">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="19"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5101686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="198" mass="22441" checksum="C6FF809E439EFB2E" modified="2022-05-25" version="1">MAMNEELSKKIVKFEKFINEVLKSDLKKFEEKLDVKNTELAEFIQLKSVITTLKSTECNESGFKTQVDLGNNFFIQATVEDASKIFLDVGLGYFVEFNLDEAVVLINVRVKLLEMQISNLRKEIAKTNAHIKLLLMGMRNLQASASESLAAPLSPQPVVRKLHYASPEENHLPVTEDQPRFWSKTWKAICARALSPPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MRT0</accession>
    <name>A0A8J2MRT0_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Arginine/serine-rich 7 (Caenorhabditis elegans)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HICCMSTLAB_LOCUS11994</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5104422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MRT0"/>
    <dbReference type="OrthoDB" id="7763451at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12259">
        <property type="entry name" value="RRM_SRSF11_SREK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000084">
        <property type="entry name" value="Serine/arginine-rich splicing factor 11 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32343:SF22">
        <property type="entry name" value="LD29830P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32343">
        <property type="entry name" value="SERINE/ARGININE-RICH SPLICING FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="165"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="278"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="287"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="417"/>
            <end position="527"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAG5104422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="527" mass="61502" checksum="790E927A70682ABA" modified="2022-05-25" version="1">MAVGTTKVVQVTNIAPQATKDQMQTLFGYLGKIEDIRLYPTIRDVAVPVQSRICYIKFHDQGSVAVAQHMTNTVFIDRALIVIPYQNGDIPDEQRALELTNNGTVVPGLYPSEPKLPANVVNSIDGIPPHHTILTIDPKLDAHGLPPYPPLPGHLDSRRIEEIRRTLIVANLDASVSSDQLLEFFTNNNIEIKYLRLCTRDSDTEHYALIELNEQTQVVPTLMLNGKMLADKPIKLYHSMQAISKPEAKSNEAAQKEIEEAMSRVKEAHNLISAAIDPMIGMLSKDKRSRSGSRSRKSRSRSRGRRRSRSRKRSRSRHRRSRSRHRRRSRSRSKRRSRSKDRKRKSPSRRRSTSRSRVRSRSRSRRSRSKRSRSRSKDRKKKSSPRRRSRSRSRSKRSKSKTRRSRSKSKSKFSKSKYSEKPRDKDREKDKEKDRDKEKDRDRRSKDKSDGNGKKDSDREKERDRDKDRDRDRDRDRDRERDRDRDKDRERSEKKSRDKKADKESKERSDDKSSSRSGSKEKIESEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MT75</accession>
    <name>A0A8J2MT75_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS7108</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5093782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MT75"/>
    <dbReference type="OrthoDB" id="10003277at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057435">
        <property type="entry name" value="Lips"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37686">
        <property type="entry name" value="LD36006P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37686:SF1">
        <property type="entry name" value="LD36006P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25228">
        <property type="entry name" value="Lips"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="603"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="695"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="990"/>
            <end position="1022"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5093782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="1187" mass="135462" checksum="52E052C8CFA1E000" modified="2022-05-25" version="1">MPHNLNITSANSANSGPNHQAYPPPQPYHINDGLQPEKEPVEFDASHLRGAPAEVEALVHNIKEVAQQFLYHWRTFPIVLPPPLSACTDGEDTLVRKKHHLRDLFIAPSFDELDAVAVDSKGEPRRLTNKQLESIRERGLHKDKYGKPKKLNATQLESIRRCGEFEVDSINFTGQTHRWRLSGLLQRGRDRRRETLLKDLALATRFIVVTARARLVSHCFSISQALKALLTGFLRLLDIIIGVPSLQAQNLDGKIREERCRYLVAELVCRPEYDDSLELLCGFIRKQLRRATMEKFEVERESSQLLPVSVPFVFGTPAGTAVDLRLFSRDIIRKALSTLVSILERETRGWFLHFRERLISELRAQKKSDEEIEQAKSSICTIKQLQVNEAVMREYLQRVYSSILSHPDILALGDGIAQLLIEQAQSVVLMHRAVQNVQRKLQHTKESLRYKMESEHPVLARIGPWMRDRMREAEANFIEECEWSAHEEALSLCNRQNLRQTVYFLNRDLTFMKEREPVLLKELRKVKTPTRSFQWPTQIWLPRNWIVRRNFQGVSEIIPTVLSNTPTSITTPRADPSQPVFLVEREICHTTTTRWPMWRWINYIARTWCWTWNAMFLFGVAVPWCSRVSLRALLLVEPFTPDLEMPIVTLLLHAFMALVMDLDSPEPSRNRYLVVMEALVWNIGIQGCLQPIVALLVAVCICPIISFLILTIAVIRYWIRVMWDTAMFHLVIKNRGRVPASDSFVVKRIAGPGLASDYYYQIRPEQALAAFEAKLELDELLAFQQETERLITQPQRDFTQFVEACFSPFATSLAKTRDPYKSLEKEARDLVAVLHEKLDRRRKDLQTGLGVAVRSKIKLTTFDLKIVIQQAALMLERLYPSHVLARLNGCEEDFWENKGLNVGDWAGLAGLMYADMFSLDFLQPLDDTDTKFKLEPHPGVDLTRYTEMVHSTELGGVNGLDLLGAIYAPRGNIQVQSPYLEVSYFNPRAKQASNSRKPEKRCETSLLTSPRSRRKTNSGLSVSDGRWQPWKREIRPYSAEKLVIPLPIPHPAHIAVNIHNRDSEDPIDLDSELCQNILRAIEESPGEMATECVGRYRGGGGDSSFDSVASQSSVSLETGLDTAEVLQEGEIKSESETYHWTLSNWGGGMARRRNNSGSIKVDLASPEDVTLDTDTTRVMFSTYGTTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MVX6</accession>
    <name>A0A8J2MVX6_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Bud22 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS9305</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5099929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MVX6"/>
    <dbReference type="OrthoDB" id="3364872at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="152"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5099929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="201" mass="23738" checksum="547F4A432F36477A" modified="2022-05-25" version="1">MTLEKTDDGKDNNNDRDDIEDKRRKDANKVKRKRIVDPFFISDDNDPVYLDIPVENNEDKKGQAGDRGKMGRNERNDFGKERRNNRNDFGRERRNDKFNNNSGNKFNRDNKFGKDSKFGRDRNKFNNDKSKFGDNKFNKGKINESRYGNKSNDFKKERNSFKEDKNENIAELHPSWAARKKQQDALKQGFQGKKIVFNDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MW60</accession>
    <name>A0A8J2MW60_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">ATP synthase subunit g</fullName>
            <shortName evidence="10">ATPase subunit g</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HICCMSTLAB_LOCUS9548</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the ATPase g subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5100427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MW60"/>
    <dbReference type="OrthoDB" id="437at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015078">
        <property type="term" value="F:proton transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015986">
        <property type="term" value="P:proton motive force-driven ATP synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016702">
        <property type="entry name" value="ATP5MG_metazoa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006808">
        <property type="entry name" value="ATP_synth_F0_gsu_mt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12386">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04718">
        <property type="entry name" value="ATP-synt_G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017835">
        <property type="entry name" value="ATP-synth_g_mitoch_animal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="4 10" id="KW-0138">CF(0)</keyword>
    <keyword evidence="5 10" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="6 10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR017835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAG5100427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="99" mass="11035" checksum="1F3B56384483A091" modified="2022-05-25" version="1">MSKLVPALINGAKKVYVVAKPEAVRFMRYAKVELSPPTVGDLPAIRQGFGKLLHSAKTGGYKNLTVSEAWLNTLVFIEVWCWFFVGEVIGKRHLVGYKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MWC2</accession>
    <name>A0A8J2MWC2_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Similar to ZBED1: E3 SUMO-protein ligase ZBED1 (Homo sapiens)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HICCMSTLAB_LOCUS9699</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5100626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MWC2"/>
    <dbReference type="OrthoDB" id="7696101at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009791">
        <property type="term" value="P:post-embryonic development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008906">
        <property type="entry name" value="HATC_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003656">
        <property type="entry name" value="Znf_BED"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052035">
        <property type="entry name" value="ZnF_BED_domain_contain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481:SF10">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05699">
        <property type="entry name" value="Dimer_Tnp_hAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02892">
        <property type="entry name" value="zf-BED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00614">
        <property type="entry name" value="ZnF_BED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50808">
        <property type="entry name" value="ZF_BED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="12" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="BED-type" evidence="11">
        <location>
            <begin position="11"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="65"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="92"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAG5100626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="695" mass="78744" checksum="7889B03CC55820A7" modified="2022-05-25" version="1">MYIILIVICKMAPSPVWNYFKKIENGNNVKCNECNKNLAYKNSTSTLIKHLKTVHKIELPNSFSESKKRKISEQDSDSDTSSVSQPKKINLCGTSNELVPSTSSSSSGLDLNEKPIYQGPLNRCLNNVISFSEGGYRNNDVTNALMYMIAVDNLPLCTPEKPGFRMFVRKLQPLYKTPCEPTITKRMTAKYEELKIKVKAELQKADSICLTTDIWTHQHTMRSYLGLTVHYLKGYEMNSYELGAYYLRDRKTIAVLRVKLRDICNEWEIDDDKISAIVSDGGANIKGAIKEEFGESKHISCFGHVINNIGQKLIEVGTSEPASELSDDKIHHLFDDESDTEEFFCEDSQNSSVRNLIMKVKKIVKFFRCSEVASRELEILQEQAGCKSALKLIQEVRTRWNSCYEMVDRFINLAEHVNCALLKVHRDKSSRSKPPDILTGDELDALIEIRDILKPLWNVTHEVSADKEVTLSKCIPLITGLKRGTDKLCPVTLIGQQMKKNLVTEIKQKFSNIESVKLYSIATLLDPRYKKIAFQSILNSARAVTTVGEILKKEIKSSKTLAIACESNLTDHQPSSDGNDLWDFLDDAVQHNIQVADSDEAGGLPIELRQFINRSTVDRKTNPDPIETWKSLESDYPYLSIVARKHLSIVATSTPCERLFSHSGLIANQLRSRLSPDHLNMLVFLKSIPQYLWFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MWT9</accession>
    <name>A0A8J2MWT9_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">DNA polymerase eta</fullName>
            <ecNumber evidence="5">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">HICCMSTLAB_LOCUS10062</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the DNA polymerase type-Y family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="5"/>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5100989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MWT9"/>
    <dbReference type="OrthoDB" id="5723at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005657">
        <property type="term" value="C:replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042276">
        <property type="term" value="P:error-prone translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009411">
        <property type="term" value="P:response to UV"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1170.60:FF:000003">
        <property type="entry name" value="DNA polymerase eta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.20:FF:000014">
        <property type="entry name" value="Polymerase (DNA directed), eta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1170.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.100">
        <property type="entry name" value="DNA polymerase, Y-family, little finger domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036775">
        <property type="entry name" value="DNA_pol_Y-fam_lit_finger_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017961">
        <property type="entry name" value="DNA_pol_Y-fam_little_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052230">
        <property type="entry name" value="DNA_polymerase_eta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041298">
        <property type="entry name" value="UBZ3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001126">
        <property type="entry name" value="UmuC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45873">
        <property type="entry name" value="DNA POLYMERASE ETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45873:SF1">
        <property type="entry name" value="DNA POLYMERASE ETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00817">
        <property type="entry name" value="IMS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11799">
        <property type="entry name" value="IMS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21704">
        <property type="entry name" value="POLH-Rev1_HhH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18439">
        <property type="entry name" value="zf_UBZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036603">
        <property type="entry name" value="DPol_eta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100879">
        <property type="entry name" value="Lesion bypass DNA polymerase (Y-family), little finger domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50173">
        <property type="entry name" value="UMUC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51907">
        <property type="entry name" value="ZF_UBZ3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0227">DNA damage</keyword>
    <keyword evidence="13" id="KW-0234">DNA repair</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="11" id="KW-0862">Zinc</keyword>
    <keyword evidence="10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="UmuC" evidence="18">
        <location>
            <begin position="43"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="UBZ3-type" evidence="19">
        <location>
            <begin position="768"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="492"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="604"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="718"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="813"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="493"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="746"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="813"/>
            <end position="825"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00044975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="CAG5100989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="850" mass="95544" checksum="D1246295109FF2F4" modified="2022-05-25" version="1">MTPYLHSIYNYKQVWIISKVEIINFAHNKTNKIKMSNLGDRIVVLIDMDCFFCQVEVKLAPELKGKPLAVIQYSSFGPGSIIAVNYEARDFGVTRHMKSDEAKEKCPQIELVTVPPLRNKPDTGRYRAAGKEVIDVLKKHCNVIERASVDEAYLDITDLVDKKMESVFGQPKDLVTQLKNTYVVGYCDYDTNDEEKRTEGVNRWITETFAELGDMQSRRLAIAGIIVEHLRAEIYSQCEYRCSAGISYNKILAKLACGLHKPNRQTILPLAAVPTLYSSLPVKKVRNLGGKFGNIVMESLGCNVMADLLRYSLQDLQRRFDEKTGSWLYNIARGIDNEPVTNRLVCKSIGASKNFPGKQAITKLEVLETWARELSLELSDRLEQDLEENQRRATSVTISYHYYQDRKIIAQSKVCSLPSYKAEKIASICVDVISKALQKPIALISMSAAKFVPIKGSESFKNFFKAPSKPTVATKTEIVAAKTEPVVTAEPVESNSNCISKHGANNENDRENKIDDDVDDIPSDKLEKICEEKLKISQVKDSCKKTESKIFNTPPSTLKSKLGSPKSLNLNKTLNGENFKNSFFMNILKSSKSSFDSKPSASTFKMLEESNEGSSGNHKSINDNEDQSIPEERKVNTEDLPSDYESPDIFAESQPQDTSRISELVCVDQKNVGEIKKTNSNEDLIKLKEIFPDLDNIDRSVMQLLPIELQRAANKYLQKKRSVDISPKSKKNNTKNSTSKTKGQKSKPEKPKKDNLIYNFLTKNSAGNDSTMKLCPECNQMIKEDKFAEHSDFHMAKNLHLAINQPTSVTAVVSETPSDSDTGTPTAKRKMNLNSFKSNKKPRNIQSFFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MWV1</accession>
    <name>A0A8J2MWV1_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Mitochondrial (Mus musculus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS10811</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5102030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MWV1"/>
    <dbReference type="OrthoDB" id="10052321at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019374">
        <property type="entry name" value="Ribosomal_mS22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13071">
        <property type="entry name" value="MITOCHONDRIAL 28S RIBOSOMAL PROTEIN S22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13071:SF4">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN MS22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10245">
        <property type="entry name" value="MRP-S22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5102030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="342" mass="39936" checksum="FD100E4AC3A4DCA0" modified="2022-05-25" version="1">MISARNVHLIFRRLQINTIGRHCKFSSAHLQEEQRDPGPVFINDEVQKLLKTLTRPDLQKVYRKRKDGQPIKDPQYKFMTDEELQDLMKKVQARVDEKLQMPPVVKKRKPITEVISKDPEIQGHDTTKYVFTDITYGVSAVDRLIAVRDPDGTLRKANWEERFRMNQTYFPVKGRELVTPRMFQDEYLKDLLKREEYEFVLDRACLQFDPDDPDFHRVTSAVYEAVNNTSQFKVFRSTRHYGPLVFYLTWNKNINNLLLEYITNGFIEDAVLLIKLYNKINPTSKAVDITHDGDDLKFIQNFADLESPIRGKLIAAVQSYKELAEARKKVEKGVKAAHGIDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MXG1</accession>
    <name>A0A8J2MXG1_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="16">CYP6JU1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">HICCMSTLAB_LOCUS11495</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Microsome membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5103409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MXG1"/>
    <dbReference type="OrthoDB" id="2789670at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11056">
        <property type="entry name" value="CYP6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000042">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050476">
        <property type="entry name" value="Insect_CytP450_Detox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24292:SF54">
        <property type="entry name" value="CYP9F3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24292">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 13 14" id="KW-0349">Heme</keyword>
    <keyword evidence="10 13 14" id="KW-0408">Iron</keyword>
    <keyword evidence="12 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 13 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0492">Microsome</keyword>
    <keyword evidence="11 14" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="9 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="13">
        <location>
            <position position="440"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CAG5103409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="500" mass="58457" checksum="BFD6CE957408B295" modified="2022-05-25" version="1">MDLITIILSIMFSLLLLYYYITNYNYWKLRKINGPKPLPFIGTIKDVLLGRLSIGNYSKKIYDQYPDERVVGVYAGMKKVLLLRDLELIKDVMMKDFSSFVDRGIGYHDKHEPLSANVGFVDEDRWRLLRRKLTPMFSPIKLKKMINLLVECADRLNENLMAVMGEDVEVRAVMQRFAIDVIGICGFGLKTDALMDEDNIFYKMGRRIFSMNLKNLIRLRMKSYAPLIYKFIGSYLTDWEMQKFFIDITRQSIEHRRKYNINRNDFIDLLMALKEKSQEDDDIILTDTDLAAQLFIFFIAGFETSGSTISNCIFELALNHTVQNKLREEINDELMRSGGEITYDGINNLKYLDKVMCETLRKYPPVNFTLRRSTQSYKFADINLTIPKGTTIWIPIFGIHYDSKYYKNPQVFDPERFNDEELNNRPQMSYLPFGLGPRNCIGLRFAKMEVKIALVKLLQTFKFDMCNKTDVNYTINEKLFLLAPLNGIHVKVSKIEQNKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MY16</accession>
    <name>A0A8J2MY16_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Similar to Wdr92: WD repeat-containing protein 92 (Mus musculus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HICCMSTLAB_LOCUS12280</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5106478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MY16"/>
    <dbReference type="OrthoDB" id="10248252at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10971">
        <property type="entry name" value="MRNA EXPORT FACTOR AND BUB3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="110"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG5106478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="335" mass="37130" checksum="FEF0A2B99903034D" modified="2022-05-25" version="1">MNNLDKPQIICHIEKSVDYSLFDAKWIPCSAKFVVMGSTPRGSGVIQIYEVSSGQLKLIKSIDRSNPMKCGTFKASNASVPVYSANAHSEIINAIDGAGGQSVGHGAPEIVTGSRDGSVKVWDPRQKGRPVAVFEPKEGDSRRDCWSVAFGNSYNSEERVVAAGYDNGDVKMFDLKAMSLRWESNLKNGVCGLEFDRKDIPMNKLVATTLESKFYLFDLRTQHPKRGFAYLTEKAHKSTVWLVKHLPQNREIFMTCGGGGSLCLWKYNYPEKRKQMDVDGIAYGVVGSVDLLQNNIISSQPISSFDWCQDKAGLAVCTSFDQCLRVLVTTKLNLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MYH6</accession>
    <name>A0A8J2MYH6_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS12898</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5107747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MYH6"/>
    <dbReference type="OrthoDB" id="7663022at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035222893" evidence="2">
        <location>
            <begin position="21"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="450"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5107747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="510" mass="58751" checksum="A3111D961CF4A3B1" modified="2022-05-25" version="1">MEISYWHLFIFLTKLLGVLSNSTEIKITSRNVPDVEFTTRKIAINIMKLNPDIKLPTINTSLLKSHDCNYKISAEIGNSSSLLHHWRKHIHHSKRHRKPLENLRKHHITSLSSQKNNLSFVLPMNWKRNRSVSPPSMNDPQQVFANLIHRIISINDNLNFLSTHSPPDNISQTNNAKNIYYDANNTIINFVANHTTNNSGLITPKFYNESHTGCNMTESLDNQSCNKDHLLNFSINKTSELLKANSTTPSSLVDHLKILTKSPNKSTAFEFNQPLTGDSFMRIFQKKPLLPVSENNYATTKSNFIIIDDLGFFGDPSDETPIIKPREVFHPRPSFIDYIFGENIDNPAPRIENRMKYVDFWNLETDKNKTIDPGMIKIKFKLRSDDINDQHLPLWKSDNNIFSSKVSEPQYNSRINNKREEIKVQDRFIPFRSIKQPKSKVLNESDFQSAFLSTFYITIAICGIFFAIAVWWRRFSVIKKSNFTSISDAIHLSPTPSSPLAARRPRHSRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MYM4</accession>
    <name>A0A8J2MYM4_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS13035</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5108033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MYM4"/>
    <dbReference type="OrthoDB" id="7699186at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34239">
        <property type="entry name" value="APPLE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34239:SF2">
        <property type="entry name" value="TRANSPOSABLE ELEMENT P TRANSPOSASE_THAP9 CONSERVED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="268"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="268"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="299"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="319"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5108033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="344" mass="38365" checksum="942C23A9FA1DFF2E" modified="2022-05-25" version="1">MGKDKKRSRERDENDNYGIWVDSDKENETVNPQVENPALKEQKSVSDSDKLVDELAQMQAEDGTQVVADTESTKTTEFKKLDDEVELLLGDDPGAKKKEQVGLHKSLVLRWSSWLTDGLPKEVKDKVLEKYSRKGNISLEAPELNEEISATLNETGVKRDQLFTLEQNLAGSALSTLGQGITMIIRDEEEPLDRLELLEKLADAGKLMAQLHYQVSSARRAFISPILTKSIKNLLQATKPGSLLFGEKLTEKIKTAKFMEKIGKEIKASPLPSSSSNNKKVSNPAPRRTLNWRVPYARQGNSYQGPKQYQTKFPSSQHSSKSTYSNASKSTSKTQPPTDAGKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2N0Y3</accession>
    <name>A0A8J2N0Y3_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS14104</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001886">
        <property type="protein sequence ID" value="CAG5110847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2N0Y3"/>
    <dbReference type="OrthoDB" id="10608483at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="50"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5110847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="129" mass="13871" checksum="66424ECB85BC4A0B" modified="2022-05-25" version="1" fragment="single">IQSGDVTSVPAVLSSLNSESGIKAFMNSVVNSNNNKMNDESSSRDPMVESSSNSTCSEQSLNKEPVCTQLLTQLNTAYQHLAPDAQAIDIMYLFELLGTDDDKMAVCYSSAVKKMAASPHLLGGTLFSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-10-16" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>S6D2S8</accession>
    <name>S6D2S8_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cc_RNAseT2.3_25.6b</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">Hypothetical ribonuclease RNAseT2-like3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">RNAseT2-like3</name>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS6054</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Philos. Trans. R. Soc. Lond., B, Biol. Sci." volume="368" first="20130047" last="20130047">
            <title>Functional endogenous viral elements in the genome of the parasitoid wasp Cotesia congregata: insights into the evolutionary dynamics of bracoviruses.</title>
            <authorList>
                <person name="Bezier A."/>
                <person name="Louis F."/>
                <person name="Jancek S."/>
                <person name="Periquet G."/>
                <person name="Theze J."/>
                <person name="Gyapay G."/>
                <person name="Musset K."/>
                <person name="Lesobre J."/>
                <person name="Lenoble P."/>
                <person name="Dupuy C."/>
                <person name="Gundersen-Rindal D."/>
                <person name="Herniou E.A.Drezen.J.M."/>
            </authorList>
            <dbReference type="PubMed" id="23938757"/>
            <dbReference type="DOI" id="10.1098/rstb.2013.0047"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5092328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="HF586472">
        <property type="protein sequence ID" value="CCQ71083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S6D2S8"/>
    <dbReference type="OrthoDB" id="7506042at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035395925" evidence="2">
        <location>
            <begin position="23"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="247"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="43"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="128"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="163"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="199"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="249"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5092328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCQ71083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="348" mass="37004" checksum="6C8E8401C9114EDB" modified="2013-10-16" version="1">MKCNKRLLVYLIFQALLMISEAGRNSKPKNPMSPFPGSGPGTRGTSSGRTNSGRASSTQTNVRGNQVSGPSHPNRAPVQPASVGALRWFNSQPPATLPLNRPQASGPLDWSKFPFSETAPGSGLQLGPHNSGTGSQVRPYNSGSGPQVGPNHLGSGPPARPHNSVTAPWSRFQTPGTEYSLGPHTPGTALSVRPHDSGASASHEPQTPDHSSPGTSQMGYPHFLINDNYPGLKPKRTDFGAEIGRLDRSSSASSSSLGYHSGSRSSISSISSTKVEPVGLKTPGSTAIMESAAHPSKCVDKTETTPKTIAPAEHCFDYFKFAVAWNPGMAYKLWLTRYKIRTDRIHQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-10-16" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>S6D2Z3</accession>
    <name>S6D2Z3_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Cc_bv8.10_35.4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">bv8-10</name>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS6212</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Philos. Trans. R. Soc. Lond., B, Biol. Sci." volume="368" first="20130047" last="20130047">
            <title>Functional endogenous viral elements in the genome of the parasitoid wasp Cotesia congregata: insights into the evolutionary dynamics of bracoviruses.</title>
            <authorList>
                <person name="Bezier A."/>
                <person name="Louis F."/>
                <person name="Jancek S."/>
                <person name="Periquet G."/>
                <person name="Theze J."/>
                <person name="Gyapay G."/>
                <person name="Musset K."/>
                <person name="Lesobre J."/>
                <person name="Lenoble P."/>
                <person name="Dupuy C."/>
                <person name="Gundersen-Rindal D."/>
                <person name="Herniou E.A.Drezen.J.M."/>
            </authorList>
            <dbReference type="PubMed" id="23938757"/>
            <dbReference type="DOI" id="10.1098/rstb.2013.0047"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5092543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="HF586473">
        <property type="protein sequence ID" value="CCQ71263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S6D2Z3"/>
    <dbReference type="OrthoDB" id="7671380at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5092543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCQ71263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="119" mass="13494" checksum="4D22B4613FC7228F" modified="2013-10-16" version="1">MENNYATITHVELERDIHIPLEWPIRGIESTLLSLAQKMIMESNTEKCFLEVQNIPAKLVRHPTRTGFVNIFQKVSHKEIEDAFRCDVASPKDDRSVKIDIACGSQSISKLSVANAKRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-10-16" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>S6D2Z5</accession>
    <name>S6D2Z5_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cc_bv3.2_18.1b</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">bv3-2</name>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS6217</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Philos. Trans. R. Soc. Lond., B, Biol. Sci." volume="368" first="20130047" last="20130047">
            <title>Functional endogenous viral elements in the genome of the parasitoid wasp Cotesia congregata: insights into the evolutionary dynamics of bracoviruses.</title>
            <authorList>
                <person name="Bezier A."/>
                <person name="Louis F."/>
                <person name="Jancek S."/>
                <person name="Periquet G."/>
                <person name="Theze J."/>
                <person name="Gyapay G."/>
                <person name="Musset K."/>
                <person name="Lesobre J."/>
                <person name="Lenoble P."/>
                <person name="Dupuy C."/>
                <person name="Gundersen-Rindal D."/>
                <person name="Herniou E.A.Drezen.J.M."/>
            </authorList>
            <dbReference type="PubMed" id="23938757"/>
            <dbReference type="DOI" id="10.1098/rstb.2013.0047"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5092548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="HF586473">
        <property type="protein sequence ID" value="CCQ71268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S6D2Z5"/>
    <dbReference type="OrthoDB" id="10376407at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036287032" evidence="1">
        <location>
            <begin position="20"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5092548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCQ71268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="213" mass="24165" checksum="98502B847E1CEF8C" modified="2013-10-16" version="1">MYNTSLLVFFVVILGTTWAHKIEERVEIVIGSRHSQAENNPQPTQAPNGNNPSTVVEYILGSVTNQTRNRYALFGKVKEIDILVPYTYDPRNGAPQNIEGIINGPSSSANIMSQVRHQVIQQTINFLTKSCQDFKIELYELIKKGKNVRTIADINMQVMSIESSLQNEQYLLDDFNNIKPSTPPKVDYFDRDLLDIHKQIQELKNKSLLATAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2023-09-13" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>S6D4X0</accession>
    <name>S6D4X0_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Cc_single_4.4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">CcBV_4.4</name>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS1898</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Philos. Trans. R. Soc. Lond., B, Biol. Sci." volume="368" first="20130047" last="20130047">
            <title>Functional endogenous viral elements in the genome of the parasitoid wasp Cotesia congregata: insights into the evolutionary dynamics of bracoviruses.</title>
            <authorList>
                <person name="Bezier A."/>
                <person name="Louis F."/>
                <person name="Jancek S."/>
                <person name="Periquet G."/>
                <person name="Theze J."/>
                <person name="Gyapay G."/>
                <person name="Musset K."/>
                <person name="Lesobre J."/>
                <person name="Lenoble P."/>
                <person name="Dupuy C."/>
                <person name="Gundersen-Rindal D."/>
                <person name="Herniou E.A.Drezen.J.M."/>
            </authorList>
            <dbReference type="PubMed" id="23938757"/>
            <dbReference type="DOI" id="10.1098/rstb.2013.0047"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CAJNRD030001116">
        <property type="protein sequence ID" value="CAG5075860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="HF586478">
        <property type="protein sequence ID" value="CCQ71360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S6D4X0"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5075860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCQ71360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="84" mass="9650" checksum="D4EFC521B540C6A5" modified="2016-04-13" version="1">MGLIVILINFNTENRKNNSDNPGRESNPVSFGCALRALPVKLSETTSITTFQSNNFLFNTIEKHLLEYSRYNYLSILKLMHRVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2E604</accession>
    <name>A0A8J2E604_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Similar to Supt7l: STAGA complex 65 subunit gamma (Mus musculus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HICCMSTLAB_LOCUS1080</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001116">
        <property type="protein sequence ID" value="CAG5074847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2E604"/>
    <dbReference type="OrthoDB" id="6021257at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06847">
        <property type="entry name" value="HFD_SUPT7L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006565">
        <property type="entry name" value="BTP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039460">
        <property type="entry name" value="SUPT7L/Spt7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28598">
        <property type="entry name" value="STAGA COMPLEX 65 SUBUNIT GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28598:SF1">
        <property type="entry name" value="STAGA COMPLEX 65 SUBUNIT GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07524">
        <property type="entry name" value="Bromo_TP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Bromodomain associated" evidence="5">
        <location>
            <begin position="133"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAG5074847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="318" mass="36332" checksum="ABFB3B147D39CF87" modified="2022-05-25" version="1">MKSSKNNGSSSTILWGELPTRENHKQEVITPDIIENIWRQVLDDCGSNNSEMDNYQTEPHPEFIQLPMENSLVLNTVALHRQKSSINNGLIVRGISTVEKQEEKPSNPFKFLPPREKREINKKFTCNLQPSTCRSLLKHAVTVLIAHIGYEQSVDTAIETLVDVAETLLRKITMMLKFACEQPNSGFPDPVERILVETGIGNVEEIHNYYQNYVVKFEEGMRKTVEAMVCKQQMELSSAAKMELDEVVNKLQFDDLENFVNAYKDVPTLQLLDPEIGFPPSLDAGFQMLHSLEQDELNNLEAEEEDSDVHHINKKYKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2E614</accession>
    <name>A0A8J2E614_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Serine protease persephone-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HICCMSTLAB_LOCUS1095</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="7">Belongs to the peptidase S1 family. CLIP subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001116">
        <property type="protein sequence ID" value="CAG5074862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2E614"/>
    <dbReference type="OrthoDB" id="6339452at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000028">
        <property type="entry name" value="Serine protease easter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1640.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022700">
        <property type="entry name" value="CLIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038565">
        <property type="entry name" value="CLIP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051487">
        <property type="entry name" value="Ser/Thr_Proteases_Immune/Dev"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033116">
        <property type="entry name" value="TRYPSIN_SER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24256">
        <property type="entry name" value="TRYPTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00680">
        <property type="entry name" value="CLIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00135">
        <property type="entry name" value="TRYPSIN_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 8 11" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0720">Serine protease</keyword>
    <keyword evidence="2 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035175380" evidence="9">
        <location>
            <begin position="20"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="10">
        <location>
            <begin position="106"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAG5074862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="370" mass="40843" checksum="E2990CD94138E84F" modified="2022-05-25" version="1">MKFIIFIFFGLFTTGFTQLEEGSECLLENGSPGVCTKLPECPPKLDDARKGRRTALSSRCGFAGFVEVVCCPAPVQGKINIRPADIACHDYENEILSGIERLTWHILAGIEAASEEFPYMAALGYVDKTSSEVTDDNSERKIIKIKYACGGTIIAPRFVLTAAHCVSNHNEDVPVLVRVGSVDLESKDEQTIPIKEIIAHPKYRRSTMYYDIALLKLFEAINWSKTVKPICLQTKSINETDLQVVGTYLVVVGWGHTDIDADQSTKLLKTPSLILEPRENCSTAYQRFRQLPYGLDERMICAKDPNTTRRADACQGDSGGPLLLLSSSGDTVIGVTSFGQSCGGPYAAVYTSVHSFIDWIESIVWPERII</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2EBA0</accession>
    <name>A0A8J2EBA0_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Olfactory receptor 233</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HICCMSTLAB_LOCUS955</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001114">
        <property type="protein sequence ID" value="CAG5074194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2EBA0"/>
    <dbReference type="OrthoDB" id="6614360at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005549">
        <property type="term" value="F:odorant binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004984">
        <property type="term" value="F:olfactory receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004117">
        <property type="entry name" value="7tm6_olfct_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21137">
        <property type="entry name" value="ODORANT RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21137:SF35">
        <property type="entry name" value="ODORANT RECEPTOR 19A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02949">
        <property type="entry name" value="7tm_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0552">Olfaction</keyword>
    <keyword evidence="8 11" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="9" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="30"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="143"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="177"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAG5074194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="243" mass="28079" checksum="51471DC2DBF8D3FB" modified="2022-05-25" version="1" fragment="single">KTREFPVRGSFPFDVTQSPIFEIILGSQCYGLLIACMWILVFDTLLLGFIRWINVQLMILQANFRHCNDITTSRASLSVSQQNYNIIQAYQFLKVPEEQEEFRSFAPFTLEEANVPADSFLLRFRACVIHHRRLIDNLNDCNSLFTVVLFGQIFSSCILICVGLFVLVVSLHENRNIFKDIVMLGYGLVHLFYWCIYGDQLMIEVIIPNCNSQFIYECGWENNLSRKSKRLILNGLTQGLTPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2EJB8</accession>
    <name>A0A8J2EJB8_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Similar to CG5641: Interleukin enhancer-binding factor 2 homolog (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HICCMSTLAB_LOCUS1212</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001116">
        <property type="protein sequence ID" value="CAG5075014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2EJB8"/>
    <dbReference type="OrthoDB" id="5775647at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.460.10:FF:000093">
        <property type="entry name" value="Interleukin enhancer-binding factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1410.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006561">
        <property type="entry name" value="DZF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049402">
        <property type="entry name" value="DZF_dom_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049401">
        <property type="entry name" value="DZF_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052134">
        <property type="entry name" value="ILF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46447">
        <property type="entry name" value="INTERLEUKIN ENHANCER-BINDING FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46447:SF1">
        <property type="entry name" value="INTERLEUKIN ENHANCER-BINDING FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20965">
        <property type="entry name" value="DZF_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07528">
        <property type="entry name" value="DZF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00572">
        <property type="entry name" value="DZF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50152">
        <property type="entry name" value="25A_SYNTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51703">
        <property type="entry name" value="DZF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0010">Activator</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="DZF" evidence="8">
        <location>
            <begin position="24"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="352"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="364"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAG5075014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="381" mass="42473" checksum="C6BAEBA58467E11E" modified="2022-05-25" version="1">MVRGRGGMIRGRGGIGRGMGFIRKQFLLRHLFDYTLCEAAFPPVKPMPDESDFTMALLKKNSDMCPTPKEQTAILDLTVKLQSVLDNLIVAPGTFEACQLEEVRKVGSFKKGTMIKGHNIADIVVILKTLPTKTAVEALGNKVYLDLKTVNPKDVFKLTQTERGFDIANNEATVRVLITTLHQNLRKLESDQHIDVKICQGHLAAIRHSRWFEENAHHSSIKILIRLLRDLRSRFEGFEPLSPWMLDLLAHNAIMNNPGRQALPINQAYRRVLQLLSSGLFLPGSAGISDPCESGNIRVHTAMTLEQQDQVCLTAQTLLRVLAHGGYRPLLEGGNKLAVEMSVWPGGVVASPLDKAYEPPTDQEQQEDMDESNEEMMTDTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2EKJ4</accession>
    <name>A0A8J2EKJ4_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similar to CG42342: Collagen alpha chain CG42342 (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS1791</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001116">
        <property type="protein sequence ID" value="CAG5075650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2EKJ4"/>
    <dbReference type="OrthoDB" id="8964326at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005581">
        <property type="term" value="C:collagen trimer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0176">Collagen</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="108"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5075650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="150" mass="16104" checksum="E60D431193A4AD9A" modified="2022-05-25" version="1">MGNCKFIWEINFTECVCVSACVLSGREQQKPDFRVFLQQFHTSVAINHSCNVTVLQGSKGDTGAPGETVSRKGDKGIKGDQGVPGLDAPCPLGADGLPLAGCGWRAPQQDIVSTMSPAHEGPEPAETDYDEPEDEYEEEYTDPSGNLAEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2EKU4</accession>
    <name>A0A8J2EKU4_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Large ribosomal subunit protein eL6</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">60S ribosomal protein L6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HICCMSTLAB_LOCUS2196</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of the large ribosomal subunit. May bind IPO9 with low affinity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001117">
        <property type="protein sequence ID" value="CAG5076470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2EKU4"/>
    <dbReference type="OrthoDB" id="2436667at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13156">
        <property type="entry name" value="KOW_RPL6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.30:FF:000014">
        <property type="entry name" value="60S ribosomal protein L6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000915">
        <property type="entry name" value="60S_ribosomal_eL6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041997">
        <property type="entry name" value="Ribosomal_eL6_KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005568">
        <property type="entry name" value="Ribosomal_uL6_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10715">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10715:SF0">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01159">
        <property type="entry name" value="Ribosomal_L6e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03868">
        <property type="entry name" value="Ribosomal_L6e_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 10" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL6 N-terminal" evidence="9">
        <location>
            <begin position="19"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="7"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00034092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00046388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAG5076470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="265" mass="30291" checksum="ECD4494DB42F23F1" modified="2022-05-25" version="1">MADTKAKTPAKPAASATPVKKAGKPRNYDLGNGVYRFSRTRMFHKKALWKFLDKKTPKTVKPKKPLTIEKKINGEKNGGTRIVRLQKRRANYPTVDPVTVHHAKKTYREHSRYTRPSLVPGSVLILLAGRHKGKRVVLLKVLKSGLLLVTGPFLINACPMRRVSQNYVIATSTRLDMKNVQVPEKLDDAYFKRKREKRAKKEEGDIFTKKAEEYKASDERKADQKVVDKMVIGAIKAHPDKKMLFTYLSAMFGLRSSQYPHRMNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2EMP3</accession>
    <name>A0A8J2EMP3_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Similar to Kr: Protein krueppel (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HICCMSTLAB_LOCUS939</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001114">
        <property type="protein sequence ID" value="CAG5074167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2EMP3"/>
    <dbReference type="OrthoDB" id="654211at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002343">
        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000912">
        <property type="entry name" value="Zinc finger protein 660"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050331">
        <property type="entry name" value="Zinc_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515">
        <property type="entry name" value="PR DOMAIN ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515:SF58">
        <property type="entry name" value="ZINC FINGER PROTEIN 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12874">
        <property type="entry name" value="zf-met"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="195"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="223"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="251"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="279"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="131"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="391"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="405"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="434"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG5074167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="470" mass="53399" checksum="64B980DD6CC82A4B" modified="2022-05-25" version="1">MENFTGPRYRQTNDLVQEPNFRQYCLDRVVNQKDFFFCLRTGQLDIKDEKHSPPLNNNTLALYPHLQASAPQSMSLFSPEQILATQTAALMNTRLPPGLQATLAAAANSALYNQNQMALFAGWIPSPSPPQAPISPILKQSLKRTTTSPTEPIKRPRKRGPKAKEEVPIQAPPSPPNSVSPEAPSKDTAPRDKVFTCGVCLRSFGYKHVLQNHERTHTGEKPFECPECHKRFTRDHHLKTHMRLHTGEKPYHCSHCDRQFVQVANLRRHLRVHTGERPYACELCSAKFSDSNQLKAHLLIHKGEKPFECEHCNVRFRRRHHLVHHKCGVAATAQDLISSAHAQLANQRFGLTRDREYVRERESVISDDFEDDLDEDLERKKIADLPINLSVPMELPEQTEPEDLSMSTGSMRGHSNSHSGGDSPLSRSPSSDIHDDDDDEDIDDLNGRLFLSKQNLDVFRHRINHSKSRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2025-04-02" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2EMY2</accession>
    <name>A0A8J2EMY2_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS1165</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001116">
        <property type="protein sequence ID" value="CAG5074954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10509224at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="313"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="637"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="740"/>
            <end position="1346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="349"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="370"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="637"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="677"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="710"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="742"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="807"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="837"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="883"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="895"/>
            <end position="911"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="937"/>
            <end position="947"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="972"/>
            <end position="984"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="985"/>
            <end position="994"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1018"/>
            <end position="1029"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1057"/>
            <end position="1066"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1167"/>
            <end position="1180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1182"/>
            <end position="1206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1213"/>
            <end position="1226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1281"/>
            <end position="1291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1298"/>
            <end position="1307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1318"/>
            <end position="1346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5074954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="1346" mass="151833" checksum="B6B395AD9025EE60" modified="2022-05-25" version="1">MVNLAGSNINQSLNTLENFVGKFVLWRRLFQKHLDYDNDSVSVYLVKNNPDLVITSLFQRFNGERKTNYDNVNKLSTVVENDCFNAYVIGRNVKSLTNLNPKLKHTPVHYNDMATVYNEYVKKLNDFVNESTNSIVYTSKSNVKHTVSIDKLIEQLNVLIQADECNAYGREILTRYKTDLTKFLPRGFYDNSSVLPITVLDDYDADDDSSTNISSLQTVSTYTRSSVSTYSSSSEASVEEKGVSQFPRECDKSVKIQNGNLDLDSVEDNMMYSYSFCNTDNFRRFQFVGINVRLAGGRETDDSREPLIIEELNEDDDGSLEDKVLDNEEGNLEGLKKEGINDDDMEGISDDKVDKIEGEEKGNEGNQEVCLDDDDDDDDDEIPRKRRKIEDIKKNFHNTMNSSKKVGNLATDVSVDESIEALITFMCDVLNDTEEYRKILENEYNDCKTELQKNTSSVSHDDYTRIEKLCDKFQTQLNRFSKAFTQDYLDILTVGLELYNLRVEHGSAMKEYDRFDVEDKKFVKKATNLARKIKRIIKKHDKLAVVYNTQIDKLDTFHKHLEKQLIIYTTNYDRKFVIPVKDYIAEFRSVKSDKTTKKKGQIISDHLNDMLKRMSGNGDGSPLIRISKLEDVNFDRNAADERKRKGEDSESDEAKKRNAAESDKPSSNKTRIPRETAGNQYNVQQNVQKSSRPSQIGSLLKSGSRRDNLPNLQRLSPNASQENMEHSDGLELGLASLASKLHPNDRSSSETLTKERYRENRSRNLEGIRENKREERKKISKDNLQNLVMSRRGVPQNLGEESDSDAVNDNQNENSSSLDNSQPDNKNIPPISRLESDVAASDSANSNSYSEGSLESGPPSLASEFESIGETGMINSPHIMDYPEIDDEEIDDSDEASKIDSPVEHLRKEELITDLDPTDESSPKSSTKNRYKGNRSKTLENIRENIREKRKKNSKDKSQDLVVKLRGVKEESGEDSDSDADNDNQNENSSSSENSEPDNKKIPSISRLESDVAASDSESSDSDSEDSSESDSASSASESEEIGETEVINSQQIMDYPETDEEEKDDSNDAPKIDSPVEPLSSKKLTTHMDPNDGSSQNRYKGNRYKGNRLKTLENIREKRKKNSKDKSQDLVVKLRGVKEESGEDSDSDAVNDNQNENSSSSENSEPDNKKIASEKRLESDVTASELQRLQSEDTGSSHSDSTNDSGKLAQKRHLEENEDPYHDVLEYSAPISKKMLVSKRKLKSDVTASDSEGSQSEDKGSSHSDSTNDSVRPLLKRHREKNDDPYHDVLEYSAPISKRKMVSIKKLKSDVTASDSENSDSDSDSDSDSDSDSDSDSDSDSDSDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2EP23</accession>
    <name>A0A8J2EP23_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS2149</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001117">
        <property type="protein sequence ID" value="CAG5076335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2EP23"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5076335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="74" mass="8277" checksum="110265ADEEB21556" modified="2022-05-25" version="1">MIFHVDPTDIVLFIKVRQYANKQKVGELNTKPQGLWELLWGHFFFAGFPSLSGKYLTTALCGEACDCPDAVVSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2EP69</accession>
    <name>A0A8J2EP69_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to UPB1: Beta-ureidopropionase (Pongo abelii)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS2269</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001117">
        <property type="protein sequence ID" value="CAG5076759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2EP69"/>
    <dbReference type="OrthoDB" id="412018at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003837">
        <property type="term" value="F:beta-ureidopropionase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033396">
        <property type="term" value="P:beta-alanine biosynthetic process via 3-ureidopropionate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050345">
        <property type="entry name" value="Aliph_Amidase/BUP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43674:SF2">
        <property type="entry name" value="BETA-UREIDOPROPIONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43674">
        <property type="entry name" value="NITRILASE C965.09-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CN hydrolase" evidence="2">
        <location>
            <begin position="66"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5076759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="236" mass="27277" checksum="C27AE26CE585335E" modified="2022-05-25" version="1" fragment="single">MESFNLEETLKKHLPKEEYSKVVKILYGTPIESLNLKNYQGKNDLEVQGYDFLPCTITESTPKRRVRVGLIQHQVTYPTDRPISEQLSDIHRKIDDYIKYAAANDVQVLCLQEAWNMPFAFCTREKYPWVEFAEDVNSGPTTKLLSTLARENKMVIVSPILERDTVHGDTLWNTAVVIDNYGQVLGKHRKNHIPRVGDFNESTYYMEGDTGHPVFQTDYGKIAINICYGRHHPLNW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2GZ89</accession>
    <name>A0A8J2GZ89_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Similar to fd59A: Fork head domain-containing protein FD3 (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HICCMSTLAB_LOCUS191</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001001">
        <property type="protein sequence ID" value="CAG5072792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2GZ89"/>
    <dbReference type="OrthoDB" id="5402974at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009653">
        <property type="term" value="P:anatomical structure morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20048">
        <property type="entry name" value="FH_FOXD4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000016">
        <property type="entry name" value="Forkhead box protein I1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001766">
        <property type="entry name" value="Fork_head_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050211">
        <property type="entry name" value="FOX_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018122">
        <property type="entry name" value="TF_fork_head_CS_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030456">
        <property type="entry name" value="TF_fork_head_CS_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11829:SF402">
        <property type="entry name" value="FORK HEAD DOMAIN-CONTAINING PROTEIN FD3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11829">
        <property type="entry name" value="FORKHEAD BOX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00250">
        <property type="entry name" value="Forkhead"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00053">
        <property type="entry name" value="FORKHEAD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00339">
        <property type="entry name" value="FH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00657">
        <property type="entry name" value="FORK_HEAD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00658">
        <property type="entry name" value="FORK_HEAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50039">
        <property type="entry name" value="FORK_HEAD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Fork-head" evidence="8">
        <location>
            <begin position="97"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Fork-head" evidence="6">
        <location>
            <begin position="97"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="346"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="354"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAG5072792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="365" mass="40482" checksum="693A98B0FF4FBBFE" modified="2022-05-25" version="1">MDSSVMSNTSCDGGIDSDRNSDSSSMIVDPVSLDQKDLSSRLSKGFDVSSHFVEIATTTVKSRNRNIKKTLTMISETQKTEQSPTYTAEKMTSTQIKPPYSYIALITMAILQSPQKKLTLSGICEFIMARFPYYHEKFPAWQNSIRHNLSLNDCFIKIPREPGNPGKGNYWTLDPLAEDMFDNGSFLRRRKRYKRPPPHYVLRDRAIMATFAICGDRNGYPVGDHSGGFAYPGVSSNAYLTPPHRLPILDFPPSTLEALKLSAFIETPPPLYKPVPIIAPHQHIRQLVNNTTSALPMTMTTMTSIPGRLAISVTSGAVDKKTSFSIEALIGKKTQSDQNINDLLDLSPSEQREIGSQASAFSPLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H079</accession>
    <name>A0A8J2H079_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to pol: RNA-directed DNA polymerase from mobile element jockey (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS103</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030000620">
        <property type="protein sequence ID" value="CAG5071954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H079"/>
    <dbReference type="OrthoDB" id="7989680at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33481:SF1">
        <property type="entry name" value="ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33481">
        <property type="entry name" value="REVERSE TRANSCRIPTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="26"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5071954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="262" mass="30345" checksum="01C2CD80B33E9AFE" modified="2022-05-25" version="1">MSLLALFGLNIDEDKFALAYADDMIVGLAGKQLLELQEKLEQLVNNINNVYKIWNLRINPDKCETIVFRRESNHLSKNALTQIKNFQISTPSPNTNEPINIPHKTIVKYLGVHIEQLLRLRHHPDIQLAKAKAAFKANNRIFYNKNICRKTKIICYLLLVRPILTYAAPIWWNTSAAVFENYRVFERKCLRACIGAYRSAESNFKKFIMVDSQLKTPQHRQAATTGTTQRTVDLTRIYTEKSLKIPPQLWHPNNLINPIKVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H0A2</accession>
    <name>A0A8J2H0A2_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Similar to Herc4: Probable E3 ubiquitin-protein ligase HERC4 (Mus musculus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HICCMSTLAB_LOCUS1779</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001116">
        <property type="protein sequence ID" value="CAG5075626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H0A2"/>
    <dbReference type="OrthoDB" id="5981550at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009966">
        <property type="term" value="P:regulation of signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00078">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2160.10:FF:000004">
        <property type="entry name" value="probable E3 ubiquitin-protein ligase HERC4 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2410.10:FF:000003">
        <property type="entry name" value="probable E3 ubiquitin-protein ligase HERC4 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2160.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2410.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000569">
        <property type="entry name" value="HECT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035983">
        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058923">
        <property type="entry name" value="RCC1-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051709">
        <property type="entry name" value="Ub-ligase/GTPase-reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45622:SF76">
        <property type="entry name" value="HECT AND RLD DOMAIN CONTAINING E3 UBIQUITIN LIGASE 4, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45622">
        <property type="entry name" value="UBIQUITIN-PROTEIN LIGASE E3A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00632">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25390">
        <property type="entry name" value="WD40_RLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00633">
        <property type="entry name" value="RCCNDNSATION"/>
    </dbReference>
    <dbReference type="SMART" id="SM00119">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56204">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50237">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00626">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5 6" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="836"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="7">
        <location>
            <begin position="41"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="7">
        <location>
            <begin position="96"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="7">
        <location>
            <begin position="146"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="7">
        <location>
            <begin position="199"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="7">
        <location>
            <begin position="252"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="7">
        <location>
            <begin position="304"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="7">
        <location>
            <begin position="357"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="domain" description="HECT" evidence="10">
        <location>
            <begin position="773"/>
            <end position="1099"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="6">
        <location>
            <position position="1067"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAG5075626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="1099" mass="123066" checksum="C597D8AAF0AEEC28" modified="2022-05-25" version="1">MDHQNNTASSSKKRRRNSSSDTNLSGTKKFIIDKTILILEADMFCWGSTVHGELGLGGIEEEIINVPREVTDFKQATEIKDIACGNNYTVVITQDGKIYSCGNNDSGQLGHDKPRKKLQLVSDLEAFVFKKAVCGASHTLAINEWGQLFSWGCNSDGQLGLSSFVPVQETPRMVKTLATSIVIQVSCGYKHAVALTNNGKLYSWGLNDEGQLGIGPESKIEHKPRLIKCLEAVPIAYVACGGYHTIVVSKSGSIYAWGRNTFGQLGVNCTQSSSLPCQLRTLRNSKVKHVACGEDFSAFLTMDGGVFTCGAGTYGQLGHGSATNEILPRQIMELMGSVVTQISCGTRHMLALIPSRGRVYAWGLGGAGQLGIKTTRTVTTPQVVLGPWVSPNGTSIYQSGAPTSEYSIDCVVKHIFTGGDHCFVTVTKRESNIPSDDSRIFDPSTQILTVTEEQLLFCQKVPMGAPLDHDLMMYLETVFRSQSSINGSFLLDNDQHYGCSSKHSGVDVVKASRLFGIISDFQNNTIQELIFTSIIDGLIPSLAASPPDVEALRVYLTLPLYHGFTEPTHCESLQRPFAKALNNLKPEAKKIVGIWWSKAPVQVFYRLIRSYKAIILLIMKQTKNIDNMHFSSDSTLKLSLELLKFINKLNQTENEGLRVPYDVFHLPELTTLIDIRTDYIKWLGNADSNSVGVALICNYSFIFDAEAKLLLLETDQAIQMHSAMNEAATRAFTNVMFNAFLPTDARQTSQFLMLNVSRENIVVDTLRELTSQNSSDLKKPLRVKFHGEEAEDAGGVKKEFFMLLLKEILDPKYGMFKQYDETRTIWFSEDSFEDEMMYFLIGVLCGLVIYNFIIINLPFPLALYKKLLNEPVNLADLKDLSPVLAKSLQSILDYNEPDLADVFSLNFEVIREVYGEQKVYELIPGGSKIAVTLENKQEFVNSYVDYIFNKSVESHFKAFYNGFHKVCGGRVLKLFHSHELMAVVVGHENYDWKELQDNAIYKEGYTKDDPTIVMFWQIFHELPLEEKKKFLLFLTGSDRIPLQGMKAIKITIQPMTDEKFLPVAHTCFNLLDLPRYQTKERLRYKLLQAIQQTQGFSLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H3L3</accession>
    <name>A0A8J2H3L3_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS1311</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001116">
        <property type="protein sequence ID" value="CAG5075157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H3L3"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5075157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="80" mass="9007" checksum="488E092C50DA832C" modified="2022-05-25" version="1">MSSNLKSVPPTVVAHDLSSLCDFKQIKKKKNEKLNLHLLARGAMGSTYFNYRLGFVITQNDTEANKKEMGSKSEIFWAIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H3W3</accession>
    <name>A0A8J2H3W3_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Similar to hfp: Poly(U)-binding-splicing factor half pint (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HICCMSTLAB_LOCUS1753</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RRM half pint family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001116">
        <property type="protein sequence ID" value="CAG5075599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H3W3"/>
    <dbReference type="OrthoDB" id="20943at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000380">
        <property type="term" value="P:alternative mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006376">
        <property type="term" value="P:mRNA splice site recognition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000381">
        <property type="term" value="P:regulation of alternative mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12370">
        <property type="entry name" value="RRM1_PUF60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12371">
        <property type="entry name" value="RRM2_PUF60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12648">
        <property type="entry name" value="RRM3_UHM_PUF60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000382">
        <property type="entry name" value="G-patch domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000136">
        <property type="entry name" value="poly(U)-binding-splicing factor PUF60 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000152">
        <property type="entry name" value="poly(U)-binding-splicing factor PUF60 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006532">
        <property type="entry name" value="PUF60-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051974">
        <property type="entry name" value="PUF60_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034209">
        <property type="entry name" value="PUF60_RRM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034211">
        <property type="entry name" value="PUF60_RRM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034212">
        <property type="entry name" value="PUF60_RRM3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003954">
        <property type="entry name" value="RRM_euk-type"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01645">
        <property type="entry name" value="half-pint"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47330:SF1">
        <property type="entry name" value="POLY(U)-BINDING-SPLICING FACTOR PUF60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47330">
        <property type="entry name" value="POLY(U)-BINDING-SPLICING FACTOR PUF60-B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00361">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 8" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="9">
        <location>
            <begin position="120"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="9">
        <location>
            <begin position="218"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="9">
        <location>
            <begin position="499"/>
            <end position="587"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAG5075599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="597" mass="65110" checksum="FF5592816FEC83C2" modified="2022-05-25" version="1">MNGTITMASSNQNISEPPMKKARIEGNASDFLPGPIYDLNQTGQVVGGPGAKYLSLPGILGAGLPKISSEQQDAINRAKKYAMEQSIKMVLMKQTLAHQQQQMASQRNQVQRQQALALMCRVYVGSISFELKEDTIRQAFLPFGPIKSINMSWDPVTQKHKGFAFVEYEIPEAAQLALEQMNGVMIGGRNIKVVGRPSNMPQAQSVIDEITEESKHYNRIYIASIHQDLTEDDIKSVFEAFGPITYCKLAQGSSPHRHKGYGFIEYETMQSALEAIASMNLFDLGGQYLRVGRAITPPNALMGPPSGTSMMPTAAAVAAAAATAKIQAMDAVASNAVALGLTKLGASGSPILNSGKALIFPLPGLVRPTLSPTAIITPPTIATVAPVIPPPGIAIPQTLTRPPAIIQPILGQPVIIPPPAIVTPTVVGAPVIPITTAPIVDVTRRAQEQAHLKQQEELQKKLLEETEPQTLQQQENMSIKGQSARHLVMQKLMRKIESRVVILRNMVAPEDVDETLQEEIQDECSKFGVVERVIIYNERQSEDEEDAEVIVKIFVEFSQMSEAERARDSLNGRYFGGRLVKGELYDQALFDHSDYSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H4X8</accession>
    <name>A0A8J2H4X8_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ceramide glucosyltransferase</fullName>
            <ecNumber evidence="5">2.4.1.80</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">HICCMSTLAB_LOCUS315</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>N-(9Z-octadecenoyl)-sphing-4-enine + UDP-alpha-D-xylose = beta-D-xylosyl-(1&lt;-&gt;1')-N-(9Z-octadecenoyl)-sphing-4-enine + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:70247"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57632"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:77996"/>
            <dbReference type="ChEBI" id="CHEBI:189081"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:70248"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>UDP-alpha-D-xylose + an N-acylsphing-4-enine = a beta-D-xylosyl-(1&lt;-&gt;1')-N-acylsphing-4-enine + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:70243"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:52639"/>
            <dbReference type="ChEBI" id="CHEBI:57632"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:189068"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:70244"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; sphingolipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Sphingolipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the glycosyltransferase 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.80" evidence="5"/>
    <dbReference type="EMBL" id="CAJNRD030001114">
        <property type="protein sequence ID" value="CAG5073371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H4X8"/>
    <dbReference type="OrthoDB" id="1483400at2759"/>
    <dbReference type="UniPathway" id="UPA00222"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008120">
        <property type="term" value="F:ceramide glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006679">
        <property type="term" value="P:glucosylceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02520">
        <property type="entry name" value="Glucosylceramide_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000041">
        <property type="entry name" value="UDP-glucose ceramide glucosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025993">
        <property type="entry name" value="Ceramide_glucosylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12726">
        <property type="entry name" value="CERAMIDE GLUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12726:SF0">
        <property type="entry name" value="CERAMIDE GLUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13506">
        <property type="entry name" value="Glyco_transf_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="6" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="13 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="6"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="284"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="318"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CAG5073371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="399" mass="45777" checksum="5D6805E90010E97D" modified="2022-05-25" version="1">MSSMIYTLYGFAIFFIVFWLGMWCVHILALITARCKLHRKTAVPASYEVPLQGVSIIKPLMGVDSNLYNNLETFFTLDYPLYEILFCVEDKQDPVLILIKKLMDKYPTVDARLFMGGCRVGVNPKINNMYPAYEAAKHELILISDSGIRMKEDTLLDMVRCMGDNVGLVHQLPFTYEQRQGFAAAYEKIYFGTVQSRMYLAADLLNINCHTGMSALIRKAPLDEVGGLKTFGVYLAEDFFYAKSLVDRGWKITVCSQPALQNSGQCELPLFQARLRRWAKLRVAMLPTTIILEPLSECFILGACASWAATVLFEWDSLVFYLIHILMWFMMDWTLLCVVQNSALPLNKLDFLFGWIMNETVRPYLFLQAVLDPLIQWRSRVYKLKWGGLAEEVKAKVKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H502</accession>
    <name>A0A8J2H502_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similar to Smox: Spermine oxidase (Mus musculus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS525</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001114">
        <property type="protein sequence ID" value="CAG5073616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H502"/>
    <dbReference type="OrthoDB" id="5046242at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046592">
        <property type="term" value="F:polyamine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.660.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050281">
        <property type="entry name" value="Flavin_monoamine_oxidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10742:SF398">
        <property type="entry name" value="AMINE OXIDASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10742">
        <property type="entry name" value="FLAVIN MONOAMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00419">
        <property type="entry name" value="ADXRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amine oxidase" evidence="1">
        <location>
            <begin position="12"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5073616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="469" mass="53302" checksum="5E45D3DC4CC33B86" modified="2022-05-25" version="1">MSRVIIVGAGPSGIAAASRLIQNGFDVTIFEAENRIGGRICSFQMGEYTADLGAEWVHGEKDNVAFELAWPLGLLERAYENKEFNSSGIFVGSDGEIISEQVAAPLLKLLENISDTVGDVVGTLKTGSVGEYAEIKINEYFKSHPEISADKHKPLMESLNSAQMTMDGAKNWHEVSAKGFKDYADCEGDQLINWKHRTYSTILDILMKKYPNPKEELPIRSKTKLNSKISRIDYSKSPIKVTTINGENFFADHIIVTPSIAVLQKNHETLFTPALTGKKLNAIMNLALGRIAKILVYYENPWWIGEPFWFRHLYWTSEDKKEIENDPQRRWMLGLTSSMRIEHRPKMMVFWVTGCYVHEMESIDEKLFQEQVKQVINKFFGKTHKLSEPKIIKRSLWNTNENFLGTQSFRPVKADLVDAHIEDYAAPIEVNNKPTILFAGEATSLHYSTVHGAIESGWREADRLINYYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H526</accession>
    <name>A0A8J2H526_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transformer-2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HICCMSTLAB_LOCUS828</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001114">
        <property type="protein sequence ID" value="CAG5074056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H526"/>
    <dbReference type="OrthoDB" id="439808at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12363">
        <property type="entry name" value="RRM_TRA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050441">
        <property type="entry name" value="RBM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48034">
        <property type="entry name" value="TRANSFORMER-2 SEX-DETERMINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="134"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="233"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="38"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="50"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="109"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="233"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAG5074056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="290" mass="34128" checksum="A2638C05DD82E49E" modified="2022-05-25" version="1">MSDIEHSGSRSASPRRPRTADGGIRDSRSRSRSRKSRERKERPVKEYSRSRSRSVSRGRKPYRNTKYAAGRSRSRSRSPYRGGDGRYSRSRSRSYSRSRYSRERDRNIYRSHSRSPMSSRRRHVGNRDNPCPSRCLGVFGLSIYTTELQIHHIFSKYGPVERVEVVIDAKTGRSRGFCFVYFKSSEDAKVAKEQCSGMEIDGRRIRVDFSITQRAHTPTPGIYMGKPTYLHDRGWNGPRRRESSNHRSSYRRSPSPYYNRRRPRYDRSRSRSYSPRKSDHSMFPKSPYRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H5H3</accession>
    <name>A0A8J2H5H3_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">PRKR-like endoplasmic reticulum kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">HICCMSTLAB_LOCUS1993</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. GCN2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="CAJNRD030001116">
        <property type="protein sequence ID" value="CAG5076012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H5H3"/>
    <dbReference type="OrthoDB" id="341578at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004694">
        <property type="term" value="F:eukaryotic translation initiation factor 2alpha kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034976">
        <property type="term" value="P:response to endoplasmic reticulum stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006986">
        <property type="term" value="P:response to unfolded protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000251">
        <property type="entry name" value="eukaryotic translation initiation factor 2-alpha kinase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050339">
        <property type="entry name" value="CC_SR_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018391">
        <property type="entry name" value="PQQ_b-propeller_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11042:SF91">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2-ALPHA KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11042">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2-ALPHA KINASE EIF2-ALPHA KINASE -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00564">
        <property type="entry name" value="PQQ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="20" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="7 20" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="20" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="18" id="KW-0732">Signal</keyword>
    <keyword evidence="11" id="KW-0346">Stress response</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="10" id="KW-0810">Translation regulation</keyword>
    <keyword evidence="13" id="KW-0834">Unfolded protein response</keyword>
    <feature type="signal peptide" evidence="18">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035217101" description="non-specific serine/threonine protein kinase" evidence="18">
        <location>
            <begin position="25"/>
            <end position="1018"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="19">
        <location>
            <begin position="540"/>
            <end position="978"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="345"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="428"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="686"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="734"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="350"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="17">
        <location>
            <begin position="694"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="569"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00037982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00041500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="CAG5076012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="1018" mass="115425" checksum="90F89A8A8AD63D6A" modified="2022-05-25" version="1">MWPTYIRQKISFILLFLITPNVIGDDNNHDIEPLRVCGSSTQDSPSTRLVFISTLDGKLTALDILNKGEKKWSMDFDNVPLVSSSIHKRELNEDGHWVKLIPSLNGGLYKFNGDTVEQIPISTDQLLLSSFRYSDNLVFSGGKEIQTYGIVSDTGKLLYHCTSSGCNNNTDGDRLHNDVLVIQRVQQTIRAVEPTTGTEKWNYSVGTHELNLIPTEKPCHKHPGHHTNHDNDNNIDIKVVIPQGLIWAVDKKNPSEILWRYQFDAPIVTVWQQTHDYSSNGHYYDTVKELNLFDNKQWSWGQDYPINPSIYIGMYERQVYVQESNVDKFFALTDLTNNRKSVQNTKNQINNNNNNNNNNNNVYPWRPHPAHENAVLRVENNPENVEISSINVDDSTAAGLSILYNSGYIDGNGYYLYAKEQSNNCNNTTSNNLLNDSDDAIPLKDSGSNSKAEDETSLETIIESLWIWWKEIVLLIIGTILLNILTQQLITSKFDNLRWGYSPPIIVEKYADPVIPPKETVPVSCENNNVEFDSPYSARFETINCLGKGGYGVVFEAKNKIDDCHYAIKRISLPDTPTSRARVMREVKALAKLDHQNIVRYFHAWFECPPLGWQKQHDSAIKQLMSNSVFSSEDSCLESRPVRTTTRDSNSVCIDVPISGLDLIEKELESKSQLLSDNDSFIVFDTDKSASTDQSDEVDDDDDDEDDDDDDDDDEALKVDGNWKAEKSVSDSIVFQMSDSKDKNEEVESDETDDENQKNVKVKKKPDCNKKSAKMFFYIQMQLCQRLSLQDWLRNTSNSGRDRKEVINIFQQIVDAVEYVHLQGLIHRDLKPSNILFAHDNKIKIGDFGLVTARTEDDVVCVDGNTDDDDSSSESNLRVKKHTANVGTHLYMSPEQVNGVIYDYKVDIYSLGIILFELLVPFSTGMERIMILGSLKKNIYPSDFAAKHPKEYDLLKMMLDKDPRKRPTAIGIKARPPLSNDQNITDTKYHFALPHVTRHSSSVSSSNSANSSELINSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H699</accession>
    <name>A0A8J2H699_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Similar to trp: Transient receptor potential protein (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">HICCMSTLAB_LOCUS2717</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001117">
        <property type="protein sequence ID" value="CAG5078364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H699"/>
    <dbReference type="OrthoDB" id="2373987at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034703">
        <property type="term" value="C:cation channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070679">
        <property type="term" value="F:inositol 1,4,5 trisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015279">
        <property type="term" value="F:store-operated calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051480">
        <property type="term" value="P:regulation of cytosolic calcium ion concentration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23650">
        <property type="entry name" value="TRP_CaM_bind1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.20:FF:000402">
        <property type="entry name" value="Transient receptor potential channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013555">
        <property type="entry name" value="TRP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002153">
        <property type="entry name" value="TRPC_channel"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00870">
        <property type="entry name" value="trp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10117">
        <property type="entry name" value="TRANSIENT RECEPTOR POTENTIAL CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10117:SF51">
        <property type="entry name" value="TRANSIENT RECEPTOR POTENTIAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08344">
        <property type="entry name" value="TRP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01097">
        <property type="entry name" value="TRNSRECEPTRP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01420">
        <property type="entry name" value="TRP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 10" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="9" id="KW-0407">Ion channel</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-0675">Receptor</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="546"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="636"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="10">
        <location>
            <begin position="146"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="domain" description="Transient receptor ion channel" evidence="13">
        <location>
            <begin position="181"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="945"/>
            <end position="1082"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="945"/>
            <end position="961"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1030"/>
            <end position="1073"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM01420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CAG5078364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="1155" mass="132718" checksum="C7F0E2E46344FBCE" modified="2022-05-25" version="1">MNQSESRENLVENEARAPSMQSLQPPTEYVLGQTEKHFLLSAERGDCATVRRLLEEHKDHPEILNINCVDPLNRSALIAAIENENVELIHILLEWKIQVKDALLHAIKEEYVEAVEILLDYEEKIHVPGEPYSWEALESGDYNFTPDITPLILAAHKNNYEILKILLDRGATLPCPHDARCGCDECVTSNDQDSLRHSRSRINAYRALTSSSLIALSSRDPILTAFELSWELRRLSRMEQEFRTDYNELKELCQVFATSLLDHVRTSHELEIILNYNPTGDNWEPGERQTLERLKLAIKYKQKQFVAHPNVQQLLAAIWYDGLPGFRRLSMVGQLIEVGKLGAMFPVYSTIYMVSPTSKMGLFMKKPFVKFICHSSSYAFFLMLLGMASQRVEYLAIELFGTAWMREILAGWKKHERGSIPGFVESGVIIYIISLVTAEIRSLWADGLLEYVSDLWNIVDFIQNTFYVVWIMMRATAWFVVQREYWSGEDPWYPRDQWDAFDPMLLSEGAFAAGMIFSFLKLVHIFSVNPHLGPLQISLGRMIIDIIKFFFIYTLVLFAFGCGMNQLMWYYADLEKAKCYHRNPDIPDFDNEEKACSIWRRFANLFETSQSLFWASFGMVDLMSFDLTGIKSFTRFWALLMFGSYSVINVIVLLNMLIAMMSNSYQIISERADTEWKFARSHLWMSYFEDGDTVPPPFNMVPTVKSFNKINPCGKTGRPTKSIMKKNREKAQERHDVVIRILVRRYVTAEQRKRDDFGITEDDVMEIRQDISTLRYELIDILRQNGMQTPNVDQNDASISGKKGRVMERRLQKDFQIGIVEGIVNSVIQSEKEPKDVFSQLARAIGKRASGSKKKDWNAVVRQSTIARDPIGSRTDAQIRQTRRSLRIHQRNHPESDLASLDPNRLVEYNPNLSEVSPATRVAYAKFIMGKMNKAELNRAVSFEKDDTANGGKDGKEENKTVSRSSSKVTISAPAQAKPNPPLSAAGSVSGSLRKTLLKATASMSSQDKGESSESRIIPSPIPEEPVDDEEKKKKEEEEKKKKEEEEKKKKEKEEEEKKKKEKEEQEKKKDEQPPAPAKTVPDKPKFYIHVFNTPLLAWSAAVTRILSMSFLPISRRLIDLKIHTRIEDRCTIHRIIFEEVENRAYNSKRFSVLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H6J9</accession>
    <name>A0A8J2H6J9_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similar to T: Transposable element P transposase (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS2846</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001117">
        <property type="protein sequence ID" value="CAG5078808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H6J9"/>
    <dbReference type="OrthoDB" id="7695767at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048366">
        <property type="entry name" value="TNP-like_GBD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21788">
        <property type="entry name" value="TNP-like_GBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transposable element P transposase-like GTP-binding insertion" evidence="1">
        <location>
            <begin position="53"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF21788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5078808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="210" mass="24592" checksum="E4D44402277D2F06" modified="2022-05-25" version="1">MENSEINVDAVVMDGASWNRGVWKIFGVNENNISCEHPYDSSRRLWMISDFHHLVKCFRTSTLDDKLHEFKTPFGTVKKRHWEALLEEENYRQPNLKIAYKLTPAHLKPKGFQAMNVPLATEVFGHEVSVAMAHYQSTCDELKDSTPTQNFIDLVFNLIQAMSSRIPRDALYVKEDCRQRQVRLVMKTKNNQKLKNSRFLWKNITRLSFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H7J4</accession>
    <name>A0A8J2H7J4_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Similar to akr1a1a: Aldo-keto reductase family 1 member A1-A (Danio rerio)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HICCMSTLAB_LOCUS3507</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aldo/keto reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5082264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H7J4"/>
    <dbReference type="OrthoDB" id="416253at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.100:FF:000006">
        <property type="entry name" value="Aldo-keto reductase family 1 member A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11732">
        <property type="entry name" value="ALDO/KETO REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00798">
        <property type="entry name" value="ALDOKETO_REDUCTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00062">
        <property type="entry name" value="ALDOKETO_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00063">
        <property type="entry name" value="ALDOKETO_REDUCTASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="7">
        <location>
            <begin position="20"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="4">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Tyr" evidence="6">
        <location>
            <position position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG5082264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="317" mass="35761" checksum="6FCDD8882321BD76" modified="2022-05-25" version="1">MALSVPKIKFNNGNEIPSFGLGTWKSKPGEVTEAVKYAIEIGYRHIDCALVYGNEKEVGAALKAKIGEGLVKREDLFITSKLWNSFHKPESVEKAIKKTLSDLGLDYLDLYLIHWPMAYEDGDVLFPTGPDGKPKLSDTDYVDTWKGMEGVCEKGLTKNIGLSNFNSEQIERVLKSCKIKPVTNQIECHPYLCQQQLTKFCKDRGIVITAYSPLGSPDRPWAKPGDPILLEDKKLIEISKKYNKTPAQVVIRYQLDRGHVVIPKSVTKARIMENAQVFDFKLTPEDIAYINTFDCNGRICPMSDCDKSPHWPFNIPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H7J8</accession>
    <name>A0A8J2H7J8_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Similar to SART1: U4/U6.U5 tri-snRNP-associated protein 1 (Homo sapiens)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HICCMSTLAB_LOCUS3378</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNU66/SART1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5081786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H7J8"/>
    <dbReference type="OrthoDB" id="5583at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000481">
        <property type="term" value="P:maturation of 5S rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045347">
        <property type="entry name" value="HIND"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005011">
        <property type="entry name" value="SNU66/SART1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14152">
        <property type="entry name" value="SQUAMOUS CELL CARCINOMA ANTIGEN RECOGNISED BY CYTOTOXIC T LYMPHOCYTES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14152:SF5">
        <property type="entry name" value="U4_U6.U5 TRI-SNRNP-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19252">
        <property type="entry name" value="HIND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03343">
        <property type="entry name" value="SART-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="629"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="190"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="36"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="74"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG5081786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="756" mass="86453" checksum="894EC1C2A4CA6884" modified="2022-05-25" version="1">MGSNKRHKSDKNKESKKKRHRSRSRSYSPDPDKSERHRHHKKHKRKERKDYDSDVEIVTTPPPPPKISKNHDVTPPPPEISRPRTPSPPARSSGSGGNSTLSMSIEESNRIRAKLGLKPLEVNAAPSKDDPAKIKDDLGEFYHKPAQNVAEKVQTEKVRERINVQKQKRMIETNLSKIRTLGDDDSDEDALAWIEKNRQLQEEKKKAELRAKQLDQLDEEFGIGDLVKEEVRNDRRAAYSDKDLRGLKVEHNIETFAEGQTVILTLQDKGVLDEGNDVLVNVNLRDDEVYHRNVKNKLKKPGYDAYDEDHFDEFGLPKNQVLEKYDEEIEGEKKQSFILGIDSAKEVQQRRSEIVKQRLANKRLESLKLQEPKLASEYYNEDELAKFKKRKKKVRKIRQSKTLKADDLVPDSTDYLRDLGSRRRKKPEETKVKADVSDALDVADYELPSRELLNAKIEEDKKEPVVSRVLSKKNQMKDSSSSFNETLLNLIKNEPSSEEKNISGNITLNATAEFCRTLGEIPTYGLAGNREDDDREMMDFEYDEPKEEPVELEDPDDGRGAWNTVKLDEVKREPVTLEAAILDAEPSLGQGLSGALRVAMSKGYLDQEDSNRPSASRFAHLQAQNYSIEDKTYGDDDKFGRRDRFNGPSSDFKEKEGFKPNVKLEYIDDEGHVLSSKEAFRYLSHKFHGKGPGKNKVEKRMKKAEQEVLMKRMSSTDTPLGTLNLLQAKQKETQSPFIVLSGNKHMQATSISKTKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H7T5</accession>
    <name>A0A8J2H7T5_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">E2 NEDD8-conjugating enzyme</fullName>
            <ecNumber evidence="7">2.3.2.34</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">NEDD8 carrier protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HICCMSTLAB_LOCUS3189</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>[E1 NEDD8-activating enzyme]-S-[NEDD8 protein]-yl-L-cysteine + [E2 NEDD8-conjugating enzyme]-L-cysteine = [E1 NEDD8-activating enzyme]-L-cysteine + [E2 NEDD8-conjugating enzyme]-S-[NEDD8-protein]-yl-L-cysteine.</text>
            <dbReference type="EC" id="2.3.2.34"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein neddylation.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.34" evidence="7"/>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5081084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H7T5"/>
    <dbReference type="OrthoDB" id="10249039at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061654">
        <property type="term" value="F:NEDD8 conjugating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd23794">
        <property type="entry name" value="UBCc_UBE2F_UBE2M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000239">
        <property type="entry name" value="NEDD8-conjugating enzyme Ubc12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24068">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="10">
        <location>
            <begin position="27"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00043698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00044047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00079113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAG5081084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="108" mass="12097" checksum="B3EFA6F2A039CD04" modified="2022-05-25" version="1">MIKLFSLKQAKKDGESPKPGSQKKASAAQLRITKDINELNLPKTCGTEFPDPDDLLTFKLIICPDEGFYRGGKFTFSFKVGPNYPHEPPKVKCETQVYHPNIDLEGNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H840</accession>
    <name>A0A8J2H840_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Similar to PLG: Plasminogen (Pongo abelii)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HICCMSTLAB_LOCUS3810</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5083339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H840"/>
    <dbReference type="OrthoDB" id="1915767at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00108">
        <property type="entry name" value="KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.20.10">
        <property type="entry name" value="Plasminogen Kringle 4"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000001">
        <property type="entry name" value="Kringle"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013806">
        <property type="entry name" value="Kringle-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018056">
        <property type="entry name" value="Kringle_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038178">
        <property type="entry name" value="Kringle_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050759">
        <property type="entry name" value="Serine_protease_kringle"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24261:SF7">
        <property type="entry name" value="KRINGLE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24261">
        <property type="entry name" value="PLASMINOGEN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00051">
        <property type="entry name" value="Kringle"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00018">
        <property type="entry name" value="KRINGLE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00130">
        <property type="entry name" value="KR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57440">
        <property type="entry name" value="Kringle-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00021">
        <property type="entry name" value="KRINGLE_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50070">
        <property type="entry name" value="KRINGLE_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1 3" id="KW-0420">Kringle</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kringle" evidence="4">
        <location>
            <begin position="16"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="Kringle" evidence="4">
        <location>
            <begin position="99"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="domain" description="Kringle" evidence="4">
        <location>
            <begin position="514"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="domain" description="Kringle" evidence="4">
        <location>
            <begin position="608"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="997"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAG5083339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="997" mass="114970" checksum="BFDA0019A1FC06D7" modified="2022-05-25" version="1" fragment="single">QQAGSDFTRCKFSQLGGDYVGTIAVTKSGIRCQMWTGIEQIHKVDERIRDIDFPDGSKSLAKNYCRNPTNDSRGLWCYTIEKSVEIEECDIPLCNYQENRVTGTGVEYGGKFKTSLSQKECKFWKTRHTIEEGDIATQTKRFPNTNFPEQSRERAKNYCRNPDGDNGGPWCYVDGVYENIVNKEYCDVPLADDRDCLVYTRSIDSYSTITKLDYSNQNITVWIKLWNPTFNYKTMATLLLSHVPVPATGKVIAELWKAGAEIAFSNTLTGLIYPGLNLHTNFKHTPHLITGENWTAITISWSLGYVTISLANSTEIIYAGEYAVKDSLSTLYPDGFLYYGLAGEGILWSTDLCLETCEIHTTFGYRYLRTWPIHSSYKSYSINFFLRSSFAISIQLYQTPGVQFPYFEIKMTQKGLITIIYQETSELPIHEIKNVESSEVLDYWTWEDFTISIFGSDLYILVHKYYGGVELLHVKYDLFKTVRWFSIGSERIAHWTLYCTPENKDLSEETSPPNCIASKEEKYEGAQWFTKNFFPCALWSSDMVPNDQKEDHLFPDGSVFNATNKCRKINFDAKTPYCYALWDSTATTAYKSDCLIPACRSASCRVVGTANDYIGTLSETRSGRRCALWLNQPGKKGEKKYLNDTLYPEQSVKDASNYCRNPSQSAAGTWCYTTDPLVTRDLCQVKDCDLPGEYIFLIKGDNIGRRMYILPKYRVKGIKINVKIWIPDDPDLIKIVFDADDGLNSSYKLIIGAENNSKILLYYKSEEKDYELVKEQISVHILFIARWSQFIIKIPRGKVQIYRDATSLLFEWEHEDPLKSFLPIYYYFSTEKNLMALSYDCVSTCHVEITTTNKIEKFFPIFSEDDTNYMHPQKLEFMIISNGDVQIPLILFPEDFEYYVLKIGQSTSTITLFNSYMTFLFQIVEKKSPVEQLLSEKEWSNITISWVNRTMQVFWNTIKLLDYEHTHPFVFYFFSVKLRTGFAKWTVNCLPPGKSII</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H8E6</accession>
    <name>A0A8J2H8E6_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Similar to IPO4: Importin-4 (Homo sapiens)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HICCMSTLAB_LOCUS4155</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5084614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H8E6"/>
    <dbReference type="OrthoDB" id="7862313at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001494">
        <property type="entry name" value="Importin-beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040122">
        <property type="entry name" value="Importin_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057672">
        <property type="entry name" value="TPR_IPO4/5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10527">
        <property type="entry name" value="IMPORTIN BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03810">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25780">
        <property type="entry name" value="TPR_IPO5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00913">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50166">
        <property type="entry name" value="IMPORTIN_B_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Importin N-terminal" evidence="9">
        <location>
            <begin position="19"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="641"/>
            <end position="667"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAG5084614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="1079" mass="121503" checksum="C67C0C76DB6A7EB3" modified="2022-05-25" version="1">MEEILAKLLLADNEAIHQGTAQLREALKNPESTLVLCQIIISSANPAIRHYGALLLRKRYTKTKYWSKLPINIKNEVKSILLQGLVNEADKSTKTGIAQLIGTIVKHELPNNGWPELFQFIQQLVSSANIIEKELGVFTLAQMTEIAPETYTAHLDSLAGLLVQTYSTLQDLGHPIAYYIIKIMMYLASLVEGNQAMVNAYNQMIPLAMGTIQSLSTKEPDKAQEAMELFDDLCEQAVTLISPHAKIFIHMCLTIGENKSLDDMLRVRALGSLAIIIRAKPRSIIKHKLMEPIVDTVFRVMCSPEDEEDDEDSNDDNPTYTPVTRARETLVVMAIHLKSEKLVPLLLRHVEPGVQSDDVWVKKAAFLTAASLAKGCSEYIRSKYLEYFLKCIYQGIKHSSHIVMSAALYALGKFSEYLQPEISQYSQELLPVLFDYLSQMCVHIKQEKSQPPAVDCMFYALETFCENLNDGILPYLPILMERLFETLSINAPNHIKELALSAIGAAASAAQEHMVPYFPKIITILDPYFTMVPDDNTMSLQVQSIDTLAILIRTIGEENFAPLVGKSLDLGMKLITENNDPDIRKAVYGLFGSLATITKKNLAPALPQILEFIFNSIQSSEGVVAHLKEFEDAAYPIYEDLSDSENDDEEDIEHTDNEDDGNDDDDDDIAAYTLGDSYIEEKEEAILALRDIAHYTEEAFLPYLEKAFEEVFKLVNYPQDDIKKVSIDALAQFCLNFSKIYSNEGKQALLKALSVFIPKLSELIRLDVEAAVVISGLEALAELLKEIKIDVLVGEGHKEAIMNCVTDVFTGKIECQDQEDAEEDDEAEQDEFLVECAGDVLSNFGKIISAEEFAHYFQTVLPFLKERTKHDKSDPQRSFAVGTISECLAALRHMTASFVPQLWPFFKKRIQDPSPEVRNNAYYGIGELVLWGKEAVQCHYNEIILIVANALQTEEHPGPRDNMVGIIARLIITNYSLINIEVVFPGFVQQLPLKKDYEEYLSVFKSILTLYRDKHEVLKPHIHTLLIIAINVLYEKKAPNEETKQVILEFIKSVQQDFSNEWNAVFSELPPDMKQILSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H9H7</accession>
    <name>A0A8J2H9H7_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to RCJMB04_19n18: Uncharacterized protein KIAA1143 homolog (Gallus gallus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS3510</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5082273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H9H7"/>
    <dbReference type="OrthoDB" id="10043580at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027911">
        <property type="entry name" value="DUF4604"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040219">
        <property type="entry name" value="KIAA1143-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31195">
        <property type="entry name" value="GEO02494P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31195:SF2">
        <property type="entry name" value="GEO02494P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15377">
        <property type="entry name" value="DUF4604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4604" evidence="2">
        <location>
            <begin position="7"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF15377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5082273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="131" mass="15102" checksum="D58A1154E0AEF984" modified="2022-05-25" version="1">MSRKKHNIAYIKPEEPKFIRDLKAQIGFKEGPDVNTKRQELSEGEEEDFEDRGEEKPQVVVLSKEHLTAEEADEFQKKKDLEEANAPADLSKRIIFNRKAKPEADVLDQPPPKKSKSKKPKLVLSFDDEDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H9L2</accession>
    <name>A0A8J2H9L2_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">EGF-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS3829</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5083402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H9L2"/>
    <dbReference type="OrthoDB" id="504708at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006149">
        <property type="entry name" value="EB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39069">
        <property type="entry name" value="ECDYSONE-INDUCIBLE GENE E1, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39069:SF8">
        <property type="entry name" value="FI17111P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01683">
        <property type="entry name" value="EB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="2">
        <location>
            <begin position="122"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="2">
        <location>
            <begin position="212"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="2">
        <location>
            <begin position="324"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="2">
        <location>
            <begin position="398"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="2">
        <location>
            <begin position="489"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="2">
        <location>
            <begin position="582"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="2">
        <location>
            <begin position="618"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="2">
        <location>
            <begin position="757"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="2">
        <location>
            <begin position="839"/>
            <end position="881"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="2">
        <location>
            <begin position="977"/>
            <end position="1011"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="2">
        <location>
            <begin position="1051"/>
            <end position="1093"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5083402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="1203" mass="135340" checksum="8650AEDAFCF506E2" modified="2022-05-25" version="1">MTMVPLVNEIRMFAHSFISISSGVVISLILFISEANGITNWSSNQCAQYNHECDPHSLHPCCGSILSCKLKESTNEFICGEKTKLGASCVSDVDCNEITHAKCSREKKCVCRANNLRFSETYCAPLLGEFCWKNETCVTRNSLCIDNECRCRENYSASDGHCLPVVGSLRCSYDSDCARIRFAKCSKNNNCVCSLNTAVINNTTCESLLVNYCTTHSDCQPINSICKNNKCQCMPRYVAVNGNQCIQSHLGMSCTNDDFCKDSYLVNQGAYISSLDTIYPPRDECRVKNANCLYNTCWYNSTKGFSGKFCTQDENCYGSLIGEGCSDDKDCQPYFSRCFHGRCQCKDDYSFYSIYNCRPKFLDQDCRDNADCSAIINAECKNFKCACKINYGKFDEMACFSLLGNSCTINTECIVNNSVCSDKVCKCRKDYMPLSNHKCLSKILKQECITDYDCQTIEFSYCSEQSRCTCNQNYVALNETKCAALLGEYCSDDNPCWGANTLCHDNKCNCKQHYKDNFNYQCVPSVYLGESCENNDDCMMIQHAQCSTNKKCFCQEAYIAVNARACKALLDALGKQCNELEDCSIILNSVCSSNGICICAPNYFAFSKYLCVPTINSHCSSDKECMSGGFRCVDSKCQCIHGYTAISADRCVKTNSLYSCNETSECSDSWHWNCASNGKCVCHLDNFALNNSTCLPLLNGYCWKDNQCLAENSVCIDYRCGCNPNHVQAASNLCHAKCSTEKKCDCRANNLRLNETYCAPSLGGLCWKNETCVTRNSLCIDNECRCRKNYSASEDQCLPVIGSLRCRYDRDCARMRFAKCSKNKYCVCSLNTAVINNTSCESLLVNYCTTHSDCQPINSICNNNKCQCRPEYVAVNGNQCIRPELGMSCTNDDFCKVLISNTICTENKTCICDQDSYLVNQGAYISSLDTIYPPRDECRVKNANCLYNTCWYNSTKGFSGKFCTQDENCYGSLIGEDCSDDKDCQPYFSRCFHGRCECKDDYSFYSIYNCRPKFLDQDCRDNADCSAIINAECKNFKCACKINYGKFDEIACFSLLGNKCTINTECIVNNSVCSDKVCKCRKDYMPLSNHKCLSKILKRECITDYDCHTIKFSSCSEQSKCTCNQKYVALDETKCAALLGEYCSDDNSCWGANTLCHDNKCCCKQHFKDNFNYQCVPSKYMFAYLLFIIFDGNISTSVSRRIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H9L8</accession>
    <name>A0A8J2H9L8_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">deoxyhypusine synthase</fullName>
            <ecNumber evidence="5">2.5.1.46</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HICCMSTLAB_LOCUS4117</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[eIF5A protein]-L-lysine + spermidine = [eIF5A protein]-deoxyhypusine + propane-1,3-diamine</text>
            <dbReference type="Rhea" id="RHEA:33299"/>
            <dbReference type="Rhea" id="RHEA-COMP:10143"/>
            <dbReference type="Rhea" id="RHEA-COMP:10144"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57484"/>
            <dbReference type="ChEBI" id="CHEBI:57834"/>
            <dbReference type="ChEBI" id="CHEBI:82657"/>
            <dbReference type="EC" id="2.5.1.46"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; eIF5A hypusination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the deoxyhypusine synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.46" evidence="5"/>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5084488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H9L8"/>
    <dbReference type="OrthoDB" id="294378at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034038">
        <property type="term" value="F:deoxyhypusine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.910.10:FF:000001">
        <property type="entry name" value="Probable deoxyhypusine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.910.10">
        <property type="entry name" value="Deoxyhypusine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002773">
        <property type="entry name" value="Deoxyhypusine_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036982">
        <property type="entry name" value="Deoxyhypusine_synthase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00321">
        <property type="entry name" value="dhys"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11703">
        <property type="entry name" value="DEOXYHYPUSINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11703:SF0">
        <property type="entry name" value="DEOXYHYPUSINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01916">
        <property type="entry name" value="DS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0386">Hypusine biosynthesis</keyword>
    <keyword evidence="7" id="KW-0520">NAD</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAG5084488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="402" mass="44999" checksum="C8285E4408582952" modified="2022-05-25" version="1">MKKSQQKERNQNSSKILLNFINNKIMDSQAINDDVLTSSKNAVLMSSVPLPGDILQIQGYDWNKGIDYHNLFESYKLSGFQATNFGLGVDEIKKMMDCKKIPLSVDQIDSFEQDEFIKRQSSCTMFLGYTSNMVSCGVRESIRFLVQHKMVDCIVTTAGGVEEDLIKCLAPTYLGKFEYDGKNLRDKGLNRIGNMIVPNSNYCLFEDWLMPKLDKMLKDQEEKGMLWSPSKIITRLGEEINNEESICYWAAKNKIPIFSPALTDGSLGDMMYFHSFKNPGLVVDILSDLKRLNTIAVKAINTGIIIIGGGVIKHHICNANLMRNGADFAVFLNTASEFDGSDSGARPDEAVSWGKIRKTATPVKIYAEASLIFPLLVGETFAREFHLAKNSSTSDTEEITKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HB63</accession>
    <name>A0A8J2HB63_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS5679</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5090563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HB63"/>
    <dbReference type="OrthoDB" id="6773055at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5090563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="111" mass="12947" checksum="F42513E18188A9FE" modified="2022-05-25" version="1">MINIKFPISLKDVAKFGKLNKLKINVYGIEIEIVDVKNNQTNKSIVRPLYLSNNISDKETIHLLMVESGRCFYDDKNNDNDIKYENLKKFSNSFPLCSYQKFIATFKITNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HBY2</accession>
    <name>A0A8J2HBY2_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS6298</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5092666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HBY2"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5092666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="102" mass="11584" checksum="E80B091F2DC9342F" modified="2022-05-25" version="1">MDKAKSDEYLFGKDLIDNIKSVKVAEKILANPKSNSKTGSSQNKNLNGPRPVGRRSGQYQQGNVGQFRPRLTFRQNQRIPFKQNNQTPRNSVPQGKSKQRNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HBY9</accession>
    <name>A0A8J2HBY9_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to LINE-1 reverse transcriptase homolog (Nycticebus coucang)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS6655</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5093186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HBY9"/>
    <dbReference type="OrthoDB" id="7697944at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47027">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47027:SF20">
        <property type="entry name" value="REVERSE TRANSCRIPTASE-LIKE PROTEIN WITH RNA-DIRECTED DNA POLYMERASE DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="2">
        <location>
            <begin position="357"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5093186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="727" mass="82359" checksum="205E0A746C717B95" modified="2022-05-25" version="1">MSSSPDHGDIASVADKTPSQKSTTQSYLPLSLAPKKATKKGRPSLADLRLRERALSIGDIGELLTGRKRTRDTPGSNQNLDDDTYPQKYLKRSSSSPSLSPVEKEMSNNNTESLEQLPVPEAPNFAEISNQDAFKWMADQFVALFRTNQAQFTHVKKLINNSSTSVVTQLQTLGDKFVGIVEEVHNLKKQQIEINQRLKEVESGKCCSNQNFNNENLTLIASRIEELEKVTAPNSLNQMKGEIKCQLDKLTKIIETQKSMARRQNIIINGFESTNTPEDIANFLANTFSIPKEDCKNIKQSGKTKDCFVVHFEKPEHKALIMRTKKVKLSTLNIFISNDLTPIESQKAFEIRKKLKEEKEKGNNPKGKKTNKVPRKPWEDTNLLAIKASLVRHQKYCRKTSFTLVNLEILRSLKKALKKTRKQNIERYYQNIRDTLARTNKPADFCRAFDSVPHHLLWAKLFKLGISGKIIRTVQAIYEKVNIQLKINGENFKPFDVTEGVLQGGKLSPTLFILYIEDLIDFLDSKGIQGINIGLNYLRTLLFADDAVFFAGSIKEVKKTLCCLEEYFEANKLKVHTEKTQILVCRSSGRIRKKEKDTFQYNDQPIKSVSQYNHLGTIIDSGVKGKFAANEAANKAKVATGTALSILAKAKADSWQARVKIFNSLVAPTMLYGAEIWGLDYLELIDKTQTDYYKKILQLPRNTPGYMIRLETGITHLSITTLKQTWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HCB6</accession>
    <name>A0A8J2HCB6_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to Negr1: Neuronal growth regulator 1 (Rattus norvegicus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS4713</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5088105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HCB6"/>
    <dbReference type="OrthoDB" id="6365338at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032589">
        <property type="term" value="C:neuron projection membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050808">
        <property type="term" value="P:synapse organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00099">
        <property type="entry name" value="IgV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000129">
        <property type="entry name" value="CLUMA_CG018772, isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013106">
        <property type="entry name" value="Ig_V-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037448">
        <property type="entry name" value="Zig-8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23279:SF13">
        <property type="entry name" value="DEFECTIVE PROBOSCIS EXTENSION RESPONSE 21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23279">
        <property type="entry name" value="DEFECTIVE PROBOSCIS EXTENSION RESPONSE DPR -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07686">
        <property type="entry name" value="V-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035228667" evidence="1">
        <location>
            <begin position="19"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="2">
        <location>
            <begin position="41"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="2">
        <location>
            <begin position="144"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5088105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="234" mass="26219" checksum="DC3C12D860E78BFA" modified="2022-05-25" version="1">MKSVLFTLGLLFVSPGGCIDNNHGDNSKDIEFDFDPLDRGPYFDVAASHNVTALVGKSALLRCRVRNLGDRTVSWVRHRDIHLLTVGTDTYTSDQRFVASHFPRTEDWTLEVKYPQLRDSGTYECQISTTPPIGYSMHLSVVEPVTTVIGEPEMYINRGSTMNLTCVVEFSPEPPPAIFWTHNEKEINYDSPRGGVSVITEKGEHPAAMQHGGQLRLANPPFVILLSILIKEYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HCF0</accession>
    <name>A0A8J2HCF0_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="4">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HICCMSTLAB_LOCUS7191</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 15">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SINA (Seven in absentia) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="4"/>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5093865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HCF0"/>
    <dbReference type="OrthoDB" id="941555at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031624">
        <property type="term" value="F:ubiquitin conjugating enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000050">
        <property type="entry name" value="E3 ubiquitin-protein ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000063">
        <property type="entry name" value="E3 ubiquitin-protein ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004162">
        <property type="entry name" value="SINA-like_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049548">
        <property type="entry name" value="Sina-like_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013010">
        <property type="entry name" value="Znf_SIAH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45877">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE SIAH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45877:SF2">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE SINA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21362">
        <property type="entry name" value="Sina_RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21361">
        <property type="entry name" value="Sina_ZnF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49599">
        <property type="entry name" value="TRAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51081">
        <property type="entry name" value="ZF_SIAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="11">
        <location>
            <begin position="38"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="domain" description="SIAH-type" evidence="12">
        <location>
            <begin position="90"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAG5093865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="147" mass="15782" checksum="129139B12EE83014" modified="2022-05-25" version="1" fragment="single">MSQLNISSGKRGRGVASTSAAAVSASNSSTDLASLFECPVCFEYVLPPILQCQSGHLVCSNCRPKLTCCPTCRGPLGNIRNLAMEKVASNVMFPCKYSTSGCTVSMVHIEKPDHEDACEFRPYSCPCPGASCKWQGSLEEVMPHLVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HCS1</accession>
    <name>A0A8J2HCS1_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="18">Similar to RyR: Ryanodine receptor (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">HICCMSTLAB_LOCUS7171</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Sarcoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5093845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="300855at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034704">
        <property type="term" value="C:calcium channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042383">
        <property type="term" value="C:sarcolemma"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033017">
        <property type="term" value="C:sarcoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005790">
        <property type="term" value="C:smooth endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030018">
        <property type="term" value="C:Z disc"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005219">
        <property type="term" value="F:ryanodine-sensitive calcium-release channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0014808">
        <property type="term" value="P:release of sequestered calcium ion into cytosol by sarcoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006941">
        <property type="term" value="P:striated muscle contraction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23278">
        <property type="entry name" value="beta-trefoil_MIR_RyR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12877">
        <property type="entry name" value="SPRY1_RyR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12878">
        <property type="entry name" value="SPRY2_RyR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12879">
        <property type="entry name" value="SPRY3_RyR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.920:FF:000069">
        <property type="entry name" value="Ryanodine receptor 44F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000017">
        <property type="entry name" value="ryanodine receptor isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.30:FF:000002">
        <property type="entry name" value="ryanodine receptor isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.920:FF:000002">
        <property type="entry name" value="ryanodine receptor isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.920:FF:000003">
        <property type="entry name" value="ryanodine receptor isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.490.160:FF:000003">
        <property type="entry name" value="Ryanodine receptor, isoform E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.80.10.50:FF:000022">
        <property type="entry name" value="Ryanodine receptor, isoform E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.80.10.50:FF:000021">
        <property type="entry name" value="Ryanodine receptor, isoform F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.490.160">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.30">
        <property type="entry name" value="IP3 receptor type 1 binding core, RIH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014821">
        <property type="entry name" value="Ins145_P3_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036300">
        <property type="entry name" value="MIR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016093">
        <property type="entry name" value="MIR_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013662">
        <property type="entry name" value="RIH_assoc-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000699">
        <property type="entry name" value="RIH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013333">
        <property type="entry name" value="Ryan_recept"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015925">
        <property type="entry name" value="Ryanodine_IP3_receptor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003032">
        <property type="entry name" value="Ryanodine_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009460">
        <property type="entry name" value="Ryanrecept_TM4-6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048581">
        <property type="entry name" value="RYDR_Jsol"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035910">
        <property type="entry name" value="RyR/IP3R_RIH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035761">
        <property type="entry name" value="SPRY1_RyR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035764">
        <property type="entry name" value="SPRY2_RyR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035762">
        <property type="entry name" value="SPRY3_RyR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46399">
        <property type="entry name" value="B30.2/SPRY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46399:SF8">
        <property type="entry name" value="B30.2_SPRY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08709">
        <property type="entry name" value="Ins145_P3_rec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02815">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08454">
        <property type="entry name" value="RIH_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06459">
        <property type="entry name" value="RR_TM4-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01365">
        <property type="entry name" value="RYDR_ITPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21119">
        <property type="entry name" value="RYDR_Jsol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02026">
        <property type="entry name" value="RyR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00795">
        <property type="entry name" value="RYANODINER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00472">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100909">
        <property type="entry name" value="IP3 receptor type 1 binding core, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82109">
        <property type="entry name" value="MIR domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50919">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0107">Calcium channel</keyword>
    <keyword evidence="3" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="13" id="KW-0407">Ion channel</keyword>
    <keyword evidence="10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="12" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="11 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-0675">Receptor</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0703">Sarcoplasmic reticulum</keyword>
    <keyword evidence="5 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="4415"/>
            <end position="4435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="4605"/>
            <end position="4625"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="4692"/>
            <end position="4720"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="4846"/>
            <end position="4868"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="4922"/>
            <end position="4945"/>
        </location>
    </feature>
    <feature type="domain" description="MIR" evidence="17">
        <location>
            <begin position="94"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="B30.2/SPRY" evidence="16">
        <location>
            <begin position="576"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="domain" description="B30.2/SPRY" evidence="16">
        <location>
            <begin position="1030"/>
            <end position="1213"/>
        </location>
    </feature>
    <feature type="domain" description="B30.2/SPRY" evidence="16">
        <location>
            <begin position="1445"/>
            <end position="1669"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1373"/>
            <end position="1456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="2278"/>
            <end position="2298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="2919"/>
            <end position="2946"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="3577"/>
            <end position="3602"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="3884"/>
            <end position="3905"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="4498"/>
            <end position="4538"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="4651"/>
            <end position="4682"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="1426"/>
            <end position="1440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="2278"/>
            <end position="2287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="3887"/>
            <end position="3904"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="4501"/>
            <end position="4510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="4512"/>
            <end position="4522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="4670"/>
            <end position="4682"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="CAG5093845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="5056" mass="572946" checksum="D40C7E821223F153" modified="2022-05-25" version="1">[encoded data, 5056 characters]</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HD28</accession>
    <name>A0A8J2HD28_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS7647</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5095314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HD28"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5095314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="126" mass="14593" checksum="39CA5C9BD15306BE" modified="2022-05-25" version="1" fragment="single">FFEHLNKEKEVEEHMYGDAITGMYVRCTIGIDRKPKYKLTGSLCAFSANVNSRRNYCDSDSSLGKASVAIRLFNKPEQFLLREEVCSVKKLKVFNIRRNIIESAQYKFLLSPLSIRLLLSSKHRSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HDC6</accession>
    <name>A0A8J2HDC6_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similar to ItgaPS4: Integrin alpha-PS4 (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS7162</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5093836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HDC6"/>
    <dbReference type="OrthoDB" id="5573735at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009897">
        <property type="term" value="C:external side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008305">
        <property type="term" value="C:integrin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005178">
        <property type="term" value="F:integrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033627">
        <property type="term" value="P:cell adhesion mediated by integrin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098609">
        <property type="term" value="P:cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007160">
        <property type="term" value="P:cell-matrix adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007229">
        <property type="term" value="P:integrin-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.130">
        <property type="entry name" value="Integrin alpha, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013519">
        <property type="entry name" value="Int_alpha_beta-p"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000413">
        <property type="entry name" value="Integrin_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028994">
        <property type="entry name" value="Integrin_alpha_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23220">
        <property type="entry name" value="INTEGRIN ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23220:SF83">
        <property type="entry name" value="INTEGRIN ALPHA-PS3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01185">
        <property type="entry name" value="INTEGRINA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00191">
        <property type="entry name" value="Int_alpha"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69318">
        <property type="entry name" value="Integrin alpha N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2" id="KW-0401">Integrin</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5093836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="337" mass="36970" checksum="30C5795AC79EB1EA" modified="2022-05-25" version="1" fragment="single">MHAINLLTLLVTFLTYTSIISSYNIVVKNAIVARNRDFSYFGYTVLLRKPWMIVGAPKANFTSIPRGLQAPREPGASYRCNLKSIKCEQFRPSDVNDESGFITQVNYNSLVKKAYGWFGASMALDENDDLITVCAPRTILSIFSILDKHISMHGVCYSGKISSGNLQLEDNFKSHDFLSSFWYNSLHGFSIHYSKAINNKEKVRMITGAPKHEVIGTVQIKGQKTSATLPTTDDLTQFGYSVTSGRFFNKSKVLFAAGAPGWNLIGQVGILDSGVDSLKLIMSIKGQIVGEYFGGSLAVGDVNNDGFLEPPIIIDGPKEDSCFGYSVTSGDIDSDGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HDK8</accession>
    <name>A0A8J2HDK8_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Similar to exd: Homeobox protein extradenticle (Anopheles gambiae)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HICCMSTLAB_LOCUS7559</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5095138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HDK8"/>
    <dbReference type="OrthoDB" id="4187154at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990837">
        <property type="term" value="F:sequence-specific double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005542">
        <property type="entry name" value="PBX_PBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050224">
        <property type="entry name" value="TALE_homeobox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11850">
        <property type="entry name" value="HOMEOBOX PROTEIN TRANSCRIPTION FACTORS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03792">
        <property type="entry name" value="PBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51978">
        <property type="entry name" value="PBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 7" id="KW-0371">Homeobox</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PBC" evidence="6">
        <location>
            <begin position="1"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="74"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="272"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="79"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="281"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAG5095138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="298" mass="32564" checksum="25EC7F0A33CEA845" modified="2022-05-25" version="1">MYCATCDVDIEENKNVRVIQVASISTLAGRRSTRKMLTAILSLRNTQEEEPPDPQLMRLDNMLIAEGVAGPEKGGGAGAAASASAASAAGPPGQPDNAIEHSDYRAKLAQIRQIYHQELEKYEQACNEFTTHVMNLLREQSRTRPITPKEIERMVQIIHKKFSSIQMQLKQSTCEAVMILRSRFLDARRKRRNFTAFAGASPYSMGGASQGTSTPMMSPAPPGGPQDMAGYGMGINGSDYGSQPYNDGSMGYDPMHQGKGLAAGAGWMHREAMPEFPPLHDSADSDSDSRENEKRPRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HDL8</accession>
    <name>A0A8J2HDL8_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Similar to Tmprss7: Transmembrane protease serine 7 (Rattus norvegicus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HICCMSTLAB_LOCUS7962</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5095946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HDL8"/>
    <dbReference type="OrthoDB" id="10002959at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050127">
        <property type="entry name" value="Serine_Proteases_S1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24264:SF54">
        <property type="entry name" value="PEPTIDASE S1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24264">
        <property type="entry name" value="TRYPSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="1 5" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0720">Serine protease</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <feature type="domain" description="Peptidase S1" evidence="4">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAG5095946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="91" mass="10034" checksum="9D9536B3EC18FDF0" modified="2022-05-25" version="1">MFCKKLMSRLFLMNGVRGGSELPDEEKQSMMFSCALVTKKGDSGGPLTMAVEGRHVLIGLVSWGIGCGREHLPGVYTNIQKFVPWIDKVMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HDY2</accession>
    <name>A0A8J2HDY2_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS5605</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5090370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HDY2"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5090370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="116" mass="13456" checksum="66E8ED54B49DE71B" modified="2022-05-25" version="1">MSLRSQLRLNHRFTVGEKSNIDMKTCHKKDIELNDILEAIGCNEHLPIQIMHSVAEIQCTNYQNDRITINSIIMEPSNGGPLFYLCWMIAILIIIQKFLQSKMVTVTIFDYSSYNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HEQ3</accession>
    <name>A0A8J2HEQ3_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Transmembrane protease serine 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HICCMSTLAB_LOCUS6977</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Extracellular space</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase S1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5093642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HEQ3"/>
    <dbReference type="OrthoDB" id="6755574at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000068">
        <property type="entry name" value="transmembrane protease serine 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000036">
        <property type="entry name" value="Trypsin beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050430">
        <property type="entry name" value="Peptidase_S1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24276:SF96">
        <property type="entry name" value="PEPTIDASE S1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24276">
        <property type="entry name" value="POLYSERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 8" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0720">Serine protease</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <feature type="domain" description="Peptidase S1" evidence="7">
        <location>
            <begin position="1"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG5093642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="209" mass="23176" checksum="783E0A0CD3F6F7C9" modified="2022-05-25" version="1" fragment="single">VSLTLIGLHICGGSIIGYKYVLTAAHCFVNLTHPGKKIQLDILGVRSHTIDSQYGGQLHGVERLWIHRYYNSFDPASLHDVAILKLKRPVQFDAEQTWIALQQYPIGSGHSVLSVGWGYTEDHPRLTSRKLKKVSLNTMEASVCENYLRDRVWMGRICTVAPRGQGLCNGDSGGPLITRDGKLVGLVSWGILCALGNPDVFTQVPLYYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HEW7</accession>
    <name>A0A8J2HEW7_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similar to jockey\pol: RNA-directed DNA polymerase from mobile element jockey (Drosophila funebris)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS8438</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5096893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HEW7"/>
    <dbReference type="OrthoDB" id="7989680at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47027">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47027:SF20">
        <property type="entry name" value="REVERSE TRANSCRIPTASE-LIKE PROTEIN WITH RNA-DIRECTED DNA POLYMERASE DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5096893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="329" mass="38123" checksum="9E693C9F1E31A516" modified="2022-05-25" version="1" fragment="single">MAYAPNDQQGTVNSPTLFNIFTSHILNACKLNHNNNTYSIAYADDLIIYVAAKYPKELKERLETIVNKINNLYARWNLRVGPGKCETIVFRKPAMFVTKSKRINNDRFIIETFHPETRENIKVPTVNSVKYLGMDIDYLAKCNTHLPGLDSQLKKARNSYRSLGRLFHNKFITPRAKIICYQLLVRPLLTYAAPVCWNIGAAHMEKLRMFERSCLRTALVDKQGRERVSNKELYNAAKIPRIDNHRIKLTRDYYSKLNIINNELIKKLKYVNGDILTNAQKGLLQPQAFTTLDKLGIIQDSMNIPILYHKSRHKSNKVLDLRNFKNKPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HEZ9</accession>
    <name>A0A8J2HEZ9_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Serine protease trypsin-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HICCMSTLAB_LOCUS6826</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5093436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HEZ9"/>
    <dbReference type="OrthoDB" id="9448935at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000006">
        <property type="entry name" value="Serine proteinase stubble"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24252">
        <property type="entry name" value="ACROSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24252:SF7">
        <property type="entry name" value="HYALIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 7" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0720">Serine protease</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035194249" evidence="5">
        <location>
            <begin position="18"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="6">
        <location>
            <begin position="40"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAG5093436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="290" mass="31938" checksum="EB799F8464B67205" modified="2022-05-25" version="1">MACVIFVFIGVLTPIFAVEYNNLADVPCGVASPISRMPKVVGGENALPREFPWLVSITRKGGHYCGGSIINSKFILTAAHCLCSGTDSIPARQFRVTLGEYNLREPEIPAAIIENVQRVIVHPEHTCGQYVNDIAILELESPITWSASVQPACFPTVQGEPGYRLYENEPAIAAGWGWLGEDRSKYKRTDVLQKVAVNVVKNEICKDWYKVEGKKTRVEPQQMCAGYESGGRDACWADSGGPLMVKNFLKKEGTIVVGIVSSGVGCARPRLPGIYTRISEYMPWIIRETN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HGF7</accession>
    <name>A0A8J2HGF7_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Histidine decarboxylase</fullName>
            <ecNumber evidence="4">4.1.1.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HICCMSTLAB_LOCUS8201</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the group II decarboxylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.22" evidence="4"/>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5096421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HGF7"/>
    <dbReference type="OrthoDB" id="639767at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004398">
        <property type="term" value="F:histidine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042423">
        <property type="term" value="P:catecholamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001694">
        <property type="term" value="P:histamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006548">
        <property type="term" value="P:L-histidine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06450">
        <property type="entry name" value="DOPA_deC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1340.10:FF:000001">
        <property type="entry name" value="Histidine decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000025">
        <property type="entry name" value="Histidine decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000018">
        <property type="entry name" value="Histidine decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1340.10">
        <property type="entry name" value="dopa decarboxylase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010977">
        <property type="entry name" value="Aromatic_deC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002129">
        <property type="entry name" value="PyrdxlP-dep_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021115">
        <property type="entry name" value="Pyridoxal-P_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11999">
        <property type="entry name" value="GROUP II PYRIDOXAL-5-PHOSPHATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11999:SF68">
        <property type="entry name" value="HISTIDINE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00282">
        <property type="entry name" value="Pyridoxal_deC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00800">
        <property type="entry name" value="YHDCRBOXLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00392">
        <property type="entry name" value="DDC_GAD_HDC_YDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0127">Catecholamine biosynthesis</keyword>
    <keyword evidence="6" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="8" id="KW-0456">Lyase</keyword>
    <keyword evidence="7 10" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="10">
        <location>
            <position position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00039946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR602129-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAG5096421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="684" mass="76293" checksum="D4A957F815757501" modified="2022-05-25" version="1">MVDYIANYLETIRTRRVYPAVSPGYLRNILPISAPVNGEPWENIFQDIEKCIMPGVTHWQSPHMHAYFPALNCPASLLADMLADAINCLGFTWASSPVCTELETVVMNWLGEMIGLPEEFLHCPEGSGGGVIQTTASESTLICLLAARSRALRAIQENDPDKSPGEINSHLVAYCSDQAHSSVEKAGLIGLVQMRYIESDDKLSMRGDMLMEAIIRDREAGLVPFFVCATLGTTGACSFDNLSEIGPICEKNCIWLHIDAAYAGSAFVCPEFRGWLRGVEFADSIAFNPSKWLMVHFDCTAMWVKNSQALHRTFNVDPLYLKHENSGLAIDYMHWQIPLSKRFRALKLWFVIRNYGITGLQKHIREGVRLAKKFEALVLGDSRFEIPAVRHLGMVVFRLRGENSLTERLLKKMNSNGRVHCVPASLHGKYVIRFTVTSTNTTNEDILRDWAEIKTTASEILSTATVSPARVKVSLAETRQKNENFGSSLLLANSPMSPKIVNGSFAAIYDTADVFNDCMKAFGQLRLEPRDSPAMRRRIRGILMSGKQFSLDSRMDLVQGYASCGRPLSEPSTTLPLMKEDEDYNGKNDSNFSIDKTDKPIGIYYDNTTSKSNSDDSIGVNNHQVSFQTNAENTMMNFEINELYVGKTITKSETIGGISGLINTTFTIQSQSDETMNNKDLKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HGN6</accession>
    <name>A0A8J2HGN6_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Similar to EHMT1: Histone-lysine N-methyltransferase EHMT1 (Homo sapiens)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HICCMSTLAB_LOCUS7556</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5095132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HGN6"/>
    <dbReference type="OrthoDB" id="616263at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046974">
        <property type="term" value="F:histone H3K9 methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002039">
        <property type="term" value="F:p53 binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20905">
        <property type="entry name" value="EHMT_ZBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10543">
        <property type="entry name" value="SET_EHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.270.10:FF:000005">
        <property type="entry name" value="Euchromatic histone-lysine N-methyltransferase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043550">
        <property type="entry name" value="EHMT1/EHMT2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047762">
        <property type="entry name" value="EHMT_CRR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007728">
        <property type="entry name" value="Pre-SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46307">
        <property type="entry name" value="G9A, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46307:SF4">
        <property type="entry name" value="G9A, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21533">
        <property type="entry name" value="EHMT1-2_CRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05033">
        <property type="entry name" value="Pre-SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00468">
        <property type="entry name" value="PreSET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50867">
        <property type="entry name" value="PRE_SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="2" id="KW-0158">Chromosome</keyword>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="repeat" description="ANK" evidence="5">
        <location>
            <begin position="711"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="5">
        <location>
            <begin position="744"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="5">
        <location>
            <begin position="777"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="5">
        <location>
            <begin position="847"/>
            <end position="879"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="5">
        <location>
            <begin position="880"/>
            <end position="912"/>
        </location>
    </feature>
    <feature type="domain" description="Pre-SET" evidence="8">
        <location>
            <begin position="1002"/>
            <end position="1066"/>
        </location>
    </feature>
    <feature type="domain" description="SET" evidence="7">
        <location>
            <begin position="1069"/>
            <end position="1186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="48"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="217"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="456"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="632"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="13"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="75"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="119"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="166"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="236"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="295"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="307"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="328"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="406"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAG5095132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="1235" mass="138401" checksum="514EC719A16BEE93" modified="2022-05-25" version="1">MSEEKDMSKEGCPEEELEDDDMATINAVGDKVSIQKILEGMTNEFNRSIHNNSAAKSIEEQQQDDNSSKIGTDAEYLDEEDINNDNDDDNDQINDIGLDKESESVDINSINAEDHQQIEEEEDDVEAEAEPQEEEEEEEEEEEEGEGEEQEEVGLVESLEDPEIIELPRAETKKDNIPRIVLTFRTIDETTNDGRKTKISSCASNLSLVPDELREIASIEPAVVDQEKKDQEDQEGSSGVTTGDNQEPSTRKRRRRTRFRAFSDSTEETPSLKRSARRLCKESGKSTVLESAMAIKEKSYSTEENKKRKYTKPGRPRRANVKEVKVVNSYTEHNNYSDNSINDSKVSSPGDSTANDTSLIEDPQNSSVEYEGMPKLSPMVKDSPAKIETVDDSSASDVDKPFLKPAGRKKDRGRPRNNSYVRKIIKNDSFEDGSSAAEAGKNNDYPEEYHVPMKRTRRTMVPSPSPAEGQASKPESSAVFSETYEQSMICLCQVRSQLYVTITGSGTPLFCTAIDSIDNRLIGCCNEVDGNDVAMRRPSTRVPFIILCRAHKERLLRHNCCPSCGLFCTQGKFVQCITGHQFHRDCEVYVNKKPVCPHCANETSNVDVLITMTGSRKPVYIPTRRKFSKLPSAKMSLPGKGDNTKLAERPPSPLVKPEDIKIPEVTVNANERPERFTIISLYTSVKNGDLDKLVNVLACGYNANHSFREYSHRTALHIAADRGHLGCVHALVQAGAQLDVLDKNQLTPLMLAAMEGKTEIVRYLVRVGADVTLKGEDGMTALHMAAKSGHLESCKIILSECKVPRTLVDSVDDGGWTSLIWACEFCHTDVARFLIEKKCDPLIRDAEQNIALHWSAYSGSSEITEMLLNEGCDVNAVNVHGDTPLHIAARQDQYAVSVLLLARGAKVSEVNAAGETAINCCTTDGDTMAALRLNAKVIELSENMWEKTTRILTNDISRGKESNPIQCVNGFDSEDKPTDFLYVVENCFTSNINVDRTITSLQSCHCEDNCSSEKCLCGNISLRCWYDEEGKLIPEFNYADPPMLFECNQACACNRITCNNRVVQHGLTQRFQLFRTKGKGWGLRSLRHIPKGSYVCEYVGEIISDSEADHREDDSYLFDLDNRDGETYCIDARRYGNLARFINHSCAPNLLPVRVFVEHQDLHFPRIAFFANRNIEADEELGFDYGEKFWIIKYKSFTCTCGALSCRYSEKTIQVTLDNYRKKIQQEEILAGQLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HH37</accession>
    <name>A0A8J2HH37_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Similar to C12orf4: Protein C12orf4 (Homo sapiens)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS10143</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5101070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HH37"/>
    <dbReference type="OrthoDB" id="415359at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019311">
        <property type="entry name" value="Fy-3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16525">
        <property type="entry name" value="PROTEIN C12ORF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16525:SF0">
        <property type="entry name" value="PROTEIN C12ORF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10154">
        <property type="entry name" value="Fy-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5101070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="551" mass="63018" checksum="A0D101DCFD4227C6" modified="2022-05-25" version="1">MSEDYQEKIFLFQFPTCTTNQNYTLEIPLKIPYNGSIKELTYRIMSAFKLPCYVEKDLLNSLEQTVKNWTQNYYDERDEKLIKSARSGEIDLEKIIKNWEKAYREKTAEYAQPMGTTDEELFAAAYHKLVHSPSLEPILQAEHKYGKDVTDVIHIKNSEYDQLTQKQTEEMRVAVEKLELGSTEKSINEMAARHFEEQSLLQGHWGSRIDALKLEQRRQYRNWIMRLLEEQQTNMLPTPVGSPVVPMPFVPETLETVEAKEKIKTSDYPQLEESFTIHLGSQMKQMHNIRILTGDVLDFCRTKSNSASMEPTPQRLQTALGLYSNDLCGIVVLSDNHLGSYSGITKELSTICQLTTEFHFPSMEEQLEKIRDDVKEAVAWRQAHHKDTNDLPVKKSTLSKSLQTGDVFITRHSNLAQVHVVFHMVINDSLRSGDINSRHPAILGLRNILKTACCNDVTTLTIPVLLVHEMTEDMTVAWCTKRAELVYKCVKGFMIEMASWGGAELKNLQFLVPKGMSEEVFGTLATMLPSIFRVSNPLVFKVSNAPVTPKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HH50</accession>
    <name>A0A8J2HH50_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Similar to Arp2: Actin-related protein 2 (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HICCMSTLAB_LOCUS10173</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the actin family. ARP2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5101100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HH50"/>
    <dbReference type="OrthoDB" id="10251209at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000050">
        <property type="entry name" value="Actin, alpha skeletal muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000005">
        <property type="entry name" value="Actin-related protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004001">
        <property type="entry name" value="Actin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00432">
        <property type="entry name" value="ACTINS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG5101100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="311" mass="34991" checksum="66C2475F0DE17283" modified="2022-05-25" version="1">MDNQGRKVIVCDNGTGFVKCGYAGANFPAHIFPSLVGRPIIRAVNKIGDIDVKQDLCVRDLMVGDEASKLRSLLEISYPMQNGIVRNWEDMCHVWDYTFGPEKMNIDPHECKIIGVVVDSGDGVTHICAVYHECAPCHLIKRLDVAGRDITMYLIKLLLLRGYAFNHSADFETVRMMKEKLCYIGYNIETEEKLAVETTVLVESYTLPDGRVIKVGGERFAAPEALFQPHLINVEAPGIAELVFNTIQSAAIDIRSELYKHIVLSGGSTMYPGLPSRLEQLTKNRDSFWITKEEYEERGLKVLDKLTTYDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HHP3</accession>
    <name>A0A8J2HHP3_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to ASPSCR1: Tether containing UBX domain for GLUT4 (Homo sapiens)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS7901</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5095824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HHP3"/>
    <dbReference type="OrthoDB" id="440781at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012506">
        <property type="term" value="C:vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042593">
        <property type="term" value="P:glucose homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16105">
        <property type="entry name" value="Ubl_ASPSCR1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17075">
        <property type="entry name" value="UBX1_UBXN9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16118">
        <property type="entry name" value="UBX2_UBXN9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021569">
        <property type="entry name" value="TUG-UBL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059238">
        <property type="entry name" value="UBX1_UBXN9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001012">
        <property type="entry name" value="UBX_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46467">
        <property type="entry name" value="TETHER CONTAINING UBX DOMAIN FOR GLUT4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46467:SF1">
        <property type="entry name" value="TETHER CONTAINING UBX DOMAIN FOR GLUT4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11470">
        <property type="entry name" value="TUG-UBL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00789">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50033">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UBX" evidence="2">
        <location>
            <begin position="353"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="160"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="480"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="179"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="231"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="483"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="495"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5095824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="520" mass="57990" checksum="136D046E0B508AF9" modified="2022-05-25" version="1" fragment="single">PNGRRQNVKITPNTTILQVLEEVCQKQGYASRKWDLKHMNTILDVNSIFRFTGLPNNAQLEMTPRPNERAISVVTIGIQLENGQRLMGDFSPVTTLSEIINALCSNEQADDTVIIYMHQELHGQDNLQKTTLQSLGLNNGRAMLRLIHRDLNKLNTQAHVAGKLASKPNKPNEKDRGGKNSQKSSGTSVTNQIKKVINDPLALLRSEKSDKGQNKSGGSNKKMAGSGHVLGRAETKTETEVHQPPEMKPAKIIDQVETEADNAMETNQDSHDKIINEPIDFLGERNALVFNQAGAQAVSHEDLPDNFFDLTVDDAKTLLRDAKRQREDIEGAPLRTNAQRQLERNRATLNKLHKYRRTILRIQFPNQMVLQGIFGPLETVQLVKDFVKDYLANPEEDFTLYCTPPKKNLTPQSRLIDENLVPSAIIYYSGSSELKADLNTKLVDPKVASVHAIKSRIAMTRDEPNNSGDSNANLESDNVQLRSSISNESVPSSSGAEGSNVSNSDRIKNYTPKWFKNAFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HHV9</accession>
    <name>A0A8J2HHV9_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">2',5'-phosphodiesterase 12</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Mitochondrial deadenylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">HICCMSTLAB_LOCUS8581</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5097179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HHV9"/>
    <dbReference type="OrthoDB" id="412787at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004535">
        <property type="term" value="F:poly(A)-specific ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000288">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.10.10:FF:000018">
        <property type="entry name" value="2',5'-phosphodiesterase 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050410">
        <property type="entry name" value="CCR4/nocturin_mRNA_transcr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048821">
        <property type="entry name" value="PDE12-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12121:SF37">
        <property type="entry name" value="2',5'-PHOSPHODIESTERASE 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12121">
        <property type="entry name" value="CARBON CATABOLITE REPRESSOR PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21171">
        <property type="entry name" value="PDE12-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="2',5'-phosphodiesterase 12-like N-terminal" evidence="15">
        <location>
            <begin position="174"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="14">
        <location>
            <begin position="297"/>
            <end position="602"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00072755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00083541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF21171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CAG5097179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="620" mass="70511" checksum="238C65EC81EC8220" modified="2022-05-25" version="1">MQVLNRCVNINYQLNFPILINIKTLFVGQLSSKGVVGPGNTKTFYKMHEAYIRYTSGTEVFDFTFRFSRPDLNIDKQLNFSRKVSENVETFLSRVSSNVTKHMTTKAKKKAKKAKVAPGEEEIKVDHVKEGNIYLSKGDSKLNLDEPCTNFLTDPSELKLVVFDQKYDVKLNAPWIIKMKLPSCLLANFPVYPSEFESMYVDRGLSVFTWHKSVYDEKMKLSWKLIGEGFLYKPSAEDIGSKLKVKCLPRNDRLEGSETEVDSDTLVEAGPGECPFETRHKFTSNKLSGDSFRVTSYNLLADTYADSEYSRAVLFPYCPPYALNIDYRKLLIIKELIGYNSDIMCLQEVDKKIYDNDFLPSLSSVNFDGVFNAKRTTSEGQATLYDTKRFEMLSYKGISMADGIEKNLIFKKTWDKITNENARVRFKDRSTSVLIVTLRSRDNPKEILVVGNTHLYFHPDADHIRLLQAYFALTSCQATADEIRQQYPEHNVTVMLCGDFNSTPVDGVYEFITKNAIPETHKDWTSNSEQVVENVSISHDLALQSACGTPEYTNFTVGFADCLDYIFYETNKLEVSQVIPMPSKEELLLNQAIPSVVFPSDHIAICADLKWHSPSSSVSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HI85</accession>
    <name>A0A8J2HI85_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zinc finger protein Rlf/292/654 TPR repeats domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HICCMSTLAB_LOCUS9892</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5100819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6427254at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057986">
        <property type="entry name" value="TPR_Rlf/292/654"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25580">
        <property type="entry name" value="TPR_Rlf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zinc finger protein Rlf/292/654 TPR repeats" evidence="3">
        <location>
            <begin position="226"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="394"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="513"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="570"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="735"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1079"/>
            <end position="1133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1179"/>
            <end position="1320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1388"/>
            <end position="1428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1850"/>
            <end position="1919"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1935"/>
            <end position="2043"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2682"/>
            <end position="2774"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2885"/>
            <end position="2915"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2929"/>
            <end position="2948"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="3038"/>
            <end position="3079"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="473"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1619"/>
            <end position="1691"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="413"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="439"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="515"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="571"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="773"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="788"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="803"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="866"/>
            <end position="876"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1082"/>
            <end position="1099"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1118"/>
            <end position="1131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1179"/>
            <end position="1219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1229"/>
            <end position="1239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1256"/>
            <end position="1273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1274"/>
            <end position="1303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1310"/>
            <end position="1320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1390"/>
            <end position="1400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1401"/>
            <end position="1413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1414"/>
            <end position="1428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1851"/>
            <end position="1870"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1890"/>
            <end position="1913"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1968"/>
            <end position="1980"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="2015"/>
            <end position="2040"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="2684"/>
            <end position="2695"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="2730"/>
            <end position="2739"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="2753"/>
            <end position="2762"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="2903"/>
            <end position="2913"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="2929"/>
            <end position="2947"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="3056"/>
            <end position="3068"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="3069"/>
            <end position="3078"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25580"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG5100819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="3096" mass="337341" checksum="90DC7832C8ABE0F4" modified="2022-05-25" version="1">MSSHIQKSCVGLEATLSDSKKKYGDKVGALLSAWEHVTNFISTANPEATQSLIEWVHKHTLTLVLRGEWPKLSPATKTHLSVTLQRCASHLVHHPVASRCTALIALVHNPWAHPALDRILNGQPDPEHEEDRCEDIAVNLAAACVRSLRRSDRLRSLSDLHHVHFMIDVYIVLLYKLKRTQDIFAQLKLMDLNDGLELVQRLSGEKPMKYGTARVWRNSIKAAELVAQYLVTAGMVRPVNETSASVLEQILNSWACLHVKLKATDPNLPGMIRKLIENAESAQHIYLFCAVLLKHFGDSIKPLAIELYIRALTADMNELETQKIKSDIDNVRETAKRLSTQFLKLADVVNNNIGIARECVLTAFSLNPTRACYDKICELAIACGKVTRLESQPQIHTLDEETKEDEENERLSTTPVEVATTTSTPVTITTTTLNKMDDNSQSDNNKTNNNTTIATNSIIESQFENTTDSNIKIDLKEGNNKQTQQQSQNYNNNNSKCTDQLLKKLLNSPVQCCHSNSSSSSSSSSSSSNINTDKKSDKCVVNNFKKDSNSEGSLDEICLNCNNYKGMNVDSNTNSNNSSSNNTSSNTGNNNSNKNKSSTESGKSVIVNKDHRTLDALILIKGEVVTGSANYDEKSVPNQVLDAEQLGLTPQLCDDLAVVLSSPRYHMLSWVSDWNELSTLCERYLENAQEMRHTNKELKYLNIDYSQFKDWPSEDDSKDVFYGIEKGYEQWADGASDTSEQYGSFQPAGSYKRSSTRRSLDDSSDSDSGSILRVRRTGRQRKIHRLISSESDYDSSSGVKSSSNKHYRNNSYNRRRKSSCVSDTEDTNTQDSQTDSLGSDGCRQDNKINNKPCNNKELTKRSGNNGSNGGIGGNGSSVGKSKLTVDTVSHFHMLVNENMHHTTSTISSGAGSEDVSGSDVSSNDIITLFSADLDENKRETIKGSAFTAVSPIIITKKRSDPAVLKSLRMFRPQNIKKPTPRINQLVPKNILNNNINKNNINNKDNVSGGGNGGNNVGGNITKFAPLLSTLNLNPKIVLTRNNEIDKKLEQTKIKKQPGVLSAGDLSSELLNIQKKMPFTHKNPIHNHHHHHNHHHHHNHNYSSDKNNKSPRGRKPIKSNNNNISNNNNNNNLGKSNYDILAKAVRDSDILAQTVPGLNTLDMMVPPRVQSTVNVVQISRNIPQSPNSGSINSGNTSPRNRTSSIVSSIIQLPGTPSSGGHDSGVGMSPAGQTSPPTRTSVLHDVGEKANQPPDASPTISTNVSATEPDSPHTTSNSNNININNNNNNNNNNNNNNIQRIISRNDSPNKSPSPSTTTTTTVTATTITSTAAITTTVPITTEQLQIVCKPDGTYQLATINPNIITTGQRNLLTLQNLEDDSIGFTRQIQRVSESSSGSGSNSRTNTYERQTVKVSQQPQKPPQQQQQQLQLQNTGLPKFQQAFGKTIYTQSDTTTVATSSTTETITQPMSSIQKTSNLSKAVQTSVLNSQGSVSSGGSSSGINVQSIANIPNLQLSSSGGRQILNIVQNTGSNNTNINTPNASQTITQLVQNTSPGVIYTTHKIPVTITTTTNPSQLNIIPAISHTNSLPGGRPPVVKLNIIRTPLRQQNLAEVIQATINASRIQQQNSQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQRQQTAVRADSLLNSPIEVPNQVSSTTLEQLREFESVLEQVKERSTIQPQLQSSSSTTTTAVQTQTTSQQTQAKQQHQQTAVSALAQQLLISTQTSTNTEFTNNNGGNNSTTTFQQQQEVFPQKVSLTYVNQTTPTTPQKSTNTTTTPVVVVTSYCQPAASPALSITSQSSSSPCVTPAPTSVSSAGKTPPTPSPKSSKKSAPKNVKTNTSSNASKSSPIPKPQQKPQEDEQTAQRIYTILAEYAEQLRNSPDLNNKPAPRRRSNPPTNPSQSSKRKKSGGKSSKPSGGQQSSEMSPSADDLGRTMGSEDSSSGIALIQDSPAGFSGQDEQSTASNIDSQSETRNNLTTSDSNDGVEVNVKRRNLIFTEPGSGQQRTVIVQEAMPTGTVNVSEALASVTGKVSGTAVLVPSGNYILPMNLVKSTQQFTIVSRGSKLLAAVPASLTTGGNSGVSNALVLQSFLNQAGKIISQQPGQVKQVKLPNLQTITSNSTAASTTTLNTTSVVVPHQTSNTTQQFTNNDSTLDNKSDSITDVIIKSEPGTPVINDATTQNTILVNKAPTIGLLQRSLSDITDTQQFCGVITSNSGLTLQGARLFNSTIGKLSTSSGSKTESVVCLASNVGESDKKPLIEQLQTENNKLGSMHSATIALTFAAPSDVTALNNSNTQNKSIQQQVAQIVQHKTRETNNIAELINKSKVISPKAVKRKLEDQILSSEKVSKSLITSIVSPSTVTSIQNHLKAEPISVVTSKQMSSIDSPSQYLINADGTSGSLDLQESTLRQSGDNEVNCKVGNGVLCGNARLQEAWEPDDRKSSPDTPWRYVPSQSNQLTIEPLKVYSRDGDSSENVQTVLQIINKGTSQSMDMNSGQLYSSNTTKKYFINHLEPFQQFTTSNKSNIVVASKNSNNNPRLERELAQQRIERNRAAMERELRLQKSLSEECEDLGVDEPSTSDLFPEADLLFDTNHSPSFDHLSQDASCSQPLGMKMYNASSYFRPLDSSSGSRETSPAPSIEIKSTERRKSISQRNRSSKDSDRLSSKRSKRDRQDENEMHNPSKHLRLSPESQDEGSNSTSDLSRLSPPHLPLMDIDSKDTMCLKKMISCNGSKEGSPTSVSSIPSNIKLDIDLDSESLPLGSNVNNTIGSSGDDSMTLMGSNTADVTIPSPLSPIAGPLLSTHKYTYTNKKRATSKVSRPEYLSWESPISERTRSSSDEEDSSISESISSQTDDLITNGLDDSLQLSSIKSTSSNFNSSTITTHSSTTGVNDRCTYLKKKDNSKVHVNARVVLNRAESKSIIAKRAKGDTINNEMGIMSQDKTSEPSDDETCHTLIEPDCRARRSSLRGHVKKGCTCCNGSPERPKKKQTGASNTVNTGNSGVTSASTGATGGGGGGGKIIEHKLKKKLVKSLGKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HIV1</accession>
    <name>A0A8J2HIV1_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to GG21441: Serine/threonine-protein kinase GG21441 (Drosophila erecta)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS8630</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5097283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HIV1"/>
    <dbReference type="OrthoDB" id="1738954at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005815">
        <property type="term" value="C:microtubule organizing center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.230">
        <property type="entry name" value="Doublecortin domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003533">
        <property type="entry name" value="Doublecortin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036572">
        <property type="entry name" value="Doublecortin_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23004">
        <property type="entry name" value="DOUBLECORTIN DOMAIN CONTAINING 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23004:SF23">
        <property type="entry name" value="DOUBLECORTIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03607">
        <property type="entry name" value="DCX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00537">
        <property type="entry name" value="DCX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89837">
        <property type="entry name" value="Doublecortin (DC)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50309">
        <property type="entry name" value="DC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Doublecortin" evidence="2">
        <location>
            <begin position="61"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="Doublecortin" evidence="2">
        <location>
            <begin position="181"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="283"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="508"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="551"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="608"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="800"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="510"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="560"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="571"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="611"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="823"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="842"/>
            <end position="872"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5097283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="872" mass="96638" checksum="637121E591DC744D" modified="2022-05-25" version="1">MMEKALSRGTSLSGESNLSTQELSPRIMGSLEERLIIENDNFTSKNQTPPTLRTPATKKAKRVRFFRNGDKFYTGIVMAVTPERYRSFDSLTTDLTRALLSNVTLPNGVRTIYSMDGKKVQTINDLEDGKCYVVSGHGELFKKVEYSSTKVRRGSSLSGLPQSPAGTGRIVTIIPSCVRARIITLIRHGSKPRKVLRLLINKRNAASLEHVLEAITQTVKLDCGVVKRVYTLSGKLVISLEQFFEAEEVFLAYGSEKSTQEDFELDIEESKCVQSFKRGSCVSKRQSGPMPVMPRKTGKRTLTAPQVRTPSPSTLTLPQPFRMHYNSFLGGEQSTSRCIAASESPQQHRNQQCQPLRVNTSFELNSSKQWSDGDGSITDICQSPVSRHQLWSEDQPKSNQLCDETDKFNGNSFAINNEEPISLSAECLQEISVLTSSMRDLMHNIDDDIVGQKTSKSVTSSLNSILENVNCNKNNNGRYLSPVYNNLHSTNKRNGNSLSDIHSKANTDKISATTSSSSSSTITNDYHRLQPVADKRCNNLSSKKSKNSIYSVSNGAAAGNKRDNDNDKYSSVENFSQSTDGLSVSSDNNIETSDSFVNIQFAKFNKTIGGSSSQSTQSSESLDNIPINRGTKLNSTVIGKKVTEDISRQVLKRNPKYNLRSTANRNSKLIEPASSSVNSRIKNSLIPLRANDQLVADNKPDTSVKSLGSDQVKMREKKAPVVKRDSNKKRFSCFSNYSGKKSQDCEDKLNSARKCSSTDELREDKQVISKINVKANRYSLYYTPQLPRKSYELEANCGKSAGKSCKNSVTLGGASRPTSWKIPESRTDETSDKRNNRKSLVDTYSYSNVKRGNKTARQSVVNLPSSNDGKIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HJ76</accession>
    <name>A0A8J2HJ76_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">PRA1 family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HICCMSTLAB_LOCUS9950</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Membrane</location>
            <topology evidence="1 5">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the PRA1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5100877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HJ76"/>
    <dbReference type="OrthoDB" id="18213at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004895">
        <property type="entry name" value="Prenylated_rab_accept_PRA1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12859:SF0">
        <property type="entry name" value="PRA1 FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12859">
        <property type="entry name" value="PRA1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03208">
        <property type="entry name" value="PRA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="48"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="75"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="105"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="128"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAG5100877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="207" mass="23158" checksum="1ED27C5E3CC56A79" modified="2022-05-25" version="1">MDKTKLGNTGMELPPLRSLDDFLLESARFQIPNLKDLDKWGNRVVNNLLYYQTNYFFMSVVIFLIVGIIHPGKMLLGMVSMTVVLALFGYVSSEGRAIHHFKKQNPLAGVIIVAAGGCFLAYTLGSLLVFLIGILLPFSATFVHASLRLRSIKNKVVNKIEGIGLKRTPMGLFLEQLDETLTQWLIKLESCGFDIYSDDDNLNKKNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HJB7</accession>
    <name>A0A8J2HJB7_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similar to IMP4: U3 small nucleolar ribonucleoprotein protein IMP4 (Bos taurus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS11485</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5103389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HJB7"/>
    <dbReference type="OrthoDB" id="10253204at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034457">
        <property type="term" value="C:Mpp10 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042134">
        <property type="term" value="F:rRNA primary transcript binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10480:FF:000001">
        <property type="entry name" value="IMP4, U3 small nucleolar ribonucleoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10480">
        <property type="entry name" value="Probable brix-domain ribosomal biogenesis protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007109">
        <property type="entry name" value="Brix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044281">
        <property type="entry name" value="IMP4/RPF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22734">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RIBONUCLEOPROTEIN PROTEIN IMP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22734:SF2">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RIBONUCLEOPROTEIN PROTEIN IMP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04427">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00879">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50833">
        <property type="entry name" value="BRIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0687">Ribonucleoprotein</keyword>
    <feature type="domain" description="Brix" evidence="1">
        <location>
            <begin position="94"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5103389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="311" mass="36315" checksum="4818D63B12EBB747" modified="2022-05-25" version="1">MLRRQARLRREYLYRKSKEDKIKTIQEKKDKLKKSLENNVPIHPDLRKDALYLQRKLDWEDAGPERAVAMGTEMGGTTGTHEDDEYRWAGVEDPKIMLTTSRDPSARLKKFVKEVRLIFPTAQRLNRGNAEMKTLIEVCRANQVTDFIVIHEHRGVPDHLVICHLPYGPTAYFTLSNVVMRHDIPEIGTMSEQYPHLIFHNFKSTLGIRTMNILKHLFPVPKEDSKRVMAFANHDDFISFRHYTYKKSGGQDVEMTEVGPRFTLKLYKIKLGTMDSIEAADTEWNLGTFMNTTHKRRFLSNDDGWDQEDDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HJW1</accession>
    <name>A0A8J2HJW1_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">WD repeat domain phosphoinositide-interacting protein 3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">WD repeat-containing protein 45B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HICCMSTLAB_LOCUS9869</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Lysosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the WD repeat PROPPIN family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5100796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HJW1"/>
    <dbReference type="OrthoDB" id="1667587at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000083">
        <property type="entry name" value="WD repeat domain phosphoinositide-interacting protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048720">
        <property type="entry name" value="PROPPIN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11227">
        <property type="entry name" value="WD-REPEAT PROTEIN INTERACTING WITH PHOSPHOINOSIDES WIPI -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21032">
        <property type="entry name" value="PROPPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0072">Autophagy</keyword>
    <keyword evidence="5" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="6" id="KW-0458">Lysosome</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0853">WD repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00040656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00041573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAG5100796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="344" mass="38379" checksum="271E710A2202224B" modified="2022-05-25" version="1">MNLSTGNTYSNGLVYAGFNQDQGCFACGMENGYRVYNCDPLKEKERHDFEGDGGLGYVEMLFRCNYLALIGGGDKPVYPTNRVVIWDDIKKLPAITLEFNAPVKGVKLRRDRIVAILEGVIKVFTFTQNPQQLHVFETNPNPRGLCVLCPNSDNSLLAFPGRKNGHIQIIDLANTEKQPLNIEAHETPLSCIALNLQGTRLATASEKGTLIRVFDTQTGTMINELRRGANHANIYCINFNHDSTWLCVASDHGTVHVFAVEDQKLNRQSSLASATFLPKYFSSSWSFCKFQVPGGPQCLCAFGTNNSIIVICADGSYYKFVFNNKGECTRDFYAQFLEMTDDKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HK16</accession>
    <name>A0A8J2HK16_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Oligomycin sensitivity conferral protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HICCMSTLAB_LOCUS7065</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATPase delta chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5093739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HK16"/>
    <dbReference type="OrthoDB" id="1262810at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.520.20">
        <property type="entry name" value="N-terminal domain of the delta subunit of the F1F0-ATP synthase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01416">
        <property type="entry name" value="ATP_synth_delta_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026015">
        <property type="entry name" value="ATP_synth_OSCP/delta_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000711">
        <property type="entry name" value="ATPase_OSCP/dsu"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01145">
        <property type="entry name" value="ATP_synt_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11910">
        <property type="entry name" value="ATP SYNTHASE DELTA CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00213">
        <property type="entry name" value="OSCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47928">
        <property type="entry name" value="N-terminal domain of the delta subunit of the F1F0-ATP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="4" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00033369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAG5093739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="186" mass="19898" checksum="23C90969B95F1F6B" modified="2022-05-25" version="1">MSSSRLNMIVRSFSSSPVTQQLVKPPLQVFGVEGRYATALFSAASKQSSLDAVEKDLLKFQADAFKAISTKINLNPATANLLALLAENGRLGLLNQVINAFKLIMAANRGEVVCEVTTSKPLDAESKTKLESALKLFLTKGQTLLLTTKVDPSIIGGMVVSIGDKYVDMSIASKVKKYSDIISTAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HK45</accession>
    <name>A0A8J2HK45_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS9389</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5100110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HK45"/>
    <dbReference type="OrthoDB" id="10411663at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5100110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="439" mass="48779" checksum="E19A4F7186E69651" modified="2022-05-25" version="1">MGLFVYVHGTYRPIMGLKIFGKVSSKLKYMISFETVISFLSRHLNPYQTYPPETCLFPVSSLLSSSHLSSSVILNLFERKSDSPKSYLSEFGTDNGIEIGFNACGIKFCGLLLPIVGFAHLFFGVDFKLCSRRELQETLIDLLTKLMVMIIKTLTDVGSFIFTNVICTTLADYQEKDHSSKDKRASNNGSHAENHTIANKNGLLSVAKNNFSSNNSDVFNDTKVTKDKDGAHISKIAGDTFANESVSNQTKLVKNKDGSTIIEESVKTVDTNHTDVTKTEKVLNADGGITDKETKINKSKNRTTDDKTHLIQNKDGTATVESVITITDDNTTTTNQTGVTNNKYGTSIMDPHITVEHDKETTVYKTDVTKNKDGTTTVDEFVIITTKYSKIIHHIVKRKYANGYIKIITDTVTRNCITYNCNQKFSGPLRDACNKHVPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HKU3</accession>
    <name>A0A8J2HKU3_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Similar to Mrc2: C-type mannose receptor 2 (Mus musculus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HICCMSTLAB_LOCUS10577</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5101675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HKU3"/>
    <dbReference type="OrthoDB" id="6356110at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00033">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00037">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.70.10">
        <property type="entry name" value="Complement Module, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050111">
        <property type="entry name" value="C-type_lectin/snaclec_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035976">
        <property type="entry name" value="Sushi/SCR/CCP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000436">
        <property type="entry name" value="Sushi_SCR_CCP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22803">
        <property type="entry name" value="MANNOSE, PHOSPHOLIPASE, LECTIN RECEPTOR RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00084">
        <property type="entry name" value="Sushi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00032">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57535">
        <property type="entry name" value="Complement control module/SCR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50923">
        <property type="entry name" value="SUSHI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0768">Sushi</keyword>
    <feature type="domain" description="C-type lectin" evidence="5">
        <location>
            <begin position="22"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="5">
        <location>
            <begin position="163"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="5">
        <location>
            <begin position="300"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="6">
        <location>
            <begin position="433"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="707"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="707"/>
            <end position="751"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAG5101675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="758" mass="86901" checksum="64F2111BEF202BA5" modified="2022-05-25" version="1">MTVSKEERQPVVEYYRENSVQYLLFSQRVTWDEARMICKSYFSRLAILDTMEKAVAVGRLLADSNIEMEDTWLGAKRIDFVWYWMDRDAGPWKNVLPTESNVENFPPWSREPVRPTKECLAIDRQHHQHPNFIDLDCRLQRPFICQKKDSEINSPIPSKWVQINRNTFTLYHGKVTWQEAAIYCRTQGSRLAVIKNLIVTHILSNSMTKTRPDFESVWIGAYFNDGNWIWLSTGSILNSLTDESGYPPWRYGRPEANSGCLLLDRHMEKNSTFLEVSCDHKRNTDDEENDWWDDPIKFSYDNNTYVIYPLEKTWNESASHCISSGSVLAQVNNINTVNMIIEAMGDHPRELSHVWLGGYYNPKTDEWVWTSSHKKIPRDKDESGFPPWTNIEGDDGIVSQPSSTCLNLDRADHVKSHFYGLDCDSKQPFVCKTTCDIPPIISNGTWNCINIINGRECSLRCTKNLMINGINTITCTLNNGWIAGENLMEFPICSNTSDYTRRIIHSLGEDIRRSSAYYLLMDHSAQNIKSSALKFAQNILKAFPASNQLRTGMTSYITDPPVFIPFNQTNNCLLVSALKYLQNSTVKNITVVANITRINKDISTYNGRKITIIAVIDFDRGSHYIDILMHFKAIGHQIAIIGLREHLKILLPLATIGFDHRANLFLFQDNEFEMIVNELQKQKKKLKCADYPVNSIANNFVVVEKTNSANQPPKNPESTLISTSPSQVKEQVSATEENSQTSITEETTTVENDYEQER</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HLS4</accession>
    <name>A0A8J2HLS4_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">H/ACA ribonucleoprotein complex non-core subunit NAF1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HICCMSTLAB_LOCUS10517</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NAF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5101615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HLS4"/>
    <dbReference type="OrthoDB" id="21550at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005732">
        <property type="term" value="C:sno(s)RNA-containing ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000493">
        <property type="term" value="P:box H/ACA snoRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001522">
        <property type="term" value="P:pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.230">
        <property type="entry name" value="Probable tRNA pseudouridine synthase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038664">
        <property type="entry name" value="Gar1/Naf1_Cbf5-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007504">
        <property type="entry name" value="H/ACA_rnp_Gar1/Naf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040309">
        <property type="entry name" value="Naf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31633">
        <property type="entry name" value="H/ACA RIBONUCLEOPROTEIN COMPLEX NON-CORE SUBUNIT NAF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31633:SF1">
        <property type="entry name" value="H_ACA RIBONUCLEOPROTEIN COMPLEX NON-CORE SUBUNIT NAF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04410">
        <property type="entry name" value="Gar1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="95"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="293"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="413"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="12"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="35"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="45"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="97"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="113"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="123"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="297"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="338"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="436"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="460"/>
            <end position="469"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAG5101615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="469" mass="52833" checksum="C2A6FAF6BF1F6D55" modified="2022-05-25" version="1">MSKVQEDAEAVNINSKSNMSTLERTNALSVIAASYDDDVDENEDQSTPNSEEQNKLISSEMVICDQEKTSENVEPVVLKEITVVDPEPELSIVKEQITLSDSQRQNYRTQDSDSSDSEDDSSSSDSSSSSSSSEAESENEDSDNEKVQSNKFRFADISSRSSLRPSGRSNILLVGWVVEQMVVVTPKATKPTLNFDTILFVDKGKRVLGRVFDVFGPVTEPHYCVRFNNAQHIEESNIKVGMTVYYCPNTPYTTLVFMTDLLKMKASDDVGEDEHPEFSDDEEEKAYFASLKQKQRNNNNKNNNNSNSNGNNNKSNDTNRSTPSSKRQKKNDGWKSQHPWNNSRRTDQRGQNYHWYQQAQNQSHFYSQPQPQQNMWAPYPSNAPSNPSYHYGYQNWYGYPQSEYSAHPSYQQNVDLTRQPGPSFAWQANSTFTPTPTNPTWPILPPPPPPPPPPPPPSQPSQSPTSPGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HMG5</accession>
    <name>A0A8J2HMG5_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Similar to Cuticle protein 6 (Blaberus craniifer)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HICCMSTLAB_LOCUS11652</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5103723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HMG5"/>
    <dbReference type="OrthoDB" id="6515429at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062129">
        <property type="term" value="C:chitin-based extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008010">
        <property type="term" value="F:structural constituent of chitin-based larval cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050468">
        <property type="entry name" value="Cuticle_Struct_Prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000618">
        <property type="entry name" value="Insect_cuticle"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10380">
        <property type="entry name" value="CUTICLE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10380:SF196">
        <property type="entry name" value="CUTICULAR PROTEIN 72EA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00379">
        <property type="entry name" value="Chitin_bind_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51155">
        <property type="entry name" value="CHIT_BIND_RR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0193">Cuticle</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035236098" evidence="3">
        <location>
            <begin position="21"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="28"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="243"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="35"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="254"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG5103723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="363" mass="39534" checksum="CE9B4197D5341114" modified="2022-05-25" version="1">MIRKFSLLILLVGCLSVTSAQSLYLQEPNHHQRSHSNNINSNNNNRDPLVSSTPESPKEPEGVSVPASEDSTRAFTASVHGHQVNNVPTYPGAPIGPDGRVIDTQDVTVAKAKHAAAYINQKVNLAREAARSNAGGLAKSPEVLLEYQDSLGQYSFGYSAPGSARSEVGAADGSTRGAFSYVDGSGVIQTAKYTADGENGFRIEASNLPVAPRPVEETPEVQAARIEHFRAYEEAKKNLIAAGSLMPDQSTGENQDKIIEKENKKDEIKEEKKSEKEEKKESLMMAKLKNRIELIGSGSGAGNFYGSAPSADQGNAKGNEKLQLKTSDASHVQFYRTPLVRYSPIGYPVYYNHLQYVPSYYYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HN63</accession>
    <name>A0A8J2HN63_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Olfactory receptor 73</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HICCMSTLAB_LOCUS9382</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5100096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HN63"/>
    <dbReference type="OrthoDB" id="6604226at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005549">
        <property type="term" value="F:odorant binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004984">
        <property type="term" value="F:olfactory receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004117">
        <property type="entry name" value="7tm6_olfct_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21137">
        <property type="entry name" value="ODORANT RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21137:SF35">
        <property type="entry name" value="ODORANT RECEPTOR 19A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02949">
        <property type="entry name" value="7tm_6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0552">Olfaction</keyword>
    <keyword evidence="8 11" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="9" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="41"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="99"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="144"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="268"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAG5100096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="365" mass="42649" checksum="CFEA9D7459BDEB21" modified="2022-05-25" version="1" fragment="single">MKILNTTIRVVNWIIVITTLATIAADVYVNIKDIEAVTNNMGYLFPMLGILIKTFAVVKNQLSIRQLIEDIHINIDRLRYSSDLGVLTKIRTTLFYQNFDYFAIATILSGTVIALIAMSAETETKLALRGIFPYNITVSPTYEIAFFMQFWTVFMCCLWILILESSIIELIRWTNVQLVVLQANFEHCQDWQMPRASFNMSKKNYNTIRNYKYFKVSDEQTLIQSYIPFNDEEANVQKDSFALRFKTCLKHYRRIIDHVKKYNEFFSILQFFSVFITCSFVCFCLFQIVLAEMLHISQYNCGWESQLNRNDRHFVVNALIQSKQPLQITAGKFFVLSLETYLKVIKNSYSYFAILNTVHGNNDNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HNN3</accession>
    <name>A0A8J2HNN3_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Similar to YAF2: YY1-associated factor 2 (Homo sapiens)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HICCMSTLAB_LOCUS11762</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5103943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HNN3"/>
    <dbReference type="OrthoDB" id="10063208at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1060.10:FF:000009">
        <property type="entry name" value="YY1 associated factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1060.10">
        <property type="entry name" value="Zinc finger, RanBP2-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039958">
        <property type="entry name" value="RYBP/YAF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033774">
        <property type="entry name" value="YAF2_RYBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001876">
        <property type="entry name" value="Znf_RanBP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036443">
        <property type="entry name" value="Znf_RanBP2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12920:SF4">
        <property type="entry name" value="GEO03726P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12920">
        <property type="entry name" value="RYBP AND YAF2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17219">
        <property type="entry name" value="YAF2_RYBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00641">
        <property type="entry name" value="Zn_ribbon_RanBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00547">
        <property type="entry name" value="ZnF_RBZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90209">
        <property type="entry name" value="Ran binding protein zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01358">
        <property type="entry name" value="ZF_RANBP2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50199">
        <property type="entry name" value="ZF_RANBP2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RanBP2-type" evidence="10">
        <location>
            <begin position="15"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="60"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="95"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="117"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="141"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAG5103943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="172" mass="18984" checksum="B43CC2C1C9ED0D94" modified="2022-05-25" version="1">MNHSGSGKRQAKVLEDNYWDCSVCTYRNTAEAFKCLMCDVRKGTSTRKPRINPQLAAQQAAQQQYVPLLKPGKKEGGSGSSTTSSSKDNKERKLDKPRRKNRHPPRLKNVDRSTAQTNEVTVNNVTVIITEYKPKVKKNSDQSGLSSSASSENGSQHDSNQDSRSLDIGTDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HNY7</accession>
    <name>A0A8J2HNY7_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS13891</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5109255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HNY7"/>
    <dbReference type="OrthoDB" id="7693421at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5109255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="111" mass="13002" checksum="EF275EF685993FBE" modified="2022-05-25" version="1">MANIDYKLQCLINNGIKFIFNLERDEHITPQRRSLQWLTVKSKRCYFLACFLYKLFSSGEPSFLRSMFVKESPDIRCSERLAAKHNNVTFKIPNFSTASYEHSFLISSIPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HP26</accession>
    <name>A0A8J2HP26_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Similar to Tret1: Facilitated trehalose transporter Tret1 (Bombyx mori)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HICCMSTLAB_LOCUS11478</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5103375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HP26"/>
    <dbReference type="OrthoDB" id="6133115at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050549">
        <property type="entry name" value="MFS_Trehalose_Transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48021">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48021:SF39">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="40"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="83"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="112"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="135"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="169"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="193"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="281"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="321"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="349"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="377"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="428"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="458"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="483"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="40"/>
            <end position="510"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAG5103375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="558" mass="62168" checksum="D8784D07B1527BCB" modified="2022-05-25" version="1">MTADIPEVDIRHGKINGSVEANGTSEKLEISKLRQALPQVFAVSAKNLLLLTFGTTLGFPTILIPSLQKEDADITVTREEITWISSINLFMVPLGCLMSGPISHRLGRKKTMLFINIPFISAWILFYYANSTPLLFLALALTGITGGLCEAPVLTYVAEITQPHLRGMLSATSSMAVIIGVFMQLLVGSLTDWRTVALINLIFPTICFLALCLMPESPYWLAGKNRLKEAEEALCWLRGWVSPSYITGELKTVYEVSQRIVAGGMDDKKEYWWKIFSKRTFIYPYILISLGFFISSFGGSATLQTFAVTIFASLDAPLEKYTATVFLGLAELIGTAVCVIIIHFTGKRVITFISIGGAGFCFMTCAIYDYLNRSAYIDGQMFTWIPTTLLISSAFFSHMGIRLLPWVLCGEVFPAKLSNFTLVLWGDFQALIHFCIFLVKLSVNIFKKLMDGRSTATGAAACTGYIFASIINKTFLYMVDLMYLWGTFFFYASVNVIGFIVMYYLLPETEGRTLKEIEDHYAGIESLNNKPSKDKSQLKEKWAVSNPAMVVDDLESKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HQF8</accession>
    <name>A0A8J2HQF8_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS11260</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5102940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HQF8"/>
    <dbReference type="OrthoDB" id="10068710at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33480">
        <property type="entry name" value="SET DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33480:SF1">
        <property type="entry name" value="TYR RECOMBINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5102940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="264" mass="30350" checksum="1643661B4EC535B9" modified="2022-05-25" version="1">MSLNFVWVYMKSLSSSTLNNTKDDSSYVLPPDTSLDQSSELCTNIEDETTENLEDTEDNESVIEELIKKSNPPKLDDLEVPRAGEETKKSFCCFCFHSFVVISRHYEAIHSDEKEVQHFLSLKKRSTERIAAIEKLRLKGTQLFNLNNDFNHGRLLVTRQPQKTSLANVHDFKPCHKCGRWLQYINRHKCPYGKESNGDRSDLIKSKILMGQICNNATSLTRKILAINNDDSISEAVRQDPLLITFVNELSQKYTNPHQHSMIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HQP4</accession>
    <name>A0A8J2HQP4_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Synaptosomal-associated protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HICCMSTLAB_LOCUS12546</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Synapse</location>
            <location evidence="6">Synaptosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the SNAP-25 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5107021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HQP4"/>
    <dbReference type="OrthoDB" id="19261at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098793">
        <property type="term" value="C:presynapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019905">
        <property type="term" value="F:syntaxin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031629">
        <property type="term" value="P:synaptic vesicle fusion to presynaptic active zone membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016082">
        <property type="term" value="P:synaptic vesicle priming"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15885">
        <property type="entry name" value="SNARE_SNAP25C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15889">
        <property type="entry name" value="SNARE_SNAP25N_23N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000007">
        <property type="entry name" value="Synaptosomal-associated protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000018">
        <property type="entry name" value="Synaptosomal-associated protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000928">
        <property type="entry name" value="SNAP-25_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19305">
        <property type="entry name" value="SYNAPTOSOMAL ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19305:SF14">
        <property type="entry name" value="SYNAPTOSOMAL-ASSOCIATED PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00835">
        <property type="entry name" value="SNAP-25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0770">Synapse</keyword>
    <keyword evidence="2" id="KW-0771">Synaptosome</keyword>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="9">
        <location>
            <begin position="30"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="9">
        <location>
            <begin position="152"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="61"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00034102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAG5107021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="216" mass="23921" checksum="51F12DFB9C6D0B66" modified="2022-05-25" version="1">MPAPTADAAGPAEGAGPPRTELQELQLKADQTTDESLESTRRMLALCEESHEVGMKSLVMLDEQGEQLDRIEEGMDQINADMREAEKNLTGMEKCCGICVLPCNKGASFKEDEGTWKGNDDGKVVNNQPQRVMDDRNGLGPQGGYIAKINNDARENEMEDNMGQVSTMIGNLRNMAIDMGSELENQNRQIDRINRKGESNETRIQVANERAHQLLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HQS3</accession>
    <name>A0A8J2HQS3_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HECT-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="3">2.3.2.26</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HICCMSTLAB_LOCUS13486</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.26"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.26" evidence="3"/>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5108850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HQS3"/>
    <dbReference type="OrthoDB" id="6057829at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043066">
        <property type="term" value="P:negative regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009966">
        <property type="term" value="P:regulation of signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00078">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2160.10:FF:000008">
        <property type="entry name" value="Apoptosis-resistant E3 ubiquitin protein ligase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2410.10:FF:000013">
        <property type="entry name" value="Apoptosis-resistant E3 ubiquitin protein ligase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000975">
        <property type="entry name" value="Uncharacterized protein, isoform D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2160.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2410.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050409">
        <property type="entry name" value="E3_ubiq-protein_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017868">
        <property type="entry name" value="Filamin/ABP280_repeat-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000569">
        <property type="entry name" value="HECT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035983">
        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11254:SF340">
        <property type="entry name" value="APOPTOSIS-RESISTANT E3 UBIQUITIN PROTEIN LIGASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11254">
        <property type="entry name" value="HECT DOMAIN UBIQUITIN-PROTEIN LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00630">
        <property type="entry name" value="Filamin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00632">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00119">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56204">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50194">
        <property type="entry name" value="FILAMIN_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50237">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 7" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="repeat" description="Filamin" evidence="6">
        <location>
            <begin position="201"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="domain" description="HECT" evidence="8">
        <location>
            <begin position="473"/>
            <end position="813"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAG5108850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="813" mass="91698" checksum="BE52497DE18CD588" modified="2022-05-25" version="1">MPDKNPGNRNGQRNKKFFANEISSIGMSLRPSGSSSSGISSLASCGEVGALPELPAQDEERLQRAARLLQQRLVLRQWLSDHGLSSYYQKLMQMDVLSLEDVYWVEDNEARSTLGKDLPRWIQARQTLPTSKDDLESLKSDLWSSVVKNSQHQDAWTWGGMLVVSVSVAGLVTLAAMTQPALAPEAKHSLLQYVTGKYLLPSNCRVHFEWEEPQLVGETMTFTVKFYQRNGQPYPICDKDNLIIDVSEGTRRVATLIDLGGTDPLAANTAVVKFTVRHAGQYRIAVLIGSCHVHGSPFLKNFLPGPPDPNKTVFVRQSSTVVCTAGIAHSMTIEPRDEYDNLCIGCTEEGQAVVCNIQLEYDQPNQRIRLKVGFPKGGCYHATVSLAGLQLHNGDFDIIVLDSSVARMVHNNVASKDPDICYAAKLLGMQDKQDFFYHEVRKHHQKHYHEKLTIKVQRDKLLESSMKATKSFSISDWCRNFEITFQGEQGVDWGGVRREWFELICAALFDPGNGLFASFGESQQALVHPNNKRSQNLKWKHYEFAGRIVGKCLYESALGGSYRQLVRARFTRSFLAQIIGLRVHYKYFEQDDPDLYLSKVKYILENDVEEMELFFVEEEYDKDGQLTKVAELIPGGSKLRVTNDTKLRYLDALAQHRLASSIRNEVDSFLRGLNELIPDNLLGIFDENELELLLCGTGEYSVADLRAHHVVNGSSPEFLRVLDWFWTAISNFTQEEMARLLQFTTGCSQLPPGGFQQLSPRFQITAAPTFANLPTAHTWYFNQLCLPDYECYDHFERALLLAISEGTEGFGMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HQT4</accession>
    <name>A0A8J2HQT4_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 15">Cytochrome c oxidase subunit 5A, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14 15">Cytochrome c oxidase polypeptide Va</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">HICCMSTLAB_LOCUS12622</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="15">Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 15">Energy metabolism; oxidative phosphorylation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="15">Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of a catalytic core of 3 subunits and several supernumerary subunits. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 15">Mitochondrion inner membrane</location>
            <topology evidence="1 15">Peripheral membrane protein</topology>
            <orientation evidence="1 15">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the cytochrome c oxidase subunit 5A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5107184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HQT4"/>
    <dbReference type="OrthoDB" id="5778907at2759"/>
    <dbReference type="UniPathway" id="UPA00705"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045277">
        <property type="term" value="C:respiratory chain complex IV"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006123">
        <property type="term" value="P:mitochondrial electron transport, cytochrome c to oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00923">
        <property type="entry name" value="Cyt_c_Oxidase_Va"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.40:FF:000002">
        <property type="entry name" value="cytochrome c oxidase subunit 5A, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.40">
        <property type="entry name" value="Cytochrome c oxidase, subunit Va/VI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003204">
        <property type="entry name" value="Cyt_c_oxidase_su5A/6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036545">
        <property type="entry name" value="Cyt_c_oxidase_su5A/6_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14200">
        <property type="entry name" value="CYTOCHROME C OXIDASE POLYPEPTIDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14200:SF11">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT 5A, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02284">
        <property type="entry name" value="COX5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48479">
        <property type="entry name" value="Cytochrome c oxidase subunit E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 15" id="KW-0349">Heme</keyword>
    <keyword evidence="11 15" id="KW-0408">Iron</keyword>
    <keyword evidence="13 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12 15" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8 15" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 15" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="9" id="KW-0832">Ubl conjugation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00031049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU368103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CAG5107184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="154" mass="17299" checksum="FB1794CAC0143263" modified="2022-05-25" version="1">MLRFVAGRIGSAVRGVVAVPRTSAAIGVTSTRNSSHGPEETDEEFDTRMENYFNRKDIDSWEIRTAMNDLAGMDLVPEPRIVSAALKACRRLNDYALAVRFLEVVRYKGGDQAHVIWPYIVQEIRPTLDELGILTPEEMGYDKPELALISPYEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HRE9</accession>
    <name>A0A8J2HRE9_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein CASC3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">HICCMSTLAB_LOCUS13548</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell projection</location>
            <location evidence="2">Dendrite</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Stress granule</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
            <location evidence="4">Perinuclear region</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Nucleus speckle</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the CASC3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5108912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HRE9"/>
    <dbReference type="OrthoDB" id="657902at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010494">
        <property type="term" value="C:cytoplasmic stress granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030425">
        <property type="term" value="C:dendrite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035145">
        <property type="term" value="C:exon-exon junction complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000184">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018545">
        <property type="entry name" value="Btz_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028544">
        <property type="entry name" value="CASC3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13434">
        <property type="entry name" value="PROTEIN CASC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13434:SF0">
        <property type="entry name" value="PROTEIN CASC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09405">
        <property type="entry name" value="Btz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01044">
        <property type="entry name" value="Btz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="17" id="KW-0966">Cell projection</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="15" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="11" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="14" id="KW-0866">Nonsense-mediated mRNA decay</keyword>
    <keyword evidence="16" id="KW-0539">Nucleus</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="10" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="12" id="KW-0810">Translation regulation</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Btz" evidence="19">
        <location>
            <begin position="62"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="173"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="352"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="405"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="613"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="73"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="107"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="127"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="417"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="439"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="501"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="541"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="18">
        <location>
            <begin position="625"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="647"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="674"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="704"/>
            <end position="720"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00009548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00019964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="SMART" id="SM01044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="CAG5108912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="922" mass="103687" checksum="7B3DC1BA1A01EE17" modified="2022-05-25" version="1">MIKSDTNMSDTRRRRHKSERSHASDDLSESFDELAITKDTESNDQSDITVHHDSEYDTAGSDGESDGGSQDGVQRERGDGQEEDKPQKKLDDDEDRRNPQYIPKRGTFYEHDDRTTEEAAEDTVEQPVERESKDKKVWKDKEDRWDHDRYNDQEQAPKSHDELIAVYGYDIRNEEGPPRARRRRRYGRGPNKYTRNWEDEDAYGKTPINTSTKQNRRLNKTGEEFPALGGSVKDDKQDAVEEPVISSAWYSNKNKYSKQQNAFPPLQSQLDNQRTRLLATNDIHTNENKAPNEPTNPAWKKDAKYSHQSLIANINAGDDIEKTTTANVKPAYVNKRQVQESVSLAASRVRGRGFKPTANNNLITNRAPDTKPKGRGSGLITGGDRRNIMSRDDDQFVNEVKHINVNDGSTYHHGRQQKTFYGQGSNQQRPSVGSPRMQPPTQQHQQQQQQQQQQQQQQQQQPQAHSRSPSEMGGNRPKRYSSLRQRPAISDGPGQQNYPTQHNQHGQHSQHGPHGQHNQLGQHGFYSPQGGNSHGVIESQGYPQNHFDQSPQVPQTANTLAPQSVMPLPSAGQPGSFAPPPFLVPTPQFIAPQTAAPNIINYVQAPNGPAFPPNFQGYQGYTPSVQPPVPQPPPELYQPQGCTYYSPAQQPQQVPQIAPLRRPKAIPILPPPDNNSVQRQQSSRGRGRNVSQASSCSGPGGQLSPGEQQQQQHQQFQQIDTQQCVSVESINNSSNDIYNNLPVEHVEQISESMIPQMPNEETNIFDESISLDNKSIVENIREDNDESVENVLIETLNENITENFIENINENLEEEKSDIKTDNIEEIISNEPTKENIDINNLNNDIKNDLMDKTNENDNDVVSITKNDCENNIDETVVVIDNNSNNSLSKTIEVDSVTINQTDINNKVENVVSTPVVEEAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HRW4</accession>
    <name>A0A8J2HRW4_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Similar to OSGIN1: Oxidative stress-induced growth inhibitor 1 (Homo sapiens)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS13304</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5108572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HRW4"/>
    <dbReference type="OrthoDB" id="412005at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029731">
        <property type="entry name" value="OSGIN1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15192:SF8">
        <property type="entry name" value="FAD_NAD(P)-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15192">
        <property type="entry name" value="PROTEIN CBG05349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5108572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="582" mass="64788" checksum="77ED5BE0556C5814" modified="2022-05-25" version="1">MQQLSNALEETVYYKDVVIVGNGPGAMFLSFMLNGNWPYYTGGSHPGDEMLTARLHYILDKANQVMTHNVEIKKEDETRENLLMYKNEDKKTGKSNSGIQTQIEIENTERKSLLECTREELEILATGVEGRGTCRPLALLMDQLQHPCVDSGLNLPGLIAWKSAEHCPRQKIVNHVVLGKGPPGGAWQFMDPNVLTISLSRWMSLPGLDFQKWERLVGAEQLHKISISLQDARLSAEPNFDTLDAMKRIPVGIVAAYYKDYVKKQGLAKYFKTGRTITSVRPILDTTNTEDSYGWVVKGYDNLSGRKFRYKCKKVVLASGSTNTFNRLGLAGEETQSSWVTHDLNDLETRLDRLAGKCKKCGARENQDLSKIDPILVVGAGLSAADAIITARCRGIPVIHAFRESSDASSDESESGVKLSANVYERLQTLPISMYPEYHKIYEMMADGRNHRLYKSLAGYKLVDLGVKSNDSNKTKERRVTLRSPSGQLFTFRVSIVAILIGSKPDLSYLGDYANKLGKVEDKPISGRSNPILVDDFTYQVIKSPREGLYAIGSLVGDNFVRFILGGAFGVASHILRTIDTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HRW5</accession>
    <name>A0A8J2HRW5_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS13837</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5109201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HRW5"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5109201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="72" mass="7891" checksum="F22C156B23C35192" modified="2022-05-25" version="1">MQLCVRFITTVLSSRTLKLLLRERDDLKVRSGLTGNVPVLLTTAIFGDEGDIDDIGANDCVGDGDDDDEDFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HTV6</accession>
    <name>A0A8J2HTV6_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">mRNA guanylyltransferase</fullName>
            <ecNumber evidence="2">2.7.7.50</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">HICCMSTLAB_LOCUS13391</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>a 5'-end diphospho-ribonucleoside in mRNA + GTP + H(+) = a 5'-end (5'-triphosphoguanosine)-ribonucleoside in mRNA + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:67012"/>
            <dbReference type="Rhea" id="RHEA-COMP:17165"/>
            <dbReference type="Rhea" id="RHEA-COMP:17166"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:167616"/>
            <dbReference type="ChEBI" id="CHEBI:167617"/>
            <dbReference type="EC" id="2.7.7.50"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:67013"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.50" evidence="2"/>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5108746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HTV6"/>
    <dbReference type="OrthoDB" id="200924at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004484">
        <property type="term" value="F:mRNA guanylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004721">
        <property type="term" value="F:phosphoprotein phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006370">
        <property type="term" value="P:7-methylguanosine mRNA capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07895">
        <property type="entry name" value="Adenylation_mRNA_capping"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17664">
        <property type="entry name" value="Mce1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000291">
        <property type="entry name" value="mRNA-capping enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.30:FF:000040">
        <property type="entry name" value="mRNA-capping enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.10:FF:000040">
        <property type="entry name" value="mRNA-capping enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.30">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000340">
        <property type="entry name" value="Dual-sp_phosphatase_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001339">
        <property type="entry name" value="mRNA_cap_enzyme_adenylation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013846">
        <property type="entry name" value="mRNA_cap_enzyme_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051029">
        <property type="entry name" value="mRNA_Capping_Enz/RNA_Phosphat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10367">
        <property type="entry name" value="MRNA-CAPPING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10367:SF17">
        <property type="entry name" value="MRNA-CAPPING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00782">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03919">
        <property type="entry name" value="mRNA_cap_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01331">
        <property type="entry name" value="mRNA_cap_enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56091">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50054">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0506">mRNA capping</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="13" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="14">
        <location>
            <begin position="43"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="15">
        <location>
            <begin position="112"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="13">
        <location>
            <begin position="721"/>
            <end position="753"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00044624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CAG5108746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="888" mass="100682" checksum="14E8C4D826AA7CA4" modified="2022-05-25" version="1">MSSVNGESSKGPIPPRWLHCPRKSVKLIHNKFLAFKTPLSTHFDDQVSEDCRFNVDMLFASVKSERLKIGLWIDLTNTNRFYEKDDVEAYGCKYFKLQCRGHGETPSRDQSKTFVEICKNFIAKHPLEIIGVHCTHGFNRTGFLIVSYLVETDQFSIDAALNIFSAMRPPGIYKDDYIKELFRRYDDVDDAPAAPPRPAWCLEYDDDDDDVDDDVYHQSASGNQSHGRRKREYVNKNPVFMAGVPGVVVVNDHAKSSGIQRRVQEICGWNSSGFPGSQPVSMDRNNINKLSEKPYRVSWKADGTRYMLLIQGGNELFFIDRDNSVFQVSGLAFPHAHDTMRNLKDTLLDGEMVIDRADGKEYPRYLAYDIIMYDGKDVSKKPFFPDRYALIEKEVMGGRYRALREGRLRREREPFSVRLKQFYDIAQTGSLLSEKFAKQLGHEPDGLIFQPAKDPYVPGTCDSVLKWKPLSLNSVDFKLKIVTDSGLGILPTKKGMLFVGGLNEPFDKIEKPSKAVRELNNKIIECKWENNKWVFMRERTDKSFPNSYKTAVSVCQNRTVQIWCTKDLASKERKSLRVNIDYDFATNVRVSPDGKAFIIHKSLSNNVEVYGLRKKPNGFFVSATLVLEFPKRHQEDIVGMEIACNGRFIMTCGKTNDLIIWDLKGEVLATVDTYLGTTHMAKISPCGRFIAASGFTPDVKVWEVGFTKSGEFKQVTTAFNLGGHSSGVYDFDFNADSSFMASVSKDGTYRLYDTKVEFEKGEDPHFVLSGTWENVTPTKMVMSPNGEVLVITHGSSLSFYSTISGKLDTTIEDIGFVSCLTFDASGEYLLVAVDRFIRIIRNIPGYRAAIESAKRKLEQRQTSATKERLEKIISNSTKFLESMGERVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HTV8</accession>
    <name>A0A8J2HTV8_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Similar to tmed1: Transmembrane emp24 domain-containing protein 1 (Xenopus tropicalis)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HICCMSTLAB_LOCUS13438</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Endomembrane system</location>
            <topology evidence="8">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 9">Membrane</location>
            <topology evidence="1 9">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the EMP24/GP25L family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5108802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HTV8"/>
    <dbReference type="OrthoDB" id="10037706at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015720">
        <property type="entry name" value="Emp24-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009038">
        <property type="entry name" value="GOLD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036598">
        <property type="entry name" value="GOLD_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22811">
        <property type="entry name" value="TRANSMEMBRANE EMP24 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01105">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01190">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101576">
        <property type="entry name" value="Supernatant protein factor (SPF), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50866">
        <property type="entry name" value="GOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0732">Signal</keyword>
    <keyword evidence="4 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035199820" evidence="11">
        <location>
            <begin position="20"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="192"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="GOLD" evidence="12">
        <location>
            <begin position="45"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00037847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAG5108802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="227" mass="25911" checksum="ADF31099B06278F0" modified="2022-05-25" version="1">MNLVSYLFIAGTFIVLARCDDSRPWYETLPAVAMDYKVHIDAGKEDCYFQYVNPGATFFVSFQVLRGGDGKAGFAVRNQAGEIVLPYQWRASADYQDQSGTGGYYSVCVDNQFSRFAGKLVNLYITVIRYDQWDKFTKELEELNLSVENFTSTIVNVEKNINEMLHTQAISRSREARDLNLITENNSYVQNWSVAQVIVIIATTILQVYFVKKLFQERPTGSSKIRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HUI4</accession>
    <name>A0A8J2HUI4_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS13986</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5109350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HUI4"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5109350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="164" mass="18891" checksum="7CE1778F85A4621E" modified="2022-05-25" version="1">MGKGKGLLEKGVHVGHTGGDNVQGKAEGKRYLLAVSENSLNSVYLLGAVHNNLPSRKLPKNGDVLNYFMFKYKILKKTVRECAAEIIDEVQEIWSDMNTPLIKHQHAIKKMEMLFTEWRNLDKSRLKKHSEFHLLKIKKFTDKLNELFDVRLKKRPFGTSQDGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MAX9</accession>
    <name>A0A8J2MAX9_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS3059</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001117">
        <property type="protein sequence ID" value="CAG5079630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MAX9"/>
    <dbReference type="OrthoDB" id="7714045at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5079630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="334" mass="38079" checksum="B0D9276716B922CE" modified="2022-05-25" version="1">MSGNHLKIGQIFNSIDEVNEMIKNLRTVLNCEIKKGNSKRLKGVDETLIERLQYEYIKFQCPKSGLPESSVKDEDRQRQRESARTNCPFEEPPKKKIKRNRTDATTLSTEKIGNIDNLLPKGPDHMDELAVVTVSATNSINDEEFDSILHSLKNKLLLDVLNRRKYLKKLEDLLLYFKENDRSTFVFEKEKSTLEAFTKSRKFKNNNKNSSEENIENITLQKSEQALSERTDVYQESLTNSHPSDLDTANSNNVAGSNFMNTHANSVVIEKTLDINNDVDDKENASNHSDTDNAVNNDVEKEILSKSADDTNNQIGDSIEKEKKMIVFSINQCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MG23</accession>
    <name>A0A8J2MG23_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS2487</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001117">
        <property type="protein sequence ID" value="CAG5077524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MG23"/>
    <dbReference type="OrthoDB" id="6424487at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="38"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="121"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="180"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="270"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="38"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="126"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="138"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5077524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="351" mass="40352" checksum="96423ED964ECEAAF" modified="2022-05-25" version="1">MIVISSAISNNRLAVSSSSLNNRRKMNIVSRGTVTTMEVNKGSRSTKNVSPRVESNPVARKRRMDELPLSKIPKAPRRDSKDDECTVSSNSVSLKELTGTSSTDMLTDSRCAVNNREISSSAITTVDDDDDDDDDEENLQKDSRDSIIVKNKPPIHPDIPHKRLISVNRRDDSTRLRKTIQWLEEGARKLREDLADARAELHEEKKSAKMARRDIEKAVKKARNQEAKKYQNIIADLRARLTKNPFQVSLDNSTSLQSEQSKDDNQRCEILVARKRRAELNQTIENLNSDSSDSDDCTKRKRKYSNEAELRTIECEIRNSQMVNEELEQNLQVKKFLFRQRNLKFRIEYFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MIK5</accession>
    <name>A0A8J2MIK5_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS3792</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5083285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MIK5"/>
    <dbReference type="OrthoDB" id="6606299at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="72"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="20"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5083285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="290" mass="32827" checksum="72D69B8409F49D89" modified="2022-05-25" version="1">MTGKRRHQIIEESSEDSDYSYDNSSNAASNPGSVEQSEFQKRKRGRGPSKRPCLNRNALMARANRQKKKEYVEHIESKLMHYRQEIKELTTKNQKQCIDLKRLTAEVSYLKNILNNNSSITSLLKSMNEILSRGGRKGKGKEGESAKSICEKEADEKGVNYNPDNGQVSIKESSQDSIKIYNEFNKSPVESIDNIDLGISDTDLDQLNSIDLFSQLSDDLEDNEPIDFLKSQNSTVESLDLFNNLDNNGLEAAAVLFLEIWNIRQHKIKVGVSLTIIKKVSILNLNLKQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MJP4</accession>
    <name>A0A8J2MJP4_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HICCMSTLAB_LOCUS4703</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5088075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MJP4"/>
    <dbReference type="OrthoDB" id="6581954at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035725">
        <property type="term" value="P:sodium ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000175">
        <property type="entry name" value="Na/ntran_symport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002438">
        <property type="entry name" value="Neutral_aa_SLC6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037272">
        <property type="entry name" value="SNS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11616">
        <property type="entry name" value="SODIUM/CHLORIDE DEPENDENT TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11616:SF182">
        <property type="entry name" value="TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00209">
        <property type="entry name" value="SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00176">
        <property type="entry name" value="NANEUSMPORT"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01206">
        <property type="entry name" value="ORPHTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161070">
        <property type="entry name" value="SNF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00610">
        <property type="entry name" value="NA_NEUROTRAN_SYMP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50267">
        <property type="entry name" value="NA_NEUROTRAN_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0915">Sodium</keyword>
    <keyword evidence="5 10" id="KW-0769">Symport</keyword>
    <keyword evidence="4 10 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="114"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="145"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="239"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="269"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="314"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="351"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="505"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="539"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="580"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="623"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="82"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="12"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="41"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="122"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="124"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="125"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="129"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="325"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="357"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="476"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="479"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="480"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR600175-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAG5088075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="718" mass="79767" checksum="48B7B06A9BA4432D" modified="2022-05-25" version="1">MANTAHLVRRQSSRDLKPQKSVDRLEMKEMRGRLVVDSRKNPTTNYGTTNPGFDDSSPSIKAKKPNAPAHVSVNVSSSIVESTAPKMPTGSTEGKGIFRPEAGEDERENWDSKLTFLLATVGYAVGLGNVWRFPYLAQKNGGGAFLIPYFVSPYLGGIGISSAVVSFNVALYYNTIIAWCLFYFVQSFQSELPWSECPNKYFQNGSYAPEPECQESSPTQYFWYRTTLMISKDINTPEVFNWKIALALVIAWILVYMCMIKGIASSGKVVYVTATFPYLVLIIFFFRGVTLPGMSDGLRHLFTPKWYTLTDPVVWLEAGTQIFFSLGLAFGGLIAFSSYNPVNNNCYRDAIMVSLTNCFTSMFAGIVVFSVIGFKATMVYEKCLVDRNSTLIGIFGHPERFPDEIPPAGTLLNFTNGNNSVDNIIMPEIPECDLQKELDNSASGTGLAFIIFTEAINQFPGAQFWSVLFFLMLFTLGIDSQFGTLEGVVTSIVDMKLFPNLRKEILTGAICLVCCIISMAFAHGAGSYVFVLFDNFSGNFPLLIIAFFECIGVSYVYGLRRFADDIELMTGNRPGLYWLICWKYLSPLAMLTILVASFVEIICEGSGYQTWVPNKGSTERQEWPTWALVLIFILILASVLWIPAVAIFRLLGIPIIDDNEKAWFPAEDLKEFHGIVPHEVTAAEKLLFCIRADGSEGMCCPTGGLNDDDDDIDNGNLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MK71</accession>
    <name>A0A8J2MK71_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS5111</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5089115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MK71"/>
    <dbReference type="OrthoDB" id="2155935at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="73"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5089115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="133" mass="15472" checksum="5E88F842814BAC24" modified="2022-05-25" version="1">MRTRVFRRSHLPPVKSNYGQDELYRSFINFFHGHEGLFRKVYVRDDDSVGKNQEQLESPDDTNHLEVNNEIETSVKISDENNMNNSTDNDKNKVVENPEAEKDAQKNPKRPSGSKPHLRSSKRIKKKLSDFIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MKR2</accession>
    <name>A0A8J2MKR2_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Similar to Pip5k1a: Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha (Mus musculus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HICCMSTLAB_LOCUS8376</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5096769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MKR2"/>
    <dbReference type="OrthoDB" id="70770at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016308">
        <property type="term" value="F:1-phosphatidylinositol-4-phosphate 5-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.800.10:FF:000001">
        <property type="entry name" value="phosphatidylinositol 4-phosphate 5-kinase type-1 gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.800.10">
        <property type="entry name" value="Phosphatidylinositol Phosphate Kinase II Beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002498">
        <property type="entry name" value="PInositol-4-P-4/5-kinase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027484">
        <property type="entry name" value="PInositol-4-P-5-kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023610">
        <property type="entry name" value="PInositol-4/5-P-5/4-kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23086:SF101">
        <property type="entry name" value="LP03320P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23086">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-4-PHOSPHATE 5-KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01504">
        <property type="entry name" value="PIP5K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00330">
        <property type="entry name" value="PIPKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56104">
        <property type="entry name" value="SAICAR synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51455">
        <property type="entry name" value="PIPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PIPK" evidence="4">
        <location>
            <begin position="36"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAG5096769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="229" mass="26175" checksum="50F0EF87BCAAEC94" modified="2022-05-25" version="1">MDKNESSTENGLVRASQIQRALTVSTSRDLAREWIQTTQIMGSIQLGIQHAVGGLASKPERDLLMQDFMTVETTNFPSEGSNHTPAHHFSEFKFKNYAPIAFRYFRDLFGIQPDDFLMSMCSAPLRELSNPGASGSIFYLTEDDEFIIKTVQHKEGEFLQTLLPGYYMNLNQNPRTLLPKFFGLYCYRCNSKNVRLVAMNNLLPSAVKLHQKYDLKGSTYKRKVTFFCN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MKS6</accession>
    <name>A0A8J2MKS6_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similar to slo: Calcium-activated potassium channel slowpoke (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS5625</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5090424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MKS6"/>
    <dbReference type="OrthoDB" id="10035564at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034220">
        <property type="term" value="P:monoatomic ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0407">Ion channel</keyword>
    <keyword evidence="2" id="KW-0406">Ion transport</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035153162" evidence="1">
        <location>
            <begin position="18"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5090424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="76" mass="8433" checksum="D6BE6D752ED93197" modified="2022-05-25" version="1" fragment="single">LCFTKLKLLLLAIEIKGEGGADSKISINPRGAKIAANTQGFFIAQSADEVKRAWFYCKACHEDIKDETLIKKCKCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MKX8</accession>
    <name>A0A8J2MKX8_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similar to PABIR1: PPP2R1A-PPP2R2A-interacting phosphatase regulator 1 (Homo sapiens)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS8392</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAM122 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5096801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MKX8"/>
    <dbReference type="OrthoDB" id="10036177at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004865">
        <property type="term" value="F:protein serine/threonine phosphatase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026716">
        <property type="entry name" value="PBIR1/2/3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22227">
        <property type="entry name" value="FAMILY WITH SEQUENCE SIMILARITY 122B ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22227:SF6">
        <property type="entry name" value="FAMILY WITH SEQUENCE SIMILARITY 122B ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5096801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="325" mass="36246" checksum="ED9B1FC8E9724C6E" modified="2022-05-25" version="1">MLKIKQEKIPLTMEVDCPIISLKRSSSAPMIHEISATVSVSSSTTSVPRDVASSLNLFPNISRTRRFSTSSSVNIPRLTPRVNQLKQEECIDVAGREAAHEKEIHSAMQISQSWEDLTLDAEGLSVKDSDLSSHQLQNIEKQMIKKFVDPLNLNLPVVNNTSFCSSPSPTRSSLGQRQCYSPGLSTVQWKNNLSPSPTRKSFAMRRSLSPIALRPSCLGPVKRKFDLDNNCVDRQRPIKRTSALVLSNSSRSDEISNITPETIDLVESSGSFSNINGSDFSFHSVDETVSHRKVINENQQMSINAEQSRITRSKQIDQINQSNYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2ML57</accession>
    <name>A0A8J2ML57_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">aralkylamine N-acetyltransferase</fullName>
            <ecNumber evidence="5">2.3.1.87</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">HICCMSTLAB_LOCUS6019</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>dopamine + (9Z)-octadecenoyl-CoA = N-(9Z-octadecanoyl)-dopamine + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:51380"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:31883"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57387"/>
            <dbReference type="ChEBI" id="CHEBI:59905"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:51381"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>dopamine + acetyl-CoA = N-acetyldopamine + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:51388"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:59905"/>
            <dbReference type="ChEBI" id="CHEBI:125678"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:51389"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>dopamine + hexadecanoyl-CoA = N-hexadecanoyl-dopamine + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:51376"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:59905"/>
            <dbReference type="ChEBI" id="CHEBI:134058"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:51377"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>serotonin + (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA = N-[(5Z,8Z,11Z,14Z)-eicosatetraenoyl]-serotonin + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:51396"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57368"/>
            <dbReference type="ChEBI" id="CHEBI:132255"/>
            <dbReference type="ChEBI" id="CHEBI:350546"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:51397"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>serotonin + (9Z)-octadecenoyl-CoA = N-(9Z-octadecenoyl)-serotonin + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:51392"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57387"/>
            <dbReference type="ChEBI" id="CHEBI:134064"/>
            <dbReference type="ChEBI" id="CHEBI:350546"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:51393"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>serotonin + acetyl-CoA = N-acetylserotonin + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:25217"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17697"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:350546"/>
            <dbReference type="EC" id="2.3.1.87"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:25218"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>serotonin + hexadecanoyl-CoA = N-hexadecanoyl-serotonin + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:51384"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:134059"/>
            <dbReference type="ChEBI" id="CHEBI:350546"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:51385"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>serotonin + octadecanoyl-CoA = N-octadecanoyl-serotonin + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:51400"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57394"/>
            <dbReference type="ChEBI" id="CHEBI:134065"/>
            <dbReference type="ChEBI" id="CHEBI:350546"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:51401"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Aromatic compound metabolism; melatonin biosynthesis; melatonin from serotonin: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the acetyltransferase family. AANAT subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.87" evidence="5"/>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5092290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2ML57"/>
    <dbReference type="OrthoDB" id="41532at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004059">
        <property type="term" value="F:aralkylamine N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000046">
        <property type="entry name" value="Dopamine N-acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20905:SF1">
        <property type="entry name" value="AT07410P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20905">
        <property type="entry name" value="N-ACETYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="14">
        <location>
            <begin position="51"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="15">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00037926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00039114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00050189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00050849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00051284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00051711"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00051823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00052178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00052335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00052491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CAG5092290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="138" mass="15712" checksum="21E539601F2770DA" modified="2022-05-25" version="1" fragment="single">TTVKPEDTDEPDFIKNCDNFKFKKILRLLHHVDRKAAVLDRYPGSKILDVKIISVDSGCRGKGIAAALCQKTVDIAKELNYNYIRTDASSHYTAKLCKRLGFEQIFELMYKDYVDSNGKSIFTPAYPHSCISTFIKKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MM10</accession>
    <name>A0A8J2MM10_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS8545</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5097107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MM10"/>
    <dbReference type="OrthoDB" id="10524610at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5097107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="526" mass="61765" checksum="E97FCDAEA4E62708" modified="2022-05-25" version="1">MEEYHPGDTINIYSQNNYVISKIFNGFSGAKYIKIENVSRTNGYEIFYESCLPFESLDQYLYPDVFIDQKKSSSVSSKLFHYIKQLRNSNLNVKSFYIDNHKFLYGIVKLCKTVETKNLNIKLINRNHFPKFYEYGSHNILMNETILFRLKQDNETHYISSVNIGTCLFQIYVHQWTACDSETKKKFNHYESFFQDAIYKTPFITVSYNHELENSINGYYFLHNIEYSLHKFRQLEWNHQNSILNMFGKNSVVYLELQTLAELPHTVKPKNQPLTVKLIHKAKLKDLHPGYLLNLNELLGNNSDHVSIKNILTGTNNFYTTNPFVESNYLNCSDLNESESPSFGTKKFNIFYEIIKHQNYGVDRIYLNQLKTCLKIIVCSKMFHEEFYIPKVEIIKLNQGTRNNFKKNIFENKNIITMYLEGNETHFINHTEKGECLVQVIVFPFQFFNGFKYSSHNDSPVYMGKILSASNNETLKTLAGNLFNNDLRSIIEPKKKDFPLNALYVELNKSTQIKKTLLSVYLNELY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MMB9</accession>
    <name>A0A8J2MMB9_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Small ribosomal subunit protein uS12m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HICCMSTLAB_LOCUS8740</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the universal ribosomal protein uS12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5097513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MMB9"/>
    <dbReference type="OrthoDB" id="361013at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03368">
        <property type="entry name" value="Ribosomal_S12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000115">
        <property type="entry name" value="28S ribosomal protein S12, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006032">
        <property type="entry name" value="Ribosomal_uS12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005679">
        <property type="entry name" value="Ribosomal_uS12_bac"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11652">
        <property type="entry name" value="30S RIBOSOMAL PROTEIN S12 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00164">
        <property type="entry name" value="Ribosom_S12_S23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01034">
        <property type="entry name" value="RIBOSOMALS12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00055">
        <property type="entry name" value="RIBOSOMAL_S12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG5097513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="158" mass="17687" checksum="7EB3E120A52DB9AE" modified="2022-05-25" version="1">MSVIAKGFVNLFRSQIGKSIEASNAWSLTKSCVNNAFTGFAEFKRFGSSLFQMHKKGPHCKKRNKQRPFNGNPFAKGVVLKTLIKKPKKPNSANRKCVLVKLSNGREMVAYVPGIGHNLQEHNIVLCRVGRLKDTPGVKIKCVRGKYDLPHVIKPEQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MMH8</accession>
    <name>A0A8J2MMH8_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS8060</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5096139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MMH8"/>
    <dbReference type="OrthoDB" id="6358449at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="26"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5096139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="89" mass="9969" checksum="6C1A4419150D24A2" modified="2022-05-25" version="1">MMYSPDKMMGSKGLHGTPISAPGCFPSGRYSPPSYRSGPESMPPPPPPRRCMPNPGFCFMNVAKTCGYKKLSLLEPRTFFEQPKLLWRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MNC5</accession>
    <name>A0A8J2MNC5_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similar to stmA: Protein EFR3 homolog cmp44E (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS9635</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the EFR3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5100562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MNC5"/>
    <dbReference type="OrthoDB" id="19232at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072659">
        <property type="term" value="P:protein localization to plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049152">
        <property type="entry name" value="EFR3-like_ARM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051851">
        <property type="entry name" value="EFR3_Homologs"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12444">
        <property type="entry name" value="PROTEIN EFR3 HOMOLOG CMP44E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12444:SF8">
        <property type="entry name" value="PROTEIN EFR3 HOMOLOG CMP44E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21052">
        <property type="entry name" value="EFR3_ARM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5100562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="763" mass="86800" checksum="8445C53A0F688AD2" modified="2022-05-25" version="1">MEKLTFYSLSSPEKLDRIGEYLFQRASRDIYRRRNGFVVIAMEAMDQLLLACHAQTLNLFVESFLKMIQKLLESTDPQLQILATQSFVRFANIEEDTPSYHTRYDFFVSKYSAMCHANNDNLETRKQIRLAGIQGLQGVVRKTLSDDLVENIWESVHMDKIVPSLLYNMQTARYVEKENSTPDSPTEERSNPPQFAETCMRELVGRASFGHIRCVIRPVLRHLDNHQLWVPNYFAIHTFRIIMFSIQSQYSYTVVEALMTHLDDNSKSSPKIRTSIADTLSKIIAIAAGESVGPSVLEIINSLLSHLRISVTRNQYSSNDEQLYQEALINALGEFANHLPDYQKIEIMMFIMSKVPCSQPDRFITVGKGDVLLQSILLKSLLKVGTKYQTIHLNTTFPPSFLEPLLRMSLVADAEMRLLVQKIFHTLIDRHHNINKLTKPTLNILELDLVVNKSSRPDVIFIRKHGPEIYLALYESIELSSNTVENIEAIYTTLALLIVELASEETVLEQLRLILSLQDLAIVNSQLSTTLKLNLHAIVVSLLILISHVCSLTYLIDYVEKIITAREKEGIHLLPPLKSDYDDDLPTKFSSSMLVDQSIVTECLKMAGFDAGKLQQGSKYNSNSLQHRHSWVDTAGRTSITDINSGSVELDSGGSSPGTQKKMMVEELTFESMKKILTESSNIQNEDEEKRIQLSEYFRNASFQDLILKTQPQHDVLQSKLSDIFNSLTVEPRNLSQQNIQAIDPKSTPTPAYEIHFPELFVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MPS1</accession>
    <name>A0A8J2MPS1_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS4764</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5088217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MPS1"/>
    <dbReference type="OrthoDB" id="2095648at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5088217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="368" mass="43272" checksum="2CAAD475AA94B546" modified="2022-05-25" version="1">MSALELLPLEIWEKVISRINDPKKLVKLRQVCSVFNQLIEIEMKKNKEWKGLLPNDMQMWINNILAKKYPFKKPSNLKLIPNLWKEVFFSYKNWRLFGDKSRKIHSFRLNVSQFSQNENITCLTTFAHLIAVGTNLGSIFFYKIGKSKNFFWAAKHGSSLTKVQFWYQGKNNLLALSISRDRALKFWNVSQRKSIVTPHYNATNIHVGITHRLFIEFFRGITECKYKSNRVVLRAHCAVFQDDNGPRNNFLTMYSEKKKLIVMTTYDIILRVITLGVPGPRGTELTKISNIPYRLMPRRPPVDLALIPNKKLRLFKNGKFFTIILQDWPNFPVYDYELYRYDEDIFVTSIAMHEPFVMEQAHDYNAGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MPZ7</accession>
    <name>A0A8J2MPZ7_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Similar to LRR1: Leucine-rich repeat protein 1 (Homo sapiens)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HICCMSTLAB_LOCUS4946</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5088697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MPZ7"/>
    <dbReference type="OrthoDB" id="17912at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050216">
        <property type="entry name" value="LRR_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057437">
        <property type="entry name" value="PIF1/LRR1_PH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051:SF52">
        <property type="entry name" value="LEUCINE-RICH REPEAT PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25344">
        <property type="entry name" value="PH_LRR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00364">
        <property type="entry name" value="LRR_BAC"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="PIF1/LRR1 pleckstrin homology" evidence="4">
        <location>
            <begin position="1"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF25344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAG5088697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="426" mass="47818" checksum="30120F0E66738EC0" modified="2022-05-25" version="1">MKLVCNVEVNHRGLLAGSNVTRKKSQQSCLSIGKQCKKDELFIFLQSKPHSGNQIINKYKIDDNIENIFTKFINDGKSTIRFKEPPVDLNIKSNDALQLKSFLKALQLGFNKKLSDDTVVKLKDLNSKTNSFPVSTAKKKVFVRSKAEYPVLEGFPRTTEELHVSGLGRKSFDRQMLRLQSLRILNLSNNAISSVPKELGNVFACLTELNLASNLLGETPGVVNNYQSIKNKWLWLNGTSITKTLRLLDLSDNNQVGKLKGLVTLNVSSNKLETLPESIGVLPRLKYLDLSMNNLKSLPGSFRNLQLDTLNVTKCFSPIPQPESTEETTYIMSLKELAARVVVNKQIYYDASIVPATLVDYMDNAHYCSMCGSSCFEEVIRKYTLKNLRSIAHAITSDVHIATADTLFNCILCSFRCSYIFKKRGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MR78</accession>
    <name>A0A8J2MR78_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Similar to Mllt10: Protein AF-10 (Mus musculus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HICCMSTLAB_LOCUS11315</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5103049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MR78"/>
    <dbReference type="OrthoDB" id="20839at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031491">
        <property type="term" value="F:nucleosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15672">
        <property type="entry name" value="ePHD_AF10_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15574">
        <property type="entry name" value="PHD_AF10_AF17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000042">
        <property type="entry name" value="protein AF-10 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000053">
        <property type="entry name" value="protein AF-10 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049781">
        <property type="entry name" value="AF10/AF17_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034732">
        <property type="entry name" value="EPHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050701">
        <property type="entry name" value="Histone_Mod_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13793:SF164">
        <property type="entry name" value="ALHAMBRA, ISOFORM P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13793">
        <property type="entry name" value="PHD FINGER PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13831">
        <property type="entry name" value="PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13832">
        <property type="entry name" value="zf-HC5HC2H_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51805">
        <property type="entry name" value="EPHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="10">
        <location>
            <begin position="22"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="11">
        <location>
            <begin position="79"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="212"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="363"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="513"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="613"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="247"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="272"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="286"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="377"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="521"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="566"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="613"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="665"/>
            <end position="680"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAG5103049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="689" mass="73622" checksum="6C853887E7F64031" modified="2022-05-25" version="1">MFLQLTASLISNRPEHSMKEMLGGCCVCSDERGWTENPLVYCDGQGCTVAVHQACYGIVTVPTGPWYCRKCESQERSARVRCELCPSRDGALKRTDQAGWAHVVCALYIPEVRFGNVTTMEPIILQLIPSERFNKICYICEEQARGSRATVGACMQCNKTGCKQQFHVTCAQALGLLCEEAGNYLDNVKYCGYCQHHYSKLKKGGNVKTIPPYKPIPADNGSSDSSPEKEIDLPSKTSTTVKRKSSNLKSSTTLNLKNKLNTSPSLDVDGVIDEKNGSDRNIPKDATSSSTPGSSKFTTSNFVETVVTQSESVFGHENSSSSTISSDLVSTGGVKPGTNINFTHKNNNHPKSSSSINKLNYSSKKRKTGTHTPTAIGSENSNNSVSSEASGSVVTVSSIIQSIASNSVQPTVTEATSLSTVSELEKLKLTSDNSLNSNTSNISTTNVSTTTPVIISSPSTQTHTTTTATSIVVSVPLTATSLPNFAQTVVTSAPTLYQQLQQSMSTIAVTNNDQSDSVTYPDHDPPEDSPAKKLRLQSTDKQEKVRKTKRGSTLNNPSLSIPPVPVSSISSSTSSTTISIVKTSKRNLARNNSQTQSLSVAPISSIIQGTTTATGNFSSITSATGSTMRSVVKDSPPSSPSSESMSSTGPGRRKKKSVEDHDSITPLSSINMTPTPLASNTKEEKEVKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MRC1</accession>
    <name>A0A8J2MRC1_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Similar to lbx1: Transcription factor LBX1 (Xenopus tropicalis)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HICCMSTLAB_LOCUS12054</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5106014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MRC1"/>
    <dbReference type="OrthoDB" id="6159439at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990837">
        <property type="term" value="F:sequence-specific double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000098">
        <property type="entry name" value="Transcription factor LBX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020479">
        <property type="entry name" value="HD_metazoa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000047">
        <property type="entry name" value="HTH_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051892">
        <property type="entry name" value="LBX_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24336:SF8">
        <property type="entry name" value="LADYBIRD EARLY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24336">
        <property type="entry name" value="TRANSCRIPTION FACTOR LBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00024">
        <property type="entry name" value="HOMEOBOX"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00031">
        <property type="entry name" value="HTHREPRESSR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="3 6 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 6 7" id="KW-0371">Homeobox</keyword>
    <keyword evidence="5 6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="9">
        <location>
            <begin position="19"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="6">
        <location>
            <begin position="21"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAG5106014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="124" mass="14534" checksum="9DBC5060CEE1EDCF" modified="2022-05-25" version="1">MISEQANHLNLFNNRQQPKKKRKSRTAFTNQQIFELEKRFLYQKYLSPADRDEIAAQLGLSNAQVITWFQNRRAKLKRDLEELKKDVQTVNPLLVAQHKTFLENAQDLGILKKRPLPSSIDDKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MRF0</accession>
    <name>A0A8J2MRF0_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Venom serine protease 34-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HICCMSTLAB_LOCUS11496</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase S1 family. CLIP subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5103413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MRF0"/>
    <dbReference type="OrthoDB" id="6380398at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000068">
        <property type="entry name" value="transmembrane protease serine 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000859">
        <property type="entry name" value="CUB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051487">
        <property type="entry name" value="Ser/Thr_Proteases_Immune/Dev"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035914">
        <property type="entry name" value="Sperma_CUB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24256">
        <property type="entry name" value="TRYPTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49854">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01180">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035260597" evidence="4">
        <location>
            <begin position="22"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="5">
        <location>
            <begin position="26"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="6">
        <location>
            <begin position="149"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00024195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAG5103413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="391" mass="42942" checksum="2388C0D113935DDF" modified="2022-05-25" version="1">MLSRELSPLMFLLVLTGMSNAQFDGCNYEQTLNPGQTYYIYNPNYPNDESAPMNSCRWIVNSDRLIKMNCSISLPESPYCKSDAFILQTSATNQGERYCGTGPIDVHAEDGNRIIVSSHLSAGRFLCEVRSDSDNNNECSCGWKNPTRIVGGVSTGVNEYPMMAGLIDVINQNVFCGSTIINTQQVLTAANCVNGRSSNTVGVMIGDHDISKTTDTNATKLYKVASIIIHPEFSTDFLDYDIAVITIDGTMIYSHQVGPACLPFQHSLDSFGGNYVDLLGWGLTEFGGRQSPVLQDARVSVITNKICMETYSEIGSRQLCTLTDGKDSCEFDSGGPVLWENPTTKNIVLVAIIGYSRLCADEKPSVNSRVGAYIDWIRTQAPQGYQYCENE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MT36</accession>
    <name>A0A8J2MT36_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Similar to Corin: Atrial natriuretic peptide-converting enzyme (Rattus norvegicus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">HICCMSTLAB_LOCUS13279</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5108521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MT36"/>
    <dbReference type="OrthoDB" id="5985572at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07066">
        <property type="entry name" value="CRD_FZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00112">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000235">
        <property type="entry name" value="Atrial natriuretic peptide-converting enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.2000.10">
        <property type="entry name" value="Frizzled cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.400.10">
        <property type="entry name" value="Low-density Lipoprotein Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.960">
        <property type="entry name" value="SEA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020067">
        <property type="entry name" value="Frizzled_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036790">
        <property type="entry name" value="Frizzled_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036055">
        <property type="entry name" value="LDL_receptor-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002172">
        <property type="entry name" value="LDrepeatLR_classA_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000082">
        <property type="entry name" value="SEA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036364">
        <property type="entry name" value="SEA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24258:SF146">
        <property type="entry name" value="ATRIAL NATRIURETIC PEPTIDE-CONVERTING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24258">
        <property type="entry name" value="SERINE PROTEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01392">
        <property type="entry name" value="Fz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00057">
        <property type="entry name" value="Ldl_recept_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01390">
        <property type="entry name" value="SEA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00261">
        <property type="entry name" value="LDLRECEPTOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00063">
        <property type="entry name" value="FRI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00192">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63501">
        <property type="entry name" value="Frizzled cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57424">
        <property type="entry name" value="LDL receptor-like module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82671">
        <property type="entry name" value="SEA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50038">
        <property type="entry name" value="FZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50068">
        <property type="entry name" value="LDLRA_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50024">
        <property type="entry name" value="SEA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="58"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="SEA" evidence="11">
        <location>
            <begin position="92"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="FZ" evidence="12">
        <location>
            <begin position="240"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="13">
        <location>
            <begin position="553"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="240"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="248"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="371"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="409"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CAG5108521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="782" mass="86699" checksum="555A76BAFD84D88B" modified="2022-05-25" version="1">MGAFSESPAGNCKREGKLICSISVSTVSTRRFSRAGTPSSILSSDSDIRFTRKLGGQYRCGCCVLAAFLLFLLFSGVSIYLGYHLLTSDPPGDQVFLASFRVVDGDSFTIDLADPSTEAFRIRAREYRDRINLAFRRSNLRISFIASEVLALDGVENSDLVVHLELRFDPRYQTLKVPDIVQVLSKEINSTTARYLVNLTIDPKSLEVQENLAALNAQVAISTTVTTPMTTTATPPPRSCSPLELTYCKHLSYNITSYPNIFGHQSLVEVEEDVIAFRELVDAECYRLAYDFVCQVLQPACVEGTPEATIKLPCRSFCREFWSGCGNRLPDRIKNALDCSNFPEYADEGSCKPKPGCVRDLQNKALSPRICDGIVDCPDLSDEKNCAYCQEDHMHCGIGRTCIPTSKRCDGKADCPNGLDEKDCLFLAQSVSSVKNQPIDTPLSVKYTHEGYVIFNEKGTVGKLCIENLNATLPQTEMDTVLQTAAASLCTLLTYNGMSSVEMRIDDEEDVEYVHMEDPLASEISFVRAPCPSKQVMYVRCAELECGIQALKTKTGTKVLNKIAEPGDWPWHVALFKEDTHVCDATLVSSNWLLTTASCFQGQPKAEWSARLGTVRLSSTSPWQQERRIVGMVKSPVEGSTIVLLKLDKPVIVYSDLVRPICLPSSQEFMQLNTSHCNTLGWARNRDLLQRVQLKYSAMEKCENISIASVNGICTDAVYSTDDCNEEELAGTPMICLLPDERRWALAGVSSWRIACSKAAIERPRLYDKVSSNIAWIKSTIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MTV7</accession>
    <name>A0A8J2MTV7_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to Pcmtd1: Protein-L-isoaspartate O-methyltransferase domain-containing protein 1 (Mus musculus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS13842</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5109206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MTV7"/>
    <dbReference type="OrthoDB" id="10257972at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004719">
        <property type="term" value="F:protein-L-isoaspartate (D-aspartate) O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000682">
        <property type="entry name" value="PCMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11579">
        <property type="entry name" value="PROTEIN-L-ISOASPARTATE O-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11579:SF9">
        <property type="entry name" value="PROTEIN-L-ISOASPARTATE O-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01135">
        <property type="entry name" value="PCMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="314"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="394"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="452"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="520"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="621"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="329"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="401"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="459"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="469"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="549"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="621"/>
            <end position="634"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5109206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="695" mass="78962" checksum="58BB6ABA42FE2BD8" modified="2022-05-25" version="1">MGNVTSGENNEDLVDILKILGYIKTKRVERIFRAVDRGDYVLPSHRSEAYKDLSWKMGNIHLSAPCIYTKVMEGLSLEPGLSFLNIGSGTGYLSTMAGLILSRNGTNHGIELNNDCMEYAYEKLEEFKQKSLALDEFDFCEPVFIQGNCLKLECTRKYDRVYCGAACPESHEAFIKQFVKIGGILVMPYKDHLLRIERVDTDSWKHRVMLPVLFAPLIMPTSNCIYNNSGDDHDNTTDKVNDCPNSSLLLPFSEPLSLQELCRCEIRCQLRKNIWAEHPELEVNYPITGLNRSGPNAYHPITAQTTLPRYVMPLYDESSDNSPYITLNDDYDDDDDEDEDDDNVDNNDDEDNLDNNNDDDDDDNNNDNDVNNKDRSLKIRHRRNRKTRLFFCLEPSRLENEPNEEEDEDEGNNNDDNDDNDDDDEIEQVTSFRVLKNVSPKKSILNIFNFDKSTINNDDNNKTKDQKLSENAFQPSTSQYLSQGCSNNDNNQENSNDILFTSAKGSLDSLLCYSNSQINSDSQANEETMDVDKEQQDSTDENFQVADGTKSSILNPSSTSTNNIRNGITTADNNEANSNTSGYQEILDASNGIDNNGDDSMECLNLMKSRHQQKNNKWGISDHLNSAENHPSLSKRSKVNDIENNDDNSRENRPHPRVCGYNVDIESLSSHMKTKISQLPLPVLLRLYINYNRSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MTX6</accession>
    <name>A0A8J2MTX6_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Tyr recombinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS13888</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5109252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MTX6"/>
    <dbReference type="OrthoDB" id="7700475at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="entry name" value="Intergrase catalytic core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35617:SF3">
        <property type="entry name" value="CORE-BINDING (CB) DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35617">
        <property type="entry name" value="PHAGE_INTEGRASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="DNA breaking-rejoining enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="34"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="129"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="42"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="146"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="170"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5109252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="478" mass="53857" checksum="66976D689FB127CB" modified="2022-05-25" version="1">MPKKRSRSRSRDSSVSTESFDYLQKKVQKYERKLAKKMRRDKSREDRQRQKELEDQRTNKDNAQSSYLGLYHALSILFDYVCIYIQSHEFPLRKEISYTGQFVELSELLNYKIHLVAIFCFSENDTSQTETSEVVTPKEVPEVSTKETPNQTTPGDGSEETEPTPLESVTGLSTESNINKTQEVADQVQKEKEVVTIDLDKDILEILGDDPTNEIKYGPEIHKEIATRFEHIATLGLSKENRKEIMEKYLTPANCTRSGAPLLNPEIKAAISETVIKRDKGIEAKQKQLATAIAGLGKVISAQMCATNRDTELVKDLMNTGRILCDLQHAESDQLTDNKIDKFLFGENLAETLKAAKAVSKSSTALTAYIRRTKDLRSTKDLFISYRKPFGTVTTQTISRWIKLTLKDSGLDVTTFSAHSTRHASTSKAHKLGVNIDEIRKTAGWSGTSNTFGKFYNRIIVAPNKGSLARAIINEPEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MW99</accession>
    <name>A0A8J2MW99_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similar to yjbQ: UPF0047 protein YjbQ (Escherichia coli (Strain K12))</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS9638</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0047 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5100565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MW99"/>
    <dbReference type="OrthoDB" id="10255963at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.460">
        <property type="entry name" value="YjbQ-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001602">
        <property type="entry name" value="UPF0047_YjbQ-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035917">
        <property type="entry name" value="YjbQ-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00149">
        <property type="entry name" value="TIGR00149_YjbQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30615">
        <property type="entry name" value="UNCHARACTERIZED PROTEIN YJBQ-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30615:SF8">
        <property type="entry name" value="UPF0047 PROTEIN C4A8.02C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01894">
        <property type="entry name" value="YjbQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004681">
        <property type="entry name" value="UCP004681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111038">
        <property type="entry name" value="YjbQ-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01314">
        <property type="entry name" value="UPF0047"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5100565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="170" mass="18848" checksum="63B4DDDDD44F6F9C" modified="2022-05-25" version="1">MASSNIGIQTGSAWFQRKINLRPQHRGVHLVTEEILRQIPELSQFSIGLCHIQILHTSASLALNESWDPDVRDDMEMMLNKIIPEEMPYRHSCEGPDDMPAHVKACFLGSSLSIPITDGKLALGTWQGIWFCEHRNNAGSRKLIVTLTGCLRDSTRSPLSPVSPIASTSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MXM9</accession>
    <name>A0A8J2MXM9_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Similar to Capr: Caprin homolog (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HICCMSTLAB_LOCUS11735</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the caprin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5103889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MXM9"/>
    <dbReference type="OrthoDB" id="10062814at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028816">
        <property type="entry name" value="Caprin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041637">
        <property type="entry name" value="Caprin-1_dimer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22922:SF19">
        <property type="entry name" value="CAPRIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22922">
        <property type="entry name" value="GPI-ANCHORED PROTEIN P137"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18293">
        <property type="entry name" value="Caprin-1_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Caprin-1 dimerization" evidence="3">
        <location>
            <begin position="98"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="325"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="420"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="428"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="449"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="468"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="479"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="531"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="552"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="579"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="631"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="642"/>
            <end position="660"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF18293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG5103889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="669" mass="73264" checksum="148C65B960649A79" modified="2022-05-25" version="1">MPSANPKLEKQASTEATDPIRQAITVIEHKIRNLEKRKGKLEALKDLQKNGKELNLDQKTAVAKYDEVLQTLEITRELYKQIVGISNDFAKQQKKQARKEALERMQQDISKIREVLLIQDVLINIGGEVVREDFLTGGNGAIKLTQDDLKFLDDFYNEVTMKRQLEPNDPPFMQQLQKAAEHYMGILEGKQREVAGTTYLRIKEIITSVQACGYFDQVQTVETEVITNEVALEAPVEVATGDGKNIVEQPSEEFTNNSGDVTIIPPPESMIPMPNFPVQVTPVAVVAGGAPVAGPMAVVTPQAIPAPHPPAPVETAYYANAAGYVPQPQQPQQPQPQQQQQQTPRINDVIGTPNFFFLQESELDPPEGAAGQPPTIVQHIPPPPVNAPIPTQTFTNQNFTGAPVQVPQQVIYQHAPQEMSHIPGFANPNPPPPIPMPPSHQQNIPYSPQHPAGQFQPPAPGQQAIQPTQNFDQQETQQSEEKPEQHAEETEVAPVEADPASEPVNWCQMADAPMDEWSNDNAQQSEHSDHQQSQQGWGEQRSSYRGRGGRRGNSNGYNSRGRGTGNYQQNGRGGGGQGSYYRNDNSNYQNGYQQRNYNNDGGSSNYNGGGFKRERGGANGGSGGPRTNSRGGDRVGIDRGGRGGQFRGGQRGGNRGGGYAPRGKPQTQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MY74</accession>
    <name>A0A8J2MY74_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS12550</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5107029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MY74"/>
    <dbReference type="OrthoDB" id="5599646at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039191">
        <property type="entry name" value="Nopp140-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23216">
        <property type="entry name" value="NUCLEOLAR AND COILED-BODY PHOSPHOPROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23216:SF1">
        <property type="entry name" value="NUCLEOLAR AND COILED-BODY PHOSPHOPROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="62"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="121"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="151"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="186"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="206"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="224"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="255"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="275"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="297"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="358"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="374"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="451"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="509"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="537"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="568"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="608"/>
            <end position="628"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5107029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="628" mass="66112" checksum="5CD21B9A883485B7" modified="2022-05-25" version="1">MASTDDFVISTLVYNYLLKKDSSIAKVFQTKTHVNPLPKGSPGIEEIVKHYQKSSPKKINIKAPAKSAKSDSSSGSEEEEVAKKPLVNGKAKAPASNKPESSSDDSSSEEEAKPVAKKPVAISKATPAKAPAKKEESSSEEESSEDEKAKPVAVKATPAKAPVAKKAKSSSEESSSDEDDKESKTKAVAAKPTPVAARIPLKPDSSSDDDSSDEEAPVKTVAHKPAAQATPKAAPKKAESSDDSDDSSEDEKPAAKPAVAKPTPAKTPAKKESSSEDSSDDDDEPPAKKVAPPKPAPVVQQKKVAANKGKASSSSEESSSDEEESPKKPVAKPTPAKTPAKAKESSDDSDSSDEEPAKPAMKATPAKQAKPAESSEDSSSDDDDDDDEEEKKPKQAPIVKTPAKKESSSEEESEEEEEKPKPKQKPAGVGEKRKREDSETNGVATPAKKANYSNFVKASNDGSTEKSRKNVPFRRVKDEEIKLSPQLANNSFEAKDGDGESSNNFDKQNGGGRGRGGFGGRGGRGGFGFRGGRDGDNGGFRGRGGGFRGRGGDRGRGGGRGGRGGFDNNRKSWDNKEGGGFRKSFGGDGDRRGGGNNFRGGQRKSFGGESNKSFNSTPTQNKKITFDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MYQ0</accession>
    <name>A0A8J2MYQ0_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Similar to Hexim1: Protein HEXIM1 (Mus musculus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HICCMSTLAB_LOCUS13112</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HEXIM family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5108187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MYQ0"/>
    <dbReference type="OrthoDB" id="10058500at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097322">
        <property type="term" value="F:7SK snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004861">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024872">
        <property type="entry name" value="HEXIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13469">
        <property type="entry name" value="HEXAMETHYLENE BISACETAMIDE INDUCIBLE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13469:SF8">
        <property type="entry name" value="HEXIM P-TEFB COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15313">
        <property type="entry name" value="HEXIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02094">
        <property type="entry name" value="HEXIMFAMILY"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0678">Repressor</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="278"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="250"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="17"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="30"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="47"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="63"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="81"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="282"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAG5108187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="370" mass="42120" checksum="53EDF2AB58C8A42C" modified="2022-05-25" version="1">MEETTSAPSGVEEMDDGDRLDNVRCEKNPTKSSDISCQKFESGSGSGDHELSHLDDGTDISAKKRKTRRGKPKHRKLKPYTKQQSYNHKLRIRSNSSRVVKKRTQPPAPYNTTQFLMDDHNDLPNLEQKLAGSNTEVQKIIQKPVVSRTRDSSFSVDSDEEYFYSSPEDEEEFLTKEFSSAYEDLHAERLSALSKSELIQEYIQLEAKLDILTKRLRNRTFQQTEERELDNKKSASLTAETSEFEMAKKLKICQQRIDDLIQQNDQLRRDIEALRGKRRKSSISSIDSESDSDSNSSCSCSDSDDSAKHQCTLRNVEHKISKKPMTISDSNNTEDTNISCSSRNRYLRNISSELTINSNTTTPNVGLLPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MZ19</accession>
    <name>A0A8J2MZ19_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Olfactory receptor 28</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HICCMSTLAB_LOCUS13611</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5108975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MZ19"/>
    <dbReference type="OrthoDB" id="7663575at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005549">
        <property type="term" value="F:odorant binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004984">
        <property type="term" value="F:olfactory receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004117">
        <property type="entry name" value="7tm6_olfct_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21137">
        <property type="entry name" value="ODORANT RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21137:SF35">
        <property type="entry name" value="ODORANT RECEPTOR 19A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02949">
        <property type="entry name" value="7tm_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0552">Olfaction</keyword>
    <keyword evidence="8 11" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="9" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="46"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="116"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="148"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="179"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAG5108975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="264" mass="30597" checksum="A33076DAE1931A2C" modified="2022-05-25" version="1" fragment="single">YTLWANRVDIFGVLQQFSILWIGIQTKVDLMYKIDPLLNISRKIRYSYIVTALFLGFSYALRPVIIMLTTYVGTTSGSNNTIDCSITTWPIEYPFVHQTISRYIPLLMYENLINHFAASYLICDALYIQLTTYLAINFMKIEFTYNPVFLATIVFNGINLCLCVIIVDKEISEGEWTLLMKSLIHAAVLATQIFIYCDFSHTVTETIDSIPISLYDSEWVDSTIKFKKMLVIILMQASKQYKFTAYNIIFQTTMSYFTLLRNFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MZS6</accession>
    <name>A0A8J2MZS6_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Acyl-CoA synthetase short-chain family member 3, mitochondrial</fullName>
            <ecNumber evidence="1">6.2.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Acetate--CoA ligase 3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HICCMSTLAB_LOCUS14085</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>butanoate + ATP + CoA = butanoyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:46172"/>
            <dbReference type="ChEBI" id="CHEBI:17968"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57371"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="4">
            <dbReference type="Rhea" id="RHEA:46173"/>
        </physiologicalReaction>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.1" evidence="1"/>
    <dbReference type="EMBL" id="CAJNRD030001762">
        <property type="protein sequence ID" value="CAG5110424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MZS6"/>
    <dbReference type="OrthoDB" id="1706066at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003987">
        <property type="term" value="F:acetate-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050218">
        <property type="term" value="F:propionate-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43347">
        <property type="entry name" value="ACYL-COA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43347:SF3">
        <property type="entry name" value="ACYL-COA SYNTHETASE SHORT-CHAIN FAMILY MEMBER 3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="5">
        <location>
            <begin position="2"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="6">
        <location>
            <begin position="154"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00040004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00042755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00047935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAG5110424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="211" mass="23578" checksum="A23BBD30712D4194" modified="2022-05-25" version="1" fragment="single">MKTIFVAGEHCDYEAKSWAENTFKVPILNHWWQTETGHAITATCQSLGHSLNPPKHCTGMPFPGYNVKVLREDGSKASAHELGRIAVKLPLPPGTMSTLYKAPERFKDIYFSKFPGYYDTMDAGYIDEYGYVYVTARDDDIINVAGHRLSTSALEDVVLSHPDIVDTAVVGVPEPTKGDIPLCLYVMRTDTTKNEEQINQELINKVRQLIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2E632</accession>
    <name>A0A8J2E632_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Elongation of very long chain fatty acids protein</fullName>
            <ecNumber evidence="10">2.3.1.199</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Very-long-chain 3-oxoacyl-CoA synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HICCMSTLAB_LOCUS1125</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a very-long-chain acyl-CoA + malonyl-CoA + H(+) = a very-long-chain 3-oxoacyl-CoA + CO2 + CoA</text>
            <dbReference type="Rhea" id="RHEA:32727"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:90725"/>
            <dbReference type="ChEBI" id="CHEBI:90736"/>
            <dbReference type="EC" id="2.3.1.199"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the ELO family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.199" evidence="10"/>
    <dbReference type="EMBL" id="CAJNRD030001116">
        <property type="protein sequence ID" value="CAG5074914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2E632"/>
    <dbReference type="OrthoDB" id="434092at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009922">
        <property type="term" value="F:fatty acid elongase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034625">
        <property type="term" value="P:fatty acid elongation, monounsaturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034626">
        <property type="term" value="P:fatty acid elongation, polyunsaturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019367">
        <property type="term" value="P:fatty acid elongation, saturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030148">
        <property type="term" value="P:sphingolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042761">
        <property type="term" value="P:very long-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030457">
        <property type="entry name" value="ELO_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002076">
        <property type="entry name" value="ELO_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11157:SF12">
        <property type="entry name" value="ELONGATION OF VERY LONG CHAIN FATTY ACIDS PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11157">
        <property type="entry name" value="FATTY ACID ACYL TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01151">
        <property type="entry name" value="ELO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01188">
        <property type="entry name" value="ELO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="5 10" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2 10" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="7 10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="63"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="93"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="116"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="151"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="180"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAG5074914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="208" mass="24180" checksum="D70E08FCD272FAAB" modified="2022-05-25" version="1" fragment="single">VMASLINSTATLIVPYNFAMAALNAYIAIQLFVASFKLSYSYVCQPIRNVWKAEELQIANAVWWYYFSKLLEFCDTFFFILRKKDNQLSFLHVYHHSTMFSLWWIGIKWVPSGSTFLPAMVNSFIHVLMYSYYGLAAFGPEVAKFLWWKKYLTILQLIQFTSALVLGINGIRSGCDFPLWMQYALVLYMISFIVLFGNFYAKAYIAKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2EB42</accession>
    <name>A0A8J2EB42_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS780</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001114">
        <property type="protein sequence ID" value="CAG5074008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2EB42"/>
    <dbReference type="OrthoDB" id="6371055at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062129">
        <property type="term" value="C:chitin-based extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008010">
        <property type="term" value="F:structural constituent of chitin-based larval cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050468">
        <property type="entry name" value="Cuticle_Struct_Prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000618">
        <property type="entry name" value="Insect_cuticle"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10380">
        <property type="entry name" value="CUTICLE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10380:SF234">
        <property type="entry name" value="CUTICULAR PROTEIN 97EA, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00379">
        <property type="entry name" value="Chitin_bind_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51155">
        <property type="entry name" value="CHIT_BIND_RR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0193">Cuticle</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="16"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="123"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="169"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="182"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5074008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="284" mass="31636" checksum="04491779136A0518" modified="2022-05-25" version="1">MLSAMLRWLEVQYQQPQAGSNNYEDYENGYNRRQEEAPQRNYANAPAPREGKAIAAKPTPPVAILKQINRHNEDGSYTYGFEGADGSFKIETKLANGEVKGKYGFVDDTGKVRVVEYGANQYGFQPSGEGITVAPPTLVDDTTDKNQQPIDYDYPQGPANFKQQEVQRPAPPPPPQQPRPQRPQYQPPQEYAAQPKTPIFTPAAQSQFSQQFDYEERPPVSQALNQGPVQFNPAPAREAQPSSLTRNVQRAAHNAGVLDQLAREYALPQDAAAPLHDISFGYYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2ECG7</accession>
    <name>A0A8J2ECG7_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phenoloxidase-activating factor 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Prophenoloxidase-activating factor II</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HICCMSTLAB_LOCUS1035</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001114">
        <property type="protein sequence ID" value="CAG5074354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2ECG7"/>
    <dbReference type="OrthoDB" id="5949700at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000038">
        <property type="entry name" value="Serine protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041515">
        <property type="entry name" value="PPAF-2-like_Clip"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24258:SF129">
        <property type="entry name" value="LP15124P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24258">
        <property type="entry name" value="SERINE PROTEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18322">
        <property type="entry name" value="CLIP_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035266468" description="Phenoloxidase-activating factor 2" evidence="7">
        <location>
            <begin position="22"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="8">
        <location>
            <begin position="465"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="138"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="262"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="151"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="265"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00068096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00076468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAG5074354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="717" mass="78069" checksum="E6758A2A6F5D4013" modified="2022-05-25" version="1">MEAKILVLMTVLVFKVQMIMGYDETRDFCTRWRSPPKFVRPSSNYTVNSTKRWSNINHSNSNVKNLDNNFILHILKHKLKLNHVPKIPTTTSVTTPDCFCVPWYQCDSNNTIISDGIGIIDVRIRRCTGDLEVCCKPPQMKPTTIMSTQPPTSPPTSPPTSPPTSPPTSPPTSPPTSPPTSPPTSPPTSPPTSPPTTLPPFPTLPPLRCMCVQIYQCGSDGFIITSGSGIIDPRQTSFLCSQCACEAPLVCCRIPPNSNQITSTIPPPPPPPSPPPTTTTPPPTSPTSTSTLPYKCVPISQCDPNGFIIVSGAGNIDPRYPARQISIVDNECGENQVRCYLPANGQDSIAFPDVPSFPSIDPRANFTIKNPGTSKACKCVKSTECQIGSEVQLDAAGFIDPRFRYCLPADQVCCKLDGIIIQAISTTLTSTTVKPFLPASNLIVNRFDSTASAQPFCGVKGPKCSTGNYSRQTYFGEFPWMVALIVKPTLTGINEFLCGATMINNRAVLTAAHCVLNRKPGPIIARFGEWDTSETKEPFPYQESIVQAIITHPQYYSGGLYNDIAILILESPVTYAANVMPACMPTQEMIFTPGTRCWATGWGRDAFQGKYQTLLKKIDLPLIDRAECQSRLRTTRLGQYFHLHTSFLCAGGEENKDTCTGDGGGPLLCSISSGQFVQVGIVSWGIGCGESQIPAVYTDVVKYRSWIDQQLANYGVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2ED36</accession>
    <name>A0A8J2ED36_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Similar to fs(1)h: Homeotic protein female sterile (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HICCMSTLAB_LOCUS1333</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001116">
        <property type="protein sequence ID" value="CAG5075179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2ED36"/>
    <dbReference type="OrthoDB" id="21449at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050935">
        <property type="entry name" value="Bromo_chromatin_reader"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22880:SF225">
        <property type="entry name" value="BROMODOMAIN-CONTAINING PROTEIN BET-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22880">
        <property type="entry name" value="FALZ-RELATED BROMODOMAIN-CONTAINING PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00297">
        <property type="entry name" value="BROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bromo" evidence="4">
        <location>
            <begin position="55"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="229"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAG5075179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="249" mass="28884" checksum="BA45606E6E891AFC" modified="2022-05-25" version="1" fragment="single">SYVIVKMASSRKVMSNKGMRVCMEVMVELLSKKNEEVVWPFYTRFDAEIMNPESKRPMNLKTVWSKLNAGEYSEVDEFVEDIRFIISSAFKLATITPKKSIWRTWTKEFQRLFDSLHAKKIHDEDLSDPEHPEHHKKSNKIKRKRIVLVYQKFLTASPKPGKSVKAFTGQVSRAHKVKDPKEIKPLNITAKNAIIEFALKVAQDKNWKNKKGVATTREELQHVMTQRLGELKRSAELNKKKNDSTEPSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2EF90</accession>
    <name>A0A8J2EF90_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS342</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001114">
        <property type="protein sequence ID" value="CAG5073399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2EF90"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5073399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="275" mass="31697" checksum="9A12ABAC0A88D860" modified="2022-05-25" version="1">MSLVNLIGRLNLSGNLIYSTNAAGIFLKPHNFNGDPIEFRNEDTDFVKDLTFWNVNADLKLIIGITSDNSQLICWNLESGQIVGADAFDNRHHIFSMNKSFLFLITNHLEITAVKFIIDLEGVFDEVIVQDTIIVNLPRKFNSFGFEIIEISTNAEIVSIVRRRNKIFKVVQLKIIFNDPEDDESFYFSVFNIKRYSLPDVDENTPIKCHVALSKFLLLSFGSILFVHLIEEPNTNQRKKTSRWEYDRIITSIKMFIDVILLGFENGKTFIYLIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2EG55</accession>
    <name>A0A8J2EG55_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to rnaset2: Ribonuclease T2 (Danio rerio)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS933</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the RNase T2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001114">
        <property type="protein sequence ID" value="CAG5074161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2EG55"/>
    <dbReference type="OrthoDB" id="435754at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033897">
        <property type="term" value="F:ribonuclease T2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006401">
        <property type="term" value="P:RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.730.10">
        <property type="entry name" value="Ribonuclease T2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001568">
        <property type="entry name" value="RNase_T2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036430">
        <property type="entry name" value="RNase_T2-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11240">
        <property type="entry name" value="RIBONUCLEASE T2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11240:SF22">
        <property type="entry name" value="RIBONUCLEASE T2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00445">
        <property type="entry name" value="Ribonuclease_T2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55895">
        <property type="entry name" value="Ribonuclease Rh-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU004328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5074161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="154" mass="18188" checksum="FF8D1FDB6BE5CCF3" modified="2022-05-25" version="1">MVMTLNDILEKRGEIREYLELFGSAEENIANIWAEQGKCTTYFKGIDTELKYYKKSLELFDKYNIDAILRQSNITPGKNYTYQEISDAVLKGINGKTPIIQCGHIDEVNIDNPFQRKDRCKRDQLIYYQGTQDYINCDREFEFPRYSVWIIVSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2EHL0</accession>
    <name>A0A8J2EHL0_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Carboxypeptidase Q</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="21">Plasma glutamate carboxypeptidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">HICCMSTLAB_LOCUS1854</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subunit">
        <text evidence="20">Homodimer. The monomeric form is inactive while the homodimer is active.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Golgi apparatus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Lysosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the peptidase M28 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="23">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001116">
        <property type="protein sequence ID" value="CAG5075773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2EHL0"/>
    <dbReference type="OrthoDB" id="10013407at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004180">
        <property type="term" value="F:carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070573">
        <property type="term" value="F:metallodipeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043171">
        <property type="term" value="P:peptide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.30.30:FF:000009">
        <property type="entry name" value="Carboxypeptidase Q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039866">
        <property type="entry name" value="CPQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007484">
        <property type="entry name" value="Peptidase_M28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12053:SF3">
        <property type="entry name" value="CARBOXYPEPTIDASE Q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12053">
        <property type="entry name" value="PROTEASE FAMILY M28 PLASMA GLUTAMATE CARBOXYPEPTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04389">
        <property type="entry name" value="Peptidase_M28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 23" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="13" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="18" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="15" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="19" id="KW-0458">Lysosome</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="9" id="KW-0645">Protease</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0964">Secreted</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <keyword evidence="14" id="KW-0862">Zinc</keyword>
    <keyword evidence="17" id="KW-0865">Zymogen</keyword>
    <feature type="domain" description="Peptidase M28" evidence="22">
        <location>
            <begin position="284"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00014116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00025833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00033328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF04389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="CAG5075773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="431" mass="47687" checksum="F399F5475F21D6E1" modified="2022-05-25" version="1">MKTLTFTYIYIYLFLAIIKINQINCYRVVERLSDSSDSCDGVLSPDLIKEIDSYQPIVDRIVNEATNGSFKGRTWRDLSDFVDDYGSRFTGTQNLEDAIDHVLLRSREFGLENVHGDVVPVPRWIRGNESATMLSPREKNLRMLGLGYSNGTGTSPGGITAEAIVVESFEELKKRASEVPGKIVVYNQKFISYGKTVEYRSRGAIEAAKLGAVATLIRSITPFSIYSPHTGMMSYSESVKKIPAACITVEDAHLLGRLAKRGKKLRINIKMDAHLLKASGRSRNLISEISGSTKPEKVVVVSGHVDSWDVGQGAMDDGGGAFSSWVSVLLLKGLGLQAKRTIRSIMWTAEEMGIIGANYYIKNGPDIENWVNDGVPGASLWNKNERYFWFHHSEGDTMDVEAPDNLDMATALFAATSYIIADINLDLPRNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2EK81</accession>
    <name>A0A8J2EK81_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Similar to Transposon TX1 uncharacterized 82 kDa protein (Xenopus laevis)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HICCMSTLAB_LOCUS1594</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001116">
        <property type="protein sequence ID" value="CAG5075440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2EK81"/>
    <dbReference type="OrthoDB" id="7701518at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="184"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="197"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="210"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG5075440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="417" mass="46534" checksum="A8097DB1F5E11611" modified="2022-05-25" version="1">MVASLNCTQALLTENVPSKEQAIILDSVDGVQIHEYAVALGSKIGPENIRYLSRIANNRVCIYLSTKEVADNLIENHKTVKVRDTDIYIRSLISRNKRLILSNVPPIIPNDVIIEKLKESEINPVSNISTLRAGLNIPGYQHILSFRRQVFIKPEEANNIPTLWKIDFDDTSYYVYSSLDTMLCFNCKEEGHLAKACPINPQSDADKTKMTTTSHSSQENTVTQKPTFPSLPSRTSTLIAPNNTTKPPADINNTSPSTKRPRSDGSSQSSVLTQEQLFAKPKTTEQLRLAKKVKPDSQILSLPTSIEVAMQSTPADFPYSYTQLSNFLEDAPKIKCIEELLAKHKFSAADTVVMLRKLYLHLENRKQKRRFTRIINRIEGNVIDDTSSQSSYGSSGNLMDLEESISDLASTNSQGSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2EKC7</accession>
    <name>A0A8J2EKC7_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Similar to Gastrula zinc finger protein XlCGF17.1 (Xenopus laevis)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HICCMSTLAB_LOCUS1670</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001116">
        <property type="protein sequence ID" value="CAG5075516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2EKC7"/>
    <dbReference type="OrthoDB" id="8922241at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24409:SF295">
        <property type="entry name" value="AZ2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24409">
        <property type="entry name" value="ZINC FINGER PROTEIN 142"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="494"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="522"/>
            <end position="550"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAG5075516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="610" mass="69311" checksum="8B1C4BEC68EA3749" modified="2022-05-25" version="1">MKTCTAKEVMAYKSLSEFSLEDNSLFNHVDTKTNIFQKLEPVEQTFYEPEILIMSTDSKIQLLKINKNNLPSEISEEAHFLPSKTCGKSEITLLPIKQEQKSCGHYEPCENIICDVNVQHYVDQLGSSPMLAVNIDDSEINAKVSKHCKNSRCDALSIEHNRCRRAIIRLNRCDKSNACDICGVVLKTRKSRIHHGNCRRKNEYRHNPVDGAQILREKMRERELQIMEAVRARKNDYSDPITCYNKAIEMLKNNSELIVIPKMMTPSQPPIVNQKDNMNETKTLTINGVSQSFDQLLKNIPNITIKNLHSQQNVPNNKLNSSEKNETLSNYNKVDSTNNVTAGDNKFIITTISQPTVPHSFVINDRILTQLKSNMETNVQNPYIMPVRVLPITNLKSEPSLLHQIQGIPKFCIIADNPTPSGTLIKIPPITNTQSSPSSKSKLSHKPSILLKSRSNNIPIKPKPTNPGFTVINSFQPFKHEIINRRKRIEQKPFKCEYCSKRFLTDWYFRLHIIKHKGGMVLKCSECDLSFSNTEDLNKHVSDGHNADAAEISCRNSDSDVEKEKDDDKCISCEDCGKIFDSDTEIDQHECININDLVSTQTNLLISSEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H343</accession>
    <name>A0A8J2H343_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS483</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001114">
        <property type="protein sequence ID" value="CAG5073540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H343"/>
    <dbReference type="OrthoDB" id="8062658at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035192829" evidence="2">
        <location>
            <begin position="21"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="381"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="487"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="625"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="625"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="637"/>
            <end position="651"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5073540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="651" mass="73287" checksum="927D3B0AAFDCD98F" modified="2022-05-25" version="1">MYQSRCLTILFCWTICQSYSQPFDVKMNSNDTNKTRIFSPRMDYDEWTPLGRGDPLKNDPTFDYVPPVLDRVQYWLDTQTSTEASSKRDILILGVTAKKTSPKISEHYLKFADSPKLTRIQESQDGFRNDFTGSTGAEPPKLVRATKFRTNINVNGNSIDFRNQNRIQSLPASYYPSPYYNEKPKPYTMMMPPPINQKSQLNQFGSLNEEVTVAFRPGHLRIPQKAPLSTSLAFDKSNLIYQSTQTLDPWTGNSESSINTWLTNDKYDDHFDHHAAASSNHQVIMGQNTNIIVDDSQKNEQVVVGKKEVSIEESNMLENKTAPETHVVLPNTSTSDESVTVTVVMPMNYKSNVSEENEPTTTVFMTIPTLSTTITTMSTPIPIQSTRTPWRQSKLPPRVFPRRPGHPEMKHIPNNEMIHQMPLQKLPLTSMQAPTTVDPMRRQVLDNSDIKSPLAAILNQEDLMRMTMTTSTTSATPTAAFTASTRNPFEKSTTADPPTTILSNEQSSNSISFHSKQPIHKPMYLIIQGHSKVKTYKPTVIKHSLPPDNAIASRSKMMTTSRPISKFEQFVNDNTRVAPTMLPRNTENNQEVKAAKEKRVEHDSLLSLVESGLSALTAPPLTTLNSATIDQDNTDSTYDDDDDDDDLLINN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H5D0</accession>
    <name>A0A8J2H5D0_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Similar to Cubn: Cubilin homolog (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HICCMSTLAB_LOCUS421</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001114">
        <property type="protein sequence ID" value="CAG5073478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H5D0"/>
    <dbReference type="OrthoDB" id="10009301at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00041">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000379">
        <property type="entry name" value="Cubilin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000429">
        <property type="entry name" value="Cubilin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.290:FF:000060">
        <property type="entry name" value="Cubilin homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.290">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000859">
        <property type="entry name" value="CUB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053119">
        <property type="entry name" value="Cubilin_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024731">
        <property type="entry name" value="NELL2-like_EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049883">
        <property type="entry name" value="NOTCH1_EGF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035914">
        <property type="entry name" value="Sperma_CUB_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47761">
        <property type="entry name" value="C-TYPE LECTIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47761:SF1">
        <property type="entry name" value="C-TYPE LECTIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00431">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00008">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12947">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07645">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00042">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49854">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01180">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1 5" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="EGF-like" evidence="7">
        <location>
            <begin position="203"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="7">
        <location>
            <begin position="240"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="6">
        <location>
            <begin position="283"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="207"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="228"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="267"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG5073478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="406" mass="42816" checksum="8CA76A29AAC1014C" modified="2022-05-25" version="1" fragment="single">ACPSGWYGVDCTSNTAVCNAQDSHKLCGDHGTCVATGTTRGYTCICDQGWKSNGDDPACKIDVNECEARHPPCSMQPYVPCINVPGDFYCGSCPAGYTGNGHYCADIDECSTDNGGCSIVPKVQCINTMGSRVCGSCPPGYQGDGVTCVFIGTCRINNGGCHPLAICIDNPGFNNLLVECRCPTGYHGSGIGPQGCQPGTEVDQGPCASHPCIHGHCIPHDLSFICRCDPGYTGITCATPINPCSPNPCKNDGICMLTADQQVSCECTAAYSGPRCETPKETCGGVIRDVAGTLTYPPNGVTYGHGLSCAYILATNTSLVLNVTFTQFDLESTPGCRHDFLQIHDGGNAGSHQIGRFCGKNLPMNGNIISTHNSIYLWFHTDSSISRTGFSLHWNSIPPVCGGHLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H5W6</accession>
    <name>A0A8J2H5W6_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Similar to Hr96: Nuclear hormone receptor HR96 (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">HICCMSTLAB_LOCUS2444</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the nuclear hormone receptor family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001117">
        <property type="protein sequence ID" value="CAG5077397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H5W6"/>
    <dbReference type="OrthoDB" id="6352325at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004879">
        <property type="term" value="F:nuclear receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd06966">
        <property type="entry name" value="NR_DBD_CAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06929">
        <property type="entry name" value="NR_LBD_F1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.565.10:FF:000035">
        <property type="entry name" value="Nuclear hormone receptor HR96"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.50.10:FF:000042">
        <property type="entry name" value="Nuclear hormone receptor HR96"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.565.10">
        <property type="entry name" value="Retinoid X Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035500">
        <property type="entry name" value="NHR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000536">
        <property type="entry name" value="Nucl_hrmn_rcpt_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050234">
        <property type="entry name" value="Nuclear_hormone_rcpt_NR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001628">
        <property type="entry name" value="Znf_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24082">
        <property type="entry name" value="NUCLEAR HORMONE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24082:SF283">
        <property type="entry name" value="NUCLEAR HORMONE RECEPTOR HR96"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00104">
        <property type="entry name" value="Hormone_recep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00105">
        <property type="entry name" value="zf-C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00047">
        <property type="entry name" value="STROIDFINGER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00430">
        <property type="entry name" value="HOLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00399">
        <property type="entry name" value="ZnF_C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48508">
        <property type="entry name" value="Nuclear receptor ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51843">
        <property type="entry name" value="NR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00031">
        <property type="entry name" value="NUCLEAR_REC_DBD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51030">
        <property type="entry name" value="NUCLEAR_REC_DBD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8 10 14" id="KW-0675">Receptor</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 10" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4 10" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Nuclear receptor" evidence="12">
        <location>
            <begin position="12"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="NR LBD" evidence="13">
        <location>
            <begin position="471"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="164"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="167"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CAG5077397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="692" mass="78341" checksum="B1C4CEE3222DFF27" modified="2022-05-25" version="1">MEDEQTSGREANKICGVCGDRALGYNFNAVSCESCKAFFRRNALKNKDFRCPFSENCNVTPVTRRFCQKCRLDKCFSIGMRKEYIMTEEDKVLKRQKVEQNRAKKRSSDEIRGPKMKREIIEDANFDDTSMSVASVASTVSETYFWESDKKYTDLDGNRERTIESMSPTTAASVPSPSSPPENRDIIGSKTLDMLKDSSQPSQSFKKCSTHLSTKNPCSSEKLITCNVIESLNNEEYSHLDNCGVSSRLDDNLVLSRDKPESSVIEDCTKNGQKNSSIFAEKLTIKSDFFIKILQDNPQLVAKFLEDKSTVSKMMSEPQVAIMLANDPQVSRLLELDSDESSKLNNLTTSRGSNNIICNLLDSEQQNSDNPILTNLITSHKSSESDNKVDEFNGGNDWSRETDDVTRDVVQDVQRIPIAANSIESILCEAIKLEFSAYSALRGNQNSRELNDAERAKLNELIVANKALLAPLDDDITNLIGEECRFKGTAEYSDPMLLDVINLTAVAIRRLIKMAKKINAFKNMCQEDQLALLKGGCTEMMILRSALNYDSDKNMWKIPHSQEKMSKIKVEVLKEAKGNLYSEHARFVGTFDPRWRDENIILILSAIALFTPDRPRVVHSDVIKLEQNSYYYLLRRYLESIYPGCEAKSTFLKLIQKISELHRLNNEVVDVYLNVNPSSVEPLLIEIFDLNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H6J2</accession>
    <name>A0A8J2H6J2_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Similar to Zcchc2: Zinc finger CCHC domain-containing protein 2 (Mus musculus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HICCMSTLAB_LOCUS2794</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001117">
        <property type="protein sequence ID" value="CAG5078626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H6J2"/>
    <dbReference type="OrthoDB" id="6361509at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058599">
        <property type="entry name" value="PHAT_Smg/ZCCHC2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057327">
        <property type="entry name" value="Vts1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042344">
        <property type="entry name" value="ZCCHC14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16195">
        <property type="entry name" value="ZINC FINGER CCHC DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16195:SF16">
        <property type="entry name" value="ZINC FINGER CCHC DOMAIN-CONTAINING PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26034">
        <property type="entry name" value="PHAT_SMAUG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25479">
        <property type="entry name" value="Vts1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101447">
        <property type="entry name" value="Formin homology 2 domain (FH2 domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="4">
        <location>
            <begin position="1052"/>
            <end position="1067"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="289"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="412"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="558"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="705"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="761"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="975"/>
            <end position="1051"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="800"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="306"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="323"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="336"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="352"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="385"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="416"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="428"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="450"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="710"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="978"/>
            <end position="989"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="1001"/>
            <end position="1014"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAG5078626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="1099" mass="118920" checksum="678421FAC72C11F6" modified="2022-05-25" version="1">MVCKENVVSWFGNLSSYKRIDIMCTLLNMCLPFEVRYLGTCIEDRGKRDYNDLRDTEHHANNVADLAELAKSGGVTDTRIRRKLVLYVALLHGCNYDCATAFYKSLANIDTQELANLLGAAGQDEQSLEELILLYTMALNHPAFTYEQKAIFGNIFLKLQEEEESRIINNNIKHQPVNVQGMELQTGNCIMPPPIQHYGGDMQFRNPMVSGIPPGLSMPPPPPGLCLPPDQMMNPQNHTPGQYLHLGFPTINSMPWTGQTPMMIGSNHHHHHHHQMMYHTVTPGDMIVYPASPLVSRPSSPIQHPLQPPPPPPPPPPPPSRSPPSRSNSPNRRSMRTWSSAEERSSGNINQTNTTSCSSNSSSSCSSSSSSSSSSNNSSTTVSTAGRNINVNPNQTSVPRSVVVVVTSGTLQSTTPTSGIYSRHNSLTGGGGGGGGGGGGGISTTCTGVKNPPKLKSPSSSISGSTGGSATVNNDTLRETLGKEMPNYKACLQNYSMEEIRRISDEELREIGLTPNAVGQLRSIVRSQSSNSTNGAQSNQIIADQKNNKVESFSLTTDQTADEVTQQQQQQQTRQQQGQISNEFYNSKLPGGLPFFQDFHQSIHHHHHHHHHHHSHLANITSIRRYQTMQPGPPPPPPTMDPNQQLSLFHSAPPSIYATQNPCYACLTVPAAAAATSTVQNRYPSRCNAQHMYCVAQLQALRLDADSSRHGSQSSSSDSSTGSRSPPGTPPAVPWPGNSTFIANSTVINENISLSTTTTTTTTTTVSASSNSSEQSPSSSSSVLSYSTVAVSRQNTSTSIQSQQQQQQQQQQQQQQQQQQQQQQQQQQQQQINNDRTRSMKKNQTMRQKNQIINGVTNNSNACSVSTGAIPPASSVNLSTPAPSPQQHCGISGISGISGISGISGIPGMSGISGMTGMSGGFPTGNHHPQMTFLPHGNHFPGTTPRLPLNSTNIYSSGYSHTIYSRPTVSMAPAGFQPTVSPQGFQSNGEIIYQYPGQPAGTPPPPPPPLPPPGIVTGLMPGLPIGHHQSQQSHHSHHDHGQQQPHQPKISCYNCGSNNHLAIDCKEQTMEDLTKRAQYRLDFKMPKPTNPECPSVSDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H7F9</accession>
    <name>A0A8J2H7F9_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex</fullName>
            <ecNumber evidence="3">2.3.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HICCMSTLAB_LOCUS3023</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>(R)-lipoate</name>
            <dbReference type="ChEBI" id="CHEBI:83088"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the 2-oxoacid dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="3"/>
    <dbReference type="EMBL" id="CAJNRD030001117">
        <property type="protein sequence ID" value="CAG5079484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H7F9"/>
    <dbReference type="OrthoDB" id="537444at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045254">
        <property type="term" value="C:pyruvate dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006086">
        <property type="term" value="P:pyruvate decarboxylation to acetyl-CoA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06849">
        <property type="entry name" value="lipoyl_domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.100:FF:000010">
        <property type="entry name" value="Acetyltransferase component of pyruvate dehydrogenase complex"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.320.10">
        <property type="entry name" value="E3-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001078">
        <property type="entry name" value="2-oxoacid_DH_actylTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045257">
        <property type="entry name" value="E2/Pdx1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036625">
        <property type="entry name" value="E3-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004167">
        <property type="entry name" value="PSBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23151">
        <property type="entry name" value="DIHYDROLIPOAMIDE ACETYL/SUCCINYL-TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23151:SF90">
        <property type="entry name" value="DIHYDROLIPOYLLYSINE-RESIDUE ACETYLTRANSFERASE COMPONENT OF PYRUVATE DEHYDROGENASE COMPLEX, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00198">
        <property type="entry name" value="2-oxoacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47005">
        <property type="entry name" value="Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="Single hybrid motif"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51826">
        <property type="entry name" value="PSBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2 3" id="KW-0450">Lipoyl</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Lipoyl-binding" evidence="5">
        <location>
            <begin position="42"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="Lipoyl-binding" evidence="5">
        <location>
            <begin position="164"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="domain" description="Peripheral subunit-binding (PSBD)" evidence="6">
        <location>
            <begin position="283"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="125"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="257"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="335"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="136"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="257"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="338"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAG5079484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="583" mass="62626" checksum="923CAEA4A2F60D78" modified="2022-05-25" version="1">MIRTTVGFISSKYSYNLVSRFVLPVKYNQLCLHTSRLLNVKGKEITMPSLSPTMESGTIVKWLKKEGDPIQPGDAIADIQTDKAVMTFETEEESIMAKIIAAEGTKDIKVGTVIALTVEPDEDWKSVEMPDASRQPAASSASVSAPASAPSSSSNEVVEPPPGQTNVAMPALSPTMTSGTIVKWLKNEGDEISPGDAVAEIQTDKAVMTFEMEDDAILAKYLVKEGSQVDVGQLIAITVEKGMDWKSAVIPTSTKAVAKESSTAAPPKATPSQSGQPAPSDQVYGLAVKRLLEEYAISSGSVKGSGRPNRLLKSDVLAHIESNKIQKVFLKADEPSATGKQAPTTKTQISAPLKSGPSTYTDHEVSNIRAVIAKRLGESKSSIPHSYITIDVNIDKLNELRSELKAENLKVSMNDFVIQAVAQSLIQCPPINSIYKNEQVTRIPNVDVSIAVSTPTGLITPIIFDTVKKSLTDISNDVKSLADKARKGTLKPNEFQGGTFTISNLGMFGIKEFSAIINPPQTAILAVGTGRDVLDTSLRKKSMMSATLSYDSRAISEDQAANFLSVLRSRLENPSFRSIGSNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H9S4</accession>
    <name>A0A8J2H9S4_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HICCMSTLAB_LOCUS5038</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5088954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H9S4"/>
    <dbReference type="OrthoDB" id="20960at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052470">
        <property type="entry name" value="ER_Stress-Reg_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46542">
        <property type="entry name" value="X-BOX BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46542:SF1">
        <property type="entry name" value="X-BOX BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="1" id="KW-0832">Ubl conjugation</keyword>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="65"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAG5088954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="380" mass="41785" checksum="18583AF08F2DE2D2" modified="2022-05-25" version="1">MISPKSVIITLPKGLQKSPVISPVRNIIKPTGNLNFTTSILATKSKVDAKNMQKIQHDCYGDIQGELMKTEIDRKKAKLDELEETVRTLVEKNELIAEECDSLRAQNEALLAENQRLKEGDKSVNKTDSDRYCSMCMGRVGCVAPALGSAVSPINPLPQGGATQLAPSLTPSANIDALPPLEELFADIQSDGYVERLEELAESLLREVTSGVEAHAQRPNEQVTIKKDTFEESDDPKKMVGPASKNVEASPICSSLNLYPKESNPFPAQYVDKSSISELFKREVKIKQEPISDVDTVYGTYDEATNCITIIYPGEDEGIRIDECVQEVGSDESANLTPNYYNNVSPAYSIADSMSPSSMHSDDSDANSIRFPSIEYKIKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H9X2</accession>
    <name>A0A8J2H9X2_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Similar to BTAF1: TATA-binding protein-associated factor 172 (Homo sapiens)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HICCMSTLAB_LOCUS4862</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5088475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10252227at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017025">
        <property type="term" value="F:TBP-class protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17999">
        <property type="entry name" value="DEXHc_Mot1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10810:FF:000042">
        <property type="entry name" value="SNF2 family helicase-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044972">
        <property type="entry name" value="Mot1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044078">
        <property type="entry name" value="Mot1_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022707">
        <property type="entry name" value="Mot1_central_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36498">
        <property type="entry name" value="TATA-BINDING PROTEIN-ASSOCIATED FACTOR 172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36498:SF1">
        <property type="entry name" value="TATA-BINDING PROTEIN-ASSOCIATED FACTOR 172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12054">
        <property type="entry name" value="DUF3535"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="10">
        <location>
            <begin position="1354"/>
            <end position="1518"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="11">
        <location>
            <begin position="1705"/>
            <end position="1860"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="239"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="691"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1055"/>
            <end position="1074"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="692"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="1057"/>
            <end position="1068"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAG5088475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="1860" mass="206199" checksum="5DAC4F969F5E7D86" modified="2022-05-25" version="1">MAFLSNGKWQCGLAECLNVYFELITTLKANKRYSCSRLDRLFILLETGTNSATKKAAAQQLGEVQRLHPHELHHLLARVSGLLKSPQWDTRVSAALAIQAILSQVPVWDPQPIKSESKSLNENRSQRNENIKNQLTFESFDMNQVLAKSTHLTGSEGSEYDLIIADGDQQQSFGSQGEKLLAANLGLDPRLIGVDTSELFTAEDLALPVKSCLTQAQSNKISVSETLEQSGGLSRREINRAKRKARQSISKQRSREPEEQLETTNNVIQPNDNVESLKKKIKVEDVVSTDVANYEPKKDETNVSAVPDGTGCWPDTTLDWPLEAFSESLCQDLFSQKWEIRHGAATALRELVRLHGKGAGKSRDQSQEEMEESNRRWIIDAALRLLCVLGLDRFGDFVSDQVVAPVRETCAQVLGSLVLLLPNDGGKSIMGIVKVLLKLLEHDEWEARHGSLLALKYLLAVRDDLLDQILPTSFPAVIRGLSDPVDDVGAAAASALIPVASTLPRLLKPDQLQAVIARLWELLRDQDDLAAACNSFMGLLAAILSLPTARACLSPQPLSQVLPRLWPFLSHASSSVRKATLQTLQTLTEEDKSNEENRKERWGEESSIILQEALRHVFQRVLIEHVTAIQEVAEKVWENLVTYSDLELLLHAACPCVSTWLCLAMQPDNVPFNSGLLINYSNINVVNSSPSKGTSKSGQINGDGQSDSGCSSISVTGKSTSELKVYIGGIETVPQSIRLSNSVRARIMATRMLGLLSRYVVKPAPGVIYTPDIPSPALCYARVLLAHLASRSALQRTVVGLTIAHWAALEHPNTPEIPESLRDKLLGCLNECTYYDEIAGAFTRLLHDSKDYIATLKHYKLILPIDTDNTNGVLNLDQIASLAAKPIIGLQALNSRTSTGVGSGAALNKLKPKLVTSLEERRKTLEVGASSTAAQQLSLNVMAMAALSGGATMLHCLPEPPQPLNPLVKPLMEAIKREEDEDLQKLAAKHLAHLVDLCTNRTPSPNNKITTNLCTFLCSDVEFTPRVTDRESDPFDGILTLNNRHKHAERIAYNRGTGIGGSSSGRGPGRPPATEIPLEELLAYEEPEAKAARNRRRGATYALTAIVKLIGSELPIRLPHLWEMIIMKNHNKIDLSLQSKVEQVNNLIFTLQVIEIVVPSLDKSLLPPVLECLPRLCSLLAHPYKVVRHMVSRCIATFAVLNTEITMGQVVRSVIPLLETHSADTSVPKGLSTPVESDLRRQGAAEALTCIVENLGVNVVPFAVLFMVPLLGRMSDQNQSVRLVCNATFATLIQLLPLDSGSIADPPHLVEEKTQERKFFEQLLNPRTIPETKLTVKVAAELRSYQQQGLNWLDFLNRYRLHGVLCDDMGLGKTLQTLCILALDHDRNKDAPPSLVICPPTLTGHWVWEAEKFLQSKDLPVLQYSGSPPDREKLRPHVHQYRLIVASYDIVRKDLEFFEAIQWNYCVLDEGHIIKNGKTKNAKAAKRLRSYHRLILSGTPVQNDVLELWSLFDFLMPGFLGSEKQFAAKYSRPILACRESKAGPKEQEAGALAMEALHRQVLPFLLRRNKEDVLKDLPPKITQDYYCELSVLQKRLYEDFRTRHSATLMSNSTLPSTASSTPRGHVFEALRYLKNVCNHPKLVLGPNHPLYHEIKLQLEQQQTNLSDIDHSAKLPALKQLLLDCGIGQTQQQKPSTPSGLIDSQQTTQQLVSQHRALIFCQLKAMMDIVEKDLLSIHLPTVTYLRLDGSIPAIRRHAIVSKFNADPSIDVLLLTTQVGGLGLNLTGADTVIFVEHDWNPMKDLQAMDRAHRIGENSRSISSIPGVSRSVLDIIPELWEQQQYDDEYDLDAFLSTLKGSNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H9Y5</accession>
    <name>A0A8J2H9Y5_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to hH3v: Histone H3-like centromeric protein hH3v (Neurospora crassa (Strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987))</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS5319</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the histone H3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5089656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H9Y5"/>
    <dbReference type="OrthoDB" id="420022at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000164">
        <property type="entry name" value="Histone_H3/CENP-A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11426">
        <property type="entry name" value="HISTONE H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00622">
        <property type="entry name" value="HISTONEH3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00428">
        <property type="entry name" value="H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00959">
        <property type="entry name" value="HISTONE_H3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5089656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="105" mass="12185" checksum="0400733712094CEC" modified="2022-05-25" version="1">MVRRKSSPTRSRPASGSKGGQKTGRANVAGRNNRVKSGVIALQEIRFLRKTTKLIIPKLPFSRLVREIMHELFPRSEIFSKRITLMQRDMILMRRLRGRDDVINR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HA80</accession>
    <name>A0A8J2HA80_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS4939</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5088679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HA80"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5088679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="99" mass="11382" checksum="62C9704BFB16D034" modified="2022-05-25" version="1">MITVTAINVRSDVTVAGSTDCSIDSAFLCLWPTCACTKKIKILYQLSSFRPHRSPRRPRRLKTRKISREVRIVTIELALGLPRIRLDLKPEFLRIVLFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HAE3</accession>
    <name>A0A8J2HAE3_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">N-acetylgalactosaminide beta-1,3-galactosyltransferase</fullName>
            <ecNumber evidence="4">2.4.1.122</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">HICCMSTLAB_LOCUS5060</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyltransferase 31 family. Beta3-Gal-T subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.122" evidence="4"/>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5088999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HAE3"/>
    <dbReference type="OrthoDB" id="421979at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016263">
        <property type="term" value="F:glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.50">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026050">
        <property type="entry name" value="C1GALT1/C1GALT1_chp1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003378">
        <property type="entry name" value="Fringe-like_glycosylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23033">
        <property type="entry name" value="BETA1,3-GALACTOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23033:SF14">
        <property type="entry name" value="GLYCOPROTEIN-N-ACETYLGALACTOSAMINE 3-BETA-GALACTOSYLTRANSFERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02434">
        <property type="entry name" value="Fringe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="16"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="domain" description="Fringe-like glycosyltransferase" evidence="13">
        <location>
            <begin position="200"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CAG5088999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="377" mass="43536" checksum="8B552D9CA3A7931E" modified="2022-05-25" version="1">MNYVPVVIIIVKNTNCFFYMTFEMFIIALCLFIFISPSSSSLKQIDGSWTFFPLIPKLSSKFPQAKWFFFCLENTDIKLPVLLTILSKFKVSENTWISHVLYDEEPTIIHHFADHTKKFKYPNLASGFAMTSTLLHNLDKRLSKEGLPNVDFSIDASYEFSSYIYNNGKGPRLTHSPELCIFFTENCATYPKGFHACTNSISQDDIYVAVKTYDKNHQDRVPIIMKTWLKNVKNFGLYSNVEDKSLPNVHVVPDTKEGHCKKTYAILKHANYVLKKNNFNWLVVADDDTIFSIARLLRVLTCYNPKKLIALGERYGYRTIRDTGYDYLTGGAGLVLSLSLEPVSFHKFWMIDPLEVYDQWFSDADSTLESKWKHTEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HBD5</accession>
    <name>A0A8J2HBD5_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS4995</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5088823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HBD5"/>
    <dbReference type="OrthoDB" id="7667736at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="63"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5088823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="111" mass="12352" checksum="013230F90AAA3E5F" modified="2022-05-25" version="1">MVLVADRRKEGLDVDKHNMHAAIDKYRLAVRQAISNHQIGHNSSFFEDKIINNAPIETTGPFAGYTALHIACMDGDEELIRLLVEDYHANVNAVADDGTQPIQLVPTLMLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HBG5</accession>
    <name>A0A8J2HBG5_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS4226</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5084904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HBG5"/>
    <dbReference type="OrthoDB" id="7610447at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24664">
        <property type="entry name" value="Monjiviricetes_fusion"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5084904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="159" mass="18043" checksum="AD328D5432F74502" modified="2022-05-25" version="1">MAITQWESAYAIIGYDCRSKILNMTTISLVDIDDCELGEEKAEMFLPEIALLQLNEYEHTKIIQCKVEVNRVIQHCGWQSYNSIVNQGINEYIFPISREMCQVAHDHGTFRIGNTVFDGLMPNGETPDSKTQEVYPLLPRINTSTGPPTEIATTQRVFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HBG9</accession>
    <name>A0A8J2HBG9_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Similar to His1: Histone H1 (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HICCMSTLAB_LOCUS6476</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Histones H1 are necessary for the condensation of nucleosome chains into higher-order structures.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the histone H1/H5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5092957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HBG9"/>
    <dbReference type="OrthoDB" id="10070184at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031492">
        <property type="term" value="F:nucleosomal DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030261">
        <property type="term" value="P:chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045910">
        <property type="term" value="P:negative regulation of DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006334">
        <property type="term" value="P:nucleosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00073">
        <property type="entry name" value="H15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000140">
        <property type="entry name" value="Histone H1.0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005819">
        <property type="entry name" value="H1/H5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005818">
        <property type="entry name" value="Histone_H1/H5_H15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11467:SF20">
        <property type="entry name" value="H15 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11467">
        <property type="entry name" value="HISTONE H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00538">
        <property type="entry name" value="Linker_histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00624">
        <property type="entry name" value="HISTONEH5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00526">
        <property type="entry name" value="H15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51504">
        <property type="entry name" value="H15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0158">Chromosome</keyword>
    <keyword evidence="5 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="H15" evidence="9">
        <location>
            <begin position="36"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="96"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="9"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="107"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="153"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAG5092957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="207" mass="21467" checksum="8708992CEA5F2CC5" modified="2022-05-25" version="1">MTDTEVAPAEEKIVAKTDSPKKAKEVKAKKPAAKATHPSTSDMVTAAIKHLADRHGSSLQAIKKYIASTYKVDVEKQAQFIKKFLKSAVTKGTLVQTKGKGASGSFKLATSKAAAKPKPKAASGEKKVASKKAAVKKPASPKKTPGEPKSPVKKAAGAKKAAVKKPASSKKPAAKAPAKPKASASPKAKKATKAPTAKPKSPKPKKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HBN9</accession>
    <name>A0A8J2HBN9_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS6645</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5093174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HBN9"/>
    <dbReference type="OrthoDB" id="7700450at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="116"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5093174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="235" mass="26386" checksum="95A808EC197AEE90" modified="2022-05-25" version="1" fragment="single">MTSELFAIVKWLNDEDKGTYTVGVPTQWIIQFDYQEYCMNSCDADESYVVEWRQGKKPAGGWLCYDAVVTDVSKSIAALEKKFKNNYKCIKSPRLGGCSGNQKSFMDGSAAGSTSNFTNATSITTDKNANKKTSLKRPHSNKDDDNDIERTPLNNSSPVRPRNLFGSNNGENDIVIQLLTEMRNMQENMRNIRPIPRAAEISELLTSKVDYLEKECKNTKITIAGLDFSTNDHIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HBX7</accession>
    <name>A0A8J2HBX7_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS6375</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5092797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HBX7"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5092797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="62" mass="6781" checksum="2971B52F9AC3029C" modified="2022-05-25" version="1">MRDIRIEMESSNRAHKQPTAAVLTASEALPADQINPGIRILSKKSVMNSVGSLINFNVSLRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HC32</accession>
    <name>A0A8J2HC32_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS6403</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5092853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HC32"/>
    <dbReference type="OrthoDB" id="2157380at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5092853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="185" mass="21131" checksum="4B924BCDAFCF3B03" modified="2022-05-25" version="1">MNLPLSMVNVDSMAPSPEYSDSLNTAAPLDLDRFYDLCNCETKIRSTKNVSIDPSPRYFGEHDKMTGEKSPILTSMTSPRGFDGKIISDKYIDEPLIDHKSCSRRMKDLTLSENSCFNQIQDVKGNYVRRIASSDSIPYALSKRENYTRDYQTIDETCCVRRVNSPDVRQLRYIQSAKGAWSYNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HCG7</accession>
    <name>A0A8J2HCG7_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Similar to SLC25A38: Mitochondrial glycine transporter (Homo sapiens)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HICCMSTLAB_LOCUS6974</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>glycine(in) = glycine(out)</text>
            <dbReference type="Rhea" id="RHEA:70715"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5093639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HCG7"/>
    <dbReference type="OrthoDB" id="1924968at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015187">
        <property type="term" value="F:glycine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904983">
        <property type="term" value="P:glycine import into mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03064">
        <property type="entry name" value="SLC25A38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030847">
        <property type="entry name" value="Hem25/SLC25A38"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46181">
        <property type="entry name" value="MITOCHONDRIAL GLYCINE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46181:SF3">
        <property type="entry name" value="MITOCHONDRIAL GLYCINE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 11 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="11">
        <location>
            <begin position="19"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="11">
        <location>
            <begin position="115"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="11">
        <location>
            <begin position="206"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00034060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAG5093639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="287" mass="32459" checksum="945C38D706AD19BD" modified="2022-05-25" version="1" fragment="single">MEGQLADLRSEETTMHKDYPILKSFLAGSFSGTFSTILFQPLDLIKTRLQNTVNHHVSSPKYPMITTVIHIIKKDNIFGLWKGMTPSITRVIPGVGLYFSTLHWLKHTICLEEPLTPLQAVSLGITARSLSGSLLIPITVIKTRYESGVYKYGSMREALRLIYKYEGIKGLSSGLAPTLLRDAPYSGLYLMFYTQLKQLSIKKLNSDVTTHFACGIVAGILASAITQPVDVIKTKMQLYPDKFNNTKSVFIFVYNKYGYRGFFKGMIPRMLRRTLMTTMAWTVYEQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HCQ2</accession>
    <name>A0A8J2HCQ2_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HICCMSTLAB_LOCUS6953</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5093617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HCQ2"/>
    <dbReference type="OrthoDB" id="6380161at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055470">
        <property type="entry name" value="DUF7042"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055471">
        <property type="entry name" value="DUF7043"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055472">
        <property type="entry name" value="DUF7044"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055473">
        <property type="entry name" value="DUF7045"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22255:SF4">
        <property type="entry name" value="CATION-INDEPENDENT MANNOSE-6-PHOSPHATE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22255">
        <property type="entry name" value="LP06548P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23069">
        <property type="entry name" value="DUF7042"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23070">
        <property type="entry name" value="DUF7043"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23071">
        <property type="entry name" value="DUF7044"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23073">
        <property type="entry name" value="DUF7045"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7044" evidence="3">
        <location>
            <begin position="28"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7042" evidence="1">
        <location>
            <begin position="152"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7043" evidence="2">
        <location>
            <begin position="316"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7045" evidence="4">
        <location>
            <begin position="432"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF23069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF23073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAG5093617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="622" mass="70590" checksum="C19F5CF09E250B0D" modified="2022-05-25" version="1" fragment="single">GSVIVSDVSENPSAVVTLPSYDPQFMAHCYFPAEFQGDFLMQVNGPGGKGSANSVEPIQYSALNITFDSIPVWGYCHKRVGENVLLVDTTAEGQCIRCFRLKRRSRNIIEVFSEDLNRCYTYEDIAIASCDKLTSRSVLYRTKEIGGLPIRNEFCPIAGKYSFKYNVNDGTEDTTECNTFSSTLDNCPDGSVFRLQFKKCAFENHGTNLIVENRTTEVDRNITFNCLGSWPAGPDYSNNTRFIALLDTRDGDDFRPRYRCGLYHSDSSTSRIYMAFSSDSSCTQNLHNSTSGYETLILTRALNLQKMPDYVSSHLASYPKWVHGDWEESVISKSTMSFNDLNGYRSYTFVTVDSDDDTDRYIVYSKDHCENQAYVCMMMRQRSENVMEFKIGTISSPVYAKSLCEDPTLDRYDSTSPWMTQARLERIVESPCPITGHYIGRIPDLPGTCAELSSNCNTKEIMYYKVTDCESGELYEERTYLCLGQWEERGVMYTYTKRNDTTNDVYAPTECFVGLIVNDDEIYIKEAGDHCLRNIDPRTEGMRLYRKGQCYGNSPSPAPTPLKPNPHDPIMRITTHSMPGNALAPTKKTPKLISASASLTQHSLNIFIYITIYIFYFEFTHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HCR4</accession>
    <name>A0A8J2HCR4_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Similar to slo: Calcium-activated potassium channel slowpoke (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HICCMSTLAB_LOCUS5630</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5090439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HCR4"/>
    <dbReference type="OrthoDB" id="10035564at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045211">
        <property type="term" value="C:postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060072">
        <property type="term" value="F:large conductance calcium-activated potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047871">
        <property type="entry name" value="K_chnl_Slo-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048735">
        <property type="entry name" value="Slowpoke-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10027">
        <property type="entry name" value="CALCIUM-ACTIVATED POTASSIUM CHANNEL ALPHA CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10027:SF33">
        <property type="entry name" value="CALCIUM-ACTIVATED POTASSIUM CHANNEL SUBUNIT ALPHA-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21014">
        <property type="entry name" value="Slowpoke_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10 12" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0630">Potassium</keyword>
    <keyword evidence="5" id="KW-0631">Potassium channel</keyword>
    <keyword evidence="3" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Ca2+-activated K+ channel Slowpoke-like C-terminal" evidence="11">
        <location>
            <begin position="56"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF21014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAG5090439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="196" mass="21404" checksum="50E65605C0EE9350" modified="2022-05-25" version="1" fragment="single">MITELVNDSNVQFLDQDDDDDPDTELYLTQPFACGTAFAVSVLDSLMSTTYFNQNALTLIRSLITGGATPELELILAEGAGLRGGYSTTDSLANRDRCRVGQISLYDGPLAQYGEGGKYGDLFVAALKSYGMLCIGLYRFRDTSSSADASSKRYVITNPPDDFTLLPTDQVFVLMQFDPGLEYRPNRGTRGKDDAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HCW6</accession>
    <name>A0A8J2HCW6_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Similar to NF1: Neurofibromin (Homo sapiens)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HICCMSTLAB_LOCUS7073</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5093747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="28245at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13313">
        <property type="entry name" value="PH_NF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05130">
        <property type="entry name" value="RasGAP_Neurofibromin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.506.10:FF:000014">
        <property type="entry name" value="Neurofibromin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.506.10:FF:000015">
        <property type="entry name" value="Neurofibromin isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.506.10">
        <property type="entry name" value="GTPase Activation - p120gap, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029473">
        <property type="entry name" value="MOR2-PAG1_mid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054071">
        <property type="entry name" value="PH_NF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039360">
        <property type="entry name" value="Ras_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001936">
        <property type="entry name" value="RasGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10194:SF142">
        <property type="entry name" value="NEUROFIBROMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10194">
        <property type="entry name" value="RAS GTPASE-ACTIVATING PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13716">
        <property type="entry name" value="CRAL_TRIO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14228">
        <property type="entry name" value="MOR2-PAG1_mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21877">
        <property type="entry name" value="PH_NF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00616">
        <property type="entry name" value="RasGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00323">
        <property type="entry name" value="RasGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00516">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50018">
        <property type="entry name" value="RAS_GTPASE_ACTIV_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ras-GAP" evidence="4">
        <location>
            <begin position="1228"/>
            <end position="1423"/>
        </location>
    </feature>
    <feature type="domain" description="CRAL-TRIO" evidence="5">
        <location>
            <begin position="1558"/>
            <end position="1716"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="781"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="2513"/>
            <end position="2537"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="2713"/>
            <end position="2755"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="2518"/>
            <end position="2528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="2740"/>
            <end position="2755"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAG5093747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="2755" mass="312049" checksum="280414A287C0C345" modified="2022-05-25" version="1">MGTQKPEEWANLLITRFENELPCRAGSQTTNSRINEQENRKFLIQISRHRFSLVISGLTKILQRVNDTLPGTGGGQRSFHNTDQERNCYESIIIVLDTLEQCLANQPKDTSNKDETMNVKLLLRPICQFINISNDSPQHVHIKNLASKVLFALSLNFFTAVFNRISDHLQELTVCNEENPDCSDIELIQHINIDVDRLIQILNETVQKYKLLKKSAHTVLVNSLERAIWNWMDTYPHEFAEVQKKLDYSDTSKEIQKKSNDALAKVCGELFDVLDTYAENKKSRNIAGWPLQIMLLILSPKVLEEILNAKTTAPCSPKHSRKKQFIDGIKRSLGMHGGSSSKSLTEAAIVTCVKLCKASTYINNLDSSNVIFTLVRQVINDLTAQLFNITKPFSRGQNYIAQDIDMMIDCFVSCFRNRLHNDEITKVCLNLNAPSTWQFVLVSSLYRIATPPKLSWWPEINLVYQRSAELRNLFTDTLNKVTQSYISHTTLRMIPSFSMKGKEQGKYKDRGEDIASHRNLLLWMVRLIHTDPMLMLYNPGKAGHEIQSSTLELINGLVSLVHQPTMPDIANEAMEALLVLHHPDKIKSWNPEAPIKTFWDISSRALFSISQKLIQHQIVNYTDILKWLREILVRRNAFLSQNKDYANVGSQIAICKQAHIKLEVVFFMYLWSVDMEAVLVALSCFSLLCEEADIRCGSDEVAVTCLLPNYHLYIELAQTSTALTTASGESKMCYYEHNQGRAALQKRIMALLRKIEHCVNGVQPAWEETFRNWESTSRQLTNYPKNKTEDGQVESFHRSTGKRRASHQNSEHELEEQINEWANMTGFLCALGGVCLQRKSPSRPMSSGMLPNPEPKKSSTKQIEAACLANPTQEVQYCPVTQFVFNLLRLLICNNEKFGAQIQKHVKELVGQEMSAALYPILFDQIKSIVEKFFDQQGQVIVLDVNTQFIEHTIFIMKNVLESKSDQPSEYLGMTSIEGMTLAIVRYVRHLDTAVYTIHIKTKLCQLVEAMMKRRDDLAFRQEMKFRNKLVEYLTDWIMDTTHQIAPQPSTGDLTTITRDLEQACMEAVGSLLRGLPLQPEESDRGDLMEAKSQLFLKYFSLFMNSLNDCNDAANEDKDVVSTTRMTSVKLSSLRNATIQAMSNLLSANIDSGLMHSIDLGYNRDLQTRAAFMEVLTKILQQGTEFDTLAETVLADRFEQLVQLVTMISDKGELPIAMALANVITSNQMDELARVFVTLFDAKHLLSPLLWNMFYREVEVSDCMQTLFRGNSLGSKIMAFCFKIYGASYLQNLLEPLITPLLDDPSTSFEVDSARIDSNENIEQNGRNLIALTKKVFDAIVSSADKFPPQLRSMCHCLYQVLSKRFPQCPQNNIGAVGTVIFLRFINPAIVSPQEMSIVNKPVPMQIKRGLMLMSKILQNIANHVEFSKEQHMLPFNDFLRARFEIGRRFFIQIASDCETVDQTNPPMSFVSDANVLALHRLLWNHQERIGDYLSSSRDHKAVGRRPFDKMATLLAYLGPPEHKPVESHLLFSYSRWSSIDMSATNFEEIMVKHNMHEKEEFKSIKSLNIFYQAGTSKQGNPVFYYIARRYKIGETNGDLLIYHVILTLKPFCHSPFELVIDFTHTCSDNRFRTEFLQKWFLVLPKVAYTNIHAAYIYNCNNWVREYTKFHDRILAPLKGNRKVIFIDLPARLNDLIDPEQQKLPGATLTLDEDLKVFPSALKLSHKDTKVSIKVGPSAIQITSAEKCKVLSHSVLLNDVYYASEIEEVCLVDDNQFTLTISNEAGPLSFIHNDCDSIVQSIMHIRNRWELSQPDSMSVHPKIRPKDVPGTLLNMALLNLGSSDPDLRTAAYNLLCALTATFDLKIEGQLLETSGLCIPSNNTIFIKHLSETLAANDPHLTLEFLEECMQGFKVSTIELKHLCLEYMTPWLKNLVRFYKPNDEGGKRQKQVTQILEKLITLTIEENEMYPSIQAKIWSTIGRLPELIDTVLDHFIQKSVGYGLGSPMVEIMADTAVALASGNVQLVAKKVIGRLCRVVDKTCTSPTPLLEQHMMWDDIAILARYLLMLSFNNCLDVGKHLPYLFHTVTFLVCSGSLSMRASTHGLVINIIHSLCTCSSPSFSEDTYRVLRMSLDEFSLPKFYLLFGISKVKSAAVTAFRSSYRHSNEKWFTNERTLCNTQDRERLSLTSLEVITDALLEIMEACMRDIPRCDWLKTWTSLAKSFAFCFNPALQPRALIVFGCISKSITDQDIKQLLRILVKALESFNDITLLEAIVMCLTRLQPLLRPESAIHRYLFWVATSILQLDEAPLYASGLALLEQNLHTLDSQGTFDDKTLEKVMMSTREPLEWHFKQLDNAVGLSFKSNFHFALVGHLLKGYRHPTPTTVSRTSRVLTMLLAIVAKPFRRDKFEMTPESVAYLAALVSVSEEVRSRCHVRHSLGRNISESSSTDFIDVLVANGPDAAVSTNLTVNLSNRKQKSWDLLDQTAITQARQQKQPLQSGRILFKTQRSFSVPTTKEPKPAEESGSKNRSTRVSVSNENNVLLDPEVLTDFSTQTLVLTILATLVKYSTEDSETRILYEYLAEASVVFPKVFPVIKNLLDAKITSVLFTCHDQAIVSAVQAIIQNMIACEDTGQQLHYLQSCGFGGLWRFAGPFAKCNRTADSAELFVNCLEAMVETCLPTEEAEAPINNEVENDKKAEGITTGKCMVKARLPSQDSNTRDASLLLSSKESSIESRGESSLNTNTSSSSTSQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HDU0</accession>
    <name>A0A8J2HDU0_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">FACT complex subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">HICCMSTLAB_LOCUS5783</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Component of the FACT complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Chromosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the peptidase M24 family. SPT16 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5090888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HDU0"/>
    <dbReference type="OrthoDB" id="10251642at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035101">
        <property type="term" value="C:FACT complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031491">
        <property type="term" value="F:nucleosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032786">
        <property type="term" value="P:positive regulation of DNA-templated transcription, elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01091">
        <property type="entry name" value="CDC68-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.150:FF:000003">
        <property type="entry name" value="FACT complex subunit SPT16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.210:FF:000001">
        <property type="entry name" value="FACT complex subunit spt16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000017">
        <property type="entry name" value="FACT complex subunit SPT16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.230.10:FF:000005">
        <property type="entry name" value="FACT complex subunit spt16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.210">
        <property type="entry name" value="FACT complex subunit Spt16p/Cdc68p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029148">
        <property type="entry name" value="FACT-SPT16_Nlobe"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056595">
        <property type="entry name" value="Fact-SPT16_PH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048969">
        <property type="entry name" value="FACT_SPT16_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013953">
        <property type="entry name" value="FACT_SPT16_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013719">
        <property type="entry name" value="RTT106/SPT16-like_middle_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040258">
        <property type="entry name" value="Spt16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033825">
        <property type="entry name" value="Spt16_M24"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13980">
        <property type="entry name" value="CDC68 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13980:SF15">
        <property type="entry name" value="FACT COMPLEX SUBUNIT SPT16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14826">
        <property type="entry name" value="FACT-Spt16_Nlob"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24824">
        <property type="entry name" value="PH_SPT16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08512">
        <property type="entry name" value="Rttp106-like_middle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08644">
        <property type="entry name" value="SPT16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21091">
        <property type="entry name" value="SPT16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01285">
        <property type="entry name" value="FACT-Spt16_Nlob"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01287">
        <property type="entry name" value="Rtt106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01286">
        <property type="entry name" value="SPT16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 10" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 10" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8 10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3 10" id="KW-0235">DNA replication</keyword>
    <keyword evidence="9 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 10" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="FACT complex subunit SPT16 N-terminal lobe" evidence="12">
        <location>
            <begin position="6"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="domain" description="FACT complex subunit SPT16 middle" evidence="13">
        <location>
            <begin position="495"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="domain" description="Histone chaperone RTT106/FACT complex subunit SPT16-like middle" evidence="14">
        <location>
            <begin position="736"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="398"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="847"/>
            <end position="978"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1014"/>
            <end position="1042"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="405"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="428"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="857"/>
            <end position="910"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="913"/>
            <end position="924"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1017"/>
            <end position="1029"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU367052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM01285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM01286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM01287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CAG5090888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="1042" mass="118183" checksum="20418B005DF0E697" modified="2022-05-25" version="1">MATVSLDKETFFRRMKRLYNGWKDGEVGTDDSFSKMDCLISAVGTDEDIIYSKSMALQTWLLSYELTDTIMILAEDCICFLSSKKKIEFLRQVESGKTEETGVPPVKLFVRDKSDEDKANFGKLIDVIKGSKKGKTLGVFSKENYPGAFMDAWRAAMKYLKDQIMEIIDSDKKVKHSKLAEGVDAAVTNKKYVTGVDTSQVDMCYPAIIQSGGNYTLKFSVVSDKNTLHFGTIICSLGARYKSYCSNIVRTLLVNPTSAIEENYNFLLALQEEIMKKMTPSTKISAVYETGLAYVKQEKPNMLDHLTKNFGFAMGIEFRESSLMIGPKTHALLKKGMVFNLHVGLSNLNNPAATDKEGKNYALFIGDTVLVGEPGAPATVLTNSKKKVKNIGIYLKDEEEEEEEGSGKENEPKPEILGRGKRTAVIESKLRTEHSSEEKRKQHQKELAQQLNEIAKARLAQQSGGKEEEKIRKSTVSYKSLSQMPREPEVKELKLYVDKKYETVILPVFGIPVPFHISTIKNISQSVEGDYTYLRINFFHPGATMGRNEGGSYPQPDATFVKEVTYRKEREKEDLVKQDTLVLTQNKGNPKLKDLYIRPNIVTKRMTGTLEAHSNGFRYTSVRGDKVDILYNNIKNAFFQPGDGEMIILLHFHLKHAIMFGKKKHVDVQFYTEVGEITTDLGKHQHMHDRDDLAAEQSERELRHKLKTAFKSFCEKVETLTKQEIEFDTPFRELGFPGAPFRSTVLLQPTSGCLVHLTEWPPFVITLEDVELVHFERVQFHLKNFDMIFVFKDYHKKIAMVNAIPMNMLDHVKEWLNSCDIRYSEGVQSLNWAKIMKTITDDPEGFFESGGWTFLDPESDAENEEVDDEEEEDDDAYEPTDIESEEESDEDSEYSEASEDSETEEEELGSSEESGKDWSDLEREAAEEDNERSNYPADTYTKNKKKSKHDTPSPSKNRHNRTDLEVGGHTRKCLLQNRPNIARRKATDMTSTSPLTHPHLPAKSDHAMTVLTEENPKNQGNKSGKSVSSELVGCTHSLQDNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HE91</accession>
    <name>A0A8J2HE91_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS6674</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5093219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HE91"/>
    <dbReference type="OrthoDB" id="7331812at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5093219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="64" mass="7547" checksum="EAA67FB37B4BFA21" modified="2022-05-25" version="1">MNAVKNYVENPKDWVPNKYTRISSTHFVNNEKSEHPLHPSYVLSIFPGRENIKRNKLFSNNCKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HEN3</accession>
    <name>A0A8J2HEN3_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS6646</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5093175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HEN3"/>
    <dbReference type="OrthoDB" id="8191915at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579">
        <property type="entry name" value="F5/8 TYPE C DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579:SF1">
        <property type="entry name" value="F5_8 TYPE C DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5093175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="561" mass="63890" checksum="8E232D55F9CF7A72" modified="2022-05-25" version="1">MDLSKNSKEKVFTVKRKIYKEYSYFGSSSSIPTRTKQYWAAKKKNRCENNDHCDVSISTVSLNRSSNESSNGSVIQDIEDNDECTTNTPNCFTSLNNDEEAASSNEISVQQNNNLVEEQNLSVNQYTFFLPSTRPNCNTIIVDNSSYSTDDLIAALTFLSVKLRHKLTYSATEDFVRGMSILNDLLVVKASKYHWKNIVNVFSDPVTIHHLCPECELYLGEQKKKIADDINREAEVLIEDFHDPIEDEYDTIHCDSCDKDIDRKLNISSGHSFLYFSLKYQLEQLFENSNVHCQLQQHREKMKKHAFEDIQDGKEYKKRIESDMISITFNTDGVPVFDSSNCSAYPILCSINELQPLKRKKHVLLAGLWVGTGSPNSLQEFFKPFVSEAEDLYQKGFEYIVGGKKFVRKCSALLSVNDALVRPKLRNSMQFNEEYGCGLCLNPGKRIEKGLGNVRIYPIESSNAYGEVLRTNTATIKHAESKEKVTVLTGKLTSGLLFYYFIYVDHWALLVDGISLLLQTSIMPSDIYYAYNCLIDFIIGVKDLYGEQELTFNVHSLAHLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HEP1</accession>
    <name>A0A8J2HEP1_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similar to spopla: Speckle-type POZ protein-like A (Danio rerio)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS8569</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5097155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HEP1"/>
    <dbReference type="OrthoDB" id="7624723at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24413">
        <property type="entry name" value="SPECKLE-TYPE POZ PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="141"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5097155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="301" mass="34127" checksum="182827D842EBE593" modified="2022-05-25" version="1">MGGSDSREITHNWELHEIGATWVISKPFGFPNSNTGTFYIHTAARNYSSGWDCLVKINKVGGININAKIAVKWNNKPLGPLTMINWTGLSDEFLFDGTPCQPPYNISCTIKLDDSINDKASDNPARELANVKDFFLSQEFSDITIKVGDQEFPAHKIVLACNSAVFKKMLTTEMKEKQENCIDLSEFDAESIKEVLRFLYGGEIEANDIDLLLKLSSFAHMYQINRLKDYCESKLVNNFQVDNIVKILVTIDNYDMDKVKNEAMEFLIKNKATVSFDDAIDNIKSSQVLRKFFSNLTQMKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HG03</accession>
    <name>A0A8J2HG03_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Metalloendopeptidase OMA1, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Overlapping with the m-AAA protease 1 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HICCMSTLAB_LOCUS7161</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="9">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6 9">Belongs to the peptidase M48 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5093835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HG03"/>
    <dbReference type="OrthoDB" id="7464992at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034982">
        <property type="term" value="P:mitochondrial protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006515">
        <property type="term" value="P:protein quality control for misfolded or incompletely synthesized proteins"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07331">
        <property type="entry name" value="M48C_Oma1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2010.10">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051156">
        <property type="entry name" value="Mito/Outer_Membr_Metalloprot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001915">
        <property type="entry name" value="Peptidase_M48"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22726">
        <property type="entry name" value="METALLOENDOPEPTIDASE OMA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22726:SF1">
        <property type="entry name" value="METALLOENDOPEPTIDASE OMA1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01435">
        <property type="entry name" value="Peptidase_M48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 9" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1 9" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 9" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="125"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M48" evidence="11">
        <location>
            <begin position="195"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00040360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00042978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAG5093835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="430" mass="49566" checksum="C6D0004D21C1490C" modified="2022-05-25" version="1">MLTLRRVLLINRKLIVKQSTVKLTVHRTSALGNNCYQFHLSRSLYNESSSSLAKISRRGLLRINNSILNKTPHRYISPTVALLIRPLTRIGALLFGRFFRKWWAKKTSEEKKLYIDWVSKQRQKIYGALGFFMASLFMFYIMNIEVDPLTGRSRFIIMTSNQQKVLGRLTFENYLENFKDFIVPTTHPAYKRLLRVVNRILEANQDLPQIKEREWTLSVIDKDDPNAYVLPGGNIFVHIGALKLTENDDQLAIIIAHEVAHVLLQHPIEQISRNLLQDILMAVPIAVVWALFPDLLALLLQALGINMFDILVTYPYSRKLENEADNIGLQLAAKACYDVRHAVVLWGIMRTLAELNIKPEVVPWLNTHPNHEDREKNLTKQLPLAIATRQQSGCPILNPADPIKYFNSLSLKEREIKMERRGFVQSKILL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HGW4</accession>
    <name>A0A8J2HGW4_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Gustatory receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HICCMSTLAB_LOCUS8004</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Cell membrane</location>
            <topology evidence="1 8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the insect chemoreceptor superfamily. Gustatory receptor (GR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5096027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HGW4"/>
    <dbReference type="OrthoDB" id="7698893at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030425">
        <property type="term" value="C:dendrite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043025">
        <property type="term" value="C:neuronal cell body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007635">
        <property type="term" value="P:chemosensory behavior"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008049">
        <property type="term" value="P:male courtship behavior"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050909">
        <property type="term" value="P:sensory perception of taste"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013604">
        <property type="entry name" value="7TM_chemorcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21143:SF133">
        <property type="entry name" value="GUSTATORY AND PHEROMONE RECEPTOR 32A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21143">
        <property type="entry name" value="INVERTEBRATE GUSTATORY RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08395">
        <property type="entry name" value="7tm_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 8 9" id="KW-0675">Receptor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="31"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="70"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="135"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="253"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="289"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAG5096027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="396" mass="47037" checksum="5137C59CACA72478" modified="2022-05-25" version="1">MHISSKIILKLLFYYFKILGFMPYVYYKPGILKRSISATIYTVILTLGYSKNVMNVMLSRSSFIRPRETILAVIVDFVSLMLDYIAISMIWIYSITRFNQVQDILKLFLKTLESTSVIMKIKMTKIYDDILREMFVFVLFLNILFIITVTTDLIVCYGEIKDYDFPVWTLFNYPRIIPLNYAMIHIYFIKILGRHFCLLNKNIGYLPEVYVDEDSSMEIIKIRLKPREIDEKLREFDKLDLELRNQIKMSNEIFALPFITVLLLQFTHSIFNSYLFMNSIMKKTFSWPILINVSWVLMRMLLLLSFIDNCHTVCEEANKKVKILHESWALKRLDGFKEMLKSISLHQLQEPVEIKFHDALKLNHELFYKMAGVTTTYLIIMIQLDQQVQNRHNHQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HHT2</accession>
    <name>A0A8J2HHT2_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS9509</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5100349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HHT2"/>
    <dbReference type="OrthoDB" id="7700848at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5100349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="60" mass="7232" checksum="063F52C94DC9BBC3" modified="2022-05-25" version="1">MKDARTRIKTETQQEWQDRWTSGETSRWTARLIPNINVWLSRKHDGFAQHTNVQILPRQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HI99</accession>
    <name>A0A8J2HI99_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Similar to znf346: Zinc finger protein 346 (Xenopus laevis)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HICCMSTLAB_LOCUS5961</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5092174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HI99"/>
    <dbReference type="OrthoDB" id="434647at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003604">
        <property type="entry name" value="Matrin/U1-like-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052644">
        <property type="entry name" value="ZMAT3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46786">
        <property type="entry name" value="ZINC FINGER MATRIN-TYPE PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46786:SF1">
        <property type="entry name" value="ZINC FINGER MATRIN-TYPE PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12874">
        <property type="entry name" value="zf-met"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00451">
        <property type="entry name" value="ZnF_U1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="379"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="232"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="392"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="41"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="406"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG5092174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="430" mass="46808" checksum="709372EDDBD01954" modified="2022-05-25" version="1">MSKGKVIENPEVPGFEQNLPPPPSLLLSSDIKDMDPAVLTAPPPPPPPLPANQVTVDPAVLTAPPPPPGPPIINSYYQSSMPQSVPWWIPTDADSQEAFWYDQSRYAPPAQEKPKKVQKRKHEVVDPVQDAERVAAAQRELTMLMKPLKCDLCNAVMNSTLQAKLHYDGKPHQKKVSMYLNQSVKRTKTETGPVNSEANNDWDSYCDVCKTWFTSQTDAAQHYAGKKHIRATTGAPKQKTHKKNSNQGPLDPTGRFGIGTGFQAGVPAVPAPPVPAVAPPIVPAPVPLAPVPPVPVCEVAVDSPPVMVDGFASGATSYGMALRCDLCGVSANRLEQLETHRRGARHLKMMRMSGLAPPESMQEPATIDYSIYRTPSGSYYCAPCNKSFTSENSFGQHVESKKHKNQVNTKTQSNQTTTAGKKDKKKTNKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HIC3</accession>
    <name>A0A8J2HIC3_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Large proline-rich protein BAG6</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="20">BCL2-associated athanogene 6</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="19">HLA-B-associated transcript 3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="25" type="ORF">HICCMSTLAB_LOCUS9444</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="25" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="21">Involved in DNA damage-induced apoptosis: following DNA damage, accumulates in the nucleus and forms a complex with p300/EP300, enhancing p300/EP300-mediated p53/TP53 acetylation leading to increase p53/TP53 transcriptional activity. When nuclear, may also act as a component of some chromatin regulator complex that regulates histone 3 'Lys-4' dimethylation (H3K4me2).</text>
    </comment>
    <comment type="function">
        <text evidence="1">Released extracellularly via exosomes, it is a ligand of the natural killer/NK cells receptor NCR3 and stimulates NK cells cytotoxicity. It may thereby trigger NK cells cytotoxicity against neighboring tumor cells and immature myeloid dendritic cells (DC).</text>
    </comment>
    <comment type="subunit">
        <text evidence="22">Component of the BAG6/BAT3 complex, also named BAT3 complex, at least composed of BAG6, UBL4A and GET4/TRC35. Interacts with GET4; the interaction is direct and localizes BAG6 in the cytosol. Interacts with UBL4A; the interaction is direct and required for UBL4A protein stability. Interacts with AIFM1. Interacts with HSPA2. Interacts with CTCFL. Interacts with p300/EP300. Interacts (via ubiquitin-like domain) with RNF126; required for BAG6-dependent ubiquitination of proteins mislocalized to the cytosol. Interacts (via ubiquitin-like domain) with SGTA; SGTA competes with RNF126 by binding the same region of BAG6, thereby promoting deubiquitination of BAG6-target proteins and rescuing them from degradation. Interacts with ricin A chain. Interacts with VCP and AMFR; both form the VCP/p97-AMFR/gp78 complex. Interacts with SYVN1. Interacts with USP13; the interaction is direct and may mediate UBL4A deubiquitination. Interacts with ZFAND2B. Interacts with KPNA2. Interacts with UBQLN4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Secreted</location>
            <location evidence="4">Extracellular exosome</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="25">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5100219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HIC3"/>
    <dbReference type="OrthoDB" id="1885901at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071818">
        <property type="term" value="C:BAT3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051787">
        <property type="term" value="F:misfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031593">
        <property type="term" value="F:polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002376">
        <property type="term" value="P:immune system process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007283">
        <property type="term" value="P:spermatogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01809">
        <property type="entry name" value="Ubl_BAG6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000161">
        <property type="entry name" value="Uncharacterized protein, isoform C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021925">
        <property type="entry name" value="BAG6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019954">
        <property type="entry name" value="Ubiquitin_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15204">
        <property type="entry name" value="LARGE PROLINE-RICH PROTEIN BAG6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15204:SF0">
        <property type="entry name" value="LARGE PROLINE-RICH PROTEIN BAG6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12057">
        <property type="entry name" value="BAG6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00299">
        <property type="entry name" value="UBIQUITIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="16" id="KW-0007">Acetylation</keyword>
    <keyword evidence="10" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="17" id="KW-0143">Chaperone</keyword>
    <keyword evidence="13" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0221">Differentiation</keyword>
    <keyword evidence="14" id="KW-0391">Immunity</keyword>
    <keyword evidence="18" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0964">Secreted</keyword>
    <keyword evidence="15" id="KW-0744">Spermatogenesis</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="24">
        <location>
            <begin position="2"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="75"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="164"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="342"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="432"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="565"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="630"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="23">
        <location>
            <begin position="76"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="23">
        <location>
            <begin position="168"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="23">
        <location>
            <begin position="343"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="23">
        <location>
            <begin position="443"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="23">
        <location>
            <begin position="566"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="23">
        <location>
            <begin position="578"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="23">
        <location>
            <begin position="633"/>
            <end position="665"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00021614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00029739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00030033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00046003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00046936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="CAG5100219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="1088" mass="118241" checksum="5AF334DE715196CC" modified="2022-05-25" version="1">MIDLTVKTLDSQNHTFSVNDDITVKQFKEHIAETVNIPDTLQRLIYCGRVLQDEKLLNEYDVNGKVIHLVQRAPPSLSQRSSNSNQNHTQNSIPGGEWPPMPRIHYRQAQFHGNPMYVSSVSFPADVLEGYELPIPQLNTSLTNRHVSVIRRMLDQANRVIDRLDNPSSSADSESASSTSQTPSQAPQEPAAESSSSESAATESKPPTPTPSASTSTPSASTESSSTNGTQSDALIPRDLAEVFDKLLTTQDRLRPYIRGLLQSPTSEATSSPEENQRMLDGVNECFHFLSHAQHALSNLNVNMQQPAPRTLRCRPITIQPSAILQAGLPIQVEAHINLHGQDANSDSDAASTTSTTNVTASTTNSSTNSTLRAEPTTTSDTSTPPSSAERPAETNPAAAVAAAAADSLSSMFNFSNNVEVVMEMGPQAPRVWTFSTGDQNQSSSSNNTNNNNNNNNNNNNNNNNNNNNNASTANNNNNNNNSSSNMTNGSTTTGTSGNAGAFPGAFPPPLPDIIRNVMQAVAGYMAQTNVTSSSIPVTQSVPTTTPGTGTSLGCLRHRGVAVTVGETTPSPGQSSQTRGSTETHPTTSTQTRTTPRTHVIQHAQALGLGLASSSSVDFDPFLPCNSHHIRRGQSSTTSTAASTQTGQGIADGSQPSQSSAGSSARTRLTTLAGVINPDNIFNNTPLADSLNNAAIMSNDDRPLSFNSVLIGRGINIMPDNILSTARSTQALFYIIYDVLGKIPMHSWINIVNGDTSSLRSVMQELQEKLRAHYQNREESDIPDAVIEDVFAEITIILDEAFRLPHIHHTFFAHRSIDLRQTVENLIRKHIKSIIQAIFSNADDTVETVLRHLNEFCSHLGAILRYSLRRDIDLLKMKSRFSKMITHGFPRLLREFVFQTIDNLFTKYSRQSALPSQSDLIPILVLKYDYGPMAATSSALNEIQSSSEDWVPIIARDGIRQRRQLALGLSDNNVTTLSDAYLATMPSKRRKIVEQQKPSLLVSPSSNSNSVVTASMERLVRESIGRAGSEEVDGAISALIAEPTVRRAFGEAIRESLNPRRYETPDFPDSLRFPNATKFFTDPNIPPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HK99</accession>
    <name>A0A8J2HK99_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BEN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS9765</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5100692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HK99"/>
    <dbReference type="OrthoDB" id="7696258at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018379">
        <property type="entry name" value="BEN_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579">
        <property type="entry name" value="F5/8 TYPE C DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579:SF1">
        <property type="entry name" value="F5_8 TYPE C DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51457">
        <property type="entry name" value="BEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BEN" evidence="2">
        <location>
            <begin position="939"/>
            <end position="1046"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="183"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="700"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="778"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1040"/>
            <end position="1142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="183"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="713"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="786"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="803"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="818"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1044"/>
            <end position="1056"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1060"/>
            <end position="1069"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1104"/>
            <end position="1114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1129"/>
            <end position="1142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5100692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="1142" mass="129840" checksum="7181C0889C11A9A2" modified="2022-05-25" version="1">MFAYIKILGTNELKIVNVNEIQKFKVDALPTKKFNIKIGHKTEQCTVSFKAETEEELLKLIESNRARFPPANICVTASEDDTQVNKVAKSSDLQNTNTQALLAKKLALKDKTSQMRKRAYNRLLNPSCSELLVSQRTVRSNLIPESFCKRDFENTEKIPSDNSSVADEETLSNDINNITSILSESSSSSQNSSEEVLTEYSTDTTMYSDSDDSWSDTDSNYQMQDSIVNDTTQSFNTDSLQGNREMFAASQLKTSGVLLMVESFSTSKNLTRTDHEDLINLIKVLAGPEFENWNPSQYKLSQIYDAPSDLIILHFFCEKYSVARPVCQNRVQFNAYWGCSWCYAPGTYFANSMRYPLTENDPDLRTNSRYKEDVKNAVRLNKNYVPRRRKTYKSSTPFIKLLPLFDNVWGYPIDYMHGCLLGVVRQLWALWTTAGTDFYLTKDNRDEIQKRLDNMKPPHEIHRLPGLIKNFSKWKASQLKSWLLYWSPICLNGILNKECFDSYLLLVRSIHTLLKRTITESEILRSEYDLLKFVGEFQSIYGLGAMTFNIHSLLYLGESVRRSGPLWETSAFPFENGIFYDKLNVNGPKGVSLQMSRKRLKKIRLRSKINASTTSNECANYCHKLFEPEEKLRNCVELPNNIRLIGEKLKTSQVEEAMKNYLQNQNIEIHIFSKCIYQQKIFHSSSYARANKTNDTFARFEMEGRTSQSTTNDKTEELNDTSKDDPLMHCLSDSTPEELINAGNNASMINSHKSTLSQLNIASNGSLNVNNDNSAVFDSLTAPKKSSSKRKRKNSNSKENKKKDKKAKIAKKNKKEKKKNDNESIDNEKRFTEIAGISKERERMKKGSDFSSDPITKRLTDITNIMNKSFADIKKTVAQIESKYSSELKELRGLVQILIDNWNEFKSMPSTSSSRALEERTGFPESGFVRRSDNSIHLGEGVYISKKTYDSIASDATSNAVFVKKIIMTQYTPEEIITYSVKGGKSNKIKMTSRKPGLDPTIRLAVKGIFRYYLSTRYTDEAYINAEVDKCDDHIRRKISDLRKKARPAKVPKSKKSSSSDDPSGSSSSDSDDAEPKKKSRNRNVSSGSDDSEKAEPKKKSRKSNASSSSNDSDNSSDHSRETTSQLGDKLESKENEPLGDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HKB5</accession>
    <name>A0A8J2HKB5_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">phenylalanine 4-monooxygenase</fullName>
            <ecNumber evidence="5">1.14.16.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Phe-4-monooxygenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">HICCMSTLAB_LOCUS9144</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-phenylalanine + O2 = (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tyrosine</text>
            <dbReference type="Rhea" id="RHEA:20273"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:15642"/>
            <dbReference type="ChEBI" id="CHEBI:58095"/>
            <dbReference type="ChEBI" id="CHEBI:58315"/>
            <dbReference type="ChEBI" id="CHEBI:59560"/>
            <dbReference type="EC" id="1.14.16.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 13">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid degradation; L-phenylalanine degradation; acetoacetate and fumarate from L-phenylalanine: step 1/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the biopterin-dependent aromatic amino acid hydroxylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.16.1" evidence="5"/>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5099607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HKB5"/>
    <dbReference type="OrthoDB" id="983542at2759"/>
    <dbReference type="UniPathway" id="UPA00139">
        <property type="reaction ID" value="UER00337"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004505">
        <property type="term" value="F:phenylalanine 4-monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048066">
        <property type="term" value="P:developmental pigmentation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042416">
        <property type="term" value="P:dopamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006559">
        <property type="term" value="P:L-phenylalanine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd04904">
        <property type="entry name" value="ACT_AAAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03347">
        <property type="entry name" value="eu_PheOH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.800.10:FF:000004">
        <property type="entry name" value="Tyrosine 3-monooxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.800.10">
        <property type="entry name" value="Aromatic amino acid hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001273">
        <property type="entry name" value="ArAA_hydroxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018301">
        <property type="entry name" value="ArAA_hydroxylase_Fe/CU_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036951">
        <property type="entry name" value="ArAA_hydroxylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036329">
        <property type="entry name" value="Aro-AA_hydroxylase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019774">
        <property type="entry name" value="Aromatic-AA_hydroxylase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041912">
        <property type="entry name" value="Euk_PheOH_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005961">
        <property type="entry name" value="Phe-4-hydroxylase_tetra"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019773">
        <property type="entry name" value="Tyrosine_3-monooxygenase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01268">
        <property type="entry name" value="Phe4hydrox_tetr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11473">
        <property type="entry name" value="AROMATIC AMINO ACID HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11473:SF24">
        <property type="entry name" value="PHENYLALANINE-4-HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01842">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00351">
        <property type="entry name" value="Biopterin_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000336">
        <property type="entry name" value="TH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00372">
        <property type="entry name" value="FYWHYDRXLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="ACT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56534">
        <property type="entry name" value="Aromatic aminoacid monoxygenases, catalytic and oligomerization domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00367">
        <property type="entry name" value="BH4_AAA_HYDROXYL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51410">
        <property type="entry name" value="BH4_AAA_HYDROXYL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12" id="KW-0408">Iron</keyword>
    <keyword evidence="6 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-0585">Phenylalanine catabolism</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ACT" evidence="16">
        <location>
            <begin position="49"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="Biopterin-dependent aromatic amino acid hydroxylase family profile" evidence="15">
        <location>
            <begin position="118"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="297"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="302"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="342"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00029922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000336-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR601273-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51410"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CAG5099607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="465" mass="53096" checksum="2C13B97D907C8891" modified="2022-05-25" version="1">MNNPVDIRPRERENDEEILSSSPPDKPKLMEGGNYIKEGRDSARSTCLIFSPNEEDEVGALGKYLQIFSEHKVNLLYIESRSSLRKVNGYEFVVECAPGGNLGAAIEAVKEQCSYFSIISRNHKNNMDSVPWFPRRIRDLDKFANQILTYGAELDSDHPGFTDPVYRARRKYFADLAYNYKHGEPIPQVEYTEEEIATWGVVFNKLTELYPKYACREHNHVFPLLIENCGYRADNIPQLEDISRFLKDCTGFSLRPVAGLLSSRDFLAGLAFRVFHSTQYIRHSSKPLYTPEPDVCHEVLGHVPMLADPAFAQFSQVIGLASLGAPDEYIEKLATCFWFTVEFGLCRQHGELKAYGAGLLSSFGELEYALSGEPELRAFEPAKTALQKYPITEYQPVYFVAEDFEDGKEKMLKFAQTIPKKFGVRYDPYTQSINIIDSKYQIEELIINVNQEIEILMDAFKKLKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HKH8</accession>
    <name>A0A8J2HKH8_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS7460</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5094940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HKH8"/>
    <dbReference type="OrthoDB" id="7932313at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032062">
        <property type="entry name" value="DUF4803"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47890">
        <property type="entry name" value="LD24308P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47890:SF1">
        <property type="entry name" value="LD24308P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16061">
        <property type="entry name" value="DUF4803"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5094940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="625" mass="72747" checksum="9B4556EAC43AFC93" modified="2022-05-25" version="1">MDEEDRNNEIKNFVSEMLKTFNSFNETDNYKSTFPWDEFDKKLRDHRMNKNNSLSLLPHIIFQDLRLELNILESLIHRFFKNKVSSHIDDIQNLCSFPLSHTISQSKLTYSYIEESYKALTGEIERREAKSETTDVDCDEHLFLQDLYELSKEILRGFVLKFFRSSIGLSLKSKCTVESEENVKKKLLHQRNHFMNNVTMFMNFTRNYLGNFSEYLYACDFSNHTRDKTYIELERMYQVMIENEFYLDKDGSCSYNCNTKGEHFKPHVDYMCKDLDCQYMGAKFEICQLDDDVRRYQWFKDGNNNVYGNNTNCSGKMVTYNSWYQWTTRYCDYCLCVCTAKLHREVHNEITAISFQDQVSDTDSSKVVLDLKFVIKNNTIYVEIKEGKLLPHGKIDNNSVAWKALDNCTIFDNFTFCTYPPLNGLAYGLTTAVKDFGYPEYLNLDDIKASTESIVTGVRFRFAGDFNTHPRYKNGSVEMQIRLTDFDYLTGKLSKNHVWISSNNKQNKTELLLPNPDNPIKSPKNIPNLKGNQFVKFKVSDLKKDAGQSTVPFFDARPVESKVLFPLKGIGLFHRGYEGFGGFIAFKLFIISPQEYMNTDLGVTNSVTPASINTDWNIFSGLNWP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HKX6</accession>
    <name>A0A8J2HKX6_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Similar to Hivep1: Zinc finger protein 40 (Mus musculus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HICCMSTLAB_LOCUS10652</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5101751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10042249at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000594">
        <property type="entry name" value="Transcription factor HIVEP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000145">
        <property type="entry name" value="Zinc finger protein 574"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003604">
        <property type="entry name" value="Matrin/U1-like-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051969">
        <property type="entry name" value="Zinc-finger_DNA-bd_regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45944">
        <property type="entry name" value="SCHNURRI, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45944:SF2">
        <property type="entry name" value="SCHNURRI, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SMART" id="SM00451">
        <property type="entry name" value="ZnF_U1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035179496" evidence="11">
        <location>
            <begin position="24"/>
            <end position="1892"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="101"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="129"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="1067"/>
            <end position="1094"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="1095"/>
            <end position="1119"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="1625"/>
            <end position="1652"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="1653"/>
            <end position="1682"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="1698"/>
            <end position="1727"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="52"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="149"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="298"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="395"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="508"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="780"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="896"/>
            <end position="927"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1149"/>
            <end position="1181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1280"/>
            <end position="1300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1728"/>
            <end position="1779"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1798"/>
            <end position="1824"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1858"/>
            <end position="1892"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="69"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="172"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="329"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="339"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="395"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="412"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="513"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="780"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="1155"/>
            <end position="1176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1728"/>
            <end position="1737"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1761"/>
            <end position="1776"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1864"/>
            <end position="1880"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1881"/>
            <end position="1892"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAG5101751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="1892" mass="208905" checksum="EFB7AD59A9A6441B" modified="2022-05-25" version="1">MIIHFISAIHYFVIANLTIKTQAVAMTDPQLANNTSCNNNNKTNPIKTIIHQTDSSEVTRRAPASDVTKSINNNNNSKESSKAKESSESSSEPPETKKTGYVCPYCKMSCSKPSVLQKHIRAHTNERPYPCLLCGFAFKTKSNLYKHRRSRAHTAKAEGTADQAKVSEDSDISLSDSASNGTGTPPPLASSVVASNHLEAATKTVKTGKIYKPKFHTALESVNNDPESLSVSPLATTISTSTSSLLSSSSIISSSSNGTSTVSIKPNAEQLQEHIDKIITDNQAIVEAVDPRLHKLMHRQQSHPAKPSEQPLNLSSSPEVVLSSRKRHLGDTQEDKNQKPQLNLHLQSEPANQGSIIKDLLLKNRDDFVCANCKISYTSADNLEAHKRYYCKVSSSSSSLSSSSSSSSSPSPKRDFQLDLEKRDNDDTKSEYYNTVKPLPSPGPLLGNTRLVDAYTPPVKKHCLTELTVPPTSLRSLEELSKYPRPNSLQMFGGQVRILDNTGETKTMRIEPRQTNSPSDDMTNHNSKSGTSETSSIVVRSSLHSGGTMVHKPPGGTSVSSSVTNSLSNSISMPNAPQMLAPIIPNISTPNIAPTMTCYGNYLEPRLNPLTITAYNPLTLPSGISSIMHGGKIIPYVPGMPGPHTLMSDISQPQTDSYKLPVPGAQPLDLASPVKVGATTPYVPGIPGPEDSVKPLFTPLDLAKDPKVGFKLPTNGGVISPKIVQGDNKYRRLSSCDFKNNNNPEVDNNFDRHIHKNSKYKLKDNYDKNFKTDNVNINGNVNFERSSPKLTENRKRPASWGDDGSINDRRSPLVAKYEHGEGRVRMSPETVANGVFLNGRARAESVPPVIIMDLDTASIQQEPKSSPELIVSLDSKQSPSLEREVEEKTTKFLRPSSLPLKPGTFTPKRHHGITPTPYTQPLISPETPRPRKSYGQLYLNGHAYTYLGLKCSTRVYYCTLNRPQPMYVTQQHHLSMYSNWKIFNDLRPDRNLANYDSRNRSSSYTIAWKKQELLLTHSSYKPVKLNSSPSPDSDSAQKMARRIKIFDGGFESNEDYTYVRGRGRGRYVCEECGIRCKKPSMLKKHIRTHTDVRPYTCKYCSFSFKTKGNLTKHMKSKAHYKKCRELGIDPVPTTVCDENIDKEAIARLTAGGGENADESSEEEDDESDNEESEESGTDEHEAARSLLILSQPSKNRLQIPGLVPACRPATYPYALTTLLSTSTSTATTTTASTGSVTSATVIQSEAASNRYYFPSRSLDSSRDSVIRSTKVEEAKEEIIEGPAGEAEDHQGTRGTTQPMDLTTKPAILDCAKRSSVDILTPVSEPILMQTIVQTMERLPPGREWKPDAEGHMLQAYLTERHVMDSKIKQQYRVGGFKVEKKVFSGSKLENSRGSLFSSSTPTVTYTDSRMQFAGKKEDVGQKVEAKSERRPFDIESLHSQELLRPRVNTQEYLVGRNYPEVGQELKPLGNETREAVASHERQDFIPSPGREARYERPVRPVSAGLEFKVPCSEFKDRETPDTKEFRPMEPRLVNEIGLRPLHDARSNSERVLADVKINVEGLGKQIGVAVVEGIKQQHNVVRKMVVAGPGFRSPSPSRAGKPMAEFLPPSGVAPNYVSIGEDGRSTCGICNKVFNKPSQLKLHINIHYFERPFRCESCAVSFRTKGHLTKHERSVSHHNKVSMTSTFGAPTTSNPRPFKCTDCKIAFRIHGHLAKHLRSKMHIMKLESSQYQQSIPPTTTTTTTTSSGEASSDEGEPIPQFPVSPTSSPSAFTPATDIPSSVSRAYHSPILSVISDRNKSPVESHVPNSRFEDKNLPASSSSSVDTHLPNAFICQTCTTSFRNLVDLQVHCFVEHNIDNRNHPSESGPTNENNIKQTNDVDINKVHDKSDDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HL49</accession>
    <name>A0A8J2HL49_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Similar to ZNF836: Zinc finger protein 836 (Homo sapiens)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HICCMSTLAB_LOCUS12495</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5106908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HL49"/>
    <dbReference type="OrthoDB" id="9411774at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000446">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000478">
        <property type="entry name" value="Zinc finger protein 133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000295">
        <property type="entry name" value="zinc finger protein 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000688">
        <property type="entry name" value="zinc finger protein 197 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000110">
        <property type="entry name" value="Zinc finger protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1800.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012934">
        <property type="entry name" value="Znf_AD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24381:SF393">
        <property type="entry name" value="CHROMATIN-LINKED ADAPTOR FOR MSL PROTEINS, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24381">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07776">
        <property type="entry name" value="zf-AD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00868">
        <property type="entry name" value="zf-AD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51915">
        <property type="entry name" value="ZAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="12"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 8" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="ZAD" evidence="11">
        <location>
            <begin position="76"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="366"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="394"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="423"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="451"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="479"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="560"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="588"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="616"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="644"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="674"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="702"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="730"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="172"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="243"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="172"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="243"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="259"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="78"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="81"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="124"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="127"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAG5106908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="759" mass="88051" checksum="935AFD077456E344" modified="2022-05-25" version="1">MEPKSSIPYQQCDETKLVASVKKIVYTNVIETNNKYLIFNNELNQQNIADSISTTMLDDTNIYCGEQENSEINLQDLCRVCGNTNNHMVPIFGDEGLQHDLINKISRYLPINVTKNDTLPLQLCYNCASTLIAWHDLLERCLDAEQKLLGIEERLLSKNQIDKSDDLETVQQSVSHVESNPVPQSLEHEKESIPENSKTPSEERSSFIQTRSITSRCMRKNSITSHDKLEELPRPMVEQIDQEPEAYSEDNDDSCASEDEARVNNGDKDKDKDLHDSSDETERKLEQKDNKRNSKTQQESQVKPSRPRSYPCMYCDFIGNKKKLLQAHMIEIHPDVLMDDLIKKPSCVDKEMIENARMEADGRVYYHCEDCGKNLFSPYTFFWHKRIHTGERPFCCHLCGKQFRVNQGLARHLHETHEGIKNFSCDICSRTFATKRTLDDHRRIHTNERPYVCNRCGKTFKQKASLFVHNRTHSDVFPFKCVHCEQSFRTRPTLMVHITKHTGEKPFVCEICNRPFRIKFPSGRRRLQIKKKRVTREKRTTEQKALILNSKIIVDGINYYKCSDCNKVLSTVYNFLTHRNTHSEDTPYVCETCGKGFKAASALIRHRAIHGGRKKYPCDLCGHVLSSKSAIEEHLRTHSSDRPFVCQFCDKSFKQKSALYSHKKFHLTDATSKHKCSTCERVFPRSQELKKHILVHTHEKPYCCDICGKKFRTSGCVSRHKRIHATEKIHKCNICGAQFGQKRYLKNHCRYKHKTTTTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HL51</accession>
    <name>A0A8J2HL51_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Integrator complex subunit 11</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Cleavage and polyadenylation-specific factor 3-like protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">HICCMSTLAB_LOCUS12078</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. INTS11 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5106062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HL51"/>
    <dbReference type="OrthoDB" id="10249535at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:RNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031123">
        <property type="term" value="P:RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016180">
        <property type="term" value="P:snRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16291">
        <property type="entry name" value="INTS11-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10890:FF:000002">
        <property type="entry name" value="Integrator complex subunit 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.15.10:FF:000003">
        <property type="entry name" value="Integrator complex subunit 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10890">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022712">
        <property type="entry name" value="Beta_Casp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041897">
        <property type="entry name" value="INTS11-like_MBL-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048662">
        <property type="entry name" value="IntS11_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050698">
        <property type="entry name" value="MBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011108">
        <property type="entry name" value="RMMBL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11203">
        <property type="entry name" value="CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11203:SF37">
        <property type="entry name" value="INTEGRATOR COMPLEX SUBUNIT 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10996">
        <property type="entry name" value="Beta-Casp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21386">
        <property type="entry name" value="IntS11_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16661">
        <property type="entry name" value="Lactamase_B_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07521">
        <property type="entry name" value="RMMBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01027">
        <property type="entry name" value="Beta-Casp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="12">
        <location>
            <begin position="16"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-Casp" evidence="13">
        <location>
            <begin position="245"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00016810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00029625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM01027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CAG5106062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="617" mass="69815" checksum="FCA110004858F366" modified="2022-05-25" version="1">MPDIKVTPLGAGQDVGRSCILVSMGGKNIMLDCGMHMGFNDERRFPDFSYIVPEGPVTNYIDCVIISHFHLDHCGALPYFTEMVGYTGPIYMTHPTKAIAPILLEDMRKVAVERKGESNFFTSQMIKDCMKKVIAVTLHQSVMVDPELEIKAYYAGHVLGAAMFHVRVGSQSIVYTGDYNMTPDRHLGAAWIDKCRPDLLISESTYATTIRDSKRCRERDFLKKVHECIDHGGKVLIPVFALGRAQELCILLETYWERMNLKVPVYFALGLTEKANNYYKMFITWTNQKIKKTFVQRNMFDFKHIKPFDKAYIDNPGAMVVFATPGMLHAGLSLQIFKKWAPNEQNMVIMPGFCVQGTVGHKVLAGAKKIEFENRQVVEVKMAVEYMSFSAHADAKGIMQLIQYCEPKNVMLVHGEFAKMEYLKEKIKQEFGINCYNPANGETCVITTMSKVPVDASLELLKAEAKRYSALPPDPKRRRLLHSVLMLREDSVSLVDAEEVGKAAGIPRHVVRFTSTVQIKDPGPVQSTTMKLFQPLKERLNAWNVQLTDGAISVESVLVKIEGSDEDQKNVYVSWTNEDEDLGSYILGFLQTIPVIQLQKIFHNYWLGKFNNRSDNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HLB5</accession>
    <name>A0A8J2HLB5_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">Eukaryotic translation initiation factor 3 subunit E</fullName>
            <shortName evidence="5">eIF3e</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Eukaryotic translation initiation factor 3 subunit 6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HICCMSTLAB_LOCUS8049</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex. The eIF-3 complex interacts with pix. Interacts with mxt.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5 6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the eIF-3 subunit E family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5096117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HLB5"/>
    <dbReference type="OrthoDB" id="417252at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071540">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex, eIF3e"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd21378">
        <property type="entry name" value="eIF3E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03004">
        <property type="entry name" value="eIF3e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016650">
        <property type="entry name" value="eIF3e"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019010">
        <property type="entry name" value="eIF3e_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10317">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09440">
        <property type="entry name" value="eIF3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016255">
        <property type="entry name" value="eIF3e_su6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01186">
        <property type="entry name" value="eIF3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 5 6" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3 5 6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="7">
        <location>
            <begin position="223"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00047068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR016255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG5096117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="437" mass="51287" checksum="72AB06079AAAF62C" modified="2022-05-25" version="1">MAKFDLTCRIGQYLDRHLAFPLLEFLDTKRIYDENELLQAKLDILSKTNMIDYVIDIRKQLYPDKEVPEELKARRAEVVRELGTLQNNVSTVVGWMNDEKVMKKMEEMRDSKALNNYLVQDLEFKIEMMDGLVKLAKYRYECGNYSISTSYLYFYMLIMPPTDKNYLNVLWGKLASEILAQNWDTALEDVNKLREYIDNNAIGNSLHVLQQRTWLIHWSLFVFFNHVKGRDLIIEMFLYRPHYLNAIQTTCPHILRYLAAAVIVNRSKRSTLKDLVKVIQQESYTYRDPITEFLEHLYVNFDFDGARQKLQECQTVVFNDFFLIALLSEFVENARLMIFETFCRIHQCISIGMLAEKLNMKADVAECWIVNLIRNARLDAKIDSKLGHVVMGGQPASPYQQLVEKIETLSVRSEALENLIERKLKAKNQDRVSIVWN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HLK0</accession>
    <name>A0A8J2HLK0_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Similar to rst: Irregular chiasm C-roughest protein (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HICCMSTLAB_LOCUS9919</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5100846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HLK0"/>
    <dbReference type="OrthoDB" id="10039395at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005911">
        <property type="term" value="C:cell-cell junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050839">
        <property type="term" value="F:cell adhesion molecule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098609">
        <property type="term" value="P:cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013162">
        <property type="entry name" value="CD80_C2-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051275">
        <property type="entry name" value="Cell_adhesion_signaling"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11640:SF154">
        <property type="entry name" value="IRREGULAR CHIASM C-ROUGHEST PROTEIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11640">
        <property type="entry name" value="NEPHRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08205">
        <property type="entry name" value="C2-set_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="2 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035196933" evidence="7">
        <location>
            <begin position="24"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="559"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="8">
        <location>
            <begin position="25"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="8">
        <location>
            <begin position="135"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="8">
        <location>
            <begin position="242"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="8">
        <location>
            <begin position="349"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAG5100846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="675" mass="75295" checksum="EFA4FAD88DE25BE7" modified="2022-05-25" version="1">MVKIRAIVIACFMSGVVFVGVNSEQRFIETPPSYQEVSSGEDVKLVCKVQDKKGQCIWQKDRKPVGMHPDKYEWANGRGGGGGGDADCTLLIRRASLDFDDGLWECQVTPGDFTRQDALTSLASRLLVRVKPRKPSLEYGGTIMTGALTLREGQEVTISCVSRYGNPPALIKWFIGGDEVEPLREQTNATEVDSPKTWAAHSLLRIKGARENHGLPIRCLSLHSSSPLPAIAESRLDIHYSPEVHTETSPRLLTSALEDSASFMSIKCIADANPPAAIRWYKDSVPLTRSNSIDSFGQNSTHRNGTMSGSEIRFEPVKQTDAGLYTCKGINVIGESSPANYRLDIQYGPRMRINDRMNNTNGEVEVTALLASTVDPFECDDFDANPPARYRWVHLRGGVPQTIDNSVHGETGSRRLSLKNVIWSNEGEYRCVAFNIINGVRREMSSDTRFILHVSGPPEIQTRRYNHNNDDDNDRLSDNISMDESIAWVGESIEPKYEALPLEPIKESNETTNCYYAKLEIRDLQKEDSRVYNLLIESEKGRDTTSLRLIVRDPMEIKIIAIAGGIGLLLLFVIIGLVFYAILKARHRKYQKKRAEEEDENSIAADAFYTTTPSINRQKTTASPANKVYVRKSPSEGGLAVMYDYNQIVKHSRTLSPEALKIRRAAAVLQPPTIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HLP9</accession>
    <name>A0A8J2HLP9_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Similar to vanin-like: Vanin-like protein 1 (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HICCMSTLAB_LOCUS10835</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the carbon-nitrogen hydrolase superfamily. BTD/VNN family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5102078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HLP9"/>
    <dbReference type="OrthoDB" id="10250282at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040154">
        <property type="entry name" value="Biotinidase/VNN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043957">
        <property type="entry name" value="Vanin_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10609:SF14">
        <property type="entry name" value="BIOTINIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10609">
        <property type="entry name" value="BIOTINIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19018">
        <property type="entry name" value="Vanin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="546"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="domain" description="CN hydrolase" evidence="4">
        <location>
            <begin position="45"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAG5102078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="569" mass="63290" checksum="9DE51EAF27DDDB7C" modified="2022-05-25" version="1">MDLFKTPGNSCRKCGRCIRKVDTENFSRALVHIPPTASSPTSNYYIGAVVEYHPVTKGDNGTAIANENAKNYLTFLKTASENEVDIIVFPENALFSGKTYPLNERSNYLPHSTYLPHPKDSKVPCHDTSSNVMEAVKAMSCAAKRHAMYIVINVREKEKCTGENCSKDGHNLYNTNLVFDRTGAIVAKYRKWNLFGEAGMNRTSKPDISTFRTDFDVNFGQFICFDLLFGTPAIKLVREKKVTDIIFSSHWFSELPFLTANQIQTGWSYAHNVNFLGSGYNNPATGSGGSGIYGGKDGHFARIWSEKSANALIVAKIPKIVNGQHSQPINPNDAMVFFYSITEIPTINQQEPVPQQKIKMDDLSPYTTELFQPANGTHNLTLCNNDLCCNFTTNTVHRDDMVQGAAKYYRYRFAVFNGVRSFSNIGTGGVEVCSVISCLDENPTSCNQRFDTNTIIVHPTTFNSIVISSVTKDSSNVTRLPLSINTELHPLNVTDFTFVSNKINATHVSLKYTLTKPRKDLMTFAIYGRNFTADGLPKTTSASAQIIPPIYLMSILFIILAMGNTYQHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HM39</accession>
    <name>A0A8J2HM39_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similar to v1g238856: Quinone oxidoreductase-like protein 2 homolog (Nematostella vectensis)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS11659</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5103737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HM39"/>
    <dbReference type="OrthoDB" id="3509362at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051397">
        <property type="entry name" value="Zn-ADH-like_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43677:SF4">
        <property type="entry name" value="QUINONE OXIDOREDUCTASE-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43677">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE/REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="1">
        <location>
            <begin position="62"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5103737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="426" mass="47651" checksum="A07F851ED4B1D535" modified="2022-05-25" version="1">MSVIKCRLATNWVWKCNKLLLNINTRRLSKNTESDEKNVIPPREEGKMQGAVLKKFSEPFIIDNLDIPSINANEVLIDVQYCTLNGPDILKMKNLHRSPPKLPAILGYEVAGKLLEVGDQAKKQGFKVGDKVVALNKVQFGGLAERCVAEMTDIWKIPSSIKTLDTVCLMNNYLTALIGLEKKADLQENEIVVINVGLSGVEIVRDKGAFASLKYSDKKLMKKIVEFAAERDIKDVFDGAEGEKFKTMLECFTSIYKEDHQNSLLRDDNFAVLIEHLSREGRIIIAGFAVTKEDYDEDSSTQCPFSITGIDIVEFKEKNLESYREAGNDILQYHEEGLIKPSYSMVVGLHKINDAVKFITDLKCSDKVVVDLKNPEAEIKLKDKPGHEPGSFGYAPNALPVKLSETPSGPDPGLGRPNYFFSQIYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HN78</accession>
    <name>A0A8J2HN78_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to Saysd1: SAYSvFN domain-containing protein 1 (Mus musculus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS12519</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5106956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HN78"/>
    <dbReference type="OrthoDB" id="71310at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039159">
        <property type="entry name" value="SAYSD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019387">
        <property type="entry name" value="SAYSvFN_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13527">
        <property type="entry name" value="SAYSVFN DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13527:SF0">
        <property type="entry name" value="SAYSVFN DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10260">
        <property type="entry name" value="SAYSvFN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="domain" description="SAYSvFN" evidence="2">
        <location>
            <begin position="76"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5106956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="154" mass="17974" checksum="09379063BF64C61D" modified="2022-05-25" version="1">MEAKLAAYRLQKRRQAMVENAKKTFHQTLTSWEDKSRAYLTRREDKDEIESVTSEESIDISPQQNPVMTRLIYLLYFLLWATLYMVAIQFEFGAVYFILSALFFIWKNTRSGPKKKGEVSAYSVFNPNCEAIQGTINMEQLEREMGFGVPIHSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HN95</accession>
    <name>A0A8J2HN95_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Similar to PGAP2: Post-GPI attachment to proteins factor 2 (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HICCMSTLAB_LOCUS13785</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PGAP2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5109149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HN95"/>
    <dbReference type="OrthoDB" id="68581at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019402">
        <property type="entry name" value="CWH43_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039545">
        <property type="entry name" value="PGAP2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12892">
        <property type="entry name" value="FGF RECEPTOR ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12892:SF11">
        <property type="entry name" value="POST-GPI ATTACHMENT TO PROTEINS FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10277">
        <property type="entry name" value="Frag1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="3" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="30"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="88"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="118"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="151"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="190"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="228"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="domain" description="CWH43-like N-terminal" evidence="9">
        <location>
            <begin position="27"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF10277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAG5109149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="259" mass="30518" checksum="3EEF2F6B85F62A5B" modified="2022-05-25" version="1">MNRMRLNSDYIPLIDEEAPRYRIVIPFKKLAWFTVALPFFGFIFCVVWSVTYNFEHATSTHCNVYNVLPSISAAIGHYEPQRDVWKTAIAIQAVIRALIFVMYYYYYQQTTYRWAQGVINIALFSYAVENISLVTLSFWTSNQNYAFHKLSFITFLLMSFVHMMVATYICKNCRSTPRDPSESKSSVLKVRAMLLNVISILSACYFFWRHNRYCEPFVYSMFAFSEYMVVMTNMLFHLTAAWDFAERRLLISTRGLRIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HNH7</accession>
    <name>A0A8J2HNH7_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Similar to FPV162: Putative ankyrin repeat protein FPV162 (Fowlpox virus (Strain NVSL))</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HICCMSTLAB_LOCUS11627</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5103673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HNH7"/>
    <dbReference type="OrthoDB" id="20872at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050745">
        <property type="entry name" value="Multifunctional_regulatory"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24189:SF50">
        <property type="entry name" value="ANKYRIN REPEAT AND SOCS BOX PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24189">
        <property type="entry name" value="MYOTROPHIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="34"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="68"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="121"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="223"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="257"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="334"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="369"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="404"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="436"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="469"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="506"/>
            <end position="536"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG5103673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="571" mass="64702" checksum="076A08F5E4CF6331" modified="2022-05-25" version="1">MPLTELHKVIKKLDFKAFESLIERSTDINAVDDENKTPLHYAFANNHQGTMISSLIDRGADINARDNEGKTPLHYAVDDFTTKVNKYSPKYNKNCGMSVYSFIMLEHLLNKGPDINAVDNENKTPLHYAAENRTNRQIVEFLLSYKPDINAVDNKKKTPLHYAAQNRFKAMFFECVSSTEEEIDTVADNPEAGEESQDNDFNDEFIVKNLVDAGAIVDAVDNEGRTPLHLAIYHSNDPIAIKYLIDHGADVIAADHEEKQPLHLAAQHPAAKEIFEYLIEQGADVNVVDRWKQTPLHYSVIRSYPINRNDENQIDERVECLLKHGANVDAVDYKGKTALHYAVISKKNSLEIIESLIRHKANVDAVDYKSKTALHYAVVSQKNYLKKTELLVKNKANVNAVDDECKTPLHLALENSIPVWKFLIDHGADVNSKDRAHRTPLHYAVSKGCIEIVKYLVEHGAEVNARDDEDKTPLHLAFGPSLTYNLVEYLIDHKADYNATDRWLETPCHLAARSTDAEGILEYLVDRGANFTAMDYYLNIPSLRLVMESDSDEDDNPPLEIVKNLKRLRDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HNV0</accession>
    <name>A0A8J2HNV0_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS11218</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5102856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HNV0"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5102856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="63" mass="7251" checksum="6B97E3B78A9ADE73" modified="2022-05-25" version="1">MRLRKSSTERSREFRARKKQLLNNQNRCSNISVNVTGVINDHSQQQNSVPTGYNLVNNDFGKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HP44</accession>
    <name>A0A8J2HP44_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similar to Fbxo39: F-box only protein 39 (Rattus norvegicus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS12111</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5106128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HP44"/>
    <dbReference type="OrthoDB" id="9974792at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031398">
        <property type="term" value="P:positive regulation of protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20933">
        <property type="entry name" value="F-BOX ONLY PROTEIN 33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20933:SF3">
        <property type="entry name" value="F-BOX ONLY PROTEIN 33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5106128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="428" mass="49754" checksum="DD1E8D43A14DFD02" modified="2022-05-25" version="1">MWDQLPELILTLIFDHLECRDRFSVDRTCQSWRRALAAPVLWRSITIFIDRDLRSDSSPTKQLAGKYGQYIRKLELAWSRPYILPSETRATWNIRAKEGVEFIAIIKKKAVQLKQFVLTDWFFGSNWNHRSKLLYAVAHFLRCQRNLTSLSLLNANLGVSDVLRLFRAVSWSCGDSLEYLDIRGAFKDWQAPHSNSRYLQYLERLHTLTTFKLDYPALSDLALNSLALAAPKVLRELHISVRDSDARQHTIQDAAWHNLVAVCPQLTVSYTIVNISHYEDISYLLVPSVPLSRFHMYGGHVWDQSRSRNFRTTIGLLISYYSKSLSEVMLQLRNNREQLDDLLVSLVERCRRLTNFQYNGIIRSVGTLQEILNLQIDNKTSFRTIHVKPSTVNLRNRGALDEINYNYNHRMLDRGIDFRIDGPALSFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HPL8</accession>
    <name>A0A8J2HPL8_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to AUTS2: Autism susceptibility gene 2 protein (Homo sapiens)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS13505</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5108869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HPL8"/>
    <dbReference type="OrthoDB" id="10060000at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023246">
        <property type="entry name" value="AUTS2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14429:SF22">
        <property type="entry name" value="AGAP013055-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14429">
        <property type="entry name" value="FIBROSIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15336">
        <property type="entry name" value="Auts2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="29"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="268"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="344"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="406"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="659"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="757"/>
            <end position="991"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1035"/>
            <end position="1086"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="57"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="89"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="124"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="176"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="268"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="364"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="435"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="455"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="659"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="670"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="779"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="895"/>
            <end position="909"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="916"/>
            <end position="932"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="936"/>
            <end position="949"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1074"/>
            <end position="1086"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5108869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="1086" mass="117525" checksum="6B32B8066E2C9720" modified="2022-05-25" version="1">MDTVDISAIKLAGKNNVKKLHSLLSIVEEKPKGLDAGTSDDSGRASEQLHGPGIPRDCQDADSSRDHLSDGSDAESILFESSTPPLPHELPSSSPHVLPPANGAGGSPPDTGGQISNPATDAPAPIPPPVPASAPVPTAPSPPSPTLPPHISQSPMTSPLAANPRAIAPQQRPASPALPPPSLPQQPHTPIPPALHPPNVPFVPSSHTTTSPAVASLGVTPAAPSNGAATSTSYPPPLPMAVYPQPPPSHPPLYTPYATLNHSPYLPSAVSSPSHSASSRTDVRASRASPCTNITKQTIGSTTVNHNSTTPLSAATTTCVSTITNTVTTANTIAHRDVVACSLAGRNNNNSPRGHSPNRERDSYSSNVSTLSRSSITPVSVPNTSSPANSSLPAYSKAQGWISSNTTSQLSPATATSVPRPTPPPPQATLGMHSFPPPMFTAPLPPPVSSASPHPSLPTLPPPTTNPIPFSAESLFQSRVSHVTGQTDLLRRELDNRFLASQDRNVPASVANLGPPPYLRTEMHHHQHQHTHVHQHTTPLLPPPATTSLFPPPIFKDIPKLGGVDSPFFRGNLNLSSYSSFNAGLMHPGMAPPTTPFVPPNHMSSFAPKKTGKWNAMHVRIAWEIYHHQQKQQAEAKAGTVVNTKTELLRPPGHLYPGGPGSGLGLGGPPMAPPFPTNMPPTHPGAPPPPHPVGFLTTQGSHLGMLKGPGMSPFGRYPASFGAPNPNFPTLSGYPPPREMSQLSGLTSAVHDPWRGLQRTATGFPPTTAGWSLKPEPPAIDRRAELEEQQQRERERERERERERERERERERQRREREREEQRERERREREKEEKRKQQEAAERERERREKERREMERREMERERIMHQNRQHAVMTSRDRSPLRNGTSMPMDPSEVRVKEEPRSKDDDVVMLSRGPPPGPGPGQGPSPIPDPRYHHSHPHAYLARHPHSLPPNHHAMSRSMMPLGGHHMQHFPPPSGPGGQPGGPWGADPFRDPYRYDPLQQLRYNPLMAAAFRAEEEERAKLYANYSQASVNALRSKDPSPGPLSNLHMHHRAGPGPGVPGRPMEPSLMHGGDIHKKEDTSQSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HPP1</accession>
    <name>A0A8J2HPP1_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Odorant receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HICCMSTLAB_LOCUS10621</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cell membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the insect chemoreceptor superfamily. Heteromeric odorant receptor channel (TC 1.A.69) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5101719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HPP1"/>
    <dbReference type="OrthoDB" id="8119298at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005549">
        <property type="term" value="F:odorant binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004984">
        <property type="term" value="F:olfactory receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004117">
        <property type="entry name" value="7tm6_olfct_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21137">
        <property type="entry name" value="ODORANT RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21137:SF40">
        <property type="entry name" value="ODORANT RECEPTOR 56A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02949">
        <property type="entry name" value="7tm_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 9" id="KW-0552">Olfaction</keyword>
    <keyword evidence="7 9 10" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="8 9" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="79"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="117"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="344"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU351113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAG5101719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="374" mass="43328" checksum="0C5743CDF44220CD" modified="2022-05-25" version="1">MALHMFKNMTNVETISDVVGFLAPLSVTTMKSIKLSTMQKKVDQLIESVYKPVEFLKYSSDIGVLTTIRTAMYYQKFESILFASILSIVTCIIFLVASELSETGLVMPGQFPFDETAPWIFQIIFFMQFWTIFLGCIWVGLFDLLLLGLIRWINVQTSILQSNYKNCEPTEAKRDNFIVSKETFNRIETYDYFKVTEAQYKIKVFIPFEIDELNVDNDSFALRLKSCIKNQKRIVNCINNFNDTFSLTLCIQIITSNAVTCFYLYQAAWAIKHNKSIIKCCIMFFSVTTELFYYCIYGTLLGIQGDALRESQYNSSWNNYLNREVSNLLINAMIMSIRPIEMKAGYFFTFSVQTFISVLQRAYSFFAILNTMMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HQ58</accession>
    <name>A0A8J2HQ58_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Similar to Aldh1a3: Aldehyde dehydrogenase family 1 member A3 (Mus musculus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HICCMSTLAB_LOCUS11029</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5102466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="310895at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000050">
        <property type="entry name" value="Aldehyde dehydrogenase, mitochondrial"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000026">
        <property type="entry name" value="Aldehyde dehydrogenase, putative"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000001">
        <property type="entry name" value="Mitochondrial aldehyde dehydrogenase 2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11699">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="5">
        <location>
            <begin position="19"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="5">
        <location>
            <begin position="299"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="5">
        <location>
            <begin position="709"/>
            <end position="1161"/>
        </location>
    </feature>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="5">
        <location>
            <begin position="1167"/>
            <end position="1462"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="476"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="947"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="1319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAG5102466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="1506" mass="161684" checksum="8EB497883284CFD2" modified="2022-05-25" version="1">MAGGEVSIKYTQLFINNEFVDSESGKKFTSINPADETVVAEVAEARMADVDKAVAAAKKAFARGSAWRSLQPAQRSALLNKLADLVERHVQEIASIMTLENGKPFAHAMGETQIAADTFRYYAGWSDKIQGQTIPTDDGTLVMTRKEPVGVVGQITSWNFPVLLYAIKLGPALAAGCPVVLKPAEQTPLCNLYLAALTKEAGFPPGVVNVIPGFGPTAGAALAEHPDVAKISFTGSVEVGKLIMKASGNSNLAASAKIEIKYTQLFINNEFIDSESGKKFPVINPATEEEIAQVSEGLELADLMERDAQQIGHIQTLENGKPFAHSAGETHMAAGVLRYYAGWCDKIHGQTIPTDDGSLVMTRKEPMGVAGQITPWNYPVMLFALKLGPALATGCTLVLKPAEQTPLCNLYVAALTKEAGFPPGVVNVVPGFGPTAGAALAEHPDVAKVAFTGSVAVGKSIMKASGSSNLKRVTLELGGKSPLIIFDDVDVDEAVKLAHDAIFNFSGQICIAAARTYVHSKIYDEFVEKSKELAVKRILGDPFDPKTEQGPQVEKDMFEKVMGYIKTGDVEGATLVAGGKRHGNCGYFIQPTIFANVTDEMTIAKEEIFGPVQAILKFDKMEEVIERANKTTYGLGAGVLTKDINKALKFAQEIESGTVWVNQYASLMPQTPFGGFKHGAESLDYYLETKTISIKLASYTKLFINNEFVDSVNGRRFASINPVDETVVAKVTEGDKADVDKAVAAAKKAFARGSEWRGLQPAQRSTLLNKLADLVERHVQEIASIMTLENGKPFAHAVGETQMAADTFRYYAGWCDKIQGQTIPIDDGTLVMTRKEPVGVVGQITSWNFPVLLYAIKLGPALAAGCPVVLKPAEQTPLCNLYLAALTKEAGFPPGVVNVIPGFGPTAGAALAEHPDVAKISFTGSVEVGKLIMKASGNSNLKRVTLELGGKSPLVIFDDVNVDEAVKIAHEAIFANSVQVCIAASRTYVHSKIYDEFVEKSKDLALKRKVGNPFVPATEQGPQVEKEIFDRALKFIEIGKKEGAKLVTGGERPTVFVNVTDNMTIAKDEIFGPVQSILKFDTLEEVIERANQTTYGLAAGVLTNDITKAIKFAQAIESGSVWVNHYADTTLQAPFGGYKQSGIGRESGPEALDNYLETKTISIKLASSSVGDIQASAATLRYYAGWCDKIHGNTIPSDGGKFTVTRKEPIGVVGQIIPWNYPILMLAWKWGPALAAGCTIVLKPAEQTPLTALYIGSLVKEAGFPAGVINIIPGYGPTAGAAISEHLDIRKVAFTGSTEVGHIIMAAAAKSNLKHVSLELGGKSPVVIFDDVDIRQAAQIAYNALFDNHGQSCCAGSRTFVHSKIYDQFVKVAKELAMTRKVGDPFNPQTVQGPQIDQEMFDKVLGLIKSGKDEGAVCECGGEREGNVGFFIKPTVFSNVKDGMRIAKEEIFGPVQSILKINCYDAITPQTPFGGYKKSGIGRELGEDGLEGYLETKTISIRVPEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HQ63</accession>
    <name>A0A8J2HQ63_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">alpha-glucosidase</fullName>
            <ecNumber evidence="2">3.2.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HICCMSTLAB_LOCUS12125</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing (1-&gt;4)-linked alpha-D-glucose residues with release of alpha-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.20"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.20" evidence="2"/>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5106167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HQ63"/>
    <dbReference type="OrthoDB" id="1740265at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004558">
        <property type="term" value="F:alpha-1,4-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.400.10">
        <property type="entry name" value="Oligo-1,6-glucosidase, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="GH13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045857">
        <property type="entry name" value="O16G_dom_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10357">
        <property type="entry name" value="ALPHA-AMYLASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10357:SF179">
        <property type="entry name" value="NEUTRAL AND BASIC AMINO ACID TRANSPORT PROTEIN RBAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035169502" description="alpha-glucosidase" evidence="5">
        <location>
            <begin position="22"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="650"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 13 catalytic" evidence="6">
        <location>
            <begin position="38"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="243"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="586"/>
            <end position="608"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAG5106167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="674" mass="76365" checksum="C762E33BC821415E" modified="2022-05-25" version="1">MSAKIILLSSLIFLIIGLCDCNVNSEEPEWWESTQIYQIWTRGFKDSDGDGEGDLQGILSELDYLKDIGVETICLNPIFLSPLIDFGYDISNYTDIDPIYGDLEDFDQLIEEAHEQDIKIILNIVPSHSSIEHEWFEASVNRIAPYSDYYIWANGSVDENGTRVPPNNWASVWNYTKGSAWTWNEDRDQWYYHKFKDTEPNLNLRNKDVVEEILDILDFWLDRGVDGFQISKGGFFYEDLDLEDDSDESNESDDSNESDESVDDFGDDEYANFLYKIREFTDNWTEENNSTSKLLLVESEESDANLISYYGDNNRSGVVPFNFHLITNVTIDDGADDIKILIENWLDDIPENSTTNWPISHPDGSRIATRQGQDRLEAWMVLTMLLPGQAYSYYGDEIGMTDAAEVPGYLKTINPTLNNLADLSKYAAKSPMQWDNSTSAGFSVNETLYFPINEDYVTRNVESQLEDSLSTLNTYKSLAHLRKDPVFHHGNFSIETINNDKVIFLKRHLENHPDYLVLINFGAEEEIVNITSLVSDDEDDDDDDDDNFVVVFSTNEENLYEVNSTVETVVIEPSDAVVLRNYINETDANSPEDDSSQENSDLKPTPYSLGVGVIDSTPANLAVTTEELDDDEEETLDISSEIIPESTASVGGTALIINPIITLLSICCILLLFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HQ85</accession>
    <name>A0A8J2HQ85_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS11230</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5102880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HQ85"/>
    <dbReference type="OrthoDB" id="7554019at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005312">
        <property type="entry name" value="DUF1759"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331:SF4">
        <property type="entry name" value="PEPTIDASE S1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331">
        <property type="entry name" value="PHD-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03564">
        <property type="entry name" value="DUF1759"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="288"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="288"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5102880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="342" mass="38829" checksum="A6EF9930A300A3FF" modified="2022-05-25" version="1">MVDRLTDDELNRLSMTAVEAAQNQGYRLWHEITNLNSLIFEMYPEVLQHEYHTGNRYTTAHASYTTLETRIATRKDAIQEEIDARDAEQAQNTLAMHSTAYMSGSSGTGLPKIKLHTFSGDFKRWGSFSQLFPDIVIDNALLKNSQKMHYLKTFTEKEAHQLIGNMPSTDDSFEPAWNLLKSRYSNPRRVVASHLEDLLVGESVPARSAAKLDALLLSNQKALDSIKAQGVPVNNWDLMIIHLTLRRLPPAVREDWETSLGLTDIMPTYTQLHEFLKSKVRAWENLEPASEPKKQPENHKSGGSRSDKQPRTKSSYTAAHQCDLKHSNVQLSSWNHVFDSVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HQC9</accession>
    <name>A0A8J2HQC9_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Olfactory receptor 112</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HICCMSTLAB_LOCUS13804</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5109168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HQC9"/>
    <dbReference type="OrthoDB" id="7540137at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005549">
        <property type="term" value="F:odorant binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004984">
        <property type="term" value="F:olfactory receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004117">
        <property type="entry name" value="7tm6_olfct_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21137">
        <property type="entry name" value="ODORANT RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21137:SF35">
        <property type="entry name" value="ODORANT RECEPTOR 19A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02949">
        <property type="entry name" value="7tm_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0552">Olfaction</keyword>
    <keyword evidence="8 11" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="9" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="37"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="70"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="130"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="191"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="259"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="292"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAG5109168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="388" mass="44744" checksum="A306B61F63676E37" modified="2022-05-25" version="1" fragment="single">MSQPERSDYVKFRGVTKSFMAICGLWHYETTSLFYRLIPYEQIVLIVTLIMAILKLIYENHSNLLFVVKSLNFATSYVFTCFKVLSFILNKENLKNLQKALDLNFDDMLEDSKISKLILKNISIFKSISLTYAMSVILTTTCYISIPVSIISYASYHKINLTQYPMLYPASYIWKRPAKGLFYQLNFSLEIITAATITAITISIDTMFMLYVFQMIGQLRKISYYVTYTGEKSDQNHALSTYVSQYVNLIKYKDSFEKVYGPIILILLTTNAVVLCTLLFQLTHVCFSTKSIIQGLSYLLYLILKVIQTFMYSWSGSCLTEESEKCQYAVFSANWFGNKKMMSSIVIILSQRPLLLTACNFATVNVPIFILQTSMSYFFLLQTIEEHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HQF1</accession>
    <name>A0A8J2HQF1_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Genetic suppressor element-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS13303</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5108570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="8744624at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022207">
        <property type="entry name" value="GSE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042337">
        <property type="entry name" value="GSE1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17608">
        <property type="entry name" value="GENETIC SUPPRESSOR ELEMENT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17608:SF4">
        <property type="entry name" value="GENETIC SUPPRESSOR ELEMENT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12540">
        <property type="entry name" value="DUF3736"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Genetic suppressor element-like" evidence="2">
        <location>
            <begin position="1016"/>
            <end position="1151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="234"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="404"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="518"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="566"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="650"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="725"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1022"/>
            <end position="1046"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="234"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="254"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="295"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="415"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="440"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="528"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="650"/>
            <end position="659"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5108570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="1354" mass="148627" checksum="EF6623A2DB75F510" modified="2022-05-25" version="1">MNLLTGLQPASTKAQSSTIGKSHRPSSGVLPQGHTPGPGPGPGGQQNSRSFAAALRNLAKQAGPAPQDEEPRASPKNRAPPPLVRGPSPAKERSTHERRPEEIPSMYTNARPAENSKHSVTAAASELLARSGFQPYRPEHHPTQQPPAFTLDPAAYSPYHHSLYPPPHLQHAYRLEEQLYLERVGMLRPPLFPALPSYPLYGLRYSPDMLPPASLGLMSPVMHERLKLEEEHRLRQAREQAALRDEEERRRAARNSASTAPVPSPAATSADTAARKPTIAPQMYNERGERDRPNSRNNSTNNTGNESVISKSHNQSRKEDQSPTLAEASNLSPVYHHQRLAPPYTNPSALATGISTPAICSVSSTPIPPGLPSLSLGPAIPPVPIGPTIPAPLNMPLAPMMGLHLPPPPPNTIHSSQHSNSLMSSPPTTCSSYPIPHQPVPIHQPSQPGALPPQHQQSPSQSQPQHPLSVQHHLNSGFTTTTNSMLASGTMTTHATHTLSTPGASPSINVSNHLSPHVTHSSRLKEVSTPTTTSASASLSTPATTATATTSAPAYQPTFVRPFEDSFRSSSAANKPPSQPWSILNNPNMTSQIHQEPLVNKLPTSTATQALAVPVAPMPIPGNVAANFPQDSTMPVDNSKSSTIYAPLQHHPQQQQQQYHHSHIPPENSGSLYKPQGFPVGSHHSQLPTPQSTPRTTAITTTTTSIMSTNIQTCGSTCSTVSTNTNGTSDTASKPGNLNINGTKLSNNSIGHSDGMNDSVGVQKNGHDKTTTNLNYYSLAENNLTGNPIKHVSLNVNNRNVLEHTKENKVQVHVKVSNDISNALHPKLMPNRVNNVNPDIKSQYPAVGNETAKERMSPVFIKSAESIGDKNGNKYNNENLTGKMPLEIPSVLPPSIQAISYPAPLKYPNEIVNSKDSFNSGNFMQSIKSKEVLRTCQNVSNVLLQIPKYQEMLINYSTELKGTYCYTDKCNNLAEITVKCEPPVINVPDPAKVLGKVEDCVAGEEALTLVVGKPKEVTSTLDLAEKRRKRKREQNSGISYSSESESEDDMAKDVDLWITKGPPAKMCYSEKKLSFLAIFGLTTLSMRNEIELHKLEKRYRLNPEPPEIPVDTNETTCKVESLLPIPKEHPDVLINSSDFMPKVGFLKTIGLDVMPPSKRDEAEVIWQYVLRDRKKRKSTNCVTVYCDRIAQEYEKNPPKAPQKMRLLDRVKVKPPSGRAPLLPPLPGLFSAYYPAVPVPIENGVNQLYQFPMKQRTWAEEENEESEETKKAIWTNIEDIMTAYYQYSKDKSTERKILTEEMSKLVARANMLCSEQKQLEQARDELLATKSSLEFERRSISDQIKRIKTLVKRLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HR73</accession>
    <name>A0A8J2HR73_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Odorant receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HICCMSTLAB_LOCUS13790</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Cell membrane</location>
            <topology evidence="1 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the insect chemoreceptor superfamily. Heteromeric odorant receptor channel (TC 1.A.69) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5109154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HR73"/>
    <dbReference type="OrthoDB" id="8185860at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005549">
        <property type="term" value="F:odorant binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004984">
        <property type="term" value="F:olfactory receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004117">
        <property type="entry name" value="7tm6_olfct_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21137">
        <property type="entry name" value="ODORANT RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21137:SF35">
        <property type="entry name" value="ODORANT RECEPTOR 19A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02949">
        <property type="entry name" value="7tm_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 10" id="KW-0552">Olfaction</keyword>
    <keyword evidence="8 10 11" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="9 10" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="70"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="130"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="192"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="267"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="293"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU351113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAG5109154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="391" mass="44768" checksum="AF52BABA0E05D7EF" modified="2022-05-25" version="1">MSKSKLAEYIAYENLIRLLLSTIGLWSPEESSLFCRSIIYLQMSTCILPFIGVFNFFRTNFTNVSLATKSFSLLASYLTVIVKGFAIVLNRKDVKDLRKMLVSHYNNLIRDPKMTNIVLDQITTFRRLSYVAIFFVVVACMSYIIIPIIFIISQLIRGADHIKYILPFPTIYNWEIPPNGFRYRVHFLTESFAIFSIILITIAVDNLYSLHVFQIIGFLREISYRMKHFHEDNDDKGSSDLVVRRCVFQYGILIASCRKLQRIYGPIILWTMGTNAVILCAVTFQLSQMSSISIGRIILFTAYAGVKLIQVFIYAWAGTRLTAESEDCRAAYYAANWVGNKSFMRNIIIMLAQKPLILTACNYSIVSVEMFGSVLNTTASYFLLLNTFDEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HRY2</accession>
    <name>A0A8J2HRY2_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS12167</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5106252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HRY2"/>
    <dbReference type="OrthoDB" id="8195120at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="135"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5106252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="166" mass="18299" checksum="CA2B11469E0D353E" modified="2022-05-25" version="1">MVYGLLLSGSIGMLTTSETQPSTLVATMTDPNYKNWHIPRPSLVIGRVGDKESGDEYSVHNWVQHHHYNNLNSNSDSNAPSAANLAAIQPPTLVPQKQKSADAVSVASSTHFTVVNGLGRSVVMYKKSWCARHQLTVLVCTMSFLFMVGLLAGVLYMEMRVRDKYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HS87</accession>
    <name>A0A8J2HS87_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to PRC1: Protein regulator of cytokinesis 1 (Homo sapiens)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS12376</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5106671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HS87"/>
    <dbReference type="OrthoDB" id="642895at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990023">
        <property type="term" value="C:mitotic spindle midzone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051256">
        <property type="term" value="P:mitotic spindle midzone assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1520">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007145">
        <property type="entry name" value="MAP65_Ase1_PRC1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19321:SF41">
        <property type="entry name" value="FASCETTO-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19321">
        <property type="entry name" value="PROTEIN REGULATOR OF CYTOKINESIS 1 PRC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03999">
        <property type="entry name" value="MAP65_ASE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="457"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="518"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="602"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="218"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="468"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="641"/>
            <end position="655"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5106671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="663" mass="77956" checksum="1B8E83E67B7BBCB8" modified="2022-05-25" version="1">MSDLITKKELLEKLCKKIQVKIPELFKIWRQCGYDERMISEYSKNVDDHIEDLLVDMISEAESRKCAIIREIKIISKKIKAMEVELDIDESDRDNPPTEPLIEVVASLQRKLKHLEEIKDKRISQADKLIERETKVCEALGVQRLGLVKNVPSEEELMQFESKLAKQEAELIAHKTTFKETRLAIMAMMNEMSHVPTHEFENLVCVDYENFIFSTSNMRKLRELHSDIEEQLRAAKEDAKNKRQELIKLWKFLDIPEKKCREFLAVHSGYDIPTLNALQKEIKRMQELRLENISKFIVKLREDLQHWWEVCKLSQEERDEFRFFNSQIYTEDMLKIHEIELERLRHHYEENKKIFDLLEKWEETWGQMKEIQRRSEDPDRFHNRGGQLLADEKIRKACNKNLPKLVNQLKEMTDEYEKKHRKLFRVYGLTIDQYIEQEYENQKVELEKLKVETAKAKDEKNNLKKTPLSASRRTPRTGLSVSRRTPGVLSTSRRTPVSAKNLRSNTSIKRKLSDHSPFTRVTKPRMTSNSENVRPAKVARKLISDNSNKSMGKSPRKSPRRNLTTTNKVINIGDSTNSMDKYEQFQEHLEQREDLRSTLLMETSEPRKVKRQPATPIKPSRKHSPNTPAVTPGNRDLATKLTSTPRTPRLTPAPSMRNMENNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HTA6</accession>
    <name>A0A8J2HTA6_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS12981</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5107925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HTA6"/>
    <dbReference type="OrthoDB" id="10504461at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035324335" evidence="2">
        <location>
            <begin position="19"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="160"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="174"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="197"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="223"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5107925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="270" mass="30715" checksum="FFB80DAE4F38CE81" modified="2022-05-25" version="1">MRIAVLATLVLCVIIVLSLESIDGKKTHGKNKHSDVEHHSTRNGKKNKVEKNHVKTKERKRRSAEDMDVDEKMIVEETVQKHKKTQKNKQRKENAGSDEILNEVKEKKKRVESNKTKENRNQQEDEDVDTVTDNEVDNQSNDLETSDKTDAENSQSVETGAKESSDKIKNGKPDKKKKDKIKKKIKKDKKLKKSSLSEDENIIDEQDEQECDSHCHFNAGKNKKSEKCKSKYSDGKSTKSKISKCTSSNSDDISVDAENETVGNEEEKNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MC88</accession>
    <name>A0A8J2MC88_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS3060</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001117">
        <property type="protein sequence ID" value="CAG5079634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MC88"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5079634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="76" mass="9220" checksum="D91EB87639FDF6F8" modified="2022-05-25" version="1">MLQPMHHSKRRYWEIGLAAPSLEFKANDGPRKEGRDEECDMCLIFLLPRFRLAACGHIYYKEYFWNFLRLKSDDFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MFK7</accession>
    <name>A0A8J2MFK7_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Similar to Adarb1: Double-stranded RNA-specific editase 1 (Mus musculus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HICCMSTLAB_LOCUS4806</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5088341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MFK7"/>
    <dbReference type="OrthoDB" id="6363432at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016442">
        <property type="term" value="C:RISC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070578">
        <property type="term" value="C:RISC-loading complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035197">
        <property type="term" value="F:siRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070920">
        <property type="term" value="P:regulation of regulatory ncRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030422">
        <property type="term" value="P:siRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014720">
        <property type="entry name" value="dsRBD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051247">
        <property type="entry name" value="RLC_Component"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46205">
        <property type="entry name" value="LOQUACIOUS, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46205:SF3">
        <property type="entry name" value="LOQUACIOUS, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00035">
        <property type="entry name" value="dsrm"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00358">
        <property type="entry name" value="DSRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54768">
        <property type="entry name" value="dsRNA-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50137">
        <property type="entry name" value="DS_RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="DRBM" evidence="4">
        <location>
            <begin position="196"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="DRBM" evidence="4">
        <location>
            <begin position="390"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="276"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="439"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="8"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="28"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="67"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="146"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="283"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="449"/>
            <end position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAG5088341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="459" mass="50938" checksum="9C760D5BFFF9187E" modified="2022-05-25" version="1">MFTRSRGPGNQTPNQSKQNYGAGRGTMLNPSYSAQNNTYIQQGNYQQNAAQKTPGNSTNQQFKGAAPQQQQQQQQQQPQQQQQLRQQQQQQQQPQQQQPNVQPGQNQANQQQVSQPQRLKPILKQTPQPAPAAPVAPVQIPALGDPETENNEMNDEPMPQQTADQPKWKRIKVPGVKVNRKLKRLRMNQRLRKTLMPKNAIMVLNEMKAGVKFHLVENNTVPTSMFLVHAELEGKTYVGQGLSKPLARQNAAENALKSLLLEKMNAAAKKIKFDDATDGKESVASSQEIQNDEQPPADDSSVSGVTPMEISGNEESDDIPWSSLASFALYKLFVEWQNQGSVVPIPRPGLQQPVKTKSEPKPSLEKKLPANAETIHPVMLLNQMRPGTVYTEINRRGNPPNTYFTLAVDIDGTSYSGEAKNKKDAKKAAAKAALKGLFGLEYPTETEESNQTLIQDTPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MHC6</accession>
    <name>A0A8J2MHC6_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS3714</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5083038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MHC6"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5083038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="88" mass="10169" checksum="EA37E87A9610061D" modified="2022-05-25" version="1" fragment="single">MCRQNRRKKNENKIKIKKNPGKSSTERSREFRARKKQLLNNQNRCSNISVNVTGVINDRSQQQNSVPTGHNLVNNDYNPPVDVQPEIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MHD1</accession>
    <name>A0A8J2MHD1_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS5380</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5089799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MHD1"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5089799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="151" mass="16808" checksum="110F4FBF43D8AC01" modified="2022-05-25" version="1" fragment="single">MSEKTRHFRSWTRTGLGSGERNVLVPDHDFKLLSADSVRLGPERVVFLHYFGVLDDSFELLHHALMHVSFLPDHRVVLVIRVVGIAELAIRTELKLEELVPELSLVSDVKMFAGWLTGVNLCNAITVFGGDNNKNLSTLEDTLTPCGGNIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MHH8</accession>
    <name>A0A8J2MHH8_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="18">Similar to Klp61F: Kinesin-like protein Klp61F (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">HICCMSTLAB_LOCUS3822</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Spindle pole</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. KIN-5/BimC subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5083379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MHH8"/>
    <dbReference type="OrthoDB" id="3176171at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072686">
        <property type="term" value="C:mitotic spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005876">
        <property type="term" value="C:spindle microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000922">
        <property type="term" value="C:spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008574">
        <property type="term" value="F:plus-end-directed microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090307">
        <property type="term" value="P:mitotic spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051231">
        <property type="term" value="P:spindle elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01364">
        <property type="entry name" value="KISc_BimC_Eg5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000035">
        <property type="entry name" value="Kinesin-like protein KIF11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047149">
        <property type="entry name" value="KIF11-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047241">
        <property type="entry name" value="KIF11-like_kin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025901">
        <property type="entry name" value="Kinesin-assoc_MT-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47970:SF12">
        <property type="entry name" value="KINESIN FAMILY MEMBER 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47970">
        <property type="entry name" value="KINESIN-LIKE PROTEIN KIF11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13931">
        <property type="entry name" value="Microtub_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="9 15" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5" id="KW-0493">Microtubule</keyword>
    <keyword evidence="7" id="KW-0498">Mitosis</keyword>
    <keyword evidence="10 14" id="KW-0505">Motor protein</keyword>
    <keyword evidence="6 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="17">
        <location>
            <begin position="15"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="941"/>
            <end position="989"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1014"/>
            <end position="1066"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="367"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="945"/>
            <end position="961"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="1014"/>
            <end position="1023"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="1034"/>
            <end position="1045"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="99"/>
            <end position="106"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00034704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="CAG5083379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="1066" mass="121170" checksum="AD56A2538EE864BD" modified="2022-05-25" version="1">MSELSNRSKKDKNQHIQVFVRVRPSNQSESCGKSFTVIDVPSYKEVLVRERPQDKVSKKFTFDRVFGPKSKQLDVYTAVVNPFVAEVLAGYNCTVFAYGQTGTGKTYTMEGAGSDPAASWQTNSDAGIIPRALSNLFDDLRLGTQEYTVKVSFLELYNEELFDLLSSHEDASKLKLFEDSTKKGSVIIQGLEEVIVHNKDEVYKILQRGSEKRQTAATLMNASSSRSHTVFSITVHMKECSVEGEELIKTGKLNLVDLAGSENVGRSGAVDKRAREAGNINQSLLTLGRVITALVERGPHIPYRESKLTRLLQDSLGGRTKTSIIATISPSSLNLEETLSTLDYAHRAKNITNRPEINQKLTKATLIKEYTEEIERLKRDLLATRERNGVYLSSEDYDRLVANNTSQGKEIEEKIQFIKVLQEELENKSKLFEKVSYKLEKTSLKVKIIKQDRDEQKYLVDNLEKIKESLSSQAQTLLQVADTATDHTNRLHDKIARKNKVEDLNDQLCKSFVSRISESLKELITDVNKYSSEVIKESKGVKELISERSDGCKKNLEGFVEKREKDLEKSEGNLKEFEEVTCANAANYKSLFENIVISTREIDEEEKKKLINVSEHFANEIKRLVNNQIAENLASVEKDLQNKLRCLRQHLQVTVTDLYLTMNEKMNLVGSKLANLEEQIKIREDCNVVNKNKEEKFDELMKEMMDNYLELRKGIRSEREKDSEVTKVWLGELEIVKGEVKEVCEKHEGLKSFVDSEVTNNVKGIQEVIGESVKVNCGIAKETISSGEKLAEKFKSLLGDASQIVSDYREKVEEKMVKAAELVEKDKNGLKEKVGGFKEVLGRDLKEDCGLIEEYAEEVLEMSREVGRSVEEVERKVGGQKEGLVGNVEKIEGSLKRFFEDEVKKDTPTGATPVKKDFEYPRKIVEMSPRERIVEKFRKWREEHPEDEEEEEEEEDNEELDVTLASNLNETEVVPPTPVQRSRSRSVDKVKEAGTKLFTARSEQQINLELSDFQRSSLTSGENSSDEFICNNKENGKKRSGDKRISKQPKFVPRKYSKKVLTSHND</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MHU5</accession>
    <name>A0A8J2MHU5_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Similar to clasp1-a: CLIP-associating protein 1-A (Xenopus laevis)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HICCMSTLAB_LOCUS6437</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5092918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="46159at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045180">
        <property type="term" value="C:basal cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005881">
        <property type="term" value="C:cytoplasmic microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005815">
        <property type="term" value="C:microtubule organizing center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072686">
        <property type="term" value="C:mitotic spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005876">
        <property type="term" value="C:spindle microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040001">
        <property type="term" value="P:establishment of mitotic spindle localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090307">
        <property type="term" value="P:mitotic spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031110">
        <property type="term" value="P:regulation of microtubule polymerization or depolymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902903">
        <property type="term" value="P:regulation of supramolecular fiber organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000225">
        <property type="entry name" value="Armadillo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024395">
        <property type="entry name" value="CLASP_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021133">
        <property type="entry name" value="HEAT_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034085">
        <property type="entry name" value="TOG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21567">
        <property type="entry name" value="CLASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21567:SF9">
        <property type="entry name" value="CLIP-ASSOCIATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12348">
        <property type="entry name" value="CLASP_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01349">
        <property type="entry name" value="TOG"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50176">
        <property type="entry name" value="ARM_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50077">
        <property type="entry name" value="HEAT_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="TOG" evidence="8">
        <location>
            <begin position="2"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="6">
        <location>
            <begin position="166"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="5">
        <location>
            <begin position="167"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="TOG" evidence="8">
        <location>
            <begin position="311"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="domain" description="TOG" evidence="8">
        <location>
            <begin position="777"/>
            <end position="1026"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="552"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="655"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="775"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1018"/>
            <end position="1038"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1102"/>
            <end position="1128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="552"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="566"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="672"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1021"/>
            <end position="1030"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1102"/>
            <end position="1122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAG5092918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="1419" mass="158268" checksum="8D7B46AB9193D799" modified="2022-05-25" version="1">MTFNPRDMDGFMPLLSTSDIKTKMLIGNNLLTYLGDLNNSIECQDIGLFIDNVIPWLNNGNAKIVQNGLEILTQIADRMGHDFKPYISSIIQPTIDRLGDSKDLTREKARLVLLKILEKGSMIPQSLLDRIHPTFIHKNAKLREESLLLLTTILAEHGADSLSLSSVIPSIVKLLSDPNEKVRETAVNTVVNIYRHVGERFRNDLQRNHNLPSAKWQLLVEKFDHIRAEGDLFPHANAMDVGRDTDELDRVVRSAPAKKIKSVLPKKSQFGPSVKIPSIGSKLNDRTNSGNAGAVDEESFSNAFEDVPQVHLFSAKDLEEHFKTIRDIIGDDKKDWNQRIDHLKKIRGLVMAGGASYENFMELLKSIQNPFEGACTDLRSQVVKEATITLAYLSRQLKNKIAQFVEGLLGPVMNLIQNSAKVVSSSGAVALRFIFQHTHSARFIPILTAFFTSKSKDIRRAACEYVNLILQTWSTSLLQKHIKILQDAIGKGIGDPDAEARSHARKAFWAFRDHFPDQAEMLLNTMDASHKRNLLSQSNSGSVNSLNAVVRTPSIPPRSTRPTMSAAGSTENLHQTQSPPYGPLKRTPSLPRSYRQSGIPVLQRPTDNYCRVSPGPRSNSAIDLQAARRAQSRLKYASINRTKATTVRPVAKQVETNLFTSPERSARTKTRVSGVSQSQPSSRSCSPASRMSYASYSREGDSFIARPRRLSGQGMRSTETSRDPSPQRFGLDRSVSSKLRERNLYMSPRPPVMAQKMLQQSQAAESALADALTFDRDHHPKTPNRNKGDQSDDSETSKIIEWCGRKQWGERKEGLMDLQQFLINGNTLTATELRQITDIFTKMFMDSHTKVFSLFLDTLNELIITHSEDLVDWLYVLCTRLLNKLGMDLLVSIQTKINRSLDVVKENFPSEQLLPVVMRFLTDPAHTPNSRVKVATLTFLTHIADNAEPSSLTPSCKSALVRLLDWTSDMKSQEVRRHASEAIIALYNLNPPLFPMLLNELPKMYQDTAMPLIQNHLKRSPASNPASPSGQLPRVPQSPARTVIRHDLESDDHLNPEEVYKSLRRTTAEIQNYGFERMEGATSSKDSGISNMADVEEKIESLTLSNSGRSSSVSSPTQRGRSVGSITVNGSSDTIAGDLILPDRRNNGYETHNVAGVSPELPRGPEVFERTLRLLQSSETQTLDKANVLRDFQIYIRDGDGAKYVITQFKKLLKTMLDCLALDDKSLEIEVLKTLIEMLKCRDLTNYFDDFADLLILKVLNEHKSDAYEGSSSSPRRGNSSAHCAKPLQLLKAAEDCAAMIAAVLPPHKTIHLALTTAKTEPFPKNVAAIKMIQNVVEHRGKDALGALIDDVMGTLMQAYENPESVVRKAAVFCMVAIHAAIGEESFNKYRKNLYGAQEAVQASSSPRTSGRCIFQFHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MJR0</accession>
    <name>A0A8J2MJR0_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Similar to CST9: Chromosome stability protein 9 (Saccharomyces cerevisiae (Strain ATCC 204508 / S288c))</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HICCMSTLAB_LOCUS7968</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5095958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MJR0"/>
    <dbReference type="OrthoDB" id="2535391at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000795">
        <property type="term" value="C:synaptonemal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019789">
        <property type="term" value="F:SUMO transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007129">
        <property type="term" value="P:homologous chromosome pairing at meiosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016925">
        <property type="term" value="P:protein sumoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042123">
        <property type="entry name" value="Zip3/RNF212-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22663">
        <property type="entry name" value="RING FINGER PROTEIN NARYA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22663:SF17">
        <property type="entry name" value="RING FINGER PROTEIN NARYA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14634">
        <property type="entry name" value="zf-RING_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0469">Meiosis</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="9"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAG5095958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="259" mass="29780" checksum="DDEC1A53D6664FB8" modified="2022-05-25" version="1">MSFINHLICNKCYYNKRSGNRPFYLTQCGHIFCHQCISTGTSTCQWCQTPDVQTVELTEPLPPAIVYLFTPRHEFLQNMANVANFQFNQMMISEKLLEQQAEKYNTLKRMFWEQRKTILKIQQMKQKLTTSINELLATQQSHYQPATNSATSDGRYIQPESFFRQDNAVSSNLGHVTQNQRPKYPFGRKVAFVNPSNPYNTVSPCDTYSPLTNINTPRSMNTPITPDTVLYRANYRRAHRSDGGSTTTFSNISSGINLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MKB5</accession>
    <name>A0A8J2MKB5_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Polypeptide N-acetylgalactosaminyltransferase</fullName>
            <ecNumber evidence="17">2.4.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Protein-UDP acetylgalactosaminyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">HICCMSTLAB_LOCUS3431</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 17">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 17">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 17">Golgi apparatus membrane</location>
            <topology evidence="2 17">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 17">Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="17"/>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5081996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MKB5"/>
    <dbReference type="OrthoDB" id="6072411at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004653">
        <property type="term" value="F:polypeptide N-acetylgalactosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006493">
        <property type="term" value="P:protein O-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd23437">
        <property type="entry name" value="beta-trefoil_Ricin_GALNT7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02510">
        <property type="entry name" value="pp-GalNAc-T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.80.10.50:FF:000019">
        <property type="entry name" value="Polypeptide N-acetylgalactosaminyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000053">
        <property type="entry name" value="Polypeptide N-acetylgalactosaminyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045885">
        <property type="entry name" value="GalNAc-T"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000772">
        <property type="entry name" value="Ricin_B_lectin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11675">
        <property type="entry name" value="N-ACETYLGALACTOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11675:SF68">
        <property type="entry name" value="N-ACETYLGALACTOSAMINYLTRANSFERASE 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00652">
        <property type="entry name" value="Ricin_B_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00458">
        <property type="entry name" value="RICIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="Ricin B-like lectins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50231">
        <property type="entry name" value="RICIN_B_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14 17" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="15" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 17" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="12 17" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 17" id="KW-0430">Lectin</keyword>
    <keyword evidence="16 17" id="KW-0464">Manganese</keyword>
    <keyword evidence="13 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="6 17" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="domain" description="Ricin B lectin" evidence="19">
        <location>
            <begin position="445"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="49"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="65"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU361242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="SMART" id="SM00458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="CAG5081996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="568" mass="65809" checksum="533AC1085AC5593E" modified="2022-05-25" version="1">MRVIQLRRNARLITVVILGLLMFYATYSIMNDDYGRSLNVPVLVEGPGNFEPQNLEQRSGPGEGGKPHVLRDDQQNDVQQSESDYGMNMVCSDEISLDRSIPDLRPEECKHWDYPKKLPSTSVIIVFHNEGWSVLMRTVHSVINRTPPEFLEEILLVDDYSDKENLKGELEAYIDKWNGKVRLLRNEERQGLIRTRSRGAREARGDVIVFLDAHCEVNINWLPPLLAPIAVDRTVMTVPIIDGVDHKTFEYRAVYQEGHLYRGIFEWGMLYKENELPRRESKRREYSSMPYRSPTHAGGLFAINRKYFLSLGGYDEGLLVWGGENFELSFKIWQCGGSILWVPCSHVGHVYRGFMPYSFGKLADKKKGPLITINYKRVIETWFDEKYKEFFYTREPLARLLDHGDITEQLKFKERKKCKSFQWYMDNIAYDVLDKFPELPPNIHWGELRNVATTACLDTMGHSPPSLMATSHCHGFGNNQLIRLNSQGQMGVGERCVEADNQGIKLSFCRLGTVDGPWEYDEKTKSLLHKVHKKCIALHPQTNHLSLMPCDYENTYNQWTFHPIHPRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MMC6</accession>
    <name>A0A8J2MMC6_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS6744</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5093315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MMC6"/>
    <dbReference type="OrthoDB" id="7698488at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5093315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="336" mass="37995" checksum="0AE3B4E1F1A1C9BB" modified="2022-05-25" version="1" fragment="single">VQREILSIIKSKKATTETPLTRLEFPTPLLKKLAEELSIRFGGRAEVYYSAGVSEGVNKINPTGKLQNQVSYVRKQLYEAGLLITSGRQRSTSVETTSTTKTSEANLKVLTNKNFTDWDAIKNAWKDTYSCKQQLRADKQDKLIEFSFFPCLANAAAVNLINDDFTSTFQNLTPLSDSWAQIRPALEEFVLSKRIDNINYSGSIHELFQLPDANKDALILELLLDAIKSTTLNSSKRRKIDETQPIDDKKKGYYGSEDNLDSEIKRRTDLITSPTEALDLAFKIFAITNCPFSKASWNVWLLIKKVVYKISSKEKSSVPLQKAITFIEQHLNLKIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MMY9</accession>
    <name>A0A8J2MMY9_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to AGPAT3: 1-acyl-sn-glycerol-3-phosphate acyltransferase gamma (Homo sapiens)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS9179</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5099677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MMY9"/>
    <dbReference type="OrthoDB" id="189226at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003841">
        <property type="term" value="F:1-acylglycerol-3-phosphate O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07990">
        <property type="entry name" value="LPLAT_LCLAT1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10983">
        <property type="entry name" value="1-ACYLGLYCEROL-3-PHOSPHATE ACYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10983:SF24">
        <property type="entry name" value="1-ACYLGLYCEROL-3-PHOSPHATE O-ACYLTRANSFERASE 3, ISOFORM E-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69593">
        <property type="entry name" value="Glycerol-3-phosphate (1)-acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="259"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="284"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="domain" description="Phospholipid/glycerol acyltransferase" evidence="2">
        <location>
            <begin position="92"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5099677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="330" mass="38282" checksum="657DA7DA26271805" modified="2022-05-25" version="1">MGVLESLKKSSFVHLLFAITFFTSGIIINILQSILYLGLKPFSKYYYRKINYYLCYSFYCQLVFMAEWWSGTELTIYIDKNDFDKYYGKEHGYLLMNHSYEIDWLIGWMFCDRIKMLGNCKAYAKKSIQYIPTLGWAWKFAESVFLERSWDKDKETIGQQISELGDYPDTMWLLLYAEGTRFTAEKLELSQKFAKEKGLPILKHHLTPRTKGFTASIPHLRGKVDALYDIQLAFNPKAAIKPTMTNLLRGEKVEAHIRYYSLLNTIFWALIVLVPMLYYLVKLFISGSTIAFTFGVGIIVLFFLLMYKTIGMSEISKSSSYGAATSKKTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MN17</accession>
    <name>A0A8J2MN17_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Similar to BRD2: Bromodomain-containing protein 2 (Canis lupus familiaris)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HICCMSTLAB_LOCUS8516</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5097049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="21449at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05497">
        <property type="entry name" value="Bromo_Brdt_I_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05498">
        <property type="entry name" value="Bromo_Brdt_II_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22249">
        <property type="entry name" value="UDM1_RNF168_RNF169-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.920.10:FF:000003">
        <property type="entry name" value="Bromodomain-containing protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.220:FF:000001">
        <property type="entry name" value="bromodomain-containing protein 2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.920.10:FF:000002">
        <property type="entry name" value="Bromodomain-containing protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031354">
        <property type="entry name" value="BRD4_CDT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043508">
        <property type="entry name" value="Bromo_Brdt_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043509">
        <property type="entry name" value="Bromo_Brdt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050935">
        <property type="entry name" value="Bromo_chromatin_reader"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018359">
        <property type="entry name" value="Bromodomain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027353">
        <property type="entry name" value="NET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038336">
        <property type="entry name" value="NET_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22880:SF225">
        <property type="entry name" value="BROMODOMAIN-CONTAINING PROTEIN BET-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22880">
        <property type="entry name" value="FALZ-RELATED BROMODOMAIN-CONTAINING PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17035">
        <property type="entry name" value="BET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17105">
        <property type="entry name" value="BRD4_CDT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00503">
        <property type="entry name" value="BROMODOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00297">
        <property type="entry name" value="BROMO"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00633">
        <property type="entry name" value="BROMODOMAIN_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51525">
        <property type="entry name" value="NET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Bromo" evidence="5">
        <location>
            <begin position="125"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="domain" description="Bromo" evidence="5">
        <location>
            <begin position="469"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="domain" description="NET" evidence="6">
        <location>
            <begin position="768"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="60"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="219"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="345"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="564"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="616"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="707"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="847"/>
            <end position="964"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1025"/>
            <end position="1087"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1373"/>
            <end position="1397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1426"/>
            <end position="1531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="88"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="243"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="349"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="572"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="616"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="708"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="742"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="854"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="903"/>
            <end position="943"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="955"/>
            <end position="964"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1025"/>
            <end position="1037"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="1052"/>
            <end position="1075"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1373"/>
            <end position="1387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1426"/>
            <end position="1451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1454"/>
            <end position="1466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1479"/>
            <end position="1490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1491"/>
            <end position="1511"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAG5097049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="1531" mass="166000" checksum="EA9BC9789A94DC0A" modified="2022-05-25" version="1">MKPRSIKHQHKTVTCHVAFMYHLCRKDFFCFRNQVNMQQVDTNSQNNSLDVEERERLCNIPKTSAPGRTPGSQPLPARTPPPREEPAVEPVNGVVQPPVVPPPTRPGRITNQLQFLSKGVLKPVWKHTFAWPFQQPVDAKKLNLPDYHKIIKEPMDLGTIKKRLENTYYWSARECIQDFNTMFTNCYVYNKPGEDVVVMAQALEKLFLTKVAQMPREEVELEPPLPKGPKGKKARVGAPLIGGTPGVTPGVGRGRPSSGAATVSSSVPNNLPPAATTAGTTGVLPIPPLGTQAPVSVPGSTNTTTIAPPASISVTSMATHNSLPQQVVPPPSGYHAQPALDPQAATAVPAPPQVPTAPTVMPPSQPAKVKKGVKRKADTTTPTANSFEPMYQPMESKNAKLPTRRESGRQIKKPSRQAEDGLVPFHQANMPLIGVMAQQPQHVGGKSKEKLSDALKSCNEILKELFSKRHSGYAWPFYKPVDAELLGLHDYHDIIKKPMDLGTVKTKMDSREYKTAQEFACDVRLIFTNCYKYNPPDHDVVAMARKLQDVFEMRYAKIPDEPVGGMAAVTHSSSSGSSSGSESSSGSEDSEEERTQKLLALQQELKAMQEKIKKVVEESGKKKSKKSKLEKPKSKPMSNKTPGLVGSHSGAMKELMKPSVGMQNVSDSVGASIASVAMGAGDLKMPSGLPVGVGMGLPGDHHPALAVGPNKAHPGAAAAATVKPKGKTRGPGKSAATNAASKRPKTNSRSTSNKKKNAANQPPPMPFDSEDEDNAKPMSYDEKRQLSLDINKLPGDKLGRVVHIIQSREPSLRDSNPDEIEIDFETLKPSTLRELESYVASCLRKKIHKKVSGKSKDEQMAERKQELEKRLQDVTGQLGNVKKATKKEDNSKSVDVVGSAGTSGPSRLSASSSSSSDSDSSSSSLSSSSSDSSDSEAGNSSNRPPRKKTKKTANAAPSSNLNITQQLSSVNHTGNLLMNNQPPNSTGPVTKPIVTQPNAMPIDHGGNQPAVGGVTTVTGSQGMAISSHTSMPAQPSRPTALATAAPMKKKTTPPPSTPSNPPTPSVSVPTPPPSVTPTNANASITSPMISQATTIPSYPIMSTISAINDTTINQPDLMQPFNPLGSITTTQPSIEMNLSSMKKETTHASMVQNIHQPVSTNNTNANLMTNFKSSVNMMPTNIQSNLLNNIGMGNINLNLQQNLGPALLQNQLENMMNTTQLNNIQNAHNMVMNNQQHSNGFSNIKRETSPSMMNNNGIPNLNMPLGISTVGSIFDPVPPMVSMPMQIPQLTVKKDERPQMTQAPTSHKPMDAGAFFAEMNSLGMPVMSNHSNAQILPEKKMTPPDSKNSAANFASAFKNKTVEQNVKNASSWSSLAQASSPQSAAGSNIKRDSSRDSFLSFKKQAKEKQDRQRALLEQQEIRRQQKEQERLRQESERKREREDEDALEKVMKTVNEQQGVTITPTSRVEEIKVSTETDSSSPSHSSSQDRAAAERERQRLREQDRRRREANANKIDMNMQSDLMAAFEETL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MN59</accession>
    <name>A0A8J2MN59_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Similar to Prdm9: Histone-lysine N-methyltransferase PRDM9 (Rattus norvegicus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HICCMSTLAB_LOCUS8619</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5097261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MN59"/>
    <dbReference type="OrthoDB" id="6077919at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048598">
        <property type="term" value="P:embryonic morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001397">
        <property type="entry name" value="Datilografo, isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000100">
        <property type="entry name" value="Zinc finger 45-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000446">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000624">
        <property type="entry name" value="zinc finger protein 697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1800.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050589">
        <property type="entry name" value="Ikaros_C2H2-ZF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012934">
        <property type="entry name" value="Znf_AD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24404:SF114">
        <property type="entry name" value="KLUMPFUSS, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24404">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07776">
        <property type="entry name" value="zf-AD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00868">
        <property type="entry name" value="zf-AD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51915">
        <property type="entry name" value="ZAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 9" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="ZAD" evidence="12">
        <location>
            <begin position="13"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="183"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="211"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="239"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="267"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="296"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="324"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="352"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="380"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="93"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="434"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="524"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="624"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="767"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="863"/>
            <end position="984"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="126"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="455"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="498"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="539"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="552"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="625"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="863"/>
            <end position="876"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="886"/>
            <end position="917"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="942"/>
            <end position="972"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="975"/>
            <end position="984"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="15"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="18"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="64"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="67"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAG5097261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="984" mass="112846" checksum="57DCA6860D98B58E" modified="2022-05-25" version="1">MENRTTTTLRSRRVCRFCLCENEPLHFIYERDPTRPFQVPLSLQIMSCVSIEVYAADGMPQMICKVCRWNLDRSYKFKLQCKKADDALRAYPATGVLPRPFPPITNDSMDASNKRSAEQRSQSEQVTKKPRVDNGDRDRERRERQESTKSDREEIYKEEHSEADEESMDDKSSKLEPGEIRVHACDQCDRTFPLRQALVLHIQRAHRDRTHKCTECDRMFFSKYDLQKHMSTHAEEKPYSCSICQKTFTRANLLARHEKIHHEDMRYSCQHCDREFFTREDLEKHEDTSHKSIKPFSCNICSKRFTYKQSLERHEMQHSEDKSFTCEYCKEAFRTSTKLARHLQTHAGHRPYLCKLCPRDFLLSHHLSRHMRTHSVEKRHICEECGKAFKRKESLEVHQLTHSKRTGLGLTCDVCQESCRNRADYVTHIKQHIEAGEKMGPDGLSPEIKEKLESESEEEEEEEQFSDGDDDYEPPASLLKKYPKQVPKQSEESEEEPDQRVVKEEPKEQVVFVRAKDGQIVKKTIKTMLPTQRKETPEAKVVAKSPAPKAHQKIESSPKGKDETEAEVQKIVASVFQEHKVALKASTPQEPAKVRSQVIKEEKIEGTPKTVTQVTKRIVVRKPAAETPTAAPATPVKEDVKPATPAVKSTKRVIVRKIIRKGNTEHVEWRYQDGTEIDSADLAKLTTGQVVKRVVKTITKPKVTQAVKVAEQRAPVEAPKFELKTSQASATITPIPAPDNKNDKISEKVEQLEKTVAQQRLQIEELRSRKDSYEPADDMMPDRHDSEDEQELPLKRVFVKTNQSIYDEEKTYDADEKATIKKVEKKEKEKKVFIKTEEPSEVEQMSIEINSMIAEDKKAAEAAAAAAEATVDTATVESEEVEPEKEEPMEVEEAKEPEKEAEVEKEKDEKVEEKQTEDVAAVLEQQDEAETSDIFDAPSSPLEKNSSNLDESVVALSQGNDTINLNDTNDSQDSLEDKLSRMDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MN85</accession>
    <name>A0A8J2MN85_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Similar to atpsckmt: ATP synthase subunit C lysine N-methyltransferase (Xenopus laevis)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HICCMSTLAB_LOCUS4205</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ANT/ATPSC lysine N-methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5084812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MN85"/>
    <dbReference type="OrthoDB" id="66144at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016279">
        <property type="term" value="F:protein-lysine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905706">
        <property type="term" value="P:regulation of mitochondrial ATP synthesis coupled proton transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026170">
        <property type="entry name" value="FAM173A/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13610:SF9">
        <property type="entry name" value="FI06469P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13610">
        <property type="entry name" value="METHYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="25"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAG5084812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="199" mass="21926" checksum="7133F97DA4949F72" modified="2022-05-25" version="1">MEELLEVQNNNITNQISRPTSKAGLVLIGITGGIGLGLTVISIPFVSPALRKICLPYVPATNQQLKNVLLALRGRSGTVIDLGSGDGRLVLAAAKNNFNAYGVELNFWLVTYSKLLAYSQGLSSKAVFYRENLWNLNLSKYDNVVLFGVQSMMQEIESKFIAELKKDCTIVVCRFPLPNLVPVKTIGHGVDRVWVYKPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MND5</accession>
    <name>A0A8J2MND5_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Similar to RNF25: E3 ubiquitin-protein ligase RNF25 (Bos taurus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HICCMSTLAB_LOCUS8363</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5096743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MND5"/>
    <dbReference type="OrthoDB" id="432311at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033554">
        <property type="term" value="P:cellular response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009893">
        <property type="term" value="P:positive regulation of metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051246">
        <property type="term" value="P:regulation of protein metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd23818">
        <property type="entry name" value="RWD_RNF25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000050">
        <property type="entry name" value="eIF-2-alpha kinase GCN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039133">
        <property type="entry name" value="RNF25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006575">
        <property type="entry name" value="RWD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13198:SF4">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RNF25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13198">
        <property type="entry name" value="RING FINGER PROTEIN 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05773">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17123">
        <property type="entry name" value="zf-RING_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00591">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50908">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RWD" evidence="3">
        <location>
            <begin position="43"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG5096743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="272" mass="31569" checksum="E0D5E3984C33D6D1" modified="2022-05-25" version="1" fragment="single">LVRTTQNQTFNQRNKGYTHIYAAIGMIITLEMSEDTIDERLSEEIEALCAILLDNEFKVQKNDRGFPDTIEIQIFPSTGEDPQSQYVCITLIVHLVSDYPDVPPKISLKNPRGLDESTLKIIQKELEVKCQKFSGQPVVFELIELVREHLTQKNLPTGQCVVCLYGFRDGDKFTKTECYHYFHSHCLAAHIIASERYYREELDKLPQWQQDIAKEFKVLIENARCIGVLPKNLIDEQKEAYCMDIDIDRGIEDRLKEKKKKHRSGSLTRKIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MP23</accession>
    <name>A0A8J2MP23_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">Hydroxymethylglutaryl-CoA synthase</fullName>
            <shortName evidence="11">HMG-CoA synthase</shortName>
            <ecNumber evidence="3 11">2.3.3.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">3-hydroxy-3-methylglutaryl coenzyme A synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">HICCMSTLAB_LOCUS9318</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the condensation of acetyl-CoA with acetoacetyl-CoA to form HMG-CoA.</text>
    </comment>
    <comment type="function">
        <text evidence="8">This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>acetoacetyl-CoA + acetyl-CoA + H2O = (3S)-3-hydroxy-3-methylglutaryl-CoA + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10188"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43074"/>
            <dbReference type="ChEBI" id="CHEBI:57286"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.3.10"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:10189"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 11">Metabolic intermediate biosynthesis; (R)-mevalonate biosynthesis; (R)-mevalonate from acetyl-CoA: step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the thiolase-like superfamily. HMG-CoA synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.3.10" evidence="3 11"/>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5099968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MP23"/>
    <dbReference type="OrthoDB" id="1269963at2759"/>
    <dbReference type="UniPathway" id="UPA00058">
        <property type="reaction ID" value="UER00102"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004421">
        <property type="term" value="F:hydroxymethylglutaryl-CoA synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006084">
        <property type="term" value="P:acetyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010142">
        <property type="term" value="P:farnesyl diphosphate biosynthetic process, mevalonate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016126">
        <property type="term" value="P:sterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00827">
        <property type="entry name" value="init_cond_enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.47.10:FF:000008">
        <property type="entry name" value="3-hydroxy-3-methylglutaryl coenzyme A synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013746">
        <property type="entry name" value="HMG_CoA_synt_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013528">
        <property type="entry name" value="HMG_CoA_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010122">
        <property type="entry name" value="HMG_CoA_synthase_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01833">
        <property type="entry name" value="HMG-CoA-S_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43323">
        <property type="entry name" value="3-HYDROXY-3-METHYLGLUTARYL COENZYME A SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43323:SF2">
        <property type="entry name" value="HYDROXYMETHYLGLUTARYL-COA SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08540">
        <property type="entry name" value="HMG_CoA_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01154">
        <property type="entry name" value="HMG_CoA_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="11" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="6 11" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="11" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="4 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Hydroxymethylglutaryl-coenzyme A synthase N-terminal" evidence="12">
        <location>
            <begin position="2"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="Hydroxymethylglutaryl-coenzyme A synthase C-terminal" evidence="13">
        <location>
            <begin position="176"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="9">
        <location>
            <position position="84"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="9">
        <location>
            <position position="118"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="9">
        <location>
            <position position="253"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="210"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="258"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="262"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00056639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR610122-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR610122-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU364071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF08540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CAG5099968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="459" mass="51361" checksum="BB23D9CA35164E08" modified="2022-05-25" version="1">MWPENVGIKAIELYFPAQYVDQVDLEKYDGASAGKYTIGLGQSKMGFCNDREDINSLCLTVTHRLLDRNNIKPSEIGHLEVGTETILDKSKSVKSVLMQLFEPYGATDIEGVDTTNACYGGTAAVFNAISWVESSSWDGRLALVVAADNAVYATGSARPTGGAGAIAMIIGPNAPLVFDRGLRASYMKHAYDFYKPDLRSEYPVVDGKLSIQCYLSALDNCYKKYCEKVDKSSSSASTSKNVTLKYFDAVIFHSPYCKLVQKSFARLAFIDFLKEKNSPETPELEKFKNLKLEDTYFDRDVEKAFMKTSNEDFKDKTEPSLFIANLVGNMYTPSVYSGLVSLLINKPIEQLLGKRIGVFSYGSGLASSMYSLTFGNDKAAEEQLRKICNNLDYIKVQLDARKLITPEEYTEILAMREKNCHTAPYEATASIDPMFPGTYYLVKIDQMHRRSYQRLPLIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MPV7</accession>
    <name>A0A8J2MPV7_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 14">Dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol alpha-1,2-glucosyltransferase</fullName>
            <ecNumber evidence="4 14">2.4.1.256</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">HICCMSTLAB_LOCUS9970</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol alpha-1,2-glucosyltransferase that operates in the biosynthetic pathway of dolichol-linked oligosaccharides, the glycan precursors employed in protein asparagine (N)-glycosylation. The assembly of dolichol-linked oligosaccharides begins on the cytosolic side of the endoplasmic reticulum membrane and finishes in its lumen. The sequential addition of sugars to dolichol pyrophosphate produces dolichol-linked oligosaccharides containing fourteen sugars, including two GlcNAcs, nine mannoses and three glucoses. Once assembled, the oligosaccharide is transferred from the lipid to nascent proteins by oligosaccharyltransferases. In the lumen of the endoplasmic reticulum, adds the third and last glucose residue from dolichyl phosphate glucose (Dol-P-Glc) onto the lipid-linked oligosaccharide intermediate Glc(2)Man(9)GlcNAc(2)-PP-Dol to produce Glc(3)Man(9)GlcNAc(2)-PP-Dol.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>an alpha-D-Glc-(1-&gt;3)-alpha-D-Glc-(1-&gt;3)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + a di-trans,poly-cis-dolichyl beta-D-glucosyl phosphate = a alpha-D-Glc-(1-&gt;2)-alpha-D-Glc-(1-&gt;3)-alpha-D-Glc-(1-&gt;3)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + a di-trans,poly-cis-dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:29543"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19502"/>
            <dbReference type="Rhea" id="RHEA-COMP:19512"/>
            <dbReference type="Rhea" id="RHEA-COMP:19522"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57525"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:132522"/>
            <dbReference type="ChEBI" id="CHEBI:132523"/>
            <dbReference type="EC" id="2.4.1.256"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:29544"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the ALG10 glucosyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.256" evidence="4 14"/>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5100897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MPV7"/>
    <dbReference type="OrthoDB" id="4769at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106073">
        <property type="term" value="F:dolichyl pyrophosphate Glc2Man9GlcNAc2 alpha-1,2-glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006488">
        <property type="term" value="P:dolichol-linked oligosaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016900">
        <property type="entry name" value="Alg10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12989">
        <property type="entry name" value="ALPHA-1,2-GLUCOSYLTRANSFERASE ALG10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12989:SF10">
        <property type="entry name" value="DOL-P-GLC:GLC(2)MAN(9)GLCNAC(2)-PP-DOL ALPHA-1,2-GLUCOSYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04922">
        <property type="entry name" value="DIE2_ALG10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028810">
        <property type="entry name" value="Alpha1_2_glucosyltferase_Alg10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 14" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="16"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="70"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="258"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="295"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="325"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="370"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="400"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="436"/>
            <end position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00044727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRNR" id="PIRNR028810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CAG5100897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="476" mass="55856" checksum="1B7BDA5251AA77C6" modified="2022-05-25" version="1">MVIIKSLFLEAINRPIIYQSIVSFTFVLLTTLLFLFLNKIQPDHYIDEVFHIPQTKKYCNGSFFEWDKKITTLPGLYILSAIILAPFQLCTTIYLRSINLAGTCINLYLIYQILSTKKWVQKCKAENRTWLPFMVSISVTLLPPLYFWHFLYYTDVLSVNLVLMMFLLHQRQYYKNSAIIGALAILARQTNIIWLILLMGERVLTIIEAETPQSISALQDRGIHGTSIHARLIWNNVRHYVQRGIGPFGSFVMRIISYLKYQLTVILLFVAFVIWNRGIVLGDRSAHVATIHLPQMFYFSIFTLAFSWPYMLPHVKSFIQWICKHWIITGLCLAIVTAIVHSNTLVHPYLLADNRHYVFYMWNRFIGRYYFAKYALIPLYGFAIYATVMCLQDMRYLSKVLYAGCIAVVLIPQLLLEPRYFIIPYILVRLSLPEPKLWQISLELMTTLVINFLQFYIFVTKTFYWTDQEGPQRLSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MPZ2</accession>
    <name>A0A8J2MPZ2_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS4931</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5088662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MPZ2"/>
    <dbReference type="OrthoDB" id="7669890at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035224551" evidence="2">
        <location>
            <begin position="23"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5088662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="104" mass="11568" checksum="426CDECDB618FEF4" modified="2022-05-25" version="1">MFNRKKYLLVLVVTIIATVVQSKMVADAPPDLVMEKTTTKGVVGSLTSYLWPFTSVALQFINSILIHTKNMQLPCTIYNLSKLEYSCTPYHANVIDDSGAPMAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MQ21</accession>
    <name>A0A8J2MQ21_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Endonuclease/exonuclease/phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HICCMSTLAB_LOCUS11176</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5102772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MQ21"/>
    <dbReference type="OrthoDB" id="7700971at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14529">
        <property type="entry name" value="Exo_endo_phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="3">
        <location>
            <begin position="402"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="72"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="120"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="72"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG5102772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="580" mass="65811" checksum="1CF55947A2CD3783" modified="2022-05-25" version="1">MCGTMDILRINSHMLMMMNSKMIEQYILQKNNLDQKTTPVIPPKRGRASTQQLLAVAANTCTPITNFIIDSKRKRESADHSPPEEQDQPQKLIKKGVTPVDFTSSVSTELNDTVIMEKILEELKDMRTDQAKKHKELTDKLNKKLKDDEIAFDGIQKNLDSLRNELQDSKTDLNKRIEALKKITNEIIKQLNSRIDSLERENKKTKISIVGLSLTSNNHAEEIKIFLESKFEECIPSISLIEFTMRLIVDLEREIDWNVRQLIKQLRTEGKNCIRKGNKVLVDDLVYSWSEKANKMLSQLKKNHAHSSSMVQSGNFSKNSLIGNLDIIATCKTWVTQPYSPGFLENFNTYWSKALREHAVGRASGGLLTAIIKQHDNSLIDASPWWIFNEIQLGSSVAILGSVYLHKCLDFNYLLETLQGTIDDIKATRSFDLFIIGGDMNAKVGLLNPWPADLFAGYQILDTFRTTDDSTCERGRKIMDFMVENDFVLINGKTISDSPAQPTFDCSGSSIIDLIWIDISSLHVVNDLEVLLETSLSDHHPVCLSISLETFIQPDKNENVKSARLVRINWSENAADQYLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MQ28</accession>
    <name>A0A8J2MQ28_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Similar to colt: Congested-like trachea protein (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HICCMSTLAB_LOCUS5022</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5088906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MQ28"/>
    <dbReference type="OrthoDB" id="14252at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015227">
        <property type="term" value="F:O-acyl-L-carnitine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902603">
        <property type="term" value="P:carnitine transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006839">
        <property type="term" value="P:mitochondrial transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050567">
        <property type="entry name" value="Mitochondrial_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624:SF4">
        <property type="entry name" value="CONGESTED-LIKE TRACHEA PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624">
        <property type="entry name" value="MITOCHONDRIAL BASIC AMINO ACIDS TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="86"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="217"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="26"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="121"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="216"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAG5088906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="308" mass="34391" checksum="C9DDC639237E14D4" modified="2022-05-25" version="1">MDLNNKNPANLYPEEDRTRVLLVRDRPPGKYFIAGGFGGLCTTLCGHPLDTIKVRMQSKPSEYRNTWDAMFKIIHQEGPSGLYKGMMAPLVGIVPIFGLSFFSFSLGKKLVAEPNQRKEDLSVSQLFLAGMFSGLATIPLSVPGERVKCLLQMQIGKKTLFHGFMDCALKLYRNGGVKNLYVGTSATILRDLPASGVYFSVYDILMRLFANHFKETLMWHSIFAGGFAGMINWVVAMPADVLKSRLQTSSIDEYPRGMRSLLPEILRQEGPWALYRGVVPIMIRAIPANATCFFGIEVAMKILDSYFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MQF9</accession>
    <name>A0A8J2MQF9_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein bL34m</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">39S ribosomal protein L34, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HICCMSTLAB_LOCUS10226</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bL34 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5101153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MQF9"/>
    <dbReference type="OrthoDB" id="431691at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.3980:FF:000001">
        <property type="entry name" value="Mitochondrial ribosomal protein L34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.3980">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000271">
        <property type="entry name" value="Ribosomal_bL34"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01030">
        <property type="entry name" value="rpmH_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14503:SF4">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN BL34M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14503">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOMAL PROTEIN 34 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00468">
        <property type="entry name" value="Ribosomal_L34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAG5101153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="99" mass="11776" checksum="D166266D8C4B1D72" modified="2022-05-25" version="1">MFGKIIPIFTQVIPSIGIKTVRQFNTTYTALKGVRQVPWKIDHTKWPMTPIRRKMRDNFPYPNEVKRVRTHGYQTRMSTLHGRKILMRRILAGRFILSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MQN4</accession>
    <name>A0A8J2MQN4_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Similar to sbf2: Myotubularin-related protein 13 (Xenopus laevis)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">HICCMSTLAB_LOCUS10798</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the eukaryotic ribosomal protein eS27 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5102004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="74314at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13208">
        <property type="entry name" value="PH-GRAM_MTMR5_MTMR13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14534">
        <property type="entry name" value="PTP-MTMR5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.100:FF:000001">
        <property type="entry name" value="40S ribosomal protein S27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11500:FF:000006">
        <property type="entry name" value="SET binding factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11500">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.100">
        <property type="entry name" value="Zn-binding ribosomal proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00371">
        <property type="entry name" value="Ribosomal_eS27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046349">
        <property type="entry name" value="C1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001194">
        <property type="entry name" value="cDENN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005112">
        <property type="entry name" value="dDENN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043153">
        <property type="entry name" value="DENN_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004182">
        <property type="entry name" value="GRAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030564">
        <property type="entry name" value="Myotubularin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010569">
        <property type="entry name" value="Myotubularin-like_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002219">
        <property type="entry name" value="PKC_DAG/PE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000592">
        <property type="entry name" value="Ribosomal_eS27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023407">
        <property type="entry name" value="Ribosomal_eS27_Zn-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022096">
        <property type="entry name" value="SBF1/SBF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037516">
        <property type="entry name" value="Tripartite_DENN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005113">
        <property type="entry name" value="uDENN_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10807">
        <property type="entry name" value="MYOTUBULARIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10807:SF109">
        <property type="entry name" value="SET DOMAIN BINDING FACTOR, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00130">
        <property type="entry name" value="C1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02141">
        <property type="entry name" value="DENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02893">
        <property type="entry name" value="GRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06602">
        <property type="entry name" value="Myotub-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01667">
        <property type="entry name" value="Ribosomal_S27e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12335">
        <property type="entry name" value="SBF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03456">
        <property type="entry name" value="uDENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00109">
        <property type="entry name" value="C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00801">
        <property type="entry name" value="dDENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00799">
        <property type="entry name" value="DENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00568">
        <property type="entry name" value="GRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00800">
        <property type="entry name" value="uDENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57889">
        <property type="entry name" value="Cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="Zn-binding ribosomal proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50211">
        <property type="entry name" value="DENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51339">
        <property type="entry name" value="PPASE_MYOTUBULARIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00479">
        <property type="entry name" value="ZF_DAG_PE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50081">
        <property type="entry name" value="ZF_DAG_PE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="7" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="UDENN" evidence="12">
        <location>
            <begin position="21"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="domain" description="Myotubularin phosphatase" evidence="13">
        <location>
            <begin position="1158"/>
            <end position="1699"/>
        </location>
    </feature>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="11">
        <location>
            <begin position="1837"/>
            <end position="1887"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="10">
        <location>
            <begin position="1937"/>
            <end position="1988"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="810"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1323"/>
            <end position="1387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="818"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="830"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1366"/>
            <end position="1377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CAG5102004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="2092" mass="235406" checksum="3EECE7F4F133A039" modified="2022-05-25" version="1">MLNTVCSPQPPEYTEMSRLADYFVVVGYDHGKERAGTSNGIIVQRFPEKDWPDTPFIEGIEWFCQPQGWALSTERQEPRFFVSILTDIDANRHYCACMCFNETVSIVPSKPVDEEEEPVDGVNRTLVRAIPAITHHSIMYAPKCLVLVSRLDYIETFRNCLGIIYTVYVENHEIPLETLVGNILGCIQVPPAGGPQVRFSIGAGDRQALQPPISPSLPITHTSVNLLFQQLGIRNVLVLFCAVMTEHKILFHSASYSRLTESCRALTALMYPFRYTHVYIPLLPAALVEILSTPTPFIMGVHSSLKHETAELMDVIVADLDGGSIMVPDGLSLALLPEPLLSQTQDALSLVLQPQLTSADHAFPPAVVTATDPPMLDKELRAVFMRTFAQLLQGYRSCLTLIRIHPKPVITFHKAAFVGERGLTDCDFTIRVLDCMFFTSFIAERGPPWRPCDIWDELYSNISDQLKQESQDHGLVLTHIQELAKQLDKNENPNPQMYVQKILKPPEGAFARIHQPEFPHINSEQVQAIIDEGLTKNNLKVRLSTLQPRIVPSGPHISMVHDTRHLVSNSARRLEVLRSCVNCIFENKISDARKTFPAVLRALKSKTARLALCMELSQHVIGNKAMLEHQQFDLVVRLMNCALQDDSAMDEHGVAAALLPLATAFCRKLCTGVIQFAYTCIQEHAVWQNQQFWEDAFYQDVQKDVKRLYLPADNLMRLGNEGLISPISPREYKEFSLRDRTSMYRSQEPSALEIAAEQMRIWHTIDPDKQKELVASEESTMYSQAIHYANRMVYLLVPPDISAKTHRQDHVYDDERTSNSVTNSVPSDSGDAESGFEETDPGETGIAVIRMVSRFVDRVCTEGGVSADHVRCLHQMVPGVVHMHIETLEAVYRESKTLPPIQKPKILTPNMLPGEEVIMDGLRVYLLPDGREESVVGLPRTPPLLPAEGAIFLTNYRIVFKGTPCDPFACEQMVVRAFPVTSLTKEKRCAVQHLVHLDQCLQEGLQLRSCTFQLIKLAFDEEVTPENIDTLRKLVNKARYPPHIFHHFAFNGQILVAPTSHQKGKEKNATLKGFAKKTLLKTARKAGFKPKQSSKRQKYVLPNMNLNSGNKYMTSPGRMSLPVTDNNDLSHDDDLSIDEFEVTGFITAPPTDAKTLERLSERSYVRDWYRLGLSPNNLHNNRRNEPFRLTSVNCAYMMCRSYPALLVVPNLITDESIRRFCRLYRHSRMPVATWRHPRTKALLIRGAGYHGKGVIGMLKAHPSTATNLKTTSSETTSTLEQEKYLMALVAATPAAVLRQGSAWGMSDSSLSIDSLLIAAEDRNNPTPEQSRRNPFNKAIGTLSSSAGKGPKNFGRWGSLKDKRHNSQASLTSVNQRGTVRHSADSDSGTECVHTFQRAALYILGEKAHMRGVKAESSPKIDFIPVEYCDLRHTKTAFKKLMRACIPSSSNVEPDQSFYKLIESSEWLQQLQNLMQLSGAVIDLMDVQGSSVAICLEDGWDTTTTVCSVAQICLDPHYRTIEGFRTLIEKEWLGFGHRFGHRSNLAANSQTANFTPTFLQFLDIVHQIQKQFPLAFEFNDYYLRFLAYHSVSCRFRTFLLDCEFDRVECGITAVEDKRGSLTSHHKGVDTGSDDEIVYPGGRLAGTNIGCNLGLSIFDYIEKQHARCPLFFNFMYTPNSEHPVLRPVSHLPSLDIWQYYFEEELAHGPAYDLEILQQDSQQEEESEAADGTAKSSRKIVTLGYDNVNSMVPDQFTHLLEEIHKLETELGHLPQKWKILWDKLELPNTDSLARHVSFSTALVRYHGRLIHKRSTLELLLRGKLAGGNSTGNESSVYAHPHRFERLDTATPTHCDACSGVLWGPVKAGLRCVDCGHICHDKCADSVPKNCTKYKTAADNLQSHTLTRSGNDTGSVNSSVATIQTSSQQYYEQFSSNVAENRTHEGYLYKRGALLKGWKQRWFVLDCIKHQLRYYDAMEDSHCKGYIDLAEVVSVNPAAPTPGPPKKTDDKMPLAVDYLHPSPQEEKRKHKLKRLVQKPNSYFMDVKCPGCYAIKTIFSHAQRPVECDGCRTILCTPTGGKARLTEGCSFRRKVQC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MQY3</accession>
    <name>A0A8J2MQY3_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Similar to eg: Protein embryonic gonad (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">HICCMSTLAB_LOCUS11101</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nuclear hormone receptor family. NR0 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5102610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MQY3"/>
    <dbReference type="OrthoDB" id="5850793at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.50.10:FF:000034">
        <property type="entry name" value="CLUMA_CG002674, isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050200">
        <property type="entry name" value="Nuclear_hormone_rcpt_NR3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001628">
        <property type="entry name" value="Znf_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48092">
        <property type="entry name" value="KNIRPS-RELATED PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00105">
        <property type="entry name" value="zf-C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00047">
        <property type="entry name" value="STROIDFINGER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00399">
        <property type="entry name" value="ZnF_C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00031">
        <property type="entry name" value="NUCLEAR_REC_DBD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51030">
        <property type="entry name" value="NUCLEAR_REC_DBD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-0675">Receptor</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Nuclear receptor" evidence="13">
        <location>
            <begin position="8"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="104"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="148"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="300"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="104"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="118"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="149"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="306"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="359"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CAG5102610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="390" mass="43660" checksum="B5E6652A69369418" modified="2022-05-25" version="1">MVLLMVMNQQCKVCGEPAAGFHFGAFTCEGCKSFFGRSYNNLNSISECKNGGECVINKKNRTACKACRLRKCLLVGMSKSGSRYGRRSNWFKIHCLLQEQQAQQQQQSLHHQQQQSLPSRPTPQNTTPPRLQQRSKEDSLMLGLEEYKNSTSPSISSPESQNSDSSIEVSERRAAYSLHPGFRPLHPHLGTPDLATLGKDMMGLPLGFPFGSMPMMPPAFLPPSMSMISPYLYASYPHNPSLISHSLNSSISESNTPLITDECKNINNNNRYTANHNVVEELPTKKRVYLDAVLKSQLPSPPLKKMKLDSPRFDESPEPDCERFETNFPDDCLPPQDTPIDLSMKAASVIATSEDSDDERQTQDEVDFESDRESPVIMRRPAPIDLTTRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MV57</accession>
    <name>A0A8J2MV57_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Similar to GET4: Golgi to ER traffic protein 4 homolog (Homo sapiens)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HICCMSTLAB_LOCUS10043</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GET4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5100970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MV57"/>
    <dbReference type="OrthoDB" id="10252405at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071818">
        <property type="term" value="C:BAT3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045048">
        <property type="term" value="P:protein insertion into ER membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000060">
        <property type="entry name" value="Golgi to ER traffic protein 4 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007317">
        <property type="entry name" value="GET4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12875">
        <property type="entry name" value="GOLGI TO ER TRAFFIC PROTEIN 4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12875:SF0">
        <property type="entry name" value="GOLGI TO ER TRAFFIC PROTEIN 4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04190">
        <property type="entry name" value="GET4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="295"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="307"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAG5100970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="323" mass="37164" checksum="BCE176248EC78049" modified="2022-05-25" version="1">MASRYNQGIQRVLGKLEASVNSGNYYEAHQMYRTLYFRYLAKKKYMDLLELLYNGAILLLQRDQHASGADLGILFIDVLNKAETTEPTSYFEKITNLFSIMKPGTPERETFLHNALRWSLKHTNCKWGHPELHKMIAQVFWQEKNYTMARQHFVYSDDGAGCAAMLVELHQQRGYSNEVDLFIAQVVLQYLCLHNASTAQEAFDSYTSRHPKINSEPPYLLPLLNFLFFLLKTIQLSSFGAFTVLCEQYQLSLNRDPSYRTYLDKIAQLFFDVPAPRSRRQGLFGSLLQSFFNGLEDDESDGEETSRQASNNASTSHAVQELD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MVM6</accession>
    <name>A0A8J2MVM6_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase (Mus musculus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS9046</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5099403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MVM6"/>
    <dbReference type="OrthoDB" id="6474464at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003830">
        <property type="term" value="F:beta-1,4-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006044">
        <property type="term" value="P:N-acetylglucosamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006813">
        <property type="entry name" value="Glyco_trans_17"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12224:SF0">
        <property type="entry name" value="BETA-1,4-MANNOSYL-GLYCOPROTEIN 4-BETA-N-ACETYLGLUCOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12224">
        <property type="entry name" value="BETA-1,4-MANNOSYL-GLYCOPROTEIN BETA-1,4-N-ACETYLGLUCOSAMINYL-TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04724">
        <property type="entry name" value="Glyco_transf_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="9"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5099403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="438" mass="50453" checksum="C4A44E292EF32520" modified="2022-05-25" version="1">MQNRLDGKLILLYTLLVLQVFIVMIYVISTPKSEYDLSTTRNPVSFIDTQTVQVPTYHNQIKLKIPKPTTPTISGEIKLKNTRTLEFFIIKNQTACWKEGLDNDKIKSTENERELDRCICKPGWHGVDCGEPEVVWRAIMASKQNIKLTRRRTSRRLIYVFSVDDFNSAIAEVIVEELYNVVDLFVICDYSNSEENFKHKLAKGLLEGHQNKILYININSGGGKTARKPKRVISRFIWDKISVQVKNIKHDDIYVMTDSEEILNLRALMFLKVYDGWPQPIGFRLRWSVFGFFWRHPLKTTITVGACTVGFLYNAFRSNALVLSQLSDEISEQRDNLGLVIGDLNHYGGWYCHYCQSPANIVNLIEREGKNNVPDGTKNLDVAFIEDIIGGGVWIDGKTSLLRAYKSHESYFAPETVIANPFKYDWLVDNFYAKLDYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MVY7</accession>
    <name>A0A8J2MVY7_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glycosyltransferase family 92 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS9335</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5100002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MVY7"/>
    <dbReference type="OrthoDB" id="6433308at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="30"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5100002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="463" mass="54223" checksum="424089B6CDB7022D" modified="2022-05-25" version="1">MKVRTVPYNQKHQSSYNPSTSIKNQKMRKYYQAALALTAAVSLVALLFYRHEYNKLRFVLQVFNYFGTPQKNSLNCTNNIQVTNTYHQAASTSWQRLSEDFYIYSAYSYDEGEIKAIGFGKHSSSNNYYCRVLFDDQLEYVQGKFLVQKIDENRQDLNNDDLINNDDDQEYSGYLFTCKYEKLPDKDVVGMQVVDDKLKNYDSIPIIQVQTLYNNFNSNKTGTIICVAPPESKPLKHIDMISFLAFHDYVGWDNFIVYDYGIPFVFNEAVRKMSLFSNVQWNFTYSAVPWNFPYAQISRRVIRNLIEADCLYRTFSRASFAVTLAWDEYVNLKYHTSVEHVLSDLNKVNGKIDDKFRLNAVVFCTDYADSDSVNSPTPVILRTTRRLRNVDKDEPLFIYKRDHISSNDITQQEMDELMIINRYKKCNTNDRRQIVNGVLRFAESMPSTQIFQYYITGRLFSHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MXE3</accession>
    <name>A0A8J2MXE3_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HICCMSTLAB_LOCUS10528</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5101626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MXE3"/>
    <dbReference type="OrthoDB" id="6140671at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005918">
        <property type="term" value="C:septate junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035151">
        <property type="term" value="P:regulation of tube size, open tracheal system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019991">
        <property type="term" value="P:septate junction assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004031">
        <property type="entry name" value="PMP22/EMP/MP20/Claudin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21284">
        <property type="entry name" value="EG:80H7.2 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21284:SF12">
        <property type="entry name" value="EG:80H7.2 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13903">
        <property type="entry name" value="Claudin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="69"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="109"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="153"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="196"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="214"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAG5101626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="223" mass="26407" checksum="662F08DB51549D07" modified="2022-05-25" version="1">MLKERDSPARKKDNQSYQETFSEFKHMGLWEYCFKDFRFPQFQFDELYNGCYHVFSDKLHPFREWLLPFWLMSVQFFVTVALMLSFFGQAVIALVLVRWPLRFVLRYEWILSSIACICDLIAGVFLFLAVAIFGGQCWRRDWLLYPNFNYLSWSYGLGVISFMFHIVGAFFLYLDARAGYKLRKQSRNLVVQMQPNPQSHHGSHHGSHFGSQHSSHHRMGGFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MXI0</accession>
    <name>A0A8J2MXI0_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Gamma-tubulin complex component</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HICCMSTLAB_LOCUS10664</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
            <location evidence="5">Cytoskeleton</location>
            <location evidence="5">Microtubule organizing center</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the TUBGCP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5101763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MXI0"/>
    <dbReference type="OrthoDB" id="66546at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000930">
        <property type="term" value="C:gamma-tubulin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000922">
        <property type="term" value="C:spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043015">
        <property type="term" value="F:gamma-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051011">
        <property type="term" value="F:microtubule minus-end binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031122">
        <property type="term" value="P:cytoplasmic microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007020">
        <property type="term" value="P:microtubule nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051225">
        <property type="term" value="P:spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22572">
        <property type="entry name" value="GCP5_NTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1900">
        <property type="entry name" value="Gamma-tubulin complex, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007259">
        <property type="entry name" value="GCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059169">
        <property type="entry name" value="GCP5_N_ext"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040457">
        <property type="entry name" value="GCP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042241">
        <property type="entry name" value="GCP_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041470">
        <property type="entry name" value="GCP_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19302">
        <property type="entry name" value="GAMMA TUBULIN COMPLEX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19302:SF33">
        <property type="entry name" value="GAMMA-TUBULIN COMPLEX COMPONENT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04130">
        <property type="entry name" value="GCP_C_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17681">
        <property type="entry name" value="GCP_N_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3 5" id="KW-0493">Microtubule</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gamma tubulin complex component protein N-terminal" evidence="7">
        <location>
            <begin position="305"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="domain" description="Gamma tubulin complex component C-terminal" evidence="6">
        <location>
            <begin position="759"/>
            <end position="1053"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF17681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG5101763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="1100" mass="126978" checksum="9017F507C60037BD" modified="2022-05-25" version="1">MGTYITNDIYKDLKLLINSLTGFEEKGQTARHFKLCEKFVLSNIKNHNYLPINSHIVRRSVNDLKEKFIVHGNYKVAERFTSLVDSLLTSSAFNFDQHPQHDLQWTLLSLLIELSNETSKSIISTGDDSIDALDLGSDDESDENFDSRTVDLNDSRTDEINWEEYLKEGQQEFFTGSSQSTLKKKSSSNCPAELSLKSQAKSRSLEKFTRIVESQKWLELNVENTWWSEKNYQNVQVLSVFPQAHFCEIYESFRQSTSEAGKSGTSLISEYQACREVLWMLTHQAVTSSGDYDNIGVVYEKTLDEFSVNKNISIPSLTPKAFQSAFGSFVEYFSMVKKLNCLLENTDINTSNIKSLFPITYENYSTSVMQYFNRLKEDIIDVEKKSMQRKFNPTTFLTLSKDLEPIVGQLSMLSDIHRSVLTDELLKSQTNWEKSYRLLLNLYRQVENSSSRSRTNLCASLYLSSLKIYLNIIDTWLTEGRLEDFRDEFLVFKKNFSNNFESTSSEDGDRIKMASFAIRPIEKDGLVIDPITKKLLRKIEEMGRNIDLLVTLNRISDMWKMNAEIYDSTRIPLSEEFISYVIMELSKYGNDSSEIDHSDQLDAANVDYEIDRSTNASDLSKVLVKETDTDNLDNGLDAACLINLEENIRQQIRQINNPFLMKVFQNYLPSLTTPTLSFVNFPATSSVDTVDFREKNLEDRREVRTQWGVINIFDKLEGMSEFILPFRKALETTLDTILDRRYSCASKLVKNILIDEYKLERHLKLMRSIYMMERGHVMRKFYQLMFQEIETGNLATYRINPYGDLTNILEQVLSDEWRDSSSQNRWSITIVPSDGGNTTRQVIQAIENTTLDYSVDWPINMVLAEPVLVKYNEIFRFQLKLKWALWTLNNLLFTDLEGSSEDMKDFFFHFNARRLECLRFWLLHAIGSIHTYLSGQVLQSLGLILENSLAQAKDLDTIIQIHNDYLDKAHEHCLQTPQFADIMTTINNLLEMCAHIRDRWKRGVKHLMPQELDVMEKKYIKFHTYLALALHNAVQHKEADYLASLTTAFNCNKSGIITSISSNTVNQTSCVDIQPLIKSLLAEVAHQSYPPSGFPSTKIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MXW4</accession>
    <name>A0A8J2MXW4_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein YIPF</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HICCMSTLAB_LOCUS11148</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Golgi apparatus membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the YIP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5102716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MXW4"/>
    <dbReference type="OrthoDB" id="10256463at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006977">
        <property type="entry name" value="Yip1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039765">
        <property type="entry name" value="Yip5/YIPF1/YIPF2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12822">
        <property type="entry name" value="PROTEIN YIPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12822:SF2">
        <property type="entry name" value="PROTEIN YIPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04893">
        <property type="entry name" value="Yip1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="118"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="158"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="205"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="232"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="264"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="domain" description="Yip1" evidence="7">
        <location>
            <begin position="111"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG5102716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="312" mass="35834" checksum="258840A297E43574" modified="2022-05-25" version="1">MSDPFNKPDNTPFISVENYSTDDIFSGRDRMNLNYEPSVQQNITIHQTETDLKNDIEGFSDSSNTNNAKDNKMFWTLEFYQQFFNVDSHEVFERIKKSMLPKSDNNYLLSHIKPNPDLYGPFWISVTLIFVVAISGNFANYLQTANNGKYHWKYDFHLVSYAAITICLYVWLLPLSIWSGIRWGNNAQEDILQSQLTKTTQDLRILDLLCLYGYSLSIYIPVAILWTIQIGWFQWLLVGVASLMSGGVLLRCLIPLIKSKQKPIFIAVILGMHLLLAAGFMLYFFHVPDRKVTSELTHSQSSTEAIISTKNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MY43</accession>
    <name>A0A8J2MY43_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS12415</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5106748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MY43"/>
    <dbReference type="OrthoDB" id="10258888at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="640"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="152"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="208"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="244"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="304"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="333"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="351"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="380"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="417"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="649"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5106748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="660" mass="74783" checksum="AE59685BD63BD9D5" modified="2022-05-25" version="1" fragment="single">KADEMQNALMAKAADLKKDVDEIRRQMSDKKSSSEKDEADGKHRKKSASKGRKDSKSEVKAASQDSQSELSKLQSQHEEKDDGMTKESTAVEGEKVEDVKNETKSQNLQKSEEEIKEKTRDESATEEDRSSSRDEVSVRSKRSIESGSQVSESDKESVIQTEKADDKKSEDESRNLVDGEKKETEEVKKNTEVEDKKEEMNVVQEVEGNDKEKTLAEDKKEKLDEKAEHDEHSEKVESMKVKSAQETVPQESSPSAPKSVDKQEPEGSASDNLRHIDSSSSSAKSSRKLSHSRPSTGKSRRASSKSSSKKSLFESSEERSPDRSAIVAVIESPEWDEEDEEVAKEIRDVVGDAEPEEDSDAEDEDSLGVLRVIPSTSEEESPRRLKKILRESKRDKLPRVERKSIGSPRGLRIQTKQRRDSGGRDSGIEPSPRVSKIPKRTLKCYPNTEKQQALNIDTITRDVQISLRRYHLERKIFFQLMELKRLQIRHGRANEQVLVKRQVEMFHKAGMSGPALGVAKYDQAYTFKDFETFLYEQLRRLQRRPPSSDKCTDPKQCTKKTHRCHHATSAYTSVPVFTYLGGGSQERDEGSLFPRIESRGKGQMTVVEVTRGEEKQIIALPAEKLDRTKRYFVTFTVRGDNDESDIKTPRNNAQRATKSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MYG4</accession>
    <name>A0A8J2MYG4_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Similar to TRABD: TraB domain-containing protein (Homo sapiens)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HICCMSTLAB_LOCUS11589</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5103597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MYG4"/>
    <dbReference type="OrthoDB" id="48306at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042054">
        <property type="term" value="F:histone methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008170">
        <property type="term" value="F:N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14726">
        <property type="entry name" value="TraB_PrgY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007728">
        <property type="entry name" value="Pre-SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002816">
        <property type="entry name" value="TraB/PrgY/GumN_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046345">
        <property type="entry name" value="TraB_PrgY-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21530">
        <property type="entry name" value="PHEROMONE SHUTDOWN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21530:SF7">
        <property type="entry name" value="TRAB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05033">
        <property type="entry name" value="Pre-SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01963">
        <property type="entry name" value="TraB_PrgY_gumN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50867">
        <property type="entry name" value="PRE_SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0158">Chromosome</keyword>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pre-SET" evidence="7">
        <location>
            <begin position="394"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="domain" description="SET" evidence="6">
        <location>
            <begin position="453"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="32"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="53"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="76"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="618"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG5103597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="618" mass="70211" checksum="80DD5F796DBBD5C2" modified="2022-05-25" version="1" fragment="single">IVQITLTMEHNDSKKGLIGGQGVQQMHMSIIKPQPDPNEPPIVHNKNTTPKSVEIKDKKSYSGPDKDSVIDIDEATNGTESDTEDSSNTNEHFVVTRPFGHNLECDPTIDDRLPETVTLLTTPEGGKVYLVGTAHFSEESQNDVSMIIQAVQPHVVMVELCDARVHILQLDEQTILKEVESLNMQKIKATIKQNGVFNGLIYVLLLNMSAHMTKQLGMAPGGEFRRAFTEAKKIPNCLVQLGDRPINITLKRALASLSWWQTLTLFWNLLRSKDPISKEDVERCKRRDLLEELLAEMTAEYPPLGKVFVNERDKYLAHSLQLSVTNSYQCHRCRHFNHSSHRFRDFLRVNIMETGTGVGKMDEYEHPILNVMYVSNNIPGKGIDIDEFESEFTVGCTCKSECTENCYCMKEEVNYINNLFNEDKSSKLILECNSMCLCLNNCKNRLIQHGPIDCLKIIHSELKGLGLSTSKVIEKNKFICEYAGEIIGIDEAKRRTEDNRINKQMNYILIVSEHIGNKKLTTCIDPKYFGNIGRYCNHSCTPNAKLIPVRVNNLIPHLCLFAIKDIQVDEEITFNYSGDVDTSIKNISETPCLCKSIIASDYNLLKDKHIFKVQHYFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MYQ3</accession>
    <name>A0A8J2MYQ3_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS13127</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5108217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MYQ3"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5108217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="108" mass="12431" checksum="821326DADAF7D45B" modified="2022-05-25" version="1">MEYSLFSCAFYIVQVSFNLCCIGDGHIISSLSAEFSWVQEHYYKASYNIISVDYLCPFSSLEFFYMWWSSCQSTSISLHLVCESQFGHFWAVLLSLSTLPSMDSSIMH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>S6CVR4</accession>
    <name>S6CVR4_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Cc_single_32.6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">CcBV_32.6</name>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS6189</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Philos. Trans. R. Soc. Lond., B, Biol. Sci." volume="368" first="20130047" last="20130047">
            <title>Functional endogenous viral elements in the genome of the parasitoid wasp Cotesia congregata: insights into the evolutionary dynamics of bracoviruses.</title>
            <authorList>
                <person name="Bezier A."/>
                <person name="Louis F."/>
                <person name="Jancek S."/>
                <person name="Periquet G."/>
                <person name="Theze J."/>
                <person name="Gyapay G."/>
                <person name="Musset K."/>
                <person name="Lesobre J."/>
                <person name="Lenoble P."/>
                <person name="Dupuy C."/>
                <person name="Gundersen-Rindal D."/>
                <person name="Herniou E.A.Drezen.J.M."/>
            </authorList>
            <dbReference type="PubMed" id="23938757"/>
            <dbReference type="DOI" id="10.1098/rstb.2013.0047"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5092520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="HF586473">
        <property type="protein sequence ID" value="CCQ71242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S6CVR4"/>
    <dbReference type="OrthoDB" id="10298854at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5092520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCQ71242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="251" mass="28647" checksum="CF2FD484FDF355DE" modified="2016-04-13" version="1">MDKYLKYYHKASVVFKYGTQNWSEDSFPHIPRPQASIWSKLHHYMSYRLVFFEKYFLNFFKIHNMSIELPAMAILIGSMAEASGMATCDEYSSWIISELILNNEPGIFTILESKPRESLPTLVRGIGHKSVGVAGADGEIEVVIDAMEMSTLSFPNQFMDVNRRIIFGSDKKKWKSLAVCLGDSVELPLGKDTLKDLSTELESYLNEMTTCRNREELILADTPRANPSDIDEVLEVFFQTLQRKIGILKNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-10-16" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>S6CVV1</accession>
    <name>S6CVV1_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cc_bv8.12_12.3b</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">bv8-12</name>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS1418</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Philos. Trans. R. Soc. Lond., B, Biol. Sci." volume="368" first="20130047" last="20130047">
            <title>Functional endogenous viral elements in the genome of the parasitoid wasp Cotesia congregata: insights into the evolutionary dynamics of bracoviruses.</title>
            <authorList>
                <person name="Bezier A."/>
                <person name="Louis F."/>
                <person name="Jancek S."/>
                <person name="Periquet G."/>
                <person name="Theze J."/>
                <person name="Gyapay G."/>
                <person name="Musset K."/>
                <person name="Lesobre J."/>
                <person name="Lenoble P."/>
                <person name="Dupuy C."/>
                <person name="Gundersen-Rindal D."/>
                <person name="Herniou E.A.Drezen.J.M."/>
            </authorList>
            <dbReference type="PubMed" id="23938757"/>
            <dbReference type="DOI" id="10.1098/rstb.2013.0047"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CAJNRD030001116">
        <property type="protein sequence ID" value="CAG5075264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="HF586477">
        <property type="protein sequence ID" value="CCQ71335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S6CVV1"/>
    <dbReference type="OrthoDB" id="7686918at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5075264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCQ71335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="148" mass="16749" checksum="AFD09204735FEFE7" modified="2013-10-16" version="1">MREFSTAKYVQLPNRVFVPSEWPVKGLESFLSKLTKLVIDDVTSDRVIVLQVQDIPTILVCCGEGEETQYFFQRISSPGQTEAYVIDVVIATMDNLSKKNSMTSEDSSKSSENDISDSDKGISLDNYNIMTHQSENKTAYYFVLIQEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-10-16" modified="2023-09-13" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>S6CWJ7</accession>
    <name>S6CWJ7_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Cc_single_15.3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">CcBV_15.3</name>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS6179</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Philos. Trans. R. Soc. Lond., B, Biol. Sci." volume="368" first="20130047" last="20130047">
            <title>Functional endogenous viral elements in the genome of the parasitoid wasp Cotesia congregata: insights into the evolutionary dynamics of bracoviruses.</title>
            <authorList>
                <person name="Bezier A."/>
                <person name="Louis F."/>
                <person name="Jancek S."/>
                <person name="Periquet G."/>
                <person name="Theze J."/>
                <person name="Gyapay G."/>
                <person name="Musset K."/>
                <person name="Lesobre J."/>
                <person name="Lenoble P."/>
                <person name="Dupuy C."/>
                <person name="Gundersen-Rindal D."/>
                <person name="Herniou E.A.Drezen.J.M."/>
            </authorList>
            <dbReference type="PubMed" id="23938757"/>
            <dbReference type="DOI" id="10.1098/rstb.2013.0047"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5092510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="HF586473">
        <property type="protein sequence ID" value="CCQ71231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S6CWJ7"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5092510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCQ71231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="98" mass="11141" checksum="0F984E302FB05E73" modified="2013-10-16" version="1">MHTLLSTGIILPQQVTVDVVDKHLHCLQAVITFVATKTVENVFMVEIVEKHAVAGPTHRAETIMHRSRRSLQARTNFCTTGRAKDWGLFKYVTYSIYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-10-16" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>S6D2U2</accession>
    <name>S6D2U2_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Cc_single_20.1b</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">CcBV_20.1b</name>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS6092</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Philos. Trans. R. Soc. Lond., B, Biol. Sci." volume="368" first="20130047" last="20130047">
            <title>Functional endogenous viral elements in the genome of the parasitoid wasp Cotesia congregata: insights into the evolutionary dynamics of bracoviruses.</title>
            <authorList>
                <person name="Bezier A."/>
                <person name="Louis F."/>
                <person name="Jancek S."/>
                <person name="Periquet G."/>
                <person name="Theze J."/>
                <person name="Gyapay G."/>
                <person name="Musset K."/>
                <person name="Lesobre J."/>
                <person name="Lenoble P."/>
                <person name="Dupuy C."/>
                <person name="Gundersen-Rindal D."/>
                <person name="Herniou E.A.Drezen.J.M."/>
            </authorList>
            <dbReference type="PubMed" id="23938757"/>
            <dbReference type="DOI" id="10.1098/rstb.2013.0047"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5092373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="HF586473">
        <property type="protein sequence ID" value="CCQ71115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S6D2U2"/>
    <dbReference type="OrthoDB" id="7453903at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5092373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCQ71115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="300" mass="34720" checksum="99F87DE0BA232B9F" modified="2013-10-16" version="1">MIIAILDNLLFPESESAAAQVIYPTQQSTIQYGIGKQQSAIQNGYSNQQSTTPIESDNQPSTIQQENINQIFPSSNISDIIAWLQFTIQQSTTPNGFDFQQYIEQQQEISRVTRLLNELTEKKFITWLRCKNYLSSTDSRSNNEETTLYQEKLNRTLSESDKTYLQQAIARWLSVYEQSTTEFIPKSCIPLLPEKEDMKKAISEHYKTLQDQAIARLLSDDHQSTAQNGSYDQKAEQDEVIRLHHSIEQILTDKLLKQEQSPPVIYYPWGRPCDFTLTSITFYENIYKFHLCALRGFTRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-10-16" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>S6D9K5</accession>
    <name>S6D9K5_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Cc_bv9.7_28.21</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">bv9-7</name>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS6170</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Philos. Trans. R. Soc. Lond., B, Biol. Sci." volume="368" first="20130047" last="20130047">
            <title>Functional endogenous viral elements in the genome of the parasitoid wasp Cotesia congregata: insights into the evolutionary dynamics of bracoviruses.</title>
            <authorList>
                <person name="Bezier A."/>
                <person name="Louis F."/>
                <person name="Jancek S."/>
                <person name="Periquet G."/>
                <person name="Theze J."/>
                <person name="Gyapay G."/>
                <person name="Musset K."/>
                <person name="Lesobre J."/>
                <person name="Lenoble P."/>
                <person name="Dupuy C."/>
                <person name="Gundersen-Rindal D."/>
                <person name="Herniou E.A.Drezen.J.M."/>
            </authorList>
            <dbReference type="PubMed" id="23938757"/>
            <dbReference type="DOI" id="10.1098/rstb.2013.0047"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5092501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="HF586473">
        <property type="protein sequence ID" value="CCQ71223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S6D9K5"/>
    <dbReference type="OrthoDB" id="7687020at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5092501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCQ71223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="136" mass="16207" checksum="1EF59155EE86A14B" modified="2013-10-16" version="1">MTLPKKFAVVQFYEVANLGQNPYKSVPKTWLEFGNSDDVFLRYPTAEELPFSIDRIINYAPPSLSWPRHAATFVCELDTYEECLFLMAHMDVNLPEEYAIMTWKKLSREFRDRQTCQQSSSMFYQLWNWFSSFFNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2E2U0</accession>
    <name>A0A8J2E2U0_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Similar to exosc9: Exosome complex component RRP45 (Danio rerio)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HICCMSTLAB_LOCUS1558</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RNase PH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001116">
        <property type="protein sequence ID" value="CAG5075404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2E2U0"/>
    <dbReference type="OrthoDB" id="10264038at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000177">
        <property type="term" value="C:cytoplasmic exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035925">
        <property type="term" value="F:mRNA 3'-UTR AU-rich region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000467">
        <property type="term" value="P:exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071028">
        <property type="term" value="P:nuclear mRNA surveillance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071035">
        <property type="term" value="P:nuclear polyadenylation-dependent rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016075">
        <property type="term" value="P:rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071038">
        <property type="term" value="P:TRAMP-dependent tRNA surveillance pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034473">
        <property type="term" value="P:U1 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034475">
        <property type="term" value="P:U4 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034476">
        <property type="term" value="P:U5 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.70">
        <property type="entry name" value="GHMP Kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001247">
        <property type="entry name" value="ExoRNase_PH_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050590">
        <property type="entry name" value="Exosome_comp_Rrp42_subfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027408">
        <property type="entry name" value="PNPase/RNase_PH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11097:SF14">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT RRP45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11097">
        <property type="entry name" value="EXOSOME COMPLEX EXONUCLEASE RIBOSOMAL RNA PROCESSING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01138">
        <property type="entry name" value="RNase_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exoribonuclease phosphorolytic" evidence="5">
        <location>
            <begin position="58"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAG5075404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="160" mass="18596" checksum="AA6BCF3DF502BA27" modified="2022-05-25" version="1">MEVSITKCEEKLINATLEENLRLYGKKLNKARKLILHFRSSWKIMFSIVGTKERTIVKVMANVSCDIQQPKLSRLSEGLSSMNVELNPLAATHFEVGRQSEIIALTKQLERCFKDPRCLDMESLRIVANNKLWNIRVDINVINHDGNLVDWRWCYYVLIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2E3J8</accession>
    <name>A0A8J2E3J8_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Similar to QRFPR: QRFP-like peptide receptor (Branchiostoma floridae)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HICCMSTLAB_LOCUS2015</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001116">
        <property type="protein sequence ID" value="CAG5076034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2E3J8"/>
    <dbReference type="OrthoDB" id="10036964at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24243">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24243:SF233">
        <property type="entry name" value="THYROTROPIN-RELEASING HORMONE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 10" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0807">Transducer</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="9">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAG5076034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="60" mass="6687" checksum="A289E7701C16B8A2" modified="2022-05-25" version="1" fragment="single">KAVPFVELTVAHASVLTILAISFERYYAICEPLRAGYICTKARATFLCFLAWVFAAVCTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2E839</accession>
    <name>A0A8J2E839_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS2349</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001117">
        <property type="protein sequence ID" value="CAG5077018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2E839"/>
    <dbReference type="OrthoDB" id="6380108at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035312815" evidence="2">
        <location>
            <begin position="20"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="155"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5077018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="244" mass="27885" checksum="F7D5390139181A87" modified="2022-05-25" version="1">MTFRWIQVIQLMVVSSVCAFETSEEYLRKAMHELQGIQSPLYTNYPFFAGKRYSRTANILQVQQDTRPGYPPKKSEPEVSQYYSQALQSGNAINLPGLKNSLESGQIPTVVGNHLHIPDSSQQQQQFAYYFYPLKSFMDTLQIQESQKQIIINPLFMAISSFVGMALVFMFGVIVLPRILGEFRSRVVHDELLDLTTTVNAAIDKYELTTTRPKTPFGVAMVGIKTRPVQRVKRKKIQRNRTVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2EAI2</accession>
    <name>A0A8J2EAI2_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ubiquitin-like protease family profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HICCMSTLAB_LOCUS462</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C48 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001114">
        <property type="protein sequence ID" value="CAG5073519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2EAI2"/>
    <dbReference type="OrthoDB" id="1939479at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008234">
        <property type="term" value="F:cysteine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003653">
        <property type="entry name" value="Peptidase_C48_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02902">
        <property type="entry name" value="Peptidase_C48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like protease family profile" evidence="5">
        <location>
            <begin position="252"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="41"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="53"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAG5073519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="565" mass="63015" checksum="ECC70B66E1960CDD" modified="2022-05-25" version="1" fragment="single">INDRSDKEDKNDDNFWETESDSSDTFSYNENYSYSSHEEYSDSDQESDDDEINQNGDDNNINNGHLNSPIYEGAPLTLLVKSDDSDDENIAIVNPSAAEITSMPIIFTNLSTDISLQEEVVAYDEYSQIMESDNIGCFEGNVDNENTSTETTIEIQDQLQAAVKSIITSSEISLKMSHIIEENEKLLTNFFKNIPNHEGDDENDNSTVTIDSLLELHKAKLGSGDENLFSTNVGMTVRVTDLKRLIPPNELNDEDIPMQNNSYDCGVFVCFYAKQLSMLKTIPKINTANMNRFRTQMLRNILESHKSSSTSESANSAQNSQISAEMTKEIELPSPQQCNQSNTSMNGVYLYQSAHYHQGSSQLFSHRQAGLQCTAIATYAIAALPNKLSHVTSQDLDEILIGGDSYYLQCRKAATEDMLNVDELLSNFLVKNKLAIIVKKEDISCGSLLDENPLSSLYKSIIQHVLPTIEPDCGYLFITQSKTVSFKYLYSPNVNSPDFFLFNSHPVDENNCIPEEGTDAKARLFRCCGTLALAMALLAGTNLNCGQNNKMWAIYKIKSSISSQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2EBF9</accession>
    <name>A0A8J2EBF9_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Similar to CD63: CD63 antigen (Bos taurus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HICCMSTLAB_LOCUS1045</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001114">
        <property type="protein sequence ID" value="CAG5074374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2EBF9"/>
    <dbReference type="OrthoDB" id="5870230at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1450.10">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018499">
        <property type="entry name" value="Tetraspanin/Peripherin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008952">
        <property type="entry name" value="Tetraspanin_EC2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19282">
        <property type="entry name" value="TETRASPANIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19282:SF428">
        <property type="entry name" value="TETRASPANIN 68C, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00335">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00259">
        <property type="entry name" value="TMFOUR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48652">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="58"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="93"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="240"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="315"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="465"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="557"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="652"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="319"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="469"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="560"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="583"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="595"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="652"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="664"/>
            <end position="677"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAG5074374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="751" mass="84543" checksum="CDC8EEF4F447921F" modified="2022-05-25" version="1">MSGEKFKITKAFICWSNIVFMISGVILMSLGILLLIDNNRILLSRLLNTNESVVKEPIFYYLALIVIGVGFLIALSGLLGCWVSCLANNCVTVLYMIILITLMISQLTVCVLTIFTPNLIGVDIRVVTLLRTLQRNYGLPGRQQFTAALDLAQTTFSCCGINGSNNYGTSWWRLQEVGRRNLVVPLTCCLLNNTNNFDAFLNPVVKDLETCQTLNPVKHQRARHTTGCLEKIEEWTQEQALLLLIIGLSIMFIELCALLSTLMGYKRKSGKLRKKLNKSQHNITAAASFTSTETLGRSYQDCQDEFGGFENRQMWQEGSHQQNQCHQSSSSPKSLIEQWSSNSIKQETSIETLSTTPQHHSSYQERGVDVLFTDPKIRPSTSSQNLSVKPKNLDLIKIFQHSGPKNILKKPGLEFPNDSQFVLSSKSKTVTSIPIKNFKNSLAQNFGTLRRIRPIFPDQHYKAHESLTNNNNNNNNNNNKSVSSRKSKKAQNTNNKNNKHSLEPAGTVSAMIEVFEDHLRTDLPPSSNWALQKNKFGVPLVGMHNACGLPILAHWPQNKAPKKKVKRPAPKPPRTKRQAPTISHEKNIQDRENFCRNQSNKRTPQLKQSENQIEFSKPSCNSAGGFLGPKISYHQNPEANFFRASHRAQFHRRSGPKIRPHKKNCGDKNQDPVDFSRPRAGSLGFMPKIDPYQTTDSINQANYWNGKKFKRATVYAKDDGSSPVDVLLTNLCLNPMARNSTSNMMCCSYKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2EC78</accession>
    <name>A0A8J2EC78_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS1335</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001116">
        <property type="protein sequence ID" value="CAG5075181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2EC78"/>
    <dbReference type="OrthoDB" id="6593154at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5075181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="111" mass="13314" checksum="8322B46DC90B0D2A" modified="2022-05-25" version="1">MLTFTKNGEDISRKIYQIFREQNPKIGVLILQEQEKFVYSLVEEFVDDCFKQANYIIPILTTGYINHINNLTNNDDEESLVNNLDHKYVKYLYSLMRLEYCKNNCHNNRIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2EDF6</accession>
    <name>A0A8J2EDF6_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Large ribosomal subunit protein mL43</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HICCMSTLAB_LOCUS2088</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrion-specific ribosomal protein mL43 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001116">
        <property type="protein sequence ID" value="CAG5076107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2EDF6"/>
    <dbReference type="OrthoDB" id="88at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000257">
        <property type="entry name" value="39S ribosomal protein L43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039927">
        <property type="entry name" value="Ribosomal_mL43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007741">
        <property type="entry name" value="Ribosomal_mL43/mS25/NADH_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21396">
        <property type="entry name" value="39S RIBOSOMAL PROTEIN L43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21396:SF2">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05047">
        <property type="entry name" value="L51_S25_CI-B8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00916">
        <property type="entry name" value="L51_S25_CI-B8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal protein/NADH dehydrogenase" evidence="7">
        <location>
            <begin position="37"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG5076107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="187" mass="21486" checksum="29CF14A394D140B5" modified="2022-05-25" version="1">MSNRSLVIKSGFLRAPLSNGIGRYVGQLQRITLKFCKSHPTSKGMRDFLENHLLDFAKENPGVVVYVKPRRHRTPVMLAEYLNGEKHWVAVKNFESLHIQKWLELMRTQAQDGSAMRLRKMWHTEFPSIQGPWSPFTFMNPISNITKFPDNQLGAAPNQKPTATEILLKMYQAEKNHPTKSIGENIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2EF62</accession>
    <name>A0A8J2EF62_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">isoleucine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Isoleucyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HICCMSTLAB_LOCUS298</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>tRNA(Ile) + L-isoleucine + ATP = L-isoleucyl-tRNA(Ile) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:9666"/>
            <dbReference type="Rhea" id="RHEA-COMP:9695"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58045"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78528"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.5"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.5" evidence="2"/>
    <dbReference type="EMBL" id="CAJNRD030001114">
        <property type="protein sequence ID" value="CAG5073354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2EF62"/>
    <dbReference type="OrthoDB" id="1706657at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004822">
        <property type="term" value="F:isoleucine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006428">
        <property type="term" value="P:isoleucyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000414">
        <property type="entry name" value="Isoleucine--tRNA ligase, cytoplasmic-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.740.10">
        <property type="entry name" value="Valyl/Leucyl/Isoleucyl-tRNA synthetase, editing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002300">
        <property type="entry name" value="aa-tRNA-synth_Ia"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002301">
        <property type="entry name" value="Ile-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023586">
        <property type="entry name" value="Ile-tRNA-ligase_type2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009008">
        <property type="entry name" value="Val/Leu/Ile-tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42780:SF1">
        <property type="entry name" value="ISOLEUCINE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42780">
        <property type="entry name" value="SOLEUCYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00133">
        <property type="entry name" value="tRNA-synt_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00984">
        <property type="entry name" value="TRNASYNTHILE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50677">
        <property type="entry name" value="ValRS/IleRS/LeuRS editing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-tRNA synthetase class Ia" evidence="10">
        <location>
            <begin position="18"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAG5073354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="326" mass="37702" checksum="6D86EEAF771F74F8" modified="2022-05-25" version="1">MREKLPETINFPKEEEKLIEFWTENDVFQNSLRLSKGRPRFSFYDGPPFATGLPHYGHILAGTIKDVVTRYAHQSGFYVERRFGWDTHGLPVEIEVEKALGIKGPEDVAKMGIDNYNKECRSIVMKYSGEWERVVGRMGRWIDFKNDYKTLYPWYMESIWWIFKEMYNKGLVYQGVKVMPFSTGCNTPLSNFESGLNYREVIDPAVFVAFPLKDEEGVSLVAWTTTPWTLPSNLALCCNPNFEYVLVKDNVSKKTYIMLESALSQVYKSDDLYEVVGKRMGSELKGKRYEPPFDYFEHLRAKGAFQVLNDTYVTAETGTGIVHQLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2EGI8</accession>
    <name>A0A8J2EGI8_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS1174</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001116">
        <property type="protein sequence ID" value="CAG5074963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2EGI8"/>
    <dbReference type="OrthoDB" id="6415662at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21261">
        <property type="entry name" value="BEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21261:SF15">
        <property type="entry name" value="BEATEN PATH IIIA, ISOFORM D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="66"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5074963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="381" mass="42454" checksum="5DC8D4EFC626BBD6" modified="2022-05-25" version="1">MFVNLAGECSKFAEVKVPAIVDPREEKVILECNYNLGGEQLYSVTWLKDGNEFFRYMPSAMPGKLQQQHQNSEQNQYKQKQSLSSSRVVDSPAAAAFNVHDGVVQVELSESNDKRVVIRQHLGDKWINVTGSYGCQVSGESPKFDIVYDEAVINVGILPQRDPVIENLREHYDIGETLDAQCISAPSYPTAQLSFLVNGREPSFLRELFIEDESRRSEKLEIKNNNVNNLILKFATSYLEHSFVISAIRLWQKLPVEVLDASTLEVEKSLTTEFPSVGSGVEGSLVSTTRLGLSMSLSDQDFTATSARSLHLVCRSILPGIPGAKARETKAIIYLSASNQKLAQEAPTPFSSRADTNSHHHYKLFLSYTVILALFNFNSVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2EI81</accession>
    <name>A0A8J2EI81_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="11">ATP-binding cassette transporter subfamily G member 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HICCMSTLAB_LOCUS546</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001114">
        <property type="protein sequence ID" value="CAG5073658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2EI81"/>
    <dbReference type="OrthoDB" id="66620at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03213">
        <property type="entry name" value="ABCG_EPDR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000891">
        <property type="entry name" value="ATP-binding cassette sub-family G member"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043926">
        <property type="entry name" value="ABCG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050352">
        <property type="entry name" value="ABCG_transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48041">
        <property type="entry name" value="ABC TRANSPORTER G FAMILY MEMBER 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48041:SF6">
        <property type="entry name" value="PROTEIN WHITE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19055">
        <property type="entry name" value="ABC2_membrane_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="461"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="492"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="536"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="574"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="603"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="688"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="49"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAG5073658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="714" mass="80105" checksum="8CB3C6B07EE5C0AD" modified="2022-05-25" version="1">MKLEGNSSRDDDANGILMQPRKGSVVRVQIVPIQPKTITHLPKRPPVDLAFTDLTYKVREGRKGNEKTILKSVSGRLRSGELTAIMGPSGAGKSTLLNILTGYKSSGMEGSITMNGHERNLSSFRKLSAYIMQDNQLHGNLTVEEAMKVAASLKLSNKVDKAEKEEVIQEILETLGLAEHRRTMTSNLSGGQKKRLSIALELVNNPPVMFFDEPTSGLDSSSCFQCISLLKTLARGGRTIICTIHQPSARLFEMFDALYTLADGKCVYQGSTTQLVPFLRYQGLNCPSYHNPASFIIEVSCGEYGDNISTMVNAIRNGKNDIRDGYPFPDSKSDNLNNALQNGLKDEKSALGVHEMIPMIDKNDASNIKDKFADSKDNLHLNDNHTNSTVIPKYVTNEIAKHGDNLVITVDDKKDNIDVNTSLLDESMVLTPERYPTSELTQFWVVLKRTLLFSRRDWTLMYLRLFAHILVGLLIGALYYDIGNDGGKVLSNLGFLFFNMLFLMYTSMTITILSFPLEMPVLMKENFNRWYSLKSYYLAITISDLPFQTIFCVMYLCIVYFLTSQPVDAMRFSMFVGACLLISYVAQSVGLVVGAAMNVQNGVFLAPVMSVPFLLFSGFFVSFDAIPVYLRWITYLSYIRYGFEGTALATYGFARSKLKCFQPYCHFKEPTTTLEELDMLDADFTLDILALILIFLVLRIAAYLFLRWKLKAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H0F7</accession>
    <name>A0A8J2H0F7_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similar to Fas1: Fasciclin-1 (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS2022</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001116">
        <property type="protein sequence ID" value="CAG5076041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H0F7"/>
    <dbReference type="OrthoDB" id="7700931at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.180.10">
        <property type="entry name" value="FAS1 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036378">
        <property type="entry name" value="FAS1_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000782">
        <property type="entry name" value="FAS1_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02469">
        <property type="entry name" value="Fasciclin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82153">
        <property type="entry name" value="FAS1 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50213">
        <property type="entry name" value="FAS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAS1" evidence="1">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5076041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="88" mass="10428" checksum="6772CDA2784BF0E4" modified="2022-05-25" version="1">MSLLFLVVEFSQVKKMILESKNLVLGILNRGSTYMLGQRRNFNDRLSEPKKRYTYFVPRNSAWEKAKNIFPSAYKKIFMPDFSYHVSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H1J2</accession>
    <name>A0A8J2H1J2_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Pre-mRNA-processing factor 17</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Cell division cycle 40 homolog</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">PRP17 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">HICCMSTLAB_LOCUS633</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001114">
        <property type="protein sequence ID" value="CAG5073845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H1J2"/>
    <dbReference type="OrthoDB" id="10257301at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000034">
        <property type="entry name" value="Pre-mRNA-processing factor 17, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032847">
        <property type="entry name" value="PRPF17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43979">
        <property type="entry name" value="PRE-MRNA-PROCESSING FACTOR 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43979:SF1">
        <property type="entry name" value="PRE-MRNA-PROCESSING FACTOR 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="2 11" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="272"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="316"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="402"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="502"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="534"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="194"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="19"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00068146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00075265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00076678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CAG5073845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="567" mass="64665" checksum="3BA0DBBFD1FF7A6D" modified="2022-05-25" version="1">MLALQGYNSSDDEGPVDTQVETSNNDKINSENSVAISMKICAAPDVVPTGTELCVRHVDSTVSELPYNPKYDELFAPEVGPTNPFKTQQQRAPKNILSGYVEKAVISDFQFENQRRTFASYGYALDPTIDGSAEEGRTLIGSPSVAEENNSKTVFERTELRPADKRKRHRNDDPQDIAGFLGPWGGYVDEKKVMKPTEEEAAELEEILAKKNKRGKQVEEKPLEEKTVLHIKDPLDYQGRSFLHAPQDVGVNLRSDSPPDKCFLPKSQIHTWEGHTKGISQIKWFPKTAHLLLSCSMDCRVKLWEVYKDRRCVRTYYGHRQAVRDISFDNDGSRFLSAGYDRYVKLWDTETGACISRFTSRKIPYCVKFNPDHDKQHLFVAGTSDKKIICWDTRSGEITQEYDRHLGAVNTITFVDENRRFVTTSDDKSLRVWEWDIPVDMKYIADPTMHSMPAVTPSPNQKWLACQSMDNKIVIFSALNRFKMNRKKTFTGHMVAGYACGLDFSPDMSYLVSGDADGKCYCWDWKSTKLFKKWKAHDGVCISTLWHPHEPSRVATAGWDGKIKYWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H2V9</accession>
    <name>A0A8J2H2V9_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS75</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030000535">
        <property type="protein sequence ID" value="CAG5071611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H2V9"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5071611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="90" mass="8997" checksum="79F6B33FDADEFFEF" modified="2022-05-25" version="1" fragment="single">MHRGGGIGGGGGPGTTAGRGLELEPPSTIPTAPASFHWGAMIAGHHAVAAASMMQPSLTGTADYSLATTHSAAHATIPMDLHMSQGFPCY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H445</accession>
    <name>A0A8J2H445_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative Tryspin-1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HICCMSTLAB_LOCUS2101</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001116">
        <property type="protein sequence ID" value="CAG5076120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H445"/>
    <dbReference type="OrthoDB" id="10012881at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000006">
        <property type="entry name" value="Serine proteinase stubble"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033116">
        <property type="entry name" value="TRYPSIN_SER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24252">
        <property type="entry name" value="ACROSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24252:SF7">
        <property type="entry name" value="HYALIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00135">
        <property type="entry name" value="TRYPSIN_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 5" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0720">Serine protease</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035184078" evidence="6">
        <location>
            <begin position="21"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="7">
        <location>
            <begin position="152"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG5076120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="388" mass="42711" checksum="0E5B2865817563DD" modified="2022-05-25" version="1">MNKYAITVINLLVCVSVVYSNVNYPKLLSGYSNKNWNNQRVSYNHANAHPNANNQDNYNVNNYNDNGNKDVDSAGLMGKIFARGFKKSPSDLVDLGLVTSKKNQDLEKKLGTTQRTFVEWIQNIVGTTTTVASIPKECPKCSCGTSSTPNKIVGGHDAGMDQFPWMAYLTYGGKFYCAACIISDRFLLTAAHCVDRFDTFKMMVHVGDFERGNKTSKSTAYRVESVIKHSGYSLLNYNNDIALIKILGRMKFDGPLKPVCLPERGSTFAGRNASVTGWGAIEESGALATKLQEVVVPILSNNECRGTKYPPKRITDNMLCAGFLDGGRDSCQGDSGGPLHILEDNTYHVVGIVSWGEGCALEGYPGVYSRVNRYITWIERSTRGSCFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H5I1</accession>
    <name>A0A8J2H5I1_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Similar to Ank2: Ankyrin-2 (Mus musculus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HICCMSTLAB_LOCUS845</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001114">
        <property type="protein sequence ID" value="CAG5074073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="20872at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.220.30:FF:000009">
        <property type="entry name" value="Ankyrin 2, isoform G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.20:FF:000003">
        <property type="entry name" value="Ankyrin, isoform B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.20:FF:000001">
        <property type="entry name" value="Ankyrin-2 isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.220.30:FF:000001">
        <property type="entry name" value="Ankyrin-3 isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.220.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2660">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040745">
        <property type="entry name" value="Ankyrin_UPA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051165">
        <property type="entry name" value="Multifunctional_ANK_Repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000906">
        <property type="entry name" value="ZU5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24123:SF141">
        <property type="entry name" value="ANKYRIN 2, ISOFORM U"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24123">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13857">
        <property type="entry name" value="Ank_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17809">
        <property type="entry name" value="UPA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00791">
        <property type="entry name" value="ZU5"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="24"/>
    </dbReference>
    <dbReference type="SMART" id="SM00218">
        <property type="entry name" value="ZU5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="19"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="19"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51145">
        <property type="entry name" value="ZU5"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="7">
        <location>
            <begin position="49"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="7">
        <location>
            <begin position="82"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="7">
        <location>
            <begin position="115"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="7">
        <location>
            <begin position="148"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="7">
        <location>
            <begin position="206"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="7">
        <location>
            <begin position="239"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="7">
        <location>
            <begin position="272"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="7">
        <location>
            <begin position="305"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="7">
        <location>
            <begin position="338"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="7">
        <location>
            <begin position="371"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="7">
        <location>
            <begin position="404"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="7">
        <location>
            <begin position="437"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="7">
        <location>
            <begin position="470"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="7">
        <location>
            <begin position="503"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="7">
        <location>
            <begin position="536"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="7">
        <location>
            <begin position="569"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="7">
        <location>
            <begin position="602"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="7">
        <location>
            <begin position="635"/>
            <end position="667"/>
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            <dbReference type="SAM" id="Coils"/>
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            <dbReference type="PROSITE" id="PS51145"/>
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            <dbReference type="EMBL" id="CAG5074073.1"/>
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    </evidence>
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    <sequence length="4016" mass="448901" checksum="A51ECCD3CDE99E9C" modified="2022-05-25" version="1">MIMTTEYPPIITLETDDTTAFLRAARSGNLEKVIEYLDLNLDINTSNSNGLNALHLASKDGHVEIVTELLKRGAKVDSATKKGNTALHIASLAGQVEVVNILLQYGAAVNTQSQNGFTPLYMAAQENHDQVVKLLLTNGANQSLATEDGFTPLAVAMQQGHDKVVSVLLENDSKGKVRLPALHIAAKKDDCKAADLLLQNDHKPDHNISPLHVAAKWGKNNMVKLLLENSAMIEAKTRDGLTPLHCAARSGHEEVVSTLLEHSAPISARTKNGLAPLHMASQGDHVDAARVLLYHRAPVDEVTIDYLTSLHVAAHCGHVRVAKLLLDRKADPNARALNGFTPLHIACKKNRIKVVELLLKHGASIESTTESGLTPLHVASFMGCMNIVIFLLQHEANPDVPTVRGETPLHLAARANQTDIIRILLRNGAKVDARAREEQTPLHIASRLGNVDIVMLLLQHGASVDTTTKDMYTALHIAAKEGQEEVAAILVENHASVKALTKNGFTPLHIAAKYGNVNVAKILLQKDSKLDSQGKNDITPLHLACHYDHSNVANMILEKGASPNLASQNGHTPLHIAARKNQMDIASTLLEHGADPNAQSKAGFTPLQLSAQKGHYDMTNLLIEHGADPNHKSKNGLTALHLCAQEDSIRVASILVKNGANVESQTESGYRPIHVASHFGNLSMIRFLLKHNAQIDVRTSHNYTPLHQAAQQGHAHIDGLTALNIAQKLGYISVMEVLKGLDYDTQTPDNKTWEEKYKVIAPESLQETCFMSDSDDEGDGLTNEQPYRYLTADIMKSLRDDSLPIDVTRDDPIHRQLSHEEKQEFTQSSNYCPPENFDSTDAINVGRLHFRSFLVSFLVDARGGTMKGCRHSGIRIIVPPGRATMPIRVTCRLLKPSKVANPPALMEGEALATRIIEMGPVGATFLGPVLIDVPHFASIEGKEREIIIMRSENGETWKEHDNSRDNDDTLFNTAHDTQMSNSHPGRITRIITTEFPQYFAIITRIKQEVHVIGADGGILISSVANHVQAVFPPGALTKKIKVGLQAHVIPAELTAKLLGNCVAVSPVITIEPRRRKFHKPITLTIPVPQAANKGMINEYGGETPTLRLLCSIAGGTSEAQWEDVTGSTPLTFLNNRVSFTTTVSARFWLMDCRNISEVPKMATDLYKESLFVPFITNFVIYSKRFDVVEATLRILCMTDGKDGLHTLEKQEEFLEIVKSRDVEALDGKDLYLEFSGNLVPVTKSGQQLKFTFKAFRQNRLSFHVKVKDQLLDPVARMMFMREPKVAKGEIAQQPICILNIVLPEPTVPKTPSNSKLKELEYDFISKMDIYKTTYMRDYGEKRDLPKPTSPTQQKLINAEINESLAQKVACPLESVDGSYPNNINDSNINNKEELLSPNLEKQTYSEKRKFWEDITRKRDSYQRSESEISRASQMTINESDSDYLQNPISEEEMDNMFDSAMHSETMEDLNIPDMSECSVAEKAHYFEEQIQKEITATGVSRPLSKLMSQESLPRDKRFSTDSSVCEQFKDKDLSPDVKKVEQDAGKNLVGKVDQEKSEDKLPTEGTGKEEMIKEEGDLKLGRLETEESYERGLKEEKEVKSDDKLPTDKEEIKKQDNLRLEGIKTVEIHEKVLIKEKEVKVTHKDDQERIKSKDKLLAEVTGKKEEDEEQDLRLETLKDVESHDKLSIEKQQVKITDSLVGKHDQEEIKSEDKLPIDKKEIKQQDNLKLETVKTVESHEKVLIEEKEVKIAHKDDQEKIKNEDKLPTEAIDKKEEEKEHDLESETFKNVESTDKVLREEKEVTIGYEDDQEQVKSEDKLPTEVSSNKEETKEGFKVVESIDVLEEKEVKIADKLIGNKEEMKNEDKLVADKEELKEQDFELKTTKTEESIERLLTEKEVKKITETSKEDESVKTEESDLESKKETKVTIDDLVEQHVKPEVLQVSDAKPSLIPRKIKSEVTTTTSIEPDKVKTVEKKVVSIEETRVIADDSINTKQICREFIDSEVKLTHQGSDAAKVSPEEKVSKIPTKIRVDSFVEADKEKENGKKESKIPVFGSKDANKGVKPKEEDLKDTEDKKKKSGIPKRIEITKFEKFPLKDDGVTVMETKVTEKVSQRIETHTSEREIHSQTITKTFTDPEEALRAFEGAEALHEPDSLVTTSKVDHEKMVTVEKKEIKSSELVFGDEKTVKHEEKERELKEKSSESTVTTETQEETVEDKTLKHETADKSTIQDIEVNLAGGKQIVDARASQELKSLKDQINIHKVEDDDGVVIQEAGIKTLKEHAIDTAVRIEKDRSNDMEDMSSLGRSLEDELKAAVIHEQTHEESSRHSDTKVFPSRETTEDISRDEAFGEEFNDNSEETDEASEIEARDIAENLVQSIEDELVKRSESSSGLKMGYEFDNVNETDEDFDEHLADDLTKKFENIMGKRKESQVQVIESLDQIRATFIGHNERLDKDSTRGSLSIEEDLTKDEDSTPHDREESFLSSSSQKIMERDITMSPSSISEQIDLESLSSGQQAGQSPMPVVEYPEELKVVEEYFEQPDEYVSPMKFGYENTGARVLEIIEPGGDLRRGSRQDSVDVSSLEIDELRFEDDEEEHSLDEKYMKNLEFAKLHESPGMEALDKIGQERDLTFSPSSMSDSSLVPERSLSPKAKSGIESEDGGFSSMEPERTEVEKVSRLDTKSIDRDLKPAVVSPRTKLKELDIKPVDWSIGDEKIEIQETLEPSQAFDKELEEYQSSMVKQQSLTSLNDVSAEQESTTRSSEDVSTIESVKEASKIVVESVSEMDDEELVEDKLDISCQELVASLHRQYEERTPTDEIGVSESEKDVVDEKKVEIEDKVEVAEKAKTKVEKSEQDEKDIDTLEESEKEGKESQAKALKESFYSKTKSLDEPQKHLERTLNREKFAGMSMDSSPFRLKKEANVDLSARYAITVLDQVVKREIEEVKESLEAAKQDLIEELSENSETIVQIKESPSEFQFKLEPESIPNDLPFLYKAPSFEQPAEDLSGSPVAKPRKQEDTLDDESVSEKPLSDNDTLSELPSDKTMEVKILEDDFEKLPVAASRSGSDAEYFDGSSSLSVPPQPIPRKRQKPARISKKIQSESEGGSSSGESSNYQSCDYETSSRPSSSDIEVLHTASGFLSATASEYETAMMSLESSKQTSQDYQSAVSTLSSRESMKSLNSLSSGHLGSIDSTSELTETLVASEPEMDKDEIDENLELALDDDKSSGSSESDMPLDDTLDNITGDIPSKMKRSSEMIFQQISEDADTIPEGEGSTAEEGQSTKVTSSIMISEDDDLKTSTIDAISEQISGKAEEDTSSPEVKLKSIEAQSTGDDIDSSELKMSSLSTIDEVENLLLTKRSVLQQASMSTSSTSGVSIETVVERDRHSPDSDSFELVDKPDIIDDFVVVEEVGREAEEFDSEGKSILIKPIPAGSLKKFDRDLENLITETKQEAPVSQALLKNELFDFESEESPPQASNEDQSSQQSFSDDEQEAKKWMEMQFTGDPRGYELEYDRGPLEDIKEEEVTDFEAGSSRFGSLGSHKGSIGSSGSMKGSLGTEYDILAGKKMFSKSIEHDNISMNSLQEFESLENTVIGENGKRIYCGSQDSVNNGSLPRRYVASRSGHGDDVSVSSLTDFEGLEKACKEAHIIELKAKEEEDLLDHESPENRYRLENLPKPKPADLSAAGSFNPSTSGSDDYEKRIMEIDEIIRIAQANVEKFDRQDDTTEDISQIDMTDVEKIEPIAVQGQVSEVNVNVMETSTDSLEIEDDKHNNLMCRSSDSLELKTTIDYPSLSYSDSLNNVRDSQDPYAGDQFNSSRRISSDSLEVQVLEHPEERNTEGKKKINFLITISVKLRIKSMKLPIHLAVENDQFNAVAALFNKNKDSIHHQDDCNRTPLIPFLHRAVQFEQLEIVKLLIAKKVNVNAVSGAKETALMVAAYYNFTVIADFLLKNKANPDLENENNLTALDIAIMANNYETFCLLVKSFKVQVTNQTSNEFRPLHVAAIHGRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H5L9</accession>
    <name>A0A8J2H5L9_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Serine/threonine-protein phosphatase PGAM5, mitochondrial</fullName>
            <ecNumber evidence="3">3.1.3.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Phosphoglycerate mutase family member 5 homolog</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Serine/threonine-protein phosphatase Pgam5, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HICCMSTLAB_LOCUS2340</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Displays phosphatase activity for serine/threonine residues, and dephosphorylates and activates Pk92B kinase. Has apparently no phosphoglycerate mutase activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="7">Interacts with Pk92B/ASK1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="3"/>
    <dbReference type="EMBL" id="CAJNRD030001117">
        <property type="protein sequence ID" value="CAG5076983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H5L9"/>
    <dbReference type="OrthoDB" id="2118094at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090141">
        <property type="term" value="P:positive regulation of mitochondrial fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051021">
        <property type="entry name" value="Mito_Ser/Thr_phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20935">
        <property type="entry name" value="PHOSPHOGLYCERATE MUTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20935:SF0">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE PGAM5, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00039765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00040722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00042520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAG5076983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="386" mass="43512" checksum="F9B2C15A6ADFE2ED" modified="2022-05-25" version="1">MSKFSRFQKFAAVLGVGTVSGAAAIYYNGYVSPKEQYESPYNNTPKFPGVGELTPSIKWDSNWDRRDPKSLIKPKKLEAITDENKYNAEIEAHKPRAARHVLLIRHGQYNLSGSTDTQRILTELGRNQADCTGKRLQHLALPYSQLVRSTMTRAQETAKIIETSLPNVPVVDDSLLVEGCPILPEPPFGGWRPGIQYFQDGPRIEAAFRKYFHRASPKQEKDSYTIIVCHANVIRYFVCRALQFPPEAWSRFSLKHASITWISIQPSGRVVLRGYGDAGHMPSEEGSEFQRKKKHFFCDFLSQISRDPENDPELGDQGVQQVGVQGVQQVDVQGVQQVGPDGLGRYVAPIANPPRIDEVQQRGEIENHRTNCLTCRQLILISETYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H7E0</accession>
    <name>A0A8J2H7E0_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Similar to Flo1: Flotillin-1 (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HICCMSTLAB_LOCUS3402</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the band 7/mec-2 family. Flotillin subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5081883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H7E0"/>
    <dbReference type="OrthoDB" id="6080404at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016600">
        <property type="term" value="C:flotillin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002020">
        <property type="term" value="F:protease binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901890">
        <property type="term" value="P:positive regulation of cell junction assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000049">
        <property type="term" value="P:positive regulation of cell-cell adhesion mediated by cadherin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045807">
        <property type="term" value="P:positive regulation of endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070528">
        <property type="term" value="P:protein kinase C signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072659">
        <property type="term" value="P:protein localization to plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002090">
        <property type="term" value="P:regulation of receptor internalization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03399">
        <property type="entry name" value="SPFH_flotillin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.479.30:FF:000003">
        <property type="entry name" value="Flotillin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.30">
        <property type="entry name" value="Band 7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001107">
        <property type="entry name" value="Band_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036013">
        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031905">
        <property type="entry name" value="Flotillin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027705">
        <property type="entry name" value="Flotillin_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13806:SF46">
        <property type="entry name" value="FLOTILLIN-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13806">
        <property type="entry name" value="FLOTILLIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01145">
        <property type="entry name" value="Band_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15975">
        <property type="entry name" value="Flot"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00244">
        <property type="entry name" value="PHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117892">
        <property type="entry name" value="Band 7/SPFH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Band 7" evidence="5">
        <location>
            <begin position="87"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU366054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAG5081883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="427" mass="47280" checksum="37CD901DE4DA9441" modified="2022-05-25" version="1">MSCGFVTCGPNEALVVSGCCYGKPLLVPGGRVFVWPVVQQVQKISLNTMTLQVESPTVYTCQGVPISVTGIAQVKIQGQNEEMLSTACEQFLGKNEDEIHNIALVTLEGHQRAIMGSMTVEEIYKDRKKFSKEVFEVASSDLVNMGITVVSYTLKDIRDEEGYLKALGMARTAEVKRDARIGEAEARRDAQMREAIAEEQRMASRFLNDTEIAKAQRDFELKKAAYDVEVQTKKAEAEMAFELQAAKTKQRIMEEQMQVKVIERGQEIAVQAQEMVRRERELDATVKRPADAEKYRLEKMAEANKLRLVMEAEAESEAIRIRGEAEAFAIEAKAKAEASQMAKKAAAWNEYGHAAMVDMMLETLPKVAAEVAAPLSQAKKITMVSNGSGSIGAEKLTEEVLNIVTRVPELVKTLAGVDIAKVIFNYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H7M4</accession>
    <name>A0A8J2H7M4_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">L-lactate dehydrogenase</fullName>
            <ecNumber evidence="3 7">1.1.1.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HICCMSTLAB_LOCUS3606</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>(S)-lactate + NAD(+) = pyruvate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23444"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16651"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 7">Fermentation; pyruvate fermentation to lactate; (S)-lactate from pyruvate: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the LDH/MDH superfamily. LDH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.27" evidence="3 7"/>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5082602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H7M4"/>
    <dbReference type="OrthoDB" id="5405561at2759"/>
    <dbReference type="UniPathway" id="UPA00554">
        <property type="reaction ID" value="UER00611"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004459">
        <property type="term" value="F:L-lactate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006089">
        <property type="term" value="P:lactate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05293">
        <property type="entry name" value="LDH_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000018">
        <property type="entry name" value="Malate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.110.10">
        <property type="entry name" value="Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001557">
        <property type="entry name" value="L-lactate/malate_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011304">
        <property type="entry name" value="L-lactate_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018177">
        <property type="entry name" value="L-lactate_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022383">
        <property type="entry name" value="Lactate/malate_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001236">
        <property type="entry name" value="Lactate/malate_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015955">
        <property type="entry name" value="Lactate_DH/Glyco_Ohase_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01771">
        <property type="entry name" value="L-LDH-NAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43128">
        <property type="entry name" value="L-2-HYDROXYCARBOXYLATE DEHYDROGENASE (NAD(P)(+))"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43128:SF16">
        <property type="entry name" value="L-LACTATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02866">
        <property type="entry name" value="Ldh_1_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00056">
        <property type="entry name" value="Ldh_1_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00086">
        <property type="entry name" value="LLDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56327">
        <property type="entry name" value="LDH C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00064">
        <property type="entry name" value="L_LDH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0520">NAD</keyword>
    <keyword evidence="4 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactate/malate dehydrogenase N-terminal" evidence="8">
        <location>
            <begin position="52"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="Lactate/malate dehydrogenase C-terminal" evidence="9">
        <location>
            <begin position="193"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="domain" description="Lactate/malate dehydrogenase N-terminal" evidence="8">
        <location>
            <begin position="366"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="domain" description="Lactate/malate dehydrogenase C-terminal" evidence="9">
        <location>
            <begin position="513"/>
            <end position="653"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAG5082602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="663" mass="72543" checksum="26AB1B1CB22ABD63" modified="2022-05-25" version="1">MQTGCVVWSITLLTCLNFRDSRKEWIRIDKMTTLKEKLLSVVKEPSGNGKNKITVVGVGQVGMACAFSILTKYVSSDVVLIDVMADKLKGEMMDLQHGSAFLKNSRVNASTDYAASAGSSICIVTAGARQREGETRLDLVQRNTDIFKGIIPQLVKHSPNCILLIVSNPVDILTYVAWKLSGFPKNRVIGSGTNLDSGRFRFLLSQKLGAAPTSCHGWIIGEHGDTSVWSGVNVAGVRLRDLDPRVGTKDDPENYGDIHNQVVSSAYEVIKLKGYTSWAIGLSVANLASAMLRNSGQVHAVSTMVKGFHDIEEEIFLSVPCILSLDGVTSVVQQKLTEDEKGLLPNSLREGLLCRVKTPSIDSIDKVTIVGAGMVGVACANAILFQESNFQKISSHVAIVDAFPKKLEGEGMDYCHSSVFLDDPYIEYDTDFCVSSNSKVVIITAGARQIKGETRLELVQKNVNIIKNIVPPLVQYSPNAVFLVVTNPVDILSWVTWKVSGLPYNRIIGSGCHLDSARLRSLISERLGVASKSINAFIIGEHGDSQVPLWSGVNVAGVLFRDIMPTIGLEMDQEGWSELMTDNVKAQVEKLATFSLIALTLIENLFEQGHHGIHHEMFLSLPCTLGENGVSQVIRMRITEHEKKLFQKSAEIVYNIQKGLKIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H7V8</accession>
    <name>A0A8J2H7V8_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Similar to MFSD6: Major facilitator superfamily domain-containing protein 6 (Sus scrofa)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HICCMSTLAB_LOCUS3543</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. MFSD6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5082370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H7V8"/>
    <dbReference type="OrthoDB" id="515887at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024989">
        <property type="entry name" value="MFS_assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051717">
        <property type="entry name" value="MFS_MFSD6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16172">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 6-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16172:SF30">
        <property type="entry name" value="SUGAR BABY, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12832">
        <property type="entry name" value="MFS_1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="16"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="40"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="74"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="260"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="300"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="332"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="377"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="414"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="445"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="507"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="535"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="376"/>
            <end position="595"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG5082370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="595" mass="66663" checksum="4FB649E7FE9D481E" modified="2022-05-25" version="1">MLEKINKELVPIKAHYFLYNAATGPIIPFLPVIAKQLGFSGFLVGIIYTILPISGLLAKPLFCSIAEKFNLHKIFFLTFQAILAISFFSIYFIPKINHQSIGNVTLACHAETYLHICPYNTSDRFSDEALNQASVSNTTHSSCKLACQGSSEAFSELCHGWQLNQFCGLVNANMEPDTKFEFTAGFNIDDNQNIMSCLHVKIKNATFDDDKPVHPFCDVKDKPMYTQCMANCTDVPEMKKIFNELNGKDTHLTTNYQFHLFLWSCVVSWIGMAVVTSIADSICNDILGNERINEFGKQKLWGYIGFGIFCISTGYLVDLFSRGIPDKDYSCIFYIMLVGMIFDIIVSGTLDKKSVDRTDDDPSVLWELGAVAREGRVLVFIFWCVGAGICTGVVWNFLFWYTEDIATNKDWLKTLQGLLIGVQYFLGELPFNFISARVLKKLGHINVMSLVLIIYAVRFMAYSLITNPWIYILVELLHGPTLGLCRPTMIAYGDKIAPSGTRATMQGLVGAIFEGIGVSIGSLICGRLMDDYSGMLTFRIFSVGALSWLSIYWMLQLLLRKAKAYPLHQGHSHLASYATPSDAILMTTSQELQTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H7Z1</accession>
    <name>A0A8J2H7Z1_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Similar to Pard6g: Partitioning defective 6 homolog gamma (Mus musculus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HICCMSTLAB_LOCUS3834</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5083420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H7Z1"/>
    <dbReference type="OrthoDB" id="5868434at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007098">
        <property type="term" value="P:centrosome cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06718">
        <property type="entry name" value="PDZ_Par6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.42.10:FF:000030">
        <property type="entry name" value="Partitioning defective 6 homolog beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051741">
        <property type="entry name" value="PAR6_homolog"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053793">
        <property type="entry name" value="PB1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000270">
        <property type="entry name" value="PB1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14102:SF11">
        <property type="entry name" value="LD29223P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14102">
        <property type="entry name" value="PAR-6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00564">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00666">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54277">
        <property type="entry name" value="CAD &amp; PB1 domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51745">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PB1" evidence="3">
        <location>
            <begin position="14"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="2">
        <location>
            <begin position="156"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="258"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="306"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="266"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="312"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG5083420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="341" mass="37332" checksum="437205B3D980A1AC" modified="2022-05-25" version="1">MSKSKLHHHVDSNIVAVKSKFDSDIIRFSINKKNPIGYDEFRKLLAEKHELNKDDKDKSFNIRYTDPTDNDLLPINNDNNLARALLAAKSLLKILITRNGDSFDENTGTLKPKNLISSILGGTPGKPKSLAISNPHDFRQVSAIIDVDILPATCRRVRLLKHGSDKPLGFYIKDGESVRVLPPSAGGGFEKVPGVFISRLVPGGLAESTGLLAVNDEVLEVNGIEVAGKTLDQVTDMMIANSSNLIITVKPANQRAAMAAPRRGSFSRNSQLSSGSHQSTQSIVTGSASDEEADEIVDLTGVALHDDIPTSSHHHHHHHHHHHQHHQPHNHFNDQPGVLHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H8K5</accession>
    <name>A0A8J2H8K5_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="14">ATP-binding cassette transporter subfamily C member 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">HICCMSTLAB_LOCUS3967</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5083918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18579">
        <property type="entry name" value="ABC_6TM_ABCC_D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03250">
        <property type="entry name" value="ABCC_MRP_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03244">
        <property type="entry name" value="ABCC_MRP_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000973">
        <property type="entry name" value="Multidrug resistance-associated protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000026">
        <property type="entry name" value="Multidrug resistance-associated protein lethal(2)03659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000014">
        <property type="entry name" value="Multidrug resistance-associated protein member 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000163">
        <property type="entry name" value="Multidrug resistance-associated protein member 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044746">
        <property type="entry name" value="ABCC_6TM_D1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF456">
        <property type="entry name" value="MULTIDRUG RESISTANCE-ASSOCIATED PROTEIN LETHAL(2)03659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="80"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="128"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="208"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="233"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="328"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="358"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="766"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="833"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="922"/>
            <end position="946"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1006"/>
            <end position="1038"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1045"/>
            <end position="1065"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="13">
        <location>
            <begin position="105"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="12">
        <location>
            <begin position="469"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="13">
        <location>
            <begin position="774"/>
            <end position="1073"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="12">
        <location>
            <begin position="1133"/>
            <end position="1365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="713"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="713"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="732"/>
            <end position="742"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CAG5083918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="1389" mass="156265" checksum="5D0936A489929374" modified="2022-05-25" version="1">MDATKTTTNPNPREKANFLSVLFWTWTLKLFRTGYSKILEPEDLFDPLKIDRSSVLGDRLEKQWNLELESTKKSKRRPNFLKTIFRCFAWEYFMFGILHTFNEFILRLGTPLLLGQLLRYFRGTGGSYYNDALMYAGGICLATGINAITLNQSIFGAFHLGGKIRIAVCSVVYRKALRLSTTALGETAPGKIVNLVANDVNRFDLVSIFLHHMWSAPLTTIIIGYFLYTEAGYAGILGIGAVFIVVPIQSYTGKLSSKFRLQTAIKTDERVRLMDEIISGVQVIKMYAWEKPFCTMIALARKLELKVVQKNSWIRGIFMTFNLFTTRVAIYCTLVGMLFFGQQITAEKAFVFSSLFNILAHTMSAMFVRGIAEIAECIVAVRRLQYFLMYDEVENVNRTVYSGRLSVDHGSIGVNNKLSSSTKFDLPYIDDESNDVTSDTINTKLIRHNEPTSVPQNKHQNDKNKSWAVKLTNVTTKWEPSNPENTLQDINFKLERGKLYAIIGAVGAGKSSLLSAILGELPLMQGSVELKGGLSYAAQEAWVFGSTVRQNIIFGEPYDRQRYQRVVKACALLSDFKQFPQGDQTIVGERGSSLSGGQKARINLARAVYRQVDIYIFDDPLSAVDTHVGKHLFEECIQYYLAGKTRVLATHQLQYIKSVDGILLMEHGTVRLFANYMDLLAICPDYSTLLASDSTSENDESLSLSAEKISMRRQWSSASNRSRTPDQSGGDTDVEDDEEENEVINNIEGTSRGVIKGSIFMKYFRSGANICFVIMVGILFLLTQGAASLNDYFVQILVNEEETRYVEHLTKSSNNTDEPAVNQYDITPAFPYVYAYTGIVLSVFVIGITRSLSFYALCVKASQRLHDWSFEALIRTSMRFFDTNPSGRILNRFSKDMGAIDELLPKALLDAGQIIMMMVGSLVIVCVVNPIFIVPLVIIAFIFYWIRKVYLKTSKNVKRLEGMMRSPVFTHLNTTLNGLSTIRAYGAQNILKKEFDNFQDSHSSSWYMFITTSTAFGFSLDLFCFLFTAIVTFSFVLIDMGISGAEVGLAITTVMSMTGMIQWGMRQGAEVTNQLMSVERVLEYTLLPPEDNVFDEKQMLKKTKAKTSKKKGILVEEKIVNHSPESWPTEGCIKFHHVYMRYVEEDPPVLKGLNIVIKAKEKVGIVGRTGAGKSSLISALFRLAKVEGVIEIDGIDTGSIYLEDLRRNISIIPQDPVLFSGTLRKNLDPFNEFKDEALWSALEEVELKDSFAMVNGLDSRVFDRGTNFSAGQRQLVCLARAILRNNKVLMLDEATANVDPHTDGLIQRTIRTKFSECTVLTVAHRLNTIMDSDKVLVMDKGRMVEFDHPCILLKNDHGHFTSLVKQTGRAMTDQLMRIAKQAYDNKLNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H8T8</accession>
    <name>A0A8J2H8T8_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS3280</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5081415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H8T8"/>
    <dbReference type="OrthoDB" id="187712at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5081415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="110" mass="12179" checksum="8944D80BE4D99E00" modified="2022-05-25" version="1" fragment="single">MMYHKPTVPRFRIAERICTNRPVSRNISYEHESNCSFIISASNSSINRSGKSHVGSKGPSPHPSTPNRSGIQSPKPTLNGTNLISHNSSATSVYESRIQESHYDTVKPLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H9G6</accession>
    <name>A0A8J2H9G6_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Similar to Ncoa5: Nuclear receptor coactivator 5 (Mus musculus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HICCMSTLAB_LOCUS4591</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5087726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H9G6"/>
    <dbReference type="OrthoDB" id="10044938at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="entry name" value="Anticodon-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052600">
        <property type="entry name" value="Nuc_rcpt_coact/corep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23295:SF6">
        <property type="entry name" value="NEOSIN, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23295">
        <property type="entry name" value="NUCLEAR RECEPTOR COACTIVATOR 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0675">Receptor</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="18"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="85"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="578"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="92"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="119"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="143"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="170"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="218"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="260"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="578"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAG5087726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="629" mass="67315" checksum="A4F77FD348723BC5" modified="2022-05-25" version="1" fragment="single">NIVKMAARLLKDPATANCRVFVGHLQSEDISKMEFEQHFSKYGMVIGSLINRGFGFIQYENESSAQAAIQNENGQMFKGRRIDVKPAKKDSSGGGGGGGGGGGGDQKNNFSSPRGGGNQSFNQKNTSFNNLNCDTSFDDNDNKNSGNSGHDGFNSNDNNNPDDDNVNEYQQFNSNQNDSFNNGNSGGNQNRPGNNNNNNNNNNNNNNRNQGQANPRQRGTRGGKNRNKNRAGGGDNSGNFRDRSPLNRGPMNRGPGGPGNDDKNNRGDWGDHNMMRNNFNRDNFNDNNRFDDRFKDPMGMGGGGPGLGMGLGGPGMGLGNPGLGGLGGSGPGLGGPGPGGPGNFGRMGGPSDFPMPQAAPTMEKNDCEIIVVHKNLTEYAEAIEARLKKMGLTVDLLFPNEEVPLSRVLGNIANRGCLYAVVIMPINMEHHSLTLNILHGLPQEHRNMPTEDALALIGRDFSNYKSGSRGVPFNTPFASDRHPDAIQVLLNMLADNHQLTVSQYERVIKYLEVKREEQVQVELGDAKDLAGNSLAANDPKQAELQSRILNILNSNKTNAPVPSPVPAPAPVPAPLLPVPTTVTSSSTSTTGTAAVTPSPLLNDPTVQKALDSLLQGNLLKTDRPIAYFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H9P6</accession>
    <name>A0A8J2H9P6_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Similar to RF_0381: Putative ankyrin repeat protein RF_0381 (Rickettsia felis (Strain ATCC VR-1525 / URRWXCal2))</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HICCMSTLAB_LOCUS5118</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5089135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H9P6"/>
    <dbReference type="OrthoDB" id="341259at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="69"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="103"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="471"/>
            <end position="498"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAG5089135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="508" mass="58414" checksum="82AB8AFB59BF4F8D" modified="2022-05-25" version="1">MDPETIAKKRRELRREGLDVDKHNLCDAIDKYRLAVCQAISNHQMGQNNSFFEDQIINNAPIETTGPFAGYTALHIACMNGNEEFIRLLVEDYHANVNAVADDGAQPIHFACLFELVMPEKLIDILLGAGANVDAEIGEKLFTIYIKNDKWCNDFGNKMTLLTFSILYANNDSFVISLIEGKANLKVKSLKNKTLLMYAIENQNKTIVSSLIKEVHDHEWINARDSDGYTAAHYRLHKHKIENDPNFDKHNLLYCFFDDLRSAELIHELLNAGADVNATVNDDPNTLLLNIAARKHYPCTLDKLLAYHDNISKSMALHYSLCPLKSSQTTFDIIKQKASIILTLKDLIHRRTFGLFVPEDEKILMDKLIAEDIHFRELAHTYEQNIIQGKLKTEVLKYDDKSITYYDFIMSCFDDKKLHLIVKNKSLLDAFENIFPNPDLPSPVLDDVFDLHINSSYAVKVFYTADYFFFRKKISNRIEKTSRRLEQLEALRKVENLRKAIPLPYELT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HA38</accession>
    <name>A0A8J2HA38_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similar to 1-phosphatidylinositol phosphodiesterase (Bacillus thuringiensis)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS3767</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5083212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HA38"/>
    <dbReference type="OrthoDB" id="7697653at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051057">
        <property type="entry name" value="PI-PLC_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000909">
        <property type="entry name" value="PLipase_C_PInositol-sp_X_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13593">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13593:SF113">
        <property type="entry name" value="SI:DKEY-266F7.9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00388">
        <property type="entry name" value="PI-PLC-X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00148">
        <property type="entry name" value="PLCXc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50007">
        <property type="entry name" value="PIPLC_X_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosphatidylinositol-specific phospholipase C X" evidence="1">
        <location>
            <begin position="19"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5083212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="309" mass="36280" checksum="079A370EC8607FA7" modified="2022-05-25" version="1">MSNVKITKVHRKNILSLLPDNHLLGQLSLIGTHQSMTFSSSDIKLRKQELNITEQLNHGVRVFDISVRIETNYFKIYYQNQYLEASFNSLVYEINKFLKKNSQEFVILIINVDHEKKINSENILSPSYCEILNNYLGKYIGGERMHSKWSFDDKLHSLRGKILLATYQVTFAECAVWLGARCLMTDKLKFVENSFLYSHGNYQEDNIDYKWKKYMKFVASDLFDYYPCFIYDLSIYDEIHYSQGAAKYGGFDVNGQCFVPMNYRIDNYCRGDHKSAFNIFIVDYPTQEVIDHINGYNSDYHNPFEIALM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HAJ2</accession>
    <name>A0A8J2HAJ2_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Similar to ZNF84: Zinc finger protein 84 (Homo sapiens)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">HICCMSTLAB_LOCUS5165</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5089251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HAJ2"/>
    <dbReference type="OrthoDB" id="6077919at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048598">
        <property type="term" value="P:embryonic morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040029">
        <property type="term" value="P:epigenetic regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000100">
        <property type="entry name" value="Zinc finger 45-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001506">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000690">
        <property type="entry name" value="Zinc finger protein 354C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001498">
        <property type="entry name" value="Zinc finger protein 404"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000624">
        <property type="entry name" value="zinc finger protein 697"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000110">
        <property type="entry name" value="Zinc finger protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24394:SF29">
        <property type="entry name" value="MYONEURIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24394">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12874">
        <property type="entry name" value="zf-met"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="11" id="KW-0804">Transcription</keyword>
    <keyword evidence="9" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="8" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 13" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="113"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="140"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="168"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="196"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="224"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="252"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="280"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="308"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="76"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="79"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="95"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CAG5089251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="341" mass="40030" checksum="0B9E794A1E26A86F" modified="2022-05-25" version="1">MDENYPFEKVIIKVEIDEEEFQEDQSIFNYEDYNFGEDYPIDIEDIKIEVPDSHQDSLAELPIDIEEIKIEMPDFSPISKKKPRKRKAKVELKPKIRQKVSRRKPKAENERPYACSSCSSSFREKGSLNRHIKIHEAKTFICDICAAKFVQKGQLKVHMRIHTGEKPYGCTVCPEKFRSKMTLNQHMRIHTGEKPFQCDVCSRRFRQKVQMTVHMRIHTGEKPYTCSVCSAKFRERGTLSKHMLVHTGEKPYTCQLCLMKFRTKAHLKTHIFSHTGEKPYGCNICSSKFRRKCSLVQHLRTHEGEKLYTCSVCLTVFSKIATFTKHMLFFHTVDELLMFEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HAW9</accession>
    <name>A0A8J2HAW9_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS4423</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5087117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HAW9"/>
    <dbReference type="OrthoDB" id="6360372at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="73"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="114"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="154"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="241"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="176"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="186"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="205"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="245"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5087117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="299" mass="33317" checksum="4449D09B80C430AE" modified="2022-05-25" version="1">MHAVGLHSALAIKRQRNRRDEQRRARERRYSAQSGESGLTSPRASTGSLDRHHRHRHVIQQHHAGQGMVDSKVVTSIGMLHIGVVFLVLGGFLLGSGLLPGDLATWSSKGSGGWWNELVATGLFAVVVGIFLIVLNRVIAKREEDDLEEYVQRQLTRSRSGHRLERDVETGGLTTRHARKAKQLKKMTSLSSIELQSEKTTSSPPRSPPPAYSPPPVANGDHSVQPPLFLEQITEEEIISDRLETSTTNSLSPGSPSETRELLRNNSRHSKHNGTHTPQHNHNYHHHDEHPPIYVSARN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HBA2</accession>
    <name>A0A8J2HBA2_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS5785</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5090893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HBA2"/>
    <dbReference type="OrthoDB" id="7699715at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="DNA breaking-rejoining enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5090893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="489" mass="55384" checksum="EEAC5D4E2BF862E9" modified="2022-05-25" version="1">MGESSSEGSMDEEEVIRNFDTEAKIIVRSEATPKKSSDRYLLVYNTYKKWREDNKNSLSSSEENNLIVYFEELKLKLKPPTLWSIWSMLKKTLNVNDDVNIGNFLNLKSLIKSNAKGYKPRKAFVLRWNQIIQFMKEASDQTFLVMKVILIFGICGCLRCDEITNITVQDVEDLNDKYLVSINENKNDYGGQFIIGRVTIEPLDDNLDFNLNYADFDDDFSIDTIESGLTGVAENGFTTASNNPILIPNTKPNETNANKKCLFVDKPAIKLKFQQQSDIQPTYVQHANVQSPNEQQSNVQPLMKKCYSFVSWMQNPVDINLGSKAGPVGGWVKNEISEICVLRQSQTWCRVLKIKIVSPGIKKLKRFGLRPSGIYIMPRYNKWNSRPTSITIPWGLPPTPFQLGFSSTQLCSGIIATGGPQQVRFGSFQGVPITGIVLHLSTEESDNESLDVLCRVFSDLLLRESLMTQLSSGFIPLFRFSLPKISLFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HBS3</accession>
    <name>A0A8J2HBS3_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS478</name>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS6724</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001114">
        <property type="protein sequence ID" value="CAG5073535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5093283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HBS3"/>
    <dbReference type="OrthoDB" id="7612378at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5073535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5093283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="165" mass="19842" checksum="69F1CB0E3AD43B88" modified="2022-05-25" version="1">MEIILDMQEFRGPHNKFIMKEFASITIQNEINGVEEITPTLFQQPYHWKSQSKHYQRFNTWITRNHYGLSWDTGNIPYCDINKVINYTTHDKKYIYVKGVEKKLWLQAFIASDKNIIDLEDFEFPTLKDNNIYDYCSHHYNLNKNMFVYYSCALKKCEISKQNCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HBX1</accession>
    <name>A0A8J2HBX1_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Similar to ZC3H12C: Probable ribonuclease ZC3H12C (Homo sapiens)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HICCMSTLAB_LOCUS5145</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5089211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HBX1"/>
    <dbReference type="OrthoDB" id="392925at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036464">
        <property type="term" value="C:cytoplasmic ribonucleoprotein granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:RNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18719">
        <property type="entry name" value="PIN_Zc3h12a-N4BP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11980:FF:000001">
        <property type="entry name" value="ZC3H12A isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11980">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021869">
        <property type="entry name" value="RNase_Zc3h12_NYN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051101">
        <property type="entry name" value="ZC3H12/N4BP1_RNase_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12876:SF35">
        <property type="entry name" value="LD08718P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12876">
        <property type="entry name" value="N4BP1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11977">
        <property type="entry name" value="RNase_Zc3h12a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase NYN" evidence="3">
        <location>
            <begin position="322"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="37"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="114"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="284"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="186"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="40"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="76"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="124"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="284"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="304"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF11977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG5089211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="473" mass="54963" checksum="0B47E78B878F29DD" modified="2022-05-25" version="1">MKRRKLILRISNHRKSFKMNLLDESVIVCDTPKINKSSKKMNGSVQKNLSSPVRRQTRSQRKPLYPVHMSPVNRKNMCSSKTPQSVTKKKRLHEVEILSSRKRQKTCINETIVISDDDDNNNDNDNKNNDKSHESQMTHKLKDTPEVIVIDNFTPNVNNKRLRPRNSNVNNQEIKRKKKIEDKIKERKKLRKIQNMERTRNRARKNIEVSKKQNEDVAVIWSSAKDDNTALENNQKISTKSNYETPQLFFVDTKGDNSICEKMALPPQSEILYTANKFTKFDTAPTTSTATSTTTNTNNTVTSEQAKSNTSDDQNNKQIHKLREIIVDGLNVAFGYSLGRKIFEKNGLQLVLDYFQDRGHKVKIFLPQNQRNRYRGFLEQWYREGLVIFTPSRNIGGKKIVPYDDRFILDYATKCKGIVVSSDQYRDLWHEKPEWRETIEKRLLAPTFAGEYVMFPEDPLGRGGPSLNEFLKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HCJ8</accession>
    <name>A0A8J2HCJ8_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Similar to AIMP2: Probable aminoacyl tRNA synthase complex-interacting multifunctional protein 2 (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HICCMSTLAB_LOCUS5402</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5089853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HCJ8"/>
    <dbReference type="OrthoDB" id="424586at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017101">
        <property type="term" value="C:aminoacyl-tRNA synthetase multienzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042360">
        <property type="entry name" value="AIMP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041503">
        <property type="entry name" value="AIMP2_thioredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13438">
        <property type="entry name" value="AMINOACYL TRNA SYNTHASE COMPLEX-INTERACTING MULTIFUNCTIONAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13438:SF2">
        <property type="entry name" value="AMINOACYL TRNA SYNTHASE COMPLEX-INTERACTING MULTIFUNCTIONAL PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18569">
        <property type="entry name" value="Thioredoxin_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AIMP2 thioredoxin-like" evidence="7">
        <location>
            <begin position="111"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="61"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF18569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG5089853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="299" mass="33975" checksum="3F415EEEE1C1BF4B" modified="2022-05-25" version="1">MTIMYEMKAIINHNTVIERALCMYEMKNIHDDGDSSKHKCTIVSEVTDEFVNITKVPLAEVKALEVRQENILAQLAELKEQVLNLCNVLKNNTDTKAQQTKRTNRTPVTGNLVINVNPKKPCYSLIAVKKLWDDVDLRISPHHHCSIFSETPAGFEKSKPSEKDSVIDVSVIWRDVQDTQLIVSGFNSQIVLGETNILRYLVRLIDNESYEKTQSVAETLKIDKILDLAYELTHQNSPKDKQTTLNILDKLLGAHQWFSSKSLFNIADIAVWSAVKQSSLQKLPSNLTSWYKKCEGTFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HD66</accession>
    <name>A0A8J2HD66_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to Trub2: Mitochondrial mRNA pseudouridine synthase Trub2 (Mus musculus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS7707</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the pseudouridine synthase TruB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5095435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HD66"/>
    <dbReference type="OrthoDB" id="9995526at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009982">
        <property type="term" value="F:pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001522">
        <property type="term" value="P:pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2350.10">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002501">
        <property type="entry name" value="PsdUridine_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039048">
        <property type="entry name" value="Trub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13195">
        <property type="entry name" value="PSEUDOURIDINE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13195:SF0">
        <property type="entry name" value="PSEUDOURIDYLATE SYNTHASE TRUB2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01509">
        <property type="entry name" value="TruB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pseudouridine synthase II N-terminal" evidence="2">
        <location>
            <begin position="2"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5095435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="228" mass="26428" checksum="71248464F0931626" modified="2022-05-25" version="1">MKMHHVNYLSNEASGIQLWGVNKGALICHLMRQANSTRFYKVKGILGYATDNYFTTGKIVERSMFKQVKRHHIDMICASMQSSHQRKMFELCGLDIQSQAAYELAVQGPIRPADNKVPMLYSMKCVAFDPPDFTLEIVCINEDDMFLKTLVHNLGLMSRTNATCSQIQCYQYGIFTTNLGLLKRDWSIENIMKNLIIIRRILSKNKYLYCEDNQEAILREYFENKQTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HDF6</accession>
    <name>A0A8J2HDF6_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Odorant binding protein 3.0901</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HICCMSTLAB_LOCUS7857</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PBP/GOBP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5095736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HDF6"/>
    <dbReference type="OrthoDB" id="6610259at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005549">
        <property type="term" value="F:odorant binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007608">
        <property type="term" value="P:sensory perception of smell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd23992">
        <property type="entry name" value="PBP_GOBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.20:FF:000001">
        <property type="entry name" value="General odorant-binding protein lush"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.20">
        <property type="entry name" value="Pheromone/general odorant binding protein domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006170">
        <property type="entry name" value="PBP/GOBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036728">
        <property type="entry name" value="PBP_GOBP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21364">
        <property type="entry name" value="GENERAL ODORANT-BINDING PROTEIN 19A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21364:SF2">
        <property type="entry name" value="GENERAL ODORANT-BINDING PROTEIN 19A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01395">
        <property type="entry name" value="PBP_GOBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00708">
        <property type="entry name" value="PhBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47565">
        <property type="entry name" value="Insect pheromone/odorant-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035262317" evidence="4">
        <location>
            <begin position="25"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAG5095736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="146" mass="16558" checksum="53F137A62D482976" modified="2022-05-25" version="1">MRNIFISLIAILVIIEIHFFQVDARMTMTQIRNAMKPMGKTCVGKTGLSKEVQAGQHEGQFPEDEALMKYHECLLKLAKIADKSGKINLDTMLKQIDMMMPEDVISKAKAVTTECFNEIKSEEPARASFEFVSCYFLKGPEITFFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HDU2</accession>
    <name>A0A8J2HDU2_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Dynein light intermediate chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HICCMSTLAB_LOCUS7466</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Homodimer. The cytoplasmic dynein 1 complex consists of two catalytic heavy chains (HCs) and a number of non-catalytic subunits presented by intermediate chains (ICs).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Cytoplasm</location>
            <location evidence="1 11">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the dynein light intermediate chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5094952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HDU2"/>
    <dbReference type="OrthoDB" id="27603at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005868">
        <property type="term" value="C:cytoplasmic dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045504">
        <property type="term" value="F:dynein heavy chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008467">
        <property type="entry name" value="Dynein1_light_intermed_chain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022780">
        <property type="entry name" value="Dynein_light_int_chain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12688">
        <property type="entry name" value="DYNEIN LIGHT INTERMEDIATE CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12688:SF0">
        <property type="entry name" value="DYNEIN LIGHT INTERMEDIATE CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05783">
        <property type="entry name" value="DLIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10 11" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8 11" id="KW-0243">Dynein</keyword>
    <keyword evidence="5 11" id="KW-0493">Microtubule</keyword>
    <keyword evidence="9 11" id="KW-0505">Motor protein</keyword>
    <keyword evidence="6 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="189"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="375"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="436"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="384"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="443"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="473"/>
            <end position="496"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU366047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAG5094952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="505" mass="56020" checksum="A3081EBC09F9E6DC" modified="2022-05-25" version="1">MVTKNRIWAGKCMMAATAIMSQSNGLQLKKKEDINNKENLWSSILAEVQNSGNNKLPSNKNVLVLGDNESGKTTLIAKLQGVEDPKKGSGLEFAYIDVRDDYRDDQTRLSVWVLDGDPGHANLLKYALNAEKFPHTLVMLVAAMTTPWALLDQLQSWAALLGDHIDKLPLDNDTRQKCRQLNVKKWQDYTEPGDELDPGSPLRRTSRNLDDDADNLPLPEGVLTTNLGLDVVVVITKTDYMSTLEKEHDYKDEHFDFMQQWIRRFCLQYGAGLFYCSAKEDKNCDLLYKYLTHRIYNLPFRTPALVVEKDAVLIPAGWDNIKKIAILHENLQSMKPDDYYRDVIAQPSVNRKCVAREVEIVAEDEQAFLARQQATLSGLRDPSRSPTTRNQASTGPHIQVPSPNKKLDAKGASATPSGEGVLANFFNSLLYKKTGASPGGPGTNTPGSSGSSPIKIDGGPVDKAAMRNDAAAELDRITRDKTRDKKSLSSEHKSSSSDHNSSSEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HE09</accession>
    <name>A0A8J2HE09_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Similar to SOCS6: Suppressor of cytokine signaling 6 (Homo sapiens)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HICCMSTLAB_LOCUS5666</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5090524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HE09"/>
    <dbReference type="OrthoDB" id="6270897at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005942">
        <property type="term" value="C:phosphatidylinositol 3-kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046935">
        <property type="term" value="F:1-phosphatidylinositol-3-kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009968">
        <property type="term" value="P:negative regulation of signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.10">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000980">
        <property type="entry name" value="SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001496">
        <property type="entry name" value="SOCS_box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036036">
        <property type="entry name" value="SOCS_box-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10155:SF32">
        <property type="entry name" value="LP02169P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10155">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00017">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07525">
        <property type="entry name" value="SOCS_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00401">
        <property type="entry name" value="SH2DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00252">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00253">
        <property type="entry name" value="SOCS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00969">
        <property type="entry name" value="SOCS_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55550">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158235">
        <property type="entry name" value="SOCS box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50001">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50225">
        <property type="entry name" value="SOCS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0341">Growth regulation</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0727">SH2 domain</keyword>
    <keyword evidence="2" id="KW-0734">Signal transduction inhibitor</keyword>
    <keyword evidence="3" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="SH2" evidence="7">
        <location>
            <begin position="159"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="SOCS box" evidence="8">
        <location>
            <begin position="261"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="27"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAG5090524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="310" mass="35281" checksum="6DB261F8C19AB77B" modified="2022-05-25" version="1">MDEKKSISFLKSIKKKLSVKNFHKFRKKNTVKEPHESDAGTSGADLKEINAPSHEIFAGLKEDCLSINDSVDLKLSERISQSEDAVDFENQRNADHSKIETMCNSKESTHINTNTITTVHTHNNFSRGENNLDEPNVINEESSQSTLSLELLKLSKYGWYWGPMSGEQADAQLLSEPDGAFLIRDSSDDRHLLTLSFKSAGKLLHARIEHSGGMFSLCNQGESGRFSSIPALVDHSMSFSKYSVFCYSRPRHPGHPAFPVRLTKPVSRFTQIRSLQYLCRFVIRQNTRRDNIHKLPLPEAIKRYVEEDYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HE89</accession>
    <name>A0A8J2HE89_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Similar to styx-b: Serine/threonine/tyrosine-interacting protein B (Xenopus laevis)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HICCMSTLAB_LOCUS7996</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5096011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HE89"/>
    <dbReference type="OrthoDB" id="426001at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990444">
        <property type="term" value="F:F-box domain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008138">
        <property type="term" value="F:protein tyrosine/serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062026">
        <property type="term" value="P:negative regulation of SCF-dependent proteasomal ubiquitin-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070372">
        <property type="term" value="P:regulation of ERK1 and ERK2 cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14522">
        <property type="entry name" value="DSP_STYX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.10:FF:000036">
        <property type="entry name" value="Serine/threonine/tyrosine-interacting protein a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020405">
        <property type="entry name" value="Atypical_DUSP_subfamA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000340">
        <property type="entry name" value="Dual-sp_phosphatase_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052449">
        <property type="entry name" value="STYX-Interacting_Phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46588">
        <property type="entry name" value="SERINE/THREONINE/TYROSINE-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46588:SF1">
        <property type="entry name" value="SERINE_THREONINE_TYROSINE-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00782">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01909">
        <property type="entry name" value="ADSPHPHTASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00195">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50054">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035279752" evidence="3">
        <location>
            <begin position="19"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="4">
        <location>
            <begin position="60"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="5">
        <location>
            <begin position="125"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAG5096011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="240" mass="27463" checksum="BD93E838145F2E16" modified="2022-05-25" version="1">MNIFVLARFLIINITTMSCNIVSVDEKSVVESGFEDYFNIPEMMLAPNTTKEWSYTMRRSMQEVAPHLYLGPYSSASRSQLQPLKEIGITHIICVRQDIESQFIKPNFPGEFEYLVLNIADTVTENIIQHFRNVKDFINRALASGGRVLVHGNAGISRSAALVLGYVMEKYNCTPSQAYVLVQNRRFCINPNDGFMAQLREYEPIYKAQSMEIGHHNAISENRCKRTIHQIDERVETMDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HEQ7</accession>
    <name>A0A8J2HEQ7_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">CD109 antigen</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="21">TEP1-F</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="27" type="ORF">HICCMSTLAB_LOCUS8596</name>
    </gene>
    <organism evidence="27 28">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="27" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="17">Binds covalently through a thioester bond to the pathogen surface resulting in pathogen clearance.</text>
    </comment>
    <comment type="function">
        <text evidence="16">Modulates negatively TGFB1 signaling in keratinocytes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="19">Heterodimer of a TEP1-N chain and an TEP1-C chain non-covalently linked. Forms a complex composed of TEP1-N and TEP1-C heterodimer, LRIM1 and APL1C; the interaction stabilizes TEP1-N and TEP1-C heterodimer, prevents its binding to tissues while circulating in the hemolymph and protects the thioester bond from hydrolysis. Mature TEP1 and to a lesser extent full-length TEP1 interact with SPCLIP1; the interaction is induced by microbial infection.</text>
    </comment>
    <comment type="subunit">
        <text evidence="18">Heterodimer; disulfide-linked. Interacts with TGFB1 and TGFBR1. Forms a heteromeric complex with TGFBR1, TGFBR2 and TGFBR3 in a ligand-independent manner.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the protease inhibitor I39 (alpha-2-macroglobulin) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="27">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5097215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9998011at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004867">
        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002376">
        <property type="term" value="P:immune system process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02897">
        <property type="entry name" value="A2M_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.20:FF:000001">
        <property type="entry name" value="CD109 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1930:FF:000001">
        <property type="entry name" value="CD109 isoform 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000155">
        <property type="entry name" value="complement C3 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.130.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.1540">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1930">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2950">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.690">
        <property type="entry name" value="Alpha-macroglobulin, receptor-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009048">
        <property type="entry name" value="A-macroglobulin_rcpt-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036595">
        <property type="entry name" value="A-macroglobulin_rcpt-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050473">
        <property type="entry name" value="A2M/Complement_sys"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011625">
        <property type="entry name" value="A2M_N_BRD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041813">
        <property type="entry name" value="A2M_TED"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047565">
        <property type="entry name" value="Alpha-macroglob_thiol-ester_cl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011626">
        <property type="entry name" value="Alpha-macroglobulin_TED"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001599">
        <property type="entry name" value="Macroglobln_a2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019742">
        <property type="entry name" value="MacrogloblnA2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002890">
        <property type="entry name" value="MG2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041555">
        <property type="entry name" value="MG3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040839">
        <property type="entry name" value="MG4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008930">
        <property type="entry name" value="Terpenoid_cyclase/PrenylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11412:SF136">
        <property type="entry name" value="CD109 ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11412">
        <property type="entry name" value="MACROGLOBULIN / COMPLEMENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00207">
        <property type="entry name" value="A2M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07703">
        <property type="entry name" value="A2M_BRD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07677">
        <property type="entry name" value="A2M_recep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01835">
        <property type="entry name" value="MG2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17791">
        <property type="entry name" value="MG3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17789">
        <property type="entry name" value="MG4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07678">
        <property type="entry name" value="TED_complement"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01360">
        <property type="entry name" value="A2M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01359">
        <property type="entry name" value="A2M_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01361">
        <property type="entry name" value="A2M_recep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01419">
        <property type="entry name" value="Thiol-ester_cl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49410">
        <property type="entry name" value="Alpha-macroglobulin receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48239">
        <property type="entry name" value="Terpenoid cyclases/Protein prenyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00477">
        <property type="entry name" value="ALPHA_2_MACROGLOBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="13" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="9" id="KW-0391">Immunity</keyword>
    <keyword evidence="15" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="12 22" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0646">Protease inhibitor</keyword>
    <keyword evidence="28" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="10" id="KW-0722">Serine protease inhibitor</keyword>
    <keyword evidence="8 23" id="KW-0732">Signal</keyword>
    <keyword evidence="11" id="KW-0882">Thioester bond</keyword>
    <keyword evidence="22" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="22" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="23">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035286747" description="CD109 antigen" evidence="23">
        <location>
            <begin position="21"/>
            <end position="1484"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="1463"/>
            <end position="1481"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-2-macroglobulin bait region" evidence="24">
        <location>
            <begin position="445"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-2-macroglobulin" evidence="25">
        <location>
            <begin position="712"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-macroglobulin receptor-binding" evidence="26">
        <location>
            <begin position="1337"/>
            <end position="1426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00056820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00057615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00063008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00063781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00069665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00078071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="SMART" id="SM01359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="SMART" id="SM01360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="SMART" id="SM01361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="EMBL" id="CAG5097215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="1484" mass="166022" checksum="7E8544D739B9318B" modified="2022-05-25" version="1">MTMLTIVSLLLCSFVVATTAEPYYTVVAPKVVRPNSDYHVAVSTSGISTPVTISVELDGDLDNNEKFKVFHENVVEPYTTQVFKLETGDTSPGRYKLTARGTSGLLFSNTTSLQYIHKSFMVFIQTDRAIYKPGSEVLFRCVVLDSRLRPAPTRQLDVYITAIDGNGNRIKQWSRPPIIRGIFSGELTLSESPVLGDWKIVANVGDQTFEKEFQVAEYVLPKFEVAINAPKHATFKDGKIVATVSAKYTYGKPVKGEATITAYPDIFSGVLQPIFQAPIRKVVPIDGKVTVDFDIASELRLTDEYERPIELEVAVEEALTGRRQNVSMQMTLHKHKYTMELIKTSDYYKPGLKYTAFIKLSYHDGSPVRDNNNPVKISYGYTYNQSAYTNITRMLDNNGMIQLDFYPPNDSSENASPLNIEAEYLNLHEWFPATNQAMSPSNTFIQATVKTDKPSVNREIEIEVNSTVPLKYLNYEILGRGDILNAGSISVSDRHIASFRFLATYIMAPTAHVLVYYTREDGEIVADALDVELDNTLENFVNIKMSAEETQPGETVEVTMSAKPNSYIGVLGVDQRSLLLKSGNDISWEQVNKELKSYDMTEESPYSDMPFERSFWRPGSATADDVFNKMGTVVLTNGYIHENYPIRQPGYQESRVRGSAHGASTLRPDIGPPVTHRLVTRPPLAGPYAFSRIPTPVWNKPRVFLMHDISNTWLFTNSSSGYKGEAVIRRTVPDSITSWVLTAFSVDSTYGLGLIDAPRKLKVFKPFFISLDLPYSVMRGEIVAIPIVVFNYMDKDITADVVLEHAGQFEFAEVSNEVHDTPKLELFRKKRIEIKANSGSSVSFMIIPRDLGYITIKATATSKIAGDSVEHKLLVKAEGETQYRNKAVFLDLRDTRNIQMNLTVDIPKNFVPGSEFVEISAVGDILGPSIPNLANLIKMPFGCGEQNMLNLVPNIVILNYLKNTNQLTQAIQGKALRYLEVGYQQELTYRHKDGSFSAFGESDASGSTWLTAFVARSFKQAAEYIPVENRIINEALSWLAEVQAPSGSFPEVGHVSHRDMQGGASKGLALTAFTLIAFLENPVRKLKYNFDEGGKYRNTINKGVDYIVTNMEGLDDTYALSLCTYVLNLARHPYEDAAFNALESRASTKDDLKWWSKPIPVGDKNPWFDALPRSVDVEMTSYTLMTYLRKNLVTDSIAVMKWLVKQRNPEGGFSSTQDTVVGLLALSKLAEKLSTRSNNIAITIHYEGGGQSQMNINADNAMILQKHILPRKTRVVNITATGQGFAIIQVSTHYNLNVTGAWPLFTLDPQVDRISNENHLQLSICSGFVPTKESNESNMAVMEVSLPSGFTIDMDSLPSLQVSQHVKRVETKNGNTMVVLYFDKMVQKEYCPTISAYRTHKVAKQKPVPVSIYDYYDSSRRARVFYEPHVSTLCDICKDEDCENLCVGQPGNEKYNTPGSASQSFFCIYNYLVLFFGFLLLQNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HER5</accession>
    <name>A0A8J2HER5_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS8329</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5096676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HER5"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5096676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="129" mass="14732" checksum="33E3079DAD1FF272" modified="2022-05-25" version="1">MSIVLNHNHVHRLLYFAERKSEQPVAINLDSLYDAVEQEKEVAVKLNSTPKEATKTKKRKEKGDNNEAQKKKKKKKPSDQKSSNQQMENDSIIQFLDSPTHLRGTDSTSYGSTQGNLIFYLLLTIVELD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HF30</accession>
    <name>A0A8J2HF30_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 15">Guanylate cyclase</fullName>
            <ecNumber evidence="3 15">4.6.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">HICCMSTLAB_LOCUS8856</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 15">
            <text>GTP = 3',5'-cyclic GMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:13665"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:57746"/>
            <dbReference type="EC" id="4.6.1.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.2" evidence="3 15"/>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5097745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HF30"/>
    <dbReference type="OrthoDB" id="1890790at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004016">
        <property type="term" value="F:adenylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004383">
        <property type="term" value="F:guanylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001653">
        <property type="term" value="F:peptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007168">
        <property type="term" value="P:receptor guanylyl cyclase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07302">
        <property type="entry name" value="CHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06352">
        <property type="entry name" value="PBP1_NPR_GC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1230:FF:000004">
        <property type="entry name" value="Guanylate cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001054">
        <property type="entry name" value="A/G_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018297">
        <property type="entry name" value="A/G_cyclase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001828">
        <property type="entry name" value="ANF_lig-bd_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001170">
        <property type="entry name" value="ANPR/GUC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050401">
        <property type="entry name" value="Cyclic_nucleotide_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11920:SF274">
        <property type="entry name" value="GUANYLATE CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11920">
        <property type="entry name" value="GUANYLYL CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01094">
        <property type="entry name" value="ANF_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00211">
        <property type="entry name" value="Guanylate_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00255">
        <property type="entry name" value="NATPEPTIDER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00044">
        <property type="entry name" value="CYCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="Periplasmic binding protein-like I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00452">
        <property type="entry name" value="GUANYLATE_CYCLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50125">
        <property type="entry name" value="GUANYLATE_CYCLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13 15" id="KW-0141">cGMP biosynthesis</keyword>
    <keyword evidence="16" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="12 14" id="KW-0456">Lyase</keyword>
    <keyword evidence="9 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10 20" id="KW-0675">Receptor</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="469"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="18">
        <location>
            <begin position="538"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="domain" description="Guanylate cyclase" evidence="19">
        <location>
            <begin position="887"/>
            <end position="1017"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="16">
        <location>
            <begin position="824"/>
            <end position="855"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU003431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="CAG5097745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="1118" mass="125353" checksum="F8D4FE0F1066C24A" modified="2022-05-25" version="1">MRKKYRIIKLVLLFFTAFVFFSRSNYLSRITAKELFVRTYNVGVLMASHLDSPYPSCSGARAPGLAADMHFRDNVIAFIGPACAFALEPVARLAAYWNTPIITGMGDQPPSEGELSVTSGILGRLHKWKNESSGIFKDKSKYPTLTRMSYCQCRLRLVFSSIFKEFGWSHVALILDKSDLFSLTVGKNLEYGLRKDGLLKFVRELDGNAQDDSYHLYLRDASMYARVVILSVRGTLVRRFMLAAHALGMTRGDWTFLDVEIIQGSYWGDHDWEIGDVEDAAARKAYEALLRVSLLQPTSPRFQDFAEDVRIRAQTNYNYTFSDGEEVNFFIGAFYDGVYLLGMALNETLSEGGNILDGLAMTKRMWGRDFMGITGHVRIDEDGDRDADYSILDLDPITGRQLIFCLILFSIIKFEVVAHYLGLNREYNQVSGKKIHWPGGREGPPADIPECGFLGNDPACALKTDAYTLILYSSFALGVFLFAVSTAACFLYRHLRLSADLNNMSWRIRPEELLLEVSKTFSSKINLHQAMAEANNFGLEQKRRGSQLSGDSLAPTSMFTSVGIYKGERVAIKKVTKKKVVDVTKKLLWEIKQVRDVTSENTVRFIGACLCSPSPTVLILTEYCPKGSLKDVLNNDAIKLDWNFRMSLIHDIVKGMDYLHASEVNAHGKLRSCNCLIDGRFVLKISDFGLKTLTTPAELIIDDNYYTKLLWIAPELLPQTVLPGSAATQKGDVYSFAIILEEIILRGGPYEVAKSYMSSQEIVNRVSSGENPCFRPEVQPKDCPPDILCLMERCWSEISEDRPTFQAIRGIIRGIMKGYCENLMDDLLRRMEQYANNLEALVEEKTEQLTLEKRRSEELLYQVLPRQVAGQLMAGELVQPEQFESVTIYFSDIVGFTALCAQSTAMQVVDFLNDLYSTFDRIIGFYDVYKVETIGDAYMVVSGLPQRNGDEHAKEIGLMALAILDAVKSFKIGHRQDSQLSVRIGAHSGPVCAGVVGQKMPHYCLFGDTVNTASRMESSGLPLKIHVSETTKNILDKFGTFELELRGEVELKGKGTVTSFWLNGCTTPDPRLSSPKLRKHSTSPPDNGQCTTLNPLIFPQNILNAKNSNNTFINLSEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HFL2</accession>
    <name>A0A8J2HFL2_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Similar to Miga: Mitoguardin (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HICCMSTLAB_LOCUS7645</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitoguardin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5095310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HFL2"/>
    <dbReference type="OrthoDB" id="8880065at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008053">
        <property type="term" value="P:mitochondrial fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019392">
        <property type="entry name" value="Miga"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21508">
        <property type="entry name" value="MITOGUARDIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21508:SF5">
        <property type="entry name" value="MITOGUARDIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10265">
        <property type="entry name" value="Miga"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="104"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="7"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAG5095310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="415" mass="47300" checksum="0E5C4A4DFADA3F19" modified="2022-05-25" version="1" fragment="single">MELNSRGAGNSTSTSPRHLSTSLAPQGLEALEKALYCWEDALTAFSCTLGNNALALPSKADAAFTHDVQELLDLGYQMQSTAELLFIDQHSVLFCNEDEGSEASNRRASTARSYGREKDKAEAASSPESFASAKDGVADLREFEEFFEFFPHLEQQKLYHAALKEHEDKGIQCRRLHTELVKCGSDVEYVAKVHCLRQAYSRLFTLPGAATWIADIGRQVISDLIVYADRDPEEYLVHYENMLEFLGDPSNHKIMHEELSARGVKCINFYDIVIDFILLDSFDEVDKPPSSIKAILQNRWISASFRKTVSEYAVGTAVWSILASKRQMLKYNKGFLTHFYFISEQVSPVLVWGFLGPEGSLRSTCQYFRDQIVEFLVDIFNFFKVRYTNIDELAEDIWREMRIRVENINQRLALE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HFN0</accession>
    <name>A0A8J2HFN0_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Similar to RpL10: 60S ribosomal protein L10 (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HICCMSTLAB_LOCUS5295</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5089585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HFN0"/>
    <dbReference type="OrthoDB" id="10258869at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01433">
        <property type="entry name" value="Ribosomal_L16_L10e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.300:FF:000003">
        <property type="entry name" value="60S ribosomal protein L10, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1170.10">
        <property type="entry name" value="Ribosomal protein L10e/L16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047873">
        <property type="entry name" value="Ribosomal_uL16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018255">
        <property type="entry name" value="Ribosomal_uL16_CS_euk_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016180">
        <property type="entry name" value="Ribosomal_uL16_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001197">
        <property type="entry name" value="Ribosomal_uL16_euk_arch"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036920">
        <property type="entry name" value="Ribosomal_uL16_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003239">
        <property type="entry name" value="PRK04199.1-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11726">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00252">
        <property type="entry name" value="Ribosomal_L16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54686">
        <property type="entry name" value="Ribosomal protein L16p/L10e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01257">
        <property type="entry name" value="RIBOSOMAL_L10E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG5089585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="144" mass="16506" checksum="B1383B32B466F5F8" modified="2022-05-25" version="1">MVKNAGKDQFHIRMRLHPFHVIRINKMLSCAGADRLQTGMRGAFGKPQGTVARVNIGQPIMSVRSSDRHKASVIEALRRAKFKFPGRQKIYVSKKWGFTKYERAEYEELKNAGRLAPDGCNVKYLPEHGPLSEWKKFREILVPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HFS1</accession>
    <name>A0A8J2HFS1_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS5311</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5089633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HFS1"/>
    <dbReference type="OrthoDB" id="539213at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="31"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="128"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5089633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="237" mass="27000" checksum="24025BD2B35F09F7" modified="2022-05-25" version="1">MVKDLKTFKNDIDQVFFNLFQSNELIMMKNLNIWLIFILILTVAVIIIRIAEFLRKESKTVEQKNLSPEEIQVIKDGMIKGNVTLNHIKKLRALHVATERCYLKKNAKQCIEILTYCPHLVNVKQGPEGLTPFHRICNHGHSVLMTFMLSKGADPFLTTNSGENALCLAISWCIKHPTGGLACVEILQQHGCRLDNTNKWFRIYLHAASLAGHKNLVRWMFSQAAPLAFRSSSFPLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HFS5</accession>
    <name>A0A8J2HFS5_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Soluble interferon alpha/beta receptor OPG204</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">HICCMSTLAB_LOCUS7308</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Counteracts the antiviral effects of host IFN-alpha/beta and key IFN-inducible proteins involved in viral RNA degradation suxh as host OAS1. Acts as a soluble IFN-alpha receptor and thus inhibits the interaction between host IFN-alpha and its receptor.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Interacts with host IFNA1.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5093982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HFS5"/>
    <dbReference type="OrthoDB" id="10253878at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0039502">
        <property type="term" value="P:symbiont-mediated suppression of host type I interferon-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015621">
        <property type="entry name" value="IL-1_rcpt_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11890">
        <property type="entry name" value="INTERLEUKIN-1 RECEPTOR FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11890:SF44">
        <property type="entry name" value="X-LINKED INTERLEUKIN-1 RECEPTOR ACCESSORY PROTEIN-LIKE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1" id="KW-0244">Early protein</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2" id="KW-0945">Host-virus interaction</keyword>
    <keyword evidence="7" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="2" id="KW-1090">Inhibition of host innate immune response by virus</keyword>
    <keyword evidence="3" id="KW-1114">Inhibition of host interferon signaling pathway by virus</keyword>
    <keyword evidence="6" id="KW-0922">Interferon antiviral system evasion</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0732">Signal</keyword>
    <keyword evidence="12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0899">Viral immunoevasion</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035234367" description="Soluble interferon alpha/beta receptor OPG204" evidence="13">
        <location>
            <begin position="25"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="664"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="14">
        <location>
            <begin position="292"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="14">
        <location>
            <begin position="557"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="28"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="28"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00041012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00045444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CAG5093982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="754" mass="83794" checksum="1BB5B4D1C3127B92" modified="2022-05-25" version="1">MEMLFKNFFIVLIIINIHLTYGRASEASTNASLPGSTTPSVVTLDTEGPEFSPDSQFDANNYEDNNSASSVVFVDVPQHTETALGTSVLLACRTAHPVVDCQWSWQPLPPVNLPLPDINPSNSNETTREILQVSTEAVFSPPTTANTQSLPVKQFPAFGNNSNDCSVRFTNYKYEQVGYWTCAARTTVNTSFVKESITFLESDDAIEAAPLSPFEIPCRTLGPVSECQWSWRLANQTELWNIEVKKFPSFGENNTDCTIKIPSALPEHEGLWTCGVLSDSAQNSSSFVVNRPIKLLLSEVEFIQLSRGIQTALGESALLRCQVNKPVVQCEWSWKPLNSSKEPMVIKNFVPNDDNKHDCSVRFKNVLEEEEGLWTCAVRLTPHGRLHEAAPAKLTLLPSAKINFTEAPENMSVAVSSHQLLKCVANTRVEKCTWLWKSLNDDGEVVAKDSFPSYGSLGTNCSLNINAIRMEDQGSVYLRCVTSSQVEQCRWSLTPVNSNTTVVVKQFKPVVPAGRDCSVRLSHALAEQEGLWTCGVKVHGTETYMNAPPAKLSLLEPAPVRVAITTNTHEIVTLGCKLYPLPSDTTCQWAHDLKDKKRTNATHKLRQGVLMNHTSGICTIQFKPDVNDLGLWTCKFIIKTDKGNFVLGNSSLTLVIKYTEDQRLGWIVGAATTFVLFLMILAVVLIVWRARLFTMESTRIFETAPLREKNQEDRKDSVDLELSDTRLSVHSSSNSVLSRNSTFLGHADKYQHPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HFV3</accession>
    <name>A0A8J2HFV3_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Homeobox domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HICCMSTLAB_LOCUS6862</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 2 3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5093472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HFV3"/>
    <dbReference type="OrthoDB" id="6159439at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050649">
        <property type="entry name" value="Paired_Homeobox_TFs"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24329:SF543">
        <property type="entry name" value="FI01017P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24329">
        <property type="entry name" value="HOMEOBOX PROTEIN ARISTALESS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 3" id="KW-0371">Homeobox</keyword>
    <keyword evidence="2 3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="5">
        <location>
            <begin position="11"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="2">
        <location>
            <begin position="13"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="153"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="287"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="157"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="292"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAG5093472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="321" mass="36077" checksum="C0B8EBB56608FAD9" modified="2022-05-25" version="1" fragment="single">MPSIQCDGVAVAVWFQNRRAKWRKKEKTMGRDPSYMHVGQDMNDLPLAPPLMHNPSTPTAGFPWYMPSVFSPWMSPANTSKIPAPLQAALLSQYMGLSSLNSLLPVGFNSTGVLGHSQLQHQPQQQPQHQRDQLNSQLQQIHPLLLDVQNIPQNLSSKHDRDDDSTSSEDEIRRQNMTDLSLDPPVVHNPSTPSTGFPWYMPSVFSPWMSPANTSKIPVPLQAALLSQYMGLSSLNSLLLVGFNLTSVLSHLQLQPQPQQLPQHQRDQLNSKLQQIHPLLLDVQNIPQNLSSKHDRDDDSTSSEDEIRRQSAEVFRVKAEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HG79</accession>
    <name>A0A8J2HG79_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Similar to Hdgf: Hepatoma-derived growth factor (Mus musculus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HICCMSTLAB_LOCUS8066</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HDGF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5096151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HG79"/>
    <dbReference type="OrthoDB" id="62853at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd05834">
        <property type="entry name" value="PWWP_HRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.10">
        <property type="entry name" value="Conserved domain common to transcription factors TFIIS, elongin A, CRSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036218">
        <property type="entry name" value="HIVI-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021567">
        <property type="entry name" value="LEDGF_IBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000313">
        <property type="entry name" value="PWWP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035441">
        <property type="entry name" value="TFIIS/LEDGF_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12550">
        <property type="entry name" value="HEPATOMA-DERIVED GROWTH FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12550:SF70">
        <property type="entry name" value="JIL-1 ANCHORING AND STABILIZING PROTEIN, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11467">
        <property type="entry name" value="LEDGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00855">
        <property type="entry name" value="PWWP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00293">
        <property type="entry name" value="PWWP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140576">
        <property type="entry name" value="HIV integrase-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63748">
        <property type="entry name" value="Tudor/PWWP/MBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50812">
        <property type="entry name" value="PWWP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PWWP" evidence="7">
        <location>
            <begin position="10"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="104"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="157"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="372"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="75"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG5096151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="391" mass="44447" checksum="AB5164D8D164E69F" modified="2022-05-25" version="1">MVKLVKKFVVGDKVFAKVRGYPPWPAKIRKVPESNKKNGKYEVYFYGTGEKGECTLDRIYDYHENKDKYGKPSKAKKFLEGMQELEQDIEKVEDKTPTITETKEAVADESDHENNQTTTEPSAGVQLDSDVESTLVIDESDKKKSLKRKTILNTSNSTVNTIGRGRPKVKHEEPNENVSTQSNAKKRMSVEKDDKKLIINENLNQNEKTKRLRTESQLIELNNQIKSYLSLEQADTDKCLRAMDDVLGLTIDSLMLKKHSNVVETVKRLRRYIGNLSEWSLSEEAVKNFKQKAQQIREKADEMYNKFKTLFIIPDGQSFWQTFSEQVTQFKEVTKNMSEPTIFGLLVDPTNPESTNANDVLVLSGDEGVTQNDVVAKGDLSNDETSSPTSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HH66</accession>
    <name>A0A8J2HH66_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Similar to AAEL007634: Protein KRTCAP2 homolog (Aedes aegypti)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HICCMSTLAB_LOCUS10203</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the KRTCAP2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5101130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HH66"/>
    <dbReference type="OrthoDB" id="1111004at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018614">
        <property type="entry name" value="KRTCAP2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32001">
        <property type="entry name" value="KERATINOCYTE-ASSOCIATED PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32001:SF1">
        <property type="entry name" value="KERATINOCYTE-ASSOCIATED PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09775">
        <property type="entry name" value="Keratin_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="35"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="75"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAG5101130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="160" mass="17764" checksum="1946D0CA7D5C579A" modified="2022-05-25" version="1">MAVTSGVSFILSSIFTVILFSGMQMYKSWLTSSQLHTIFGGYLGSMLFIFILTAVGNLESSIFGKNFQLKLFPEVFISLLFSMTASGLVHRVSTTTCFLFSMVALYYINKISQENYSAPITTTTLHTKKKNFVLVAEIFKGFVIGMRTNGVLGTNFSVLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HIA4</accession>
    <name>A0A8J2HIA4_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Mitochondrial fission process protein 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Mitochondrial 18 kDa protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HICCMSTLAB_LOCUS10882</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MTFP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5102172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HIA4"/>
    <dbReference type="OrthoDB" id="424969at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000266">
        <property type="term" value="P:mitochondrial fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019560">
        <property type="entry name" value="Mitochondrial_18_kDa_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11001">
        <property type="entry name" value="MITOCHONDRIAL FISSION PROCESS PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11001:SF2">
        <property type="entry name" value="MITOCHONDRIAL FISSION PROCESS PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10558">
        <property type="entry name" value="MTP18"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="83"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="120"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00029631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAG5102172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="165" mass="18684" checksum="9490081352D96584" modified="2022-05-25" version="1">MKVEDDSTEVDIFRDTSLRYLGYTNEVGEAFRSIVPKSIVWISYVIASGYVVADTAHKGIKEYGKNGAENKNKRIFLSASDTLIWQSFASVIIPGLVINRICAGVRFMQRNAKSPIMRNPWMSTIVGLISIPLIIHPIDDGVERTMDSTYRQWTGYHPLKEIENK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HID3</accession>
    <name>A0A8J2HID3_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Similar to Vps41: Vacuolar protein sorting-associated protein 41 homolog (Mus musculus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HICCMSTLAB_LOCUS6022</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Lysosome</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5092296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HID3"/>
    <dbReference type="OrthoDB" id="244107at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030897">
        <property type="term" value="C:HOPS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009267">
        <property type="term" value="P:cellular response to starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034058">
        <property type="term" value="P:endosomal vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016236">
        <property type="term" value="P:macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057780">
        <property type="entry name" value="Beta-prop_Vps41"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000547">
        <property type="entry name" value="Clathrin_H-chain/VPS_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045111">
        <property type="entry name" value="Vps41/Vps8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12616">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING VPS41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12616:SF1">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 41 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23411">
        <property type="entry name" value="Beta-prop_Vps41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23556">
        <property type="entry name" value="TPR_Vps41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23413">
        <property type="entry name" value="zf_RING_Vps8_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00299">
        <property type="entry name" value="CLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50236">
        <property type="entry name" value="CHCR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0458">Lysosome</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="repeat" description="CHCR" evidence="8">
        <location>
            <begin position="527"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="9">
        <location>
            <begin position="763"/>
            <end position="805"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAG5092296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="813" mass="93553" checksum="1F461AAC2841D0BA" modified="2022-05-25" version="1">MQNDIKNILQNDAASCIAVHPKFLCLGSHMGKIHLLDHQGNNIQSKTLQAHSLTVNQISIDQNGDYIASCCDKGKIFIYGLYTRENNNIINLERQIKSIALDPAFSKSGTSKRFITGDDKLMLYEKTFLSRLKLTVLSEAEGGVRSVAWAGQFVAWASDTGVRLYDLNARCSLGLMKWPRTPEAPPENYRCNLRWNGDRTLLIGWVDTVRICQIRKRSHQEMVNRNLPEFAVDPISTFQVDFYISGIAPLENQLVLLGCLKELSDKGTSQRPTLHVVEPKYQDFVDVSANFLGLRGYEAYNCNDYHLDCLPDENRFFIVSPKDIVVASLYDADDRIEWLLSHKKFEQALEAVTVNSGRDCKRHTLIYVGRVYLDHLLACGKYDEAGKLCLKVLGRDKKLWEEEVYKFARVHQLRSISSYLPRGDVTLDPLVYEMVLYEYLKMDPDGFLQLVKEWPAKLYTVAAVVNGVLEHLLVHNTRQNVLLEALAILYSHDGKYDKALAMYLKLRHKDVFQLIQKHQLYNAVYDMIEGLMDLDADRAIQFFLEKDRVPSEVVVAKLQNNPRYLYLYLDALDKRDTKDSKGKYHGLLIRLYADYSRDKLLPLLRRSDNYPIQSALDICSQRQFYPEMVYLLGRIGNTSEALGLMTRELNDMESAIAFCQEHDDEELWNDLINYSLSNPENITFLLQKIGTYVDPRLMVQRIAPGMEIPGLKKALVKMMCDYRLQVSVQEGCKKILSNDYFNLHERLVKAHQKGLFVDDDQMCGACHRKVIVRDPRNLVVFYCKHLFHEDCLPDFEQIENCVICNPQKDKVIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HIE5</accession>
    <name>A0A8J2HIE5_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Protein-serine/threonine kinase</fullName>
            <ecNumber evidence="10">2.7.11.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HICCMSTLAB_LOCUS8234</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[pyruvate dehydrogenase E1 alpha subunit] + ATP = O-phospho-L-seryl-[pyruvate dehydrogenase E1 alpha subunit] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23052"/>
            <dbReference type="Rhea" id="RHEA-COMP:13689"/>
            <dbReference type="Rhea" id="RHEA-COMP:13690"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the PDK/BCKDK protein kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.-" evidence="10"/>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5096487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HIE5"/>
    <dbReference type="OrthoDB" id="241648at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004740">
        <property type="term" value="F:pyruvate dehydrogenase (acetyl-transferring) kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010906">
        <property type="term" value="P:regulation of glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16929">
        <property type="entry name" value="HATPase_PDK-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.565.10:FF:000007">
        <property type="entry name" value="Mitochondrial pyruvate dehydrogenase kinase isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.20">
        <property type="entry name" value="Alpha-ketoacid/pyruvate dehydrogenase kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036784">
        <property type="entry name" value="AK/P_DHK_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018955">
        <property type="entry name" value="BCDHK/PDK_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039028">
        <property type="entry name" value="BCKD/PDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11947:SF3">
        <property type="entry name" value="[PYRUVATE DEHYDROGENASE (ACETYL-TRANSFERRING)] KINASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11947">
        <property type="entry name" value="PYRUVATE DEHYDROGENASE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10436">
        <property type="entry name" value="BCDHK_Adom3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69012">
        <property type="entry name" value="alpha-ketoacid dehydrogenase kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="8 10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Histidine kinase" evidence="11">
        <location>
            <begin position="234"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU366032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAG5096487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="417" mass="47640" checksum="3B3833BFC45C91DD" modified="2022-05-25" version="1">MRLTRRCLGNITKMLDFYSQFNPSPLSIKQFIDFGLSACERKSFIFLRKELPVRLANIMKEIHLLPEHLLRMPSLGIVNNLYVTSFEEIIHFEKAEVNETTLDKFCQALIKIRNRHSDTVEVMAKGILELKESHDVDAQMENNIQYFLDRFFMSRVSIRMLINQHTLLFGGVLNGDNRHVGCIDPSCDVVSVIRDAYENARFLCDQYYLASPELIIKQHNDFENGNQIRIVYVPSHLYHMLFELFKNSMRAIMEYYDGRSDSYPSIEVNIVRGKEDICVKMSDRGGGIPRSQMDQLFKYMYSTAPQPSKSDAHTVPLAGYGYGLPLSRLYARYFHGDLIVLSCEGYGTDAVIYLKALSNEANELLPVFNKTSSKFYRTPVPTADWSSSCGGGMAGRQLNVSHNNGHRLPNGLSITTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HII3</accession>
    <name>A0A8J2HII3_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Similar to HM13: Minor histocompatibility antigen H13 (Homo sapiens)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HICCMSTLAB_LOCUS8294</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase A22B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5096607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HII3"/>
    <dbReference type="OrthoDB" id="29661at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098554">
        <property type="term" value="C:cytoplasmic side of endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098553">
        <property type="term" value="C:lumenal side of endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042500">
        <property type="term" value="F:aspartic endopeptidase activity, intramembrane cleaving"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033619">
        <property type="term" value="P:membrane protein proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007369">
        <property type="entry name" value="Peptidase_A22B_SPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006639">
        <property type="entry name" value="Preselin/SPP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12174:SF23">
        <property type="entry name" value="MINOR HISTOCOMPATIBILITY ANTIGEN H13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12174">
        <property type="entry name" value="SIGNAL PEPTIDE PEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04258">
        <property type="entry name" value="Peptidase_A22B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00730">
        <property type="entry name" value="PSN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="83"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="115"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="165"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="190"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="212"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="265"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="296"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="325"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAG5096607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="404" mass="45169" checksum="A3E32DBCAF1A1FE0" modified="2022-05-25" version="1">MDGVIDKVLAQSNESLAENENSTSTRIPSTPEGMALAYCSLIIMAILPIFFGSYRSVKHHKEQKKAFEAGGEKPETMSQKDAAMFPLISSVALFGLYIFFQIFSKEYINLLLTGYFFFLGILALCHLTSPIISSLVPAAIPKTQYHIHFTEGEGDKVESIIDYKFNLHDIVCLICCSMIGAWYLFQKHWIANNLFGIAFAINAVELLHLNNIVTGCILLGGLFVYDIFWVFGTNVMVTVAKSFEAPIKLVFPQDMLEQGFSAKNFAMLGLGDIVVPGIFIALLLRFDHSLSRRSNTYFYSTFFAYFMGLLTTMLIMHLFNHAQPALLYLVPACLGTPLLVALIKGDIKTLFLYEDHPSNPTNDEKIVTPLIENSTQLDKSKRKGKVIAKTAEDNDSQVCMKKDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HJ97</accession>
    <name>A0A8J2HJ97_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Similar to RAB11FIP1: Rab11 family-interacting protein 1 (Homo sapiens)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HICCMSTLAB_LOCUS9980</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Recycling endosome</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5100907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HJ97"/>
    <dbReference type="OrthoDB" id="8956628at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055037">
        <property type="term" value="C:recycling endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045055">
        <property type="term" value="P:regulated exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000151">
        <property type="entry name" value="Rab11 family-interacting protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.2440">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037245">
        <property type="entry name" value="FIP-RBD_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037789">
        <property type="entry name" value="FIP_classI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019018">
        <property type="entry name" value="Rab-bd_FIP-RBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15746:SF23">
        <property type="entry name" value="RAB11 INTERACTING PROTEIN, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15746">
        <property type="entry name" value="RAB11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09457">
        <property type="entry name" value="RBD-FIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144270">
        <property type="entry name" value="Eferin C-derminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51511">
        <property type="entry name" value="FIP_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0967">Endosome</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="C2" evidence="8">
        <location>
            <begin position="1"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="FIP-RBD" evidence="9">
        <location>
            <begin position="545"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="190"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="256"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="381"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="568"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="196"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="256"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="304"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="381"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="419"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="446"/>
            <end position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAG5100907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="615" mass="69422" checksum="39B6AC919FAA1445" modified="2022-05-25" version="1">MDPVKPCKIPVNQVQRARGLLTKGKHKTNDCFVTIGLGKEKYQTSVKEKASENVEWHEECELQIPSQGNTAEIVLTALHRNFLGVDEFLGMVTVPLSSFDVYERPRNRWYSLGSKPGKENTKERGELEVKIGFIVKAGSLTDLTRKERHKSSLGQLSTAAHSIGGSLLSIGSLEKRKGLKKLAKSIGNRVKGKSKNKLDHEHEFDEVEEHQIRPTRQEPGEADPGVISEDDDEFTVRIKSYVNFIFQFDDLSHKSSASSLNAPVSSGLTSGYSSNSTTQSSRTTDLNILSTPTNPAPNKPPRFSTGSNLNSSLSSNNLTGNNNNINNNNNNNINNNNNEAEQDEWGRKLYGLQSSNISNKKWDNKLTPKIVIDQAKDNRELTTSSVNLSPSTATTTMRFRDTPEPPSPAPREIIQVKRTNKDDKISMKDRNSKEEKQLISGSIGGGRDRSPNVKDDKAGNKSQKDDKISKKDKKNREKELLKGKDINEEVKLSSERIIIGGEDATKNNMGVKSRLPHEVLAQFDGKTREVIIHNYHYHHHHHRHYHCRELFQIYINLCFIFQDLIEMALQLQTEVNDKKRRLADLEDYIDSLLLRVIETSPRILQNPYSNNRRLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HJL7</accession>
    <name>A0A8J2HJL7_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS11665</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5103749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="7667137at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039999">
        <property type="entry name" value="LYAR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13100:SF10">
        <property type="entry name" value="CELL GROWTH-REGULATING NUCLEOLAR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13100">
        <property type="entry name" value="CELL GROWTH-REGULATING NUCLEOLAR PROTEIN LYAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035286745" evidence="2">
        <location>
            <begin position="24"/>
            <end position="1332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="134"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="250"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="476"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="718"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="927"/>
            <end position="984"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1138"/>
            <end position="1178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="152"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="214"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="256"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="484"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="540"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="553"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="566"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="718"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="735"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="935"/>
            <end position="963"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5103749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="1332" mass="147382" checksum="8EB6735F41E1445F" modified="2022-05-25" version="1">MKIFAAAILILCVVIDQKATVQGGLFDIFRGKDKTPDEASGEGSGGFSGGLSGNIKLPGNILSECSVGGNVNGNIGASTSGGIQGGVNAGVNLPSCDCIRKFDTQGSVGGGGSAGFGGFRVSGGANFGGSLAMPGVNCVETDNPPEEKPNEEQDPSEEQESSEDENSPEEESSKEEEEEEESSEEEEEEEEEEEEEEEEVDVTTLPLCADLRQQDLQGSLGGTDTSNKVAPGNRNKDNVFEKISVIIPGVNCYEPEPPEEEFEESTEAPEKSEEYEESTEAPEESEESEESTEAPEESEESEESTEAPEKAPGTNSYCYRIDIDRDVILSPTNNFLTVSPVGNVDAPAEFYQTMNMSNALQFYSATINLEKKLIYESKPEKKMTNACDDSYPEGSIEANIWKIINLEVMAGEGCPVEKGSGYTFPQWLRGTELMFDEPLDYGNYSLETDFDTPQGAWALTLIFYFVVDENSVCTGGENFKESTEAPEESEESEESTEAPEVSEESEESTEAPEESEESEESTEAPEVSEESEESTKAPEESEESEESTEAPEESEKSEESTKAPEELEESEEESEQCYVVDMDVQVVKIPIFMDVLNKPMDKDNAFKINGVGMKVDGEFIYESISEEMTNACEDSYPEGSFQANIWHMFNLGILKGQGCPVEGGRIDTFPKKLDDVQLKINKRLEPGDYTANLDLAAPDGTWAGAIYFYFKLDGPSDCREEEKPQEPMEPVKDDGLEESEESTEAPEESEESEELTEAPEKAPGTNSYCYRIDIDRDVIFSPTNNFLTVSPVGNVDAPAEFYQTMNMSNALQFYSATINLEKKLIYESKPEKKMTNACDDSYPEGSIEANIWKIINLEVMAGEGCPVEKGSGYTFPQWLRGIEVTFNEPLDYGNYSLETDFDTPQGAWALKLIFYFVVDENSVCTGEENFNESTEAPEESEESEESTEAPEESEESEESTEAPEESKESEESTEAPEEAPGTNSYCYRVDIDRDVIMSPTNNFLTVSPVGNADAPAEFYQTMNMSNALQFYSATINLEKKLIYESKPEKKMTNACDDSYPEGSIEANIWKIINLEVMAGEGCPVEKGSGYTFPQWLRGTELMFDEPLEYGNYTLLVDFDTPQGAWALKLEFEFVVDENSECTESESSDESTEALEELEESEESTEAPEESEESEEESEQCYIIDMDVQVVKIPIFMGVLNKPMDKDNAFKINGADMKVDGGFIYESISEEMTNACEDSYPEGSFQANIWHMFNLGILKGQGCPVEGGSIKTFPKKLDDVQIKINRRLEPGDYTAHLDLAAPDGTWAGAIYFYFKLDSPSECREEEEPQEPIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HKF0</accession>
    <name>A0A8J2HKF0_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS9219</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5099757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HKF0"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5099757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="268" mass="29978" checksum="2FF7E7C2DDE7DEAD" modified="2022-05-25" version="1" fragment="single">MELGAWCLVLGVVRRNIKKKINIAPLVPVQSSATTEKSTGQKYSSPPGSHATGFVQPSPGINLCLPRPHTSRVQSSLTGVRSLVISSGGVCKREPIENQKKKKKKKKKKKKKKKKPNQWRVTGMACGVTALGFQQTRKECPLRLQLDAIVVISTFGISREQKPALPCLALLRRIRIKMSFFNVVPTDQAGMVQNKSPIFSSVSTHPFPRPISLSFSFLFIESHEDPLKFHETSHVLPKTFKDPPERLLLNYKSSLDNIIQCCVLRKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HKG9</accession>
    <name>A0A8J2HKG9_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein arginine methyltransferase NDUFAF7</fullName>
            <ecNumber evidence="7">2.1.1.320</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HICCMSTLAB_LOCUS9932</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Arginine methyltransferase involved in the assembly or stability of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>L-arginyl-[protein] + 2 S-adenosyl-L-methionine = N(omega),N(omega)'-dimethyl-L-arginyl-[protein] + 2 S-adenosyl-L-homocysteine + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:48108"/>
            <dbReference type="Rhea" id="RHEA-COMP:10532"/>
            <dbReference type="Rhea" id="RHEA-COMP:11992"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29965"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:88221"/>
            <dbReference type="EC" id="2.1.1.320"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the NDUFAF7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.320" evidence="7"/>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5100859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HKG9"/>
    <dbReference type="OrthoDB" id="438553at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035243">
        <property type="term" value="F:protein-arginine omega-N symmetric methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032981">
        <property type="term" value="P:mitochondrial respiratory chain complex I assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12710">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003788">
        <property type="entry name" value="NDUFAF7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038375">
        <property type="entry name" value="NDUFAF7_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12049">
        <property type="entry name" value="PROTEIN ARGININE METHYLTRANSFERASE NDUFAF7, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12049:SF7">
        <property type="entry name" value="PROTEIN ARGININE METHYLTRANSFERASE NDUFAF7, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02636">
        <property type="entry name" value="Methyltransf_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5 7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU364114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG5100859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="411" mass="46845" checksum="7A22B8B3DFBB2CEA" modified="2022-05-25" version="1">MRHLVNIRRAKLFLSTYEKLVNRSSATLMRRYSSNASKESSRDKKPSLHKHLHAKIKSCGPIPVAEYMKEALTNPTAGYYMLRDVFGAEGDFITSPEISQLFGEMLGIWVLNEWRKISKENFQLVELGPGRGTLSKDILKVFKQLKALNKLSLHLVEVSPALSEIQATKLCTSSKEVTPILISNSDDRNEKHYREGVTDDGTHVFWYRSIEHVPKKFSVFIAHEFFDALPIHKFQEDEKRDHVEASPQMMVIIDYMATFLKECGGFAFIADYGHTGDKTDTFRAFKKHQQQDPLVDPGTADLTADVDFAMIKKIATKDDRMIAFGPVSQKKFLLDLGIDVRLNMLLHKTTDADRKDLISGYKMLVDEDKMGKCFKIMSLFPSILKDHLMTWPVIGFIDSKTNEKLSGDKDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HKT7</accession>
    <name>A0A8J2HKT7_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Similar to sub: Kinesin-like protein subito (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">HICCMSTLAB_LOCUS10187</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Spindle</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5101114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="123929at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072686">
        <property type="term" value="C:mitotic spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005876">
        <property type="term" value="C:spindle microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008574">
        <property type="term" value="F:plus-end-directed microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090307">
        <property type="term" value="P:mitotic spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051231">
        <property type="term" value="P:spindle elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047149">
        <property type="entry name" value="KIF11-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47970:SF29">
        <property type="entry name" value="KINESIN FAMILY MEMBER 20B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47970">
        <property type="entry name" value="KINESIN-LIKE PROTEIN KIF11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57997">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4" id="KW-0493">Microtubule</keyword>
    <keyword evidence="8 10" id="KW-0505">Motor protein</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="13">
        <location>
            <begin position="75"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="629"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="939"/>
            <end position="958"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1376"/>
            <end position="1473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1486"/>
            <end position="1510"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="651"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="723"/>
            <end position="898"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="635"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="943"/>
            <end position="958"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="1399"/>
            <end position="1412"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="171"/>
            <end position="178"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CAG5101114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="1510" mass="174388" checksum="F1036C130D964CFD" modified="2022-05-25" version="1">MSGTNEHESKLDETLDPIRPLSIGTGEMSYIYGRDPSILSYGQRPGPSVETKKNLYSVYEVEETVASLDVSSAQTIKVYLRLKPFNKNVKLTAQEEDAYRITSSSTLLTKLPSQDSHSSIRSSSADLVCRKYIFTETFGPEVSQGQFFERVLQPQMPDFLTGQNATIMTYGTTNSGKSFTLQGTAMEPGLIPRSLEHIFANINPKEAPHFKPLNHSEVVKLSSSEKILEIENKTKLLTYGSTDRNQYINAFKKMQQVLEKEVPEFRARESTDAHCAVWVSFAEIYNETIYDLLSNDTSKRRPILKLATDNQGATYIKGLKSVFVNSSCEAYQVLMAGQYNLKVAATALNARSSRSHCIFTIRLLRYFSENDIKSVEMSTFTFCDLAGSERLKKTLNIGDRLKEAQNINTSLMVLGRCLKSIYEVQTVKQQRSEVIGPFRESKLTRLFQTALSGKEPIALIVNVNPSPNLYVETQNVLNFAAIAKKIIIQPKLKKTRRSKTRFSHLVLQTKNTITDWDEPPTECDLESIDDQSSVEDMGYVPAEDYEQVLEENEKLRKEIAQIKSAAFKKDLATREEISKYYMTTIKKMEEDHQARLRNIEAEHQTLHEWELDKVETFYQNKLQAVKSYKRKRSEDYDDEDDDDDDDMDTSKGELEIQVRQLNSKVDELKDKLKQALKEKDEILVQKNSATYELSLAKEELKTTMNVVVALENSHVNGKNEAYIEELKQQLSDCEKKKKLHEYTLNEAKKDFIEMRNEIDSKNSQINKLEIELAHKDEELCDLRQEFHNTEDTLSQKEIILREYEEIIDSQSQKLLKLKEEHENLKQLYKESSKETVLEIQERNSDANEIIGDLEDKLEAAENEIVLLKEKVADKIVMIDELERKLMESEDNCHDLKERLDKIMEYTMAKPNTSVEEEVATQTSPVKVGKDDVKEVKEVCDGNSQTTSPSTASQSNQTSFIESVDHKSLQTSFSIDSDRVDVIESLLEEERNKFFEMEAKYKEELERVTELSDELENVKNRLVKMEVVEKSSEFNEKKISEYLAEIETLKATIEELEGQNESLKTSRDYYRSDLGNIEKELSEAKKKVVRFTSELNEKENVKAELERKLEEYEQRVEGLREENVKLMELKEACESELKKKEEELAEARNKIDFIKNDLEVKERLASSVEKELEAKKELERQIEELNGEINRISEKNKVLQKSKEESNAMDKLKEELSAKQQELEKAKKELEGKIEELEKTLGEKDREINDLQKEIKDSIKLQANDVTEKELKLMIKERDEAKEKLSELDKLNKKLQTKINNMDRVIDELKKEVKKYKEEKDEFSNLEANYQKTIEGKEHELETFKKHQEETIKRYENLVKSKDDDLEKQKREVKKMQETFLVKGHNTPRDDFRAPSSDRSQYKLRENKPPKEETSEDESVTERRGRRARKVLEPTSPIPNVTIDEISETESTRSLRKTTAKACPSTGRKTRGRRLYTAVEDGVIAIEMTPENAPSPSPTPSTRSLRTRRNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HKZ2</accession>
    <name>A0A8J2HKZ2_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DMA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HICCMSTLAB_LOCUS10307</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DMRT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5101234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HKZ2"/>
    <dbReference type="OrthoDB" id="6162476at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd14417">
        <property type="entry name" value="CUE_DMA_DMRTA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005173">
        <property type="entry name" value="DMA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052145">
        <property type="entry name" value="Mediator/Homeobox_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24330">
        <property type="entry name" value="HOMEOBOX PROTEIN BARH-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24330:SF19">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03474">
        <property type="entry name" value="DMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DMA" evidence="4">
        <location>
            <begin position="325"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="68"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="132"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="428"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="266"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="73"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="106"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="141"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="432"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="444"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAG5101234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="461" mass="51329" checksum="AA78AB22E691887C" modified="2022-05-25" version="1">MINSSIWRFRAIALKACEKNSKTPRILRENPCNTPWTLHENTTLSILIENTDNTLLTHESSKRLRLSINDSSNEDHDSDSLDARESSKARSRSRSRSRSLSASRTPHMNTSTNSNIGAMVADTDSIVGMKQENSVHDSDDGSTGHTSLSPSHTPSLTSVFTPQRNDTPAPENLSLRKTASPIQIPSQTVSQAVNLVQTRYSPPPSSLTAAAAHFTPYLSLYGPTASSLYCSPTLYQHQHHHHLAEPRDMQMQMQMQMQNVQQSCSIQVQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQHQQQQQQQQQRSPIDVLLRVFPGRRRADVEALLHRCKGDVVSAMEVLVCEDSIQPKSAFSPLAGALASAAAVSAASAASAGNYTSRTAYCGPSPPTRHRFLAAPYAGTGYLPTVIRPPNQTNHSNGTSEVYRETSPDDASDKTSYSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HL58</accession>
    <name>A0A8J2HL58_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS12510</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5106938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HL58"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5106938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="110" mass="11818" checksum="FB96E32DD196A3A0" modified="2022-05-25" version="1">MLTLVLAFAPSPTDLSLMDKYLAFEFPGTQPLAQRRVPRGSATPVYIVVSVGSGDKISSAIGPGAPTTPSTALARIFAAHRQLRLSRELRFSLTGLDLCAPLQRISFSRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HLE0</accession>
    <name>A0A8J2HLE0_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS10597</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5101695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HLE0"/>
    <dbReference type="OrthoDB" id="6377396at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032589">
        <property type="term" value="C:neuron projection membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050808">
        <property type="term" value="P:synapse organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000533">
        <property type="entry name" value="Uncharacterized protein, isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037448">
        <property type="entry name" value="Zig-8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23279:SF6">
        <property type="entry name" value="DEFECTIVE PROBOSCIS EXTENSION RESPONSE 7, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23279">
        <property type="entry name" value="DEFECTIVE PROBOSCIS EXTENSION RESPONSE DPR -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ig-like" evidence="1">
        <location>
            <begin position="72"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5101695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="216" mass="23308" checksum="506F63B90E605E3B" modified="2022-05-25" version="1">MKRAAKVVSSSGAISWMRMKDIHILTSSLVTYTGDGRFSVKHPEGSDEWRLIIDYVQPRDAGLYECQVNTEPKLKMAFALRVEAAQATILGAEDVYVKKGSTISLTCKVNVQSTPPSSVTWHHGSAVVDFDSPRGGVSLETEKTESGTTSKLLVTQARSSDSGNYTCIPSNANPASVMVHVLNGEHPAAMQHGGSCRLTPTILMALLTIFTANLLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HLM9</accession>
    <name>A0A8J2HLM9_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Similar to LCT: Lactase-phlorizin hydrolase (Oryctolagus cuniculus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HICCMSTLAB_LOCUS10790</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5101988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HLM9"/>
    <dbReference type="OrthoDB" id="65569at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000013">
        <property type="entry name" value="lactase-phlorizin hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033132">
        <property type="entry name" value="GH_1_N_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001360">
        <property type="entry name" value="Glyco_hydro_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10353">
        <property type="entry name" value="GLYCOSYL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10353:SF36">
        <property type="entry name" value="LP05116P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00232">
        <property type="entry name" value="Glyco_hydro_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00131">
        <property type="entry name" value="GLHYDRLASE1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00653">
        <property type="entry name" value="GLYCOSYL_HYDROL_F1_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035189915" evidence="6">
        <location>
            <begin position="19"/>
            <end position="932"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAG5101988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="932" mass="108154" checksum="3DE0F3BBA08DD61E" modified="2022-05-25" version="1">MTKLIFLNLIFYLTVIQSNFHVHGNDITCADHFTDNTIKNTFPKNFIFGVSTSAYQIEGAWNVNHKGESIWDTMTHERPDKIADGSNGDIADNSYYLYKTDIDLVKQLGASAYRISISWTRILPNGTSNYINKDGIDYYNNVINEMLDRNITPYVTIFHWDLPQKLQDLGGWTNPKIVDWFVDYARVLFQEFGDRVSTVGIVVAMMVEVPENASDPEELAGSKFSWDFWNGWIINPIFSNDGDYPKAMKDRIAEYSAIQGFSKSRLPEFNPEQIQLVKNSADYFGFNFYSAFYIEKMKNYDIRSSVSRDRDVGMTMSLKKFPKDRNTPWAMAESLKRINENYNIPYFLITENGYWDKGTLYDTDRAQYYLDHLQVVSNLINQGLDIRGYFAWSLLDNFEWWQAIQSNFHVHGNDITCENNFTNKISENTFPDDFIFGVGSSAYQIEGAWNVNNRSESIWDTMAHLKPSKIFDGSNGDVADNSYYLYKTDIDLVKQLEANAYRISISWTRVLPDGTSNYVNKDGIDYYNNVINYMLTKNITPHVTIFHWDLPQKFQDLGGWTNPKIIDWFVDYARVLFQEFGDRVQYWTTFNEPNIFCRLGYNGILAPGLKESGRSDYICGHHALLAHAKTYRMYKEEFYEAQKGAVGIVVSAMLPVAEDATDPEEVEGVKLSWDFRNGWIINPIFSNDGDYPKTMKKRIAEYSAIQGFSQSRLPEFTPEQIQLVKNSADYFGFNFYSAGYFKKIENHNINSSVSADRDVGMTSSSKKFSKDRNTPWAMTESLRRINKDYNVPYFLITENGYWDEGTLDDTDRAQYYLDHLREVSKLINQGFDIRGYFAWSLLDNFEWVFGYMQKYGLFAVNYTDPNRQRTPKFSTKIITKIYKTKTVPSSIYDSNEQSQNKTKNVWSWSWSYSNTSSCFLGFIFTIFLTNKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HLN5</accession>
    <name>A0A8J2HLN5_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Tyr recombinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS11136</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5102692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HLN5"/>
    <dbReference type="OrthoDB" id="6760274at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="entry name" value="Intergrase catalytic core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="DNA breaking-rejoining enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="21"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="228"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="444"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="228"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5102692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="466" mass="53010" checksum="D4AAC72837EB956D" modified="2022-05-25" version="1">MDLNSEENSETEPCSELLDMIVEDASDGDSSDEDDGDNQEDYEAADNEDNEAVLIIGVCGATRRAEICGLTIDNVIDTGSKFVVTIQHVVKKIPVRRFSIEDDFYTLVKKYVSLRPVPKSPGQKMSNRFFLNYQKSKCTRQAIGINKIGGTPKRIAQFLKLSDANEYTGHCFRRTTEKLLKDVNVDMRSLSRYGEWKSCHVSLDDMNKIFSWITSEIKLKLLPVSPKPVKKFSKPKPKAVDQPTADQSNTEKSVVDEPINKSTSIIDKLVADEPIMDEPVANQPVSHPIVDQPVIEQPIVNEPIIDQPPIVEPITDLSSIDEPMTDDPIIIQSIEASTSKIIPQKVPTQFSKIKTKRIHYHTYKYSVVEIDRRRLEIVARGWTPLEGTQTVTSLGGFNDYQSAADWAEILDRRKTLDKQNWEFLQRHLENAAVDMDDIEEELEVKEEMTEKEEEEEEEEEEEEMCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HMW0</accession>
    <name>A0A8J2HMW0_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="19">Similar to Bumetanide-sensitive sodium-(Potassium)-chloride cotransporter (Manduca sexta)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">HICCMSTLAB_LOCUS10551</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLC12A transporter family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5101649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HMW0"/>
    <dbReference type="OrthoDB" id="2020542at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008511">
        <property type="term" value="F:sodium:potassium:chloride symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006884">
        <property type="term" value="P:cell volume homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055064">
        <property type="term" value="P:chloride ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055075">
        <property type="term" value="P:potassium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990573">
        <property type="term" value="P:potassium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055078">
        <property type="term" value="P:sodium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000022">
        <property type="entry name" value="Bumetanide-sensitive na-k-cl cotransport protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018491">
        <property type="entry name" value="SLC12_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002443">
        <property type="entry name" value="SLC12A1/SLC12A2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004842">
        <property type="entry name" value="SLC12A_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00930">
        <property type="entry name" value="2a30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11827:SF48">
        <property type="entry name" value="GH09711P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11827">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 12, CATION COTRANSPORTERS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03522">
        <property type="entry name" value="SLC12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01207">
        <property type="entry name" value="NAKCLTRNSPRT"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0868">Chloride</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0630">Potassium</keyword>
    <keyword evidence="4" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0915">Sodium</keyword>
    <keyword evidence="13" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="6" id="KW-0769">Symport</keyword>
    <keyword evidence="5 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="117"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="145"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="236"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="264"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="320"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="353"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="418"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="471"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="497"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="527"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="552"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="17">
        <location>
            <begin position="116"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="domain" description="SLC12A transporter C-terminal" evidence="18">
        <location>
            <begin position="617"/>
            <end position="1033"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="792"/>
            <end position="816"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF03522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="CAG5101649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="1033" mass="114468" checksum="C2B5C8FF4225BD12" modified="2022-05-25" version="1">MIIGAKVVTIATKSDNTENVTSTLITGMEGSFQNGSDEANNQNHINGKKSSMSLSVTGLWDVVPRMEYYRMSKRAKRPSLSDLHDGNPVKDTNVEAAIVNPGQAIHAGIKLGWIQGVLIPCLLNIWGVMLFLRLSWIVAQAGISWSLLIIGISALVCVITTLSLSAISTNGEVKGGGIYFIISRSLGPEFGASIGLVFAFANAVAASMNTIGFCESMNDLLKSHDLKIIDNGVNDIRIVGAIALFVMILICAVGMEWESKAQNFLIAIIVIAMFDFMIGTIIGPRDEVAKAEGFIGFSTEVFQKNWNSDYRHFENTTYNFFSIFAIFFPSVTGIQAGANISGDLKDPAKSIPIGTLLSLLISMISYVAFVLFAGGAALRDAGGFVNNTIVNCTPGIDCQYGLHNSFSVMQLMSVWGPFIYAGCFAATLSTALTNLLSVPRLIQALGRDRIYPGLIFFSKGYGKSGEPYRGYVLTFIVAAVFLLIANLNAVAPLISNFYLASYALINFCTFHAGLIRPLGWRPTFKYYNTWLSLLGFILCVAFMFLIDWVTSIITLVVIFGLYLIVVYSKPDVNWGSSTQAQIYKTALSVVYRLNVTDEHVKNYAPQILCLSGFPEKRPDLLHLANLITKHNSLLIAGEVCTASISYRARLARLRGGYEWLNRHRIKSFYQVISNLSFEKGASALMQAAGVGKLVPNVVLMGFKTDWAACNHKDLEEYFNILHTAFDQKLAVAMLRLPNGINTSNILNHVEEEQLVQSSYDLAGNTLMHADSDLSMSSRITRVQSVPVIGSHYLPGSESSGPAVRESPTNLSARDQLRNKKKHIADKLLYEKRNGILTEPQMITVFEKKHKNGVIDVWWLYDDGGLTILLPYIISTRSNWEHCKMRIFALANHKQESSAEEKEMAEIMAKFRIKYTSLKIVDDISVPPKQETQDFFDKLITDFRRQDDNDTTDCVITDLELQTLKDKTNRQLRLRELLLENSSKSTLVVMSLPMPRKGAVSAPLYMAWLETLTRDMPPTLLIRGNHASVLTFYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HP39</accession>
    <name>A0A8J2HP39_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="32">Protein deacetylase HDAC6</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="33">Tubulin-lysine deacetylase HDAC6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="37" type="ORF">HICCMSTLAB_LOCUS10986</name>
    </gene>
    <organism evidence="37 38">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="37" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="31">
            <text>N(6)-acetyl-L-lysyl-[alpha-tubulin] + H2O = L-lysyl-[alpha-tubulin] + acetate</text>
            <dbReference type="Rhea" id="RHEA:21548"/>
            <dbReference type="Rhea" id="RHEA-COMP:11278"/>
            <dbReference type="Rhea" id="RHEA-COMP:11279"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="31">
            <dbReference type="Rhea" id="RHEA:21549"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="29">
            <text>N(6)-acetyl-L-lysyl-[histone] + H2O = L-lysyl-[histone] + acetate</text>
            <dbReference type="Rhea" id="RHEA:58196"/>
            <dbReference type="Rhea" id="RHEA-COMP:9845"/>
            <dbReference type="Rhea" id="RHEA-COMP:11338"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="EC" id="3.5.1.98"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="30">
            <text>N(6)-acetyl-L-lysyl-[protein] + H2O = L-lysyl-[protein] + acetate</text>
            <dbReference type="Rhea" id="RHEA:58108"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:10731"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="30">
            <dbReference type="Rhea" id="RHEA:58109"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="8">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell projection</location>
            <location evidence="7">Axon</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Cell projection</location>
            <location evidence="4">Dendrite</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Cilium basal body</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
            <location evidence="5">Cytoskeleton</location>
            <location evidence="5">Microtubule organizing center</location>
            <location evidence="5">Centrosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Perikaryon</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the histone deacetylase family. HD type 2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="37">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5102380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HP39"/>
    <dbReference type="OrthoDB" id="424012at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030425">
        <property type="term" value="C:dendrite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000118">
        <property type="term" value="C:histone deacetylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043204">
        <property type="term" value="C:perikaryon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141221">
        <property type="term" value="F:histone deacetylase activity, hydrolytic mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040029">
        <property type="term" value="P:epigenetic regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051646">
        <property type="term" value="P:mitochondrion localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051129">
        <property type="term" value="P:negative regulation of cellular component organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032886">
        <property type="term" value="P:regulation of microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000342">
        <property type="entry name" value="Histone deacetylase 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.800.20:FF:000005">
        <property type="entry name" value="histone deacetylase 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.20">
        <property type="entry name" value="Histone deacetylase domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000286">
        <property type="entry name" value="HDACs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023801">
        <property type="entry name" value="His_deacetylse_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037138">
        <property type="entry name" value="His_deacetylse_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001607">
        <property type="entry name" value="Znf_UBP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625:SF38">
        <property type="entry name" value="HISTONE DEACETYLASE 6, ISOFORM G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625">
        <property type="entry name" value="HISTONE DEACETYLASE HDAC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00850">
        <property type="entry name" value="Hist_deacetyl"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02148">
        <property type="entry name" value="zf-UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01270">
        <property type="entry name" value="HDASUPER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00290">
        <property type="entry name" value="ZnF_UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="Arginase/deacetylase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50271">
        <property type="entry name" value="ZF_UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="25" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="28" id="KW-0966">Cell projection</keyword>
    <keyword evidence="22" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="26" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="19" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0488">Methylation</keyword>
    <keyword evidence="27" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="38" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="16" id="KW-0677">Repeat</keyword>
    <keyword evidence="12" id="KW-0678">Repressor</keyword>
    <keyword evidence="24" id="KW-0804">Transcription</keyword>
    <keyword evidence="23" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="14" id="KW-0808">Transferase</keyword>
    <keyword evidence="21" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="18" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="20" id="KW-0862">Zinc</keyword>
    <keyword evidence="17 34" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="UBP-type" evidence="36">
        <location>
            <begin position="904"/>
            <end position="1002"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="35">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="35">
        <location>
            <begin position="841"/>
            <end position="891"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="35">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="35">
        <location>
            <begin position="841"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="35">
        <location>
            <begin position="853"/>
            <end position="862"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="35">
        <location>
            <begin position="863"/>
            <end position="876"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00004484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00004489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00007738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="29">
        <source>
            <dbReference type="ARBA" id="ARBA00048287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="30">
        <source>
            <dbReference type="ARBA" id="ARBA00049136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="31">
        <source>
            <dbReference type="ARBA" id="ARBA00050910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="32">
        <source>
            <dbReference type="ARBA" id="ARBA00068733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="33">
        <source>
            <dbReference type="ARBA" id="ARBA00082852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="34">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="35">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="36">
        <source>
            <dbReference type="PROSITE" id="PS50271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="37">
        <source>
            <dbReference type="EMBL" id="CAG5102380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="38">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="1015" mass="113853" checksum="6C468BDBD60DF4C1" modified="2022-05-25" version="1">MSTKQKSWTNNKNKSSLSKVRPSSEIIAAKRKAAAEQKLKLLQTKVPDINFIYDIYQSAMDSRLLTRGETGLVYDDSMAEHQCLWDKNYPECPQRLTRTLERCKELGLIDRCKKISPRLATNKELLLKHSRKQIDILKATDGCTDLTKLEDLSSKYDAIYVHPSTYKLSKLAAGSTINLLQAISIAVESMLSEGLAKKVLIVDWDVHHGQATQQMFYDDPRVVYFSIHRYEQGEFWPNLRESDYHYVGEGKGIGYNFNIPLNKTGMTNADYLAIFQQVLLPMAYEFQPDLIVISAASGKVAVILEGGYCLESLSESAALTLRALLGDPCPMISTTLDLPSASIRETILNVIYAQKPYWSCYEFQDIYSIHSEDTKECDRHLPEIVFKGNETKLTVYETRNCYPIQSEIFLNDIRNQLLSLQLTTKLNKAPHRVSLVYDERMLKHCHPTDMRHPEIPQRISGIFSKHEEYDLLKRCHRIPGRIATEEELLLVHTESYVESMKTTEKKKMSEVHKESRNFESVYLHTETWSSASVAAGSVLQVVDSVLNGESQSGVAIVRPPGHHAERDAACGFCIFNNVSIAARYATEFHGCKRVLILDWDIHHGNGTQAIFEEDPQVLYISIHRYDNGSFFPSSEQANYNIVGSGKGEGFNVNIPWNRKKMGDTEYIAAFQQIIMPIAYQFNPELILVSAGFDACVGDPLGGYSVSPVAYGHFTHWLSSLANGRLILVLEGGYNVNSISYAMTMCTKALLGDPLAPITRSTAALSTSAITSIKNVLKTHKPYWSNLVYQAALPKENVIPQPVSLKFDMSPGVESKILQEEWQTEKNGIHQLSKEMGGLNVNQSEQGKQCSDSQEQKSGKVEEQPGCSSSQSKPGSSRVNPTDSGNPHEDKPLMDSMMFAIIPLSYCPHLELIAEVPAEGIDVKAPCKECNSTAENWICLHCYGVNCARAVNQHAILHGQDEGHPLTLSFTDLSVWCYGCEAYVDNPRLHAAKSAAYLSKFNEELPWTYDEPRIEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HP60</accession>
    <name>A0A8J2HP60_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Similar to Tlr13: Toll-like receptor 13 (Mus musculus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HICCMSTLAB_LOCUS12141</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5106199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HP60"/>
    <dbReference type="OrthoDB" id="2013775at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026906">
        <property type="entry name" value="LRR_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24366">
        <property type="entry name" value="IG(IMMUNOGLOBULIN) AND LRR(LEUCINE RICH REPEAT) DOMAINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24366:SF96">
        <property type="entry name" value="LEUCINE RICH REPEAT CONTAINING 53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13306">
        <property type="entry name" value="LRR_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="4" id="KW-0675">Receptor</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035248834" evidence="3">
        <location>
            <begin position="19"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG5106199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="303" mass="34212" checksum="4B8966479029BC10" modified="2022-05-25" version="1">MILKSAFLFLILSSVSTASNGPAIAFDFANKNITSLDGRFYETSKLTFIHAPYNKISKVDSSLFAGLPNLYSLDLTANPIDWLNLNLTNLGRLVLDGALRNFSESFGKMQLSIGAKPGVGVSTVLYLPTLRELYLRYNRITQIDGLTEETVPNLVYLDLSYNDIEYLDFLDKLPKSIAHLCLNNNKILKFVHERMPVKSLGLYAVAETVIEKYDFNHLENLQYLDISRNKIEKIEDGTFKNLSKLITLYLNNNYLSSLPDFSGLTHIKKLDLSNNYLSPISATAFDYLPTLEELNTFGNSDEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HPG0</accession>
    <name>A0A8J2HPG0_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">Zinc finger protein-like 1 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HICCMSTLAB_LOCUS12367</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Membrane</location>
            <topology evidence="1 11">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the ZFPL1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5106653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HPG0"/>
    <dbReference type="OrthoDB" id="1916590at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd16487">
        <property type="entry name" value="mRING-H2-C3DHC3_ZFPL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058730">
        <property type="entry name" value="U-box_ZFPL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039043">
        <property type="entry name" value="ZFPL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058731">
        <property type="entry name" value="Znf-B_box_ZFPL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12981">
        <property type="entry name" value="ZINC FINGER PROTEIN-LIKE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12981:SF0">
        <property type="entry name" value="ZINC FINGER PROTEIN-LIKE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25998">
        <property type="entry name" value="U-box_ZFPL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25993">
        <property type="entry name" value="zf-B_box_ZFPL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7 11" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 10 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="277"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="12">
        <location>
            <begin position="53"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU369078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAG5106653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="325" mass="36753" checksum="CC1E18402469561B" modified="2022-05-25" version="1">MGLCKCPKRKVTNQFCFEHRVNVCEHCMVTNHPKCVVQSYLQWLQDSDCNPICTLCSNELKSGDCVRLVCYHVYHWPCLDQHARSLPSTTAPAGYVCPTCNYAIFPAPNLVSPVADVLKEKLASVNWARAGLGLPLLSNDRETSIPESKVPSIETTVYQNHASPPIPSVATARTSSNVNSISTHINNVHSINNNSNNHQSQGPPYSVVNMESTSQLDRKIFETRDDSKNMSFDHDENKYERRSPIKRLLHIWKLLKLSKLSETRRRGSKPESVYRRYLILAVIGIVCFLFIIMIFSWLGRMATDGDPSFELKNNPNLNLHQEPAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HPS4</accession>
    <name>A0A8J2HPS4_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Similar to Zasp52: PDZ and LIM domain protein Zasp (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HICCMSTLAB_LOCUS13242</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5108448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5911912at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005912">
        <property type="term" value="C:adherens junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031941">
        <property type="term" value="C:filamentous actin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001725">
        <property type="term" value="C:stress fiber"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030018">
        <property type="term" value="C:Z disc"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051371">
        <property type="term" value="F:muscle alpha-actinin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007507">
        <property type="term" value="P:heart development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061061">
        <property type="term" value="P:muscle structure development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08368">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09455">
        <property type="entry name" value="LIM1_Enigma_like_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09461">
        <property type="entry name" value="LIM3_Enigma_like_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd23068">
        <property type="entry name" value="PDZ_ZASP52-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.42.10:FF:000055">
        <property type="entry name" value="PDZ and LIM domain protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000020">
        <property type="entry name" value="PDZ and LIM domain protein 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000060">
        <property type="entry name" value="Uncharacterized protein, isoform Z"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000069">
        <property type="entry name" value="Uncharacterized protein, isoform Z"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000073">
        <property type="entry name" value="Uncharacterized protein, isoform Z"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031847">
        <property type="entry name" value="PDLI1-4/Zasp-like_mid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050604">
        <property type="entry name" value="PDZ-LIM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006643">
        <property type="entry name" value="Zasp-like_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24214">
        <property type="entry name" value="PDZ AND LIM DOMAIN PROTEIN ZASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24214:SF38">
        <property type="entry name" value="PDZ AND LIM DOMAIN PROTEIN ZASP-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15936">
        <property type="entry name" value="DUF4749"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00735">
        <property type="entry name" value="ZM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00478">
        <property type="entry name" value="LIM_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6" id="KW-0440">LIM domain</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="PDZ" evidence="9">
        <location>
            <begin position="6"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="LIM zinc-binding" evidence="8">
        <location>
            <begin position="267"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="domain" description="LIM zinc-binding" evidence="8">
        <location>
            <begin position="1853"/>
            <end position="1912"/>
        </location>
    </feature>
    <feature type="domain" description="LIM zinc-binding" evidence="8">
        <location>
            <begin position="1913"/>
            <end position="1968"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="88"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="213"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="360"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="450"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="538"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="657"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="839"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="883"/>
            <end position="975"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1009"/>
            <end position="1051"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1090"/>
            <end position="1115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1205"/>
            <end position="1268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1280"/>
            <end position="1341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1358"/>
            <end position="1380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1635"/>
            <end position="1667"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1720"/>
            <end position="1762"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="93"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="251"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="360"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="458"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="500"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="556"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="683"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="883"/>
            <end position="949"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="953"/>
            <end position="970"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1009"/>
            <end position="1034"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1098"/>
            <end position="1115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1207"/>
            <end position="1219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1244"/>
            <end position="1254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1358"/>
            <end position="1379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1658"/>
            <end position="1667"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1721"/>
            <end position="1743"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAG5108448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="1968" mass="218203" checksum="561CF0FCE1D6CB7A" modified="2022-05-25" version="1">MAQLISVKLSRFDGSPWGFRLQGGKDFGTPLIVQKVNGGSPAEAAGLKAGDAVIRVNNTDMFNLRHKDAQDVIVRSGNNFEITVQRGGSTWRPSVSPVSQSIPSPQPHLSAGSVSPVTKTSLAAKKTDGHLIGSGHNFSPKPYPNGTSEGPIKSIVNKQYNSPVGIYSEQTIAETLSAQAEVLAGGVLGVNFKKNEKNYTPENSEVFKMVREADKEPKTPEPTDSAIHSGVVTPSSPALTGLRSVSAPETKPQPTPPPQSSLPPGQNICAECERLIVGVFVRIKEKNLHVECFKCSTCGTSLKNVGYYNINSKLYCDIHAKLVARQQAPAGYIPVTVSPGAKAPASTISAALGNFQSQSPMSPTPFSNGTSSTPSFSRRKTFYRPPSSSSSYTVDYCGVSSQPVDRTSTYESLPSETNYRSMVKNEAVNNQQNNYKTYTSTITIRTGSEVGNKDYYSDDTNNTPSHLGSSPRADKSPSSSLVQANISGPKPFSGSSNFGPTSNFTSTPTSNSVNNNFSRPQSQTVTESYHAEYNYLEEKDIKGTPAPSTADEYSRPPSSVRNKSLQWPPVKSLEDATYPTASPIWIDPNPVLDRRSRHIVQDRQVELNENACRRSESVNRRREANRREEFSHCNWGEEPMENKPVCSAPFYRKTTTTECSEVRQSRSSSLNRPGSAEGVRRSLTPTRISQPVPQPWTGSTELSSYRHVQAPVPPEPPICRKVCTCEIICERITGPGGPEHQQDHVYREVKCELCNPPPCMQVTDYDQEQEIEEPCEILEQQTDSEVVDLSKVVPPDVAVCPKGVENQHNMHTEIMEKDEGNIHIKKTTIYEKTVEIVSPSESPANDNEVENWSGRRQHVESADKISSFIETKKMIEEARQEELKHREAYEEECRREEEKMRRVQEEEERREANRLKILQAEKEEKERRIKEQKRETEMRIRQEEEERFGKHVSFSQNQSCDYQNQNNSRIMSAEQHYRELKEEIKVQDTERTEQERRETLRQQVEIHKCLREQQAPERRQQQSNLQERRIEKRFRPQSPPHESSSSACQRKHVQFVKQTESGTCQMQTPVQNSTPKEWKSEMVKALTTAPTRPYSPLHPSNMQTGGQHYQEDNSCSSKTMYSSEVRYEETCRSFPPPPQPPQPYVPRPGSPFADALTIAPERPYTPLGERSVKGCENVICVDREDTPINQSTPQGYCHPAEILYTDSTERQSRSRERNLSRVQGPRPLPTPPTNYKFRDASPSPARTLSRSTTPRDPGLPAALKRPDTIPSYQKHLITEDYDPIDAQPYVPSRSPTPCRSKSPAPGPAYLPNPLQHNLGRKPYHSNVPSYDQPSSESYSYKAQSASASASYSCPEQQSKQVTYRAQPQQSETPKNQYSENYGMRSYVSEDHSEKQCSRTSYAEKYKRIEEKQLEACRQSEMQLSKSEESLVDDSTCTISKVSRNPPSLPCPVVASHSSVSERIQRTGVRVLPTPCETTTASYQVCESRPICHSQNESKCPNTGVTILPCRAVSDAGSRAGIVIVPCEGSDAQCPQTGVRITPTPDRGLCVSPVAHGRSSGSCYGSDNPRAGGCAIDVGNCPGSGVKVGTCADGSVCVAPCKTSGCPKPILKCPAKPVPFPHIPLPQPEDVGCSSCPLKNQQESNPPNSNNSFKPINGQPRTNLSNQLTRLTVRRDKQVVQLFKPQPQSQPCTDGVHCQPNVNRSCSDGVHCEPDPYRSLAPQLNPNPFSASSNPDPFRKTQNLVDPPNFSDPNLGSGVGGPSSGGNCKFAGSSAPKRGRGILNQAGAGGRQPLCGFCNSYVRGPFITALGQIWCPEHFVCVNTQCRRPLQDIGFVEEKGQLYCEYCFERFIAPSCNKCNGKIKGDCLNAIGKSYHPDCFSCAYCGKIFGNSPFFLEEGLPYCEADWNELFTTKCFACGFPVEAGDRWVEALNNNYHSQCFNCTMCKKNLEGQSFYAKAGRPFCKNHAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HR66</accession>
    <name>A0A8J2HR66_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS13775</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5109139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HR66"/>
    <dbReference type="OrthoDB" id="275011at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5109139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="39" mass="4519" checksum="923973A43FE18F60" modified="2022-05-25" version="1">MLLMERIPDQVGYLVLTQDGAVLATPKQYHQLTRSIKYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HR85</accession>
    <name>A0A8J2HR85_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Similar to bab2: Protein bric-a-brac 2 (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HICCMSTLAB_LOCUS11698</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5103815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HR85"/>
    <dbReference type="OrthoDB" id="7956040at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18315">
        <property type="entry name" value="BTB_POZ_BAB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051095">
        <property type="entry name" value="Dros_DevTransReg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23110">
        <property type="entry name" value="BTB DOMAIN TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23110:SF108">
        <property type="entry name" value="LD19131P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="4">
        <location>
            <begin position="46"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="129"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="354"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="138"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="360"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAG5103815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="394" mass="44099" checksum="7679AE6A33E62AB6" modified="2022-05-25" version="1">MEPGNNLPPPGTYPDGDRQQLCVSWHSYQSNMHNAFPKLLSSEQFVDVTLACDGGSIKCHKVVLSACSDYLERLLLEIPCSHPIIFLRDMRMWELQALVEFMYRGEVYVEQQQLAKLMQAADVLQIRGLSGQTRDANPETSTPPSVSSTHSEPTTPIKKTPQVPAVKEIIEDEEDDEEDDAPTQNDDPMTFLENSINVTLNAINNTSLTVTPTDPPVSEPSNFLTIDHTENIEHTEALQHLEKALSSCEATMTETPGMVKMEPDEQFFQQDKPYSISMVPTSNNCNTTNNSNSNSPFPAIEGYQRRQRRSEAELKLASDMVARGKTFQVASEKYNIPISTIRFYMVRKGLLQRRKRGRGSTNIGASNSQPGSPATPPFHMMNYRLPESLNSTLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HRI7</accession>
    <name>A0A8J2HRI7_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to T: Transposable element P transposase (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS13062</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5108087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HRI7"/>
    <dbReference type="OrthoDB" id="6485269at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048367">
        <property type="entry name" value="TNP-like_RNaseH_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47577:SF2">
        <property type="entry name" value="THAP DOMAIN CONTAINING 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47577">
        <property type="entry name" value="THAP DOMAIN-CONTAINING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21789">
        <property type="entry name" value="TNP-like_RNaseH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transposable element P transposase-like RNase H C-terminal" evidence="2">
        <location>
            <begin position="107"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="209"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="216"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF21789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5108087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="407" mass="46422" checksum="98E6372643DEAE95" modified="2022-05-25" version="1">MTQAIQTLLKFLEDWEKMHSNVKIQNVSTPKNSTKKNLVPNQTPQNPSTPKNLNLNKTTPKSKSKKRDFPISSSSISGFKVTLRAALEISSELHKNYGYEYLLTSRLTQDNLERLFSIMRYSCGSNDHPTPQQFGQVFRLYCCNAMIKPPKGTNVTGVELLQTLMKTKDTLETSREPRVEWLKKIDQMLENAVPIDDLWNNNSSNNVSDIADSEEGLNNQSQEASIDLNSSEQSTQLTLRTDGCLEDHDYDVVSTSKEVQAYMAGYIVRKLKLKCKCLLCLNTLQLSDNELNSRDRFIDLMEKYGGLSRASDDLFKLTEQLEAAFLDVVGRVGLSRGIIYKILDRIETKLPKLSFVGCAIHQLEITKNIIDFYVTMRLHFLGRTFNKRNQLKREKMKALKKTSKLVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HRS5</accession>
    <name>A0A8J2HRS5_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Radial spoke head protein 9 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HICCMSTLAB_LOCUS13244</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell projection</location>
            <location evidence="8">Kinocilium</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Flagellum axoneme</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the flagellar radial spoke RSP9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5108452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HRS5"/>
    <dbReference type="OrthoDB" id="10258956at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060091">
        <property type="term" value="C:kinocilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001534">
        <property type="term" value="C:radial spoke"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035082">
        <property type="term" value="P:axoneme assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060294">
        <property type="term" value="P:cilium movement involved in cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044458">
        <property type="term" value="P:motile cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006802">
        <property type="entry name" value="Radial_spoke"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055316">
        <property type="entry name" value="RSP9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22069">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOMAL PROTEIN S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22069:SF0">
        <property type="entry name" value="RADIAL SPOKE HEAD PROTEIN 9 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04712">
        <property type="entry name" value="Radial_spoke"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0966">Cell projection</keyword>
    <keyword evidence="5" id="KW-0969">Cilium</keyword>
    <keyword evidence="3" id="KW-0970">Cilium biogenesis/degradation</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4" id="KW-0282">Flagellum</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00037822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00041080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAG5108452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="233" mass="26498" checksum="0BBD40EA613BF930" modified="2022-05-25" version="1">MEYNKLSESIDTVGYSGVCIGTERSQLLKNSLLVLGKENNFDKIYYWGRINGIERDYYIAYGHGKDYLRNQTYYYSFNCLDWLLLPKATKTDKVISSFLMNYFQGDPSVKTSAQVPDFFLSDGETSKKSIENGVTSCEIKEEDRLSATVDLINNDSIIIPRGSWIKHPSGDVGKNPAFTGLNLNECLELKSYLHARLPLRKSDMNLIKKQDYNNCALDFLDSIDMDLSKGKCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HU56</accession>
    <name>A0A8J2HU56_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="13">6-bisphosphatase (Lithobates catesbeianus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HICCMSTLAB_LOCUS13682</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">In the C-terminal section; belongs to the phosphoglycerate mutase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5109046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HU56"/>
    <dbReference type="OrthoDB" id="267323at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003873">
        <property type="term" value="F:6-phosphofructo-2-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004331">
        <property type="term" value="F:fructose-2,6-bisphosphate 2-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006003">
        <property type="term" value="P:fructose 2,6-bisphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006000">
        <property type="term" value="P:fructose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1240:FF:000001">
        <property type="entry name" value="6-phosphofructo-2-kinase/fructose-2, 6-bisphosphatase 3 isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000047">
        <property type="entry name" value="6-phosphofructo-2-kinase/fructose-2, 6-bisphosphatase 3 isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003094">
        <property type="entry name" value="6Pfruct_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013079">
        <property type="entry name" value="6Phosfructo_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001345">
        <property type="entry name" value="PG/BPGM_mutase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10606:SF44">
        <property type="entry name" value="6-PHOSPHOFRUCTO 2-KINASE_FRUCTOSE 2,6-BISPHOSPHATASE LONG FORM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10606">
        <property type="entry name" value="6-PHOSPHOFRUCTO-2-KINASE/FRUCTOSE-2,6-BISPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01591">
        <property type="entry name" value="6PF2K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000709">
        <property type="entry name" value="6PFK_2-Ptase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00991">
        <property type="entry name" value="6PFRUCTKNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00175">
        <property type="entry name" value="PG_MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="6-phosphofructo-2-kinase" evidence="12">
        <location>
            <begin position="34"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="455"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-phosphohistidine intermediate" evidence="9">
        <location>
            <position position="258"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="9">
        <location>
            <position position="327"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="257"/>
            <end position="264"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="307"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR613078-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR613078-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAG5109046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="474" mass="54842" checksum="957A8C10FFBE38AF" modified="2022-05-25" version="1">MSKMTDRKTEGHYTPPTSDTIQTKPFPIRGERENFVNKPHVIAMVGLPARGKTYISKKLCRYLNWIGINTKVFNLGEYRRHATTAYKCHDFFRPDNIKAMAIRTQCAVDALNDVCHWLESGDGEVAVFDATNSTTERRQMIHDIVVEKMGFKLFFVESICDDPEIVEQNIMEVKVSSPDYANMNKEEVLADFTLRIEHYQEKYEALDESKEPNLSFMKIYNTGEKVLVYKHEGHIQSRIVYYLMNIHIVPRTIYLTRHGESMMNLEGRIGGDPDLSDRGRQYIKALAEYIDEQDIQNLRVWTSWLKRTIQTAADVNAPQERWKALNEIDAGICEEMTYEEIASKYPTDFAARDQNKFSYRYPRGESYEDLVARLEPVIMELERQGNVLVVTHQAVLRCLLAYFLDKNSENISLLDELPYLQVPLHTILKLTPVAYGCKVERIRLPIDAVDTHRPKPKVEAKSNEIVKKNDNSVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MD52</accession>
    <name>A0A8J2MD52_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Olfactory receptor 173</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HICCMSTLAB_LOCUS3563</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5082443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MD52"/>
    <dbReference type="OrthoDB" id="6604226at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005549">
        <property type="term" value="F:odorant binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004984">
        <property type="term" value="F:olfactory receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004117">
        <property type="entry name" value="7tm6_olfct_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21137">
        <property type="entry name" value="ODORANT RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21137:SF35">
        <property type="entry name" value="ODORANT RECEPTOR 19A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02949">
        <property type="entry name" value="7tm_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0552">Olfaction</keyword>
    <keyword evidence="8 11" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="9" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="110"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="150"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="278"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="306"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAG5082443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="403" mass="46799" checksum="CB2FB0227970D6B4" modified="2022-05-25" version="1" fragment="single">MSNSSMPLYKKCINFFLRALSFFVLVSYILTSLADLVVNHHDITIIVDDTCFIAGAGSAFFKICIVIFRCQTIDKLINDIHNPIDILQQSNDKGAIKIIKKCIFFETLDYYLWSNATFVLGFATIFLVTSQKGELPSRAIFPFDITKPSFYAIALSIQFYTVIYGLISLMMIEITLWGLLRWTTVQIEVLSYNYKNCNRYLSIQKSYSPETKLAVKKSPVYDPEDEEMEIKQFLLFDDDKHDAVEINCFQWRIRYCIKHHQRIVDIINRLNDTLSSCLMAQFAVSTLIFCLNGFLAVTFPHDKKRLMRSIFFLLVGFIQIFYWCRFGNELKFQADYLTTSQWMSGWENNFNSELRNYITVAMIRTMKPVEIKAGGLFVLSMETFLSILKNSYSVFVLLTTVEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MFT6</accession>
    <name>A0A8J2MFT6_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Similar to Cpn2: Carboxypeptidase N subunit 2 (Mus musculus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HICCMSTLAB_LOCUS5274</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5089532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MFT6"/>
    <dbReference type="OrthoDB" id="8400687at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004180">
        <property type="term" value="F:carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000770">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000483">
        <property type="entry name" value="Cys-rich_flank_reg_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050333">
        <property type="entry name" value="SLRP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45712">
        <property type="entry name" value="AGAP008170-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45712:SF22">
        <property type="entry name" value="INSULIN-LIKE GROWTH FACTOR-BINDING PROTEIN COMPLEX ACID LABILE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00019">
        <property type="entry name" value="LEURICHRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SMART" id="SM00082">
        <property type="entry name" value="LRRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="7" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035204430" evidence="5">
        <location>
            <begin position="17"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="domain" description="LRRCT" evidence="6">
        <location>
            <begin position="378"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAG5089532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="467" mass="51965" checksum="1A2E899E563A4BA1" modified="2022-05-25" version="1">MNVWIVFLLCFGSGLAQTIARCPNPGDIRPCSCSVKKNGLDVICESTDHGYINKALTALKQQNSVIFYLKLRHNNLPKLPGFVFLGLIVQHLAIHNSTKGLTQLDLSQNSLATVPSPALANLHALIILNLNRNKIHELRSKSFAGLDTLEILSLYENKINSIDPDAFKGLDDRKLKRLNLGGNLLTNIPTPALSSLDVLKKLEMQENKISSIKEGDFEGLKGLDSLVLAHNQISEVPARVFSHLTQLNSLELEGNRITRVDPDAFIGLEENLQYLRLGENNLHVIPSDALRRLHRLRHLDLRSNNITALPEDAFAGYGDSISFLNLQKNLIKVLPPTIFDNLNSLQSLNLGNNKLIHIPEEITGGMIDTLVMIDITDNPLICTCDLQWFPYWLKKLKGQDDDTMSKKRTVCTMPNERREYVLQNLPLEKMGCVSKAGKISSSSNIIASNPTQILALHLAFCVTSILH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MGS7</accession>
    <name>A0A8J2MGS7_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similar to mask: Ankyrin repeat and KH domain-containing protein mask (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS2896</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001117">
        <property type="protein sequence ID" value="CAG5078986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MGS7"/>
    <dbReference type="OrthoDB" id="194358at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051616">
        <property type="entry name" value="Cul2-RING_E3_ligase_SR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46224">
        <property type="entry name" value="ANKYRIN REPEAT FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46224:SF64">
        <property type="entry name" value="IQ MOTIF AND ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="80"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="116"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="152"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="185"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5078986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="410" mass="45765" checksum="A37793ECD82BC447" modified="2022-05-25" version="1">MGKDRYLSLSDVNVVTVSELVNRRFFDFYALRKYDIGLDKPLSCTLLYAAVMNADEECVDLILPKLSSVFADKGGFFVKHHESAVHRALSYQDFSILRKLIEHGASVNDTDSVEHEGQPLLHFAVEKGYYEIAKYLVEKGADVNMPGHGSHCETTPLMEAVIGGSEDMVKLLVENGADVNAEDNEQDTPVTVAATSGKFEIMKLLLDHGARVDLIIPESKWNGKKSIINEVVCTGNVQVLKHLLDRFEVDLTVPTGDLACSTLAFAVMVRANNGPSIQELLDAGSDVNSLSYDNKLPIEMTRTFDLSDNKILVKKHVVKLMAAGQEVCEKNLEAVQDPEFADLRQECDAELEELKSTKLEGSNVTLFDILFGKVVKKKMKKVDVKKSMETLEDYPLYGRMLFYRLKKFRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MJ09</accession>
    <name>A0A8J2MJ09_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS7287</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5093961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MJ09"/>
    <dbReference type="OrthoDB" id="6415662at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013162">
        <property type="entry name" value="CD80_C2-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21261">
        <property type="entry name" value="BEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21261:SF15">
        <property type="entry name" value="BEATEN PATH IIIA, ISOFORM D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08205">
        <property type="entry name" value="C2-set_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ig-like" evidence="2">
        <location>
            <begin position="121"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5093961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="252" mass="28766" checksum="7D06B7595109F5CF" modified="2022-05-25" version="1">MRIDSRMAKLNQILLNQFAEVFSFRIKMYDLETEKLYSVLWYKDNEEFYKYVNTDKSQHIYQVDGIKVDHRNSDGQRVILQRVNLDTTGVYKCEVSAEAPHFASTYGEAYMEVVVMPSNTPKITGKEAFYASGDILSLNCTSEKSHPPAKITWYINNVEVEADSTRTIIHRDRLVTTISTLRLELGPHHLSSGESKVKCKSRVETSERAREALVDDRITEVAVRGSGNFIRPSLSLVLVAVIVLLDRIVRMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MJC7</accession>
    <name>A0A8J2MJC7_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Similar to Ss18: Protein SSXT (Mus musculus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HICCMSTLAB_LOCUS7637</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SS18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5095294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MJC7"/>
    <dbReference type="OrthoDB" id="10265171at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007726">
        <property type="entry name" value="SS18_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23107:SF0">
        <property type="entry name" value="IP09280P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23107">
        <property type="entry name" value="SYNOVIAL SARCOMA ASSOCIATED SS18 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05030">
        <property type="entry name" value="SSXT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0010">Activator</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="SS18 N-terminal" evidence="9">
        <location>
            <begin position="11"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="77"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="108"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="118"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="153"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="213"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="237"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="255"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="287"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="307"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="351"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="371"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="388"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="429"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="448"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="466"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="525"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="570"/>
            <end position="585"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF05030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAG5095294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="585" mass="60629" checksum="7B4B27582107D002" modified="2022-05-25" version="1">MSATFVQRGRVPPTPAQIQKMLDENSHLIQTIQEYQNKGKPQECLQYQQILHRNLVYLASIADANQNVQALLPPPQGIPPMTNGPQHGMMGPQGPPNVAPGTPGPGGEMPPNPPQPMPMQGFNQGQPMPQGGYRGPMPGQGPPMNRANPGPGPQQYRGGPQAYPQQPGQQGYPAGYGGQNPGGNYPQGPQGGAYGAGQPNQYPPNAPQQGYPASSQQNYGPPTSVNSYGGQPAYPNNVPPQNYPPPPATSNNVAQPSQGPPQQSQGGPPQNYASQPSPGGGPPAPYGPSSTSPPFSTSNVSGVNTYAPSNQPTSTPSASTQTYPPTSGPPPATSQAGSYVPGPTPSGYPVHQPSHQAHGPHGPHPGSHQIPHPPPSQAQPGPPPQSQPPGQSQQPPQQPPQQQQSQQQPPAQSPQQQQQQQGPPPQGPPQQQQSQQGAPQSQHQQSPSPVPSNFPPTSGPISQGPPSGPPGPPGPPQQPPGGYGPPQSHPATTQTYVPPGSGQPPQGYPTHPPGQGGQPHYGHPQYPPQNYPPHPPPPSGQGYPQYPPRGPPGGHMPPPPGPQGPPPPNQYAGYGYQQPPQICAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MJE8</accession>
    <name>A0A8J2MJE8_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS7698</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5095417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MJE8"/>
    <dbReference type="OrthoDB" id="16679at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5095417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="193" mass="21496" checksum="3674EBAEB4196356" modified="2022-05-25" version="1">MSNPTKMTSNVNFPGKSFTLVAVKPKGLSIRSRSELNIALPAKSSSAIKVDEAKKSTLTLFKDKVSKNVLQIQKQGLSPNSKSPHKEVSPVFKKPLPPKVNTHVYPPAEKLASSYGFKENFDRVLRRAEALDKEANELSAILKPANRIIKPFEDDLDREPLTIVIEKDYPRRSVVNEDLTCSDVEIPTLPDED</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MJY5</accession>
    <name>A0A8J2MJY5_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS4915</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5088625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MJY5"/>
    <dbReference type="OrthoDB" id="8250698at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5088625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="135" mass="15408" checksum="33C15DC788AB36A7" modified="2022-05-25" version="1">MEHKSESVEYKKYGIVLLRKRALIEGFSTKCRSEALKILVEEIASLIREEICLRRKRKEFLQNILRDYEKDPMLAVNSFSDEKGCEKGDNYASNITKTTIKGRSGCGKDQNNKKIAFETLGNSCDVVKCIPRAVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MKV1</accession>
    <name>A0A8J2MKV1_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS3686</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5082926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MKV1"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="143"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5082926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="229" mass="26549" checksum="4EBF887B78DD6D26" modified="2022-05-25" version="1">MPMQCEFTDLAKLICFISGEEFILARSSLSDPALAYQSIGPGSSPAYTNEYFQYLRVLFCSAQEIKRVPISKSLPPIVVAHDLSSLCDFKQIKKKKKMYTEKTTFNWFPCCTDPSSIYNGTRIRTTWKPVKCRFFRESDRKSFNFIDVISVTFLFGLRLVAYGYGGLKFLCKNFRHPAHLHRPHVRIMMDGCISYNYYERENRGSKLIVAIVENKRRMCIKITILITNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2ML81</accession>
    <name>A0A8J2ML81_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Similar to otp: Homeobox protein orthopedia (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HICCMSTLAB_LOCUS6851</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5093461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2ML81"/>
    <dbReference type="OrthoDB" id="6159439at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030182">
        <property type="term" value="P:neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003654">
        <property type="entry name" value="OAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051895">
        <property type="entry name" value="OTP_Homeobox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46770">
        <property type="entry name" value="HOMEOBOX PROTEIN ORTHOPEDIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46770:SF1">
        <property type="entry name" value="HOMEOBOX PROTEIN ORTHOPEDIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50803">
        <property type="entry name" value="OAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 6" id="KW-0371">Homeobox</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="4">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="domain" description="OAR" evidence="5">
        <location>
            <begin position="195"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="2">
        <location>
            <begin position="3"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="129"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="142"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="177"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAG5093461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="235" mass="23541" checksum="5173747F0ED2BAA3" modified="2022-05-25" version="1">MYQVWFQNRRAKWKKRKKTTNVFRTPGALLPSHGLPPFGAMGSDLCGAAGMFHTPADRWAMGPGLGQLSQSSMGMASFGQSLGQLSQQTSGSLGSSLGLGNSTLPISSPSQTVYQATYGLNSLGGVHVTASRGSPPGASSVGTGGGQSSGGGLGGGGMNCGQGSPGAASGSGGGVSCVGSADGSAGEATDWRGAHSIAALRRRASDASQQYSPQPPPPSGPPQYSSHDLEYSSVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MLD3</accession>
    <name>A0A8J2MLD3_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">C1q domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HICCMSTLAB_LOCUS7001</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5093675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MLD3"/>
    <dbReference type="OrthoDB" id="10070467at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001073">
        <property type="entry name" value="C1q_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050822">
        <property type="entry name" value="Cerebellin_Synaptic_Org"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008983">
        <property type="entry name" value="Tumour_necrosis_fac-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22923:SF116">
        <property type="entry name" value="C1Q DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22923">
        <property type="entry name" value="CEREBELLIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00386">
        <property type="entry name" value="C1q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00110">
        <property type="entry name" value="C1Q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49842">
        <property type="entry name" value="TNF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="36"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="domain" description="C1q" evidence="5">
        <location>
            <begin position="84"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAG5093675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="207" mass="22062" checksum="24E448743F964606" modified="2022-05-25" version="1">MNHGIHFAQLISSQIIFSDICGEKKFQIVARKKSRLYCVISGLYSLLVWTVLLILTTSLLTNGARPDPPSSGITTVGSLKLANAEDCAGVVAFSATSGLKTNTRLKFSQTQVNKGVGYAAETGIFTTHCPGLYQFSLAGYGTADLKLTLKRKANRSDDWTPIVSTGIGGGSNLVFLDSEIGDQLAVFVDSGNPNEGTSFSGYRVAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MLL3</accession>
    <name>A0A8J2MLL3_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Microsomal glutathione S-transferase 1</fullName>
            <ecNumber evidence="5">2.5.1.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">HICCMSTLAB_LOCUS7258</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>RX + glutathione = an S-substituted glutathione + a halide anion + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16437"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16042"/>
            <dbReference type="ChEBI" id="CHEBI:17792"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:90779"/>
            <dbReference type="EC" id="2.5.1.18"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:16438"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="14">Homotrimer; The trimer binds only one molecule of glutathione.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the MAPEG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.18" evidence="5"/>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5093932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MLL3"/>
    <dbReference type="OrthoDB" id="193139at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.550:FF:000002">
        <property type="entry name" value="Microsomal glutathione S-transferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.550">
        <property type="entry name" value="Membrane associated eicosanoid/glutathione metabolism-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023352">
        <property type="entry name" value="MAPEG-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001129">
        <property type="entry name" value="Membr-assoc_MAPEG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040162">
        <property type="entry name" value="MGST1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10689">
        <property type="entry name" value="MICROSOMAL GLUTATHIONE S-TRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10689:SF6">
        <property type="entry name" value="MICROSOMAL GLUTATHIONE S-TRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01124">
        <property type="entry name" value="MAPEG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161084">
        <property type="entry name" value="MAPEG domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0007">Acetylation</keyword>
    <keyword evidence="9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="13 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="14"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="99"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="126"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00038540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00039397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00049385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="CAG5093932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="148" mass="17253" checksum="6BC17B563B7E2B46" modified="2022-05-25" version="1">MIPDYIREQNFRVFAWWSVVLVLKIFGSVALVGFWRHYKKIFLSPEDAKFIKGSKVVYDDPDVERCRRAHLNDLENILPWVISTAFWLTTSPDPSTAAFLIKTFAISRFVHTFVYAVVVVRQPARFLAFMVGLIITIYQCLATVYYYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MLL4</accession>
    <name>A0A8J2MLL4_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Dolichyldiphosphatase 1</fullName>
            <ecNumber evidence="3">3.6.1.43</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Dolichyl pyrophosphate phosphatase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">HICCMSTLAB_LOCUS6484</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Required for efficient N-glycosylation. Necessary for maintaining optimal levels of dolichol-linked oligosaccharides. Hydrolyzes dolichyl pyrophosphate at a very high rate and dolichyl monophosphate at a much lower rate. Does not act on phosphatidate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a di-trans,poly-cis-dolichyl diphosphate + H2O = a di-trans,poly-cis-dolichyl phosphate + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:14385"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19506"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57497"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="EC" id="3.6.1.43"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the dolichyldiphosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.43" evidence="3"/>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5092965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MLL4"/>
    <dbReference type="OrthoDB" id="302705at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047874">
        <property type="term" value="F:dolichyldiphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042392">
        <property type="term" value="F:sphingosine-1-phosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03382">
        <property type="entry name" value="PAP2_dolichyldiphosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.144.10">
        <property type="entry name" value="Phosphatidic acid phosphatase type 2/haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039667">
        <property type="entry name" value="Dolichyldiphosphatase_PAP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000326">
        <property type="entry name" value="PAP2/HPO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="PAP2/HPO_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14969:SF59">
        <property type="entry name" value="DOLICHYLDIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14969">
        <property type="entry name" value="SPHINGOSINE-1-PHOSPHATE PHOSPHOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01569">
        <property type="entry name" value="PAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00014">
        <property type="entry name" value="acidPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="Acid phosphatase/Vanadium-dependent haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="43"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="74"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="117"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="162"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphatidic acid phosphatase type 2/haloperoxidase" evidence="13">
        <location>
            <begin position="73"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CAG5092965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="235" mass="26785" checksum="EF24583B44403480" modified="2022-05-25" version="1">MAAVDDEYLHHVSSNIVNNNYQQNIKWIPLSVSLVEYPQGDSLGLGLALISLMPLALIVGFITLIAFRRDLHTICFFIGVIVTDIVGLFLKYTIKEARPMKRDVVYVEYGMPSTHSLLMWFFATYTALFVCLRWTIIGGCATVAVLVSYSRIYLQYHTISQVLCGFVVGIIMGVTWFFITHLVLAPFFPIIVSRLSEFLLIRDSTLIPNVLWFEYTNIRTEARARSRKLVSMKSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MM42</accession>
    <name>A0A8J2MM42_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Similar to Arr1: Phosrestin-2 (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HICCMSTLAB_LOCUS7699</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the arrestin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5095419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MM42"/>
    <dbReference type="OrthoDB" id="6500995at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001664">
        <property type="term" value="F:G protein-coupled receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002031">
        <property type="term" value="P:G protein-coupled receptor internalization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.640">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000698">
        <property type="entry name" value="Arrestin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014752">
        <property type="entry name" value="Arrestin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011022">
        <property type="entry name" value="Arrestin_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11792">
        <property type="entry name" value="ARRESTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11792:SF18">
        <property type="entry name" value="FI20035P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02752">
        <property type="entry name" value="Arrestin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01017">
        <property type="entry name" value="Arrestin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Arrestin C-terminal-like" evidence="3">
        <location>
            <begin position="66"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="219"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG5095419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="286" mass="31772" checksum="3AD4B0233AF89626" modified="2022-05-25" version="1">MEINVILRTNSPPVPLSNLSSVSPPATIQSDCNPQKTQILGSENEVVECDEFQPPHAVVEKRFLLNPGSIRLEVHLDRANYTHGEDVQVHVTVNNDSHKSVRRIEHGKFKNVVGAESERENCPLAPGTKFSKTYSLKPALISTKNWIALEYNYTKKEKEKCLASTIISPVYNEEDRNPYAINVSYYVQVKLLISLMCNVVSVKLPFTLMRPDPDPELSTFSPALPLKSPPVETSNANSGGEDKKKPLAVMETSIQANGNKVTTALVQVKQMADVNLKENNKLFEST</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MNE9</accession>
    <name>A0A8J2MNE9_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF4218 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS8394</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5096805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MNE9"/>
    <dbReference type="OrthoDB" id="8191915at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579">
        <property type="entry name" value="F5/8 TYPE C DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579:SF1">
        <property type="entry name" value="F5_8 TYPE C DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5096805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="512" mass="58704" checksum="EE1A8397B906D899" modified="2022-05-25" version="1">MMSSVWFGTGKLKNMNAYLTPFVTEVKELLKNGFTYTLNGQTYKKRVFTLMVVCDSVARPLVQCTTQFNGNYGCGLCLYPGESIEKGQGFARVYPVINGEFFGEGLRSHEQTLIHTEEKTQEKKKRIKRKSILCDIPNYDIIKNLDVDWMHCVALGVSRQFANLWFDSKNSGEAFYFGDKIDQVDSYIHSLSPTSDFSRIPRGLKDRVHMKAHELFVEHWALLVEGISILTKKSIMKSEIVYADKCLKEFIVGVESLYGKMYLSFNVHLLVHLAISVENWGPLFTHSAFIYEDFNQIIENSIKSLNGVSIQICDSFRLKCVIDRLRNICQNDLNNKQNQFLNRLLNKKSRPISNLQLGDCKVLGKPVILSNLKKIYSLALRRLNVDFHTSTVIYSFKRCIINQVTSKTYNREKKRSNCTVILKNGQIFGIENLIGLRQSDNTSSYLIGRYYVLKNKSLIRDRKLDHLIPLAEKLKIITAVESDMVVQKVMIIKLDDNHCVVYAHSCSSEMLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MNW1</accession>
    <name>A0A8J2MNW1_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HICCMSTLAB_LOCUS10119</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5101046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MNW1"/>
    <dbReference type="OrthoDB" id="7868124at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007999">
        <property type="entry name" value="DUF745"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37161:SF2">
        <property type="entry name" value="AT11648P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37161">
        <property type="entry name" value="HDC10475"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05335">
        <property type="entry name" value="DUF745"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035173754" evidence="3">
        <location>
            <begin position="32"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="32"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="402"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="50"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG5101046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="472" mass="52230" checksum="49DAB881D0959819" modified="2022-05-25" version="1">MRKRRRWRNIQYFLALYLVALTFGNLKRAKGAEAQQNGTTNRARGLKSIGNNNNGNNHYNPHYLDEKLRKVRDVDEMRLKRIEKRDQLEKSSEIVNKAVEEAKAASEAQGMAAQQAAHQVKSQLADRAIRAAKAAEAALSGKIALLEQLGEETKEAQIVFQDGSLELEQIRKSTNAAIRVARDSRQQLQMLTKAVNMVKTSMRNADVSVVGAKRSLTSKQKLLGAAKKRVEDLVERLHVAEDDLIKIRSVAIKAQEFARNARSKVNRIAANSARELREAGENKATNIAQDAANEAKAASDIQNAAAAEASRQIKAQLADKASSAAKTAEAILIGKMSVVTQLQQEVKEAQSVVDEEVGSIRRAKDLVKSAVLAAQQIGEEYKTLSRSLSTLTKNVEVSEEASQGARRELIEQEQLVNDARRRLHELTKRTRQAKRDLENTKIAVMKANAAARLAQENAARIKSRFASFDKSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MP85</accession>
    <name>A0A8J2MP85_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CABIT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HICCMSTLAB_LOCUS4328</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5085275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MP85"/>
    <dbReference type="OrthoDB" id="6077228at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025946">
        <property type="entry name" value="CABIT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052281">
        <property type="entry name" value="GAREM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14454">
        <property type="entry name" value="GRB2-ASSOCIATED AND REGULATOR OF MAPK PROTEIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14454:SF11">
        <property type="entry name" value="SERRANO, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12736">
        <property type="entry name" value="CABIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CABIT" evidence="3">
        <location>
            <begin position="57"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="428"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="504"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="554"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="556"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="638"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG5085275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="638" mass="69766" checksum="3ED1F83AF095EA0A" modified="2022-05-25" version="1" fragment="single">WGLEDASQETGALNPLLKPPFEPSWGMAATDGQIVVAAARWAEEATYLREFVSKHRLPAVIKITKGQYAGLGVPTLPAPSLQSTALLVSAGRRRKIVAQAVKIKEGRRVVGVGPRLAIPDSYHGYFEILSEEGRAVRGIESVAELARRCPEEGALVRETLRAIVCKLDEASNVVPEGTRSLLAGETILTAGEINLPGRGRFLRCLDSHGDSLLLSMDQRGRFSALAREDNISGVHTARALLSKRLPLTVRLVYGQPPRGLKSASQFLPELRLLSTFEEEHIFALPLQREGAAVSLPLAAPLKLVKARNEEALRSMAEFARLVDRSGRLVADVADRACVLDARLTENKQTRQTRSAAAFLRRSVSSDSANNHRHLHYHQNGNLNLSLNLNLGPGSSYRDENRVYTEDYDEIDQIYDYVRGFAPLPKSVRSPYETPGKELSASPPLSPVVLDERPEPPPIETIPTKKIQAEKRTRKGKDTPSQVVGQRQPLPKLEKPPLAKLYVKNGGTQRGRALMRQKSASPLKETPPGFKGGSPLFNIRYKSLTNLQQAMELDGTLDSSHSGGRTSGDSGAGAKLPEKRSRRLSRPRSLTNLVWELRGSTVARPETPPPVQPSIPAAKCGARLAVTVVAPRRVGTLYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MPC4</accession>
    <name>A0A8J2MPC4_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Similar to DHRS7: Dehydrogenase/reductase SDR family member 7 (Homo sapiens)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HICCMSTLAB_LOCUS10586</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5101684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MPC4"/>
    <dbReference type="OrthoDB" id="47007at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053011">
        <property type="entry name" value="SDR_family_member_7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44269">
        <property type="entry name" value="DEHYDROGENASE/REDUCTASE SDR FAMILY MEMBER 7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44269:SF1">
        <property type="entry name" value="DEHYDROGENASE_REDUCTASE SDR FAMILY MEMBER 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="5"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG5101684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="327" mass="37026" checksum="0C2E4594779DCA51" modified="2022-05-25" version="1">MWCELVGAITIIYYLFYLIFPWFIDCDVQLYLKEKFGQPIYVLRGKVVWITGSSSGIGEHLAYELAKVNCKLILSARREEELIRVKQQCLKINPSLQDSDVEVFKFDVCDYDSHEKSLGYIIKKFGELDILVNNAGRSQRATWEKIDIKVDKDLFDLNVFSAINLSRLAYRYFAEVGSGHLVVTSSLAGILGVPFSGSYTGSKHALHGYFESLRGEKMNLNIPITMVCPGAISTPFLPHSFTETHGEEFGEKTDVNASNKLTPERCGYLMAVAIANRLNECWISKAGALQITYLIRYYPNLAEVILTKLGPKFFQRLRDNKVTVDTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MQ44</accession>
    <name>A0A8J2MQ44_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HICCMSTLAB_LOCUS5067</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasmic vesicle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5089013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MQ44"/>
    <dbReference type="OrthoDB" id="18718at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032007">
        <property type="term" value="P:negative regulation of TOR signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.680">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039842">
        <property type="entry name" value="TBC1D7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043039">
        <property type="entry name" value="TBC1D7_dom2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13530">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13530:SF3">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="3" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAG5089013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="133" mass="16036" checksum="DE33A873F3BC6AA4" modified="2022-05-25" version="1">MQRKKEFHDLEKALRVTKIVDENSKSHQTLLIMWLLRKRRAKLDINSQLESSLFRAMSRMAESLWHIMDGDQEYEKKIDIYWLLSGFLDHVDKFYNDVGRLIECTLALLEKEDSDLYEHLLQFEVFNNIPFDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MR11</accession>
    <name>A0A8J2MR11_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS5490</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5090107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MR11"/>
    <dbReference type="OrthoDB" id="5812619at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="132"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="186"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="206"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="223"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="252"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5090107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="435" mass="51369" checksum="E04C42E7CF5887AA" modified="2022-05-25" version="1">MQIDNSNSDECSNGNTVETNETLKKKKHKRRRESTENDLIKNQISQEDTNDKVKKKKKRKHDIERSEDNELAKESTDEFISTNMSIKMESLSDDESVGLAKTEKKKKKKKYKKSNEQEQRDENIDSSSGNIKFEKQELTEHVDKLKKKKKKLESDSTVNSSKENVKKRSKKEKKSSDESGEIVTEETVKEFKNPKKIELNNKSDNESNSDNKMNSYNSNSSEESLREEELKSNTITKKIEKQRIQVEQNISDSDEEDDEDYDEEETLPRKRRHKSIFEQHPKLAKIMTESDDEQDELQYQQLNIREAKQLSDLVVKLIHHVLPQHNIEKYAGTRPLSKEEKERFKKYAPSKIGVFSPDEDSRIVHNWKKFCKEHDWKISLVYPFTFWKRKGFYFISKVEERRKFVQFLAHGLPDRSLCSIFGRFKILYGTHKKSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MS63</accession>
    <name>A0A8J2MS63_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS8936</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5097905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MS63"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035239086" description="Ig-like domain-containing protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="2">
        <location>
            <begin position="78"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5097905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="272" mass="31304" checksum="5CE1D757A9E31136" modified="2022-05-25" version="1" fragment="single">NFGALFLLVHIYAAESWANPPSLFPNIKEITLSENDTLELECTSQKNVTFIYSSDTSCTYYMFQPAQRYQYECFSNKPNITYEFDGEKYLAKFSREGTIFQETGWYGCIESDKLIAEGWDGLEWIGLTPDYFNKSDVSWTYNASIAYSYSDAWNDQISHTLTNDIIISGVTSEDEGVYECEYVAPQLKKRVSSKINITLDNGIIALDDSIERLEKMKHKSSNIKVEMKSLFNDYHIHQSRVEKIVTDKSSARKFAGTRFSLIEEIPFKQLIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MS86</accession>
    <name>A0A8J2MS86_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Similar to Orct: Organic cation transporter protein (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HICCMSTLAB_LOCUS12582</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5107093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MS86"/>
    <dbReference type="OrthoDB" id="2544694at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24064">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 22 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="28"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="58"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="142"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="193"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="315"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="423"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="454"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="483"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="505"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="540"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="566"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="685"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="709"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="736"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="768"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="882"/>
            <end position="899"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="911"/>
            <end position="930"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAG5107093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="965" mass="109258" checksum="33F9A8A0E86DA5E6" modified="2022-05-25" version="1">MYYSFFICLMACFYLVFNVDNFKVNRYVFMITMVIIELVSLFSVSIILKFLSSQKTTIILYWIASICLLSTIAIPKENVYMTVGLTVIISKLTLSPTFTTNMLFSLKLFPSSVRNSALGTCLLMSQAGSMSAPYLVDFLGKVAPWSPSVLCGVTLLIAGLLCCIVPTMENEKNKIQEKYLLQAIDELGKGSKLVWIAFFLSVTNSIVIALHTMSYIFLVEIPEHWCHIPELLDANWTNEQIQNISAVDRCLMYDYNYTHLAHLGYENAGKHVEDFLFNTSLVPCSSFVFDKSEKSTIVNEWSLICDRQFYRASTYLIYTFGKLLGLGGLGVFADKYGRKKALIIDESPRWLISQNRLDEAQKIIEKYRKVSISPGLLTESLPLKSLSIKQSIAAEEKRQESCMKRYLGNIGIFLADPIFRKKILIMYFSFFVCLMTSFYLVFSVDNFKVNRYVFMIAIVIIQITSLLLISVIIRFMSSQKTTIILYWIASVCLVSMIAVPNDNVYIILGLTIISKFCLSSTFTTNVLFSLKLFPSSVRNSALGSCLLMAQVGSMSAPYLVDFFGKIAPWSPSLLCGGALFIAGLLCCIVPIPGHWCYIPELLDANWTSEQIQNILAVDKCLKYDYNYAYLGHLGYENAVKHVEDSKFNTSLVPCSSFVFDKSGKSTIVNEWSLICDRKLYRANTYFVYSLGKLLGTGVLGVFADKYGRLKAIIIGLVLQMIAVPLTSIVPWFSGYILCELLIGLSVSTIYSSGYTIMSEIASEKKMKMLGTIVDINWSVGTCLLIVICFYVTDWRNLQIILSFIDESPRWLISQSRHDEAQKILEKYCEVAITPALITASIPLTSIPMEPSVTKEKYQPSCMERYLGNIGILFADPTYRKKILIMYFSFFVCVMVSFYLVLNIDNFEINRYVFITASAITETLSLLLVLSENDYYSLLDRIDLYAVNDYYSQRQCIFNFRTDGDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MTL0</accession>
    <name>A0A8J2MTL0_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Caspase_1_like_Cc</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HICCMSTLAB_LOCUS13628</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the peptidase C14A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5108992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MTL0"/>
    <dbReference type="OrthoDB" id="6116485at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043525">
        <property type="term" value="P:positive regulation of neuron apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00032">
        <property type="entry name" value="CASc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029030">
        <property type="entry name" value="Caspase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033139">
        <property type="entry name" value="Caspase_cys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016129">
        <property type="entry name" value="Caspase_his_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002398">
        <property type="entry name" value="Pept_C14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011600">
        <property type="entry name" value="Pept_C14_caspase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002138">
        <property type="entry name" value="Pept_C14_p10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001309">
        <property type="entry name" value="Pept_C14_p20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015917">
        <property type="entry name" value="Pept_C14A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10454">
        <property type="entry name" value="CASPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10454:SF245">
        <property type="entry name" value="CASPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00656">
        <property type="entry name" value="Peptidase_C14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00376">
        <property type="entry name" value="IL1BCENZYME"/>
    </dbReference>
    <dbReference type="SMART" id="SM00115">
        <property type="entry name" value="CASc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52129">
        <property type="entry name" value="Caspase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01122">
        <property type="entry name" value="CASPASE_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01121">
        <property type="entry name" value="CASPASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50207">
        <property type="entry name" value="CASPASE_P10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50208">
        <property type="entry name" value="CASPASE_P20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="5" id="KW-0865">Zymogen</keyword>
    <feature type="domain" description="Caspase family p20" evidence="8">
        <location>
            <begin position="52"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="domain" description="Caspase family p10" evidence="7">
        <location>
            <begin position="197"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAG5108992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="297" mass="34651" checksum="907DE85AB709B2FA" modified="2022-05-25" version="1">MNDFQFNELKSIIENELDSDKKWNKVTDKNNHQDDGGYKREIVTHYEMDKTKRNYAVILNHEIYDKTFLEPSCKREGTNVDCKNLIDTLEFLSFEVDEFSNLTYSQIVQRLRKVADMDHTQHNCLLIVVMTHGDLGILYAYDTMYYARDIWSFFTPEKCPSLVGKPKLFFMQACQGKLLDDGSILSEQTVTDGSSFNFNSLITDADFLVFYASVADHRSFRNEQQGSWFIQTVCRQLRERATKEDILTVLTYVIQHVALDFVSRAPEKPLIHEKKQTPCIISRLTKLLQFYPKNESD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MTN9</accession>
    <name>A0A8J2MTN9_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Similar to KNTC1: Kinetochore-associated protein 1 (Homo sapiens)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HICCMSTLAB_LOCUS12796</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5107543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="343783at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005828">
        <property type="term" value="C:kinetochore microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990423">
        <property type="term" value="C:RZZ complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000070">
        <property type="term" value="P:mitotic sister chromatid segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007094">
        <property type="term" value="P:mitotic spindle assembly checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903394">
        <property type="term" value="P:protein localization to kinetochore involved in kinetochore assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055403">
        <property type="entry name" value="ARM_KNTC1_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055404">
        <property type="entry name" value="ARM_KNTC1_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055405">
        <property type="entry name" value="ARM_KNTC1_3rd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052802">
        <property type="entry name" value="KNTC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055402">
        <property type="entry name" value="KNTC1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019527">
        <property type="entry name" value="RZZ-complex_KNTC1/ROD_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15688">
        <property type="entry name" value="KINETOCHORE-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15688:SF1">
        <property type="entry name" value="KINETOCHORE-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24520">
        <property type="entry name" value="ARM_KNTC1_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24516">
        <property type="entry name" value="ARM_KNTC1_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24515">
        <property type="entry name" value="ARM_KNTC1_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24506">
        <property type="entry name" value="KNTC1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10493">
        <property type="entry name" value="Rod_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="KNTC1 N-terminal" evidence="3">
        <location>
            <begin position="17"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="KNTC1 first ARM-repeats" evidence="6">
        <location>
            <begin position="368"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="domain" description="KNTC1 second ARM-repeats" evidence="5">
        <location>
            <begin position="720"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="domain" description="KNTC1 third ARM-repeats" evidence="4">
        <location>
            <begin position="1225"/>
            <end position="1443"/>
        </location>
    </feature>
    <feature type="domain" description="RZZ complex subunit KNTC1/ROD C-terminal" evidence="2">
        <location>
            <begin position="1487"/>
            <end position="2035"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1388"/>
            <end position="1415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24506"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF24515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF24516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF24520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAG5107543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="2057" mass="236950" checksum="B18D67F5FC386121" modified="2022-05-25" version="1">MWTKISSGFDADEETANFGTRNFAETPGSIYETWTLAVIQPDVEVVENPKVTATVFDTRLCVSVDNSITIFNDLSCNDVLSSIGFDSQVTSYCLSKDSSLLFVSVEPAELHCFTLTDSGQEIFYLDLHQHFQCHRIIKVCLDEQNDLVNLFIVTSVGKIYQINDFNKAVSPNADDDNIIKAIQVLPIHNSKIEYADLKQSSKISVKTLVTLGDDIYLFPANISCPLKSLPYQYIKAQFFKNYSGMICLRADKSLSIVHLNTLIGKKVWDGPVADFVTLQEASDSNHMLVLMDSEPSADTTSLHLMSFPDFKIIFTMTVPRTTYLIDVVGGELIDNLMIIEGMKNSSDLVGAIRVKSIGESLPEYRLQRLLKQQRFDEAREFASKFKLNCECIFQAQLSVLMNQLRPQLDDNETVDLDSFISILDQIKDVKYIYECCSKALTRDYQDTKRLYMYTKKRIFDCINLSSTASITEDHSRLLHEVSDTLKKLETFECIQKVRSEYRSDDFTDINEWDKFSRANLLEECIRYLSLGEVHAAALIWTRHISSIAPRVGRGTVEQILEVIPGNLGPTDLWPWLHQFIPSVTSFIPSSLTEIILWGYKKTKSLEKSHRDQWPAIGLQFLEGLVDLLHFEEYKVCFQLHQQYTNKNSQFHRLMKLMQAVSDLVDLKTHYKVLLPLNTYLSNPIDVVTLLLNKIHIDEIPGLMSNFLNQYMVNHSLKNDEVLSTYIQNTLKNSKQWWIGDKAPWDKRLTVVISYIHNIQNRLQQTLEVLKKAPVPWSDALSTLADQSYKYNHPLVAQIHIESNSITLKLILKKYGFAHIGCNINLYKNIIKQDRADMVEDLFELTKADNNLRQEVIFTCLNYQLCHGNTERFMDTIDKLDGDLLLNCCQQIVDMIKIKLSYNKLDTSLEYYMEVQNTLENKLKEALTSAKNKKYAELNDSHQTLKLLKNIYRLFKEFDIDVDQNKYCLHKKDIIHSYIVKIVSMCEDDTDWLIICKRVERVSGLLGLPKFFGLHEVLQQISPPQKLKDYIIDRLNSAGMSPDPDESRYIIKICSELLLNLDDNSQLAICLKNSCSSTLIHSTEKIESLTENLLLINRIEAYNEAVGAEKMETGLQSPLSFKLYPIYTDASFSPGNILLPLLKDALDICRHYKNISRGKEKALEVDPEVIRYIIKNLFHKVKAVQSEHHDYALLKIFMIIQTELCSYQPVSEEAVKEIKVVMKHCSCMLLKKLVSNRSFDIHLGLACLFLQDKSEVIKILASISKYFQTDPSRDRVIKDLGYEYCRLIKNDSHIDLFNEQRIIHCWAERLGQYGISHQEVLQSNIEGKRNIMIRIMKSKKPEALKVLEDFCCNFGFSLKDCYLKLLETLLLSWQPNYSLTTGKDGKKDLKVDETDIKELENVCKKLIKKIKNVKDSKHSEIKTHLETLKQRVNFYHYEIFLLLLNLGNEKDFELQSYLRFLKNYIRISPPTDIEREEWLNYCQDEHSLPAIAQWRLPYLPKVSIFKLITQELNLKTYEEWLKIAPVLKIANYCICTLAVKGAVAEAWPHNSVTSNNRASSHSHNEWSIHLRNGALLQEIKKCINVCIKQKEEIQYGAAAWYHVVNYTPPGADRVAAAKECFLYAQNWQQQVDDPLAPDDSIKSKLYKIEEKYFKYTSKHTLYTYGLGQDRYLNLVENPEKLVQELYHDETIPARYKGVIKNRPDINAAVTKLGDIFKLNLMKIRLALLHEWLQPEVGDNKANDTLNMFNDFSTLSNSITGDTFTTDDNLLRACYLVGSDNSENYANYLLNISLIEGNDEDYGNLYEPGMRFRALRVLQSIKDEVALADYAKRDPQRVNQYMKSLQYLTELERFGLSYSITNFDMCSKQKLVQILVNSQYSTPRALGLIPQLYLDYDIEDLSYLNTALEYMVKYSLVQELKKNLLKLGSIDRIINFPGYIAAWQLIINEPFNKLDHSSKSIDNCIEALRLLHVCPIIDKLQFSSNINYCFVAKQPHFAASLLPFLNGNEQEIVLQKLLQNLNYEEITSKMLDLASKGVSIVYQSITMLNQARTKISIEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MUN9</accession>
    <name>A0A8J2MUN9_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Amino acid transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HICCMSTLAB_LOCUS9877</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Membrane</location>
            <topology evidence="1 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5100804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MUN9"/>
    <dbReference type="OrthoDB" id="5877963at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015501">
        <property type="term" value="F:glutamate:sodium symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005313">
        <property type="term" value="F:L-glutamate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015175">
        <property type="term" value="F:neutral L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3860.10">
        <property type="entry name" value="Sodium:dicarboxylate symporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050746">
        <property type="entry name" value="DAACS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001991">
        <property type="entry name" value="Na-dicarboxylate_symporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018107">
        <property type="entry name" value="Na-dicarboxylate_symporter_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036458">
        <property type="entry name" value="Na:dicarbo_symporter_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11958:SF63">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11958">
        <property type="entry name" value="SODIUM/DICARBOXYLATE SYMPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00375">
        <property type="entry name" value="SDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00173">
        <property type="entry name" value="EDTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118215">
        <property type="entry name" value="Proton glutamate symport protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00714">
        <property type="entry name" value="NA_DICARBOXYL_SYMP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0769">Symport</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="70"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="112"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="148"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="244"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="275"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="322"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="34"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="41"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAG5100804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="527" mass="56790" checksum="037F921148AAFEBB" modified="2022-05-25" version="1">MNDSFAHTNSYRPAPELVVCCSRIIILRSPLSGADAQSKPLDTERRSCYRESPNKRPLNRRQRITTCLRHNALTILTISGVVGGIAMGLILRNARSGWTEREIMYVNYVGELFLRMLKSLILPLIIASLVSAIGSLDLSLSGKIGARAITYYMITTVSAVILGIILVITIQPGKYGKSDNSSEDNGVGPRNVSTVDTLMDLVRNMFPPNLVQACISQYRTVLTRQPNNPSGDINTWKIGSEDSSGMNILGLVVFATVLGITLGKMGPDGKPLLNFFEALSSAMMIITNWVIWLSPVGVLFLVSSKVLEMKSFDVILGQLGMYFLTVIVGLVIHGFIVLPTIFFIITRKNPIRYISNMAQAVATAFGTSSSSATLPVAIGCLEERNGIDPRVSRFVMPIGATINMDGTALYEAVAAIFIAQVREISLTFGQLAAISITATAASIGAAGIPQAGLVTMVMVLDTVGLPAKDVTLIIAIDWLLDRFRTSVNVIGDSLGAGIVNFLSRDELEALPHHVQAKNGADNNTTSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MUV0</accession>
    <name>A0A8J2MUV0_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RNA polymerase II-associated factor 1 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HICCMSTLAB_LOCUS13630</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PAF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5108994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MUV0"/>
    <dbReference type="OrthoDB" id="10260285at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016593">
        <property type="term" value="C:Cdc73/Paf1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000993">
        <property type="term" value="F:RNA polymerase II complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007133">
        <property type="entry name" value="RNA_pol_II-assoc_Paf1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23188">
        <property type="entry name" value="RNA POLYMERASE II-ASSOCIATED FACTOR 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23188:SF12">
        <property type="entry name" value="RNA POLYMERASE II-ASSOCIATED FACTOR 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03985">
        <property type="entry name" value="Paf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="360"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="384"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="467"/>
            <end position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAG5108994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="476" mass="54942" checksum="80CCC3E4075E5415" modified="2022-05-25" version="1">MLPTETASPMDTSISPFPETTKTPLMYECKHSDILCRMQYSNKLPDIPFDLKFLIIPFKSTRFSEYTPSSLERNHKHEFLTDYDMGVDVDLVDIEKYASTETETSLHPDDEKLLEDDCFTLPVSKRSKMYSTKVVWLRSTEYISPGNTRLQPQVFEKIEAQVGGKGIKKLIAEGIHYLDHDQQLKAIDKTFADNKIPIEKHHNKPNVYPVEVLPVFPDFQLWKHPCAQVIFDIDPSPAGYSQPQQLQLMSQAMLRGVMDENEEQFVAYFLPSDETLEKRKKDIEAGVDYQDDESYEYKMFREYNWNVKSKSTEGYEENYFMVLRDDGLYYNELETKVRLSKRTKGGGLMNRTKLIVKHRPLNGHELNVQKSRTNHFKSLVTDNNEGDEGIDVSDEEEEEEEEEEKEGAGQNGEENSFGSRNLRSRSRSLSSNRSTDVNSQDESHRSIKSEQNSHSIEIIADRNAECTDQDTEAESD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MUY7</accession>
    <name>A0A8J2MUY7_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS8458</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5096933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MUY7"/>
    <dbReference type="OrthoDB" id="7653744at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5096933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="299" mass="34269" checksum="A0753DC6908AAD3F" modified="2022-05-25" version="1">MIDKRQVVMLLYDALNSVRYPGIAQVDVQNFKSCFFSENNIFSLLRWLYMKGIDKINPTDKTLNFTQGNKDSAADPLAVDEKFLIKWYSQSGIYTSEKAIQGQCQIDAFNNLTDYIINVICSNTKFLPALIAWNGVEKYFANQISFTPLSYNPKKSIQVGHFKSYIENMKKCDKTENNVDKESMKKELASFTYENESNSAIENQKKKNQPFVFKKFCKNFQNDDIGPKIVVENKKSHDTSVVRNTVTKFSSLSKVICAKTELRCSLDSAYVKIENSFFHSVSENIMTQLNNLTKARDAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MWE0</accession>
    <name>A0A8J2MWE0_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS9745</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5100672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MWE0"/>
    <dbReference type="OrthoDB" id="8192078at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="31"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5100672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="628" mass="71626" checksum="D6BA610D54B9F44C" modified="2022-05-25" version="1">MPTCSICSIQVDCINTLIFHIAKYPDIKNIYNCGELNCYSTFSTKDSFKKHLQRIHDCQLNSLVVKDININLTNETRKFSNSENLNYDSNTQSNFQQNTNNPGFSANDFKTALNKAALSEDMQEAPTIVNLDDDIISPVKQSGIDNYLSKPKILHTKILDETEMIDTSKSKVGSFSSVLSEAKKLGFNSSSSSDKSDLKVDKDAKVFLSDSFIGILESKVENTLINSNCSDKDINVFKKMFDDIKNTFADLDTEHRRLKHFEKSGSYIKPKSYIIDRTYVISKSKKGSKGKMIDICGQFIPLRATLKNFFQQPNALTDTVNYMEQLNNNETVIENYIQCKSWAKKRSEYKDDDIVIPYFLSGDDVEVNNSLGSRSGKVMPIYASIPCLPSECRSKLENYFLVLLYDSWIHLNKNKKNRTFRIYRPLIKEIKFLEEKGIKILTNQGEKHVYFVLGLIQGDNLGLHGLLDFTESFSATYYCRFCKMDKNTCQNTIFLSPELTQTVQNYKTDLKTNNITLTGIREKCVFNSASFHAVENFSVDEMHDFREGIAHDDLIEILSAITLQNSEYYEFSVSELNERLAVFDYGPIDSLNKPPFIRVDDLSKNNKLKMTASELTMFVRLLGVIIGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MWH2</accession>
    <name>A0A8J2MWH2_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Similar to CAP1: Adenylyl cyclase-associated protein 1 (Homo sapiens)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HICCMSTLAB_LOCUS10479</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CAP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5101577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MWH2"/>
    <dbReference type="OrthoDB" id="1601at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008179">
        <property type="term" value="F:adenylate cyclase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019933">
        <property type="term" value="P:cAMP-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000902">
        <property type="term" value="P:cell morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.330:FF:000001">
        <property type="entry name" value="Adenylyl cyclase-associated protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.330">
        <property type="entry name" value="Adenylate cyclase-associated CAP, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001837">
        <property type="entry name" value="Adenylate_cyclase-assoc_CAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013912">
        <property type="entry name" value="Adenylate_cyclase-assoc_CAP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017901">
        <property type="entry name" value="C-CAP_CF_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016098">
        <property type="entry name" value="CAP/MinC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036223">
        <property type="entry name" value="CAP_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053950">
        <property type="entry name" value="CAP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036222">
        <property type="entry name" value="CAP_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006599">
        <property type="entry name" value="CARP_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003124">
        <property type="entry name" value="WH2_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10652">
        <property type="entry name" value="ADENYLYL CYCLASE-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10652:SF0">
        <property type="entry name" value="ADENYLYL CYCLASE-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08603">
        <property type="entry name" value="CAP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21938">
        <property type="entry name" value="CAP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00673">
        <property type="entry name" value="CARP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69340">
        <property type="entry name" value="C-terminal domain of adenylylcyclase associated protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101278">
        <property type="entry name" value="N-terminal domain of adenylylcyclase associated protein, CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51329">
        <property type="entry name" value="C_CAP_COFACTOR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51082">
        <property type="entry name" value="WH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WH2" evidence="3">
        <location>
            <begin position="541"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="domain" description="C-CAP/cofactor C-like" evidence="4">
        <location>
            <begin position="602"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="118"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="506"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="139"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="161"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="512"/>
            <end position="528"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAG5101577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="705" mass="77894" checksum="1A79981AB222C08B" modified="2022-05-25" version="1">MITVVEENLLVVNREIEENLSKIRKHSKDRSDVELSLGCEEENLNFTLVKCEEDKEDKSVLVDNNNKEEEIDVDLDESKEETGGSCSIKNEEIISISSIEGEENLNFTLIKCEEDNSKLASSKSEQDNLIVESNEIETEDKSKNDKQDEEAKGVEGGGGDGNEEDNEESDSTSTTISIKTIDDIKTCKLTLDNIVMGPPTVCLYQAPGYIERTIADGPDDEGDDSVFENSITTEPGGYENERDEHLEQLVTRLENVTKRLESVPSKFFTETQEVAIQTYFSLPKQVESVDVSTGHEFEEEDQEFPDPPDFGEVEVEVDQNSEVDYTVSMSVGGYEDLVAGPFAEYLALSQKIGGDVAAHSKLVSEAFRIQKEFIKTAASRPAPSNQSEQVSLLGPTSSQIQLIQQFRENNRGSQYFNHLSAISESIPALGWVAVTPTPAPYVKEMNDAGQFYTNRVLKDWKEKDKNHVEWCKAWVQTLSELQKYIRQHHTTGLVWSKAGSVSSSASAAAAAAPPPPPPGGMPPPPPCMPVGDISASAGGDDRSALFAQINQGEDITKSLKKVTSDMQTHKNSSLRTGPAPFKAPVYNNSSSPMKSVPPANAPIDKPSVFSRDGKKWLVEYHKGNKDLVIENPEMNNVVYMYRCQDSTLIIKGKLNSIVMDSCRKSSIVFDSLVSSIEFVNCQSVQMQLKLLKNTNENDLENPVNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MXF1</accession>
    <name>A0A8J2MXF1_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Fatty acyl-CoA reductase</fullName>
            <ecNumber evidence="10">1.2.1.84</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">HICCMSTLAB_LOCUS11465</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the reduction of fatty acyl-CoA to fatty alcohols.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>a long-chain fatty acyl-CoA + 2 NADPH + 2 H(+) = a long-chain primary fatty alcohol + 2 NADP(+) + CoA</text>
            <dbReference type="Rhea" id="RHEA:52716"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:77396"/>
            <dbReference type="ChEBI" id="CHEBI:83139"/>
            <dbReference type="EC" id="1.2.1.84"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the fatty acyl-CoA reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.84" evidence="10"/>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5103349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MXF1"/>
    <dbReference type="OrthoDB" id="429813at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102965">
        <property type="term" value="F:alcohol-forming long-chain fatty acyl-CoA reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080019">
        <property type="term" value="F:alcohol-forming very long-chain fatty acyl-CoA reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035336">
        <property type="term" value="P:long-chain fatty-acyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05236">
        <property type="entry name" value="FAR-N_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09071">
        <property type="entry name" value="FAR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000143">
        <property type="entry name" value="Fatty acyl-CoA reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026055">
        <property type="entry name" value="FAR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033640">
        <property type="entry name" value="FAR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013120">
        <property type="entry name" value="FAR_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11011:SF107">
        <property type="entry name" value="FATTY ACYL-COA REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11011">
        <property type="entry name" value="MALE STERILITY PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07993">
        <property type="entry name" value="NAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03015">
        <property type="entry name" value="Sterile"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="7 10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 10" id="KW-0521">NADP</keyword>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="28"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="domain" description="Thioester reductase (TE)" evidence="13">
        <location>
            <begin position="37"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="Fatty acyl-CoA reductase C-terminal" evidence="12">
        <location>
            <begin position="356"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00052530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF03015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF07993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CAG5103349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="485" mass="54888" checksum="FDB4AC4A0A2F3959" modified="2022-05-25" version="1">MGTSNTQTENDHKHNNEEANPGGTSIEAFFAASVILITGATGFLGKALLEKLLRSCPRISTIYVFDRIRRECPSAFSKIIPVMGDVSQPDLGLSEQDRLMLTQKVNIVFHGAATVRFNEPLKVAMTLNTRGTERVVELCTGMINLISFIHVSTAYSNPEQAEVDEIIYSTKIMPEIAIDMCENLDDETLAILEEKLKGRHPNTYTLTKRLAELIILKRGTSLPVAIVRPSIVCAAYREPYPGWIDNTSGLTGLIVQISRGTLKSVYCKKNLKVDIIPVDFVVDTLVCAAWHNVMRRTNTIKIYNCVSGARNPITWGKFGYYLNKYAVESPTKLAVWYPGFNYTPSLLFHKISTVLFHHVPAFIIDIVLKFRGEKPMMLKLSKRFARIASTGYYFANNEWNFLSDNVNQLSECVKTVTDSSNFNVDIKTLDWSTYVHGYILGIRKYILKDELETLTQARNRLSKLYWFQRSMQALMALLLIKLILR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-10-16" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>S6CVM0</accession>
    <name>S6CVM0_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cc_single_20.4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">CcBV_20.4</name>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS6093</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Philos. Trans. R. Soc. Lond., B, Biol. Sci." volume="368" first="20130047" last="20130047">
            <title>Functional endogenous viral elements in the genome of the parasitoid wasp Cotesia congregata: insights into the evolutionary dynamics of bracoviruses.</title>
            <authorList>
                <person name="Bezier A."/>
                <person name="Louis F."/>
                <person name="Jancek S."/>
                <person name="Periquet G."/>
                <person name="Theze J."/>
                <person name="Gyapay G."/>
                <person name="Musset K."/>
                <person name="Lesobre J."/>
                <person name="Lenoble P."/>
                <person name="Dupuy C."/>
                <person name="Gundersen-Rindal D."/>
                <person name="Herniou E.A.Drezen.J.M."/>
            </authorList>
            <dbReference type="PubMed" id="23938757"/>
            <dbReference type="DOI" id="10.1098/rstb.2013.0047"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5092374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="HF586473">
        <property type="protein sequence ID" value="CCQ71116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S6CVM0"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5092374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCQ71116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="101" mass="11326" checksum="DC74B7C26A44B82D" modified="2013-10-16" version="1">MMDVSQLPPLSNDGSLVKNFIAQLRAYRPPSPTISESDRTPAERYVDRWLSNSKQSTAVSGSENERSTSQQENQISSKADTTYKDHGFVARWAAEHLKPET</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2E0D2</accession>
    <name>A0A8J2E0D2_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Similar to ITFG1: T-cell immunomodulatory protein (Macaca fascicularis)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS124</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030000720">
        <property type="protein sequence ID" value="CAG5071975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2E0D2"/>
    <dbReference type="OrthoDB" id="10250728at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5071975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="72" mass="8495" checksum="01B0163375FC64D7" modified="2022-05-25" version="1">MGVFYDFYQDGILDVILVEHDKATEQYHTRTFKNSLDCDTTFVRVMILTGFTNSKYPISNGICWEKEADLWY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2E4C0</accession>
    <name>A0A8J2E4C0_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS81</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030000563">
        <property type="protein sequence ID" value="CAG5071746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2E4C0"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5071746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="119" mass="13733" checksum="A2443BDA8EBC49F7" modified="2022-05-25" version="1">MNFDLPTKKNKLQNVQEETQKYVILKKKDSDKPPFLVPINSLAIETQNFLLESIKNHKPITTKTTLQLSESSSQLNQKTISVTDTRKKLANIATTQEKKDKKKNWSKKKHQRPKLISST</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2E4D0</accession>
    <name>A0A8J2E4D0_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS96</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030000597">
        <property type="protein sequence ID" value="CAG5071886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2E4D0"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5071886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="64" mass="7486" checksum="482CD85117233B3C" modified="2022-05-25" version="1" fragment="single">MASFVDEENLEKEYYDPSNPIGHYTDPRKFMSALNNFPDTAEHFRFKINDSGFTTIKRICNPPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2E7G6</accession>
    <name>A0A8J2E7G6_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Similar to Nep2: Neprilysin-2 (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HICCMSTLAB_LOCUS1956</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase M13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001116">
        <property type="protein sequence ID" value="CAG5075975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2E7G6"/>
    <dbReference type="OrthoDB" id="2016263at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1380.10">
        <property type="entry name" value="Neutral endopeptidase , domain2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000718">
        <property type="entry name" value="Peptidase_M13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018497">
        <property type="entry name" value="Peptidase_M13_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042089">
        <property type="entry name" value="Peptidase_M13_dom_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008753">
        <property type="entry name" value="Peptidase_M13_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733:SF237">
        <property type="entry name" value="NEPRILYSIN-LIKE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733">
        <property type="entry name" value="ZINC METALLOPROTEASE FAMILY M13 NEPRILYSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01431">
        <property type="entry name" value="Peptidase_M13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05649">
        <property type="entry name" value="Peptidase_M13_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51885">
        <property type="entry name" value="NEPRILYSIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M13 N-terminal" evidence="10">
        <location>
            <begin position="136"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M13 N-terminal" evidence="10">
        <location>
            <begin position="595"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M13 C-terminal" evidence="9">
        <location>
            <begin position="828"/>
            <end position="989"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF05649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAG5075975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="1003" mass="115575" checksum="2240182DCE4EB183" modified="2022-05-25" version="1">MNFIETIALESYWPLIRIVKEWKASEFDWVDFMIEGQDIGMPVKFLDIQPEATPEDHSISMTYILNIAPDEFKKNISDPGDMLRISYTAYLMGAFTSLGNTLTNDQIEELVEFQRKISEERLISKILLRNIKPATKIQDLVFLVPPSFSDFLDLLANTPKNFQANYAAWKILQNAVPFLDKSFFQAESIYCSEKNCKDRTRKNACLNLVEEYLKPAVILAYAKAHFTSEVESLVVDIAARIKDQYIQVINQSAWEKSDADFVEFYKDLEINTTNFLQTMMNLEKFDVKHRFNNATSLGPTELVDPLRNFFFRNVRGTIYMPLSSLAEPSFNPRDPIYKNIGSMGGFIAFILTKNIVHLGRNLDGGKEIDNQVISCLRRQLIPLQNPAANQLLTDSGLLSMIKKMLTISDNKLFWINSMEAFCRKEPTATKVIENKYHDFEYHILKALTSVPQFWEDFSSNPCDNSYRFVCGSSNRLAPKLGIITFTNLITTRITDLIEEGTVSKGIRPFQLIDDVYKTCKSNAAIGEQVVKSLFHVFEQLGGWPLLQGSQWQTKDYMLTDVTLRSKLLGISVNPFLTIEPLIEPESGRVATEFFVSELTEKYPSVFWSKLLNSLYPISKEKLNLSNMTFFVSSFLSTVFELLDETDSRVLYNYAGWKVLQHAIPYLTKDYQDLRREYCKTQECGGSLRDKCLKVVLKYLQPAVDLLYAKRYFTEEADSLVSAMVENIKRQTKDLISKSSWMDQDTKKEHIDAIDNIPVIIGYAEKNSTDDEFVKYYEELEIDTSNFFQTLMNLEAFDSPRRFYSTNGLGPRNFINPLLATADFSAGKLYVPMNMLREPFFSVDYPMSVNYGFSGRAIAKALARGILHRREPRSQAMKDKVACFSKQVANYTSQLPFETNLLIDEYLGFKISYHAYQSWLSSISGGREPMIPELPYSDRQIFWMSSLQKDCKRPWNKYKTIEDKYFPFEFRKMIDLSNVPEFYDDFNCQSQPFLETHGPSCTLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2E7N3</accession>
    <name>A0A8J2E7N3_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C-type lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS2077</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001116">
        <property type="protein sequence ID" value="CAG5076096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2E7N3"/>
    <dbReference type="OrthoDB" id="8066719at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00037">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035178296" description="C-type lectin domain-containing protein" evidence="1">
        <location>
            <begin position="25"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="2">
        <location>
            <begin position="132"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5076096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="240" mass="27875" checksum="0C4E05ADFCF72122" modified="2022-05-25" version="1">MLHRIKLNIYLFYLLLILILIVEANKCFTVNNNDLVPQYELIKNSRSIKSVIVEKKLSLIECQKLAITRKALAFNFYKKNNKKLNCQLLECPEINSFSSLIRDNKFNYYSLYPRYLYPVNITVKCLPRVGVFIISEESKNYTDAKKTCEEVNGKLAHIISEERTEGLAKFITHNTPVFVGLSNRRSSKDRFWKNEFDEPLDCFDYRGWNKGEPSASRGCVGLIVTKSVISDKTPAWRIQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2E8I2</accession>
    <name>A0A8J2E8I2_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS293</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001114">
        <property type="protein sequence ID" value="CAG5073349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2E8I2"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5073349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="192" mass="22450" checksum="C9DD3F22E6387903" modified="2022-05-25" version="1">MNSFFVSVYHYLHDMYVENSKIMIVLGSKNNFYFSQTDIQNGSNEPRVISLSQCKQIFHFDERIECKAKIKIHNSYVVTAYSERDFCIALKTETQNEEYDFVTKSIQGVNTFLHISNCVIKFDVMFILTQEGSLIFYKFKNINHLIDIDLLTNQAMAIETGSEYSLVKLMMRNLIPYTLIICEKKDIILLTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2E9Y3</accession>
    <name>A0A8J2E9Y3_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similar to spop-b: Speckle-type POZ protein B (Xenopus laevis)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS230</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001108">
        <property type="protein sequence ID" value="CAG5073109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2E9Y3"/>
    <dbReference type="OrthoDB" id="7628309at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd14733">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24413">
        <property type="entry name" value="SPECKLE-TYPE POZ PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="130"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5073109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="293" mass="33708" checksum="5AD82BA6B3ED5AB7" modified="2022-05-25" version="1">MKRGYTSVNSSCTKYEWRISNLDLHLRASNTGLNSYLSSPPFSAVDADRVHTMMKKDHLLFDSVERTVLELSKKKLLENESKNIPNNSLTVGLELTIYESCNNSTEDFFVPSKRPMSEDYKTLYSSKIGSDVLINVDGQKFSAHKTILIARSVIFTSKFLMETDKEIKELELQDITPNNFEKLLEFIYTDEVRDLDIHAYDLLEAANKYLIQTLKDLCEESISRTLSETNVFKALRLADRLNSKSLLKCVMDFIYLNINDLIETQDYLKLENENPDLAFRLLKNSLILVGKDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2EA61</accession>
    <name>A0A8J2EA61_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS1214</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001116">
        <property type="protein sequence ID" value="CAG5075017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2EA61"/>
    <dbReference type="OrthoDB" id="7679028at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="243"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="283"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="475"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5075017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="503" mass="59446" checksum="32B77D9F32A4BBDF" modified="2022-05-25" version="1" fragment="single">FLPKDTQLYYPTHPLYILSADTTEQLENLLILLKSSPFWNMKSTFFVIGKANKFCRDSAVILEEMWKFELLSSFVVCSKTNNQTMLYTYNPYTNRATDSWVAVRNKENSKRRWTLYKKAFINDPKICKTLKFDKTQFMDRYPVKIITGIHGQIGSLRPVFRSLNMQVKVHPHDECCGHQTNAGFLILGDEDIAAGFYHIDVFNKDVNIIPVLYEFHYIIITQKRSFTYSFREVIAMLDYRTLFAIKSIISLIFIVIVVNNRYHVGSAFLDVFKLLLSMDMDTPFVRLSMMFLFFTATFFMFVFEPAIESQLFALLTRPQSYTIENLKDLHDHQYHVYFYKGIRKDFINERLWTTVEDMKYLHPLDKNNPDDCLELASKNNTVACVYTSHIILETALNKILHVSSKFVFIKNNFVWSRKDWALNDRVYERILNTVESGFNDKFDRDWERNVLKTIKAKNRINQLDDYDEITEANLYYAYIAFMICQIIGICTFIVERLIARFRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2EAI5</accession>
    <name>A0A8J2EAI5_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS1393</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001116">
        <property type="protein sequence ID" value="CAG5075239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2EAI5"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5075239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="126" mass="14229" checksum="401F0DD58413BB53" modified="2022-05-25" version="1">MKFGINLIFSKLDITKINSTQISTITQIVPLRVSVLKDIINIKYAYRKLIEACEDISNFYGAPVLITFISLVGKGLTSTYLGVLLFMNIELTPVPWYQTGIRLSWIMLLFIILTSKIATIAEQVKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2EAM0</accession>
    <name>A0A8J2EAM0_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS67</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030000505">
        <property type="protein sequence ID" value="CAG5071496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2EAM0"/>
    <dbReference type="OrthoDB" id="6777617at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5071496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="191" mass="21263" checksum="505F58A881156273" modified="2022-05-25" version="1">MLQPSIENTSDESDDNQNNDYFGIDQNIISGSIEVYDSERNNLTEPTTSYGESLVKQSSSSLSELSLEITRPTINDALQLLNQPPLLTRRQNDDTYLNNKITRVAYNLRKALGVQNAFNDTDTSTSLRLQILTLMPSSWSIDKIVEVMGATTYMARLARKLAADQGVLPIPEKKIGTILSYKLILFGITNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2EBB1</accession>
    <name>A0A8J2EBB1_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Venom protein 21</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS970</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001114">
        <property type="protein sequence ID" value="CAG5074223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2EBB1"/>
    <dbReference type="OrthoDB" id="8145837at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006616">
        <property type="entry name" value="DM9_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006149">
        <property type="entry name" value="EB_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39069">
        <property type="entry name" value="ECDYSONE-INDUCIBLE GENE E1, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39069:SF8">
        <property type="entry name" value="FI17111P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11901">
        <property type="entry name" value="DM9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01683">
        <property type="entry name" value="EB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035228650" evidence="1">
        <location>
            <begin position="20"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="domain" description="EB" evidence="2">
        <location>
            <begin position="173"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5074223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="412" mass="46122" checksum="833634EEDBE30149" modified="2022-05-25" version="1">MIVFLSLIILLGDIPGGSTDECLPNSSGIDQQCSPVIGNKCTKEDDCPIPNTICDQVCKCKGGMHPSEDKNFCETDVKRIGDSCKDDECNTIENAVCKQTNVKTKFFGNKIWDTESTCQCKLNHFLSNLKCVKYANDLRDRCEDNRECYKIIGSKKCNKTTNTCQCNEKIYYLADGKCHKKTKNLHESCSNPSGCKPKFSECLNNECQCGSKYNEYNNVCYGLLNATCSQPSDCLSTSYSCGSSGTCENVEHKNGDKVLSSKPKITLSWINFNNKTKIGDGVYAGADGPGDIHVCRGVYENLLIPGKLLKLFNAHNYQCHVSYLNTEPDLMEFEMLSGSSLRWKESSFTLDKAVYGGANEDNKPYLICRTKHTIYQDRIIVGKLEPPLYKTCVAPFGRTVYYYKKFDILVHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2EBJ0</accession>
    <name>A0A8J2EBJ0_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Similar to G3BP2: Ras GTPase-activating protein-binding protein 2 (Pongo abelii)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HICCMSTLAB_LOCUS1924</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Stress granule</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001116">
        <property type="protein sequence ID" value="CAG5075912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2EBJ0"/>
    <dbReference type="OrthoDB" id="9972865at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010494">
        <property type="term" value="C:cytoplasmic stress granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00780">
        <property type="entry name" value="NTF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.450.50:FF:000015">
        <property type="entry name" value="Ras GTPase-activating protein-binding protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002075">
        <property type="entry name" value="NTF2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018222">
        <property type="entry name" value="Nuclear_transport_factor_2_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039539">
        <property type="entry name" value="Ras_GTPase_bind_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10693:SF20">
        <property type="entry name" value="AT27578P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10693">
        <property type="entry name" value="RAS GTPASE-ACTIVATING PROTEIN-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02136">
        <property type="entry name" value="NTF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50177">
        <property type="entry name" value="NTF2_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="NTF2" evidence="6">
        <location>
            <begin position="16"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="410"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="146"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="256"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="323"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="375"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="486"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="156"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="195"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="283"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="375"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="395"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="511"/>
            <end position="530"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAG5075912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="554" mass="61930" checksum="BB62FDE992FB8F69" modified="2022-05-25" version="1">MVMDATHSAAHSARSVGREFVRQYYTLLNQAPAHLHRFYNHNSAFIHGGLDNTDRDVIPAVGQKEIHQKIQELNFRDCHTRISQVDSQATLEDGVVIQVTGEFSNAGEPMRRFTQTFVLAARAPKTYYVLNDIFRYQDLGFPDEEVELETEPSNDIPERPETEEGRSEVDEDDQGQGQAPVQVEHHIAQQAAQQPLPPQAQPVIPPQQMYYPPTSNQMIVVNGTIHDPEAMMNQQPPMMPIPQQPAAPFVEPAAEFTQEEAPVEQQPESQSEETRVEEPQEPPTENFNQQPVNEAENEQTASSGVNNKPKSYARTVRSNAIGGSCNIIPKTMSPPPVSNVRNEERPSIDVWNQNNTNMSSNVMSSGPVLQHQYNRMQNSQQQPQPQRPRVGPPQKDNRGGERRRDWPDHHQLFVGNVPHSATENELRIIFERFGKVADLRIFSKGNERSKGPQGSNNSMRGVPHYGFVTFEDSNVVSKVLAACKKNKPRIPGDNMRNQDNMRSSMGPQQRGPGGPGVMRGGQHPRGGRGGFSRDGRGGMRQPGMGNTGGYQNRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2EC46</accession>
    <name>A0A8J2EC46_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS1390</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001116">
        <property type="protein sequence ID" value="CAG5075236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2EC46"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="10"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5075236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="129" mass="14504" checksum="61552076AE0253E0" modified="2022-05-25" version="1">MFILESTYRSMSSDPVIKPNPDVTPEADDSTNDLGQIFVNGKKCEIPEGVDISNLSIINNRCPEFSTTSNNKSTIRRKNPITSNEKKTDSKTKIPETTTLCPPFTRRLNELIAEIEKSPVLFRLGKKKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2ECS6</accession>
    <name>A0A8J2ECS6_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Similar to CEP135: Centrosomal protein of 135 kDa (Homo sapiens)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HICCMSTLAB_LOCUS1186</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
            <location evidence="1">Centrosome</location>
            <location evidence="1">Centriole</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the CEP135/TSGA10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001116">
        <property type="protein sequence ID" value="CAG5074975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10254663at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005814">
        <property type="term" value="C:centriole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051877">
        <property type="entry name" value="Centriole_BasalBody_StrucProt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20544">
        <property type="entry name" value="CENTROSOMAL PROTEIN CEP135"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20544:SF0">
        <property type="entry name" value="NUCLEOPROTEIN TPR_MLP1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57997">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="921"/>
            <end position="945"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="984"/>
            <end position="1007"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1120"/>
            <end position="1220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1236"/>
            <end position="1294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1363"/>
            <end position="1394"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="72"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="147"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="536"/>
            <end position="913"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="987"/>
            <end position="1007"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1120"/>
            <end position="1130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1131"/>
            <end position="1147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="1202"/>
            <end position="1214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1236"/>
            <end position="1250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAG5074975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="1394" mass="160248" checksum="F6568AD1599ABBF1" modified="2022-05-25" version="1">MLFLELLFPELLLRNSCSLNYGNKKRTVFPLRKPVLEADLLPIDASDNNRYINLSKVDQRTVDLVAMGDRKISSLTHELSKLKNELSQQKDNIVLYREQLALKDKEVYRLKKIVEAKIGKNCTCRKNERCVECNLLGSNKLSEINEVRVLQQAKLNLEQQLRDALDKQHDAMTQAMKLAERNEELEKELKDIDHIALAVEADCNSTVKENNKRVSQLQEKLENTMAQIRQLETNLLGEKRTSQELRADLESCRAEKRNIQRSLDNLEEENRQLTNRLNDLNIIDKRLSHDTSSKVAEKADKIKQLEKTIHQLERDKNYYREEWNKVLSQRKDADTTELWSQICELKQQLNEKELKIMELQRERKELAREKFELENKLQTCRSVGSCGCFSENGSRNSQLKVLERERDSARTDVNRLTEERDILRERLKLATDAHTSEQRRLRERLRDLELKLEDVEREKHNYILSQESRRSALTGLEDQLEDVKEELRRTKQELTSQRTQYFQLRALQDQTDQALGDVQSQLHHSEAELTKAVEHSRDMEQQNIQLNNVVKEQKQEINTLRTSMARLDREKDQLLMELDEKTEKIAGLEREVMLKEQQASGIEQQLRDMQRKNQICVDQTAEQERQLRNLQMELENSSRQMAAAANDRDNALMENRRLQDELAAVTCEFRTLQRELEASKAESHDLKRQLQTYENERTEMLNHYRSLSLEATVLENNNHSLESEAAEARGALQSARDRLVDLERQLADKDCLIRGYEAQITELTQNVASLETQIRQQLELRGTAETDLNAVRDLCVQLDQQKEALKKEINDKDAIIAQCEAKLSRFKAENNAVHDQKSRDHVTIDRLQMLLDQARRESINYQKNNQELLNEIDRLKQRIDDLQNRLSSESAELQRCQNQAAEYSNQVAELRRKVTDERSYPYSDQMHMSGEPAPTGISPSSREFTPQELGTNIRFRDGGHPDTLRDFTATTKGLQLSKSIDGCPASKCDKSISTDAEKTRRKKTQTDKNFKPRLVDAAVSVPAVADASVSIHELSNSVEEIFEVPNVPRVPNVPPVPDVPYVPPVPNVPYVQPVPHVPMVPNVPVVPNVPMVPHVPNAPVVPHVQNVPVVPNVPHVPVVPNVSQVPNVPNRQQDNRLANDTQRQVPGTSRDKNIKNNDPVPGTSGIQSKKRGRPRKDPDDCGCTVEIQLPNCRVQVPAEPPEPPEQDENEEPSDPSDLLSRTFERVNDLTRTVQDRLNSMSFSGEASQPSRGRDSFRRSGISENENEVIVEESRLPAPPRPPKQKKPPKENQCDLTRCHKCPMVRPPRQHVQLLRRNIQPIHTSSPVLSSHAISRPNHRYHLRSHAKTVYKIEDGAAKVISQTWEESSSSGSEVAPVRRKKSRKLSDYSDFLYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2EGD9</accession>
    <name>A0A8J2EGD9_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Similar to SNX25: Sorting nexin-25 (Homo sapiens)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HICCMSTLAB_LOCUS1084</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sorting nexin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001116">
        <property type="protein sequence ID" value="CAG5074851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2EGD9"/>
    <dbReference type="OrthoDB" id="120967at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06878">
        <property type="entry name" value="PX_SNX25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08720">
        <property type="entry name" value="RGS_SNX25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.167.10">
        <property type="entry name" value="Regulator of G-protein Signalling 4, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003114">
        <property type="entry name" value="Phox_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016137">
        <property type="entry name" value="RGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036305">
        <property type="entry name" value="RGS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044926">
        <property type="entry name" value="RGS_subdomain_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037899">
        <property type="entry name" value="SNX25_PX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013937">
        <property type="entry name" value="Sorting_nexin_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22775">
        <property type="entry name" value="SORTING NEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22775:SF48">
        <property type="entry name" value="SORTING NEXIN-25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08628">
        <property type="entry name" value="Nexin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02194">
        <property type="entry name" value="PXA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00615">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00313">
        <property type="entry name" value="PXA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00315">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48097">
        <property type="entry name" value="Regulator of G-protein signaling, RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51207">
        <property type="entry name" value="PXA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50132">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="30"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="domain" description="PXA" evidence="6">
        <location>
            <begin position="99"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="RGS" evidence="4">
        <location>
            <begin position="374"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="domain" description="PX" evidence="5">
        <location>
            <begin position="584"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="521"/>
            <end position="572"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAG5074851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="908" mass="104175" checksum="7C55900ED0182B47" modified="2022-05-25" version="1">MNFYNKKVVITTSGVVSIAVVLAWRNLFSLFVYLLLTLSCSVIGPLVIILIHIALSPKHQTGMNTLKTTVELDAFRTMLMKGYEPKAAIRQTKYPVIFTRSVDSSLQNLLDLIFRDFVKSWMTDISVFPDELILTMKQDLWLGLQTLNTRLSRIDHTRLIASSLVSKVTFHFEKIRIAQSAVCEGSDPIFILSSHLMSPNLELEYLRSISTLFITHFLPRSYSLSPSKFLIREILTQKILKPAINLITDPDYINLKILAYIEQQQLAEAMHRKTYEYAESFEDFIRMIKGSRDLEVLKHIRYNIVTEIMQATTIENVKRAQGLDLDANAKDIQGRKLKRYISQLTFAKTTCEHHMQSLGWDGYPMQDLEEEQIPLAAILDSIVGRRFLTAFLESVSSQGLLGYWAAVQELRAADKSAWHQLGAEIFYTYIRSPTAEIKVDKTVRKDMEAFLMGDKGPQVFYQVQEDVVKIIEDKYYSSFLVSPQYKQMQEALISERPDLSDERVSEVASETLVGEHSTYARSKLDQLAEKLNNKMQALQALKSSLKPESRVLSILAKEVEFLQGEKRQLEAHLSHTEMWAEHLGKWRCDVQSGEIPDNGEPPQFILVVHMAQEENDEGISTGWVVFRKLPEFHELHRKLRLVCSSVKTYELPSQPLKFFGKTDRNALEKAKNQIQRYVNFILEDDKLNQSEALYSFLSPSSEHLKHVAPSPKKSRFSLATLFKGSNSGESQKDEDDDFSLLLEEDRPGQADFSGKDAIAEPLYALVGEIFDLRGVFRWLRKSLITFVQITYGRTINRQVRDTVAWVFSEPMITYYLQLFTKSWWPNGQLAPSTPPRTDEEKLKTRGEARRQFLNNIPEVLASLVGAQSAQKGATKVFDTLQNVNLNKQLFYDILEVVLYEIFPELYRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2EHB2</accession>
    <name>A0A8J2EHB2_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Similar to Selp: P-selectin (Mus musculus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HICCMSTLAB_LOCUS33</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030000287">
        <property type="protein sequence ID" value="CAG5071324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2EHB2"/>
    <dbReference type="OrthoDB" id="547680at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00033">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.70.10">
        <property type="entry name" value="Complement Module, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050350">
        <property type="entry name" value="Compl-Cell_Adhes-Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035976">
        <property type="entry name" value="Sushi/SCR/CCP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000436">
        <property type="entry name" value="Sushi_SCR_CCP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19325">
        <property type="entry name" value="COMPLEMENT COMPONENT-RELATED SUSHI DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19325:SF497">
        <property type="entry name" value="SUSHI, VON WILLEBRAND FACTOR TYPE A, EGF AND PENTRAXIN DOMAIN-CONTAINING PROTEIN 1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00084">
        <property type="entry name" value="Sushi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00032">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57535">
        <property type="entry name" value="Complement control module/SCR domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50923">
        <property type="entry name" value="SUSHI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 5" id="KW-0768">Sushi</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="267"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="8">
        <location>
            <begin position="52"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="128"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="193"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="130"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="149"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="208"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="95"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAG5071324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="295" mass="32340" checksum="829A1417235E96C0" modified="2022-05-25" version="1">MNQKISTEFKEFIFFSLFRYLLDNGTFFVGRARLTCDIDERWNGPPPRCEPIRCDPPPLVSHSTIQLDEMNADNNLDNKNTNRSLIVGSIVTYTCDKGYQVSGSRQILCLPTGLYDHPAPVCLLEESRTTTRATSRPPVTRGKPFYPARTRTTTEQTSTDSTNAAAEEKISLAELPATVREAAVKKPAVSLYRPFSSSSSSPIQHTSNYNNNNNNNNNNNSDDDHPQDNEISGSGVDNARAKIASGVAEPTGPFRVDSTGYQPKLSLGGMITLGVVGFVIVVSVIATTVVVFMKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2EHP5</accession>
    <name>A0A8J2EHP5_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Cytoplasmic (Caenorhabditis elegans)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HICCMSTLAB_LOCUS38</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030000330">
        <property type="protein sequence ID" value="CAG5071436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2EHP5"/>
    <dbReference type="OrthoDB" id="372395at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017101">
        <property type="term" value="C:aminoacyl-tRNA synthetase multienzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004815">
        <property type="term" value="F:aspartate-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006422">
        <property type="term" value="P:aspartyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004523">
        <property type="entry name" value="Asp-tRNA_synthase_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43450:SF1">
        <property type="entry name" value="ASPARTATE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43450">
        <property type="entry name" value="ASPARTYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-tRNA synthetase class II (D/K/N)" evidence="5">
        <location>
            <begin position="1"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAG5071436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="112" mass="13084" checksum="A59C0C6DC2FCFE7B" modified="2022-05-25" version="1" fragment="single">MAFKSHYHEVVDTIGYMFTEMFRRLRDKHSDLIAIVNQQYPAEPFEWLDPALKLEFSQAREMLAEAGVVLGEEDDLSTADEKLLGKLVKKKYSTDFFILDKFPLAVRPFYTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2EKQ0</accession>
    <name>A0A8J2EKQ0_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS2119</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001116">
        <property type="protein sequence ID" value="CAG5076138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2EKQ0"/>
    <dbReference type="OrthoDB" id="7693528at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="283"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="126"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5076138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="323" mass="37348" checksum="5DAF8B90C2021071" modified="2022-05-25" version="1">MANNSFKFKESCNEIECSNYSCNCCKKNKDNKSSSAAAATAITTTNFSNLNDKMKNGLHMIEKRYSHLNERRQYLIEKIYNIEKTIPLLMVYNSSSSNDFSSFIDAISPVAHHDNQIKNDSNYLNNNDIKNSIKDLNDQVTQLYDEIIKIEIEYEESIMSLESLQAINLELENKLSNIGQKNKTPEIETLDNLYYIISQNNTDNDDDDDDDNNNNNILNCLQKLKLLVKEEIRLKNCINLLEKREKCFNQQIDKLLFVPKNIAPCNKASQHCIGKNCHKRKDKKSMDNIESQSDDINNNKQDYNDDDIDIDKYCDCCPLSKKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2EKW8</accession>
    <name>A0A8J2EKW8_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Similar to Tret1: Facilitated trehalose transporter Tret1 (Culex quinquefasciatus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HICCMSTLAB_LOCUS2241</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Trehalose transporter subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001117">
        <property type="protein sequence ID" value="CAG5076646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2EKW8"/>
    <dbReference type="OrthoDB" id="6612291at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051119">
        <property type="term" value="F:sugar transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17358">
        <property type="entry name" value="MFS_GLUT6_8_Class3_like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000218">
        <property type="entry name" value="facilitated trehalose transporter Tret1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000055">
        <property type="entry name" value="Facilitated trehalose transporter Tret1-2 homolog"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044775">
        <property type="entry name" value="MFS_ERD6/Tret1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050549">
        <property type="entry name" value="MFS_Trehalose_Transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48021">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48021:SF47">
        <property type="entry name" value="GH17672P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="15"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="45"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="69"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="103"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="127"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="212"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="249"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="276"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="310"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="345"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="375"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="410"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="451"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="480"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="504"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="538"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="564"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="648"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="690"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="714"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="747"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="786"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="817"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="857"/>
            <end position="876"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="896"/>
            <end position="918"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="925"/>
            <end position="943"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="949"/>
            <end position="971"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="983"/>
            <end position="1002"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1008"/>
            <end position="1029"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1093"/>
            <end position="1115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1135"/>
            <end position="1152"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="11">
        <location>
            <begin position="1"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="11">
        <location>
            <begin position="410"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="11">
        <location>
            <begin position="855"/>
            <end position="1181"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="1181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAG5076646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="1181" mass="128083" checksum="7993970A2DCD074B" modified="2022-05-25" version="1" fragment="single">LSAKDSWLPVSEEQGSWVSSLLAIGAMAGAFPAGSLADKLGRKKALLLLAGPFLLSWTMIIFAKSVWVLYIARFVGGISVGASCVLVPTYIAEIASPSARGTLGAIFQLFLAFGIVLTFVLGSTVSYTVLGILCGLVEVIFIAAFFWMPESPMWLVGQGRKPEASIALGVFRGDGYDTYEEISEMQREVEENTTKKSSVFDLIKTSGARKAVLASFGLMAFQQLSGVNAVIFYTVTIFKAAGSSLNSDVAAIIVALVQAVMAGVAALIVDRSGRKPLLIFSSSFMAISLVALGLYFNLKDGGKDVSNLGWLPLVSLTLFMIAFSVGLGPIPWMIMGELFTTETKAMASGLAVMLNWFLVFLVTKTFPSMKEQLGAAVTFWVFAGIMVVATVFEYFFVLETKGKTLQEIQTNIAVVAGGATLGWTSPILLMLKKDPVSPDNPIGRPISEDEASWIGSLTPVGALVGGFFAGYLAETFGRRTTLLSSVIPSTLGWILIATGQSVEMFYVARFIFGVALSISFAVLPMYCGEIAETSIRGILGSFLQLFITVGLLWAYSIGPYVSYTSFWISCAALPIAFFVLFFTMPESPYYLAAKGRKEDVISALVRLRGKSKDAVRAEADEIETTVRDAYNKEAKITDLFTIKANFKALIFTCLLVIFQQMTGINVVLFYSENIFASAGNSGISSSIETIIVGIVQFLASGVTPLVVDRLGRKILLIISGTGTAISLGILGLFFYLKDEAKNDVSNIGWLPIASLIIFIATYSIGWGPLPWTVMGEMFSTEVKSKASGIVVFACWFLGFLITKYFSNIAAAWGQYTAFWLFGVFCVLSVLFTVFILPETKGKSLQEIQDELSGTMNLCVMGGGAIMVWSSPILLMLQSDPVEEDNPLDRPITDEEASWIGALSPMGTLVGCLFPGYLAEKLGRRTTLLCSIIPMAVSWALIFTGKSIEFLYAARFIGGLAVAISFGVIPVYCGEIAEPSIRGILGSFFQIFITFGQLWAYSIGPFVSYMNYCIACAVLPIAFFITFYPMPESPYYLAAKSRKEDVIRVLMRLRGKKREEVEMEANEIEVSVQEAYNKQATILDLFKVKANLKALIATCALIIFQQMSGITVIVLYSELIFSSAGEFGLSSSVQSIIVRLVQFLGTCINPFVVDRLGRKILLIISSSGAGLSLVGKTNHFIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H2J0</accession>
    <name>A0A8J2H2J0_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS1461</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001116">
        <property type="protein sequence ID" value="CAG5075307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H2J0"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5075307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="127" mass="14234" checksum="31C1E078917A729C" modified="2022-05-25" version="1" fragment="single">MVFQFRIETESPKNDILAPQNTKTTPPATPKTYTWKKQFKIKSFKGPFEAGDFLKNRYKGPLKLAIFCRTHTIPLHNIKNHQGISCPGTSPPATPNPSAEEGSPCTFYVNGKFQRILTYFGSGITNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H333</accession>
    <name>A0A8J2H333_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">ATP synthase F(0) complex subunit e, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HICCMSTLAB_LOCUS1812</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Subunit e, of the mitochondrial membrane ATP synthase complex (F(1)F(0) ATP synthase or Complex V) that produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. ATP synthase complex consist of a soluble F(1) head domain - the catalytic core - and a membrane F(1) domain - the membrane proton channel. These two domains are linked by a central stalk rotating inside the F(1) region and a stationary peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. In vivo, can only synthesize ATP although its ATP hydrolase activity can be activated artificially in vitro. Part of the complex F(0) domain.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) and CF(0) have multiple subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the ATPase e subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001116">
        <property type="protein sequence ID" value="CAG5075690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H333"/>
    <dbReference type="OrthoDB" id="9982108at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015078">
        <property type="term" value="F:proton transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015986">
        <property type="term" value="P:proton motive force-driven ATP synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008386">
        <property type="entry name" value="ATP_synth_F0_esu_mt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05680">
        <property type="entry name" value="ATP-synt_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="4 11" id="KW-0138">CF(0)</keyword>
    <keyword evidence="5 11" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="7 11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 11" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU367005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAG5075690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="105" mass="12236" checksum="E302F08636A7C0A7" modified="2022-05-25" version="1">MSAVELNPRPVRVSPLIKESVAGYLAFSRWTLLTAGIMYGLFYQNRFSKKEAAFQEVEMKRKAIRDKQLAEEKKRLAEGGYFRLFCIFIIIIISRDKCQKSVLQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H372</accession>
    <name>A0A8J2H372_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Similar to SUB1: Activated RNA polymerase II transcriptional coactivator p15 (Gallus gallus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HICCMSTLAB_LOCUS635</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transcriptional coactivator PC4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001114">
        <property type="protein sequence ID" value="CAG5073849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H372"/>
    <dbReference type="OrthoDB" id="2505440at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060261">
        <property type="term" value="P:positive regulation of transcription initiation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.31.10">
        <property type="entry name" value="Transcriptional Coactivator Pc4, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003173">
        <property type="entry name" value="PC4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009044">
        <property type="entry name" value="ssDNA-bd_transcriptional_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045125">
        <property type="entry name" value="Sub1/Tcp4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13215">
        <property type="entry name" value="RNA POLYMERASE II TRANSCRIPTIONAL COACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02229">
        <property type="entry name" value="PC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54447">
        <property type="entry name" value="ssDNA-binding transcriptional regulator domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Transcriptional coactivator p15 (PC4) C-terminal" evidence="8">
        <location>
            <begin position="104"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="50"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="59"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAG5073849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="169" mass="19596" checksum="0521E65FD6BE6CE6" modified="2022-05-25" version="1">MLIHFCNSVKSLYLSRCFCSTTILFSNKYKDFWKEELSLNIFNMPKKSREYVSSDESESGSHSEEEKPKKKPKREEKKSKKEEKEDKPAKKASSSKVDDEEPTWSIGNKRQVTVRTFKGKLYIDIREMYLDANSGDLKPGRKGISLTPENYNKLKDILEEVDEAVARKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H3N2</accession>
    <name>A0A8J2H3N2_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS1403</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001116">
        <property type="protein sequence ID" value="CAG5075249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H3N2"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5075249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="30" mass="3731" checksum="C244F97592D31357" modified="2022-05-25" version="1">MLLFFELNQNTYRQLKFHSYLSIHDMKTLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2023-09-13" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H4U1</accession>
    <name>A0A8J2H4U1_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS12</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030000100">
        <property type="protein sequence ID" value="CAG5070423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5070423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="10" mass="1199" checksum="D7538CA5B9C68412" modified="2022-05-25" version="1">MIVRMFSSTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H5S5</accession>
    <name>A0A8J2H5S5_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS1873</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001116">
        <property type="protein sequence ID" value="CAG5075811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H5S5"/>
    <dbReference type="OrthoDB" id="8191408at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="163"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5075811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="228" mass="26486" checksum="73FE3ACACD60B847" modified="2022-05-25" version="1">MERNYPMTTRSRSENDRIVFYDNRNYYSERLPDFRDELISQGLYPPSPQLQNNRARRSNSVCTQSDRPKRFRSGETGNRRRNSIHGRITHGPTPLGDGRRASVKRKVSARRLNSISRKSSTRLSNTSKTYHYPPEEMINDDHKIKVVEKSLMELEQARKQRQIVIIILGIFVILVVTSVLIVIITLTRRSFRTSIATPLSLHHNYSVRQNEPKWHNASQSMTNTSIPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H6B5</accession>
    <name>A0A8J2H6B5_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Similar to INTS2: Integrator complex subunit 2 (Homo sapiens)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HICCMSTLAB_LOCUS2747</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Integrator subunit 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001117">
        <property type="protein sequence ID" value="CAG5078461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H6B5"/>
    <dbReference type="OrthoDB" id="70899at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032039">
        <property type="term" value="C:integrator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034472">
        <property type="term" value="P:snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026236">
        <property type="entry name" value="Int2_metazoa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029321">
        <property type="entry name" value="INTS2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28608">
        <property type="entry name" value="INTEGRATOR COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28608:SF1">
        <property type="entry name" value="INTEGRATOR COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14750">
        <property type="entry name" value="INTS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02105">
        <property type="entry name" value="INTSUBUNIT2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG5078461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="1114" mass="125067" checksum="453F01DF531D3009" modified="2022-05-25" version="1">MQMNMTISSRVFTAIQNVNIRELSQCSQREIRPLLPCLVRMSLISPLDITRECVEARKEILTILSGIESVNSIVALLSIDFHALETDVRKEIQLRQKIGNTQGDSILAQSVQGGLAQEFERSESTLRIRLVLSELLFVSSQIQEHQKTNDFSIKQSDLFGPAVYMEEISYVICIALAELPALLSISDIAETLLHVKHGPEIICWVVANSPDSFFDVCTHLIANGERQEESALGRIRTQALTMLCRMNPSQSLAIRAKCVELCRMPALAITLSLEKNSLDSPESDVVAFVSGLLLGSDQQVRNWIGLFIRNGQKRKWESHSALQSLRDEILTRLKAIVTDVTAADGQLVESQVVKASALLRLYCALRGIGGIKFQDDEVTMIVQLLTSHPPPSPAGVRFVSVGLCMLIACPSLIGHHQLEKKSIEWVQWLVREEAYFESASGVSASFGEMLLLMAIHFHSNQLSAICDLVCATLGMKVPIRPNNLTRMKQIFMQDIFTEQVVTAHAVKVPVTANLNANIPGFLPVHCIHQLLKSRAFSKHRVPIKNWIYRQICNSTAPLHPVLPALVEVYVNSILVTGSKTTEHTNKPITEDEIRRVFQHSVFGENFKSSKRSALSIMELDAENIDVDTTKPSLTSQLLFLYYLLLYEDVRMTNMSNFLSQGRKVKSYSVEFLSELPMKYLLQQAQRDQLNYASLFSPLLRLLATHFPHLSLVDDWLDDEMINIDSTAANYDNVVINELTVKEAFKNIKSCPSRTGRVLRQMMIMKPTEIWGYSETIISYFKTILDEKVPRYIQELYKQVWLRFNTVLPRFLWVMSINALLMEIPTVQNVRLTQENIVLDPLQVLRCDARVFRCAPVLSVILRILQATLAASRSQLSRHMQDRPMTEKVGQLTNESEREDLRTALVAGQESAAVQILLEACLETEEDRVVPGQLWSLREIRSVVCSYLHQVFITDPSLAKLVHFQGYPRDLLPITVAGIPSMHICLDWIPELLSQPEPEKQIFAVDLASHLAVQYALPKALSVSRLAINTLITLLGVLPAKERVVLFIPVLSALTRICLAFPPLAEDTTGLLLQLGRISSAQAALGDKSAEILCHQVNLTFSSLLQKAILQSKVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H6E5</accession>
    <name>A0A8J2H6E5_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Similar to SMYD4: SET and MYND domain-containing protein 4 (Pongo abelii)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HICCMSTLAB_LOCUS2522</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001117">
        <property type="protein sequence ID" value="CAG5077649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="7770870at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042826">
        <property type="term" value="F:histone deacetylase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008170">
        <property type="term" value="F:N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008276">
        <property type="term" value="F:protein methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052097">
        <property type="entry name" value="SET-MYND_domain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46165">
        <property type="entry name" value="SET AND MYND DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46165:SF2">
        <property type="entry name" value="SET AND MYND DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01360">
        <property type="entry name" value="ZF_MYND_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50865">
        <property type="entry name" value="ZF_MYND_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SET" evidence="9">
        <location>
            <begin position="325"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="domain" description="MYND-type" evidence="10">
        <location>
            <begin position="370"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="domain" description="SET" evidence="9">
        <location>
            <begin position="943"/>
            <end position="1120"/>
        </location>
    </feature>
    <feature type="domain" description="MYND-type" evidence="10">
        <location>
            <begin position="988"/>
            <end position="1027"/>
        </location>
    </feature>
    <feature type="domain" description="SET" evidence="9">
        <location>
            <begin position="1454"/>
            <end position="1735"/>
        </location>
    </feature>
    <feature type="domain" description="MYND-type" evidence="10">
        <location>
            <begin position="1499"/>
            <end position="1538"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="263"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="881"/>
            <end position="913"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="1392"/>
            <end position="1424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAG5077649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="2168" mass="249271" checksum="B8130F4ABC40F29F" modified="2022-05-25" version="1">MYLESLVQMRKKNFYDYDITSPEEVEKLMLWIFTIINVIGNFDVYPCEQISVGKGLLHCIIKWIEQIYLQFLHKIQAYQFAARLLKFAYNYNLSKLLDYIYNFIDSKANEVINTPECQTFITHAYATEHFSDAKTDEDFIKVALKIHGKKEDELPNLSDIKKPKCEVKAKQMLDKAKRGCSSISLGKSIEVYNTAMSLALPGSELLAHAYANRSIVLSNAAMYEESLKDIEQALKANYPDHLKALLFARKAKNLFALDPTADIKDTLNEARQWALKMNDKEKKKLLDNLEKIKKKKYKKPVKERDNRILMPLPHNDNPIIKDTSGSITINYSEKFGRHIVATKDMMVGEVVSVKQAYALVLSWEYRLKRCWNCSKHCWSSVPCNTCSNVIYCSEECRNVAWKDYHGIECSILTGLLSLAHHYEDISLMSLRLFIKAIKEFGTVKALYKNIQKMDSTEDFIMKSFTDGIYDDKKYASVYPLSRKPMNLRFQVQCAVKTIHYMYLMALMTDIFGKKMENMEELRNYEHAVFVGKLLYHHTVLSSSNRYAIPVPSTNEQLECGGVLNPLESLFNHSCDANTGYFLCRDMSTFMTLQPIKKGEQLFISYGPEYHEVPTPKRREELQKIQNFWCDCQACINNWNPGHVHPSIFDKLPATIVTNLSLIFLKCICQIQEQNFYDYDTTSPEEIQKLLLCLFTAIHLVGYYEINITRKNFTALHYQMDRELPINRLIHLMDKFVTLSMHALAVDHLHDAKTDEDFVKIALKMHAEQQDELPNLNDIKKPKCEVKAKGMLDKAKRGFSSSSLGKTIEVYNTAMSLALPGSELLAHAYANRSIVLSNAAMYKESLKDIEHALKANYPDNMKALLFARKAKNLFALDPTADIENTLNEARQWALKMNDKEKNKLLDNLEKLKTKTYKKPVKERDNRIFVPSPPNDNPIINDTSAAIAINYSEKFGRHIVATRDMMAGEVVSVKRAYALVIACDYRFKLCWNCSKYCWSSVPCNTCSNVIYCSEECRNVAWKDYHDIECSILNGLFTSIHYYDDIGLMSLRLFIKAMKEFETIYAPTKGELLYCGGILDPLESLYNHSCDPNMGYFLCRDKTTTFITLQPIKKGEQLFISYGPDFHEMPTPERRELLQNDRSFWCDCHACINNWNSKHVFPSAWNKLPKTLATKMSMILLACIVHMKKQNFNDLDTTPPEEVKKLMSDIFTIINVVGRYDIYPCDEISVGKSLLHCIIKWIENLRDKLVMLKIDLLAAERFSGAKTDEDFVRAALKMHVEQQDELPKLKDIKKPKCEVKAKLMLDEAKQGFSSISLGKTVEVYNTAMSLALPGSELLAHAFANRSIVLSNAAMYEESLKDIEHALKANYPDNMKASLFARKAKNLFALDPTADIEDTLNEARQWALKMNDKEKNKLLDNLEKLKTKTYKKPVKERDNRIFVPSPPNDNPKIKDTSAAIAINYSEKFGRHIVATRDMMAGEVVSVKRAYALVLSCDYRFKLCWNCSKHCWSSVPCNTCSDVIYCSEECRNVAWKDYHDIECSIVNGLLSSVYPYEDISLTSLRLFIKAIKEFGTVKALYESVQKMDSKEDFIMKSFTDGIYDDKKYASIYSLCRKPMDTRFQVQCAGKTLQYMYFIALTSNIFGKKMENMDELANYEYAVFVGKLLYHHTVLSCNNRYAVHDSTNDELVDCGGLLSSLQSFFNHNCDPNTDYFVCRGMTTFITLQPIKKGEQLFISYGPEFHEVPTPKRREELQNIRNFWCDCHACINNWNPGHVFPSAWNKVSKPIATSMSMMYLESLVQMRKKNFYDYDITSPEEVEKLMLWIFTIINVIGNFDVYPCEQISVGKGLLHCIIKWIELAPNLISEFATLKIDLLATEHFSGAKTDEDFVRAALKMHVEEQDELPNLRDMKKPTCEVEAKRMLNKAKQDSSIHNTAMSLALPGSELLAHAFANRSIVLSNAAMYEESLKNIEHALNANYPDNMKVLLFARKAKSLFALDPTADIEDTLNEARQWALKMSDKEKNKLLDNLEKLKTKTHKIYFDSLFYLKIFLSADSIMKSFTDGIYDDKKYASVYPLRRRPMTTRIKVQCARKALQYMYFMALTSDVFGKKMKNMDELKNYQYAVFVGKLLYHHTVLSSTNRYAIHVPSTNELLKCGGLLNPLESLRQSQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H6I4</accession>
    <name>A0A8J2H6I4_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS2645</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001117">
        <property type="protein sequence ID" value="CAG5078104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H6I4"/>
    <dbReference type="OrthoDB" id="504708at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39069">
        <property type="entry name" value="ECDYSONE-INDUCIBLE GENE E1, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39069:SF8">
        <property type="entry name" value="FI17111P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5078104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="148" mass="16663" checksum="2E1039B2A26AF419" modified="2022-05-25" version="1" fragment="single">SLGKFCQFNTDCDDRENLKCSDDKICACKDHYALLNGTCIPVSNGFCSHNIECKLHGFYCVNNECQCKSNFTLVSEHQCVETNLVSSCIDSIDCGDFWHAKCVNNKCVCTYNHVAINNSTCYPISGGLCWTDHQCPEQNFECIDFHCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H7K9</accession>
    <name>A0A8J2H7K9_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cc_odve66_17</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS2871</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001117">
        <property type="protein sequence ID" value="CAG5078890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H7K9"/>
    <dbReference type="OrthoDB" id="7680719at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.100">
        <property type="entry name" value="Chondroitin AC/alginate lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008929">
        <property type="entry name" value="Chondroitin_lyas"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="140"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5078890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="584" mass="66592" checksum="E0A4BB2C6797EA33" modified="2022-05-25" version="1">MDIVSFIVLIVILAGIWFAYTRFKKKKNVTIKELSVQERIEKLRTAIKDPKVVLSSGQQNKIKTYKDLAVDIEKEYKGWDTNLAKMKDMCFDGCKFLDFHLAKVEPVGLKIADAMVIKLLGKLDSVKGEVIKVSIWEKDWYYTSINLTYFLALYVYIGTNNDLIEGCKKQILRILPSVGVGLTKPLMGLTLFKATVSRLCVTYLMPDKFKKDITSAKFTQVKEFMNLTHVEDDTVQDGYYDDGSMILNGFASYDRLESRLGFYEKAYRSMGLQSNIKDLAVTIFPKLTHPKVRWSPPGLFRNNNDRIARWWPSSDTEINLIPFIGLGVFKCPEFMFFVRVQRPGIHPNYPAIPELAAGCIQIRRIFLKDNNTYPKNLLNTNLKDEPGVLSKVGGSVCELKDKTGGNFYCSNVSSFIGCIDDLMFWKNSYKFIELFGDVTVTEAGVISATGFQACYKIDNNSNESFKFRYKDTRMKKCYTNPTGSTEFFDVPQKDRGGSKKTKFTWTMAEKWIDYKVALTADGMEFETSTSKKYKVKKITGDNEPYVVTCGSTTLLGSSSSRIPSEITHETIKYKRNAKTMMYEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H7U2</accession>
    <name>A0A8J2H7U2_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Similar to CSMD3: CUB and sushi domain-containing protein 3 (Homo sapiens)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HICCMSTLAB_LOCUS3687</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5082931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H7U2"/>
    <dbReference type="OrthoDB" id="406096at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00033">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="CDD" id="cd00037">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.260:FF:000105">
        <property type="entry name" value="Sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.70.10">
        <property type="entry name" value="Complement Module, domain 1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018378">
        <property type="entry name" value="C-type_lectin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006585">
        <property type="entry name" value="FTP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035976">
        <property type="entry name" value="Sushi/SCR/CCP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000436">
        <property type="entry name" value="Sushi_SCR_CCP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46393:SF7">
        <property type="entry name" value="COMPLEMENT C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46393">
        <property type="entry name" value="SUSHI DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22633">
        <property type="entry name" value="F5_F8_type_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00084">
        <property type="entry name" value="Sushi"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00032">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00607">
        <property type="entry name" value="FTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57535">
        <property type="entry name" value="Complement control module/SCR domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00615">
        <property type="entry name" value="C_TYPE_LECTIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50923">
        <property type="entry name" value="SUSHI"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="6 8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="1 8" id="KW-0768">Sushi</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="592"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="12">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="11">
        <location>
            <begin position="213"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="12">
        <location>
            <begin position="342"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="12">
        <location>
            <begin position="400"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="12">
        <location>
            <begin position="460"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="12">
        <location>
            <begin position="518"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="59"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="685"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="72"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="22"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="370"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="430"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="488"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="548"/>
            <end position="575"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAG5082931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="707" mass="77128" checksum="202B2D944222B4D2" modified="2022-05-25" version="1">MNSKVSLSNDSLSAGTLATYTCDAGYELFGQPTTTCSSRGRWQGELPFCGTNVGFRKPANQSTTVRGGDASHGNDGDTGTEHDGKRCTETQNEPSPWWKVDLLKAYSVKVVRVTTRGCCGHQPLQDIEIRVGNSSVELQRNPLCAWFPGTIEEGITKTFICARALVGQYVFLQLVGVEGSLSLCEVEVFATNEFSIDRCAHAGTPADADIAAFDSTCYEFIVTKGGSFHDARNYCKSRSGDLVHGFKGVSSTFILNNLEKRKDKLKTQLVWIGAQKEPSITARTWRWVDGEIVQKPSWGKDQPNNYNGEQNCVVLDGGRSWLWNDVGCNLDYLHWICQSKPSSCGSPDKYENTTIIGTKKAIGSAIQYVCPDGYMLIGNESRVCEVDGFWSGKPPTCKYVDCGTLPDLDNGEVKLVNKRTTYGAIADYGCKDNYTLVGDTSRRCGDGGIWSGHQPKCLFDWCPEPPEINGGLVIKTGKRTGSTATYTCQNGFILFGDNVLTCNVGGGWSGKVPQCKFIDCGAPAQIEYGEVNLLNKTTTVGSITVYTCQDDYWLVGEARHECTKDGKWSHEAPSCELISNEIAEAQGVGTSVGIGAGVIIFILLILGLVYLRLRKATPVKNTENIQAAERKEDQNAAVMSYSSLNDGTSNKMYENVPEDGLYDSPYSGSGSTYGYSRQNGRTYNRSGHYEAEPPPRNGITINGVTVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H897</accession>
    <name>A0A8J2H897_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS4032</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5084160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H897"/>
    <dbReference type="OrthoDB" id="7691905at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5084160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="103" mass="11248" checksum="0F56E41A0CE8F9CD" modified="2022-05-25" version="1">MKGLHGHISRGNRRHVDHVDAKWDTSDMDVDDAPAASSRRALSNKEQTKDSGKSLILPSLTSLLPYVKTILVEIIKQIGGTKFEKLGQDALALVEDLVVLISS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H8D5</accession>
    <name>A0A8J2H8D5_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS3994</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5084026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H8D5"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5084026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="55" mass="6011" checksum="E148C04A853BF010" modified="2022-05-25" version="1">MIFVSPVPIVVKRHVGIRMAQMLVLLLAKKIHVNANTDMFATILAGASNLNIVQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H8I0</accession>
    <name>A0A8J2H8I0_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Similar to LST: Luciferin sulfotransferase (Photinus pyralis)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HICCMSTLAB_LOCUS3937</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sulfotransferase 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5083817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H8I0"/>
    <dbReference type="OrthoDB" id="205623at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008146">
        <property type="term" value="F:sulfotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000863">
        <property type="entry name" value="Sulfotransferase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11783">
        <property type="entry name" value="SULFOTRANSFERASE SULT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00685">
        <property type="entry name" value="Sulfotransfer_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Sulfotransferase" evidence="3">
        <location>
            <begin position="54"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG5083817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="335" mass="38620" checksum="B6C99957ED8BCF31" modified="2022-05-25" version="1">MELKFTTVEGKVGATLDRMFGVQTSFLRVEPGNCLLPPQYVTLGKKIRDMEIYPDDVWMVSYPRTGSHWAQEMVWCIGNDLDFEKAKVPLLIRNPLLESSALMVTGKYVDFFSQFGNSVENVEKTARPRYVKTHLPWELLPQQIKSKKPKVIYVTRNPKDTCVSLFHYLKLMHDYNGTFEELAELFVNDTAPMNPFWQHVLSFWNRRNEENILFLTYEEMKRDQITAIHKTADFLGKSLSEEQVIALASHLEFSKMAANPAINLEAVLANGNKIEGTSNGNGEKCENNNGIDKFIRKGKIGDWKNHMNDELTRKFDLWAEKNFKNTGLEFDYGDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H8I5</accession>
    <name>A0A8J2H8I5_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similar to B0563.6: Probable G-protein coupled receptor B0563.6 (Caenorhabditis elegans)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS4243</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5084973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H8I5"/>
    <dbReference type="OrthoDB" id="10033446at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008528">
        <property type="term" value="F:G protein-coupled peptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019427">
        <property type="entry name" value="7TM_GPCR_serpentine_rcpt_Srw"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053093">
        <property type="entry name" value="GPCR-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47760">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR B0563.6-LIKE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47760:SF1">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10324">
        <property type="entry name" value="7TM_GPCR_Srw"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0675">Receptor</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="110"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5084973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="139" mass="15829" checksum="82E0E8FEA1E29E5D" modified="2022-05-25" version="1">MTNIFNESGNNNHLCVLLEDLEMLEDPRTASLRRVSYGIVLPTICCLGIIGNIFNLIVLTRKNMRGTAYIYMRGYSAAALLAILFCVPFASRVLIHKETGRWNNWPQAFYHAHLELFLGNGCLGNIFQKKKCNQKLLHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H902</accession>
    <name>A0A8J2H902_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Similar to hts: Protein hu-li tai shao (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HICCMSTLAB_LOCUS4540</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aldolase class II family. Adducin subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5087544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3238794at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0014069">
        <property type="term" value="C:postsynaptic density"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.225.10:FF:000011">
        <property type="entry name" value="Uncharacterized protein, isoform B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.225.10">
        <property type="entry name" value="Class II aldolase/adducin N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051017">
        <property type="entry name" value="Aldolase-II_Adducin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001303">
        <property type="entry name" value="Aldolase_II/adducin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036409">
        <property type="entry name" value="Aldolase_II/adducin_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10672">
        <property type="entry name" value="ADDUCIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10672:SF3">
        <property type="entry name" value="PROTEIN HU-LI TAI SHAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00596">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01007">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53639">
        <property type="entry name" value="AraD/HMP-PK domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Class II aldolase/adducin N-terminal" evidence="3">
        <location>
            <begin position="168"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="633"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1392"/>
            <end position="1420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1456"/>
            <end position="1493"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1664"/>
            <end position="1692"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1712"/>
            <end position="1753"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2098"/>
            <end position="2138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="644"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="683"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1393"/>
            <end position="1407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1408"/>
            <end position="1420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1466"/>
            <end position="1484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1683"/>
            <end position="1692"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="2112"/>
            <end position="2138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG5087544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="2138" mass="239868" checksum="906BE0288553FAE7" modified="2022-05-25" version="1">MLHTAFIVNTINQAFMKAVVKKSNCILDYELNEALLTERGPRMADTSQHELSEPHTNGVIDGLTEEEKSKMRPADIDADMREMERRKRVEIIMNSKMFKEELERIIETQLKDGSGPCGLLQQITEMMGAQGARFNANVFKNSNCVVPINDIRGVEAKGYERGEKLLRCKLAAVFRLLDLYGWTQGLAGQITARLNADEEHFLVNPFGLLYHEITASSLVKVDMQGQVVEQGTTNFGVHVAEFQLHSTIHAARPDIKCIIHITTPTVTAVSSLKCGLLPIGPESIVIGDVSIHQYIGETVEPEEREKISRNLGPINKVMLLTNRGALCCGETIEEAFYNVYNTVLACETQLKLMPMGVENLNLLSEESKKSIYEASRKPPIPHTSSIIEPSPLAEKLEKRWRIGSSEFEALMRMLDNAGFRTGYIYRHPLIKSEPPRPRNDVEVPPAVSSLGYLLEEEELYKQGLWKGGRKGADRSRWLNSPNVYQKVEILETGTPDPKKITKWVSDGSPTHSSSTPVRIDSALQFVPKNTNPKEFKQLQQQIKDYRRADKISAGPQSHILEGVSWEEAKKMQDATISGTGEQVVLVGAASKGIIQRNFQHNAMVYKTPYAKNPFDAITDQELDQYKKEVERKTKGDIYDESQSESEALSSFNISRATHESSTAKSPIQSPISVTSETEEESRDEPRVLRIETKRVPKPSQAEVVLSDDYEASSNDEGNEEIPVGDYGRWRLDAHEEIHLERTKLITLTPLKSLNPQSKSLDNLNIFGVSSPKYKSTYPNLNSRIKSYRRRIFFDQYDKVYAQYKNSNLTSQVSQSVSNVNLNFINTNRGQSSVKQLISKYSSLALTGRNINDNTENNININTGLIKSRKRAYVPLASSSCSVCKLPRLSLPVLKLQDLQSPRLVEEAMNRQLLSETCVETESHLKECELRPVPVDLRVSPISMSPFYQFGEVQYESTPIKDVQVSKDCLPTAGSFEFVNADVNVSEADVNGNVANPLSMTSSGEKLVSDQEPSSEDVASVQTVVEKNLDCVVTNEKNLITETESISPELIDNLEWFNEPLDSLESSFAKELNDSQPWRFSSPLVSGKKYQREDSMTEVIDSINVNLTPSKSMRSLNFHLPSSDASMKYNLNSSHMSVIYSLTPTAEIQDGEEGNEHIYCGKKCPQCLILAPIESLSPTDHDSFYIWDDPIAEDEEKEDNVVDLNKTIDLFDNSIELEANVTHESADFELPEIKVEDEGEFHKDIETTVNEIIEGLEERATLIEANRLVDNVIDSACIEVNAVKSLEDQARFDGNENAQHDVKNEVEAALGNEEADIADNEERTRGGKEEIDFVGEVACKVEDNSNVDDVDIKKDISSVEEDGIGTERIVIKEEADSEIKDDDDFGILENLFEEESKPEVYAESHPEEANTEEQIDPEEVKEEISEIIHKISFNEDSEENIADKYTVVDEIIHHIIDKDSSNSSEQALERQDSHESQEESPRDTSESSESFNLKKVKENANTEIKEMQSQQESSLKIVDENVECRESKEDFINKLKAITEDVNSLDESRIKEIFFSGVINDLHLNPDGKLTAAESSEILQKLKCIVEQVNVDESSKALDGLETSNGDSTYSYALKQFKNQVEEIFKNSQASLTELDVDDVNIDNTAGKEIDSMEVDGHCEEDIAVNSSEQNEESEREEMSVDNTKSDDSKEKNEVTGKTVKFCIIEYQSEVSSGQEVQNEVDEAEKVQETGAQSSDGRESSESDESDSLVKNLSDGEKEALKLWEMAESEIERSYNGNISTTFVEYDHVDDILDTVDAKPLVHYPTHHDLRLDCLDEALNVSITRCKDKISLSTISEDDESESESEDEVCFNSSPIRNINSPMKITKVDSVCSLELIQEIDEDDIDIDKVVPDVNAKPEDVSDDDSDSVVIMSIKNIFREDDDLKIIYENVNNDIYHDDDDDDDDDINIIRETVFNKPVSDLDENHCSIENVNELKQTSSSLTEFHSCQEELSNPESFETCISHQSAQTITPRSDNNEVNSETYTISDNDADDDCTSEIVGIPHDTMYNADVSSENTVNGDHSDAHHSTFSHSSKEVELLHVHEGFVCSLVGTFHVKGSMSQDVSVSEESPKKEKKKKKGLRTPSFLKKKKEKKKSVEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H9C7</accession>
    <name>A0A8J2H9C7_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Similar to l(1)G0004: RNA-binding protein pno1 (Drosophila pseudoobscura pseudoobscura)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HICCMSTLAB_LOCUS3706</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PNO1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5083008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H9C7"/>
    <dbReference type="OrthoDB" id="1932641at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd22391">
        <property type="entry name" value="KH-I_PNO1_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22392">
        <property type="entry name" value="KH-I_PNO1_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.10:FF:000009">
        <property type="entry name" value="RNA-binding protein PNO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.10:FF:000048">
        <property type="entry name" value="RNA-binding protein PNO1 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055212">
        <property type="entry name" value="KH-I_PNO1_first"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055211">
        <property type="entry name" value="KH_PNO1_2nd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12826">
        <property type="entry name" value="RIBONUCLEASE Y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12826:SF13">
        <property type="entry name" value="RNA-BINDING PROTEIN PNO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22891">
        <property type="entry name" value="KH_PNO1_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="K Homology" evidence="6">
        <location>
            <begin position="133"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="38"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAG5083008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="228" mass="25634" checksum="813B29C75919DF66" modified="2022-05-25" version="1">MDKASGSKNTDSKSSKRRHDSESVMEVETVNGIEGKAKNKSSTKRTKNVAGNEQRKVSHRYTPLKESWEKIFTPVVEHLQLQIRFNLKSRNVELRTSPETPDISNLQKGADFVKAFVLGFEVEDALALLRLDDLFVETFEVQDVKPLKGDHLSRAIGRLAGKGGRTKFTIENVTRTRIVLADCKVHILGSFQNIQIARRAICNLILGSPPSKVYGQLRNVSSRISERF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H9Q2</accession>
    <name>A0A8J2H9Q2_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Similar to rab7: Ras-related protein rab7 (Epinephelus coioides)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HICCMSTLAB_LOCUS4562</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Late endosome membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5087635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H9Q2"/>
    <dbReference type="OrthoDB" id="1436450at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045335">
        <property type="term" value="C:phagocytic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008333">
        <property type="term" value="P:endosome to lysosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090385">
        <property type="term" value="P:phagosome-lysosome fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01862">
        <property type="entry name" value="Rab7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000086">
        <property type="entry name" value="Ras-related small GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47981">
        <property type="entry name" value="RAB FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47981:SF20">
        <property type="entry name" value="RAS-RELATED PROTEIN RAB-7A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0636">Prenylation</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAG5087635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="207" mass="23225" checksum="7B6C16FB1331DEFA" modified="2022-05-25" version="1">MASRKKVLLKVIILGDSGVGKTSLMNQYVNKKFSNQYKATIGADFLTKEVMVDDRIVTMQIWDTAGQERFQSLGVAFYRGADCCVLVFDVAAPTSFKSLDSWRDEFLIQASPRDPDNFPFVVLGNKVDLENRAVSSKRAHQWCQSKNNIPYFETSAKEAINVEQAFQTIAKNALAQESEVELYNEFPDQIKLTNDQRSNGKGDSCAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HA41</accession>
    <name>A0A8J2HA41_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Mitochondrial (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HICCMSTLAB_LOCUS4863</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATPase F chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5088477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HA41"/>
    <dbReference type="OrthoDB" id="8921675at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042776">
        <property type="term" value="P:proton motive force-driven mitochondrial ATP synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019344">
        <property type="entry name" value="F1F0-ATPsyn_F_prd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13080">
        <property type="entry name" value="ATP SYNTHASE F CHAIN, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13080:SF20">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT F, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10206">
        <property type="entry name" value="WRW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="4" id="KW-0138">CF(0)</keyword>
    <keyword evidence="5" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="76"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAG5088477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="111" mass="12991" checksum="0398ADCFB98F846D" modified="2022-05-25" version="1">MDWGNWAKYPKGYDRAIHGPFDPAKFYGKADIPFGQVKLAELPSWFGRRNIGPVAISQAIGRAYWRWQHKYVIPKYCGVAPFFQVTCASIIFFYIINYPRLSMYIIFFILL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HA52</accession>
    <name>A0A8J2HA52_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Similar to Vps8: Vacuolar protein sorting-associated protein 8 homolog (Mus musculus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HICCMSTLAB_LOCUS4999</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the VPS8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5088836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="289913at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030897">
        <property type="term" value="C:HOPS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034058">
        <property type="term" value="P:endosomal vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045111">
        <property type="entry name" value="Vps41/Vps8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025941">
        <property type="entry name" value="Vps8_central_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12616">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING VPS41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12616:SF8">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 8 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23410">
        <property type="entry name" value="Beta-prop_VPS8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12816">
        <property type="entry name" value="TPR_Vps8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="1269"/>
            <end position="1306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="557"/>
            <end position="576"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAG5088836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="1360" mass="149871" checksum="D6DE0DF47815622B" modified="2022-05-25" version="1">MAENGFESEIGSQENLAAEAINLDIDELDDTEYAIPAVDKLPSLESILTEPDCASLSGTELDINSAVASSSSSVLGPSNLLGPDPIDGSETTSIGSLLSLNSLNKPQTRNPEFPLSGVILKHAIMRGITSQIKSASEKVNGGLASAVAAGGDMLVIGTSHGLILAFDSKQTLRWCNQEARHQGSVSALGFNHDGSRLLAGFARGHILMIDSSAGKVLRVLTEVHPPGTAVLHVKFTDLPTLALCSDSGGSVFELTFTRTMGVRGCDSKCLFSGSRGEVCTLEPLLLNNLPRHPLKSYILVALATLSKVIVVCIRPRIRVVLTHPLLGPATAPPQVSWQLVVIQAPDASRVIDPVLALARESTVHFYQVCSEAGSRVRLSPLRRITLSYIISNLRWLNTRSLAILDTQERLHLLDVRTQEDLETIDMSPVGISYSSSHFKGLSTGGNVSKAMALAGERASYNTVITYGSQLLLLGTRRLHIVFIRTWSERLRYLTLEKRFPEALALGLAFYQDKGKAVVGLSGLKKVRKRMTFIKTSQVLMQYMQELNKLPTIAASSETATTETTSNTSSSSSSSNINPSDSIFCNNNNNNNNNAENEIISTCVDYAVQLENTHLLFGPLWDLVCDNTLLKGYFLRALETPLLDGSLPPRLPPLIAQQLVALYEKEQRFESLQTIIVLLDIDCLDMHQVTTVCREKCLWEALIHLQTVALGDYTAPVHQLMPILQNYLINKDSLSRECIKLGNALLVYASCCLAGRGFPRGDLPEGQPPRAKAQILAALLSQHSSLAADSERQYPYLRTLLKFDARGFLDVISMAFQEPEFKTEMGYRQRQRLIDILLTIVVPSTPPSPQSQDYLDENKKSPVLVFIANQVANTNVTLEPGVLKQLVELLCTESLSSKIVRDQKLERENAVLQLIYTHKLNGITDNVLLTLAQRVNYYKIAEVIYTARDDWTSVCKCFIADCYRQHQVWSWLEKLSTSGFIKVVLDNIPALVGIDVDRIAGLIAKRIPGKVDKIIERLKNDPSLEYSLLLALFLINQYNDEEASKVELATQQLERLLELMCQYDPARVVGHMNGAHGCRLDQALVIVEKSGHQEALALMYEKMGNFQEAFELLSGILKKKLRDFCDGGSEEDVVAATINVSGLCRRSAGNLDWMPLVETVLKSYDLESDKNDKKDKLENLRGKLLKIVLEALSGTNALSIVLERILKHPLATSGTVGDIRQLLTGVLTHSRYEQILVEKTAKLVSLELHESLKKTLRDAGRACASACTVCPVCRQILSQCTDYTVFFGCGHGFHSQCLGETKLCYKCLTDKGWAPVATNYTPESRAPPERPPILPPMFMRRRDLTLKLGAPTVLPNLEGIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HAC6</accession>
    <name>A0A8J2HAC6_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS4012</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5084095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HAC6"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5084095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="222" mass="25276" checksum="4B91CFC49B2BB12C" modified="2022-05-25" version="1">MPKQLLLKAELKIPILKGSSRKLNFGKPYYTYCVEGTVQEFTPPLNRDSQSHITYHHCFYPHSLPERAFQIPIHSWLPFRSFQLVPGYTYVTQGILYKRLIVFDNLISVFVGHKVKVNNVASERNHYAVVKSSVILKFADTIYTVFTLLLLYVSVSSNGGSNIFVDANPAQYIILEINTDSKKELDIKSNISAPLISNDRDIEAITNPVKAIKQKTDDLQRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HAK7</accession>
    <name>A0A8J2HAK7_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">protein-serine/threonine phosphatase</fullName>
            <ecNumber evidence="3">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HICCMSTLAB_LOCUS5788</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein-tyrosine phosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="3"/>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5090899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HAK7"/>
    <dbReference type="OrthoDB" id="5779068at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030837">
        <property type="term" value="P:negative regulation of actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14513">
        <property type="entry name" value="DSP_slingshot"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.10:FF:000004">
        <property type="entry name" value="Protein phosphatase Slingshot homolog 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014876">
        <property type="entry name" value="DEK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000340">
        <property type="entry name" value="Dual-sp_phosphatase_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043587">
        <property type="entry name" value="Phosphatase_SSH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043588">
        <property type="entry name" value="SSH-N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45864:SF2">
        <property type="entry name" value="PROTEIN PHOSPHATASE SLINGSHOT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45864">
        <property type="entry name" value="SLINGSHOT PROTEIN PHOSPHATASE HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08766">
        <property type="entry name" value="DEK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00782">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23040">
        <property type="entry name" value="PH_SSH1-like_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00195">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109715">
        <property type="entry name" value="DEK C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51998">
        <property type="entry name" value="DEK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50054">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEK-C" evidence="12">
        <location>
            <begin position="72"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="10">
        <location>
            <begin position="131"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="11">
        <location>
            <begin position="193"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="52"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="278"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="400"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="431"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="596"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="731"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="828"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1022"/>
            <end position="1050"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="309"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="405"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="431"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="443"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="731"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="840"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="1022"/>
            <end position="1042"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009580"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAG5090899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="1050" mass="114597" checksum="1B82057C747FCA17" modified="2022-05-25" version="1">MWSALQTLHKVSSKAREQNYFLGGLSHDWVSYYEQRIESDRSCLNEWHAMDNLESRRPPSPDSVRHKPREREETEGVIRATLKEIMMSVDLDEVTSKYIRGRLEEDLDMDLGEFKPFIDQEMLTILGQMDAPTEIFDHVYLGSEWNASNLEELQKNGVKHILNVTREIDNFFPGMFNYLNVRVYDDEKTDLLKHWDDTFKYITKARKEGSKVLVHCKMGVSRSASVVIAYAMKAYNWDFSQAWKHVKDKRNCIKPNNNFLLQLETYQGILDAMKNKEKLQRSKSDTNLKSPTTGGAARPGRTKPESDKNSVPSQSSGTELKKSGKRPKSWSPYVEMVDNVLPALSQSLESIDKTGTEITREELLRNVQTTKLVPEHESRNVLMPCDNGQSYSVSQNQIVHLPGPDNNNTPGNKLESQGHRRRGLVLNLTNQFESGSKPSSPESDLKASPENEDTQKMDTDCLVWTEPKPGTDKNSESVQVPSINVTSATCVNLGTITATGTATCSTGIIGAATCSNGTAGTGTCSSGTVGTANYISGNTGTATYMSGTAICGSGTATCSIGTAGTGKCSTGTATYVSGTAVTATCNTGTTGTGTYSGGTVGTGTVGNSSAISGRRRTKKEGDLFSAQVDKVFDREERREPRELPSRQSSWSSYDSAVVLDNSVHSSWATLPSRNSSWGSYDMRSNPDPLGSSGLFPYDREEIPWHPGTVKRTKQKIEEGTGTKRVCTQNDDKVESTEPFQEPKETVDSPVGGIDISSTGITRQIGRLSTSAPAPSALEPELPTVALRTCRSESETSSPCVVNTPQCPSVKHHKMILENLTKPNFGKRCLSVDDSPEPPCSSSSSSSSSSSEGSRNKAGIVKNLKKEFEAKSKFEKSPEGSGDNVTDWASVKRDKIRSLPSSPVIAHNETKIRTSASVSATSIKDDDLEDLSVKVLVGKYEVKPPGSKDEVKKSEVQLRAHNLEAHPPAKAKIAPQEFARRSAPIIINSAVFLPEASAGEAPGRPPIVPSPQAVVASVVKAAKKQQQHGRTHPLTRLQVRPRHSSPVYNTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HAV3</accession>
    <name>A0A8J2HAV3_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Breast cancer anti-estrogen resistance protein 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">CRK-associated substrate</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">p130cas</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">HICCMSTLAB_LOCUS4873</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell junction</location>
            <location evidence="1">Focal adhesion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cell projection</location>
            <location evidence="2">Axon</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the CAS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5088499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HAV3"/>
    <dbReference type="OrthoDB" id="5983572at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005925">
        <property type="term" value="C:focal adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017124">
        <property type="term" value="F:SH3 domain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007169">
        <property type="term" value="P:cell surface receptor protein tyrosine kinase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd11564">
        <property type="entry name" value="FAT-like_CAS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11549">
        <property type="entry name" value="Serine_rich_CAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11844">
        <property type="entry name" value="SH3_CAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.830:FF:000001">
        <property type="entry name" value="BCAR1 scaffold protein, Cas family member"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.230:FF:000001">
        <property type="entry name" value="Breast cancer anti-estrogen resistance 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000009">
        <property type="entry name" value="Breast cancer anti-estrogen resistance 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.230">
        <property type="entry name" value="Alpha-catenin/vinculin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.830">
        <property type="entry name" value="Serine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021901">
        <property type="entry name" value="CAS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037362">
        <property type="entry name" value="CAS_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014928">
        <property type="entry name" value="Serine_rich_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038319">
        <property type="entry name" value="Serine_rich_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10654">
        <property type="entry name" value="CAS SCAFFOLDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10654:SF18">
        <property type="entry name" value="IP17195P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12026">
        <property type="entry name" value="CAS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08824">
        <property type="entry name" value="Serine_rich"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0007">Acetylation</keyword>
    <keyword evidence="8" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="9" id="KW-0965">Cell junction</keyword>
    <keyword evidence="12" id="KW-0966">Cell projection</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 16" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="11" id="KW-0729">SH3-binding</keyword>
    <keyword evidence="18" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="18">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035205572" description="Breast cancer anti-estrogen resistance protein 1" evidence="18">
        <location>
            <begin position="17"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="19">
        <location>
            <begin position="11"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="131"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="142"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="155"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="17">
        <location>
            <begin position="182"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="230"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="242"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00072413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00079691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00081467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="CAG5088499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="671" mass="73388" checksum="E3DCC9211AA348CF" modified="2022-05-25" version="1">MIKIILLLLQQKCVKARALYDNIAEAPDELAFRKGDVLTVLEQNTSGLEGWWLCALRGRQGICPGNRLRLLVGQYDTGGCLGGSRADLTLAEDGLQRHGKRRSWHVQPNRVITPQKCGDVYLYDLPVNRASPAPSSRRDSPLNSSDQLHNASRLSSGQQSSIDSGGDVSDCYDVPPRATPVIPSPASSPSPAPSCYDTPRPPTSCTPNSNCSGGSGITPLDCYDIPRPLQPLTPSSSASSLTNDGSLSGSNRSSITAPDYDIPRPRLPSNSKYNTPIHKISTTSLSSQNLHQQQRQQIYDVPVNRELPLELDSALEGLEKLQSEASAAIARLLGFVSPGWRTSQRLDSTLMDLRLAALRLRTSLHDLAEFAEGTLGNASKAPDKGLANKFRPLVKALRDSDKLVKEAAWKLDAIEWDAAKLSRNNESKISTNNSSPSFISSIHPDPLDQLIACARALTEDVRQIASFIQFKNFSTQIKKITEDDDYVNLDSRETVAKQREELRATLPQELRSSYDLLVSEADNAAIQMPPSTPTPMDPNDKQLLAFYVAQVITHGAHLTHAIDAFLQTVEHNQPPKVFLAHGKFVVLSAHRLVHIGDTVHRNVTRNDVRTKILECANSLSEALAQTVLKTKQAAQFFPSVTAVQEMVDSVVDVSHLAKDLKVAMIHAAQQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HBM5</accession>
    <name>A0A8J2HBM5_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Similar to emc7: ER membrane protein complex subunit 7 (Xenopus tropicalis)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HICCMSTLAB_LOCUS4303</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EMC7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5085197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HBM5"/>
    <dbReference type="OrthoDB" id="27095at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072546">
        <property type="term" value="C:EMC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019008">
        <property type="entry name" value="Beta_sandwich_EMC7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039163">
        <property type="entry name" value="EMC7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13605">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13605:SF4">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09430">
        <property type="entry name" value="EMC7_beta-sandw"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0732">Signal</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035234366" evidence="8">
        <location>
            <begin position="23"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="121"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="ER membrane protein complex subunit 7 beta-sandwich" evidence="9">
        <location>
            <begin position="58"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF09430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAG5085197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="193" mass="22451" checksum="B152F87B7705AC47" modified="2022-05-25" version="1">MNFINKSICLLFIFVNINCIFAESDEDLSNDLYVIEGKVFPWDGSPNGWQLMTHVMANVVNPNYAYEPVRVEINSKGKFRARKVNLIQTSQVIQVPYPLKMRAVTPFRYFQVREQWRVADFLFSPMVLMMILPLLLIMVIPKVMNDPETRKDLEQFNSLTSYNMPEMSEVITSFLTGNDKQKTKAIKATKKRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HCB3</accession>
    <name>A0A8J2HCB3_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS6884</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5093503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HCB3"/>
    <dbReference type="OrthoDB" id="7492791at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035175389" evidence="1">
        <location>
            <begin position="17"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5093503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="122" mass="12053" checksum="E6DFA55A9D672716" modified="2022-05-25" version="1">MFSLICIFSLIAAASAGIVHPAPLIAPGVPAPIVTARSSQVIARNYNTFAAAPLAYTAPAALAAPAAIAAPAAIAAPAAFAAPAAHPFAYSVPAHPFAYSLPAHPLAYTAPAVASGPLVFKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HDU4</accession>
    <name>A0A8J2HDU4_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS5530</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5090201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HDU4"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035245989" evidence="1">
        <location>
            <begin position="20"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5090201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="111" mass="12253" checksum="E4D850824B81CEEC" modified="2022-05-25" version="1">MVCLKTAIVLAVLASAVKAAEEEKTNTMKIFVHCSPTNVNVKYTPEANIAGKFYFENSTDPTCQKEFSKGAEETLMVDYETCVPDESKNFSIIVEYVNEANETKKSRGSGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HED9</accession>
    <name>A0A8J2HED9_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS6767</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5093361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HED9"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035161905" evidence="1">
        <location>
            <begin position="29"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5093361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="67" mass="7907" checksum="7423A1BA1498F9CA" modified="2022-05-25" version="1">MSMLWHTLNMGLIVILIHFNSENRKNNSDNPDQESNPDPLVTHQGLFQLNCMRHRLLAKFVKLQYFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HF53</accession>
    <name>A0A8J2HF53_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Isoform G (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS8901</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5097835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HF53"/>
    <dbReference type="OrthoDB" id="3437960at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="15"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="90"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="119"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5097835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="162" mass="19564" checksum="0C0878416E92A752" modified="2022-05-25" version="1">MNFHYRHLCGQEPRYRCPYCTLKTKRTYNIYRHIDRYHYGEKKINKARLKINKKLTKNFFLQKLGPKFPRLVAYTEEDREDAWYPGKMAYHCPRCNAGYTYKKTLKTHLKYDCGKEPRFKCPYCNKKDKCSSNIYKHVRLRHDGLPVTIRPEDGQQESQVTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HF92</accession>
    <name>A0A8J2HF92_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS8311</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5096641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HF92"/>
    <dbReference type="OrthoDB" id="415822at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5096641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="70" mass="8138" checksum="50BEBA66DFB8B621" modified="2022-05-25" version="1">MKEIAAACDASMPRLKNQSFHRPANWWSADIAELRKICHHLRRRATRAAKQSPSQDLYSIEYKQAKKTLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HFF4</accession>
    <name>A0A8J2HFF4_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Similar to Bug22: Cilia- and flagella-associated protein 20 (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HICCMSTLAB_LOCUS8770</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5097573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HFF4"/>
    <dbReference type="OrthoDB" id="7486196at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040441">
        <property type="entry name" value="CFA20/CFAP20DC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007714">
        <property type="entry name" value="CFA20_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12458">
        <property type="entry name" value="ORF PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05018">
        <property type="entry name" value="CFA20_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0966">Cell projection</keyword>
    <keyword evidence="4" id="KW-0969">Cilium</keyword>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0282">Flagellum</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CFA20" evidence="3">
        <location>
            <begin position="1"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="169"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="559"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="356"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="171"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="183"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="213"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="253"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="293"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="339"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="559"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="582"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="596"/>
            <end position="606"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG5097573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="606" mass="69530" checksum="B2F40B782A48D7A3" modified="2022-05-25" version="1">MFRDKCPKGPLSILYACGKSPLELWDMHVRNGFVRRVMDNEINSLAVEIAGTNVSTAYIYSPKNQSASLGISHPFIVILLKNMKRYFTMEITTKIRPFSTTMPMGLGCGWNQIQLNMVELVKIAYGTVYRETTRLQIHANCRIRRIYFSDRLYGEEDLSEEYKISFTKPKTNKEDKKDRRSITSKTSGNRSLNSQTSQEKAPGDRGSFNGSQKGEENPKLEVRIPITEYDEDRSEQTNRDSVIDGEFTATELSETEAGEYSDEEEGETDNGEIEETDEEEEGVDGNEEIDGDANEREELGQEEKVGEEIGQEEENKGESGDMGDVDKKEETDVEDDGENVEKIMDNLDKNESIKGVDLKEEEVNMNEKLNDEAKNELSKEEIKSEFQELNDNGKIMDNLNKNESTKEIDFKGEESNINKELNNDKKNELTKEEIKSEFEEELNDYGKIVDNLDKNESIKGVDLKKEEVNMNEKLNDEGKNELSKEEIKSEFQELNDNGKIMDNLNKNESTKEIDFKGEESNINKELNNDKKNELIKEEIKSEFEEELNDNGKIVDNLDKNESIEGIDLKGEEELNDDNENNESIKKEIKSELKGELNNNYEYQQTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HG10</accession>
    <name>A0A8J2HG10_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Olfactory receptor 33.1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HICCMSTLAB_LOCUS9244</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5099807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HG10"/>
    <dbReference type="OrthoDB" id="8185860at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005549">
        <property type="term" value="F:odorant binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004984">
        <property type="term" value="F:olfactory receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004117">
        <property type="entry name" value="7tm6_olfct_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21137">
        <property type="entry name" value="ODORANT RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21137:SF35">
        <property type="entry name" value="ODORANT RECEPTOR 19A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02949">
        <property type="entry name" value="7tm_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0552">Olfaction</keyword>
    <keyword evidence="8 11" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="9" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="24"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="54"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="239"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="267"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAG5099807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="344" mass="39643" checksum="282AB4C468857EC6" modified="2022-05-25" version="1" fragment="single">MIKKIEGLIQILNAWPINQSRKKLTMFIIYLIYETIYLSMAFNDVVSIFGNLQLMTANFLGTLVQLVMVIRLIFIRFSDKMKEIIEEIFDNCVAKNYPSKSEKEIYIKYSLKAKNFYLILFDKFEKLKKGLLNYPATLEIPYRVKLFNSNGTSYRKTILLYIFELPLPVTAISYIASINLQFVIISNICARIAILANRIKNINCNRDNKTESLIKHIVLKHVELIQLVHRVNETCTPMLFVELLIWIPLLALVLFSAIVALEANETVAFLMLFNYICAALACLFANCLMGEILLTEETFYVCKWEEMSNKSRRSWLVCMSSGANIPMQITAGKIYIFSFNGFTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HGK2</accession>
    <name>A0A8J2HGK2_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Similar to AAEL012261: Probable cytosolic Fe-S cluster assembly factor AAEL012261 (Aedes aegypti)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HICCMSTLAB_LOCUS5386</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="2">Component of the cytosolic iron-sulfur (Fe/S) protein assembly machinery. Required for maturation of extramitochondrial Fe/S proteins.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the NARF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5089817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HGK2"/>
    <dbReference type="OrthoDB" id="10253113at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.950.10">
        <property type="entry name" value="Fe-only Hydrogenase (Larger Subunit), Chain L, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050340">
        <property type="entry name" value="Cytosolic_Fe-S_CAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009016">
        <property type="entry name" value="Fe_hydrogenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004108">
        <property type="entry name" value="Fe_hydrogenase_lsu_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11615">
        <property type="entry name" value="NITRATE, FORMATE, IRON DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02906">
        <property type="entry name" value="Fe_hyd_lg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53920">
        <property type="entry name" value="Fe-only hydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Iron hydrogenase large subunit C-terminal" evidence="3">
        <location>
            <begin position="114"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00025700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG5089817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="264" mass="29955" checksum="03F3AEE14366E18B" modified="2022-05-25" version="1">MAESRFSGALQITNLDDFITPSQECIKPVEYKKKYDTGAKIKIQSKEFMEINKREPEQLEKVEITLADCLACSGCITSAESVLVSQQNQEQLLRIFEEKKTQQVASDESGNIKLIVVSFSVQPILSLAERYDLDPEDTALRLAGYFRELGADVVLDMTAADDLALLESAKEFIKRYNYQQEGLKKQIPMLASSCPGWICYAEKTHGSFILPYISNTKSPQQIMGSLVKYHLSKLKQVLPENIYHVTLMPCYDKKLEAFRDDFLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HHU6</accession>
    <name>A0A8J2HHU6_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Similar to gk5: Putative glycerol kinase 5 (Danio rerio)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HICCMSTLAB_LOCUS9156</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FGGY kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5099631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HHU6"/>
    <dbReference type="OrthoDB" id="6278781at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006071">
        <property type="term" value="P:glycerol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046167">
        <property type="term" value="P:glycerol-3-phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006641">
        <property type="term" value="P:triglyceride metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000577">
        <property type="entry name" value="Carb_kinase_FGGY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018485">
        <property type="entry name" value="FGGY_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018484">
        <property type="entry name" value="FGGY_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10196:SF68">
        <property type="entry name" value="GLYCEROL KINASE 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10196">
        <property type="entry name" value="SUGAR KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02782">
        <property type="entry name" value="FGGY_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00370">
        <property type="entry name" value="FGGY_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000538">
        <property type="entry name" value="GlpK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carbohydrate kinase FGGY N-terminal" evidence="4">
        <location>
            <begin position="3"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="Carbohydrate kinase FGGY C-terminal" evidence="5">
        <location>
            <begin position="296"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAG5099631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="439" mass="48999" checksum="D2370CD7113BBE05" modified="2022-05-25" version="1" fragment="single">MKYIVALDVGTTTIRCHILDNKAVTIASAAEKVELLYPKAAYVEINPDQLWESIIKVLKDAVHASKIDVKLIACLGISTQRSSFISWNFETGKNYHRIITWKDLRADSMVREWNSSLTMKSLRMGSHILYTLSRNKRFLAGSVLKLMNTQTTLRLMWVLQNIPGLREAAQSGKAVVDSAGDFGTIPKDILGVSIPIRCCVCIIYQNYSQDNLLSYCLLQMADQAASLFGSTCFEPGDLKVTMGTGSFLNVNTGKEPHASVAGLYPLVAWKINSEIVYMAEGASSDTGTVIEWIKSIGIIKDPRRAHIVRSVLEGLVFRILLLYESLCTETSRNYNSIRVDGGVSQSDFILQLLADLTGLPVERAMSPEISILGVAFLSGLQCGIWETREEVCKLRQVDRVFQPDIKRGKNYLSVVHQWKLAVQRFKNCIVILRSINEPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HI57</accession>
    <name>A0A8J2HI57_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similar to Tex9: Testis-expressed protein 9 (Mus musculus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS5886</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5092059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HI57"/>
    <dbReference type="OrthoDB" id="269872at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23313:SF0">
        <property type="entry name" value="TESTIS-EXPRESSED PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23313">
        <property type="entry name" value="TSEC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="64"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5092059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="157" mass="18797" checksum="1D19D668BC357ADA" modified="2022-05-25" version="1">MADDLLIKEKEFRRINKELESKTHKLLEEIDTVINNNHKNNFETEIVKFRTQSAFNFFNTEYKLNRSLEDNEKLKNSLKSSKNEERNNVNKIRKLEDHIKVITKNNERLRQELVQAFKKQSLLVDNLKKQKAYLETSRQVELTRDDFLKIIKAYIVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HI87</accession>
    <name>A0A8J2HI87_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1</fullName>
            <shortName evidence="8">Oligosaccharyl transferase subunit DAD1</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HICCMSTLAB_LOCUS9384</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the oligosaccharyltransferase (OST) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Endoplasmic reticulum membrane</location>
            <topology evidence="1 8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the DAD/OST2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5100100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HI87"/>
    <dbReference type="OrthoDB" id="445566at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008250">
        <property type="term" value="C:oligosaccharyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003038">
        <property type="entry name" value="DAD/Ost2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10705">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE SUBUNIT DAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10705:SF0">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE SUBUNIT DAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02109">
        <property type="entry name" value="DAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005588">
        <property type="entry name" value="DAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="28"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="54"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="92"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAG5100100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="111" mass="12590" checksum="D53435F95C073F18" modified="2022-05-25" version="1">MSIVAVLKKFFNEYSKSTPKKLKIIDSYLLYILLTGVIQFLYCCLVGTFPFNSFLSGFISCVSCFVLAVCLRLQVNPQNKSQFYGISPERGFADFIFAHIILHLVVMNFIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HJ80</accession>
    <name>A0A8J2HJ80_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ubiquitin-conjugating enzyme E2-18 kDa</fullName>
            <ecNumber evidence="2">2.3.2.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HICCMSTLAB_LOCUS11424</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.</text>
            <dbReference type="EC" id="2.3.2.23"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.23" evidence="2"/>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5103267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HJ80"/>
    <dbReference type="OrthoDB" id="9973183at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061631">
        <property type="term" value="F:ubiquitin conjugating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd23801">
        <property type="entry name" value="UBCc_UBE2L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000011">
        <property type="entry name" value="Ubiquitin-conjugating enzyme E2 L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 7" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="9">
        <location>
            <begin position="2"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="126"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="6">
        <location>
            <position position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00067751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAG5103267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="158" mass="18240" checksum="6A91BBAA1E57550A" modified="2022-05-25" version="1">MAATRRLQKELNDLRASAMKNFTNIQVDESNILNWQGLILPDNPPYNKGAFRIEINFPAEYPFKPPRITFKTKIYHPNVDEKGQVCLPIITAENWKPATKTDQVIQALIALVNDPEPEHPLRADLAEEFLKDKKKYLKNAEEFTKKHAEKRREPSSAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HJC8</accession>
    <name>A0A8J2HJC8_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ornithine decarboxylase antizyme</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HICCMSTLAB_LOCUS8979</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subunit">
        <text evidence="2">Interacts with ODC1 and thereby sterically blocks ODC homodimerization.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ODC antizyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5097991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HJC8"/>
    <dbReference type="OrthoDB" id="5959761at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008073">
        <property type="term" value="F:ornithine decarboxylase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045732">
        <property type="term" value="P:positive regulation of protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0075523">
        <property type="term" value="P:viral translational frameshifting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002993">
        <property type="entry name" value="ODC_AZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038581">
        <property type="entry name" value="ODC_AZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10279">
        <property type="entry name" value="ORNITHINE DECARBOXYLASE ANTIZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10279:SF10">
        <property type="entry name" value="ORNITHINE DECARBOXYLASE ANTIZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02100">
        <property type="entry name" value="ODC_AZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01337">
        <property type="entry name" value="ODC_AZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0688">Ribosomal frameshifting</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022758"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAG5097991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="179" mass="19843" checksum="A2DC1BBE0CA6637E" modified="2022-05-25" version="1">MSSWDCIVESTGYTSTWGLCGGPDAPHTALSVSAVNTESRGVGIKQSQLSVSSHIVSEDELLKAVKTNESVRLVFTLHLTETTSVEWETIIWRGTLYIRVPSCLLPEGSKEGFVSLLEYAEETLHCSNVVICLRKDRTDRAMLVRTFMFLGFTVLPPNHSLVPPNCDPGNLYMLYTVDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HJX0</accession>
    <name>A0A8J2HJX0_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Alpha-N-acetylglucosaminidase</fullName>
            <ecNumber evidence="7">3.2.1.50</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HICCMSTLAB_LOCUS11625</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>Hydrolysis of terminal non-reducing N-acetyl-D-glucosamine residues in N-acetyl-alpha-D-glucosaminides.</text>
            <dbReference type="EC" id="3.2.1.50"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the glycosyl hydrolase 89 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.50" evidence="7"/>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5103669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HJX0"/>
    <dbReference type="OrthoDB" id="64736at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004561">
        <property type="term" value="F:alpha-N-acetylglucosaminidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048731">
        <property type="term" value="P:system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000107">
        <property type="entry name" value="Alpha-N-acetylglucosaminidase family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.379.10">
        <property type="entry name" value="Chitobiase/beta-hexosaminidase domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.670">
        <property type="entry name" value="N-acetyl-b-d-glucoasminidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029018">
        <property type="entry name" value="Hex-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007781">
        <property type="entry name" value="NAGLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024732">
        <property type="entry name" value="NAGLU_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024240">
        <property type="entry name" value="NAGLU_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024733">
        <property type="entry name" value="NAGLU_tim-barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12872">
        <property type="entry name" value="ALPHA-N-ACETYLGLUCOSAMINIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12872:SF1">
        <property type="entry name" value="ALPHA-N-ACETYLGLUCOSAMINIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05089">
        <property type="entry name" value="NAGLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12972">
        <property type="entry name" value="NAGLU_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12971">
        <property type="entry name" value="NAGLU_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035269340" description="Alpha-N-acetylglucosaminidase" evidence="9">
        <location>
            <begin position="22"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-N-acetylglucosaminidase N-terminal" evidence="11">
        <location>
            <begin position="48"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-N-acetylglucosaminidase tim-barrel" evidence="10">
        <location>
            <begin position="145"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-N-acetylglucosaminidase C-terminal" evidence="12">
        <location>
            <begin position="488"/>
            <end position="745"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00052030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00060996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00066522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00072202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF05089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF12971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF12972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAG5103669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="775" mass="90305" checksum="96FAE84A41EEA564" modified="2022-05-25" version="1">MMVNTALYFIIISVLYSGSSGHHNHINNFESTLGHLKPRSLPAVQAEAALMLIERTIGEKVSHFSVSVDPNLGPIGKDTFEIKKGSSEYQEIFITGTSGVAVTWGFHHYLKKHCNCQIAWEGEQIELPDILPDVNERITSNDRFRYYQNVCTTGYSSAWWGWDQWEKNIDWMALNGINLALAFHGQEAIWERVYLKMNLTSQEINQHFGGPAFLPWSRMGNIRGWGGLLSSSWHNHTIVLQHRILNRMRELGIIPVLPAFAGHVPRAFSRIYPHANMTKIGVWNQFDDQYCCPYLVSPTDPLFKIIGQKFLHEYINEFGTDHIYNCDTFNENEPVDTDTESLKMIGQAIYSAMTDVDPQAIWMMQGWLFVHEFDFWTESRVEAFITSVPLGKMIILDLQSEQFPQYMRFKSYFGQPFIWCMLHNFGGTLGMFGSARIISERVIEARNMEGSTMIGTGLTPEGINQNYVIYELMNEMAYRREPVNLDKWFENYSVRRYGGRNEYASQTWNILGKTIYNFIGLERIRGHYVITMRPKGNIKTWWWYDPELIIEAWGIFLNARNEKANKSLYRHDVVDITRQALQLIADEIYLSIKNAYAKNNSTLLRQQSELLVELFDDLERILDSSENFRLGKWLEAAKLLGTNEKERELYEYNARNQITLWGPNGEICDYANKQWAGVIVDYFKPRWVIFLKALQESVETKQILNQTLINQLIFEQVENPFTFSHKNYPVEPQGDSVLIAVELNNKWKNYKLHFIERKILRYERRMIVNKKTILT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HK64</accession>
    <name>A0A8J2HK64_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cc_vp91</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS9038</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5099387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HK64"/>
    <dbReference type="OrthoDB" id="7699702at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="497"/>
            <end position="519"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5099387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="845" mass="99527" checksum="1DF871ED09E8AF97" modified="2022-05-25" version="1">MRTIYEIICGIIFVLLNITLVSVVYYYNRHPIKKYGGKKLKPEELSKVIAKEIGNQPQYYTYQQKDKGKYSVYVLSHTDNLTYQEKEFNYPVDFDGVPAKLMLESNFKLTYEEEGFKVRGIKQSFTCPKDYKWDIKLNKCIEKPICNYYNDSVIRLYDRYYSEIDNPSITPITILTGENPHPRLYIRCSSLQQKPIIEACYKENEQVNENAFKDVTDYNNNNNNNNNNNNSIIKPCELYDICKNYPDGTRHAYRINNIFSQALKINEYYKCIGTKSKKFHCQQGYECNELSIHNNDICKPIDDCRPNIDYYFTTNPHSFYHCLSNKRKIECCGENGIIKLSDNSYQCKKDDKYVYYSDDNVAKQTTINGFKYKSELTKGLQKTKLSRVSFDNWFYEKFPQLFEKFSYLSLPTTQIKINENDRQFTYYNNTNNLREFYENLNDIKLPNKFHYILTKDNREKWTLITKKELSESPNNIIDFSSKIIHLSASNLMTEISSTIKSPPDPDHNNDNDDDEISSSAKNVNDYYDIKIISNDYGLKGVDFWIIFNGNIYKYINETSNTEKLNLSSREYYSFIGVKTTAPKKISDDHDIKIIGKAFREVEGIYYALCLKYDDNKFKFNNNQFICHIDLKTLSITDKDITSKLSIDLERLKKDGVLPDQSKILDEFTWDKLYVGKYYYDHESKKLIVWHHHLFVLKLQNFIIKKLEDEKKGNKLNFDNNGQFIYNNYPTNIVDVTYNNISQDNSIYKTTNKYLTALATTFSYYNYNYEKPVVHWSLYIPINPVCFLITQQKIDSPDNTPDETTLYRGQSILNYLTIEYPKVKKSTEIETLLNIIQLNQLTLTLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HLJ5</accession>
    <name>A0A8J2HLJ5_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Mitochondrial (Rattus norvegicus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS10056</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5100983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HLJ5"/>
    <dbReference type="OrthoDB" id="7249367at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032979">
        <property type="term" value="P:protein insertion into mitochondrial inner membrane from matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007379">
        <property type="entry name" value="Tim44-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13333">
        <property type="entry name" value="M-AAA PROTEASE-INTERACTING PROTEIN 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13333:SF5">
        <property type="entry name" value="M-AAA PROTEASE-INTERACTING PROTEIN 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04280">
        <property type="entry name" value="Tim44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tim44-like" evidence="1">
        <location>
            <begin position="107"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5100983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="192" mass="22019" checksum="4C924BA980F139D2" modified="2022-05-25" version="1">MLLNNICKNVCNNPRLRYYGVLAANKIKKLESNKLPNFSCLQEKRMIDSVIKTTNCGEKRFYSALPNEELNPPVRLSALTDDPLILMPSFFKSIKSSYNLHFVMQSQIDKEFDMHEFADGSKQAVEMVSHTLAAEDYDSLQGLVTPDVIQKLRYKISTLSEAQKQLIPVKKEEIYGMFPYTIDIVEKDCLLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HLL2</accession>
    <name>A0A8J2HLL2_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Similar to psmg3: Proteasome assembly chaperone 3 (Nematostella vectensis)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS10086</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5101013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HLL2"/>
    <dbReference type="OrthoDB" id="5839at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000502">
        <property type="term" value="C:proteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043248">
        <property type="term" value="P:proteasome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018788">
        <property type="entry name" value="Proteasome_assmbl_chp_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053720">
        <property type="entry name" value="Psm_Assembly_Chaperone"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31051">
        <property type="entry name" value="PROTEASOME ASSEMBLY CHAPERONE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31051:SF1">
        <property type="entry name" value="PROTEASOME ASSEMBLY CHAPERONE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10178">
        <property type="entry name" value="PAC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0647">Proteasome</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5101013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="113" mass="12766" checksum="7583CECBD2B46A09" modified="2022-05-25" version="1">MSNNDCGILINGNHTDIAVKVYKNRLFIIVTQFQKFGSMVTVTRESSLDQFNSDTYSTHVIFGKDTEEVHAAVRYIAEAINIDRPLLLSIALKDYELSTLKVIVSTINKLKAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HM10</accession>
    <name>A0A8J2HM10_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Similar to AVPR1A: Vasopressin V1a receptor (Homo sapiens)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HICCMSTLAB_LOCUS12410</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Cell membrane</location>
            <topology evidence="1 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5106738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HM10"/>
    <dbReference type="OrthoDB" id="6435638at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042277">
        <property type="term" value="F:peptide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005000">
        <property type="term" value="F:vasopressin receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032870">
        <property type="term" value="P:cellular response to hormone stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15196">
        <property type="entry name" value="7tmA_Vasopressin_Oxytocin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001817">
        <property type="entry name" value="Vasoprsn_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24241:SF161">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24241">
        <property type="entry name" value="NEUROPEPTIDE RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00896">
        <property type="entry name" value="VASOPRESSINR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 10" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="8 10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 10 12" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 10" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="139"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="184"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="252"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="285"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="11">
        <location>
            <begin position="33"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU046427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAG5106738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="384" mass="44772" checksum="7081CFEA8C1A7AA0" modified="2022-05-25" version="1">MMDNSTSLDTRDENLAFWEIIVLVINLIITLIGNCFIFFALYLRRYHGRQRKLTRMYFFMMHLSIADFITGIFNILPQLSWDITFRFQGGPAMCKIVKFLQPFGNYLSSYVLTATAIDRYQAICNPFSYCRTSSLKSRVMVYSAWVLAFILCIPQVFVFSYQKISTGVWDCWASFSLPYGERAYVTWYSISVFLLPFIVLFYTYAKICLDIRKNTEISQRFDHVNDTKRMNLNHKNRQPLISRAKIKTIKQMITVVSLYIITSSPFIGCQLWATWDPQAANSPFINGPIFTILTLMSSLTSCVNPWIYLWFNRELRIILLSYLKKIICNQNMISYDNDPSYNSNGSSTKSSIIVTMFRCAGSIYHRQTSQERSTVDFILIRRES</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HMH2</accession>
    <name>A0A8J2HMH2_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cc_odve66_10</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS10729</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5101866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HMH2"/>
    <dbReference type="OrthoDB" id="7688071at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5101866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="278" mass="32305" checksum="298DAEBBB6295A53" modified="2022-05-25" version="1">MKSTQIAIIVVAAVLSILYMVGVIALGLHLMHKSMEKKLIAKISYVKNKLGYLAVTNISKTDEDKFNSFQADFSTSTDWHDNPSELINLCNFATLLIKYYNLKPDDKTSKEYLKLANDILKKLNERIFKPKDYSTLVKSNSCELLSTLLILLNTFDYLADETYQSTKTICHKQILEMVPEFNKIRLGGVPESNLNRFYKDYNVIYTITARLLTNIKHNRSVYQYDVEQKEVIQILKTQFDYLSKTPEEKNKFHLYEVYYSVYQILSNDAFTSYEKLAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HMJ4</accession>
    <name>A0A8J2HMJ4_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS11712</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5103843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HMJ4"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5103843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="64" mass="7547" checksum="2DB386594983AD74" modified="2022-05-25" version="1">MCQDLLLNKDCKFLSTLSTFKFLLSKLLFESRELNIFADEFKVKFKRLSSVGRVSHNHDFSPEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HMV8</accession>
    <name>A0A8J2HMV8_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS11924</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5104282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HMV8"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5104282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="123" mass="13338" checksum="524A2EC71015316D" modified="2022-05-25" version="1">MVIPSAMPVMLFALRSNKSNLYKEPLPETGSPSFSPIVPAHSLPAGSTFASLNLVSLTPTSTWLINFTLGSKSSVAGSQDTWIKFVPHAVMKVFFLLATGIANPTDPHSSSEEKSIFYRIILR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HNQ4</accession>
    <name>A0A8J2HNQ4_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="16">CYP6AQ22</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">HICCMSTLAB_LOCUS11807</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Microsome membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5104047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HNQ4"/>
    <dbReference type="OrthoDB" id="2789670at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11056">
        <property type="entry name" value="CYP6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000042">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050476">
        <property type="entry name" value="Insect_CytP450_Detox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24292">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24292:SF45">
        <property type="entry name" value="CYTOCHROME P450 6G1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 13 14" id="KW-0349">Heme</keyword>
    <keyword evidence="10 13 14" id="KW-0408">Iron</keyword>
    <keyword evidence="12 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 13 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0492">Microsome</keyword>
    <keyword evidence="11 14" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="9 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="15"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="13">
        <location>
            <position position="461"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CAG5104047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="517" mass="59668" checksum="8088211A518082C3" modified="2022-05-25" version="1">MIDYKIVTMAFFTKYWMLDILIIVFGLTVAAYLYMTRKFKYWKKLGVVEIPPTAFVGNYGECLMSKKNPGEWLKEIYDEGSGLPYIGFYVFDRPFFLVRNPKLVKQVLVKDFNCFNDRFLTASPHDSIGDANLFSIKNPRWKLLRSKLTPIYTSGRLKKMFELMTVVGDELEAFMESLNFEEKGKTLELKDLCARFTTDLISTTAFGIKTNCLKYPDAEFRKKGRRMFETTMIRNFEISTLFFAPQFATPCRIKFVPEENTKFFRKTVWDVIAERERSGETRGDFIDLLMELRKNKAKVFEDKLDFDGDMLVAQTIVFFNAGFEPTSSSLSFTLYELALQPEIQDRVRAEIVEGLEGTDGKVTYNLITSLPYLDMVIAETLRMYPTLPFLDRVPNQNYQVPDSDLVLEKGTPVLISVRGLHFDPQYFPNPEKYNPERFSETNKKMIPPCTYLPFGDGPHNCIGMRIGLLQVKLGLIKLLSKYEFTPCEETLIPMRLSPKALFIVSEGGVYLNVKKIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HNX8</accession>
    <name>A0A8J2HNX8_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Similar to Lrp2: Low-density lipoprotein receptor-related protein 2 (Rattus norvegicus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HICCMSTLAB_LOCUS10955</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5102318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HNX8"/>
    <dbReference type="OrthoDB" id="7635222at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00112">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.400.10">
        <property type="entry name" value="Low-density Lipoprotein Receptor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036055">
        <property type="entry name" value="LDL_receptor-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051221">
        <property type="entry name" value="LDLR-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023415">
        <property type="entry name" value="LDLR_class-A_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002172">
        <property type="entry name" value="LDrepeatLR_classA_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22722">
        <property type="entry name" value="LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00057">
        <property type="entry name" value="Ldl_recept_a"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00261">
        <property type="entry name" value="LDLRECEPTOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00192">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57424">
        <property type="entry name" value="LDL receptor-like module"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01209">
        <property type="entry name" value="LDLRA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50068">
        <property type="entry name" value="LDLRA_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 10" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="57"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="69"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="124"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="144"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="151"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="163"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAG5102318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="218" mass="24175" checksum="A1FBC691DFC2568D" modified="2022-05-25" version="1" fragment="single">TVDIGSTYPHENEIRQILEDQLHFHALGNIQTEPTGFTFRSIQDTAPECVEPTSLKCRDGSCIQLNYRCDGIAQCPDQSDELDCPISSGFPTNESRNGFTNNCRGDDTVRCSDGSRDICSVQLCDGVPDCDDQGDENNCGGPSCSENEFSCDVSRCILDKDRCNFIQDCEDGSDERGCKYPGESVMVIIFNSQLYFYSIVLYCLLRKNLSCCDILSAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HPA7</accession>
    <name>A0A8J2HPA7_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transmembrane protein 186</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HICCMSTLAB_LOCUS10259</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM186 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5101186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HPA7"/>
    <dbReference type="OrthoDB" id="6147888at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026571">
        <property type="entry name" value="Tmem186"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13603">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 186"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13603:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 186"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="71"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="97"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAG5101186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="200" mass="22529" checksum="BF66A35E672F1441" modified="2022-05-25" version="1">MSLLSATCRRINAYRHLVCTSVSPLSIARTLSTAPQNTYDSKKFAGYKVLYNLETIKNISILNRLKYRMTIAAAVIVPGCSALDSLGFLSADFSQPLSFLTIAITFFFHGVGLFCNNVIGYIYFKPKSDDLKISYVNYWGKRIDIDADAKTVKCTENSSLLYRPVFNTVTTESTKAKLRLYVKGKVMDEKYFDNIFGIPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HPI8</accession>
    <name>A0A8J2HPI8_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DNA polymerase subunit gamma-1</fullName>
            <ecNumber evidence="4">2.7.7.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Mitochondrial DNA polymerase catalytic subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">HICCMSTLAB_LOCUS11870</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion matrix</location>
            <location evidence="2">Mitochondrion nucleoid</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DNA polymerase type-A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="4"/>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5104174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HPI8"/>
    <dbReference type="OrthoDB" id="5588663at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005760">
        <property type="term" value="C:gamma DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042645">
        <property type="term" value="C:mitochondrial nucleoid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006264">
        <property type="term" value="P:mitochondrial DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.20:FF:000024">
        <property type="entry name" value="DNA polymerase gamma, catalytic subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.390">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019760">
        <property type="entry name" value="DNA-dir_DNA_pol_A_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002297">
        <property type="entry name" value="DNA-dir_DNA_pol_A_mt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001098">
        <property type="entry name" value="DNA-dir_DNA_pol_A_palm_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041336">
        <property type="entry name" value="DNApol_Exo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10267">
        <property type="entry name" value="DNA POLYMERASE SUBUNIT GAMMA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10267:SF0">
        <property type="entry name" value="DNA POLYMERASE SUBUNIT GAMMA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00476">
        <property type="entry name" value="DNA_pol_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18136">
        <property type="entry name" value="DNApol_Exo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00867">
        <property type="entry name" value="DNAPOLG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00482">
        <property type="entry name" value="POLAc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00447">
        <property type="entry name" value="DNA_POLYMERASE_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0235">DNA replication</keyword>
    <keyword evidence="11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="13" id="KW-1135">Mitochondrion nucleoid</keyword>
    <keyword evidence="7" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DNA-directed DNA polymerase family A palm" evidence="16">
        <location>
            <begin position="844"/>
            <end position="1102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="84"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="84"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="99"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00015350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00031966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CAG5104174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="1206" mass="137384" checksum="53C02BBDA4D334F5" modified="2022-05-25" version="1">MRLKVKLINICIRHKCSKPSINGLTKLQPKFSLRKIKVKKSAKPINTELTSPASRDLNIKAIIHPEDEYQQFCAGNFNNKKNKDKIIDSRQLKDKKSASADNSENQRNNCEERFNELNMQMLPRKLHSQVFKKANNVELSREKLSELRKQLKAFGMKINDTSRIPSADIDLPPLEGEDLEEHFYKIAETQARPYFKIVEEMLRKIPEMPTSWKLQEGWTRYTTDKVEKVDYPLEPGIIFDVEVCMKEGPLPTLATAVTSEAWYGWVSKPLVDGTSLPIESRSFTLDMLVPLESTSLEFGKKLTDHQKKPKIIVGHNVCYDRARIKEQYWLNPTSTRFIDTMSLHIAISGMNSYQRALMLAKKDLLDHEELQGTSLNNLADVYKLYCGKTHEKSMRDLFVEGSLLEVRKEFDKLMNYCARDVVVTHEILEKLFPIFKERFPHPVSFAGMLELGTAYLPVNTNWTRYIEESEVAFEDLNYEAKVSLAKRADEVCKLMHGDKYKEDLWMWDQDWSTQAVKIKKKPSKIISSPGIIGEEKEISDEEKYLTDGEEEIDELEKEFGYLKESKNLLPAKLPHMPGYPAWYRKLCMKPNEENWTFGPKNISTSMKITPKLLSLTWENYPLHYIKEHGWGFLVPFNSEDVETQLPLKQLLAQCPLPIKHQQSSDTSYAMATLQAEVQKDLHKTEFWRNRKTKSDVKKSMPGIFYKGAGIWCDVIIDNCCWFFKLPHKDGPKLNVGNPLAKDFLNKFSENVLAGLDSSAREVLKISKMVSYWRNNRDRIMSQLVVWLSDSDLPGIIRRTGSSSALSRQNYGAIIPQVVVSGTLTRRATEATWMTASNAHEDRVGSELRAMVQAPPGYSIVGADVDSQELWIASLIGDAYCAGIHGATPFGWMTLIGNKSDGTDMHSVTAKAVGISRDHAKVINYARIYGAGQKFAERLLKQFNPAMSDGEALGKSRKMFSITKGKKVFKLREEFVNEELQDEDYSGFDASRVAKLHGKTVQAMFESKWEGGSESAMFNRLEEIAGSKHPVTPFLNSRLSRALEVEDELKDKYLPTKINWVVQSGAVDFLHLMLVCMRWLMRDNARFCLSFHDEIRYLVPGRYKYNAALAMHVTNLLTRSFCASRLGIQDLPASVAFFAAVEVDTVLRKEASSDCKTPSNPYGLESRYGVAKGESLDVWKAVDKAEGSLGPWHNALIRKNKVDNQLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HPN6</accession>
    <name>A0A8J2HPN6_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Similar to Litaf: Lipopolysaccharide-induced tumor necrosis factor-alpha factor homolog (Mus musculus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HICCMSTLAB_LOCUS11761</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endosome membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Late endosome membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Lysosome membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
            <orientation evidence="3">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the CDIP1/LITAF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5103941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HPN6"/>
    <dbReference type="OrthoDB" id="4713066at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006629">
        <property type="entry name" value="LITAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037519">
        <property type="entry name" value="LITAF_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23292:SF6">
        <property type="entry name" value="FI16602P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23292">
        <property type="entry name" value="LIPOPOLYSACCHARIDE-INDUCED TUMOR NECROSIS FACTOR-ALPHA FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10601">
        <property type="entry name" value="zf-LITAF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00714">
        <property type="entry name" value="LITAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51837">
        <property type="entry name" value="LITAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="LITAF" evidence="9">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAG5103941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="78" mass="8392" checksum="43C9F9AD2288A6BD" modified="2022-05-25" version="1">MYKNGPPPSYDEPPPSAPPSYFQSVGGVPPASPFTPAPTLDQPLCFLGCCLIPCCIDECMDVHHTCPNCKAYLGRHGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HQP9</accession>
    <name>A0A8J2HQP9_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Similar to msl1l1: Male-specific lethal 1-like 1 (Danio rerio)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HICCMSTLAB_LOCUS11440</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5103299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HQP9"/>
    <dbReference type="OrthoDB" id="6022555at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072487">
        <property type="term" value="C:MSL complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026711">
        <property type="entry name" value="Msl-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029332">
        <property type="entry name" value="PEHE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21656:SF2">
        <property type="entry name" value="MALE-SPECIFIC LETHAL 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21656">
        <property type="entry name" value="MALE-SPECIFIC LETHAL-1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15275">
        <property type="entry name" value="PEHE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01300">
        <property type="entry name" value="PEHE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52052">
        <property type="entry name" value="PEHE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PEHE" evidence="3">
        <location>
            <begin position="528"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="70"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="428"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="651"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="295"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="77"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="457"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="475"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="662"/>
            <end position="680"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS52052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG5103299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="680" mass="74235" checksum="20C560DBD4A9CDAA" modified="2022-05-25" version="1">MSNVSPSSQLLINGDNDVVVAGNYQEFHVLDTNRLDISGISVASDLGAIVEGVTSTSASSVVVVDYHNHPELQNTPSSTSTSSSSSSSSSCSSSSSSTSLLSLADQNILQPGAVVVVNCVGSEGTGTATGVAVSEGDGDGETGNINNNNNNNNIGIDIDSNNLNNSDINNSGSSAATAAYNMVAAMNEHLSSSSATNSARSTSAQNEFIITSGHAATDNVEDIVGDKPTSAGILTFPCDFDHMYASMTDGGTPAVAATATSTLGVSPLRGNEPRLNDLAEVKHLKELLLLHLDLIQQQSEQIVTKDKLLAALRQENETLKLRLERMDRRVNLQKLRSESTENSIASDIGPCSPPSLHSVNIVTPLIVNEQHHKNISAECNSPQYNESFKIRLNTSGGITTVKQEHTNDNLNKLDIKPDVNVAGGGDARLEWESKRNKRKSDPTPLPSSGSKRKRGVSCSSTISNDTTSTIPEGKNSTHDLSNRKSDKKGKSIIKKESFLTTEEHYYTAMGDPHYNLRTKPELEDDSNNLEVPSWRIKVYTSCYTMEGTENLDDEIFNKRHLKLENDERRRKRWDVQRIREQRHIEKLKQRQERQNHQATCYNTNHTGPCPSSTEEEVITTLWPDVDQVQSLQVDPELPVSAFGAPIPSFTPSEFSLPWLHSARSKSRRPKRSTGRRKSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HR07</accession>
    <name>A0A8J2HR07_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">UPAR/Ly6 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HICCMSTLAB_LOCUS12988</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5107939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HR07"/>
    <dbReference type="OrthoDB" id="7656257at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00117">
        <property type="entry name" value="TFP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.60.10">
        <property type="entry name" value="CD59"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016054">
        <property type="entry name" value="LY6_UPA_recep-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050975">
        <property type="entry name" value="Sleep_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045860">
        <property type="entry name" value="Snake_toxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33562">
        <property type="entry name" value="ATILLA, ISOFORM B-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00021">
        <property type="entry name" value="UPAR_LY6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57302">
        <property type="entry name" value="Snake toxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035234369" description="UPAR/Ly6 domain-containing protein" evidence="9">
        <location>
            <begin position="20"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="99"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="UPAR/Ly6" evidence="10">
        <location>
            <begin position="20"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAG5107939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="123" mass="13699" checksum="8D73933A56D7DF43" modified="2022-05-25" version="1">MKYLIFFGVIAAVFVSGQCLKCFECYGDKCDDGSSLKKEVNCTGSDQICFKQIINEYADKKVQYKRGCFAVDKIGEKFNLTNTISTEVYFCNKDKCNGVGSFTGSLSIVLVTLVALMFASEKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HR81</accession>
    <name>A0A8J2HR81_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Similar to Apmap: Adipocyte plasma membrane-associated protein (Rattus norvegicus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HICCMSTLAB_LOCUS13110</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the strictosidine synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5108183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HR81"/>
    <dbReference type="OrthoDB" id="5307922at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018119">
        <property type="entry name" value="Strictosidine_synth_cons-reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10426:SF88">
        <property type="entry name" value="ADIPOCYTE PLASMA MEMBRANE-ASSOCIATED PROTEIN HEMOMUCIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10426">
        <property type="entry name" value="STRICTOSIDINE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03088">
        <property type="entry name" value="Str_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63829">
        <property type="entry name" value="Calcium-dependent phosphotriesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="domain" description="Strictosidine synthase conserved region" evidence="5">
        <location>
            <begin position="164"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAG5108183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="427" mass="48626" checksum="B8A6A50010750475" modified="2022-05-25" version="1">MGALKCITINLLWICIILMAITFLPGLPPNIEFTSYTFKLPNYPHSYTVSNLSKAEKVFKGKIVGPESFDAYDGILYISMYGGTVSRLIDNNLEQLVKFGKSCDHSWEEDICGRPLGLKFDDNGNLYVVDTYYGIFKVNITTKRYEKIVDITIPIDGKVPMIPNSIDVAKNGDLYWTDSSSDYKLYDGIFSMLSNPSGRLIHFSAKTKKNTVLLENLGFANGIKLSDDESFIFVAETLTSRIIKYHLKGLKAGKSEIIIEGLPGLPDNIHSDNHGNFFVSLIVIADEENPQLLQSLSPHPYIRKLFVRLLTLLELPFKFFYKIYSNDCFKKFYLWIGHFQSFSFLMPRSAIVLRINEHGKILDILESRSGDISDISSAFILNDYLWLGSPFNDYLGKISMNQIFPILEKQNIKFEEKNLLDNNTKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HR82</accession>
    <name>A0A8J2HR82_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Similar to U2af38: Splicing factor U2af 38 kDa subunit (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">HICCMSTLAB_LOCUS13427</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the splicing factor SR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5108791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HR82"/>
    <dbReference type="OrthoDB" id="423462at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0089701">
        <property type="term" value="C:U2AF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12538">
        <property type="entry name" value="RRM_U2AF35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000055">
        <property type="entry name" value="Splicing factor U2AF 35 kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003954">
        <property type="entry name" value="RRM_euk-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009145">
        <property type="entry name" value="U2AF_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12620">
        <property type="entry name" value="U2 SNRNP AUXILIARY FACTOR, SMALL SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00642">
        <property type="entry name" value="zf-CCCH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01848">
        <property type="entry name" value="U2AUXFACTOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00361">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="9" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="8 11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="7 12" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="15">
        <location>
            <begin position="12"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="14">
        <location>
            <begin position="49"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="15">
        <location>
            <begin position="151"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="12">
        <location>
            <begin position="12"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="12">
        <location>
            <begin position="151"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="188"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="188"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="229"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CAG5108791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="242" mass="28326" checksum="D5DBBD76B46E6DFE" modified="2022-05-25" version="1">MAEYLASIFGTEKDKVNCSFYFKIGACRHGDRCSRIHNKPTFSQTCLLQNLYVNPQNSAKSADGSHLVANVSDEEMQEHYDNFFEDVFVECEDKYGEIEEMNVCDNLGDHLVGNVYIKFRREEDAEKAVSNLNNRWFGGRPVYAELSPVTDFREACCRQYEMGECTRSGFCNFMHLKPISRELRRYLYSRRKGGKGRSRSRSKSRGRERKRRSRSRERRSRSKERRKGGRDEKGRDGRSGRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HRA6</accession>
    <name>A0A8J2HRA6_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Similar to NR2E3: Photoreceptor-specific nuclear receptor (Homo sapiens)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HICCMSTLAB_LOCUS13473</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5108837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HRA6"/>
    <dbReference type="OrthoDB" id="5873264at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.565.10:FF:000038">
        <property type="entry name" value="Dissatisfaction, isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.565.10">
        <property type="entry name" value="Retinoid X Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035500">
        <property type="entry name" value="NHR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000536">
        <property type="entry name" value="Nucl_hrmn_rcpt_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050274">
        <property type="entry name" value="Nuclear_hormone_rcpt_NR2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001723">
        <property type="entry name" value="Nuclear_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24083">
        <property type="entry name" value="NUCLEAR HORMONE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00104">
        <property type="entry name" value="Hormone_recep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01282">
        <property type="entry name" value="COUPTNFACTOR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00398">
        <property type="entry name" value="STRDHORMONER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00430">
        <property type="entry name" value="HOLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48508">
        <property type="entry name" value="Nuclear receptor ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51843">
        <property type="entry name" value="NR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0675">Receptor</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="NR LBD" evidence="4">
        <location>
            <begin position="95"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAG5108837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="340" mass="39498" checksum="7EC71E774A594739" modified="2022-05-25" version="1" fragment="single">RQVGLRNRRDRPSHLFPIHSDNPLRRLRYVPFPQVASLMQKPPPSDATSPVSFPLQLPPPNPGLYHSATVALGQQPPLFQILMSAEKCQEFVWDTRLQPDETLDRLETEASHSPTRPLPNFSPTWEILQETTARLLFMAVKWVRCLVPFQTLFKDDQLGLLQQTWTQLFLLHLAQWSVSWDITALLDDEQVRRRLPDETSRQELNTIQDIMSRFRQLSPDGGECGCMKAIVLFRPETKGLTDPKPVEMLQDQAQCILNDYIRSRYPRQPERFGRFLLSLPMLHVVKPSTVELLFFRETIGEIPIARLLGDMYQMDHHSEEYKQDPDFSMMNLQKATDLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HS43</accession>
    <name>A0A8J2HS43_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS13441</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5108805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HS43"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81995">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5108805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="137" mass="15897" checksum="5A643465D55C542E" modified="2022-05-25" version="1">MHQQHHTVNVLTHHQINQHHLQQQQQQQQQQQQQQQQQQQQQQRHNHYQQQQQQQQQQQQQQHFDYMLMLMLMMVMITGQRKVLADFTSRVRMFSSEDQYARDCGVRSLCKATTGAGAGAGVDFGLGIAATTRGGCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HTG1</accession>
    <name>A0A8J2HTG1_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS13087</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5108137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HTG1"/>
    <dbReference type="OrthoDB" id="7628309at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5108137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="91" mass="10872" checksum="22B3060C615812E1" modified="2022-05-25" version="1">MRPVCVYLTVYDDYAVIDNSMNLLNYSERKLREDFEDVFVFKKKCDVTIHFISIAHSSVFEAMFSYNMKENKQNKVTQLDTCTQFFKKVFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HU45</accession>
    <name>A0A8J2HU45_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Similar to spz4: Protein spaetzle 4 (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HICCMSTLAB_LOCUS13602</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subunit">
        <text evidence="1">Homodimer; disulfide-linked.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5108966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HU45"/>
    <dbReference type="OrthoDB" id="6630583at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008083">
        <property type="term" value="F:growth factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005121">
        <property type="term" value="F:Toll binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0021556">
        <property type="term" value="P:central nervous system formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045087">
        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.90.10:FF:000018">
        <property type="entry name" value="Spatzle 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.90.10">
        <property type="entry name" value="Cystine-knot cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029034">
        <property type="entry name" value="Cystine-knot_cytokine"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032104">
        <property type="entry name" value="Spaetzle"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052444">
        <property type="entry name" value="Spz/Toll_ligand-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23199">
        <property type="entry name" value="NEUROTROPHIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23199:SF13">
        <property type="entry name" value="PROTEIN SPAETZLE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16077">
        <property type="entry name" value="Spaetzle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57501">
        <property type="entry name" value="Cystine-knot cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Spaetzle" evidence="6">
        <location>
            <begin position="400"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="75"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="167"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="327"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="499"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="80"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="168"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="499"/>
            <end position="513"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF16077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAG5108966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="521" mass="58986" checksum="F1D67BCFD7637F2D" modified="2022-05-25" version="1">MSLANFSLPFPVATPSPYLYTPSISQSVNNLPFNGVLPSPNFNEQSNYQNQPYLPPAYQRQHYPVQSQNPRRTQYYNTINNNNNNNNNNNNNNNHHHHHNDNNNKQRQYQVQTTQNYLSQDNNFDDYEQDYPVTQSSIRESENKNNPQHEIRPPLLEINQEDRIANRNAPSNQPQDLNNPQPDGYTKVNSYGSSGAKTSVHAVLDYDDDGDETNSNDEYYDENIPRDPRVTPIQGPIYVKNGSVPVVPLYSYQQYNNGSFLQIPILWTALSVALGVELHGDVVKGTPCIKKYHQLFCPTAGKTYPKERIELFIDENKALMKRMYGDFETDKDHGPGTSSSAKRRKRRSFDPDLPDGGPSLGRKNIEDSKYVRGGDSYFEHIRNPRQLPKNNHSDSGRLDVCESKTEVVTPYWASNSAGKIRAVVNTQHFEQAIHQEVCSKTQTNRCTGGCGCEQKYKWHRLLAYDPDDDCKGIFMDWFLFPSCCVCRCDPHAKFPGTGTATGTGTTTSSSSSTKAMTNRSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2ME16</accession>
    <name>A0A8J2ME16_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Poly [ADP-ribose] polymerase</fullName>
            <shortName evidence="5">PARP</shortName>
            <ecNumber evidence="5">2.4.2.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HICCMSTLAB_LOCUS4111</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>NAD(+) + (ADP-D-ribosyl)n-acceptor = nicotinamide + (ADP-D-ribosyl)n+1-acceptor + H(+).</text>
            <dbReference type="EC" id="2.4.2.30"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.-" evidence="5"/>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5084465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2ME16"/>
    <dbReference type="OrthoDB" id="429950at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003950">
        <property type="term" value="F:NAD+ poly-ADP-ribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990404">
        <property type="term" value="F:NAD+-protein mono-ADP-ribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006302">
        <property type="term" value="P:double-strand break repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070212">
        <property type="term" value="P:protein poly-ADP-ribosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.228.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050800">
        <property type="entry name" value="ARTD/PARP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012317">
        <property type="entry name" value="Poly(ADP-ribose)pol_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10459">
        <property type="entry name" value="DNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10459:SF60">
        <property type="entry name" value="POLY [ADP-RIBOSE] POLYMERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00644">
        <property type="entry name" value="PARP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56399">
        <property type="entry name" value="ADP-ribosylation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51059">
        <property type="entry name" value="PARP_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3 5" id="KW-0520">NAD</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PARP catalytic" evidence="7">
        <location>
            <begin position="160"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="395"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00033987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG5084465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="437" mass="51332" checksum="4CBEEA629B0F11BE" modified="2022-05-25" version="1">MAELSLKNCLDDSIKFYNKSSYENETFVYNSRKRRYSMTFWKYDPDCENRIRYYRQQILAYYFGYGGNNHYDEDEYVYVQYGGVLGTSNHFTVSERMPLEYCLERFDNSVVAKGYENFKSLVSFEGKETDVEMPYATQLLIQCIFQIKIGEIYNNGWYKHSFNNYYKMLRTDIEVMWKNSSTFDLIKQYIENTHTENHYFFKIKINDVYMIKRHGEENGYKGTLLPKKLIWHGTKTENVASILSRGLEVAPPSSESTGAHFGQGIYFTNSSSKAASYCGARRKQRTYEGILLLCEVALGHMAQCYTAQNMCPLPTQFNSVWGVGHFAPDQNVKTILWNDVEVPYGPIIERANTDTDLAHDEFVVYDPKQIKIRYLVHVNFEYNDYYDYDGNDDCDCHDDDDYDDDDDDDDDDDDDDDDDDDDDDDDDDDEDDDYYYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MEU4</accession>
    <name>A0A8J2MEU4_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Similar to SEMA5B: Semaphorin-5B (Homo sapiens)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HICCMSTLAB_LOCUS4626</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5087857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MEU4"/>
    <dbReference type="OrthoDB" id="9988752at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045499">
        <property type="term" value="F:chemorepellent activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030215">
        <property type="term" value="F:semaphorin receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007411">
        <property type="term" value="P:axon guidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030335">
        <property type="term" value="P:positive regulation of cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071526">
        <property type="term" value="P:semaphorin-plexin signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.100.10:FF:000001">
        <property type="entry name" value="semaphorin-5A isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.100.10:FF:000007">
        <property type="entry name" value="Thrombospondin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1680.10">
        <property type="entry name" value="ligand-binding face of the semaphorins, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.100.10">
        <property type="entry name" value="Thrombospondin type-1 (TSP1) repeat"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057563">
        <property type="entry name" value="Sema5A/B-like_TSP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001627">
        <property type="entry name" value="Semap_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036352">
        <property type="entry name" value="Semap_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027231">
        <property type="entry name" value="Semaphorin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000884">
        <property type="entry name" value="TSP1_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036383">
        <property type="entry name" value="TSP1_rpt_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11036">
        <property type="entry name" value="SEMAPHORIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11036:SF79">
        <property type="entry name" value="SEMAPHORIN 5C, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01403">
        <property type="entry name" value="Sema"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23260">
        <property type="entry name" value="TSP1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00090">
        <property type="entry name" value="TSP_1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01705">
        <property type="entry name" value="TSP1REPEAT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00630">
        <property type="entry name" value="Sema"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00209">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103575">
        <property type="entry name" value="Plexin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101912">
        <property type="entry name" value="Sema domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82895">
        <property type="entry name" value="TSP-1 type 1 repeat"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51004">
        <property type="entry name" value="SEMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50092">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0221">Differentiation</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0524">Neurogenesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="986"/>
            <end position="1012"/>
        </location>
    </feature>
    <feature type="domain" description="Sema" evidence="11">
        <location>
            <begin position="1"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1043"/>
            <end position="1069"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1044"/>
            <end position="1068"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAG5087857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="1106" mass="122091" checksum="1D7811FA2DE4E0C9" modified="2022-05-25" version="1">MVKPLHLNFILIKCILAKSTDNNKINNFYDILITILMIISYCRDNLYRLTLNSLTPLEHASWPAPPEKATVCQDKGQTALDCHNYIKVLLTNGKSLFTCGTNAFSPQCTWREIENINSITSSVSGVAMCPYSPQANVTALLAKENAGLFAGAPTDFSGTDGTIYRTLASPSLRTQQYDSRWLNDPQFVGSFETEDHVYFLFREIAVEYINCGKKIYSRISRVCKKDPGSPTVQRGIWTTFSKARLNCSLPGEFPFYYDEIQGAAYHPEEGIVYATFTTPSNAIAGSAICSFNMTAINQAFNGPFKHQEHSGAAWEKKRVPNQYRQHCGRLEQPPAHQIFDNQRYQLMDEAAQGTTSSPLHTTTLERFTHIAVDVTPTKIHRGVTVLYVATTEGLIKKISVLPRTQETCIVEVWGPFPSPAMTLQFLKDSQSLYVGMETGLLRIPAAQCHRHKKEQACLNAQDPYCGWNAHLMKCDQAPTQNYLANHWRQEVTTCPVLTDPVDGGWSAWSTWSSCQHGTAEMATGHNIRSHLRPHIDTESPDTCQCQTRECNNPPPQNGGSQCTGTRIKVANCTVHGGWTAWSAWSACSQTCGFAIKTRRRTCTNPAPAYGGRVCVGHDHDEIVCIDLPPCPVPAKAPPPPPTQSIGVWSPWGSWNSCSRNCNGGIRIRKRTCDKPPSSTASSTPECSGCSFQIEDCNTHSCSETRRYSWTPWLLINGSQTSMGVTEKRYKFSCRAQTDDPASVKVALAKEEERHCKDGNCLKNSVFSPTNNNFDNTDGWSEWSPWYACSRACNGGSQHRTRSCESPPCEGVNIQTRICNMNPCKGESETGNGDDDEFVQRSGRGEWSCWTDWSECSVSCGVGFRTRTRECLVDASSAASGSVALSGCEGISVMRETCEMPSCASLFGWDKWSAWSACDGQTQFRKRQCLMEPGDGICEGSSREVRKCWNIEDGDDGVSVLGAPDWGKNDILTNALPRSVHVAGISVGAVVGGCIAGFLLGLALTAMMCFLYLRRRKPGVPGSPHYISKQNPYVAVPLKEVNAKRQPSFSGTSNGNGTLRNKTNPNVNGLGSPKLYPKALDYESATLKRNSHGQQHIRADLDQEKYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MG69</accession>
    <name>A0A8J2MG69_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS4988</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5088802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MG69"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5088802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="136" mass="14565" checksum="F7FDF8908AE68651" modified="2022-05-25" version="1">MLLISSTLRNLISIDSLFKKKANPPYGNSKLCWKISFLTSSSIAVDFVTRIAVTNNFIDSVVVVVAAAGGGSLVISNLLVELLLSELQLLLIYLPGISLLKYAILSSDAAMFAVAFSNGLPRDDVVCIALKLVNSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MJF9</accession>
    <name>A0A8J2MJF9_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">E3 ubiquitin-protein ligase</fullName>
            <ecNumber evidence="12">2.3.2.26</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">HICCMSTLAB_LOCUS7728</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.26"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 12">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 12">Belongs to the UPL family. K-HECT subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.26" evidence="12"/>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5095477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="271273at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009966">
        <property type="term" value="P:regulation of signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00078">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2160.10:FF:000013">
        <property type="entry name" value="E3 ubiquitin-protein ligase TRIP12 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2410.10:FF:000005">
        <property type="entry name" value="E3 ubiquitin-protein ligase TRIP12 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.720.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2160.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2410.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000569">
        <property type="entry name" value="HECT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035983">
        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045322">
        <property type="entry name" value="HECTD1/TRIP12-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057948">
        <property type="entry name" value="TPR_TRIP12_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018123">
        <property type="entry name" value="WWE-dom_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004170">
        <property type="entry name" value="WWE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037197">
        <property type="entry name" value="WWE_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45670">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE TRIP12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45670:SF13">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE TRIP12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00632">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25579">
        <property type="entry name" value="TPR_TRIP12_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02825">
        <property type="entry name" value="WWE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00119">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00678">
        <property type="entry name" value="WWE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56204">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117839">
        <property type="entry name" value="WWE domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50237">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50918">
        <property type="entry name" value="WWE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 11 12" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="WWE" evidence="15">
        <location>
            <begin position="779"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="domain" description="HECT" evidence="14">
        <location>
            <begin position="1686"/>
            <end position="2043"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="194"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="243"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="374"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="987"/>
            <end position="1011"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1036"/>
            <end position="1152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1458"/>
            <end position="1491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="29"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="81"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="115"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="198"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="256"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="281"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="296"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="335"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="374"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="400"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="998"/>
            <end position="1011"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1046"/>
            <end position="1059"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="1068"/>
            <end position="1078"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="1084"/>
            <end position="1093"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1094"/>
            <end position="1107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1133"/>
            <end position="1149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="1465"/>
            <end position="1477"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="11">
        <location>
            <position position="2010"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU369009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CAG5095477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="2043" mass="223550" checksum="E4B08495C87D3AFC" modified="2022-05-25" version="1">MADQQDQSSLGGSVEKASASADASKLRGKNSSSAGSRKRQGTTTVVATLGEKRRKQQQQQQQQHQTDSQPSQACAIPVHRRSIDLSKGESKAKGDRKNHGGGVGSVTDTDKQKAHSSNSNSNSGRKAAVKSTVFELNSAPIDCVASRTRSRVPQVPQIIQTSSNNFQASLTSIYNNIYNNKKSSTALPNLAASSSNSFISHPSTSRGRGSKLQTVGGNYANGGTGNQVLGVKSSIRVGNAASNSVESGGGALAHDGAGTSGVTTSTGSNPPVSASASANLAHHHPTHKHLLRSRVKLSSEQSKEAQVSASTTGVNKSLSKHHKKDSTTGGSCSSSRHRSQSRARKSAGESSTSTAAIAAAAASALVMSTSDSLTNSTAIPTSASASGGQLNPSVPEEESSAASATPAAPSGGPSGMSGTTGDSESDDGEVGRLQALLEARGLPPHVFGALGPRMQHLLNRSMGASSAAKAQQLLPGLQAVDDEGEQLQAVIGMGEILVMGNEDTLTGFPVKQVVAALINLLGIEHNFVIMTHACRALTYMMEALPRSSTVVVDAVPVFLQKLESIECMDVAEQCLTALAMLSRRHSKTILHAGGVSACLKFVDFFNITAQRAALTITANCCQNLHPDDFHLVSDSLTLLTTRLTNQDKKSVECVCQAFSRLVDSFQHDPVMLHKIVTPELLQNLQQLLMITPPVNSIGNFITVLRMLSVISNRCPDLAQLLLQQNIALTLSYLLTGSLEVKTEDVELVTRSPQEWFEITCLIEELMPPLPTDGIFSVNNLLERTTSHQETVHWEWRDERHCCHPFSTIDSRIIEMAFQNGEDEICLSTLGRTYTIDLTTMKQINEDIGMARSIYRRVMTDPAENKSPTCSSSMDVVPPVIETNEWLVSFIRTLFSVLYEVYSSSAGPAVKCKCLRALLRMVYYASTDLLKDVLKNQVVSSHIAGMLASQDLRIVIGALQMGSILMKRLPQVFGVHFHREGVLHQIRHPQPGPSNTPISSTMTLSSSSAMSPVASPTTNGNILFGSIATSQLKPVVASPMETRSKSDLNTNAEEANTPQSAHLFGDVLKRKRQVKKGRFSRLGNTTTPQQTQQPDSLFTGFTQKNNRFLGNLNPARWGRKSSGSSGSGEKRDSTSSASLTKPPSNPNLTGGNRDKAKAWVREQASNFLARYQDDAPCTHPALTVLSRLTAAIQRLQSNELDEMLSALTELRDIVLESDISPFEMNYSGLIKALLNYLTTTDAPGNRYDRLRMFWKLFAESTMQQDGINIIEVNPGAFGALVHKLNSCVAQLEQFPVKVHDLPAGSGAGRGGTSALKFFNTHQLKCNLQRHPDCNNLKQWKGGTVKIDPLALVQAIERYLMVRGYGRIRDAESMVSDDENSEDDIDDTLAAVVISQGSKHKLQFLIGDEILPFNMTVYQAVRQFSCPGMDHSEAETDSEPPLGHDAVWVQTHTIYYRPVPEEEVSASPKPGSSSQGTSSRKGKGKSTKISSKRKEDSFWLEGVIPPPKCPLAPYLSPVLPSVTISDASLDGLCLLRLLHALNRHWGVLFPHLKSPALLSSQDFINTKIAAKANRQLQDPLVIMTGNLPSWLQQIATVCPFLFPFETRQLLLYATSFDRDRALQRLLDSAPELSGSDSQERVTPRLERRKRTISRTDILKQAEQVIQDLASSKALLEVQYINEVGTGLGPTLEFYALVSRELQRADLDLWHGSLNPDATGYVNGTKGLFTKPVPWNTKIPHLAKLKAKFKFLGKFMAKAIYDSRMIDMPFSLTFYRWLLGEEHTLTLADLAYVCPDVHRTLNKLQEVVRRKEAIERDQTLRPHEKAQLIESLDLDNCTIANLSLVYELPGYENIELRKGGSEISVTIHNLDQYIKLVVHWFLSEGVSRQMEAFREGFESVFPTSQLRLFFPEELEAVFCGHGQSGGQWDVKTLMECCRTDHGYTPESRAIRFLFEVMSEYNSEEQRQFIQFVTGSPRLPVGGFKSLTPPLTIVRKTFDASMKTDDFLPSVMTCVNYLKLPDYTTLEIMREKLRIAAQEGQHSFHLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MKH4</accession>
    <name>A0A8J2MKH4_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Clustered mitochondria protein homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HICCMSTLAB_LOCUS5368</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="2">mRNA-binding protein involved in proper cytoplasmic distribution of mitochondria.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CLU family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5089766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1414216at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048312">
        <property type="term" value="P:intracellular distribution of mitochondria"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd15466">
        <property type="entry name" value="CLU-central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000099">
        <property type="entry name" value="Clustered mitochondria protein homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2280.10:FF:000002">
        <property type="entry name" value="Clustered mitochondria protein homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2280.10">
        <property type="entry name" value="Hypothetical protein (hspc210)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03013">
        <property type="entry name" value="CLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033646">
        <property type="entry name" value="CLU-central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025697">
        <property type="entry name" value="CLU_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028275">
        <property type="entry name" value="CLU_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027523">
        <property type="entry name" value="CLU_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007967">
        <property type="entry name" value="GSKIP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023231">
        <property type="entry name" value="GSKIP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12601:SF6">
        <property type="entry name" value="CLUSTERED MITOCHONDRIA PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12601">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT EIF-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13236">
        <property type="entry name" value="CLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15044">
        <property type="entry name" value="CLU_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12807">
        <property type="entry name" value="eIF3_p135"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05303">
        <property type="entry name" value="GSKIP_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103107">
        <property type="entry name" value="Hypothetical protein c14orf129, hspc210"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51823">
        <property type="entry name" value="CLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Clu" evidence="4">
        <location>
            <begin position="370"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="672"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="920"/>
            <end position="939"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1320"/>
            <end position="1341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="35"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="46"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="675"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="920"/>
            <end position="930"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1320"/>
            <end position="1334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAG5089766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="1372" mass="154687" checksum="EFCBAF771C692E99" modified="2022-05-25" version="1">MALGSQVEANGKDGAVQIPMVNGTDKRVDDEQQDNEANGSNSSDNILEKGEVEATKEGEKEKDKEKDADDKEKDGEQEVVFIQDMGFTVKIVSPGGEPFDIQVSSMELVQEIHQLLMDREDTCHRTCFSLQLDGNTLDNFAELKNIEGLKEGSIIKVVEEPYTMREARIHVRHVRDLLKSVDPADAYNGVECSSLSFLNVVTNGDIMEKKKTRTDAIDCTPPDYIIPGSKERPLLPLQPQAKEQKCPPCLKVLTTSGWNPPPGYRKLHGDLMYLQVITLEDKQYYVTACARGFFVNQSSKETFNPKPATPSHLCHSLIELLNQLSPAFKRGFAAMQRRRTQRHPFERVATPYQLYAWCAPQTEHTIDAIRAEDTFSAKLGYEEHIPGQTRDWNEELQTTRELPRKNLPERLLRERAIFKVHSDFVAAATRGAVAVIDGNVMAINPGEEAKMQMFIWNNIFFSLGFDVRDHYKELGGDAAAFVAPRNDLQGVRVYAAVDLPGLYTLGTVVIDYRGYRVTAQSIIPGILEREQEQSVVYGSIDFGKTVLTHPKYLELLNKAGQQLKILPHKVINDAGEEIELCSSVECKGIIGNDSRHYVLDLLRTFPPDVNFLKLDGVELSKEARALGFPIEHKHRLACLRQELIDSFVEARYVQFIKHAAVHLQQLTSSRLSQQMEKESIGEKEKEKEKEKEKDEAKAKKEESVSAVVIDSNKETSEQSTIEADEAKKIVESITDSITGGEKQELEESTKEIVRRAAAAVGSLREAEFDVKFNPDVYSPGVRHPDPNGEAIKKQRQLVRDAADFLLTVQLPTFIRECLDHTAAATDGSTLVEALHGRGINVRYLGKLAVMLAIVPQLKYLHRISVSELILRSAKHIFTSYMQGTELMSLSAAISHFLNCLLSSAQLPHPQLNLEELQSKTAKRRNKRKGRNNGPHQSEVEWASLTPKSLWQQIKADLKSYYDWETLAPESLDSTIEHFNLQKISLLRGFCIKTGIQILLREYNFENKNRATFFEEDILNIFPVVKHINPRASDAYNFYTTGQNKIQQGYLKDGYELISEALNLLNNVYGAMHPEIAQCLRMLARLNYIMGDHGEALATQQKAVLMSERVSGIDHPYTITEYIHLALYSFANGQVSVSLRLLYRARYLALLVCGEDHPEVALIDSNISLILHAVGEYELSLRFLEHALALNLRYHGPRSLKVAVSYHLVARTQSCMGDFRAALNNEKETYAIYKQQLGEEHEKTRESSDCLRHLTQQAVVLQKKMNELYTGKSSLSLPPIQIQPPSMGSVLDLLNVINGILFVQISQQDIENLKAEIEKRQKEQIPENDIKRQDSKSSTPMINETDKILAITQDTCTNTENNKETRKSIATDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MM11</accession>
    <name>A0A8J2MM11_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Dredd_IMDPathway_Cc</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HICCMSTLAB_LOCUS3945</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the peptidase C14A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5083841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MM11"/>
    <dbReference type="OrthoDB" id="6044770at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029030">
        <property type="entry name" value="Caspase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056260">
        <property type="entry name" value="Dredd_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056259">
        <property type="entry name" value="Dredd_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002398">
        <property type="entry name" value="Pept_C14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011600">
        <property type="entry name" value="Pept_C14_caspase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002138">
        <property type="entry name" value="Pept_C14_p10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001309">
        <property type="entry name" value="Pept_C14_p20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015917">
        <property type="entry name" value="Pept_C14A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47901">
        <property type="entry name" value="CASPASE RECRUITMENT DOMAIN-CONTAINING PROTEIN 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47901:SF8">
        <property type="entry name" value="CASPASE-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23724">
        <property type="entry name" value="Dredd_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23725">
        <property type="entry name" value="Dredd_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00656">
        <property type="entry name" value="Peptidase_C14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00376">
        <property type="entry name" value="IL1BCENZYME"/>
    </dbReference>
    <dbReference type="SMART" id="SM00115">
        <property type="entry name" value="CASc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52129">
        <property type="entry name" value="Caspase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50207">
        <property type="entry name" value="CASPASE_P10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50208">
        <property type="entry name" value="CASPASE_P20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Caspase family p20" evidence="7">
        <location>
            <begin position="263"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="domain" description="Caspase family p10" evidence="6">
        <location>
            <begin position="421"/>
            <end position="513"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG5083841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="518" mass="59651" checksum="7FD586AF1FBBFF6E" modified="2022-05-25" version="1">MSQLKTDALPSAIKANYAEILDKDVVNAIEDDLTINEKISIIFLCAAEKIDTDFWRNFMQKLMSYNEKVIFDKKEAIFIICDLIENVGNWKDKFIEALCIINNKRILTQLGLIVDDLYREYCPLQARIVGKINVGNKILFKFFESLSEKESENVLKKIYSDICLDRRLSDINLMEIHALYWLSIGFIKITPTDGDLGNLLKYLKPLGYFDTPFYSDIEWYNQKYTGNKSHVYNTNSNLIKKFKSLLNLTKKAEEIDSDKILIKKGLCLIINEKNFQNDIYEVRHGSQADVDNLKKTFQALGFIVKDYENRRAIEIAKIIHQHANAENKQYDCFAVCLLSHGYPDGILSIDGEEISFEDIEKCICQKEVKNTLKLVIVQACQGQTMGLNSPRNKLAVDGVAVNSAKTKPSTSLFTDGYPSKPAKSIDYRKEFLLFKSTMKGYVAIRHKEEGSWFINDVCSVLNEFKTQLSIDEWSRQVKKKISLRHGDVEGHKAAGQLAETERDRRTKEYFFFNQFNSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MM29</accession>
    <name>A0A8J2MM29_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Eukaryotic translation initiation factor 2A</fullName>
            <shortName evidence="9">eIF-2A</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HICCMSTLAB_LOCUS8575</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="1 9">Functions in the early steps of protein synthesis of a small number of specific mRNAs. Acts by directing the binding of methionyl-tRNAi to 40S ribosomal subunits. In contrast to the eIF-2 complex, it binds methionyl-tRNAi to 40S subunits in a codon-dependent manner, whereas the eIF-2 complex binds methionyl-tRNAi to 40S subunits in a GTP-dependent manner.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the WD repeat EIF2A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5097167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MM29"/>
    <dbReference type="OrthoDB" id="2194683at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011387">
        <property type="entry name" value="TIF2A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013979">
        <property type="entry name" value="TIF_beta_prop-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011659">
        <property type="entry name" value="WD40"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13227">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13227:SF0">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08662">
        <property type="entry name" value="eIF2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07676">
        <property type="entry name" value="PD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017222">
        <property type="entry name" value="eIF2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 9 13" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="8 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="7 9" id="KW-0810">Translation regulation</keyword>
    <keyword evidence="5" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Translation initiation factor beta propellor-like" evidence="12">
        <location>
            <begin position="229"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="450"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="560"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="496"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="528"/>
            <end position="540"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR017222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF08662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAG5097167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="600" mass="67227" checksum="E357D25C0E850FA4" modified="2022-05-25" version="1">MVSGELATRGPTGKMAVNIPCVAVRGSTGISVSYGPPRYEDVSSFVKDDGRNCKCMTFSPDGKYFAWISGATVKIVSCSTWAVIAVIEKPKVCALKFSTLGTYLMTWEPFIVSAANPQGNPQLHIWKSENGEHVQSFTQKRQIDWEPQWSDDEKICAILINTDIVIYENADFGKVVHRINVTKVGRFKVAPGNAPYYIVIYTPGKTGQPSLARLFEYPKLDSAQSLATKSFFQSDRVDFYWNSKGTSVLIMTSMDIDKTGASYYGKQALHYLSTKGNTAIVTLGEEGPIHELSWSPKGNEFAVIYGFMPSKATLFNLKCDPVFEFGKKHRNSIYYNPHGNILLLGGFGNLQGGIELWDMNKRKLIAQADAADTTLLHWSPDGQHFMTATTAPRLRMANGFKIWHYSGTLLYERPWNKQEELWEIIWQRFPVNSFPEQEISYKAVEGIAPSAPQASKQVYRPPSARGRTINFKLHDDVDDNDPAKKNAGNAPSKAMLKVKKKREAKKAKKELEANAQKNNSNGQENDPAPNPTPKPKPTTPDPDLTNDPEKNKKIKLIKNKLKTINKLKELQATGKRLEKNQVEKINKEEELQLELAELTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MMQ7</accession>
    <name>A0A8J2MMQ7_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS7655</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5095330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MMQ7"/>
    <dbReference type="OrthoDB" id="5984981at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="221"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="316"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="19"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="137"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="238"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="264"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="279"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="316"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5095330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="356" mass="38230" checksum="E1182BFCCDB3B99F" modified="2022-05-25" version="1">MSEQNGPTEGPGWWPPAQSWKSSSGTTASSRTIDAGKNVSVTTINVPPVEEMHDGKSVKYLTGQNGVTVSVVSSCSSSSPLEAPIDDGDSDGEVSKIDFRGVNLRTKKKRDESECPSVESHQQPERPMSWEGELSDQEMSSNTLTNPEETSMEGVQVCGASPGPQEQKFPIKPEPDFRSSPGLIGHVDAAMPLHGQHHHHQQQHPQLEQAQQSDLPLLVGKLLGGYSSTPNHSPVLNPRHHLTKHSHTRSQVPSPDSAIHSAYSVFSSPTQSPHAARHSALGAGSPVPSSSLSLSRHSFNNSTSSLSLSLSHSLSRNNSDASSSCYSTSRKSAAPSLKRAPLKLLQHLRTGFRNPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MNN8</accession>
    <name>A0A8J2MNN8_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Similar to Hnrnpul1: Heterogeneous nuclear ribonucleoprotein U-like protein 1 (Mus musculus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HICCMSTLAB_LOCUS9954</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5100881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MNN8"/>
    <dbReference type="OrthoDB" id="445357at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000380">
        <property type="term" value="P:alternative mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12884">
        <property type="entry name" value="SPRY_hnRNP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000355">
        <property type="entry name" value="Heterogeneous nuclear ribonucleoprotein U-like 1, isoform CRA_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.720.30">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003034">
        <property type="entry name" value="SAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036361">
        <property type="entry name" value="SAP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035778">
        <property type="entry name" value="SPRY_hnRNP_U"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12381:SF56">
        <property type="entry name" value="B30.2_SPRY DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12381">
        <property type="entry name" value="HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN U FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13671">
        <property type="entry name" value="AAA_33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02037">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00513">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF68906">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50800">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0488">Methylation</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0687">Ribonucleoprotein</keyword>
    <feature type="domain" description="SAP" evidence="7">
        <location>
            <begin position="3"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="domain" description="B30.2/SPRY" evidence="6">
        <location>
            <begin position="372"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="35"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="153"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="789"/>
            <end position="1009"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1023"/>
            <end position="1069"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="39"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="63"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="82"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="98"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="168"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="249"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="260"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="285"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="338"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="382"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="805"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="852"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="874"/>
            <end position="884"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="899"/>
            <end position="920"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="934"/>
            <end position="951"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="959"/>
            <end position="972"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="980"/>
            <end position="1009"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1030"/>
            <end position="1068"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG5100881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="1093" mass="120657" checksum="A34E15491B08D124" modified="2022-05-25" version="1">MDPAKLKVVELRSELQKRNLDSKGVKAVLVERLRKALEDESDAVEQETSDSCRKNSSEPSVDDIEKREKSPEVTKVPPSPVKTPAKSSKRSSMGGSSPTKVTSTRSSPKASTASPDKVTQESPVKSPTVEKASPIIETPVSVPVPVATPAAVVTNDHIDDENDKSLTKIDNTPVELTTESSEAELCTPQVAEEAPEILPSIQDEPEAVSKTATGTAEASKMEVSPDECEELPDKLVAVENKIEQEDEHVEEKDCPKESEEISESNEDVGDNDATNLNENNKSELDDTMEVNDEDSYEKSSIMNETAGDDVSSADNQATEVMKVEPEQEEETISQSKQGEVEGEKANEDSGEKKKEHDEHEPKDNQDRRDRKDRKRKRSNSSQDERHKSPSRMDDEPEIDYSRVLLSWYDSDLNLIIDKSKFLSATPMHNDGFGYVWAGARASFGFTNGKVYYEVKITHQCNVTLDNEENPHILRAGWSVPLTSMQLGEEKLSYGYGETGKKCTDSNFTEYGPAFGLNDIVGCYLDMSNDDDVVISYSLNNESLGEAFRFPKSELDGKALFPHILTKNYAFVCNFGDEEPWSTNVLEGYTPVGKVDANERIPGIRRPDNRQDCEILMMVGLPSAGKTVWANKFSNQNLEKKYNILGVSNILDRMKVMGLPRRDNHKGNWDQLVGKCTRCLNKLIEVAATRRRNYILDQTNVYPSAQRRKMRQFSGFQRKAIIIVPTDEEFKSRAAQREQVDGKDLPDSEFMEMKANFAAPTVGESFDTIEWIELDEEEAKKLIAKYNKEGKDAGFGQQQSSSSKRPRLEKSDTHRDNRDMRSSRDSRDTRDHRDRRNIYSDRSRNSSWRGSMGASGGGGGGGWRDRGPRSGPPMRHSSSYGSSSRGWGGRGGPSSSQSHRGSDRRGSSSTDRRSGIVDRSRSGSLRQSGGWGPMNSNSYHNSSHSSSAWSGSGHSGGGWSSQSQAQASNSWGSSGSGSGSWSGQQQSSWSNWKGYGGQSNQSSYQSGYGNGNWGSWNQPQYYNHQYWGPHQSQSQSLSSSGQSGSTTGGSSTSASAASTGSTYNSNSSSYPQGWQYSASYYSTDSSTPNAQQQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MNU2</accession>
    <name>A0A8J2MNU2_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Similar to Det1: DET1 homolog (Mus musculus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS9135</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5099590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MNU2"/>
    <dbReference type="OrthoDB" id="18339at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031461">
        <property type="term" value="C:cullin-RING ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990756">
        <property type="term" value="F:ubiquitin-like ligase-substrate adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032436">
        <property type="term" value="P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019138">
        <property type="entry name" value="De-etiolated_protein_1_Det1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13374:SF3">
        <property type="entry name" value="DET1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13374">
        <property type="entry name" value="DET1 HOMOLOG DE-ETIOLATED-1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09737">
        <property type="entry name" value="Det1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5099590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="462" mass="53832" checksum="6796C36A244DBD29" modified="2022-05-25" version="1">MAEEKRKIEFVDGPCRIKPRKFPAQNIVLRLRRRETIGCQYPGTQVLVARQFYQNVFPNFTVVNVEKPPCFLRKFSPDGRFLVAFSADQTSIEIYTNNEALTPNPRSPLEDYTLHLIDLKSGKFCDYRRFLVDKIYLSHNQGLYLYKDILAVLSVQHQTIHIFQILDGMFIEVRTIGRFCLEDESYLLASAYPNINTRPYKDTMINTLKHKLLIHLYKRAAYISSNSKDPYELRRFYQYFDQFEALRMWKMQLLDTNHILVRYASEEVATLQTTDPNAHPALLVVYNMVSAKVIAAYDNASLHMQTQFENFTDFFRNSDTSYMCSPSNNIYARLTQQRYKQTIVSARYGGLTEATKRLLSQLPICAQSYSSSPYLDLSLFCYDDKWVSMMERPKACAEHPIRFYARDSGLLKFRLHAGMLGRTTPVVARRLVAFTFHPTDPFAISVQRTNAEYIVSFHVRHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MQ56</accession>
    <name>A0A8J2MQ56_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Small G protein signaling modulator 3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">RUN and TBC1 domain-containing protein 3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HICCMSTLAB_LOCUS5097</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the small G protein signaling modulator family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5089087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MQ56"/>
    <dbReference type="OrthoDB" id="44736at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17688">
        <property type="entry name" value="RUN_SGSM3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11813">
        <property type="entry name" value="SH3_SGSM3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.270:FF:000013">
        <property type="entry name" value="Small G protein signaling modulator 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.900:FF:000016">
        <property type="entry name" value="Small G protein signaling modulator 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000115">
        <property type="entry name" value="Small G protein signaling modulator 3 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.900">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.750">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050302">
        <property type="entry name" value="Rab_GAP_TBC_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004012">
        <property type="entry name" value="Run_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037213">
        <property type="entry name" value="Run_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035833">
        <property type="entry name" value="SGSM3_SH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219">
        <property type="entry name" value="RAB GTPASE-ACTIVATING PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219:SF13">
        <property type="entry name" value="RUN AND TBC1 DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02759">
        <property type="entry name" value="RUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00593">
        <property type="entry name" value="RUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140741">
        <property type="entry name" value="RUN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50826">
        <property type="entry name" value="RUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="8">
        <location>
            <begin position="134"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="7">
        <location>
            <begin position="434"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="domain" description="RUN" evidence="9">
        <location>
            <begin position="509"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="7"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="701"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00030864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00073333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAG5089087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="701" mass="80860" checksum="FE3823F55C163348" modified="2022-05-25" version="1" fragment="single">KKLETLGSEDEYDGDFNESSEDLISPVPGGPFSALTPSMWPQDILAKLNQPEDPNSQPDYRFDEFGFRVEEEDGPEQSSKKLLGVPFVEDPQHRQQWLTLMEFSRSQEIPETLWHRTDQRLPRTDKLREMVRRGIPHSLRPRIWMRMSGALHKKISSDMSYKDIVKASSSDALMTSKQIEKDLLRTMPANSCFSNLHSTGIPRLRRVMRGLAWLYPDIGYCQGTGTMAASLLLLLEEEDAFWMMATIVEDLLPASYYSSTLLGVQADQRVLRTLIANYLPDIDHVLSQHDIELSLISLHWFLTLFASVVHMKILLRIWDLRRHLAYLMADQGGLVGNPDAVPNLPKQHLNKRQMKRNKSVLQTFLFGSDDSEEDAKSKNIRQTEILVDLRETILQLARHFINVDPKLTNVSLIADYTMESHSKDHDNYVNVSRTRNRRAKALLDFERHDDDELGFRKNDIITIISQKDEHCWVGELNGLRGWFPAKFVELLDERSKQYTCAGDDAVSEAVTDLVRGSLCPAVKAFLEHGMRRPSFLGGSCHPWLFIEEASTREVEKDFNSVYSRLVLCKTYRLDEDGKVLTPEELLYRCVQAVNLTHDNAHAQMDVKLRSLICLGLNEQVLHLWLEVLCSCVEIVQKWYQPWSYINSPGWVQVKCELRILSQFAFNLNPDWELPRKKEQSQPLKDGVRDMLVKHHLFSWDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MQU0</accession>
    <name>A0A8J2MQU0_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Similar to LAC: Lachesin (Schistocerca americana)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HICCMSTLAB_LOCUS11616</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5103651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MQU0"/>
    <dbReference type="OrthoDB" id="10010359at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098609">
        <property type="term" value="P:cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000005">
        <property type="entry name" value="Neuronal cell adhesion molecule"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013106">
        <property type="entry name" value="Ig_V-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051170">
        <property type="entry name" value="Neural/epithelial_adhesion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12231">
        <property type="entry name" value="CTX-RELATED TYPE I TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12231:SF220">
        <property type="entry name" value="LACHESIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07686">
        <property type="entry name" value="V-set"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00406">
        <property type="entry name" value="IGv"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="5 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 10" id="KW-0732">Signal</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035233227" evidence="10">
        <location>
            <begin position="18"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="663"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="11">
        <location>
            <begin position="21"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="11">
        <location>
            <begin position="130"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="11">
        <location>
            <begin position="221"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="11">
        <location>
            <begin position="356"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="11">
        <location>
            <begin position="465"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="11">
        <location>
            <begin position="556"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAG5103651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="693" mass="77275" checksum="FF1D3F7B16E6E98E" modified="2022-05-25" version="1" fragment="single">MKFIILIAAAFIQSITCQRAPTISYISQEQIKDIGGTVELQCSVQYGQEYPVLWVKMDKQTGDQTPLSSKTSLIIRDSRFALRFDTATATYTLQIKDIQETDAARYECQVLISVNNRIRASVELQVRRAPFISDNSTRAVVASEGEPITLECYASGYPAPRISWRRENNAILPTGGSIYRGNVLKIPAVRKEDRGTYYCVADNSVGRGTRRNINVEVEFAPVITVSRPREGQALQFDADLKCHVEGYPSPAITWLQNGVELSSNQHYIISQFATADEYTDATLRIVTVEKRQYGEYVCRANNKLGTREAKLELYETIIPVCPPACGQAKYGTGAIPVSSGPLIALVMLTVALYKAPMISHISEKQIKDIGGTVELQCSVQYGQEYPVLWMKTDQQTGDQTPLSAKTSLIIRDSRFALRFDTATATYTLQIKDIQDIDAAFYECQVLLSSTNRIRRKVELQVRRAPFISDNSTRNAQVTEGQPVTLECYASGYPAPKIFWRRENNAILPTGGSIYRGNVLKIPAVRKEDRGTYYCVADNSVGRGTRRNINVEVEFAPVITVSRPREGQALQFDAELKCRVEGYPKPIVTWLKNGAELSNNQHYIISPFTTDDEYTDATLRIVIVEEKQYGEYVCRANNKLGSSEAKIELYETIIPVCPPACGQVMYGTGVITVSYAPLIALVLIIAALNFNAKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MQU4</accession>
    <name>A0A8J2MQU4_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Olfactory receptor 36</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HICCMSTLAB_LOCUS10618</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5101716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MQU4"/>
    <dbReference type="OrthoDB" id="6604226at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005549">
        <property type="term" value="F:odorant binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004984">
        <property type="term" value="F:olfactory receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004117">
        <property type="entry name" value="7tm6_olfct_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21137">
        <property type="entry name" value="ODORANT RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21137:SF35">
        <property type="entry name" value="ODORANT RECEPTOR 19A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02949">
        <property type="entry name" value="7tm_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0552">Olfaction</keyword>
    <keyword evidence="8 11" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="9" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="45"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="136"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="176"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="305"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="333"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAG5101716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="432" mass="49941" checksum="A3100F77C0FD22BF" modified="2022-05-25" version="1" fragment="single">MKSTPIETHRTFLDKSIKVLRYCGVLTFDSAAPKYQKFYNSTIRIFNYIVIVFYFFTLVTDAVVNYKDLMTVADDGCFIAGWIVTYFKIYKFYTHRHKIGKLIDDIHDPVDALRQSCDLGVLTTMKTYMFFDALDFYLFSNCAVTLGAALVILVPREKGKLPVRAIFPFDITKSPMYELALFIQLYTLIFGLISVAMEEFISLGFLRWTTLQLKVLSANYRNCESYSSKLSDLYLSQDTYKAIQKFKILDALDEDTEITTFVEFDRRKFGKIIDSFKWRFKSCVKHHQRITHIIDDLNDVFDSCLIVQFAVSLFLICLNGFLIVMCADDRKKLISAFTYLAVGFLQLLYWCGFGNELSFQANSLTTSQWMSGWENWFEIGMKDLVTTAMIRTMQPLEMRAGGIFVLSMDTFINILKSSYSVFVLMTTVTSDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MRP1</accession>
    <name>A0A8J2MRP1_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HICCMSTLAB_LOCUS5808</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the DEAD box helicase family. DEAH subfamily. PRP16 sub-subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5090942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MRP1"/>
    <dbReference type="OrthoDB" id="10253254at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034458">
        <property type="term" value="F:3'-5' RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003006">
        <property type="term" value="P:developmental process involved in reproduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18791">
        <property type="entry name" value="SF2_C_RHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1080:FF:000001">
        <property type="entry name" value="Pre-mRNA-splicing factor ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000007">
        <property type="entry name" value="Pre-mRNA-splicing factor ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000615">
        <property type="entry name" value="pre-mRNA-splicing factor ATP-dependent RNA helicase DEAH7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011709">
        <property type="entry name" value="DEAD-box_helicase_OB_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048333">
        <property type="entry name" value="HA2_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF91">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR ATP-DEPENDENT RNA HELICASE PRP16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21010">
        <property type="entry name" value="HA2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07717">
        <property type="entry name" value="OB_NTP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04408">
        <property type="entry name" value="WHD_HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 13" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="11">
        <location>
            <begin position="423"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="12">
        <location>
            <begin position="600"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="24"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="240"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="364"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1065"/>
            <end position="1105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="85"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="172"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="367"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAG5090942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="1105" mass="126692" checksum="2C8A9E88679D578C" modified="2022-05-25" version="1">MDLDLYELKGTDECNEVGGLIIMKKKPSEHAFKKPTLPPVIPSSKKFDKKELDQDTASFSSSKKEKRKYRAPADETPTHTGGVDRAARERLEQRLKKQRHDGHSRDREYKRHRERSSERDRRERDRDRHYDDRRSERRDSYRSNDDEVIKKSSWDHPTPKHYGSQREHSVRSEFTPSYKYNSWNKDRKPSGATPKPEIEDSEYWEEEQKRLDREWYNTDDYESRQFSNIPEEYVKKKEMELQTKPQKRMSAQQKQTNKDDNKWAVNRMVTAGVATLLTQDDLDEEAEARVHVLVHHVVPPFLDGRIVFTKQPEPVIPVKDPNSDMALAARKGSALVHHYREQNDRRKNQKRHVELGGTRLGNIMGVKDQRNEDREKPGQEVDYKSGQKYAKHMDSNSSSTKRRQEILNQRRSLPVFAVKGELLRVIRENNVVIIVGETGSGKTTQLTQYLYEEGYAKNGLIGCTQPRRVAAMSVAKRVSDEMDSNLGDKVGYAIRFEDCTSKDTVIKYMTDGILLRESLREKDLDKYSVIIMDEAHERSLSTDVLFGLLRDIVKERMDLKLIVTSATMDSTKFAEFFGSAPTYTIPGRTFPVEHMYAKNSVEDYVDAAVKQVLQIHLQPKSGDILVFMPGQEDIEVTCQVLKERLEEIESAPELLILPIYSQLPSDLQAKIFQKSQEVRKCVVATNIAETSLTVDGIVFVVDSGYCKLKVYNPKIGMDALQVYPVSRANADQRAGRAGRTGPGICYRLYTRKQYLDELLLTGVPEIQRTNLANTVLLLKSLGVENLLAFKFMDPPPEDNILNSLYQLWILKALNNTGELTALGRQMAEFPLDPPQCQMLIVASQLGCTSEILIIVSMLSVPSIFYRPKGREEDSDSAREKFQVPESDHLTFLNVYNQWKSNGYSSTWCTEHFIHAKAMRKVREVRLQLEEILKQQKLELVSCGTDWDVVRKCICSAYFQQAARLKGIGEYINLRTGMPCHLHPTSALFGMGFTPDYVVYHELVMTAREYMQCVTAVDGHWLAELGPMFFSVKETAGGGRAKMKQTLQRMNAMEEQMKQAELEMKAKAQEQLQREQASIRHQEISTPGRFEPGTPMSCRKPGSFGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MRX9</accession>
    <name>A0A8J2MRX9_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS6065</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5092339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MRX9"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5092339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="229" mass="26173" checksum="86D664AF364E8601" modified="2022-05-25" version="1">MDDWLQCVCVIFYRFWISIVRLINNNCKRGFISGIYWVGITILNDYTSIDIIFPRMLRIFVTNLRNTSSVLSIFILPAIIIILLYHNRSIHIRPIRIVRKSIANLHVLRSIHDVFSITFGINVVSLISSGTIRNYRFSLVRVGHKITQVQVSSQPTTVLNKKGLKFRKTNNIKYLLGITLLTTSNVATVMDNMPATVCFRYYGPSVPVPLFIEETRTSCACENTPQTVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MT25</accession>
    <name>A0A8J2MT25_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">acylaminoacyl-peptidase</fullName>
            <ecNumber evidence="5">3.4.19.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HICCMSTLAB_LOCUS13249</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Cleavage of an N-acetyl or N-formyl amino acid from the N-terminus of a polypeptide.</text>
            <dbReference type="EC" id="3.4.19.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase S9C family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.1" evidence="5"/>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5108462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MT25"/>
    <dbReference type="OrthoDB" id="416344at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008242">
        <property type="term" value="F:omega peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045550">
        <property type="entry name" value="AARE_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001375">
        <property type="entry name" value="Peptidase_S9_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42776:SF4">
        <property type="entry name" value="ACYLAMINO-ACID-RELEASING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42776">
        <property type="entry name" value="SERINE PEPTIDASE S9 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19283">
        <property type="entry name" value="APEH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00326">
        <property type="entry name" value="Peptidase_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acylamino-acid-releasing enzyme N-terminal" evidence="9">
        <location>
            <begin position="11"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S9 prolyl oligopeptidase catalytic" evidence="8">
        <location>
            <begin position="501"/>
            <end position="698"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF19283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAG5108462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="738" mass="83735" checksum="BD8894F5FD91CC71" modified="2022-05-25" version="1">MSSTQVDKILKLYRSLAQYPSLSSAKLTWVGDNQLIVRSSWSERNLERSSNQKYSVDYFISADNFKVVTSTFPVDITSELLSKTSFDGNYKAVLRSVPGKDKDPAVKQFIEIWNKDCLLKNYDLSALDVHGDVYSDGEFGSFEWSSDSNKLIYIAEKKLKKSEPFYKQKSLDSKKNDDKSDNDETTKGNEYIYKGDWGEQLVGKHIPAICMLDTNLNTIVNLPGIPDDLSPGQIIWTPANDAIVGIALKHEPRRLGLIFCTNRESWIFLLKDGKMEKLSNDNCCVRSPRFSPDGKHLVWIERDLSGPHHNAQRLMHILWEEPLKKPSILIDVVPKSITIESNKQFYGVYNRVLPRRCWSSDSRYLFFSNPQRSNVQSYILDMETKKLTEIKNDTSSLSILDVKNNIILFSRTSLVDYPKLFIGRFNSNNLSRVSLNRVSAEIKAVDFTNIKYEFNEYQYNNNEEVRDFNYIYFGPKTGADKSCPLIVVPHGGPHSAFANIFSLEASLYTLLGIGILQVNYRGSTGMGSDNVEYLQGRVGTTDVIDCVTATQEALKKYPWLDPERVGLSGGSHGGFLVAHLSGQYKNMYKSVVARNPFAGLYFSRNALFKDERMALGHDVCAAAINQPYRQSFSGEPKCYAEEMTIKMFKCSPIVYADNVKAPTLVCIGKNDLRVPPSQGKHWYHRLKANGVTTKYVLMYHEYTMLVYDDNHPLSSGPVEIDEIINAALWLLEHLKVNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MTF4</accession>
    <name>A0A8J2MTF4_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similar to SAP30BP: SAP30-binding protein (Homo sapiens)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS9391</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5100114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MTF4"/>
    <dbReference type="OrthoDB" id="1714508at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012479">
        <property type="entry name" value="SAP30BP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13464:SF0">
        <property type="entry name" value="SAP30-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13464">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATOR PROTEIN HCNGP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07818">
        <property type="entry name" value="HCNGP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="120"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="277"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="74"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="142"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="307"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5100114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="351" mass="37937" checksum="DE7E9D350E8CF083" modified="2022-05-25" version="1">MSVQSVALASLTATYTDSEGEDGVDDELQENNSTPQGAVPYNNAQVGQPQQAHTSPKSGRSASNSPNVASGVGKKSISNLPSNKNPPSSTLVITENLTVHNKVHRLVSYFDDTIVSDDEGAANLPSEGNPPNHNGVTPSVKSGEKSPSRHPGELVSDGPEFSDAPDPDGVVIPPEPPGQYPPDLQEKITVLFRKMESKGGVDMNQAIQQRKDFRNPSIYEKLIQFCSINELGTNYPPDRFDPFKWGKDSYYEELAKVQKAEMDKLEKARKEKTKIEIVSGTAKRPNSSAPTVEEDAKKRKSKWDQVATGTANPNIKPTVLLSQPTLTTLNASSATKATVISAFGSLPKKRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MTX4</accession>
    <name>A0A8J2MTX4_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Endonuclease/exonuclease/phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS13008</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5107979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MTX4"/>
    <dbReference type="OrthoDB" id="7684827at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5107979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="374" mass="43418" checksum="18E7E99338FDF5FC" modified="2022-05-25" version="1">MPRALSESELQEELKKRRNKKLMIRINHKCRTNEKAIKTVEEKLEIKVDWNTVGRSEQGTISLKFKNMEEKKNIVTKKWKLKGTEIYIDDEMTEREREKKNKNKNSAEKEKPSKVMCWNIAGIKEYSELNKLVENYDVVSLIETWVEEKDKEKVIKNLSSELKWWCKPAERKESCTRGRASSGHLIGVKKVYEKDWEIKEWKFGFTIRNDCRSELIVTVYNNVGIKKIKNVMKKYECEYENIIVIGDMNARIGECMVPGLSEDNNKKRKSKDKVINAEGKKLLKLCDDLGLKILNGATMGDRAGEMTFIGGKNEDCCSVLDLALQLDRGDEVNIMEFRVLKRIESDHLPIHIITRRNSVGVIEKDKKSVNIKKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MU31</accession>
    <name>A0A8J2MU31_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Similar to Tmcc1: Transmembrane and coiled-coil domains protein 1 (Mus musculus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HICCMSTLAB_LOCUS14010</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TEX28 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001236">
        <property type="protein sequence ID" value="CAG5109374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MU31"/>
    <dbReference type="OrthoDB" id="1323at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019394">
        <property type="entry name" value="TEX28/TMCC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17613">
        <property type="entry name" value="CEREBRAL PROTEIN-11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17613:SF14">
        <property type="entry name" value="DEMENTIN, ISOFORM H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10267">
        <property type="entry name" value="Tmemb_cc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="214"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="252"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="84"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="56"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAG5109374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="294" mass="33180" checksum="9F786548E911585B" modified="2022-05-25" version="1" fragment="single">GSTFYVNDPPRAGTGDNGSVEEEKTHHGSATLPGGCSLGSTHSAAPVKFPSEEGSECSSVTSESGPGSRGQAHACHSNNAAFSLKSIFVELQEHRENFERMREKLETLKTLQQEVTFLSNALQEERFRCERLEEQMNDLTELHQNEVENLKQTITDMEEKVQYQSEDRLRDIHEMLENCQTKIWKMEHQQQQHQQYVTLEGLDNSNARALVVKLINVVLTVLQVILLLVATGAGIMMPFLRTSCTKPHCFMCRVRILTTTLVVLGIIFVLKQWPEVHDVGSHLMRHLKQTLAVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MU87</accession>
    <name>A0A8J2MU87_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Similar to Atf3: Activating transcription factor 3 (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HICCMSTLAB_LOCUS8001</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subunit">
        <text evidence="6">Homodimer. Heterodimer with Jra. The kay-Jra heterodimer binds more stably to the AP-1 site than either of the two proteins alone.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the bZIP family. Fos subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5096021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MU87"/>
    <dbReference type="OrthoDB" id="2596881at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14722">
        <property type="entry name" value="bZIP_ATF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.170:FF:000006">
        <property type="entry name" value="fos-related antigen 2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000837">
        <property type="entry name" value="AP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23351:SF24">
        <property type="entry name" value="ACTIVATING TRANSCRIPTION FACTOR 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23351">
        <property type="entry name" value="FOS TRANSCRIPTION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00170">
        <property type="entry name" value="bZIP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00042">
        <property type="entry name" value="LEUZIPPRFOS"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0010">Activator</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BZIP" evidence="9">
        <location>
            <begin position="132"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="47"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="85"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="164"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="47"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="58"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="94"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="109"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00044005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAG5096021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="277" mass="31174" checksum="277DE13BCA195C95" modified="2022-05-25" version="1">MYNLNVNVNPSPTATAGLLGVSAGEVTPRTPEIVNSLIAMTNPFENYSHDRCRDRTDSTSSGGDLSPPSVQHTCSQLIKEGLKLTLQTKRRAHNSGDESKKKTKKEYGSADDEEDDDSGNNSSRVGLTPEDEERRRRRRERNKIAATKCRLKKREKTVILVQESETLESQNHDLKSQIQELETQRRRLVDMLSLHGPTCLKQGNTNTNNTDTAYQQPYNSDPILLPFTDNYSTTLDQPQDCITIDFPVKIENYDSTPQNYYRQDSPYVPTSDAGCTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MUX4</accession>
    <name>A0A8J2MUX4_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS8427</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5096871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MUX4"/>
    <dbReference type="OrthoDB" id="10060618at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5096871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="106" mass="12066" checksum="CA1554D47897D0CD" modified="2022-05-25" version="1">MDRKSARGNNSRPDRNKKKRFSSNRFTVEKDCSYTSASAAKLKKFDDEEIVINKNFGYCLLEFFSVFQTLSTLIVCATCKEEIKFSQTSPRGLGFKIALQCSCKNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MW04</accession>
    <name>A0A8J2MW04_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS9380</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5100092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MW04"/>
    <dbReference type="OrthoDB" id="10251744at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.2050">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036224">
        <property type="entry name" value="GINS_bundle-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038437">
        <property type="entry name" value="GINS_Psf3_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158573">
        <property type="entry name" value="GINS helical bundle-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5100092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="97" mass="11362" checksum="9253E5CF367CB897" modified="2022-05-25" version="1">MLLTQLNNRESEKIKETLILIFKSRIRLVMDLTQNPHSNPTLASQLPMLERNLFITGRKARLVLIEWLKQGSGNIEKSELVANLMKKRKRDEFETDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MWJ7</accession>
    <name>A0A8J2MWJ7_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">adenylate cyclase</fullName>
            <ecNumber evidence="4">4.6.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">HICCMSTLAB_LOCUS10540</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP = 3',5'-cyclic AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:15389"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58165"/>
            <dbReference type="EC" id="4.6.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="17">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="17">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="17">Binds 2 magnesium ions per subunit. Is also active with manganese (in vitro).</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="18">Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.1" evidence="4"/>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5101638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="60033at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004016">
        <property type="term" value="F:adenylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007189">
        <property type="term" value="P:adenylate cyclase-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006171">
        <property type="term" value="P:cAMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    <dbReference type="CDD" id="cd07302">
        <property type="entry name" value="CHD"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="Adenylate cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Adenylate cyclase 8 (brain)"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001054">
        <property type="entry name" value="A/G_cyclase"/>
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        <property type="entry name" value="A/G_cyclase_CS"/>
    </dbReference>
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        <property type="entry name" value="AC_N"/>
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        <property type="entry name" value="Adcy"/>
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    <dbReference type="InterPro" id="IPR009398">
        <property type="entry name" value="Adcy_conserved_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45627">
        <property type="entry name" value="ADENYLATE CYCLASE TYPE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45627:SF1">
        <property type="entry name" value="ADENYLATE CYCLASE TYPE 8"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF16214">
        <property type="entry name" value="AC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06327">
        <property type="entry name" value="Adcy_cons_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Guanylate_cyc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039050">
        <property type="entry name" value="Ade_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00044">
        <property type="entry name" value="CYCc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="2"/>
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    <dbReference type="PROSITE" id="PS00452">
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    <dbReference type="PROSITE" id="PS50125">
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        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0115">cAMP biosynthesis</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="15 18" id="KW-0456">Lyase</keyword>
    <keyword evidence="10 17" id="KW-0460">Magnesium</keyword>
    <keyword evidence="17" id="KW-0464">Manganese</keyword>
    <keyword evidence="13 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 20" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="148"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="180"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="207"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="237"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="261"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="292"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="716"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="739"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="785"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="955"/>
            <end position="975"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="980"/>
            <end position="1000"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="1012"/>
            <end position="1032"/>
        </location>
    </feature>
    <feature type="domain" description="Guanylate cyclase" evidence="21">
        <location>
            <begin position="393"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="domain" description="Guanylate cyclase" evidence="21">
        <location>
            <begin position="1100"/>
            <end position="1239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="51"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="572"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="654"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="19">
        <location>
            <begin position="60"/>
            <end position="69"/>
        </location>
    </feature>
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        <location>
            <begin position="398"/>
            <end position="403"/>
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        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
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        <location>
            <position position="398"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
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        <location>
            <position position="398"/>
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        <ligand>
            <name>Mg(2+)</name>
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        <location>
            <position position="399"/>
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        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
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            <note>catalytic</note>
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    <feature type="binding site" evidence="16">
        <location>
            <begin position="440"/>
            <end position="442"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
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        <location>
            <position position="442"/>
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        <ligand>
            <name>Mg(2+)</name>
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        <location>
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        <ligand>
            <name>Mg(2+)</name>
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            <name>ATP</name>
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        <location>
            <position position="1150"/>
        </location>
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            <name>ATP</name>
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        <location>
            <begin position="1226"/>
            <end position="1228"/>
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        <ligand>
            <name>ATP</name>
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        <location>
            <begin position="1233"/>
            <end position="1237"/>
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            <name>ATP</name>
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            <position position="1273"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00001593"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
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    </evidence>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR039050-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR039050-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU000405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CAG5101638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="1322" mass="150295" checksum="2CF5F162BD20B2C9" modified="2022-05-25" version="1">MITEQTWTMMLEPDVPGIDEYVKLGISPRKQLWIKAVKKLTSERLGREGLAAWGVGPPPLEEEEDEQQQDEAKACDKEEVTLVVAPPEAAVLQDEPEKPEEPPCQQNVFKRGRMYKGIFCPSLTNAFHSPSLEKSYFQYSCRQRQKSLMMLNVVDLGLKIAIISMWLWRRNERSSSLIQTLSWVSCCMLANIVVCVVGLWRWFSPNYLYWASICTWLLINIQGFIAAGLNFSSQQRIMWYILFVVYAPYAMLPLPLRWCVLAGSGTALSHMTMIITTLFYNSNYLKDVVCVIRMLTTNTLLYFAVNLAGMYTKYLTDRGQRQAFLETHRSMETRQRTQNENNRQEKLLLSVLPDFVAKEMIRDIARETASGGTFSFTPNQFHRIYLHRYENVSILFADIKGFTALASQCSAQELVKVLNDLFARFDRLSAENHCLRIKLLGDCYYCISGLPVARSDHAHCCVEMGLHMIKAIRDIRYTTKTDLNMRIGIHSGSVLCGVLGLRKWQFDVWSYDVTLANHLESGGIPGRVHISAETLKCLNDVYEVEPGNGVDRDNYLKDRQVVTYLIKQTEPLRSKRRQSSRPKIWTEDETGGRSKKSFKIANALLSNNHSSSKDNMTNCKDEDDIGVDWTPEIPFENLNSANSMSNLEAEYLEDEEDESGVAGGEKKPGGAAGGFETASNKRMRLANINAWTLRYNDESLETKFGQLREDMFKSNMICCFVIWLFIAICQAIIVPDCIILLASLFFTTAVLIVCSILVMAEEFKTLPAVLQNASSTLTHNKLHRTIFICILISLMAFTSLIGVLGCPVTTFNPSESLPVMDKLIDKNNYDKFNDSNSNSVLKSKSIPGLDKFIFNFLKVAFDDKNEEYLTDLSRNNKIKGSNVNDNNYFNDEKIKSNHRHTVLKRHGRKFQAFKQDLNNYKYKTRRILSVNGNDNLNWTESSIFKLDKTCFRSEYIVFTWILCLMALASALKLYYLVKTVLASIIVFMYAGLILVGYQELFLMTDDDPNETAMPLSAQMLIFLIVFLVVVTYHGRQVEVTSRLDFLWKQQAERELGDMMESKHNNMQLLKNILPDHVANHFLTAEHPPEELYSQSRDKVGVMFASVPNFTEFYSEDVNKGMECIRLLNEIIADFDELLDEPPFHCIEKIKTVGATYMAASGLNPSTLDPTKDDMDHLCKLVDYAVAMRLRLEDVNVHSFNNFDLRVGISFGPLVGGVIGARKPVYDIWGNTVNEASRMDSTGVMGKIQVPRDSAKILEARGYHTQKRGMIEVKGKGTMETYFVLGKDTQQSGISSRNRSMCRSLAAVVYGVVQARRKQMTIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2E144</accession>
    <name>A0A8J2E144_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to Fbxl4: F-box/LRR-repeat protein 4 (Mus musculus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS578</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001114">
        <property type="protein sequence ID" value="CAG5073735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2E144"/>
    <dbReference type="OrthoDB" id="2153609at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031146">
        <property type="term" value="P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057207">
        <property type="entry name" value="FBXL15_LRR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006553">
        <property type="entry name" value="Leu-rich_rpt_Cys-con_subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13318:SF152">
        <property type="entry name" value="F-BOX_LRR-REPEAT PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13318">
        <property type="entry name" value="PARTNER OF PAIRED, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25372">
        <property type="entry name" value="DUF7885"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00367">
        <property type="entry name" value="LRR_CC"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="251"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5073735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="580" mass="65893" checksum="02F111EBC0B7F9C2" modified="2022-05-25" version="1">MVSCDETRIELVPIIKDNNYKNGCKEETVTFVEQYVKDVKDFSSQYGSNINIEYHKEVYPIRVSIYETYNPGSVIKISARDSYGQWLLLWSGLPQKVSPKPRIFSPSLKLCSFKTKVLRLEFNHSQLDYYTELDAVLLIGTTELILPHVGFKNRNLSALLQQLGGHSSSSSDDSYNLTPDHTKAHCDLLKLKRTLLSKLGLNCHCIPPIEEAFNSLQQFLQEDFPKLIKDINVSSQSVHDVSANSNTSDICGNFSVLPDETVLKILKNLDLKSLCRICRVNKYFNVIARDALLYTSLNLKPYWNCIDTSALSIIQPRCKYLQRLDLSWCGNYESITSQNFIDFMHSSGCSLTHLRLNCCRFVNDHVVSEISSVCKNLKELCLRNCTSVTTEGFGNLDKLHCLERLELYRTSIETAELCSILKNNKKIRHLNLAGVNDRLNMDEIVGRSKLSRQSEYVPSHVVLDYANGGVGAPGDSLRTFLACCTSLEKVFLSALRGLTDRDIEPLLLCQQLQQLDILGARSLTSDICLRFLLCCPQLRMMDLSFCDAISDTKVQEWRQLYPHVSIKRSFQVSCRDIPRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2E1F6</accession>
    <name>A0A8J2E1F6_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Similar to SLC17A5: Sialin (Homo sapiens)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HICCMSTLAB_LOCUS774</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001114">
        <property type="protein sequence ID" value="CAG5074002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2E1F6"/>
    <dbReference type="OrthoDB" id="2985014at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006820">
        <property type="term" value="P:monoatomic anion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.540">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050382">
        <property type="entry name" value="MFS_Na/Anion_cotransporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027378">
        <property type="entry name" value="Nucleotide_channel_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11662:SF411">
        <property type="entry name" value="GH05102P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11662">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="59"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="134"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="159"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="208"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="334"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="369"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAG5074002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="462" mass="49880" checksum="F3C1F4BB6D13B8C0" modified="2022-05-25" version="1">MAALNKLKRSSVQLRHAALEVCEMADFVRKGSVQLVKRSSVQFKQAAKEVKAAVRARHIVAGLVAVGFALCGAVEVSSSVALLANQEDNHAIIDTSWHCDMLVNISSRNRTEDFEVILLELPQEERAESIMREAFLWGQVAGPILGGCLVWGRSGPSMVFSRAVLGACLASILVPAAWRGPSHVALRLFQGLCTGATMPAAHMDSLCYGLVFIALCWYFTFGHFVKDTPKSYQHDTTGAVIPWGKLLRSVPVWASAVATMGNQWGDATLALGMTKYLKLIYGFSTANNSVLTTLPHIGHFMAALTCGLLVDHVRESGIVSTTTARKLVVYTAHFIPAALLFVAGYAGCQALGAAWLGIAALLIAGSWRLVFGVASLVLLITAAVFLALGKGVPQPWIPSVARPRSHDVIYEQDAFELDYEDVAVQTEPYNSYSLDEDIESNSKDIPRSTSIQSKLSIATSTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2E2I9</accession>
    <name>A0A8J2E2I9_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS1392</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001116">
        <property type="protein sequence ID" value="CAG5075238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2E2I9"/>
    <dbReference type="OrthoDB" id="426210at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5075238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="322" mass="37744" checksum="B0F80194B5F48150" modified="2022-05-25" version="1">MWRDQSSGLRKRVRNSGNDGLSDLIDDKLTWFYNKLQEGIDQYVPVHKCKKDNFPCWFSNELKDKIRLKKAAHARYKKWKSQINYRNFSLLRSDCKKLSLMCYKSYVNRIESMIQSDPNCFWKFIKNKRRNNSDIPSNVFWDDLSADTGTDITNLFASYFESVYIPATILPILEYCSVIWSPYTDILTKQLERIQDKLCKYLSNTCWSRANASTSDDLRKHFKLNNLTNRRQVADMAFFYKVVNGIIDAPDICSSFEFAPANIMLRRKRLLKTTKSSKSYVVNGPHDRIVNLVNKLNGEVEFYGGTFSAFMSNIKRQLLMYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2E4R5</accession>
    <name>A0A8J2E4R5_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Similar to EXOSC9: Exosome complex component RRP45 (Bos taurus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HICCMSTLAB_LOCUS338</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RNase PH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001114">
        <property type="protein sequence ID" value="CAG5073395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2E4R5"/>
    <dbReference type="OrthoDB" id="10264038at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000177">
        <property type="term" value="C:cytoplasmic exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035925">
        <property type="term" value="F:mRNA 3'-UTR AU-rich region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000467">
        <property type="term" value="P:exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071028">
        <property type="term" value="P:nuclear mRNA surveillance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071035">
        <property type="term" value="P:nuclear polyadenylation-dependent rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016075">
        <property type="term" value="P:rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071038">
        <property type="term" value="P:TRAMP-dependent tRNA surveillance pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034473">
        <property type="term" value="P:U1 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034475">
        <property type="term" value="P:U4 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034476">
        <property type="term" value="P:U5 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.70">
        <property type="entry name" value="GHMP Kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001247">
        <property type="entry name" value="ExoRNase_PH_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050590">
        <property type="entry name" value="Exosome_comp_Rrp42_subfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027408">
        <property type="entry name" value="PNPase/RNase_PH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11097:SF14">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT RRP45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11097">
        <property type="entry name" value="EXOSOME COMPLEX EXONUCLEASE RIBOSOMAL RNA PROCESSING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01138">
        <property type="entry name" value="RNase_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exoribonuclease phosphorolytic" evidence="5">
        <location>
            <begin position="31"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAG5073395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="208" mass="23749" checksum="E99F1FFCCA5AA0A5" modified="2022-05-25" version="1">MMEVLITKCEEKFTNAALEENIRLYGRKLNEARKLKLHFGSSWRSFLVSLGQKRVMANVSCDIQQPKLSRLNEGLSNMNVELNLLAAAHFEVGRQSEVGVALTRQLERCFKDSRCLDMEFLCIVVDKKVWNIRIDMNVINHDGNLVDCSRIVSLSVLSHLHRSDITSIRDGVIIHSFAEDLLPLKLFHQPVGVSFYMFENGKTVMDPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2E8W6</accession>
    <name>A0A8J2E8W6_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Similar to wapl: Protein wings apart-like (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HICCMSTLAB_LOCUS503</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WAPL family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001114">
        <property type="protein sequence ID" value="CAG5073573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2E8W6"/>
    <dbReference type="OrthoDB" id="78088at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000374">
        <property type="entry name" value="Protein wings apart-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039874">
        <property type="entry name" value="WAPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022771">
        <property type="entry name" value="WAPL_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012502">
        <property type="entry name" value="WAPL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22100">
        <property type="entry name" value="WINGS APART-LIKE PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22100:SF13">
        <property type="entry name" value="WINGS APART-LIKE PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07814">
        <property type="entry name" value="WAPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51271">
        <property type="entry name" value="WAPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WAPL" evidence="3">
        <location>
            <begin position="622"/>
            <end position="1136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="83"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="127"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="380"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="463"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="553"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1037"/>
            <end position="1062"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="83"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="150"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="256"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="291"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="304"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="395"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="464"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="496"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="565"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1037"/>
            <end position="1052"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG5073573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="1187" mass="131509" checksum="6F2FA9A1C948899C" modified="2022-05-25" version="1">MTSRSYTKSFSRKVNSVTPGSIQFDKLFRESSNRPSAAKSAGTVGKWGITSFTSIRSTNINGRKNEIHKTFGTKRMKLDYGNQNAQVNTPNQDPFSFDTDIDPKTDSPVTASVPTVPVVKPKKFFKSRNAPTVDPTKLDYNRQLPVPDHPQSAQQPARPRAQKQPAPAKLVSKPYTPVRKISESMDSSSSDTSTREDGKPPIVLRICKGTARLVSGDSKEVTESEPDTYRITPTSPSKDSVKSSPEIPAKDLKSLSKLQTTQPTVTTVSIPLDEDVPTRRTTRSRAKNLNLDLTPTLSTSVSLPGSSPASAQNSSSSSGLSLTLRKSITDSNNTLISHYDIVKTDCPSYQTKTPVVEPLIGRNQPLPTTTQELIDILSSEAAGDSSVRPIPAPEPDPEVSDPQEESVGEEQSSIDLPTTLPAEFQSEYHQLEPEPVTGFASTDYSHSTHEELTYPVYNYPTESTEAKPDNEYNEERPAAKTLVDQDWFSGSEDSETASGNTEMEIQTNEPSSVSVEQQPAATKPAIKKGSIFKSRSAGATNGNKRRALYKHKWCDNDKESNTPESTVASISPPSAASGSTSGGPNVTFDEIEDETLTRVVTYPEYDTEFGDDAEAITSIRCGKKVKGFYTVVKNVKKAHQIQESGEFQEFNDDVEYILDTLRENNPNATRCLSAIRLASKCMAPAFRMHVRAHGTVAKFFKALHDATKDQSLGLCTATVMFVLSQDRLAMDLDRDCLELMLSLLESDASHKDALDDCGLSRTELQKNKEKVRQLCADIQAQGHAKHLNLDNITVGQLAMETLLSLTSKRAGEWFKEELRELGGLEHIVKTITDCYRFIKASNVTRTGWSEPLLDKLRKVDRCLRVLENVTHMNEENQVYLLNYEMGILVSTMVSLYHLCGMEIVIYPTIDVSDKTSTGAVIRECIFAILKVLINLTHRFNRQSFGSKSVGSQSNVLDCSLNLLLRVPDSLPEEKRFDMMILTLILLINLIEQCDDNKELLIKSQAPLSPENLFDHQEGGVDALIDLFYKQEEMARGEEQKTDDILDGKKDTEQPEAVSTPAKTQEEFIAETVAKLLQKASRHMEHTMIGAHVVLLLGNLIMDNIEYETLVRDKLPDHNFSLMISILQKFYNFMNLTTSSEASNFGIHATDKVLKFLKLSDARVEEDKNALPLPALEESSIMLDLSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2E9Q7</accession>
    <name>A0A8J2E9Q7_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HAUS augmin-like complex subunit 6 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS973</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001114">
        <property type="protein sequence ID" value="CAG5074229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2E9Q7"/>
    <dbReference type="OrthoDB" id="5575722at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028163">
        <property type="entry name" value="HAUS_6_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14661">
        <property type="entry name" value="HAUS6_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HAUS augmin-like complex subunit 6 N-terminal" evidence="2">
        <location>
            <begin position="8"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="150"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="268"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5074229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="476" mass="54260" checksum="8B80B372D5EA37C7" modified="2022-05-25" version="1">MSKDLEKLVSPTMFEQPNTTGFILLSQYLLSTYDQERFEQAVQWPLLNKTEEGRYRTQVKSFIGTVFEENDDFTMSSIQASHLHTAHVIDKTERYEDIEKRAVERMKETSERITKYNEKIFKLKPELAEIVAKSDVDEDLKKRLVDIKDKEAIKEMARDTYAKIEELRKKVDEQDELMKYAEEVNALVKSVCGQDRVILDGSKLPKVDLDKLSKCPLNPEARVLVQKLYNEDGHLVLRNWLVVFKAVLNCSRNTLSQEEFTPEDNELIKEQTEVLKRMSEELSQIQARMKELADKLPKEQLQPRAPDDGKILNLSLELENLGLMTEKRLLLTPNTSLPAMFLKTDVSSPLAGPSTSNVKDLQIPKLKFDDSIDLGATEKKSLPPNLMRLFTGSKSDLMSTQSTSELVRNYTLNMSSSFCSLGKKSSLKRVLSSNGSLLDQDDAKEDKQCDSSDEIKSMADILRKYKADGDTSKFSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2EAX5</accession>
    <name>A0A8J2EAX5_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Similar to NIPA2: Magnesium transporter NIPA2 (Pongo abelii)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HICCMSTLAB_LOCUS235</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NIPA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001114">
        <property type="protein sequence ID" value="CAG5073232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2EAX5"/>
    <dbReference type="OrthoDB" id="6428174at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008521">
        <property type="entry name" value="Mg_trans_NIPA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12570:SF92">
        <property type="entry name" value="SPICHTHYIN, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05653">
        <property type="entry name" value="Mg_trans_NIPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="74"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAG5073232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="118" mass="12924" checksum="A6FBA7EF4C598538" modified="2022-05-25" version="1">MEYHFSNWDFNIGIILAISSNIFIGASFIIKKKALIQLQRYGIRAGEGGHGYLRQFTWWSGLLTMGIGEAANFVAYAFAPASVVTPLGALSIVITSILSSKYLNEKINLLGKDASFAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2EBB5</accession>
    <name>A0A8J2EBB5_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HICCMSTLAB_LOCUS885</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001114">
        <property type="protein sequence ID" value="CAG5074113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2EBB5"/>
    <dbReference type="OrthoDB" id="10036464at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038757">
        <property type="entry name" value="BRAP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35259">
        <property type="entry name" value="BOMBESIN RECEPTOR-ACTIVATED PROTEIN C6ORF89"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35259:SF1">
        <property type="entry name" value="BOMBESIN RECEPTOR-ACTIVATED PROTEIN C6ORF89"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="52"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAG5074113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="318" mass="37670" checksum="D2C9E11B08F506E1" modified="2022-05-25" version="1" fragment="single">LKMINLKNYCNYIDQIKKYAKRSDISETELEKIFDECFDDIEKKFKKNKRGICNVICKLLQLFLIVNFLLLLLLIVIYHDPHLRSFFLRNLQSYIYPGFYIFRKLAVPVITRYPTLTEYYDETCLVENPFFQLSSIDCWPCNTIQTIPDMSGLNWSIPRNFNFGFPFIRQENDSINNLSSLFDMLEINKDIFINDARRISSNNIDYQNINDVINKRLDINKSQLGKTHISWRINRMTPGRIIRKLFPKPKGTPDWWGQSVERFIFIDEPLAPLYNLSRVSKHLSAYRDNFKSWLHLMVQLVVLETNQLPSDQCNGSFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2EHB3</accession>
    <name>A0A8J2EHB3_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Pattern recognition serine proteinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HICCMSTLAB_LOCUS1672</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001116">
        <property type="protein sequence ID" value="CAG5075518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2EHB3"/>
    <dbReference type="OrthoDB" id="2019384at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00033">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00112">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.70.10">
        <property type="entry name" value="Complement Module, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.400.10">
        <property type="entry name" value="Low-density Lipoprotein Receptor"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036055">
        <property type="entry name" value="LDL_receptor-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023415">
        <property type="entry name" value="LDLR_class-A_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002172">
        <property type="entry name" value="LDrepeatLR_classA_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035976">
        <property type="entry name" value="Sushi/SCR/CCP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000436">
        <property type="entry name" value="Sushi_SCR_CCP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24252">
        <property type="entry name" value="ACROSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24252:SF7">
        <property type="entry name" value="HYALIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00057">
        <property type="entry name" value="Ldl_recept_a"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00084">
        <property type="entry name" value="Sushi"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00261">
        <property type="entry name" value="LDLRECEPTOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00032">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00192">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57535">
        <property type="entry name" value="Complement control module/SCR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57424">
        <property type="entry name" value="LDL receptor-like module"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01209">
        <property type="entry name" value="LDLRA_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50068">
        <property type="entry name" value="LDLRA_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50923">
        <property type="entry name" value="SUSHI"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0768">Sushi</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035147175" evidence="4">
        <location>
            <begin position="24"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="6">
        <location>
            <begin position="229"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="6">
        <location>
            <begin position="302"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="5">
        <location>
            <begin position="387"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="27"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="34"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="70"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="77"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="121"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="128"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="162"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="169"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAG5075518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="672" mass="74044" checksum="AD986A947D315D95" modified="2022-05-25" version="1">MNLKVRCVIFSIQILGLLQLSHSQDTCELNQFRCANEQCITGEFLCDGKQDCMDGSDETRHECLKTEIICPQYAFRCDYGACIDGDALCNGVDDCVDKSDEKSSRCRGSITNASVVNSGNCGVNQFKCNSGQCIDDIVVCDGSPDCSDRSDETSATCSSHQCPKFTFQCAYGACIDGDKKCDGIRNCVDGSDEEFILCSEKKIAISSTTQRTKNQVTSTTSSPWIQPQSICFPPEQPQNGRWKLHKSQCQSNEHCDANQNTVMIPGTYLVYSCNPGYELKGSSDIFCGPKSKWSSEPECVEIRCKPLSSVSTVAECDNNNEWISCEMPVPPGTSAKISCRDSYRQDTTVLGLQRDIVRCNAKGQWEPKPIHCIPVCGIRSTSLNPLIVKGGTPNISDFPWHATLYKSESRYDEKLFICGATIIQNDMLITAAHCVYNEEIQKVESPEKFSIATGNIFRDFNSLLHDSRLVHKRNVKNIFIDCNYSGNKGRYTRDIAILQIDKVFTFTQFLVPACLDITNNDHIAIDVGQKGSVAGFGRTELGPSSGMLQSLTVPVVPLSHCKSASLSNESDVYTTLDKFCAGYTNGSSVCNGDSGGGLVFNNQGLWYLRGIVSVSIGSKISDGIPVCNNNLYSLYTKISSHMSWIQDIIFKLETHKNIPPCDTASDFSRRLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2EHC9</accession>
    <name>A0A8J2EHC9_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS63</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030000495">
        <property type="protein sequence ID" value="CAG5071461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2EHC9"/>
    <dbReference type="OrthoDB" id="10027416at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5071461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="60" mass="6522" checksum="E98226F0D9D1EABF" modified="2022-05-25" version="1" fragment="single">IRGKLLDPKARSVQLSKLLPNTQYLICVLGLGNWMTPLPEDLGTNQNSTDDLINTGSNLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2EMN7</accession>
    <name>A0A8J2EMN7_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Similar to Timp: Tissue inhibitor of metalloproteinase (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HICCMSTLAB_LOCUS924</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001114">
        <property type="protein sequence ID" value="CAG5074152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2EMN7"/>
    <dbReference type="OrthoDB" id="6041373at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008191">
        <property type="term" value="F:metalloendopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002020">
        <property type="term" value="F:protease binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051045">
        <property type="term" value="P:negative regulation of membrane protein ectodomain proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.120">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001134">
        <property type="entry name" value="Netrin_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001820">
        <property type="entry name" value="TIMP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008993">
        <property type="entry name" value="TIMP-like_OB-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11844">
        <property type="entry name" value="METALLOPROTEASE INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11844:SF33">
        <property type="entry name" value="TISSUE INHIBITOR OF METALLOPROTEINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00965">
        <property type="entry name" value="TIMP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50242">
        <property type="entry name" value="TIMP-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50189">
        <property type="entry name" value="NTR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035155975" evidence="6">
        <location>
            <begin position="21"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="domain" description="NTR" evidence="7">
        <location>
            <begin position="21"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="NTR" evidence="7">
        <location>
            <begin position="164"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="21"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>ligand shared with metalloproteinase partner</note>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="21"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="23"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="33"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR601820-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR601820-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG5074152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="288" mass="32370" checksum="BAAD7496F3E3DEB2" modified="2022-05-25" version="1">MIHVLFLLTLSLVAIYEANACSCVYQSHQQKFCESDFVIKMKVEDIKENNKESQYLMYQVNILETYKASAAAKSALKNRVLVTYSDSGICGIPFWRDDVAVVSGFVINEQPHISICDMHIYNAEKIAAEEMNLRENYIKSCVSMMRFLFFLTLSLVAIYEANACSCAAFPLQHLFCESDFVIKMKIDDLPENKESSYLMYKVDILETYKESDAAKSALKNRLVATNLESGICGLIYKQGDVVVVGGGIMNGVPHISLCELHIENAEKIAAEETNLRENFIKTCVSVVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H036</accession>
    <name>A0A8J2H036_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS1474</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001116">
        <property type="protein sequence ID" value="CAG5075320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H036"/>
    <dbReference type="OrthoDB" id="9974479at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="453"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5075320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="551" mass="63331" checksum="48940127CDB49B34" modified="2022-05-25" version="1" fragment="single">YHDVAVNVSYSKMLSSMRTSRKKRVFPDFHSYSEFRDLLYSEDWQQLRWYDGTSTVEVTVHNSGEENESLVYSSTMETCNTLPAEELLVVTSILEKKAFLCFFALIKTKDNNCYREIINQLVTILPTPTRIFGNFNAELHHHLETVYPNAEIKGSFYSYCNILFQSVTDFGVFQNEDNEIFVRKLMALALLPDNKMNIVYTAIKSAIPDNQKNIYQNFLLNFEEKWLRNVGPHRISCFKNMLQLSTVPRATANVLMNSKINNQPVWTMLEFIGTIFYKNEINIKSLRDGKRASRKTCLQLDYLISKNVMDRIVKNLKGRHPNYAVFLASASFQLKDSFQTFRHNYEKRVIQSDNLLPLIGDNLPDDNVNVITLTAQELFLEINPDSAPTRNQLNNDHAAEHLLLNAEPLNNDFDIGDQDAAHEEIPDDPWNAIELPLIAEDMVQEMVEPEETFEDFEMLLEEYEEDLDQLTKNNAAVPQTNEVVSNSVLNIEAAADESFILESEVLGIINPILMDDQNCVECKIKTAECVMLPCLHFNLCYSCSSQKVQQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H089</accession>
    <name>A0A8J2H089_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS1719</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001116">
        <property type="protein sequence ID" value="CAG5075565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H089"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5075565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="245" mass="28692" checksum="A55C96D26661EFDC" modified="2022-05-25" version="1">MISLPDSSQKKDWVFLNSLSWVGTSVPDHLLKMILKAALPIIAKNYFTKQPVLEAVLYSSVEESFNASADYSYFFVKAVIRETNCPATKNIDRDAYKECFEQNMEGSLKLCAIHMYYKPATEEFRKNIIKCWKMNNPSLKDDYYTDKALEAVEPIINRQIINEHHYYASFHMESIDRIYHLDLKTPEIWYDQIFYLKFQIQQCLEPLDNKCISPDDESNVLTCSGEIDVSSKQPDLYEEYMFDCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H442</accession>
    <name>A0A8J2H442_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">28S rRNA (uridine-N(3))-methyltransferase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Centromere protein 32</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Kinetochore-associated protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">SPOUT domain-containing methyltransferase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">HICCMSTLAB_LOCUS2086</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="11">S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the N3 position of a uridine in 28S rRNA. Required for association of the centrosomes with the poles of the bipolar mitotic spindle during metaphase. Also involved in chromosome alignment. May promote centrosome maturation probably by recruiting A-kinase anchor protein AKAP9 to centrosomes in early mitosis. Binds specifically to miRNA MIR145 hairpin, regulates MIR145 expression at a postranscriptional level.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>uridine in 28S rRNA + S-adenosyl-L-methionine = N(3)-methyluridine in 28S rRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:83635"/>
            <dbReference type="Rhea" id="RHEA-COMP:20178"/>
            <dbReference type="Rhea" id="RHEA-COMP:20181"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74502"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:83636"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="6">Interacts with INCA1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class IV-like SAM-binding methyltransferase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001116">
        <property type="protein sequence ID" value="CAG5076105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H442"/>
    <dbReference type="OrthoDB" id="361029at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18086">
        <property type="entry name" value="HsC9orf114-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000170">
        <property type="entry name" value="SPOUT domain containing methyltransferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003750">
        <property type="entry name" value="Put_MeTrfase-C9orf114-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12150">
        <property type="entry name" value="CLASS IV SAM-BINDING METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12150:SF13">
        <property type="entry name" value="METHYLTRANSFERASE C9ORF114-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02598">
        <property type="entry name" value="Methyltrn_RNA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="alpha/beta knot"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 14" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="32"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00062137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00075627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00078957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00079311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00093228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00093377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00093639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CAG5076105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="378" mass="42596" checksum="50C40F4C2648BE8F" modified="2022-05-25" version="1">MSTVVPMGKNFKEHNKIHKENRRKWREERLMKKMATSKPTNSSPPELESNPAPEVVKKVVPTLSIAVPGSILDNAQSQELRTYLAGQIARAACVYQVDEVVVFDDQGEITELERHSKKVKVETTWQTEGEGEGSSANLAYRRACLQLARILQYLECPQYLRKYFFPIHKDLQFAGLLNPLDAPHHLRQNDYCQFREGVVVDKPLKPGRGSQVNCGLLRDVEIDKTISPNLRVTVRIPEGIEGKKIKGQVVSPRTPKENGIYWGYSVRIARSLSEIIEKCPYKEGYDVIVGTSDKGKSVDHLDDGALVYRRGLIVFGGLAGLEAALEADPKLDLEDPKLLFGEYVNTCPRQGSRTIRTEEAILISLAEMRKKMVPWNEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H5E2</accession>
    <name>A0A8J2H5E2_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Similar to RIF1: Telomere-associated protein RIF1 (Homo sapiens)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HICCMSTLAB_LOCUS527</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Telomere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001114">
        <property type="protein sequence ID" value="CAG5073620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5399929at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140445">
        <property type="term" value="C:chromosome, telomeric repeat region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14267">
        <property type="entry name" value="Rif1_CTD_C-II_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022031">
        <property type="entry name" value="Rif1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22928">
        <property type="entry name" value="TELOMERE-ASSOCIATED PROTEIN RIF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22928:SF3">
        <property type="entry name" value="TELOMERE-ASSOCIATED PROTEIN RIF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12231">
        <property type="entry name" value="Rif1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0779">Telomere</keyword>
    <feature type="domain" description="Telomere-associated protein Rif1 N-terminal" evidence="8">
        <location>
            <begin position="250"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="927"/>
            <end position="951"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1005"/>
            <end position="1363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1016"/>
            <end position="1030"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1074"/>
            <end position="1096"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="1097"/>
            <end position="1108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1112"/>
            <end position="1126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1142"/>
            <end position="1154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1170"/>
            <end position="1187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1194"/>
            <end position="1220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1269"/>
            <end position="1283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1321"/>
            <end position="1336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1348"/>
            <end position="1361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAG5073620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="2215" mass="248835" checksum="825841E3FCB5F093" modified="2022-05-25" version="1">MTSTSLTPADVLAKLQGTIPSTDEIIILTYINSDNKRTNLLQIMTDNQYSDLCNLIINFMTSEQESGLLKKSDVKSLLNNIFNESNKKMPFFRLSLTVGRNKRLKIFDLIKTVEDKQLTRLVDDQDTCKFLNDCLTDVEASKMEWLSPTTCTDNISLLVQAEKKPTDFEDLVIYSALEFIHRLYKHSLVNSNFNIRKFHQLVLDKVITLLYMGHKHQRARALDLFTTALKTDLHSYIRQHHEETWTVYRSNLQNVYHIRMLSLVKASQPDWCRQWCLSVQALGTDLHRGADLINNLLSVEERAFKSPDMSIRIQAFQAWKLLIENFAIDPTQLAIPRRIKLLCIPLNANNNKTESIALAKFEVWRHLIIKLSSTPDKSLTQVIAQFLNFCFGPLGDTPLLSTKSGIQSSPGKRFVKARKCAVDSLLQLLASDPQDRALLFPELDQDNTTINVISQEMFQENFKSYIHSSGEACLLINDSEFVFENRETLNRILWQSLMNLINKSTDELKPKMYQELILIICEVVNHIRVRDDCTSNLLLDTIVPELVKVSSHLLYRDQTLMDLLIRLLDPEFLKRPNAGLKTLLVHAIKPEAITGYHPESLPFLKSVLSQMIALGTNVNLTGFVIEIWAELAELFVKFMDKESINEGTTLAHNFDTAYSLIIFPFKVKWINSNDVNQLIKISRCWKDLYAKFNNAADLITTVKTNEVLDHVAEDLLTLVSARDNNKSYRFICYVFDALMNTIHYSDYLAVEGVPSLTSLLRDVTYSTLEQAEYVNEIECSLKAMASLLITIYGLEQDKAQFHLTVLKPCIEAMLKINVPECVKEVVNTWETVVIILKGLWSCLTSEFIDSYREALVNALCHTNHEIAAQTMTFLDHSEPIGEDVKQILNEIELEASKKMSSLVKSDEGEKKHVRVAGSFLGRKSITKVSGGKKGKEKRMTPVPVPPEPDSQDYVLIQNDVKVNVNLLTEHQKECFKRHRDDIPAMYNDLSQSGSRNTQELEEWFKNKAGGSTETTDDNKENKHEEVKESEEIVGDTQELSPEAGDKIEEGSVASIVKKLNFESRDEFPDENENTQDKDLTKLGLHPRDGAGGSRRDGRGRRGRRRGGRISRSSRDQEKGIKRKSVDSEEYADPKRRRHSAPTDLQSDSESFCSNDSEKSPDGRTGVSQRTQKEMSRLKIDMVFDSRKMSKLRNKVSEDQKSKSANDDFVYEKVNKRHSLDPSKLVKKTTRSSGDSMLVERQDLIFVRRKRKIYPKPQDPQNQEDSKFLSPMSSPSTSTTSNSTADEVVESSQDLCSVRSPRRERKTDKVEVANDENQVPEPALSSVPASAPALDSPIKTDVPPEPVKSESPVKSSQEVVEPTVDVKEEEAKAIFPSPKVIKRLTKPKLLTPGRGAHMLGLVTNLGMSETEEIKVSRVKPKDSEVPVSEILKKERAKDLGGSPGGSRQRKIFSNMKTGDYTSSPTKLFSNLKNDGEKISPKMEKVKDVGKTDHDYTELKEVQIDLPMLEWSSANPPSLTASPSAGILKKRAVSALNYAIFNSTGNSNVNNVPVGNEEMVDTPKRKRVSFADPPVSKEMGYEVLPGSPGKLTKLFMTRSFPGRKDTPLKIKLPKFKTIQTEEKPVEALKSDTRLYDINIEDKEQEDVEVSIASQDIFQGEDMNVIVEEKNDSLTPVVEEYGTQESTMGRIMNGTASQMEVGSINNINETLEDTVDVGNISTFTDDSIYKPVRTSTVEKINASDTLPVTSSIFDSQQSVDLTQGQGMEMTDPICPTLLGCTEPIDSIVDNLVHPLWSKNLSKLFTSRNINTVGDLAALSSLEYEKLPLKASGSPKVEHVRKVLTDFSMSLSTVSADREEIMDVDSQLNHSLIEDVGTQPVVYNDDLNISEVLTDKIRVTQEIERTEEKCSNEFGSIILDNTLSPPKKSSTGMNSGLMNAVSGKKDVEVATDSLATDSKSVGVQMKLDELLDEIDVDLVLASGAKMGAKNDAELGRETMHLLGMETYPDTCLKIACRDYGASKILGRLPDIFINDKEFFSKVLNTYRMKLTTSDLLSVADIDSVKQELCQKLTSAELCDMLAQVLAEEEEREIKTPITDETCLNSILKRMPIDSVISHTVANDELIPSSVVLDIALQNNSPDIIAAALDSHRNNNSIKEIIVNKYLTSDKLLTYLGKKQADLSKEKIVDIYRSVCDKLTIEELLDLNNKIIKEKLKQLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H5P8</accession>
    <name>A0A8J2H5P8_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Gustatory receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HICCMSTLAB_LOCUS1462</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Cell membrane</location>
            <topology evidence="1 8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the insect chemoreceptor superfamily. Gustatory receptor (GR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001116">
        <property type="protein sequence ID" value="CAG5075308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H5P8"/>
    <dbReference type="OrthoDB" id="6366728at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030425">
        <property type="term" value="C:dendrite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043025">
        <property type="term" value="C:neuronal cell body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007635">
        <property type="term" value="P:chemosensory behavior"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008049">
        <property type="term" value="P:male courtship behavior"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050909">
        <property type="term" value="P:sensory perception of taste"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013604">
        <property type="entry name" value="7TM_chemorcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21143:SF133">
        <property type="entry name" value="GUSTATORY AND PHEROMONE RECEPTOR 32A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21143">
        <property type="entry name" value="INVERTEBRATE GUSTATORY RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08395">
        <property type="entry name" value="7tm_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 8 9" id="KW-0675">Receptor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="54"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="83"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="139"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="174"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="257"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAG5075308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="411" mass="47919" checksum="B8431A65B5D23367" modified="2022-05-25" version="1">MNLAKLSKSKTLPIRLLIIFFKVSGFAPFKVSVLPKPFFKKRSRIRLLYSPKGIVYNFILSLPMIRLLVFSIAKHNAEDPTYILGKCMVISSAFAAPVILGYYCIKQGAIIEVLSRLLKLEDDLLDKFNRSVSRLHKSITYETVVFVIYISLTSSHVALTYFEYPGLWKRSLVTLFIEITINNLIFQYSLIVYYINKRLNYMNELLLSLSKSDNNRLKNEVTFLTSSSHNEMILKTIVLIRELQRSLYDIFKEISKFFTWPIFFAMTIFCIRMLLYAFKFVKRLILHPEETNVVIFIKCPISVLKEMFIIIIMARHMTQITVEMQKAGEIIYKIMDIYSTSGKIQSELEQFSIEILLRRIPKSIFGLFTIDGSHVAMIVRSTITYVIILVQFNYNLHTQYDGNIVPDKYRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H611</accession>
    <name>A0A8J2H611_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Similar to Ddhd2: Phospholipase DDHD2 (Mus musculus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HICCMSTLAB_LOCUS2536</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PA-PLA1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001117">
        <property type="protein sequence ID" value="CAG5077702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H611"/>
    <dbReference type="OrthoDB" id="69269at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030134">
        <property type="term" value="C:COPII-coated ER to Golgi transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004620">
        <property type="term" value="F:phospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004177">
        <property type="entry name" value="DDHD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058055">
        <property type="entry name" value="PA-PLA1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004170">
        <property type="entry name" value="WWE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057825">
        <property type="entry name" value="WWE_SEC23-DDH2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23509:SF10">
        <property type="entry name" value="LD21067P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23509">
        <property type="entry name" value="PA-PL1 PHOSPHOLIPASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02862">
        <property type="entry name" value="DDHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02825">
        <property type="entry name" value="WWE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23464">
        <property type="entry name" value="WWE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01127">
        <property type="entry name" value="DDHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51043">
        <property type="entry name" value="DDHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50918">
        <property type="entry name" value="WWE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WWE" evidence="3">
        <location>
            <begin position="403"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="domain" description="DDHD" evidence="4">
        <location>
            <begin position="804"/>
            <end position="1029"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="276"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="940"/>
            <end position="966"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1048"/>
            <end position="1107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="276"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1048"/>
            <end position="1070"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAG5077702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="1107" mass="123841" checksum="82338A488E835804" modified="2022-05-25" version="1">MSDLNRKMKNPLLTAAGQGFPFEEHEIPNLLIPVAQPVLTSQDGNANPTPFPSGNDVLSTIELDNRDGSNGTITKTETLSEISLNDQCYDESSSRSLTESIDSLNLTSNPTTPPLSFPIANTIQNSSYRLGNQRRLRYVPPPNLTSSHQAPLQPPITQPFTPAPAPVSQEIFTPTVNQPPQAQHVPSAPPVPAEFAPAHVQERVPLVQPNLPQVPVNTPPSGLSNYFSASNQDNDIFSSCYAPPQTQNLLSNFNAANEAFPRNQSTNSSVDVQSTNFYSSNINSPFTRDESDNEKRDLVTVDHRGPQDPIKLEDSSATQSNLSVQSTFYNPANYNPPCQVPTPPSFSFDSVHASPGLEQPAFVNCMMPEPTGSATLNPTQISVSQLAPGRVHTETIIPASLENLASANKIMYRPVYYHWFHCREIETKIIWQPFSMHDSLNLEQAFNSTEISAETVIATDGGRYDVEIIKRQRRPVYWSATPTQVRRCSWFFKGPTESRYTPYEEQIAARLEEEYKQACLSNSWNRRVELSNNEHIIFHSATVQVHYTPATSLEFNSSWSNSYNVANRPKLVKRGLDELNIDEGEPEAIDHLLFLVHGIGSACDLKFRSVEEVVDEFRSISLQLVQTHYRTETDHGRVHRIEVLPISWHSTLHSEDTGIDNKLKTITLESIPKLRHFTNDTLLDILFYTSPVYCQTIMQAVGNEMNKQYALFKERNPLFNGSVYLGGHSLGSLILFDLLCHQKPIVDKPKEDVTSENENSEDEDTVGEMQTIPRAKFERRTSRRISYVMGSAGTGQPFIVYPHLNFYPKAFFAFGSPIGMFVTTRGIDNLGSDFRLPTCPAFFNIFHPFDPVAYRIEPMVNPEAYKYPPQLIPHHKGRKRMHLELKETMARVGADLKQKILNSMKVTWNSVFQLTSFYQPDNKALEQEIEKVVEEEFKKSSRLAESSANSNNDKNEDNDSSEAGRYYHDDRLSDAGEINIKMGKLNGGRRIDYVLQEAPFEYINEYIFALTSHVESEDTMLLILKEIYGSNGIQADAQLPQQLLTPTSVSFSSSDSLSSPSHELPSTSASHPHPLSTSPALQGVDPTAPITQKSVGPPPISGFVRKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H6M7</accession>
    <name>A0A8J2H6M7_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HICCMSTLAB_LOCUS2813</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Rough endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001117">
        <property type="protein sequence ID" value="CAG5078691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H6M7"/>
    <dbReference type="OrthoDB" id="6517071at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030867">
        <property type="term" value="C:rough endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0023041">
        <property type="term" value="P:neuronal signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019130">
        <property type="entry name" value="Macoilin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13289:SF3">
        <property type="entry name" value="BIFOCAL, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13289">
        <property type="entry name" value="PROTEIN PHOSPHATASE 1-BINDING PROTEIN BIFOCAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="153"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="526"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="726"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="776"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="23"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="792"/>
            <end position="805"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAG5078691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="821" mass="89776" checksum="63A9C447A0051474" modified="2022-05-25" version="1">MATDTDNIPQWKLELIQRRKNKPVVSSPGGSSSSTCSKAPHSSKVTTSKINSSGSASASEIPQVLKTATGGVPSQQKSEPGVGQKSVCCKMRLEPDAYLHPDGSDCEELAYGPGIVNRLRCKYLNLTKENLTGSNFRRAASLEDLLGDDTRKFVKKSPAPGPGPGISPGGVALRTERFRNPSRGNDSIKRARSVETLMRYDLQDPDIILVDNSVKIESKLTPGVLKPKRLRPVLAETERPPPDLVKTTMRIFESTVKKVKPRGEVAVKVATFKGINDSMKGKKVVKVGKVITNSGKAPGKVVQDGVVVEKIVKVSQAVSKFQQISGEISGDKKFEKKVKGKVGNFEEEPFDGRKVGDILGKVRIFEEEIFDGGKVGNFEKVVNFIPELIDNGKLEVNFEENVENFGKVIEKLETFEEGNLNGKVLAKSDEWKILEESGKKLEILENVEKLQRFEKLEIVENFEEKLEEKIKIDVVDTSEKLKENETEDLGVKKISKKSQEEISKAGESVKFDFNDNNEVKNYLPGVNGGSEEKEVKTNGNGVEKNSSKGKEPKQIGIIRPLVSSKSLSSRELEKNLINRVKSIESEPTKVVVSLKNAEEVKNGGLWDKPWNQQNNTMVFNFSNRKDVPDYIENDGLIIRRKREKTKGDGIIVLDATLDASTTDDGDWELSGGPPSPCDVAFFNDNVLINGRSNLSRSPRNHKHRIQFNDGATKTFEYPSEASMLEDEGTCVDGGTSSGSATDRPDSGNLGNSGGLVTTVESQAQLQQCNIGSAAANPILVTRTVAPPTEADPPPEEPPPEVEEPSSESAAWGAEATADLLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H6Q2</accession>
    <name>A0A8J2H6Q2_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS2994</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001117">
        <property type="protein sequence ID" value="CAG5079367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H6Q2"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="entry name" value="Intergrase catalytic core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="DNA breaking-rejoining enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="73"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="73"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5079367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="129" mass="14344" checksum="BD0712E38F1C3352" modified="2022-05-25" version="1">MSSDESGAELRCHSKKARVLTLSQVNKFLNDSDDLNNLANKVILTFRVLGALRTSEICNLNIQDIEDTGIPSATITNEAPSTSTANQNNPKTNLNDDDAQFTVTINDSKNCFLRNFTVDQEYYGIIHNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H6S2</accession>
    <name>A0A8J2H6S2_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HICCMSTLAB_LOCUS3039</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001117">
        <property type="protein sequence ID" value="CAG5079546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H6S2"/>
    <dbReference type="OrthoDB" id="8050739at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00303">
        <property type="entry name" value="retropepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="183"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="52"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="125"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="228"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="228"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="256"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG5079546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="1064" mass="120268" checksum="DA432A042BA63F8F" modified="2022-05-25" version="1">MQSKYWEMKTPPPVKEQVEVIQNHLPNKLRTLIFSRAVEDYDSLLETIHKASQSNEENSRLFDSSAADKPSTKPKEKTRLAALQDLPGTKVSILTGNQTFPLVIEEIREEAGGLVVCASASNAPQSYARNNNQPRHSQRNQQQGNRVSYPYANNNYPRSYEEATNNMDNNRQTTINSPSGDFCFNCGQYGHEFVACTNIQIDVCTNCFRSGHDRQNCHKLFGQAQSNPPAVGSNNSFYSQSGNHPNFNPRNRSNRGRVNYSYNNSYNNNNNNANNNQSSSSSNQPSVILKRNKSEEVNLIDLESDESRALRSECSPRSGSDESRAFGPEISNLLSGSDESRAPDLITIGEVRSDEKCASTSEIIIAEARSDETRAPTSDLLIWEPESDESRAFGPSENYATGESVQFNCDIDNCFNDYCKIYDNLSGLCVFKNVEAQTYLKEGLKVEARLLSNSKSPETFMSTGDFIEEVFNNFGTKELTNLSATTICQSVKLLDETRFDHEVEDIGPDELIEPSAVDNVKAYYICGLEPLDELQEEEWEPEVDSGIETDFDEPDFRIIPPLSRCSALSKTFHASGMLRGKGLPAHFINRLTPCPPYIPKTESKLTARIPVSLWVFGVQVNGIIDTGSERSYLNTETFEQIQEYGTSDLHQDDTAKRGVLLANNTSCKTLGGADFILQIGSVTGQQYLSVMEDLSHSIILGMDFALQFGIESDCVNAHWKFKDSSEVYPFEIIERKDDKTLCQILSESQRKKFEEFLRFEMDKFAAIPNQEPRLSGKPSRVEIEDLDLDSEAWKARIDRLDQLRHKVELVMRKESERQARYHDKGLKSLPEVQVGDQVYYPNRKQQEREQQVYDLFYRTPGRFKTMAQVRTHLRSERRLVAHRRLLRDFDPPFPAHLLKLGWEYHRPSTKLRWLSTVHKGNWSRFTIEGADPVAPAVAAEEEPVVKVVPAPTGLEDNDGDVLYIDEEVDLGEDLLDDLVPTRASHFKSNERPRIVVSLSLNKFETVTRHAAQRHRSSMETLAKRAKTSSRLAPAVQQGVLEPWVVLTPVDGSHLARTPMRGRRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H7I5</accession>
    <name>A0A8J2H7I5_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS3217</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5081200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H7I5"/>
    <dbReference type="OrthoDB" id="10297163at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="95"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5081200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="119" mass="13574" checksum="0D28AD0732F6414B" modified="2022-05-25" version="1">MQPDNDPRLPTYAEATRAQVNHAHEHYPTTYPAYTNPISPYTTSELPNYSHPPSVPLYQYENNQLPTNTPAAQRIHIITEIVPQSRSVSCTRRHGIFWGIVFGLLIFAGILRVIMSYHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H7Q5</accession>
    <name>A0A8J2H7Q5_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS3395</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5081855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H7Q5"/>
    <dbReference type="OrthoDB" id="10041077at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14924">
        <property type="entry name" value="MAP10_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="239"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5081855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="602" mass="67653" checksum="9018FD57BCD246E1" modified="2022-05-25" version="1">MSDQSSSKEQYLFLLEFFVHYITGERVSKLNETLRGPTSILLQFLGIQNDAIEITPAHQQLSPLARPAIGARDVEKFYSGRSILFAIPQTVVVNKNAEFKINLRVYKKMPADIHPDVLIGTGELDITNEFTGLRKEMFDCWNCDVPPPKNYEGPVEIYHNNQLAAFVLAYVRISSFGQSIVTAFDAPATKTGSFIFRSEFMDQEALAYNCRLISQSLFNLKARQRSNLQLDPPFCRENYCPHQDGGDKDSGGENKAQARGFESPAPFSQPLVLKVSGMIDQEGNFNDACHQDADFDVFVLRIGKKGLVGEEEKSDIQIELRTPKALVDTLPVRCETREIQTEAEEAKFDEEILVRKTSKKKKQKLFLIEFLVDRVSVPTVRAMHDEFMPAKTCVSFKILSLPAVNIYQEDPVSGARSDNFFRKGKSCLFALPNLVLEKPLHTFPVTLSVYKKLPAGVLPDVMHIGAHQIEMKELMNGLLREHVFRGSDASKSLKNTYTIETATGQVVGNVTVFIRTSCFGKKLVTQFEIPHNRKPYLFKSLDDSSVFECQRISSSVASPGFSGKKSTSRRDNIDARNCQASRPLGLFESSYKPTLTFNKTSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H7S4</accession>
    <name>A0A8J2H7S4_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS2917</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001117">
        <property type="protein sequence ID" value="CAG5079085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H7S4"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035327297" evidence="2">
        <location>
            <begin position="18"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="345"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="391"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5079085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="436" mass="50518" checksum="6E1C8C7C6A0ECB58" modified="2022-05-25" version="1">MRQKIILCCLIVTSVRGDKIDIYDTKIDSTERLKSDAISLNIYMILRELVETCLTNNSNPVMISKELFDYNWNPNKNPLIIIDNVFKKQITSFFPAYPTYVLFFQSIESLKEIINHLKQSALWSIKSPFVIVETESRCKNTRRVLEFLWKKDLLSVYYLCNKKDLTAIFTLNPYASYAPKPWVLIEKFGDSTKNITFYSLQYSKDPELCKSITFEKTDHLKSADIKFTYFSSTDKLLKKQFHDDQLKELINRKVTNLFNIPAYINATPTLEIIKRANSSQLTQGFIQQLVDQTHDVHGSLMPVTETDYKYVDVIADYFHEHEFFILTKKADFFTVINEVSSDVDFVVMTIAVFVMFTIALVLINKEDICGALMDSMRLVVSMGLESPLNRLAMKFIFFCGFLFAFLIVPDFQGHVSAILSNPMRRNFETLEGPLRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H8I3</accession>
    <name>A0A8J2H8I3_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Similar to RANBP9: Ran-binding protein 9 (Homo sapiens)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HICCMSTLAB_LOCUS3832</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RANBP9/10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5083410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H8I3"/>
    <dbReference type="OrthoDB" id="25503at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd12909">
        <property type="entry name" value="SPRY_RanBP9_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.920:FF:000011">
        <property type="entry name" value="RAN binding protein 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013144">
        <property type="entry name" value="CRA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024964">
        <property type="entry name" value="CTLH/CRA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006595">
        <property type="entry name" value="CTLH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006594">
        <property type="entry name" value="LisH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035782">
        <property type="entry name" value="SPRY_RanBP9/10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050618">
        <property type="entry name" value="Ubq-SigPath_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12864">
        <property type="entry name" value="RAN BINDING PROTEIN 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10607">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08513">
        <property type="entry name" value="LisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00757">
        <property type="entry name" value="CRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00668">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00667">
        <property type="entry name" value="LisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50897">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50896">
        <property type="entry name" value="LISH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B30.2/SPRY" evidence="3">
        <location>
            <begin position="23"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="domain" description="CTLH" evidence="4">
        <location>
            <begin position="280"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="336"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="340"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAG5083410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="635" mass="69916" checksum="28FE19593E405D68" modified="2022-05-25" version="1">MMAATSEEQSVMDSSLINCGQQPSDRLKMLYPMVNEEETPLPRSWSPKDKYNYIGLSQNNLRVHYKGFGKTHKDAASVRTTHSIPAACGLYYFEVKIVSKGRDGYMGIGLSAHGVNVNRLPGWDKHSYGYHGDDGHSFCSSGTGQPYGPTFTTGDVIGCGVNLVDNTAFYTKNGTHLGIAFSDLPPNLYPTVGLQTPGEVVDANFGQTPFVFDIGDMINELRVRTRLQIINYPTPDHGQGQWQAVLHKMVSTYLVHHGYCDTAEAFANSTGQPFDEDFSSIKNRQRILKLVLAGRMGEAIKLTTELYPTLLDRDPNLMFALKCRQFVEMVNGSDSEVNQTIGSSTSATNTTTTVNNSNTNTNTNINTNANTNNTYSITNTNTNTNINININTNTSNDNQTSVIQSTKAYNSKSSNGTVEEMNLNNTLNGTADQQFINGQIEDDVDMEMESNTATINNINGFKNTTNGYQNGNPNSNGYKCNGEDIDMEIDSANQNQQNGNSIDNPSVKLSKKQLCGGNKQAIEKMLEFGRQLYSQSIHLRQSYGKNEANKKMLQDAFSLLAYSNPWNSPVGWQLDPQERETVCARLNSAILESTNLPRRPPLEVTISHARELVRLMSGAGLGACGFAVVDNIIQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HA47</accession>
    <name>A0A8J2HA47_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS5424</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5089908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HA47"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5089908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="71" mass="8405" checksum="2E114F6BEDDEBBA9" modified="2022-05-25" version="1">MYILDRETAESLDDTFRLPKSIIHCVQAIDFSVSKCNVKAYRPCCDPDYKCTRLGRRRGKPYIQMLEIIRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HA82</accession>
    <name>A0A8J2HA82_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Similar to tdc-1: Tyrosine decarboxylase (Caenorhabditis elegans)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HICCMSTLAB_LOCUS5496</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the group II decarboxylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5090127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HA82"/>
    <dbReference type="OrthoDB" id="639767at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019752">
        <property type="term" value="P:carboxylic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06450">
        <property type="entry name" value="DOPA_deC_like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1340.10:FF:000001">
        <property type="entry name" value="Histidine decarboxylase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000025">
        <property type="entry name" value="Histidine decarboxylase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000018">
        <property type="entry name" value="Histidine decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1340.10">
        <property type="entry name" value="dopa decarboxylase, N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010977">
        <property type="entry name" value="Aromatic_deC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002129">
        <property type="entry name" value="PyrdxlP-dep_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021115">
        <property type="entry name" value="Pyridoxal-P_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11999">
        <property type="entry name" value="GROUP II PYRIDOXAL-5-PHOSPHATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11999:SF70">
        <property type="entry name" value="MIP05841P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00282">
        <property type="entry name" value="Pyridoxal_deC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00800">
        <property type="entry name" value="YHDCRBOXLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00392">
        <property type="entry name" value="DDC_GAD_HDC_YDC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="582"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="588"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="6">
        <location>
            <position position="307"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR602129-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG5090127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="1170" mass="131603" checksum="0842E926DBE833A5" modified="2022-05-25" version="1" fragment="single">MDINEFRIRGKEMVEYICDFMNNIHTRRVTPDVGPGYLRPLLPSEAPYDGEPWADIMRDVESKIMPGITHWQHPRFHAYFPAGNSFPSILGDMLSDAIGCIGFSWAASPACTELETIVCDWFGKAMHLPNDFLYFSPGSRGGGVIQGSASESVLVCMLAARAQAIARLKESPAHAHLDETALLGKLMAYCSRESHSCVEKDAMICFVKLRILEPDEKSVMRGEILKQAIEADVAEGFVPFFVSTTLGTTACCSFDNLKEIGPVCRQYPGIWLHTDAAYAGNAFICPELRYLMTGIEYADSINTNTNKFLLTNFDCSCLWVRDRFKLTSALVVDPLYLQHTHADTAIDYRHWSIPLSRRFRSLKLWFVLRNYGISGLQNYIRNHCKLAKQFEQLIRKDDRFEVCNEVVLGLVCFRAKGSDKLNQKLLSVINDSGKIHMVPAKVNQKYTIRFALAAPNATSEDVEHAWSVITDYLSEILEGKEIVDKLADIREKKRKATLEQRRSFFVRMVSDPAIQPGFTKTPNRPEAKLETQATIGGLGSNPRTTSSWISWPLAYLMSRESTDTSELSLRFRHLDTMVRLKTGAGSRRGSSNGCSPEPSPTVSPSRGRSPNGRTFKMNIEEFCVRGKEMVEYICEYLRTLEGKRVTANVDPGYLRPLLPNEAPLKPESWNDIMNDVENKIMPGITHWQHPRFHAYFPAGNSFPSILGDMLSDAIGCIGFSWAASPACTELETIVLDWYAKAINLPSGFLAEKKNSKGGGVIQGSASECILVTMLAARNHAINLLKKKEPLIEDSAFLPRLVAYCSTEAHSCVEKAAMICLVKLRVLAPDDRCCLRGSTLEAAIKDDIKHGLVPFFVSTTLGSTGCCSFDNLVEIGPVCKKQPGIWLHVDGAYGGNAFICPELRPLMAGIEYADSFNTNPNKWLLVNFDCSCLWVRDRVKLTSALVVDPLYLQHANSNESIDYRHWGIPLSRRFRALKLWFVMRSYGIIGLQKYIRNHIRLAKKFEAQMRKNKRFEVLNDVRVGLVCFRLKDSDEINQELLANINASGKIHMIPSRMMGKYVIRFCVTKENAIEDDIDYAMEVIDEHASEVLLTHYEGTEIELSAKSPKSPVPLDKKLVRKFSFTRSVTRDVYRRTKSKSTLHDGATPIMVVEDNNSQVDLNDEEVFCSDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HAC5</accession>
    <name>A0A8J2HAC5_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Sulfite oxidase</fullName>
            <ecNumber evidence="4">1.8.3.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HICCMSTLAB_LOCUS5104</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mo-molybdopterin</name>
            <dbReference type="ChEBI" id="CHEBI:71302"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Energy metabolism; sulfur metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Sulfur metabolism.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.8.3.1" evidence="4"/>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5089101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HAC5"/>
    <dbReference type="OrthoDB" id="10051395at2759"/>
    <dbReference type="UniPathway" id="UPA00096"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030151">
        <property type="term" value="F:molybdenum ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043546">
        <property type="term" value="F:molybdopterin cofactor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008482">
        <property type="term" value="F:sulfite oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006790">
        <property type="term" value="P:sulfur compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd02111">
        <property type="entry name" value="eukary_SO_Moco"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.650:FF:000002">
        <property type="entry name" value="sulfite oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.120.10:FF:000007">
        <property type="entry name" value="Sulfite oxidase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.650">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.420.10">
        <property type="entry name" value="Oxidoreductase, molybdopterin-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018506">
        <property type="entry name" value="Cyt_B5_heme-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005066">
        <property type="entry name" value="MoCF_OxRdtse_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008335">
        <property type="entry name" value="Mopterin_OxRdtase_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000572">
        <property type="entry name" value="OxRdtase_Mopterin-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036374">
        <property type="entry name" value="OxRdtase_Mopterin-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19372:SF7">
        <property type="entry name" value="SULFITE OXIDASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19372">
        <property type="entry name" value="SULFITE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03404">
        <property type="entry name" value="Mo-co_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00174">
        <property type="entry name" value="Oxidored_molyb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00363">
        <property type="entry name" value="CYTOCHROMEB5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00407">
        <property type="entry name" value="EUMOPTERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56524">
        <property type="entry name" value="Oxidoreductase molybdopterin-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00191">
        <property type="entry name" value="CYTOCHROME_B5_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0349">Heme</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0500">Molybdenum</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="11">
        <location>
            <begin position="97"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00070338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAG5089101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="537" mass="61211" checksum="0D0697E5F3E72E80" modified="2022-05-25" version="1">MCWRVKIFYNLHKNYLNQKNNKKLLKIINSCYTSHEYTTRGHQNNFTENKSKYLQYSWKAGLISSLIGVSYYLWKNEVYALDLITLKETPGVKKSHLKTYTVEEVGKHDNENDGIWVYYKEGVYDITKFVLKHPGGPEKIMMAAGGSIEPFWMIFANHNVSEIYQLLESMRIGNLDISKDSKKIEATEDPYANDPKRHKVLKVNGPKPFCGETPGPLLCESFLTPADTFYVRNHLPVPEIDIKDYELEIAIEDDTKKVINFENIKKYPKYTITTAIMCNASWSGARLTDVLADLKINEDDWKHVQFEGYDLDPSGVPYGGSIPISRALDPRADIILAYEMNGEPIPRDHGYPIRAIVPGVVGARNVKWLAKIVISNEESRSQFQRGDYKGFSPSVDWDTVDFSKSPAILDMPVTSAICTPTPGEIVKLKDGKIPVKGYAWSGGGKKIIRIDLTVDQGKTWHVAHQLIDDENAKEGRHWSWTLWSAEIPIDVDKNEVEVWVKAVDASYNVQPESFENIWNLRGLLCNAYHRVNVKVKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HAJ5</accession>
    <name>A0A8J2HAJ5_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Similar to Fis1: Mitochondrial fission 1 protein (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HICCMSTLAB_LOCUS5224</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FIS1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5089401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HAJ5"/>
    <dbReference type="OrthoDB" id="421154at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000266">
        <property type="term" value="P:mitochondrial fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043653">
        <property type="term" value="P:mitochondrial fragmentation involved in apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016559">
        <property type="term" value="P:peroxisome fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016543">
        <property type="entry name" value="Fis1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028058">
        <property type="entry name" value="Fis1_TPR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13247:SF0">
        <property type="entry name" value="MITOCHONDRIAL FISSION 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13247">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 11 TPR REPEAT PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14852">
        <property type="entry name" value="Fis1_TPR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAG5089401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="93" mass="11020" checksum="3EBD52857359822E" modified="2022-05-25" version="1">MENILNEVVSSEDLKKFEKIYNEQLTTSQVTQKAQFEYAWCLVRSRYPADVRKGIVLLEDLGSTWNGSSWWSNCWTSKYSWSWYRNGKEILAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HAR4</accession>
    <name>A0A8J2HAR4_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Similar to Zinc finger protein Xfin (Xenopus laevis)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">HICCMSTLAB_LOCUS5317</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="1">May be involved in transcriptional regulation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5089650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HAR4"/>
    <dbReference type="OrthoDB" id="6077919at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000065">
        <property type="entry name" value="B-cell CLL/lymphoma 6, member B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000446">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000771">
        <property type="entry name" value="zinc finger protein 648"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000624">
        <property type="entry name" value="zinc finger protein 697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050758">
        <property type="entry name" value="Znf_C2H2-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23234:SF10">
        <property type="entry name" value="RIKEN CDNA 6720489N17 GENE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23234">
        <property type="entry name" value="ZNF44 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="16"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="14"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="148"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="176"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="204"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="232"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="260"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="427"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="455"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="483"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="797"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="825"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="855"/>
            <end position="882"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="883"/>
            <end position="910"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="911"/>
            <end position="938"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="972"/>
            <end position="999"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="65"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="342"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="997"/>
            <end position="1035"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="87"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="115"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="394"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1014"/>
            <end position="1025"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CAG5089650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="1035" mass="119609" checksum="AF1361DB483EB1FE" modified="2022-05-25" version="1">MEVNDVLCEERIFKIEIEEFQIDENDCQGSYLCQSVDFMKKEELGNNSIITEEITVVPAEFIKEEPEDTDDENSNISISTEEPDAVKTNTTLPETSTAKRTRSERSPKSSPKTSNTKKKTKKLNPKSINSESKKVARSTLQIEPAKVYTCEVCSAQFHRKGNFNQHKLVHTGEKPFGCKLCSSRFNQNSSLKRHVLTHSEEKPYACHMCSWKFRLKQQLQSHLSTHMEEKPYTCDICSRKFRQKVSLKRHLSIHFDEKPFSCDVCLRSFRERGQIKIHKRIHSGEQPYACEICPAKFHEFKIDENDCQGSYLRQSIYFVKEEEPENNSIITEEITVVPEFIKEEPEDTDDENSNISISIEESDTEKTTTTLPGTSISKRTRSKQSPKSSPKISNTKKKTKKLNPKSINSESKKFAKSTLQIEPAEVYTCEVCSAKFHRRGNFNKHKVVHTGEKPFGCKLCPLKFNQNSSLKRHMHTHSEEKPYACNMCPWKFRLNHQLQSHLSTHMEDKLEKMNMEVLPFETVVIKVEKNDEEWRINEVLENPLDIGKLEDEPEGNSVTLKDTIDVPDVEFNDSELKGNRDYPIDIEEIKIEETEDPIYPNITDVSKKTIRKNAVKDLQEIPTEEAPKNESMWKTFKCDKCAIEFVNESSLATHAKKYKFNCDVCPKCFISRQGLCAETLPFENIVVKVEKCEDEESCDEHKDPLHDFPIDTEEVKVEISEDSELLGDIADAPSLIKIEAEEAKECAIKTEPPSSPINAMEMLADLRKVAGKKHLVKRKWKRPRSQRIKKDWYPKNWICDVCSAKFAFKSGLARHVVLHTDDRPFACTICPRTFRYLDNLNRHLRIHATGEQKRYICNVCSLECASGRGLASHKRSHLKPKPFMCKICKSRYHADIGLKLHMRVHTHKFPFTCVTCLATFDKRLHLVNHMKTHIGEKISGKKTFNCEICSWTCHRKFQMTKHMEMHAFENLFTCDVCSAKFRHKTSLTNHMAFHKNEKSKLVNSRGSRGRRKKTSLDESLSEKKNLKMQKTVVEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HBG8</accession>
    <name>A0A8J2HBG8_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Similar to THAP8: THAP domain-containing protein 8 (Homo sapiens)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HICCMSTLAB_LOCUS6291</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5092659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HBG8"/>
    <dbReference type="OrthoDB" id="7685656at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.210.20">
        <property type="entry name" value="THAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026521">
        <property type="entry name" value="THAP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006612">
        <property type="entry name" value="THAP_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038441">
        <property type="entry name" value="THAP_Znf_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47696:SF2">
        <property type="entry name" value="PROVISIONAL ORTHOLOG OF THAP DOMAIN CONTAINING 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47696">
        <property type="entry name" value="THAP DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05485">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00692">
        <property type="entry name" value="DM3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00980">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50950">
        <property type="entry name" value="ZF_THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="THAP-type" evidence="6">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAG5092659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="205" mass="24032" checksum="9D6D49EA916CFCCE" modified="2022-05-25" version="1">MRKCVYCNIKNVKGGELSFVRFPTDEKILQLWIQNMNYESNWKPLKNHYLCSQHFSSECFDFRDKLYRLRKGSIPTNFDRSKENVVLVSNYRQILDDEKHVCDPLTKRLNVTSSILNSEESYNCIAETMSKVNTETVPMRVIDHDHSYGETQEKLKKDLMLAMAKIDQLTAKNRTLLKKDKRNKQRIASMIQVINQLSKKNVSCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HBQ9</accession>
    <name>A0A8J2HBQ9_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS6693</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5093252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HBQ9"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5093252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="121" mass="12896" checksum="50D4B272CEC98BD9" modified="2022-05-25" version="1">MRTLPNIGVRGSGPSPKYPMTFLVLMSSAEVGGLGSMMMGCSTSLRSSTPPVSSGLISLDPSSDLSLFSLRNSSTLISGVVSSFNESSSLRQRGGSLFNDWRIFFAVSELVRFISAYSWGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HBS2</accession>
    <name>A0A8J2HBS2_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">protein-tyrosine-phosphatase</fullName>
            <ecNumber evidence="4">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HICCMSTLAB_LOCUS5161</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell junction</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="4"/>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5089243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HBS2"/>
    <dbReference type="OrthoDB" id="5854685at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070161">
        <property type="term" value="C:anchoring junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009887">
        <property type="term" value="P:animal organ morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048666">
        <property type="term" value="P:neuron development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd14473">
        <property type="entry name" value="FERM_B-lobe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13189">
        <property type="entry name" value="FERM_C_PTPN4_PTPN3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17100">
        <property type="entry name" value="FERM_F1_PTPN3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000002">
        <property type="entry name" value="Band 4.1-like protein 5 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000039">
        <property type="entry name" value="Tyrosine-protein phosphatase non-receptor type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.80.10:FF:000003">
        <property type="entry name" value="Tyrosine-protein phosphatase non-receptor type 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019749">
        <property type="entry name" value="Band_41_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014847">
        <property type="entry name" value="FA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014352">
        <property type="entry name" value="FERM/acyl-CoA-bd_prot_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035963">
        <property type="entry name" value="FERM_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019748">
        <property type="entry name" value="FERM_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019747">
        <property type="entry name" value="FERM_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000299">
        <property type="entry name" value="FERM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018979">
        <property type="entry name" value="FERM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018980">
        <property type="entry name" value="FERM_PH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000242">
        <property type="entry name" value="PTP_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041783">
        <property type="entry name" value="PTPN3/4_FERM_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45706">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45706:SF4">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08736">
        <property type="entry name" value="FA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09380">
        <property type="entry name" value="FERM_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00373">
        <property type="entry name" value="FERM_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09379">
        <property type="entry name" value="FERM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00102">
        <property type="entry name" value="Y_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00935">
        <property type="entry name" value="BAND41"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00700">
        <property type="entry name" value="PRTYPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00295">
        <property type="entry name" value="B41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01195">
        <property type="entry name" value="FA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01196">
        <property type="entry name" value="FERM_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00194">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47031">
        <property type="entry name" value="Second domain of FERM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00660">
        <property type="entry name" value="FERM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00661">
        <property type="entry name" value="FERM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50057">
        <property type="entry name" value="FERM_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50055">
        <property type="entry name" value="TYR_PHOSPHATASE_PTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0965">Cell junction</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FERM" evidence="12">
        <location>
            <begin position="33"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="10">
        <location>
            <begin position="578"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="11">
        <location>
            <begin position="671"/>
            <end position="752"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAG5089243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="775" mass="87540" checksum="E4F41C270D6D5253" modified="2022-05-25" version="1">MIESVSRRALSGSSGSYHVRGAELARDRRLKSLAATVVFLDETQHTFQLDKRAKGQILLDLVFQHLELIEKDYFGLQYAENPTVYPNSDAMRWLDPSKQVKKQIRSKGGQFFFKVKFYVSDPSKLQEEYTRYQFYLQIRRDILHGKLQLPTSTACLIASYTVQSELGDYHPEEHGPGYLSKLQLIPGQTEEMEKKICELHKLHKGQLPADAEFNFLDHAKRLDMYGVELHKARDSTNKEIQLGVTSIGLVVFQNNIKINVFSWSKIVKISFKRKQFFIQLRREQSENYDTLLGFNMQTYRSSKNLWKACVEHHTFFRLHSPKMRPRRFPLTLSSRFTYSGRTEFQTVEDGKHRARVERTFIRSPSKRIVHGVNQVPIEEKGKVVSAPARPPRPYDNKVQSLGSREPRQAWVEGNNSDDEGGFLSLREEINTSTHTQGGAFSPVLGSRILSYVDDDTAERNIYDLPDYSEPTSSPAPQILDDGLVTIRLTPDEQGRFGFNVKGGLDLDIPILSRDTGNGELTLTVRPNALYNALAGTDEASEEEPPYRYVPDAPHSAVGSDALAQSMLLLADGLASGALIAQYEQLYRKNPELTSLESKKAENQNKNRYRDISPYDVTRVILMGCVNGDYINANYVNMEIPGSGIINRYIATQGPLSSTVADFWQMVLEAGSTLVVMLTTLVERGQRVRAARTGMVEPAVVHCSAGIGRTGVLVLMETALCLIEANQPVYPLDIVRSMRDQRAMMIQNASQYKFVCEAVHKAYTEGIAKPLIEFSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HC96</accession>
    <name>A0A8J2HC96_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS6854</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5093464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HC96"/>
    <dbReference type="OrthoDB" id="9995573at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5093464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="379" mass="43845" checksum="E4765490D08F92C6" modified="2022-05-25" version="1">MNVSIFTKSLSEAAADFVSKLYSLPDLSRTNVQELLNAFTIFLQTEPFNMLLNEMIQKCVFLGDSSQSIQVYKGMFIPLRNVLKEIFKLPFIFNDSREYLQNLEENDVLIKNVVQSESWKKKKATLGEKLVFPIFMYQDDYETNNPLGSHKGLGKMGAVYIVMPCLPPHLSSKTENIFLLTLYKSNDLKYPNQIKTRFIKMSASESRCILENIGVLIGDWVPRKNLHWRLVILIKEIFDIVSATVIHKGISYYLTNLIGEYLHLLSILFPGSLKPKHHYMLHYATIMERKGPLWNMNCMRPESKNRDSKITSRITLNRTNISKTLAIKSQLILNHRLRNRLVSNKLYESNKSTLKSVPELQEYCSYAKLLSFSHGEKFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HD17</accession>
    <name>A0A8J2HD17_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Similar to Anp32a: Acidic leucine-rich nuclear phosphoprotein 32 family member A (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HICCMSTLAB_LOCUS5614</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the ANP32 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5090391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HD17"/>
    <dbReference type="OrthoDB" id="2160613at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000131">
        <property type="entry name" value="acidic leucine-rich nuclear phosphoprotein 32-related protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045081">
        <property type="entry name" value="AN32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11375">
        <property type="entry name" value="ACIDIC LEUCINE-RICH NUCLEAR PHOSPHOPROTEIN 32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11375:SF0">
        <property type="entry name" value="ACIDIC LEUCINE-RICH NUCLEAR PHOSPHOPROTEIN 32 FAMILY MEMBER A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14580">
        <property type="entry name" value="LRR_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG5090391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="153" mass="17358" checksum="274CFDFEC1C7F2DA" modified="2022-05-25" version="1">MEKRIELEKRGRNPAEITEFVLDNCRSTNIVGLTDEFVALKSLSLINVGLTSLKGFPVLPNLRKLELSDNRISGGLNFLLSSPKLTHLNLSGNKIKDLETLQPLKEFQNLKNLDLFNNEATEMDNYREKVFGLIPSLRYLDGIITSPRKEKKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HDC3</accession>
    <name>A0A8J2HDC3_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">[histone H3]-trimethyl-L-lysine(4) demethylase</fullName>
            <ecNumber evidence="4">1.14.11.67</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">HICCMSTLAB_LOCUS7375</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>N(6),N(6),N(6)-trimethyl-L-lysyl(4)-[histone H3] + 3 2-oxoglutarate + 3 O2 = L-lysyl(4)-[histone H3] + 3 formaldehyde + 3 succinate + 3 CO2</text>
            <dbReference type="Rhea" id="RHEA:60208"/>
            <dbReference type="Rhea" id="RHEA-COMP:15537"/>
            <dbReference type="Rhea" id="RHEA-COMP:15547"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:16842"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:61961"/>
            <dbReference type="EC" id="1.14.11.67"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the JARID1 histone demethylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="24">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.11.67" evidence="4"/>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5094049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1678912at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034647">
        <property type="term" value="F:histone H3K4me/H3K4me2/H3K4me3 demethylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16864">
        <property type="entry name" value="ARID_JARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15605">
        <property type="entry name" value="PHD1_Lid_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15606">
        <property type="entry name" value="PHD2_KDM5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15610">
        <property type="entry name" value="PHD3_KDM5A_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000023">
        <property type="entry name" value="Lysine (K)-specific demethylase 5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.650:FF:000028">
        <property type="entry name" value="Lysine-specific demethylase lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.60:FF:000001">
        <property type="entry name" value="Putative lysine-specific demethylase 5b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.60">
        <property type="entry name" value="ARID DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.650">
        <property type="entry name" value="Cupin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001606">
        <property type="entry name" value="ARID_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036431">
        <property type="entry name" value="ARID_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003347">
        <property type="entry name" value="JmjC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003349">
        <property type="entry name" value="JmjN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048615">
        <property type="entry name" value="KDM5_C-hel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047970">
        <property type="entry name" value="KDM5A_PHD2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013637">
        <property type="entry name" value="Lys_sp_deMease-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004198">
        <property type="entry name" value="Znf_C5HC2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10694">
        <property type="entry name" value="LYSINE-SPECIFIC DEMETHYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10694:SF33">
        <property type="entry name" value="LYSINE-SPECIFIC DEMETHYLASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01388">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02373">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02375">
        <property type="entry name" value="JmjN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21323">
        <property type="entry name" value="KDM5_C-hel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08429">
        <property type="entry name" value="PLU-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02928">
        <property type="entry name" value="zf-C5HC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01014">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00501">
        <property type="entry name" value="BRIGHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00558">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00545">
        <property type="entry name" value="JmjN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46774">
        <property type="entry name" value="ARID-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51011">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51184">
        <property type="entry name" value="JMJC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51183">
        <property type="entry name" value="JMJN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="18" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="10" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="12" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="14" id="KW-0804">Transcription</keyword>
    <keyword evidence="13" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 17" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="JmjN" evidence="22">
        <location>
            <begin position="43"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="ARID" evidence="21">
        <location>
            <begin position="108"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="20">
        <location>
            <begin position="329"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="domain" description="JmjC" evidence="23">
        <location>
            <begin position="472"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="20">
        <location>
            <begin position="1181"/>
            <end position="1236"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="20">
        <location>
            <begin position="1569"/>
            <end position="1624"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1455"/>
            <end position="1574"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="18">
        <location>
            <begin position="972"/>
            <end position="999"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS51183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS51184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="CAG5094049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="1667" mass="189522" checksum="D3C0DB3C559C9B29" modified="2022-05-25" version="1">MVIPYLPVRRHIERSSHKIKGNIIRKGKFTNTNKILFGAPPEAPVFEPTAEEFLDPLGYIAKIRPIAEKAGICKIKPPPNWQPPFAVDVDKFKFVPRIQRLNELEAKTRIKLNFLDQIAKFWELQGSSLKIPLVEKKALDLYSLHKIVSEEGGIETVRRERRWAKIANKLGYPSGKSVGSILKNHYERILYPFDVFKQGKTLGDIKIEAPEIEASEKKDRDYKPHGIISRQQIKPPAAKFSRRSKRFTGQDEKQDVATIKQEDCKEECDSDNECKEEIKMEDDKDSKELKKLQFYGAGPKMAGYNTKETKKSNKTRGIKYTYDYDPLAKYICHNCGRGDMEESMLLCDGCDDSYHTFCLLPPLTEIPKGDWRCPKCVAEEVSKPMEAFGFEQAQREYTLQQFGEMADQFKSDYFNMPVHMVPTSLVEKEFWRIVSSIDEDVTVEYGADLHTMDHGSGFPTKTSVNLFTCDQEYAESAWNLNNLPVLHGSVLGHINADISGMKVPWMYVGMCFATFCWHNEDHWSYSINYLHWGEPKTWYGVPGSEAEKFEHSMKSAAPELFHSQPDLLHQLVTIMNPTILTNEGVPVFRTDQHAGEFVVTFPRAYHAGFNQGYNFAEAVNFAPADWLKIGRECITHYSNLRRFCVFSHDELVCKMSLDPDSLDIGVATATYQDMLTMVDDEKKLRKNLLEWGVTEAEREAFELLPDDERQCEACKTTCFLSAVTCSCQTNQLVCLRHFRNLCDCLPEKHTLRYRYTLDELPIMLQKLKLKAESFDSWVIKVKEAMDPKGEKIELSEFKDLLSEAENKKFPDSELLTALTTAVQDAEKCASVAQQLLNNKQRTRTRQTVDTKYKLTIEELTLFYKEITNLCCELKESDGVKYILDQVLQFQKDAEEFEAQSDDCDLDKLEKCIDFGDSICIELPQLVRLKQKLHQIQWLDEVKTMLDESKSITREELVKLIDQGRTISPHITVENMLSKLQQLVVNIDKWEEKAKGYLQAKNGQNISVIEEFIQEADEIDAYLPSLDNLQDILNKAKNWTKTVEEIQARREIFPYYDTLDELVRKGKNIPLHLEQLSVLESTLSQAKAWKERTARTFLRKNSHYTLMEALSPRIGVGVQAMKTKKNKGDESAGALYVCDTKLDDSSDSANVVAAFKLAEQREMDAMRSLRERNMQKGNTDDSRFCVCRRSRFGLMLQCELCKDWFHSNCVPLPKTIHKGKVQSSREIKFLCPCCLRSRRPRLESILALLVGLQKIPIRLPEGEALTCLTERAMNWQDRARRALATEEISSVLTKLSALSQKLVEAAAREKTEKIITSELKKAANNPELHQRVQAIAPLSGVHSDDSVLSAADDDDDVVTLDGDEPSCSTFNSNEHAYSFISKLHRKLQSQGGESPVTLSISARTRLEDLMMEGDLLEVALDETQDIWRILSHTNSPTTVRKYATFEEVQASFNSDMKDAKKRGRKRKSDEFDMGKTISRQKIVDEKSPANTPNAIIKKKGANTPTGGSGAGAGAGAAAAATGLNNKDKKIMPQSPLKRGPRKIKRKEGEDVPKKKGGNRKKTKQDTSDEEDDCAADSCLRPNGREVDWVQCDGGCNGWFHMHCVGLDKTELAEEDDYICSNCKDADQNTTIYCYNALDALVYLYQSQGYLSGDNEPDIEEPTSFARTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HDZ8</accession>
    <name>A0A8J2HDZ8_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similar to pol: RNA-directed DNA polymerase from mobile element jockey (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS7557</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5095134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HDZ8"/>
    <dbReference type="OrthoDB" id="7989680at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5095134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="380" mass="44283" checksum="001FDF78F53AF6E4" modified="2022-05-25" version="1">MKPMVKLITSVITRKVNGLGNLPRRKDNKKINVGSWIYRSGYFTCGTVNSPTLFSIYFSTLLSSFDLNKGDLKAIAFADDLVVYLPGKSPLKIQDGFQKLLNVIDEFMQTWNLRINYTKCETIVFRRSTHFLTKGSRPGLNTFTLKGTNPASAAFKANRSLFYCKHLTSRAKIICHQLLIRPIITYASPIWWNTSASFMEKIRVLNRKCIRTCLRVYRSRESNFKKQISNETLYNIANIPRIDNFIIKLTRDYFAKLSSIENKEIEKILETPDQQIYITNHNSACLPPQAFIYFDKKGIIQDSNNVPTIYHWGRNVANKRINLTTDMIANNKYDPVYSMALPERDKMDFYSLDERYWWLEDSCHRIKLKLRKLNGWSATW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HE90</accession>
    <name>A0A8J2HE90_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Sedoheptulokinase</fullName>
            <ecNumber evidence="10">2.7.1.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Carbohydrate kinase-like protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">HICCMSTLAB_LOCUS5832</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Acts as a modulator of macrophage activation through control of glucose metabolism.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>sedoheptulose + ATP = D-sedoheptulose 7-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23844"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16802"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57483"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.14"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FGGY kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.14" evidence="10"/>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5090988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HE90"/>
    <dbReference type="OrthoDB" id="10264182at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050277">
        <property type="term" value="F:sedoheptulokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901135">
        <property type="term" value="P:carbohydrate derivative metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071396">
        <property type="term" value="P:cellular response to lipid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901701">
        <property type="term" value="P:cellular response to oxygen-containing compound"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006091">
        <property type="term" value="P:generation of precursor metabolites and energy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006071">
        <property type="term" value="P:glycerol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046496">
        <property type="term" value="P:nicotinamide nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006163">
        <property type="term" value="P:purine nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009617">
        <property type="term" value="P:response to bacterium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd07777">
        <property type="entry name" value="ASKHA_NBD_FGGY_SHK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000111">
        <property type="entry name" value="Sedoheptulokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000132">
        <property type="entry name" value="Sedoheptulokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018484">
        <property type="entry name" value="FGGY_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10196:SF67">
        <property type="entry name" value="SEDOHEPTULOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10196">
        <property type="entry name" value="SUGAR KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00370">
        <property type="entry name" value="FGGY_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carbohydrate kinase FGGY N-terminal" evidence="13">
        <location>
            <begin position="8"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00052736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00057196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00066341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00069425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00076706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CAG5090988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="465" mass="50498" checksum="ED183D6A7C617019" modified="2022-05-25" version="1">MPNGGKLVLGIDLGTTSVKVIILSTETKQIIAKQSKEPQANVPSDLGIEGNKQDVPKILSAVHNCVSRLPKDLLRQVKSIGICGQMHGVALWKTTGSPEKEDGTFKLEIDRQSVSHLYTWQDARCDKNFLSTLPQSKSHLPVHTGFGCATLFWFARNKPEKLQKYDRCGTVQDLLVNLLTGSDEITMSTQNAASWGYFLTDQAKWETELMANAGFPVNLLPKSILKPGQVAGKLRHPWFGIPAGVPIGVALGDLQCSVLALLKEPDEAVLNISTSAQLTYVHPSFDPNDCPESGSIEYFPYFNDKYLAVAASMNGGNTLATFVKTLQHWAMDLGFSVPQSKVWEKLIALGQEESAVSTMEIEPLLLGERYDPDKTASVTGITLNSLSLGSVFRSLCSGVIRNLHNMMSQDLLKAKGIKRIVGNGSGLVRNPVLQKEVTNWYKLSLELGQSGDAAFGAALAALASN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HEL3</accession>
    <name>A0A8J2HEL3_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS6579</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5093092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HEL3"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5093092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="128" mass="14329" checksum="8A4CB87107589955" modified="2022-05-25" version="1">MRCGKLDTFSRDCPCPYRKRHKVRHALPKPARDPTGSTTPRNEQCPEKSRAEGGHFQPTALKPDDKRPFVEIRLGNGNPLEPNREQPDRDQPDRENPEPVVDETLGPRRVTRAMAKKAKLASAAGEPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HFP6</accession>
    <name>A0A8J2HFP6_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Similar to Adpgk: ADP-dependent glucokinase (Mus musculus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HICCMSTLAB_LOCUS8935</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5097903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HFP6"/>
    <dbReference type="OrthoDB" id="5847021at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043843">
        <property type="term" value="F:ADP-specific glucokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007666">
        <property type="entry name" value="ADP_PFK/GK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21208">
        <property type="entry name" value="ADP-DEPENDENT GLUCOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21208:SF1">
        <property type="entry name" value="ADP-DEPENDENT GLUCOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04587">
        <property type="entry name" value="ADP_PFK_GK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="Ribokinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51255">
        <property type="entry name" value="ADPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG5097903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="403" mass="45574" checksum="5C5C1257E174B4B5" modified="2022-05-25" version="1">MGSSKITFGTLISVIIIVIAIYYRNSDLELRSRLTHVLNGLEHLESKHEIAVKPKIAVGYGACADVYIDAKYLLKYSEKVGDPQHYDEIDSKEQLLKSFAYYFRHGAAAERYMRNEQLFDKLVAKARTFDSSYSSIGGNAPVMAMRFAKEGCDVLLAAKMTDSLRLMVPDEIEIVGGKVDRDDIHLILEYKRGEQWGPYTSARANRYIIHNDNNNPTVSSLEAFDEALKEFKPDLLVVSGLQMMDNFPFAEGVKKERLNKIRQQMMSQLPSTRIHFEMASFVEKDLITDLENMVLPYADSLGMNEQEVANLYNSMYHGNISLVADSSPRVATILDYMRVLFKLVRMRGKEIQGARELTRIHVHTLAYQAILTVKSSKWKNTMAAAAKASLVAHRHVCGTSNKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HFR5</accession>
    <name>A0A8J2HFR5_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Similar to nAChRalpha1: Acetylcholine receptor subunit alpha-like 1 (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HICCMSTLAB_LOCUS9326</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5099984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HFR5"/>
    <dbReference type="OrthoDB" id="410315at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005230">
        <property type="term" value="F:extracellular ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18997">
        <property type="entry name" value="LGIC_ECD_nAChR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.170.10:FF:000028">
        <property type="entry name" value="AcetylCholine Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.390">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006202">
        <property type="entry name" value="Neur_chan_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036719">
        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038050">
        <property type="entry name" value="Neuro_actylchol_rec"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006029">
        <property type="entry name" value="Neurotrans-gated_channel_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18945">
        <property type="entry name" value="NEUROTRANSMITTER GATED ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02931">
        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02932">
        <property type="entry name" value="Neur_chan_memb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00252">
        <property type="entry name" value="NRIONCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90112">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane pore"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="250"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="279"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="319"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel ligand-binding" evidence="6">
        <location>
            <begin position="42"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel transmembrane" evidence="7">
        <location>
            <begin position="256"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG5099984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="449" mass="51209" checksum="B6024FD7AABD609B" modified="2022-05-25" version="1">MCRFTINFYRAFVSYFLLIYVNYNITPVHSAYAELWNATWVDRLKRDLLSKYDKFARPAQHFNATRVFFGMTINHISVEEFKSAISVQAWVRMVWTDDKLKWNASNYGGLGRLQAGSHEVWQPDIILYNSIAISSVEHYGDTHCHIYSDGTVIWVPPTHFLALCDLDLRLWPFDTQICQLKLGSWSYSGNQIDLRLNNNSLEGTINLVDNTEWRLVDVTRLRNVTTYECCKDEPYIHLVFTLTIKRNAPLYSSVFLTPAAAIVIMCLVNFWLPAQSKEKLLLCGVNVIVISLFLIYFGYRIPPHSTNSPLLVSFYSGCLYQVTISLVISAIVINLSRRPYSRPLPRHLKKILVGWPGRYLGLSDLIQAIQSEYSAGEQELRESQGVDSSSVYASNLISTCSENGDRENIISSPVNVTQLEWILLATAIDRSSFLVFCNIFILMAISCLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HGI1</accession>
    <name>A0A8J2HGI1_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">HICCMSTLAB_LOCUS9360</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">P-body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the DEAD box helicase family. DDX6/DHH1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5100052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HGI1"/>
    <dbReference type="OrthoDB" id="10265785at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017148">
        <property type="term" value="P:negative regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033962">
        <property type="term" value="P:P-body assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd17940">
        <property type="entry name" value="DEADc_DDX6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000114">
        <property type="entry name" value="ATP-dependent RNA helicase DDX6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000364">
        <property type="entry name" value="ATP-dependent RNA helicase DDX6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47960">
        <property type="entry name" value="DEAD-BOX ATP-DEPENDENT RNA HELICASE 50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 12 16" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="15">
        <location>
            <begin position="55"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="13">
        <location>
            <begin position="86"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="14">
        <location>
            <begin position="266"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="11">
        <location>
            <begin position="55"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CAG5100052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="444" mass="50687" checksum="2B9926845DCC0716" modified="2022-05-25" version="1">MMTETHINSNHMLNSSLGSKSDLEKMDDVGWKSKLRIPPRDKRIKTSDVTNTRGNEFEEFCLKRELLMGIFEKGWEKPSPIQEASIPIALSGKDILARAKNGTGKTGAYSIPVLEQVDPRKDIIQALVIVPTRELALQTSQICIELAKHMDVKVMVTTGGTNLRDDIMRIYQKVHVIIATPGRILDLMDKNVANMDHCRILVLDEADKLLSQDFKGMLDHVISRLPSERQILLYSATFPLTVKQFMEKHLRDPYEINLMEELTLKGVTQYYAFVQERQKVHCLNTLFSKLQINQSIIFCNSTQRVELLAKKITDLGYCCYYIHAKMAQAHRNRVFHDFRAGLCRNLVSSDLFTRGIDVQAVNVVINFDFPKMAETYLHRIGRSGRFGHLGIAINLITYEDRFNLHRIEQELGTEIKPIPKVIDPSLYVARPEDNTSLDEGNVSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HGJ2</accession>
    <name>A0A8J2HGJ2_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Jumonji domain-containing protein 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HICCMSTLAB_LOCUS7480</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>L-lysyl-[protein] + 2-oxoglutarate + O2 = 4-hydroxy-L-lysyl-[protein] + succinate + CO2</text>
            <dbReference type="Rhea" id="RHEA:57156"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:15084"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:141495"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the JMJD6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5094980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HGJ2"/>
    <dbReference type="OrthoDB" id="203487at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016706">
        <property type="term" value="F:2-oxoglutarate-dependent dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045905">
        <property type="term" value="P:positive regulation of translational termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.650">
        <property type="entry name" value="Cupin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041667">
        <property type="entry name" value="Cupin_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003347">
        <property type="entry name" value="JmjC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050910">
        <property type="entry name" value="JMJD6_ArgDemeth/LysHydrox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12480:SF6">
        <property type="entry name" value="2-OXOGLUTARATE AND IRON-DEPENDENT OXYGENASE JMJD4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12480">
        <property type="entry name" value="ARGININE DEMETHYLASE AND LYSYL-HYDROXYLASE JMJD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13621">
        <property type="entry name" value="Cupin_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00558">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51184">
        <property type="entry name" value="JMJC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="JmjC" evidence="4">
        <location>
            <begin position="131"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00047762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00082904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAG5094980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="401" mass="47315" checksum="420906CB5A8FD856" modified="2022-05-25" version="1">MELLEINEFVKNNNNDLNISCNTRINDAITYNDFFTQYLIKNEPCVFKSGITNQWPCVNNWVFNNAPNFKHLKKLYGSCQVPVANCKIKYYNAQLKDEMTIEKFMDYWQEYRNKNYTTDMPVLYLKDWHCLRDNPGDLFYKVPKYFASDWLNEYYLAHPQFSDDYMFVYMGPKGSWTPLHVDVFTSFSWSANIVGKKRWLLFPPGEENNLRDTHGHLLYDIDSPEQDNFWSGSNKALEIIQGPGEIVFVPSGWHHQVWNLEDTISINHNWINGCNILNVWKELKKALLAVMKEIADCYNMDNWKSQCQTILKASHGMDYLQFYDFLSFIIKKRINSINNNKPCTNSDTREFGVNHILFDLKRAKFVLSYLIVDSKDNDIYDIVFRDNRPENLIECIDAILI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HGW6</accession>
    <name>A0A8J2HGW6_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similar to Rrnad1: Protein RRNAD1 (Rattus norvegicus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS7325</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5093999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HGW6"/>
    <dbReference type="OrthoDB" id="5875367at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025714">
        <property type="entry name" value="Methyltranfer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052220">
        <property type="entry name" value="METTL25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12496">
        <property type="entry name" value="CGI-41 METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12496:SF2">
        <property type="entry name" value="METHYLTRANSFERASE-LIKE PROTEIN 25B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13679">
        <property type="entry name" value="Methyltransf_32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransferase" evidence="1">
        <location>
            <begin position="165"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5093999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="503" mass="58443" checksum="F5F8FB9B6CCCD30C" modified="2022-05-25" version="1">MGVKYEDYTHVYSRHVWYFAKVTIMCTCKVCLGVRRVVDNIFEIFKIHGWILDAYIIDFYQDDLWSKLPSSWRNFFKTISIQELGSWMLDELQSKKVWPLSLIALKQSIKLLTIDRNPISDAETKFVCSGAQWNYRKLENSDFKIPKNDLACRHKNLFTKHIKIKKRYEIDKFSEICAKCCYLANCKCIVDTGAGMGHLARQLSYKYNLSVICVEQTKELSDLAKKYDAEYLVTIKKHLPDFDSRSSYHLCAKLCQEDSSNESLIGNINEIFESTFGRKSIEEGFGFIGLHPCGDLAVTLLKLYVKQPNVKFITIVGCCYMKLTTSGERNSLGYPLSNYLRSKSNNYLSYAALEVACHAVENYCDKMKTGDYNNLKVHAYRGMLEMLLIKKAGLIMRHGRVNSVKVNEHMTFQRYCELATAKFDDDKKILESDYNWEEVRKHLDRWQEVVAFEALRMMLAPLVETAVLLDRFLFLSEHHLKPLLKAEFDPRRSPRNFVLVSIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HH72</accession>
    <name>A0A8J2HH72_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Olfactory receptor 8</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HICCMSTLAB_LOCUS10003</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5100930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HH72"/>
    <dbReference type="OrthoDB" id="6617147at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005549">
        <property type="term" value="F:odorant binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004984">
        <property type="term" value="F:olfactory receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004117">
        <property type="entry name" value="7tm6_olfct_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21137">
        <property type="entry name" value="ODORANT RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21137:SF35">
        <property type="entry name" value="ODORANT RECEPTOR 19A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02949">
        <property type="entry name" value="7tm_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0552">Olfaction</keyword>
    <keyword evidence="8 11" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="9" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="44"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="74"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="136"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="192"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="276"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="307"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAG5100930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="401" mass="45972" checksum="5CD49ED70E05AA5D" modified="2022-05-25" version="1" fragment="single">MIIKNSELLEDINYNLKLTKWILKPLGVWSFVTRDSNLTSKLSSVLIIFVNSFIMFITVMPCGIHMIFRETDQVVKIILMGPFGFYLTNCCKYYFIMYRSNIIKNCLNHLKADWARVKTEEDRQKMIKSVNVGRNITKLCAIFMFSGGVSYHTVMPIWKGSTLNELNETIRPLAYPGNEIFFNCQKTPIYEFIFFLHFICGLVLLTITTGACHLAAIFATHACGQVDILKSQLENLLKKENPKTNDTIDNRIASIIQSHVRILDFSKSIEIMLREVCLVEVGASTMIICLLEYYCMIEWSNSETINILTYLMLLTALTFNIFIFCYIGEILNQQCSSIGESTYMINWYKMPGNKGKYLMLTIASSRNQRQLTAGGMLDLSLHSFGNIIKTSLVYLNMLRTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HHE0</accession>
    <name>A0A8J2HHE0_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS8290</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5096599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HHE0"/>
    <dbReference type="OrthoDB" id="7701102at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5096599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="143" mass="16461" checksum="F90CA803D09657B7" modified="2022-05-25" version="1">MKLKEDFSAWCLESAALKDEAKPWFESVQLARRPLVSINRLRSGHTSLKASLSKLNIVSSSRCPCDMDEETPDHIFWICPRFVSQRKKLRKALQKVSKSYPDNVETLLNRIDNVANTTDGTRCLRRSETFGKTPQPRSRPFSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HHG2</accession>
    <name>A0A8J2HHG2_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">tryptophan--tRNA ligase</fullName>
            <ecNumber evidence="3">6.1.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Tryptophanyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HICCMSTLAB_LOCUS9648</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.2" evidence="3"/>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5100575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HHG2"/>
    <dbReference type="OrthoDB" id="15808at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004830">
        <property type="term" value="F:tryptophan-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070183">
        <property type="term" value="P:mitochondrial tryptophanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.240.10:FF:000002">
        <property type="entry name" value="Tryptophan--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.240.10">
        <property type="entry name" value="Tyrosyl-Transfer RNA Synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002305">
        <property type="entry name" value="aa-tRNA-synth_Ic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002306">
        <property type="entry name" value="Trp-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050203">
        <property type="entry name" value="Trp-tRNA_synthetase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00233">
        <property type="entry name" value="trpS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43766">
        <property type="entry name" value="TRYPTOPHAN--TRNA LIGASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43766:SF1">
        <property type="entry name" value="TRYPTOPHAN--TRNA LIGASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00579">
        <property type="entry name" value="tRNA-synt_1b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01039">
        <property type="entry name" value="TRNASYNTHTRP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAG5100575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="271" mass="30402" checksum="EC7D3402E3F64A72" modified="2022-05-25" version="1">MTATLLACGIDPQKSIIFQQSTVSRHTELAWTLGCMLTMKKLALLPQFKEKSETLKNIPVGLYIYPVLQSADILLYKATDVPVGKDQLQHLHLAQHLVHFFNGKYGDTFPVPNPLINESSGSVKSLKDPSKKMSKSNNEKKSLIRLIDEPEIIKKTIKKAVTDFTSEITYEPSSRPGVSNLVMIHSRMLEKSPEVICKEAQGLNTVQYKSLVTDVIIEKLTPIRQEYMRLMSAPDYVNSVLKNGSLRALPLADQCWLEVREKVGFSGGMLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HHW1</accession>
    <name>A0A8J2HHW1_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="2">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HICCMSTLAB_LOCUS9770</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="2"/>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5100697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HHW1"/>
    <dbReference type="OrthoDB" id="8062037at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039525">
        <property type="entry name" value="RNF126-like_zinc-ribbon"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14369">
        <property type="entry name" value="Zn_ribbon_19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="E3 ubiquitin-protein ligase RNF126-like zinc-ribbon" evidence="8">
        <location>
            <begin position="12"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF14369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAG5100697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="80" mass="9209" checksum="8B2B83DAB25C9FC6" modified="2022-05-25" version="1">MAEAVVDGTSMSRFFCHKCSIEIERLLPDYTCPNCASGFIERLENAEDHDANMEMNSEDFNDIDFDVKLSDWSSEPNNFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HHX3</accession>
    <name>A0A8J2HHX3_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">GCS light chain</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Gamma-ECS regulatory subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Gamma-glutamylcysteine synthetase regulatory subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Glutamate--cysteine ligase modifier subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HICCMSTLAB_LOCUS9201</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="pathway">
        <text evidence="1">Sulfur metabolism; glutathione biosynthesis; glutathione from L-cysteine and L-glutamate: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Heterodimer of a catalytic heavy chain and a regulatory light chain.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the aldo/keto reductase family. Glutamate--cysteine ligase light chain subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5099721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HHX3"/>
    <dbReference type="OrthoDB" id="5596051at2759"/>
    <dbReference type="UniPathway" id="UPA00142">
        <property type="reaction ID" value="UER00209"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017109">
        <property type="term" value="C:glutamate-cysteine ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030234">
        <property type="term" value="F:enzyme regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035226">
        <property type="term" value="F:glutamate-cysteine ligase catalytic subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006750">
        <property type="term" value="P:glutathione biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032963">
        <property type="entry name" value="Gclm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13295">
        <property type="entry name" value="GLUTAMATE CYSTEINE LIGASE REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13295:SF4">
        <property type="entry name" value="GLUTAMATE--CYSTEINE LIGASE REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0317">Glutathione biosynthesis</keyword>
    <keyword evidence="9" id="KW-0436">Ligase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00030406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00031154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00031732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAG5099721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="210" mass="23363" checksum="B41B698DB0C64011" modified="2022-05-25" version="1">MVSNSVLYNTGNILSLNELKLKAGKTSEEELVEALKIVLKDSQNTSGNDINAGGGDREELKITELHINSIGTLILAYGEAQNSGKELESLQKLWPVLEKYIQNGTLTSVGLSNVDTGVFIKLYQWAKIRPTIVQINLAMCCVVPPVLQEFTQQNQIQLLTHNDPYHILNKDSCVELFGDEAKLNWVAKYQVHIKCRGVLSSKGYFVNITK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HHY0</accession>
    <name>A0A8J2HHY0_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ZSWIM1/3 RNaseH-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS5750</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5090795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HHY0"/>
    <dbReference type="OrthoDB" id="123417at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052579">
        <property type="entry name" value="Zinc_finger_SWIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048324">
        <property type="entry name" value="ZSWIM1-3_RNaseH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31569">
        <property type="entry name" value="SWIM-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31569:SF4">
        <property type="entry name" value="SWIM-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21056">
        <property type="entry name" value="ZSWIM1-3_RNaseH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ZSWIM1/3 RNaseH-like" evidence="1">
        <location>
            <begin position="76"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF21056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5090795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="422" mass="48626" checksum="F7BCB10C241089CE" modified="2022-05-25" version="1">MARNLKLVHAFPENRRLPPELRQKVEEYLNLGCSNKKIRYELSSKYNILATSKDISNIRQSLRPEKSNDLPTFVNLLKTKYGCSTKIKVTDDGNFQALFFTNTAMQNSMKNWPEMLFIDGTYKLFNLGFTLYLIMIQTGSGRGEIVGAAILASETSDVMKWVAETFKEFNREASAQTKTIMTDKDLTERSAFAESSFVNDYADLLAKTAFDKFNEELNKYDSVTITKYCNETRACYLDVDGYPIMSSITECRCHFRKSFKLPCVHILVTRKFFNENQFCSELCDSKWLKATSINKFNQEFHEILLADTIFNNQSTNTTMTTDDSIIATDIIEEDGLKITCEEERKQILQKYFEKIMGNSLKVPEEEFKLVQNQLEKIASNDKQNGHNNTDEKIVILPEKKILRGRPKSARKTTTGFFPRKNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HI80</accession>
    <name>A0A8J2HI80_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Angiotensin-converting enzyme</fullName>
            <ecNumber evidence="10">3.4.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HICCMSTLAB_LOCUS8793</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="10">Binds 2 Zn(2+) ions per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9 10">Belongs to the peptidase M2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.-.-" evidence="10"/>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5097619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HI80"/>
    <dbReference type="OrthoDB" id="10029630at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004180">
        <property type="term" value="F:carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008241">
        <property type="term" value="F:peptidyl-dipeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06461">
        <property type="entry name" value="M2_ACE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1370.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001548">
        <property type="entry name" value="Peptidase_M2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10514">
        <property type="entry name" value="ANGIOTENSIN-CONVERTING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10514:SF45">
        <property type="entry name" value="ANGIOTENSIN-CONVERTING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01401">
        <property type="entry name" value="Peptidase_M2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00791">
        <property type="entry name" value="PEPDIPTASEA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52011">
        <property type="entry name" value="PEPTIDASE_M2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="3 7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 5 10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="10" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 11" id="KW-0732">Signal</keyword>
    <keyword evidence="6 10" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035312830" description="Angiotensin-converting enzyme" evidence="11">
        <location>
            <begin position="20"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="307"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="307"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="5">
        <location>
            <position position="60"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="138"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="432"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR601548-10"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR601548-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR601548-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR601548-8"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAG5097619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="549" mass="64450" checksum="B398DC4EE3C0AD90" modified="2022-05-25" version="1">MIRFILFCVSVLFLENCHARYLEGLNLNLGEALQFLREYDQEASGVCNKVMTAQWNFATNVTDLEEQTTKLKFERSSWRKAVNFAWTRVPDPLARRQLKMITMKGRNALTQDKFNEVIIPIHHLIVEMKELHSRARLCPYKKTGITCDMDMTAEVSKIMAQSRDYEELLHYWRAWHEAVGPPLKNKYMRYVQLANQAARLNGFTDAGDQMREAFEDDYFQQNIAEVISAINPLYKNLFTYVRTRLIDRYGDKLRPDGPLPAHLLGNMWAQNWEGIYDLVEPFAGARRFDYKDQPYIFRNEALPGFHEAVSDAIELSVMNPRHFQRIGLYNNSTEDYESNINFLMLMALRKVVYLPFAYIIDQWRWRVFSDGVADMTTRWWELRLQYQGIVPPLPRLERDFDPGAKYHIPADIPYTKYFVGAVLQFQLFESLCDISGHVGELHLCDIYRSQEAGRLLSEILSQGSSRNWHEVVRLMTRGKMDRIDVGPMLRYFEPLFKWLQRQNEIEPIIGWITSQDDTSLFAHWYRSSSEKVKAWSLSILIPLIICLVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HII4</accession>
    <name>A0A8J2HII4_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS8401</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5096819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HII4"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5096819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="59" mass="7034" checksum="CF14428BFAC39C8D" modified="2022-05-25" version="1">MEILLASKVVVMALYTMKVSKDVMYQKMYQDVRIGTKQMKKRLKLIYTNYSLLDDIFHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HIJ3</accession>
    <name>A0A8J2HIJ3_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS8310</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5096639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HIJ3"/>
    <dbReference type="OrthoDB" id="7615806at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5096639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="116" mass="13866" checksum="A34F1F42941497FC" modified="2022-05-25" version="1">MVVLTRQKWFLKPFAVDMRRTWKASKTVSSLSRIIANTIRPQIKKRRVLLEAVYSEARAKINKKTLHEWQDHWTSEETGRWTARLIPNINVWLSREQEDTDFFLTQLLTGHRQFNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HIU5</accession>
    <name>A0A8J2HIU5_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase</fullName>
            <ecNumber evidence="15">3.2.1.114</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">HICCMSTLAB_LOCUS9814</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>N(4)-{beta-D-GlcNAc-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + 2 H2O = 2 alpha-D-mannopyranose + an N(4)-{beta-D-GlcNAc-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc}-L-asparaginyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:56052"/>
            <dbReference type="Rhea" id="RHEA-COMP:14368"/>
            <dbReference type="Rhea" id="RHEA-COMP:14369"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28729"/>
            <dbReference type="ChEBI" id="CHEBI:60615"/>
            <dbReference type="ChEBI" id="CHEBI:60625"/>
            <dbReference type="EC" id="3.2.1.114"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Golgi apparatus membrane</location>
            <topology evidence="2">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the glycosyl hydrolase 38 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.114" evidence="15"/>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5100741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HIU5"/>
    <dbReference type="OrthoDB" id="10261055at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004572">
        <property type="term" value="F:mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006013">
        <property type="term" value="P:mannose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006491">
        <property type="term" value="P:N-glycan processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.110.10:FF:000016">
        <property type="entry name" value="Alpha-mannosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1180:FF:000019">
        <property type="entry name" value="Alpha-mannosidase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.110.10">
        <property type="entry name" value="Glycoside hydrolase 38, N terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.50">
        <property type="entry name" value="Glycoside hydrolase family 38, central domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.30">
        <property type="entry name" value="Golgi alpha-mannosidase II, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015341">
        <property type="entry name" value="Glyco_hydro_38_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037094">
        <property type="entry name" value="Glyco_hydro_38_cen_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000602">
        <property type="entry name" value="Glyco_hydro_38_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027291">
        <property type="entry name" value="Glyco_hydro_38_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028995">
        <property type="entry name" value="Glyco_hydro_57/38_cen_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050843">
        <property type="entry name" value="Glycosyl_Hydrlase_38"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11607">
        <property type="entry name" value="ALPHA-MANNOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11607:SF3">
        <property type="entry name" value="LYSOSOMAL ALPHA-MANNOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09261">
        <property type="entry name" value="Alpha-mann_mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01074">
        <property type="entry name" value="Glyco_hydro_38N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00872">
        <property type="entry name" value="Alpha-mann_mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88688">
        <property type="entry name" value="Families 57/38 glycoside transferase middle domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="14" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="11" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Glycoside hydrolase family 38 central" evidence="17">
        <location>
            <begin position="235"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00066412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00093232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM00872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="CAG5100741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="589" mass="67585" checksum="032E4F844A1A8295" modified="2022-05-25" version="1">MGQLTQLTVGHQWLGTNLGYKPTSSWAIDPFGLSPTMPYLYKKSGLQNALIQRVHYAVKKRLAQDKNLEFRWRQLWDTIGLSEILTHMIPFPGYGIQYSCGPDPYICYQFDFRRVWSWNPFARKYIPEEITTENLVERATTLLDQYRKKAQLYRSNVLLVPLGDDFRYTTSDEWDSQYNNYQRLFDYMNENKLFHVDVKFGTLTEYFNLLRNDLDIDQLPSLSGDFFTYADKDEDYWSGYYTSRPFHKRLDRVLIDALHGAEVISSIAWASGFHYLHHDGITGTARDNVVKDYAEKMIAALTNLAHVTQQSAVHLLRTGEDLILEPESVYLTLDQIRSHHTSIDDKQVLSFSDNDNFKRVVIYNSLPRKRERVQTLFVSTPFVKVTDSYGEPIQSQISPIWTESATFSDEHYELSFVVTVAGFGLNTYLIHSVKSDDKLSSRVNIANITLLNAKNQPYSVPGFENIQIVSSPQEFSIRQRPEISAHFSKSGLLKSLQTGDTTASVDMEFVTYETDSGGTYLFIPNKPDPDPIYTTDDHIIHLVTGPILSRVFIQLPQVKQTYTLFNSLGSDGLGLHVSNLFDITETNNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HJ60</accession>
    <name>A0A8J2HJ60_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similar to PLCXD1: PI-PLC X domain-containing protein 1 (Homo sapiens)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS8930</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5097893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HJ60"/>
    <dbReference type="OrthoDB" id="2015280at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051057">
        <property type="entry name" value="PI-PLC_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000909">
        <property type="entry name" value="PLipase_C_PInositol-sp_X_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13593">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13593:SF103">
        <property type="entry name" value="RE10370P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00388">
        <property type="entry name" value="PI-PLC-X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00148">
        <property type="entry name" value="PLCXc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosphatidylinositol-specific phospholipase C X" evidence="1">
        <location>
            <begin position="74"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5097893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="352" mass="40529" checksum="5BF5485915B4F371" modified="2022-05-25" version="1">MPIYYHEPEYKSSVVKTGIPPTHASYDVSSSFVEQCTGYYGAWIRNDTIQKLKCLSTYPDWMSKQKEHLRYMTIGNIFIPGTHNSGSYSEGIPQTLTERYSVTQDATILDQLISGAHFLDLRPCKYQYDYWICHGSYYMQPFEAVIRDIKEFMDNTDEIVILSFKEFPNAELNDHIAPIPFGLQRKMTLGEMWDSGKRLIISYDYSVRSKSSMRSGYRFWDPIVQEWGNVNSPEKLKEFIDKHESYSKNAAKLWDDDPLIFRAMMAAVTLDMTSIVTDSVAHFFGQGSYSLREIGTQVGPLVTEWYNENYCSSANIVTVDFIDATGIVPVAIYWNKIRGERNYAKKINSSNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HK22</accession>
    <name>A0A8J2HK22_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Geranylgeranyl transferase type-1 subunit beta</fullName>
            <ecNumber evidence="4">2.5.1.59</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Geranylgeranyl transferase type I subunit beta</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">Type I protein geranyl-geranyltransferase subunit beta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">HICCMSTLAB_LOCUS9583</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>geranylgeranyl diphosphate + L-cysteinyl-[protein] = S-geranylgeranyl-L-cysteinyl-[protein] + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21240"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11537"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57533"/>
            <dbReference type="ChEBI" id="CHEBI:86021"/>
            <dbReference type="EC" id="2.5.1.59"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="14">Heterodimer of FNTA and PGGT1B. PGGT1B mediates interaction with substrate peptides.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the protein prenyltransferase subunit beta family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.59" evidence="4"/>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5100496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HK22"/>
    <dbReference type="OrthoDB" id="24893at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005953">
        <property type="term" value="C:CAAX-protein geranylgeranyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004662">
        <property type="term" value="F:CAAX-protein geranylgeranyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02895">
        <property type="entry name" value="GGTase-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.20:FF:000005">
        <property type="entry name" value="Geranylgeranyl transferase type-1 subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041960">
        <property type="entry name" value="GGTase_I_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045089">
        <property type="entry name" value="PGGT1B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001330">
        <property type="entry name" value="Prenyltrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008930">
        <property type="entry name" value="Terpenoid_cyclase/PrenylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11774">
        <property type="entry name" value="GERANYLGERANYL TRANSFERASE TYPE BETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11774:SF4">
        <property type="entry name" value="GERANYLGERANYL TRANSFERASE TYPE-1 SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00432">
        <property type="entry name" value="Prenyltrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48239">
        <property type="entry name" value="Terpenoid cyclases/Protein prenyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0637">Prenyltransferase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <keyword evidence="7 17" id="KW-0808">Transferase</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Prenyltransferase alpha-alpha toroid" evidence="16">
        <location>
            <begin position="9"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00031713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00050428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00065714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00078363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CAG5100496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="342" mass="38384" checksum="200F31136978FFF5" modified="2022-05-25" version="1">MARNFSAQLEKKKHAQYFKRILQVMPSQMAQYDSNRVMFAFFAVSGLDILDSLDVLNESEKLSAIEWIYRLQVTDAGIRSGFQASIMLPDDTPHYQCGYLPMTYTALATLLTLGDDLKRVNKKSILEGMRACQNPNGCFMAMITESESDMRFLYCACCVSAILNDWSGMNKTTAIDYIVKSISYDGAMGQGPGLESHGGSTFCAVASLYLMNELHNVLSEEQINKLRRWCLMRQNSGFQGRPGKPSDTCYSFWVGATLHMLDAGHFIDPDENRKFILSTQDASIGGFAKFYDTRADPMHTYLGLCGLSLMGEPGLLPMNAALNVSNRVYKHLKEIHKKWKTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HK58</accession>
    <name>A0A8J2HK58_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">HICCMSTLAB_LOCUS9419</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the DEAD box helicase family. DDX27/DRS1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5100170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HK58"/>
    <dbReference type="OrthoDB" id="10259843at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd17947">
        <property type="entry name" value="DEADc_DDX27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000842">
        <property type="entry name" value="ATP-dependent RNA helicase DRS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050079">
        <property type="entry name" value="DEAD_box_RNA_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959:SF1">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE RHLE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 12 17" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="16">
        <location>
            <begin position="161"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="14">
        <location>
            <begin position="192"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="15">
        <location>
            <begin position="401"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="14"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="95"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="604"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="662"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="11">
        <location>
            <begin position="161"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="14"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="32"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="102"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="604"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="637"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="662"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="712"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="734"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="752"/>
            <end position="770"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00043999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CAG5100170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="770" mass="86901" checksum="228E190DEC18B21B" modified="2022-05-25" version="1">MVKEKYDLIKSISDDQEVEDFSDNSEFGDDDVQPHREKVVDEKKKDFDTEFQFISDAAEYNKDTWNDLSKYIKRKPKSKLDDKIKRVRREQNIEEKPIKVDDDSDVEADNDNDNHTNGDIYLSDDELKKDTFRTKEHKGKKKNEKADIMDFEETATADNSATFYQMNLSRPLLKAITTMNYVQPTPIQAATIPVALMGRDICGCAATGTGKTAAYMLPTLERLLYKPADGPAITRVVVLVPTRELGVQVYQVTKQLCQFTNVEAGLAVGGLDIKAQEAALRKNPDIIIASPGRLIDHIQNTPNFTLNSIEVLIIDEADRMFNEDFETQLGCIVKECSRSRQTMLFSATMTEKVKDLAAVSLNRPVKVFVDSNIDVAFNLRQEFIRIRAGREKDREAILAALVCRTFRDHTIIFVQTKKQAHRLHILLGLLGIQVGELHGNITQPQRLENLRKFKDAEVDVLVATDVAARGLDISGIKTVINFVMPATLEHYIHRVGRTARAGRVGVSVSLAGEEERTLVKKIIKNAKNPVKNRIIAPDIVEKYNKKLESLEPDVEKILEMQRTEKEIAKIENQANRVEKLLKEEDDGPKRNWFQTTKERKLEKDKLKLTEKVNKQKEKKEGPSNLVANNKPKKKKAKEPELDPAEARAMKELEKVAAFQARLAKKSGKLKKIRTVHDGHSENAPNKQGAKKRSRSSFTTDLTDTSKKGVKRLRYEANKVQRESFGKVRGKSAGGKKPMPGKKPMPGKKPMGGKKPAFNKKSPGKGPKSKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HK97</accession>
    <name>A0A8J2HK97_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Similar to Ergic2: Endoplasmic reticulum-Golgi intermediate compartment protein 2 (Mus musculus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HICCMSTLAB_LOCUS10125</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum-Golgi intermediate compartment membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ERGIC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5101052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HK97"/>
    <dbReference type="OrthoDB" id="5541786at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030134">
        <property type="term" value="C:COPII-coated ER to Golgi transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033116">
        <property type="term" value="C:endoplasmic reticulum-Golgi intermediate compartment membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045888">
        <property type="entry name" value="Erv"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012936">
        <property type="entry name" value="Erv_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039542">
        <property type="entry name" value="Erv_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10984">
        <property type="entry name" value="ENDOPLASMIC RETICULUM-GOLGI INTERMEDIATE COMPARTMENT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10984:SF30">
        <property type="entry name" value="ENDOPLASMIC RETICULUM-GOLGI INTERMEDIATE COMPARTMENT PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07970">
        <property type="entry name" value="COPIIcoated_ERV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13850">
        <property type="entry name" value="ERGIC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="31"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="domain" description="Endoplasmic reticulum vesicle transporter N-terminal" evidence="8">
        <location>
            <begin position="13"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="domain" description="Endoplasmic reticulum vesicle transporter C-terminal" evidence="7">
        <location>
            <begin position="165"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAG5101052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="391" mass="44787" checksum="9A7B7D67415D1F55" modified="2022-05-25" version="1">MILRRRNVNLKTVKELDAFPKVPDSYKNKSAVGGTFSFVTFVVISWLVISETRYFLNARLHFKFEPDIDVDDKLKINIDMTVAMPCSLIGADILDSTNQNLLGFEPLNEEETWWELSPDQRSHFDALKHMNSYLREEYHAIHELLWRSNQVAFMGEMPKRTVIPDHRPDACRLYGNINLNKVAGNFHITAGKSLSLPRGHIHIFAFMTSRDYNFTHRINKFSFGEESPGIVQPLDGDEKIASDNMMLYQYFIEVVPTDIYTLMKTTKTYQYSVKDYSRPINHAQGSHGVPGIFFKYDTSALRVKVTQNRDSLIQFLVKLCATVGGIYVTSGLINSAIQACWYIVSCKFFRKEVEEDRRTSNGKAMTNKKLTTLDLINVATPDIIDVTLNPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HKC1</accession>
    <name>A0A8J2HKC1_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Similar to MTMR14: Myotubularin-related protein 14 (Homo sapiens)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HICCMSTLAB_LOCUS9811</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5100738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HKC1"/>
    <dbReference type="OrthoDB" id="2408718at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004438">
        <property type="term" value="F:phosphatidylinositol-3-phosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13213">
        <property type="entry name" value="PH-GRAM_MTMR14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039802">
        <property type="entry name" value="MTMR14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039803">
        <property type="entry name" value="MTMR14_PH-GRAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010569">
        <property type="entry name" value="Myotubularin-like_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13524">
        <property type="entry name" value="MYOTUBULARIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13524:SF2">
        <property type="entry name" value="MYOTUBULARIN-RELATED PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06602">
        <property type="entry name" value="Myotub-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myotubularin phosphatase" evidence="3">
        <location>
            <begin position="298"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="429"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="429"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF06602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG5100738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="631" mass="71081" checksum="5FCC5A2A572DA7F4" modified="2022-05-25" version="1">MTDIAIQDLQDLLVYFSKNTYKAKDADCTGQTIMQQCLLLVDLDYTHSVINNVAGDLSAHYPSHLIIFENEKRRNPYICDTPPQLPRTTETIYENTYDSNKLKDLIKNARFARCRSRFPLPVIFYKGRFICRSATLSGGPEIYGRSGLNYLFAGNESANAFHQRLDEAGCSDSALSDWQLFDKVRNQDIKLLKALNVGNIIDFMVEKKKVKFGMNVTSSEKVDKEKRYADFTIISLPYPGCEFFKEFRENDYQAKGLIFDWSQTHVDAQIGVPEDIISTQLKINWEQYQVWDLVKLTQNYFKLILNYLSDSSNGMLIHCISGWDRTPLFISLLRISLWADGAIHTSLNAHQILYFTIAYDWLLFGHDLQDRLNEEFSITHKSTRVRHSVQCHDSDPQLDNAMFDTESVVTLSSVSSNMSLNSWCSSFSQNSRDSQDNNPPTVFPCSSTDNQDDSHSNGNVMPWTFFNSQNKESDKKTVGHGSCSPLLSNSRTSPVAVPIPGRFRQRNESSSSAGSWQMISGTGSLRGSTTSNCALPEFLSASTLTCKSQCITCSGQTSQESSVTVIEDDSALSSAQSRKDRLHSVRTLFYNIYSHTVGFRMKENSESSGFGQLLGNFAEKVGILSVQRTSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HKU0</accession>
    <name>A0A8J2HKU0_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS9492</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5100315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HKU0"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035175392" evidence="1">
        <location>
            <begin position="22"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5100315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="182" mass="20484" checksum="919EEB08C630AFC2" modified="2022-05-25" version="1">MFGDKFSIIFIFFGLFCNIVGRNAEASRKIVNVDEKNFGNFDVLNVKVNKQDGKTESKKIVIVNIDNLNLTVDSTRGGVWIYLKNVTSPESKKKINILINDIVVVLDTRNYVTLSIKSTKSINNNNNNNNNQIIMNGNDLIINFNNGNVFVSSNDINDIDINFHWDSAAFSTTIGENLEIIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HLE7</accession>
    <name>A0A8J2HLE7_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">3'(2'),5'-bisphosphate nucleotidase 1</fullName>
            <ecNumber evidence="15">3.1.3.57</ecNumber>
            <ecNumber evidence="3">3.1.3.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">3'-phosphoadenosine 5'-phosphate phosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Bisphosphate 3'-nucleotidase 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">Inositol-polyphosphate 1-phosphatase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">HICCMSTLAB_LOCUS12677</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>1D-myo-inositol 1,3,4-trisphosphate + H2O = 1D-myo-inositol 3,4-bisphosphate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:70319"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58414"/>
            <dbReference type="ChEBI" id="CHEBI:83241"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:70320"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>1D-myo-inositol 1,4-bisphosphate + H2O = 1D-myo-inositol 4-phosphate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:15553"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58282"/>
            <dbReference type="ChEBI" id="CHEBI:58469"/>
            <dbReference type="EC" id="3.1.3.57"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:15554"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>3'-phosphoadenylyl sulfate + H2O = adenosine 5'-phosphosulfate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:77639"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58243"/>
            <dbReference type="ChEBI" id="CHEBI:58339"/>
            <dbReference type="EC" id="3.1.3.7"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:77640"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>adenosine 2',5'-bisphosphate + H2O = AMP + phosphate</text>
            <dbReference type="Rhea" id="RHEA:77643"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:194156"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="3.1.3.7"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:77644"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>adenosine 3',5'-bisphosphate + H2O = AMP + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10040"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58343"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="3.1.3.7"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:10041"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 18">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the inositol monophosphatase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.57" evidence="15"/>
    <dbReference type="EC" id="3.1.3.7" evidence="3"/>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5107294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HLE7"/>
    <dbReference type="OrthoDB" id="411145at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008441">
        <property type="term" value="F:3'(2'),5'-bisphosphate nucleotidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004441">
        <property type="term" value="F:inositol-1,4-bisphosphate 1-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01640">
        <property type="entry name" value="IPPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.190.80:FF:000006">
        <property type="entry name" value="Bisphosphate nucleotidase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.540.10:FF:000023">
        <property type="entry name" value="Protein CBR-TAG-231"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.540.10">
        <property type="entry name" value="Fructose-1,6-Bisphosphatase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050725">
        <property type="entry name" value="CysQ/Inositol_MonoPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020583">
        <property type="entry name" value="Inositol_monoP_metal-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000760">
        <property type="entry name" value="Inositol_monophosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020550">
        <property type="entry name" value="Inositol_monophosphatase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43028">
        <property type="entry name" value="3'(2'),5'-BISPHOSPHATE NUCLEOTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43028:SF5">
        <property type="entry name" value="3'(2'),5'-BISPHOSPHATE NUCLEOTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00459">
        <property type="entry name" value="Inositol_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56655">
        <property type="entry name" value="Carbohydrate phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00629">
        <property type="entry name" value="IMP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00630">
        <property type="entry name" value="IMP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0452">Lithium</keyword>
    <keyword evidence="7 18" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 18" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="18">
        <location>
            <position position="73"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="116"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="118"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="244"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00040342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00041815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00044466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00044478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00044479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00044484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00044519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00044544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00044554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR600760-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="CAG5107294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="305" mass="32992" checksum="C706D0690AB64CD3" modified="2022-05-25" version="1">MAQCHPLVTRLVASSVTAATQAGKIIREIFTQGDLNIIDKGVNDLQTEADRSAQSCIIESLSRQFPDITIIGEEGTSQCQVPPEWIVNDLDPDVMKVKLPDYLENVSPKDVCVWVDPLDGTSEFTQGLVDHVTVLVGVAVGKKTIGGVIHQPYYKDVQKSSLGRTLWGIDKVGIGGFKPIPPPSGKRIITTTRSHSNKTVQAALDAMEPDEIIRVGGAGHKVMLLLEGKANAYVFASSGCKRWDTCAPEAVLNAAGGTLTDLNGEHYPYNAETEHPNTKGVLATAPGEQHSWYLSRIPDQVKQEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HMJ7</accession>
    <name>A0A8J2HMJ7_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">limulus clotting factor C</fullName>
            <ecNumber evidence="9">3.4.21.84</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HICCMSTLAB_LOCUS12021</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>Selective cleavage of 103-Arg-|-Ser-104 and 124-Ile-|-Ile-125 bonds in Limulus clotting factor B to form activated factor B. Cleavage of -Pro-Arg-|-Xaa- bonds in synthetic substrates.</text>
            <dbReference type="EC" id="3.4.21.84"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.84" evidence="9"/>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5104476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HMJ7"/>
    <dbReference type="OrthoDB" id="10002959at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042381">
        <property type="term" value="P:hemolymph coagulation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000120">
        <property type="entry name" value="Putative serine protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050127">
        <property type="entry name" value="Serine_Proteases_S1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033116">
        <property type="entry name" value="TRYPSIN_SER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24264:SF20">
        <property type="entry name" value="TRYPSIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24264">
        <property type="entry name" value="TRYPSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00135">
        <property type="entry name" value="TRYPSIN_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0353">Hemolymph clotting</keyword>
    <keyword evidence="4 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 10" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0720">Serine protease</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0768">Sushi</keyword>
    <keyword evidence="11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="289"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="12">
        <location>
            <begin position="45"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00052079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00066707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAG5104476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="309" mass="35448" checksum="655DA0B37AD20872" modified="2022-05-25" version="1">MFIQLSNIYSIFIIINLFSRIEYLIAKKDNYSSNNKNELTISNRIVGGYAVKISKLPFMVSMQWRHDSEHFCGGSYIRPTFVLTAAHCLCLRTPRGTWTVMNPWLFVVVGGSANLKFAPTWQVQNIYRFIPHQGFHFRTMINDIGLIQLVKPFHITNYVRFIKLPRARIDLRENHLCSTMGWGDTKMINAPKILREVWLPLMANEECEKYLGGELPMQQMCAGKKEGGVDACQGDSGGPLICDNIQVGIVSWGYGCAERHSPGVYTRVDRYLPWIYRAILRNYSSTTFYNHYLLLIIVIIIIISSSTFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HN27</accession>
    <name>A0A8J2HN27_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Leucine-rich repeat protein soc-2 homolog</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Protein soc-2 homolog</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6 7">protein Sur-8 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HICCMSTLAB_LOCUS12384</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Acts as a Ras effector and participates in MAPK pathway activation. Probably acts as a regulatory subunit of protein phosphatase that specifically dephosphorylates Raf kinase and stimulate Raf activity at specialized signaling complexes upon Ras activation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SHOC2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5106687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HN27"/>
    <dbReference type="OrthoDB" id="676979at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000031">
        <property type="entry name" value="leucine-rich repeat protein SHOC-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000115">
        <property type="entry name" value="leucine-rich repeat protein SHOC-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000281">
        <property type="entry name" value="Leucine-rich repeat protein soc-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000450">
        <property type="entry name" value="Leucine-rich repeat protein soc-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050216">
        <property type="entry name" value="LRR_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055414">
        <property type="entry name" value="LRR_R13L4/SHOC2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051:SF54">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23598">
        <property type="entry name" value="LRR_14"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00364">
        <property type="entry name" value="LRR_BAC"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="16"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Disease resistance R13L4/SHOC-2-like LRR" evidence="10">
        <location>
            <begin position="237"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="domain" description="Disease resistance R13L4/SHOC-2-like LRR" evidence="10">
        <location>
            <begin position="472"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="70"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="88"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF23598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAG5106687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="610" mass="68039" checksum="DA8BF20072493BE7" modified="2022-05-25" version="1">MKKSNKYRTGVGNISSVCLSEAKSDRAEPQDSLGNFYMKEQDIPEYLEGCGLTTCSAGNDMPEAVEDLPKEHHKEKKLSTASIASGGDTKKTVTVKHPESNKPKPTAKKCKPIQADLDVAKEFIRCRDECLTRLDLSKSSITNLPSSVRDLSHLQEFYLYGNKLVTLPPEIGCLTSLRILALNENSLTSLPDTLENLKSLKVLDLRHNKLSEIPEVVYKLTSLTTLFLRFNRVRYVSDNIRNLTNLTMLSLRENKIKSLPAGIGKLVNLITFDVSHNHLEHLPEEIGNCVQLSTLDLQHNELLDIPETIGNLVAVTRLGLRYNRLSSIPKSLANCRLMDEFSVEGNQVSHLPDGLLSSLSELITITLSRNCFSAYPSGGPSQFTNVDSLNMEHNQIDKIPYGIFSRAKNLTKLNMKENQLTSLPLDIGTWVNMVELNLGTNQLTKIPDDIQCLQNLEILTLSNNLLKRIPASIGNLRKLRVLDLEENKIECLPNEIGFLRDLQKLILQSNQVTSLPRAIGHLLNLTYLSVGENNLNYLPEEIGTLENLDSLYVNDNANLHNLPFELALCTNLSIMSIENCPLSKIPAEIVAGGPSFVIQFLKMQGPYRSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HNE5</accession>
    <name>A0A8J2HNE5_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RNA helicase</fullName>
            <ecNumber evidence="3">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">HICCMSTLAB_LOCUS11552</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="3"/>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5103523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HNE5"/>
    <dbReference type="OrthoDB" id="10265785at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000849">
        <property type="entry name" value="ATP-dependent RNA helicase DBP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000318">
        <property type="entry name" value="ATP-dependent RNA helicase DDX19B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 17" id="KW-0347">Helicase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="16">
        <location>
            <begin position="89"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="14">
        <location>
            <begin position="122"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="15">
        <location>
            <begin position="304"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="28"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="12">
        <location>
            <begin position="89"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="30"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CAG5103523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="478" mass="53488" checksum="23784AC981A49FE9" modified="2022-05-25" version="1">MASGKVDWGAVTKEQDLLQVNVKNLSLSSETKELESKDKDKDKDDGADGPMSPAEKSLLQKIIHKGLVESTKDLEIQRKDPSSPLYSVKSFELLHLKPELLKGVYAMGFNAPSKIQETALPTLLADPPQNMIAQSQSGTGKTAAFVLAMLSRVNVDKNYPQVLCLSPTYELAIQTGEVAAKMSQFCPEIKIKYAVRGEEVPRGSKISDHIIIGTPGKVLDWALKYRFFDLSKISVFVLDEADVMIATQGHQDQCIRIHKMLPKSSCQMMFFSATYEPEVMEFAEIIVSNPLIIRLMREEESLDNIKQYYVKCRSVEEKYVAITNIYSVISIGQAIIFCHTRRTAGWLAEKMTKDGHRVAILSGDLTVEQRIAVLDRFRAGLEKVLITTNVLARGIDVAQVTIVVNFDLPMDQNRKADCETYLHRIGRTGRFGKSGIAINLVDSEESALICQEIERHFNKKIHYLDAEDPDEIEKIGTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HR75</accession>
    <name>A0A8J2HR75_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS13095</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5108153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HR75"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5108153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="94" mass="10920" checksum="85A65825450735EB" modified="2022-05-25" version="1">MTLELASRMFNDQLIVSGKPETPSEDLVHTVTRLDSVRIDKKRRSTGSRDIMVECKSPQLVSNFIAEKRKHKNFTANILDSEMDRIYKEEYIDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HRD8</accession>
    <name>A0A8J2HRD8_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="18">Kainate 2 (Mus musculus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">HICCMSTLAB_LOCUS12986</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="15">Postsynaptic cell membrane</location>
            <topology evidence="15">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5107935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HRD8"/>
    <dbReference type="OrthoDB" id="5984008at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045211">
        <property type="term" value="C:postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015276">
        <property type="term" value="F:ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.190.10:FF:000167">
        <property type="entry name" value="Eye-enriched kainate receptor, isoform B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000067">
        <property type="entry name" value="glutamate receptor 2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.190.10:FF:000060">
        <property type="entry name" value="Glutamate receptor ionotropic, kainate 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000134">
        <property type="entry name" value="Glutamate receptor, ionotropic kainate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019594">
        <property type="entry name" value="Glu/Gly-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015683">
        <property type="entry name" value="Ionotropic_Glu_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001320">
        <property type="entry name" value="Iontro_rcpt_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18966">
        <property type="entry name" value="IONOTROPIC GLUTAMATE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00060">
        <property type="entry name" value="Lig_chan"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10613">
        <property type="entry name" value="Lig_chan-Glu_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00079">
        <property type="entry name" value="PBPe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="14" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="13" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="9 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0628">Postsynaptic cell membrane</keyword>
    <keyword evidence="10" id="KW-0675">Receptor</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0770">Synapse</keyword>
    <keyword evidence="4 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="55"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="137"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="237"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="Ionotropic glutamate receptor C-terminal" evidence="17">
        <location>
            <begin position="211"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="18">
        <location>
            <position position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00034104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM00079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="CAG5107935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="425" mass="47859" checksum="4119FAD5D578DF0F" modified="2022-05-25" version="1" fragment="single">RADLAVASMTINYARESVIDFTKPFMNLGIGILFKVPSSQPTRLFSFMNPLAVEIWLYVLAAYMLVSFTLFVMARFSPYEWNNPHPCLAESDVIENQFNVSNSFWFITGTFLRQGSGLNPKATKRAPSRLFSFMNPLAVEVWLSMLGAYVVVSMSIWIVARLSPYEWVEPPPCPSCKCPLQGSHVSALEPDSDDIPLPKTVNDFSLSNSFWFTVGSLMQQGSDLNPKATSTRIVGGIWWFFTLIIISSYTANLAAFLTVERMITPIENAADLAEQTEISYGTLEGGSTMTFFRDSKIGIYQKMWRFMEAKRSSLFVSSYEEGIKRVLEGNYAFLMESTMLDYAVQRDCNLTQIGGLLDSKGYGIATPKGSPWRDKISLAILELQEKGVIQILYDKWWKNTGDVCNRDEKSKENKANALGVENIER</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HRU3</accession>
    <name>A0A8J2HRU3_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">T-complex protein 1 subunit alpha</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">CCT-alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HICCMSTLAB_LOCUS12150</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5106217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HRU3"/>
    <dbReference type="OrthoDB" id="496at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03335">
        <property type="entry name" value="TCP1_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.7.10:FF:000009">
        <property type="entry name" value="T-complex protein 1 subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.560.10:FF:000070">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012715">
        <property type="entry name" value="Chap_CCT_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002194">
        <property type="entry name" value="Chaperonin_TCP-1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="CHAPERONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00750">
        <property type="entry name" value="TCP1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00751">
        <property type="entry name" value="TCP1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00995">
        <property type="entry name" value="TCP1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 9" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAG5106217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="531" mass="56995" checksum="8CB006017A6522ED" modified="2022-05-25" version="1">MSGVTSALAVAGQRQSGAPVRSQNVMAVCAIANIVKSSLGPVGLDKMLVDDIGDVTVTNDGATILRLLEVEHPASRILVELAQLQDTEVGDGTTSVVIIAAELLKNADELVKQKIHPTTVISGYRLACKEACKYIQEHLTVSVEELGRDCLVNVAKTSMSSKIIGADANFFGNMVVDAANAVKINDGKGGHMYPIKAVNVLKAHGKSARESILVQGYALNCTVASQAMPKKIVNAKIACLDFSLQKAKMKLGVEVLITDPEKLESVRQREMDITKERIQKILNAGANVILLSGGIDDLCLKYFVEAGAMAVRRCKKTDLKRVAKATGAHFLTSLTNMEGDETFEASFLGEAAEVVQDVICDDELLLIKGPKARTAASIILRGPNDFYCDEMERSIHDALCVVKRVLESKTVVAAIAEFARSLLVIPKTLAVNAAQDSTDLVAKLRAYHNSSQTTVDHANLKWVGLDLIEGTVKDNKKAGVLEPAISKIKSLKFATEAAITILRIDDMIKLDPEQKQGKSYGDAMAAGELEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HRW7</accession>
    <name>A0A8J2HRW7_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Similar to chp: Chaoptin (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HICCMSTLAB_LOCUS12137</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5106191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HRW7"/>
    <dbReference type="OrthoDB" id="676979at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:001164">
        <property type="entry name" value="GH01279p"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050328">
        <property type="entry name" value="Dev_Immune_Receptor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24373:SF370">
        <property type="entry name" value="FISH-LIPS, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24373">
        <property type="entry name" value="SLIT RELATED LEUCINE-RICH REPEAT NEURONAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00019">
        <property type="entry name" value="LEURICHRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00364">
        <property type="entry name" value="LRR_BAC"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="18"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="30"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52075">
        <property type="entry name" value="Outer arm dynein light chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="14"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035153100" evidence="4">
        <location>
            <begin position="19"/>
            <end position="1219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAG5106191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="1219" mass="137362" checksum="402ECAF04EB23AA7" modified="2022-05-25" version="1">MFQFSLFLRILCLSLVQGQVFLPDMEIVTSSVSNCQEIVASNNDNTALDLSQAGIVRLRKSFINSSSITHIYLNDNNIWKVEDGAFDGLPNLVHVDLTGNLINFSELIFGDKIETLILDQAIRNDEHSFSIFDFNYESCQASGFRKRSSSSSNVIELTSDSKFENLKELHLRKNNIESIVLKNVDYLGKIMPKIIRLYLDDNKLTSLDFAKPFTPSLTHLYLNNNKMSEFKSSSLFNLRFLTVDGNNIKNLCGGYQYCVGMSLQGAENLEFFSISNNGLEEIEADAFKDLNSLKHLNLSYNYIIKIVKHAFDDLEALIQLNLDHNKLMNFPDICGLKNLEILSLQSNKIKAIGKISFCGLSNITKLNLSNNLISELDAEAFNSLLALKVLDLSGNMLEALPDDWISPELNLQYLYLNDNFFKSVASLSLSKNTVLEYLFISGNPFKSINLKDFPGNTINVNLMGNDILEIESKAFKGLPHLVYLNLSHNKIPFGKFDFAYQSALETLVLDHGFAYSNWENDNKIQLSKSTIFPKLKNLYLCGNHIINFILLSDVVALSEVMPNIAHLYLSENSLSSLNFLDKIPQTLTHLYLENNKISHFESSNKNNIKVLSIDKNGFKQLSDTKVTNGGLCLKNFVKLEELSVSNSDISTISLHAFDDSQNLQYLNLSYNKFSDFLNNPFNSLKNLTTLDLDHNLLRVVPNICALKKLQVLSLSSNKISFLSSSSFCGLPNLKKLTLSNNGLRTIGSDTFNNMFALEKLDLSKNMLTALPQNWIPAKMNLQYLYVNDNKFVQFSNLSLDSAKNLNSLITHLYLTDNNIWKIDEGAFDYLPNLVYLNLTGNLFPLEELNFGGESSIETLILDRAINQHNNLEYYGSNDDCSRVRNYRDQSLNVQNLFTLSISVKLPKLKKLYLRQNNIQSIDLGMGPPLTEIMPNVTHIYLSENSIDSIRFIDYLPATLTHLFLDYNLATNFEVESLKNLKTLTLDGNQIGRLCNSYEYCLGLTLKTAVNLENLSVSKSGLQEIESDAFDNLQNLKKLDVSGNQLHKIVKHTFDNLTNLTTLKLDDNQLVTLPDICSLENLEHLSVANNKIRAISKSTFCGLSKLKVLNLSGNALQEISVGAFDELVALEELDLSKNAFVSLPDEWLSPELSLRRLHLNNNMFKNLASLSLSKSKNLQYINIGDNPLTLIDIKILTTLPENTTANIVTAKEAETINEYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HSJ4</accession>
    <name>A0A8J2HSJ4_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">DNA damage-binding protein 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5 6">Damage-specific DNA-binding protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HICCMSTLAB_LOCUS12513</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Plays a role in DNA repair. May be a component of an E3 ubiquitin-protein ligase which promotes histone ubiquitination in response to UV irradiation. Histone ubiquitination may be important for subsequent DNA repair.</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the DDB1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5106944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HSJ4"/>
    <dbReference type="OrthoDB" id="433457at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.910:FF:000001">
        <property type="entry name" value="DNA damage-binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000070">
        <property type="entry name" value="DNA damage-binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000081">
        <property type="entry name" value="DNA damage-binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018846">
        <property type="entry name" value="Beta-prop_RSE1/DDB1/CPSF1_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058543">
        <property type="entry name" value="Beta-prop_RSE1/DDB1/CPSF1_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050358">
        <property type="entry name" value="RSE1/DDB1/CFT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004871">
        <property type="entry name" value="RSE1/DDB1/CPSF1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10644">
        <property type="entry name" value="DNA REPAIR/RNA PROCESSING CPSF FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10433">
        <property type="entry name" value="Beta-prop_RSE1_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23726">
        <property type="entry name" value="Beta-prop_RSE1_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03178">
        <property type="entry name" value="CPSF_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RSE1/DDB1/CPSF1 first beta-propeller" evidence="9">
        <location>
            <begin position="14"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="domain" description="RSE1/DDB1/CPSF1 second beta-propeller" evidence="10">
        <location>
            <begin position="396"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="domain" description="RSE1/DDB1/CPSF1 C-terminal" evidence="8">
        <location>
            <begin position="788"/>
            <end position="1097"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="752"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="752"/>
            <end position="770"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00031668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU368023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF10433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF23726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAG5106944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="1138" mass="125960" checksum="CFF3D52E50B2A3D9" modified="2022-05-25" version="1">MAHHYVVTAHKPTAVNACVTGNFTSPTDLNLILAKNMRLEIYLVTPEGLRPLKEVGIYGKIAEIKFFRPPHEKKDLLFLLTYRYNAMILECIGTGEDIEIITKAHGNVADRIGRPSDTGIKAVIDPKARVIGLRLYDGLFKIIPLDKDNPELKASSIRMDEQSVQDLDFLHGCANPTLIIIHQDINGCHVKTHEISLRDKEFVKTPWKQDNVEREAMMVIPVPSPICGAIVIGQESILYHDGTAYVAVVPPIIKYSTITCYARVDAQGLRYLLGDLAGHLFMLFLEQEKRPDGTSVIKDLKVELLGEVSIPDCITYLDNGVIFVGSRMGDSQLIKLITKADENGSYCVVMETFTNLAPIVDMAIVDLERQGQGQMVTCSGAFKEGSLRIIRNGIGIQEHASIDLPGIKGMWALKVGGGNFDNTLVLSFVGQTRILMLNGEEVEETDIPGFVADEQTFHTGNVSNDLFIQITPSSARLISSESKSVVSEWEPTNKRTISVVACNGRQVLCATGNDLFYMEIVNDKIIPKGFSTLQHEVACLDISPLDGCNEATIATVGLWTDISIRILTLPALEEINKELLGGEIIPRSVLMTCFEGNTYLLCALGDGSMYYFTLQKDTGLLSDKKKVTLGTQPTVLRTFRSLSTTNVFACSDRPTVIYSSNHKLVFSNVNLKEVNHMCSLNAESYPDSLALATDSTVTIGTIDEIQKLHIRTVPLGESPRRITYQESSQTFGVVTMRVDVQESNGVSIVRPSASTQAASTSNSNHVVSHNKPGHTSASEIGQDVEIHNLLIIDQHTFEVLHAHTLIPNEYAMSLLSTKLGEDPTSYFIVGTALVNPDETEPKMGRILMYHWNDGKLQQVAEKEIKGSCYSLVEFNGKLLASINSTVRLFEWTAEKELRLECSHFNNIIALFLKTKGDFVLVGDLMRSFTLLQYKTMEGSFEEIARDYNPNWMTAIEILDDDTFLGAENSYNLFVCQKDSAAASEEERQQMQEVGQFHLGDMVNVFRHGSLVMQHLGESSTPTQGCVLFGTVCGAIGLVTQIPPGFYEFLRNLEDKLTTVIKSVGKIEHNFWRSFNTELKVEACEGFVDGDLIESFLDLSQEKMAEVAMGLTIDDGSGMKKEATVDDLVKIVEDLTRIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HTM1</accession>
    <name>A0A8J2HTM1_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="19">Similar to Cdh23: Cadherin-23 (Mus musculus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">HICCMSTLAB_LOCUS13224</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5108412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6510378at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048513">
        <property type="term" value="P:animal organ development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048589">
        <property type="term" value="P:developmental growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001736">
        <property type="term" value="P:establishment of planar polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007163">
        <property type="term" value="P:establishment or maintenance of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048731">
        <property type="term" value="P:system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd11304">
        <property type="entry name" value="Cadherin_repeat"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000098">
        <property type="entry name" value="cadherin-23 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000124">
        <property type="entry name" value="Cadherin-related family member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000168">
        <property type="entry name" value="Cadherin-related family member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000039">
        <property type="entry name" value="FAT atypical cadherin 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000092">
        <property type="entry name" value="Protocadherin 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000118">
        <property type="entry name" value="protocadherin Fat 4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.60">
        <property type="entry name" value="Cadherins"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002126">
        <property type="entry name" value="Cadherin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015919">
        <property type="entry name" value="Cadherin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020894">
        <property type="entry name" value="Cadherin_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24026">
        <property type="entry name" value="FAT ATYPICAL CADHERIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24026:SF126">
        <property type="entry name" value="PROTOCADHERIN FAT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00028">
        <property type="entry name" value="Cadherin"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00205">
        <property type="entry name" value="CADHERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00112">
        <property type="entry name" value="CA"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49313">
        <property type="entry name" value="Cadherin-like"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00232">
        <property type="entry name" value="CADHERIN_1"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50268">
        <property type="entry name" value="CADHERIN_2"/>
        <property type="match status" value="12"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 14" id="KW-0106">Calcium</keyword>
    <keyword evidence="8" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 17" id="KW-0732">Signal</keyword>
    <keyword evidence="4 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035163644" evidence="17">
        <location>
            <begin position="37"/>
            <end position="1894"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="1728"/>
            <end position="1750"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="18">
        <location>
            <begin position="131"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="18">
        <location>
            <begin position="240"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="18">
        <location>
            <begin position="350"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="18">
        <location>
            <begin position="467"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="18">
        <location>
            <begin position="577"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="18">
        <location>
            <begin position="695"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="18">
        <location>
            <begin position="806"/>
            <end position="927"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="18">
        <location>
            <begin position="928"/>
            <end position="1031"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="18">
        <location>
            <begin position="1032"/>
            <end position="1142"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="18">
        <location>
            <begin position="1149"/>
            <end position="1251"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="18">
        <location>
            <begin position="1254"/>
            <end position="1361"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="18">
        <location>
            <begin position="1362"/>
            <end position="1482"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1811"/>
            <end position="1894"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="1811"/>
            <end position="1820"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="1830"/>
            <end position="1840"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="1853"/>
            <end position="1866"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00059331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="CAG5108412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="1894" mass="211440" checksum="538D4193BA5AB221" modified="2022-05-25" version="1">MMLTETMSLCGILMSLRKVRLKLFCVLICMVSPCLARNHPPQFLINGQTEIVVRLKEGPETPVGSLIYRLRGIDPDGDSLRFGVKDQPGADVIRVETVGTQEANIYLNKLLDRESLLLLVEDINDNVPTFRPHPTTLTVKEDSGPGILTTVEATDADEGPHGQVVYHLQELDGDNDVFSISTVSGKGVIRLAGKLDYEKKYLYQLRILAVDRAINGRINTGTTAILVKVQDVEDQPPEFIAMTPVARISENAKIGTSVLQVRAIDGDKGINNRVSYSISEGPRNLFDIDANSGLVFTRAQLDRESEDNGDGTFILEITVKEISRVVPTPSVTTEVTIILTDVNDETPRFRSDRYVAEINENAPPNTPVNFLGDSIPEVYDHDLGSNGTFQMFIGDDAGIFEVTPSRGINEAPFLIRVKNPSELDFEQRSVINLTLVAKEVALFHPKFSVVPVTIYIKDQNDNYPEFSKPVYEVSVPENCPAGTTVAWVQALDDDSGNYGSEGIRYTNLGGSIAYALKLNSTSGIITVKQTGPGFDRELVARHYLTVEARDDLGRGNRNTVQLVVNIDDVNDNAPVFVQNKYEVVLLENKAKFESPITVEAFDIDLNGTKNSEIVYSIVASEFSRNFTIDSRNGSVRPTYPMDFEALPMIPGHRESSIRPLKLTIRARDLGTPSLSSDVPFIVYLKDVNDNEPIFERAVYQKNIPEDLVGGTSILQVKAWDKDLSSPNNKLVYRIQNGAGDKFVISPESGLIKVAPGSNLDPDLTSPKTTKYALTVVAIDSGTDVQRSAQVLVNITIIDVNNKPPVFVDPGTVSIRENTQVGAYVHRIVANDPDIAPILRYRIDPNSSEARNEEGTLIRIQEYDYLAAFELNALDGLLRVVKLLDRERVETIKLGLVVEDLAAVKGSQSASAVLNVVIEDENDNNPKFRRPFYRRSVMENSKNGVHIASIVADDADKNRTITYSLEGPAEATDLVHLDSETGEMVVANKIDREVYSWLNLTVRATDSGVPQRASFSEVYIQILDENDNNPYFITDVTNITIIENTKIGTEVIQIEARDPDSGDYGKITYLLDHMSSQGRFAIHPETGVLSVVNEIDWEAKSNYVIIIEAWDNYQFGYTAGESRNAFKQIEVIVEDVNDNSPKMEVPDECITISEFHDIRDAIAVIKATDADNPASLNGQIMFRILTGNELGLFLLEQTDYWTVKIKAVSSLRGKFGNYSMLLEARDLGSPANQDNKYLKVCVTDYNDNPPVFLSPQHNTTIRVPENVTVGSTIIQVEAQDADTGVNGEVHYRLKQDLAGHWRTFQIDDKTGVVTLKQPLDRETQRMYEIRIEAYDLGIPTPLSTDLDLIIYVRNINDYEPQFLVDVFTVAFAEEQPPGSEIVDLPETIDRDEVDDLDDPPTQVCYFIVGGNNDGYFTLDPFSHKLTTAEKLDRETLEEHLLLVKATEDCSTMPENESFFDSADDTLLKVVITVNDINDNAPRFVSKVFTGGVTTEADFATEVIHIKVKLVINDQSFIRSSFEIYWNFFKQAIDLDAGDNAAVSYYQVGKIHMTLTEGLDDMNIQPFLVDRLTGAVTLNFDPQPRMKGYFDFMVLANDTDGLKDTSRVFIYLLREDQRVRFVLRQHPPEVRNRIDNFREILGNVTGAIVNVDEYKVHENQDGSVDRTRTDLYLHLVNRRDNSILDVSEVLELVDRNIEKLDGLFKDFNVLDTQPAESQAIVQIEQAGTTFWLLVLTLFLGALLIMCIAISLSQRASFKRQLKAANASPFTTNESEFIRGPGRVPNTNKHSVEGSNPIWMHAYENEWFKSDESFSHNSDRDSLDENALNNEEVVERNSGERIANENPYYTQPGPGSISSVESITANQSESCRESPIYQHQNPVPNNPLGKKVETTEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HTT0</accession>
    <name>A0A8J2HTT0_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Steroid 5-alpha reductase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS13378</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5108720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HTT0"/>
    <dbReference type="OrthoDB" id="67965at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010721">
        <property type="entry name" value="UstE-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32251">
        <property type="entry name" value="3-OXO-5-ALPHA-STEROID 4-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32251:SF15">
        <property type="entry name" value="3-OXO-5-ALPHA-STEROID 4-DEHYDROGENASE (DUF1295)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06966">
        <property type="entry name" value="DUF1295"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50244">
        <property type="entry name" value="S5A_REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="126"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="150"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5108720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="244" mass="27509" checksum="32CD4C2A29DAD076" modified="2022-05-25" version="1">MAVDILDEDHLAVSAIVTIGMQLIFFSIAATFQMDKVTDFAGGMNFAFWVYIVSLPVMIINSPRHRVPFAPKTMTTLDSAGTGLFIIGLLAETYADLQKFAFRQDPHNNGKWCDDGLWGVSRHPNYFGEIVLWWGIFIISINVIEGFEWFVIASPIFTTFIILFLSGMPLLERASDERYRDNAEYRQYKQSTSPLIPIPAAIYREVPGFMKFLLCCEFPMYNSLDVKPRSAVTESTSISLAAST</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HUA7</accession>
    <name>A0A8J2HUA7_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">phosphatidylinositol 3-kinase</fullName>
            <ecNumber evidence="2">2.7.1.137</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HICCMSTLAB_LOCUS13771</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12709"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57880"/>
            <dbReference type="ChEBI" id="CHEBI:58088"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.137"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the PI3/PI4-kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.137" evidence="2"/>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5109135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HUA7"/>
    <dbReference type="OrthoDB" id="67688at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005942">
        <property type="term" value="C:phosphatidylinositol 3-kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016303">
        <property type="term" value="F:1-phosphatidylinositol-3-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035005">
        <property type="term" value="F:1-phosphatidylinositol-4-phosphate 3-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032060">
        <property type="term" value="P:bleb assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043491">
        <property type="term" value="P:phosphatidylinositol 3-kinase/protein kinase B signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048015">
        <property type="term" value="P:phosphatidylinositol-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050920">
        <property type="term" value="P:regulation of chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05165">
        <property type="entry name" value="PI3Kc_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1070.11:FF:000001">
        <property type="entry name" value="Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.770:FF:000005">
        <property type="entry name" value="Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1010.10:FF:000008">
        <property type="entry name" value="Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1070.11">
        <property type="entry name" value="Phosphatidylinositol 3-/4-kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1010.10">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.70">
        <property type="entry name" value="Phosphatidylinositol 3-kinase, accessory domain (PIK)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015433">
        <property type="entry name" value="PI3/4_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000403">
        <property type="entry name" value="PI3/4_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036940">
        <property type="entry name" value="PI3/4_kinase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018936">
        <property type="entry name" value="PI3/4_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002420">
        <property type="entry name" value="PI3K-type_C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003113">
        <property type="entry name" value="PI3K_ABD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001263">
        <property type="entry name" value="PI3K_accessory_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042236">
        <property type="entry name" value="PI3K_accessory_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000341">
        <property type="entry name" value="PI3K_Ras-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10048">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10048:SF118">
        <property type="entry name" value="PI-3 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00454">
        <property type="entry name" value="PI3_PI4_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00792">
        <property type="entry name" value="PI3K_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02192">
        <property type="entry name" value="PI3K_p85B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00794">
        <property type="entry name" value="PI3K_rbd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00613">
        <property type="entry name" value="PI3Ka"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00142">
        <property type="entry name" value="PI3K_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00143">
        <property type="entry name" value="PI3K_p85B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00144">
        <property type="entry name" value="PI3K_rbd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00145">
        <property type="entry name" value="PI3Ka"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00146">
        <property type="entry name" value="PI3Kc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51547">
        <property type="entry name" value="C2_PI3K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00915">
        <property type="entry name" value="PI3_4_KINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50290">
        <property type="entry name" value="PI3_4_KINASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51544">
        <property type="entry name" value="PI3K_ABD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51546">
        <property type="entry name" value="PI3K_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51545">
        <property type="entry name" value="PIK_HELICAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PI3K-ABD" evidence="9">
        <location>
            <begin position="17"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="PI3K-RBD" evidence="11">
        <location>
            <begin position="187"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="domain" description="C2 PI3K-type" evidence="12">
        <location>
            <begin position="321"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="domain" description="PIK helical" evidence="10">
        <location>
            <begin position="494"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="domain" description="PI3K/PI4K catalytic" evidence="8">
        <location>
            <begin position="739"/>
            <end position="1023"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAG5109135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="1041" mass="120905" checksum="2B3562DBB0721B69" modified="2022-05-25" version="1">MVHIPKAYNYDFWVKTPSDDVELTCLMPNGVIIPLEVNRNTTFGEIKEDLWEEASKYPLHGTLKDAPSYVFSCINTNAEAEEIRDESRLCDVKPFCSVLKVIERECVKSDRNLDSQIGSLIGKGLHEFASLKNSEVNDFRWKLRLLGDEYAQARRNKQWEEKVRYQFRPRLAQTPDIPKNIESRLKDGNMVVVTKFENTETTYTFQISHDTTPYQLIVLILNKRANTLMSKGEKPNDFTLKICGQEEYLIGEHPLIQYTYIQDCISKDVSPTLITVSIRNVMIDNDYSLENPELDSLKRSRPTFSTLTLRKKGKHISALKLDNYFEFTVNGISRLNCDAAHRTVEVGVQAGLFHGGKSLCESRKTKEMTVSADGSCTWDETLKFDLRVKDIPKNAKLCFVLYELSKSGKGLKNRRLIKDSKQEYFINAMWWANTAIYDFKSQLKTGAMTLYTWTYAEEMQNEDLLHPLDKSVLYPTPEKLVEYAAKLRESSEDRSLELEANEQQWEQLKLLADRYPLHELHEQEKKTMWALRRQCLTKMPNLLPKLLQCVEWNDHREVAEATALIQQWPKLPVEKALELLDFAYADQNVRSFAVRCLKDLRDEELNLYLLQLVQALKHENYLSCDLTEFLLRRALDNQRIGHYLFWHLRPEMHVASVSVRFGLILEAYCRGAQQHMKHLKKQVELLNKLKNLSEQIKLRKDRKAALQYLHDFLQEEHCQEALSNVLNPLDPRYRLRRIRAEKCRIMDSKMKPLWLVFENSDTFGEDIYVIMKHGDDLRQDMLTLQMFKIMDKLWKEEGLDFRMNLYNCISTDHKTGMIEVVLNAETIANIQKEKNIFSATAAFKCGSLIAWLKDHNSTKSELDKAIEEFTLSCTGYSVATYILGIADRHPDNIMVKKSGQLFHVDFGHILGHFKEKFGVKRERVPFVLTNDFVHVINKGQAKKSQAPEFQRFQEYCETAFSVLRCHGGLIVSLFAMMISTGLPELSCEKDLNYLRDTLVLEMSEEEAQNHFRSKFNEALVNSWKTSLNWASHNVAKNNKTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HUC7</accession>
    <name>A0A8J2HUC7_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Similar to Putative ATPase N2B (Haematobia irritans)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HICCMSTLAB_LOCUS13848</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AFG1 ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5109212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HUC7"/>
    <dbReference type="OrthoDB" id="548867at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:003041">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005654">
        <property type="entry name" value="ATPase_AFG1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF040713">
        <property type="entry name" value="ZapE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12169:SF6">
        <property type="entry name" value="AFG1-LIKE ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12169">
        <property type="entry name" value="ATPASE N2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03969">
        <property type="entry name" value="AFG1_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG5109212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="458" mass="52682" checksum="F641B23FD3B4CE15" modified="2022-05-25" version="1">MACYYNLSRRLNKLYTVKLCVPKEKPLSICRKYTNKVLKNDSHADDNSPREVLKKKIANNELIQDDYQIKIVESLQQVYDDLKGYKPSKASSFLSKWLKSSNANKPPKGLYIYGAVGGGKTMLMDLFYNCCQIENKQRVHFNSFMLDVHAKIHQVKKTIKRDASETKLKPFDPIPPVAQMITEKTWLLCFDEFQVTDVADAMILKRLFTQLFTNGVVVVATSNRSPDNLYKNGLQRSNFIPFIQVLKDHCAIETLESGIDYRLKLGSGKDTKYFISGQDPEDAVDTIFKYLCSMENDTVRPKTLSFKGRNVTFKKTCGQIIDSTFEELCDRPLGASDYLEISQAFHTVIIRDVPLLNLRLKSQARRFITLIDTLYDNKIRVVISAAAAPNKLFVPEGDSEYTDEKRMLMDDLAISHGSDNHKSNIFTGEEELFAFDRTVSRLCEMQTKEYWEQWEQYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HUF2</accession>
    <name>A0A8J2HUF2_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS13877</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5109241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HUF2"/>
    <dbReference type="OrthoDB" id="6478865at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21261">
        <property type="entry name" value="BEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5109241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="242" mass="27807" checksum="55D4B8AC97439075" modified="2022-05-25" version="1" fragment="single">YNGVKITKLKLPLAVHNGTGPIELICGYRIGRHENGLVVKWFHDLEQIYQWIPPMPPQINGIISGLTEYLPENTNKPLSHSIIRLKKVNLAMTGVYTCKISTILEDIAESRKMTVYVPDQKLNIYADYYNNTHINLTCVAKGARPSPILTIIVDGKQLDNRSIRIENYRNYPWIKQEAIVSNYSNPAIIQCEITIPGTGYRKREKLIYYYNKQLERNHNLQLRPSLIMAITNVFLTFIFSNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MBE8</accession>
    <name>A0A8J2MBE8_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similar to Defensin (Galleria mellonella)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS3321</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5081565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MBE8"/>
    <dbReference type="OrthoDB" id="8109893at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051707">
        <property type="term" value="P:response to other organism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.10">
        <property type="entry name" value="Knottin, scorpion toxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036574">
        <property type="entry name" value="Scorpion_toxin-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57095">
        <property type="entry name" value="Scorpion toxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035150212" evidence="1">
        <location>
            <begin position="30"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5081565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="81" mass="9370" checksum="FC2CF66FA11EE066" modified="2022-05-25" version="1">MAKSCSSMLLLVCLTFLVIVSSPKNEVQADALIGRYYGKDKEFITDCDEECKQFGYRRGHWESFLNVKCWCVPKSFKQHPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2ME75</accession>
    <name>A0A8J2ME75_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Endonuclease/exonuclease/phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS4218</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5084868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2ME75"/>
    <dbReference type="OrthoDB" id="7700971at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47510:SF3">
        <property type="entry name" value="ENDO_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47510">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14529">
        <property type="entry name" value="Exo_endo_phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="1">
        <location>
            <begin position="190"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5084868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="636" mass="72091" checksum="CC7720130C2A8F65" modified="2022-05-25" version="1">MEFGKKRSLLLHLAWIPQALYKLCTLSHTSRSTARARKIRLRVRSKTVVPKLLKAILKTLSSPSAEILLVRKPSRWGKKDLIRLCLGIESETPGRRRVTRKGELALSSLSSRFDLPTAQTWFTDSAPSLPTALTKFNVVHSQAVKQHSVGRARGGIPIGINEAFNYTLLDISPWWICIKIQLDNISLGLCTVYFSPAQDLYYHLSLLQYMLNDVQENHHLDLLILGGDFNARVGLGNDFPSIMTEGSTLLPDRTSLDTTVNSRGTQLLDFADINGFVLLNGRTHGDIPAKYTFCSAKGKSVIDQVWVNLAGINFISQLRVLDIPSQSDHSPISLQLSLPSLFLPPRTSLSHISTGTKVKWLIDKKDTFNNAMRWSQKISIDFDKEDIDFINRNLIEAILDAAETTGLVKTYNRHTRSSEHKSCFDKDCLIAKKRLRAVLRIAKAASFDLSSLSEYISAKKDYKDILKNKTKNYQDLIIKEFADVKNTTQFWRTYNSYRRKNAYTLPLPVDTWNKVYEGIYPPRIVDNSLYFGVLDPVLDTAITFEEITCSISHLKNCKASGLDSIPGELYKNLPCNWLLYVQTLFNKILDKEIVPKDWAHVALVMLHKKGDQHDPSNYRSLAMINLITKIFTMIIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MFJ0</accession>
    <name>A0A8J2MFJ0_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HICCMSTLAB_LOCUS4775</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5088250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MFJ0"/>
    <dbReference type="OrthoDB" id="194358at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050663">
        <property type="entry name" value="Ankyrin-SOCS_Box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24193:SF121">
        <property type="entry name" value="ADA2A-CONTAINING COMPLEX COMPONENT 3, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24193">
        <property type="entry name" value="ANKYRIN REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="90"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAG5088250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="194" mass="21771" checksum="AD5EE97C0191CE85" modified="2022-05-25" version="1">MNDTRCTVQIYFKNFIVIPFTGICVITSYIKMTEELDCSTHHVNLLHKAVADDDIEEVQNLLDLGEDINAVCHYPLTFTKKKYGVFKTNTNCTPLHLAVSQNNKKIVELLLLNKAVVDIEANSQDSEEESSIIEMYFTRNPLLLAIANRNEDKNGADVNYKSSYGETALGLSLEINDQQLTEIILNAGADCKVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MGG5</accession>
    <name>A0A8J2MGG5_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Similar to mth2: G-protein coupled receptor Mth2 (Drosophila yakuba)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HICCMSTLAB_LOCUS5502</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G-protein coupled receptor 2 family. Mth subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5090145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MGG5"/>
    <dbReference type="OrthoDB" id="5854379at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007166">
        <property type="term" value="P:cell surface receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15039">
        <property type="entry name" value="7tmB3_Methuselah-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.180.11">
        <property type="entry name" value="Methuselah ectodomain, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017981">
        <property type="entry name" value="GPCR_2-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000832">
        <property type="entry name" value="GPCR_2_secretin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052808">
        <property type="entry name" value="GPCR_Mth-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023311">
        <property type="entry name" value="Methusela_ecto_dom_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46953">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR MTH-LIKE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46953:SF1">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR MTH-LIKE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00002">
        <property type="entry name" value="7tm_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50261">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 12" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="9" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="191"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="224"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="256"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="300"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="352"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="403"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="436"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 2" evidence="11">
        <location>
            <begin position="188"/>
            <end position="460"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAG5090145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="505" mass="57693" checksum="E9F05D382B528EE5" modified="2022-05-25" version="1">MAVTRHILQEENRILKSIFTYLLLSRIIFVNSLLEPASIISIFLNDSWTLEQYPKLPRVGKCCSLEEIMAKDENGMAKCTPADVPSYPIFSPYFSDFNKTGALAPGDKKDNFVAIIGDPCKHKRYMLEPEISSDDEHYLLLNGSIFSPHQVPSMLALGVDYCMDIIPERGLRTLVCFQEQDQVTADFRLTFYASGLLISVPFLILTIIAYCITPKLMDVHGKALCHYCGCLAVAFTTLAIVQLASAHLNDQFCVSIAFVIQFSFVACFFWLNVMCLETYLLLRRYIDTGNWAPTKPNELFFYYSLWAWTPPAILIIISMIANLSPTVPIAFVKPNFGSERCWFESDVNAMPYFYVPVGLLVIANVVLFAMTAVEITRHQRELDLRRLRENRESGRDERRTLSWLRRLFLVCLALFFLMGINWAMEVISWCAGGDPLTWSAFDFVNALQGIFVFGIFVLRKPIRYLVWYQVQKLRGIDTNEPEVASMDRCLLTVLNVERFSREGIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MGJ0</accession>
    <name>A0A8J2MGJ0_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS5548</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5090236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MGJ0"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5090236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="135" mass="15863" checksum="3EF9CA2805256FD6" modified="2022-05-25" version="1" fragment="single">CFSFLSVFRYVYCEKKNSKSCPVRGVKILNNPIEFPPSVRHTHAYDLLTIDVQSFKNALIAASKKHFYSIDDIYFNVSQSHVDEIKTRLTLKMVKPAMRNHQKKMAASLPMLNTYSERSRRISYRAYKFDKIFSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MGJ8</accession>
    <name>A0A8J2MGJ8_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS5563</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5090267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MGJ8"/>
    <dbReference type="OrthoDB" id="9974479at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5090267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="324" mass="37580" checksum="D430159529DA6DE2" modified="2022-05-25" version="1" fragment="single">MMLLSTCHSKMLSSMRTSREKRVFPDFHLYSEFRDLLYSEDWQQLRWHDGTSTVEVTVQNSDEENESLVFINNGNMQHLAASESLYITINSNFAIDTLPAEEILVVTSILNKNAFLCLFALIKTKDNNCYREIINQLVTILPTPTRIFGNFNAELHHHLGTVYPNAEIKGSFYSYYIIFFQSATDFGVFQNEDNEIFVRKLMALALLLDNKINIVYTAVKNAIPENQKNTYQNFLLNFEEKWLRNVGPHRISCFNNMLQLSTVPRATANVLMNSKINNQPVWTILRDGKRASRMTCLQLDYLISKNIMDQIVKNLKGRRPNYVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MIU1</accession>
    <name>A0A8J2MIU1_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="21">Dystroglycan 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="23">Dystroglycan</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="22">Dystrophin-associated glycoprotein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="29" type="ORF">HICCMSTLAB_LOCUS3929</name>
    </gene>
    <organism evidence="29 30">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="29" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="19">The dystroglycan complex is involved in a number of processes including laminin and basement membrane assembly, sarcolemmal stability, cell survival, peripheral nerve myelination, nodal structure, cell migration, and epithelial polarization.</text>
    </comment>
    <comment type="function">
        <text evidence="20">Transmembrane protein that plays important roles in connecting the extracellular matrix to the cytoskeleton. Acts as a cell adhesion receptor in both muscle and non-muscle tissues. Receptor for both DMD and UTRN and, through these interactions, scaffolds axin to the cytoskeleton. Also functions in cell adhesion-mediated signaling and implicated in cell polarity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <location evidence="1">Sarcolemma</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Cytoskeleton</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
            <location evidence="5">Nucleoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="24">Postsynaptic cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
            <location evidence="2">Extracellular space</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="29">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5083790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5990676at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016011">
        <property type="term" value="C:dystroglycan complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045211">
        <property type="term" value="C:postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042383">
        <property type="term" value="C:sarcolemma"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043236">
        <property type="term" value="F:laminin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007411">
        <property type="term" value="P:axon guidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002009">
        <property type="term" value="P:morphogenesis of an epithelium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0021675">
        <property type="term" value="P:nerve development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11303">
        <property type="entry name" value="Dystroglycan_repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1040">
        <property type="entry name" value="Dystroglycan, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027468">
        <property type="entry name" value="Alpha-dystroglycan_domain_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006644">
        <property type="entry name" value="Cadg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015919">
        <property type="entry name" value="Cadherin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008465">
        <property type="entry name" value="DAG1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030398">
        <property type="entry name" value="SEA_DG_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21559:SF21">
        <property type="entry name" value="DYSTROGLYCAN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21559">
        <property type="entry name" value="DYSTROGLYCAN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05454">
        <property type="entry name" value="DAG1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05345">
        <property type="entry name" value="He_PIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00736">
        <property type="entry name" value="CADG"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49313">
        <property type="entry name" value="Cadherin-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111006">
        <property type="entry name" value="Dystroglycan, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51699">
        <property type="entry name" value="SEA_DG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="16" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="14" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="15" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="26" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-0628">Postsynaptic cell membrane</keyword>
    <keyword evidence="30" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0964">Secreted</keyword>
    <keyword evidence="11 27" id="KW-0732">Signal</keyword>
    <keyword evidence="13" id="KW-0770">Synapse</keyword>
    <keyword evidence="10 26" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 26" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="27">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035156051" description="Dystroglycan 1" evidence="27">
        <location>
            <begin position="16"/>
            <end position="1336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="26">
        <location>
            <begin position="1197"/>
            <end position="1223"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S72" evidence="28">
        <location>
            <begin position="802"/>
            <end position="916"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S72" evidence="28">
        <location>
            <begin position="1046"/>
            <end position="1160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="25">
        <location>
            <begin position="29"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="25">
        <location>
            <begin position="314"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="25">
        <location>
            <begin position="585"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="25">
        <location>
            <begin position="1233"/>
            <end position="1336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="25">
        <location>
            <begin position="33"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="25">
        <location>
            <begin position="62"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="25">
        <location>
            <begin position="320"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="25">
        <location>
            <begin position="341"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="25">
        <location>
            <begin position="410"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="25">
        <location>
            <begin position="422"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="25">
        <location>
            <begin position="485"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="25">
        <location>
            <begin position="602"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="25">
        <location>
            <begin position="1233"/>
            <end position="1242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="25">
        <location>
            <begin position="1259"/>
            <end position="1275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="25">
        <location>
            <begin position="1322"/>
            <end position="1336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00024991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00026224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00030092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00031034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00034100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="28">
        <source>
            <dbReference type="PROSITE" id="PS51699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="EMBL" id="CAG5083790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="30">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="1336" mass="149018" checksum="50A73EBF3A661564" modified="2022-05-25" version="1">MKLLVLAFIIPLALGLTFQEDDLVFDDVSDDSQPISSVSPLINQPSEPHQPQPPQSQSHPSTGSKIIESTSQSPFPEANVTTTVGHVFRFKVPKHAFGGSVNHYEIRSSNNKPLPHWLFYDEATTTLLGVPAKKDVGQHHLSIKAYYTYGDVVESLFTVKVLPEKTDEVKHKDGKTHCRDSEEQTLMSILLDVKFDDLKPVKKVNAIEKLASSLGLHVSAFSMHGRSSKEESASEDSRVILTGPGNVKRRKEKHSTSIQWQVGCDGHLWKHQAELVKQIKKQAKDKTLAKVIQLPVFLWRVKTFSNDLIRSRREAGSGDYGRNSNRNHNNNHRGNSNNNNDNDDDYDDDNYDYDESYDEDRDDRDDLENEPITTVPPRPIESAEESHPHRHHHGQDTSISIKAEEEIDEHDIIPVIDRKYPESSPSTSTPTPTSRSTTEQTSTTQSTPQEETPKTPAPPTVSTVTVKTEPEEDATTDINDIISENNNNNNNNNNNNNSKQPTLEVETEFDTETDTDSETTVVPSTFLTTLPTSSTISASTEEIKATTTAPSTTAATVFAANDTIDEDFEFTENASEFPTVLTEITPLTTIPSAGPDTTELQTSPTPASTSPATSTESPTRPMTAQPSSTASPTPATSPTTSTSSSTTTTTTTTTTTTTTTPIPTTTTTVPPPTTVATTTEEVSTTEKIVYRVRNYPPRQDRRLEKIRVTAGKPLSYFIPANTFSDIEDGDTRNLRLSLFLKGSSLKNTHWLQFNQQTQEVYGLPLNEHVSVWNYDLFAADREGLNVSDRLDIYVQQHKLTHSANHDFSIYLRIDKRSRFPTSVDWELKIIQALAQLYGDKDPSSITVRTIQISEDQAVFTWTNDTVPPSSECPKDAINRLYHVLVASNDGDPSSLLQHHLGPEIRVKRVSFQGHGQCEYAFSKKPQAPEVSTQEPKVNDPPMPRNQVDHLEAQVGQLLIFRVPEDTFYDPEDGPTRHLRLSLLHGDRSAISPDEWLQFDVNNQEFYGVPMKTDPRRREYQLIAVDKEGAAATDNLVLEIKPAEASKASAEFTIKLGVDYDAFVTSAMMKKNFILRLRDLFGDKNTDAISLMTITQVGHKNTMITWRNTTLPTEYCPNKAIQRLSEVLFVKPDNKELTNRIERIMGMEFPVDQLTLTPMGICLGEFTRVHSHDGGDEDDERGGRRGSGARGGADNDDYLITFVLPAIIIAAMLVLAGIIACILYRRKRSGKMSVSEHADERQSFRSKGIPVIFQDELEEKPEPGDKAPVILKEEKPPLPPPEYLRSHDGADQPMLAQENSEEPYQPPPPFARTSDTTRQNRPKPTPTYRKPPPYVPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MKC9</accession>
    <name>A0A8J2MKC9_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Similar to Luciferin 4-monooxygenase (Photuris pensylvanica)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HICCMSTLAB_LOCUS5246</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5089458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10253869at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016405">
        <property type="term" value="F:CoA-ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096:SF149">
        <property type="entry name" value="AMP-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="233"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="6">
        <location>
            <begin position="40"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="7">
        <location>
            <begin position="456"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="6">
        <location>
            <begin position="576"/>
            <end position="916"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="7">
        <location>
            <begin position="968"/>
            <end position="1043"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="6">
        <location>
            <begin position="1114"/>
            <end position="1317"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="7">
        <location>
            <begin position="1391"/>
            <end position="1466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG5089458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="1483" mass="167755" checksum="1B7B90823AD4DA26" modified="2022-05-25" version="1">MEQKSGKEVPEAVFENGIWKGTKINFPEGYHRIGKRILAQLRKYPDFIGQIDGASGKKDTYQMMSDRSIRCALWLKKQGIKTGDVVGFCSKNHLDSCIPFFASFFMGAIFNPWWDSSLDEELVLYFLKTANPKVLFIDEESAEIIMKTLEKNNYALPVVVFGQKTGLLFFEDILKAQNDEQVTTFECTDTEAEEPAIIMYTSGTTSNPKGALHSNRSLAHIISHYPTDNTSQIILWFSTLCWISGIMVTLRSIFYKYTMINSHHTSEEDACRFIEKYKVTRIMMGTSFANRFSKRPNVWNYDLSSLSLLMVGGGVLSKEITKFLHKLFKNAEIHVLYGSTEFGITVVTGPNSPKVIAPKGLVSCGRALANVEIKIVDPETNKILGPNEEGELYCRAPTLLTCYWNNPLATEEVFDSNGWFCSGDLGYYDEDGDIFIVERIKELIKYRLHHVAPAAIENVIQELPGVAEVAVVAKPNLEDLEQPMAFVTRVPGMEITENEIHEAVEKKLHDKMKLRGGICFLDKMPYTTSKKIAKKELRRMAKALIPEPTYENGIWKGGKVEMPDGYYKIGERILNQFKKYPDFIGQIDGTTGRKDTYTDMGDRSIRCALWLKKQGVSPGDIVGVCSKIHLDSCIPVYASFYIGAIFNPWWDSCLDEELVENLIETAQPKVLFIDENYADVIIKTITKMGCSLQIVIFGKKNGYLSFEDVLKTQTNEDVEKFECTKVEPKDPVFLVYTSGTLGFPKGVLHSYHSVAHMLRYYADDDIPSIDLYFSRLCWISGTRTVLRSIIFKATMIVTRLWMGTPILNRFIKIKGIEKYDLSSVKLVSYGGAAANGQTIRMLPRLFKNADFSARYGATEVGTATIGSTRSDKFDSCGKVFFNVEIKVIDPVTNKILGPNEKGELCILSPKLMIDYWKNPAKIEEIVDSDGWYHSGDLGYHDKAGVFFIETRIKDSIRCYLFDVIPRAVENVIEGCPGVAEVAVVAKPSFEHYQVPMAFVTKIPGMHITEKEIIEFVEKNLSNEVRLLGGVCFLDKMPCTPSRKIAKHRLYAMARTISKQQTREIPKPVCVDRIWKGFKVSLPEGFFKIGEKIYTQFKKFPDFVAQEPFSIPDLVMYFVKTTNPKVLFCDEDNAEIIIKALKTMESSLPVVFFSEKFNMPFQDILKAPSAEEVNKFECTKIEAKDPMIILYTSGTMSYPKGALHTYQSFVSMISYYPPDTTPQIVLWFSGLCWMSGLLTVLRSIIAKATMIVYHNLSEEDACRLVEKYKVTRMSMGASTANRLSKTKEAWKYDVSSLKIVSYGGGIATKEVIEALKNLIMGPNEQGELCCRTLMLMTRYWNNPTATEEVIDSEGWYHTGDLGYYDEDGDFFIVERIKELIKYRLHHVAPAAIENVIQELPGVAEVAVVAKPSLEDLELPMAFVTRVPGMQVTETEIHEAVEKNLQDRMKLRGGICFLDKMPYTTSKKISKRELRAMAKDMVKKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MME3</accession>
    <name>A0A8J2MME3_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Mutator-like transposase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS6774</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5093375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MME3"/>
    <dbReference type="OrthoDB" id="7680010at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049012">
        <property type="entry name" value="Mutator_transp_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20700">
        <property type="entry name" value="Mutator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mutator-like transposase" evidence="2">
        <location>
            <begin position="76"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5093375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="260" mass="29578" checksum="2BBF9623AF4ABD61" modified="2022-05-25" version="1">MNKVTRKQLTLGARRKDRPKKRRRSFNGENTETDDSSFTSTSAKKLKGDDREHVPEEYTLQYSIIDFALVFSTLSSFVRCSNIIKNEDEDQLCNGKVQFKQCSKFGLGFKIVVECERCDPKYILSCQKIGRMYELNRRFFFVMRILGLGLAGCKKFCGLMDISSSFLNQSTYDFYIGKIYECIDTVTQTLFSSAAEEEKQLTSLENDLQDTTDVSVSSDGIWNKRGFSSLFGVTSLMGYNSGKVLDVLLKFSYVKAGKIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MN34</accession>
    <name>A0A8J2MN34_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Similar to sna: Protein snail (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HICCMSTLAB_LOCUS9362</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the snail C2H2-type zinc-finger protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5100056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MN34"/>
    <dbReference type="OrthoDB" id="6910977at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001325">
        <property type="entry name" value="zinc finger protein 200"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050527">
        <property type="entry name" value="Snail/Krueppel_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24388:SF38">
        <property type="entry name" value="PROTEIN SNAIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24388">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="167"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="195"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAG5100056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="258" mass="30632" checksum="D9A11428D997ACC6" modified="2022-05-25" version="1">MPRCLMKSIVRYHKENIYGDKLPRYSGASVSGISKKKSNNIKEAKGSNNINYSSLPIMTRYYFNKNNLLSDQVPLGLRLNLVEFDDNNHNDYSTSRINEFNLENNYNYSLYQNEIVDNFTEEKSEIQYVKSDISDNIFNNINQLDITGKEIQSDENRKNSKKNKVLHYCPYCNKSFDRPWVLKGHLRLHTGERPFQCPVCQKSFADRSNLRAHQRTRNHHEWQWKCQICLKAFSQRRYLDRHCPEACRKYRLSQKRGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MNE2</accession>
    <name>A0A8J2MNE2_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Endonuclease/exonuclease/phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HICCMSTLAB_LOCUS9681</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5100608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MNE2"/>
    <dbReference type="OrthoDB" id="7700068at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14529">
        <property type="entry name" value="Exo_endo_phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="3">
        <location>
            <begin position="444"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="33"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="123"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="196"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG5100608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="686" mass="77319" checksum="41B1B6C5BC6BB040" modified="2022-05-25" version="1">MLSSDTSRSKAGTVTVKQTSTDGIVEKKIKTGVNKKAFQAEKTPLKPSRPSDTADIETQESSYVENNSLTARPPEMATNNMSSDANVVQPDPDVGQILNEIAALRAEQDLKHTELKNKLESNLMKDQAAFTKLEESLSNLKNEISGTKTDLFKRISTVEENTVKINPIEGLKKLVSSMENQPAILTSSEGPLNKKISFLINKVEQLEKENKKTKITIAGLTLSFNNHSQEVKHFLTSNFNIDCSNIIVKKLRSYILVDLLDPSLKSTIFKAKKNKLTGTKIFINPDRTNKEQYIDWQCRQFCKQNYSEGKKVARKDNKQKLNQRYYPNGLRERSVEKLDNSSAELVKITFWNLHGYSNLELSSLREYSDIIAACETWTTLPLNLRFLEKYHNFWSDAVREHAVGRASDGLVTAINNRYNATILAKSPSWIFNKVEIGNTIIILGSVYFRKCLVLHSLLSSLQVLIDSIKATHTHDLFIIGGDMNARVGLLNPWPPEMFLGLHIHSARTSLDSAECDRGHQLLDFMLDNDFVLLNGRTNSDSPAQPTYDFHGTLIIDLVWANTSSLHYILDLEVILEPSLSDHRPVCVSIQVSSNSKPESCCTTPTCNTTKIKWDEKLENEFQSQLYSTRFPSNQSEAQPDDQYNWLQQSIFNAAENTGMVQRFNTAENTLSVRKSGKSPGPDQRTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MP30</accession>
    <name>A0A8J2MP30_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Similar to GPR52: G-protein coupled receptor 52 (Homo sapiens)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HICCMSTLAB_LOCUS9060</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5099431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MP30"/>
    <dbReference type="OrthoDB" id="6376512at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042277">
        <property type="term" value="F:peptide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032870">
        <property type="term" value="P:cellular response to hormone stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000258">
        <property type="entry name" value="G-protein coupled receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24241:SF170">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24241">
        <property type="entry name" value="NEUROPEPTIDE RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 10" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="46"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="83"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="125"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="166"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="224"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="258"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="9">
        <location>
            <begin position="25"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAG5099431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="313" mass="35554" checksum="76FF3218635755B8" modified="2022-05-25" version="1">MDEPSVEALMQASLIFVVGVAIILSNLLIIATFLNFRGPSEVIKYYLLSLATADLFCGLLVVPLSIYPALVRRWVYGDVVCRLVGYLEITLLAVSVYTFMWMSVDRYLAIRKPLRYETVQTKTRCQCWMAFTWISVAMMCCPPLLGFNKPIFDREAFICMLDWGNMAAYTITLSILVLGPSVITIVYTYTYIFSMMRKLRSGVPIHDKEYATALSENLSNPSHIMSFVLVMAFWLSWAPYAVLKIYSTVNGPPQVPFLQFAVVWFGILNSFWKAIILGTLSPQFRLAARVLCLTLCCRHRRLPPELLGLDDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MP53</accession>
    <name>A0A8J2MP53_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS9151</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5099621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MP53"/>
    <dbReference type="OrthoDB" id="25654at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5099621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="61" mass="7331" checksum="2C10F4D9B58A8D12" modified="2022-05-25" version="1">MGRQVRADDVVRSTDTTEEIQVETSDISNKFKFFETYKEPEKERKQFRITPPRDGQVKYKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MQP8</accession>
    <name>A0A8J2MQP8_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Chitin-binding type-2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HICCMSTLAB_LOCUS10482</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5101580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MQP8"/>
    <dbReference type="OrthoDB" id="6020543at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.140.10">
        <property type="entry name" value="Chitin binding domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002557">
        <property type="entry name" value="Chitin-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036508">
        <property type="entry name" value="Chitin-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051940">
        <property type="entry name" value="Chitin_bind-dev_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23301">
        <property type="entry name" value="CHITIN BINDING PERITROPHIN-A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23301:SF0">
        <property type="entry name" value="CHITIN-BINDING TYPE-2 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01607">
        <property type="entry name" value="CBM_14"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00494">
        <property type="entry name" value="ChtBD2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57625">
        <property type="entry name" value="Invertebrate chitin-binding proteins"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50940">
        <property type="entry name" value="CHIT_BIND_II"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0147">Chitin-binding</keyword>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Chitin-binding type-2" evidence="7">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="7">
        <location>
            <begin position="49"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="7">
        <location>
            <begin position="168"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="7">
        <location>
            <begin position="234"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="7">
        <location>
            <begin position="315"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="7">
        <location>
            <begin position="532"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="383"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="483"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="383"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="413"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="448"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="487"/>
            <end position="499"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG5101580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="609" mass="68286" checksum="034958AF36C4DB82" modified="2022-05-25" version="1">MCLVNYMVIRKCPEGMRFSNSSNDCEVITTDAECPNRSTGPVDDTKKCLEQCPDTNSIYQTILTAPEKCNKFCLCNWGKHIVFECPPSLHFNVETKTCDDSVSINANIAYKNTKLVQKFGPVINCPMILSIFLLGVTAQDEDNFKSENHLKMRTKIFWPEIHTTGNCIGKCPSLLEKLSFFTNLSHDDCNLYCLCLPGYQMVKQCPDNKHYSESLNECVEPEKAQCANKFDGCLGNCTLSHDGSSDGKLIAHQNCLKFCKCKPNGRLELYECAPNLHFSVENQSCMSPEDAKCNVEVNGSNETEEIQELKMEGCLGKCPETNSPNYTVIIPHSNCNYFCQCNWGKSVIIKCPESLHFNNQTKTCDSVINAHCVGNDVNYNLKNNESNSLEKNSEVTKSTSNEESNNVNSESNFGTTEPNSNDEAYNNEDIKSNSSKSDIDDFTDSIFNENTNTVNNKTNSTEENNNNNKDELNYIEKHNQATEMNSNEKNNLDIELNNDNNDDENSTEKTNENYDDTSSSINNQNNIDNGCIGSCPSSDSNKVFALVHMDCRKYCICVDGFPVAKNCSAGFYFDEIIRQCSNGTQVKSNQDFRPISNMQIGVKIKKIIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MR60</accession>
    <name>A0A8J2MR60_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similar to NOF: 120.7 kDa protein in NOF-FB transposable element (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS8360</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5096738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MR60"/>
    <dbReference type="OrthoDB" id="7600614at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="143"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="144"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5096738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="674" mass="77502" checksum="9EFB1951CEE97099" modified="2022-05-25" version="1" fragment="single">MFRSLTTMSYINRVKMMKSQNVFWHRLKLRNIILLISIFNICCVNINLNEYPSKCTIIMPATSAVSVDLAVNALIKHISYFTTEVLPVHSSPVWKNISEELNGLWKVPAVRINVRQDRRRILSIAREKYGIYFNNKENISPVCNTSTDSGDHSNTNDTNDDDIKADDDLLSDEGYNDDEFENFHVTISRKQWNLMKRDEPFIYKGRRYHGFEPGVWTNIISFALWEQYRLKFAFVFKHGKINKTSDNYYATITGYCKDGSCLNPIRGIIKNPPLDEGPVVITMKCRDTRNSKHADVKRPLNGIDATGGLVKKLTESGPNKSGYIFLYQIVINFDGTTVPSLTTNNGLQPRTFIRLDTAHFLHTVSRWKCFQSVLHKIVKSFFLYCVALMIDCKSLSSLEEIFTLILIVCRTEFEDSIIAIDDRMITPGEAKKTLEKLIATRDLSNDLNLDLNNIDFVEVDPDKTLVFEELSQKATDNKGWSVALLRWIDKVCRKTNTVIFTGKKLNTHYVPELYGNLVDNMKDFPLWSNVCTPETMLRPNSCFVETAFKDLKMTLSKKVKLPTSVIKFLKLHIDDILGGINIFRSKLTKFVVDHCDDLKTSKEENFYENWKGKGKNEAAMDYDWTSDYAMDVSDNIESNYPVTTSENTSEHIRNTQLAEDLNDSIIMLKRHEDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MR84</accession>
    <name>A0A8J2MR84_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Similar to AP3M1: AP-3 complex subunit mu-1 (Pongo abelii)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HICCMSTLAB_LOCUS10950</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the adaptor complexes medium subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5102308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MR84"/>
    <dbReference type="OrthoDB" id="870at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030131">
        <property type="term" value="C:clathrin adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14837">
        <property type="entry name" value="AP3_Mu_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1170">
        <property type="entry name" value="Mu homology domain, subdomain B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050431">
        <property type="entry name" value="Adaptor_comp_med_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036168">
        <property type="entry name" value="AP2_Mu_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001392">
        <property type="entry name" value="Clathrin_mu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018240">
        <property type="entry name" value="Clathrin_mu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028565">
        <property type="entry name" value="MHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10529">
        <property type="entry name" value="AP COMPLEX SUBUNIT MU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00928">
        <property type="entry name" value="Adap_comp_sub"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005992">
        <property type="entry name" value="Clathrin_mu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00314">
        <property type="entry name" value="CLATHRINADPT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49447">
        <property type="entry name" value="Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00990">
        <property type="entry name" value="CLAT_ADAPTOR_M_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00991">
        <property type="entry name" value="CLAT_ADAPTOR_M_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51072">
        <property type="entry name" value="MHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="MHD" evidence="6">
        <location>
            <begin position="160"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR005992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAG5102308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="407" mass="46068" checksum="BE7FAB406C497313" modified="2022-05-25" version="1">MINSLFIINSSGDVFMEKHWKSAVARSLCDYFFDQQRRVLSPEDTPPVIATPHHYLIIPPLFVIEFLHRVVDTFEDYFNECTETIIKENYVVVYELLDEMLDNGFPLATESNILKELIKPPNILRTIANTVTGKSNVSATLPSGQLSNIPWRRTGVKYTNNEAYFDVVEEVDAIIDRTGATVFAEIQGYVDCCIKLSGMPDLTLSFMNPRLFDDVSFHPCVRFKRWESERILSFIPPDGNFRLLSYHIGSQSIVAIPIYVRHNINLKESGGGRLDITVGPKQTVGRTVENVTLEIPMPKIVLNCTLVPNQGKYSFDPVSKVLFWDIGRIDVSKLPNLRGSITIQNGATFSESYPAINVHFTINQLAVSGLKVSGLDMYGEKYKPFKGVKYITKAGKFQIRIFITFIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MRZ7</accession>
    <name>A0A8J2MRZ7_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HICCMSTLAB_LOCUS12371</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5106661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MRZ7"/>
    <dbReference type="OrthoDB" id="6610549at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035324389" evidence="3">
        <location>
            <begin position="31"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="154"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="211"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="217"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="239"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG5106661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="292" mass="32547" checksum="DED4171E6574476E" modified="2022-05-25" version="1">MLEWLAQSGGTRLICLIIVPWFLLGHQVQGGPDPPELTTLEAVPDRGVKKFGDECKEDRECGFDGSFCDPRSKKCYCREEYPVTNHIDKCGIPANVNESCFFTEQCEEKVSQTECRDGRCICIFEKIPVLQPGGVFECIAEVKEEENLRYTDPAMIGILVAMALMFIIICVVLRLFSKARWRENRTIFNTPNARLMNVSLLRDNNKLLHAQERRGSRASQRGPSRQPSMASLRAHSPNGSQQGSRRGSRGSSGNASSISTAIRVNKSPPHHPNTLNDPVIESVTVEITEARA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MTT9</accession>
    <name>A0A8J2MTT9_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Similar to SCD5: Stearoyl-CoA desaturase 5 (Bos taurus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">HICCMSTLAB_LOCUS13826</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="12">The histidine box domains are involved in binding the catalytic metal ions.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the fatty acid desaturase type 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5109190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MTT9"/>
    <dbReference type="OrthoDB" id="9988030at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004768">
        <property type="term" value="F:stearoyl-CoA 9-desaturase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006636">
        <property type="term" value="P:unsaturated fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03505">
        <property type="entry name" value="Delta9-FADS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015876">
        <property type="entry name" value="Acyl-CoA_DS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005804">
        <property type="entry name" value="FA_desaturase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11351">
        <property type="entry name" value="ACYL-COA DESATURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11351:SF21">
        <property type="entry name" value="GH07782P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00487">
        <property type="entry name" value="FA_desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00075">
        <property type="entry name" value="FACDDSATRASE"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 12" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="8" id="KW-0408">Iron</keyword>
    <keyword evidence="3 12" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="40"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="159"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="domain" description="Fatty acid desaturase" evidence="14">
        <location>
            <begin position="41"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CAG5109190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="225" mass="26582" checksum="7C0A09F3A2958962" modified="2022-05-25" version="1">MSWQELKKNILWPNFFFMLTLHALFLYYAIIFPYLECKILLAWVLVTLVLAEFGVTAGVHRLWSHRAYKAKLPLRIILAALYHSAAQNSIVSWVRDHRVHHKYADTPADPHDSSRGLWFSHVGWLVMKEQPEVSQRRAEVNMSDVLADPVVRFFEKYHVPLKILLAFVIPIFIPVYIFNQSFKWSLISQLLIRYPMNLNITWTINSFAHKFGYRSYDKLLKYKIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MU62</accession>
    <name>A0A8J2MU62_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">ATP synthase F(1) complex subunit delta, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">ATP synthase F1 subunit delta</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">F-ATPase delta subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">HICCMSTLAB_LOCUS13206</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="15">Subunit delta, of the mitochondrial membrane ATP synthase complex (F(1)F(0) ATP synthase or Complex V) that produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. ATP synthase complex consist of a soluble F(1) head domain - the catalytic core - and a membrane F(1) domain - the membrane proton channel. These two domains are linked by a central stalk rotating inside the F(1) region and a stationary peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. In vivo, can only synthesize ATP although its ATP hydrolase activity can be activated artificially in vitro. With the central stalk subunit gamma, is essential for the biogenesis of F(1) catalytic part of the ATP synthase complex namely in the formation of F1 assembly intermediate.</text>
    </comment>
    <comment type="subunit">
        <text evidence="16">Component of the ATP synthase complex composed at least of ATP5F1A/subunit alpha, ATP5F1B/subunit beta, ATP5MC1/subunit c (homooctomer), MT-ATP6/subunit a, MT-ATP8/subunit 8, ATP5ME/subunit e, ATP5MF/subunit f, ATP5MG/subunit g, ATP5MK/subunit k, ATP5MJ/subunit j, ATP5F1C/subunit gamma, ATP5F1D/subunit delta, ATP5F1E/subunit epsilon, ATP5PF/subunit F6, ATP5PB/subunit b, ATP5PD/subunit d, ATP5PO/subunit OSCP. ATP synthase complex consists of a soluble F(1) head domain (subunits alpha(3) and beta(3)) - the catalytic core - and a membrane F(0) domain - the membrane proton channel (subunits c, a, 8, e, f, g, k and j). These two domains are linked by a central stalk (subunits gamma, delta, and epsilon) rotating inside the F1 region and a stationary peripheral stalk (subunits F6, b, d, and OSCP). Component of a complex composed at least by ATPIF1, ATP5F1A, ATP5F1B, ATP5F1C AND ATP5F1E.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATPase epsilon chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5108376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MU62"/>
    <dbReference type="OrthoDB" id="270171at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12152">
        <property type="entry name" value="F1-ATPase_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.440:FF:000002">
        <property type="entry name" value="ATP synthase subunit delta, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.15.10:FF:000004">
        <property type="entry name" value="ATP synthase subunit delta, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.440">
        <property type="entry name" value="ATP synthase delta/epsilon subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.15.10">
        <property type="entry name" value="F0F1 ATP synthase delta/epsilon subunit, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00530">
        <property type="entry name" value="ATP_synth_epsil_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036794">
        <property type="entry name" value="ATP_F1_dsu/esu_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001469">
        <property type="entry name" value="ATP_synth_F1_dsu/esu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020546">
        <property type="entry name" value="ATP_synth_F1_dsu/esu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048937">
        <property type="entry name" value="ATPD_C_metazoa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036771">
        <property type="entry name" value="ATPsynth_dsu/esu_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01216">
        <property type="entry name" value="ATP_synt_epsi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13822">
        <property type="entry name" value="ATP SYNTHASE DELTA/EPSILON CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13822:SF7">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT DELTA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02823">
        <property type="entry name" value="ATP-synt_DE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21335">
        <property type="entry name" value="ATPD_C_metazoa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46604">
        <property type="entry name" value="Epsilon subunit of F1F0-ATP synthase C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51344">
        <property type="entry name" value="Epsilon subunit of F1F0-ATP synthase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0007">Acetylation</keyword>
    <keyword evidence="12" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="11" id="KW-0139">CF(1)</keyword>
    <keyword evidence="4" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ATP synthase F1 complex delta/epsilon subunit N-terminal" evidence="18">
        <location>
            <begin position="39"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="domain" description="F1F0-ATP synthase delta subunit C-terminal" evidence="19">
        <location>
            <begin position="108"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00031669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00032372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00056834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00062932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00070799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF02823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF21335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="CAG5108376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="151" mass="15974" checksum="265884E87283ED23" modified="2022-05-25" version="1">MATLARTLRPAFRCLRSQARSYAEASGNEMKFTFAGANQVFDVPSFSGSFGILPKHVPTLAVLKPGVVTVYQDDGTTKKVFVSSGTVTINEDASVQILAEEAHPVENLDNSAARDILSKAQSQLNSASSEQDKAEAAIAIEVAEALVQASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MU73</accession>
    <name>A0A8J2MU73_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to Mettl7b: Methyltransferase-like protein 7B (Rattus norvegicus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS13236</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5108436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MU73"/>
    <dbReference type="OrthoDB" id="416496at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052356">
        <property type="entry name" value="Thiol_S-MT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45036:SF1">
        <property type="entry name" value="METHYLTRANSFERASE LIKE 7A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45036">
        <property type="entry name" value="METHYLTRANSFERASE LIKE 7B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="domain" description="Methyltransferase type 11" evidence="2">
        <location>
            <begin position="86"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5108436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="265" mass="30895" checksum="0C023B40BE50F885" modified="2022-05-25" version="1">MATCDIWIRNVISIYGLLLIIMLIIYYFVNSKWCKLTSYIYRLHLLGFEAECAEVAVPYKRRLFEPLDNLESYDKFLRFNNCIRVLEIGVKTGQNIQFYPNGTHLIGVDWNYKLKEYLTESDHAWQFSHIEIEKLIIGDGSCLKDIPNNYIDAVVTTRSLCSVSSVPEVLKEIRRVLAPGGVYLFLEHIPDTKDALTRWLQSFLTKTKIWPSLFGDCRLDSNPLKFIQSANFKSVEWEKIKLRGYVSQPYRLNLTCYHIMGTARK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2025-04-02" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MUE2</accession>
    <name>A0A8J2MUE2_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS8137</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5096292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="249703at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="179"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="319"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="644"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="892"/>
            <end position="1058"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1071"/>
            <end position="1174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1265"/>
            <end position="1295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1562"/>
            <end position="1661"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1687"/>
            <end position="1714"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1823"/>
            <end position="1915"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="24"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="187"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="215"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="324"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="346"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="361"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="377"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="664"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="675"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="714"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="736"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="782"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="892"/>
            <end position="902"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="933"/>
            <end position="984"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="986"/>
            <end position="998"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1071"/>
            <end position="1088"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1098"/>
            <end position="1137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1147"/>
            <end position="1167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1265"/>
            <end position="1274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="1590"/>
            <end position="1604"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1612"/>
            <end position="1622"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1639"/>
            <end position="1649"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1693"/>
            <end position="1708"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1823"/>
            <end position="1846"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1871"/>
            <end position="1889"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5096292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="2077" mass="230108" checksum="0703CF2A254C7869" modified="2022-05-25" version="1">MASREKKPLASSKSKQSKTNNDASLSSSPSRSNKNSNKNKSLPSQLFETVTPDRNNKSAIVLSSTLYRFRRGPISVRKSTGSIDRRISRLRSVPSLIDNKSSITTSTTTTTDNIGLDTSLYPGRRPKVSARKSCGATENYISRLRSVPSLNDNKSSTNIVLSNLKPKDNNKEQSIEVDGSLIDKNSDSTSCSSTSSTITSQSNSPKSNKKLKTVSPESQLKSAKVTNKLSERKKSVGKESLEDLKYLKTRKSSPAVVTTASEVKNSGKLKNSIDSTIDEVVAMVSDTEIEELAPVDPDNKLEGKITRSKKMLIEECDIKKELVEPEEEIKSDDEGAETLLKANQSSRRRMSQRSLRNGKLRQLDSTEEKKARRHADDETDNADDEPNNVESGQSEATENERDAETENNNNSEQVDRSVDGEAGGPNLRSKAKAKSTDTPITGEDISTIDSKTTTTTTNPAEEPIRKSSGFDLLKKDNCLLGKITIGDKQSLKARRSSLNIDVKKTMGPLYGSEKIDGVSPQSKLDKMVEDIKLNIAKSIESKIGSDILSLDKSLGITKNFDTPKIEEVVAPFNTSMQKIGVLNKITNDDEETKADGSKIQIATNSSTTNNSNNSNSVPKVADTAKEIEKLVMGDNIEDNQHISESAETSKNKDANDETALIKSDSAKKSHNEPDQSQSSSQSSESLLITATTEVVVEEVQEAVKREDKEEEDQNQEKEKEKEKEKEEEEKDTVCSNDEKVSGEELKEEKITVKPCESMTKETEEETLETISMEVERLVTEPLPSNLNDTQSNESEEDKNLEMDVELPENIVEAAENNEQVVKIQDVVKSNDQTNLDSEVIENVSLEESTMEIVEESVVNEEEIEDDIKLTTEIDDNDYELIEKVGDQVTEVKQEVKNEEKQKSVSPEPSLISQEENTNKTSEKAVASAIGIEVKSREEKSSDINKSGVEEGRRVLRARDKLRKSEKALKAAEASGEAKSDDLKINKASTNETGESTGMKSKDETETAVVVKIEEPEPITRGRRSREVKKRKELETSPQSLKSKRSRRDNKKLEQQKEETLLDNEVATINENKRSLSVDKLSKRIEGTKSLRVFSPSESARDKNNDNRSKSENDIETSKVGKTERLSRGRCDSIKPKESSVNPAGEQIEIKEANPRTDDDDVTKKESSSEDAAVPVIAVTEVSDNESKATKIQAENVLKDSDEASTSGESTSSVSFKILETPEEKVRKESILRMLGLESMEKAAERLEKAKREQYTGTLKTIIRVSKDKDKDKKQSRSPLKMVLKQGRNDGDGGDTSEFYTIQKELGTSGLGDSSSGANRKLSTNHRQSCGRPCADVCCYCFGKFGSLDTPMHLAQLKSDERREKILSAEGHLTTDSCLCDACYRHVDRKANMSPTNTSSKPQRVHRQLLVSKCNVKDCRNPARHTVKRRWIQKIKPSIQNQMKIDVTVEPNQHSSMYFCVDHYALIEKFLICALCTRRLTRNQAYVVTPSETNELNRLLEQQRVPVLVTSGTFLCKLCRYFVNMHFKFKDVESMKANNKAYCKSYRKRLLEIHNIDVTEDEDDELPQQGLSMKDKRKKSKNSLNKSGSSVGSGGGGNSASGTGGPSKFSVDNSDKSTSEKSTPEPVKSNPPATSQIDDTVNRDSDEQHPKASVTDDDTTTETQILDLESAVEKLKKRKALDQHLYSTTSPVFNNHNNNSNNNNNNSSSKLQRPYGNQSSFLRHLILLEKYYRSGDLVLAPNASRNAINYSTSVQNRLISYEGPEKVDEPITDPLPNEFSNSRRLSGGYLLERDRLATSTPSTSSLITTPPITTATPDKLSLSQLLQQQQQQKQQTQSSQQLNTKSNPPRIFKINTGVSIIKKPPPSLQRLNLPSSSGSNSSNSNIMTNSTANGSAKRKDGFPNKITGSTSGGKVIHMSEPDFKRLQSLKKQKMLSEKITTTSFPSATSTSTSTSLASLTNSLAVTNVNATNVQQLKSAQTVARQNFQFHEHIRMQQEMLNRQSRGDFEPLICDVRSLINENTPTQNLINNLNLPKSIQVTTKPPSNNPIPILPKIPKSLTCITLNDNQAAGKHAIDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MVY1</accession>
    <name>A0A8J2MVY1_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Protein HIRA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">HICCMSTLAB_LOCUS9320</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="1 11">Required for replication-independent chromatin assembly and for the periodic repression of histone gene transcription during the cell cycle.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the WD repeat HIR1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5099972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MVY1"/>
    <dbReference type="OrthoDB" id="1741719at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000417">
        <property type="term" value="C:HIR complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031491">
        <property type="term" value="F:nucleosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055410">
        <property type="entry name" value="Beta-prop_CAF1B_HIR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031120">
        <property type="entry name" value="HIR1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011494">
        <property type="entry name" value="HIRA-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019015">
        <property type="entry name" value="HIRA_B_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13831">
        <property type="entry name" value="MEMBER OF THE HIR1 FAMILY OF WD-REPEAT PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13831:SF0">
        <property type="entry name" value="PROTEIN HIRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24105">
        <property type="entry name" value="Beta-prop_CAF1B_HIR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07569">
        <property type="entry name" value="Hira"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09453">
        <property type="entry name" value="HIRA_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="9 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0677">Repeat</keyword>
    <keyword evidence="11" id="KW-0678">Repressor</keyword>
    <keyword evidence="8 11" id="KW-0804">Transcription</keyword>
    <keyword evidence="7 11" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4 10 11" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="CAF1B/HIR1 beta-propeller" evidence="14">
        <location>
            <begin position="33"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="10">
        <location>
            <begin position="85"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="10">
        <location>
            <begin position="128"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="Protein HIRA-like C-terminal" evidence="13">
        <location>
            <begin position="673"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="344"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="448"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="350"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="382"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="404"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="448"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="474"/>
            <end position="489"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU364014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF07569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF24105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CAG5099972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="777" mass="83973" checksum="1E794214B2C896C8" modified="2022-05-25" version="1">MKLLKPNWVSHDDFPIFSVDIHPDGKRFATGGQACVNCVRWSAGGLLASGGDDKVIMIWRYHGSGGSASFGGKPSVESWRCVSTLRCHEGDVLDLAWAPHSPWLASASVDNSIIIWDASNFPNIIAILKGHTGLVKGVTWDPVGKYLASQSDDKSLKVWSTTDWSETTSISDPFVECGGTTHVLRLSWSPDGQYLVSAHAMNGGGPTAQIIERGNWTYDKDFVGHRKAVTCVRFNSNIFQKKQGGSSKAREYCCLAIGSRDRALSVWLTSLKRPLMVINELFTHSVLDASWSPCGLRLAACSWDGTVAFMEFTQQELGRPLNPEEQSLVHGGFTVMEAPVLLNMKPPAPTTQSQPAQPVSNGFSPSVSSSPSPIKAPINKQIEMRTSDGRRRITPMFIPPPPDTVNSSESTDTTAAIKNTPTFSSTSQTKSSIVIEKRDDVVAPNVTTTTNMATPSTSAPGLTLKRRDPTTARPNHHHHHHHHHSRKPRLVNDKQGSIVFPALKPVGSLSHQAAHYAVTVTNNQNLAHLQVFRGTDSEPTWNLHLGYSAVALAASAAVIAVGLEDGSIHTFDPTKGSRPAPPLAPPAPLAKLHAVGNAVMVISCCGAVRVWEIGSTSKLIVSTSASHLAAFGGASTLVGSRTPRGPLSSLQEALNRTAGGIMPSPRPPHNGSSIVSYLEQQLLASKALGSQQEYIHWFMALISFLLTQDGLEKRLRIMLDDLMGPSHSTAAKSTWDPMILGIRKHKLLADALGVIGGHLRWQRLYLEYSEQLASLKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MWD6</accession>
    <name>A0A8J2MWD6_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">E3 ubiquitin-protein ligase CBL</fullName>
            <ecNumber evidence="12">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">HICCMSTLAB_LOCUS10419</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="12">E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 18">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 12">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="12">The N-terminus is composed of the phosphotyrosine binding (PTB) domain, a short linker region and the RING-type zinc finger. The PTB domain, which is also called TKB (tyrosine kinase binding) domain, is composed of three different subdomains: a four-helix bundle (4H), a calcium-binding EF hand and a divergent SH2 domain.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="12"/>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5101346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MWD6"/>
    <dbReference type="OrthoDB" id="7237699at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045121">
        <property type="term" value="C:membrane raft"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001784">
        <property type="term" value="F:phosphotyrosine residue binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030971">
        <property type="term" value="F:receptor tyrosine kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017124">
        <property type="term" value="F:SH3 domain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007166">
        <property type="term" value="P:cell surface receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0023051">
        <property type="term" value="P:regulation of signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000022">
        <property type="entry name" value="E3 ubiquitin-protein ligase CBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.930.20:FF:000001">
        <property type="entry name" value="E3 ubiquitin-protein ligase CBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000015">
        <property type="entry name" value="E3 ubiquitin-protein ligase CBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.20">
        <property type="entry name" value="Adaptor protein Cbl, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.10">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024162">
        <property type="entry name" value="Adaptor_Cbl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014741">
        <property type="entry name" value="Adaptor_Cbl_EF_hand-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036537">
        <property type="entry name" value="Adaptor_Cbl_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003153">
        <property type="entry name" value="Adaptor_Cbl_N_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014742">
        <property type="entry name" value="Adaptor_Cbl_SH2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024159">
        <property type="entry name" value="Cbl_PTB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23007">
        <property type="entry name" value="CBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23007:SF11">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE CBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02262">
        <property type="entry name" value="Cbl_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02761">
        <property type="entry name" value="Cbl_N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02762">
        <property type="entry name" value="Cbl_N3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13920">
        <property type="entry name" value="zf-C3HC4_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47668">
        <property type="entry name" value="N-terminal domain of cbl (N-cbl)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51506">
        <property type="entry name" value="CBL_PTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10 12" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 12" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="9 12" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 11 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Cbl-PTB" evidence="15">
        <location>
            <begin position="33"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="14">
        <location>
            <begin position="338"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="388"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="438"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="402"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="13">
        <location>
            <begin position="450"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="16">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU367001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51506"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CAG5101346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="499" mass="56855" checksum="CE78E4390A57226F" modified="2022-05-25" version="1" fragment="single">MSSGHSSRSSRAAHISSILQKLQGRFTDAMTPPKLSTDKRMLDKTWKLMDKVVKLCQHQRMNLKNSPPFILDILPDTYQRLRLIYSKYEDRMSVLHSNEHFCVFINNLMRKCKQAIKLFKEGKEKMFDETSHYRRNLTKLSLVFSHMLSELKAIFPNGVFAGDQFRITKSDAAEFWRERFGNSTLVPWKVFRHELNQVHPISSGLQAMALKSTIDLTCNDYISNFEFDVFTRLFQPWSTLLRNWKILAVTHPGYVAFLTYDEVKARLQKYCITKPGSYVFRLSCTRLGQWAIGYLYPDGRHVNPDLTWAVQPTPEEHIKVTAEQYELYCEMGSTFQLCKICAEHDKDVRIEPCGHLLCTPCLTAWQDSEGQGCPFCRAEIKGTEQIVVDPFDPRRTHRPGAQSASVSNASTPTRDLDPDTEDIIELCNGNCGGLICDDSDEEEDSSPASSPVPPRRIVPSPPLPPRRPSPSPTPNNHPRNSSRHLTVPKENAPPPPTVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MXN3</accession>
    <name>A0A8J2MXN3_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS11750</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="2">Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Complex I is composed of 45 different subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the complex I NDUFA12 subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5103919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MXN3"/>
    <dbReference type="OrthoDB" id="274641at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045271">
        <property type="term" value="C:respiratory chain complex I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007763">
        <property type="entry name" value="NDUFA12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12910:SF2">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX SUBUNIT 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12910">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE SUBUNIT B17.2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05071">
        <property type="entry name" value="NDUFA12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0249">Electron transport</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="2" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU363103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5103919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="142" mass="16961" checksum="0649D386A63EDF34" modified="2022-05-25" version="1">MSFIKGHIDLLVRLGKIIKQNGVNPLKVLGTLYRTDDLKFGKHIGTDKYGNRYYQNDFYFYGRNRWVIYADHVHMDYDASQVPPEWFGWLHYKTDLLPHEDPARVQRRWMIDHKENMSGTKEAYMPYSTTKPKVEPWKPPQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MZA4</accession>
    <name>A0A8J2MZA4_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Rab-like protein 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HICCMSTLAB_LOCUS13825</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Required for KRAS signaling regulation and modulation of cell proliferation. Regulator of KRAS prenylation, and probably prenylation of other small GTPases. Required for lymphocyte development and function. Not required for myeloid cell development.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5109189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MZA4"/>
    <dbReference type="OrthoDB" id="5914890at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000525">
        <property type="entry name" value="rab-like protein 3 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24073">
        <property type="entry name" value="DRAB5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08477">
        <property type="entry name" value="Roc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00041166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00045267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAG5109189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="222" mass="25339" checksum="16F000CEBE66DB92" modified="2022-05-25" version="1">MFSKSVGKTSLSHLICEQKPIRNPSWTVGCSVEVKLHEYKEGTPNQKTYFIELWDIGGSQSHQNTRQVFYNPTHAIILVHDLSNRKSQQNLQKWLQEVLSKEGNGSGGRYKNFDDFDPEKFVGSTQVPILVVGTKSDLIESKSSLHRRSSTIAEECGADEIFVDCLQVRSLAAGTTSSLKLSRFFDKVIERRYYLNRDVNSPEKRRLQAYTSSYPQKAYHND</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2N0K6</accession>
    <name>A0A8J2N0K6_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Chitinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HICCMSTLAB_LOCUS13678</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 18 family. Chitinase class II subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5109042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="76388at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004568">
        <property type="term" value="F:chitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02872">
        <property type="entry name" value="GH18_chitolectin_chitotriosidase"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000007">
        <property type="entry name" value="Acidic mammalian chitinase"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.50.10:FF:000001">
        <property type="entry name" value="Chitinase 3-like 1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.140.10:FF:000004">
        <property type="entry name" value="Chitinase 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.10">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.140.10">
        <property type="entry name" value="Chitin binding domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002557">
        <property type="entry name" value="Chitin-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036508">
        <property type="entry name" value="Chitin-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011583">
        <property type="entry name" value="Chitinase_II/V-like_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029070">
        <property type="entry name" value="Chitinase_insertion_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001579">
        <property type="entry name" value="Glyco_hydro_18_chit_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050314">
        <property type="entry name" value="Glycosyl_Hydrlase_18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177">
        <property type="entry name" value="CHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177:SF359">
        <property type="entry name" value="CHITINASE 10-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01607">
        <property type="entry name" value="CBM_14"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00494">
        <property type="entry name" value="ChtBD2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00636">
        <property type="entry name" value="Glyco_18"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54556">
        <property type="entry name" value="Chitinase insertion domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57625">
        <property type="entry name" value="Invertebrate chitin-binding proteins"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50940">
        <property type="entry name" value="CHIT_BIND_II"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01095">
        <property type="entry name" value="GH18_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0147">Chitin-binding</keyword>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6 7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="domain" description="GH18" evidence="10">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="9">
        <location>
            <begin position="90"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="GH18" evidence="10">
        <location>
            <begin position="177"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="9">
        <location>
            <begin position="663"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="9">
        <location>
            <begin position="758"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="9">
        <location>
            <begin position="829"/>
            <end position="883"/>
        </location>
    </feature>
    <feature type="domain" description="GH18" evidence="10">
        <location>
            <begin position="944"/>
            <end position="1313"/>
        </location>
    </feature>
    <feature type="domain" description="GH18" evidence="10">
        <location>
            <begin position="1331"/>
            <end position="1700"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="9">
        <location>
            <begin position="1771"/>
            <end position="1823"/>
        </location>
    </feature>
    <feature type="domain" description="GH18" evidence="10">
        <location>
            <begin position="1858"/>
            <end position="2226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="554"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="645"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="893"/>
            <end position="931"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="578"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="893"/>
            <end position="906"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="913"/>
            <end position="924"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAG5109042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="2233" mass="252200" checksum="92744A1E451C7BB8" modified="2022-05-25" version="1">MSYYEICSKLEGLWDHGRDRDGPYINFGDQWVAYDDPISIKIKVAYIKSTNLGGVSLSSLDFDDFVGICGDPWPILKVAARGLGLYDSPVDKCNMEETYSDRENCAGFFVCEQGNLYHGQCKDDQFFDSREKRCVKADPEMCNPGHLGRYTEQVDYLAALKERQRSQQLRLQRGSGPRVVCYVTSWALYRKDEGTFVPEHLDTRLCTDVIYAFAGLNPDTLLLQPFDPWADIEHGLYERITSSRDSRVLLAIGGWTDSTGDKYSRLVSSESSRKKFIESAINFLHAHNFDGLSFEWNYPKCWQSDCKKGPDSDRPNFTKFIKEMSRAFNTATPSLKLAVTLSGYKEVIDRAYDVQEISEAADFISVMTYDYHGAWESKTGHLAPLYAHPQDDYPYYNINWTVNYLIAKGIQKSKLVVGIPFYGQAYRLSQPERSNLGDPATGPGTPGEFTGQPGMLGYYEICERIKYRGWKTGSGPSAYFHDQFVAYDDVKSVAEKGAWIKDNGFGGAMAWTVDLDDFLNKCCKEPFPLLRSLNRALGKLRFYYFNYYRGENCQRPSEPVTPPPPTLTTHSDANDGVPRPTRPGSTSTTKSTTWPTWTEKTTKKPSSTTVNWQTWTWSTWYPTSSTTTSTTIKAPAWTEWTTQKPTTQKLTTQSVSTGSSSTGNSCNSGEYVPDPNDCNLYFRCVLGEFRRGSCTLGLHWDSAHNRCDWPATARCHQGVNQNVDKPWTQKPVQRPITTTTTTTKGPTTITTTTTTTTGKPCSHGQYYAVPDSCTQFLICVNDNLVKQQCGPGLNWNDAKKMCDWAFMNPCKDTPKKTSALMMKEMDSMNEPCTSGSYSGVPGDCKSYHACLWGRHEKFACAPGLHFNRESNICDWPHRANCEENPTTQHWWTVSSSPSTTTTTQTPWTPPPTTTTTTTTTTTSPKPLPSAEIDPTKVSPLSGYFKVVCYFTNWAWYRRGIGKYLPEHIDHTLCTHIIYGFAVLDYSELTIRAHDSWADYDNRFYERVVAYKKRGVKVSLALGGWNDSAGDKYSRLVNSPSSRRKFIEHTIKFIEKYNFDGLDLDWEYPVCWQVDCSKGPKSDKEGFAALLRELSAEFKPRGWLLSSAVSPSKTVIDKGYDVPALNKYLDWIAVMAYDYHGQWDKKTGHVAPLYYHDQDEVFFFNGNYTINYWIAKGASPRKIIMGMPLYGQSFSIHDPKAGTGLNSPASAGVAGEFTQAAGFLAYYEICDRIRNRGWKIFQDPERRMGPYAYKGNQWVSFDDSDMIRQKAQFVRDMNLGGGMVWALDLDDFRGRCGEGRHPLMQTLQLVLSEPPNKHDHRNHGMKHGPEEFKVVCYFTNWAWYRQEGGKFLPENIDSDLCTHVIYGFAVLDGTSLTIKPHDSWADIDNKFYERVVALKAKGIKVLIAIGGWNDSAGDKYSRLVNSPSSRTRFITHVTQFIEKYSFDGLDLDWEYPVCWQVDCTKGPASDKESFTALVKELSDTFKPKGLLLSSAVSPSKRVIGHGYDVAALAKYLDWISVMTYDFHGQWDKKTGHVAPLYVRPDDWEMTFNANFSIHYWMEQGAPAKKLVMGAPLYGQSFSLAERNQHDLNAPTYGGGEAGDSTRARGFLAYYEICERTLKRGWTVVQDPERRIGPYAYQGDQWVSFDDAEQIRLKSEFIKKLGLGGGMIWALDLDDFENRCGCEASPLLKTMNRVLRNYPAGPTCKVTGSKAPEVAPISSTEPISQKPSWEQTTSWDKWTVSTTHKPMPIDPDDSIEVIAGAPPPTMLPIGECDDKQFIPHAEDCSKYVLCNFGQLSEMTCPSGLHWNKDHCDWPENAQCKKKAEKIEESNAISQSDMPMGLPSQIQEVGEINRGSKKVICYFTNWAWYRPESGKYLPEDINPNLCTHIVYGFTVLDYDMLTIKMHDMWADVDNKFYERVTAYKSKGIKVLVALGGWNDSAGDKYSRLVNNPTARARFVKHAVQFVEKYNFDGLDLDWEYPVCWQVKCESGPASDKKAFALLVKELSQEFKPRGWLVSAAVSPSKRVIDHGYDVPMLNKYLDWIAVMTYDFHGHWEQKTGHVAPLYYYPGDEYDYFNANFSMRYWIEKGAAPSKLVMGVPLYGQSFTLSSSYDSGLQASAPRPGHAGTFTRSAGFLAFYEICEKVKSGWTITKDPLKRIGPYAIRNDQWVSYDDVTNVLAKASFIRELDLAGGMIWALDLDDFKGKCGCGKYPLLSALNRGLGGSAHGKDCT</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-24" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>B9W486</accession>
    <name>B9W486_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Cc_38K</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">Putative 38K protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">38K</name>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS5444</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2009" name="Science" volume="323" first="926" last="930">
            <title>Polydnaviruses of Braconid Wasps Derive from an Ancestral Nudivirus.</title>
            <authorList>
                <person name="Bezier A."/>
                <person name="Annaheim M."/>
                <person name="Herbiniere J."/>
                <person name="Wetterwald C."/>
                <person name="Gyapay G."/>
                <person name="Bernard-Samain S."/>
                <person name="Wincker P."/>
                <person name="Roditi I."/>
                <person name="Heller M."/>
                <person name="Belgahzi M."/>
                <person name="Pfister-Wilhem R."/>
                <person name="Periquet G."/>
                <person name="Dupuy C."/>
                <person name="Huguet E."/>
                <person name="Volkoff A.N."/>
                <person name="Lanzrein B."/>
                <person name="Drezen J.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <tissue evidence="2">Ovary</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5089969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FM201561">
        <property type="protein sequence ID" value="CAR31574.1"/>
        <property type="molecule type" value="mRNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FM212911">
        <property type="protein sequence ID" value="CAR82239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B9W486"/>
    <dbReference type="OrthoDB" id="7666388at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007827">
        <property type="entry name" value="DUF705"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010033">
        <property type="entry name" value="HAD_SF_ppase_IIIC"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01681">
        <property type="entry name" value="HAD-SF-IIIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05152">
        <property type="entry name" value="DUF705"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5089969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAR31574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="300" mass="35319" checksum="39ED4DEF746AC0D5" modified="2009-03-24" version="1">MNCLLYLYHDDKLRTEYSPNQYKKIISKRNDIIWALCRTYFEHVFKYDKTNRKTITITEPVSSSTKNKTSKFSEKKLMHQITLVLFCGNSQQMSDEYLDIQDLHHYTHYMKHKESLSYEVLNDRLRSLSETYESSGLTRASVVVLDLDDTLIDDSIRSRSRQLIDQLNEFKRIFNYVVLWSHGTSEHVRDSLRTVKIPENFFDVTITRPTLQSCGSNKGIGIVMAELYTRYQVRELTFSCIVDDLPSNFTDDYMLYVNVPGKSKVEDLTQFYTWALKEITKIKDYCESHDGNSYISTLNW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2E1T1</accession>
    <name>A0A8J2E1T1_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS987</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001114">
        <property type="protein sequence ID" value="CAG5074258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2E1T1"/>
    <dbReference type="OrthoDB" id="7646902at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032062">
        <property type="entry name" value="DUF4803"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47890">
        <property type="entry name" value="LD24308P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47890:SF1">
        <property type="entry name" value="LD24308P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16061">
        <property type="entry name" value="DUF4803"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035248817" evidence="1">
        <location>
            <begin position="18"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5074258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="399" mass="46043" checksum="A3B3BC9497E426D0" modified="2022-05-25" version="1">MNIINLVLIYFLLSVESSFVHYKYIQKRDPEMHRNDVTFGRLTFLKGQLFDEQYLSKNGQCTGRCSDYEDTYYHHNEHYNKSIVNKLFQCNGRIVKCKDVVNFDATVTLHVDNMMYRFKPNKDGSDFSVRKAEGLHDRQHHHLYKDHDLYTNYPLSSHSRCVTCKCYCDDTHSKKSVRSFCLDTIQSLVEEGYVITGLRLVIRAKMVHLEIQQGQLVNGLINQSTVHWSIKNWCTMPGPMNYNSRAFQLDEVILPEDQVLTGVQFNRYDPKTKVYGFSVGRFSLGAIGTTVDSTGNLDIENWFPHHKIQGKRKVLLISDLNISLIPPSGSEEISTPNKHYIKFHPSDWKYDFAQHMIPFLDFQEVVTEPASPISGAGIYYKSRRGFGGFIAPKIIVKTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2E7Z7</accession>
    <name>A0A8J2E7Z7_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Tollreceptor6Tollpathway_Cc</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">HICCMSTLAB_LOCUS2274</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Toll-like receptor family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001117">
        <property type="protein sequence ID" value="CAG5076775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2E7Z7"/>
    <dbReference type="OrthoDB" id="2015831at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038023">
        <property type="term" value="F:signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000198">
        <property type="entry name" value="Blast:Protein toll"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000418">
        <property type="entry name" value="protein toll"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10140:FF:000021">
        <property type="entry name" value="Toll receptor 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10140">
        <property type="entry name" value="Toll/interleukin-1 receptor homology (TIR) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000483">
        <property type="entry name" value="Cys-rich_flank_reg_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000372">
        <property type="entry name" value="LRRNT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000157">
        <property type="entry name" value="TIR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035897">
        <property type="entry name" value="Toll_tir_struct_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24365:SF541">
        <property type="entry name" value="PROTEIN TOLL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24365">
        <property type="entry name" value="TOLL-LIKE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13676">
        <property type="entry name" value="TIR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="19"/>
    </dbReference>
    <dbReference type="SMART" id="SM00082">
        <property type="entry name" value="LRRCT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00013">
        <property type="entry name" value="LRRNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00255">
        <property type="entry name" value="TIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52200">
        <property type="entry name" value="Toll/Interleukin receptor TIR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50104">
        <property type="entry name" value="TIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0675">Receptor</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 12" id="KW-0732">Signal</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035326084" evidence="12">
        <location>
            <begin position="25"/>
            <end position="1228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1015"/>
            <end position="1038"/>
        </location>
    </feature>
    <feature type="domain" description="TIR" evidence="13">
        <location>
            <begin position="1068"/>
            <end position="1200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CAG5076775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="1228" mass="138364" checksum="FB6E85A65160512D" modified="2022-05-25" version="1">MSYRWLALDHLLVAWIWITSLSLSSRSSVLAVTSSPSSLKYDLPAQCTIQQETWLSCVHTHWGSSHLNISRVLGEYVTALTIICEDNLQASIRSKENSGAEGDLEAAKLVEEYSHLWRLKDLKVLGCQVRSWSGKVLAGFHDLRNLTVRGANQDRKNQDVFELEKGAFEITRLIEKMDLSGNNIWQLPEGVFCPLTSLVTLNVSWNMLKDVAELGFSDYSVGVSKRDVDSAPVVTQITCSLDIQSLDVSNNQISVLPSHGFSSLQRLRTLNVSGNVIRVVDDAALKGLRSLEVCDLSSNRIVALPAGMFEDATNTLKELRLQNNSISALAPGLLINMSQLVTLDLSRNMLTSSWLDGNTFAGLVRLVLLDLSRNKINKIDPELFKDLYTLQILNFQFNEIEIIPADTFSPMRNLHTLELSHNRLTYLDAYSLNGLYVLSLLSLDSNALEGIHPDALRNCSNMQDLNLSGNNFEYIPIALKDMRLLRTLDLGENQIKTLDKPGFRGMTSLYGLRMIGNEIVNVTRGAFAELPKLQILNLARNKIEYIEYGAFASNETLQAIRLDANYLQDMTGVFANTPGLLWLNMSDNQINHFDYALLPEKLQWMDLHKNKIQDLGVAPSNLHLQTLDVSFNELTRIDPKSVPDSIELLFVNDNKIHTVQPKTFYDKINLTRVDLYANQIVKMDLSALQLSQIPETRALPEFYIGGNPFICDCTIEWLQRINSLSLRQHPRVMDLELVYCRLPYNRHRSFVSLLEAKPSQFLCTYKAHCFALCHCCDFDACDCEMTCPSNCTCYHDQSWSANVVDCSNSDYKTLPGRLPMDATEVYLDGNNFSELTSHSFIGRKNLEVLYVNDSNIITIHNHTFSGLKRLVVLHLENNRIGRLNGPELIPLENLKELYLQNNLLTYIDNGTFNALTHLEVLRLDNNKLKTFALWQLSLNPYLVDISISSNPWSCECGFLDQVRDWMTKNQVKISDWKRVTCELGMPINLVVNGTVVNCAALTGTTSAIETRQLEAYLPLLLATAVLFFAMVALICGAFRHRRTLRAWAASRCGLRACYKTAAFEDREKPFDAYISYSAVDENFVSRVLVPGLESSYRLCLHYRDLGAGANVADAVAEAADSSRRTILILSRNFLHGEWSRFEFKAALREALRGKGRSVILLLVGGVCPRDLDADLRKRISSHTVLVWGDKLFWQKLKFAMPDVSPIPVLERPLPLPPPPPPPSQHLWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2EB51</accession>
    <name>A0A8J2EB51_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Similar to chchd4-a: Mitochondrial intermembrane space import and assembly protein 40-A (Xenopus laevis)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HICCMSTLAB_LOCUS795</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001114">
        <property type="protein sequence ID" value="CAG5074023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2EB51"/>
    <dbReference type="OrthoDB" id="7481291at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015035">
        <property type="term" value="F:protein-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045041">
        <property type="term" value="P:protein import into mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.2900">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039289">
        <property type="entry name" value="CHCHD4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21622">
        <property type="entry name" value="COILED-COIL-HELIX-COILED-COIL-HELIX DOMAIN CONTAINING 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21622:SF0">
        <property type="entry name" value="COILED-COIL-HELIX-COILED-COIL-HELIX DOMAIN CONTAINING 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="8" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0811">Translocation</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="114"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="25"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAG5074023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="146" mass="16585" checksum="177CFE725807E71A" modified="2022-05-25" version="1">MSANNKEEKDSNNLSFNKEEKPPASKNNQSESESSPGLILSSGEINWDCPCLDGMASGPCGSEFKESFLCMFNSNTNEEQDNLECLTSFKNLFTCMSEYPDFYREKGFSEDLLSMKKEPEKSAENEEDDKKKNQKQNKNDKTESKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2ECH6</accession>
    <name>A0A8J2ECH6_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Similar to SAAL1: Protein SAAL1 (Homo sapiens)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HICCMSTLAB_LOCUS2438</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SAAL1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001117">
        <property type="protein sequence ID" value="CAG5077379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2ECH6"/>
    <dbReference type="OrthoDB" id="2156856at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052464">
        <property type="entry name" value="Synovial_Prolif_Regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23424:SF23">
        <property type="entry name" value="PROTEIN SAAL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23424">
        <property type="entry name" value="SERUM AMYLOID A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG5077379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="380" mass="43856" checksum="443E690287A20AA4" modified="2022-05-25" version="1">MSNEEAVSGIEQLNIADNELMVANADNINEEPWSTDLETDFCYLWDMTTEKDIVDFLCQNNFLSVSEFVIDNAPEPRCREIIVGILGNLCSQPTAFTRITNTPTLVTKLLSLMSSDDTETLIQVLRVLQAGSRDMQITITSPWREYLLYSKPLADALTFIFNSSTNSQLLRESLALMHTIATNTIFFNEIFDINPLLVGLVETFDQLMPSEQEEEAAEDDENESNDQVVIERWLEIIVKILERQSTTRINNYKDIIRVVIKILGKLEENMIPMDENKASSIYDCVAIANWLKKHRYHVDIKFLCPLTKIMIKLDDEISKQQENDKEIMVDLLKHLHRYWLGVYGASDELITDEYLSTCPSEVSRYLMNYIFNGTRHYNKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2ECU7</accession>
    <name>A0A8J2ECU7_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS1671</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001116">
        <property type="protein sequence ID" value="CAG5075517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2ECU7"/>
    <dbReference type="OrthoDB" id="7699899at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="140"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5075517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="265" mass="30186" checksum="94CAF33E2246C296" modified="2022-05-25" version="1" fragment="single">LNFIQINNQQLCDLLQFKFIGKSTMPLTAYNHIMADQPDEPMDLIVLPPRISKAQKQREYRQRIAASRTSAQVIAARKSDAKRQRNRRLRKAANLVRVSSSLESTTALSSHSGARSNDVQTGAQRQLTHQQRRTLAAEPTQITVQPGTSSDQIEVQQAQSTWNTKWAYSIVRFKSTFLDNDFGYACSVCDRLWFKNELKPITAAQLEVISKWFIKENRLLCREEYEMVCNTCKRSLNKKSMPPLAKVNGFSYPDEPPGLPPLDPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2GZ47</accession>
    <name>A0A8J2GZ47_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS11</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030000095">
        <property type="protein sequence ID" value="CAG5070422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2GZ47"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5070422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="65" mass="7904" checksum="D292A23A26E44B5E" modified="2022-05-25" version="1" fragment="single">IGINQNTQKKPVLTRRRFSFKEKLKILQQLENNSMITVCKNFHVNEFTVPENGKNKMYRKYFKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2GZ83</accession>
    <name>A0A8J2GZ83_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS161</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030000856">
        <property type="protein sequence ID" value="CAG5072523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2GZ83"/>
    <dbReference type="OrthoDB" id="7615572at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5072523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="98" mass="11300" checksum="BC5CA411174E045B" modified="2022-05-25" version="1" fragment="single">MLNSFAHSGNKKIREILPATSLQDWFSQHVYDKLLQRIEDFEHEGSGWSLLGPNSLMVTMSRFTPTQVGNSTFVRLPRDIIRKNAVTNIQNNDEFCFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2GZE6</accession>
    <name>A0A8J2GZE6_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS434</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001114">
        <property type="protein sequence ID" value="CAG5073491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2GZE6"/>
    <dbReference type="OrthoDB" id="7555294at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054722">
        <property type="entry name" value="PolX-like_BBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22936">
        <property type="entry name" value="Pol_BBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CCHC-type" evidence="2">
        <location>
            <begin position="57"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="160"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="161"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="197"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="214"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="230"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="251"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="286"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="304"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5073491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="313" mass="34798" checksum="EF54E7BD1624FA82" modified="2022-05-25" version="1">MRSKDDLPNTEVLIGKIMDENKSRAVNTAVDNNALYAGNRQSSNQRRNNPKQKKSYPCYICGSLEHWASKCPQRPKGTVKNVSANFENLYVEVASTEEVNNVTSTSRWCLDSGCTTHMCANEEMMEDLQKCTATLNMANTALTTAKAKGTASRNVEQMDLEYMHPEEDTEPRRETRNERVHQEPEMGPPKRAPGRPAKQKSGKLGRPKKLYRYVSMSSVASSNASSHEGDVDEPMEQEADGPDDVFYQASEENRGEKRPLDTSLVQIDKRARSEMGGSGAGTLTNDVEDLEDEDEPIERQSHVRGGGGPDKSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2GZI5</accession>
    <name>A0A8J2GZI5_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transposable element P transposase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HICCMSTLAB_LOCUS616</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001114">
        <property type="protein sequence ID" value="CAG5073811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2GZI5"/>
    <dbReference type="OrthoDB" id="7312725at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048367">
        <property type="entry name" value="TNP-like_RNaseH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048365">
        <property type="entry name" value="TNP-like_RNaseH_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47577:SF2">
        <property type="entry name" value="THAP DOMAIN CONTAINING 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47577">
        <property type="entry name" value="THAP DOMAIN-CONTAINING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21789">
        <property type="entry name" value="TNP-like_RNaseH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21787">
        <property type="entry name" value="TNP-like_RNaseH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transposable element P transposase-like RNase H" evidence="2">
        <location>
            <begin position="324"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="domain" description="Transposable element P transposase-like RNase H C-terminal" evidence="3">
        <location>
            <begin position="651"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="556"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="556"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="597"/>
            <end position="610"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF21787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF21789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG5073811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="935" mass="107033" checksum="302A521FCFD63578" modified="2022-05-25" version="1">MSIEITRQAKVLSNDNDQVRLAVKRRLSYPDNNVTIKRQKKFEHEIDCNRQMNRSNDAEVLSIIITLNEQFPIAWTFVPGINQLIAIQLDRVKLNERIRLIINDDQSVLVTYSEHYKKKIDVQIKSVNDLINFIKSMELKTLCTGTGYDLKNFSLKCHGDVSDIYKRSQATPRCPECRKLRVRLLKLKKGQNLNIADKVEVTSKAINLGLVKKTKRIKKQLQSCSSKLRDIQRKTKTIYKGEFNKKLSLLPKQQQITVRMCFENVNKKGPTGKRYEVEWIYECLLIRMKSTCTYNMIRARNIIPWPTIDTLSKYIGKISSSIFGFLPETFEVLRKKASSMAPEEKIGQISADEVKLMENIEYNKKIAEYSGFVDLGKYTTESDKDVAGDHALVFMFVPYRGSSAQPLGCFITKNSITSEVLHKLFLECIILVENAGFHVNLIVTDAAQWNRGVWTKLGVGPNNNSCEHPCDSSCRLWLYSREVRCAMTVLRENGNEKFEGSEPTEKFIKIIDDGIQAMTSHDAKNALYFKDTCEQQQAIRTLLKFLEDWEKMYTHTKTPNASTPKNSTPKNTVSKKITPRQSISKNSTLNQVIPQNTISKKATPKSTSKKNSFPISASTISGFKVTLRAALQILSELHHNYGYDYLITSRLTQDNLERLFSIMRYSCGANDHPTPQQFGQVFRLYCCNTMIKPPKGSNVTGVELLQTLMKTEDSLKMSRQPRMEWLEKIDKMLERAVPIGDIWNDNSSNDANESSVSSIDLNASESLTTEPTSRIQTTLESLEHHDYDVVSTSREVQAYMAGYIVRKMKYKCKCSSCFYTLQSSNDEPNCRDRFIDLMEKYGGLSRASDNLFQLTMQLEAAFLDVVGRVGLSRGTINKILDRIESMLPQLSFVGCGIHQLEITKDIIDFYITMRLYFLGKTFNKRNQLKREKMKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2GZN3</accession>
    <name>A0A8J2GZN3_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Similar to Kdm8: Bifunctional peptidase and arginyl-hydroxylase JMJD5 (Mus musculus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HICCMSTLAB_LOCUS842</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001114">
        <property type="protein sequence ID" value="CAG5074070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2GZN3"/>
    <dbReference type="OrthoDB" id="47172at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051864">
        <property type="term" value="F:histone H3K36 demethylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006488">
        <property type="term" value="P:dolichol-linked oligosaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.650">
        <property type="entry name" value="Cupin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041667">
        <property type="entry name" value="Cupin_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003347">
        <property type="entry name" value="JmjC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013969">
        <property type="entry name" value="Oligosacch_biosynth_Alg14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12461:SF106">
        <property type="entry name" value="BIFUNCTIONAL PEPTIDASE AND ARGINYL-HYDROXYLASE JMJD5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12461">
        <property type="entry name" value="HYPOXIA-INDUCIBLE FACTOR 1 ALPHA INHIBITOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08660">
        <property type="entry name" value="Alg14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13621">
        <property type="entry name" value="Cupin_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51184">
        <property type="entry name" value="JMJC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="66"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="JmjC" evidence="8">
        <location>
            <begin position="222"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAG5074070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="391" mass="45444" checksum="4455072A934F6B91" modified="2022-05-25" version="1">MIILGSGGHTTEMFKVLNFLDLDKYYPRVYVHGHSDLMSELKLKSFEIDNDCKVIKIFRSREVGQSYYTSVITTLIAFINAGVIMFREKPDLILANERIDCKLIEIEACLDRTWENLNTGYWKDVSIGHRYCYTICSLLKCILLEIDSREEKNKIQEIAKQIDKGLLLGAPIVEAPELLTNIASKINNYLEETNSYKESLKFEIDDKNIPSNLLEGCEWIKKYKSPSMETFYRDIFKCKVPAVLEECISHWKALTTWKDPNYLIKIGGMRTVPIEIGSSYTQDDWSQQLVTLSEFIKSHVAKKNDTVFGHKQIILYHPEDSKYLYTYDTRLLSNTAQVNPLNPDYNKFPEFKNAKGFMCYLKPGQALYIPPKWWHHVVSLSPSFSISFWWN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H5I2</accession>
    <name>A0A8J2H5I2_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS2053</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001116">
        <property type="protein sequence ID" value="CAG5076072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H5I2"/>
    <dbReference type="OrthoDB" id="7687627at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5076072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="208" mass="23460" checksum="58226CAE20B30AD3" modified="2022-05-25" version="1">MPLNFSLRHAYLEAETDIRSLPMASNIYIITPIQHEQKCAGRSLATLLVSWVAVTMLGAILLRWKHMWIALTVLTLLFLMMCAYAIKMKRQVRPDQRDEQCIIQENINGAAVDNPEIRTRQIQTVSGSVDDFTEIIQPPAYQTFWINDLPPSYSAVIGEQVPPVGPRLALPNDTYATITSNPPPYCAVLRLETDPDNEMSSQNLNSKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H5M6</accession>
    <name>A0A8J2H5M6_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS1178</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001116">
        <property type="protein sequence ID" value="CAG5074967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H5M6"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5074967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="167" mass="18984" checksum="9E4FBB5F80F85535" modified="2022-05-25" version="1">MKLSVLILRINTEIHLEYELNPPISLRVVAKLYFSNKIYPRLIINNSISKIHPDQTSTVSLVFNSGTFSTLFLISKLLSQSELGFPWIPHKLKLQKSARFWSAPRWNGFPCLKCSYLPAFILSLVVIPRTIIWYSWHISSAPTHKECRPVLAAIHITQASQVAAATK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H630</accession>
    <name>A0A8J2H630_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF4218 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS2579</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001117">
        <property type="protein sequence ID" value="CAG5077871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H630"/>
    <dbReference type="OrthoDB" id="6509516at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025452">
        <property type="entry name" value="DUF4218"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004242">
        <property type="entry name" value="Transposase_21"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579">
        <property type="entry name" value="F5/8 TYPE C DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579:SF1">
        <property type="entry name" value="F5_8 TYPE C DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13960">
        <property type="entry name" value="DUF4218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02992">
        <property type="entry name" value="Transposase_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4218" evidence="2">
        <location>
            <begin position="586"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="82"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5077871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="845" mass="97134" checksum="781E181F8518D7FA" modified="2022-05-25" version="1">MAETPPKRYKLYLETTKKRRSKRTTSFPRAVDEYRQKHNTSGPLNIFDVTNSMKSSIVDGKHSISTNVAGVENVSGVEPENRSNSSSNCEETNLHRHNQDTSIDTQTITTEIKNNTFQPKEHTDFLKQSSNGYDRIMFKESETSINDVITMITGFTLRFGLCNNGRTQLMEMFKLCAGSQYNDVSISDHQYNKIFEIPEETIIAHYYCAKCTKIIYISPKKSMKDTEVICDQCVEIIRLNSLNENYFLSINVEYQLKELLKSKNIYSAISESFNNEYSNNSKITDITDSELFVKFANNNEKTIYLNVSTNGTPIFRESKRSMWPLQILVNNLPPRLRFNNVIIAGFMIVTHEPTPELMNLFMESFVKQIENLNSKGFNLADNNTESNQEKINVAVSNFSADSVTQALCQNRVKHSEYFACSYCYIMGETSDGAKHFPFTATIEELRTHDSHIKDVAKCNKKKPKVECRGVEGPSELLSLPNFDMVWSFPFDSMNTWDLGVTKFLWELILKGLNKEETLRLDELVNTIKPPCTVGIFPKAFTDFNNFEAKDFNALLLFYSIPIGFDIFSDDIMYLLALLSKGLFTLSQHEISEDELNECEEMLIIFVDSFQKIFGESKMKLNVHLLLHAVDSVRKSGPLWANYTYLHEGSIHFLKMLVNDAEGVDLQIIEKSINAIKFKSVFHDNNRITNEKVSIYCKNLFSDCKEPLIGTIHNGVLYNESDSVKLNHTSDKKYYDKCVYNKNIYSTMFYDKTNKWDDSYIQLKSGKFARILEIFSSENENLITIEIIDVQQLNINGIVMTHVWKVEAKEIKVVITSLENVLRKVIYIKGENFDFITVQPGNYHND</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H7E2</accession>
    <name>A0A8J2H7E2_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Mitochondrial (Xenopus tropicalis)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HICCMSTLAB_LOCUS3358</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5081706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H7E2"/>
    <dbReference type="OrthoDB" id="185373at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003730">
        <property type="term" value="F:mRNA 3'-UTR binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070129">
        <property type="term" value="P:regulation of mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033490">
        <property type="entry name" value="LRP130"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033443">
        <property type="entry name" value="PROP1-like_PPR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00756">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46669">
        <property type="entry name" value="LEUCINE-RICH PPR MOTIF-CONTAINING PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46669:SF1">
        <property type="entry name" value="LEUCINE-RICH PPR MOTIF-CONTAINING PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01535">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17177">
        <property type="entry name" value="PPR_long"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51375">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="PROP1-like PPR" evidence="3">
        <location>
            <begin position="110"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="169"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="204"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG5081706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="992" mass="114091" checksum="C18698C35E6B4470" modified="2022-05-25" version="1">MRPLSRYIIQMIRNRFRWRCPIYQPHLLVCNNPVHYAQNLSRNYGNSPGPVSTVFNDNLLYQIDIKLQKGNPIPKKLVERLIIELQNFGKIYNFDAFLVIKSCGKSLMDADAKESIELVHYLWDTLESLEVKLEVSHYNALLDVYLEKDYDFSPNKFLSTMIEKSVEPNRVTFQRLIAACCKKGDIAEVMALMVEMKSRNLPLTEENFNMLILGHSQAGDIDSAINTLAIMKDKGIVPSIDTETALMCAYAKQGDFKSLNDSFEKLAANNFDLEERHYMEIFQSLVINGHLEQAENFLSKMPKDLNSDIDTSRLIIKLIKMQHTDLALRLLKSTTANSLRLHARINIFLGSLVKTDTKVEEVIQICERIKKDFANEDPFKEAVYFYLFNGISPSSTLEMMKAWRKVGGQIHDHFFWPLLVLESKASNVDGILNVLKSMIEDFKITPSLRTLRDFTIPYMFGSRKEIINRLKPLNISADTIVIAMADRCIIERQLKNAAILMTFHETKFPTDDEFLHRFVETLNARNDVKSFVVILRLLYSDSGKVSAVCMDKILRKVIDVVPDYRPSVMISLLQELTVAGLSISEEIAGEIRSYLANNVEEVDDVIKKLESGELTEVPMSEYNPYLLQRSEGSGEIIPHSQVYELRNQFNKYVTEFDNERAAAVCKQLDAIGYVTPPFYAMAIGVFCDLGDLETAGKYVEQFSEKLPQHNLSFGKGLKFAELLVKNNRFEEAVRFIKRQPVAKDKQAFSRTNVKAVESLLALTANQESLEKTFQMIDLLADKKLLKAATFPLGIIIESFLEKKEHTKALEVFERAVTEYMCTPNKIKLLETLLLRDDQVNLKRFLEFNNDTWGEKNTDFSMALVNLSIGKYQLVRKYFKNLGSFVSNFQIGFFIDYLEKTENFEALEEFIEITKRLDGNHTNLFKRALKVYVKYDDWEGAMDLWMKMQEDEINPDREFLVTLKKLLVRHQQKVPFVCEDSYKSDREVSGLVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H7I2</accession>
    <name>A0A8J2H7I2_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="3">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HICCMSTLAB_LOCUS3348</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the peptidase C12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="3"/>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5081666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H7I2"/>
    <dbReference type="OrthoDB" id="427186at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.532.10">
        <property type="entry name" value="Peptidase C12, ubiquitin carboxyl-terminal hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001578">
        <property type="entry name" value="Peptidase_C12_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036959">
        <property type="entry name" value="Peptidase_C12_UCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10589">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10589:SF17">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01088">
        <property type="entry name" value="Peptidase_C12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52048">
        <property type="entry name" value="UCH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UCH catalytic" evidence="9">
        <location>
            <begin position="1"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS52048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAG5081666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="127" mass="14312" checksum="778E862B0D3C381E" modified="2022-05-25" version="1">MPIFFRIELEDGILKNFYEEAKDLSFADRGKLLMNTASEIIDAHEQLAQEGQTAAPQENAPVYHHFVAFVAKDGSLWELDGRKSIPINHGPATEDTMLENAAKICGQYMERDPEDLRFTMIALVANE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H7R4</accession>
    <name>A0A8J2H7R4_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similar to Nsun7: Putative methyltransferase NSUN7 (Mus musculus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS3568</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5082458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H7R4"/>
    <dbReference type="OrthoDB" id="10256198at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042620">
        <property type="entry name" value="NSUN7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14663">
        <property type="entry name" value="METHYLTRANSFERASE NSUN7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14663:SF2">
        <property type="entry name" value="METHYLTRANSFERASE NSUN7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="578"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="704"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="759"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="705"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="735"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="766"/>
            <end position="775"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5082458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="874" mass="100359" checksum="250495EE1F807B1E" modified="2022-05-25" version="1">MGVDKSEDEEEENESKEGRRISLFGVYSKVFKVMLSNWKESIEHTEEEDRVSELDELVLPSNEEWRYQVYYRLVDLQREVDSTFDKEISDEDIDVEVKSPVLKDEVFWEWEPIAENPEDLIRNSPDILNENLAKRQEILRRLESPEGSMTEAYMEPGWRLNDILHAAKVLQGESLPQQTSYNDEVEMRRVFGLVYDVLRYKQILNQVLEDVGFWINNRELKKRERIVWLLLFDMQGRKFMSPPQIALTEMRQELFKAAGLMDIEEALLKNKIKIAAGVSRLRIGGSALTLDKLLPAHLRNEGICWTDDEASASGWVNTIKLPTKAEFMAEMTKMGFKLSANWRRLKDNNYAFDPICPKVVILHEKIREQLARSTLVREYRFIFLERSLCFGAASLAKTIRVSHLCGPIILTHLIAPRHTGYLAGLLIDIEDAGRLLAFGAESRRAEYEAYLANLGINEKQCRIFSESYKTAPGFAELERSTVVLATPPCSYTGLTNIVDLIVARGGDTDLLESLTNVDDQAQLERPRKLLAEQMTCLKYILTRPNVQLLIYEAHSTLPSETVEMLQQVVQYANKMAVDKHTREHLPRKRTPTKDSSPKSGGRSSRSGKRPLLQESRTKSSGDEDDEEEISSSPVPQVQVPDSDLFEIGNIFELYGHHNNEQKEVIDNPLAEDGCYLAVVRRKEMMQFNSLFMIKVAESKGLFGNPQASKSPVPEQQSREETSPTSPTPTMPTAIKKLKKGKGKGKKKIVRLDRITAPTHSSMLKVGSRRTSRHSRQSIDNESCESFSVSSVRLSCPRYSERVARDERFISFQVRETRRQDVRRWWEQSATFLIHAARCEPCKFRIFHTDPWTKRVLYAPRVQQIVFPHDDDDLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H836</accession>
    <name>A0A8J2H836_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to Dcaf11: DDB1- and CUL4-associated factor 11 (Rattus norvegicus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS3649</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5082775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H836"/>
    <dbReference type="OrthoDB" id="63070at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080008">
        <property type="term" value="C:Cul4-RING E3 ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000492">
        <property type="entry name" value="LEC14B homolog isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051859">
        <property type="entry name" value="DCAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011659">
        <property type="entry name" value="WD40"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19847">
        <property type="entry name" value="DDB1- AND CUL4-ASSOCIATED FACTOR 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19847:SF7">
        <property type="entry name" value="DDB1- AND CUL4-ASSOCIATED FACTOR 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07676">
        <property type="entry name" value="PD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="256"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="304"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="434"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="473"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="482"/>
            <end position="493"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5082775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="493" mass="55197" checksum="7BCFF144AF27605B" modified="2022-05-25" version="1">MMDLTSRPHMSILRTLQLLIQRGGWDRTGIDDIQRDEASATSSNTLPKIAATPLSTTTLENNEINLSTKRASGFIDPEVERVNNKSVTCMIQKREIGPTFNPGQKCRINNHFLPNRMIPVAKYKSRAFCGSYSSDGKLLVTASQDNLLRIYNTQDGKFHEYKKIFAQNVSWSILDTAFSPDGNYIAYSSWSDALYLCSIYGDSTIQEALPLAPSDLGRFCVFSLVFSCDGKEILGAANDGCLYCYDRECHQPAIKIKGHTDDVNAVAFADNTSQILYSGGDDGLCKVWDRRTLNEANPHPVGVLAGHMDGITFIDPRGDGRYLLTNSKDQSIKLWDVRAFSSKEAEVNTRKAVANQDWDYRWHTHVPKQLYTSTSLLEGDTSIMTYRGHMVVQTLIRCHFSPAATTGQRYIYTGCGHGRIVIYDLLTGNIVRTLEGHEGCVRDVSWHPYHQEIISASWDGVIGCWRYSSQDSCPGTADSEWSDSCDQNWRSPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H8T0</accession>
    <name>A0A8J2H8T0_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS3481</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5082187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H8T0"/>
    <dbReference type="OrthoDB" id="7701454at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="124"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="295"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="492"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="136"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="295"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="308"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="518"/>
            <end position="527"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5082187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="559" mass="63841" checksum="F2C02F712E3B30D3" modified="2022-05-25" version="1">MGQVWCKNKNWKEQDTNKSPLDRVFLRCAQRIYPRFKDDGLNAATQRVSSSEIGYAGSPSTKELLRSRSISSVDRPFQQSDWVDVNLEVTTPKTGNKNKNNNNLTSTNRSLDLSLYQVKTPVPAYKNCKTPPVPPPRKKRRKKIRSLPALKINERASRNNIVKSKKDVEGKEKRREFYEHKVNGTGVIIPSKVVSGWKSAEGLSSHNQKLPEINNTFKVNNISTSSLPNYDQFKLSQLSNAESCKDQLKLSGNKSLESLKYCKYQNSSGRKFTEKTSSRIPVMQNNENLKFLVKGTSSCPNRNSNKYQESRPERKNKENERNYYSLTGDFDKFKQRDVNYLFSPNEITTSRSHPFLNNESTKTDYNSEFRPKLILRRVHSDDNGSLDIMSRSEDFVTKSISEESLPSALMEDDDLNLFEDNTKDPVKNEITKIREELEAVTNEIKTPPRSPQLAKNSTKLRLPEVYADKENINSMTPSLSEFEATLSELLENNTREGVDGKNLGDSNSDSELGRDNNFKSQSQNVSLINIPAPPRRKRRKTLKSNSDDSGFDFYVDRLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H8Y8</accession>
    <name>A0A8J2H8Y8_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS4510</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5087425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H8Y8"/>
    <dbReference type="OrthoDB" id="7699626at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="93"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="253"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="253"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5087425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="510" mass="56993" checksum="ED72C4521A409B32" modified="2022-05-25" version="1">MVRLSITRDRLLCGRQKRCEYINRVIAILPLIIFAFIMKLKADSVPTINGLPPLKLDKNLRRALLRALEDLEAESAEDRSDPPTAEQLVLKIQEQESEEEKTNKDEENKKQEDEELDNKNREKILERFKGASVTYEHFASDSEDISEDKLQNSTFIETDKYQADAQSSEVKAEKSQELNQKLDVLLGDQAVVEKSPEPLQVEQVETRSVKSIGHSSNRIQNSFKPIAKDINHHNHDNDNKEILAISSSNGIASASANSLVPPSPTVSSPTTRPAKNASAPVLPTVPADTKGKNEEKSEVKIFQAPLVAAFTVQQDELGVPKSSFQTNFPDQLRIQQLPLHNDLKQNFNYNQNFNNLNSNLPQQSFLRGQDQRGVNVQSFPSVSVDFQPPAVPSSNRFNRQEALGSVGNFGINENRQQTRNHLVFDLPRPVSSFVPFNQFSSFRQPVHRPPTPARQIQQLLFQSGVAGELGRNHGAPGNHEDLSIVSKVLALNVGAGPNKSLKFNDDFFRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H9D5</accession>
    <name>A0A8J2H9D5_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">UDP-glycosyltransferase group 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HICCMSTLAB_LOCUS4880</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UDP-glycosyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5088519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H9D5"/>
    <dbReference type="OrthoDB" id="5835829at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008194">
        <property type="term" value="F:UDP-glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050271">
        <property type="entry name" value="UDP-glycosyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002213">
        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48043">
        <property type="entry name" value="EG:EG0003.4 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48043:SF46">
        <property type="entry name" value="UDP-GLUCURONOSYLTRANSFERASE UGT-60-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00201">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="430"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAG5088519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="472" mass="53749" checksum="1B55EF2D2F45C56C" modified="2022-05-25" version="1">MFASPPQTALIIGFEDVYDLSLLSNTLSDQGMDVTLIVPSLNSRDIYDHLVQVEVIKINFTLGTDAKKVDKALKACETVLSDKKILDRVREIQPTFTIFPALRHDACLIPLAKSIESIPVIWARGQEEEYYAVEKSRMAIPFQTGTFYERFITNLNLKSIVTYVDNHYVNQAFKLVKQYINNVEDTNLDGLYSDVKVFLWGGDPILRLDFSPLTHQLVEVGCHHCRGVQPLPGVLQKELIEFKQGTVVATLDSEYITMIEHLGQQIPQGQAILWKNKIVKKTNGKNIFIHGDVDRQDIIGYSRTRLLLSHCADTEFLEAAFHGTPLICFPRNSEEKENNLRAVKLGISVTLNNDYTIDNVNKILNEIHENIKYRETARKISLAIRDRLAPASDRLIFSLSYAARHKEIDINYWPIGRDINVNTFSEDINFLYGLIIGIIVGALFVATTALTWYYQSKNSKKFKVIKVKKHSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H9F4</accession>
    <name>A0A8J2H9F4_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similar to GTF3C3: General transcription factor 3C polypeptide 3 (Homo sapiens)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS3753</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5083170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H9F4"/>
    <dbReference type="OrthoDB" id="151490at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000127">
        <property type="term" value="C:transcription factor TFIIIC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006383">
        <property type="term" value="P:transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039340">
        <property type="entry name" value="Tfc4/TFIIIC-102/Sfc4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23082:SF0">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR 3C POLYPEPTIDE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23082">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIIC TFIIIC , POLYPEPTIDE 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="207"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="671"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5083170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="671" mass="77526" checksum="25BF8E17E9B2BDD4" modified="2022-05-25" version="1" fragment="single">TGKKFSKMEELNTKDKTPEIEEIMEPAGEIAPVIIEELSQVDALRVDINEFVEATICHLPADSSNRDEEDNNLVIETGQASDDEDNQTMTPEEEARITRQFLNGEMSFSDFSLLMDRGADGDPQQVAENQNRRLQLPTALKGLMGEANLQYARGHNEVAIRMCMEIIREVPSAPEAYQTLSMIYESEDPEKALHFALIAAHLSPKDCDQWINLANKSLQRRDLRQAITCYLKAIASNPKNVSLYESYAKLQLDYNGDEEAYFKAYKKLLKKLDTEDNEVLVHYAKKLAKMYTEKENYLEAANAMDQIFSKCPSRVTYDDVNIYAEFLIKLKKFRRCLDILISHTGIGVKYSDDERKIIESCCLPDDTPIDLKVRFIVTMLELGFTKQVLGHMDALLAYEEAEKFGDLFLDIVDGLMHVQEYARALKFLELLIRCKNYSMPAVWLRYAECHVGCRQLKEAILAYEIKYCLSFGRPLQDTVLTFHESKTPPTDQQEWMIFLKACHVAYKLKKFGVLQRICFTGLTSKKFESQIRDLTWLCLLSCIYNNDSFNGHNIIRELVRDTHEQNLWNLLNIVVQKADDTRHNRFIMRLLGRVDVQSYLHILQANNCLVSGTYKYALNDYFPEPPHDKIIKENLELLDIRREAAFNIHLIYLQTGNKELARMYLHEFIVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H9V2</accession>
    <name>A0A8J2H9V2_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">tRNA:m(4)X modification enzyme TRM13</fullName>
            <ecNumber evidence="12">2.1.1.225</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">HICCMSTLAB_LOCUS3585</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="12">tRNA methylase which 2'-O-methylates cytidine(4) in tRNA(Pro) and tRNA(Gly)(GCC), and adenosine(4) in tRNA(His).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11 12">
            <text>adenosine(4) in tRNA(His) + S-adenosyl-L-methionine = 2'-O-methyladenosine(4) in tRNA(His) + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:43196"/>
            <dbReference type="Rhea" id="RHEA-COMP:10401"/>
            <dbReference type="Rhea" id="RHEA-COMP:10402"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74477"/>
            <dbReference type="EC" id="2.1.1.225"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 12">
            <text>cytidine(4) in tRNA(Gly)(GCC) + S-adenosyl-L-methionine = 2'-O-methylcytidine(4) in tRNA(Gly)(GCC) + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:43192"/>
            <dbReference type="Rhea" id="RHEA-COMP:10399"/>
            <dbReference type="Rhea" id="RHEA-COMP:10400"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74495"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="EC" id="2.1.1.225"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 12">
            <text>cytidine(4) in tRNA(Pro) + S-adenosyl-L-methionine = 2'-O-methylcytidine(4) in tRNA(Pro) + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:32767"/>
            <dbReference type="Rhea" id="RHEA-COMP:10397"/>
            <dbReference type="Rhea" id="RHEA-COMP:10398"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74495"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="EC" id="2.1.1.225"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 12">Belongs to the methyltransferase TRM13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.225" evidence="12"/>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5082522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H9V2"/>
    <dbReference type="OrthoDB" id="258806at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106050">
        <property type="term" value="F:tRNA 2'-O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007871">
        <property type="entry name" value="Methyltransferase_TRM13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039044">
        <property type="entry name" value="Trm13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022776">
        <property type="entry name" value="TRM13/UPF0224_CHHC_Znf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021721">
        <property type="entry name" value="Znf_CCCH-type_TRM13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12998">
        <property type="entry name" value="TRNA:M(4)X MODIFICATION ENZYME TRM13 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12998:SF0">
        <property type="entry name" value="TRNA:M(4)X MODIFICATION ENZYME TRM13 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05206">
        <property type="entry name" value="TRM13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11722">
        <property type="entry name" value="zf-TRM13_CCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05253">
        <property type="entry name" value="zf-U11-48K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51800">
        <property type="entry name" value="ZF_CHHC_U11_48K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 12" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 12" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="8 12" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CHHC U11-48K-type" evidence="13">
        <location>
            <begin position="43"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU367103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CAG5082522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="388" mass="44121" checksum="ECDB812A684B7303" modified="2022-05-25" version="1">MNSDHCKFFVERKKRFCRMTVKKGNEYCGEHMEKNVTEKTSKRIPCPLDDSHTCFESKLKQHLKVCNAKRLLDARPDCIVDGINSGDVDLQAPERIPLTLLDQSVIENVIKKVEAAAEKLSEVEELILQHSILDAEVNNSSYGNYLKKHLIQNSSLLAHLNRAGLLRENTCFIEFGAGKGQLIKNTKESTVILVDRSSHRHKNDNKLKTEDCSINIVRIRADIADLCLNKIKEVKSSKYTVGIAKHLCGAATDLTLRCLTNSTEDTEVSGLIIAFCCHHRCEYISYVGKKYLQECGFTPEEFPILCSIASWATCGYDKNRQASVTEKELSDEKRRETRESIGRKVKSLLNWGRIKYLESMGFDSKLYYYTYPEISLENMCVVATRKNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HA71</accession>
    <name>A0A8J2HA71_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to TMEM68: Transmembrane protein 68 (Bos taurus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS4572</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5087669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HA71"/>
    <dbReference type="OrthoDB" id="44277at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07987">
        <property type="entry name" value="LPLAT_MGAT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22753:SF14">
        <property type="entry name" value="MONOACYLGLYCEROL_DIACYLGLYCEROL O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22753">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 68"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="domain" description="Phospholipid/glycerol acyltransferase" evidence="2">
        <location>
            <begin position="65"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5087669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="287" mass="32941" checksum="013AEC8FB284BC8B" modified="2022-05-25" version="1">MPLLITFLLPIIILLLLYMTAAIFYIYKLHRGRLQEAYGRDWKSAARSVVAAIWDVHGYIYYGYEVVGMENIPTDEPVLFVYYHGAVPIDLYYLIAKMVLLRSKIIHTVADNFLFKVPGFAIICDVMKLIPGTVQTCSQILQEGNMLAIAPGGVYEAQFGDSYYKLMWKNRMGFAKVAVESKVKVIPFFTRNLREAFRTVSWGRRLWLRIYSLTRFPFAPIYGGFPVKLVTYIGKPIDYQEGLSPDQIKLKVAEALEQLINQHQSVPGSITRALLERVYNPTRHKKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HAU5</accession>
    <name>A0A8J2HAU5_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Peptidase M1 membrane alanine aminopeptidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS4363</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5085395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HAU5"/>
    <dbReference type="OrthoDB" id="10031169at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="entry name" value="Neutral Protease Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014782">
        <property type="entry name" value="Peptidase_M1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01433">
        <property type="entry name" value="Peptidase_M1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M1 membrane alanine aminopeptidase" evidence="1">
        <location>
            <begin position="62"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5085395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="154" mass="17910" checksum="05C405A4A3189616" modified="2022-05-25" version="1">MEFRRKFNCVVKYAGNINRESDGIDKILTYFEVSPRLSPHSIEIVSEKINFPEPKSELALYQYKKTEAIILAEALSLQWFGNLVTQIWWDDLWLLAYGISNFLAAEIIDQIFENETIKKPKIGYLLTHTNHIPRFNKTAVHQSALPVQEKLKNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HAX6</accession>
    <name>A0A8J2HAX6_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Similar to Gastrula zinc finger protein XlCGF46.1 (Xenopus laevis)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HICCMSTLAB_LOCUS4438</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5087175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HAX6"/>
    <dbReference type="OrthoDB" id="10072647at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001269">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000340">
        <property type="entry name" value="zinc finger protein 473 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000145">
        <property type="entry name" value="Zinc finger protein 574"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050752">
        <property type="entry name" value="C2H2-ZF_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24384">
        <property type="entry name" value="FINGER PUTATIVE TRANSCRIPTION FACTOR FAMILY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24384:SF218">
        <property type="entry name" value="ZINC FINGER PROTEIN 502"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="366"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="394"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="422"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="450"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="806"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="834"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="862"/>
            <end position="889"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="315"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="470"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="655"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="765"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="900"/>
            <end position="929"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="332"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="483"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="668"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="773"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="903"/>
            <end position="922"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAG5087175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="929" mass="101848" checksum="355B66F106FE2BC3" modified="2022-05-25" version="1">MTTPLLLSHHVTLLRDGILNKTPVLSDSSKMNFTPFPGFTTGSLPTGAVHQFTTKFAQNITAGGQVVGVLSGGEGGVHYLRPVDPNGFTVATQGGNNQQQQIITLPITVPGKDGTQQQQTVQIQVVNPTVTQGGNSADQPKYHIAPISLSQFPQGAATVLTVAYIVTSTAQQTIQQAVQLPNTPEGLTVVAQIPQDLILREAIDSKDDIKEGTTPVALIKRANVKNQGNQSGDEYITSMPATWQSLAAPGSAVADYLSRLPTSTLPLNLHHFLKFSAETIKRESTIESSPLGADGLEAGSAGAGDQTVQITVASGETEIIPDVPEEQESGTKPKRKKKYKKKPPKPKKPKPGQVSIVTALDGTTLFCCPQCNMAYPEKELLEQHLIGHKIERRFICDICGAGLKRKEHLERHKLGHNPDRPFICSVCMKGFKRKEHLNLHFVIHSGQKTEVCTECGKAFYRKDHLRKHARSHLAKRAKEDPLNTGDNTQTQQQNEQSPQNQQVDMQQQTTLPELQQIQIQVGQGSQAQIHQIAVSEQSTVRESNQSGVENYYIYSPAVDSGIFGVGTSSIGRRRVSHFPATIPSIHQFTADGTSGSTARYANHFPNQPPIGVPVVGKYRSEINGSQTGQSQGMISNKTAYSNSNVHSHYANVPYSQAQSEKKSEEQQRNTGDSASTNDSGQQDYSSIHQHHQQHAHTQTPASMPATWQSLATPGSTVADYLSHLPASTLPLSLHHFLKYSAESIKKESEMQAHTTSVAVATTTTPNIMMSPTTKKKKKKKVPKEKKPRPKPGEIRLTTALDGSTLYCCPECHMAYPERELLEQHLLGHTLERRFVCDICGAGLKRKDHLTRHKQSHNPERPYVCTVCLKAFKRKEQLTLHFVIHSGEKRHVCTECGKDYQQPSDAPSSSSRGSQCRGSSSSCRRPRCYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HBF5</accession>
    <name>A0A8J2HBF5_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similar to CG7065: Uncharacterized protein CG7065 (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS6270</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5092638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5877502at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="307"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="517"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="776"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="895"/>
            <end position="938"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="995"/>
            <end position="1072"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1085"/>
            <end position="1124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1153"/>
            <end position="1195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1200"/>
            <end position="1219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1226"/>
            <end position="1312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="307"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="349"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="371"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="407"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="429"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="517"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="585"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="895"/>
            <end position="911"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="912"/>
            <end position="925"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1003"/>
            <end position="1015"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1032"/>
            <end position="1046"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1053"/>
            <end position="1067"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1100"/>
            <end position="1112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1114"/>
            <end position="1124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1172"/>
            <end position="1183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1201"/>
            <end position="1219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1235"/>
            <end position="1248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1255"/>
            <end position="1282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1298"/>
            <end position="1312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5092638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="1312" mass="149902" checksum="C206256192FB3C92" modified="2022-05-25" version="1">MQNFDDLDIEGRNPSYLSEEEREKDENDRKRLMRCSVTAEDSTLRPVYSQMEEGDIWCHICNLQLFGAHKLQSHNNSSRHKLKLDEWPYPVSLWSDKDTIKKLQGPLSGTIGIPNSLAPGEPVPPGMEDQITRTTTIQMSLDRHQSSPLVGLEYLLELVDNDSCEPSYTCVLCDKRGDPRTVMAHITSYNHRISYLNRHFPTISRAIGDLPRTLNYKRGANEMSVLVAKKIEEKFGRLQPQLVDKAQFEKNRVQFIKNILLFFDVYKLKVAVSYVRRETPELTFMEVYDVRWVTNFEEKLAEMTADKKDVSKEVDKKEKSKKEDRIMEKAFPKKIEPDTSKSSMKIRIVTKEKLMKKPSKDNVRPSDDTKSLSSLSSISSSPSPSRSRSRSPGNPRFNPSNHSKSSSSKHRSYSSKSRHHPRGSRSRSHSIEPHRERDKWEKYRELIRRTEENLNRALTFHEKNPEKHPCYPDEWKKFWNRRYKELQAEGKDPSKHDFKPEWIEFWNKRMRELHNEQLSSRKEDIRKQLDLPEDKPPEQPIKWSSSTKRNSKEDRLPSPPPPVAKKTRLPDSDDDDVEYVGTKTIKPEPKVRTAGEYREQRERERERERERERDRHHEHAREMVRERDYSYLYARDKPPYRPYYQATPRPVIHPRVRHYAPYPLKEKSASPPAQNLEALKEDLEIIGLLRLLSAIEQQLGSMGPKVVELLKRALALEKAKPNSAEELLLDEEVSVFFEAVKEKLKGQLFAGMIEKKAIPATKSAVQNIAQLLHKAEEDKKKKEEEEEKRKKQTEEIARSLASFSRSAFLTRSSDVSSMKSEPVSVPGVGAVDKVAIAQQIAAALVAQGRTNVSQDELETLINAVVGMAEASQHSDKPITAASFVKSLTATEAPAAPALTPTPVTPVAQVAPAPAPPPPPPPPPGPVEEKKPELAPVETVETHAARMENLTDNDLKDLLQNFNDLGTDKQHGLINFLKKLEASDPARVEKLRGYVNLGSSGGSVRDDSPRDDEPISKGRSPSPFASRKGAHNPSDDDHLKWKPKIDMFADDEEDRRRKDDERPKKIDLSDDDDDYTFEDIYKAADKNVLESQKAKRHSDSVARSWSRSRSRSPLSRKEKSNDTILSETKRLIDNIMGGLPNKYVVKSHMQRERSPVNSDILPPGSTNVTIPPQNYPPFNPPNQSLPPVHQPAQLHQPSHQVNYNLPNQQNPYPQNYSQQNYPNSAYMTNNVQPMSNMNNGYNQPYNQPYSGNNMAPNQNQYGPPQNQYPQSQPQSQQMYGGPPNQYGSGPSAPGPIGYPQQNTNQYGNYNRFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HBR9</accession>
    <name>A0A8J2HBR9_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Similar to SLC17A5: Sialin (Homo sapiens)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HICCMSTLAB_LOCUS4364</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5085399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HBR9"/>
    <dbReference type="OrthoDB" id="2250022at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015291">
        <property type="term" value="F:secondary active transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006820">
        <property type="term" value="P:monoatomic anion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17380">
        <property type="entry name" value="MFS_SLC17A9_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000452">
        <property type="entry name" value="sialin-like isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050382">
        <property type="entry name" value="MFS_Na/Anion_cotransporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044777">
        <property type="entry name" value="SLC17A9-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11662:SF40">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11662">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="49"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="79"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="103"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="138"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="162"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="300"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="346"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="379"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="13"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAG5085399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="407" mass="44818" checksum="E999B602A6945096" modified="2022-05-25" version="1">MARFRMLPRTSRIVALCSAANFINAADRVIMPIAIVQMTDEYKWNLHWQGWILSAFAFGYFTSQIIGANTASKFGCKTVLMSAVLLWSISTLITPLLVDSIPLLITCRVILGLGEGLGLPVIFHLFAHSVPVEERSRAFGYLVAAGSVGQVVASILCPRIPWQTGFYFFGTIGIFWTLLWLILYHESNPQDHEIPLFVPKVNQNRPIRWTELICHWPLWSLYIAHFAMNWSNYIIMQWLPTYLSRNLSANKESISLTALPYIVNSLVGIAAGHSADNLVQKRWPILSVRRLMTNIGLMGPGIFMLAFCAVDNLLLAVIFISISMGLCACNSAGHLSNHAEVAPNHAGMTFAISNTIATIPGILCGPVTAELVTASSGRWMPVFVLAAAINFTGAIIYQTHSSALPVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HBX9</accession>
    <name>A0A8J2HBX9_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Lipid droplet-associated hydrolase</fullName>
            <ecNumber evidence="9">3.1.1.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Lipid droplet-associated serine hydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HICCMSTLAB_LOCUS4428</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a cholesterol ester + H2O = cholesterol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:36403"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16113"/>
            <dbReference type="ChEBI" id="CHEBI:17002"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="EC" id="3.1.1.13"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:36404"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Lipid droplet</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the AB hydrolase superfamily. LDAH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.13" evidence="9"/>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5087135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HBX9"/>
    <dbReference type="OrthoDB" id="448051at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004771">
        <property type="term" value="F:sterol ester esterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034389">
        <property type="term" value="P:lipid droplet organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019915">
        <property type="term" value="P:lipid storage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000068">
        <property type="entry name" value="Lipid droplet associated hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019363">
        <property type="entry name" value="LDAH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13390">
        <property type="entry name" value="LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13390:SF0">
        <property type="entry name" value="LIPID DROPLET-ASSOCIATED HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10230">
        <property type="entry name" value="LIDHydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0551">Lipid droplet</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00039150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAG5087135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="312" mass="35300" checksum="9BF8A3841BDEFA76" modified="2022-05-25" version="1">MQQAMLLCNGVQTHVMTEGRWVEEGLSQTGSKDLVIVIPGNPGIPSFYSGFIKSLKSRLPSETPVWTVGHAGHVQPPKNLCFMSEDDSDKPVYTLQDQLEHKVAFIKQYVPKDAKLHLVGHSIGSWCILQLLKDPEIAKQVVRCYLLFPTIERMAETPNGKFLTNFVLRAATLIVFLAWIFSFFPVVLQSILIRIFGGFFAGVTNKSIKPVRQLLEPPVLDRVFKLAQDEMVKVRERDDELISNYEDKLWVYYGATDGWTPQNYCTELKAKHPDINAQICKRGFRHAFVLTDEVEVGKMVGDIISETMSNNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HCJ5</accession>
    <name>A0A8J2HCJ5_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">deoxyhypusine monooxygenase</fullName>
            <ecNumber evidence="4">1.14.99.29</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HICCMSTLAB_LOCUS4966</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[eIF5A protein]-deoxyhypusine + AH2 + O2 = [eIF5A protein]-hypusine + A + H2O</text>
            <dbReference type="Rhea" id="RHEA:14101"/>
            <dbReference type="Rhea" id="RHEA-COMP:10144"/>
            <dbReference type="Rhea" id="RHEA-COMP:12592"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:82657"/>
            <dbReference type="ChEBI" id="CHEBI:91175"/>
            <dbReference type="EC" id="1.14.99.29"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; eIF5A hypusination.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.99.29" evidence="4"/>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5088748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HCJ5"/>
    <dbReference type="OrthoDB" id="421002at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019135">
        <property type="term" value="F:deoxyhypusine monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000099">
        <property type="entry name" value="Deoxyhypusine hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004155">
        <property type="entry name" value="PBS_lyase_HEAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12697:SF5">
        <property type="entry name" value="DEOXYHYPUSINE HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12697">
        <property type="entry name" value="PBS LYASE HEAT-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13646">
        <property type="entry name" value="HEAT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00567">
        <property type="entry name" value="EZ_HEAT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0386">Hypusine biosynthesis</keyword>
    <keyword evidence="8" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAG5088748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="202" mass="22708" checksum="28FBFD04227FCAC7" modified="2022-05-25" version="1">MSIDEEKIRGIGKVLNDETRPLKERFRALFSLKNIGGQLAIESIEQGFKDPSALLKHELAYCLGQMQDPRANPVLINVLKDVNQEPMVRHEAGEALGAIGDESVIPILEEYSKDPVIEVAETCQLALNRLKWWKNAEKSSDKSSENPYASVDPAPPLPVKDVEELKSILLNEELSLFDRYRAMFSLRNLRSKESVLALSEGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HDA9</accession>
    <name>A0A8J2HDA9_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to FBL4: F-box/LRR-repeat protein 4 (Arabidopsis thaliana)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS7504</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5095028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HDA9"/>
    <dbReference type="OrthoDB" id="27842at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031146">
        <property type="term" value="P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057207">
        <property type="entry name" value="FBXL15_LRR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006553">
        <property type="entry name" value="Leu-rich_rpt_Cys-con_subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13318:SF95">
        <property type="entry name" value="F-BOX PROTEIN YLR352W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13318">
        <property type="entry name" value="PARTNER OF PAIRED, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25372">
        <property type="entry name" value="DUF7885"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00367">
        <property type="entry name" value="LRR_CC"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="10"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5095028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="712" mass="80636" checksum="95D2F2A648D15AD7" modified="2022-05-25" version="1">MALEDAEDWVDEAAHLPIEVIMHIMSYLSVSDRMAAGLVCREWHEASLSTKFIDKQAVIISREDDNMHLVMNTLLKSQRPFHHFIFKEVEIKKNLPIWDKFGGIIRSLILVCCDLSERTLVSILKCCENLRTLHINACRECLMSGRLLDDKKDVKELSDNFQSLLELSLASNRYLSDALFNRLVSICPNLQSLSLTDCQISFHSGVYKRFYPHNSIEQASESLLTFFNVLMYVKRQAKRLKHVSFGSTLIDSTALSSLASVEGLKLESLKLRSCDQLTNVGLRSLTRQISLKVLDISFCTRVTDQSLICICQNLFNLESLNVRRCRAITDYGVTQIRLLKKLKELDISECEQLTGACITQGLSLQSIDKNELTFTADNQDLENLNADKLDAHNYNDTDESIKDENYPSVLSSSDNCLQTLSANALNLDEKSIECIANSFPKLTFLDIGYCFSAVNDKTIQKVFKELTLLRTLRISRCDKVSDAGLTGMGAGNRINNADSKIEKIIPELTDSRLKIRLGSRAEEEIVRDAYRKREVMEMCEDTTSPCELDIFSGFSLIRLKGLRELDFTGCNKVTDVSLKHAFTFPELRVLDLSMCQQITHVGLDYLTKNNQAIEDLNLSQCHNVTDIGILYIAQRLYRLKRLQIRGCSQLTDHSLAGIKSYCKNLQYLDASYCRGITMSGIESLCSHLHVKFSEQLDSLSSRDVPVPPLIRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HDN2</accession>
    <name>A0A8J2HDN2_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Similar to Pheta1: Sesquipedalian-1 (Rattus norvegicus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HICCMSTLAB_LOCUS6264</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5092632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2157866at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00136">
        <property type="entry name" value="PDZ_canonical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47644">
        <property type="entry name" value="AGAP008221-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47644:SF1">
        <property type="entry name" value="PDZ DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDZ" evidence="3">
        <location>
            <begin position="1447"/>
            <end position="1525"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="2">
        <location>
            <begin position="1542"/>
            <end position="1644"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="2">
        <location>
            <begin position="1669"/>
            <end position="1774"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="353"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="708"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="867"/>
            <end position="902"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="921"/>
            <end position="941"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="969"/>
            <end position="1121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1233"/>
            <end position="1282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1321"/>
            <end position="1371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="365"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="742"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="759"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="779"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="874"/>
            <end position="884"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1013"/>
            <end position="1023"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1039"/>
            <end position="1051"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1052"/>
            <end position="1066"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1249"/>
            <end position="1262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG5092632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="1780" mass="198810" checksum="B2299B57A5CE21DC" modified="2022-05-25" version="1">MAGVSSAAIRTPMGRARIYRGAGSPASEIAMDPRSLQDSFNSSSNTSSGVYLSSNPQVDVSTQVDLNSAMIHDWDRRATPLYSREDFKEQYCITSRQLDAVEKSSGGIFGCLSAKGLSPCTATRVSILSACVRSASSDENLCDAPYPRKPFQIFYQQPYPSYHRGITRYDLDDDEWVNTSYFRRRPTSFCTIADPKRYTWLQEDEESMRLEGPRSVLTAINQPHGIHKPKHVSFARSHTLTSFEIASRSKSPPRPHAQERLIDTQPTAQACPPAGMIHPYPPPEPKILILEKNKRGVMKTQATQTELPTGLRREPPVTLSPRTIHRVKMVSQGAQTNGIINGRKLTKSYSEAGQFGAPLGTNGTNKEEPVEHEPLQRTQSEEPPKSPFLIDSPPKSPARDQLGNGSLVNGDLELTGKRLSKEEEEILIDFKPAPVSPDARAMLKQMPLVWRRPITLQKTFSDGEIQIERRELIDEAGAPSYPHTCRRNYNDPWSRNIRPPVQFSSTPDDLSLLRTQSPQDDNHEEVTKFFIPIQSILCHANSSMLCSNKFQEFHENIIRRGLFRKRSVSLEDGVQDLASSDFNLPRSLPTSPTSPTAIPRIRKVEETPRYEIRRPSFLRTCPIVGPITSPFASSDSLNNDVTKDHSDGIWNESQATVLQADTLALLTPSSRRRHLLLLQHQQRSSMDTETLDVEDDIEICPPSPRILLEPPLIVHTPSEPLLTNGRPRSGLRRRSPGPPYSLPQSQSSSELALSIGRTDSGRTDTTDRSEASTTEDYVTANTSTGTGTTTGTSATISSWSRPSGYHASSSAAASAPASTTATAADGSSFESASSIYSLARSEAVLEELPPSPQAIFEEIEMPFDLADLVPPSPARSSSSSSSGSYDLEDAMPDPCPEFTMAPLSGHASEAELDHDYNRASERRLSSGYVESPPEPHTWTDEPRRRSFVLEFPTGLEDHSHHSDRAELLLDPDVSPTPSHRHRPRTKVNAGRSPYRNNKKRDPQSPISALSRSPQKEEWNREIGDDPVQIPTSDDSSCSHHYHMHHHHHHVHRDNMERHRRTRESPRRKTSGYVSTRRRSNEDKNAAFTGSLPRRRSRPIEDCSNRLSPGSRYRSPGHNGHTTVIVKSPSCLETRLKALSAESLRSVSPGSDSVFYSESADLCAAHHDTSHCHSCGKEVGSLFKDNPKNSTNHNRFQVTEEIVQPPAGFADSPEGPRIIAKHSGHRLYKKLDKRYRSEDRGERRYHRNNGRSDVRAKSEERGSRPSSRGSIEDGIRRRLQARSTDVSMETLAYREDEDTYIEPYTGNEWIYIGELEESHVWKRPDSRDGDDESSEGPIKDRRGSQGSTQSEKDFRKKYQTATHRMVHRKSSGEMYKRMQSKSFVFVPANPQIDKMVCDAAGGYPAELGEDVSLKSSLEELLKCMLRVWCREGQALTKLGAPEPESDKTVIVKREAGGEFGFRIHGSKPVVVSAIEPDTPAESSGLEVGDIIMSVNGRSVMDATHSEVVRLAHSGPDVLELEVARTCNVLAPRVARSPKESGDVAVYSGYLWRRATTVNPAGIATDKWVRRWFALRRDNCLYYYKTDSDAQPVGAVMLLKYDVEATPELRNFSFAIRKLGAPSHHLAADSEEMMQNWITVIKEAVERNNQADTWLDASVRMQQLPACSIQRPDCFGYLSKQQDRAKKTSSPTGWSRRYCVLKDAALYFYDDANAEKAFGVACLHGFKVHGSASHGGGRKHAFELQPPDPTQRSYTFATETEMDKKRWLAALEYSIDRWIKVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HET1</accession>
    <name>A0A8J2HET1_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Similar to LPP: Lipoma-preferred partner homolog (Gallus gallus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">HICCMSTLAB_LOCUS6370</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell junction</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the zyxin/ajuba family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5092787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HET1"/>
    <dbReference type="OrthoDB" id="25414at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005925">
        <property type="term" value="C:focal adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001725">
        <property type="term" value="C:stress fiber"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098609">
        <property type="term" value="P:cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09351">
        <property type="entry name" value="LIM1_LPP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09354">
        <property type="entry name" value="LIM2_LPP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09437">
        <property type="entry name" value="LIM3_LPP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000109">
        <property type="entry name" value="Lipoma preferred partner"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000027">
        <property type="entry name" value="lipoma-preferred partner isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000042">
        <property type="entry name" value="lipoma-preferred partner isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24207">
        <property type="entry name" value="ZYX102 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24207:SF2">
        <property type="entry name" value="ZYX102 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00478">
        <property type="entry name" value="LIM_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="9" id="KW-0965">Cell junction</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10 11" id="KW-0440">LIM domain</keyword>
    <keyword evidence="5 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="7 11" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="LIM zinc-binding" evidence="13">
        <location>
            <begin position="401"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="domain" description="LIM zinc-binding" evidence="13">
        <location>
            <begin position="461"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="domain" description="LIM zinc-binding" evidence="13">
        <location>
            <begin position="522"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="42"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="244"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="61"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="271"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="292"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="310"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CAG5092787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="600" mass="66866" checksum="1AE7D84E4C658547" modified="2022-05-25" version="1">MMSNVKNLEQQIASLQIDNANNSKEISSTSGIAGTVKQVKKIGPAVPPKPKKSQPQVPQSYTIKSPSTPSYSTVLNNTQMNEKINNYYANTPLPYVPPNTEKNVFTSGLSSQPPSTSQPLITTNSARADARNYYNNENFYQNDHLYSNEIENFNGKRTDVNKVNNSITLNPRYDDKNYYLNIGGNIPAPQAPVMVDNRSIRATRNVVYSNVEPAVPIPVPTPINSIKEKDIIYSNIQWNKPENTYSNITNARDDLPPPPEPTEYISCVPGSFPPPPEELPPPPSPVSSSYSELRRATYDPHHQTDYPPDHHHHHHHHHHHDYPNDIYGPSSQSSSTYESIYEPINPRPPSQLSCNYSMYSGYGSASTQPPGKVSPVKEVDTLTDLLVQGMEDNQDDSDIYGICAHCGKKVEGEGTGCSAMDKVFHIDCFCCFVCRVNLQGKPFYSLEGKPYCEEDYLNTLEKCCVCTRPILDRILRATGKPYHPSCFTCVVCGQSLDGIPFTVDATNQIHCIQCFHKKFAPRCCVCKLPIMPEPGQDETVRVVALDRSFHIQCYKCEDCGLRLSSDAEGSGCYPLDDHVLCKSCNAKRVQALTSHMTTEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HEX8</accession>
    <name>A0A8J2HEX8_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Similar to Dlg5: Disks large homolog 5 (Mus musculus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HICCMSTLAB_LOCUS8474</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5096965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10067129at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035331">
        <property type="term" value="P:negative regulation of hippo signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06767">
        <property type="entry name" value="PDZ3_DLG5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11860">
        <property type="entry name" value="SH3_DLG5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035537">
        <property type="entry name" value="DLG5_SH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053004">
        <property type="entry name" value="MAGUK_Signaling_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46360">
        <property type="entry name" value="DISKS LARGE HOMOLOG 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46360:SF1">
        <property type="entry name" value="DISKS LARGE HOMOLOG 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="PDZ" evidence="6">
        <location>
            <begin position="538"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="6">
        <location>
            <begin position="636"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="6">
        <location>
            <begin position="1256"/>
            <end position="1335"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="6">
        <location>
            <begin position="1505"/>
            <end position="1585"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="5">
        <location>
            <begin position="1596"/>
            <end position="1666"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="363"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="803"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="972"/>
            <end position="1033"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1047"/>
            <end position="1106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1177"/>
            <end position="1209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1355"/>
            <end position="1434"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1478"/>
            <end position="1500"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1678"/>
            <end position="1706"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="106"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="229"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="483"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="363"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="804"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="985"/>
            <end position="1004"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1020"/>
            <end position="1033"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1047"/>
            <end position="1063"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="1073"/>
            <end position="1083"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1180"/>
            <end position="1199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1356"/>
            <end position="1366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1386"/>
            <end position="1405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1478"/>
            <end position="1498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="1690"/>
            <end position="1700"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAG5096965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="1805" mass="203518" checksum="CCEF8CBE5F7C9048" modified="2022-05-25" version="1">MASGTSSLDSAGSSDGVFNIERDSGGYGSVGSPVGGPECRSDYDGLQAQCDQAMHELQFLRHKHSDTVRRNEHTMKELEYYRGQHIAAMNQLEATSQETSALRGKYSDLINDKQRLDREVQALQKEVTELRCQNQECLVVDSGNSDAINQHYLSVLRKYEALKDEYDALRKRHDDLLSAHSSLKNKFELIEKEAARWKKDHDDVIQERNNAFRERNGLKQQCTAAIRQWDIALRERNEYREALAKLQQQHEEAVKEVNQGMVLRIKASKDLKRLTEERNSTLQEYRLIMGERDTVHKEMEKLGDDLTKAYEKIAKLENQNKQHVDEKKTLSYQIETLRQEISSALFDRDKYLQQCEDLKHKFGDYSEDSSRDYNNRLEIHSHNRERDNSNKEIERETSTRNYAKREKEQMDNLDQANLELDKLRKAVDTLQAELEEALQEAEVSKRRRDWAFSERDKIVLERESMRTTCETLRAERDQAVTALAIALRDSDDIKKQRNEASRELKDLKEKIENGDHSLRSSQYHDDDGMAEWDILSIPIDFGRVCQDERDLGFVLAGGREDPNYPNDTGVYVAKVTNGSVVDGKLKVDDCIIRVNNVDCSTESTRRILENLRDFAVESSVTLTVRRRRTTRRSLRTIQLPIGSVPHGISLELGIYIAKISPGSLAATDGNLAAGDRVLNINSKPMEGVTSTHEAMSILNDTSVDVLTITTLKGIALSSILSTETIDSSFGSDKQKMVNSCSQTEQERMKVMLKATSDDYERRYIASNFGDRSIYKVSKSVSSEKSSGISNAWGNFREKIDIVTGRRHSKDRDDKKKRHRNSSPNTFEQEQDAIAELDSVIESYHKKTNNGVFKRSKRRGTEKIEKIEKNGGTWPKARGGPLIQNGTGTILQPRKTKERLPLSVLLNHPPKYESFNYNRTSNPVPLSTFSNVSNRHTVYKAVEYPISNLSKSGQLFGQKSFSPAVQFKDMSLDSKKPSTEFETTENRLSSSHAPSETSMDFSVKSTGREPDYGHAKRRTQKPYTSGSHENQSDALQHNRVHSQLYPLVTTSGSSSSVPKQQLAGNFSFPPYAHSHPHPHPHPHPHQQNSLPSRYPSPPSLPSAQSGEFIGLPDVRSFCFEPPYSPGQPGFGHLHTPSVDLHYHKSRGHPAGIPYDLPGYTHGYEGGTFPRKKENQRFRIPSNPSVTSKSSVGKLSTGSIERTSERGSPMPTFHVEVLSPGIGGTNGGRAVRGSFNVKRASMPDYFTQPRPAPGELRRVHIDKSVEPLGIQISCLDSGGVFVSTVNEHSLASQVGLQIGDQLLEVCGINMRSATYELAAHVLRQCGNSITMLVQYSPDSEYLQVLWERIKFQKYNELEGSGSSSSSEAGGEEGASRSGSPTPCNSPEALRKTTLETLEPNKLEREKINTLMPPSREREVRSSASMEVRGTQEREREIRQSASLDINIRKPELRNSATIDSLRSAGNTLTRSQINQAVTTLQRQNATVRSPTQEEQNQKSPPTIEPRYLFIETRKCSNLGISLVGGNGVGIFVHSVQPGCLAEDAGLRTGDRILEYNGVDLRQATAEQAALELARPADKVTLVAQFMPERYNEVKDKPGDSFYVKAMFDRVGEVGDSLQLRFKKDDILYVDNTMFNGTPGHWRAWLVDKAGRRQQCGIIPSKFKIEEELLLRRSLGDLETDTGRRGTTSARRSFFRRKKHHRSSSRDSKELSQLTGVNLGWYSDSGTLNEENVPASYQRVERLDYPTLRPVLIIGPLNECVTTKLLQEFPGEFIRCIPEAMHCSQATLEQGIRDFQYVDYRKKGSYFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HFK4</accession>
    <name>A0A8J2HFK4_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Similar to myoM: Myosin-M heavy chain (Dictyostelium discoideum)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HICCMSTLAB_LOCUS8860</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5097753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2015333at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031097">
        <property type="term" value="C:medial cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035025">
        <property type="term" value="P:positive regulation of Rho protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00160">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.900.10:FF:000038">
        <property type="entry name" value="Myosin-M heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051480">
        <property type="entry name" value="Endocytic_GEF_Adapter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46006:SF5">
        <property type="entry name" value="DH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46006">
        <property type="entry name" value="RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR AT 64C, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DH" evidence="5">
        <location>
            <begin position="1117"/>
            <end position="1312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="295"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="415"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="541"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="738"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1023"/>
            <end position="1070"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="441"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="42"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="64"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="88"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="300"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="541"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="554"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1023"/>
            <end position="1034"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1035"/>
            <end position="1049"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1060"/>
            <end position="1069"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAG5097753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="1458" mass="164488" checksum="53771704AFAD2752" modified="2022-05-25" version="1">MRRSRLVEPRSRARSISPYRQSNQRDQRSQSVMRGTKERKTSTTSTTGVSRTEWFDTEVNYTDEFPRKSPTDDWCKENSADSNTPLITAQTSTSTSASSPSTSSSTSRQSKGKNKWQEPLRANITSQAEDVTLTSTIDSRKSILECNVNPYLLVKKNLTTKDEDDLSDDLSDNALELDDMSSSLFDPSKVKSIERLPNRGAVAAIGGQRIRVFNEPRELISDEDNTVSSIQPVTRIPIPKVSPKRPPRRPKEVKAVLKSILKRGKGTLAPNSDGVRKNVLFNVNNIIFAPEKSNDRRISKSSLLSNNNNNNNNNNNNNSINKNISKEDDLEKPIVPEEVKERPKFITIPNIKEPKRQEKFQECKIIPEVKTMFQDRKVNNNNSNNKRPEVPMRNKKVGDDKTMTVEGNIDVYGKKNGRTEREQDGGAPKMAEPKIERGEDETNLEIEIEELKDRLTDIETEEKDLLLKADDQSPRLCLTRSQSDRSIAKPDVSAAGIQYLDTMRLSLRRPSSKDLLEVEESLPASSPPLIPSITITTVEKLTSHEEKEARPSKLTESPPSYRSMNFNPSIEQFKRMRPTSWSPPPGKHKHGFRERVSDPGPFNHIIVMPESPKSPQFQTWSPSCSKIEIGSKAEVNVCKITVSPKSAPLVHRLQVGGEFPKGSKRTSILINGESSEAEPNITDNKVTISVGGEDSVCNPTVISVNSTSPPKIQSSKENRTLVILDNYQSNIVLESAKAKSRERDASADKMADKKPKMEDKDAQSQIFVRDEKRWSGLSKESLISKLLEDSLRKARENGEILDESSGEAILRILKQSLLKTKEYESSESTLEAEQFSRSPSMNSDVDFSTNLFLEENPYEVIKEPIYEEIPDEPPPLPLSPPPTEDYIKGRIYFPEEYKESYYKKVNAGQYLGSYLTEDVFKKDEGDYLSKSPQEFFKPTGDGKLTKKFELLNFLMDKDRVVEVEDEVEIEDDEDEDTEGDLEALYEQKETSMGDLSSKSSQISNVSDSSEECNIILTSSAEATKTRSVDIERTDSGVGSESSQASSSRGVVRRWRAGNTSSSSSSGPGSLLAGIPQVISGDAKLCEDCEQRLEPLITDSGVVYAPFVCRKCSKKRAERKEIITEIVETEQKYGRDLRIILEEFHRPMLRAGLLTQEQLSAIFLNVEELLEHNLLLAEKLKDAVELSQVSGDEDLVTVDVGKIFLESERMLHAFESYCTRQGGASCLLQNLEKEKELLRIFLKVSQMENTVLRRMNLNSFLMVPVQRVTKYPLLLARLLKATPSVRIDVLEARKRLEQARANIELHLEHMNAEAKDVTSTKLWRRISIIQNGRRSNGEHDMVNIKLRKMAVEVLEWAHEEARFVLEGRLLVAQPTDNNWRRGRTVKLAPVIAMLVTNGKSNTEFVDLNDDSLFPRQIGIKEATLLLKMVQEQKDGVEHSKRMRSHWAPGEDVEELFRTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HFU3</accession>
    <name>A0A8J2HFU3_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">palmitoyl-protein hydrolase</fullName>
            <ecNumber evidence="2">3.1.2.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HICCMSTLAB_LOCUS7338</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>S-hexadecanoyl-L-cysteinyl-[protein] + H2O = L-cysteinyl-[protein] + hexadecanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19233"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:7896"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="3.1.2.22"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Endomembrane system</location>
            <topology evidence="9">Lipid-anchor</topology>
            <orientation evidence="9">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the AB hydrolase superfamily. ABHD17 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.2.22" evidence="2"/>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5094012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HFU3"/>
    <dbReference type="OrthoDB" id="446723at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008474">
        <property type="term" value="F:palmitoyl-(protein) hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000008">
        <property type="entry name" value="Alpha/beta hydrolase domain-containing protein 17B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12277">
        <property type="entry name" value="ALPHA/BETA HYDROLASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12277:SF81">
        <property type="entry name" value="PROTEIN ABHD13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0564">Palmitate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="357"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="630"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="685"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="359"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="402"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="414"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="702"/>
            <end position="711"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00046278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAG5094012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="777" mass="85900" checksum="7530EC4070A225F1" modified="2022-05-25" version="1">MNSLGEFCSLFCCPPCPSRIVAKLAFAPPEPTYSFLEDEGSKFTISLSKRAEWHYTEREKESIEGFYARTSRGNRIACLFVRCSATARFTILFSHGNAVDLGQMSSFYLGLGSRINCNIFSYDYSGYGVSGGKPSEKNLYADIDAAWHALRTRYGISPENIILYGQSIGTVPTVDLAARYEVGAVILHSPLMSGMRVAFPNTKRTWFFDAFLSIDKVPKVMSPVLVIHGTEDDVINISHGLAIYERCPKAVEPLWVEPVEDEQTNLDKEEHDKSISNYLNTISRAMLLCDDEPSPESSDEVFFFCEEQANNLNINNKCDDSKDSKDNNKIINNSYSKSSSIDQSVTKADNQVVIINNKQKGRKNPNLFNRKRNNKKSPDNQDFSKANYSLKEVNPDDNQNLSEVSESISTSTTDLANASERQNEATQTSQPVMVKIHVENCSQCPDNLISQEASPVAGKDNLCKVKKKTVAVQVNFNSIVNNSVADSHCVKISKVRCCNKATQRVQSLNWGNKCNDIGDNDINSWSGKNMKNQSTNAGSGVITGDNKVKLHDKSNSVDRASIKSKKFSNAVSPLKQFNRSSLTIGPDKITVNQNLNCYNNIRPIPSYSNNLSKYSPCASRLAASSKILGNTSPTALSPESPLHGARPKSPRFGDSLSLSDSNSPKARLPQEKMTLQASLSLNINQLKKPHSTPRSRSVGDSCVTSPTSEATTLRYSPTGTEILSLDEIARQKQQIKIQKHHHRSNSVSLSAPDLKALHTDRLSMPIDIRKANLETKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HFV7</accession>
    <name>A0A8J2HFV7_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">[RNA-polymerase]-subunit kinase</fullName>
            <ecNumber evidence="2">2.7.11.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HICCMSTLAB_LOCUS9401</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.23" evidence="2"/>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5100134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HFV7"/>
    <dbReference type="OrthoDB" id="1732493at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070985">
        <property type="term" value="C:transcription factor TFIIK complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004693">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008353">
        <property type="term" value="F:RNA polymerase II CTD heptapeptide repeat kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF0">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 8 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="8"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="38"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAG5100134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="230" mass="26235" checksum="68B06A93692A7FE8" modified="2022-05-25" version="1">MAEKLRRYEKIDFLGEGQFATVYKAKDTETDQIVAVKKHDNIIGLLDVFGYKSNVSLVFDFMDTDLEIIIKDSSIVFTISHIKSYMIQTLQGLDYLHCNWILHRDLKPNNLLVNQKGILKIEETWPGMTELTDFIQFKPFIGIPFSDIFTAVGADLLDLISSLLRINPSERCTCSQALQMPFFSNKPAPTPGDKLPLPISVRRLKENRPSLKRKLLENIDGGTLAKRLQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HGP4</accession>
    <name>A0A8J2HGP4_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similar to NOF: 120.7 kDa protein in NOF-FB transposable element (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS8368</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5096753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HGP4"/>
    <dbReference type="OrthoDB" id="7600614at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5096753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="1079" mass="124342" checksum="80B1BB8F3F711597" modified="2022-05-25" version="1" fragment="single">MWNFHSGDDNNDKSDEFGSSVSDNDDECEDFHVIITREQWNLMRRDKPFVYKNRKYYGFEPGVWTNVVSLAFWEQYRLKCAFVFKRGKINESGINYAVISGRCKDCSCRNFVRGIIKDPPSDKGPVVITMKCRDTRFSKHTDLKRPLNGIRRKEVQQKLLRSGVLGWRKEEAKNILKPGDTGSPFLYNSGTLQEARKEATDKEIGIHPDDRRDMILAIRKMNQDPQNMNSILWISDTPFFVFYATPTQFHTYAEYLRIHKQYSSISIDATGGLVKKLMDSRDKKTGHIFLYQVVINFDEKVNLPRQAVSDGSRALLNAMSIAFNGKSLKDYINFVFESLITNANQQPRTFIRLDTAHFLHAVSRWKCFQSALHKVVKSFFLYCTALMIDCDELSKLEEIFMMTSIVCSTEFDDSIIAMGDRMITPEEARKNLEELVAKRQPDITIIDSLEVDPDKTVIFDELPSKATDNKGWSVALIIWIDSLCKKVNTIIFVGQKLNTHYVPGLYTDLVDKMKDFSLWTNVCTPKTMSRPNSCYVETDFKNLKMNLGGVNIFRSKLTKLVADNCCNENEKKPKEENLYENWKGFGKNETATDYDWVSDYRDFSDMVEQNDLDSVLENPIDMAINRNSARNKNDSMTTFKTYDDHNYSSTSFQEQDKNSNINTSIHNSEIDNSSDAELSSKYNNMQNDSVISVENHNDLTYYRNFYGDKNHCLNISISDVENSISLDTRLIDTVSEIVTITCTDTIDNSIHNLSLTKLLDNEKKIYKDLTLKQNSLQEPLSLAIENMMKQKTLNKKHGHYFQGCPEAALLNNLVDEKKSTSTKKSKNFLLRNGNKTGPVQFGRSKWTALNTCPFDTIIQIIFTVAIDNTHYRDFISKSNLQTFKFLKNFMINGATQKIYEHRMAILNPIYNTKKLEDDMKIKVAPYINCHDNIIKLWKVLFEDVPSVIETTVCSNSLCQTYMQAFPVISVNHKIITRHGFTALEKAIEFNHKIYNVHCRFCCKAIATRTTVPKQYLLIELDVRDNKCGRKGKKCKLSELPIHLHLKLNDDKFKTNLHYRLSGVAAFSTGHYFAYCRRLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HH21</accession>
    <name>A0A8J2HH21_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Endonuclease/exonuclease/phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS9913</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5100840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HH21"/>
    <dbReference type="OrthoDB" id="7701337at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14529">
        <property type="entry name" value="Exo_endo_phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="2">
        <location>
            <begin position="115"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="428"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5100840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="544" mass="63761" checksum="FCAF470B34C09436" modified="2022-05-25" version="1">MARVGGKSTYHIAFWNVAGVRNKEEDFWVGIREWDVVVLIETWVNRKKWTEIRESWKKGFKWQIQEAKLPKGRGRAKGGILVGVKEGIEIRNKGKWDEEGWAEVEVLLGGEWWWIIGVYINGDMGRKKELMSKWMDEAGDERILFGGDFNARTASEGGLRTVDDQLGRSVRRSKDNVYNKDGKELCSFLEEKGWAIVNGCVKGDEEGEWTFVGERGCSVIDLVLIDERSRDRIMELRIEERTDSDHLTIVVKVEVQGKRSREGYKERINRTGRGVWTQEGRSNFQEEFGNAGVQVGNLDEDWRRLKERIRGAIRESEKTRVKSRGVSSWWDEECREGKGKLRRSLQSFRKKKIPKEEYFLEKKTYKKLCEEKKRLEKQRWEDWVKSARTEGQVWKVVNEGRKKRSGINKDIPMETWDLYFREVLGGSERKVTREGSMIEEELDEMEEDEISLDEVREMIARTGIRTQNLPKTCRLLYHLSYPVYTKFPILNIRSLSGPYRSYPVYTKHPTIDMKSSVPLEWAKDFILTLPSLYTSTCKRCDFEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HHA6</accession>
    <name>A0A8J2HHA6_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">MH2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS8779</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5097591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HHA6"/>
    <dbReference type="OrthoDB" id="5973987at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009791">
        <property type="term" value="P:post-embryonic development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050793">
        <property type="term" value="P:regulation of developmental process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051239">
        <property type="term" value="P:regulation of multicellular organismal process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.200.10:FF:000006">
        <property type="entry name" value="Expansion, isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017855">
        <property type="entry name" value="SMAD-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001132">
        <property type="entry name" value="SMAD_dom_Dwarfin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22742">
        <property type="entry name" value="EXPANSION, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22742:SF2">
        <property type="entry name" value="EXPANSION, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03166">
        <property type="entry name" value="MH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00524">
        <property type="entry name" value="DWB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51076">
        <property type="entry name" value="MH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MH2" evidence="2">
        <location>
            <begin position="55"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="285"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5097591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="475" mass="54419" checksum="9C93B877326891E5" modified="2022-05-25" version="1">MVSRRKILSRSRDNLADSQYDDQEEEDVWYNLDKLYKDHIQEVLDKWNQIDDEIWAKVIVFERNRRVAKAYARAPVLTVNDSIDGFDGFRIGLCGFDNPMRDPKTEETKRHIDLGVKIKMDDKGNILIKRLCKSNVYIKTTHPEENAVGAEILRNSQGALEFEKPGKLFDMAKYEQNLERETRRSYPDRRRLEKQCLSAIVFVRTEAELLKCPVWVLIVNVVGLELLKSKLPILPALKRSVDIKNRPRIPIPDEDPYSVAGVAAASGPSELRDAVRDPRHEQIYGQSAAYHRRRTEKPPKLPPRENLYGQNIPKPDYDDIEDDYGSNGVRPAVVVTEDSKKNNKKNDRKNDDPYYCGMRARVPNFVKMAKNSQIRILPAYGTGTGRPQPAPAQTQISAPAYIGYNSSQSQSSHIYASHAPNRRPPIMYHARSFESGLDSDDRIDSPYNHIYGRLPIPTRSFIPPVPRGMYIGEWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HHE9</accession>
    <name>A0A8J2HHE9_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Similar to Nca: Neurocalcin homolog (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HICCMSTLAB_LOCUS8306</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the recoverin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5096631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HHE9"/>
    <dbReference type="OrthoDB" id="191686at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000072">
        <property type="entry name" value="Hippocalcin-like protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028846">
        <property type="entry name" value="Recoverin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23055">
        <property type="entry name" value="CALCIUM BINDING PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23055:SF178">
        <property type="entry name" value="NEUROCALCIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00450">
        <property type="entry name" value="RECOVERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="6" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0519">Myristate</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="7">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="7">
        <location>
            <begin position="38"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG5096631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="86" mass="9804" checksum="EE688506801A535D" modified="2022-05-25" version="1">MYDLDGNGYISRQEMLEIVTAIYKMVGTVMKMPEDESTPEKRTDKIFRQMDKNKDGKLSLEEFIEGAKSDPSIVRLLQCDPSAQAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HHT7</accession>
    <name>A0A8J2HHT7_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS9141</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5099601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HHT7"/>
    <dbReference type="OrthoDB" id="6703982at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5099601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="183" mass="20495" checksum="ECDB32E0655C8B1F" modified="2022-05-25" version="1">MNYGLNEPDPCLPLILPPRYRLRDLILGDYAFNDDGESKERGSCPDICIIGAVAEPATAPHYCESNGTECSLFNHRRPRDPLGGSNASSEPLLEMSTMGWEYEPLSDIPTPIGDVTPSSSPPKETLQKVHSAPRVCFEPDNLEATRRRSSSRLTSIRRRSRSMSAWGDLSRCSFRLDERFSNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HHW7</accession>
    <name>A0A8J2HHW7_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Proteasomal ubiquitin receptor ADRM1 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HICCMSTLAB_LOCUS10655</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="7">May function as a proteasomal ubiquitin receptor. May promote the deubiquitinating activity associated with the 26S proteasome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ADRM1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5101754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HHW7"/>
    <dbReference type="OrthoDB" id="340431at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008541">
        <property type="term" value="C:proteasome regulatory particle, lid subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061133">
        <property type="term" value="F:endopeptidase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070628">
        <property type="term" value="F:proteasome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13314">
        <property type="entry name" value="PH_Rpn13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.70:FF:000001">
        <property type="entry name" value="Proteasomal ubiquitin receptor ADRM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.2020.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.70">
        <property type="entry name" value="Proteasomal ubiquitin receptor Rpn13/ADRM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044867">
        <property type="entry name" value="DEUBAD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006773">
        <property type="entry name" value="Rpn13/ADRM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044868">
        <property type="entry name" value="Rpn13/ADRM1_Pru"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038633">
        <property type="entry name" value="Rpn13/ADRM1_Pru_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032368">
        <property type="entry name" value="RPN13_DEUBAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038108">
        <property type="entry name" value="RPN13_DEUBAD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12225">
        <property type="entry name" value="ADHESION REGULATING MOLECULE 1 110 KDA CELL MEMBRANE GLYCOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12225:SF0">
        <property type="entry name" value="PROTEASOMAL UBIQUITIN RECEPTOR ADRM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04683">
        <property type="entry name" value="Rpn13_ADRM1_Pru"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16550">
        <property type="entry name" value="RPN13_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51916">
        <property type="entry name" value="DEUBAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51917">
        <property type="entry name" value="PRU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0647">Proteasome</keyword>
    <keyword evidence="12" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pru" evidence="11">
        <location>
            <begin position="14"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="DEUBAD" evidence="10">
        <location>
            <begin position="279"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="121"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="170"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="388"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="123"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="182"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="396"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="410"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00054744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00070663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAG5101754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="433" mass="46956" checksum="792E019A2B55A5EE" modified="2022-05-25" version="1">MASGALFSNNTVRGASKNLVELKAGKMTIKGKTVYPDTRKGLLYVYQSDDSLMHLCWKDRTSGVIEDDLIIFPEDCEFKHVPDCKTGRVYLLKFKLSNKKFFFWLQDIKTEKDEEHCKKINDVLNNPPTPGSQRSGGTNPEGDLQNLLNNMSQQQLMQLFGGVGQMGLGNLLGTMRERPHSSRTTTSSTPVTTSATRPPAAQTPAPTTVTPSETPRSSSGTTKTSGSKPASSSSTNLLDRTPATLMSDPHLFDLQRHLWNFPSPQVNQALWGKKTGGSPAGIICCSRSATAELIVRQTDVETELTNSIPAAITSSESLERTMSKHLPSGDNLCTTLSSPQFSQALSMFWSALQSGQGAPMVRQFGLGPDTVNAAATGNLEEFVTALETETKKDQEQTSSTTVASSNPEDESTKKDDSSSAKKDDSKDDEMALD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HHZ2</accession>
    <name>A0A8J2HHZ2_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS9586</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5100502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HHZ2"/>
    <dbReference type="OrthoDB" id="6076990at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5100502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="112" mass="12285" checksum="5CC69C49BDB7E6DA" modified="2022-05-25" version="1">MSSNSEFSTMSSGEVPSLPKSLPSSREATAEGNSSSAGGFIPLRDFLDRFSLPRVVRLEGTGGRPVLLYKQQQRSLRVTATLLIHRYRHDVKVGPEIVIPEGYPDQIKSGKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HI10</accession>
    <name>A0A8J2HI10_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Similar to Piezo: Piezo-type mechanosensitive ion channel component (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">HICCMSTLAB_LOCUS8069</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PIEZO (TC 1.A.75) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5096157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="303066at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008381">
        <property type="term" value="F:mechanosensitive monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027272">
        <property type="entry name" value="Piezo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031334">
        <property type="entry name" value="Piezo_cap_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056770">
        <property type="entry name" value="Piezo_THU9_anchor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056769">
        <property type="entry name" value="Piezo_TM1-24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031805">
        <property type="entry name" value="Piezo_TM25-28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056768">
        <property type="entry name" value="THU_Piezo"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47049">
        <property type="entry name" value="PIEZO-TYPE MECHANOSENSITIVE ION CHANNEL HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47049:SF2">
        <property type="entry name" value="PIEZO-TYPE MECHANOSENSITIVE ION CHANNEL HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12166">
        <property type="entry name" value="Piezo_cap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24874">
        <property type="entry name" value="Piezo_THU9_anchor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24871">
        <property type="entry name" value="Piezo_TM1-24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15917">
        <property type="entry name" value="Piezo_TM25-28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23188">
        <property type="entry name" value="THU_Piezo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0407">Ion channel</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="24"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="58"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="118"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="175"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="203"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="227"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="296"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="387"/>
            <end position="409"/>
        </location>
    </feature>
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    <feature type="transmembrane region" description="Helical" evidence="11">
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            <begin position="2020"/>
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    </evidence>
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    </evidence>
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            <dbReference type="Pfam" id="PF12166"/>
        </source>
    </evidence>
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            <dbReference type="Pfam" id="PF15917"/>
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    </evidence>
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            <dbReference type="Pfam" id="PF23188"/>
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    </evidence>
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            <dbReference type="Pfam" id="PF24871"/>
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    </evidence>
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            <dbReference type="Pfam" id="PF24874"/>
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    </evidence>
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            <dbReference type="EMBL" id="CAG5096157.1"/>
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    </evidence>
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            <dbReference type="Proteomes" id="UP000786811"/>
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    </evidence>
    <sequence length="2784" mass="320231" checksum="7D1742827D2A9017" modified="2022-05-25" version="1">MGQYWLNVAILRIAVPGTFTACTIWRPTALSLIYLILMLISPFIPIPTSETMKRTTGYYLKSCIALTFIISVIQFIFQIILVASPSIWTKFTENCSFLEELFRHFGLVRMDGASTLEVFYWLLPEILTLPIMVTLYILCRRFTSKNNHQDLESTPVQDQNLQSSLRNAEERNAKIINFLGRIGTYIVLASLCYTATLSPSVEGGFYFLVFFGAGTWWACNRELVRNFAIICRVVMVVVVGHIVVLMSYQNQWPQEYIPVDSRWSRYFALEAYYKTNCTDPRNTIFTLDNDDWTQNGYAYALRLFWLYYILALQSKFLFQSPTPTTATSASPPDEKTPLMRFGSGRAGLLQDSTGSVTVQDGHNDDNIQMQSIVEDTQEDNLGVIEQVIMAIYSILQLFVHSSYLATNIIMMTWSIMYHSWTTFVFLLWALIIWMAPNKRSAMMKCSPFVVMYGTILLLICYVYSMNLTPEERPDQIIGGVPMSEVGFPNANELKSWHLMVKCGFMVMFWITMRQYMSERHQARQTSALRDMIAPLRVSVSAATAMHQETPEIKSKFMKDVGLVVKKLLTKFWIVVVAIMLFTSGITGERMTMFRIMYMTLFLFFVISFQISWVAWRKMMYGFWITVIAYSVIMLILVYTYQFRDFTSYWEHLGINERLQNDIGLEVYKTKDLFVRLLTPTFFVIITVIQIHYFHDDFLEATDIDKIQVLPELQRADSEATTVPPTSTLDVLLGSDQEASTIFTLRQLKHMSKLERAAFFRRTVKQLINFYNYLWLILEIHIQKIVFTSLILLCINDVCAINLIFVTAIVIIINFRRPIQIMGINSMSVVIALLMVTKMLYQIQYIDPDKFNVNCTRENPDNGNQTLKIYNIAEWIGLKKAPAAWGDTSDSNANKIPPTNDKPSEQEMLAYLLKGYIGIVIVTTLRAIITVRQSFYRRWRGEPLEVPEVMFPKIKRAEADKGIAECLKFFLNYGFYKFGLEFCLIGIVILIRARIDFYSVVYGVWLLVFFAQSRRVTAKIWPFFRVFAIILLPLQYFFVVAPPTWLCINYPWVNIYRRLQEWMYLPDPDDPPNPRKLICDFFLLYMIVRQSLVFNIEANCSANNTEHPAGHNYSVFRDMDKPNFVNPVKDYVSFIHNWLDVIKRGVMMSFMWITLSMMFLAGTNRTNIFSLGYLIGSFIFLWQGSDFYLRPLRVILRWWNFLIGYNVVIIFLKVLFQGFGCILITQFQKSACWLVQLLGIACYQNRNSQFKIDVSDDIKCQMPQDDSGLMWDGFCFAFLIIQKRLFKSYYFFHIVDETKAMSILASRGAELLENLHRKRIEFQESVENTILQNIKLKMDKIKADQQKIHGPSWQEPAHHKVGMAPLARTCSASSYVSSGHTPPQGYQTPIDDSDTDNSSEDLQDDKQQYDPPPLTPRASSLLQAPSPNSAIVSVSLEGYLEPTRISFGSPPSSELNPRGVSPDETFPVFSPPPYDQPANSDRSCQSLLKIIHRRRQSSLAGTNWNPEAPTISGHSVISITSRSQRSHHTYSLYPRDRPLYKHRAPKTNREAVRSGDYYMFDDVDDEDVTEALPDSEMEIDEEEQRRLQRHKGRRMTVSELMSTLFKTDIEIATHVAMYGGTSKDALRLRRQSMPLSRKKSSMSYLSARSETETAATTDEVDRSSEISGEAQARRKSRKNSQKSPSRSGENADDKDSSATSLEDDEAKKRVSFLTYFKFLFELINSFMISATRHLNKFSRDYRYIRKVLSKEKLILKAKPDFRMGMRLGINQIWQPIPLMKDSIARKLVCKFARPDRSETEASSKETVAIEDPDQLEAKSERKESLLTVPHIRILAPSLERGLDGSSSSSMLTRTQPISQMEEEEPQLSEVDQPTIIQLLASIWFGILAHSTFMCYFMIFLHQINNASVLSVPLPLMVFFWGSLTIPRPSKTFWVTIIAYTEAIVIIKCIFQWDLIAWNQVSGRNPLATTTIIGVDRKTNYALWDLLLLLMVFFHRFMLKSIGQWTTPYATRKIIPSKLVIGPDGPSPASGPSQAGSTRLQWQNEKQTHQSNQELNSVSTSKDLPKAAGTSDETNSDYHNNTDSDEERLVEIRNEETNVCDAKLTTAVSMTFKKYLEPTKGFFANILNPDGKEKTNVYAYMFLCDFFNFLLIIFRFSSFGNQQGDGGVTAYLQENRVPMPFLIMMLIQFALIVIDRALYLRKSILGKLAFQYALIVGIHIWMFFFLPGITGRAFNDSLPPQIWYIIKCFYLLLAAYQLRLGYPTRILGNFLCKKYNIVNYCLFKGFMLIPFLFELRAVMDWIWTDTSMTVMDWFKMEDIFASIYQIKCMRGLESDFPQPRGEKKKQMSKYLVGGGLLLVIIGLIWFPLLLFALSSTVGVSNIPSEVSLRIQISSHEPIYTAIAQDASIFSYTDEEFKALKGIYTSDRPAYTFLDNYGSGDVATVKLSKSTQRIWGITPLEKEQLKNELKSNITMNIHVEWAVSRKTDAKDFPGISTTPNIIPLPAYVNGEFNPIRTNLSLLLSSDSDNPNVTLSLPHVFPKFLKITSRNTSVVEQLMHAPTQIYMQDEIITNSPDNLYRNVTLQLVSELGQQWWMIQEQCNDNLYNKVLKNVPLNDCSNNIVMFMFNEKAFPEGLSFFSGMGILGLYTTAVIVVSQLMRRIVSDMAPKIMFDDMPYVDRILKLCLDIYLVRESKELSLEEDLFAKLIFLYRSPETLIRWTRPPESNQDDDRDDNEDFDEPDDNNRRNNNDDDDDDDVNVDVDVNDDVNDNGPQVRQRTNERRSDEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HIS7</accession>
    <name>A0A8J2HIS7_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS8584</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5097191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HIS7"/>
    <dbReference type="OrthoDB" id="6616542at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035240268" evidence="1">
        <location>
            <begin position="21"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5097191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="252" mass="27914" checksum="DB54BCC94EBB117D" modified="2022-05-25" version="1" fragment="single">MFGKLLVLLLVANVDKHVLSKPTSTTETVELTLETPKEIINSTIIKVPNRWDRSMELLGQIMDSLRFGRGRFVNFVMMARNEIAERAEEFTSEAANKLVSLLAARDARKIIQNKTEKRNAISPRSEIVTTVSTPIKIGPLDSFLPAKTRETSRLESETGQSLFEFKKPKPVQGFLENLLSPVPLVDRIKEEDKYGNTGDKFIGIGRALINGFEGFSNFLNTIVDLPVDAAKKTSRGITAALNQIGGKLVGLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HIV9</accession>
    <name>A0A8J2HIV9_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Exocyst complex component 8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HICCMSTLAB_LOCUS11149</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell projection</location>
            <location evidence="3">Growth cone</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Perinuclear region</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the EXO84 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5102718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HIV9"/>
    <dbReference type="OrthoDB" id="642193at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000145">
        <property type="term" value="C:exocyst"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030426">
        <property type="term" value="C:growth cone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006893">
        <property type="term" value="P:Golgi to plasma membrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01226">
        <property type="entry name" value="PH_RalBD_exo84"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1220">
        <property type="entry name" value="Exo84p, C-terminal helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1210">
        <property type="entry name" value="Exo84p, N-terminal helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016159">
        <property type="entry name" value="Cullin_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033961">
        <property type="entry name" value="Exo84"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032403">
        <property type="entry name" value="Exo84_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042561">
        <property type="entry name" value="Exo84_C_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042560">
        <property type="entry name" value="Exo84_C_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21426">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21426:SF12">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16528">
        <property type="entry name" value="Exo84_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08700">
        <property type="entry name" value="VPS51_Exo84_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74788">
        <property type="entry name" value="Cullin repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PH" evidence="9">
        <location>
            <begin position="147"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAG5102718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="699" mass="79551" checksum="868E17A6012E83F9" modified="2022-05-25" version="1">MTEELMTRFANDDFNPDKFVKDLSTQCIGATELHKQRIKIQELNDKTSIQLKRNVYQNYMQFIETAKEISHLESEMYQLSQLLSEQRSLLSALNSNRSTGAIFDDILKNHQDFNVVSKEQEQKQKLIQLLEHVEGGMSLVDTPGRICFHEGSLLELDPLEGTPLKRVHGYLFNDILMIASWLSTSGRRQPSKYKVQAVYNLQCLAVVNVKDLGSVKLAFKLLAFPDTRVFQCASAISKKEWLEKCEQAKKIRLLQECPLEPTNKQETQKEFTMLTSRSMSLDSHSLGVEEGDDSADSLEPLPEWLSEVTEDLDSCIAQRHFEEAYNLFEKAMSYLKATQTSQSIEIKKKIENRGKCLVEVLTDELELSIEAKSLQGGGLRSARRAVKLLIQLNRSAQACKIYLQLCNAALTSRLKRVKREGTVVPYVKQLSAIAFSNIFDMAKEFLKLFSPSMNCTSSLIVWCSQEVKYLTSHLIKQLFIPQVTLGTLVECIHTVRSHCDQLTYLGIDLRYQLDGQLRTHLARALQDSSEKYIDAIKVRAAEDNWRPLNFQTSENLQKLQSELDDLGIPIPSAFITSDCWISLTSNTLAFSKLYIGLLDDCLSIYTPELLCTIETVLISVLRAQVQYILVALNNPKLKSEKKLVQDNTAYIREIIIQRGLELYRSIVGQEFTELIELKKAIIMDLTSEKSKLTPKTLKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HJW6</accession>
    <name>A0A8J2HJW6_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS10111</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5101038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HJW6"/>
    <dbReference type="OrthoDB" id="2102561at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="22"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5101038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="127" mass="13940" checksum="E7F8517732DEEB24" modified="2022-05-25" version="1">MPAKKVTEEPDDSQTWELLERCLLPVAFSHAVAVIISTVLNTLGISQTSSFVLFLLFLSLSIGFTLFYHNLKVTAPGKAVLVTGCDSRVGCALAKRLDELGFTVFAGFTNKIMGINTCKRLDYSRLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HJY1</accession>
    <name>A0A8J2HJY1_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS9490</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5100311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HJY1"/>
    <dbReference type="OrthoDB" id="5914531at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001784">
        <property type="term" value="F:phosphotyrosine residue binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051846">
        <property type="entry name" value="SH2_domain_adapters"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15127">
        <property type="entry name" value="HEAVYWEIGHT, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15127:SF32">
        <property type="entry name" value="HEAVYWEIGHT, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0727">SH2 domain</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="97"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="240"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="307"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="385"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="497"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="552"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="632"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="12"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="24"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="97"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="134"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="255"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="310"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="553"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="634"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="664"/>
            <end position="682"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5100311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="886" mass="98483" checksum="6D650DC0D0C8177A" modified="2022-05-25" version="1">MYGLWSLFDPSASDSSTNENFTGRPHRRKSKSHSRASTIGKESSSNREKSETNDGVTVDCVALVHVPDHSPTDSNQPVRHPSPYYYGDLFKTLDQQSKSQLNQYRKSVSLDVPAEKSRTPALPKRNSVAGDGASSSLSSNLQPQQPQPQQQPSQDLVSSAESEHALQSKSNEILSSCIITEWDHTLMPPHRLLSHDLPTTVCLCVASPDEDELETPVKVARHQVRKLRRTRRIEPQQPVLVENEYDGETEKPGDEADGEEEAADVEEVEDEEMARQRHLYETAFDCKVNRSDDDLDDVDRVTNHPVLHSQMRTSLSTVKSRASSSTEASKLNQNVHYVTVPQQLASKEHRRKVVLLRPKPIPNRLHNPPDNMSSLSQDIESLQINSGDEKSSSPRNPAREYTPSPPSTAPLPVKFRGNKDHLLLNIRSAPNLPSQPDHPRLKDIRLPVKSLRAKESPQSSEGCIIEIKSRPKSLIQDNNESNSCRTDKELILEFKGRPKEERQRPRSLIRESRPIMEFKGRPHEAEGDLPRPKRELGLIEFKLRQARRRIGYSSTESMATSSSGGSMESLRSSTSEGNRSTSSSESRHSTSLSSHSSDSGSTNCFHHHHHNHHQPVSGFLTYHAPKLHILSPISDKSSQEPVSETSDNNRNNNSQKASPEEATTENVPVNTNTNTNTNTNTNAITNTLNVVSPTDTSFKKRRAPQNKNLINLAMQSSSSGDAEIQGSDSGISIESRAGIKCKPFGFHVIKSQMDNINLVDNEPDLSDLPFDMPKLRRRRLLMQQDATTSGSATSVDLRDLPFDMPKLRRRLRCTQSTESSGSQASSSLSVRDVDSLTVIVLLCNMQAPIRTPANVALGFDGTLNTSRLSDEYRGGPNCECSNVNIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HK74</accession>
    <name>A0A8J2HK74_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS9704</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5100631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HK74"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5100631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="89" mass="10157" checksum="D27B7488E653C917" modified="2022-05-25" version="1">MQPSRQYATLRLLSKARMLNFGSRNFSKSTGPNRFKFAGNLSLMELFRISFSSFKSDKSFKSHMRVTHTHSPYVMSPINAGIVGKLLRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HKN5</accession>
    <name>A0A8J2HKN5_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to NOF: 120.7 kDa protein in NOF-FB transposable element (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS9678</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5100605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HKN5"/>
    <dbReference type="OrthoDB" id="7700560at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057560">
        <property type="entry name" value="Znf_SCAND3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23663">
        <property type="entry name" value="Znf_SCAND3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SCAN" evidence="2">
        <location>
            <begin position="641"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="384"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="544"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="384"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="546"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="576"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5100605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="800" mass="91854" checksum="945F700578DFCACC" modified="2022-05-25" version="1" fragment="single">MAPGVWEDMISDKLIETAKITCGLSFNYHTITWDESSGTFRGYCQCGSILYGIINNEDTKKQVEFTCTITKGSGKCGKRWLRGKKREDTVAEMGEKTVNVYRAEKAEEKMEHGEQEPPNLPSSPVLRTARYEERKKKFLHTDPIQALQILKYTDGKFIIRNIGFDPFYVHYWSRHQLNIFRDYHAREPSCLGIDATGKIMKKLVKYGEIKSKSIYLYHGVIRLNEGQFPVLQMISESQNTNSIHFWLNEWIRSGAPSPSEVVIDGGRAIITGAIRAFTNHSTINEYADACYGPTLPPCYVRMDNAHFIHTWVRLLKNVHPTVSVYYKAAIGKLIMTTSREEAKKIVRNILILSQSETYRVLDDGRDTEAEKSYKYLKALITDGNDFDFDEDDPEKPFEEEIDTDEEEDNQPDDKDGDKTKNKKRKISNQWLEWGNEANNEVAVLKQTEKGDRVNAHFNPAVAKKFIDDLPDLPLWSCVIRDEFGFGRIPASSSFVESDFNRVKNSFLKNEVLPMRVDEYVHKYTKFLNGRLKIVNAKVEQSINQEQRIHEPKNQEQKISEPKNQKQRNHKQINQEQTDEEQINEEQINEEQTDEEQKNQDETSQDFDILNHHDKTFDNSEISLLSDIITCPACIRGEKPPGNHKCFICYKPIHNLDSCSSPLSSEEGFSQKRICKKCEKQGNIEIIIASREKENWGGETIKIPTAKNSQTETKNKSMQIIVKKKPAKYLGDQPALINEQIRYNNKNKSKRIVLIKNGSHSDLGATKIDGRAVNAILTCAFDSLYQIIAATICDWPNFQSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HLJ4</accession>
    <name>A0A8J2HLJ4_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Similar to Wrap73: WD repeat-containing protein WRAP73 (Mus musculus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS11061</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5102530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HLJ4"/>
    <dbReference type="OrthoDB" id="308690at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005815">
        <property type="term" value="C:microtubule organizing center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990811">
        <property type="term" value="C:MWP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052778">
        <property type="entry name" value="Centrosome-WD_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16220">
        <property type="entry name" value="WD REPEAT PROTEIN 8-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16220:SF0">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN WRAP73"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5102530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="414" mass="47305" checksum="90B52CCFDDF91A80" modified="2022-05-25" version="1">MFRINKNLCEYSPSGKYLATVLQNELIIKHAKTLQDYLLLDLTDPIESIEWCPNDQYILCTNLKKGVIQIFTIKRKEFNFKYTEGSGGIEKVIWGPDCKSIIIISDLNIYLSIITLTEQTITHIWNIKSSAKFLAINNKTECLAIILTTDKTDKIEIYKSKDWKLSRRLICDKLFSIDGVSWSPNGELLAIWCSIIGKSRILIYSMTTDTHIGVFNVEGNNLPCSDTIEKPIKGIEQVVWSPSGQILAIAGYNETVALINHVTWSVINELHCKPVIKEDDNYLGKIYKEIDITRRDWSNYLSNNLIHDQHIKYTLEQVLDRPINIPIDIEPKYWDVSIAAIDILSFSPCGIAWEPTKTRLLIFSESPIIVEWHPIKKVQLFESPRGMKVINGKWSPNGETIALLGYNKTSIIKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HMN2</accession>
    <name>A0A8J2HMN2_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS12097</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5106100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HMN2"/>
    <dbReference type="OrthoDB" id="6415465at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5106100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="163" mass="18217" checksum="F561D6B49ADC77B2" modified="2022-05-25" version="1">MHHTNLFISVALLTTLVHLSRVLLLLFCMCFLFFMVTVDAGQLLSTEHRTHAATERANDLNCYECDTIKDGEHCVKRYSFTLSTENSTSEPMMWALERNCTNKCEPGCIVIGERTKLFACTDCCEKSYCNTGKGTAADLTTREIGFVLTLVLQAVLTVTLYPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HNR1</accession>
    <name>A0A8J2HNR1_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Similar to LEPROTL1: Leptin receptor overlapping transcript-like 1 (Pongo abelii)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HICCMSTLAB_LOCUS9853</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the OB-RGRP/VPS55 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5100780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HNR1"/>
    <dbReference type="OrthoDB" id="14246at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032511">
        <property type="term" value="P:late endosome to vacuole transport via multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007262">
        <property type="entry name" value="Vps55/LEPROT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12050">
        <property type="entry name" value="LEPTIN RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12050:SF0">
        <property type="entry name" value="RH04491P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04133">
        <property type="entry name" value="Vps55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="40"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="77"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="109"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAG5100780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="142" mass="15625" checksum="F1BB395434C91023" modified="2022-05-25" version="1" fragment="single">FSCSTFCVNFLSTALVTLAFAGSIGMTFVILACALPSYQVWWPLFVVLFYVLAPIPTLMARRYTDDSGSNSNPCLELAIFITMGIVVSSFALPIVLARSPADKGTIEWGACWLTLAGNFVVYLTLLGFFITFDQDDADYSMW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HP41</accession>
    <name>A0A8J2HP41_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Similar to Znf728: Zinc finger protein 728 (Mus musculus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">HICCMSTLAB_LOCUS12696</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5107332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HP41"/>
    <dbReference type="OrthoDB" id="6077919at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001370">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1800.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006612">
        <property type="entry name" value="THAP_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012934">
        <property type="entry name" value="Znf_AD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24379:SF121">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24379">
        <property type="entry name" value="KRAB AND ZINC FINGER DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05485">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07776">
        <property type="entry name" value="zf-AD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13912">
        <property type="entry name" value="zf-C2H2_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00868">
        <property type="entry name" value="zf-AD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51915">
        <property type="entry name" value="ZAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6 12" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="ZAD" evidence="14">
        <location>
            <begin position="173"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="426"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="458"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="488"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="516"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="175"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="178"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="221"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="224"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CAG5107332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="559" mass="63754" checksum="0F973B26ABC3C9F7" modified="2022-05-25" version="1">MKAMKVVCAASTCKYSSKNEDSSDIIFISFPNNEIVELHNNYYICSNHIEDRYFISKTDRIILTEGAVPTLFHHQLKQYTPTTSGSNDDIINTMQLNNCINDVNDCSSTNFRDTVYTSDLHPTSSHINEISSNVSSIDSGDSNLNKYCNININIGQYEDDGDSNDDIGVRYSSLCRLCGQSISDGIDILSDKQINLKTVDKIHLHLPISIDPSESMPLKMCTDCYDKLEISHSLVITSLQTEIRLRKYLNLPNKFNDEDRYRELISLHEIEINNEMCMDSTISTVDDLAAITNKDKSSDISVAELNNQVTENNSTAQVNQTVIQCPNDTPTKLDDRFKYVLQSDLNNLLLEPLTSLESANNPPNNPVVENNVESLIMENDQQQSQEQISLSSRNDKCDIVENIFDGEQTFEDTNVLYSNQNCYSAFKCKKCKDLFNKEEDLLIHELYHMRRTFPDQERKCGHCSSSFFNRKDLQNHISEKHSGLQMLFKCGICDKVYEKRSSLDVHEATHRQDKPYLCDLCGKSFKHSNNLRGHKRTHLDVAKKKRHNCEICGNAFRSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HPB7</accession>
    <name>A0A8J2HPB7_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to spoplb: Speckle-type POZ protein-like B (Danio rerio)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS10289</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5101216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HPB7"/>
    <dbReference type="OrthoDB" id="9997739at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002083">
        <property type="entry name" value="MATH/TRAF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50144">
        <property type="entry name" value="MATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MATH" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="57"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5101216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="77" mass="8427" checksum="0AF70AC0CBA956EA" modified="2022-05-25" version="1">MLLDNSAEFLPNDTLTIQAEVIIDDDALTIPVENLPNSSQSQLAQDLGNLYGSKENCDITIIVGNTRFDAHKLILNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HPD6</accession>
    <name>A0A8J2HPD6_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Similar to CIT: Citron Rho-interacting kinase (Homo sapiens)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HICCMSTLAB_LOCUS11718</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5103855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5919042at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031032">
        <property type="term" value="P:actomyosin structure organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20814">
        <property type="entry name" value="CRIK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046349">
        <property type="entry name" value="C1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001180">
        <property type="entry name" value="CNH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002219">
        <property type="entry name" value="PKC_DAG/PE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050839">
        <property type="entry name" value="Rho-assoc_Ser/Thr_Kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22988:SF71">
        <property type="entry name" value="CITRON RHO-INTERACTING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22988">
        <property type="entry name" value="MYOTONIC DYSTROPHY S/T KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00130">
        <property type="entry name" value="C1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00780">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00109">
        <property type="entry name" value="C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00036">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57889">
        <property type="entry name" value="Cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57997">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50219">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00479">
        <property type="entry name" value="ZF_DAG_PE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50081">
        <property type="entry name" value="ZF_DAG_PE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="10" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="8">
        <location>
            <begin position="1030"/>
            <end position="1079"/>
        </location>
    </feature>
    <feature type="domain" description="CNH" evidence="9">
        <location>
            <begin position="1270"/>
            <end position="1564"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="472"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="992"/>
            <end position="1023"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="13"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="273"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="509"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="485"/>
            <end position="497"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAG5103855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="1627" mass="185238" checksum="CFCEF93F353F35CB" modified="2022-05-25" version="1">MLAIPNQSSKMTKEKLEMALQLRNKKKDRAEQHKKMLELPDLPRSIVNKTNFAVEKLELSMQLKEKMKELDEYQKKMLQLQDKISTSTRLTLTKEKFEIADKLEEKMKDLQEYQQKLLDLHEQTSREARMITAVELQLEEKDIKLEASIKERDKLERDLTAAKSDLAAIKRTLELERQERKDLETTALDLIKGAKRKWEAAEKEKIARLNKHIEAQTVRITELCTSNNEMSSRLQRTQCELETTNAELHKLKVFQIQYKESLAKTRELRRQSVAGVENKLEEIANRAHNQLAEVRMKLEMEIAKNTELESELRNERDSNHCRMSRINVALELAQSELKDCQEQLRSTQAMIPARDQEIETLRKQLKERTQHMQSVSVTEQTVSNLNNEMMKLQLENEQMKKQLENAKSDLNDTLKNLRKSEHLALNLEKKAHDKDELQLRLEASQEKENEQLRKMDTLEDLLQRLQQSVSKLESENACLRRSTDNSKPSTSRTSGVTSAPAEKLSITDKTALEQQIDRLEKQLQAAREKSTADRDAARQAQRDLWKKEKELSDANLDKRIAVREAKTAEDKIKRLEEEKAKLTESLNKKYKEEEEKSKKLLAELESAKASLAEFTRESSRNKLQADSAQRALTQTNGQIEELQSSSAALRRELDATRKQLRTNQDRVDSLNAENKRLTLAISKHNEEKLELEAKLEKLEQEANGYKVNIDLLKETCTVLEEQLTDYERLTSDHETRENTLIQDKMRLQKELEAVEQKLREAKAAQNEEKTKRLLAERAIERLESETSDIESERNGLHSQRDHYKKMAQDLNKQVGVLTTRCGELQCDLAELKRSLESARGESVVVKEECSQHLTRLHEMKDINQDLMADLQSSIDQGQELRLRIAELENVLDEMRQFYQEHEYKSEGTRQQQTKLIDYLQLKLEECSKKKKTVCDKIFKSKQKENIVPIGAGMPVGYRELENQLTRERAKVKALTEQLLAYKAAAASSAPVSPSCGSPELRKHISQSNNTEEENTLSRQMSNQRIRHNIPHRFNLELSMRAGKCAACLEPIQFGKRSAICSECQILTHLKCSLLVPANCGLPGDFAKHLGKTWKNSAESISTLCSSVQTLTIDEPDFGEFNPKHLRNNEGIIAESWVKIPGRGKASWDRKYLRLEGTSLCIYEHKPSQGMAPISKMELTDKSSYGFTITEEVYSAEVPGTAKSDLPFIIRVESNTSNTCWPTSRLDIMALSQVEKKTLVNALKSIAHQNGTKENAKNAMLQTVLRLEKNRLDMNCIVELEQENTLLIGAEEGLYSYQPAHSKMLTAIRGVKRVHQLSLHPHLNLALMIAGEDRQLVCCDLRQLKNNAVAAECSRPAISVTGILTGSDSCHLYQLEGDVLCAATASCVILLKWRSDSERGEFIAIKEIETQEPCSCAIFTKRNLIVGCQKFFQIDLKDYMIDDFPEEDDSSIKAALAGVAKLGIFPVAVLDVSTSAQSTELLLCYNEFGVFVNECGQRTRSIDPTWSHLPFSFAFRKPYLFIAHFSSVEVIKLTPDAFSSATKGPEKTLIELNNPRYLGSAGSKGIYSAVSNSTLDIVKIDGVASILSRMSDSLSSLDSIFTPSLLETLDNNTSKRVHFANISNLFID</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HPF5</accession>
    <name>A0A8J2HPF5_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Similar to SRGAP1: SLIT-ROBO Rho GTPase-activating protein 1 (Homo sapiens)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HICCMSTLAB_LOCUS12352</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5106623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HPF5"/>
    <dbReference type="OrthoDB" id="5981864at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07656">
        <property type="entry name" value="F-BAR_srGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04383">
        <property type="entry name" value="RhoGAP_srGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11809">
        <property type="entry name" value="SH3_srGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.555.10:FF:000026">
        <property type="entry name" value="Rho GTPase activating protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000136">
        <property type="entry name" value="Rho GTPase activating protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.60:FF:000094">
        <property type="entry name" value="SLIT-ROBO Rho GTPase-activating 2 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031160">
        <property type="entry name" value="F_BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001060">
        <property type="entry name" value="FCH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051627">
        <property type="entry name" value="SLIT-ROBO_RhoGAP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14166">
        <property type="entry name" value="SLIT-ROBO RHO GTPASE ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00611">
        <property type="entry name" value="FCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51741">
        <property type="entry name" value="F_BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5 6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="F-BAR" evidence="10">
        <location>
            <begin position="1"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="Rho-GAP" evidence="9">
        <location>
            <begin position="450"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="8">
        <location>
            <begin position="683"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="410"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="655"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="748"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="854"/>
            <end position="893"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="916"/>
            <end position="968"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1024"/>
            <end position="1069"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1079"/>
            <end position="1098"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1186"/>
            <end position="1210"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="127"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="410"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="668"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="748"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="764"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="781"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="857"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="937"/>
            <end position="953"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1024"/>
            <end position="1039"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1051"/>
            <end position="1062"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAG5106623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="1210" mass="137127" checksum="CC8E6D5471986555" modified="2022-05-25" version="1">MESQVALVAELQDFFRRRAELELDYSKSLDKMARSIQMRHKEQKQKREQWPLFSSYACWQQLVNETKNLSRDHAALSEVYSTHLVGRLNQVIEDVQRIYRRCREIGYETHEEILRVLHELHTTMKTYQAYQAESRQAETKLRVAEQQRSKLEVTNVPPEKLARSKKYKLIEKEVTKRKNKYTEAKLKALKARNEYILCLEASNTTIHKYFVDDLSDLIDCMDFGFHNCIARALLMHCSAEEGRQRSLQTSAEQLTNIINALDSRADKQRFLESHHAAFMIPKKFEFQCQRGDETPEPELQKILHSEMEQRLGQLQQRVTSLRTESEEVWKTLETAEASLLEMLTAKDYDCSRYFGENCMPTSRPPETVQIKLRADRQETEEFYLTKFREYLLGTSRIARLDAKQEYIRQSLQDGSNGSPNPSITTSKQKQARRKRIGRLQMNGQPKLFGGSLEEYLESTNLEIPLIMKSCIRVINLYGLHHQGIFRVSGSQVEINNFREWFERGEDPLADVTDASDINSVAGVLKLYLRELREPLFPIIYFEHLMELAQLESKHEFVLKMKQLISSLPRPVVIVMRYLFAFLNHLSEFSDENMMDPYNLAICFGPTLVPVPEDKDQVQYQNQVNELIKNIITLCEEIFPDDIGGIQYEKYISREPDDVDVGDSPTDQVQEDMDSEVYPSEDESENLEATAQFDFNARSERELSFKKGDTLTLYMQVSYDWWRGSVGGREGLIPDKYIMLKIKDEERDKELLKSSSEESMRRRASSSADSAPSSNNSPLMAPTNNPNAWPNVNTSDIITTSSSGTGSLLHHSDVINTNSSSSVISTSSNNVIPATAMANAVNTCISSSQAIISREEQTSVNPSKMTSSPGNEKIHPTDQYHQSSTPNDESESVNDFLDSLSTMSEQANLDDVDDNNQEHQVSSMNAGGLRGSGRKQWKSQTLTETISSQPSLHLNDSDNNDEDNSKEATTFSANRELWQKRANSQTQLTPPVPPTTPKNFRASQEFREMRQKHTPDLVMDLPLAAQDASKKSASSSSLNSSDDENSLAPPTRNGSEKSPSNGPESPDMSTAAERFAKQNQCTLKKNTKSGNTNISNNLTDTGRIKSLVGTDGEINDHVGNLKDNIVRSASNNEISSDNVPLRSPLPPRSTPLIAAKFADMRLTGGSQQVSSFKPQVKVKPTILRKPTVPFPHPHMSPELARKIEKQVQGTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HQ97</accession>
    <name>A0A8J2HQ97_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Similar to Timeless: Protein timeless homolog (Rattus norvegicus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HICCMSTLAB_LOCUS13713</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the timeless family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5109077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HQ97"/>
    <dbReference type="OrthoDB" id="310853at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031298">
        <property type="term" value="C:replication fork protection complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000076">
        <property type="term" value="P:DNA replication checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009649">
        <property type="term" value="P:entrainment of circadian clock"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043111">
        <property type="term" value="P:replication fork arrest"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044998">
        <property type="entry name" value="Timeless"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007725">
        <property type="entry name" value="TIMELESS_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22940:SF4">
        <property type="entry name" value="PROTEIN TIMELESS HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22940">
        <property type="entry name" value="TIMEOUT/TIMELESS-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05029">
        <property type="entry name" value="TIMELESS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Timeless C-terminal" evidence="3">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="146"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="158"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="182"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="220"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="245"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="258"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG5109077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="305" mass="34547" checksum="A86183A07D845248" modified="2022-05-25" version="1">MRESLEWIKESLEEALEDRDEESADGIPLVPITDYSSAAMDSPTFMRFLRACGIEPPSNEQEAYWRIPATMLSSTIRKRCDLIAKALAGDFIQESVTTEKDIVDSVSESDDEDTQRDIDKIKNMFKQKSKLQNKKQVVKSKVFNLSSDEDSGESSSLMKEKSVLVDKDKKIDNGGKEGRGRTNISKVRQGKLNSSRIKSIVNSSDSEMEIETTKITTDSEEAKRIRSENSDSETPVLKKRRVIDSEDDEDKKEEESDFDKLLKSSESKQSRIIISDNESDADEINQPSESKQSRKIFSDDDDDED</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HQG1</accession>
    <name>A0A8J2HQG1_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Transportin-1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Importin beta-2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Karyopherin beta-2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">HICCMSTLAB_LOCUS12609</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the importin beta family. Importin beta-2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5107158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HQG1"/>
    <dbReference type="OrthoDB" id="951172at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031981">
        <property type="term" value="C:nuclear lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000028">
        <property type="entry name" value="Transportin-1 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000357">
        <property type="entry name" value="HEAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001494">
        <property type="entry name" value="Importin-beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040122">
        <property type="entry name" value="Importin_beta"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10527">
        <property type="entry name" value="IMPORTIN BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02985">
        <property type="entry name" value="HEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13513">
        <property type="entry name" value="HEAT_EZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03810">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00913">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Importin N-terminal" evidence="13">
        <location>
            <begin position="85"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="385"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="14">
        <location>
            <position position="957"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00067327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00076938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00080641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CAG5107158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="957" mass="107949" checksum="E1E1C3A640B96ABC" modified="2022-05-25" version="1" fragment="single">MLLWSCSCSGNAIRSGGEEVNREGESGDGRLPFVKDLRRESWLRSVVLLKNTMKMAWQPQEEGLRQILTLLRESQSPDTATQRAVQQKLEELNKFPDFNNYLIFVLTKLTSEADVPTRSLSGLILKNNVRTHYHKFLPEVTNFIKQECLSAVGDPDPMIRATVGILITTIASKGEVSTWPELLPSLCQMLDSQDYNVCDGSFSALQKICEDSAELLDSDTVNRPLNVFIPKFLQFFRHSSPKIRSHAIACVNQFIVSRSQVLMLHIDSFLENLFHLATDEDPEVTKNVCRAFVMLLEVQIDRLIPHMHNIIEYMLVRTQDEKPPVALEACEFWLSLAEQDMCRQALAPYLPRLVPVLVSGMKYSDMDIIMLKANVEEDEMIPDREEDIRPRFHKTKTHTLNPSTNKHSDENGGYDSDGDDGCDDDSSVSDWNLRKCSAAALDMLAGVFRNDLLPVLVPILKETLFHQNWEIKESGILALGAIAEGCMEGMIPHLSELIPYLINSLNDKKALVRAITCWTLSRYAHWVCAQPHETYLKPLMEELLKRVLDGNKRVQEAACSAFATLEEEAGTELVPYLGFILETLVFAFGKYQHKNLLILYDAIGTLAESVGPYLNKPDYINILMPPLINKWNILKDEDKDLFPLLECLSSVATALQSGFLPYCEPVYRRCVSLVEQTLNQHIANTQSPEQFEAPDKDFMIVALDLLSGLAEGLDGHIEQLVMNSNIMQLLYQCMQDPMPEVRQSSFALLGDLTKACFQHVLPCIPDFMPILGDNLNPSFISVCNNASWAIGEIAIKLGHDTSVYIPLIINQLIDIINRPNTPKTLLENTVPDFVFFCDAVASWVTPKDDLKEAFQKILHGFKNQVGADNWKRFSDQFPIQLRERLHTIKADWGWAGNNKMGEQGGWVKPRPLLINIIYLVVVIVSWLLTSQRSGFVLVLELRGTTVVMMIGYGNGTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HQQ5</accession>
    <name>A0A8J2HQQ5_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">ATP-dependent RNA helicase SUV3 homolog, mitochondrial</fullName>
            <ecNumber evidence="5">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">HICCMSTLAB_LOCUS11456</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="5"/>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5103331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HQQ5"/>
    <dbReference type="OrthoDB" id="6692397at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045025">
        <property type="term" value="C:mitochondrial degradosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000965">
        <property type="term" value="P:mitochondrial RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17913">
        <property type="entry name" value="DEXQc_Suv3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18805">
        <property type="entry name" value="SF2_C_suv3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.1080:FF:000001">
        <property type="entry name" value="ATP-dependent RNA helicase SUPV3L1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000269">
        <property type="entry name" value="ATP-dependent RNA helicase SUPV3L1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000446">
        <property type="entry name" value="ATP-dependent RNA helicase SUPV3L1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1740.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.272.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055206">
        <property type="entry name" value="DEXQc_SUV3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050699">
        <property type="entry name" value="RNA-DNA_Helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022192">
        <property type="entry name" value="SUV3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041082">
        <property type="entry name" value="Suv3_C_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044774">
        <property type="entry name" value="Suv3_DEXQc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041453">
        <property type="entry name" value="Suv3_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12131">
        <property type="entry name" value="ATP-DEPENDENT RNA AND DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12131:SF1">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE SUPV3L1, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22527">
        <property type="entry name" value="DEXQc_Suv3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12513">
        <property type="entry name" value="SUV3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18147">
        <property type="entry name" value="Suv3_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18114">
        <property type="entry name" value="Suv3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0347">Helicase</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Helicase C-terminal" evidence="15">
        <location>
            <begin position="359"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="754"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="762"/>
            <end position="782"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00069703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CAG5103331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="782" mass="89166" checksum="17A335BC55A25BFB" modified="2022-05-25" version="1">MLSIKSLLGNIISPNSLKPKLLSRSLTPLINEFHRTKKSSVEDSTRRNNKRRSNLRDKKIPYNVIESLFKPVEVLPDPYDEHLGAEITGKLNKSDVYKIVSAFIQRKEVRDLAKDEGLSADLLKEAVIGFKRYCDNPDTLPVDLHVIISDLIKGSGHVLDIYPYFMRFAKEMYPHLNCMPDLMQISDLRNPAKWYPQARLYKRKIIFHAGPTNSGKTYHALKRFRSAKNGIYCGPLKLLAVEVFSKTNELGTPCDLVTGEERLFANNEDNPAEHVACTVEMARIDVHREVAIIDEIQLLKDNDRGWAWTRALLGIPADEIHLCGEAGAIDLVKKICATMDEEVEVHPYQRLTPLTIENHAVSSLNNIQPGDCIVCFSKNDIYAVSRELELLGKKVAVIYGSLPPNTKLKQAAKFNDPNDPCKIMVATDAIGMGLNLNIRRIVFYSLRKPTVNNDGEKEIDILTVSTALQIAGRAGRHGTQWQSGFVTTFKPEDHSLLKTLLSQLPEPILKAGLHPTADQIEHCAYYLPKSTLSNIIDIFVSLSRVDDSLYFICNIDYFKYLADKIQDINLPLRARYVFCCAPINIKSQLVCVMFRKFATQYFKNELITCSWLCKQIDNWPLETPKTIVELVHLEAVFDVFDLYLWLSYRFPDLFPDQEAIRQIQKEIDLLIQDGIIRLTKLFSRTEPAVKISGEFLRENEDKNADLNQIQRYKDRPKPIYGKGKLTNRLISQGLLTANMIKELRLEWAEELKQENKSISNNDKPRTKKSPEVPKKTKCMCES</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HRX9</accession>
    <name>A0A8J2HRX9_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Alanine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Alanyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">HICCMSTLAB_LOCUS13319</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="16">Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15 16">
            <text>tRNA(Ala) + L-alanine + ATP = L-alanyl-tRNA(Ala) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:12540"/>
            <dbReference type="Rhea" id="RHEA-COMP:9657"/>
            <dbReference type="Rhea" id="RHEA-COMP:9923"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78497"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="16">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="16">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="16">Monomer.</text>
    </comment>
    <comment type="domain">
        <text evidence="16">Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II aminoacyl-tRNA synthetase family. Alax-L subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.7" evidence="2"/>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5108602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HRX9"/>
    <dbReference type="OrthoDB" id="2423964at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004813">
        <property type="term" value="F:alanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006419">
        <property type="term" value="P:alanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00673">
        <property type="entry name" value="AlaRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.310.40:FF:000002">
        <property type="entry name" value="alanine--tRNA ligase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000011">
        <property type="entry name" value="Alanine--tRNA ligase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.980.10:FF:000004">
        <property type="entry name" value="Alanine--tRNA ligase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.310.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.980.10">
        <property type="entry name" value="Threonyl-trna Synthetase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00036_B">
        <property type="entry name" value="Ala_tRNA_synth_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002318">
        <property type="entry name" value="Ala-tRNA-lgiase_IIc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018162">
        <property type="entry name" value="Ala-tRNA-ligase_IIc_anticod-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018165">
        <property type="entry name" value="Ala-tRNA-synth_IIc_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018164">
        <property type="entry name" value="Ala-tRNA-synth_IIc_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050058">
        <property type="entry name" value="Ala-tRNA_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023033">
        <property type="entry name" value="Ala_tRNA_ligase_euk/bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003156">
        <property type="entry name" value="DHHA1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018163">
        <property type="entry name" value="Thr/Ala-tRNA-synth_IIc_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012947">
        <property type="entry name" value="tRNA_SAD"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00344">
        <property type="entry name" value="alaS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11777:SF9">
        <property type="entry name" value="ALANINE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11777">
        <property type="entry name" value="ALANYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02272">
        <property type="entry name" value="DHHA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01411">
        <property type="entry name" value="tRNA-synt_2c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07973">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00980">
        <property type="entry name" value="TRNASYNTHALA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00863">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101353">
        <property type="entry name" value="Putative anticodon-binding domain of alanyl-tRNA synthetase (AlaRS)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55186">
        <property type="entry name" value="ThrRS/AlaRS common domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50860">
        <property type="entry name" value="AA_TRNA_LIGASE_II_ALA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13 16" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="10 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 16" id="KW-0436">Ligase</keyword>
    <keyword evidence="7 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12 16" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 16" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5 16" id="KW-0820">tRNA-binding</keyword>
    <keyword evidence="9 16" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Alanyl-transfer RNA synthetases family profile" evidence="17">
        <location>
            <begin position="5"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="608"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="612"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="727"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="731"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00032577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="CAG5108602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="971" mass="107973" checksum="5BE05E7FE3F19C02" modified="2022-05-25" version="1">MGESMTAKEIRQAYIDFFKGKNHEYVHSSSTIPHDDPTLLFANAGMNQFKPIFLGTVDPNSDMAKWVRVVNSQKCIRAGGKHNDLDDVGKDVYHHTFFEMMGNWSFGDYFKKEICTWAWEFLTQMMKLPADRLYVTYFGGDEKANLASDEECRQLWLSVGVPESHILPGSMKDNFWEMGETGPCGPCSELHYDRIGGREAAHLVNMDDPDVLEIWNLVFIQFNRESDGSLRNLPKKHIDCGLGLERLVSVIQNKRANYDTDLFMPLFQAIQSGTGARPYTGKVAEEDQDGIDMAYRVLADHARTITVALADGGMPDNTGRGYVLRRILRRAVRYATEKLNAKPGFFGSLVMVVVSLLGDVFPELKKDPQSIIDIINEEETQFLKTLSRGRNLLYRTIAKLDNAKVVPGDVAWRLYDTYGFPVDLTQLMTEEKGMEVDMVGYEEAKKAAQLASQSKAGGVDDQINLDVHAITELQKMNIPPTDDSFKYNYTSTDDKNSEYTFESCVGTVIAMRRAKKFVEEALPGEEVGILLDKTCFYAEQGGQIYDEGFLVKESSNQDDSTEIRVTNVQVRGGYVLHIGTVGIGVLKKGDKLQLNIDTARRRLIMSNHSATHALNFALRKVLGTEADQKGSLVAPDRLRFDFTNKGAMTTKDIKSVEESTVGLIEDNRKIYARESKLGLAKTIQGLRAMFEETYPDPVRIVSMGVPIEELEKNPLGPAAMTTSVEFCGGTHLHYTGHIGDFVIASEEAIAKGIRRIVALTGPEAAKALKKAEILQNRVNVIEDNMANDKEFKFTKEHTKNILELLNDVSQATIAAWKKDTLRVKLNGMKKTLDDRERQAKAAVATSVLEKATLIIEDKTGTPVLVEEFQAYNNTKALDAALKKVRTLSPNTSALFFSIDEDTKKIFALASVPKEAVQKGLTANEWIQAIVPLIGGKGGGKAEAAQASGPNYLCLKEAMKIAREYASSKLDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HSJ6</accession>
    <name>A0A8J2HSJ6_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS13715</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5109079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HSJ6"/>
    <dbReference type="OrthoDB" id="7699652at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035280948" evidence="2">
        <location>
            <begin position="19"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="258"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="258"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="271"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="298"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="316"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5109079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="330" mass="36372" checksum="F7949B43DE890E6B" modified="2022-05-25" version="1">MWKSVSLFLFVLLSTSSSLPLEPDFGRSTPQTDDALPTLATELQPPRFDAETASYSEKIIDESNRTLSTELEAPNEDAEIGDFGVDTVEPTISTELEPPTEDAEPFHSGAVYIINLFAIKNASTSEETNEILTDEFAAQNPTVLEPIATVLLVVEEDDEDKPVSLDELAKDLEAEGFKVEKIGEGETQLIKIDMDEIDHKDVELIKSGKLSKVRRRRTLGHGGGLLSKLLNKHSGGDSCQVCNSVGYIPLVIVQQQPQQHYQQPQQHYQPAPQPHYQPAPQPHYQPQPQPQYQPQPQPHYQQPSNGCNTCGGGNHGSYSQASAQSSSQSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HSX7</accession>
    <name>A0A8J2HSX7_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS13974</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5109338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HSX7"/>
    <dbReference type="OrthoDB" id="7700504at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5109338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="178" mass="20718" checksum="ACB75AA8160AA6DB" modified="2022-05-25" version="1">MSKRIRSVNCCNPFNESRVKDLRKFPDEDRWKFPDLDDTSMLCVRCRFRVKDYIPPASEEEEITSSQISVESLSISAEISTQGSSYLELLYSEKNYGVKKLDESNAALENKFQSQFRIVPESTYRKINQDHCSMIAKVKKLYNAESDKSIKNKLLSILPDSWEVSRIASEFNCSQKWY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MAV7</accession>
    <name>A0A8J2MAV7_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Similar to Calmodulin (Strongylocentrotus intermedius)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HICCMSTLAB_LOCUS3029</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001117">
        <property type="protein sequence ID" value="CAG5079506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MAV7"/>
    <dbReference type="OrthoDB" id="26525at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072686">
        <property type="term" value="C:mitotic spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016460">
        <property type="term" value="C:myosin II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000527">
        <property type="entry name" value="Calmodulin-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050230">
        <property type="entry name" value="CALM/Myosin/TropC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048:SF0">
        <property type="entry name" value="CALMODULIN LIKE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048">
        <property type="entry name" value="MYOSIN LIGHT CHAIN 1, 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="10"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="46"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="83"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="119"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG5079506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="151" mass="17086" checksum="F44633B336BE89B1" modified="2022-05-25" version="1">MFKADQLTEEQIAEFKEAFSLFDKDGDGTITTKELGTVMRSLGQNPTEAELQDMINEVDADGNGTIDFPEFLTMMARKMKDTDSEEEIREAFRVFDKDGNGFISAAELRHVMTNLGEKLTDEEVDEMIREADIDGDGQVNYEEFVTMMTSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MDR3</accession>
    <name>A0A8J2MDR3_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS3942</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5083833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MDR3"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="125"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="150"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5083833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="173" mass="19283" checksum="587E36DAD7C7432C" modified="2022-05-25" version="1">MNAIQETSEENSTEAKPIGKSCCCKCTVSLSTVLMVVIIFIKGLARAYVSQKREEISIPVDFGGIRQIRDLLPNSNDVKPEIDNYSSIYSAEAITLIVIIMIEYILTGLVFWYSKKGKYKLIFPYLIFLILAINASLDLFIPATIQSFKLSMQAGFLVLTIGFLIIGKNNSIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MDT4</accession>
    <name>A0A8J2MDT4_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Retrotransposon gag domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS4232</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5084926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MDT4"/>
    <dbReference type="OrthoDB" id="7617012at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5084926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="358" mass="38671" checksum="F1720D54FC5F59F3" modified="2022-05-25" version="1">MSGEEESKPYSLRKHGDAPYAAGLPIVKTRKPKFQFTSPQGVDRTADSGVGKSFYDYEISSDEDDLQPQGSVPVVLGNNAPVTPVVPTAPIAPILPVAPAAPIAPILPVAPVAPIAPVLPAAPIAPVPPVDPRNPVQRSNYENFRLAEQIIAQIVNQNPPLIANPGNILPVRVVPVADDMALAPNQNISLNDALAFVPKFEGNPGELLDFLKCCDEAKSVLPAGAEGNLVKLIYGGKLGVKVKASINSTLPANITELSEKLKKIYIPSKSLFQLQGELGRMFQKEGESVVDFVNRLRKKGREIVDDRKYPFKKLNRVENGVMYLPSRSESTLFVNVSNSELKEGFIPKLKICKGVFVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MEN7</accession>
    <name>A0A8J2MEN7_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">carbonic anhydrase</fullName>
            <ecNumber evidence="3">4.2.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HICCMSTLAB_LOCUS4505</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>hydrogencarbonate + H(+) = CO2 + H2O</text>
            <dbReference type="Rhea" id="RHEA:10748"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="EC" id="4.2.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the alpha-carbonic anhydrase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.1" evidence="3"/>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5087405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MEN7"/>
    <dbReference type="OrthoDB" id="429145at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004089">
        <property type="term" value="F:carbonate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00326">
        <property type="entry name" value="alpha_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.200.10">
        <property type="entry name" value="Alpha carbonic anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001148">
        <property type="entry name" value="CA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036398">
        <property type="entry name" value="CA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023561">
        <property type="entry name" value="Carbonic_anhydrase_a-class"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18952">
        <property type="entry name" value="CARBONIC ANHYDRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18952:SF141">
        <property type="entry name" value="CARBONIC ANHYDRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00194">
        <property type="entry name" value="Carb_anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01057">
        <property type="entry name" value="Carb_anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51069">
        <property type="entry name" value="Carbonic anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51144">
        <property type="entry name" value="ALPHA_CA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-carbonic anhydrase" evidence="9">
        <location>
            <begin position="19"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAG5087405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="285" mass="32202" checksum="A83CB3CD76CBA572" modified="2022-05-25" version="1">MGFTLSELWMLLGCLLMIGLVMYDFLEWTTLMTIGSNISMNSSPSDITISTTSRLDEWESKNPVIKQEIIVEETNQFPIDIATRRVTVIEISEPGVRPCIAGGPLKGSYHLNSIVFNWGLSDDNGSKHSINRTQFPLEMQLIHLKSEHESLEDAILSKNRESVAVVSFLFEPTDNDNNTLDPIIANLSRVTNTNTKVYVPPFYLDTLFPLFESKFYSYNGSLTQPPYSEIVTWIIQSKLLFVSSLQVIVISNFYKLFSHHTLSLIQMCVPDDPISQSSIIHSNNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MEP2</accession>
    <name>A0A8J2MEP2_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS4537</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5087529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MEP2"/>
    <dbReference type="OrthoDB" id="551431at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5087529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="122" mass="14044" checksum="BC82C148CBE51471" modified="2022-05-25" version="1">MPQADASRNGIVKNFPNRSKLFLVLRHDLISRVFPINHRRVFAGASRTSPGSNGIIRRRRPGLLLLTTWNSSSPGIFLYMLRIVCCMYNKHSWFGARSRRLLDNLRFFPQLNNNCSAKSIKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MF84</accession>
    <name>A0A8J2MF84_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Angiotensin-converting enzyme</fullName>
            <ecNumber evidence="13">3.4.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">HICCMSTLAB_LOCUS4897</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="13">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 12 13">Belongs to the peptidase M2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.-.-" evidence="13"/>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5088569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MF84"/>
    <dbReference type="OrthoDB" id="10029630at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004180">
        <property type="term" value="F:carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008241">
        <property type="term" value="F:peptidyl-dipeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06461">
        <property type="entry name" value="M2_ACE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001548">
        <property type="entry name" value="Peptidase_M2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10514">
        <property type="entry name" value="ANGIOTENSIN-CONVERTING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10514:SF40">
        <property type="entry name" value="ANGIOTENSIN-CONVERTING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01401">
        <property type="entry name" value="Peptidase_M2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00791">
        <property type="entry name" value="PEPDIPTASEA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52011">
        <property type="entry name" value="PEPTIDASE_M2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="3 10 12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 6 13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="13" id="KW-0645">Protease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="9 13" id="KW-0862">Zinc</keyword>
    <feature type="active site" description="Proton acceptor 1" evidence="5">
        <location>
            <position position="245"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor 2" evidence="7">
        <location>
            <position position="245"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor 1" evidence="5">
        <location>
            <position position="374"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor 2" evidence="7">
        <location>
            <position position="374"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>chloride</name>
            <dbReference type="ChEBI" id="CHEBI:17996"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="244"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="244"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="248"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="248"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="272"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="272"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="383"/>
        </location>
        <ligand>
            <name>chloride</name>
            <dbReference type="ChEBI" id="CHEBI:17996"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine; partial" evidence="6">
        <location>
            <position position="14"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10 12">
        <location>
            <begin position="11"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10 12">
        <location>
            <begin position="213"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR601548-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR601548-10"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR601548-11"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR601548-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR601548-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR601548-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR601548-8"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU361144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CAG5088569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="383" mass="44834" checksum="710FCD8503E1CFB6" modified="2022-05-25" version="1">MLAIYNSATICAHNDPFRCGLRLYPEISKIMAKSRDWDELQWVWVEWRRRSGSQIRDLYTQLIFLNNEVARLNNFTDAAEYWMFPYESPDFQQDIDEVWNSVRPLYEELHAYIRKKLRDRYGPERIGGHTPLPAHILGNVWGQSWTNLLDFTTPYPGKYYMDVTEEMQAQGYTPIDMFRVGEEFYLSLNLSAMPPEFWAGSIIVDPGDRPLICQPSAWDFCNRLDYRIKMCTKVTMKDLITVHHEMAHIQYFLHYSNLPREFRDGANPGFHEAVGEAVALSVGSPRHLQTLGLANKYIDEPAADINYLFSLAMEKLPLLPFSIAVDRWRYDVFRGIVNREEFNCHWHRMMEVYAGIKPPVLRSEDDFDPGAKYHIPANVPYVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MFX7</accession>
    <name>A0A8J2MFX7_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS2744</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001117">
        <property type="protein sequence ID" value="CAG5078452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MFX7"/>
    <dbReference type="OrthoDB" id="7697635at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5078452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="175" mass="20846" checksum="E6A8800A471EA12C" modified="2022-05-25" version="1">MKCSYVIQMIWDKKEAAMIEQRLMAGLNSLMSETKLEDDRKIMESTFNRRYKFIKTTMGTEPYWVDSWIKEVWCRIRCGNIVRAGKKGFKDWQCRLCQNEDETLEHIFRCRSLKAAANEKIRGGVAEEWRQTFDWLLMQTLRGDPIKEICEYIQRFENLVKAGDIAMEDELVRLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MG81</accession>
    <name>A0A8J2MG81_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS2986</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001117">
        <property type="protein sequence ID" value="CAG5079338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MG81"/>
    <dbReference type="OrthoDB" id="7701509at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5079338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="266" mass="30315" checksum="4E2A2AFB00D867A8" modified="2022-05-25" version="1">MVDDLCLLWVSMKKPSFVNADGDAFFDFPFDEKELDFAIENLNIRSSPGLDYGIDYKIITMLPQEDKNLLLNICNEALINSEIAVNKIGHALAELGLELSAPKSKLCVFSRGNKELQLKNQGKIIAGRKVWKITINGTEIQNSEWVCFLGMYFQSSLSWDKHIEEIRKKCQSPLKTISCLRHTWWGANPTLLIGLYRALIRSRIEYGAMFFHKLTLGQINKIDKIQFRALRAALGYRASTTTNVILAEAKEPPLYLRFGFIYVTTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MGS0</accession>
    <name>A0A8J2MGS0_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Similar to Lrrc4b: Leucine-rich repeat-containing protein 4B (Mus musculus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HICCMSTLAB_LOCUS5273</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5089530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MGS0"/>
    <dbReference type="OrthoDB" id="26525at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000483">
        <property type="entry name" value="Cys-rich_flank_reg_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050541">
        <property type="entry name" value="LRR_TM_domain-containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24369">
        <property type="entry name" value="ANTIGEN BSP, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24369:SF210">
        <property type="entry name" value="CHAOPTIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00082">
        <property type="entry name" value="LRRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="344"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="domain" description="LRRCT" evidence="6">
        <location>
            <begin position="227"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="419"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="423"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAG5089530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="470" mass="53202" checksum="B731193428141068" modified="2022-05-25" version="1">MKLVSTDVTESVGHSDEYRQNASFYKNQISNNWITFKPKNFDIESIRFEECPIGSIQSEAFGLQIFSKIEQFHLINTNVSIFQKDLFQKLPNLKNFAVQNNLITFAESYLLSGPAEQLETLQLDSSIQNLDVLRNITFQELPKVQLLSLQGNNIFFIPKSLFATFPNLRSLYLDSSNILRINSNAFDGLISIQQVFLRNNLLSELPKDLFDPILGANKDFKVALSGNPWKCDCNLIWLKELMEEFRNLVLEEPICAMPESNKNLGFLEADFCEEAKIWCSNLEDLIEISINCEKGGKNMNGSIRNASKEGNISFAGFDCVWKSALIKKENDCAKRLWLANEDKAMVLSLYTIGTILFGVFCAVGCFLIVRKNKGMVKANQRVVVEERGSITLPGGEACQRDNKGEIDYFTPIEANEGNEYESIQDRRKEESKSDNCPPPLPPHPFHGVKSVSLLMEGSHGKREVIDDYLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MHP1</accession>
    <name>A0A8J2MHP1_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Gustatory receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HICCMSTLAB_LOCUS6332</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Cell membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the insect chemoreceptor superfamily. Gustatory receptor (GR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5092711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MHP1"/>
    <dbReference type="OrthoDB" id="7682888at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050909">
        <property type="term" value="P:sensory perception of taste"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013604">
        <property type="entry name" value="7TM_chemorcpt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08395">
        <property type="entry name" value="7tm_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 7" id="KW-0675">Receptor</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="16"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="98"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="124"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="182"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="225"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="302"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="340"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAG5092711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="371" mass="43037" checksum="FFAAB35C558AE130" modified="2022-05-25" version="1" fragment="single">MTAACIFNNVHTKYSIFFAQIILSSIDSILAHALKAAKKSHKMTQCCCSNSSFISLRLLIVLFKMFGLAPFATKIVIDNENNQEKNTFKIEFSSSVLGSIYNLLIVLIILSEIIYNYILWPMDAYILLQIYNLFKKIGLITIILSFLFRRKSLIKIIETLYAINNAFDQSDILRPLSHREKFYRIVTVIVYLTISLILMTSYIISEIFYLKKNSFIANINIVVEYAIIFTIGWFITQYSLLLIFVYHKLCMFNESFELCFTGENYSIDSQNCFVCENTLLKFISLRKLYQNTYSALSDIARLYSLPILVAFVIIIPKLISVVNNTIDYNESRDESILLKVFNNLMMIFLYFPVINLTVFATKINEEVRILF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MI46</accession>
    <name>A0A8J2MI46_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS4296</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5085178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MI46"/>
    <dbReference type="OrthoDB" id="7656507at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20898">
        <property type="entry name" value="DAEDALUS ON 3-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20898:SF1">
        <property type="entry name" value="MD-2-RELATED LIPID-RECOGNITION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035327356" evidence="1">
        <location>
            <begin position="21"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5085178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="426" mass="46606" checksum="41C65BC5F69CDA9C" modified="2022-05-25" version="1">MNSIIFGLLVAILSVNSAFSQGVKLKLLNLKMDVPSSPYFENWSGEIVNDNTLSLKTPVKKDLPEDMRLSAIIEFDGNVVGDTDMTVCEAFDDETIGKDLLAKGIPDGKFPKNCPVKAGNDLEISKYVIEKEKVPDSAPDGPFKVDVTIYMPDQDPIVKIHVDGEISHDLQDKLENKYINSREASVNIIISLRVKKMKLQSILVLSAILSTNLVLGNDPMAKIKVDKIIVNSLPNPYYDKWTAEFYSPGDIISAKLPLKKDLPETIMPTAQFKFNVITVKTVAGNPYFDEMTAKIDSPDTVSFKTPVKKDLPDNIMLTAVAQFAGAPLGDFEVSLCEAFENDPHGKEFSSHGLPKGVFPELCPVKAGSDYELSKIKVENDQIPPGFPDGDVVLDITLFEPGNDPYVTVHIEGALSHSVPGVPGIGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MJT9</accession>
    <name>A0A8J2MJT9_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS2973</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001117">
        <property type="protein sequence ID" value="CAG5079283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MJT9"/>
    <dbReference type="OrthoDB" id="3694230at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="83"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5079283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="158" mass="17887" checksum="D518426CE588D5D1" modified="2022-05-25" version="1">MKQAQYDEYKNTLEIQQKNHLKKDAIKYNDKGSTASAETDKFDGSLRQAIYKTIEEQDTLLSLMPLPDDDQAFKHPKDTVTVIEELRTVNSQLRSLVESLLSQLEAKEQEVKQLTQRLHTVSAAVTDEMSLNEGHSLRLAPLPPLAPLEMPLFDFSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MKS8</accession>
    <name>A0A8J2MKS8_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Gustatory receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HICCMSTLAB_LOCUS3641</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Cell membrane</location>
            <topology evidence="1 8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the insect chemoreceptor superfamily. Gustatory receptor (GR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5082742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MKS8"/>
    <dbReference type="OrthoDB" id="6366728at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030425">
        <property type="term" value="C:dendrite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043025">
        <property type="term" value="C:neuronal cell body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007635">
        <property type="term" value="P:chemosensory behavior"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008049">
        <property type="term" value="P:male courtship behavior"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050909">
        <property type="term" value="P:sensory perception of taste"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013604">
        <property type="entry name" value="7TM_chemorcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21143:SF133">
        <property type="entry name" value="GUSTATORY AND PHEROMONE RECEPTOR 32A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21143">
        <property type="entry name" value="INVERTEBRATE GUSTATORY RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08395">
        <property type="entry name" value="7tm_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 8 9" id="KW-0675">Receptor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="30"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="79"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="108"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="193"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="229"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="310"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAG5082742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="332" mass="38237" checksum="20CFA96D398CEF76" modified="2022-05-25" version="1">MFVYSTTILVLKLLDQNHIESAMVKIIDKILLMSGIFTVLIVWLTYVLQQKTIVNILNRLYDVNNSLKKCRKYTLESDSFVYIFGFCNFALCFSIAILEIIVDSKYTFIMWAAPFIVGTSVFAQYTIFLSIIVQFLKNINKTLLKIGNLSSKNKIKVSFISKILHEDSLIKDIYNINFDLINLCEISNQIADFYAIPILLLTIYFVPTTTYNLYFMILSFIVNDGKDSITLYLDCGILIFCIFLSYAALTTNVTRITREVRTTMHYIYLLSHQCTLNPKAKEVLADFSCSLIHRRLEFSTYGVMNLNGSLLQNIFGTIVSYLIILLQFPHQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MLG7</accession>
    <name>A0A8J2MLG7_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Odorant receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HICCMSTLAB_LOCUS6316</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Cell membrane</location>
            <topology evidence="1 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the insect chemoreceptor superfamily. Heteromeric odorant receptor channel (TC 1.A.69) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5092690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MLG7"/>
    <dbReference type="OrthoDB" id="10280342at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005549">
        <property type="term" value="F:odorant binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004984">
        <property type="term" value="F:olfactory receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004117">
        <property type="entry name" value="7tm6_olfct_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21137">
        <property type="entry name" value="ODORANT RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21137:SF35">
        <property type="entry name" value="ODORANT RECEPTOR 19A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02949">
        <property type="entry name" value="7tm_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 10" id="KW-0552">Olfaction</keyword>
    <keyword evidence="8 10 11" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="9 10" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="29"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="121"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="167"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="267"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU351113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAG5092690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="392" mass="45778" checksum="92C3069B7D7E8CC2" modified="2022-05-25" version="1">MNLITSSWKVFTWLGLFRPIKWTGLKARIYDLFTVIVLFCNYTFFACGVMDIDFTHLDFYADIELITLMLQFVENTPKILCMLLNRNDLIEIEYKLKNDHFELKDDEEKEIQKKFDKFSRAVLLSYATLQVSALIYYTIGRILAMESPILLPYRSNIPFNYSTSNEIYLLTSIDQLFSVSSLIAINGAFNLVFTSTMHQICTKVRILKYRFNVIIEQLEDDAKIDYSVEDDTKKKIFMTERNQDELIANWVESHNELLSLYDFTKSVFAKAVFIHYVINSIVICTLAYILSHCEIDNIFFGNVSYFCVKCTQQFLQCSSAHQITLEFEDLRDMIFTTNWFATKISIQKSIIIIMSKSIIPVEFISGYFVTLSLDSFKRIIKLSYTIYNVLEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MLX2</accession>
    <name>A0A8J2MLX2_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Similar to MROH1: Maestro heat-like repeat-containing protein family member 1 (Homo sapiens)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HICCMSTLAB_LOCUS6526</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5093015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1884734at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055406">
        <property type="entry name" value="HEAT_Maestro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055408">
        <property type="entry name" value="HEAT_MROH2B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048465">
        <property type="entry name" value="Maestro-like_HEAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045206">
        <property type="entry name" value="Maestro_heat-like_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056282">
        <property type="entry name" value="MROH2B-like_N_HEAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23120:SF0">
        <property type="entry name" value="MAESTRO HEAT-LIKE REPEAT FAMILY MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23120">
        <property type="entry name" value="MAESTRO-RELATED HEAT DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21047">
        <property type="entry name" value="HEAT_Maestro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23210">
        <property type="entry name" value="HEAT_Maestro_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23221">
        <property type="entry name" value="HEAT_MROH2B_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23227">
        <property type="entry name" value="HEAT_MROH2B_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="MROH2B-like N-terminal HEAT-repeats" evidence="5">
        <location>
            <begin position="120"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="MROH2B-like HEAT-repeats" evidence="4">
        <location>
            <begin position="294"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="domain" description="MROH2B-like HEAT-repeats" evidence="4">
        <location>
            <begin position="683"/>
            <end position="876"/>
        </location>
    </feature>
    <feature type="domain" description="Maestro-like HEAT-repeats" evidence="3">
        <location>
            <begin position="929"/>
            <end position="1153"/>
        </location>
    </feature>
    <feature type="domain" description="Maestro/Maestro-like HEAT-repeats" evidence="6">
        <location>
            <begin position="1366"/>
            <end position="1638"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="82"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="82"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF21047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF23210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF23221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF23227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAG5093015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="1643" mass="180343" checksum="969CA75196853EFD" modified="2022-05-25" version="1">MKCQSEDKMSELSAVVGALLDGLNDKSDQVTSCINESIRQISTRSPAVVLHATIYYFELHKKITPAHTSAILRIITDTLNSISTTNPTTDPNDNSIENSNDNSNEESNSSHQTLEMPTLADSVAELAVEKLSEFEVEATEVLVALGNSFCNQAIGNILNKFEFGSIPKSSAMIRALGLIAASNPYDVVPFIKLTLTFVLPFLNQAQEEHQKLALCFVVGKFAEAINEYLGNLGMNSESRITRDSFAEEASFVFEFLTGSSWLKPVSATKNRLAEAVLSALCPILLLLPTGKNLNETIKLIPSVLNFCKHPTTRFAATKLIATILIDNDRHNDNQARELLRPHLEPIQQILFELVNVTPAFETRSSLSRDALLTHYEVLQCYRAIVTLYPEEGLDLVLHHLRSPAPQSHRGRALVIIRHLINTLPTEDDLSLQRIALSIQNILGDSGGATVRYLAGPIIALLAHPSLNLLPSQRANLIRFIIIRCGDDTESQAYEEALFLLANTVAGAENWLWTALLKALLDPTYSLAVVPILRGLAALVGKVVHQMDNEGSNSFKEFSGSKVLKRCLELLDDDKNCLAVVSFLKSAAPLFGHQLKPEWDISLGKISSILEEGNDEWKNQMVELMETSRLLEGADWAGKLSNEMVQGETIKSSTTIYLAAVTDNPNHLSTLVDLSRLNPFNEVYSQAVGIAAKRHLSVIMTRMQEACDVIDSQKNPTKLFGLMKNASAVTVVEATKASLLRCYGEIFATAKDSELVYKTYIAENKHVLPWIVKQLTDCKEVTTKEAGLFALEQLAKIVAAKPNSEDLTSSVVPSLKTKGACLATLLSLLQSHTGYRPIQLYPQLLKTMIALLKVPPMLTVEEQQVLMGTILDKVIGSSAEIDLILKKESKNYVVQRLGAVSSAMVGDSANNLAEFVEIIMPWMESKTPVERKMTLLVLRTTLKSYCHALKYTYPEGKLEAGKLLGRIICWSADSERLLRPIIIDSLALTLEIAARHHSSGHPFVEGSNDLEESKLRLISEDIKSPDDVYEGVLMLAKTVCQRVTPGEVVAMAEGLIEGFLLREENSLAAGITLSQLFRIRGDEIPRSDLYLIDNIVTQMRQIENASCRHAAATAIKSLTLHHPEEVIEHLLHQPLPPDRGTEESWRELGSDEETGLVAVDFLVNRLENNNLFAEAPSPTNGSLTNRSDVNKTASLASLAAVIALGHVLQSAKSELLINSRLAELITCLIKYLAGWLHADTPASVLSTKFGFVPNRKACKLNPYRQVYTVLTNLLTVIDINVASGLLNDNPRFESDTQASDSLISTVRSVLRCFGRKVGSKDDLLISVAQSIGKLVTSQIATQRAVAIAFYGELIGQVDADPIWLDSIITTLLEARSDSSFLVRKLAIQGLSNISKLDAQQLNEFYDNSVAALLDGLEELPTNGGLVAGGGSQVILESLRGLETLLGLQTTGRAVSPRVVLSLKSFVDKQDNWDIRLAAVGALGAVSRGWLKSLKTYDDDDVSDHLLGCLPCLTVRLEDVNSLVAKAARETLVSFSNLLQSLSLAQVIRGHLSSNAEFDVEHFYRELVKVLVIDLPVRAQEMRNAMVRGYSRSEVAATRATAVLILGFFGQPRPEDVQRMLQLLRDKDNSVKSRAARALAFGFTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MMU7</accession>
    <name>A0A8J2MMU7_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Similar to nrf-6: Nose resistant to fluoxetine protein 6 (Caenorhabditis elegans)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HICCMSTLAB_LOCUS7805</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5095631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MMU7"/>
    <dbReference type="OrthoDB" id="207378at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002656">
        <property type="entry name" value="Acyl_transf_3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006621">
        <property type="entry name" value="Nose-resist-to-fluoxetine_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052728">
        <property type="entry name" value="O2_lipid_transport_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11161:SF72">
        <property type="entry name" value="FI21449P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11161">
        <property type="entry name" value="O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01757">
        <property type="entry name" value="Acyl_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20146">
        <property type="entry name" value="NRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035215938" evidence="2">
        <location>
            <begin position="26"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="197"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="278"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="318"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="369"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="441"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="464"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="503"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="533"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="559"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="domain" description="Nose resistant-to-fluoxetine protein N-terminal" evidence="4">
        <location>
            <begin position="51"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="Acyltransferase 3" evidence="3">
        <location>
            <begin position="276"/>
            <end position="575"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF20146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAG5095631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="619" mass="70865" checksum="0CE61891BB0D9DB5" modified="2022-05-25" version="1">MTLPKNVKNLCLLFYGLFLCIFVKAQSNNLEKYSPVYAVTFYADILKNSSCKSDLESIRIGVDKKILWSLKDASGEPKPGFFYGNNFWPGIKSQCLDLRNTKPLELDPEFLKNVSKYRNIDEEFPPFDLNYFIVFFWHNKLLQLEAYIQQTIGFMTFGMAKMTTNGFLIGKSSPLGNYSPTKCPIKAITSINRRIDFSIVLTLSILLAVIGTAYDCIVHQKRLDPAESSKDVADNTSPAPEGRQPGTLERFLLCFSVFTNTKSLVNTESSKDSVNSIVGLRLLGMIWIFLIHAVFYSNDALDNRLTAWKLSVEFTNQIITNGSLAVDTFFCISGFLICWSFFGKRIGQEPKPVRRFTWFGYLNLVFNRVLRLGPVYFVIIGIAEIIFGMINKTSAFIAAEDPYYYCSNYWWRNVLFINNLFDWNEAVTICLSWSWYVANDMQFYIIGTFLLLLSDVYFYTSAALLLVLLIVPAIINGFTSYAYEYINTTDQMWSIMNVVYSPPWIRIGPYLIGMITGYILRRMKGKLNVSRKTLCLLWIVGSSCNIVILFGLYGKNFSFVSAAFYVAFSKIVWGIGDTIYGFDSFDLFVRILHKIFRRLNYLGQCIWISISPWLISEVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MN73</accession>
    <name>A0A8J2MN73_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">THAP-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HICCMSTLAB_LOCUS8211</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5096441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MN73"/>
    <dbReference type="OrthoDB" id="7698091at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052224">
        <property type="entry name" value="THAP_domain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006612">
        <property type="entry name" value="THAP_Znf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46927">
        <property type="entry name" value="AGAP005574-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46927:SF3">
        <property type="entry name" value="THAP-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05485">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00692">
        <property type="entry name" value="DM3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00980">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50950">
        <property type="entry name" value="ZF_THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="THAP-type" evidence="6">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAG5096441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="264" mass="30568" checksum="727AC44BE274CFFE" modified="2022-05-25" version="1">MPKCTAPHCNNSSEQGYVLKCLPTNEKLRAKWIKNITRKYTIKDWSPTSDSRLCEVHFAPEMWENRRLDNLQKLKKHAFPTIFGHHITKKTFIAKNSISTQTENDELALPVIRTPVSTCDQSTSTEEGESESQKFVTLKRAYSVVRNRVKSLQLKNKVLTDVLRTDKYRTALYSLFNEDQVQYLITDQRKLQHWSRETVERAVKLRTVCGTHGYKELQSQGIPLPCLRVLQRSRPKAYSQSETPQPTTTLSPDELLSIINDDWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MNA8</accession>
    <name>A0A8J2MNA8_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Similar to MSH2: DNA mismatch repair protein Msh2 (Homo sapiens)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">HICCMSTLAB_LOCUS7014</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Component of the post-replicative DNA mismatch repair system (MMR).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the DNA mismatch repair MutS family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the actin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5093688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2688364at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032301">
        <property type="term" value="C:MutSalpha complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006312">
        <property type="term" value="P:mitotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.110:FF:000002">
        <property type="entry name" value="DNA mismatch repair protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1420.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1170.10">
        <property type="entry name" value="DNA repair protein MutS, domain I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.110">
        <property type="entry name" value="MutS, connector domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007695">
        <property type="entry name" value="DNA_mismatch_repair_MutS-lik_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000432">
        <property type="entry name" value="DNA_mismatch_repair_MutS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007861">
        <property type="entry name" value="DNA_mismatch_repair_MutS_clamp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007696">
        <property type="entry name" value="DNA_mismatch_repair_MutS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016151">
        <property type="entry name" value="DNA_mismatch_repair_MutS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036187">
        <property type="entry name" value="DNA_mismatch_repair_MutS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007860">
        <property type="entry name" value="DNA_mmatch_repair_MutS_con_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045076">
        <property type="entry name" value="MutS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036678">
        <property type="entry name" value="MutS_con_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361:SF35">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MSH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01624">
        <property type="entry name" value="MutS_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05188">
        <property type="entry name" value="MutS_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05192">
        <property type="entry name" value="MutS_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05190">
        <property type="entry name" value="MutS_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00488">
        <property type="entry name" value="MutS_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00534">
        <property type="entry name" value="MUTSac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00533">
        <property type="entry name" value="MUTSd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48334">
        <property type="entry name" value="DNA repair protein MutS, domain III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 10" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7 10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA mismatch repair protein MutS core" evidence="13">
        <location>
            <begin position="317"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="domain" description="DNA mismatch repair proteins mutS family" evidence="14">
        <location>
            <begin position="629"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="909"/>
            <end position="928"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="373"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CAG5093688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="1336" mass="150688" checksum="D5FD95B523CB0DDA" modified="2022-05-25" version="1">MVSPVSRMVEVDVKSRRLELKSSSTIQFFKRSDYYTCHGEDALFVSNEVFKTTSSCKMIGAEPNKLESVLVNKANFENLIKDLLLVRRYRVEVYEDKGTGRNRNWVVEYKGSPGNLSQFEEILFDSGDIEADVIANGAIMAVIMGMEGKSKVVGLSCIDTMSSVIRVAQFMDDEAFSNLEALTVSNSPKECLLIQSENSQDFETIKGIIERNNVMITLKKKKDFDKESLIQDLDKLLKFKKGEMESAHIYPETNLEHAMSATAGIIKYLDLLSDEGNLGQYKIEDLKQYHFLKLDSAAIRALNIDPPPEYRLGGNRGAATSIHELLDKCKTPQGHRLLSLWLKQPLQDLAHIKERHDIVEYFVNNSSVRSEVSNEYLRQIPDLEQLVKKLLRKKARLRDVYKIYDCVNRLPQLVEALSDDSTPAALKSMILEPLKENVADMEKYQQMVEETIDFDAKKMKSQLSKAAEDLGLEAEKSIKLECTSQQGYYFRVTMKEEKIVSRSKNYTVFDSIKSGVKFRNGTLEALNQEYLDDREKYEAEQKIIVTEVINLAIGYCSTIKNIAAVAAVLDVLCAFAVAATNTQKTYVRPKMLPSDAGEMKFIQARHPCVEGQEDVHYIANDIEFKRGESEFHIITGPNMGGKSTHLKTAGIVVLLAHIGSFVPCDEASMSMVDCIFARITILAENIPTVKNYHVTALVKGEDVVFLYAIKEGVSDQSFGINVARMVNLPPEVIEYAEKKLTDLEENQHIYEGYFEGPYSAAEKRKFVVEADALIEEFTGKCKALDPSLPEDELMKKINEKMKWLQLLSKVHFKFPDIKCLQLLSVSFKAMCYRLHMVITLNENVNGGTFPKCYHCSGYTCQRNCVEGSSAKVVIEIGNKYTWVITPHSGLRRHFSLFGIPKCDSKTHVQNTHPPPADKLNAGGGTSTSSRIKSDYKSIAKKLKSLKLSELTTTKIPRPSGPFCVFCNSVKLYREKKRLITHPLEAMCYTRANPLYQKLVNGYCTDTIEVLGIPNVDVVSPAEALLSDGSFSVLRTFVDHLFHQMELTATLRKPNAVLMFCEPLAMQPVLRKQLLHYLFQEVKVARVCLVPKPLAACAMLDVETCVVVDSGALSTTVAVVIGGRVIPHRWRLLPVGGWHVAYHLKQAMHWQPKEYHQIPISHLDTMAVKERCRLSYNIESEELRKGPTKREHINLRVDSYAEYKQFWKVSLGPELYVAPEMMYISLGLPQIIKDVTAGLSENTMQDCLSHILLTGGNTDLAGFALRLKKDLRETLPEYESVLEVRSCPGTHSWNVAMGSTYVPLAVHPDKTPPEYVEGNPFWLSREEYVLFGCQSLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MNY4</accession>
    <name>A0A8J2MNY4_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HICCMSTLAB_LOCUS8894</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5097821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MNY4"/>
    <dbReference type="OrthoDB" id="3561125at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050329">
        <property type="entry name" value="GLI_C2H2-zinc-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19818:SF139">
        <property type="entry name" value="PAIR-RULE PROTEIN ODD-PAIRED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19818">
        <property type="entry name" value="ZINC FINGER PROTEIN ZIC AND GLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035257644" description="C2H2-type domain-containing protein" evidence="6">
        <location>
            <begin position="19"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="65"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="97"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="128"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="352"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG5097821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="440" mass="52196" checksum="A130140E881F4D1E" modified="2022-05-25" version="1">MRRKAAICLSLLQLFVHSKIELATTYVCNSQKVPSWDVYGSFVPVPAKTAEPSFTPVNAAPYRRFWCKTCRKIFPSKYLLKRHMKLGCKMEPRASQYACNLCPYKSTYKANMDRHVRNVHESAAALRYRCDLCGFYSNYRFCVRRHLKSVHRITGPEEKQLKAQKKKDTESEPEFINEESLEEVYEEVYEEEMITYEVVEEIEVEDAVEGEKSYDMEEIVEEEIVEEAEKKNEEEMIVEKKEKKVAVKKEATKKKNKKKYKRRSKMCQCEYCGNIYAWSTSLARHLRECRKRKDNKMVNDEPKENVEIKDEESVKKPVVKSVKILRSGAPEKKSSKQYEHEMKKYKSADGMYTCWGCGRKYHWASSLSRHRTIHCGPRNKMKYVCKLCSYKSGYRGNFLRHLKTPRHKRNARFKKMQKIMEEAIRNEDEEEEEFEEEYDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MP14</accession>
    <name>A0A8J2MP14_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Similar to snx14: Sorting nexin-14 (Danio rerio)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HICCMSTLAB_LOCUS10315</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5101242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MP14"/>
    <dbReference type="OrthoDB" id="5957963at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.167.10">
        <property type="entry name" value="Regulator of G-protein Signalling 4, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003114">
        <property type="entry name" value="Phox_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036305">
        <property type="entry name" value="RGS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044926">
        <property type="entry name" value="RGS_subdomain_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22775">
        <property type="entry name" value="SORTING NEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22775:SF44">
        <property type="entry name" value="SORTING NEXIN-14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02194">
        <property type="entry name" value="PXA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00313">
        <property type="entry name" value="PXA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48097">
        <property type="entry name" value="Regulator of G-protein signaling, RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51207">
        <property type="entry name" value="PXA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="domain" description="PXA" evidence="3">
        <location>
            <begin position="93"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="PX" evidence="2">
        <location>
            <begin position="492"/>
            <end position="603"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG5101242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="753" mass="85331" checksum="8B34669A56202F00" modified="2022-05-25" version="1">MTNTGFLFSLLLIFVVIVVAILYSIIWAIVSFVLFNIGRFWGEEILERIIILLKLDKKFSSNKFNSNKTCKVCRGDNCKRHKPSVNNSHVKIPKDLDSALQNLLEKVLQTYVCTWYSDFSSNEAFLQQLRLTTTIAIRNIISRLLNTQVSELIFNNLIPIALQHAQDWRVMSECAKKKGGKPEDYARDYLGHRIHPAAYSRDEELSYLRGLVSGLLPYLLPSTYISTNNKVLLREILANWVLLPAIDALADPDNINFLVKLGTSYEVLLPGEIDSVNVPVLQTWITPVIAIETSNDPLKPSLDQVLNDPQLLYLFMQHIKETGPMTEEIEENLYLDAQNIYSTYLDPTGSEYIHLPWHITQGLQQILEGGPSKIQELRTSRPLYQAHQEAHALLEAICLPSFHHSYELYKLLCGSPIANLTSKSSSQTSLSGASGVGQKLSYQLGKIRGALRASTVDGATFETPDVFHAEEVDCAPRTYQDDSALYIDKASDRDLTTWRVTVPHVDGNGSHPLYMIEIHSSADNKPWSVLRRDQDFHTLRSRLLEFHGDREMNDSPLPTRKNQYVSLAANRQRYEDFLQKLLAKPTLRSSELLYIFLTVPNFKPYFNNYSTPDIGVLYQNVAHKLRKEKGQNLDKFMNVFLASTVVETEQVNLGIDPINDNNFGEPTTKGKDLLAGPFENNLNISDVDQQNLPFIVPKKHHLAKCIIFYINLRLAGSFAIALKFRPILQQIFGQNTSKITERRQSGDGYQIAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MPQ0</accession>
    <name>A0A8J2MPQ0_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">WH2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HICCMSTLAB_LOCUS10888</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5102184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MPQ0"/>
    <dbReference type="OrthoDB" id="6157464at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003124">
        <property type="entry name" value="WH2_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02205">
        <property type="entry name" value="WH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51082">
        <property type="entry name" value="WH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WH2" evidence="3">
        <location>
            <begin position="273"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="492"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="587"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="342"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="666"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="60"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="97"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="137"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="159"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="178"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="498"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="508"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="597"/>
            <end position="640"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG5102184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="702" mass="79643" checksum="60FE83BE437756F2" modified="2022-05-25" version="1">MPGAGGQQPQRTTFRPPWVKDGPNPLPMPSAPWALNSRRESKTSSEDAPAFTKVTLKSVAKPADAAAPQKQPAEPQPKKLSKITIVPTQPKSDKNATSKLATSNVKQSENERSKTSTGPKLGQKNESRTETPSSKPQLERQIRVEKSQSRSDNRVPLSKSESSTGAPTLSKSSSRAAIPPPPPPRPPPPPPARVVLKDLPELTKTQQEKLEMLKSRPRKRPDWACMMKELESGKKLKHVNCNDRSAPIIERVSKVTADPGNAHFVFESEKSNMHNKLLQQIQSGVKLKSVKTNDRSRPVLAGLRKFRRQLTIEEQMHKADTAPVDDAVPDEMDDIDAVRDDLQSTKQMLALELRNKEALERDNKRLQARLLNLEAENERLKLQQNVTEYKKQDEKIVESLKNEVDQARKDVEKVEKEFSVVAEERDRTKLELEDLKKMYAVLEKRMKADYYWDWEQVEPEPIVEFPPESEATWYNVSGMALAGCPSAKDVAKIASQKSIEKAEKTPSESEEEEEEESSEEEDEDEDPEAVAERRALREIKLLATKIKNFKDKEDNSKKERHALKEQIKQQLKLLKEEKKKYKSLQKEVDKMAKLMADTDEEDGDEKEEEEVEEESESEEESESEESEEDEESEIDDETADSEDRKTKLQAIAKKHEGRLASLKKGNYLLKAQVDRLKDDLAKQREESLSLQEDLDSVLAELG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MPU5</accession>
    <name>A0A8J2MPU5_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Olfactory receptor 190</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HICCMSTLAB_LOCUS11009</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5102426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MPU5"/>
    <dbReference type="OrthoDB" id="6597368at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005549">
        <property type="term" value="F:odorant binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004984">
        <property type="term" value="F:olfactory receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004117">
        <property type="entry name" value="7tm6_olfct_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21137">
        <property type="entry name" value="ODORANT RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21137:SF35">
        <property type="entry name" value="ODORANT RECEPTOR 19A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02949">
        <property type="entry name" value="7tm_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0552">Olfaction</keyword>
    <keyword evidence="8 11" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="9" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="33"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="67"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="266"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="296"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="344"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAG5102426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="393" mass="45486" checksum="B1A26C1BEB24149B" modified="2022-05-25" version="1" fragment="single">MTSILPQSFFILTCIGVWRPVEWQGWKCVLYDAYSWFVVITNFAFSLSQFLDILLVRTSINELTNNLTMLLVMVTACGKIVGILFNRNEILEILRSLEEKPFKPRDQFEEDIRKKYIHISSFLTRSYSVYLTIGISGILLTRIPEAKLPDVLPFSSWLPYNYSKQNVYLITAAQQVFNSLISTYAQVGFDTLFPGLMMYVSAQTNILQYRYDKVIKALERLNDFNHSANQNKKIAERNIITEWVECHIAVLSFADYVYEIFSKPVFLQYCSSSIMLCGTVYYFSSIPMDYVECVSTMVFIIGTILQIFMCCMSAHQLTLQFENLNEGMYNTDWFNLSVNARKSMIIIVLKTFQPVVFMSGYIVTLSIESFKSVSLFIYKKCHEVILLYLQCSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MPW8</accession>
    <name>A0A8J2MPW8_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Similar to Rgl1: Ral guanine nucleotide dissociation stimulator-like 1 (Mus musculus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HICCMSTLAB_LOCUS11055</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5102518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MPW8"/>
    <dbReference type="OrthoDB" id="26687at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007265">
        <property type="term" value="P:Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00153">
        <property type="entry name" value="RA_RalGDS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00155">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06224">
        <property type="entry name" value="REM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.840.10">
        <property type="entry name" value="Ras guanine-nucleotide exchange factors catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.870.10">
        <property type="entry name" value="Son of sevenless (SoS) protein Chain: S domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000159">
        <property type="entry name" value="RA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008937">
        <property type="entry name" value="Ras-like_GEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000651">
        <property type="entry name" value="Ras-like_Gua-exchang_fac_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019804">
        <property type="entry name" value="Ras_G-nucl-exch_fac_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023578">
        <property type="entry name" value="Ras_GEF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001895">
        <property type="entry name" value="RASGEF_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036964">
        <property type="entry name" value="RASGEF_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113">
        <property type="entry name" value="GUANINE NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113:SF312">
        <property type="entry name" value="RAL GUANINE NUCLEOTIDE DISSOCIATION STIMULATOR-LIKE, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00788">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00617">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00618">
        <property type="entry name" value="RasGEF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00314">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00147">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00229">
        <property type="entry name" value="RasGEFN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48366">
        <property type="entry name" value="Ras GEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50200">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00720">
        <property type="entry name" value="RASGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50009">
        <property type="entry name" value="RASGEF_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50212">
        <property type="entry name" value="RASGEF_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-terminal Ras-GEF" evidence="6">
        <location>
            <begin position="64"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-GEF" evidence="4">
        <location>
            <begin position="167"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-associating" evidence="5">
        <location>
            <begin position="576"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="432"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="480"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="663"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="442"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="491"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="663"/>
            <end position="676"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAG5102518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="683" mass="77276" checksum="3D419D18813E5A48" modified="2022-05-25" version="1">MMDRVSRYHKGLLLVPFLFLLLHLFSIPLIRLLSSIKSRVNSVHYYCALACLLHGKIMKLSGAFIRFLKAGTVQKLVESLANDDGELESTYINVFLATYRAFTTPREVLELLLSRYDDLNSDGDKSYGQTEEQHRKTLIQALHVWLDAYPDSFTSDNWSGYKFPEVPHRHFAEQLTRMDADVFKKLIAHQCLGAVWSRRDKSRSHDAATVLATVNQFNAVSLRVISTILIDPTIKSQERARIIETWIDIAQELRILKNFSSLKAIVSGLQSNPVYRLEKCWQSMPRDKHEIFIELERIFSEENNAWTQRELLIKEGTAKFADTAGRSDRHLQKIFQKQNTQAGKISYGTIPYLGTFLTDLTMIDTAIPDTIAEGLINFDKRRKEFEVLARIRLLQGAANAYNFTKDPLFDRWFHSIIIVDDREAYKLSCQIEPPPGGNTLQNRKKKTHQCHQGHRKNDSLASTSSSSSSQFYCDLDSLPSSPHNSLDRRTSPSQMSSSSSSSSLPSLDVSLGSGIGNSNINSNKNDSNNNNNNNNNNNNNNNNLGQLLSTTNNGRSSTPNLISLSSPSNSHSNTPDFYIIKVTIETDNVETDGVIMYKSIMLSNNERTPQVIRNAMLKLCIEGNPDQYTLAQILPDREMVLPNSANVYYAVNTQHNLNFILRPRKDLNDSKTESPKGKSNTKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MQL5</accession>
    <name>A0A8J2MQL5_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Similar to SPBC4F6.14: Uncharacterized RNA-binding protein C4F6.14 (Schizosaccharomyces pombe (Strain 972 / ATCC 24843))</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HICCMSTLAB_LOCUS8178</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5096374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MQL5"/>
    <dbReference type="OrthoDB" id="3945418at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12414">
        <property type="entry name" value="RRM2_RBM28_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12416">
        <property type="entry name" value="RRM4_RBM28_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000182">
        <property type="entry name" value="RNA-binding motif protein 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051945">
        <property type="entry name" value="RRM_MRD1_RNA_proc_ribogen"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48039">
        <property type="entry name" value="RNA-BINDING MOTIF PROTEIN 14B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48039:SF5">
        <property type="entry name" value="RNA-BINDING PROTEIN 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="7">
        <location>
            <begin position="48"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="7">
        <location>
            <begin position="196"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="7">
        <location>
            <begin position="265"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="7">
        <location>
            <begin position="405"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="133"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="506"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="581"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="133"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="155"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="506"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="598"/>
            <end position="612"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG5096374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="650" mass="75140" checksum="F88BE76C7D30D914" modified="2022-05-25" version="1">MKAMKKMDGPRKDRKQLSWAYRNKKKQGKVVKKESNNNDNVQVQNKKARIIVRNLSFKVTEDDIRKFYSPFGEIEQIDLLRKPDGKLVGCGFIQFKRLEDASKAIFKTNKKEFLGRPITSTWAIAKSKFVEKLQQNEKDQETPRTTEEPSADNDDFIKLDDSDKSKSSFKKPIKVKKKLTSEERKELKLKQRKKRSRIVVRNLSFKADENTIKEHFQQYGTIEEINMLKKDEKFTGCAFIQFDHVQSARKAVFHANMKPICDRPNVPFSVKNDELRKCMEQFGPVYYALVCIDSLTEHSKGTAFVKFVNAEDAEKCLSAGTELRLHNQVLDPHRALDRNELANGNSSKSRKIKDSRNLYLVKEGVIMAGSPAAQGVSAADMKKRLELEQWKSQMLRNLTMFVSRVRLIVHNLPPNLEDSTLKTIFLKHAGPKAFITEARIMRHLNNKNSEMNGTSKGFAFVAFTKHEDALRALRMINNNPNIFSKSKRPIVAFSIESKAILNAKERRIKSSREKNPLWKDNKRDYYDKSSDPPVKRLKNNNEEKFEDEDAQKFSGINSKPGAPLKLRAKFKLKEQALRHREQLKTEKKNAKSKRRIKEIKTSESLSRKEIKPKVGQKKPTIDEANLSKLINNYKDKLTSIPQNKSKWYDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MRA8</accession>
    <name>A0A8J2MRA8_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Similar to Prkag2: 5'-AMP-activated protein kinase subunit gamma-2 (Mus musculus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HICCMSTLAB_LOCUS12023</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subunit">
        <text evidence="4">AMPK is a heterotrimer of an alpha catalytic subunit (PRKAA1 or PRKAA2), a beta (PRKAB1 or PRKAB2) and a gamma non-catalytic subunits (PRKAG1, PRKAG2 or PRKAG3). Interacts with FNIP1 and FNIP2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the 5'-AMP-activated protein kinase gamma subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5104480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="449052at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031588">
        <property type="term" value="C:nucleotide-activated protein kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016208">
        <property type="term" value="F:AMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019887">
        <property type="term" value="F:protein kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04618">
        <property type="entry name" value="CBS_euAMPK_gamma-like_repeat1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04641">
        <property type="entry name" value="CBS_euAMPK_gamma-like_repeat2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="entry name" value="CBS-domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050511">
        <property type="entry name" value="AMPK_gamma/SDS23_families"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13780">
        <property type="entry name" value="AMP-ACTIVATED PROTEIN KINASE, GAMMA REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13780:SF35">
        <property type="entry name" value="LD22662P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0129">CBS domain</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CBS" evidence="7">
        <location>
            <begin position="1088"/>
            <end position="1148"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="7">
        <location>
            <begin position="1169"/>
            <end position="1227"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="7">
        <location>
            <begin position="1242"/>
            <end position="1304"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="7">
        <location>
            <begin position="1316"/>
            <end position="1375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="255"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="450"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="603"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="711"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="757"/>
            <end position="884"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="10"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="43"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="66"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="87"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="110"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="152"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="170"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="183"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="200"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="283"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="308"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="348"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="460"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="519"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="539"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="554"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="605"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="631"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="711"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="757"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="772"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="826"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="845"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="865"/>
            <end position="879"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00025878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG5104480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="1395" mass="156457" checksum="10C17D75A680583F" modified="2022-05-25" version="1">MRMEGIGNEKTNETDGCFNKKEALLERDEASEEETKTNKKKEDDDDDDDDDDDDDDDDDDDDDINNALNDSENRVNAMSSTNGNQLEKLEKLEKLEKQTSREEDPEEDEGKGSDEEQESKEKTEVEDNKRDNNEESSTSSTSTSDDESETTSEDKTDPSGKPEEASLLSPPSPLSPPSPPAADSDKPQEKTEEPAKNDDTTDDSDIDDDLVSTINYNTITSLAALKDMLQCTGEDSDNVDSFFHHYFLSHVNRLPSRNQTHSPYPWGRRLSECREEDEDETEEGKTNEGDKSNDKKVTNQESQDKSESVTSKVSSPSSSEKSSSEKIDQKSNTTSSVSESRPRPPPTASTGSRFTTTIVTSPTANKPLLRRRHTSGPTMTFPATDPPNYCNSMVFSRTSPLPSPHLDKRFFDSSLIEMKSQASSSSTLDYDSAEEIWVKRVDFLQERKRKELRLSQPLPVKKDEKEEEKKIDVANEEVEGLRPRAGTWSPNSDKKKKVPKPAVSSAPNSGRSTPLPHHSIAVNTSASVSAVALKKHPTATRSASTSRSNSRSNSVDRRSEELSPTKRNTFLGNFRSRSKSDSSKRKSSIIATVRAQLQLYKAGGKESGSGGSGGVGGGGESSTGSSTSDVNPERESRRSRKDERRASADCMRNPVSRVIDLLRRSKSPNTVEDRRRGISESSFASVIAIIISINFTFHIRITIRSSFSSNLLSHHNSSSSSSNESKGSQDKCSISEAKRYYQQDNSRALQELLNNQKHTESQKININDRQQSRGSVSSNYSYGSSYGSSHGSSSSNYGSGNPLHSAGNNHNSVYHTIHGSGYTHHSPLQTLYQGTQRNQNHRHSISSSAGTPISLSPTNESTEKRSHHHHHHHHHHHHHSIQEMIRHFGRRLGHIRRQSECQETPKKNENDFRNRSQSLDGALKIASPRLADDCETTYRIYESILKQACSKSNLTQQQNQKLAELCNMLFKRQTSEPTGGSSAPVNITKLSPNAIEAPSPTSSPTSSNLFTNWYSKITANVKKRQPFSPKTLLKKALWLIHSQKVNQNQIWRNKKALLYCELFGFAEKDETQIYVKFFKFHKCYDLIPTSAKLVIFDTKLAVKKAFFALVYNGVRAAPLWDSAKQQFVGMLTITDFIKILQKYYTSPTVTMYQLEEHELNTWRDVLHKEIHPLVTIGPDASMYDAIKSLIQNRIHRLPVIDPDTDNVLYILTHKRILKFLFLYIHELPRPSFVDKTIEELRIGTYDNIATATEETSIILALKKFVERRVSALPILDSEGKLVNIYSKFDVINLAAMKTYDNLDVSLKEATQHRSDWFEGVHKCKLDDTLFIVMEKIVKAEVHRLVVTDENEKVIGIISLSDILLYLVLRPCGTQSTLVEQSQESARREVAVSSGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MSM4</accession>
    <name>A0A8J2MSM4_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Similar to spir: Protein spire (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">HICCMSTLAB_LOCUS12914</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
            <orientation evidence="3">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the spire family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5107779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MSM4"/>
    <dbReference type="OrthoDB" id="10043757at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030659">
        <property type="term" value="C:cytoplasmic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051639">
        <property type="term" value="P:actin filament network formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030041">
        <property type="term" value="P:actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045010">
        <property type="term" value="P:actin nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036089">
        <property type="term" value="P:cleavage furrow formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051295">
        <property type="term" value="P:establishment of meiotic spindle localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048193">
        <property type="term" value="P:Golgi vesicle transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040038">
        <property type="term" value="P:polar body extrusion after meiotic divisions"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd22068">
        <property type="entry name" value="WH2_DmSpire_r3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011019">
        <property type="entry name" value="KIND_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029901">
        <property type="entry name" value="Spire"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21345:SF3">
        <property type="entry name" value="PROTEIN SPIRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21345">
        <property type="entry name" value="SPIRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16474">
        <property type="entry name" value="KIND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00750">
        <property type="entry name" value="KIND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51377">
        <property type="entry name" value="KIND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="12" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="KIND" evidence="15">
        <location>
            <begin position="28"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="144"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="420"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="553"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="677"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="147"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="420"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="465"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="493"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="713"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="740"/>
            <end position="750"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CAG5107779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="829" mass="93653" checksum="4F28340B17BC94B5" modified="2022-05-25" version="1">MDVKKIKKPVPKPRTRRLNCKLNCDDTLNLEDTLLAFNGPIGQEQAWAVCHQTAKYLATLGPNNFQELTHLNQILLHKEGYVLLDLPTNVSSHTLPSSERKVIFSLGILIYNALDFRLDQKEERRLSLDLKDLINLMTSCDEEYELEERHETDDEGIGRDSEAEMDDPHESSSYISNSDYYSLKNIVQVCIKHVQGTEEQADVHYRAVIRTFVHEALELTQFLEQVSVERFQDNPKRFSKHLEPKPAVASCQQLDTLGYDDWARFWVQVIGELRRGIKLKKVEENLGKRGRAHSKGRGTEFELTPYEILMNDIRERRYNLKKTPAPSPRVTKDARAIVLEFIRSRPPLKKASERQLPPRRKQSTMRELLMESIKKPPRPLRSFRERQLNEKKVIHNHDCHPVDLLGGEPRRIVLGEVPPAQAEQVQEQESAQDVAAQWRHSEGQGSHPVPKPRQRFSKPTEAKARNRKCRRRIRGSATQCPSRRASARKHTSRCSTKPSVAFSGTCSVPHSRPQSRQRVGVIGNDIRMSLSPSPNVSPSISPRTRERILMKSHTTVEPESDHHTQSDNERKPSLGDMFLDERLSLTLEEIVHIRSVLTKAELESLPVEGRVKEDVEKRRVCFLCLKTRFGILGPWGQRCRLCERTVCVKCYSKMRIPTEHFAHVPVVLLSPGLLLSPSTSEPDSTRSPWPRPGGAVGSAPASPAHRRHDPALNNGTPLSTPNPGTPADNLTPGSTPTSLGRRDDLLDRSRYPKVGGSPSRMSNSAIGSLGPGIGNEPLVAERLRGVSMVVCHDCRIMVIQIIKSSRSTRATIRNNVISRLTLNLSPAYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MT11</accession>
    <name>A0A8J2MT11_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Similar to CG14683: Probable methyltransferase-like protein 15 homolog (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HICCMSTLAB_LOCUS13083</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily. RsmH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5108129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MT11"/>
    <dbReference type="OrthoDB" id="16290at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071424">
        <property type="term" value="F:rRNA (cytosine-N4-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070475">
        <property type="term" value="P:rRNA base methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.170">
        <property type="entry name" value="Putative methyltransferase TM0872, insert domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01007">
        <property type="entry name" value="16SrRNA_methyltr_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002903">
        <property type="entry name" value="RsmH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023397">
        <property type="entry name" value="SAM-dep_MeTrfase_MraW_recog"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00006">
        <property type="entry name" value="16S rRNA (cytosine(1402)-N(4))-methyltransferase RsmH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11265:SF0">
        <property type="entry name" value="12S RRNA N4-METHYLCYTIDINE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11265">
        <property type="entry name" value="S-ADENOSYL-METHYLTRANSFERASE MRAW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01795">
        <property type="entry name" value="Methyltransf_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20180">
        <property type="entry name" value="UQCC2_CBP6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81799">
        <property type="entry name" value="Putative methyltransferase TM0872, insert domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAG5108129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="466" mass="53386" checksum="8D4F2C7A5B045856" modified="2022-05-25" version="1">MAGTYKNYMKLLEAWPADKSKPGRDLGQYIRDRIKLEFSTNKVRSQAEKEECDRNYTSLQRISSNHYAKLYPRKLNSSGTGLSYEQCNCALSPEVLESYQRQKQMNQLILNKLPLKLGVRYFTQVAAELSEKVYTRPHTPVMVNEVIKYLKPSAGETFIDMTFGAGGHSTRIIESAPNIKIYALDRDPVAHNYAKIMAEKYPGQIIPLLGRFSELPGLLKEQRVLPNSIDGFIFDFGCSSMQFDIAERGFALSKDGPLDMRMDGFRCPDKPTAADVLERCTEQDLARIIKYYGEEKQYKKIARALIEARYMFKSLKTTKELARLVESVLDKDFRTDRLGRFAHSATKVFQALRIFVNNELNEINYAILIAEKYLKINGRLITISFHSLEDTVVKRHLSGNITDNAANISSMRFQNYGKTFSHSQVVDMTESPWRMLHKHVILPSDEEINENPRSRSAKFRAIAKVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MTE0</accession>
    <name>A0A8J2MTE0_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Similar to HLCS: Biotin--protein ligase (Homo sapiens)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HICCMSTLAB_LOCUS7290</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the biotin--protein ligase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5093964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MTE0"/>
    <dbReference type="OrthoDB" id="10250105at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004077">
        <property type="term" value="F:biotin--[biotin carboxyl-carrier protein] ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004408">
        <property type="entry name" value="Biotin_CoA_COase_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003142">
        <property type="entry name" value="BPL_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004143">
        <property type="entry name" value="BPL_LPL_catalytic"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00121">
        <property type="entry name" value="birA_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12835">
        <property type="entry name" value="BIOTIN PROTEIN LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12835:SF5">
        <property type="entry name" value="BIOTIN--PROTEIN LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02237">
        <property type="entry name" value="BPL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03099">
        <property type="entry name" value="BPL_LplA_LipB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51733">
        <property type="entry name" value="BPL_LPL_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0436">Ligase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035315811" evidence="4">
        <location>
            <begin position="16"/>
            <end position="1025"/>
        </location>
    </feature>
    <feature type="domain" description="BPL/LPL catalytic" evidence="5">
        <location>
            <begin position="753"/>
            <end position="948"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="303"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="343"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="359"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAG5093964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="1025" mass="115140" checksum="FF1939832BC60765" modified="2022-05-25" version="1">MLLTFIYMILTWARARRLTPLRTYLVRVLNSSNSDNLPNYVKPSLMCHIKSSDSSKSDVNSKQTDSETSHDLLTSHLCSNKNTAKLFKLIWSVGDNKLCIIIPQQKIDVSEWLVYPLGKMNFPLSVNNCNQTKLADDSKVHLLIEADINNFNPSAFTRTIKLEDYGLLLSWTADKLFAAIMETDIDHMSKLSIALMESFCFINNGLLLTRIESVEVSGKPCSYNINQSSLWNKKLVGKAQWKTHMETLKLFSSTARRVSQQKEPFEVDTLPGIIVSPGTRSLSLQIPTVLEINHQHDTLEAQEFKTEDSTSVPKTPPPTPASLSMMDRGDSVRRSLQMSSNELNTTLSRNSETPDHQLSVANSNYSSTQNIDEDEPKEDKTKSRASSDANLCERILPKTFKGDPFDTSYTNRAEKYSEKRKFQNYPEPGKPPNVLIYADSTLASDNIERVLKQTLNKEKYIIYKLTPEDARRDVWKDQANLVVVCGNVDSEIASQLVNYIVEGGKLLALCSDALHTLLPSFKTAEVREHELVRFSYGKWKNVQMMHHIFCYQASPIKSRFSQDHEDVKTTPVTPASSTVKDKQGKTHTFQVRVLGAEETWHTPSIVLADLPTTGGKALFSQIHLEADPSQYEMEEAKYNALKASNPARLEILSDLLGSHLGVDVKPVASGDVAFSPGFFLGRHEARIRKFINYFSVLKLEMLERLKDKMEANDIFKTNKTKLQFCNNTNKLVPPSSSILPIMLHTCPDNFSTIEYFENLKTKDFGRLVIYADIMTSSMDVVAGCKLHHGLAVIPRQQTQGQGRNKNVWLSTKGCLMFTLQLHIPLNSYLGNHLAILQHIVVVAVIAAVKSIPGYEEIDLNIKWPNDIYLGDKVKLGGLIVPTLLESSEAICNIGSLGVNLSNSTPTSSINDAIKKYNEKKGTNLAPLGYEKFLALIFNQLESLINSIQNDNVNHFYQFYYDYWLHTDTQVSFESPDGTIREVKILGIDSNGYLQVQSLDGKVFSLQPDGNSFDIFKGLIAPSLSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MUH4</accession>
    <name>A0A8J2MUH4_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS8167</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5096352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MUH4"/>
    <dbReference type="OrthoDB" id="7694872at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="224"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="232"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5096352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="828" mass="94512" checksum="C8C22595259363F3" modified="2022-05-25" version="1">MSSSLDISIDTSEILDIAEKLIDDVEKKIAQVNYGIKNFRLDDSSYADESVLYIREVVNAKFKELNRDILSLDDNYCSDGNEIEYQHCHCEQRNNNTMEMPRVFTLNNNNNKQIITNEEQKSGSESKPQLKVKIKKGILNKTDSIKSQSSQLSVISSLKLDLLSNDNNIIKRNNSNISELKNDSCEQKQKKESSVDIAVQTSIQETPHKKPASLDKSQDLLTEKNISSDSISNDKIKPETINPDDDKRQHLCKTNFQQRHINENTKKSNGSFIEFMCRIVELETNNVNEMNTDDLIEENRHQLSYNKTTEDEIINDDFDFNKINLYSPKFEHVDKILNKFDEKMKTFSENANKLVNIFSQIVVCNNNSNINLKITKSDTREKNFDGVELSFKAQTRNLSPETTITSESLKPAERFSTPLNNYSVNIDAKNISNDIEELPTPIIKPDINNDSKVFITRNKLSLSASTIENCDKVTAHDKSEIELHLSETLQKIQKQINEKRHSDECHDFSYNDNVKKFDCQQETEVNYKVLENSFNITNQKICGNKKKQFETTKSSFSNEKTLSKSVKLRQSSKNTPLEINQNVEPDYVEVNLVVDSSKDDLRDRTSFDVSGIYSESFETASFSENENTLDELKNSNDDKIENFELNKENHGEFEPCLSIDCEKNNTNLYNVIEELKDKSQTGEKIIPISDNKKNSIDIANSLNLSIQSSTKQSEDKKQTSSLSLKSFQLLEKIPSVEILQEKKEKNSSGEYSEGELPLPFSLGEVRVNGTPDSQENENSNYYQNLTDQIHNILNSSLKSLGEILNSNGDSTSSKEKKFILLEHLIAKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MV27</accession>
    <name>A0A8J2MV27_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Similar to Perlucin (Haliotis laevigata)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HICCMSTLAB_LOCUS8533</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5097083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MV27"/>
    <dbReference type="OrthoDB" id="6133475at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00037">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050828">
        <property type="entry name" value="C-type_lectin/matrix_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45710">
        <property type="entry name" value="C-TYPE LECTIN DOMAIN-CONTAINING PROTEIN 180"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45710:SF26">
        <property type="entry name" value="RH26557P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035292556" evidence="2">
        <location>
            <begin position="21"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="3">
        <location>
            <begin position="58"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="199"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="209"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG5097083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="292" mass="34367" checksum="CB9585783EA776ED" modified="2022-05-25" version="1">MWKCWILLLCSTGLSLSSSAVGPQSVSINLPENNHVKNEVKKELSVRRFACPIGFFRLKRNCYYLSAGMAPWREAHFHCKDRNSTLAILDKKGKNRILRKYLMGDQFTKLERWIGGIYNWQQMTWEWGVSGEKVVFQNFHNLNQSNSKAYAWHCIVLDPAIKYKWSPRSCVKKKHYICQLKLKLNFHVLGHRRKKIKDNNLVEQNQITKPKRKERKGSRSRHPRPADRTRHQLNRIRQRDDTPKITQRIPQGYEHGAFLRDGSIDTNPQFLADSQYHNSFNDIAHEEVLIKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MWV5</accession>
    <name>A0A8J2MWV5_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Eukaryotic peptide chain release factor GTP-binding subunit</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">ERF-3</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">ERF2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Polypeptide release factor 3</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Translation release factor 3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">HICCMSTLAB_LOCUS10122</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5101049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MWV5"/>
    <dbReference type="OrthoDB" id="342024at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003747">
        <property type="term" value="F:translation release factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000288">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000184">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01883">
        <property type="entry name" value="EF1_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03704">
        <property type="entry name" value="eRF3_C_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04089">
        <property type="entry name" value="eRF3_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000017">
        <property type="entry name" value="Eukaryotic peptide chain release factor GTP-binding subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000024">
        <property type="entry name" value="Eukaryotic peptide chain release factor GTP-binding subunit ERF3A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000270">
        <property type="entry name" value="Eukaryotic peptide chain release factor GTP-binding subunit ERF3A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054696">
        <property type="entry name" value="GTP-eEF1A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009818">
        <property type="entry name" value="PAM2_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003285">
        <property type="entry name" value="Sup35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050100">
        <property type="entry name" value="TRAFAC_GTPase_members"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009001">
        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23115">
        <property type="entry name" value="TRANSLATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22594">
        <property type="entry name" value="GTP-eEF1A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07145">
        <property type="entry name" value="PAM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01343">
        <property type="entry name" value="YEASTERF"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50465">
        <property type="entry name" value="EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0866">Nonsense-mediated mRNA decay</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Tr-type G" evidence="18">
        <location>
            <begin position="205"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="54"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="10"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="54"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="88"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="17">
        <location>
            <begin position="112"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00029585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00030210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00030845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00031881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00049117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="CAG5101049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="631" mass="68752" checksum="1A39B42955CF07D9" modified="2022-05-25" version="1">MANSVAPDSWEQQADSADTTADNTFIEGKFSTLNVNAAEFVPSFCINSLPPSNVTSNETTSNASTPVNVDNTVATPEAATSGGDTPVDESTSISETNVATTTFVPPETHHAPPVPALPPDPVGNRVEEPPAGGGPPPPSNVIDPEASNSSPEHQPADSWEEAAVDGDPLITPENEEADIEEDEEMIVKITKKKPVKVAEDTKSKKEHVNVVFIGHVDAGKSTIGGQIMALTGMVDKRTLEKYEREAKERSRETWYLSWALDTNQEEREKGKTVEVGRAYFETERKHFTILDAPGHKSFVPNMIGGAAQADLAVLVISARKGEFETGFDRGGQTREHAMLAKTAGVKHLVVLVNKMDDPTVEWDEGRYNECRDKILPYLRKLGFNPAKDLTFMPASGQLGIGLKDPIPESLCSWYSGPPFIPFIDSLPSLNRKSNGPFIMPIVDKYKDMGTVVMGKVEAGESRKGQALLVMPNRTAVIVDQLWSDDEEVTSVGPGENVKIKLKGIEEEDVSPGFVLCDSNNPITTGKVFDAQVVILEHKSIICAGYSAVMHIHCAAEEVTVKTLLCLVDKKTGDKSKTRPRFVKQDQVAIMRIECAGVICLEKFKLFPQMGRFTLRDENKTIAIGKVLKVVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MYA7</accession>
    <name>A0A8J2MYA7_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS12672</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5107284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MYA7"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5107284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="111" mass="12258" checksum="29FAE1E3B070503F" modified="2022-05-25" version="1">MANQQWRGNDGGDDDDDDDDDGGCCCCCCCVVESTVGTSGFERISLRVALWTPCISFAITAIVFYEKRLENGVTELSYRRNSRGRARAARQVKRSNEPTDQSAHGAIAFLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MZD3</accession>
    <name>A0A8J2MZD3_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS13901</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5109265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MZD3"/>
    <dbReference type="OrthoDB" id="7635152at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="203"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5109265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="253" mass="27876" checksum="237B992F9262E7AA" modified="2022-05-25" version="1">MLLSHESQIKFSAWRVSDDVSRANSQLRQWFPEPVSSPTKVQAEESQKDGSALGSEEYVGTAIITVGSAISLLLKDPEEEVDKLKLLEYLSDTGKLLAETFHQHSAARKAYMTPVMKKSVKTLVDSIHSEECLDGDKLADQIKEAKTIERKLKRPVFSIQTDGPSQPSEIFALQVENSEPQKSDIYSGKEPGLHGIVEEVTEPRGQDGGLTWETGAGSRLGESQQSPRWNNAKDLPRFVKSPGQDTLGGLNKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-24" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>B9W488</accession>
    <name>B9W488_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Cc_pif3</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">Putative per os infectivity factor PIF-3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">pif-3</name>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS5454</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2009" name="Science" volume="323" first="926" last="930">
            <title>Polydnaviruses of Braconid Wasps Derive from an Ancestral Nudivirus.</title>
            <authorList>
                <person name="Bezier A."/>
                <person name="Annaheim M."/>
                <person name="Herbiniere J."/>
                <person name="Wetterwald C."/>
                <person name="Gyapay G."/>
                <person name="Bernard-Samain S."/>
                <person name="Wincker P."/>
                <person name="Roditi I."/>
                <person name="Heller M."/>
                <person name="Belgahzi M."/>
                <person name="Pfister-Wilhem R."/>
                <person name="Periquet G."/>
                <person name="Dupuy C."/>
                <person name="Huguet E."/>
                <person name="Volkoff A.N."/>
                <person name="Lanzrein B."/>
                <person name="Drezen J.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <tissue evidence="2">Ovary</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5089999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FM201563">
        <property type="protein sequence ID" value="CAR31576.4"/>
        <property type="molecule type" value="mRNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FM212911">
        <property type="protein sequence ID" value="CAR82247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B9W488"/>
    <dbReference type="OrthoDB" id="7671158at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007703">
        <property type="entry name" value="PIF3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05006">
        <property type="entry name" value="PIF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5089999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAR31576.4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="217" mass="24812" checksum="238095430085C42F" modified="2009-03-24" version="1">MTHIFCTIFVVSIIFMCLIQLKRMSAIEQLKDSKKLFTTLNINDFKIQNRHIDDCNLEKQYCFDQNDCFNRCQMSNKGMFECIAGVCKLKVDLATLNDVSKCNLEEGMAPFLIGVPELATVEAICKPVDLGIVYIDENTKKVENKMCAGRDVKANDKVDYMANWPNPKDCKCGKDKSPIIIPATENVRQYVQCIKNDDALKWVYDETKLAYHPKENS</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-10-16" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>S6CVR8</accession>
    <name>S6CVR8_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cc_serrich.7_32.10b</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">ser-rich7</name>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS6199</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Philos. Trans. R. Soc. Lond., B, Biol. Sci." volume="368" first="20130047" last="20130047">
            <title>Functional endogenous viral elements in the genome of the parasitoid wasp Cotesia congregata: insights into the evolutionary dynamics of bracoviruses.</title>
            <authorList>
                <person name="Bezier A."/>
                <person name="Louis F."/>
                <person name="Jancek S."/>
                <person name="Periquet G."/>
                <person name="Theze J."/>
                <person name="Gyapay G."/>
                <person name="Musset K."/>
                <person name="Lesobre J."/>
                <person name="Lenoble P."/>
                <person name="Dupuy C."/>
                <person name="Gundersen-Rindal D."/>
                <person name="Herniou E.A.Drezen.J.M."/>
            </authorList>
            <dbReference type="PubMed" id="23938757"/>
            <dbReference type="DOI" id="10.1098/rstb.2013.0047"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5092530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="HF586473">
        <property type="protein sequence ID" value="CCQ71252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S6CVR8"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="43"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5092530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCQ71252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="147" mass="16382" checksum="D980B687061B3AF9" modified="2013-10-16" version="1">MADRKISRCRLEKSKEASGNVVSRFFRRLSPTKSYRGNETPGSSSSSTIQASRSRKKDSSAVKNSSGKEDQHSKKLTKSILNQPEFISSSNSSLSQPTLPWISPALSYHSLNQDKQATELKLLSQLHSNFEETTNILGNDISRLDHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2023-09-13" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>S6CWI6</accession>
    <name>S6CWI6_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Cc_single_3.7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">CcBV_3.7</name>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS12808</name>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS6144</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Philos. Trans. R. Soc. Lond., B, Biol. Sci." volume="368" first="20130047" last="20130047">
            <title>Functional endogenous viral elements in the genome of the parasitoid wasp Cotesia congregata: insights into the evolutionary dynamics of bracoviruses.</title>
            <authorList>
                <person name="Bezier A."/>
                <person name="Louis F."/>
                <person name="Jancek S."/>
                <person name="Periquet G."/>
                <person name="Theze J."/>
                <person name="Gyapay G."/>
                <person name="Musset K."/>
                <person name="Lesobre J."/>
                <person name="Lenoble P."/>
                <person name="Dupuy C."/>
                <person name="Gundersen-Rindal D."/>
                <person name="Herniou E.A.Drezen.J.M."/>
            </authorList>
            <dbReference type="PubMed" id="23938757"/>
            <dbReference type="DOI" id="10.1098/rstb.2013.0047"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5092450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5107567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="HF586473">
        <property type="protein sequence ID" value="CCQ71198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S6CWI6"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5092450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5107567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCQ71198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="97" mass="10721" checksum="1BB37E4FF4EF72FD" modified="2016-04-13" version="1">MRNAGRVTKTERVTVGTRLCIGATRMELRRKQASIEEYRSDEAPSGVNTREAWIPIDAAVPLFSNTTINIDDSWLVSTAGAEVTKNCREGPLTVIRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2023-09-13" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>S6D2T2</accession>
    <name>S6D2T2_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cc_bv5.4_23.3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">bv5-4</name>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS6069</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Philos. Trans. R. Soc. Lond., B, Biol. Sci." volume="368" first="20130047" last="20130047">
            <title>Functional endogenous viral elements in the genome of the parasitoid wasp Cotesia congregata: insights into the evolutionary dynamics of bracoviruses.</title>
            <authorList>
                <person name="Bezier A."/>
                <person name="Louis F."/>
                <person name="Jancek S."/>
                <person name="Periquet G."/>
                <person name="Theze J."/>
                <person name="Gyapay G."/>
                <person name="Musset K."/>
                <person name="Lesobre J."/>
                <person name="Lenoble P."/>
                <person name="Dupuy C."/>
                <person name="Gundersen-Rindal D."/>
                <person name="Herniou E.A.Drezen.J.M."/>
            </authorList>
            <dbReference type="PubMed" id="23938757"/>
            <dbReference type="DOI" id="10.1098/rstb.2013.0047"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5092343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="HF586472">
        <property type="protein sequence ID" value="CCQ71093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S6D2T2"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036441351" evidence="1">
        <location>
            <begin position="20"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5092343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCQ71093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="97" mass="10729" checksum="A0A0BCD340C719F5" modified="2016-04-13" version="1">MVYTKTSIFLLFFIIGTSVFPNDSSIGLASAKPQNSLYTWNQLPLHDIIDHSKRLASQPPRNNRGPIVSYASITNSEDNTIVNENIRGSVTFDTSSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2E0C4</accession>
    <name>A0A8J2E0C4_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Similar to nrxn1a: Neurexin-1a (Danio rerio)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HICCMSTLAB_LOCUS109</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell projection</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030000649">
        <property type="protein sequence ID" value="CAG5071960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2E0C4"/>
    <dbReference type="OrthoDB" id="6108017at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042995">
        <property type="term" value="C:cell projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016459">
        <property type="term" value="C:myosin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000146">
        <property type="term" value="F:microfilament motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030832">
        <property type="term" value="P:regulation of actin filament length"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052409">
        <property type="entry name" value="Myosin-III_kinase_activity"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001609">
        <property type="entry name" value="Myosin_head_motor_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46256">
        <property type="entry name" value="AGAP011099-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46256:SF2">
        <property type="entry name" value="NEITHER INACTIVATION NOR AFTERPOTENTIAL PROTEIN C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00063">
        <property type="entry name" value="Myosin_head"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51456">
        <property type="entry name" value="MYOSIN_MOTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="6 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0966">Cell projection</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8 11" id="KW-0505">Motor protein</keyword>
    <keyword evidence="7 11" id="KW-0518">Myosin</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Myosin motor" evidence="12">
        <location>
            <begin position="1"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="72"/>
            <end position="79"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAG5071960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="111" mass="13159" checksum="2CFCCC95462BDCCA" modified="2022-05-25" version="1">MFVPNSLWMENTKKRNSLPVLQKITYESFLQFHEKYNFKSRSDNEPHIFSVADKAYQDVLHNEEPQHIIIAGESYSGKTFNVINLVNHFMYLGKVISRLICYFQDEMPCKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2E1J2</accession>
    <name>A0A8J2E1J2_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS835</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001114">
        <property type="protein sequence ID" value="CAG5074063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2E1J2"/>
    <dbReference type="OrthoDB" id="7694116at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="83"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5074063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="109" mass="13185" checksum="2D70022579B072F5" modified="2022-05-25" version="1">MFLDQYFRQTSKPSYLRELFQEDLSVRRSERLAAKKNNILFKFPNFSTTQYESSFVITVIRLWEELPEDIINSSSLEMFDYKLLLMFLSFVSLILKLYFIPYYMSLSFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2E8T9</accession>
    <name>A0A8J2E8T9_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HICCMSTLAB_LOCUS458</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001114">
        <property type="protein sequence ID" value="CAG5073515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2E8T9"/>
    <dbReference type="OrthoDB" id="7700054at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13920">
        <property type="entry name" value="zf-C3HC4_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="1 3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="4">
        <location>
            <begin position="242"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAG5073515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="293" mass="34522" checksum="D8EFF186E38DD2E5" modified="2022-05-25" version="1" fragment="single">GITALYIICSERSEKLYNSILNHLKEKKIFENLKVIKCHFDNLLIGEIEKVLPLIEIKGSLYSFVKLLSRNCIVKLLPDNKVDEAINLINSKVDEDDDKYEDLSAFTKFLKKCSKLIIKNKTYVGENVTDAIDYAEYHNIHMIQQLGSHNKLHSFLELLRFDIKRNEKLWNNTAPVTKKKNYDRITTTIMKEQDKFKHKKQTLEKFKEQLFQSNIIDLLMVQLPWPQYRNDDGKLSANDQECLYCFDEKACVKVVPCQHYIACLLCWISDYYTMGNKRCPYCRTHYEKVTIIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2E9X4</accession>
    <name>A0A8J2E9X4_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS215</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001070">
        <property type="protein sequence ID" value="CAG5073084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2E9X4"/>
    <dbReference type="OrthoDB" id="6509516at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579">
        <property type="entry name" value="F5/8 TYPE C DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579:SF1">
        <property type="entry name" value="F5_8 TYPE C DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5073084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="204" mass="23221" checksum="0B876C416A1C4222" modified="2022-05-25" version="1" fragment="single">MAKWKASEWESWLLFDSLPCLTGILKKECFDSYCLFVSSIFKLLSGKISEREILECELHLLQFVGECQQFYGKGVMTFNLHSMIHIPKSVRQSGPLCSSNTFIFENGIFNYKLEINAAHGVSQQIVSSTLKTNHVRNNIDNATESTTCRNYCKNLFLPQYLTNYSRISNGAMLTGAANEPNSRISFLVRDLNIEVIHSIQVFSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2ECK2</accession>
    <name>A0A8J2ECK2_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS1081</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001116">
        <property type="protein sequence ID" value="CAG5074848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2ECK2"/>
    <dbReference type="OrthoDB" id="10437990at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="164"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5074848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="208" mass="22874" checksum="746BABC30DAC4079" modified="2022-05-25" version="1">MLSAEEINQFNGTTIEIYKLINLTNAIEFAKYENKIWLQTISELEKRINEGLNKYNVPLVRTKHDPDVNGTSLGTVNRMVSGEINGNFFGFNNETVLGTLNGTVLAAADGTVLGTFNGVIVGIINRTTSENIDQMVLRTIDGTVLGTDNRTVIGHDKGLILRKPKRPDSWASEPENNGTGEEAVDENNNLIRVGFKAPGAHFEEKEVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2EF71</accession>
    <name>A0A8J2EF71_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Similar to aPKC: Atypical protein kinase C (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HICCMSTLAB_LOCUS313</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001114">
        <property type="protein sequence ID" value="CAG5073369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2EF71"/>
    <dbReference type="OrthoDB" id="63267at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017892">
        <property type="entry name" value="Pkinase_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00433">
        <property type="entry name" value="Pkinase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="7">
        <location>
            <begin position="6"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="21"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG5073369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="79" mass="9166" checksum="1F166AC4F422934E" modified="2022-05-25" version="1">MSVLILSQIICQLEQKQVTPPYKPRLDSDRDLANFPPEFTDEPVHLTPDDQRVIEEIDQSEFEGFEYVNPLLMSLEDCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2GZ51</accession>
    <name>A0A8J2GZ51_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PiggyBac transposable element-derived protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS26</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030000183">
        <property type="protein sequence ID" value="CAG5070698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2GZ51"/>
    <dbReference type="OrthoDB" id="8123139at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029526">
        <property type="entry name" value="PGBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46599">
        <property type="entry name" value="PIGGYBAC TRANSPOSABLE ELEMENT-DERIVED PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46599:SF3">
        <property type="entry name" value="PIGGYBAC TRANSPOSABLE ELEMENT-DERIVED PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13843">
        <property type="entry name" value="DDE_Tnp_1_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PiggyBac transposable element-derived protein" evidence="2">
        <location>
            <begin position="120"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5070698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="193" mass="21945" checksum="723598DC322F6BEA" modified="2022-05-25" version="1" fragment="single">MLTRSRARWSTTNERAIAEDPGDSDDSVYSDEEPEIGSSQLNNSSDDDRSDEDDDDHEYVQDANKNITSSTKIQSKQNFFSAKDKETKWFIEPLVGGKSKKKNVLTQAPGVKRLGRAAKTPLDAWKLFFTDEILESIVINTNQKLKKRQVKYKRRNECPLTNMEEIQALLGLLYLAGSLKLSHTQANDLWSMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2GZI8</accession>
    <name>A0A8J2GZI8_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS631</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001114">
        <property type="protein sequence ID" value="CAG5073841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2GZI8"/>
    <dbReference type="OrthoDB" id="3225452at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="146"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="288"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="411"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="32"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="295"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="417"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5073841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="449" mass="46588" checksum="CAC7710399F86CA5" modified="2022-05-25" version="1">MIRIILINHLKFYLHYRIVRNKAAEKAKHAHQQQQAQQQGQPGSGGSVSVIAHAPATAGGHPAATAPNAYSISGILGIPAHHQDPNGNSIKRKRTDDDENRDHLSDHAEDDLKRQRNNYNGDQLYSNLWSSKWNIKDEQNKLLNELGGAGGTGNSGTTGSGTTGGANGAGGGAGNNTSGYYEHSGFPGNAIATSAELYDSLGSISTMTQAQAPHLYTPPIGGTIGGTLTPLAPLTMQELKLSQTLDGTNMSPYHGTDRSLIRMLCYYACIESSGVAVSYVNVSGTGDHSPPVSLQDGNVTPTTPNAGGGDPGLTVLQSPVSQAQVASSIPPYSTMLPSFGHYATGGGDYAYSAAYSQYSSAPYTGYGYGAATSGLLNSTYYYCNGDTLASSQNSQHHQSCNGMADNSADVASRSPLAATRASSGASAASPTGSACTNKTDHASTDLYLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H2U0</accession>
    <name>A0A8J2H2U0_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Similar to Ptp10D: Tyrosine-protein phosphatase 10D (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HICCMSTLAB_LOCUS1690</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001116">
        <property type="protein sequence ID" value="CAG5075536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H2U0"/>
    <dbReference type="OrthoDB" id="5854685at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009653">
        <property type="term" value="P:anatomical structure morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048666">
        <property type="term" value="P:neuron development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00047">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000242">
        <property type="entry name" value="PTP_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050713">
        <property type="entry name" value="RTP_Phos/Ushers"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46957">
        <property type="entry name" value="CYTOKINE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46957:SF3">
        <property type="entry name" value="CYTOKINE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00102">
        <property type="entry name" value="Y_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00700">
        <property type="entry name" value="PRTYPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00194">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50055">
        <property type="entry name" value="TYR_PHOSPHATASE_PTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="650"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="12">
        <location>
            <begin position="60"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="12">
        <location>
            <begin position="267"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="10">
        <location>
            <begin position="718"/>
            <end position="901"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="11">
        <location>
            <begin position="818"/>
            <end position="892"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAG5075536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="951" mass="107476" checksum="8F135657B2910BD0" modified="2022-05-25" version="1">MKNVITYCHANLCEEANVTQTLYNATNLLPCTTYHFSVSLHGENGEFGSTNITGVTGFLKPSAPSSAWSLPQNDSLIIFWSKPIGASCVALYRITVCQDHPYNNAFKENTTTGYQIMFNNLQSCSIYNVIIVPIDQFGNDSSPYIFYSNKTLAPIPEIPMYLSSNPGKNEIAIAWQLDINEFNNCGNMKILTVCNYNKVLGLGYNGTNSSSFINITEEFIQRIITTTINSLSPHTEYECFSITSNDRKNSSKSETVLLKTSEDISTSPELSVFNNTDKKFSFIWKLPVYLPGHISKFEVNFTWYYKFHQPIWCSNFSGKSEYSIILNGSTSSLSYEKAYPFSSYQASIRAKTLAGWSNYSDSVSFATHPGAPGPVSNLTYIFKKVSDDATNLEASLSWGLPCFINAVKIEHFVVTGIGTRNNFPNHDLNATIMSQICIDDMCTVELQLKDEYTYYFSVAGKVKDVKPLGPAEEITLLYPAGVPSDPETEYLDQITIDPYKTRKTTYSATILLPLFLNTHGEIRCYAIIVAKAGFNYGNFSRNDLKAGEWPSIASWIESAQKGFTIPYQASKFCNDSHEPHVVDYGKLKAIKFQIGEDIETCPELSKIKVSYCNGPLNPDTWYDVRMRAFTDGGYRDSRIFQIKTNAELQVSLIIGSIVGILSVGVLITIFLLVKKCSVQTVLRRLLNSNMPGSPVPAPFNRRKFIIHCQQLADNPGKLSNEFQLLQTLSLDLQMPTNAGCLHANRKKNHDFSRVKLDIIDNDPNSDYINASFIKGFSNDEEYIACQAPKEETIYDFWRMVEQYNFKDWPDHDVPEDFDAMINFCQIMRRNINASRNLVVIHCSAGIGRTGTLIAIDIILQHLKDNRKLDVFGTVYRLRQQRINMVQRESQYTFIYNCIKQVLKNPHFSKSYKPPYGSQCVRPSYEDKSELKHSNVLTINQNESIELDTDTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H5T7</accession>
    <name>A0A8J2H5T7_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Similar to cut-1: Cuticlin-1 (Caenorhabditis elegans)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HICCMSTLAB_LOCUS2055</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001116">
        <property type="protein sequence ID" value="CAG5076074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H5T7"/>
    <dbReference type="OrthoDB" id="10062424at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.4100">
        <property type="entry name" value="Zona pellucida, ZP-C domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056953">
        <property type="entry name" value="CUT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055355">
        <property type="entry name" value="ZP-C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042235">
        <property type="entry name" value="ZP-C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001507">
        <property type="entry name" value="ZP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46560">
        <property type="entry name" value="CYPHER, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46560:SF4">
        <property type="entry name" value="DUSKY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25057">
        <property type="entry name" value="CUT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00100">
        <property type="entry name" value="Zona_pellucida"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00241">
        <property type="entry name" value="ZP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51034">
        <property type="entry name" value="ZP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035172483" evidence="4">
        <location>
            <begin position="19"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="477"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="domain" description="ZP" evidence="5">
        <location>
            <begin position="123"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="29"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="50"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAG5076074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="525" mass="57651" checksum="BF62D4E5BD73E802" modified="2022-05-25" version="1">MRLYSVILICLLFGGATPEEVEVVEAIPGEDSAARPEDASTDQLALESLNSNSNPPSNSASNSNRGTIGSNRHNVAYHGPPPPPPGKQPAEALDKVFTTGTGVSSDWPSTSPDMPKIVSLDVKCEKNLMKIFLGFDKPFYGIVFSKGHYSNVNCVHLPAGLGRTSVNFEIGIHACGTAGNTENGLYGYGAESGSGTYFENIIVVQYDPQVQEVWDQARKLRCTWHDLYEKSVTFRPFPVDMLDVVRADFAGDNVGCWMQIQVGKGPWASEVSGLVKIGQTMTMVLAIKDDEAKFDMLVRNCMAHDGKRAPIQLVDQRGCITRPKLMSRFTKIKNFGASASVLSYAHFQAFKFPDSMEVHFQCTIQICRYHCPDQCSEGLDSGLGPGLLENSHPDVSYGLPPPLPLEAYLQAGAGRPRDERRRKSREVSLTTVGVNRIIRVVSTGDLTFAIDEKPEEDTVVVPVQAGSTLICMTTPKFAFTLIILLAIMLFSCILSAYLWIRLRPTTKKKCIVAYVTKKPKTCFYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H655</accession>
    <name>A0A8J2H655_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ER-bound oxygenase mpaB/mpaB'/Rubber oxygenase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS2556</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001117">
        <property type="protein sequence ID" value="CAG5077778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H655"/>
    <dbReference type="OrthoDB" id="6361347at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37159">
        <property type="entry name" value="GH11867P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37159:SF1">
        <property type="entry name" value="GH11867P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="132"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5077778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="511" mass="59192" checksum="DBB519A12A79ED35" modified="2022-05-25" version="1">MKHPECNDRELLADTKQFNDLSNETETTQLSGDKISGKNYINSDEQDRVIREFFKQLNVNLPADWEEIRDEERRKLICKWTSEGFPNIPKSLLKITTGWMVHGDCGRPADQVPDWLDREKFRRGQKFARDNMFGIYFSQLLTLFGLFSFEDGLKPMIVTGKSSEPYTAFKRYLSTGARVRNWFTSDPWTKGTSAYNDIQTVRRMHTIVRNKLSSISNEEIDKAGKIESPWSPTRNILLQDFRAECPVAKSGQCPFAAGTVRAVRPKGLHQGEMAVTQGGFVCLAVVYPEAFGLHGATDQDLDDFCHVWRGIGYLLGIEDEFNYCGGTLEEIKQLSADYLNQWVKPNLRDITPEWEHMMRCITVGMQYYFPGSSYEVSLLYLTELLNLDMPLLRSSLSYRDRFKFNITKFTMYYATRSPRVKEFLNSRLNKSIDRALKFTEEKHSELRKKSSKTLSVIQKNNNNNNINNINNKKDEKYLDVSIFSQYKIIGLVMLCVQCLIMWKVKFLSEIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H6H9</accession>
    <name>A0A8J2H6H9_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mediator of RNA polymerase II transcription subunit 22</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Mediator complex subunit 22</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HICCMSTLAB_LOCUS2815</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Mediator complex subunit 22 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001117">
        <property type="protein sequence ID" value="CAG5078697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H6H9"/>
    <dbReference type="OrthoDB" id="203279at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009332">
        <property type="entry name" value="Med22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12434">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12434:SF6">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06179">
        <property type="entry name" value="Med22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAG5078697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="141" mass="16238" checksum="4E842FD04440D624" modified="2022-05-25" version="1">MSNVRNLPQSKEALLKSYTIRLKDDVKSMLENFEGILKLAKGDTEAQQLTRMTQCEQDTYEMHVRAANIVRAGESLMKLVSDIKQYLILNDFPSVNEAIATNSKLFRQKQAECDQKLASLRDDMAADLYDLEEEYYTSIYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H6V7</accession>
    <name>A0A8J2H6V7_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS2951</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001117">
        <property type="protein sequence ID" value="CAG5079195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H6V7"/>
    <dbReference type="OrthoDB" id="7679028at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035320357" evidence="2">
        <location>
            <begin position="21"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="307"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="355"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="544"/>
            <end position="567"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5079195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="611" mass="71039" checksum="7393DC6CE0ADCCAB" modified="2022-05-25" version="1">MWVMRATLYCSLLFICNVSCNDIKIIKQTGISSHLHRDAKELVEMCFESNSNPVFISADLLSKDWDPGGNSWVVIDHKFQKQAMGFNSAYPTYVLSFESIGYLKVAINHFRKSTAWSIKSPFLIVERKSSCLSAGEKQDLLAVYYLCSHQDATIVFTLNPFATHPPAPWVFVLEFSDNRKKSTLYAMEYTKDSNICRKLTFDKTKKLNGHEEMKQKGSMTVYETLSLMEAKDNTWFFSSSAKITSFKNGYFRQLADKTIDALDKSFQLADTNFKYMDILTRYDVISYSILTKKSNYLTTISQVACNYQFLFLTIIMLMLIGMIIIINNKFDISSGILDVMSLTAGMGVITPLDRLSMRIIYIFGFLFVFTVMPEFQGQVSAILSEPLRRNVESLKDLHDNNYHVYFDAKLVRDIVKEKLWVTDEDMQYLHPSNYSELNKCAVEAEFNSTVACILFRSTQQWYASITTNLHVSRDVIFEKYFVNWVRKDWSLKDKLDRVSSWTTELGFHYGRLSQSFKYYTKKLRDIKRIEERASFEFIDFDTLILSYMIVLGLSIWGLVAFGLELLFHNYEKRRRQTLIRRRFRMELRSQLRNVSSIEQIIPSNPRTSFGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H6X6</accession>
    <name>A0A8J2H6X6_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Similar to Venom serine carboxypeptidase (Apis mellifera)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HICCMSTLAB_LOCUS2995</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001117">
        <property type="protein sequence ID" value="CAG5079371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H6X6"/>
    <dbReference type="OrthoDB" id="443318at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004185">
        <property type="term" value="F:serine-type carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001563">
        <property type="entry name" value="Peptidase_S10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802:SF472">
        <property type="entry name" value="SERINE CARBOXYPEPTIDASE CPVL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802">
        <property type="entry name" value="SERINE PROTEASE FAMILY S10 SERINE CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00450">
        <property type="entry name" value="Peptidase_S10"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAG5079371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="337" mass="38393" checksum="A392A0DC29CE4CBA" modified="2022-05-25" version="1">MSNTTRTSSSDPKNDPVVLWLQGGPGATSLWALVYQNGPFKIHNNKILSIRQYSYSSNHNLIYIDSPVGNPLFISGECYAGKYIPAFSYLIHQKNPTAKIKINLKGLIVGNGFVDPISQMHFGNHLHEIGLLDLNGKVRFNLYEEKIRSLIKSNQLTTALEVPNELLFNFPSVLSILTGFKSYLFNYLDNQNSDDWDALVDWIQRPDVRAAIHVSYDTPFKIINPIILKYLQHEFMKSEADKIAALLPEYRVIFYNGQLDMIIPYSSIETALLNLQWEGGDEFKKASRSVWWSGDELAGYVTKVWNLNFVLIRNAGHASGVYQPKWVLEMITQFTHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H7B1</accession>
    <name>A0A8J2H7B1_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Similar to TEAD1: Transcriptional enhancer factor TEF-1 (Homo sapiens)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HICCMSTLAB_LOCUS2948</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001117">
        <property type="protein sequence ID" value="CAG5079183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H7B1"/>
    <dbReference type="OrthoDB" id="10006572at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048568">
        <property type="term" value="P:embryonic organ development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035329">
        <property type="term" value="P:hippo signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.50.80:FF:000001">
        <property type="entry name" value="Transcriptional enhancer factor TEF-1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.50.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050937">
        <property type="entry name" value="TEC1_TEAD_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041086">
        <property type="entry name" value="YBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11834:SF0">
        <property type="entry name" value="PROTEIN SCALLOPED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11834">
        <property type="entry name" value="TRANSCRIPTIONAL ENHANCER FACTOR TEF RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17725">
        <property type="entry name" value="YBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="YAP binding" evidence="6">
        <location>
            <begin position="94"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF17725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAG5079183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="304" mass="34278" checksum="5636AA642726D752" modified="2022-05-25" version="1">MSSMSSAQIVSAGSIIHNKMPSALIGTLALHASTPSYPQPNFWQPGLQPGTSQDVKPFSQPAYTGKPATAVSSGDMVQAQPPPPWEGRSIATHKLRLVEFSAYMDQHRDQDIYHKHLFVHIGGSATYTDPLLEAVDVRQIYDKFPEKKGGLKELYDKGPQAAFFLVKFWADLNTNIQDEAGAFYGVTSQYESTENMTITCSTKVCSFGKQVVEKVETEYARFENGRFVYRISRSPMCEYMINFIHKLKHLPEKYMMNSVLENFTILQIVTNRDTQETLLCTAYVFEVSTSEHGAQHHIYKLVKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H7C0</accession>
    <name>A0A8J2H7C0_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to spopl: Speckle-type POZ protein-like (Xenopus laevis)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS3407</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5081903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H7C0"/>
    <dbReference type="OrthoDB" id="7555121at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24413">
        <property type="entry name" value="SPECKLE-TYPE POZ PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="207"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="587"/>
            <end position="609"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5081903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="609" mass="69189" checksum="F838DE9332CAD5D5" modified="2022-05-25" version="1">MPLQRNNQTIHKKVDTWVVNNVDKYNFIDDSKEDSLLVHEIHSGFDGKDKGIVKLIFCHNTQAFMRSCAFFEQVNEDDIKHHVVVTMYILTAENYYQPIGQQVYRTDTRMMKLRQYHTVLMNEEKVKAWPVEFTRAPLEQLHEKEVPFPIRKQPKIIINNTITLRIELLTYLDSEPMCPLNSLFGFTADVQQPEWILQLYENRNVSGDLTIKIQDNEFRAHKQVLDQRGFALNNATTEENNIFIFSDISPEIFGMLLEFVYTGAIKELDDFAEPLLEAADRFELKDLKSSCEKSLAENYVDYNNFADAYVLAKRCNAPELLSYAGSIEFVLSHGLDSERWSKNNPPTTEQLEKYLLPMNKIREAEGTCSALMRRAQFSDSLRRLANKFNVFSTNGTTPNPLKIPVIDMDHPCCRGCNAKIVGETVPCPQCSAKYHPNCALLTGTNSSGAFTRCCSRRRPASPLPSSIEALKESIIEELKNSLQDIIVTSVNTAIGPIIQSAMQQQISTLTRNLEDTFNKQLSSAFNEQVDAKLNEVHNSIAATASVLGQRGDEIETRLANLDQDTARIDNRCDNLKKDLKIAKLSPSISSRSDEPLLDEIEDGDKRKKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H810</accession>
    <name>A0A8J2H810_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Similar to TMEM183: Transmembrane protein 183 (Pongo abelii)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS3809</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5083336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H810"/>
    <dbReference type="OrthoDB" id="5955317at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031647">
        <property type="term" value="P:regulation of protein stability"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026509">
        <property type="entry name" value="TMEM183"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20988">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 183A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20988:SF2">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 183A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5083336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="312" mass="36712" checksum="097D02E130B228F6" modified="2022-05-25" version="1">MARSDKKHRNKARFIKKYDDFTVTGKTNGSECVNSSRIVDKLDKTHINNLSSSESGIDYPLDLWYLISEHIKPEDVGKFSVICKSSYYVTRTGKFWFHLYKRYYKPLPYLPERLRPECMVLLHGIRACVIRTLHFTYFSSLEKVNKNPYLEQKEPHSLVKRRCCLMWHKKGENHWFYYFKLKDISSNVNNTKNNCISNIINEEFHENNMLEEVAINPENNCRILRVTCLNYGMIPLVNSLILQSVKMDLSPGFKHHRLHLNFSSNYSSKVPTHVVILSGVVDCKVIDWWHPCYPHHDRVIDIPLPTVESWDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H816</accession>
    <name>A0A8J2H816_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Similar to GluRIA: Glutamate receptor 1 (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HICCMSTLAB_LOCUS3314</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5081544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H816"/>
    <dbReference type="OrthoDB" id="5984008at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001828">
        <property type="entry name" value="ANF_lig-bd_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01094">
        <property type="entry name" value="ANF_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="Periplasmic binding protein-like I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="91"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="Receptor ligand binding region" evidence="6">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAG5081544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="139" mass="16364" checksum="F081D8B3F232CEF5" modified="2022-05-25" version="1">MLGAVSPDSFDTLHSYSNTFQMPFVTPWFPEKVLTPSSGFLDFAISMRPDYHRAIIDTVRHYGWRKIIYLYDSHDGESQSSYAFLILQVTLYTYFFFFIVVFLSFGLLDTFLCLFLSTSTSYRSYFSIQNYEVNLFFML</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H8F4</accession>
    <name>A0A8J2H8F4_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Similar to Luciferin 4-monooxygenase (Photuris pensylvanica)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HICCMSTLAB_LOCUS4166</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5084655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H8F4"/>
    <dbReference type="OrthoDB" id="10253869at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016405">
        <property type="term" value="F:CoA-ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096:SF149">
        <property type="entry name" value="AMP-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="197"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="6">
        <location>
            <begin position="18"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAG5084655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="255" mass="28568" checksum="BFFBBF782AF86E15" modified="2022-05-25" version="1">MKKNQKSIGQIDSTIETQETFETMADKSVRCALWLQSQNIKEGDVIAICTHNHLNQIYPALAAMYIGAVMNPWWDHGLTPVIAKHFINLTQPKILFVNEECFNITRDVAREIKADLKIVVFGKAEGAESFDTIIAKQKPAEVQKFRCAKLSSVNHPALILYTSGTTGLPKGALHSHKSLFGNIQSVQDIINRDCVTAMWYSTLCWVTGILCSFSSISLGMLRIIPGPFVEEEACKIIEKYKSVQFSIKIRTAIYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H944</accession>
    <name>A0A8J2H944_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Similar to Gyc76C: Receptor-type guanylate cyclase Gyc76C (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HICCMSTLAB_LOCUS4695</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5088052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H944"/>
    <dbReference type="OrthoDB" id="5984008at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001828">
        <property type="entry name" value="ANF_lig-bd_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01094">
        <property type="entry name" value="ANF_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="Periplasmic binding protein-like I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Receptor ligand binding region" evidence="5">
        <location>
            <begin position="29"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAG5088052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="101" mass="11487" checksum="BA4162700E690D1D" modified="2022-05-25" version="1">MHEPDVTGEPKGKYTRHLCRHHFKLYPCYINNDPNLLPNVKLVMRWNDTKGETVEATKAMIDMICEGVAAFFGPEGNCYVEAIGVKKGLYRLKAEGELFKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H979</accession>
    <name>A0A8J2H979_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to slc16a12b: Monocarboxylate transporter 12-B (Danio rerio)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS3857</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5083499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H979"/>
    <dbReference type="OrthoDB" id="6509908at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008028">
        <property type="term" value="F:monocarboxylic acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF238">
        <property type="entry name" value="SD10469P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="60"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="94"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="121"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="155"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="187"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="451"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="516"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="344"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5083499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="553" mass="59894" checksum="CB52158B8EFA80FF" modified="2022-05-25" version="1">MAPSSTTESKSDCCESTKHPPENNLKNGNGKVNEEIQLDDCNDSDSEVEVDMVVPPDGGWGWVIVAASFMCNVIVDGIIFSFGPFVSALANRYGFRLVAISGSVISCLAFVLSYFSTSIEFLYFSYGLIGGIGAGLIYVPAVITAGFYFERWRALATGIAVCGSGIGAFVLAPVSQLLVKKFNWRQALLIQSGMLLTCTICGAMFRPLKPTRIKVKKSEVAQEAIEEVKSPLVNGKSASTHSLRGSQYLSVGWIFGTNNNAEYPTAAQVIASNPNIVKSIHSAHNILGLNGDLQLSSSEKRLSVPLYSDLDVKSSEAKEEENNLLDGSDLEKLNGGLSTTLQVRRHTISGRRDHGSQLSLKKAGSKRHQPTSKDPQRPFYRDDIFYGGSLARLPHYKSQLSSVGYHMSVTRLPTTTDVEEEKSGRCYLYPEGVSRILVTMLDIQLLKSPSFFILAISGGLTMMGFFAPFTYLPDRGMSYGFDNETATFLVSTIGITNTVGRILCGTSTSLPGVDALVVNNVLISISGIITIISALSYSKAYQFFYAAVYGSSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H9J6</accession>
    <name>A0A8J2H9J6_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Similar to Trpgamma: Transient receptor potential-gamma protein (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HICCMSTLAB_LOCUS4651</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5087933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H9J6"/>
    <dbReference type="OrthoDB" id="2373987at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034703">
        <property type="term" value="C:cation channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070679">
        <property type="term" value="F:inositol 1,4,5 trisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015279">
        <property type="term" value="F:store-operated calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051480">
        <property type="term" value="P:regulation of cytosolic calcium ion concentration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013555">
        <property type="entry name" value="TRP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002153">
        <property type="entry name" value="TRPC_channel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10117">
        <property type="entry name" value="TRANSIENT RECEPTOR POTENTIAL CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10117:SF54">
        <property type="entry name" value="TRANSIENT RECEPTOR POTENTIAL-GAMMA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08344">
        <property type="entry name" value="TRP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01420">
        <property type="entry name" value="TRP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-0407">Ion channel</keyword>
    <keyword evidence="3" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="ANK" evidence="5">
        <location>
            <begin position="56"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="Transient receptor ion channel" evidence="6">
        <location>
            <begin position="91"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAG5087933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="205" mass="23633" checksum="DA9726878022AC3D" modified="2022-05-25" version="1">MLELLLSVPNVDCSDTALHAIRDDQQQMAVMILNKMEEQRPHSEFAGAVDSSEFLDETTPMDVAAAYGHFDMIKLLADRGHSIKKPHPPDCYCREICKRERENEDPLTLDKKRLARYQAFSNPAHICHISSDPILIAFQLSSELGRAAVVQREWHKFYKQLSQSTKTIFFELAQAPKVLFLHGVPRLHYIPNFPREFPFSKLLIW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H9N7</accession>
    <name>A0A8J2H9N7_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="20">Similar to SPG7: Paraplegin (Homo sapiens)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">HICCMSTLAB_LOCUS4163</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">In the C-terminal section; belongs to the peptidase M41 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">In the N-terminal section; belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5084643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H9N7"/>
    <dbReference type="OrthoDB" id="1413014at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005745">
        <property type="term" value="C:m-AAA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034982">
        <property type="term" value="P:mitochondrial protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19501">
        <property type="entry name" value="RecA-like_FtsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.760:FF:000003">
        <property type="entry name" value="AFG3-like AAA ATPase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000277">
        <property type="entry name" value="ATP-dependent zinc metalloprotease FtsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000033">
        <property type="entry name" value="paraplegin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1690.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.760">
        <property type="entry name" value="Peptidase M41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01458">
        <property type="entry name" value="FtsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050928">
        <property type="entry name" value="ATP-dep_Zn_Metalloprotease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005936">
        <property type="entry name" value="FtsH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000642">
        <property type="entry name" value="Peptidase_M41"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037219">
        <property type="entry name" value="Peptidase_M41-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01241">
        <property type="entry name" value="FtsH_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43655">
        <property type="entry name" value="ATP-DEPENDENT PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43655:SF8">
        <property type="entry name" value="PARAPLEGIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01434">
        <property type="entry name" value="Peptidase_M41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140990">
        <property type="entry name" value="FtsH protease domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="16 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="7 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14 18" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="11" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="124"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="19">
        <location>
            <begin position="330"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="94"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="94"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="CAG5084643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="781" mass="87087" checksum="B754940A84437014" modified="2022-05-25" version="1">MQNIAKSTHRHLFLPKYFISSVVNLKPKEKKYFNRKFIKFWKESARNIFSSFPHNNFNTFSTECRSLGFYILSQNQFYQKFTINKLLKKQFGTSSVSHNKPSSSNGSQNSSDNKPPNQGDEKVAFIKLFLISCFVYGIFIYPMQRMAYKVEESPFVSWNEFVHKMLAKGEVQELIIKPDIDWVTIVLHDGAVINGKRSILRTYQMIVADATQLEEKLREAEKALGIPPGQGVPIVYQRVNENTSFLIALAVTIGILIAVSRSVNKSGLVRRDMFGGITRAKFTLVDPLTGGGKGVRFVDVAGLKEAKIEVMEFVDYLKRPEHYKALGAKVPKGALLLGPPGCGKTMLAKAVATEANVPFLSMNGSEFIEMIGGLGAARVRDLFAEARKRSPSILYIDEIDAIGKKRSGGSGMNQSTGESEQTLNQLLVEMDGMATKEGIIVLASTNRAEVLDKALLRPGRFDRHILIDLPTLPERKEIFDRYLSSIVLDKKPEVYSPRLAQLTPGFSGADIANVCNEAALHAARFKKKAIDASDISYAIDRVICGPEKKNHGVSPAEREIVAYHEAGHALVAWLLESTDALLKVTIKPTTRGVLGFAQYTPTERRNYSKEQLYEMMCVALGGRAAENVVFNRITTGAQNDLQKVTKIAYTQVRQLGMSDKVGLVSYSEEETGTNTKKPYSKKLANLMDMEARQLVAKSYKDTEKLLKNNMDKLEKISQMLLKQETLTYEEVEGLIGPPPFGKKKKVDCIELDESTSTTIENSPETQSTSQVSKCDKIIYNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2025-06-18" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HAA6</accession>
    <name>A0A8J2HAA6_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein RIC1 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HICCMSTLAB_LOCUS4984</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5088790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="67540at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034066">
        <property type="term" value="C:Ric1-Rgp1 guanyl-nucleotide exchange factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040096">
        <property type="entry name" value="Ric1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009771">
        <property type="entry name" value="RIC1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22746:SF10">
        <property type="entry name" value="GUANINE NUCLEOTIDE EXCHANGE FACTOR SUBUNIT RIC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22746">
        <property type="entry name" value="RAB6A-GEF COMPLEX PARTNER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25440">
        <property type="entry name" value="Beta-prop_RIC1_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07064">
        <property type="entry name" value="RIC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69322">
        <property type="entry name" value="Tricorn protease domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RIC1 C-terminal alpha solenoid region" evidence="5">
        <location>
            <begin position="782"/>
            <end position="936"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="935"/>
            <end position="962"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="986"/>
            <end position="1034"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1118"/>
            <end position="1176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1022"/>
            <end position="1034"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1123"/>
            <end position="1137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1138"/>
            <end position="1166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00029879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAG5088790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="1401" mass="156776" checksum="9110241781EC4D13" modified="2022-05-25" version="1">MFFPIGWPRVLNPSELNQINAIVCNRDKILFAILTRDTLAIWYCKPCVPIVFHRRTKDSIEKYGENLLVQWKPDSSMLTVATTESYLLFYRLSDSGGDNHGLYEQKDSPVSSLRRDSAELFIKEVIPSLVLTFVIPVWIDGGISSLVCIRDELMVATKTSIIIRQRWEGSVNRDYSLDLKRVPFSVDQQISTVAVPITDNNIYVTDIEYSPLVGGFAIVLSNGKAAFLTAQSLKFDPNQVQGIYAKDLDDATCAAVNHKYRLIAFGRKNSQGVVYYVDETTGGLEVSHTLSLSSKDYPGRPGNVKCLRWTPDSCAIALAWDTGGLAIWSTFGALLLCTLKWDYGLHVDLTRDNPLRVHTMEWSAEGYQLWMLRESPNNTINQENNEDVVNQECSLIQLDFVKSPLTGHHGHLYLQGEDRLYLNLGGVVTDTPNFHLGNDIVNDSTCQTLAGSKQWLVVPIPSVYSGSNWPIRYTAIDNEGQNIAVAGRTGLAHYSLSSRKWKLFGNENQERDFIVTGGLLWHRGFMIASSYSIVEDKDEIRIYPRDTRLDNNYVKSVRMPSQVLLVNTMKERLVIFCANAQVSIFDMTLEGIEGTGSIELTRTQIVDISGLCVHPACVVSVTLTTIRAETAGTHPHPESLLLNVSGKLLMVQREHCTDNTEVLFTCGAPNVLASCVENVWVPWRSRRDKPHLTEALWLFCGAHGMRVWLPLFPRNHQDNAHTFMSKRIMLPFQLKIYPLAILFEDAIILGAENDTVLYTSDSNSPFSLPFSLLELTSQVYLHQILRQLIHRNLGYHAWEIARSCVALPYFSHSLELLLHEVLEEEATSKEPLPDAQLPSVVEFIREFPGVWARAVVQCARKTEIALWPYLFSIAGSPKKLLQDCLQRQQLDTAAKPSSVSRQHATLLLDAALEQGRWELSRDLVRFLRAIDPNDVESPRNSWGGSGKLSGPPPTPSVSPHEEDLSLVLGTMQVSRSRSYSTTITPKVQFDSNKDPPSSMLEKTRNAVMRRKKSVPSFKPEKNNNNINNNNSNNNQETAEEFFIDVILQRHARRLLSARRLADLGHFAARLDFYLVSWLARERERAAKIDDFIIALKAAHEDFSFPYPTLSLTNLEKLRRPSHAMSTRSRSVEYSENETQTTTTFTNNINNNNNNNNNNNNNNNNNNGDLPADSGYTSLSSTRPGGIYGLVSPVASLETQFPIVETKLTPRIHQDAGSVLSDTSTIWRDDVESVVGTCWVSSDAIEPVDNNLSSICGPTSRAQVQVRYLLQLFLEAGCIGWAAVLSTMLRDASAMARTIRAAHAPMQTLEHSSVSQASLTVASTVTAATPNTTKEEIKIDELFPGTGIGKEAIHNGSNEKYDDSQQQSNCVISRFRGGVFCTMDSNCSTNTRCIKRRMSLRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HAU1</accession>
    <name>A0A8J2HAU1_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Large ribosomal subunit protein mL50</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">39S ribosomal protein L50, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HICCMSTLAB_LOCUS5377</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrion-specific ribosomal protein mL50 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5089791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HAU1"/>
    <dbReference type="OrthoDB" id="9939609at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018305">
        <property type="entry name" value="Ribosomal_m50"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31542">
        <property type="entry name" value="39A RIBOSOMAL PROTEIN L50, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31542:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG5089791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="251" mass="28228" checksum="8ECE38598207C03F" modified="2022-05-25" version="1">MAALIRHGSLISPHSAKNSLLSLIKAPVRHDVVRCKANRAKQKQKQSTIKGKWEWSEKSLSTRGASIIGFTGVYFQICRTDVLTCSNSDCENLGHFEVPPPPNSSPFLRPLKPYEPPADASEKLDKICKAEGLSENDSTEIKDLNLRFKLFSACANEFKCHIPNSVMFTIRTIGDLRNFYHTPINTTLPLEATKDLELPPNLHIQYEYNRFNPETDTKFGGKTAFPKSSTLVTGLKYKKKYPSLILDSPWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HB73</accession>
    <name>A0A8J2HB73_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Peptide deformylase</fullName>
            <ecNumber evidence="7">3.5.1.88</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HICCMSTLAB_LOCUS4949</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="5 7">Removes the formyl group from the N-terminal Met of newly synthesized proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>N-terminal N-formyl-L-methionyl-[peptide] + H2O = N-terminal L-methionyl-[peptide] + formate</text>
            <dbReference type="Rhea" id="RHEA:24420"/>
            <dbReference type="Rhea" id="RHEA-COMP:10639"/>
            <dbReference type="Rhea" id="RHEA-COMP:10640"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:49298"/>
            <dbReference type="ChEBI" id="CHEBI:64731"/>
            <dbReference type="EC" id="3.5.1.88"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the polypeptide deformylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.88" evidence="7"/>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5088706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HB73"/>
    <dbReference type="OrthoDB" id="276063at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042586">
        <property type="term" value="F:peptide deformylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00487">
        <property type="entry name" value="Pep_deformylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.45.10:FF:000003">
        <property type="entry name" value="Peptide deformylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.45.10">
        <property type="entry name" value="Peptide deformylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00163">
        <property type="entry name" value="Pep_deformylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023635">
        <property type="entry name" value="Peptide_deformylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036821">
        <property type="entry name" value="Peptide_deformylase_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001159">
        <property type="entry name" value="PRK00150.1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10458">
        <property type="entry name" value="PEPTIDE DEFORMYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10458:SF2">
        <property type="entry name" value="PEPTIDE DEFORMYLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01327">
        <property type="entry name" value="Pep_deformylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01576">
        <property type="entry name" value="PDEFORMYLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56420">
        <property type="entry name" value="Peptide deformylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00037114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG5088706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="250" mass="28519" checksum="6A1F58C0736FBC82" modified="2022-05-25" version="1">MIKLLSNSVVIIKNFHNKAFVRQMSKFSGFEEKVYQYLQPIDLAKPPYSHACQIGDPVLRLQAKPVELEIIKTAEFKKFVEHLIKVMRTYDAFGMAAPQIGVSSQVFVIETTKKQYDEMMMSKSAGQPIEEIPLKIFINPQIKITDFKVTNYPECCASVCGMMANVPRSKGVQINALDIDGEPFTWDAVGWPAKVAQHEFDHLQGKLYTDTMDRKTLSCMVWQTVNRRGGKISIDYIPIARSKLRKLFFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HB97</accession>
    <name>A0A8J2HB97_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similar to pol: Retrovirus-related Pol polyprotein from type-2 retrotransposable element R2DM (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS5726</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5090720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HB97"/>
    <dbReference type="OrthoDB" id="7696066at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071897">
        <property type="term" value="P:DNA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47027">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47027:SF30">
        <property type="entry name" value="THAP-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5090720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="187" mass="21391" checksum="3323B939A2475ABC" modified="2022-05-25" version="1">MDHLNHRGIALVEDNKIVPEAQSGFRPNRGCLDNLFVLTTVLNCRLRQKKSCVISLRAFDSVNHKLLWQKLFEVGRSTKIVRLLRNIYNSATLKLRINRLLSKDFKINEGVLQEELLSPLLFIIFIADLEPFMRNNECEGVNIDGYTDVLLLLYADDLVIMASSEADLQKKTNSSRYIVHGTICKLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HBJ4</accession>
    <name>A0A8J2HBJ4_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Similar to Gtf3c5: General transcription factor 3C polypeptide 5 (Mus musculus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HICCMSTLAB_LOCUS6351</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5092749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HBJ4"/>
    <dbReference type="OrthoDB" id="5598268at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000127">
        <property type="term" value="C:transcription factor TFIIIC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001002">
        <property type="term" value="F:RNA polymerase III type 1 promoter sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001003">
        <property type="term" value="F:RNA polymerase III type 2 promoter sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006384">
        <property type="term" value="P:transcription initiation at RNA polymerase III promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.160">
        <property type="entry name" value="TFIIIC, subcomplex tauA, subunit Sfc1, barrel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019136">
        <property type="entry name" value="TF_IIIC_su-5_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040454">
        <property type="entry name" value="TF_IIIC_Tfc1/Sfc1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041499">
        <property type="entry name" value="Tfc1/Sfc1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042536">
        <property type="entry name" value="TFIIIC_tauA_Sfc1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13230:SF5">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR 3C POLYPEPTIDE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13230">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIIC, POLYPEPTIDE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09734">
        <property type="entry name" value="Tau95"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17682">
        <property type="entry name" value="Tau95_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="Transcription factor IIIC subunit Tfc1/Sfc1 triple barrel" evidence="7">
        <location>
            <begin position="54"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="domain" description="Transcription factor IIIC subunit 5 HTH" evidence="6">
        <location>
            <begin position="288"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="178"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF09734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF17682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG5092749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="585" mass="67296" checksum="051C90E782152374" modified="2022-05-25" version="1">MLIKKEPVASSYNQFFFSDDSNDEESNVNVKEEEEEEEIGPILPGGHRLDKKFYCIKYPGKVINPEKAIENLGGLGSISTTINTPNRRLELKLRKSDIYCKPACGDRHEVSGFLLRIRVKKSRVKKATELAKQKEVENYRNLTPAMPRDLSKQNPIENFDREEIKRLSKELRNCEIDAQQNRSKTAGGNEKNESLIDELSGDSSKNIPLKFSCNKIEDLANETDYKLPKLKILGRVVMEFKFTSLIDFQYTPVTQSVTDPKKRECIYDSICPKGILTPEWLAKKVPYFLPPAVFSRMDTIQQYNLKLDVKETESENVIGKNRKSRAGLTYNVPFTTEIIPSVPKPGIDKSMAAKLLTNEDLQVMVKLFEKRPIWSRTALLVKTKYHKDQIRVLLPSVAYYFTTGPWRLMWVRLGYDPRKDPAARIYQILDYRCKAMHGLEKYVKGKRSYTNSLIPYKSASAAKASKASASASLSEIKRRTKTNLYDENDYIYRRGNIPSSRQTLYQFCDVLTDEIQEMFAKLPDPMPGVKCDEKRGWLPPGFSEHCREIINKQVLVMLRKKMNIPINSTCSHYTTVEIYGLRIRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HBW3</accession>
    <name>A0A8J2HBW3_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Probable ATP-dependent RNA helicase DDX52</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">HICCMSTLAB_LOCUS4469</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the DEAD box helicase family. DDX52/ROK1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5087273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HBW3"/>
    <dbReference type="OrthoDB" id="360161at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd17957">
        <property type="entry name" value="DEADc_DDX52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000759">
        <property type="entry name" value="probable ATP-dependent RNA helicase DDX52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044764">
        <property type="entry name" value="DDX52/Rok1_DEADc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050079">
        <property type="entry name" value="DEAD_box_RNA_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE RHLE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959:SF15">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 13 18" id="KW-0347">Helicase</keyword>
    <keyword evidence="4 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="17">
        <location>
            <begin position="132"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="15">
        <location>
            <begin position="163"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="16">
        <location>
            <begin position="352"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="39"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="520"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="12">
        <location>
            <begin position="132"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="520"/>
            <end position="533"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="CAG5087273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="559" mass="63580" checksum="123889ECC2F42329" modified="2022-05-25" version="1">MDAFDLFKKLSSGTKFDKRRFRTDIEKFKISKSKNEEITIKTEPVDPVPSSKRKRDQVSNDEQISEGSSLVLLNGISLPADGVKVKKNKKIKISDEEKKIMLEQEKINRLRNEHRISVIGKNVPKPIKSFEDLKTFYNVPEDLVKNLAECNYSTPTPIQMQAIPIMLEKRPLLACAPTGSGKTAAFLLPMINHLKGPEKRGFRAIILNPTRELAKQTYRECVRLSEGRGFRIHIISKVDQALEKYGPKSSQKFDILITTPKRLLCLLNHEPPAVSLQNVEWLVIDEADKLFEAGPRSFRSQLKQISTACTSENLRIAMFSATNTFIVNKWCKRHLKGLVRVTIGLKNAATELVDQELLFVGSERGKLLAFRDIISKGMAPPVLLFVQSKQRAKQLFDELIYDGINVDLIHADRTQIQRDNVVRCFREGKIWVLICTELMSRGIDFKGVNLVINYDFPPSAISYVHRIGRTGRAGHKGKAITFFTEDDTTNLRSIAVVMRASGCDVPDYMLRMKKYDKRERKKLEKVAPKRDSIASKPRKLKIKKKVGESTQKSPESKKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HC03</accession>
    <name>A0A8J2HC03_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS6889</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5093513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HC03"/>
    <dbReference type="OrthoDB" id="7694521at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5093513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="145" mass="15253" checksum="8F26C215CE3B3C80" modified="2022-05-25" version="1" fragment="single">VVFLALVAYASAGSGLVAPYGYGHGYSYHNYPSVYHAPTVSYSPSVYHTPLATSYANTHKIAYSAPVVTKVLAAPTVTKIHYATPVAAYVAPHYSGLSYGHGYGSYGLGHGYGSGYGYGNYGHGYGLGHGYGVGHGYGYGHGYWH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HC79</accession>
    <name>A0A8J2HC79_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Kinase</fullName>
            <ecNumber evidence="4">2.7.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HICCMSTLAB_LOCUS4724</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the inositol phosphokinase (IPK) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.-.-" evidence="4"/>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5088133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HC79"/>
    <dbReference type="OrthoDB" id="338650at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000828">
        <property type="term" value="F:inositol hexakisphosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032958">
        <property type="term" value="P:inositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.160">
        <property type="entry name" value="Inositol polyphosphate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005522">
        <property type="entry name" value="IPK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038286">
        <property type="entry name" value="IPK_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12400">
        <property type="entry name" value="INOSITOL POLYPHOSPHATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12400:SF26">
        <property type="entry name" value="KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03770">
        <property type="entry name" value="IPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56104">
        <property type="entry name" value="SAICAR synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="31"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAG5088133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="318" mass="36722" checksum="9BC7ECB1F4FF4879" modified="2022-05-25" version="1">MSSGVMSRMETFTPRLCLKAVDQYETILQSRLSKSTKSPRNQQRVKNESSNTSIGRSYSVFRQWKKNDRDSKCNMDVSYIDDTKTNSLSSSLPNYYREVEYKGDTFIELQDLLFGFTDPSVIDIKLGTRTFLESEVSNNVARTDLYKKMISVDPNAPTNFEHENQAVTKLRYMQFREQQSSTCSHGFRIEAMKLPGAPPITNLKKIKEHVAVVETLKLFLGRYSITYEKLLEQLKDMRSRIEASSYFKTHEVIGSSIFIIYDEKKIGVWLIDFAKTYKVPDGKELSHRKPWKEGNHEEGFLLGIDNLISTIEEIKITL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HCV5</accession>
    <name>A0A8J2HCV5_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SWIM-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HICCMSTLAB_LOCUS5706</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5090645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HCV5"/>
    <dbReference type="OrthoDB" id="123417at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049218">
        <property type="entry name" value="DUF5575_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052579">
        <property type="entry name" value="Zinc_finger_SWIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007527">
        <property type="entry name" value="Znf_SWIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048324">
        <property type="entry name" value="ZSWIM1-3_RNaseH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31569">
        <property type="entry name" value="SWIM-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31569:SF4">
        <property type="entry name" value="SWIM-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20784">
        <property type="entry name" value="DUF5575_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21056">
        <property type="entry name" value="ZSWIM1-3_RNaseH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50966">
        <property type="entry name" value="ZF_SWIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SWIM-type" evidence="3">
        <location>
            <begin position="509"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="631"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="631"/>
            <end position="640"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG5090645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="726" mass="84682" checksum="86F7A41C883AC9C0" modified="2022-05-25" version="1">MLSEAAFRYLLANYKCKALQISPITLVTSVLDKILYPVVISFLNNNQQHCYEKIVHRKKNKFESREKFLNQICNKKLSNQKISYHLSIKKEHALIQTTRIEDYFLVAYFVTKTALHIIGWRRDESRKHPSYTLWLRQLYMSIIIFDIAGKIDHKYHDGSEVMSDLYPENRRLDPDYAERILDMMDVKANKKFLQAKIKSDTEKTVFIKDLHNLSKKRKKVTQENCLTMAADYLKDKGATVHILKKNLEFMGLSFYTPDMIKAMAAYPEIIFMDGTYKLIDTDLTVMIIIGMDSDEKSRIISVGLLVNEQYETVKWYLSTFIEENQQVIQKVNCVMTDKDSVERKVIAELLPHVKNYLCLFHTLQTFNREITCSKRNITGAEKEIAIRYVQQLAYSNSETQYNEIYNEFKNKVPKSVVDYFNTNWHNIRDQWTCYSMIEDTINNTTNNRLESLNGKGSKETDTNKTMFNNFFKCSTDEDLDEYMRDYRNYLTEAGFKHLRQEIGGSPQVNLVNIDLENKESYIHSKAEIIMITVNTCQCKFHRSLKLPCKHILALREKCNLSLFSESLCNDRWTKTYYKQKMLPTNQTSDICDCNDKRTKITNIENTAASNQKHTENQNNLRELDEIKIPKKTKGRGRAKGKSTSVIGLPKQSTAKDNSKNVYKIASSKPTIISNELFTSNLKIKQNQLNNDSPSTLNNEIDNIQENILHEVGLKEWIKQFLDDTKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HDT5</accession>
    <name>A0A8J2HDT5_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">FGGY carbohydrate kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HICCMSTLAB_LOCUS5514</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FGGY kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5090169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HDT5"/>
    <dbReference type="OrthoDB" id="203824at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019150">
        <property type="term" value="F:D-ribulokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019321">
        <property type="term" value="P:pentose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000101">
        <property type="entry name" value="FGGY carbohydrate kinase domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018484">
        <property type="entry name" value="FGGY_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006003">
        <property type="entry name" value="FGGY_RbtK-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01315">
        <property type="entry name" value="5C_CHO_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43435:SF4">
        <property type="entry name" value="FGGY CARBOHYDRATE KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43435">
        <property type="entry name" value="RIBULOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00370">
        <property type="entry name" value="FGGY_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carbohydrate kinase FGGY N-terminal" evidence="5">
        <location>
            <begin position="3"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00074355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAG5090169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="320" mass="34642" checksum="3CEAC3C7379D2A2A" modified="2022-05-25" version="1">MEYYVGVDVGTGSARAALYDSDGKLIKLSTYHIETFNSIPDFYEQSSEDIWQAVKRVVKTVVHDTPKNLIKGIGFAATCSLVLCDENGQPVTASSTGDDNRNVILWLDHRAEAEANFINMMGHDMLKYVGGKVSLEMEIPKIMWVKKNLPKSWNRAKLIFDLPDFLTWKATGCETRSLCSLVCKWNYQANPEGENGWCEDFLNKLGLASLKDDNWKRIGRKAQAPGEPVGKGLSSIAASELGLNEGTPVGTSIIDAHAGGLGMIGCSAPGVSESFTSRLGLICGTSTCHMAVSEKAIFVGGVWGPYYSAMACSTISFGSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HEM1</accession>
    <name>A0A8J2HEM1_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS6595</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5093119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HEM1"/>
    <dbReference type="OrthoDB" id="10375864at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="162"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="181"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5093119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="276" mass="31675" checksum="B481E24FB9B342DE" modified="2022-05-25" version="1">MASFCLITNTNRSKYYIVPTTSVYQLDEKDELQPVKPSQYQDGSVCYVRDNHLKLGNATFTIVDTDDDYNAIIKRNPVDTRIITSKLPEYSPRLISDQSLKKTSKKKKGTLATSRDNNVQDSGDYYRIRLAEPAQKELPELSDNNVDDEDDGANKENDKSPPLNQTPSLNETRSPDETDLLNETSPMNQIRKSLQTPRPRKKFGMRRPYNATVRQLNTISKNLVKIRKAQRNIKNKNGNLQQPQQQQTSKIPNFIETITVENDVENSAYIYNDERK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HEN1</accession>
    <name>A0A8J2HEN1_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NADH:ubiquinone oxidoreductase intermediate-associated protein 30 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HICCMSTLAB_LOCUS8554</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CIA30 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5097125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HEN1"/>
    <dbReference type="OrthoDB" id="426386at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010257">
        <property type="term" value="P:NADH dehydrogenase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013857">
        <property type="entry name" value="NADH-UbQ_OxRdtase-assoc_prot30"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039131">
        <property type="entry name" value="NDUFAF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13194">
        <property type="entry name" value="COMPLEX I INTERMEDIATE-ASSOCIATED PROTEIN 30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13194:SF19">
        <property type="entry name" value="NAD(P)-BINDING ROSSMANN-FOLD SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08547">
        <property type="entry name" value="CIA30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035314526" description="NADH:ubiquinone oxidoreductase intermediate-associated protein 30 domain-containing protein" evidence="2">
        <location>
            <begin position="20"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="NADH:ubiquinone oxidoreductase intermediate-associated protein 30" evidence="3">
        <location>
            <begin position="28"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG5097125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="176" mass="19477" checksum="B3D45CA347F69A06" modified="2022-05-25" version="1">MKLSHMIASIMMGVTWTQAVKGNRYSLFDFTTASNVDNWSEISDTVRTPGMSKAVLTLQKTQLFQRGIFFTLLNPQPNGAGFAGVRMPTTWDLSGYTSIEIKCRAQGNNEHYKFSTISLPLKNFKPYYRGQEVLNGTPLDTANITTFGLQVFGGVYSPFKQSGVSALEIETIVATI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HEU9</accession>
    <name>A0A8J2HEU9_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HICCMSTLAB_LOCUS8085</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Centromere</location>
            <location evidence="2">Kinetochore</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5096189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HEU9"/>
    <dbReference type="OrthoDB" id="18453at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000444">
        <property type="term" value="C:MIS12/MIND type complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007128">
        <property type="entry name" value="PMF1/Nnf1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03980">
        <property type="entry name" value="Nnf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="9" id="KW-0137">Centromere</keyword>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="5" id="KW-0498">Mitosis</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="123"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAG5096189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="196" mass="22250" checksum="3237D14BD07196A6" modified="2022-05-25" version="1">MDVLEETTDPKPVTHQSDNALVFRATITSIMKNICESVSEEEFSKCLTYLSSKPAIVGKLHKILMKDMYESMETELEEILSDLNLASGLGKLKELTAETTRRPDEIAWRPPGNVKEHLRTLDAMKIIAESKKLEEILSNLEAENTLLRERVKEKRSLAHKVEDRVTRAFKSGSLSLSHMEKTSESMQNYLKILGND</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HEY2</accession>
    <name>A0A8J2HEY2_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS8766</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5097565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HEY2"/>
    <dbReference type="OrthoDB" id="6077919at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="164"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="463"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="479"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="489"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="510"/>
            <end position="521"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5097565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="527" mass="57172" checksum="92028963267919D4" modified="2022-05-25" version="1">MDLTEAFPGGSDAADDLGKTDFFDFVVSPLSAAPSHCSGTIDDDTVNYLQHRQSRRMYLQDGRRDDDGREIHSTSTSFIKQETNNNTLTALPPVSTITGSLNHHVRNHCIQSSEIPMEADCDYWGTTDDVKDGQQTCNILLEDLNKYCWTTHANPQCRDDVNDTEGHHQNPHHRVSVGNDRHQNTDGAIYTLTVLNNETNSMDGLDCCKSPVASNNDSWTLRPNLDLDAILNLESSHPDADSVHDVQNSAEIARNNERYHIISTTPSSQYATDDSGFVERDNNNDWKLSDQNHLQEVSGDSAESLLRNALQGKLYSGPTQITLASSTKSTGIAVSLSTGSNVIKQEPQDESMHGCTEEDLLLSQLETTTYRPGDYEKLKSIANEVVENYCNLEPVCNVSGTTTLMYTLDPTSGSLGTITLPAELGQVGTVTVVTAAPQELTDQTAARSDDSGGQIQVVTVNNRPMISNSTTTTTTTAKPAKKYSRKNNRNAANANSAAAGANGSVDSGNQSAPGSLPSATVQRKERL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HF12</accession>
    <name>A0A8J2HF12_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Similar to Ift140: Intraflagellar transport protein 140 homolog (Mus musculus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HICCMSTLAB_LOCUS6755</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5093337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HF12"/>
    <dbReference type="OrthoDB" id="10258787at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005930">
        <property type="term" value="C:axoneme"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030991">
        <property type="term" value="C:intraciliary transport particle A"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035721">
        <property type="term" value="P:intraciliary retrograde transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.470">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056154">
        <property type="entry name" value="Beta-prop_IFT140_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056155">
        <property type="entry name" value="Beta-prop_IFT140_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056168">
        <property type="entry name" value="TPR_IF140/IFT172/WDR19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15722">
        <property type="entry name" value="IFT140/172-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15722:SF7">
        <property type="entry name" value="INTRAFLAGELLAR TRANSPORT PROTEIN 140 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23383">
        <property type="entry name" value="Beta-prop_IFT140_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23385">
        <property type="entry name" value="Beta-prop_IFT140_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24762">
        <property type="entry name" value="TPR_IF140-IFT172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0966">Cell projection</keyword>
    <keyword evidence="5" id="KW-0969">Cilium</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="2" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="IFT140 first beta-propeller" evidence="7">
        <location>
            <begin position="2"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="domain" description="IFT140 second beta-propeller" evidence="8">
        <location>
            <begin position="424"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="domain" description="IF140/IFT172/WDR19 TPR" evidence="9">
        <location>
            <begin position="769"/>
            <end position="939"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF23383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF23385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF24762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAG5093337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="939" mass="106834" checksum="1C9CC3D5034075B0" modified="2022-05-25" version="1">MALYFDNRIQNLVPSSINNYAIWHPNFPLLAIAGYSQNKGIYVTIYDDHGQLIHDLKSHEVSIFQISSISWHPKLKLLIIGKDNGSIQIWTEDFERNEFTEVGAPHRDSITLLEWSQNGGRLVSADAAGSIVGWRVDNKGQLLIIFHHELQKSFTHITFKPIVFTPKNLNNEKIIADDNRSLNLFNNWRPRTAVQIPQFQKDNYAFFIGSLDGFIYYIDTKGHCKQVLNTGGITLCGLLHHQSRDSIVVMTEGFNVSQFQIDSFTGELTEMIKVKLSGKSNDFKVKNTLCWIGNNTLAILTGELSLRCWNLQNGNTYVLSPTMLTSENVSNFQEVYISFTFCKINQTLAAGTNLGTIHFWKREFLTCNNEYGWPFTPKSCTVDGTVKQLTWGGAFLRYPVFAANCVANVFIFHEQPMCAAYNEDICVSQVSPTKLIIEKENESSSLITDIQVQMLAINKIYVAVSSGKQVVTYSIHKSEVLHTLIEQSFQCDVEKILIYESTLIILTASLIQLRTIKGNVVQNLPILPEEGEPITMELTGQYLTVASLNGILKIWDLSKRLAKLHTRTLAVYDVIKDFAEIIEAKCNSDCRCVSITVATSNLLPSSILYIWDIEGDQIFEFDYAKLSENHQNYSEVISKSQGRFVVTHCWDVIDPRVLVCQTQTIPTYNVQNFCNPKRMSNVFKNVVLVSMFITPEHGITIHDYRSLEEFYCRLIEVKSPYIIVFDSEKEGHGSKLTKLFMREFEELGFCDETIKKAIMDFSFHISMDNTDEAFKSIKTIKNEAVWRSLAKICVKTKQLNMAVLCLGHMKCVRGTKAFRQSIINSNLNLETRIANLAVELGLYADAERLFREAGRLDLLGNFLETCNRHSEAITLAVNENKISEKLSYYNYAKMLEQQGNVEEAIKMYTKVNSDKFEISKLLFNQPKELHSYLAASNDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HFH0</accession>
    <name>A0A8J2HFH0_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Similar to UTP4: U3 small nucleolar RNA-associated protein 4 homolog (Homo sapiens)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS8800</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5097633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HFH0"/>
    <dbReference type="OrthoDB" id="8883818at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034455">
        <property type="term" value="C:t-UTP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011044">
        <property type="entry name" value="Quino_amine_DH_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046351">
        <property type="entry name" value="UTP4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44163">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44163:SF1">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50969">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5097633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="692" mass="78227" checksum="FCDB1E68D86A6D66" modified="2022-05-25" version="1">MASYKIHNVRFYNLEPRSIVCMCYDNVNEKLAVARNDNTIELWNVSYAPFLESTIVDHLEESIESMIFINQNRLLSTGLRGFVTEYNLSTLSKKNELAVTGGAAWCLDINPSKTRVAVGTEDGYINIFTVLQDFLRYEGLLNKQKGRILCIKWDITGDKIFTGSSDTVRVWDAVSGHVIHKMTTARKEVKKETIVWCLGVTNDNQIVSGDSRGVLSIWDSVMGTLIESHNSHTADILALTITQDSKVIYCAGVDPVVRSFVKVVKPGRGAASWVKGIERRLHLHDVRALVEADNRLYSAGVDGYLAQSSYPPKMLAKYPPLLQPTCVTVCPKKRRVLLRYVDFLELWELGSAAEDSAVTPGMFHSLENEPRKLLELRTKKQETITSYAISRDSKLIVYSTETHMRIFKFKVNGDDAQLTKATADRMLKRVHRMLFSPDGKLFVANTNSSDGDESEEVGNRIHVYRKGDDSLMLVKSFCTAEQKLDNIGLMCFSPDSKYLVCSDRSGGIVVYVVAELGSMSPEWWSLPRYSCPPTAMAVQKSSSNLVVVYADQKIIEYNLPRRLFTEFSMNLQSKLPSNWLARYFPITNVTFDPNNESVIILNDDTTVYALHKNRDFQIVDKANKVMKLEEDNSRSSSGSSSQTQSVCQLIKKYKHLVHLEWFNNEEMVAVEVNPISLTEKLPPTLKQKFFIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HFK3</accession>
    <name>A0A8J2HFK3_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Similar to TMEM14B: Transmembrane protein 14B (Homo sapiens)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HICCMSTLAB_LOCUS9203</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5099725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HFK3"/>
    <dbReference type="OrthoDB" id="7692670at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1740">
        <property type="entry name" value="Transmembrane protein 14-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005349">
        <property type="entry name" value="TMEM14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044890">
        <property type="entry name" value="TMEM14_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03647">
        <property type="entry name" value="Tmemb_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="39"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAG5099725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="76" mass="8241" checksum="883F1F78623F595A" modified="2022-05-25" version="1">MSDFFPLFPIFSLNCSTFAFAAGIAGVGVYNYKKTNSKISLIAGLSYGSVLTCAWYSTVNHPFEIWGIMATTATVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HFL0</accession>
    <name>A0A8J2HFL0_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS6696</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5093255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HFL0"/>
    <dbReference type="OrthoDB" id="7697417at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46704:SF9">
        <property type="entry name" value="BHLH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46704">
        <property type="entry name" value="CXC DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5093255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="573" mass="67331" checksum="10D9E767B466896A" modified="2022-05-25" version="1">MKSTDDITKDLKKSTINKSTKNLEVMMQLMKQNTNPFAPELSEDHLYNISKGQSVNDEIYKFLSSVEIEGEKQKNFIAETRVTPDRFDKAITKNKIINFDYKNTQKVKINGKMKEVKMQRDVFGRLLYASLTNKIDIEKASSYSLAPIPFSLCHTNGTICKTFKSVVINELLEYQNEIVNPPEAHIHLVDGFHLLHTLKNLPSKYGKISMHTLKMLTYNRKEVHIIFDNYKKPSINDFGHDDLRGEEDTQYDVIRKDNNRPADFCKLLRSNNFKEKFVEFLIEDWTRDEFITLITGKTIKFNYDQCYSYEVSSENKIKRVIDYNLSCYHEEASTKIVYHICQLNTNYRVEIHCADSDIPIIMLENFKHLKDNIEIIINYSMRKKRPSSILMKNENFQEAFIKLLRIENSALTTSNEVQYFFLIREIIEEYVCRVYSLKTKNDINRGRYELFEKGYKSKNESEEILKRKIVGYDPSSLPPTKQELLQQIKRTVFICNVWCNAHMRYPMEKLPENFGWTIIDGKYEYYWFDGPQSPSFEELSSDMQVSNDKSGLVVLTISERRTGITYHATCRTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HG05</accession>
    <name>A0A8J2HG05_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS6708</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5093267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HG05"/>
    <dbReference type="OrthoDB" id="7700460at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2590">
        <property type="entry name" value="BEN domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040391">
        <property type="entry name" value="BEND5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14628">
        <property type="entry name" value="BEN DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14628:SF1">
        <property type="entry name" value="BEN DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="143"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="352"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="81"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="368"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="385"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5093267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="406" mass="45449" checksum="364446B4C39FAA0F" modified="2022-05-25" version="1">MKSLNARSRFIETLRGDLPLRRILLRTKIEVKKVLKNSTLGEKFKKQLKLLDEGSSDGNLDVDGTESSKASKTDAEPSRTSSNLKRSLSGKGKSSKKSKKRKVSDDNNKSEMNQAVVTPATVTSNADHHISITESEAQLALIPSSPLDKNNSQVKTDRSTSKKEKKSRKTKEKESFLNKISDDVDWLKEHHTGLESFIIENLTANLENWNQVKHVQQAPSNNPNLTIEDINRPPAVGYVRVDTNMIHLGQNVWLPKQSYDDAVYNAATNSMFVKNIAMAVFGSQYLKEHSVKGKSCNKTKSKPRPAIDLTKALAVRDIFEYYLKTNKQLIGSNLLSERDTYEDHIRAKISDLLRPPKTSKPKVPKVPPKTMESSSSSYESSVGSDDEKNTEEEMQKEDAAEESSVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HGT4</accession>
    <name>A0A8J2HGT4_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">3-dehydrosphinganine reductase</fullName>
            <ecNumber evidence="10">1.1.1.102</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">HICCMSTLAB_LOCUS9465</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the reduction of 3'-oxosphinganine (3-ketodihydrosphingosine/KDS) to sphinganine (dihydrosphingosine/DHS), the second step of de novo sphingolipid biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>sphinganine + NADP(+) = 3-oxosphinganine + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22640"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57817"/>
            <dbReference type="ChEBI" id="CHEBI:58299"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.102"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="12">
            <dbReference type="Rhea" id="RHEA:22642"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; sphingolipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Sphingolipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.102" evidence="10"/>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5100261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HGT4"/>
    <dbReference type="OrthoDB" id="37659at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047560">
        <property type="term" value="F:3-dehydrosphinganine reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006666">
        <property type="term" value="P:3-keto-sphinganine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030148">
        <property type="term" value="P:sphingolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08939">
        <property type="entry name" value="KDSR-like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000165">
        <property type="entry name" value="3-ketodihydrosphingosine reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045022">
        <property type="entry name" value="KDSR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43550">
        <property type="entry name" value="3-KETODIHYDROSPHINGOSINE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43550:SF3">
        <property type="entry name" value="3-KETODIHYDROSPHINGOSINE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0521">NADP</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0746">Sphingolipid metabolism</keyword>
    <keyword evidence="13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="278"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00026112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00044737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CAG5100261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="317" mass="34740" checksum="5DFDA512136A0B27" modified="2022-05-25" version="1">MLFIIGVLIVIAIIVWLVKELVFPSQRKNIEGKHVVITGGSSGIGKAVAMLAAKMGAHVTIIARDVQKLEASRNDIMSACKNRDSQRIEYLSLDISKDYETIEKSFLDIEKTMGPIYMLVNCAGMAICGKIEDTTIETLNWIINLNFMGTYYCTKAVIPRMKSAKDGIFGYSAYCSSKFALRGLSESLAMEVNPHNVSVTLCLPPDTDTPGFAVEEQSKPLETKLISESAGLVKADVVAKQLIADACAGRFFSTVGFEGFMLTTLSAGMSPVSSLAELFLQFLTMGLMRVVGACYLFSFQKIIKNCMDIRDKNKKSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HGV9</accession>
    <name>A0A8J2HGV9_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">Probable deoxycytidylate deaminase</fullName>
            <ecNumber evidence="17">3.5.4.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">dCMP deaminase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">HICCMSTLAB_LOCUS7989</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="16">Supplies the nucleotide substrate for thymidylate synthetase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>dCMP + H2O + H(+) = dUMP + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:22924"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57566"/>
            <dbReference type="ChEBI" id="CHEBI:246422"/>
            <dbReference type="EC" id="3.5.4.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endomembrane system</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the G-protein coupled receptor 2 family. Mth subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cytidine and deoxycytidylate deaminase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="24">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.12" evidence="17"/>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5095997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HGV9"/>
    <dbReference type="OrthoDB" id="7683403at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004132">
        <property type="term" value="F:dCMP deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008528">
        <property type="term" value="F:G protein-coupled peptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007166">
        <property type="term" value="P:cell surface receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009165">
        <property type="term" value="P:nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15039">
        <property type="entry name" value="7tmB3_Methuselah-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01286">
        <property type="entry name" value="deoxycytidylate_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.10:FF:000021">
        <property type="entry name" value="Deoxycytidylate deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.180.11">
        <property type="entry name" value="Methuselah ectodomain, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016192">
        <property type="entry name" value="APOBEC/CMP_deaminase_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002125">
        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035105">
        <property type="entry name" value="Deoxycytidylate_deaminase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017981">
        <property type="entry name" value="GPCR_2-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000832">
        <property type="entry name" value="GPCR_2_secretin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023311">
        <property type="entry name" value="Methusela_ecto_dom_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036272">
        <property type="entry name" value="Methuselah_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051384">
        <property type="entry name" value="Mth_GPCR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47154">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR MTH-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47154:SF2">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR MTH-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00002">
        <property type="entry name" value="7tm_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00383">
        <property type="entry name" value="dCMP_cyt_deam_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="Cytidine deaminase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63877">
        <property type="entry name" value="Methuselah ectodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00903">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51747">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50261">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13 21" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="14 24" id="KW-0675">Receptor</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="15" id="KW-0807">Transducer</keyword>
    <keyword evidence="5 21" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 21" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="595"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="630"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="668"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="712"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="764"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="816"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="852"/>
            <end position="873"/>
        </location>
    </feature>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="23">
        <location>
            <begin position="95"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 2" evidence="22">
        <location>
            <begin position="590"/>
            <end position="875"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00037036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00038938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00041763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00052978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00071625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS51747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="CAG5095997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="928" mass="106070" checksum="2323AAA90D90CB1C" modified="2022-05-25" version="1">MQHPNPSQKVKINKSLSRSHLSLDMIRKFIHHIQSLILVFIQDTVKAITDKKKKKIREECYKTHMEKRLISFLHIRLYFSSNGGVNLVAKQDYLVDDDFFMGVAYLMAELSKDPCTQLGACIVDERGHIVSTGYNGMPFGCNDDEFPWGKHNEDPLQNKSTFVCHAEANAILNKHSHDLENCTMYLKLFPCSECAKLIVQARIKKIIYTYDEPEKTNSEASKIMFDAAFIEYSVNGFNNNEKCCPPQEIFSVKESSRCFISNNENSPGYYDARNEDWEIKYLKECFNVTSRKSSLNSTIASSITCIDFLRNKDLLDASFIYYCKQDSKNNGASRVMNMRKCCPIGQRYDTEIRECIEFTSGDSSILKVLNSFNVNVNFLSIIKGFPICKYSIIDYIISRDDQLSFDNNTIKISISSNTGAGEISINEDNSCLDFGSSQDTFVLRTCSSSEYCKQNACLRKCCLEDEAWINHQCRKISSFGGSHAHFHSMLKNVMDTTLSNTTSLDVLNSTGYGLMIGQQFCNDSMYSIRPEENWSITSRGYIYVPEQGEYSLDEYCLEMVYESKDYSDGLYPCLCFDGYAGPSEEISSQRFTVNAVLELISCTFLLLTFLVYLCLPLLQNLHGKTLMCHLASLFIAFACHATITLSSLQDSTDGDFIINKPMCKALGYAMAVSFLASFSWLTIMCFDIWWTFGGCSGAAYVSSRKKARKKRFFFYSCFAWGLPMIMLIVMITIDRTKSIPEDLRPNIGVYSCWFDNRLNSYGEVIFFFGPVTFLLIVNVIFFIMTLKNCNRVKADISKFMKTDTDSRRFKADKTKLILNIKLFVLMGISWIFEIISYIINHYAPDLSWRVELFYAFDVLNCLRGLVIFLLFVLKNKVYIALMHRLGRRKINAPINQKAVNLKEPYKMAKYTSSSTLMSSTVDRINAQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HHL8</accession>
    <name>A0A8J2HHL8_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Similar to NME7: Nucleoside diphosphate kinase 7 (Bos taurus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HICCMSTLAB_LOCUS10489</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Cilium axoneme</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the NDK family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5101587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HHL8"/>
    <dbReference type="OrthoDB" id="270127at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005879">
        <property type="term" value="C:axonemal microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04412">
        <property type="entry name" value="NDPk7B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.141:FF:000004">
        <property type="entry name" value="Nucleoside diphosphate kinase 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.141">
        <property type="entry name" value="Nucleoside diphosphate kinase-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006602">
        <property type="entry name" value="DM10_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057579">
        <property type="entry name" value="DM10_NDK7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034907">
        <property type="entry name" value="NDK-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036850">
        <property type="entry name" value="NDK-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037993">
        <property type="entry name" value="NDPk7B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43109">
        <property type="entry name" value="NUCLEOSIDE DIPHOSPHATE KINASE 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43109:SF2">
        <property type="entry name" value="NUCLEOSIDE DIPHOSPHATE KINASE 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00334">
        <property type="entry name" value="NDK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25364">
        <property type="entry name" value="PH_NDK7_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00676">
        <property type="entry name" value="DM10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00562">
        <property type="entry name" value="NDK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54919">
        <property type="entry name" value="Nucleoside diphosphate kinase, NDK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51336">
        <property type="entry name" value="DM10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51374">
        <property type="entry name" value="NDPK_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0966">Cell projection</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DM10" evidence="6">
        <location>
            <begin position="4"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAG5101587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="373" mass="42573" checksum="FA17795169021F15" modified="2022-05-25" version="1">MSDTTERCIFEAEWFDNTAGLLKKFYLYFFPGDNTIELFDIKNKKTFLRRTKCQGVSFKNLFIGSVVTIFSRPMKIIDIADEATRSRLSKTMQKTFGLLRPELLNNLGEILRLITAHDLHIANIKMCRLEECDVEKINKNPRMKCYLASKPVVILMLIGDNAINRWNELICLSDNTSGKPVSLRERFAKDSKDDLFYGSPNIDVAEQELNYFFPNSKLKKHKFQNTATTKNCTCCIIKPHAIQQDLIGNIIEDIQKSGYTISALQQFNIDSIIAEEFLEVYKGVLADHGAMVAEFQSGPCVAMEITHKDPKINVPVEFRKFCGPMDPEIGKQVRPNTLRAKYGKTKIQNAVHCSDLPEDGLLEVEYFFRILDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HHU9</accession>
    <name>A0A8J2HHU9_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Similar to Bub1: Mitotic checkpoint serine/threonine-protein kinase BUB1 (Mus musculus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HICCMSTLAB_LOCUS10439</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
            <location evidence="1">Centromere</location>
            <location evidence="1">Kinetochore</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5101366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="248495at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051754">
        <property type="term" value="P:meiotic sister chromatid cohesion, centromeric"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007094">
        <property type="term" value="P:mitotic spindle assembly checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13981">
        <property type="entry name" value="STKc_Bub1_BubR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.430:FF:000003">
        <property type="entry name" value="Checkpoint serine/threonine-protein kinase BUB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.430">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015661">
        <property type="entry name" value="Bub1/Mad3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013212">
        <property type="entry name" value="Mad3/Bub1_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14030:SF4">
        <property type="entry name" value="BUB1 KINASE, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14030">
        <property type="entry name" value="MITOTIC CHECKPOINT SERINE/THREONINE-PROTEIN KINASE BUB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08311">
        <property type="entry name" value="Mad3_BUB1_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00777">
        <property type="entry name" value="Mad3_BUB1_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51489">
        <property type="entry name" value="BUB1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0137">Centromere</keyword>
    <keyword evidence="2" id="KW-0158">Chromosome</keyword>
    <keyword evidence="11" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="BUB1 N-terminal" evidence="10">
        <location>
            <begin position="49"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="1319"/>
            <end position="1600"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="443"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="558"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="700"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="752"/>
            <end position="909"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1000"/>
            <end position="1068"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1229"/>
            <end position="1265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="444"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="471"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="713"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="754"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="801"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="836"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="856"/>
            <end position="870"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="871"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="888"/>
            <end position="902"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1006"/>
            <end position="1020"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1040"/>
            <end position="1058"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="1229"/>
            <end position="1240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="1247"/>
            <end position="1260"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="1348"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAG5101366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="1600" mass="184782" checksum="8F4CE616A5A82164" modified="2022-05-25" version="1">MDPATVIALCKENIQPLRHGRNAAQLGTALRAQEDAETQQMLMQEKQMYEEAIKNYQGDDPLESWYEYILWVEQSYPKSGHESHIGKLLQQCLATFEKETKYHQDRRYIRLWINYISMQKNPLELYQLLYNTGIGTMVADMYRAWAFELEQVNDCKRADEVYMLGITARAEPRDELIYARENFQMAVGRKALGCDQEKNEIALSEQRQAFSSLRAIKSGKRATNIRTGHRVKDYVPGVVPQSTSSHFYMSAPQIKDGSKSNAKIQIYQDEAAARVDLRCASILDHVPIEDTVHKENTIKPGQWSNLSRKYPLISPSVRPAFKVHEDHLDDDDDDDDDDNNVDNNININYDTLRLFPNHTSFFDGSKYPEHMAVPVFVPDVPSANITKPRYPKDLVYLNNIDRSMEELRAEKYYDRLRNAGNSCSNTDETLLLSGIGQNLNGYTNSNSNINNNNENNNIHHQQNQQNQQQQQHHHHHHHHYQQRESGVSDENFIQKQFELEHHRRALEQNHEIELARQRKQAEIEKQMREAAELEKQQREAAELERQRREIEVERQHREAAELERQQREAAELERHQREAAAAAAAAAAAAAAAEIERQRIEAERIESQRMEAELSRQSKLQSSSYNLHHSSSGVVESGVEQMLGQSLTVNTKEAMSVVQDLWNSPANSNSPLIESPMLHRSSVDSRSKLNFDIHIDSSMTQQHAMSLPRHHPNYNNIQSYHDQENHQPYNSPYNPIQAHHQSYQIPNSYHYPIQQQQQQQQQQQQQQQSIQHLHSPQIQPHIQQQHNMIQQQHHHHHSQIHHQSPIHPPHLQSPHLSHHSQSPNLHTPTHQLQSQQHHHPHPHHHSISPHIPPPQGHHVYNPIHPNPNINYHHHHHHHHHQQHHQHQHQQPQFQQSPMMHHPSMQSESQKQLDFVPFIDPQSDTNKDYRRSELPYIKSPGMNRRDLKYLEKADNKENNTAIDYNSIIEDNKQPVENNLFVDESLGISPLAGANDTCYTESFRGPLPSSTPMTNQFRPSTYRTKDMPHFQPPQLHFVPHVQQQQQQQQQQQQQQQQQQQNSEVQVNDPDDKLSVIMESTREYISSSSGSSANTRTTQFGFTLTTREDHLTIKEQSISQDIESTEALLSANVNTDQNIRTKIQSINTQSPRTMQRNVDQITSEIKNNCDLRIPFNLDRESSIKIDNNKINNDNNKSNSNNISSITTSLTITPINNNTINNSIPNIIDEPMEEAKDDDDDDDDSKNIEPDNNDDDDYDNDDEADKFQLPVGDINPFDKTLISGLLRNIKFPQLRHSDGYARLNININKFVPSSKITLGTDTYELEKCLGKGTYGTVLKAYSPQTEKTVALKTQKPAWVWEFYIAREIKTRLKNPHMLRGFMDVTKAYVTNNGSILVSEFSKYGTLLAVTNQVKIATGKPLTEALAIFFTIEMLQIVEHLHKCQIIHGDIKPDNFLLMHLPTEDVRPTIQLIDYGCSIDMSLFPDGTKFTQIIKTEDFTCIEMRTGRPWTYQTDLYCVAASAHCLLFGTYMRAVQTGDRWFINTKMPRYVQKAWETLFNELLNIESCEKMPDLGELRSLMQEALDKIPALEMKLRSLSNVLKGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HIU2</accession>
    <name>A0A8J2HIU2_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to ORF1: Nucleic-acid-binding protein from transposon X-element (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS11201</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5102822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HIU2"/>
    <dbReference type="OrthoDB" id="7555294at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054722">
        <property type="entry name" value="PolX-like_BBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47592:SF27">
        <property type="entry name" value="OS08G0421700 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47592">
        <property type="entry name" value="PBF68 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22936">
        <property type="entry name" value="Pol_BBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="2">
        <location>
            <begin position="63"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5102822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="479" mass="54928" checksum="433C85F51022E715" modified="2022-05-25" version="1">MVDRASRIELLDKRNYDVWQLRMKSILVKHDRWGYDNNVLYAGNRYGRKPQQRKFKSKNSKPCFICGKIGHWAAKCPERQHNSARSVESSEETHYVVDQPEEAHNVTSRSRWCLDSGCTTHMCVSDKFLTDIQECEMTLNMTNAASTKARAKGLAHIKVKTDTGNIDLNLRNTLLVKDLRTNLISVSKITRNDREILFRKDDAIVRDLNGEVKLAADRIGDLYYLREQAEQVKAVERASERASTSDLDLWHARLRQPTTDTITILTNNLTTHKLVLEILELNKQEHYTYTPKVIKPKSIILKGVNGGFSADMVLTERNSMKLENVKIEKVTEIIFNKINEVKKTTFLIQVSHNSELRELTKIDLLLHQVVKWENLRREKIFQCKKCQRLGHASTNCKLAYRCVKCSGSHGPSACPIKSSDPKSSLKCANCGENGHPANYRGCIYYKHALGLLRNNNSAKIQNYYKQLREISRLIDPNTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HIX7</accession>
    <name>A0A8J2HIX7_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS8703</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5097429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HIX7"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5097429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="115" mass="13681" checksum="BC281D367EAC4A4F" modified="2022-05-25" version="1">MNRDRVYCHTLASLHTYFSVPSPDKIEKIQRECEKDECNKSSDNNKVLNLIQLTVPQCDHYYQRYPQKFYQPKASKHSATQQELLDGVQYIHQHPEYLNQLQIYTANVLHLHFLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HIZ7</accession>
    <name>A0A8J2HIZ7_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNase H type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS9780</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5100707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HIZ7"/>
    <dbReference type="OrthoDB" id="417270at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09276">
        <property type="entry name" value="Rnase_HI_RT_non_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002156">
        <property type="entry name" value="RNaseH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00075">
        <property type="entry name" value="RNase_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50879">
        <property type="entry name" value="RNASE_H_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase H type-1" evidence="1">
        <location>
            <begin position="106"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5100707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="242" mass="27706" checksum="737610B69C900757" modified="2022-05-25" version="1">MELCLKYLATISATPSNPAYQQTTKDFLTEIFRHKPRLPKPLWMRIQHYKEALDINFPPIALRSLGQSPPWQEFTTNMDLSMSEHNRPTTLPSTFRTLFLAIQEKYNNYDEYYTDGSVTTNHSGFAVVTYTNTVNSSRMHNMCSIWTVIYSDSLSALLAIKNQFNVHPLIQHIHKLLEEIAALDIIISFVWVPAHQGIVGNELADKAAKEAITQEIAPNLITAHLDVKKLIKTKIKSQWNHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HJN4</accession>
    <name>A0A8J2HJN4_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Similar to RF_0381: Putative ankyrin repeat protein RF_0381 (Rickettsia felis (Strain ATCC VR-1525 / URRWXCal2))</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HICCMSTLAB_LOCUS10130</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5101057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HJN4"/>
    <dbReference type="OrthoDB" id="439236at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="107"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="140"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG5101057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="440" mass="50689" checksum="4F98D0E077E0640E" modified="2022-05-25" version="1">MEETEKIDNYKRFKKSKILGEKNYDEVCEEIKAGRLSKDVILKIGVEYNYLFWQYDFNDFNSFVIDDQQFSDTVTMSIIHVAIGLNDQAMIDYLLALNCNLQAMTGYGYSVLQFAVMCNKLKAVQKLLDTGVDINDLGEDHQSLLTIAVSWNRYEMVELLISRGAQINDRKSCTFNKSPFGCAVDKSNLIMMKFLISHGADVNLAVSGKRSSWTCTPLMAACILYNSMDLIKFLLNHPYIDIHAVNESNETCVFFAARNAPSGCLQLILNTNIDINTKNIYNKLPLDVIPNGYNNLMNRHIVKLIVAGFYVCEENREAVEDETFDNLRDLCSEEIQLMKDTKELSTNWSCFTILRSSQHTLALRFTHVEVSVDQVKGWIKKFPLYGKILAFHVIKALQRKMILEHTDQVLFDIFKWRLPNTFIHDMFYFLSNYNLSMLLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HK43</accession>
    <name>A0A8J2HK43_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to Sra1: Steroid receptor RNA activator 1 (Rattus norvegicus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS7140</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5093814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HK43"/>
    <dbReference type="OrthoDB" id="5982138at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.940.10">
        <property type="entry name" value="Functional domain of the splicing factor Prp18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009917">
        <property type="entry name" value="SRA1/Sec31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040243">
        <property type="entry name" value="Steroid_recept_RNA_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18834">
        <property type="entry name" value="STEROID RECEPTOR RNA ACTIVATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18834:SF2">
        <property type="entry name" value="STEROID RECEPTOR RNA ACTIVATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07304">
        <property type="entry name" value="SRA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0675">Receptor</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SRA1/Sec31" evidence="2">
        <location>
            <begin position="86"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5093814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="232" mass="25619" checksum="6D0263C30C5F1334" modified="2022-05-25" version="1">MEEKKDEVVSTQKKLQASHDPGWNDPPKWAFTPTPATGSTPTKRLLNKRVAFPLNSSTGPASQSNQVLGSNLPPPMLPSPGPGQVLTSAPHAPLLAPSSITADATSSTVNKQQSLTDSINNFQKIIDSKLENGDKTEEVKRRLDVMKSMWLDDKLNSQIHEKMLELSKALLRNDIETADKIHVFLMTNHTALCNAWISAIRYLILALKDKNFSENANNQPEPILLLNSTEFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HL62</accession>
    <name>A0A8J2HL62_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS9691</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5100618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HL62"/>
    <dbReference type="OrthoDB" id="7694747at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5100618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="164" mass="18472" checksum="DF3E7ED6F1FBA62A" modified="2022-05-25" version="1">MASQKNSYTNLLQTECVPTKDQTVIIDAIDGIQIHKYAIAIGTKIEPENIRHLSRIASNRVCIYVATKEIADTLVVVHKTDKLRDTEVIVRPLISRNKRVILSNVPPIIPSDIILAKLNESKICPVSSITTLRAGLNIPGYQHIMRFRRQAFIKPEDVNKIHTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HLF6</accession>
    <name>A0A8J2HLF6_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS10472</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5101570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HLF6"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5101570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="55" mass="6343" checksum="6975277B576641E2" modified="2022-05-25" version="1">MLDLLDLLDLLDLFDTKREEFCTKIPQQGASQGHEARYKSFHIEKQSLVKLEPGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HLP4</accession>
    <name>A0A8J2HLP4_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Mitochondrial (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS11151</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5102722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HLP4"/>
    <dbReference type="OrthoDB" id="9986315at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.130.20">
        <property type="entry name" value="Mitochondrial ribosomal protein L55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018615">
        <property type="entry name" value="Ribosomal_mL55"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044884">
        <property type="entry name" value="Ribosomal_mL55_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34095">
        <property type="entry name" value="39S RIBOSOMAL PROTEIN L55, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34095:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09776">
        <property type="entry name" value="Mitoc_L55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5102722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="106" mass="12831" checksum="FB256B8B200134A9" modified="2022-05-25" version="1">MLFGKISRGLLLRRQFNCWTANVTKKHRKTYERTYPTVLVYPNGSTINIQYFEPRKIIKLPLDLSVLSEQERKLILERRKPKSKVKIEEEVEDDFDQNKYLRFARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HM66</accession>
    <name>A0A8J2HM66_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Vesicular, overexpressed in cancer, prosurvival protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS13193</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5108350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HM66"/>
    <dbReference type="OrthoDB" id="6629737at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="238"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="298"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="299"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5108350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="320" mass="35508" checksum="23223C65B128BD5B" modified="2022-05-25" version="1">MFVLPLKVSAKFCNGGHDCSPPKECCSLGCCYMYSQPTTPVTEMFAFLIWTYWYLWCVTAKPDLYPLVIGFDEGMGKGTSGFVMRYFRTLSHASTLDSLSSSFMCNVVNEANTIIPPPYSCNNSIDELSTMGCDRVEIGAGESVVSLANNRTTSDISSLAGQSPCSPPRATSPTLELRELLDKIQQLPNEHSSNMINHQNRAQALHSSNINSSLQRPPSPNGECASSRMRRARGKMYMPLGLPNSRNKTKRWLSRSAPTTPSGNIPMALFPGQNMRPSVHDNYNQQVIPLLSEQEETDNINSIENSHNVTSLLREREEQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HMA4</accession>
    <name>A0A8J2HMA4_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Activator 1 subunit 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HICCMSTLAB_LOCUS13268</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the activator 1 small subunits family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5108499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HMA4"/>
    <dbReference type="OrthoDB" id="10254700at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005663">
        <property type="term" value="C:DNA replication factor C complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003689">
        <property type="term" value="F:DNA clamp loader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18140">
        <property type="entry name" value="HLD_clamp_RFC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000028">
        <property type="entry name" value="Replication factor C subunit 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.272.10:FF:000004">
        <property type="entry name" value="Replication factor C subunit 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000129">
        <property type="entry name" value="Replication factor C subunit 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.272.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008921">
        <property type="entry name" value="DNA_pol3_clamp-load_cplx_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050238">
        <property type="entry name" value="DNA_Rep/Repair_Clamp_Loader"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013748">
        <property type="entry name" value="Rep_factorC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047854">
        <property type="entry name" value="RFC_lid"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001679">
        <property type="entry name" value="PRK00440.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11669">
        <property type="entry name" value="REPLICATION FACTOR C / DNA POLYMERASE III GAMMA-TAU SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11669:SF9">
        <property type="entry name" value="REPLICATION FACTOR C SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08542">
        <property type="entry name" value="Rep_fac_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48019">
        <property type="entry name" value="post-AAA+ oligomerization domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="8">
        <location>
            <begin position="41"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00080380"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAG5108499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="327" mass="36824" checksum="D8F8D38C361D32EF" modified="2022-05-25" version="1">MGVDKSGNLPWVEKYRPSTLDDLISHEDIIKTINKFINENQLPHLLFYGPPGTGKTSTILACAKKLYKPAQFNSMVLELNASDDRGIGIVRGQILSFASTGTMYRSGFKLIILDEADAMTNDAQNALRRIMEKYTENVRFCIICNYLSKIIPALQSRCTKFRFGSLNSEQILPRLEHVVKEENIKITEDGKRALMELSGGDMRKVLNVLQSTWLAFGDVTETNVYSCVGHPLPIDIKNIVNWLLNEQYFSAYSKINDLKIKKGLALQDILTQLHLLVNKIEFPDNIIMELIIKLAQIEKQTAAGCNEAVQLNALVSAFQNARDIEKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HML7</accession>
    <name>A0A8J2HML7_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS11096</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5102600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HML7"/>
    <dbReference type="OrthoDB" id="6340174at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006631">
        <property type="entry name" value="DM4_12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21398">
        <property type="entry name" value="AGAP007094-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21398:SF22">
        <property type="entry name" value="IP12060P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07841">
        <property type="entry name" value="DM4_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00718">
        <property type="entry name" value="DM4_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5102600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="286" mass="32228" checksum="5C5601EDBE21F65F" modified="2022-05-25" version="1">MFEVGEFIVMKFLWTVYLGGLYFTFVGVETKGRMSGSLQRQLRELTYPDDSEMGLFFALAIPLDDPVATKAMSVAFFFEANYGLVREQESLASRARKQRATFSDHKLLTRATVYSILESKFEALSIQTGDFNQYLPAPALLLDILIPWPFSKTFFTQPPASIELFAGPNSVISPRLGLSGQACLLRSICETSKLSVDRDNGLIGDLLRILLTPSSSANENLPTEYVLAEQRQLKSRINHHSRCDTGNNHYHHHDPPLDDDDNKELNDCSTIYPLCPISIYDYITIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HP63</accession>
    <name>A0A8J2HP63_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">glutathione-specific gamma-glutamylcyclotransferase</fullName>
            <ecNumber evidence="2">4.3.2.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Cation transport regulator-like protein 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HICCMSTLAB_LOCUS11538</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>glutathione = L-cysteinylglycine + 5-oxo-L-proline</text>
            <dbReference type="Rhea" id="RHEA:47724"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:58402"/>
            <dbReference type="ChEBI" id="CHEBI:61694"/>
            <dbReference type="EC" id="4.3.2.7"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the gamma-glutamylcyclotransferase family. ChaC subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.3.2.7" evidence="2"/>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5103495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HP63"/>
    <dbReference type="OrthoDB" id="1933483at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061928">
        <property type="term" value="F:glutathione specific gamma-glutamylcyclotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006751">
        <property type="term" value="P:glutathione catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06661">
        <property type="entry name" value="GGCT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.490.10">
        <property type="entry name" value="Gamma-glutamyl cyclotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006840">
        <property type="entry name" value="ChaC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013024">
        <property type="entry name" value="GGCT-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12192">
        <property type="entry name" value="CATION TRANSPORT PROTEIN CHAC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12192:SF2">
        <property type="entry name" value="GLUTATHIONE-SPECIFIC GAMMA-GLUTAMYLCYCLOTRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04752">
        <property type="entry name" value="ChaC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00043195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00045227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAG5103495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="191" mass="21421" checksum="A11CB027F5FF170A" modified="2022-05-25" version="1">MVSMKWKLVGYIKGYIRRFYQKSTDHRGVPSKPGRVVTLLASNNPDDQVWGVAYKIATEDIDSVVNHLDFREKGGYERKKVLFYPCNPTAENANNSSRLGLISSADQEEEKPFQLTIYIGHEDNPNFAGAEDIETIASHIIDAHGPSGANTEYLYKLSSAMRTIMPGVIDDHLFALEAAVRRLDDDKNNES</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HPA1</accession>
    <name>A0A8J2HPA1_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS12832</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5107615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HPA1"/>
    <dbReference type="OrthoDB" id="10318229at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032062">
        <property type="entry name" value="DUF4803"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47890">
        <property type="entry name" value="LD24308P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47890:SF1">
        <property type="entry name" value="LD24308P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16061">
        <property type="entry name" value="DUF4803"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5107615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="345" mass="40794" checksum="792EE04948ED109C" modified="2022-05-25" version="1" fragment="single">KKPAEYYLEKELSDDEKSKIIVDDLVGLLENLNTLTDRNYNASRDFVMDQKAFNYVDLLNAFDNVVSKINSYDDILMELRNKFGYNLARYCPVVSNITKNITLEKKGIIFVKYNQLQNLKRYINNYKFYDSCGKRALTEQLFINFYQQMVTTYLKEYVVRYYLDVINRQCPEKNLIRTKMDEFIMINRLQNHINSYNEESKGFLPYLYRCDPPNYDNSNETKYYEFTRMIQASIVKEEDLDIHKSCRHNCDINTIKNSMNLTVCQGYRRCQYVGKSLEICELPDSDQSGRKYQWFKNSEGLFCGDNSTECKTPVKTVSSILSLSNFCSFDYCLCTCVKKKIVERR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HPD3</accession>
    <name>A0A8J2HPD3_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF4485 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HICCMSTLAB_LOCUS10335</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5101262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HPD3"/>
    <dbReference type="OrthoDB" id="78101at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027831">
        <property type="entry name" value="DUF4485"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14846">
        <property type="entry name" value="DUF4485"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4485" evidence="3">
        <location>
            <begin position="11"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="99"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="142"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="235"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="107"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG5101262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="480" mass="56362" checksum="29422D6408E311C1" modified="2022-05-25" version="1">MEKYSEQDAKLDEEFNETLHRIRQILKIKSLDDINLCESWLEKLKTAKNQRVLRNKYILELYRLIKAGSLTGIFKEFPSKSVLMSVNYSDEVNPDSVSSVIETSSSESERNSSREIKYPRDQSNGCKASSYKMQLATSKKRIQFLADVVNELHEQNDRLKQKLKKCNTDVSTDFNKIIEKQKFEVEELKSRLEKAEFDGKELEKNHRDIVEQYKGTMLEQISEFKSCLQTEQAKNIQLIDRIAVLTQEVEALKLEKLNEVKCVEKKYFDELESNKSHYETLLKEKEQEIQVQMGIVGQLKEEIFAAARKVQDMEDKLQIKLENENKLQDILTDQYSSIKEEFVKIRNEMQLANEHHQHYLEEKVSKLKKNLLKVEVSKHKMSSQFKRKIFEVLKTKELEITTLQMQIEGQKSGSTNSVTLEKQSEVNNIFNQVQESYKEAWASNEAVVDIQKQQFLQKIIELENQIRNIKNGLMEKEFYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HQ19</accession>
    <name>A0A8J2HQ19_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glutamyl-tRNA(Gln) amidotransferase subunit A, mitochondrial</fullName>
            <shortName evidence="5">Glu-AdT subunit A</shortName>
            <ecNumber evidence="5">6.3.5.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">GatA</name>
        <name evidence="7" type="ORF">HICCMSTLAB_LOCUS13530</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>L-glutamyl-tRNA(Gln) + L-glutamine + ATP + H2O = L-glutaminyl-tRNA(Gln) + L-glutamate + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17521"/>
            <dbReference type="Rhea" id="RHEA-COMP:9681"/>
            <dbReference type="Rhea" id="RHEA-COMP:9684"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:78520"/>
            <dbReference type="ChEBI" id="CHEBI:78521"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.7"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="5">Subunit of the heterotrimeric GatCAB amidotransferase (AdT) complex, composed of A, B and C subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the amidase family. GatA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.7" evidence="5"/>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5108894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HQ19"/>
    <dbReference type="OrthoDB" id="421993at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030956">
        <property type="term" value="C:glutamyl-tRNA(Gln) amidotransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050567">
        <property type="term" value="F:glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070681">
        <property type="term" value="P:glutaminyl-tRNAGln biosynthesis via transamidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00120">
        <property type="entry name" value="GatA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000120">
        <property type="entry name" value="Amidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004412">
        <property type="entry name" value="GatA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11895:SF7">
        <property type="entry name" value="GLUTAMYL-TRNA(GLN) AMIDOTRANSFERASE SUBUNIT A, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11895">
        <property type="entry name" value="TRANSAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 5" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidase" evidence="6">
        <location>
            <begin position="33"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="Amidase" evidence="6">
        <location>
            <begin position="176"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="79"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="177"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-ester intermediate" evidence="5">
        <location>
            <position position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAG5108894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="497" mass="54792" checksum="8D973355786F33BE" modified="2022-05-25" version="1">MNKVLSSPIKQVSSKINSGEIQPTEICKSALKLISLTRPLNAYINVCEDLAQKQASESDKRQQDNKLLGSLDGIPIAIKDNFCVENYPTTCASFMLANFVPGYSATVYNNLRKHGAVLLGKTNLDQFAMGAGTVDSYYGPTQNLWGSNFMENYVSDGIDSIPVVKKADKNHWNIAGSDTGGSTRNPAAYCGLIGLKPSYGLVSRHGLIPLVNSMDVPGILTRNVDDCLLILNAIAGTDQLDSTTLDQSLTPIEIPSTDISVRGLRVGIPNEYNHAELNQEVHNTWMGVSNLLKEAGADVVPVSLPHTEYSIVCYSVLNQCEVASNMARYDGIEYGLRADESMSTERLYSKTRSLGFNNVVRSRILTGNYYLLSENYNDYFVKAMKARRLIAQDFDAVWNDNIDILLTPTTLSDAPIYKDFISQDNQTQCSVQDYCTQPANMAGIPAINVPISLSKKGLPLSLQLMAPFLHEQRLLTVAKWLEDAVKFPRIYLKESCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HQ86</accession>
    <name>A0A8J2HQ86_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS11075</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5102558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HQ86"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5102558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="67" mass="7523" checksum="5A43EF301D6AFBFB" modified="2022-05-25" version="1">MTTHLIFYTEIIIKIPTSLSDPALAYQSIGPGSSPAYTNEYFHYLSVLFCSAQEIKRVPISKVYPLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HRD9</accession>
    <name>A0A8J2HRD9_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">glyceraldehyde-3-phosphate dehydrogenase (phosphorylating)</fullName>
            <ecNumber evidence="4">1.2.1.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HICCMSTLAB_LOCUS13533</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>D-glyceraldehyde 3-phosphate + phosphate + NAD(+) = (2R)-3-phospho-glyceroyl phosphate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10300"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57604"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="1.2.1.12"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 1/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.12" evidence="4"/>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5108897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HRD9"/>
    <dbReference type="OrthoDB" id="1152826at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00184"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004365">
        <property type="term" value="F:glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019682">
        <property type="term" value="P:glyceraldehyde-3-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd18126">
        <property type="entry name" value="GAPDH_I_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05214">
        <property type="entry name" value="GAPDH_I_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.360.10:FF:000001">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000266">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020831">
        <property type="entry name" value="GlycerAld/Erythrose_P_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020830">
        <property type="entry name" value="GlycerAld_3-P_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020829">
        <property type="entry name" value="GlycerAld_3-P_DH_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020828">
        <property type="entry name" value="GlycerAld_3-P_DH_NAD(P)-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006424">
        <property type="entry name" value="Glyceraldehyde-3-P_DH_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01534">
        <property type="entry name" value="GAPDH-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10836">
        <property type="entry name" value="GLYCERALDEHYDE 3-PHOSPHATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10836:SF76">
        <property type="entry name" value="GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02800">
        <property type="entry name" value="Gp_dh_C"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00044">
        <property type="entry name" value="Gp_dh_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00078">
        <property type="entry name" value="G3PDHDRGNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00846">
        <property type="entry name" value="Gp_dh_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00071">
        <property type="entry name" value="GAPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyceraldehyde 3-phosphate dehydrogenase NAD(P) binding" evidence="10">
        <location>
            <begin position="2"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="Glyceraldehyde 3-phosphate dehydrogenase NAD(P) binding" evidence="10">
        <location>
            <begin position="271"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAG5108897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="602" mass="65192" checksum="2A17E0A85418E347" modified="2022-05-25" version="1">MLTVGINGFGRIGRMCLRVCLENDIDVRLINDPFISTDYMLYLFKYDSTHGTYPSIMVCEKAALVIGNKKISTSQEKNPSKIKWNNHGVYFVIEATGVFTSLEKASMHLDGGAKRVVITAPSDAPMYVIGVNHCSYTPKKGYVVSAASCTTNCVAPVLKVMNDNFQVLEAMITSIHATTATQKTVDGPTGKARLLCSHYSHLPQKTTSYDEVKTAMKKAADGELRGIMHYTEDDVVSSDFNHTKYSCVFDAKAAIPQTGTFIKVVVWYDNDKIGINGFGRIGRLVLRASIDRGATVVAVNDPFIDLDYMVYMFKYDSTHGKFKGTVEAKDGNLIVNGNKIMVFNERDPKAIPWSKAGAEYVVESTGVFTTIEKASAHLEGGAKKVIISAPSADAPMYVVGVNLDSYDPSHKVVSNASCTTNCLAPLAKVIHDNFEIVEGLMTTVHATTATQKTVDGPSGKLWRDGRGAAQNIIPAATGAAKAVGKVIPALNGKLTGMAFRVPVANVSVVDLTVRLGKPATYDAIKAKVKEAAEGPLKGILGYTEDDVVSSDFIGDNHSSIFDAKAGIPLSDGFVKLISWYDNEFGYSSRVIDLIKYMQSKDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HRN7</accession>
    <name>A0A8J2HRN7_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Similar to oig-4: Immunoglobulin domain-containing protein oig-4 (Caenorhabditis elegans)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HICCMSTLAB_LOCUS12000</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5104434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HRN7"/>
    <dbReference type="OrthoDB" id="6127080at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000032">
        <property type="entry name" value="palladin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050958">
        <property type="entry name" value="Cell_Adh-Cytoskel_Orgn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45080">
        <property type="entry name" value="CONTACTIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45080:SF8">
        <property type="entry name" value="IG-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035219941" evidence="4">
        <location>
            <begin position="25"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="5">
        <location>
            <begin position="50"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAG5104434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="162" mass="18493" checksum="F86CF8654B487730" modified="2022-05-25" version="1">MARAITIALLLVVILMISCPEIEARRGKTRARSKSRVQIGLPITGKYRDPESDQYYNNNNGAKILLASHFDLEYVLGHKIAFLCVARGSPRPHITWFKDGAEIYTHLYLHVHEWELKNDTVKSKLEIDPATQMDAGVYECTADNMYAIDRRSFKTDFSIAFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HRV6</accession>
    <name>A0A8J2HRV6_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Similar to akirin: Akirin (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HICCMSTLAB_LOCUS13822</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the akirin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5109186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HRV6"/>
    <dbReference type="OrthoDB" id="10039914at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045089">
        <property type="term" value="P:positive regulation of innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22240">
        <property type="entry name" value="akirin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024132">
        <property type="entry name" value="Akirin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13293">
        <property type="entry name" value="AKIRIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13293:SF6">
        <property type="entry name" value="AKIRIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="13"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="77"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="17"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="34"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="81"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="97"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAG5109186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="159" mass="17785" checksum="E3DCA27E19EFB27E" modified="2022-05-25" version="1">MACATLKRSLEFDPVHSHGRPNKRRRCAPMCVSPGSSTQRTSSHQNPSPFGEVTHKLTPEKMAANIREEICRLHKRKQLHFNPQGNSSGCDSSDMEGGPASPSGCGSSSMLKEQETQIREEYDQILTMKLSEQYDAFVKFTYDQIQKRFESAAAPSYLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HS28</accession>
    <name>A0A8J2HS28_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS12286</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5106490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HS28"/>
    <dbReference type="OrthoDB" id="6263678at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="126"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="197"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="423"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="607"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="197"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="222"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="434"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="607"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="667"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="693"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="705"/>
            <end position="720"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5106490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="812" mass="92523" checksum="8290A61C0175CDC1" modified="2022-05-25" version="1">MTTCCRTSDIKSSVYNQKGESYFEQLAAYNRMSAHLRRVLLAKSRVDSRNESYMLKKRSISAGKVKFIPSPPQEFIDRVAYDTEHHPLDVLRMGYSVTDYTRSKTPKKCPAACSVWEDDCPKARSNLTRTSESERGRSLSRSRPRYSSGLSFHSARPGSFTKRNSKNYDKNQELEEENNDEEIEGCYGGKCNEYSVNSSNRSSPSRSAKSKGDNDHAGSAYESSFESPSEGSHSRRNSAASKDSASSRSNENSLLSTRKRDIEACRVVNVSDEIKYSKFLYDITQEIVQNGYYKDEELRIDHYDEDEEERIEKFIKSQKYLSVSPLKPPTPPKILDENKMTDKLMNPEELKEAYSKSPHSGRNTVVLVDANPELLITERDVLATLMEMNIDPDQAHRVYKRLLKRSKDLHTLQMVKKTIGQVHARRKDAGISPIASSTRTQGFRSRSTQPNDYHQHQLHTQYQYDIRCGETSKRDFNGSQIQLFTSTDDSLKIQPPLCFCSKKNLSTVQNDGSKTKAKECFCKSRLRNKSPCEILSSISAKKKQMEKMINQTKLNPKRCYCPKKEFKDSRNKIESNKSAPEVKVKIKDNKNSRKINLREEESIKFKQRTKRFELSSRESVDKDVEVKNSQEESGTDDSSASRVTRLSFPAVRGPGEGGLDVTSKLSLDMEKSGTKEIKSSVTADGSTGREFQLSPSNYDSNNQDTDQESIAESYSDVEDSSEVKDKDDIKIEAQFFRDDARRELLINKEVPELESKQSRKRQICSSHTNYNSKRMHTQVQIQDSHLHGCATVCPNLPQKKINTLCKSCEMSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HSD7</accession>
    <name>A0A8J2HSD7_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Odorant receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HICCMSTLAB_LOCUS13607</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cell membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the insect chemoreceptor superfamily. Heteromeric odorant receptor channel (TC 1.A.69) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5108971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HSD7"/>
    <dbReference type="OrthoDB" id="7663575at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005549">
        <property type="term" value="F:odorant binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004984">
        <property type="term" value="F:olfactory receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004117">
        <property type="entry name" value="7tm6_olfct_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21137">
        <property type="entry name" value="ODORANT RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21137:SF43">
        <property type="entry name" value="ODORANT RECEPTOR 47A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02949">
        <property type="entry name" value="7tm_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 9" id="KW-0552">Olfaction</keyword>
    <keyword evidence="7 9 10" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="8 9" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="48"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="80"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="143"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="209"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="280"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="311"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU351113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAG5108971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="406" mass="47727" checksum="DF8931C835C1C331" modified="2022-05-25" version="1">MFRKKIKNSVMTFEEIWSIEFGVFKLIGISLGNALVGENCKPSLLHWFKFISGVSILNIFVFICINTLNDDRFDDIYHAAEVFSLILSVLLSIIKASALWIYQRNLLEIIKDFHNLWSYSETKLTSKNDLNSFMKRSKIMIKCYCYAIVSLGSSYALRPYFTILINYVKILFNASSHINNSITIFPIKYPLDSDAMYKYILLALYEQWVVYYGLIFWTACDILYIQLITNLILSDDIRSLNRFRNTEYNYNVQYFITRIVERHRYILSIFYKVNTLYRPIFTFTLLLNGVDLCCCIFTLDKEFSSGHWSKVGRSFAHASTLFIQIIIYCNYSHQATEMTLKLSDSIYGLKWEDYDVKLVKMLIMIMIRANKRFKFSAYGVVDLNRPHMTQIIKRTLGYLTLLRSFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HST4</accession>
    <name>A0A8J2HST4_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">EKC/KEOPS complex subunit GON7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS12678</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5107296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HST4"/>
    <dbReference type="OrthoDB" id="6514241at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="149"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="160"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5107296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="187" mass="21589" checksum="376099DAEBD0D25C" modified="2022-05-25" version="1">MNDFNATLRNLNTFIYVRTRTKQRYSVGFGKGGLPSLGSGYVTIDNDDNANYNKHEIFDYSHLTHEGPKLKKQIKYETILFKFYFIYILQIIKKKMEPSIKVEVTTNNECIFNNSINISNYHKIDNLIENLKVMQRQVNDFLTTLVEKDSGKGESQELSSGDDEEDSDDADTIDTKKCKFKPTGFNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HTI6</accession>
    <name>A0A8J2HTI6_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Similar to Sms: Spermine synthase (Mus musculus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HICCMSTLAB_LOCUS13165</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the spermidine/spermine synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5108293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HTI6"/>
    <dbReference type="OrthoDB" id="5953636at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016768">
        <property type="term" value="F:spermine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006597">
        <property type="term" value="P:spermine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000197">
        <property type="entry name" value="spermine synthase isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030374">
        <property type="entry name" value="PABS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030373">
        <property type="entry name" value="PABS_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015576">
        <property type="entry name" value="Spermine_synthase_animal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46315">
        <property type="entry name" value="SPERMINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46315:SF1">
        <property type="entry name" value="SPERMINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01564">
        <property type="entry name" value="Spermine_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01330">
        <property type="entry name" value="PABS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51006">
        <property type="entry name" value="PABS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0620">Polyamine biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PABS" evidence="4">
        <location>
            <begin position="139"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAG5108293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="324" mass="36316" checksum="11ACB30F8F054D37" modified="2022-05-25" version="1">MVAHTVLLDFTVSSNVIADVDKRSNLKSTIVNVLSDYFNGIKPLTEVTIDGSFIILYSGPRASLITVRGYPQGLVTVNVEYYKQDEDEPLLSFESTRNLETAMQSAATATRSHTLAPIKRGGPFERYYPTSDMSEADIIYTETLMQKGKECYADKEIVILGGGDGGLLWELLKEKPKHVIMLEIDDVVIKACSQHMRSVCGDCLDKRKGDNYEIIIGDCVEALTHMVEEGRQFDYVFGDLTDLPISPPDGDAWDFIRLILNKTVKVLKSSGKYMTHGNGASCPEALTMFEDELSRLSVPVTFTKDRAFIPSFFEDWIFYQVSRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MBP8</accession>
    <name>A0A8J2MBP8_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Similar to Rbm12: RNA-binding protein 12 (Mus musculus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HICCMSTLAB_LOCUS3472</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5082162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MBP8"/>
    <dbReference type="OrthoDB" id="2588702at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12510">
        <property type="entry name" value="RRM1_RBM12_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12254">
        <property type="entry name" value="RRM_hnRNPH_ESRPs_RBM12_like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050666">
        <property type="entry name" value="ESRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13976">
        <property type="entry name" value="HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="472"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="714"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="902"/>
            <end position="978"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="114"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="334"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="437"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="556"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="125"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="171"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="190"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="369"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="566"/>
            <end position="580"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAG5082162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="978" mass="109482" checksum="BB3D6806EF576135" modified="2022-05-25" version="1">MSVIIRLQNLAWSANALDIRQFFRGLSIPEGGVHIVGGELGDAFIAFSTDEDARQAMMHDGGKIKEMKIKLLLSSRTEMQKVIETARQQTLSLQSFMQNSVPVPGVPVMNQHMQPQHQLQIKPPQEVKKEEDSKDRKDRRDRSRSRDRSRSRDRDRGRDRNRDRRRRDRSRSRDRDRDRRDRGSRRRRDNSRSRDRTRSRDRDRDRDSKRYSDRRNKDSQQDNDDTSDVVCVGQFSKDKAMLGKNSKRQHPTIENGIWEVPPQTQMQMMLAPGILGAGIAAIPHQDSESRALGFPAVPGVCPPPLMPGQFPLNNGLNLNMPGINNSNIAAINRERHSWPGNPSPGGNELPRLNEMRFPPRPPGNFGSENFSNSSNNTANNSNNPNNNNNNNNNNNSNPSSNNNPRDYNNSNNYRNNLRNNSANLSLMTKMQELDGRRNPHAFQSSNYSDPYPSERDRSNLGNNGRFDGKGGNCIEVRNMPLNASYSDIRHAFQGIFIRKDGLKLINDTHGNRVGIAYIKFSKPEGKELAMNTPRFIRGSEVEICSLDESIFDKAVDSYNPERDGPSNNSSNNLINSSSSSNININNNSNSSVEDLPPDTQNSSCVFINELPSFAKEMDIAKMFQDWKINDLFITSSTALLSTSSKSDSVQVGAFVQFSRVEDAKAALASSLKIGPIPITAISIPEDKFVKAKRIHEQETLSNNSSNTDSGNTPDCIIIRGLPFQTGDRDILDFFSDIGIVPRRIHMMVNKHGTPMGECFCEFDAPEEAIRALAKNGLPLGKSFPTVELVSRHKMLDTLGNPESSGASGQWMDPQQNFPFSMHDSGSRPRGPQMMNYHSPRFNNGFGMRGLPPPPPPPPGIINMSLRPLVPGLTSGSGSNSGNSSGNRLPAMDYVEGFGKPGCVLSLENVPFKADINEIIEFFGDFDIKREHVIRRYNERGMPTGDARVAFSSPSEAQRALRELRNCKVRDRTIYMKLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2ME93</accession>
    <name>A0A8J2ME93_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidyl-prolyl cis-trans isomerase</fullName>
            <shortName evidence="4">PPIase</shortName>
            <ecNumber evidence="4">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HICCMSTLAB_LOCUS4400</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="4">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 4">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the cyclophilin-type PPIase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="4"/>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5087025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2ME93"/>
    <dbReference type="OrthoDB" id="193499at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016018">
        <property type="term" value="F:cyclosporin A binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.100.10:FF:000025">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase CYP19-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024936">
        <property type="entry name" value="Cyclophilin-type_PPIase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020892">
        <property type="entry name" value="Cyclophilin-type_PPIase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071:SF561">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001467">
        <property type="entry name" value="Peptidylpro_ismrse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00170">
        <property type="entry name" value="CSA_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0697">Rotamase</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035342282" description="Peptidyl-prolyl cis-trans isomerase" evidence="4">
        <location>
            <begin position="22"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="5">
        <location>
            <begin position="36"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAG5087025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="155" mass="16989" checksum="A71970F44432FB01" modified="2022-05-25" version="1" fragment="single">MKFLLLLSVFGLSALLGNVSADDKTAKGPKVTQVVYLDLKRGDEDLGRVRIGLFGNTVPKTVKNFVELAQKEKGQGYKGSKFHRVIENFMIQGGDFTKGDGTGDENFKLKHYGAGWLSMANAGKDTNGSQFFITTVKTPWLDGRHVVFGKVIEGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MEX0</accession>
    <name>A0A8J2MEX0_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Similar to Gpkow: G-patch domain and KOW motifs-containing protein (Mus musculus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HICCMSTLAB_LOCUS4671</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5087986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MEX0"/>
    <dbReference type="OrthoDB" id="5577072at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000467">
        <property type="entry name" value="G_patch_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045166">
        <property type="entry name" value="Spp2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026822">
        <property type="entry name" value="Spp2/MOS2_G-patch"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15818">
        <property type="entry name" value="G PATCH AND KOW-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15818:SF2">
        <property type="entry name" value="G-PATCH DOMAIN AND KOW MOTIFS-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12656">
        <property type="entry name" value="G-patch_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00443">
        <property type="entry name" value="G_patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50174">
        <property type="entry name" value="G_PATCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="G-patch" evidence="4">
        <location>
            <begin position="229"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="83"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="359"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="83"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="359"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="446"/>
            <end position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAG5087986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="461" mass="52923" checksum="AA7609CBB6276A2C" modified="2022-05-25" version="1">MTQENKKISFGFSRQSSRQPLLKAPTEAKVKDGKDYIKCIDNKSIKLINETKVVNGPLVIPLIESSNSWKNKLIEKLNSKDVNTSSESSKKLNSTEASSKNFNSTSENSNSPAPVLKNSVAASDNLKSSSSKEEIEIIDVEKIEKVVEVIEIEENDEEEMEISNVSKLNKVEIDEKEWDRLAAEEILKDSQKKIKVEKGSDFKIEISESNMLFVGEEESTLDDYERIPIDQFGMAMLRGMGWHPDRGIGKKPQLVTTEVPLSRPRGMGLGADKVVKKPSSSGDSKKELKLEKGCFVKLIAGRLMGHYGEVKGFDEDKGRVMVKLSLLDDVQTFSEVMLDPVSKDEFDKNSKVINISKYEEYKNKTQDLEDGRSRVNGHVERERDDDRRDVSYSSRDKRRDRERSRSKERSRGGKNKYERRDRDRSRSRGRENKHERRDRGRDRSGERHKHKKSKHHKKHRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MGN2</accession>
    <name>A0A8J2MGN2_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Mitochondrial (Bos taurus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HICCMSTLAB_LOCUS2836</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein lipoylation via exogenous pathway; protein N(6)-(lipoyl)lysine from lipoate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the LplA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001117">
        <property type="protein sequence ID" value="CAG5078779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MGN2"/>
    <dbReference type="OrthoDB" id="201621at2759"/>
    <dbReference type="UniPathway" id="UPA00537">
        <property type="reaction ID" value="UER00595"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017118">
        <property type="term" value="F:lipoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009249">
        <property type="term" value="P:protein lipoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16443">
        <property type="entry name" value="LplA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000045">
        <property type="entry name" value="lipoyltransferase 1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.50">
        <property type="entry name" value="CO dehydrogenase flavoprotein, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004143">
        <property type="entry name" value="BPL_LPL_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004562">
        <property type="entry name" value="LipoylTrfase_LipoateP_Ligase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00545">
        <property type="entry name" value="lipoyltrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12561">
        <property type="entry name" value="LIPOATE-PROTEIN LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12561:SF3">
        <property type="entry name" value="LIPOYLTRANSFERASE 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21948">
        <property type="entry name" value="LplA-B_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51733">
        <property type="entry name" value="BPL_LPL_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BPL/LPL catalytic" evidence="3">
        <location>
            <begin position="46"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG5078779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="369" mass="41951" checksum="C7B14100876AE648" modified="2022-05-25" version="1">MLRFRPSVRFFCSRSLEIKKSVFISQSQDIFTNLALEDWLYRNYDLSKNHVLLLWKSNPCVVIGRHQNPWMEANVQTLEEKNINLVRRNSGGGTVFHDHGNLNLSFLTTREKYNRRYNLEIITRALYRHWGIQSHINKREDIVVQGDYKISGTAAKLGRPNAYHHCTLLISSDKKILKVALEKKEMGIVTNATESTRSQVKNLKEINSRVSFDELVNAVGWEFLRTDPLVVKDGGESLVAKQKGFQMVNPTEDWFPGLNKLISEFRSWDWIYGKTPSFTVNRLLKLPCSGNSSSDLVNLTLTVEKGIIEDIKMSLPSDLTSSASSEASVISNLRGTRYHHKVIDKIIAALGCIAIVPSQCEQIDNIALQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MHL2</accession>
    <name>A0A8J2MHL2_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">EGF-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS5425</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5089911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MHL2"/>
    <dbReference type="OrthoDB" id="504708at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006149">
        <property type="entry name" value="EB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39069">
        <property type="entry name" value="ECDYSONE-INDUCIBLE GENE E1, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39069:SF8">
        <property type="entry name" value="FI17111P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01683">
        <property type="entry name" value="EB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EGF-like" evidence="1">
        <location>
            <begin position="130"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="1">
        <location>
            <begin position="228"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="1">
        <location>
            <begin position="270"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="1">
        <location>
            <begin position="368"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="1">
        <location>
            <begin position="430"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="1">
        <location>
            <begin position="562"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="1">
        <location>
            <begin position="687"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="815"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5089911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="815" mass="91287" checksum="EDF0257F846F78F8" modified="2022-05-25" version="1" fragment="single">MGESKCVPLLGGFCFKDYDCIINNSSCIDNKCQCQKNLMAFNENECTECKFILHSEKEFLLKKMDATSSVFYGFDEDDSDNGNSCAYFDGRPCDPKAENPCCDPVQKCTIAVKNDRWSYQCKQKASLGQNCTSDFDCEKDLYAECSNADVCVCNENYVMKNKSRCEQLLGGQCYHDESCNIDNSACIENKCQCNPSFRNPDKYKCLPSGCIMTQILGQRQLRTKLGNQCKTDSDCGEVRHTKCSDNHECVCAENQIMVNKATCLPLLDGFCTNDSPCFVKNSVCINNECQCQDGYVPLSHNQCTAHCHPHLSFPCCESNNKCTKIFEWSVKRHISVCLKPVLLGDSCQTDLDCLTVKNSWCNQNKKCECVNNSVQHNPSTCSSLIGGHCLTDDDCLILNTVCTDYLCTCKPSFVYRPQDQCIPNISLGSSCEHNDDCDDPGHSECSEDKICVCKPRRFIKHNTCQPRLATHGTFCQSDDDCALIKYMKCSENNKCVCHDKTILINNTTCAPILGAPLRKSCVDTLDCDDIWHMKCSENKTCICKANHIEVNQALCKPLLGAICHSNECGVNNSVCVDYECQCKPSFRRDISHSTCSANYKCVCQENHVAIINNATCEPLLGGLCETDEVCRTEHSVCINNRCQCTNRKLDSPCKRSLDCTGVDFTECNINNNRCQCIENFVKINNSTCSPVIKGFCSNHEDCNVVNSICDNNYCQCKPKFFQKNSTHCVEIYNTPIKILKNNFLINFKTCNVNFAILRESCKTDNDCSDILHAKCSLDKKCICRDNNVVTNEAICSPLLGEFCWRNELCAVDNAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MI74</accession>
    <name>A0A8J2MI74_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ribosome biogenesis regulatory protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HICCMSTLAB_LOCUS4357</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in ribosomal large subunit assembly.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the RRS1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5085371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MI74"/>
    <dbReference type="OrthoDB" id="28455at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007023">
        <property type="entry name" value="Ribosom_reg"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04939">
        <property type="entry name" value="RRS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="278"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="286"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU364132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAG5085371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="486" mass="55506" checksum="D9D8674BF32D566C" modified="2022-05-25" version="1">MEVENTEKDVSIDVGTLCVFDDTPVDIQSLKSNGSDYLKLLTQSNTQFLINRIWELPVKRVDESIVAELPKPQTSLPRGRVVPKPKPLTKWEKFAKEKGIRKQKKGKSKLEWDEELGKWIPLFGYKKNKSLEQKDWCVEINGKDDNPIQAALKKKEERVSKNELQRLRNIAKANDIKLPKVGLPSDEKFSSSKQLAVATTVARVSTASVGKFQGKLPKEKDAKDKLLHQVPGLIKKRKAVAMNPIDERKINASLVNDIINKKTSKDIVNVQTAAQVIRQEDSEHSARKKGKKVAGSKSGKKPKADLFEREQHITLENFKSSLKEITKSAKYYLGTIDNPIYKSYKNCDPESWKEGEHYIRVKNYVAYYDPSITWDVNRGMVNMTNVDPEYECNPVRAYWDTKNPKGVVYSMACPYTFEYNYSKEKFCPKVNRDYVLPVHNKMSSSCIENKDNKLQKLCACGLSSDIWDSVNTLSLRQFLVDTTKDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MIM8</accession>
    <name>A0A8J2MIM8_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein arginine N-methyltransferase</fullName>
            <ecNumber evidence="6">2.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HICCMSTLAB_LOCUS4702</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA).</text>
    </comment>
    <comment type="function">
        <text evidence="5">Essential arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA). Specifically mediates the symmetrical dimethylation of arginine residues in the small nuclear ribonucleoproteins SmD1 and SmD3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. PRMT7 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="6"/>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5088071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MIM8"/>
    <dbReference type="OrthoDB" id="412876at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042054">
        <property type="term" value="F:histone methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016274">
        <property type="term" value="F:protein-arginine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000070">
        <property type="entry name" value="Protein arginine N-methyltransferase 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000071">
        <property type="entry name" value="Protein arginine N-methyltransferase 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.160.11">
        <property type="entry name" value="Hnrnp arginine n-methyltransferase1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025799">
        <property type="entry name" value="Arg_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014644">
        <property type="entry name" value="MeTrfase_PRMT7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055135">
        <property type="entry name" value="PRMT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11006">
        <property type="entry name" value="PROTEIN ARGININE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11006:SF4">
        <property type="entry name" value="PROTEIN ARGININE N-METHYLTRANSFERASE 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06325">
        <property type="entry name" value="PrmA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22528">
        <property type="entry name" value="PRMT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036946">
        <property type="entry name" value="Arg_N-mtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51678">
        <property type="entry name" value="SAM_MT_PRMT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein arginine N-methyltransferase" evidence="8">
        <location>
            <begin position="194"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR036946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF22528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAG5088071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="709" mass="80899" checksum="13AFF37B6D39C6DD" modified="2022-05-25" version="1">MLSRLIYNKPKFKLTKMSIFTQTFDPITGCSVWEEKNPNYDYHQEVARSAFADMLHDHERNEKYYLALRKAIDKKHKQGLKANVLDIGTGTGLLSMMAAKCGADTIVACEAFRPMAECAEEIIKNNGFESKIKLIKKKSTEIIVGDNGDMERRANILVTEVFDTELIGEGALPTFKHAHEHLLEKDCIVVPDSGTVWVQVIDSLTVRKWNRINEIKDPKTGRELMKPPSSVNKCAGSSAVHDIQLSQLPREAFVALLAPQPIFRFDWSGKVPLVFNEINTLQCNAIASGTAHAVFMWWDLNMDEDKEILLSCAPVWEHPYTKLEENKGLTMTEMTDKLPWRDHWMQAIYYLPEEIPIKMNEQVTLVGYHDGYSFWFNLPVSNESKLKFTKSPVCDCSLHIAYSRTRLGQLNDCERNEKYISVLKKHITSDTTCLCLSDGSLIGVAAANLGAKKVVLFEPNYLSRRSIEYFIEANHLKDKVEIIESIEQFTCKDYDKSNCLIIGEPYYANSIFPWDNLRFWYLTSAYMKGIPAIPVAAIIRGVVVEFKDLHHIRAPLGVCEGFDLTIFDKLIMSSSEISDHPVEVHPLWEYTGRALSATFDVATFRFEDDFDSESKKEFSGQVPILEEGSCNGVALWIDWSLDSETVVSTGPSKPVVAGQRISWDMNNRQGVHLLRKIQNVNKQNSLSWFFKYHNEDYEYFDFKSSIKFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MJ31</accession>
    <name>A0A8J2MJ31_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS4159</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5084627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MJ31"/>
    <dbReference type="OrthoDB" id="8194903at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004242">
        <property type="entry name" value="Transposase_21"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579">
        <property type="entry name" value="F5/8 TYPE C DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579:SF1">
        <property type="entry name" value="F5_8 TYPE C DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02992">
        <property type="entry name" value="Transposase_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5084627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="803" mass="92919" checksum="88566C7826CBC184" modified="2022-05-25" version="1">MKRGPYKSYLNPGGSGIMPRSTFYGKLKKYRTDIANTNDQISNQNVYDDDDTNANVPSCHKEILVDDSFSIDSAAETDVSSNNQQTLTTTHSLYNSWLFEDFNEQSFHEEIWFDAENSSLIDDHNMDYNNEASEEVNEVKDENFSYHKPLCNCSTITQGEALMMTLALGAEESLPWKTIIAILSMINTLFQNDVVPASKYKLFEILKLNEDILVYHLYCNDCHHYFGAQKKFSKDKFQCPICGDDDDDDDDDDEQSPDICYFLTFDISLQLKSMLEDEEVQKVLMKNILRKNCNNNSNDLRSMRDGEIYKQLSMENNPFSTEYNFSYTFNTGGCKPSTSRKHSVWPIYIYINDLSPKLNSKHMIMAGLWVNKKEPDMLLFLQPFVNEANKLSEKGIEWKLQQQTITSKFIPICASVDSVARCMILNMKEYDGTYGCTFCEHPTECVDNFQKFSMTMIVPKERTDKSIKNQMVQTAEIQEGNDVMGVLGPSPLMNLDYFNIADGMSPDYIDAVLLGVIKEHTEILLSSLGEDYYVGNPNQLEVLNTRLSSFKHPTCITRSPPTLTDRKMWKATEWRSWLLFYSLICFKGILPQKYFDHLAILVEAIHILLSDKINYDELDMALFVSKSFITIKNGPFLQFCERNLTGCLKNIFEIDGCILIDKGKEYYLNDNEQKLVNRLDKCKSFNRIIYNRKRYTSKSYCPWEKIDDSVILLKNDKIGIINNICYFNSHENEKKIYIFYEEVIRLRKYFYSSKNVTVQSIEECIITKNLQFCEVKMILRPCMLTAVQSKHYVIFVPPGCYGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MK28</accession>
    <name>A0A8J2MK28_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Similar to Dido1: Death-inducer obliterator 1 (Mus musculus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HICCMSTLAB_LOCUS8284</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5096587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1884872at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15552">
        <property type="entry name" value="PHD_PHF3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21541">
        <property type="entry name" value="SPOC_PHF3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.5.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.30">
        <property type="entry name" value="Transcription elongation factor S-II, central domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006576">
        <property type="entry name" value="BRK_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037259">
        <property type="entry name" value="BRK_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012921">
        <property type="entry name" value="SPOC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003618">
        <property type="entry name" value="TFIIS_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036575">
        <property type="entry name" value="TFIIS_cen_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11477:SF51">
        <property type="entry name" value="PROTEIN PARTNER OF SNF, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11477">
        <property type="entry name" value="TRANSCRIPTION FACTOR S-II ZINC FINGER DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07533">
        <property type="entry name" value="BRK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07744">
        <property type="entry name" value="SPOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07500">
        <property type="entry name" value="TFIIS_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00592">
        <property type="entry name" value="BRK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00510">
        <property type="entry name" value="TFS2M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160481">
        <property type="entry name" value="BRK domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46942">
        <property type="entry name" value="Elongation factor TFIIS domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51321">
        <property type="entry name" value="TFIIS_CENTRAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="10">
        <location>
            <begin position="905"/>
            <end position="959"/>
        </location>
    </feature>
    <feature type="domain" description="TFIIS central" evidence="11">
        <location>
            <begin position="1258"/>
            <end position="1378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="205"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="600"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="848"/>
            <end position="905"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1228"/>
            <end position="1248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1443"/>
            <end position="1625"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1892"/>
            <end position="1929"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="2115"/>
            <end position="2213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="225"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="277"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="292"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="324"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="613"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="858"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="882"/>
            <end position="901"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1443"/>
            <end position="1464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1471"/>
            <end position="1483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1493"/>
            <end position="1535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="1536"/>
            <end position="1548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1549"/>
            <end position="1579"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1587"/>
            <end position="1598"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="1900"/>
            <end position="1918"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="2115"/>
            <end position="2126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="2158"/>
            <end position="2181"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAG5096587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="2213" mass="246977" checksum="931D806B81AB819A" modified="2022-05-25" version="1" fragment="single">YFTMSSTYIIEPHENEKDSKKDDNFIIVINDDGTMAVDQETLQNLLINKSNANVSVVRVGQTENDGNLTFTVDPSNFEHSDSPITAPSNIDTNLDDPFMAMDPEQLEKLETALQSEEAKQILGENVAAMLDMLTVEEHQNSIRYAVELDHCYTSRSSPLDPEPLDPLPIVNSPENDNTGMINLTMHHQSQSTVFTAIENSTQMTASPVKSIIKTKQPVGRPRKTPISNSQIPNAPKSSNSNVLRNLTTLQLENRKSTTVNQEEENKTNDLSSSTESSDSETSDNDSDFGPRGPRRSGVRARGGRRGLTTRGGSMSATRRRGASKRMDIDQTRKHDSEMAAVVNTMKHSEKSAADDYLSESQLKKQIKINPNQKKEEGSLTHQSSDELLVVPENNLQTTNQAKANLINANMIKGDMILTKPGQLKNQKVYFIKKKVIDKPEDMKSTFTIASKDLNKSANQIQTKLITSQHGKLMAVTPKSIVNNSPQVIQSDADINTIVLPSTQSPAYTQLVQKQLIKSSPVTSSIKIKPTIEVKKDKKKLEGSYEPCPKLEEPLKTISDVKPSDGVKKQIKKDLRKSLGTSVSSLEPALFSTPDIIRRVGSNNESKGHDSNVSFSSGTSISNASGSTLTSSTVVSSDVPFKSNIETLNPEVSAETNNLLSQSLINSDVSTIMFDSDSLEEKSISKLPVTDDLSLDPASQTVINEEIRKSDDSVQNIVSDQNGMEETEHLLATLEMEASKHEEELLAEALLLQEQLDVDLTDTATLDESTNVVPDSLLGTTSFNTEKLSAITTQSFLDETVERVTNIDNLADSHEAEQLKKKNIKEPPSQIFRGGRIITLPPIEAPATRSKKLQVKFESSSKPDDEKKSDKVKKQITQANQIEDMESEIEDDDEEENSDSEDDPNRLWCICKQPHNNRFMICCDVCEDWFHGKCVNVTKTTGKQMEEKGLEWVCPNCTKKKLVQPASTITKSLTIKSPKTESHTQISNTETSLTQSSDGQVEVALNVKQNALSNLAVTQCVVCKKEARSSSIYCSDACILTHAEETSVKDKQVVQSVSSKLKLSLSDTSKSNSEARVIVFEKKTGTVLTGVDAPMASNLKAWLKEHPTFEVARSSNLNILQIGDKMVSAIQTSSPGKMVKPNQQQSKTVQPKMVFTKVVGSKQTVLTSNNKKVTVISNLQNANIISKSGQIKQILVSSNKSQPILKQTTLKNVVNQNKTLPIVIKQTPVKKQEPKCSTPPAKTPQKSLNLKKSEPEPTIRLNVRKTLTELLSTRIKETDDLRLSKEEIENLALKIELEMYKYFRDTGAKYKAKYRSLLFNIKDSKNLTLFRKIADKSLTPDAVVKLSPEEMASQELAEWREKETQHQLEMIKKNELDLMAQAKSIVVKTHKGEQIIENDGGIEAVDPKTPVQDIVTVLNNVDNTSLDTLDEKEDTLSSSFEDVKKIKRNDDKQTKSKDREKEKDGHRSRKNKEHDKDSKKETSSSKRKHRSKDRNRDRRRSKDEKRDKERSRERDRDKDKDKDKNKNKSKDKDRSRKSSKSRSSSHSKSSHKEKQYKDKEKKRNELVDDSKRDESKKKETSPVQTGKLTEDRLWRHVEEETTANTLDGNDSDVSDREPSSTVNLESVDMNDELEKEKDTIIESKSIVIAKDSTKNVSQTVWRGFINMIDVAKFFITAQEVSGQAKELMEDLPDTFEVVGRISHETVWDYISKMKKTGSKEIVIIRFTAANDEEKIPYITLYSYLNSRSRLGVVGNVSKNIKDFYIMPFSSQSQLPPVLFPLNGVGLEEQRPHLLLGIIVQNKRKRLSHNTLSIPLLPKVPKKDSDRSYTPPPVNIATDKLVNSTDVIGEKSTTNQLTVNSFNKTHVGVSRKIIDSATISKIVPELSDKIDLTSSEKPLLEKDDDDEPYSPGDIDDDIDDNLLSPSKNSNELQRKMDEINRQIEEQKQQIQSISSSFLGESVPTLPGLGLDPSDNDLNEAYSPTDVRSFTPPPQGISKFTQPILDKVSNITIPPNLQEILANVKRQECSKFDPYLPSKPSASFLTSINSLNYQKEKTYTPTAVTKESKSTLRSLSDFDLIKKAEEELAAVTPAPIMPVPNMQTLNSVQPFEIANSEFSTSSIDSSESTYPPKLTESVQMSRISEQPKPPGLEDEELPTFPSVTPPTSDAYTLTLQKGVSQSGIMSMKRKVNDDDSPLSHIKTPRVKSRWSQETSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MKJ2</accession>
    <name>A0A8J2MKJ2_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Similar to ssh: Protein phosphatase Slingshot (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS5789</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5090901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MKJ2"/>
    <dbReference type="OrthoDB" id="5779068at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030837">
        <property type="term" value="P:negative regulation of actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043587">
        <property type="entry name" value="Phosphatase_SSH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45864:SF2">
        <property type="entry name" value="PROTEIN PHOSPHATASE SLINGSHOT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45864">
        <property type="entry name" value="SLINGSHOT PROTEIN PHOSPHATASE HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5090901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="151" mass="17172" checksum="7F9B5F80D48098B1" modified="2022-05-25" version="1" fragment="single">MALVTVQRSPSVSSSPQSSCYFAGKGAALVLPPNERARPSRRVSSAGCDIQQHLQSMFYLLRPEETLKMLRKMQILQNIFGGRKRVFISFCGFKPSEDEYIMKEFGIIVMKKKPSVKTGLFKPPSDWEKLTNEAQISYIEMEMKYGIPWGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MMH5</accession>
    <name>A0A8J2MMH5_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Isoforms A/B/D/L (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS8907</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5097847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MMH5"/>
    <dbReference type="OrthoDB" id="10004641at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035263642" evidence="1">
        <location>
            <begin position="27"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="54"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="82"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5097847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="117" mass="13823" checksum="F359A2BFB474F972" modified="2022-05-25" version="1">MVAMRMTYKVKLILLADYLLPSSLLALDYAEDNSDSEELKPFPDQKFIMIKNKYHCQGCPRIFNSECSVKRHLKECGIEPRYQCAYCQYTGKRKFQITRHTKIKHKNQNVEIIDLFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MN88</accession>
    <name>A0A8J2MN88_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Similar to Trl: Transcription factor GAGA (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HICCMSTLAB_LOCUS9529</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5100389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MN88"/>
    <dbReference type="OrthoDB" id="10027872at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048513">
        <property type="term" value="P:animal organ development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003006">
        <property type="term" value="P:developmental process involved in reproduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048666">
        <property type="term" value="P:neuron development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18315">
        <property type="entry name" value="BTB_POZ_BAB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051095">
        <property type="entry name" value="Dros_DevTransReg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015318">
        <property type="entry name" value="Znf_GAGA-bd_fac"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23110">
        <property type="entry name" value="BTB DOMAIN TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23110:SF10">
        <property type="entry name" value="TRANSCRIPTION FACTOR GAGA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09237">
        <property type="entry name" value="GAGA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="BTB" evidence="5">
        <location>
            <begin position="33"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="383"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="140"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="357"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="153"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="178"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="359"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAG5100389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="562" mass="60982" checksum="7FF6CB86ACC08C35" modified="2022-05-25" version="1" fragment="single">MGSSAQLYSLSWGEFSTSLTSAVQLLRGHGDLVDVTLAAGGRTYPAHKIVLSAASPFLLNLLKSTPCEHPVVLLAGVSSDDLESLLEFVYKGEVSVEPSQLPSLLQAAHCLSINGLASPTILTENGEEVPPTAIPTVTEPVTREIMNSSIPINRRKKRRRKSSSSSGKWAKIDTATDTEDRHDGHGDDDRTTDCDQKNEETSVNADDASERSKFSNHRTTNDWITSTGAHIPSSLTVTEVQTALTADNFTDIKPSLQTLMAMQQQYSSLHIPTFSGSLSMALPGFPLPTTSSSTLKVRGASDCPGICPLCGATLRQARNLRRHLLSSCKYRLNSFHTLQQSTDHVVVDIEPKIEIGAFSGQNHGNDSGENGHSKGKSVSDQPTKCPLCGAILRQSRNLRRHLELLHFGAGNNNKPTVRIRRRKHDFQSPTMVPRIHQSQLRTAITNDNSDFSSLNPLSLTSTVSSLSSNFPGNILTPGSEVHPRSEPITAANPLVLGPPNNGLYSSENSASMLNLLPNLPSLSTLPSPHDVFLHEEMLRAGAAAYHDSSRQHIKHMLRENVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MN94</accession>
    <name>A0A8J2MN94_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Repressor of RNA polymerase III transcription MAF1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HICCMSTLAB_LOCUS8271</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Element of the TORC1 signaling pathway that acts as a mediator of diverse signals and that represses RNA polymerase III transcription. Inhibits the de novo assembly of TFIIIB onto DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the MAF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5096561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MN94"/>
    <dbReference type="OrthoDB" id="277029at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000994">
        <property type="term" value="F:RNA polymerase III core binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016480">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1000.50:FF:000001">
        <property type="entry name" value="Repressor of RNA polymerase III transcription MAF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1000.50:FF:000002">
        <property type="entry name" value="Repressor of RNA polymerase III transcription MAF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1000.50">
        <property type="entry name" value="Repressor of RNA polymerase III transcription Maf1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015257">
        <property type="entry name" value="Maf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038564">
        <property type="entry name" value="Maf1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22504">
        <property type="entry name" value="REPRESSOR OF RNA POLYMERASE III TRANSCRIPTION MAF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22504:SF0">
        <property type="entry name" value="REPRESSOR OF RNA POLYMERASE III TRANSCRIPTION MAF1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09174">
        <property type="entry name" value="Maf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037240">
        <property type="entry name" value="RNA_polIII_Trep_MAF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0678">Repressor</keyword>
    <keyword evidence="7 9" id="KW-0804">Transcription</keyword>
    <keyword evidence="6 9" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR037240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAG5096561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="239" mass="26999" checksum="8E9D3A064BD59F09" modified="2022-05-25" version="1">MKLLESTRFEAINSALFIKTGDCKIIGRIESYSCKMAGNDKQMYKRFNSEQGVTPHDLQALSPPQTSLGTSPAQSYFSKSISGDEEGPLCDTISRKTLFYLIATLNSTFCPDYDFSDAKSHEFSKEPSLQWVMNAVDSNLSATAGDHYRNLRSALWAAIEDEISMSECDIYSYNPDLASDPFGEDGCLWSFNYFFYNKKLKRIVFFNCRAINPLYVLDSGVGSDFAMDEDDDDIDNDRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MNC8</accession>
    <name>A0A8J2MNC8_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Similar to Rho1: Ras-like GTP-binding protein Rho1 (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HICCMSTLAB_LOCUS7074</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small GTPase superfamily. Rho family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5093748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MNC8"/>
    <dbReference type="OrthoDB" id="8830751at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032154">
        <property type="term" value="C:cleavage furrow"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000915">
        <property type="term" value="P:actomyosin contractile ring assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001667">
        <property type="term" value="P:ameboidal-type cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022412">
        <property type="term" value="P:cellular process involved in reproduction in multicellular organism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003006">
        <property type="term" value="P:developmental process involved in reproduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035099">
        <property type="term" value="P:hemocyte migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035006">
        <property type="term" value="P:melanization defense response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01870">
        <property type="entry name" value="RhoA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000095">
        <property type="entry name" value="Rho-related GTP-binding protein RhoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003578">
        <property type="entry name" value="Small_GTPase_Rho"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24072">
        <property type="entry name" value="RHO FAMILY GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0488">Methylation</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0636">Prenylation</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAG5093748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="213" mass="23648" checksum="0791D48F01F43F67" modified="2022-05-25" version="1">MGCIVGRSLGPDDTGYPGSGFMAAIRKKLVIVGDGACGKTCLLIVFSKDQFPEVYVPTVFENYVADIEVDGKQVELALWDTAGQEDYDRLRPLSYPDTDVILMCFSIDSPDSLENIPEKWTPEVKHFCPNVPIILVGNKKDLRNDPGTIKELGKMKQEPVKPEEGRTMAEKINAFAYLECSAKSKEGVREVFETATRAALQVKKKKKGKCRLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MPD7</accession>
    <name>A0A8J2MPD7_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Olfactory receptor 34</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HICCMSTLAB_LOCUS10616</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5101714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MPD7"/>
    <dbReference type="OrthoDB" id="6604226at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005549">
        <property type="term" value="F:odorant binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004984">
        <property type="term" value="F:olfactory receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004117">
        <property type="entry name" value="7tm6_olfct_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21137">
        <property type="entry name" value="ODORANT RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21137:SF35">
        <property type="entry name" value="ODORANT RECEPTOR 19A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02949">
        <property type="entry name" value="7tm_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0552">Olfaction</keyword>
    <keyword evidence="8 11" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="9" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="24"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="113"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="166"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="264"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="291"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAG5101714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="387" mass="44475" checksum="6C3D2DC6C29BCCF4" modified="2022-05-25" version="1" fragment="single">LLGIWSLNHSSPGLKLSYYCYKHLSFVMILIFGSTLTADLIINYNDLSVLTDDGCYIAGILVIIFKLYKFNSVHERIKLLVDEIHRPMDTLSRSPDLEARKLIKRTAFLENSMDKFFIVLGCFLAAALTFFVPKQDGALPIRAVFPFDTTVAPMHELAFAVQAFSIFYGLLTIVFMDELIITLIMWINCQLVILRRNYETCGRNIDRSENEDKLLNYTFVMFDETDPSKLEGNFVDKFKYCINQHQRLITVVDHLNEIFSSSMLMQLFASFSMICLTGFQAVLGANEKEHIFKFIIYLGAAFSQLLNWCWFGNELLHKSASLTYGQWSSGWENHINKSLKPLMIISLMRTQKILQLQAGNFYNMSLHTFTAVLKNSYSFFALLTKVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MPH1</accession>
    <name>A0A8J2MPH1_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HICCMSTLAB_LOCUS9651</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5100578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MPH1"/>
    <dbReference type="OrthoDB" id="7696379at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="374"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="188"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="453"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="13"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="27"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="49"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="70"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="453"/>
            <end position="482"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG5100578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="497" mass="57473" checksum="065402869F5BC5F8" modified="2022-05-25" version="1">MEDHDREKELIVDQQSIDQQENPKVSEEEESQEKEESETITVEVHQEDETTEQEASNEEVFDLSIKRDLPSTSQKNTGNDGKNQNDEINKEKKKKSNPKMVRILNVTSLEESINVANKLMTETMVRVTSSMELMARHAANMSDTAILLKKTCEKLNQVTIENMKMASMLTELGGKEVEAIKERNRLLEVNPNFSNPKSESNKRKSNTTQSSPIKRYKNDENQFSKELESIKRSLEQKDLTNAKINIKRDYKLTQKSNFDIWYDYLKSELTSHELLEKNESVVDFCERFDAIVREYETCGSGEPLTAQELRSAFYQAVTPIIPQLRDADLIRRTNSNEMSLEEIKSFILQLEAEKRSESQEVKANRVNTNSKIDKCHRCSKFGHWEKECPLKPKGLWHCYICESVVDHKGTDHNSGSVKLNKRAVMMKDDEIRKQSHEIYQDKKFLESEGVEKNRKMIDHVIGREEVSHASSSKSEESQRESETTETTSEDLNKNEEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MQF6</accession>
    <name>A0A8J2MQF6_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Similar to Kdm6a: Lysine-specific demethylase 6A (Mus musculus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">HICCMSTLAB_LOCUS10542</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the UTX family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5101640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MQF6"/>
    <dbReference type="OrthoDB" id="418911at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044666">
        <property type="term" value="C:MLL3/4 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031490">
        <property type="term" value="F:chromatin DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071558">
        <property type="term" value="F:histone H3K27me2/H3K27me3 demethylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.1370:FF:000001">
        <property type="entry name" value="lysine-specific demethylase 6A isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.20:FF:000002">
        <property type="entry name" value="lysine-specific demethylase 6A isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.650">
        <property type="entry name" value="Cupin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051630">
        <property type="entry name" value="Corepressor-Demethylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003347">
        <property type="entry name" value="JmjC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046941">
        <property type="entry name" value="KDM6_GATAL_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048562">
        <property type="entry name" value="KDM6A_B-like_C-hel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048560">
        <property type="entry name" value="KDM6A_B-like_GATAL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14017:SF1">
        <property type="entry name" value="LD02225P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14017">
        <property type="entry name" value="LYSINE-SPECIFIC DEMETHYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02373">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21322">
        <property type="entry name" value="KDM6_C-hel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21326">
        <property type="entry name" value="KDM6_GATAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00558">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51184">
        <property type="entry name" value="JMJC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="7" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="repeat" description="TPR" evidence="12">
        <location>
            <begin position="74"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="JmjC" evidence="14">
        <location>
            <begin position="752"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="206"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="508"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="559"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="694"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="13">
        <location>
            <begin position="567"/>
            <end position="576"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00034483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CAG5101640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="1064" mass="118402" checksum="0845802447EF6095" modified="2022-05-25" version="1">MYHVVDSSILGVQHKQHKQHKHAFAIHLLQKSIDAEPKSGQSLYLLGRCLAAGNKVHEAFVAYRNSVEKTEGNADTWCSIGVLYQQQNQPTDALQAYICAVQLDKTHSAAWTNLGILYESVNQPKDALACYLNASRSNSNLSSPTTALVGSGGVKSDGNVSMNPSLHQRINFLQSHLSQAPMPSVATKKRPFPSIEEAWNLPISAEMSSRQQQQQPANQAGYKYNATTPSGPPPPYPQGQGPPVTTKRFKAGEEPISAPQPQPQQQQPQQQRPPFYLTTQQLQMLQFFQQNQGNLTQQQQTVLQQLQVQEGQQQAQPGVIKTYGMSQQPQGGTVALQTGFSDSNVAYNTAATGNAQQSPGMPYKSAADSSYTQRAGQYNHYQANQYGTQGYTQITSTTGNYPESSVGSKDINVTDQELHALLSQKDLATTLAEDLLKHFGSEDLDEKEDPIPIMNNGTLSSGPFSPSNLDSERIKEVKVERVDPDCEINSLADSVNNSNINISNRIDSIRSNSSNSTSEPVLKLESLRESPVDPEFSIDMDAKSIIEACKGQGLKGVPNCSILSDRSPPPAPPEPPAQRLTREQLLPPTPSVYLENKKDAFSPQLQEFCLKHPIAVIRGLAAALKLDLGLFSTKTLVEANPDHGIEVRTQMQQTSDENWDPVMSRKVWGCISHRSHTTIAKYAQYQASSFQESLKEEREKSQGIHTANLSDSDSKDSTGVVKRKKNAYGLAGRPGSKMLRFGTNVDLSDERKWKTQLQELMKLPAFARVVSAGNMLSHVGHVILGMNTVQLYMKVPGSRTPGHQENNNFCSININIGPGDCEWFAVPDAYWGVIHNLCERNNINYLHGSWWPSLEDLYDENIPVYRFLQRPGDLVWVNAGCVHWVQAVGWCNNIAWNVGPLTARQYQLAIERYEWNKLQSFKSIVPMVHLSWNLARNIKVSDPRLFELIKNCLLRTMKQCCIILEFVKSKGVEVRFHGRGKNEASHYCGQCEIEVFNILFIREQEKRHVVHCMDCARKQAPSLEGFVCLEEYRMRDLMDVYNGFTLHTTSISSAISAPQSSQTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MQT0</accession>
    <name>A0A8J2MQT0_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Similar to BRIP1: Fanconi anemia group J protein (Homo sapiens)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HICCMSTLAB_LOCUS11586</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5103591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MQT0"/>
    <dbReference type="OrthoDB" id="19182at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990918">
        <property type="term" value="P:double-strand break repair involved in meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045028">
        <property type="entry name" value="DinG/Rad3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014013">
        <property type="entry name" value="Helic_SF1/SF2_ATP-bd_DinG/Rad3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11472">
        <property type="entry name" value="DNA REPAIR DEAD HELICASE RAD3/XP-D SUBFAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11472:SF47">
        <property type="entry name" value="FANCONI ANEMIA GROUP J PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51193">
        <property type="entry name" value="HELICASE_ATP_BIND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="5">
        <location>
            <begin position="159"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="48"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="108"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="78"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="128"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAG5103591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="220" mass="24228" checksum="D73D151B20114796" modified="2022-05-25" version="1">MMSEDDSSDEFQPSKIVISKTSKFFSTNNEAPPTSVLQFPNYNLEVSTDEASLDSSLSPNKRSALLSEEENDDKSENKSNVPPSLQGSSGLFQWQPNKKTQASLHKFLKKRNISPLERESKRQNTNGNDEELMTDDEDDEGKTRIPRLPVPSGHSVMIAGVDVKFPLKPYSSQIAVMNALIRGCSKEQHALLESPTGSGKTLALLCGALAWQEHYALSGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MR01</accession>
    <name>A0A8J2MR01_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">glutaryl-CoA dehydrogenase (ETF)</fullName>
            <ecNumber evidence="11">1.3.8.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">HICCMSTLAB_LOCUS10769</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>glutaryl-CoA + oxidized [electron-transfer flavoprotein] + 2 H(+) = (2E)-butenoyl-CoA + reduced [electron-transfer flavoprotein] + CO2</text>
            <dbReference type="Rhea" id="RHEA:13389"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57332"/>
            <dbReference type="ChEBI" id="CHEBI:57378"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="EC" id="1.3.8.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="9">Amino-acid metabolism; lysine degradation.</text>
    </comment>
    <comment type="pathway">
        <text evidence="10">Amino-acid metabolism; tryptophan metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.8.6" evidence="11"/>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5101946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MR01"/>
    <dbReference type="OrthoDB" id="435240at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000062">
        <property type="term" value="F:fatty-acyl-CoA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004361">
        <property type="term" value="F:glutaryl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033539">
        <property type="term" value="P:fatty acid beta-oxidation using acyl-CoA dehydrogenase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046949">
        <property type="term" value="P:fatty-acyl-CoA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01151">
        <property type="entry name" value="GCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.540.10:FF:000003">
        <property type="entry name" value="glutaryl-CoA dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.10:FF:000006">
        <property type="entry name" value="Glutaryl-CoA dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.110.10:FF:000008">
        <property type="entry name" value="Glutaryl-CoA dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="entry name" value="Acyl-CoA dehydrogenase/oxidase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006089">
        <property type="entry name" value="Acyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052033">
        <property type="entry name" value="Glutaryl-CoA_DH_mitochondrial"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42807">
        <property type="entry name" value="GLUTARYL-COA DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42807:SF1">
        <property type="entry name" value="GLUTARYL-COA DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00073">
        <property type="entry name" value="ACYL_COA_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 13" id="KW-0274">FAD</keyword>
    <keyword evidence="4 13" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase N-terminal" evidence="16">
        <location>
            <begin position="51"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA oxidase/dehydrogenase middle" evidence="15">
        <location>
            <begin position="165"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase C-terminal" evidence="14">
        <location>
            <begin position="277"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00037899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00037927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00039033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CAG5101946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="426" mass="47344" checksum="7D07616B3DE51BDC" modified="2022-05-25" version="1">MAVRAQNNLFKILNGYYSSRSVKCFSVATSKNSKNYTFDWQDPFNIESQYTQDEKMVRDQFHSYCQEKLQPRILDAFRNEHFDKRIMKELGDLGVLCCTLKGYGASGVSSVAYGLITKEIESVDSGYRSSYSVQNLASTAIDSWGSQEQKDKYLPKLVSGDYIGCFGLTEPNHGSDIGSLETRATYDANKKIYKLRGSKTWITNSPVSDLCIVWARCEDDKIRGFIVERKGNEDTLSTPKINGKVSLRASTTGMIVMDDVVVPESNMLPNVTGLRGPFECLNHARYGIAWGALGAAEQCLKIANQYVLDRKQFKRPLAANQLIQKKLADMVSEISIGLQACLRVGRLKDENRAAPEMISLIKRNSAAKAINIARSARDMLGGNGISDEYHIIRHMVNLEAVITYEGTDDIHGLILGRAITGIPAFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MR83</accession>
    <name>A0A8J2MR83_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Acireductone dioxygenase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Acireductone dioxygenase (Fe(2+)-requiring)</fullName>
            <shortName evidence="12">ARD'</shortName>
            <shortName evidence="12">Fe-ARD</shortName>
            <ecNumber evidence="12">1.13.11.54</ecNumber>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Acireductone dioxygenase (Ni(2+)-requiring)</fullName>
            <shortName evidence="12">ARD</shortName>
            <shortName evidence="12">Ni-ARD</shortName>
            <ecNumber evidence="12">1.13.11.53</ecNumber>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HICCMSTLAB_LOCUS11331</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes 2 different reactions between oxygen and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4-methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-one + O2 = 3-(methylsulfanyl)propanoate + CO + formate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:14161"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:17245"/>
            <dbReference type="ChEBI" id="CHEBI:49016"/>
            <dbReference type="ChEBI" id="CHEBI:49252"/>
            <dbReference type="EC" id="1.13.11.53"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-one + O2 = 4-methylsulfanyl-2-oxobutanoate + formate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:24504"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:16723"/>
            <dbReference type="ChEBI" id="CHEBI:49252"/>
            <dbReference type="EC" id="1.13.11.54"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <cofactor evidence="12">
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
        </cofactor>
        <text evidence="12">Binds either 1 Fe or Ni cation per monomer. Iron-binding promotes an acireductone dioxygenase reaction producing 2-keto-4-methylthiobutyrate, while nickel-binding promotes an acireductone dioxygenase reaction producing 3-(methylsulfanyl)propanoate.</text>
    </comment>
    <comment type="pathway">
        <text evidence="12">Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate: step 5/6.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="12">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the acireductone dioxygenase (ARD) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.13.11.54" evidence="12"/>
    <dbReference type="EC" id="1.13.11.53" evidence="12"/>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5103081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MR83"/>
    <dbReference type="OrthoDB" id="1867259at2759"/>
    <dbReference type="UniPathway" id="UPA00904">
        <property type="reaction ID" value="UER00878"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010308">
        <property type="term" value="F:acireductone dioxygenase (Ni2+-requiring) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010309">
        <property type="term" value="F:acireductone dioxygenase [iron(II)-requiring] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019509">
        <property type="term" value="P:L-methionine salvage from methylthioadenosine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02232">
        <property type="entry name" value="cupin_ARD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.10:FF:000031">
        <property type="entry name" value="1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03154">
        <property type="entry name" value="Salvage_MtnD_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004313">
        <property type="entry name" value="ARD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027496">
        <property type="entry name" value="ARD_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23418">
        <property type="entry name" value="ACIREDUCTONE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23418:SF0">
        <property type="entry name" value="ACIREDUCTONE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03079">
        <property type="entry name" value="ARD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 12" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="3 12" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 12 13" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="9 12" id="KW-0408">Iron</keyword>
    <keyword evidence="6 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 12" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="4 12" id="KW-0533">Nickel</keyword>
    <keyword evidence="11 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="12">
        <location>
            <position position="89"/>
        </location>
        <ligand>
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <note>for iron-dependent acireductone dioxygenase activity</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="89"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <note>for nickel-dependent acireductone dioxygenase activity</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <note>for iron-dependent acireductone dioxygenase activity</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <note>for nickel-dependent acireductone dioxygenase activity</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="95"/>
        </location>
        <ligand>
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <note>for iron-dependent acireductone dioxygenase activity</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="95"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <note>for nickel-dependent acireductone dioxygenase activity</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <note>for iron-dependent acireductone dioxygenase activity</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <note>for nickel-dependent acireductone dioxygenase activity</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAG5103081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="184" mass="22127" checksum="9FECE30CA7DB56AB" modified="2022-05-25" version="1">MVQVWYMDDTDSDQRLDHHRQPPKYLSLSELFKRTGVEHFKINPQNYGSDKILQELRSKRGYSYEDEIVCSEECLRDYDNKLKTFFTEHLHTDEEIRLVLEGSGYFDVRDKNDEWIRIKVQSGDLIIIPSGIYHRFTLDMNNYIKAKRYFVGEPVWLPYNRPADEMECRQTYLERLKNNFNAVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MRA7</accession>
    <name>A0A8J2MRA7_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS11391</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5103201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MRA7"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5103201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="62" mass="7223" checksum="470B178377E295CE" modified="2022-05-25" version="1">MSAVESALDVLSRAATMMQERFHCVYISLRYVLFNFEQNYVLKCLDMIRSQFKILGCSSCFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MRY3</accession>
    <name>A0A8J2MRY3_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS12341</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5106601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MRY3"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5106601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="120" mass="13435" checksum="322F286AB517FD99" modified="2022-05-25" version="1">MLQPTIFGTVASDLNPKDGNSRRVSIPTTRSIDLVIWPLRTIVPNYRLTQASFGSLNIVALASNSWPIQCLTSQLSPNKLHFGWIYATDNRPRWTLMPDGDATNGAVADREPSDLSRRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MSK2</accession>
    <name>A0A8J2MSK2_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS11875</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5104184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MSK2"/>
    <dbReference type="OrthoDB" id="7570424at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5104184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="226" mass="26426" checksum="925544AD8171FD74" modified="2022-05-25" version="1">MSDLLNTFTTTNSNAFKWPYQRPLLAIPSQPPENIYRNSNLYLPRIDPDECKCNYHKTDTELTRYKELMGIEHHLCNNVVKVNREITKLVSSMLENSKNDEEVMKSVYQISHQRKDAPLTDYRSLMAAVDAPVGFPIEPDTLELREAYRDPTRFRYSSHDTPAIQPAEPINFKRVPEVFNMWNKPFTGRSEYMDTISKLGLSNLKHYQQHLEPCLSSRRRWGDQSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MTD6</accession>
    <name>A0A8J2MTD6_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="16">CYP4FP3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">HICCMSTLAB_LOCUS9361</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="2">May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 14">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Endoplasmic reticulum membrane</location>
            <topology evidence="4">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Microsome membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 15">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5100054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MTD6"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20628">
        <property type="entry name" value="CYP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050196">
        <property type="entry name" value="Cytochrome_P450_Monoox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24291:SF189">
        <property type="entry name" value="CYTOCHROME P450 4C3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24291">
        <property type="entry name" value="CYTOCHROME P450 FAMILY 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 14 15" id="KW-0349">Heme</keyword>
    <keyword evidence="11 14 15" id="KW-0408">Iron</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 14 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0492">Microsome</keyword>
    <keyword evidence="12 15" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="10 15" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="14">
        <location>
            <position position="450"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CAG5100054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="511" mass="59462" checksum="4FDE54DABBAB6195" modified="2022-05-25" version="1">MDLSTILMTVLMTAFIKLIIYHYRRLDLYRAGSKIPGLEPVLPIIGNAHLLFGETKNVFRKIIILLEKFKVSPVRAWLGHKLCIILFDPEQMKIVLHSPKTIERDELLRFFLPWLGTGLIAAPANKWKVHRKLIMPTFNRRVLEKFIDTINKQCEILVKIMEPEIDKDEFDIFNYISLCTIDIVCETVMGVPSNEQIKKNSAYPAAFEKIMKILYQRMIEVWLHPSVIFNATKLAKDQKECIKSLHKHTNDIIEKKLEQYSKKMNGNAVTQIGFQREAFLDSFTELLFEGTKITIEEFREEVENIMFAGYDTTTTVNSFVILMLAIFPKIQEKCYEELVEIFGDKINGERQIENEDLDRMKYLGRVIKETMRLFPITPLLIRQVNGDLDIGGGYTLPKGSTVFLAIWKLHRSAYIWDDPLCFNPDRFLPEQVAKRHPYAYMPFSAGPRNCIGLKYAMMSMKILLATLLRNYIFMKDKHVNIGDIEIKAEVFLKTIDPITIKMKRRTNTFEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MTF6</accession>
    <name>A0A8J2MTF6_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Palmitoyltransferase</fullName>
            <ecNumber evidence="7">2.3.1.225</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HICCMSTLAB_LOCUS13507</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:36683"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="2.3.1.225"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:36684"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="7">The DHHC domain is required for palmitoyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the DHHC palmitoyltransferase family. ERF2/ZDHHC9 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.225" evidence="7"/>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5108871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MTF6"/>
    <dbReference type="OrthoDB" id="4096362at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001594">
        <property type="entry name" value="Palmitoyltrfase_DHHC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12349">
        <property type="entry name" value="ANKYRIN REPEAT AND LEM DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12349:SF2">
        <property type="entry name" value="PALMITOYLTRANSFERASE ZDHHC8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01529">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50216">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="42"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="143"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="179"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="Palmitoyltransferase DHHC" evidence="9">
        <location>
            <begin position="96"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="280"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="518"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="586"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="280"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="346"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="382"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="557"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="596"/>
            <end position="611"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU079119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAG5108871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="622" mass="69310" checksum="1DBDB1A6A7BEE30D" modified="2022-05-25" version="1">MPGCDVKARYLPATFAWILLLSTTTLFFYYPCQYYLFKYPWVPALQGVIAFFVLANFTLATFMDPGVIPKAPPDEDKEDEFRAPLFKNVEINGITIRMKWCVTCKFYRPPRCSHCSVCDHCIETFDHHCPWLNNCIGRRNYRFFFCFLLSLSCHMLSIFGLCLYFVLEHKEKLGEVDTTIAMVLMGVVTLLFIPIIGLTGFHVILVSRGRTTNEQVTGKFQNGYNPFSRGCFHNCCYTQFGPQFPSLKKPEKYLEKRRGASASEISTIGSENQVKTYMDSSNGVRNASSNAYNKLSPGRDGSDTDMEPTASQSADCEPTPPLQRHGSKSNFFLPPVETNDSPRHPPPQHRHPMHYPRGSPHPRSRGMNGSRSHTPDALSPEGAGSPAAGPQRGQGQGGASPTMQQRIRAIGVPTPLAISSPIRSPQRRFLSESELIRQNNDHPYSRTNNTVDNIRELAGSPQRGVYMWKDNSPSGYPGPPGMGGVNMPGNNIGIPVHPSALSQRPPPPYDYYCSNPTSPTQQPYSTAPRAAYHPASRGGVPVFPPTHQSPQVKRKNPPSMATPTTPTSNDARRRPMSFVRALEMNDSMEMVSIPNDTRSSQRPTTPTPDRTSVYDMNYEISV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MTG9</accession>
    <name>A0A8J2MTG9_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS13537</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5108901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MTG9"/>
    <dbReference type="OrthoDB" id="7701506at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="37"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="114"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5108901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="161" mass="17962" checksum="407005BAE373507F" modified="2022-05-25" version="1">MDFQSAMETFAEAWVAANTKVDPVQSQALALTHKATPPSRSSSVSPIPRSPQSHQTAHATNRSPTPRPASVQHPQLVHQPSQQQGNLIASAGQPRTEHQHQHQHQHQHQHQHQQQHQQAQQQSQQQSFGAHHNRHTKQEIDSTSPKPEGFDLSKNSSVTEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MUT0</accession>
    <name>A0A8J2MUT0_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Sex-determining region Y protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Testis-determining factor</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">HICCMSTLAB_LOCUS13584</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Transcriptional regulator that controls a genetic switch in male development. It is necessary and sufficient for initiating male sex determination by directing the development of supporting cell precursors (pre-Sertoli cells) as Sertoli rather than granulosa cells. Involved in different aspects of gene regulation including promoter activation or repression. Binds to the DNA consensus sequence 5'-[AT]AACAA[AT]-3'. SRY HMG box recognizes DNA by partial intercalation in the minor groove and promotes DNA bending. Also involved in pre-mRNA splicing. In male adult brain involved in the maintenance of motor functions of dopaminergic neurons.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus speckle</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SRY family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5108948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MUT0"/>
    <dbReference type="OrthoDB" id="6247875at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007548">
        <property type="term" value="P:sex differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01389">
        <property type="entry name" value="HMG-box_ROX1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050140">
        <property type="entry name" value="SRY-related_HMG-box_TF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10270:SF161">
        <property type="entry name" value="SEX-DETERMINING REGION Y PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10270">
        <property type="entry name" value="SOX TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0010">Activator</keyword>
    <keyword evidence="5" id="KW-0112">Calmodulin-binding</keyword>
    <keyword evidence="4" id="KW-0221">Differentiation</keyword>
    <keyword evidence="7 12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0726">Sexual differentiation</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="HMG box" evidence="14">
        <location>
            <begin position="143"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="12">
        <location>
            <begin position="143"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="14"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="73"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="39"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00045821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CAG5108948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="238" mass="26396" checksum="C543F5A92366A8FF" modified="2022-05-25" version="1">MSNYQFVVFSGKNKNKSTIKEDVESETEELSINQREVDSSSSSSLSRASSSSSSTSSRKQLIVLTTASDGISNSATIESDSKKRRINNTDKQSSSSRKRDSSVSVSGKILKVDIGQKQVSVDAGASQLGGKYSNSNALGKAKIPRPANAFMLFANEWRRKLANENPRESNKDISVRLSYESSVTLDPLYSLSRLGVLWKNMEKDAKEKYFSLARQVDAEHKRKYPGKSFFFFIINGSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MWX8</accession>
    <name>A0A8J2MWX8_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS10932</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5102272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MWX8"/>
    <dbReference type="OrthoDB" id="88467at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="448"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="137"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="137"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5102272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="499" mass="55888" checksum="D342DFF7F0833555" modified="2022-05-25" version="1">MRRAGNGLKLDLTEHTPGSSSSRLPNLVEHAESSTCQGITGIAGENLNSKLPNVVEGSMDYGNERRSSRYLDYDPKCFQESQTAGGYIDSGGGAATTNDVSYGDRSYLARSYDRNLSDAGYDRDNVDRYNSRLYPDESVRYDRTADRSYQESDLDAPYEKKDNQKLRIYNQDSHDIGRRYSRDLGNYEYSTRYAEETLKLEPKKDHCHLTDKIYEPVNKVYGSIGKSGYESGVKTRESSYELGTCSNSEIVGRLKYESKYDSSAKVYGTLPRYESSGKSYDGYDTAGRSYESKYDDGTYDSGTKGFQSSTSKYELSTCKSYIHERSKYEPVARYQDTSVKSYDQTLKISELGTSSNVYQRKQNSESTAAVTSTSEKINGYKKNNFEAYGVYSDPEDDHGFISEKKTTPYTYKGVVVNATGESSVVDQKKAKDPQQTTVTSSPWCRPTILLLLLVLLIVIFVLIAGILLKSQEVTSMSVARVGDTLVGRNCLPCSFMCRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MY32</accession>
    <name>A0A8J2MY32_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zinc finger protein 830</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Coiled-coil domain-containing protein 16</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">HICCMSTLAB_LOCUS12370</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus speckle</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5106659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MY32"/>
    <dbReference type="OrthoDB" id="77607at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044773">
        <property type="term" value="P:mitotic DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033314">
        <property type="term" value="P:mitotic DNA replication checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033260">
        <property type="term" value="P:nuclear DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059039">
        <property type="entry name" value="ZNF380_CC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040050">
        <property type="entry name" value="ZNF830-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13278">
        <property type="entry name" value="ZINC FINGER PROTEIN 830"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13278:SF0">
        <property type="entry name" value="ZINC FINGER PROTEIN 830"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23406">
        <property type="entry name" value="ZNF380_CC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="13" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="6" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0498">Mitosis</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <keyword evidence="8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="ZNF380 coiled-coil" evidence="16">
        <location>
            <begin position="194"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="274"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="8"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="274"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00030672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF23406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CAG5106659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="309" mass="34761" checksum="92758BDD76DFFF22" modified="2022-05-25" version="1">MSNAKKLTQHELRKAMSDHKKKTGAVKKIESPLAKYPFKSNNLIIILLVLHYNDLGQLMCVICKSVVRSETVWPVHLNSKSHKDNVAAAKKSLEVKATVNKAPTSAFKRPPSPTRTEVPIKKVKGILKNSGNVNIPSVLPADFFDAPAGREDTSPAVKNSEKVIVNINNNKSIESTPVKAEQVQETESTNSAPLPEGFFDDPILDAKVRNVEYKNPVEEEWDRYLKEIKEETTQSAQIIAEDHELATSERQNNEIDEQMGNLLRVVALDEWKEENTVPKNTVEKNNESSSDDDSDVDEFLDWRVKKSYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MYQ1</accession>
    <name>A0A8J2MYQ1_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS11846</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5104126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MYQ1"/>
    <dbReference type="OrthoDB" id="189220at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5104126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="140" mass="15501" checksum="D06323B2708C187B" modified="2022-05-25" version="1">MGDVSEGEDGKKISEIGLEDLIFYPGGLKRCGGGMSSPALGGTDDATVARVVGMVGNLAGAVAGLPRTHSMSALRSRPPRRAVFWEQQCFASPTKRDYSIDFVLKKLFKLMQKFMLQYTESWRRSYRYPVCPDTCLVTIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-10-16" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>S6D4R7</accession>
    <name>S6D4R7_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cc_serrich.3_29.15</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">ser-rich3</name>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS6133</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Philos. Trans. R. Soc. Lond., B, Biol. Sci." volume="368" first="20130047" last="20130047">
            <title>Functional endogenous viral elements in the genome of the parasitoid wasp Cotesia congregata: insights into the evolutionary dynamics of bracoviruses.</title>
            <authorList>
                <person name="Bezier A."/>
                <person name="Louis F."/>
                <person name="Jancek S."/>
                <person name="Periquet G."/>
                <person name="Theze J."/>
                <person name="Gyapay G."/>
                <person name="Musset K."/>
                <person name="Lesobre J."/>
                <person name="Lenoble P."/>
                <person name="Dupuy C."/>
                <person name="Gundersen-Rindal D."/>
                <person name="Herniou E.A.Drezen.J.M."/>
            </authorList>
            <dbReference type="PubMed" id="23938757"/>
            <dbReference type="DOI" id="10.1098/rstb.2013.0047"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5092426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="HF586473">
        <property type="protein sequence ID" value="CCQ71184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S6D4R7"/>
    <dbReference type="OrthoDB" id="7695943at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="81"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5092426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCQ71184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="150" mass="16599" checksum="F3D696272982CE63" modified="2013-10-16" version="1">MADRKASSSRPEKSKEAPGNAVTRFIRRLSPIKRYRGEEAPGASSSSSSQKTDTRSGKKDSSPTKNSSHKEDKHSEKLTKSFLNLPESSSSSKSSLSQPSSLWLTPAPSYQSLNTNERATKLKLLSQLHANFDEATNILENYISLRDQKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2E5V3</accession>
    <name>A0A8J2E5V3_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS989</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001114">
        <property type="protein sequence ID" value="CAG5074262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2E5V3"/>
    <dbReference type="OrthoDB" id="7668279at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39069">
        <property type="entry name" value="ECDYSONE-INDUCIBLE GENE E1, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39069:SF8">
        <property type="entry name" value="FI17111P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035288401" evidence="1">
        <location>
            <begin position="20"/>
            <end position="549"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5074262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="549" mass="62977" checksum="53563B284E92B48E" modified="2022-05-25" version="1">MKILVIALGLLLVASILEADRYKSKHLFRQALWVEDYCERQRDCENIRNSECSRGKCKCLPNYQRSGPLRKSICRGIISAFCESDNDCLNSDEVSCIFNTCQNFTKFLDSDAEVKKLYRATALRSRCETNEHCSNLKSSICVNGKCDCYDGYGINHIGNCDPLDKRYCGELKECWTDKVTCFGDYCMLPEEFFVESNAKNISAYKAYRIGDPCQTDHHCRDLSDTHCQNGKCICVDDHYEISGRCSYYPTYKIERNYADNFLAVERSLKNCASDSDCGNKPNLHCFHGKCVCSKGFQLQDNECQEMTNSTCTRHYQCPHGIKCYLNTCRYYNEFFSSDDADKYAAEGWNSACWTDHHCRDLNNTVCFENSCKCKLGYVWDFSADKCRKWPVIKCIDDENCISNNNGEQCVFGVCKLKLELYLTPTSIDLDLYVAKNYYNFCVNDHHCRDLNNTRCHNGACECFPGHEIVSDTCQKIIGKNCTTEEECLLPGSYCFFGTCMMYQDFLALPSNITSTHAATSWYGFCQTKHHCRNLEDAICKKSECVHLER</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2EAD2</accession>
    <name>A0A8J2EAD2_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Cc_30b</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS386</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001114">
        <property type="protein sequence ID" value="CAG5073443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2EAD2"/>
    <dbReference type="OrthoDB" id="7654056at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5073443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="212" mass="25427" checksum="0961C7438E8B4EB7" modified="2022-05-25" version="1">MSSSIITHIRYDEFSLYFELKITEKYLVDIIDTINELFNIKLGFNARDNIVLQWKKKDIDHTPTYVVYNRYMDGFSYETIYCKNANHYTNENYSNMNIDNEHKQISDFCFRTNCPYFAVIIELFYMELKNLSSVYYILADFYSWATVVVANHARPRTNVQKIYQFSSYFSPLLVNNFHYLFDQSVTYIHLSFNFRNEKLQNKKSLVTIKSFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2EAV3</accession>
    <name>A0A8J2EAV3_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Similar to trh: Protein trachealess (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS1559</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001116">
        <property type="protein sequence ID" value="CAG5075405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2EAV3"/>
    <dbReference type="OrthoDB" id="6021714at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5075405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="78" mass="8752" checksum="D00625B6CE93E960" modified="2022-05-25" version="1">MLPYQVAMDYGGFQRQNSVGVGTPHQSPTSTLNINPAFTHSWFVPADLCVPYKQNQGPLLEPGHVAYLIFLFILYKLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2EAZ1</accession>
    <name>A0A8J2EAZ1_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS265</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001114">
        <property type="protein sequence ID" value="CAG5073292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2EAZ1"/>
    <dbReference type="OrthoDB" id="25654at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5073292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="140" mass="16330" checksum="92365D7E9491711F" modified="2022-05-25" version="1">MGRQVRADDVVRSTDTTEEIQVETSDISNKFKFFETYKEPEKERKQFRITPPRDGQVKMEEKATKEDVPDGPKPLKRFTPPPEDKYAKLTASDTDEEEDGEEEEEDGNEDITEEERRNPNYVRASDKVILMPLITHFYNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2EC73</accession>
    <name>A0A8J2EC73_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Similar to KDM1A: Lysine-specific histone demethylase 1A (Homo sapiens)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HICCMSTLAB_LOCUS2288</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the flavin monoamine oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001117">
        <property type="protein sequence ID" value="CAG5076817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2EC73"/>
    <dbReference type="OrthoDB" id="9982100at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140682">
        <property type="term" value="F:FAD-dependent H3K4me/H3K4me3 demethylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000064">
        <property type="entry name" value="Lysine-specific histone demethylase 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.80">
        <property type="entry name" value="ATP synthase, gamma subunit, helix hairpin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050281">
        <property type="entry name" value="Flavin_monoamine_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007526">
        <property type="entry name" value="SWIRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10742">
        <property type="entry name" value="FLAVIN MONOAMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10742:SF386">
        <property type="entry name" value="LYSINE-SPECIFIC HISTONE DEMETHYLASE 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04433">
        <property type="entry name" value="SWIRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00419">
        <property type="entry name" value="ADXRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50934">
        <property type="entry name" value="SWIRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SWIRM" evidence="5">
        <location>
            <begin position="57"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="8"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="29"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAG5076817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="348" mass="39069" checksum="ECCFC5C6CBCC128E" modified="2022-05-25" version="1">MSRRKRAKVEYREMEEKYNQVEDENASDTSDKSKTGLGTPEKKSFNEAPKVVEPVPAPAAAPVQPALKVDLTSTEAVCFPDVSAGPPQTQKVFLHIRNRLLQLWLENPKQQLVIENALPAIEAPYNSDPVLTRRIHAFLERHGFINFGVFKRLKPIPEKKIGKVVIIGAGIAGLAAAQQMQQFGIEVIVLEARDRVGGRIATFRKGSYIADLGAMVVTGLGGNPVTTLSKQFSMELHKIRQKCPLYESDGQTPVSLGQALEWVIRLQEQGVKQRQVSHLRSVLSLQGRLLANQQRMISIKERLAELNKHHREMSERKPQVHDITHEFVLRSKMRDLHYACKRSANRGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2ECA7</accession>
    <name>A0A8J2ECA7_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS1465</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001116">
        <property type="protein sequence ID" value="CAG5075311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2ECA7"/>
    <dbReference type="OrthoDB" id="7679929at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="528"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="643"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="739"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="542"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="597"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="674"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="769"/>
            <end position="779"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5075311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="779" mass="85942" checksum="5A85A431881CAD81" modified="2022-05-25" version="1">MSQLRDFYQDGDNNIIYDNIYCDIIDVSSLDFNCQETCFLDISEAKGISNLISWLKDQDTKRLIDTRTWTRAKKRYSRLSIDSIPEVAASLENSPIKPRGSHLITSTPHVPQLASSRLNFDFTERISVVPSVLRSSSSAYNGSNFGQTSLETLLNMSQQNGVDSFINMDAPELNESLLINNKQPPSLTDSLLMIEDSELVGSTHSSLSCFGAGVGIRSAGTGVKSRGVGVESDEVGEEDSAVVVGTSAEARRLESLENGPKMDDSQILTTSMMQTSLFSDTMDINNPFARDLSDGSCIENPNYSSLNNTITVNNSAPKKKIDATFNADELYAALNNESFLINRTFDNNEANHLSYVICREDTADLSVENKTYSSKKLNLQLNKCSKIVNCSEEILGVEVEEENLKIDQNLGNKECDIKINTTIQLSDDLNSTFTVDDESLPSNEFKEPLTVDNQKCLNSTFVAENNKVLNETYNNENEEDANVMKNRYQTYRKPVPSKMLLRKTFGFNMQDTRSLENLADRFGNKKSGEAKAAGVGKKSFSRLPQSLQKSNPNLNSGLKLVPSDSKPRSGLYGFRNPRTGSTEDDGLDKKSKYKFAQGSTESIESTQSIASAPDLDDCLSVDSDDKDFKERKIMENTWIADPTDLPSPILKDGEVPSGSRGSLNEGNDSHIKTSSPIISPSSSQSNDSTYGNVKPAVKPCLPPKQTVIMIVLFLKINKLFYNVAYQKSIEKLIKSPEKPEMKSGIRPPSARALSGIPRPASRIPAPGFTRSNYAKKNLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2ECR4</accession>
    <name>A0A8J2ECR4_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Similar to MCC: Colorectal mutant cancer protein (Homo sapiens)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HICCMSTLAB_LOCUS1725</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001116">
        <property type="protein sequence ID" value="CAG5075571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2ECR4"/>
    <dbReference type="OrthoDB" id="6256369at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040171">
        <property type="entry name" value="USBP1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019536">
        <property type="entry name" value="USHBP1_PDZ-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23347">
        <property type="entry name" value="COLORECTAL MUTANT CANCER PROTEIN MCC PROTEIN -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23347:SF6">
        <property type="entry name" value="FI17904P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10506">
        <property type="entry name" value="USHBP1_PDZ-bd"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Harmonin-binding protein USHBP1 PDZ-binding" evidence="3">
        <location>
            <begin position="322"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="domain" description="Harmonin-binding protein USHBP1 PDZ-binding" evidence="3">
        <location>
            <begin position="592"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="84"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="212"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="505"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="111"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10506"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG5075571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="725" mass="81106" checksum="FB754735D631AED8" modified="2022-05-25" version="1">MARIGEPLHAAALSSLRSEVAELNTRLLAATRAKEAASAALIRAEAQALRAEQRAEQQAIRHEERLTELHSVIAELSRQLERHRANVITEEDESEIETSRDAEGSITNPVEESEGGEDTQGDGDNDGDRTLGDAESSYAEEIDDPPRLNENQNQRDSRGCDSPAALPTPEPNHQEITCQSILVTSLQEEIVALKAEVANLQSQLLLFKNSGQITSSDSPRRDHKKGNLSSPEPLTAPCSPLLPPLQPPSSKNTPRDEMPILKMAERVKLRRTDERHITGPDITNLGVCSTMIAEHLVSGLLEQSNIQELNGSEEQFEVETERLKSRLEHARANNAVLALTLHESKAQCDRLSLLVGKYESNATALNLALSFSDRTIEAYDVLVALLETEMAFSTDRNSVTIDNRRTAENVAYHVLKRLESDCTTLGAPWEDSIILSDDSEVFWSIDEEQRLRKHISKLKNDRAMVRSTAVELETVHVEPLNSKNTISLAEARKLDLETAVLMQELMAMREDKAELRARVFLLEKERSTIELKLNSREAQIAAQNTAIQHLQDQLGDTEAMLAVATDKDRKYNDSESEGMESELIEALGREARLKERLHELVNTLENVTRNSELRHQQSADLINDLKVANEALVQSLEKSKKKYQSRLKKLEQQMLIMVERNAAQIKLRNEICSILVYNDLCSILVYNDLVKILKQRISMLEEEAASFKGSLPLQSQSSGAKYSFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2EDH4</accession>
    <name>A0A8J2EDH4_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS1515</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001116">
        <property type="protein sequence ID" value="CAG5075361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2EDH4"/>
    <dbReference type="OrthoDB" id="10504965at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="120"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5075361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="268" mass="31274" checksum="8FC514F3E9A388B1" modified="2022-05-25" version="1" fragment="single">VNVSDDEETNDEEDVIGDFHSDRKVIGAEKTNNRESSRAEMIKKLPNSVNPTKFNVKPGTSKSGNIDVPENGQEKIKVTSDKHVQLDDHLAQLHQQRKLEEKRLKEEEQAILERRELERQRHRTRVQQQRRLLETQKQQRRNRNDNDIYLQNDQFLLGDDFYISSAAYRDANTADTPSRFIIRMAHAIWPTAELAQRVIRKQSNTGDRKSLTPRKVELLSYRFEEFLVDRNYSEERTGFELAKMNKYLGESITSAKKKLGFSKGKQSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2EDN4</accession>
    <name>A0A8J2EDN4_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to Nit1: Deaminated glutathione amidase (Mus musculus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS2142</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001117">
        <property type="protein sequence ID" value="CAG5076321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2EDN4"/>
    <dbReference type="OrthoDB" id="680339at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047710">
        <property type="term" value="F:bis(5'-adenosyl)-triphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016811">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07572">
        <property type="entry name" value="nit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.110.10:FF:000005">
        <property type="entry name" value="nitrilase homolog 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045254">
        <property type="entry name" value="Nit1/2_C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001110">
        <property type="entry name" value="UPF0012_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23088:SF27">
        <property type="entry name" value="DEAMINATED GLUTATHIONE AMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23088">
        <property type="entry name" value="NITRILASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01227">
        <property type="entry name" value="UPF0012"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CN hydrolase" evidence="2">
        <location>
            <begin position="29"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5076321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="308" mass="34591" checksum="14CBD7964BD25442" modified="2022-05-25" version="1">MSRVSSTLLLSNNLFNKIRTHRLMSTSMNPLVAVCQMTSTENKEKNYSIVEDLVIQAKQRQACMAFFPEACDYLADNRKDIVAMSESQDGPIMSKYMQLAKQQDIWLSLGGLHEKRSDSSENKISNTHVVINNKGAIVAFYRKIHLFDMENKEIGVRLMESDYVVAGDKIVNPVDSPAGKLGLSICYDMRFPELSLALRNSGAEILTYPSAFTYQTGAGHWEVLLRSRAIENQCYVIAAAQTGAHNKKRVSWGHAMILDPWGTIIAQCSEKTGIAIGEIDLKLLNKIRDNMPCNKHRRTDLYPSININ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2EEZ1</accession>
    <name>A0A8J2EEZ1_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Mutator-like transposase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS175</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030000969">
        <property type="protein sequence ID" value="CAG5072747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2EEZ1"/>
    <dbReference type="OrthoDB" id="7698403at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049012">
        <property type="entry name" value="Mutator_transp_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20700">
        <property type="entry name" value="Mutator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mutator-like transposase" evidence="2">
        <location>
            <begin position="28"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5072747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="174" mass="19275" checksum="55A18139E94F1C56" modified="2022-05-25" version="1">MKIVNSLREKKATKNDNKPAESNLIEGPRLVDLKELGKNLRCCKCDEVLCLDNVSDETRVAFHSTLKVNCPKCNVVTLVSTGKCHRVNNNNRTKRSDITTGVVLGAVHAGYGCSGLNKILACVNMPLISSKIFKRYEREVGPAIEKAAQESCKRAASEERQLVLNNIEKLCEFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2EF46</accession>
    <name>A0A8J2EF46_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Similar to wun: Putative phosphatidate phosphatase (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HICCMSTLAB_LOCUS268</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PA-phosphatase related phosphoesterase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001114">
        <property type="protein sequence ID" value="CAG5073298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2EF46"/>
    <dbReference type="OrthoDB" id="8907274at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008195">
        <property type="term" value="F:phosphatidate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046839">
        <property type="term" value="P:phospholipid dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006644">
        <property type="term" value="P:phospholipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.144.10">
        <property type="entry name" value="Phosphatidic acid phosphatase type 2/haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043216">
        <property type="entry name" value="PAP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000326">
        <property type="entry name" value="PAP2/HPO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="PAP2/HPO_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10165">
        <property type="entry name" value="LIPID PHOSPHATE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10165:SF103">
        <property type="entry name" value="PHOSPHOLIPID PHOSPHATASE HOMOLOG 1.2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01569">
        <property type="entry name" value="PAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00014">
        <property type="entry name" value="acidPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="Acid phosphatase/Vanadium-dependent haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="53"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="102"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="178"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="239"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphatidic acid phosphatase type 2/haloperoxidase" evidence="7">
        <location>
            <begin position="107"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG5073298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="303" mass="35068" checksum="9335C29AF1FFD91A" modified="2022-05-25" version="1">MTNIWKSNGTKIIVDIFCALMLIAAVVIVNFFMEPHRRGFFCGDQTLMYPYVAHTVFSISKVVILGFEFLFLIILAEIFLGRKNKRQQIKLFNCKIPNWVSFSYYTGGYYVIGTLTTLLIGDIMKYFTGRLRPNFMELCKPSINCSLPIYQNKYITPEQFECTSAYGDSGSKEARLSFLSNHASCIAFFGVLLIFYLQSRITSSVLRIPKHLFQAALVSMISFISMTRLSYYRHHWSDVAAGILIGSVNALITVFLMADLFKKDEPEGEHDYQLEHEQQYDIDNYIEDRNNNTINVYHKWMLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2EHZ5</accession>
    <name>A0A8J2EHZ5_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS410</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001114">
        <property type="protein sequence ID" value="CAG5073467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2EHZ5"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5073467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="68" mass="7870" checksum="29A7897704A07CB1" modified="2022-05-25" version="1">MNACDSKVAQHVRQLVDGKFEVDLEYAIKDILRGPPIKELCIYFEKVLDRIKFGTSEAEPKNEEEESR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2EII5</accession>
    <name>A0A8J2EII5_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS713</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001114">
        <property type="protein sequence ID" value="CAG5073941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2EII5"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5073941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="73" mass="8067" checksum="58C9D6132C0409D4" modified="2022-05-25" version="1">MEMQAELPFTLTRPTPSEELSVPRSLPSTSAVQCPSSTPDNKPGPSDVNLINLSSDDEEERILEDLAREQLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2EIS4</accession>
    <name>A0A8J2EIS4_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS688</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001114">
        <property type="protein sequence ID" value="CAG5073916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2EIS4"/>
    <dbReference type="OrthoDB" id="7680538at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5073916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="138" mass="15711" checksum="E1566564EC5A606A" modified="2022-05-25" version="1">MVIKLIYIGKVRELLQADPSSVDVGKLSPYRVRKHGRSMSVQSSLDPYGSNTTLSSCGSDQEQEQDSGVKIEPQINLINDSIQDNYQDLMTSTMILTRQENFIEDDGNLDRTTGLYIRLVIKQDGRPDLVWLYKTHKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2EKR2</accession>
    <name>A0A8J2EKR2_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Mediator of RNA polymerase II transcription subunit 31</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HICCMSTLAB_LOCUS2136</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the Mediator complex subunit 31 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001117">
        <property type="protein sequence ID" value="CAG5076309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2EKR2"/>
    <dbReference type="OrthoDB" id="10257739at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1340">
        <property type="entry name" value="Mediator of RNA polymerase II, submodule Med31 (Soh1)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038089">
        <property type="entry name" value="Med31_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008831">
        <property type="entry name" value="Mediator_Med31"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13186">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05669">
        <property type="entry name" value="Med31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0010">Activator</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 7" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="97"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="97"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU364129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAG5076309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="116" mass="13909" checksum="B4FBE17B1A0E5161" modified="2022-05-25" version="1">MNRLDDPSNFIKGRKPTFIGMNGGPETDDQQRARFQEPEYAKYLKYPMCLYFLDLLQYEHFRREVVNSQCTKFIDDQQILLWQHYTRRRTRLLQTASEQTQQHVTQNNGIVQPKVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2EKT3</accession>
    <name>A0A8J2EKT3_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidase M13 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS1958</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001116">
        <property type="protein sequence ID" value="CAG5075977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2EKT3"/>
    <dbReference type="OrthoDB" id="7613900at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000718">
        <property type="entry name" value="Peptidase_M13"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51885">
        <property type="entry name" value="NEPRILYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="13"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5075977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="101" mass="11748" checksum="C85381178A7F71AE" modified="2022-05-25" version="1">MLRKGFQYQGVKYFVSVVFSFALVIPCVLMSSIRKNDVKLRNENVNPCDNFYQYVCGNYNDSITPEEKFKSHTVEAGKLVEELIQETAARNNEFRPFKLIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2EKZ7</accession>
    <name>A0A8J2EKZ7_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">adenylyl-sulfate kinase</fullName>
            <ecNumber evidence="2">2.7.1.25</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HICCMSTLAB_LOCUS2079</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="pathway">
        <text evidence="1">Sulfur metabolism.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.25" evidence="2"/>
    <dbReference type="EMBL" id="CAJNRD030001116">
        <property type="protein sequence ID" value="CAG5076098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2EKZ7"/>
    <dbReference type="OrthoDB" id="506431at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004020">
        <property type="term" value="F:adenylylsulfate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004781">
        <property type="term" value="F:sulfate adenylyltransferase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050428">
        <property type="term" value="P:3'-phosphoadenosine 5'-phosphosulfate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000103">
        <property type="term" value="P:sulfate assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02027">
        <property type="entry name" value="APSK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.400.10:FF:000002">
        <property type="entry name" value="ATP sulfurylase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.400.10">
        <property type="entry name" value="Sulfate adenylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00065">
        <property type="entry name" value="Adenylyl_sulf_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002891">
        <property type="entry name" value="APS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059117">
        <property type="entry name" value="APS_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025980">
        <property type="entry name" value="ATP-Sase_PUA-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024951">
        <property type="entry name" value="Sulfurylase_cat_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00455">
        <property type="entry name" value="apsK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003013">
        <property type="entry name" value="PRK03846.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11055">
        <property type="entry name" value="BIFUNCTIONAL 3'-PHOSPHOADENOSINE 5'-PHOSPHOSULFATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11055:SF1">
        <property type="entry name" value="PAPS SYNTHETASE, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01583">
        <property type="entry name" value="APS_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01747">
        <property type="entry name" value="ATP-sulfurylase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14306">
        <property type="entry name" value="PUA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="APS kinase" evidence="7">
        <location>
            <begin position="41"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-sulfurylase PUA-like" evidence="9">
        <location>
            <begin position="222"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="domain" description="Sulphate adenylyltransferase catalytic" evidence="8">
        <location>
            <begin position="388"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="domain" description="Sulphate adenylyltransferase catalytic" evidence="8">
        <location>
            <begin position="478"/>
            <end position="575"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF14306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAG5076098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="584" mass="65949" checksum="D9B0A073502A49EA" modified="2022-05-25" version="1">MTTDPGPSKRMMTTCTNVSVQAHHVSRAKRGQKLGTVLGFRGCTVWLTGLSGAGKTSIAFQVEAILVERGLAAYGLDGDNVRTGLNCNLGFSPEDRKENIRRVAEVSKLFADSGQICLCSFVSPFEADRQMARRIHKDFDIPFFEVFVDTPLNICEARDTKGLYKKARLGTIKGFTGIDQEYERPSKPELVVTTVGCSVEESAAKIIDLLEREFIIPRQKEQVVQELFVPLERVHKAKQEAKSLVDVEIGQVDLQWLQVLAEGWASPLTGFMREDQYLQTQHFRFLVDPNLDQEVNQSIPIVLAITDQDKLKIEGHSAVALKFQGQAVAILRKPEVWSHRKEERCARQFGTTDPRHPYVKLILEGGNWLLGGNIEVLERIRWNDGLDEYRLTPNEIRARLREMNADAVFAFQLRNPIHNGHAMLMQDTRKKLLDRGFKNPILLLHPLGGWTKDDDVPLATRILQHKAVLEDKVLEEEDPAGIPHPDKNATPDGNLYDPTHGARVLTMARGLGNLEIIPFKVAAYDVKNKKMAFFELERKEDFDFISGTRMRGLARTGQNPPDGFMAPKAWQVLVNYYRNGERDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2EP46</accession>
    <name>A0A8J2EP46_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS2209</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001117">
        <property type="protein sequence ID" value="CAG5076520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2EP46"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5076520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="105" mass="11225" checksum="9A3D330128AC759A" modified="2022-05-25" version="1">MSDRESLDDQPQKYGNSGMDAGGADFDAVSRQNRMKMYVIRLDRRLVDLLSRGGVGASAMQSSVVALRAFFSKPLFGDAVVIEAGHGAAKSRSTGSMHSTIISLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H005</accession>
    <name>A0A8J2H005_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similar to SPOPL: Speckle-type POZ protein-like (Homo sapiens)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS1352</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001116">
        <property type="protein sequence ID" value="CAG5075198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H005"/>
    <dbReference type="OrthoDB" id="7624723at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24413">
        <property type="entry name" value="SPECKLE-TYPE POZ PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="159"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="456"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="669"/>
            <end position="736"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5075198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="813" mass="95376" checksum="3807FF054B7896AC" modified="2022-05-25" version="1">MNLVTHEGANEYKFDYVLKLETNGKWLQSPAFNIIDIPGTEFNISAQIAEDYKDINVQIQKSNLKPAMAIIKVQVKKMKPMIYSVVDWRKNIDFHNFSFSLDPNLCRKYILFPLHSNMIKSYYEVRIYCSIIWQGYLEDAYHLDVCNHMKNYYDNTDFSDMKISVGGSEFPVHKNILAKQSPVFYKLLTSDMKESKENVISFPDDDVSSVKEMLLFFYEKKLDEATRNEEMALKLFKFAAMYQIDRLKTACEYILVKNLKIIFMLWERIVIQLFCNNMQLFFSRIMSLICLTQPSKMRLMTKEGKNIYTFTHKFKLPIYCASMNSSLTLDIEDIPDCEFKISAKIADDYMNIYVQVQKSDLRPAVAIIKIQMENHKSKIIRVIDWRKNVDFNNFILSWAFNTCNKNQKKPAECLASHHTFEMTISCSIIWHGYVEDLYHPDVCQHIGNYWDNTVFSNVKIKVGDSEFPAHKIILAEQSLVFNEMLISDLKGSREDIIFFPDADVDVIKEMIRFFYQNRLDKAINDEKMMLKLLKFAIRYQIDKLKAACEYILIRDLKIDNVFNLHAVGIDYNLSILQQHAIAFLENNSSKPLIHPVVDWTQNVDFNHILICVTPDWQKDISYKCEFSYSRLYRSIPVHCSITWQGYIEDTYYLDMCTHIKNYYKNTEFSNMKIKVGDCEFPAHKNLLAKHSPVFHKILISDMKESIENIISFPDADVSTVKEMLLFFYEKKLDEATKNEEMTLKLLKFAAMYEISRLKTACEYILIKSLRIDNIFILYAVGKYYNSTILQQHALIFLKNNASDLLEGACEMFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H279</accession>
    <name>A0A8J2H279_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Corticotropin-releasing factor-binding protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Corticotropin-releasing hormone-binding protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HICCMSTLAB_LOCUS1147</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Binds CRF and inactivates it. May prevent inappropriate pituitary-adrenal stimulation in pregnancy.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CRF-binding protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001116">
        <property type="protein sequence ID" value="CAG5074936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H279"/>
    <dbReference type="OrthoDB" id="10056927at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051424">
        <property type="term" value="F:corticotropin-releasing hormone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009755">
        <property type="term" value="P:hormone-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051460">
        <property type="term" value="P:negative regulation of corticotropin secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.290">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008435">
        <property type="entry name" value="CRF-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056178">
        <property type="entry name" value="CRF-BP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056177">
        <property type="entry name" value="CRF-BP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035914">
        <property type="entry name" value="Sperma_CUB_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10278">
        <property type="entry name" value="CORTICOTROPIN-RELEASING FACTOR-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10278:SF0">
        <property type="entry name" value="CORTICOTROPIN-RELEASING FACTOR-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23541">
        <property type="entry name" value="CRF-BP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05428">
        <property type="entry name" value="CRF-BP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49854">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035278128" description="Corticotropin-releasing factor-binding protein" evidence="10">
        <location>
            <begin position="22"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="domain" description="Corticotropin-releasing factor binding protein N-terminal" evidence="11">
        <location>
            <begin position="60"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="Corticotropin-releasing factor binding protein C-terminal" evidence="12">
        <location>
            <begin position="189"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00033162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF05428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF23541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAG5074936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="327" mass="36565" checksum="E176A1120B32CC4D" modified="2022-05-25" version="1">MPRREVFILIFVFFTITLSYASIILHERHAPAGKMAPDSITNYIFKGIGKIVPPSIIISDCVFVTSEPGKFIYESQSDEPTVCGVYLITDPDKRIEVNFLSFDVPCEQDGLVSFVDGWELNGEFFPPENDHELPFEKRVTEFCGPRVSHTFLSSQNSALVQYRVPFKGKGFTMFVRYRKNPFPCNILVNSTMDTFTLRNFGERKNCTLATIYPSAVQIVALNVGTKKLKGPSYLRQLDAGIIHHCDKHRLMDQVLIGGSNGLDTSKFELLDSVCGFTSKPERSFKLIGCGVTAIRLTSSGIFDNSVSVFVRPAIDEEIMNSNLICGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2025-04-02" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H2B1</accession>
    <name>A0A8J2H2B1_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS1265</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001116">
        <property type="protein sequence ID" value="CAG5075102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6368736at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="430"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="788"/>
            <end position="937"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="959"/>
            <end position="1019"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1467"/>
            <end position="1495"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1508"/>
            <end position="1539"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="45"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="430"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="461"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="471"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="525"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="551"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="564"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="598"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="638"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="652"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="725"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="810"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="851"/>
            <end position="868"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="909"/>
            <end position="919"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="967"/>
            <end position="977"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1481"/>
            <end position="1492"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5075102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="1777" mass="197997" checksum="D065A125EA427505" modified="2022-05-25" version="1">MRFGKKWPSFSRYLENTKESGKNNVFLKVMKNNNINRMDCELETKVLVEKKRRELIEKYKILKENLHRAKECTKEKEKLLESERSANKAFRLKMNSEKQAINTVTKEKSQLIKQIEELDTKLQAQTKYNEQLSSKIEELENENKEKLMDKDLKLSGLRIDNQELKKKLQAYQKKDPKLAKKMEQLEKQKKLKKSQPFNSTRNTGLVDLSALDNVSEEPGSSPEHEVDIPLEQEFDIPLEDISTRDQGTDTCDLSFELVPTPRKRGSKKIMRNMECQVGPKLQDRSTMTKSLSRSQELYPLYCKECHKSLGPKPIDEILNTMTSLSPKLDAIGPPEAPRKSLPAILPSTSTYNDDATQNAVEIARFASRQDGGQVSQNGGEKIEKRLGKIEKQLKGLQKGQAPCCGHNTGGGDLQVNLLTTLLEKVLRKSPVKRKRKELKGRVAKKKVKKNSRGQVHEKSSRSRKKKRSRTSRSSSRSSSDSLSSENSSSSESSRISSSSRSSSMSRSLSRSSRRSCSRDRKRSEGSSSRNLSRVGSRNRNSLSPSPKNNRRSLDSRFRNRERSVSSNFKNPRSSSRNCNGPSPSSKNNKRSRSRNREPSIGSNSRNPSRSSSRNRISLSSKNNKRSDSSSSQNRNRSRNRERSKSLSKEPTPRSSSKHSIQSRVRKPRRRLISDDELEPFQEPTNSESDISAPKFKNPVSAVKNRPDPGMFSPDLISKTLTNTLEPKEVPEPKRKGTKGPKTTAQVQTQLLKKLRKLKTNKPATTPCSSSLTPTEVCEVTKRKRIAHVPKEPGEVTLPVKKRKTRSMAAKKSDCSGETPKDVMEPENGTENEESKVPESSPAKAVLMEEVPAVKKRENLIDETPDHEQSVNSPEVMDSLNTESPASPDPEGSIDANLANILSETSADPKNLELEPKESNVENILESPESPDPTSDELILDTATSSESPEISLGIDIAMNTETSEEDTAIRSESKDMVVESSSEASDIEMDVETTLEPATPEPEPEVPEKISDTSENATIPVPKFLERGKLVTAPRMLPKTIEKPCKSNKPIALGRKSSNAKMPEVIVTKPDSEVLESQNNSMNTRTLRSRTVSISPSRVLPKIRRISPTKNLPEVPLISPGTLENDSKPLESRIFVPGTNVPGTTTPVTNVPGTLDPDCSVPGTATLKNSVPETPVPRTFVPGTSTLEKSVPGIPVPGTPVPGTLVPGTVTLENSVPGTSVPRTMEPPLTTEIFLKNSNTHPENSNIPNEPQRQRSIQNLLDFYLLTRTTPVIIQNSVLHRNVAIMMSDSATKSIKTEFQRFLDSEWTCELTNSLIANLRNLEPVSIASALVEVLKERSEPLSYEHTPPAPPMTVSQQKLIGFLAKFEMERPGTTEHVMVIIAQLLFKVKASKDDDEIDVETLQALSRFFILVTKIKKDRERARIFLCDALYALQKKAFYVLHIFMTCWAEVIPRYDESTMSFLPTGGNLTQNGGQGTQNGGSEQDGGQESQTPSFYSEISETLSLKTFGSQNGGQGSQNGGRRQDGGPGTQNGDFTCCQNGGQVTQNGGVSQNDVIETRKKYLVISITTAIKNHRDNSKNDNISQKIINVKRLLKTLYNYPDEFISIKVVENLLEAMKVKRDNSCLIAAIVLLAKREGSNWTSQHVVPKLVKMVTTGGASNNAYDILTLLGYILRPFPLNDETKQVENVINLLCQILDAKTEPVEFQEGAAMALMSLARTNFVKTAPTLLRWRPSRPITGELKTRLQHWFESRTPQYWNQFLKNNDLKVGKGSKLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H2E1</accession>
    <name>A0A8J2H2E1_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to spop: Speckle-type POZ protein (Danio rerio)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS1354</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001116">
        <property type="protein sequence ID" value="CAG5075200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H2E1"/>
    <dbReference type="OrthoDB" id="684045at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030163">
        <property type="term" value="P:protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd14733">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.710.10:FF:000159">
        <property type="entry name" value="Speckle-type POZ protein B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.210.10">
        <property type="entry name" value="Apoptosis, Tumor Necrosis Factor Receptor Associated Protein 2, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002083">
        <property type="entry name" value="MATH/TRAF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008974">
        <property type="entry name" value="TRAF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24413">
        <property type="entry name" value="SPECKLE-TYPE POZ PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22486">
        <property type="entry name" value="MATH_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49599">
        <property type="entry name" value="TRAF domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50144">
        <property type="entry name" value="MATH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MATH" evidence="2">
        <location>
            <begin position="13"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="177"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="MATH" evidence="2">
        <location>
            <begin position="325"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="510"/>
            <end position="577"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5075200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="673" mass="77485" checksum="C4A58C4DEA1DF48D" modified="2022-05-25" version="1">MIKTGCSYSVKHSIVYEWKINEITSFLNAAKHSEDVEEMNSPKFSTGAKIKDSWNLQLRVAKDSDSSNKKSWMSLYVKSNIDTKIRASFAFSMVNNKKERAYIDIDTNLVIGIDLKAVQSSRFFNHLGKYWGFKNVITIDKLLEKKQEFLPNDVLTVCVDLTVYDDYLEIKNQIAPLRVGDKKFDAHKFILTTRSCVFEAMFSYDMKEKKENEITIIDIDGEVFEKLLEYIYTDKVEDLNIFAEGLLEASDKYQLQGLKEICEDSLARNISIENAIRVLILADRHSAKQLKEVVDNYVVSNFVKFKNTEDFKALKEGYSFSVEHSIVYEWKTNGITSFLDAAKYSEELEMMNSPKFSTGAKMNDSWYLQLSIKKDSNSLNSKSCMSLYLKSKIDMKVRVMFAVFILNNKKERMYMTIDNNLVIDVDSKANQFGRFFQYSADNWGFSNVIEINELLAKKEEFLPNDILTVCVDLTVYDDYLDVNNSINSMKITAEKLSEDFEKLLIFKKNSDVVILVGDKKFDAHKLILTTRSCVFEAMFSYDMKEKKENEVTITDIDCEVFEKLLEYIYTDKVENLDIFAEGLLDASDKYQLRGLKEICEDSLAKTISIENAIRILILADRHNATRLKEFAMNYAVINLANLKNTGDYEALGKFQPSLALALLQKYVDGIKTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H2Y3</accession>
    <name>A0A8J2H2Y3_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS180</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030000978">
        <property type="protein sequence ID" value="CAG5072752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H2Y3"/>
    <dbReference type="OrthoDB" id="8060926at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5072752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="245" mass="28501" checksum="05B2A7D2A9F3768F" modified="2022-05-25" version="1">MEQINNLTNSKSTNPQIESEELLDLLERYEIYRNQTLEERHDHDKLYNITSGKNAAPEIEEFLLNVEKIGDDARKTFITECIEYPERYSLPIKRQKVQTFVNTVKKKKVAVSGRVQEKTLQNLYIVDGLLFINSLKEIPRTFGDLSKKILSSLCKISATGIDVIFDRQFIPSINDTNKCISGRSEREFKILGSNQVRPSDFAKEMKNSKFKEALISFFLKHWQESDYNILGDKIININFDVLRWP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H3J5</accession>
    <name>A0A8J2H3J5_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PAX-interacting protein 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">PAX transactivation activation domain-interacting protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HICCMSTLAB_LOCUS1239</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001116">
        <property type="protein sequence ID" value="CAG5075062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="342264at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044666">
        <property type="term" value="C:MLL3/4 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17714">
        <property type="entry name" value="BRCT_PAXIP1_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17710">
        <property type="entry name" value="BRCT_PAXIP1_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17711">
        <property type="entry name" value="BRCT_PAXIP1_rpt3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18440">
        <property type="entry name" value="BRCT_PAXIP1_rpt6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051579">
        <property type="entry name" value="DDR_Transcriptional_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23196">
        <property type="entry name" value="PAX TRANSCRIPTION ACTIVATION DOMAIN INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23196:SF1">
        <property type="entry name" value="PAX-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00533">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16589">
        <property type="entry name" value="BRCT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12738">
        <property type="entry name" value="PTCB-BRCT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16770">
        <property type="entry name" value="RTT107_BRCT_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00292">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BRCT" evidence="8">
        <location>
            <begin position="13"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="8">
        <location>
            <begin position="101"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="8">
        <location>
            <begin position="975"/>
            <end position="1056"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="8">
        <location>
            <begin position="1241"/>
            <end position="1304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="245"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="327"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="462"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="823"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="249"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00030146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAG5075062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="1420" mass="162025" checksum="222EAD2EF6C9E23D" modified="2022-05-25" version="1">MGDIRAGLEELKLDVALFADVKFYITGRADPKVLSLLHKGSAERSNYFSDFVTHLIAGEEPAESELFEAKDIYEIPAVTQDWVLQSAKCKQLLPTHYFSAQENQLFSSIRISTTCLSSRDIESIWAMVTLQGGHFLPRLDRTITHLVAGKASGSKYEAANSRGIKIVTPDWVTECCRTRSLVDESEYHPRLMVYPAPSSISLITGFIDQDQEDPEDKTLDDVLKTRLPWENYGMPVQVQQVLQQVQVQPTSPESPQYQRPVSTSSLTYNSQNWTPMKPVQPVSEQSVQLQGFNQHVIVQQQQPIPVGHQQIPQNQINLQQSVNQQSVNQQPISQQSINQQPISQQQQQPVNQQQQQQQQLINQQSISQQSISQQSISQQSINQQPISQQQQPVNQQQPQQLINQQAINQQSISQQQQQQQQQQQHQQQQQSVNPQQQQQLISQQQQLIDQQQQQQSINQQPLNQQQQLMNQQQLQQQQQQQQQQQQQQQQQQQLINQQSITQPQQQQSISPQQSLNQQQQAIIQQQQSISPQQSLNQQQTIIQQTITQQQSISPQQQTMIQQSIAQQQQQQQQQQQPINQQQQMGPPQINIQHIQQQMIQQPIHQPLQQQQLTPEQRQQFLLIQQQQQQQQKIQQISQQLQQSAPQTQFIVREAPIQGQPQNQSFVVNREAWQQQQQQQQQQQQQQYHLQLQRQQLGQQRPAGWVQPQQHLRQLIHLDAQTHQKLQQMDPQQRAQVIQKIQKSRNLILQQQQQMNRQAHPAIIRTAQPVQWVQRGQIVNQKPMPVQPPALAPINSNQVIQVQAQTPPAQNFQGQLTPQQMAHLQMQKQQMARLQQIHLQQQQQQQQQQQQQQQQQQQQQQEIPLAVPAAQMPAEQLVVNAKTKTALANMLTNRLHGGAAEGSAAGQLRLMTAQHRAPPPPSQDPALLAAYQRRTLGNITNGAAAGIKMYTQQVQQPKAQFYGHNPNLKLPPDLCLLGCIFVIAEYDTQFPALEVANWKQVIERHGGEVEPDYCVRATHVLAITQKHPTVVQALRDGKRCVNAHWLSDVVSKQHVLPPWHAIHFPVPYEIGEKPLSQHNVSFSGFEGEERAKVKAMLELLQPEGPKYKKAKEWAIPCVNVQWLIDVVCGQAAHHQLEQPKYQQFNATHPFRLDYSLVPHLMTAWKMPINITQESYDKVKAVGQGPNARRNKKPRLDLTLSKDPQLLGLEEAIVVTNPDAPIPGSEMQPKILFSGTNPRKHAKRIRELGGTLAASWRDATHLVMNAPYRTVKFLCCLSRCKYVVSIQWLMECFARNTFVDEAGYGLDNEDFERSFNCNIQKALASPNRGEGKIFYVTPSVVPAPSAFAEIIESAGGTYEKTRRSLAQIQEINATKVNYIIITQANDLHLLSDVLRANIAVYSAEVVLGSVCRQSFQLETSQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H5Y1</accession>
    <name>A0A8J2H5Y1_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Similar to PRPF3: U4/U6 small nuclear ribonucleoprotein Prp3 (Homo sapiens)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HICCMSTLAB_LOCUS2475</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001117">
        <property type="protein sequence ID" value="CAG5077489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H5Y1"/>
    <dbReference type="OrthoDB" id="10264544at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd24162">
        <property type="entry name" value="Prp3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013881">
        <property type="entry name" value="Pre-mRNA_splic_Prp3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027104">
        <property type="entry name" value="Prp3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010541">
        <property type="entry name" value="Prp3_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14212">
        <property type="entry name" value="U4/U6-ASSOCIATED RNA SPLICING FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14212:SF0">
        <property type="entry name" value="U4_U6 SMALL NUCLEAR RIBONUCLEOPROTEIN PRP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08572">
        <property type="entry name" value="PRP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06544">
        <property type="entry name" value="Prp3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="3" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0687">Ribonucleoprotein</keyword>
    <feature type="domain" description="Pre-mRNA-splicing factor 3" evidence="7">
        <location>
            <begin position="197"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="domain" description="Small nuclear ribonucleoprotein Prp3 C-terminal" evidence="6">
        <location>
            <begin position="431"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="398"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="18"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="398"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF06544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG5077489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="549" mass="62995" checksum="4A7F30700C4E51E4" modified="2022-05-25" version="1">MFGIDDNDKSTKRSKKRSHEDDRDCEKDSKKVKVKEGSKNDDTAENKLSPEMIKQMMANAQKQIEERKRALNTINQNNISSVKNSFKTRDPMPIASSMYSQGLLSKADSDKARKLVVLQAQIKSKLNSGLLTSVSVPDKPTPLILDESGRTVDITGKEIQLTHVVPTLKANIRAKKREEFKAQLQDSKGPEEIQDTHFFDNRIGVKVPTRGKRALKFHEPGKFQQIAERIRVKAQLEKLQNEISQIARKTGISSATKLALIAPKTEALNEDVPNVEWWDSVILASGYPVKEDEQVQIKHSTITNLVEHPIQMRPPTESSRPVYMPVFLTKKERKKLRRQNRREAWKEEQEKIRLGLEPPPEPKLRISNLMRVLGTEAIQDPTKIEAHVRQQMAKRLKAHEDANAARRLTVDQRREKKARKLKEDTSNGVFVEANAKQLYLTGCVMLFRDCNVVVVEGGAKQLRKYRRVMMHRIKWEEDIVKDTDGNDVPNKCVIVWEGSSTQRHFGEIKFKVCPIERMAREHFKKHQVEQYWDLAYSGAVLDNTDEMNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H612</accession>
    <name>A0A8J2H612_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Similar to Fancd2: Fanconi anemia group D2 protein homolog (Rattus norvegicus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HICCMSTLAB_LOCUS2543</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the Fanconi anemia protein FANCD2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001117">
        <property type="protein sequence ID" value="CAG5077731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="27031at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000793">
        <property type="term" value="C:condensed chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070182">
        <property type="term" value="F:DNA polymerase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990918">
        <property type="term" value="P:double-strand break repair involved in meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007129">
        <property type="term" value="P:homologous chromosome pairing at meiosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036297">
        <property type="term" value="P:interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031573">
        <property type="term" value="P:mitotic intra-S DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029448">
        <property type="entry name" value="FANCD2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32086">
        <property type="entry name" value="FANCONI ANEMIA GROUP D2 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32086:SF0">
        <property type="entry name" value="FANCONI ANEMIA GROUP D2 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14631">
        <property type="entry name" value="FancD2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0832">Ubl conjugation</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1344"/>
            <end position="1389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="17"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="37"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="127"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="1362"/>
            <end position="1389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00093456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAG5077731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="1389" mass="157236" checksum="36151AEC9AB5E800" modified="2022-05-25" version="1">MDRRKIKSRGLHRNVNTRDTQSSTASTEEVNDAFASGNLSQRSQRTSNTELLRASQRSSKTSLLRQQSNLIAPSTSGTNKRRESEPNLDIIDESPDSSAKENELPDIFSSPRAKRVRVSESPSPVKKAPEKEARDPRVSRKPTGFVPRNRPQTANVLSQFFSHIGILPDESDTHYILENDPLLTVKKIQQALLSGDYSKENVLKEFDNYLSEDLGQDNKCLNPTTINSSDGRQMDSFKSSSIIKIFLQVPAIQSSVLNNSVPWAYQLLQQLRFLEVVNDPEALTLKLEELLETSPIWFQRELITFIPDIVTDTQHQMIAEILCKLMEAQRELTNVILDCISNLSLGKEFLEELRETMLTLLGRNCHIDQMAAIIKFTLDDCPSIDVCQTVLRNLRVLELQPLDGENSEEYYSNQTIIVSALRMVIVLSKEMANAAINVVASTSTNKQAKPFDLIILLLLYEGTVKKKKAEAILKQHIKTAFYRSSLLNDFYSGYQEVVKDLQSAALNMASNLLKSEDGVLIDFTTDWFRHQFLIHGELIHKQREIVEKLIVLMGNNDQTAKNALAILCKMTKNRDERRYLQAHCHYLRILLEKMEKLDLKEVTMLNDLLHALCASSSTITDTLRDDLFILLSKQLSCHDGIVKSKGVAGGVMAIKHLATSEEELKMALDIFKKILSGVKECPRSRGFFYDTLGSIIAQNDDIKVEFLNEIIKLIEDEFFNVYITDSYDGPLKPTFRLNASNDLQGLLVKFGSGKYEGIAPTLLRLMKICNQHIGNERLKISEFFNCAVLMPADLDLPDAQTIDLMFHCINWFRELINSCVTERNPLLQRLISKRLANVMQLQGELATLLSLADARYQAPPCYFHSFPLPSFNKVEKKSSKKGKKGTEDKDKDKSVAEKTLPEWESWEMGSLLSTKNPMYFRRLDAEILYLLDVTIPVQMSQSNVDNVSTGQVCFIIKELLASFNEDNVTEKFMKDLISQLSKICMKLSDFVDKLRVEESSQHNYAFRLILSLLTAIFNWKGFNNPAHHELLREGLRTLAGQVDESNLSLRSARELVSESYKYFESLADVATQISIASELVDTCKALMKHSTTFSREKKDKQAKMAYGFLCLEWPNDRQTGPLFRSSVSRLLKNWLEHEPNPLETVSSVLEWLPEEANTLEKPQDKLTRLPTIMRSNLHNLYQKLYEAFLKGTKLALQPAMTDVQKLKVWKEVALNLSRLVAICKKVSTKSMLMAYLRCTPALLKIFLESAIPTFEHCLRNHADEVTSTIKMVQGGTRYLNAICCHSTEQKDIALSKLIPNAKTILEKMVYSVKGMLVFNNTSGAFWMGNLLNKNLDGQAILSQGSVSTDERPTSVTDSSVQSDDDVLSDILDDDQDEENDNSNIGDGDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H642</accession>
    <name>A0A8J2H642_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Beta-1,4-glucuronyltransferase 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">I-beta-1,3-N-acetylglucosaminyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="19">N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">Poly-N-acetyllactosamine extension enzyme</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">HICCMSTLAB_LOCUS2602</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>3-O-[beta-D-Xyl-(1-&gt;4)-Rib-ol-P-Rib-ol-P-3-beta-D-GalNAc-(1-&gt;3)-beta-D-GlcNAc-(1-&gt;4)-(O-6-P-alpha-D-Man)]-Thr-[protein] + UDP-alpha-D-glucuronate = 3-O-[beta-D-GlcA-(1-&gt;3)-beta-D-Xyl-(1-&gt;4)-Rib-ol-P-Rib-ol-P-3-beta-D-GalNAc-(1-&gt;3)-beta-D-GlcNAc-(1-&gt;4)-(O-6-P-alpha-D-Man)]-Thr-[protein] + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46860"/>
            <dbReference type="Rhea" id="RHEA-COMP:15023"/>
            <dbReference type="Rhea" id="RHEA-COMP:17482"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58052"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:142405"/>
            <dbReference type="ChEBI" id="CHEBI:177336"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Golgi apparatus membrane</location>
            <topology evidence="2">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the glycosyltransferase 49 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001117">
        <property type="protein sequence ID" value="CAG5077961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H642"/>
    <dbReference type="OrthoDB" id="6479716at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015020">
        <property type="term" value="F:glucuronosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035269">
        <property type="term" value="P:protein O-linked glycosylation via mannose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043189">
        <property type="entry name" value="B4GAT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46420">
        <property type="entry name" value="BETA-1,4-GLUCURONYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46420:SF1">
        <property type="entry name" value="BETA-1,4-GLUCURONYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13896">
        <property type="entry name" value="Glyco_transf_49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="12" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="15" id="KW-0464">Manganese</keyword>
    <keyword evidence="13 21" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 21" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 21" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00030723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00032175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00032181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00033291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00047852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="CAG5077961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="462" mass="54060" checksum="A05F39C024710F10" modified="2022-05-25" version="1">MSNHSRTVSLLSVTALCIINITLTFFLLQSPTCDPSEIPEELKYEAVTTWDVESQPEDNKSTQCLPPHTYLNPKMNLINTSHSRENILNLDIRLGRYDNRRLFKTFDTVLIGTRFAELSTTNLVCLATQTSLEKLHSLVQVAHHWTGSISVALYSAGDEEFEALQKYIVFLRKCYTPVLERINFSLAMPRSKLPSKQPRSFEPPMDFGCSRPEATLNDLVNKISKEHTNWRVRNVYPQNHMRNLARKNCQTDWVFLTDIDIIPSIGLANSINLFLRDTERCDKCAYVIPTYEIDTRVRFPGNKTELVRLARKGLARPFHWKVFIHNQYATNFTRWVLDVAPESKNYKNIIAGKAYISHNVTDFEFLYEPFYIAKDIVPPHDERFMGYGYTRNTQVYEMFIAGYQFKVLSPVFTIHWGLQTRKSRSVWRERQNIINRRQFEQFKKEIYTKYMHNTLGLINTFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H6N6</accession>
    <name>A0A8J2H6N6_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to LRRC20: Leucine-rich repeat-containing protein 20 (Homo sapiens)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS2829</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001117">
        <property type="protein sequence ID" value="CAG5078755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H6N6"/>
    <dbReference type="OrthoDB" id="1060944at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050216">
        <property type="entry name" value="LRR_domain-containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051:SF1">
        <property type="entry name" value="RAS SUPPRESSOR PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5078755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="211" mass="23854" checksum="5A88F4831B45066E" modified="2022-05-25" version="1">MKPPHENAEGVIAQLSQEEGERNVATAICVQLAGRAIIRVVSRCEEAQDNCNLDLSECQLMQVPDAVYHLMRHTELKSCDLSGNVITKIPPKFAVKFSLITELNLSHNQFSKLPEELAELQELERLDISHNTFISLPPVTFRMPQLKRLLANNNSIIDVDVDRLKLAPSLELVDLRENTIPPKIYDQLSNCSSCKIELSPRQVEEWEDLTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H6X4</accession>
    <name>A0A8J2H6X4_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Olfactory receptor 195</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HICCMSTLAB_LOCUS2981</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001117">
        <property type="protein sequence ID" value="CAG5079315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H6X4"/>
    <dbReference type="OrthoDB" id="8185860at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005549">
        <property type="term" value="F:odorant binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004984">
        <property type="term" value="F:olfactory receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004117">
        <property type="entry name" value="7tm6_olfct_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21137">
        <property type="entry name" value="ODORANT RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21137:SF35">
        <property type="entry name" value="ODORANT RECEPTOR 19A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02949">
        <property type="entry name" value="7tm_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0552">Olfaction</keyword>
    <keyword evidence="8 11" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="9" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="41"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="71"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="127"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="265"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="296"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="360"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAG5079315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="396" mass="45075" checksum="94B68C9CA2F60A12" modified="2022-05-25" version="1" fragment="single">MSRDTWNSGTSYGLMIYKLIMWPLGLWPLNRGSVFSEIRLILAAITQASTCICLHIEIWLNCQGLEDILDIFVLSVFSLLACIKGLIVRFHQEKMYCNVSSAIEDWFTLPLNNNLENRKIMMKHARIGRIVCISLMAPASGGTLSWIIFALPLPMFIPENYTDVFRNYPLQTACTFQSITLTGFYHIVFVVQIYQLITTCLGNCGNDVFFFGLGMHVCGQLEILKNEFRRLKTTNNKIEDRKIFQNLVQRHSHLMNLIYKLESSFNLVILAQLIMSGILICIMGLQVIIALKTKNLFAGIKALVVLSSLMSQLFLYSYGGDYLTSQCEDIAFAVYESPWHKSSTKKIKDLQFIILRAEKLIYVTAGKFFCMTLGTFMDIIKLSVSYMSVLRVAVDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H6Z2</accession>
    <name>A0A8J2H6Z2_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to MLH3: DNA mismatch repair protein Mlh3 (Homo sapiens)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS3042</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA mismatch repair MutL/HexB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001117">
        <property type="protein sequence ID" value="CAG5079559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H6Z2"/>
    <dbReference type="OrthoDB" id="429932at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032300">
        <property type="term" value="C:mismatch repair complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1540.20">
        <property type="entry name" value="MutL, C-terminal domain, dimerisation subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.100">
        <property type="entry name" value="MutL, C-terminal domain, regulatory subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038973">
        <property type="entry name" value="MutL/Mlh/Pms-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014790">
        <property type="entry name" value="MutL_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042120">
        <property type="entry name" value="MutL_C_dimsub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042121">
        <property type="entry name" value="MutL_C_regsub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037198">
        <property type="entry name" value="MutL_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10073">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MLH, PMS, MUTL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10073:SF47">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MLH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08676">
        <property type="entry name" value="MutL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00853">
        <property type="entry name" value="MutL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118116">
        <property type="entry name" value="DNA mismatch repair protein MutL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MutL C-terminal dimerisation" evidence="2">
        <location>
            <begin position="356"/>
            <end position="526"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5079559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="562" mass="65490" checksum="E35C37D660AC94EE" modified="2022-05-25" version="1">MKSTYSQSQYFFKDLVRMSLDGSSTSVAIRIYNDDKKIQIIDNGHGIDFQKLEGIGVNYQKMNDNIFKHIHQLPVVVIMTKPKNSQCSYGKVLQFGHTLNVQKILDRPLHGTTVIVYFNDSTFGDFLNRQNIIEIVEDYALDYPQVSFTIRDDIGQKLNVGIKRKYCNQLQPNSIVKKLKYSPANLFNLELDSINHKNSVNEIMNVLFHKQEKNNKEMSINKNTTPFSRDNQLKIRNNYDNDITCDDISTPMSNISGEWSDWISPLERLNNNTNNDYNYNPKRRKYSFLPEKLNKVLRTAEKRLFPRQSSNQFDKKCFFNFDSGYLENVYDVRICKNKKKLSEITIDKNSLKHIKVLRQVNVEYIAGIVEQNKEKILILIDQHAMDERIRYENLLEDYKYENKFISVTLKRPIKINNVPRSNYDLLLRKREVLKKFGLNIINSSLDDERNSDNSDYFSLIITSVPKCFLFKKIYNETYVIELTAKLLMEVAEKLINKIGINTLPSTIHNVIASEACHGAIKFGDPLNINQCNDLLNYWIQTDLPNRCAHGRPVIIPLLTFNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H7L0</accession>
    <name>A0A8J2H7L0_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to SWT1: Transcriptional protein SWT1 (Homo sapiens)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS3478</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5082178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H7L0"/>
    <dbReference type="OrthoDB" id="548295at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18727">
        <property type="entry name" value="PIN_Swt1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052626">
        <property type="entry name" value="SWT1_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16161">
        <property type="entry name" value="TRANSCRIPTIONAL PROTEIN SWT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16161:SF0">
        <property type="entry name" value="TRANSCRIPTIONAL PROTEIN SWT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13638">
        <property type="entry name" value="PIN_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00670">
        <property type="entry name" value="PINc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WW" evidence="2">
        <location>
            <begin position="4"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="141"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="235"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5082178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="913" mass="103135" checksum="82EE22234DFECB7B" modified="2022-05-25" version="1">MAKVNLPKDWILVTSTTDPGRNYYFNTATNKSTWVFPDDDSDSQPTQNTRKNSTRKRKKNEEHDYRPHTPEGDPEVNRRPKLVAKRQLSTSEDPGKKKTAKQNADTPQMKALREKMLQRQAKTSAIKKPRPLKSSTLKASPSKDVDKVDKVDKAKVEKTPEKTPEKPRKNFKFDDEEEKSKDEEKVMTPAMKQMKQKMLARKSLSAVADRKKGKSSPKSQSARLSLARTDKSTSDDTVSSSTASTSTSTAQTEVQGLGSPRTRASRSLSCSTTPRRKSVKVAIESKLKQMKTLEAPPGVSAKRILIPDAEKVEDDDLQSNVSNAKIPRIGKLKAAESPEVDAKDPPVVFKNAEDRMKAFCSNLKRQRSLSSSFNDSGCSATKDSGDVFCEEMDWEPSEEEKIVSEIQNVRAQLVIEDDVQMQELNNTGLDLTDGGSGSNGSLRKLYIVVDTNVFLSNMKAVEEARDAIFKFYNRPIIVIPWTVIRELDFIKDDKSHSRPQSLKYKARHAIQFINKHFAAKHPRILGQTFADVLSNRQKFETECPDDEILQTCLQVQSAGHHVVLLSYDKNLCNKAMIHDVISLGKNDPLEKVDYLKESEIKKRFNLADSLKDVEQEETKAELLLAEELFEDLKTTLTSFMSVVVAKEMKNLYGETWERHTIIRPPWTVLTVLKCANKHWIAAVSDSFERRAESILKDLVQIVTGLQYSCQLKDVETMIQRFHDLVGCLKAVKYPNILENVTEAIEGLKQKFRDSLKLIYRNKGDNKQEEESKAALAFGYFETVYLFARDVCGTSASLMGMPFGLAFKKLESLSIEDDIKQLRPEVAGNLNRLMQILSTALDDIDHLHVDHPSVLALHQVLTGFLPELLKSDHQLMPQDVFLCLKYKQEVLKNGLGQLQDLSGYFCRMATFKCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H7P2</accession>
    <name>A0A8J2H7P2_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS3380</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5081795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H7P2"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5081795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="149" mass="16174" checksum="8E3E408EE359D157" modified="2022-05-25" version="1">MSGGMRTTCRGTRRRCASVSRASRWFYFYCSPGSAGRGCCRLAASETLLGARPDLLWNYWSCRSPGCRLVAAEACVGLLHLAGLCRALRFGLIFLIQIPVLFASSLILRLLGFLLEGCCSGRMTAGNDSTTGIFHPVGFLWGLTLTGRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H7X8</accession>
    <name>A0A8J2H7X8_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glutamine-dependent asparagine synthetase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HICCMSTLAB_LOCUS3749</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-asparagine biosynthesis; L-asparagine from L-aspartate (L-Gln route): step 1/1.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5083159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H7X8"/>
    <dbReference type="OrthoDB" id="409189at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004066">
        <property type="term" value="F:asparagine synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006529">
        <property type="term" value="P:asparagine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00712">
        <property type="entry name" value="AsnB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050795">
        <property type="entry name" value="Asn_Synthetase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033738">
        <property type="entry name" value="AsnB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11772">
        <property type="entry name" value="ASPARAGINE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11772:SF23">
        <property type="entry name" value="ASPARAGINE SYNTHETASE [GLUTAMINE-HYDROLYZING]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13537">
        <property type="entry name" value="GATase_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="5">
        <location>
            <begin position="2"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00030234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAG5083159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="166" mass="18948" checksum="1958FBA4AAFC2966" modified="2022-05-25" version="1">MCGIWAVFGVEGETLNCVCNNFNKISHRGPDALRVENDSRIKNAFLGFHRLTILDSLCGMQPMRLYKYPNVFLICNGEIYNFKQLRDKYNFSYSSKCDIEIITHLYMNGGAKNIVNNLDGVFAFCLMDMQENKVLIGRDPYGVRPLFRLLSTDGQLVVCSETKPEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H871</accession>
    <name>A0A8J2H871_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS3970</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5083930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H871"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035215912" evidence="1">
        <location>
            <begin position="20"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5083930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="145" mass="16703" checksum="BC5BCF2ED3D593F8" modified="2022-05-25" version="1">MICRIFPCILIVAISIVSADYSCPEPTRELKLSIHDPDVVRFAQDAWNEFKKYRSDCGHPLSQTEISWAAVLVVAHERRYTIVASYRFDDSVPYEFECLILVQTERSDPLLVACSKIETINNKLVYNKALTDVMTYMQRILHVDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H8C9</accession>
    <name>A0A8J2H8C9_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Similar to ACVR1: Activin receptor type-1 (Gallus gallus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">HICCMSTLAB_LOCUS4120</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5084500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H8C9"/>
    <dbReference type="OrthoDB" id="69842at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070724">
        <property type="term" value="C:BMP receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004675">
        <property type="term" value="F:transmembrane receptor protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071363">
        <property type="term" value="P:cellular response to growth factor stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23600">
        <property type="entry name" value="TFP_LU_ECD_Sax"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.60.10">
        <property type="entry name" value="CD59"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000472">
        <property type="entry name" value="Activin_recp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003605">
        <property type="entry name" value="GS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045860">
        <property type="entry name" value="Snake_toxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000333">
        <property type="entry name" value="TGFB_receptor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23255:SF72">
        <property type="entry name" value="RECEPTOR PROTEIN SERINE_THREONINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23255">
        <property type="entry name" value="TRANSFORMING GROWTH FACTOR-BETA RECEPTOR TYPE I AND II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01064">
        <property type="entry name" value="Activin_recp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08515">
        <property type="entry name" value="TGF_beta_GS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00467">
        <property type="entry name" value="GS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57302">
        <property type="entry name" value="Snake toxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51256">
        <property type="entry name" value="GS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11 15" id="KW-0675">Receptor</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5 13" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035199815" evidence="13">
        <location>
            <begin position="22"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="154"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="domain" description="GS" evidence="14">
        <location>
            <begin position="231"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CAG5084500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="372" mass="41624" checksum="A52973184786C9F4" modified="2022-05-25" version="1">MANILCIIIFMIFLGVKSSQGDIQHAPLLDDKQNGLDSEEPTEFPNQEKYVHGVQRKLTCYSCEADECIKPELCYDAAVCWKSTVREVDGTERVKRACTSMSDQVLLTCNKKPPNSKSEAVYNVECCFSDLCNKGPFPVLEPLNDNGEKYAIKLALSIMGSIIVVSIIIGGIIFFTLLSKTRRKRSLVLKRNKLLVDPELEPSMLHFPSSSLTSSTNYHPHELRATAAGDSTLKEYLDGRSLTSGSGSGLPLLVQQSFRRADIYSLGLIMWEVCRRCISNGVALDYAAPYSEWLSSNTQEPSIEEMRKLVSYDQRRPPLPNRWHSDPTLSGIGKLMRECWHGKPAARLPILRVKKTLIKLAANDSRVHLTID</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H8S0</accession>
    <name>A0A8J2H8S0_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">GPI inositol-deacylase</fullName>
            <ecNumber evidence="10">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HICCMSTLAB_LOCUS4399</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Involved in inositol deacylation of GPI-anchored proteins which plays important roles in the quality control and ER-associated degradation of GPI-anchored proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the GPI inositol-deacylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="10"/>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5087021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H8S0"/>
    <dbReference type="OrthoDB" id="348976at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050185">
        <property type="term" value="F:phosphatidylinositol deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006505">
        <property type="term" value="P:GPI anchor metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012908">
        <property type="entry name" value="PGAP1-ab_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039529">
        <property type="entry name" value="PGAP1/BST1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15495:SF7">
        <property type="entry name" value="GPI INOSITOL-DEACYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15495">
        <property type="entry name" value="NEGATIVE REGULATOR OF VESICLE FORMATION-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07819">
        <property type="entry name" value="PGAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="631"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="673"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="709"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="736"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="818"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="854"/>
            <end position="871"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="883"/>
            <end position="902"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="914"/>
            <end position="933"/>
        </location>
    </feature>
    <feature type="domain" description="GPI inositol-deacylase PGAP1-like alpha/beta" evidence="11">
        <location>
            <begin position="83"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF07819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAG5087021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="939" mass="107137" checksum="BEB9A4251196E490" modified="2022-05-25" version="1">MAKIIIYISFLLLCLISFGLYLFGVANYVTDLKPNNCDMTYMFEYPQYVRIKLDNEIENKFNKFGLYAYGEGYATEKLRRMKFTGIPVLFIPGNAGSHEQVRSLASVSLRMSLKRRTPFHFDYFTISFAKSLSALYGGILQEQTVFTEHCIKKILSLYEEYEKKLDQVILIGHSMGGIIGKSVLLQPSNQTSSPASILITLASPHTPNIAFDQTSANFYQYINSRAKRLHNSVSIVSIGGGSRDLLVTSSQILDPLADLNILSTAIPNVWRAQDHLSILWCKQLIIAIVRGLFDSVDTTQRIPKIYSQREIKLKALSYHLQNRFAGKYLTKINFQPRVNFLEEGRWIQVTGPQFSYNSNNDKPLKGKLNLNHQSIVYLMIPIPVDKFAYNFLSIDAINLDTQDWLFACTVLIINDKTSEKICKSGINLTNLTRLSPDVYFRQRKTLDLNLHEISSQVTHIVVRIPTIEADKKTLVTVHTDLYSLETRTSFIDGSGVSWLPLPLKTVLAAGDYKTVINTQSGSLRWHLDVKVPDAINFVLESVDGEDMAVYLVIEVKESWNSTKFGITEFYTLTEKDIGKSQVLRMQMDSDYLSDHIVKIIVTLDPNFTYKLRIEKAGLIDRFANFVRDRWFRLYPTALGLLLLIVATRMDDNDNNKVFVTMGFTTGLVVYSEIYFEIFIAIGLLMVLSIATCCAIIFSGSMVHNVTARFLARAFARFPAAWYGWLIRQWFDHLPFIASLILFIIISSSCAAVAMLLSVVIYFLKLTRMYEDYLEELFMATLRGFIRKIKKPSSDKQVKITKSAPRDDVNPTTNIINHLLLFMIWYLTSISAIPTTLVWAKNFSYETRLTTEDTTMYICWIVLTGWGSLGLVKISPPIPQDNKFRLRTIAMFQRIVGFILLWIAQSKNIADYQWMIPPIVAISITRIVLTPFFVKKKKSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H8T1</accession>
    <name>A0A8J2H8T1_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Similar to hfw: Protein halfway (Drosophila pseudoobscura pseudoobscura)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HICCMSTLAB_LOCUS4470</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5087276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H8T1"/>
    <dbReference type="OrthoDB" id="10068119at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050333">
        <property type="entry name" value="SLRP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45712">
        <property type="entry name" value="AGAP008170-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45712:SF22">
        <property type="entry name" value="INSULIN-LIKE GROWTH FACTOR-BINDING PROTEIN COMPLEX ACID LABILE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035196929" evidence="4">
        <location>
            <begin position="26"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="446"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="499"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAG5087276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="499" mass="57497" checksum="8D0FAC271A57600A" modified="2022-05-25" version="1" fragment="single">LINYLNMFNLFSIIFLLNIIIKVHLEKLEDKNSTVYPLSSSKCFHRESFDCPQVENLNNCPCKIIKFSADEINPKIGIYCCNLNSETLISSLECANFSVNVTDIHIRNATIKSFNVSEALWKNLESLAITDGQINNIKGQFNNDTKISCLNLSNNALSKFDNNFIAQMNYLENLDLSFNNITDLPTFSRSLTILDISGMSTIPCLEIKQAIDRDESYTRRLSFRNQNTTVCSAATDWTWFKAAERISIELLLPDISECPKGENWRCKCTFNQLIKITPGYPIFRTINVDCSNNNLTELPKKLPPYTINLVVSHNKIKKIDDIVTNPSYKYLMNFTADYNEISSINILEGSRFVENFDSFSLRFNKLKSIPTHVLIPVTYNASNEVNGNVSLGGNKILCDCYAAKYLKNWFEVNIPDGDEVNCSNSVDRVIDLNVMKMCKFDDESSDYIYCIIAIEVILLITILSKLLFDYWYYKKNRKLPWFSRIMPKTRFDWLFEFYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H9G0</accession>
    <name>A0A8J2H9G0_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Tubulin alpha chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">HICCMSTLAB_LOCUS4576</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="11 13">Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="13">Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the tubulin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5087681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H9G0"/>
    <dbReference type="OrthoDB" id="1844at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02186">
        <property type="entry name" value="alpha_tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.600:FF:000005">
        <property type="entry name" value="Tubulin alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.20:FF:000001">
        <property type="entry name" value="Tubulin alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1440:FF:000002">
        <property type="entry name" value="Tubulin alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.600">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.20">
        <property type="entry name" value="Tubulin/FtsZ, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="entry name" value="Tubulin/FtsZ, GTPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002452">
        <property type="entry name" value="Alpha_tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008280">
        <property type="entry name" value="Tub_FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000217">
        <property type="entry name" value="Tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037103">
        <property type="entry name" value="Tubulin/FtsZ-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018316">
        <property type="entry name" value="Tubulin/FtsZ_2-layer-sand-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023123">
        <property type="entry name" value="Tubulin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017975">
        <property type="entry name" value="Tubulin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11588">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03953">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01162">
        <property type="entry name" value="ALPHATUBULIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01161">
        <property type="entry name" value="TUBULIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00864">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00865">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55307">
        <property type="entry name" value="Tubulin C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="Tubulin nucleotide-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00227">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0007">Acetylation</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="9 13" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 13" id="KW-0493">Microtubule</keyword>
    <keyword evidence="6 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubulin/FtsZ GTPase" evidence="14">
        <location>
            <begin position="48"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="domain" description="Tubulin/FtsZ 2-layer sandwich" evidence="15">
        <location>
            <begin position="247"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="16">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00034296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CAG5087681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="449" mass="49819" checksum="9EFED7A28E08B1C6" modified="2022-05-25" version="1" fragment="single">RECISIHVGQAGVQIGNACWELYCLEHGIQPDGQMPSDKTIGGGDDSFNTFFSETGAGKHVPRAVFIDLEPTVVDEVRSGTYRQLFHPEQLITGKEDAANNYARGHYTIGKEIVDLVLDRIRKLADQCTGLQGFLIFHSFGGGTGSGFTSLLMERLSVDYGKKSKLEFAIYPAPQVSTAVVEPYNSILTTHTTLEHSDCAFMVDNEAIYDICRRNLDIERPTYTNLNRLIGQIVSSITASLRFDGALNVDLTEFQTNLVPYPRIHFPLVTYAPVISAEKAYHEQLSVAEITNACFEPANQMVKCDPRHGKYMACCMLYRGDVVPKDVNAAIATIKTKRTIQFVDWCPTGFKVGINYQPPTVVPGGDLAKVQRAVCMLSNTTAIAEAWARLDHKFDLMYAKRAFVHWYVGEGMEEGEFSEAREDLAALEKDYEEVGMDSAEGEGEGAEEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HBG1</accession>
    <name>A0A8J2HBG1_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Similar to PRPF40A: Pre-mRNA-processing factor 40 homolog A (Homo sapiens)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HICCMSTLAB_LOCUS6461</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5092942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HBG1"/>
    <dbReference type="OrthoDB" id="187617at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071004">
        <property type="term" value="C:U2-type prespliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.440:FF:000003">
        <property type="entry name" value="Pre-mRNA processing factor 40 homolog A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.440:FF:000037">
        <property type="entry name" value="Pre-mRNA-processing factor 40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.440:FF:000002">
        <property type="entry name" value="pre-mRNA-processing factor 40 homolog A isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.440">
        <property type="entry name" value="FF domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002713">
        <property type="entry name" value="FF_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036517">
        <property type="entry name" value="FF_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039726">
        <property type="entry name" value="Prp40-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11864">
        <property type="entry name" value="PRE-MRNA-PROCESSING PROTEIN PRP40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11864:SF0">
        <property type="entry name" value="PRP40 PRE-MRNA PROCESSING FACTOR 40 HOMOLOG A (YEAST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01846">
        <property type="entry name" value="FF"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25432">
        <property type="entry name" value="FF_PRPF40A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00397">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00441">
        <property type="entry name" value="FF"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81698">
        <property type="entry name" value="FF domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51676">
        <property type="entry name" value="FF"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01159">
        <property type="entry name" value="WW_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="WW" evidence="4">
        <location>
            <begin position="119"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="FF" evidence="5">
        <location>
            <begin position="271"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="domain" description="FF" evidence="5">
        <location>
            <begin position="402"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="domain" description="FF" evidence="5">
        <location>
            <begin position="484"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="domain" description="FF" evidence="5">
        <location>
            <begin position="620"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="165"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="204"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="678"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="324"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="452"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="178"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="211"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="242"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="683"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="748"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="780"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="796"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="815"/>
            <end position="825"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAG5092942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="848" mass="96117" checksum="6A17F668E1AE35B3" modified="2022-05-25" version="1">MVMPVGDYRLYRNYNNIYFQSSSEGIPPNPAPAAVIPQPPGFPTATPGFVAPMIPAASFIPPSLHSTSGPTGIIPSQYSIPPPAYGFPMSAPPHHVHHHEAGVIDELKTPNELLLSQCPWKEYKSENGKIYYHNVATKESRWTIPSELEDLKNKIIADEANAGTKSAPVIDGDAPLPTSKSSQDSTNGNKSAIDQAIEATLAAIDIPTPPNTISTTTANSTTAATTSTAPSSKLVAADEDSNNSAKGSANGASGAGSRTSTPEPKLQFKDKKEAIEAFKELLKERDVPSNATWEQAVKMIQNDPRYPQMKKLNERKQAFNAYKTQKLKEEREQERLRLKKAKEDLEQFLLDNEKMTSYTKYYKCEEMYGGMEIWRAVGDPDRRDIYEDVIFNLAKREKEEAKQLKKRNIKKLAQVLDTMTDVTYRTTWQEAQALLLQYSPFAEDAHLLEMDKEDALQVFDNHIRQLEKDEEEEKEREKKRRKRQERKNRDGFISLLDELHEQGKLTSMSLWVELYPMLSADLRFSTMLGQPGSTPLDLFKFYVEDLKSRFHDEKKIIREILKDKGFDVQVNTTFEEFATVVCEDRKSATLDAGNVKLTYNLLLEKAEAREKERVKEETKKFKKLEAAFKTLLKSLPVDYQMSWEDDVRPKIEDSGDFKAIGSESERLRIFKEYQHELEESCSHHHIRSKKKKPKKVKRKSRSRSPYSEQSAANDDNERGKKKRMKSRSLSVQSKSDDSSESTAESSSKRSKRPRKSKKKRARSHSRSHSRMPSSEEDTPPSERKRKEEKRARSGSAVAAAAAAAAAAVEAPANGGHKEVSQHQELSEDELENKRAQLLRELQMQQEDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HBS1</accession>
    <name>A0A8J2HBS1_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS5100</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5089093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HBS1"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5089093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="82" mass="9607" checksum="CCAF08E892590390" modified="2022-05-25" version="1">MSMSNDRCDTPSKILKQLKIKLLIYLRKNMNFCQHRFGFTKLNKLLEGPSVQMGQELFRSECTYKKLQLNKSNYGPGIIIQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HCP4</accession>
    <name>A0A8J2HCP4_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Similar to gar-2: Muscarinic acetylcholine receptor gar-2 (Caenorhabditis elegans)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">HICCMSTLAB_LOCUS5585</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5090324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HCP4"/>
    <dbReference type="OrthoDB" id="10071887at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030425">
        <property type="term" value="C:dendrite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016907">
        <property type="term" value="F:G protein-coupled acetylcholine receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004993">
        <property type="term" value="F:G protein-coupled serotonin receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007197">
        <property type="term" value="P:adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007187">
        <property type="term" value="P:G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15302">
        <property type="entry name" value="7tmA_mAChR_GAR-2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000221">
        <property type="entry name" value="Muscarinic acetylcholine receptor gar-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24247">
        <property type="entry name" value="5-HYDROXYTRYPTAMINE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24247:SF191">
        <property type="entry name" value="MUSCARINIC ACETYLCHOLINE RECEPTOR, B-TYPE, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 10" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="7 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 10 14" id="KW-0675">Receptor</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 10" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 10 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="64"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="100"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="138"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="180"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="225"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="791"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="829"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="13">
        <location>
            <begin position="80"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="295"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="468"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="621"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="694"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="338"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="470"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="483"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="524"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="627"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="700"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="734"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="771"/>
            <end position="785"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CAG5090324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="870" mass="95419" checksum="2F37B660EA02A0D0" modified="2022-05-25" version="1">MSAECIQLNGTWLDSNDSRFSGEYSELLPDWFWNNITNITNASQSEDLLEVDEYTLPFELWQTVLIALCLAACIVLTIGGNILVLLAFIVDRSIRQPSNYFIASLAATDMLIGTVSMPFYTVYVLMGSWDLGPLLCDLWLSVDYTVCLVSQYTVLLITIDRFCSVKIAAKYRSWRTKNRVIWMVTITWIIPALLFFISIFGWEHFVGYRNLKPNECAVQFLKDPIFNTALIIGYYWTTLVVLFILYGGIYKTAYDMQKKSEAKQRKMQSMVALSAGAMSGMAGRAAGIGISKTQSTILSQDKPKDPSGGTSSTSVDNAPGSGDDLKDGNYTGTGRKLSGQQSQNKDSNNKLKSGTTSSEMERSERSSSPAFDSDDDSAVAVTSQQSAVRKRSSIAGLMVQAGAVHVFTSNNRLNGMVPINVEMNPMMKKMPPTSPLLDSASKAHTLPKIQEYSLADIENTIENTCEYEKSSTTLTPEQSLRSNEIDLNHSIERIEDTPPSEIRNKSSSSGQPSIIPPPTQFLGSPSVSESTSTSSSIDKTKSLMAHGAGTYDIMTGLDGADLRYMDESSIIVPSPSYESPPSSFSLSLANPLSTAPSSPVLGHSGTSAVNTSLLQAALIRAAAQHQSGTTPTQPSHNPQVTHASSQTNPPRVFVTHQINAASQTSPTVVSKVNTEVTVKVEDIKRQPITTVVSTSIDSSNNGTTTDQKLNNQPQVSSSSSALPTVVAVTVINQDPKRQSKKKDTDKEIETSSGSRRDFVKSIGRRLKAKTQKKDPTIGRQKSRTENRARKAFRTISFILGAFVACWTPYHVMALVEGFCSHRPCTNEHLYMFSYFLCYANSPMNPFCYALANQQFKKTFTRILKGDFHMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HCW9</accession>
    <name>A0A8J2HCW9_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Similar to l(2)efl: Protein lethal(2)essential for life (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HICCMSTLAB_LOCUS7246</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the small heat shock protein (HSP20) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5093920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HCW9"/>
    <dbReference type="OrthoDB" id="1431247at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042026">
        <property type="term" value="P:protein refolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009408">
        <property type="term" value="P:response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06526">
        <property type="entry name" value="metazoan_ACD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002068">
        <property type="entry name" value="A-crystallin/Hsp20_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001436">
        <property type="entry name" value="Alpha-crystallin/sHSP_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45640:SF13">
        <property type="entry name" value="HEAT SHOCK PROTEIN 22-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45640">
        <property type="entry name" value="HEAT SHOCK PROTEIN HSP-12.2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00011">
        <property type="entry name" value="HSP20"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00299">
        <property type="entry name" value="ACRYSTALLIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01031">
        <property type="entry name" value="SHSP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="SHSP" evidence="4">
        <location>
            <begin position="21"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="SHSP" evidence="4">
        <location>
            <begin position="214"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS01031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAG5093920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="351" mass="40387" checksum="1995738ACAC456E3" modified="2022-05-25" version="1">MPVNNIYFPASSYRNYQHPLFDVAYQRSRFITPKYRDEDKFTVTLDVAQYNPDDIAVKVVGNVIIVQAGDEYELDEFGTLSREFERKYEVPEEYNVDEAKSELSSDGVLTIRVPKKESESGRPILIEYLPYPAVIEVDPNVAEVERPRSPNRLPLLFSNWWEDLEAPHRLLDQDFGLGLSPDQLMPPSVVERYLVPRAADRRRHPLAYYRPWAELLRKADSGASTVKADKDKFQVILDVQQFQPEEINVKVVDKCVIVEAKHEEKQDEHGFISRQFVRKYMIPEQCDIDQVNSSLSSDGVLTITAPRKDIPKVEGERSIKIEHTGKPAIRETCEKDACAKECKKDDKKGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HCY9</accession>
    <name>A0A8J2HCY9_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glutaminyl-peptide cyclotransferase</fullName>
            <ecNumber evidence="4">2.3.2.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">HICCMSTLAB_LOCUS5106</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Acts as a glutaminyl-peptide cyclotransferase. Responsible for the biosynthesis of pyroglutamyl peptides. Might be more efficient in the conversion of tri and tetrapeptides in vitro. Might have a relative preference for substrates containing hydrophobic amino acids in vitro.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>N-terminal L-glutaminyl-[peptide] = N-terminal 5-oxo-L-prolyl-[peptide] + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:23652"/>
            <dbReference type="Rhea" id="RHEA-COMP:11736"/>
            <dbReference type="Rhea" id="RHEA-COMP:11846"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:64722"/>
            <dbReference type="ChEBI" id="CHEBI:87215"/>
            <dbReference type="EC" id="2.3.2.5"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glutaminyl-peptide cyclotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.5" evidence="4"/>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5089105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HCY9"/>
    <dbReference type="OrthoDB" id="3907302at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016603">
        <property type="term" value="F:glutaminyl-peptide cyclotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03880">
        <property type="entry name" value="M28_QC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.10:FF:000029">
        <property type="entry name" value="Glutaminyl-peptide cyclotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037457">
        <property type="entry name" value="M28_QC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007484">
        <property type="entry name" value="Peptidase_M28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040234">
        <property type="entry name" value="QC/QCL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12283">
        <property type="entry name" value="GLUTAMINYL-PEPTIDE CYCLOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12283:SF6">
        <property type="entry name" value="GLUTAMINYL-PEPTIDE CYCLOTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04389">
        <property type="entry name" value="Peptidase_M28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0964">Secreted</keyword>
    <keyword evidence="13" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035320356" description="Glutaminyl-peptide cyclotransferase" evidence="13">
        <location>
            <begin position="20"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M28" evidence="14">
        <location>
            <begin position="111"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00016861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00057903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF04389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CAG5089105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="348" mass="39741" checksum="DEF465D7B115EC43" modified="2022-05-25" version="1">MSRLWLNFCLLSFVTSVAPQSNLSASFRNAKFEHSAKTLSNSEVRTLASLSNVSHVEEVLNEICIVRVVGSLNHAKVKNYIKRTMRNLGWSLETDEFYDVTPTFGKLRFENIITTLNPNAKRYLTLACHYDSKYSREGNFVGATDSAVPCAQLLNLATVMQKQLEPLKHAELSLMFIFFDGEEAFDTWGPTDSIYGARHLADKWHSVKQTYGDEDDISNLDKMDVLVLLDLIGATDPNFYNFFDSTVRWYSQLILAEKSLADLSLLKNYFGHIPSRKYFQPQSVNSYIEDDHIPFLKKNVPILHLIPHPFPDVWHKPSDNLQNIDLTTTENLNKILRLFVASYFGLSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HCZ5</accession>
    <name>A0A8J2HCZ5_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS5569</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5090279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HCZ5"/>
    <dbReference type="OrthoDB" id="7617070at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579">
        <property type="entry name" value="F5/8 TYPE C DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579:SF1">
        <property type="entry name" value="F5_8 TYPE C DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5090279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="144" mass="16874" checksum="B072B280CA63AC74" modified="2022-05-25" version="1" fragment="single">MKGHNGTFGCCHCKIESKYFNRRRIYPFKPNLSPRTTKESIDDVDGIKGPTVLTQIVYDVFNTTVVDSMHCVYLGVVKRAFSLFFECSYSHCKLSLYEHLKFVDSKIRSISPPGFVSRLTRSVFDFKYWKASEWKQWLLYYSIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HDS7</accession>
    <name>A0A8J2HDS7_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Similar to Neogenin (Gallus gallus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">HICCMSTLAB_LOCUS6354</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the immunoglobulin superfamily. DCC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5092755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="114660at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009653">
        <property type="term" value="P:anatomical structure morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098609">
        <property type="term" value="P:cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000004">
        <property type="entry name" value="DCC isoform 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000133">
        <property type="entry name" value="Neogenin isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000028">
        <property type="entry name" value="Neuronal cell adhesion molecule"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000551">
        <property type="entry name" value="Protogenin A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010560">
        <property type="entry name" value="Neogenin_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44170:SF54">
        <property type="entry name" value="FI24025P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44170">
        <property type="entry name" value="PROTEIN SIDEKICK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06583">
        <property type="entry name" value="Neogenin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00014">
        <property type="entry name" value="FNTYPEIII"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="6 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="12" id="KW-0732">Signal</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035233185" evidence="12">
        <location>
            <begin position="21"/>
            <end position="1634"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1201"/>
            <end position="1226"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="13">
        <location>
            <begin position="24"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="13">
        <location>
            <begin position="127"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="13">
        <location>
            <begin position="236"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="13">
        <location>
            <begin position="330"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="14">
        <location>
            <begin position="567"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="14">
        <location>
            <begin position="667"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="14">
        <location>
            <begin position="774"/>
            <end position="868"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="14">
        <location>
            <begin position="875"/>
            <end position="968"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="14">
        <location>
            <begin position="979"/>
            <end position="1077"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="14">
        <location>
            <begin position="1082"/>
            <end position="1179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="426"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="498"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1282"/>
            <end position="1311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1367"/>
            <end position="1398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1444"/>
            <end position="1582"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="427"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="498"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="524"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1367"/>
            <end position="1388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1444"/>
            <end position="1462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1472"/>
            <end position="1492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1536"/>
            <end position="1577"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CAG5092755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="1634" mass="179188" checksum="97F1C49483A34B5E" modified="2022-05-25" version="1">MDKFIGVCFIISGLVTSGLCAAGLDLIVEPEDVIVEPGGAARLDCQASSTVYDASAINIQWRTEDGQMVNFIGDSYRSQLANGSLYISSVYADNSESTGGYQCLVTVENVGAVVSKIATISLLSQLPAFKEEPRDIAVSLKQTAFFSCSLLTTKLLENRVKIQWLKDEHPLQLDESRMTIMPSSGALEIDDVRHEDVGSYRCNATAFNQYRLSNKAQLTLLQESPSLSTDLDQQSPPVFIAKPKAQIAVEGATIILECAANGRPKPSILWLKNGVAVDLATLDSRYRKIAASSLMITDIMEEDTGSYQCRAKNDVETLDAVAEVTVQVPPRFIKRPEDKVASENQDLEFECDIYGKPEPKVTWLKNGEKITLSEYWQLVNNNNLRINGLLPIDAGIFQCIGTNPAGSIQTFARLVIIHKPKKGHLAKSPSITLSPKSLPKKKLSHQRQLYNNTWQHPSTLLGHTLSAFTSSSPELSSNSYPGDDSADLFFDKISEADTEGDLDPDSDFDSDSDPDETLLPPPPSRHHHHHHHHYHHHQQKPESHFLDNTDNLDLLEGAGSNGPILLAPKNLSVVIVKTRFVTLRWQKPENADSDSSLTYHIYYKQDGSQRERVVITAQRQLEVVVRGLQPGVTYQFRVVAHNSQGIAGASSEVLTVTTHSEADVPSPPLNLEGHATSSQSIKVSWQEPKILNGRISKYVVTAMENTDDIGGSIGAGGFSEGERIRETTSTTCELVDLTPYTEYSIWVYAVNENGPGASTGEINLRTFSAQPSHPPHNVTLEAASSTSIIVRWEPPLEGQNGIITGYKIRYRRQDRRYHSNTITTEGNTRLHVISGLEKHGVYHVRICALNVNGTGPWTEWMAIETYENDLDESTVPSAPTNLRTKALSTSISVWWSPPKDDRIKVRGYIIGWGKGYPDVFNQELDGKQRYYSIESLDPMFEYVISLRATNEAGEGPPIYANVRTIEKTAVESTVTPLIPPVGLKAVVLSANTVVLYWTDTSLSGGQRISDNRYYVVRYAPYHPLTLSPRYKYFNASDLNCMIDDLKPNTQYEFTVKTVKGKRESPWSMIALNQTHEAAPTSSPRDLTVQSYEDRSTAVIVHWQPPKQPNGHIIGYIISYSTDNTKRERDWHVEGVLGNKTEYIIKGLKPSTTYYFKIQGRNIKGYGPFSSIVVFKTPLSNGMDYDDFYSQQQQDGRGLSQVLIYIIIGCAVILITGVAVVVIFVCCRRQNESPDRKKGYMKDVNQKTNIKPPDLWIHHDQMELKALEKSSINGETLTSTASGGIVNNTLPRSGNTDYNHTDTSGNTVINSGSLDKRTYVPSYMATNNLDDKCSTLTRQHSRSKSKFIPLTVVDSGGPLHSSITPGTAASTTIVSSGHGNSLSQPTIFNSSDGSRESSRSIYPRTVGAQYSLSRAHITLEPTPESNASADLSSMSSNYEQLHHNSITYGSTPYNNSTSSQQFTPGHYGGGNTSQSSVAANSSSIISGGNSSRGELGGGSGSGTESNANSGGGSGSIKRLQGHPLKSFSVPAPPPQSAPSTPAQQKHVTQVSQVTVRSSLSGSPYKKQQSGSSSAATSTNQLTKNRLASVSNACHTPEEIERLKPSYSTEELNQEMANLEGLMKDLNAITASEFKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HDV8</accession>
    <name>A0A8J2HDV8_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Similar to Vipr1: Vasoactive intestinal polypeptide receptor 1 (Mus musculus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">HICCMSTLAB_LOCUS7837</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G-protein coupled receptor 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5095696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HDV8"/>
    <dbReference type="OrthoDB" id="16753at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008528">
        <property type="term" value="F:G protein-coupled peptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017046">
        <property type="term" value="F:peptide hormone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007188">
        <property type="term" value="P:adenylate cyclase-modulating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007166">
        <property type="term" value="P:cell surface receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1240.10">
        <property type="entry name" value="GPCR, family 2, extracellular hormone receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050332">
        <property type="entry name" value="GPCR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017981">
        <property type="entry name" value="GPCR_2-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036445">
        <property type="entry name" value="GPCR_2_extracell_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001879">
        <property type="entry name" value="GPCR_2_extracellular_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000832">
        <property type="entry name" value="GPCR_2_secretin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017983">
        <property type="entry name" value="GPCR_2_secretin-like_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45620:SF1">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 2 PROFILE 2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45620">
        <property type="entry name" value="PDF RECEPTOR-LIKE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00002">
        <property type="entry name" value="7tm_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02793">
        <property type="entry name" value="HRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00249">
        <property type="entry name" value="GPCRSECRETIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00008">
        <property type="entry name" value="HormR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111418">
        <property type="entry name" value="Hormone receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00649">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50227">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50261">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 14" id="KW-0675">Receptor</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="100"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="220"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="260"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="307"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="339"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 1" evidence="12">
        <location>
            <begin position="16"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 2" evidence="13">
        <location>
            <begin position="95"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="14">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CAG5095696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="401" mass="46958" checksum="A9E79244C2634AD1" modified="2022-05-25" version="1" fragment="single">MIMDNIDEFIENQKNFCHQLMEDHVKVNLTNHCPPFFDGLLCWPPSNSNQTINLPCPPLYVLGYENPHGNAVATKYCNIYGEWYRNNEGTWLPIIKTISIIGYASSFLTLIAAMTIFLFIRKLQNSRNRLHMNLFSSFIMRASMALLKDWLFVDGVGLSWNVVSIDGKSAYIKEKNIWVCKVITSLWQYSIVANYSWIFIEGLYLHNLIFFSFTDTSAITCYTVFGWSVPLAVVIIWIILRIIKEDTLCWTTHNNQSFFLIIRIPIIISIMLNFVLFINIVRVLLIKMKTSVYLQRKKMQYGKWAKSTLVLIPLFGAHYAIFLGLSYHRDYQLELIWLFWDQFFASFQGSVVALLYCFLNGEVRAELKRTWRIRRSRRGVDSLSFSNRNLIKSPELRNQHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HEW1</accession>
    <name>A0A8J2HEW1_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to ORF1: Nucleic-acid-binding protein from transposon X-element (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS6751</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5093329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HEW1"/>
    <dbReference type="OrthoDB" id="7989680at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071897">
        <property type="term" value="P:DNA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052560">
        <property type="entry name" value="RdDP_mobile_element"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36688">
        <property type="entry name" value="ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36688:SF1">
        <property type="entry name" value="ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14529">
        <property type="entry name" value="Exo_endo_phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="2">
        <location>
            <begin position="574"/>
            <end position="925"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5093329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="932" mass="106881" checksum="1087E91FB4B48438" modified="2022-05-25" version="1">METDYGIDETNEQLKSTQDTTDNASQNTETTNAKTYRPPPIFVQGEKAIDTIQALRIANIDQETFSITMSKGQHQLLAKNQLSFEKIKVVLIANNFNFYSFTPKSEKLKSLLLKSMSPDVTTDMVFKDLTEKNIPSVVFKKVSELKFMRDDEPRRHLIVQRLRRNRALQCRKCQRLGHTAANCQMEYRCVRCGDSSHAPAQCPLKDEKTRDKFKCANCGKNGHPASYAGCRFMKFEKISRNQARAQKNKSLERNIEAIYREVTPQISFANAMSPSRDPFPPLKHRNQTNFQTFQEGPPPPPVIENTRSQAFRLQPEYHQQQSQWPRDENPQQQNWANITNQISELTNVIKEMSININRSINENTRKINFLFAYFNNTDSNKKIFVISSYATNSNRKTFIQELDDVLQRLDLSNADHFFILAGDLNTRRMEWGDTADNQRGKFLRTWEAESIDAYRSSIYTTDVASFKTGSFLDVCISNITLTGLTSKNKITTAYYDSDHRALLFTAILSHEVQTGADIQIPWRNLQEIDDGITNLTSALVNTINKTAPIVKKNEGILKYINAKIKKLQKNKTKAINLLHVSINSTSPNKLELIQKTKHTINLIKSELRKEFNKSVEDYWKGQLKQINHKDPTSFFPKINRFLRKKNRISIADQRIKINDPVCQSGAIDVIKAIKIEDELLITEPIDKLNVIGEFYQTINAPRYLNTGTKLKELIDKKAGEAKELLSTRRSEDTTITNFSKDNRALNPANDGLIIPNHLNNKKSNSSAQTQKEHPFVTYDQLTKILRKLPNKTSKGLQQGTVNSPLLFNIFTMALLQLFNLNIKENLFAVAYADDIIVGVAGKNPPKLQNELEKLVNNINDYYKIWNLRMNPEKCEIAVFRRESNHLSKKALTQIKDFQISTPSPNTNEMIKIPHKTVVKYLGVHIDQLLRIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HEW4</accession>
    <name>A0A8J2HEW4_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Cytochrome c oxidase assembly protein COX11, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HICCMSTLAB_LOCUS8719</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Interacts with CNNM4/ACDP4. Interacts with RANBP2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
            <orientation evidence="2">Intermembrane side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5097461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HEW4"/>
    <dbReference type="OrthoDB" id="1704689at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.370.10:FF:000001">
        <property type="entry name" value="COX11 cytochrome c oxidase assembly homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.370.10">
        <property type="entry name" value="Ctag/Cox11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00155">
        <property type="entry name" value="CtaG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023471">
        <property type="entry name" value="CtaG/Cox11_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007533">
        <property type="entry name" value="Cyt_c_oxidase_assmbl_CtaG"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003465">
        <property type="entry name" value="PRK05089.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21320:SF3">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY PROTEIN COX11, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21320">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY PROTEIN COX11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04442">
        <property type="entry name" value="CtaG_Cox11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110111">
        <property type="entry name" value="Ctag/Cox11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="46"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00063165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00068998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAG5097461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="230" mass="26187" checksum="31F077BBDF606A92" modified="2022-05-25" version="1">MLMRFINSVCRKYPNRQFFTNTVKFAIREPTEEEILRRNKLKTSHYLTALGVVSVGLAYAAVPLYRVFCQATSYGGTVGHDASMVDSMKPVRDREIRVVFTADTAAAMTWNFKPQQKEIKVVPGETALAFYTATNPTDKPIVGISTYNVVPFEAGQYFNKIQCFCFEEQQLNPHEQVDMPVFFYIDPEFAENPLMENLSDITLSYTFFEAKKGFKLPIPSYVKPHTTPSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HEX5</accession>
    <name>A0A8J2HEX5_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Core-binding (CB) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS6299</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5092667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HEX5"/>
    <dbReference type="OrthoDB" id="7701645at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010998">
        <property type="entry name" value="Integrase_recombinase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35617:SF3">
        <property type="entry name" value="CORE-BINDING (CB) DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35617">
        <property type="entry name" value="PHAGE_INTEGRASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47823">
        <property type="entry name" value="lambda integrase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5092667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="165" mass="18680" checksum="EEB475C55900E9BD" modified="2022-05-25" version="1" fragment="single">MFSQAWSSITSDSFILSTISGYKIPFLSTPVQNSEPPEFSGSDSDVLAMSEASSTGREINAVGREIIWESFKSRGIKEDSIKLLMSSITPSTKKQYEKPIREWVSFCKKNNYNIFSPNEQEVMEWLVEKFNEVLSYSSLNVYRSALSFLCGDFIGKSPLICRLLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HFD7</accession>
    <name>A0A8J2HFD7_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Similar to WDR7: WD repeat-containing protein 7 (Homo sapiens)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HICCMSTLAB_LOCUS8791</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5097615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="338622at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049916">
        <property type="entry name" value="WDR72-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44099">
        <property type="entry name" value="RABCONNECTIN-3B, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44099:SF4">
        <property type="entry name" value="RABCONNECTIN-3B, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="448"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="544"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="794"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1062"/>
            <end position="1111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="802"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1073"/>
            <end position="1087"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1088"/>
            <end position="1111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAG5097615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="1482" mass="164939" checksum="46D440E9E60546AF" modified="2022-05-25" version="1">MTDEGSLVVPIVLWGKVPPTHCISCMYLSRDQKTLVTGCYDGHVCLWQVDPETLKMTPRSLMVGHTGAVMCLSRASDVLELDYIVSCSENGEMCTWDLVNGNCRENVKIAYIHTQMYYPEVLVMDPFSLEILYTLSSRVNPDWISALQVLRPAKRKGRFLVHTNDVVLAITTTGTVKVWSLFGKEQQTKEPIYENESKQIKCMNALAMTCCAYNHRTVLLVSSGSWQVYDAADFSLLCSVNAPQKERWVAGDFLSTDQVLIWTDEGHGYIYKLPSNSVAENHDFHTSSIESDQPYSFCTLSYPGEKPLSCPPTMKLVTATRQNKPVKYLIRGDSEGVIMIWTVPEMTVQQIAEINKSDSVPIMPPSIITSLSAAWEAMKPPPVGILDQMDTGESIKLTACIYLPQQSRLVVGREDGSIIIVPATQTVMLQLLHGNHQHFDDWPPHQVLMGHSGRVNCLLYPHSHSPRYDRTHLVSGSVDFAVCLWDLYTGNMIHRFCVHAGEITQLTITPDNASPRIQKCICSVASDHSVTLLSLAERKCVVLASRHLFPVTTIKWRPLDDFMIVGCSDGAVYVWQMETGHLDRVLHGIIAEEVLFACSDNTIITGDATAGGELGLANPAVHFFRGLRHRNLSAIRHATQRGLHQLQQLHGGHGDHHDSQLKTKDYPLNIEGFRGNPKDPEGHILFFNVETLIVQLLSDEYGSMSPGSLEAQGLISASEYQKVAALTQSASPDAHKKIADFFGRVKDKAGDVEKLLKEKDRHGILAKMKEGAENVHTKLQAKAESVGLKPLNLDGKGEGWNNGDSRNTLKRNGNFNEPNATMEIAQLLLSLLHAWGMDPDLDRVCESKLGLLRPLVPVSFGVICKSSYMTLLLPTWHQQLDLKIEPTQLEQRLPIELVRQDRLTKAFTARAHWELSTTLTSNHLLTVVALANTLMSMNNATFVPEQERNRKMHRPGNRAGVNWNKAEEENEEMYTVQQAQIKQGWSLLATLHCVLLPDKVAALGGVKTFKRPLVEMMACRWQDQCLELREAAQALLLAELGRLGPKGRKSLVDYWAQYLPKDPPKESAPQQQNHSHSPSSSSPVPNSDSKKSDSESNHEGNHADEICNSRRPNEAEIKTKEHTAIVLLGVIGAEFGQNVSTTGNQRRDGERRKSSVVEGFGIGNNNLARLTSMSLMRLLLDPRQFNQQTHSSLRRAAIDLIGRGFTVWEPYLDISKVLLGLLEMCCDADKLVPSMTYGLPLTPQADTCRTARHALTLIATARPAAFITTMAREVARFNAIQQNSQTLNVNVNSNILARAKPEILRIVEQLIDKMQSEMSDLLVEVMDIILHCLDPGHLKTKPLNEVFPAVCRFNQVSHCSASRRIAVGGRVGQLALYELRGTVKCQTVSAHQASVTALAFSPEGKFLVSYSCTENKLCFWQQTSSGMFGLGNSQTRCVKSYSTAPMNDVTRLNPMRLARLIWINNRTVTLMLADGSETRFNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HFR4</accession>
    <name>A0A8J2HFR4_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Similar to Slc6a19: Sodium-dependent neutral amino acid transporter B(0)AT1 (Rattus norvegicus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HICCMSTLAB_LOCUS7293</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5093967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HFR4"/>
    <dbReference type="OrthoDB" id="6366319at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005283">
        <property type="term" value="F:amino acid:sodium symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0089718">
        <property type="term" value="P:amino acid import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000175">
        <property type="entry name" value="Na/ntran_symport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037272">
        <property type="entry name" value="SNS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11616:SF323">
        <property type="entry name" value="SODIUM-DEPENDENT TRANSPORTER BEDRAGGLED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11616">
        <property type="entry name" value="SODIUM/CHLORIDE DEPENDENT TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00209">
        <property type="entry name" value="SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00176">
        <property type="entry name" value="NANEUSMPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161070">
        <property type="entry name" value="SNF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50267">
        <property type="entry name" value="NA_NEUROTRAN_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0915">Sodium</keyword>
    <keyword evidence="5" id="KW-0769">Symport</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="321"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="364"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="450"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="482"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="529"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="564"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="678"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="709"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="734"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="784"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="824"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="165"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="230"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="908"/>
            <end position="936"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="9"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="54"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="187"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="230"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="255"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="908"/>
            <end position="920"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="924"/>
            <end position="935"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="299"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="306"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="670"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR600175-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAG5093967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="1127" mass="123772" checksum="4B5747D2776C5F8E" modified="2022-05-25" version="1">MYTPTSVAPLDSSGTTSLPTPLTALESPSSPSVAAGVTVTYTQERTQSQKRMRSSTGPVASSDGHSNSSITMPVDPTPAKSISSNLVTADTLPEDFSISRDLNFLGNGTSTSTATSTSTSTTSNSTPLSFELDQIDHEDAGIPINNSPASGSSWMRASMRRLRHLRLPQGSTRQRTHRPLTVDAIESSSFTTTSTSSSASSSSASSSRPISAPNSLPDIALIAPEILAAHTNSNPGNSNSNLRPSSAPVARRQRPSCDRQRDGSRRTGGGGGGNEDEESDENPLGKWPHALSPALACLGCTLGLFNISRFSILSVQFGANFIVQFLVLSLVLGIPLLTLQVCLGQRLAAGAVDMWKISPVFHGVGIALLVAHALIGIYSIIGVSWMFVYFRDSFITKQDRYRWAEPFFLYREDAKPMNLTVSYKLHETVPDYFSGVVLQRHHLNEPSPGIVTLKFQVAFNLAVVWMIVFVSLSKGLRSYGKVVYVFTLVPVFGTLILCTKLLGLTPPGTINQLFPATVWSEFFINSKSWVAASSEVFLTWGVLGAAAMQIAAHNKYKNLLQRDTSLVIVLTIVVLLLSAFLANTCVQILRYHGYTYTTSSFEKISSYVFMRPINQAPPPGYGNTPERFMSHASFLLGQRTIKPGADLTAESGYQSLRLSTELVPATLALLGAEQVSPFWAVLFYFILILFGIAQQLWETTITFFSCACAYILGLPMATELGIYVVYYLDYTIGGGWWIIILYLVQVGAVFAVRGRPHTGEAVVAELFSPTGRCLKHWAGPLLSFTWNVILPIMLMVLSITLFRSSNFRELYSYRRNGKDYWAVWSRQLGAAMQLIPILIIPAVAIIQTCRYLNNGPPDIFDTEQTETNDHCEHCNGNRIQLLYRPSLEPESARRRLTQLRNNTTTSIHQDTTGILPTTSDVPFEDPPPKYTPPPSYTTATGARIAKMLRQSFRQSVRRIASVLGESSVARTRPALQPPPPDYATVLVEMNHTIVSRDIPVIHTIESRPDVADVNPISHRHSHSHSGPIMDIRIGSQTLDRVSRNTFDRCPVERTHSTIDRNRRRLHNTGSSNLTAADVANLLRSSIRRGTNKTHQTLQRNSLLNHQPAPPINAASIENLMKINSADI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HG35</accession>
    <name>A0A8J2HG35_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to Focad: Focadhesin (Mus musculus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS9291</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5099901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HG35"/>
    <dbReference type="OrthoDB" id="6354723at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060147">
        <property type="term" value="P:regulation of post-transcriptional gene silencing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022542">
        <property type="entry name" value="FOCAD/RST1_DUF3730"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045163">
        <property type="entry name" value="Focadhesin/RST1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16212:SF4">
        <property type="entry name" value="FOCADHESIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16212">
        <property type="entry name" value="FOCADHESIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12530">
        <property type="entry name" value="DUF3730"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="269"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="304"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3730" evidence="2">
        <location>
            <begin position="446"/>
            <end position="668"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5099901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="1181" mass="133576" checksum="5CC1152B9E30D0FC" modified="2022-05-25" version="1">MDEIEYKLSSNNSILITHIPELKSLFTKCKSENAIVSLVSCHAVVALAESGLIEVSETLSKLSAMLGETKNYSAVTSAICSLLTLILKSHSGNYECPFSIQAPQHPLITVLNEKADSWRSVLGDIKSMLHDCKPKAVRNQVELLRPVFVYIIANPTNSSLENCRQQAWSLLIRTPDALELQLEIIQWLRTINLSSCITTNNLILEFTELAVTKKNVKLFSALTPLVMALALDLLKHNCDPRSNIVMIESILECTGTEDINQFNFMHESLISSVILSILSEMLVITPVIYLYDLIKIAASIVNKLGCNEIVAYSLLGSILPWMAYATPLSSEALEIADNLITTITTKTFTRNKYPENIYNDNLYNYLSHSSRYVQFYTNLCVHIESCVNLNTCLDKLSNISKEFLYNYKLILGGIFLSSKSTETILKAINLLVRIAKENNSYAGHVLSMLLYKLSKSKEIEVTKKLLYILPELAVSKENVPIIIQTLQTFLAADKPLKYVGVNLFLKAWMVEPRCHRYLMTGLIDMSSNDKSMQANITCAKAMVFICENRPEHGAELVPLLSQILNRCGDIDGSAASALALRGISALCDAGIADICSTWRVLAPKMNKEDRSIVIKSLCDFFATVPTNSPYPEDQFEELVDESLTKLWELTSFETTRNLEIIEAAFKALSAYTISQIKISVLPEVFLKDLPASKVNSEEPKIEMAFTYVPSTCWITMLETIHEPALSLAGNLIIKFITDELYGFKTGIYMWAMGEPINFKYLPEKSPVRAIGEYLRRFSTENLNTEKKKIMMECLRIFSYKYPKPLPPIKWELFTKAINVSPESWTAGITLACHQAAVSPSAKEFLSKYLTKMTEKCDNSDVTITSKEFKECWHLCTHLDDISRGVTSGVLAPFLDVTLNCIIDKAMVNDETAVDMFDHLMGFYSKTLKDDLVHFDNKTLIFGILEKLFDKIDVDSKIFEAYTKALLEMTAEKIERITLPNVWEEITNDKLKKAIIIRAGLVLKRDNEIPLSWMNEIIRVSSSEPGVQKCLLSNMKKIQSKLLTEKSNATWSWDLMCRIQATIVNSHDNYSLETTTSLCDILFVTIIVLACDDCFIENYESLITSHDIRIQLFPHAMATIILMPFWKDITQQIMEWLNFMRNSTLPTSYKIVFHNTLVSLKEQRHLNDLWPKYLSVKSPIQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HG41</accession>
    <name>A0A8J2HG41_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Sodium/hydrogen exchanger</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">HICCMSTLAB_LOCUS8005</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5096029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HG41"/>
    <dbReference type="OrthoDB" id="196264at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015386">
        <property type="term" value="F:potassium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015385">
        <property type="term" value="F:sodium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051453">
        <property type="term" value="P:regulation of intracellular pH"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098719">
        <property type="term" value="P:sodium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1040">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018422">
        <property type="entry name" value="Cation/H_exchanger_CPA1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004709">
        <property type="entry name" value="NaH_exchanger"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00840">
        <property type="entry name" value="b_cpa1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10110">
        <property type="entry name" value="SODIUM/HYDROGEN EXCHANGER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10110:SF98">
        <property type="entry name" value="SODIUM_HYDROGEN EXCHANGER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01084">
        <property type="entry name" value="NAHEXCHNGR"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0050">Antiport</keyword>
    <keyword evidence="6 9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0915">Sodium</keyword>
    <keyword evidence="8 9" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="3 9 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035247661" description="Sodium/hydrogen exchanger" evidence="12">
        <location>
            <begin position="29"/>
            <end position="1039"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="145"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="175"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="204"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="232"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="266"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="295"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="339"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="370"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="392"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="456"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="495"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="525"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="domain" description="Cation/H+ exchanger transmembrane" evidence="13">
        <location>
            <begin position="152"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="34"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="100"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1011"/>
            <end position="1039"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="101"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1020"/>
            <end position="1031"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CAG5096029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="1039" mass="116712" checksum="AAF45C24BAC35DE1" modified="2022-05-25" version="1">MATHEKSTRCVLTLVLLLFASDVLHCAARSYDDTRRLGSSGDDNNDGSVIQVLPMHGPSADNHDLPQDLGKPYPGKSFGPMGPIDRTFLDESLRNLESGDDSGIVGGDDANSNQNSNGNANVGGHAKKREYKVFSVEFHRVETPFIIGIWIFFASLAKIGFHMAPKFSKMFPESCLLIVVGVVIGVLLFHASSVHVSPLTPDTFFLYMLPPIILDAGYFMPNRLFFDHLGTILLFAVIGTIFNTLSIGATLWVLGKSGLFGFTTPLLDMFLFSALISAVDPVAVLAVFEEIHVNEILYIVVFGESLLNDAVTVVLYHMFETYSEMGPSRITYMDLLSGLGSFLVVAIGGTIIGVIWGLATGFVTRFTNQVRVIEPIFIFVMAYLAYLNAEIFHMSGILAITFCGITMKNYVEANISHKSHTTVKYTMKMLSSSSETIIFMFLGVATVNNRHDWNTWFVVMTIVLCSVYRIVGVMVLTAVANRFRLHKLDKVEKFVMSYGGLRGAVAFALVLLIDPKHVPLQPMFVTTTIAVIYFTVFIQGITIKPLVKILNVKRAERRKPTMNERIHERIMDHIMAGVEDILGKHGNYHLRDKFKRFDNKFIRPYLVRNHYGAEPKILETYSKLAMKDAMDYIRRNASTIGNISGTESMSAIFRNYSNPGQFNSRWAVQKKLKISQHRVTPLLAKGSTCSSNFPFVHSSPSCSQLEAGWNIDLQELEYYPSKKDLTDAKIHHLLVEELCKPYKRHRRLSYSRHAVNDRDLSTQVNYKMHMNIRRMMGEHKHRHKRSKKILKDGSKQNHVSFPELQQQNGSTKLFSPDYIDGDLYKLEDEEEGKPTRDPDWDSAITFTARTSGESFRVTTPTATETMLPWKREDDYEDSARPVKQNEFPAWCSNKEYLAYSSPSATFLGGIEQPKVQSVIGLFRKDSGGSPDLAGYRDLDESDEFAGMGFTNGTFSPRTSDKLSKVKRRGSMMELSSAESIHKEKVNNNGSHSLPEYWNSQRLRLQQSQTTFPCSTANAPSLSTALISSSTESSEDYEED</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HG94</accession>
    <name>A0A8J2HG94_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS6858</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5093468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HG94"/>
    <dbReference type="OrthoDB" id="504708at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39069">
        <property type="entry name" value="ECDYSONE-INDUCIBLE GENE E1, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39069:SF8">
        <property type="entry name" value="FI17111P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035173670" evidence="1">
        <location>
            <begin position="22"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5093468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="363" mass="41393" checksum="95A893F7994F2CDB" modified="2022-05-25" version="1">MKLKLSTSVIFILMVVTFTTTQENSTPTTFLLGIDCSHDRNCTFQNSYCDNEFYRCRCRDNYYPANNQSVCIQYAQTLLGHCERAIGCKLMNNTECRKNACKCRTGFENQDGKCTPTVFNCIDDCEKNRPGRICKMGECNCDENTAYFEWNDTLHWCALYANRLEIDTCFGREGCRYLPNSRCTSYHKCICKKSYTQKDNRCLADINGSCTETSYCNVNNSFCNNWQQCECKYGYFPSNDNKTCIKYEIDGPCDYYNRCDSLSHAECVNGKCKCIKGSWSIEGLCIHSKDIYENSSDSIGDSKSYPCGNCTCTSVSYKVPKSCDKITNECIEEHNMDIVKMKCSSLAESGFDCQDPNKCKKLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HGD0</accession>
    <name>A0A8J2HGD0_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Similar to SDR-1: Farnesol dehydrogenase (Aedes aegypti)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HICCMSTLAB_LOCUS7147</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5093821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HGD0"/>
    <dbReference type="OrthoDB" id="1933717at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000047">
        <property type="entry name" value="NADP-dependent L-serine/L-allo-threonine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43115">
        <property type="entry name" value="DEHYDROGENASE/REDUCTASE SDR FAMILY MEMBER 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43115:SF4">
        <property type="entry name" value="DEHYDROGENASE_REDUCTASE SDR FAMILY MEMBER 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG5093821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="248" mass="27522" checksum="98F75E990264225F" modified="2022-05-25" version="1">MDRWVGKIAIVSGVSSGIGELLARELVSAGVNVLGLARRENKLQELSKSLKNTKGAFHYLKCDVRNERDIVDAFAYVEKNFGQLDILINNAAVLIDNSFENGKTEDYRSLLETNVLAPALFIREALKLIRKHKNDAYIVNINSICGLNATVVDLPMGLYPASKFAMTAMNETLKKEIKDNNDKIRVTAIHPGVTGTELFFSSELHRNIYNNTPYLKPKNVVDCIMFALSAPSHVQIDELIVTAVATKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HGR3</accession>
    <name>A0A8J2HGR3_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Olfactory receptor 236</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HICCMSTLAB_LOCUS9918</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5100845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HGR3"/>
    <dbReference type="OrthoDB" id="8185860at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005549">
        <property type="term" value="F:odorant binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004984">
        <property type="term" value="F:olfactory receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004117">
        <property type="entry name" value="7tm6_olfct_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21137">
        <property type="entry name" value="ODORANT RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21137:SF35">
        <property type="entry name" value="ODORANT RECEPTOR 19A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02949">
        <property type="entry name" value="7tm_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0552">Olfaction</keyword>
    <keyword evidence="8 10" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="9" id="KW-0807">Transducer</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAG5100845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="107" mass="12558" checksum="C87F9731F3C59275" modified="2022-05-25" version="1" fragment="single">VTVIMIFIALKNHDISSVIRDAAGTILYFFSQIFIYCYAGEKLNSAMQESCFSVYSCYWYNFPMKNCKDIKYIMLRTSQEFHLTAGKFYRMNLENFTSVVKTLVSFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HHK5</accession>
    <name>A0A8J2HHK5_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Mitochondrial (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HICCMSTLAB_LOCUS10258</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5101185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HHK5"/>
    <dbReference type="OrthoDB" id="9972728at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14870">
        <property type="entry name" value="uS7_Mitochondria_Mammalian"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.455.10">
        <property type="entry name" value="Ribosomal protein S7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000235">
        <property type="entry name" value="Ribosomal_uS7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020606">
        <property type="entry name" value="Ribosomal_uS7_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023798">
        <property type="entry name" value="Ribosomal_uS7_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036823">
        <property type="entry name" value="Ribosomal_uS7_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11205">
        <property type="entry name" value="RIBOSOMAL PROTEIN S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00177">
        <property type="entry name" value="Ribosomal_S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47973">
        <property type="entry name" value="Ribosomal protein S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00052">
        <property type="entry name" value="RIBOSOMAL_S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Small ribosomal subunit protein uS7" evidence="5">
        <location>
            <begin position="55"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAG5101185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="214" mass="24553" checksum="53605B1F69285917" modified="2022-05-25" version="1">MINILSLGSVKSYSVFPPSYVKPIFKKDQQALLQETGEADRLAHVPIKPAFHDETCSEFHDPIARKFTNFIMRKGKKALARSLLEQCFETIKRTQLAHYHKSKPEERGQIILDPLVILHKAIENVTPVMELLGIKKGGNTYQVPVPVTENRRRFLAMSWLVKSCKEKEARTPYAEVLAQELINASNNTGRVVKKKQDLHKQCEANRAYAHFRWT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HIH2</accession>
    <name>A0A8J2HIH2_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">3-oxoacid CoA-transferase</fullName>
            <ecNumber evidence="5">2.8.3.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">3-oxoacid CoA-transferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HICCMSTLAB_LOCUS10861</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Ketone metabolism; succinyl-CoA degradation; acetoacetyl-CoA from succinyl-CoA: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the 3-oxoacid CoA-transferase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the GIPC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.8.3.5" evidence="5"/>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5102130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1933379at2759"/>
    <dbReference type="UniPathway" id="UPA00929">
        <property type="reaction ID" value="UER00894"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008260">
        <property type="term" value="F:succinyl-CoA:3-oxo-acid CoA-transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd06707">
        <property type="entry name" value="PDZ_GIPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.42.10:FF:000097">
        <property type="entry name" value="PDZ domain-containing protein GIPC1 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1080.10:FF:000001">
        <property type="entry name" value="Succinyl-coa:3-ketoacid-coenzyme a transferase subunit b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1080.10:FF:000002">
        <property type="entry name" value="Succinyl-CoA:3-ketoacid-coenzyme A transferase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1080.10">
        <property type="entry name" value="Glutaconate Coenzyme A-transferase"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012792">
        <property type="entry name" value="3-oxoacid_CoA-transf_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012791">
        <property type="entry name" value="3-oxoacid_CoA-transf_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004165">
        <property type="entry name" value="CoA_trans_fam_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004164">
        <property type="entry name" value="CoA_transf_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004163">
        <property type="entry name" value="CoA_transf_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055349">
        <property type="entry name" value="GH2_GIPC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056814">
        <property type="entry name" value="GIPC1-3_GH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02429">
        <property type="entry name" value="pcaI_scoA_fam"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02428">
        <property type="entry name" value="pcaJ_scoB_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13707">
        <property type="entry name" value="KETOACID-COENZYME A TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13707:SF23">
        <property type="entry name" value="SUCCINYL-COA:3-KETOACID-COENZYME A TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01144">
        <property type="entry name" value="CoA_trans"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25083">
        <property type="entry name" value="GIPC1_GH1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25082">
        <property type="entry name" value="GIPC1_GH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00882">
        <property type="entry name" value="CoA_trans"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01273">
        <property type="entry name" value="COA_TRANSF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01274">
        <property type="entry name" value="COA_TRANSF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="PDZ" evidence="12">
        <location>
            <begin position="188"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="13"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="50"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00054372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00075112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAG5102130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="1438" mass="156835" checksum="F28401C0449A96A8" modified="2022-05-25" version="1">MFRKMPLFKPRTVSKSPVAQEKTTGNGAHNHEGHKTVSSSSSNNNINGTGKRDKFGHQDQTESTDDNQNSSKTHLVFRCQLAHGSPTGFISDFKNVRELYQKIAECYDLPTSESCMYGNTSSLSASFITIIECRKHWSWFMTLPAFRISHWILFCTLNTHKVDMNELLGGQIGLDDFIFAHRKSRPKEIELVKTEDALGLTITDNGAGYAFIKRIKEGSVIDKIKVIQVGDHIERINSENLVGRRHYEVAKILKEIPKGSTFTLRLIEPQKSGFGSIGPRGDIKKNKKSGFGSGKETLRFKADGSTQIQQVDDSSTIGVEKINNILENFMGINDNELATQIWELAEGKSNSMDFAEAIDNSDLEAFGIIKCHKIFFKIGVGCRQTRNKLQINKICAVNFSIKNDTPDETETDATDLKAPVGDGKLFKSVDHAISDIPDGAKLLVGGFGLCGIPENLIAAISKKGCKNLTVVSNNAGVDDFGLGILLSQQRIKRMIASYVGENAEFEKQYLSGNLEVELTPQGTLAERIRAGGAGIPAFFTATGLGTIIQEGNVVIKYSAEGKPEISGEPREVQEFNGRSYVMETAITGDFALIKAWKADKAGNLIFKKSARNFNPVMCKAAKVTIVEAEEILEVGQLDPDQIHVPGIYVDRILKGRNYEKRIEKLKTNASLKSKKATPATKARDKIIQRAALEFKDGMYVNLGIGMPMLAANYIKKGMNVTLQSENGILGLGPYPDESQVDPDLINAGKESVTVAPGASFFSSDESFAMIRGGHVDLTILGGMQVSKNGDLANWMIPGSMVKGMGGAMDLVSAAGTKVVVTMEHKARDGSPKILEACTLPVTGQQCVDLIITDLAVFEVIDGGLRLIELAPNVDISEVVSSTGCEFSVSDDLKIDLFYYYLLIVNFTMFSYIIKFGRANYKYPQSCLQINKILAVNYSLKNNTPDFENDKSELKIPREHKKCIMSADSAVHDIPNGAKLLIGGLGLGGWPLNAIDAIIKKGCKDLTVTSVTPGVGDIGLQKLLIQRQIKRLVTSFIGINPEFAKEYSKGNLELELIPQGTLAESIRAGGAGIPAFFTLTGCGTLIQDGNVVIKYDKDGKPEILSKPKHVQQFDGKNYLMEPAITGDFAIIKAWKADKAGNLIFRKLARNFNSIMCKAAKVTIVEAEEIVETGELDPDSIHVPGIYVDRIFKASHNDKFTKIIKTLSKLTVSPVSKKKERIIRRTALEFKDGRYINLGIGIPMLAAKYINNDTEAFLQFDTGALNFHYSQDTDRVDPDSMGHGVAPVTVLPGTSFFGCDESAAMIRGGHLDLTILGGAQVSKNGDLANWMIPGSMIVGMGGAMDLISSPKIKVIVTMEHKASDGSPKILDKCTIPLTGENCVDMIITELAVFEIVRGEGVTLIELAPNVDVTEVIEATGCEFSVSDDLKIMGQIDDNPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HIL3</accession>
    <name>A0A8J2HIL3_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Similar to Dscam2: Down syndrome cell adhesion molecule-like protein Dscam2 (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS9597</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5100524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HIL3"/>
    <dbReference type="OrthoDB" id="5969272at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5100524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="110" mass="12340" checksum="0E2BF2909FE1796B" modified="2022-05-25" version="1">MEVVVREITPPLLKASHGKFHLLPTGELLIHSLEFSDQFLSYRCRTMHRLTRQVVVSSSANVRISDHRGVLPPIILEHSGVIYISQDESTSMVCVAKACPSADYSQKTYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HIY7</accession>
    <name>A0A8J2HIY7_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS8707</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5097437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HIY7"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5097437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="104" mass="11813" checksum="41661AABEB644A20" modified="2022-05-25" version="1">MSDSIVNNDPDHSIVILGRVTNKNSDLFGFNEQVKNYLLLKYSEAGVYWCSSESGKEEQISVKDSPMAVINYLAKLNYHIAFISGSPINNNYYMWTLIKKGENK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HJL4</accession>
    <name>A0A8J2HJL4_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Similar to marchf3: E3 ubiquitin-protein ligase MARCHF3 (Xenopus laevis)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HICCMSTLAB_LOCUS10100</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5101027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HJL4"/>
    <dbReference type="OrthoDB" id="273089at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011016">
        <property type="entry name" value="Znf_RING-CH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46065">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE MARCH 2/3 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46065:SF3">
        <property type="entry name" value="FI20425P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12906">
        <property type="entry name" value="RINGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00744">
        <property type="entry name" value="RINGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51292">
        <property type="entry name" value="ZF_RING_CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="136"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="173"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="domain" description="RING-CH-type" evidence="12">
        <location>
            <begin position="47"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="225"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="26"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAG5101027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="286" mass="32334" checksum="118D4B3FC9AE989C" modified="2022-05-25" version="1" fragment="single">IPEGEGFSHHRAPASTEDLSPQVRGSQSSSSPNDSSAQVERCLSPSLISVGSCVCRICHRPSGITEKLVSPCRCKGTLAYVHLSCLERWLNQSCRNHCELCRYRFNAVETPRYHWKESLRIWMRHPRNLHHLKSDLAVVTLLTIVTTGLVVVCLLGMRYFIIEGRKIGISRLWTRGAIVFFITVVILGYCTTVYLLVKDQLAPWHRWWKNTVNIRLVIEPQQQQQQQHQHQRTSQESRVVGQLGEETADRTSAPTPDESTIAIDGIQVVDVKAKKAPAFKVPVSSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HJS6</accession>
    <name>A0A8J2HJS6_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Similar to EEED8.10: Putative RNA-binding protein EEED8.10 (Caenorhabditis elegans)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HICCMSTLAB_LOCUS9370</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5100072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HJS6"/>
    <dbReference type="OrthoDB" id="549243at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031146">
        <property type="term" value="P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057207">
        <property type="entry name" value="FBXL15_LRR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006553">
        <property type="entry name" value="Leu-rich_rpt_Cys-con_subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13318:SF95">
        <property type="entry name" value="F-BOX PROTEIN YLR352W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13318">
        <property type="entry name" value="PARTNER OF PAIRED, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25372">
        <property type="entry name" value="DUF7885"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00646">
        <property type="entry name" value="F-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00367">
        <property type="entry name" value="LRR_CC"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="F-box" evidence="3">
        <location>
            <begin position="82"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="48"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG5100072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="514" mass="57367" checksum="77EC6DCF45F01B6A" modified="2022-05-25" version="1">MRAELTAMTKRVVNELKRTDEARQASHRMELKLHSRILRVTAADSWHQPDSIEKQKKFPNKHTKSDPETVVKAPTPEPDNSDSVISKLNDDCLSEIFLYLPIADRIRVERVCKRWQALSHQSWHAVKSLNLSKNSWGLSPKIRVQVVDTSTLRKVLIRCGKFLTHLDLSQISHLLGSSTLTIVGKLCPNLQSVNITSIPLSQSGINSLMTHCQNITKFMMKTLRGPSERDLSLFFGVNKKLKYLSVEGDEYIVGKSFASLPQEVLEDLHLTRCTALVSSHFDVTINHLTNLKSLTLNMCVCLTDSTLEAVGNKTTITDLKFMGTHPLISANSLNNLKNLVNLERLCLKENVAVNDDFLINLSQNCKQLNYLDLTNCQAVTDRGISPLTTLNKLETLIVNFVSQVTDEAIANLQSLKVFSSWGCKGITDSGIINLINTAPNLISLDLSATSITSESLQVAVTVTRKRKSNYILKMIIGGTNAHSLDIKEISPLLQIVNLDFSVLENTTSKYEYLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HK57</accession>
    <name>A0A8J2HK57_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Odorant binding protein 1.54</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HICCMSTLAB_LOCUS10035</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PBP/GOBP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5100962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HK57"/>
    <dbReference type="OrthoDB" id="7665616at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005549">
        <property type="term" value="F:odorant binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007608">
        <property type="term" value="P:sensory perception of smell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23992">
        <property type="entry name" value="PBP_GOBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.20">
        <property type="entry name" value="Pheromone/general odorant binding protein domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006170">
        <property type="entry name" value="PBP/GOBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036728">
        <property type="entry name" value="PBP_GOBP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11857:SF43">
        <property type="entry name" value="GEO07291P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11857">
        <property type="entry name" value="ODORANT BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01395">
        <property type="entry name" value="PBP_GOBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00708">
        <property type="entry name" value="PhBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47565">
        <property type="entry name" value="Insect pheromone/odorant-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035169503" evidence="5">
        <location>
            <begin position="25"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAG5100962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="137" mass="15502" checksum="79C09B1C0CE5A80C" modified="2022-05-25" version="1">MKVFASIFALGFIGILGNIADSNSENSEYLKQCMAESGVDQTSVDKLQGREWEMNNKKLQCYSKCLMIKKGVINDDGTLNEENMKKDMTREFPDGKIDEVMMKCKDPKGADACENSLLILKCFLDYTIFAMQKDKDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HKH9</accession>
    <name>A0A8J2HKH9_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">G/T mismatch-specific thymine DNA glycosylase</fullName>
            <ecNumber evidence="15">3.2.2.29</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Thymine-DNA glycosylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">HICCMSTLAB_LOCUS9947</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>Hydrolyzes mismatched double-stranded DNA and polynucleotides, releasing free thymine.</text>
            <dbReference type="EC" id="3.2.2.29"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="14">Homodimer. Interacts with AICDA and GADD45A.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the uracil-DNA glycosylase (UDG) superfamily. TDG/mug family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.29" evidence="15"/>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5100874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HKH9"/>
    <dbReference type="OrthoDB" id="565731at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141016">
        <property type="term" value="F:G/T mismatch-specific thymine-DNA glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032183">
        <property type="term" value="F:SUMO binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004844">
        <property type="term" value="F:uracil DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006285">
        <property type="term" value="P:base-excision repair, AP site formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040029">
        <property type="term" value="P:epigenetic regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd10028">
        <property type="entry name" value="UDG-F2_TDG_MUG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.470.10:FF:000002">
        <property type="entry name" value="G/T mismatch-specific thymine DNA glycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.470.10">
        <property type="entry name" value="Uracil-DNA glycosylase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017956">
        <property type="entry name" value="AT_hook_DNA-bd_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015637">
        <property type="entry name" value="MUG/TDG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005122">
        <property type="entry name" value="Uracil-DNA_glycosylase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036895">
        <property type="entry name" value="Uracil-DNA_glycosylase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12159">
        <property type="entry name" value="G/T AND G/U MISMATCH-SPECIFIC DNA GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12159:SF9">
        <property type="entry name" value="G_T MISMATCH-SPECIFIC THYMINE DNA GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03167">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00384">
        <property type="entry name" value="AT_hook"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00986">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00987">
        <property type="entry name" value="UreE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52141">
        <property type="entry name" value="Uracil-DNA glycosylase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0010">Activator</keyword>
    <keyword evidence="6" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="Uracil-DNA glycosylase-like" evidence="19">
        <location>
            <begin position="281"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="38"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="126"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="216"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="470"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="650"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="701"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="852"/>
            <end position="941"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1072"/>
            <end position="1112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="85"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="147"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="18">
        <location>
            <begin position="186"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="18">
        <location>
            <begin position="227"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="470"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="490"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="18">
        <location>
            <begin position="509"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="18">
        <location>
            <begin position="542"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="18">
        <location>
            <begin position="560"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="575"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="586"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="701"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="723"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="753"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="802"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="929"/>
            <end position="941"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="1082"/>
            <end position="1095"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00052915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00061261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00064519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00066769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00071248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00083221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="SMART" id="SM00986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="CAG5100874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="1112" mass="123163" checksum="7BEEC58D0B39A58F" modified="2022-05-25" version="1">MIFFHSDCRSYPSPVQNGVQNNSTMNCSGSQGLMVKQEARDDGYETSPDLEMRSNGGDSSQQYHTPLTPHTPHTPHTPHTPLTPISATSHQPQQPSSTGATLGQVPMKCETPVDPYSFVDEEMSMSGGIRTASSPGENIDGLTCSTSSNIQSSIGTPSSSSPSPMPSQQQQQQQQHLLQQQQQQQLHHHQQQHHHQQQQQHQLELEQQHHMSMMMNGGLNSMQLPHQPKKRGRKKKSEMILTPEEAELAEAKKRAKTYKERKKHDRFDGMPEEEVSKRVLPDHLTDNLDIIIIGINPGLFAAYKGHHYAGPGNHFWKCLHLSGLTPDPLTAEDDYTLLRLGIGFTNMVARATKGSADLTRKEIKEGSSLLLEKLKRYKPKIAVFNGKLIYEVFSGKKEFGFGRQPNLIEGTNTYMWVMPSSSARCAQLPRAADKVPYYAALKKFRDYLNGTISHLEESDIVFADPKINKKKDSDATEDKKSVYEGEDIDGESRMSELSEIKPEQGLIPGKKKRGRPKKIKNPDDQMMIPSESDPKMDTTNPGSGGNVEGSNIGSGGEVIKKRRGRPKKIHQQQKQQEREAREREQMVQQHQQHQQQQQQHHLHHPHHPQNMGHLGDNYGNVPGCFSPPLMSPPKPFAHMAPYPQPDSNFFSQGMNDSPYNMSAKQSPVHLQQHYSQSPKSMSLSFTHSDLSSEINTAISSENNLEPSPLTSPSVEHPDFEPPTSMSQQQNLTNDHRAYNPAGTTDGTIPHSGSPGTQSHSSYTSYMGFHDQPTPDSHGHGHQTTPTGLNPGEDQQHSHQSHHTPPLSHPHTPTHSSMSPHPHEQYVMKRNTGQDVASKSLSDLESLVDQIPSIADGGNQRLHSHPGIPDDGLGDNKLEPHHQSYLSGFSGPGMNNYSPPLGGGIYPGSQPLYPGENYGSPYGMNGRLDQQQQQQQQQHQHQQQQQQQQQQQQQQQQQQQQQQQQQQHSKSYTVENLASSNYTPSMSQAGNSYSNIIPGPHYPVPTMGPTNGYLFGGLESSLMQRTYGMGGMTGMGGMHPSLGHMANPYPYNTSYSSSFEAYPTPPAGIHAPSPNYPGGYGVSSTTSSPGNSTPPSYLQSHHRPPVDLGYDGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HM17</accession>
    <name>A0A8J2HM17_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="21">Similar to ACAC: Acetyl-CoA carboxylase (Gallus gallus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">HICCMSTLAB_LOCUS11396</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>N(6)-biotinyl-L-lysyl-[protein] + hydrogencarbonate + ATP = N(6)-carboxybiotinyl-L-lysyl-[protein] + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13501"/>
            <dbReference type="Rhea" id="RHEA-COMP:10505"/>
            <dbReference type="Rhea" id="RHEA-COMP:10506"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83144"/>
            <dbReference type="ChEBI" id="CHEBI:83145"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.14"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>hydrogencarbonate + acetyl-CoA + ATP = malonyl-CoA + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11308"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.4.1.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>biotin</name>
            <dbReference type="ChEBI" id="CHEBI:57586"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; malonyl-CoA biosynthesis; malonyl-CoA from acetyl-CoA: step 1/1.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5103211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="14612at2759"/>
    <dbReference type="UniPathway" id="UPA00655">
        <property type="reaction ID" value="UER00711"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003989">
        <property type="term" value="F:acetyl-CoA carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004075">
        <property type="term" value="F:biotin carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001295">
        <property type="term" value="P:malonyl-CoA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd06850">
        <property type="entry name" value="biotinyl_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.460.10:FF:000001">
        <property type="entry name" value="Acetyl-CoA carboxylase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.100:FF:000005">
        <property type="entry name" value="Acetyl-CoA carboxylase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000005">
        <property type="entry name" value="Acetyl-CoA carboxylase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1770.10:FF:000001">
        <property type="entry name" value="acetyl-CoA carboxylase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.20:FF:000003">
        <property type="entry name" value="acetyl-CoA carboxylase isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.20:FF:000005">
        <property type="entry name" value="acetyl-CoA carboxylase isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.226.10:FF:000010">
        <property type="entry name" value="acetyl-CoA carboxylase isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="entry name" value="ATP-grasp fold, A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.460.10">
        <property type="entry name" value="Biotin dependent carboxylase carboxyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1770.10">
        <property type="entry name" value="PreATP-grasp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049076">
        <property type="entry name" value="ACCA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049074">
        <property type="entry name" value="ACCA_BT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034733">
        <property type="entry name" value="AcCoA_carboxyl_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013537">
        <property type="entry name" value="AcCoA_COase_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005481">
        <property type="entry name" value="BC-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001882">
        <property type="entry name" value="Biotin_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011764">
        <property type="entry name" value="Biotin_carboxylation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005482">
        <property type="entry name" value="Biotin_COase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011763">
        <property type="entry name" value="COA_CT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011762">
        <property type="entry name" value="COA_CT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005479">
        <property type="entry name" value="CPAse_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45728:SF3">
        <property type="entry name" value="ACETYL-COA CARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45728">
        <property type="entry name" value="ACETYL-COA CARBOXYLASE, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08326">
        <property type="entry name" value="ACC_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21385">
        <property type="entry name" value="ACCA_BT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02785">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00289">
        <property type="entry name" value="Biotin_carb_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01039">
        <property type="entry name" value="Carboxyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02786">
        <property type="entry name" value="CPSase_L_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00878">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="PreATP-grasp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="Rudiment single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="Single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50979">
        <property type="entry name" value="BC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00188">
        <property type="entry name" value="BIOTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50989">
        <property type="entry name" value="COA_CT_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50980">
        <property type="entry name" value="COA_CT_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00866">
        <property type="entry name" value="CPSASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00867">
        <property type="entry name" value="CPSASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0092">Biotin</keyword>
    <keyword evidence="9" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="5 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="23"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="52"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="domain" description="Biotin carboxylation" evidence="18">
        <location>
            <begin position="270"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-grasp" evidence="17">
        <location>
            <begin position="423"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="domain" description="Lipoyl-binding" evidence="16">
        <location>
            <begin position="893"/>
            <end position="967"/>
        </location>
    </feature>
    <feature type="domain" description="CoA carboxyltransferase N-terminal" evidence="19">
        <location>
            <begin position="1705"/>
            <end position="2043"/>
        </location>
    </feature>
    <feature type="domain" description="CoA carboxyltransferase C-terminal" evidence="20">
        <location>
            <begin position="2047"/>
            <end position="2362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="CAG5103211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="2482" mass="279839" checksum="6A407E4FA2C2B01B" modified="2022-05-25" version="1">MSGDEQKTNPNLHQERGIQQQRFLACCLVIAIAVVWSFQFIVQFSYDVKQTLGLTSVTLLLLYLSSFVFFKNRKKYSNKHIELGKTDNESQALHLVSVTEQENFQKEFNKINKMAETPVSFVVGGSDQLEELELETEDSFPIEGFDGYQQPPAMPSINEQRRRLRRIKRFVLAQSNATDITWKSSDNFYAESGNYNVEKHNHRRASEDCDASVLISNESVKSKSSMSSTSLQPSMSQGTVMIMTQNRLQEKDFTVATPEEFVHRFGGTKVINKVLIANNGIAAVKCMRSIRRWSYEMFKNERAIRFVVMVTPEDLKANAEYIKMADQYVPVPGGTNNNNYANVELIVDIAIRTQVQAVWAGWGHASENPKLPELLHKKDISFIGPSERAMWALGDKIASSIVAQTADVPTLPWSGSGLKAQYSGKKIKISSELFKKGCVSTIEECLAAANKIGFPVMVKASEGGGGKGIRKVENAEELPTLFRQVQTEVPGSPIFIMKLAKCARHLEVQLLADIYGNAISLFGRDCSIQRRHQKIIEEAPAVIAKPEIFEEMEKAAVRLAKMVGYVSAGTVEYLYDTSGSYYFLELNPRLQVEHPCTEMVSDVNLPAAQLQIAMGLHLHHIKDIRLLYGESPWGDSAIDFDQPRHKPQPWGHVIAARITSENPDEGFKPSSGTVQELNFRSSKNVWGYFSVGVSGGLHEFADSQFGHCFSWGEDRNQARENLVIALKELSIRGDFRTTVEYLITLLETECFLTNNIDTAWLDALIAERVRSDKPDVLLAVTCGALHIADRTITAAFSGFQTSLERGQIQAGNDLNNIIDVELINDGIKYKIQTAKSGPNSYFLVMNNSHKDVEVHRLSDGGILLSFDGASFTTYMREEVDRYRIVIGNQTCVFEKDNDPSLLRSPSAGKLISFLVEDGGHVEPGQAYAEIEVMKMVMTVTAGEAGSVFYVKRPGAVLEAGVLIAHLELDDPSLVTKAQDYTGQFPAPIIPAIPEKLNLLHCKYRASLENTLAGYCLPDPYHLPRQRELIEKFMNSLRDPSLPLLELQEVISTISGRIPISVEKKIRKLMTLYERNITSVLAQFPSQQIAAVIDSHAATLSKRSDRDVFFLTTQAIVQLVQRYRNGIRGRMKTAMHELLRQYYTVESQFQQGHYDKCVSALIQQYKDNMSMVTNTIFSHNQVSKKNVLVTMLIDHLWANEPGLTDELASTLTELTSLNRAEHCRVALRARQVLIAAHQPAYELRHNQMESIFLSAVDMYGHDFHPENLQKLILSETSIFDILHDFFYHTNRAVCNAALEVYVRRAYISYEFTCLQHLELSGEIPLVYFQFLLPSNHPNRQNQLLINHRTGAVAAFQDLDHFSQYADEVLDLLQDLSSPNSVSAKVLEAVDAAGSESRHSTSINVSFSTTEAGGPVEIGEKSAEPVHILSITVQDNGNQDDAAMARLFGDWCASNKEELVSRGIRRVTFAALQKRQFPKFFTYRNRDGFVEDRIYRHLEPGCAFQLELNRMRTYELEALPTSNQKMHLYLGKAKVAKGQQVTDYRFFIRSIIRHSDLITKEASFDYLHNEGERVLLEAMDELEVAFSHPLAKRTDCNHIFLNFVPTVIMDPARIEESVTSMVLRYGPRLWKLRVRQAEIKMTIRPAPGKPTSTVRLCISNDSGYSIDLHLYTETTEAKTGIIRLESYSPINSNRRPGPMHGMPVSTPYLTKDYLQAKRFQAQSSGTTYVYDLPDMFRQELEKAWAKYIEERPNIENLSIPSPVIDCIELVLDGENLVEQKRLPGENDVGMVAWKLTLFTPEFPLGREIILIANDLTHLIGSFGPKEDLVFYRASERARQLGIPRVYFSANSGARIGLAEEVKALFKIAWEDDAVPEKGFKYIYLTPDDYARLSPLNSVKASLIEDGGEARYKITDIIGKDDGLGVENLKYAGLIAGETSRAYDEIVTISIASCRAIGIGSYLVRLGQRVIQIENSHIILTGYRALNAVLGREVYASNNQLGGIQIMYHNGISHVTEPRDLDGIATVLKWISFVPKNKGGALPIITPADPVDREIGYVPTRTPYDPRWMLDGRKSTVDPTMWESGFFDFGSWAEIMRPWAQTVVTGRARLGGIPCGIVAVETRTMEIHLPADPANLDSEAKTVSQAGQVWYPDSAFKTAQAIKDFNREELPLFIFANWRGFSGGMKDMYEQIMKFGAYIVDGLKEYKKPVFIYIPPNGELRGGAWAVVDPTINPRFMEMFADNTSRGGVLEPEGIVEIKFKTKDILKTIHRLDPVVHNLKEKLSHPLTAEERAKVEIEIHSREQILEPMYRQAAVHFSDLHDTPERMLEKNAINDIIPWRKARTLLYWRLRRRLLEEEFRSDILSTQPSLDVRQVDAMLRRWFVEDKGTTESYLLDQDESVVEWLQSQRDDEDSVVMHNINCVKRGAVVTHIKDSLEKCPDVRLEAVLEIAHRLTSAERAELQRTLAQLEASTVQEHHNDSSASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HM55</accession>
    <name>A0A8J2HM55_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Similar to SAV1: Protein salvador homolog 1 (Homo sapiens)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HICCMSTLAB_LOCUS12455</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5106828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HM55"/>
    <dbReference type="OrthoDB" id="5339429at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060090">
        <property type="term" value="F:molecular adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035329">
        <property type="term" value="P:hippo signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008285">
        <property type="term" value="P:negative regulation of cell population proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043065">
        <property type="term" value="P:positive regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21433">
        <property type="entry name" value="SARAH_Sav"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.70.10:FF:000035">
        <property type="entry name" value="Salvador homolog 1 (Drosophila)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011524">
        <property type="entry name" value="SARAH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030030">
        <property type="entry name" value="Sav"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47522:SF2">
        <property type="entry name" value="PROTEIN SALVADOR HOMOLOG 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47522">
        <property type="entry name" value="SALVADOR FAMILY WW DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00397">
        <property type="entry name" value="WW"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50951">
        <property type="entry name" value="SARAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="WW" evidence="4">
        <location>
            <begin position="196"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="WW" evidence="4">
        <location>
            <begin position="231"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="SARAH" evidence="5">
        <location>
            <begin position="317"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="177"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAG5106828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="386" mass="44420" checksum="B8B510CA0701D9DF" modified="2022-05-25" version="1">MLSRKNKDLRTIKEGVVGKYVKKETPPEMPIINVWTTEPNRRNRRQHNQPAIPAAMPVPQQPSMVQKFGNTKTTTSAVGLGSHEGKYTPNSSVPDLAQRFASLSVNPGVIEGAVSRTATPLYHPRLSPTISSSHTYVNQYAGSEYHLDRVQTPQLPYIPFESDVAYDDFNKAYHNPGYSRAHSERSSSRNEQPAELPLPPGWSVDFTLRGRKYYIDHNTKTTHWSHPLEKEGLPTGWERIESPEYGVYYVNHITRQAQYEHPCYPTELQQQVGIVSPPRHTHFHSHSVLVPANPYLNEEIPHWLYVYSRASITLDRKLRWELFRLPELDCFNAMLTRLYKQELEEVVMRYEEYRSALLCEMEQRLKELNPENESSAGAVALRRSLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HMG6</accession>
    <name>A0A8J2HMG6_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Eukaryotic translation initiation factor 4H</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">HICCMSTLAB_LOCUS11383</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Stimulates the RNA helicase activity of EIF4A in the translation initiation complex. Binds weakly mRNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Perinuclear region</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5103185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HMG6"/>
    <dbReference type="OrthoDB" id="48651at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12401">
        <property type="entry name" value="RRM_eIF4H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000414">
        <property type="entry name" value="Eukaryotic translation initiation factor 4H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034229">
        <property type="entry name" value="eIF4H_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23236">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4B/4H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23236:SF11">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0007">Acetylation</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 14" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3" id="KW-0488">Methylation</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="13">
        <location>
            <begin position="32"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="110"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="110"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="12">
        <location>
            <begin position="124"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="12">
        <location>
            <begin position="146"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="171"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="215"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="267"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00025462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CAG5103185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="278" mass="29656" checksum="9E55A36EC5730E88" modified="2022-05-25" version="1">MAGCGDHEDSRDYLGGGSRGGSRKPLPTEPPYTAYVGNLPDGIIQRDIDRIFEQQRVKNVRLVKDRETDRFKGFCYVEFEDLRDLEDALELNGRVKVESNIVKIDVAEGKRNDRGGGFDRRRGGGNSAGSGGGGFGYNDRRPQGNSGPGSRQGPGGYGTDARGNRGNYGNFHEDGPGRDWSSRGGIGGGSSSGGPPRSNYGAASGPRRGGMSGNDRSKSFQDDPYLKGPPPDTTGRKKLVLQKRSVPDPVNALAESSKGSSIYGGAKPRDEKVEASEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HMQ0</accession>
    <name>A0A8J2HMQ0_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Similar to Enteropeptidase-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">HICCMSTLAB_LOCUS10477</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5101575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6411962at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00112">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000003">
        <property type="entry name" value="Transmembrane serine protease 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.400.10">
        <property type="entry name" value="Low-density Lipoprotein Receptor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036055">
        <property type="entry name" value="LDL_receptor-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023415">
        <property type="entry name" value="LDLR_class-A_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002172">
        <property type="entry name" value="LDrepeatLR_classA_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000082">
        <property type="entry name" value="SEA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036364">
        <property type="entry name" value="SEA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033116">
        <property type="entry name" value="TRYPSIN_SER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24252">
        <property type="entry name" value="ACROSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24252:SF7">
        <property type="entry name" value="HYALIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00057">
        <property type="entry name" value="Ldl_recept_a"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01390">
        <property type="entry name" value="SEA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00192">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57424">
        <property type="entry name" value="LDL receptor-like module"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82671">
        <property type="entry name" value="SEA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01209">
        <property type="entry name" value="LDLRA_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50068">
        <property type="entry name" value="LDLRA_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50024">
        <property type="entry name" value="SEA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00135">
        <property type="entry name" value="TRYPSIN_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9 10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 11" id="KW-0645">Protease</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0720">Serine protease</keyword>
    <keyword evidence="6" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="29"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="domain" description="SEA" evidence="14">
        <location>
            <begin position="65"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="15">
        <location>
            <begin position="1293"/>
            <end position="1529"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="293"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="776"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="300"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="792"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="937"/>
            <end position="955"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="949"/>
            <end position="964"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="1018"/>
            <end position="1033"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="1545"/>
            <end position="1563"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="1557"/>
            <end position="1572"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="16">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU363034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CAG5101575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="1576" mass="176817" checksum="8B16764DBA494EC4" modified="2022-05-25" version="1" fragment="single">NDYYLPPRSAWSRVPPHPSKTHGNARWKVGSAVLIIAALLVIIVVVAIAGLALWMGAMRSDSTNAVLVFSCSIRINRGEKYNPMLKLNTSMVFREKERKYKNIFDALFKRSVLGPSFKQAIIDRFENGTLKVFFRLYLDRRKIPRSITNVEETVQDIIAQETYSSSSLFNDMELDLTNIIVRRLTDVSPRTQKPLVSQRNAMITKNGLLRPSRNNTLLINTKSKPNLNSKPAKMEPSEADIDFANIPTIQGTYQATKINPVATKTTTEVSSQIQKTETKIESGVIEIKKETKVGKETTTEEITSSVSWKEESTTSTSSTTSPTTTTTTTKKPFNSFPQPDFEESPWRPIIPSYSQESKLKDSGVKTESSIEIEKISLTTPVPAIKFNLPAVALSPVDMQDTDFPHDRIVPQEMVNFRPNGKFKNKIPGVEELEKPEIEVSGQLPPETFNLHVGTSGTQNFKPVDSKHPVIETEEPILLTSEFSEISGVGIAEPVSELDLELDLESRNKFSDIAALPERVQEKDEKQPIYTSYKTPNLNGESNPSLVEHSGTLKPFRHTIPVDKINLNPEKVQIEENKDEKIINESNYSAKYEDFSVTEVDFIPSDSTDRIDDDKVMTLSTTEIDAELLHTNFDTEKLDLQQATVASEVLETTEGQTQAPELFIWTWNNETKPEVEQKKTYNETLKANIVRDENRDANPRVTNATESQKSLMDEGSIRSSELLEKLFSTKDLESKPSNVEEHRPIQSIVEVVTSISTKVSTKVRTNNVVLSFDITNSTSPPIIHNDEEENGKNSEGANSENRSFSDQISPSDLETFDLKTLQSFDRKISTQEKEAILEKLKKLAEVRTDSDSVKGKNSTRVTKFPEIDKNHKNFVDVEELKKFADIAMGNKTIAGNFSSQVTLSRDGIEVHKKVLNKVVKDEEEVVKENSESCKGFKCPDGKCLPAAGRCNMLGECANSEDEANCTCADFLRSQLLHQKICDGIPDCWDYSDESQCDWCSVGQFVCGNSRFCIDVVKVCDGYKDCPGGEDEKKCAALIDDDDDDDFREDKSVLKKISNWEERKEKINSTFQLEDQKAVETVATTFRIETLKEEIQKSVLNTGMFDGNFDGRQTRVGENTKVFGREIAVDAKTKNVIDNDQKGFSTKVSIPVNKKPDDFFNNDYSYIKNNLGTEINSYSDRGYLSVRKNGKWGKLCLNSTDGLLDDKRTIWTIEDLGRAVCKAITYQDYEKVEKVIEKRKGRNQIYYSLFFNDKLPDKTSLTFKTSDCPSGEVLKVKCKSLECGIRTQTTSQARIVGGGSSEAGSWPWQVALYKEGDYQCGGALISDKWVLSAAHCFYNAKNEYWVARIGATRRGNFPSPHEQILTLDFINLHPEYIDSGFINDVALLRLERPVIFSDYVRPVCLPDSEPKSGTICTVTGWGQLFEIGRIFPDTLQEVELPLISTEECRKKTLFLPLYRITSGMLCAGLKDGGRDACMGDSGGPLVCRDKTNDKYTLHGITSNGYGCARPGRPGVYTKTIHYLPWIERSMKQKDVRPLIPACKGHRCPLGECLPRSRVCNGFLECSDGSDERDCPSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HN14</accession>
    <name>A0A8J2HN14_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Similar to slc38a7: Putative sodium-coupled neutral amino acid transporter 7 (Danio rerio)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HICCMSTLAB_LOCUS12354</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5106627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HN14"/>
    <dbReference type="OrthoDB" id="438545at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF652">
        <property type="entry name" value="TRANSMEMBRANE AMINO ACID TRANSPORTER FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="36"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="65"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="110"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="154"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="180"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="255"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="295"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="322"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="360"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="6">
        <location>
            <begin position="33"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAG5106627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="410" mass="44863" checksum="3B65F395E6861B87" modified="2022-05-25" version="1">MRFLRRNGYSLIDNSVEVAFDNSSTRSNFNPEGTTVIGTIFLLLNATLGAGLLNFPLAFDRSGGVISAIIVQLSFLIFITIALVTLANCSDITKTSSMPDTVAGLCGPKTLILCGICVTIYSFGCCLTFIIVIGDQFERVLATYYGTDYCHHWFLSRTFITCVSCTLFILPISFFKRLDILSYVSSVGCITIVYVIWVIIHQSINTPDYPKPTQAWPRNASQAFQLVPIICFAYQTFGMGHVPSDILQGYSDKSASLAIAIIAIAVKNFTTYPIVLFCGRSSLMGLFHAEIEDNVAVRAFVTLLWFILTLFAAVVISDISPVINLMGTLSATFIFIFPGICLLQSVLVKDPAFRLYKSRFLIVVAVVMTALGGFVCGLVFVQALEDLYQVPVDKKFVTGVRIGLGGSLCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HND4</accession>
    <name>A0A8J2HND4_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DNA primase</fullName>
            <ecNumber evidence="9">2.7.7.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HICCMSTLAB_LOCUS12077</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the eukaryotic-type primase small subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.-" evidence="9"/>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5106060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HND4"/>
    <dbReference type="OrthoDB" id="19606at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005658">
        <property type="term" value="C:alpha DNA polymerase:primase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006269">
        <property type="term" value="P:DNA replication, synthesis of primer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04860">
        <property type="entry name" value="AE_Prim_S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.920.10">
        <property type="entry name" value="DNA primase, PRIM domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002755">
        <property type="entry name" value="DNA_primase_S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014052">
        <property type="entry name" value="DNA_primase_ssu_euk/arc"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00335">
        <property type="entry name" value="primase_sml"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10536">
        <property type="entry name" value="DNA PRIMASE SMALL SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01896">
        <property type="entry name" value="DNA_primase_S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56747">
        <property type="entry name" value="Prim-pol domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0235">DNA replication</keyword>
    <keyword evidence="2 9" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="3 9" id="KW-0639">Primosome</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 9" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAG5106060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="397" mass="46995" checksum="3B22EAF438C47711" modified="2022-05-25" version="1">MEDPVERKKIQQLKSYYQLVLPVTQILKWLSYADKFRICYREFSFVTVRSEFSRYESFNNAKEFRSRLINLGPARIDVGPTWPKSPLWSSKQGLDPVRKELVFDIDLTDYDDVRICCQEKNICVKCWKYMVIACKIIHRSLVEDWGYKHTLWVFSGRRGIHAWVCEPSVLKFDDDERYMISEFFQVSLTNSFGESQFRLTGITSFIQRALDIIDEDFLRFCVVEMDMLGTDERVQKFINLLRCPKIMRGVKKEFLDHDNSIDRWNAFLEYFYTKLVKGEIPEDCRYLVEELKLQYCYPRIDGSVTEGINHLLKMPFSVHPATDKISVPFDPEKIESFDPTTVPTLTQILSEVAEFKSCQQPGQRWNQWNPLYLYKTSLRDSFKVFIKFLVNLHGDLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HNH2</accession>
    <name>A0A8J2HNH2_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS11612</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5103643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HNH2"/>
    <dbReference type="OrthoDB" id="7700607at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5103643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="274" mass="30971" checksum="5430486C86B17E27" modified="2022-05-25" version="1">MTLKKEGEKKKTTKKTNKPKKSKVCPTIDETKNGTGDKNDTTAYSPESSADQNPPDAGERAGNSKLDRKPSLRRKLGAFIRGSADLPSVINRGFQPIRRSFSFNKDLHRVYENTHPQEYGRTRNAQWYNSLCSLAEVDSKDEGGHVATKKNGFDDDFEKRQVSRTHSFLDNSTVTRRRPKTSEQFTYGRHSDYYDSAIDLSKPPFEACSLPVLTHLTKEKDDVEVEPVQARESNRGWNGWGILRSSARNSLLRLNTFSSTTGFQEPSDYSIALQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HNS3</accession>
    <name>A0A8J2HNS3_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Large ribosomal subunit protein uL4m</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">39S ribosomal protein L4, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HICCMSTLAB_LOCUS13860</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the universal ribosomal protein uL4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5109224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HNS3"/>
    <dbReference type="OrthoDB" id="275876at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1370.10:FF:000005">
        <property type="entry name" value="39S ribosomal protein L4, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1370.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002136">
        <property type="entry name" value="Ribosomal_uL4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013005">
        <property type="entry name" value="Ribosomal_uL4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023574">
        <property type="entry name" value="Ribosomal_uL4_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03953">
        <property type="entry name" value="rplD_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10746">
        <property type="entry name" value="50S RIBOSOMAL PROTEIN L4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10746:SF6">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL4M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00573">
        <property type="entry name" value="Ribosomal_L4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52166">
        <property type="entry name" value="Ribosomal protein L4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="120"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00040565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00082711"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAG5109224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="294" mass="33611" checksum="F62C7ACDF59FE8C8" modified="2022-05-25" version="1">MSIILRNILTKLKKYPGQVSNFCSVVNTTDNVHEAEGKINIPTAPIISTINYNDEDQMYQQKREVWIDSLDTIEEKKLGLMTLHPAVFADKPRLDTLYENVRWQRMYRFVNYAHVKNRAERRGGGRKPWPQKGGGRARHGSINSPLFKGGGLAHGPRSPTVHFYMLPFFSRVNGLTAALSVKLAQDDLYVVNNLEIPSKDPKYIESLMEERNWGPSLLLVDTEDIMPENITIATDELKHVNLMPAYGLNVYSMLKHSTLVLTERAVRHVESKLLYQLYRPDTKALTSRFKLSQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HP06</accession>
    <name>A0A8J2HP06_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">5-demethoxyubiquinone hydroxylase, mitochondrial</fullName>
            <shortName evidence="8">DMQ hydroxylase</shortName>
            <ecNumber evidence="8">1.14.99.60</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Ubiquinone biosynthesis monooxygenase COQ7</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">coq7</name>
        <name evidence="9" type="ORF">HICCMSTLAB_LOCUS12620</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the hydroxylation of 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) during ubiquinone biosynthesis. Has also a structural role in the COQ enzyme complex, stabilizing other COQ polypeptides. Involved in lifespan determination in a ubiquinone-independent manner.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>a 5-methoxy-2-methyl-3-(all-trans-polyprenyl)benzene-1,4-diol + AH2 + O2 = a 3-demethylubiquinol + A + H2O</text>
            <dbReference type="Rhea" id="RHEA:50908"/>
            <dbReference type="Rhea" id="RHEA-COMP:10859"/>
            <dbReference type="Rhea" id="RHEA-COMP:10914"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:84167"/>
            <dbReference type="ChEBI" id="CHEBI:84422"/>
            <dbReference type="EC" id="1.14.99.60"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
        <text evidence="8">Binds 2 iron ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 8">Cofactor biosynthesis; ubiquinone biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of a multi-subunit COQ enzyme complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Mitochondrion inner membrane</location>
            <topology evidence="8">Peripheral membrane protein</topology>
            <orientation evidence="8">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the COQ7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.99.60" evidence="8"/>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5107180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HP06"/>
    <dbReference type="OrthoDB" id="275371at2759"/>
    <dbReference type="UniPathway" id="UPA00232"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031314">
        <property type="term" value="C:extrinsic component of mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008682">
        <property type="term" value="F:3-demethoxyubiquinol 3-hydroxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016709">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008340">
        <property type="term" value="P:determination of adult lifespan"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000377">
        <property type="term" value="P:regulation of reactive oxygen species metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006744">
        <property type="term" value="P:ubiquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01042">
        <property type="entry name" value="DMQH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01658">
        <property type="entry name" value="COQ7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011566">
        <property type="entry name" value="Ubq_synth_Coq7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11237:SF4">
        <property type="entry name" value="5-DEMETHOXYUBIQUINONE HYDROXYLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11237">
        <property type="entry name" value="COENZYME Q10 BIOSYNTHESIS PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03232">
        <property type="entry name" value="COQ7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="Ferritin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0408">Iron</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="6 8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0831">Ubiquinone biosynthesis</keyword>
    <feature type="binding site" evidence="8">
        <location>
            <position position="80"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="113"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="200"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="200"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="203"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAG5107180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="239" mass="26219" checksum="C76CFACE8377625A" modified="2022-05-25" version="1">MEQAQLKSGVAYAPCVVREWSPPIRSTEAQGYCVCGEAVEKMLHLGRGGVRFASSTAVATADTKAAKLLDSIIRVNHAGELGADRIYAGQMAVLGKSSVGPTIEHMWDQEKRHREKFEELIRKYRARPTALLPIWNVAGFILGAGTALMGEKAAMACTVAVETVIVEHYNDQLRALMEDKNQEDVDQELLETIKKFRDEEQEHHDTGIDLGAEQAPLYDALTKIIKAGCKTAIAISKVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HPK6</accession>
    <name>A0A8J2HPK6_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 12 16">6-phosphogluconate dehydrogenase, decarboxylating</fullName>
            <ecNumber evidence="5 12 16">1.1.1.44</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">HICCMSTLAB_LOCUS11915</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="1 12">Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11 12 16">
            <text>6-phospho-D-gluconate + NADP(+) = D-ribulose 5-phosphate + CO2 + NADPH</text>
            <dbReference type="Rhea" id="RHEA:10116"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:58759"/>
            <dbReference type="EC" id="1.1.1.44"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 12 16">Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 3/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 12">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 12 16">Belongs to the 6-phosphogluconate dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.44" evidence="5 12 16"/>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5104264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HPK6"/>
    <dbReference type="OrthoDB" id="434986at2759"/>
    <dbReference type="UniPathway" id="UPA00115">
        <property type="reaction ID" value="UER00410"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004616">
        <property type="term" value="F:phosphogluconate dehydrogenase (decarboxylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019521">
        <property type="term" value="P:D-gluconate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006098">
        <property type="term" value="P:pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1040.10:FF:000002">
        <property type="entry name" value="6-phosphogluconate dehydrogenase, decarboxylating"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.320:FF:000002">
        <property type="entry name" value="6-phosphogluconate dehydrogenase, decarboxylating"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000007">
        <property type="entry name" value="6-phosphogluconate dehydrogenase, decarboxylating"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.320">
        <property type="entry name" value="6-Phosphogluconate Dehydrogenase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006114">
        <property type="entry name" value="6PGDH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006113">
        <property type="entry name" value="6PGDH_Gnd/GntZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006115">
        <property type="entry name" value="6PGDH_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006183">
        <property type="entry name" value="Pgluconate_DH"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00873">
        <property type="entry name" value="gnd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006765">
        <property type="entry name" value="PRK09287.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11811">
        <property type="entry name" value="6-PHOSPHOGLUCONATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00393">
        <property type="entry name" value="6PGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03446">
        <property type="entry name" value="NAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000109">
        <property type="entry name" value="6PGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00076">
        <property type="entry name" value="6PGDHDRGNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01350">
        <property type="entry name" value="6PGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 16" id="KW-0311">Gluconate utilization</keyword>
    <keyword evidence="7 12 16" id="KW-0521">NADP</keyword>
    <keyword evidence="8 12 16" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10 12 16" id="KW-0570">Pentose shunt</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="6-phosphogluconate dehydrogenase C-terminal" evidence="17">
        <location>
            <begin position="181"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="13">
        <location>
            <position position="185"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="13">
        <location>
            <position position="192"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="12"/>
            <end position="17"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="35"/>
            <end position="37"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="77"/>
            <end position="79"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="105"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="14">
        <location>
            <position position="105"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="14">
        <location>
            <begin position="131"/>
            <end position="133"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="14">
        <location>
            <begin position="188"/>
            <end position="189"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="14">
        <location>
            <position position="193"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="14">
        <location>
            <position position="261"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="14">
        <location>
            <position position="288"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="446"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="452"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00018193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR000109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR000109-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR000109-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR000109-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU000485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM01350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="CAG5104264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="482" mass="53050" checksum="C511C303F8DCE250" modified="2022-05-25" version="1">MSEPTADIALIGLAVMGQNLILNMNDHGFVVCAYNRTTDKVKAFLENEAKGTKIIGAFSLEEMVSKLKKPRRVMLLVKAGSAVDAFIEKLIPLLSAGDIIIDGGNSDYRDTERRTIDLEKRGLYYVGSGVSGGEEGARYGPSLMPGGNPKAWPHIKPIFQAICAKADGEPCCDWVGETGAGHFVKMVHNGIEYGDMQLICEAYHIMRDALRMNPEEMASVFDEWNKGKLDSFLIEITRDILKFKDEKGFLLERIRDTAGQKGTGKLTVNAALEYGVPVTLIAESVFGRFISALQNERIEASGVLGGLLDVYKGDRKEFLKDLGKALYASKIISYAQGFMLMREAAKVNNWNLNYGGIALMWRGGCIIRSAFLGNIKEAFDKNPKLSSLLMDDFFARAMKECHMSLRKIVSAIVMIGIPMPALSNAIAFYDSYRAGKLPANLLQALRDYFGAHTYELIGQEGVFVHTNWTGRGGNVSATTYDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HQ80</accession>
    <name>A0A8J2HQ80_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS13668</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5109032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HQ80"/>
    <dbReference type="OrthoDB" id="8192724at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5109032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="147" mass="17337" checksum="31B761A776A13AAB" modified="2022-05-25" version="1">MNNYLFFITADELQTNELDEATLNQLSNYLSSLLSQPIWNTPLVIVEDPLLLDEVEDSSELDMMPSVNKRSRYYRRYPWKRQHSRPGNSLDYESLHLCTPSRNDVYQLLVALHQVRNGEKQATVNFCKRRRPVSKVFTSIRFLGRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HRR3</accession>
    <name>A0A8J2HRR3_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HICCMSTLAB_LOCUS12046</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5105998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HRR3"/>
    <dbReference type="OrthoDB" id="6414306at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050888">
        <property type="entry name" value="ZnF_C2H2-type_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24406">
        <property type="entry name" value="TRANSCRIPTIONAL REPRESSOR CTCFL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="324"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="801"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="298"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="363"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="896"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="962"/>
            <end position="987"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="363"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="382"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="900"/>
            <end position="913"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="966"/>
            <end position="987"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAG5105998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="1147" mass="128041" checksum="8015C07F6076FFA3" modified="2022-05-25" version="1">MNNKEDLLKICLPCSVSLIKLPTSEINKWRKRTTERNYSCRGRQVFDSSLLSHVLDDSSSSIDLDNGNINKNDDNSLIQQQTEFKKINTCPEFKLINDDDDDTLLPTITSNSIVVESLSDIHDNKDDINKEDVPAGWKYKKKDELISESTTNNTIMYNKNENPVPIEQQSPTLVNRQLENIDTDSNKKSLNKSCHLIKEVRIISPRLEEIDDPHVRQWQLKTASAANIKAAAATTITTATTTTTITTTTTTTTTTTTTVIVPSNSTITKTDVTTTTNSNESQFQLASTSHNDITSKKIIDKSSKNMSKNGQRTKRKLEPKSKTLDCNVCSRIFDSTEELAEHIYTHTARELQQRFVLAQQEKQQQQIQEISNSQESKNLNNNDDDDDDDDDDDVLLIDESCQKFDNNVQLPILNQTKIVTTILPSSSLAVESEKTNSKVTICYCHNNYKNNECHVQIEMVLFCEICRIFYRRGECFETHYRTSPKCNENSGGRSRRLVKLFCITCDIVFDELTNMRQHIEEHVSIDTNKSITIVCNICKVVFSSIGTIFNNHWYNHVRDPMFIAIVEPSKLAPIISKCATRENIVVPNFILNNNNNNQNSNIVSSVVDSTENLNFAPLSKIITNNNNNNNNNNNSSLITKFNNISTKEPPTYNKNVELIVNNQRQIQPSVEFINVVKNFNKNSNSVINSHKTKTTCDDKNEIASKKPSQSPVNTKTQNYLHYNNIENTKPNNIEEIILMEETPPPPPPPPTTTTTTAVAETTLDNNYDIEEDITDETNYLDKPKKFLRVKNFSELQAVKNFICQHCKAAFENVTSLNEHLIGHTSTLTKNLKGQIPTMKAALILPVNVPDNNTAVTTTKVTSMIMNFSIPKTSSATINSTTTTTTVSSIPTIIEKNSDLNSNKGNSSSNTTGNKIHKDNQKSFAVIMACPVCLSYQCQKQEDLVEHLSSVHCTNTNDINTLSTQPSSSLSSSSSSSSSSSSSSSSSSSLTVVASSNEKQKMFSCKFCKFDTLDKNKIIQHVLQHNITTTAAVVATETQVKPSAGGESLSQSPSNQIQFTPVNNTNNVSNIIIKPITAAATTTTTINCPHNCPICISYQSNSLDDLNQHMRMNHYSCLQGNGLLLCLQCPFLQGFQGPEALKKHKDTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HS07</accession>
    <name>A0A8J2HS07_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HICCMSTLAB_LOCUS12212</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5106342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HS07"/>
    <dbReference type="OrthoDB" id="10265785at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd18045">
        <property type="entry name" value="DEADc_EIF4AIII_DDX48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000498">
        <property type="entry name" value="Eukaryotic initiation factor 4A-III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="9">
        <location>
            <begin position="30"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="7">
        <location>
            <begin position="61"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="8">
        <location>
            <begin position="167"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="6">
        <location>
            <begin position="30"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAG5106342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="318" mass="36159" checksum="9AD35B7AAB538F0C" modified="2022-05-25" version="1">MAEGKARRVAQTEDLSNVEFETSEDVEVINTFDNMGLRDELLRGIYAYGFERPSAIQQRSIKPMMKGRDVIAQAQSGTGKTATFSIAILQSLDTQIRETQVLVLSPTRELAVQIQKVILALGDFMNVQCHACIGGTNLGEDIRKLDYGQHVVSGTPGRVFDMIKRRTLRTRAIKMLVLDESDEMLNKGFKEQIYDVYRYLPPATQVVLVSATLPHEILEMTSKFMTDPIRILVKRRVLITTDVWARGIDVQQVSLVINYDLPNNRELYIHRIGRSGRFGRKGVSINFVKTDDIRILRDIEQYYSTQIDEMPMNVADLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HSS1</accession>
    <name>A0A8J2HSS1_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Olfactory receptor 125</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HICCMSTLAB_LOCUS13867</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5109231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HSS1"/>
    <dbReference type="OrthoDB" id="6604226at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005549">
        <property type="term" value="F:odorant binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004984">
        <property type="term" value="F:olfactory receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004117">
        <property type="entry name" value="7tm6_olfct_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21137">
        <property type="entry name" value="ODORANT RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21137:SF35">
        <property type="entry name" value="ODORANT RECEPTOR 19A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02949">
        <property type="entry name" value="7tm_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0552">Olfaction</keyword>
    <keyword evidence="8 11" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="9" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="37"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="127"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="192"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="248"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="276"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAG5109231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="349" mass="40184" checksum="FCCED4BA16F09F73" modified="2022-05-25" version="1" fragment="single">MKVKSEFVVRILKIFGELLSIWPYFGSKLVVKIIQEVRWLFSTLNLILIVTPIAFGVYQDVYKNKPLNVLQRSMSMVMHLESLMNCFLWKWKDRKLKKLLLEMCDYVKSTKGRDKNIFDRLTHQCSLLYTLIAVVCTMTSISFICSPIFMSQKLLPSSAHYPFKIEPHTVRHYFLYTQQAIAILQTGLHHTIPPITIAVLLTYVIAKLKVLALKLKTIKTIDELGDWIQRHQECIKYFTLLEKTIRFVILKSFIFITTTVIFAGVLAIHSSGINEIIRLVFSVATGFIALYVYVSAADDLHELVSSMRKSIIILIRRTQKPLAISVKGIIPALTRIFYASVRSRSTDFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HT24</accession>
    <name>A0A8J2HT24_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS14083</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001743">
        <property type="protein sequence ID" value="CAG5110361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HT24"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="24"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="83"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5110361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="170" mass="19820" checksum="F9F94EA547413ED9" modified="2022-05-25" version="1" fragment="single">IQKLISGNFYIREMLDHCGTSYEMATLFGMIFGVISGIIKIILLNLSRDSTSFILKNIIDDWWIIKEKKSKFIMKKYASLNRMLFYGLLTPFLMYTVKLTLEKIPHTVLIDNTTVLLRTIPISSECWNFSDTPTIIYIIRFVWRTFEFMIYNIVSCGIDLNAHLRANGNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HU46</accession>
    <name>A0A8J2HU46_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Similar to how: Protein held out wings (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HICCMSTLAB_LOCUS13635</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5108999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HU46"/>
    <dbReference type="OrthoDB" id="6777263at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048024">
        <property type="term" value="P:regulation of mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045071">
        <property type="entry name" value="BBP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055256">
        <property type="entry name" value="KH_1_KHDC4/BBP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11208:SF125">
        <property type="entry name" value="KH DOMAIN-CONTAINING RNA-BINDING PROTEIN QKI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11208">
        <property type="entry name" value="RNA-BINDING PROTEIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22675">
        <property type="entry name" value="KH-I_KHDC4-BBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50084">
        <property type="entry name" value="KH_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="K Homology" evidence="3">
        <location>
            <begin position="46"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG5108999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="264" mass="28460" checksum="66B7F2819DBDD1A3" modified="2022-05-25" version="1">MSAMRLIDMRLKIVGYKIAKVRASLFQISGVKKEPLTLPEPEGEIITLTEKVYVPVKEHPDFNFVGRILGPRGMTAKQLEQETGCKIMVRGKGSMRDKKKAEGEDELKKRQLMELAIINGTYRDSNTKVAAAAAFDIAACDEEWRRVAAAAAETQRLLPGLGSQMRSPNAPLGAPLILSPRISVPTTAASLLNGSGPPGSILSAGDPHGLIYTPYADYANYAALAASPLLTEYADHSGAAAAAKQRRHLGQIREHPYQRAGALS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HU74</accession>
    <name>A0A8J2HU74_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS13727</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5109091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HU74"/>
    <dbReference type="OrthoDB" id="565904at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035153102" evidence="1">
        <location>
            <begin position="17"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5109091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="125" mass="13976" checksum="B1073E57FA74B352" modified="2022-05-25" version="1" fragment="single">MFRLAISFCLIAASLSDSLQPGPCPEITVDPINLDKVAGVWLEHKRSLNNWGNLEKCAKAIWHVPHNGIAKMAGKWYGYARSSNNRDEAERCPIFNWIQIDDGRTLFVFSDISALINDNSTIVAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MD16</accession>
    <name>A0A8J2MD16_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">PGRP.4_Cc</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HICCMSTLAB_LOCUS3488</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the N-acetylmuramoyl-L-alanine amidase 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5082210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MD16"/>
    <dbReference type="OrthoDB" id="7553606at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008745">
        <property type="term" value="F:N-acetylmuramoyl-L-alanine amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045087">
        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009253">
        <property type="term" value="P:peptidoglycan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06583">
        <property type="entry name" value="PGRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.80.10">
        <property type="entry name" value="Peptidoglycan recognition protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036505">
        <property type="entry name" value="Amidase/PGRP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002502">
        <property type="entry name" value="Amidase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015510">
        <property type="entry name" value="PGRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006619">
        <property type="entry name" value="PGRP_domain_met/bac"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11022">
        <property type="entry name" value="PEPTIDOGLYCAN RECOGNITION PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11022:SF41">
        <property type="entry name" value="PEPTIDOGLYCAN-RECOGNITION PROTEIN LC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01510">
        <property type="entry name" value="Amidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00701">
        <property type="entry name" value="PGRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55846">
        <property type="entry name" value="N-acetylmuramoyl-L-alanine amidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0391">Immunity</keyword>
    <keyword evidence="2" id="KW-0399">Innate immunity</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035182442" evidence="4">
        <location>
            <begin position="26"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidoglycan recognition protein family" evidence="5">
        <location>
            <begin position="47"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAG5082210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="211" mass="24071" checksum="E54A28311C3B78FE" modified="2022-05-25" version="1">MSLMKKEILILLVVCNILQFVPCLAMRPPFIYVQTSNDSSKNSRLEPKFVNPLSWGAVARLNNSPKLKNPVPYVIFYQTNTEECYNRTHCSEIVSRIHKTRMKLMNDNLQYNFLVGGDGLVYVARDWDTTSGVTNGYNGRSIGIGLIGNYFSKVVPDALIRNAIKLIEFGTKNGKINEDAHYISIPPMAFIVEYVDEVMQKFMDKFDYSYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MDP5</accession>
    <name>A0A8J2MDP5_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Similar to zfr: Zinc finger RNA-binding protein (Danio rerio)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HICCMSTLAB_LOCUS3912</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5083723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MDP5"/>
    <dbReference type="OrthoDB" id="8898434at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003727">
        <property type="term" value="F:single-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1410.40:FF:000001">
        <property type="entry name" value="interleukin enhancer-binding factor 3 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000898">
        <property type="entry name" value="zinc finger RNA-binding protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.460.10:FF:000010">
        <property type="entry name" value="Zinc finger RNA-binding protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1410.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006561">
        <property type="entry name" value="DZF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049402">
        <property type="entry name" value="DZF_dom_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049401">
        <property type="entry name" value="DZF_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003604">
        <property type="entry name" value="Matrin/U1-like-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022755">
        <property type="entry name" value="Znf_C2H2_jaz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45762">
        <property type="entry name" value="ZINC FINGER RNA-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45762:SF3">
        <property type="entry name" value="ZINC-FINGER PROTEIN AT 72D, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20965">
        <property type="entry name" value="DZF_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07528">
        <property type="entry name" value="DZF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12171">
        <property type="entry name" value="zf-C2H2_jaz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12874">
        <property type="entry name" value="zf-met"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00572">
        <property type="entry name" value="DZF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00451">
        <property type="entry name" value="ZnF_U1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51703">
        <property type="entry name" value="DZF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DZF" evidence="5">
        <location>
            <begin position="482"/>
            <end position="918"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="280"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="548"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="699"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="877"/>
            <end position="925"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="324"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="559"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="699"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="884"/>
            <end position="896"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="907"/>
            <end position="925"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAG5083723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="925" mass="100394" checksum="D498383698514C32" modified="2022-05-25" version="1">MAQNNYFGFTHGGTQYGATSAAYQTGQAGYAVTPAATAATYTQRPAAAAATGYETYQAAAAAAATGTTYAGFVSPVAANPGTVAQTYDYGYGRPAPAATYDATKTYYQQPAAAAAAATYTTTETHYQAAKPAYSTTSAYTGTARQATTTGQAKTYQAASTAYQQSNPTQNATYSSGYTAPATPAAAPAAATNKTASTAYSGYDAALYSAATMYVAQQSANSNNTTNQKTGGWQGYGRKGFGAGGSGMKSMRAKPPPKPQQLHYCDVCKISCAGPQTYREHLEGQKHKKKEASMKVPQQPPARGAAGNLGTVNQNAAAEAKTEESAVEESAEESLTEEKDIQPVGQEYIEENKSEDGKIISFNCKLCECRFNDPNAKDMHMKGRRHRFAYKKKVNPDLVVDIKPSLKQRKMLEEKHRRQQAREEFTRRREEMNQMGPMGMMGPMMDEEMIYWEERRRYEEECEYYEWYRRCGRGPGAPPMPPRPFPGPPGMMFSVVPRRSDDKHVDAHHSSIYPKEEELQAVKKIVSHTEKALKLVSDVLAEANKKTMPATGNATTPAAEVKKEEAEKKKDENTTSFANPKEKEDLRVIRDVMRVGNLAKGLLLSGDNHVCLVVLCAEKPTKTLLNKVAEILPSQLKIVAPEETYNVGKHPESAALTVSGGTVTVSVTLTSPLMRETAKPPATAACCAFFVGISDSAGQQQGAAQPQTTPATPAVTKPDPPDVLPKAKCLEALAQLRHAKWFQDNEAGRIAKAHHKAINQARASSLQNCVIIIRIMRDLCNRVPTWGPLNPWALELLTEKVINTAGCPLSLGEALRRLLECVAGGILLPGSPGIADPCEKEPTDAIGNMTAQQREDITASAQHALRLVAFRQIHKVLGMEQLPPPKHKGRFPRKRRRDNSNGEGNDCEASKKDKKAEETKMETDSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MGK2</accession>
    <name>A0A8J2MGK2_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Myosin light chain kinase, smooth muscle</fullName>
            <ecNumber evidence="5">2.7.11.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="21">Telokin</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="27" type="ORF">HICCMSTLAB_LOCUS3212</name>
    </gene>
    <organism evidence="27 28">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="27" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Myofibril</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="27">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.18" evidence="5"/>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5081181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6070751at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030016">
        <property type="term" value="C:myofibril"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004687">
        <property type="term" value="F:myosin light chain kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009653">
        <property type="term" value="P:anatomical structure morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040017">
        <property type="term" value="P:positive regulation of locomotion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060298">
        <property type="term" value="P:positive regulation of sarcomere organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045989">
        <property type="term" value="P:positive regulation of striated muscle contraction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd14103">
        <property type="entry name" value="STKc_MLCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000069">
        <property type="entry name" value="Alpha-protein kinase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000425">
        <property type="entry name" value="Myosin light chain kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000175">
        <property type="entry name" value="Myosin light chain kinase, smooth muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000080">
        <property type="entry name" value="Myosin light chain kinase, smooth muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000107">
        <property type="entry name" value="Myosin, light chain kinase a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000032">
        <property type="entry name" value="palladin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000612">
        <property type="entry name" value="palladin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:001223">
        <property type="entry name" value="Sidekick cell adhesion molecule 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:001053">
        <property type="entry name" value="Uncharacterized protein, isoform D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:001452">
        <property type="entry name" value="Uncharacterized protein, isoform F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47633">
        <property type="entry name" value="IMMUNOGLOBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47633:SF7">
        <property type="entry name" value="TITIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="16 22" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="15" id="KW-0106">Calcium</keyword>
    <keyword evidence="18" id="KW-0112">Calmodulin-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="19" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="20" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="14" id="KW-0418">Kinase</keyword>
    <keyword evidence="17" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13 22" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="28" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ig-like" evidence="25">
        <location>
            <begin position="600"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="25">
        <location>
            <begin position="701"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="25">
        <location>
            <begin position="823"/>
            <end position="912"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="26">
        <location>
            <begin position="1052"/>
            <end position="1152"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="25">
        <location>
            <begin position="1156"/>
            <end position="1247"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="25">
        <location>
            <begin position="1276"/>
            <end position="1359"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="25">
        <location>
            <begin position="1376"/>
            <end position="1466"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="25">
        <location>
            <begin position="1495"/>
            <end position="1531"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="25">
        <location>
            <begin position="1612"/>
            <end position="1695"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="25">
        <location>
            <begin position="1771"/>
            <end position="1859"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="25">
        <location>
            <begin position="2042"/>
            <end position="2130"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="26">
        <location>
            <begin position="2134"/>
            <end position="2234"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="24">
        <location>
            <begin position="2278"/>
            <end position="2533"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="1"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="509"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="577"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="803"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="1722"/>
            <end position="1742"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="1869"/>
            <end position="2029"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="23">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="23">
        <location>
            <begin position="81"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="23">
        <location>
            <begin position="220"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="23">
        <location>
            <begin position="354"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="23">
        <location>
            <begin position="406"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="23">
        <location>
            <begin position="416"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="23">
        <location>
            <begin position="578"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="23">
        <location>
            <begin position="803"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="23">
        <location>
            <begin position="1723"/>
            <end position="1742"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="23">
        <location>
            <begin position="1869"/>
            <end position="1881"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="23">
        <location>
            <begin position="1937"/>
            <end position="1952"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="23">
        <location>
            <begin position="1981"/>
            <end position="1994"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="23">
        <location>
            <begin position="2011"/>
            <end position="2029"/>
        </location>
    </feature>
    <feature type="binding site" evidence="22">
        <location>
            <position position="2307"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00021842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00022860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00030959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="EMBL" id="CAG5081181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="2908" mass="328287" checksum="F5F8B0B597FB31D5" modified="2022-05-25" version="1">MEVEVLRMPDKKDESSKIIEEIDQGVDVKDALKVKRKSSDKGEDKMEKDKREEESSKDKLEKSGSQDGEENKRVSVKSKSRKSEVEDKGVEDKNRDSIKGRKKSDDKSKDVEEKRRTSLKEKAEDKKKEVEDRTRDSLKKKHSEELGDENKEEEKRRTSLKEKAEDNGENVDKKRRESLKKSEKSEEKNEEAEKKKKIEETTRDSLKKKHSGELGDENEEEKRRTSLKDKDTDIEEKTRDSLMKKKQSKESDDKSKDVEEKRRTSLKEKVEDKNKDVEEKLRDSLKKKSEKNEEAEKKKEVEEKTQDSLKKKKQSNDKSKDVEEKRRTSLKEKAEDKNKDVEEKRRDSLKKKSVKSDDKDKNEEEKRRPSLKDKEEKSKDKDKIEEKRRTSLKEKDESNDKDSDKKRRTSLKKKSEKSVDNDKDVEERRLSLKIKSEEKEETKVRQLDIQKTDKESKIIDAPREEKDKPVVQKTEEKSRDTKEKYQRVNEDNQVAAKQLDLKLPKATIDSELDSEFSESSVSTLKNVSTKERYKRSNPPMIEIDYDESSPREPSRRSNLSRKYRDLESIDLDDKSLGVYSTDTSRTTGVSHGPRDRGKKPSFCTKLTDRTAAESSRIKLTCAVLGEPEPAVYWLKDGKLLPPSSNRHGTTFENGMASLELYTVRPSDTGEYSCIARNPHGQACTEAKLKVYAGYEPTPTTPTFTRTIKDTYLREENTLVLECRVRGQPTPAITWLKDGQVLEISDRYQQCDLPDGLCRLKIFNPDFYDSGLYTCRAENDTKLSDRTSHLVDFEATGRAAQSSRSWRGSSYNDITSTEKDTGRPRFSSYLTDHSVPVGGTIALQVEVKGVPPPDVTWMRADKKGSIAVPKARTFADSGVYTLIVPDATEYETGTYVCRASNSYGHVDSTATVEVVSGSMGDGGKPAIFVSRPPDKVIIVAVGEDVSVSFRTNGIPKPKVIWMKGLRDITSGPRSYKEGHDDYVRLTLKRACPSDEGTYCILVKNRYGCDRSFFSVQVKQRARSLTPSPDWGSVDTDSLLANIHDKERSYLKQVPGPISTEPVVIDGGRNWLALTWGKAEQRGSAPVVAYRVDGWLLGGEGGARWVELGVTPINAFDAFNLRPGEEYKFRITPRNRYGWGEPVTMTNSVTVREVVKFPEFTKILPGQLKALEGTVLSLDCEVSSDSLAHVKWYRDTTEIENGQDSRFTTYFNGTKCTLMIGNISENDSGRYVCEATNAAGRVSTFARVQVVEDPKIVEADLKLRKMRSSDVANEERPPEFTMRLRDRRVQATYPVRLTCQVTGYPEPEVTWYKYREELYSQENISIWNDEAHFHTLEINRSTIDDSGIYMARAKNIYGSVSCRCHLTVDKGIRAYIAPEFLRHLDSIYTVKAGGELRMTAQIEAYPTVGVTWHRDGHRLRPSRDVVMTLNHDGSVELDLAHVTPRDAGLYCCTATNEVGQAETTTRVTVLDNDDIKSSDINQSAADESLDIPYSKEPVFVTKPLSTEAFEGDTVIISCEVVGDPKPEVIWLRDFLRPDYYKDAPHFRRVGAGPQYRLEIPYAKLDFTGTYSIIAKNCHGEAKAVISLQIYARGQGKEHSGMESTIKHGNVQTLPVIKRPLRDLRCCDGDAITLVCKLHAKPEPDIRWEKGGKLLPLGGDFAADFDGETARLSIQHVYPEDEGEYTCVAYNELGKAYTSACVIVDVPEGKETALSRRLIKPPGFLSANSTPISTPRSTPVRSLSPSCCKREVKPVTKTARGYTGGRRPRMPTSPKFYAVPHNKVAEEGETVRFQCAIAGHPVPWVTWDKDGISITPTARISLKESDDVRILEITEITHEDAGLYRVTLENDVGRTEATARLEIIKGRRSSISRPIRTRSASPRTYSIYGGRNPSPTPRSDSRLQPPRISDNYSGGRGTSPTLPRWHYRNGNAVNDEKINAKTSSTELNKPRSSSVPRHCKMEREKSNVKQVSESPMKNRKTRPSQHVTSPTQSSARKTSIPVRRKSSVKLNSNKQDKIDSKDKEKNFNSKDKNLKKKVKEELKSPVILTVPADIIALRGAKVMLLATYDGYPRPTVRWLRKGRDVTLDDKTEIETSAGLTCLTLLNVTTEEAGKYEVFIENKLGKDSRHVNVTVEGPPEPPAGSPAIQIIKDSRGVTLSWRSPVYDGGCAVTGYSVEMRRGEEPCWVAVAEAKHSLSHTISGLDPEESYQFRVRAENIHGLSEPGMESETVIITKSETRKVTSSISGFSLDPDEDTEDEIEPAYEPCVVAPESGFLFDERYNVLEELGKGKYGIVRRIVDKSNGSSFAAKFIRTIKAIDRQQVNDEINIMNMLRHPKLLRLIAAFESPREMIMVTEYISGGELFERVVADDFTLTEKDSILFVRQICMGVDYMHDNLVVHLDLKPENIMCHTRTSHRIKLIDFGLAQTLKLDTPVRVLFGTPEFIPPEIIGFEPIGTESDMWSVGVICYVLLTGLSPFMGENDAETFANITRADFDFDDKAFSAISEEAKDFISGLLIKRKESRMSAKECLKHPWLAQRAESMSRVALPTDKLKKFIVRRKWQKTGNAIRALGRMAILSANSRKNSESLSDVTKESEETTPTNEDIIITEDSLDEPINTINPDNSEFSNGRISKADSDELQITELSSDECVDSHEIDNYDSSTIIETQRSISPDDFTKIEDKIDDDLLSSDFKKIKIISDDPSNKTDTFISELNSSEENIYTVDISTESLKTTTEIHEEFSENYCSITSLHINEPSFEVKEEITISRISLQDKDDNKFVNLIDQQNLNNKSSIVNNNNNNNNDDKIPATRPNFIPIESNTNSHGSVCKPWCKTNSSSLDTEDEISRVRGHSPLHRVVRTGSVSRTAKMFEQEQVSSSVKQQLSPGSRIVLPAANARPQNERIRKAFAFWNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MH61</accession>
    <name>A0A8J2MH61_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Similar to Gtf3c1: General transcription factor 3C polypeptide 1 (Rattus norvegicus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HICCMSTLAB_LOCUS3594</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5082557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="68020at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000127">
        <property type="term" value="C:transcription factor TFIIIC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042791">
        <property type="term" value="P:5S class rRNA transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006384">
        <property type="term" value="P:transcription initiation at RNA polymerase III promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16169">
        <property type="entry name" value="Tau138_eWH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056467">
        <property type="entry name" value="eWH_GTF3C1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044210">
        <property type="entry name" value="Tfc3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035625">
        <property type="entry name" value="Tfc3-like_eWH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007309">
        <property type="entry name" value="TFIIIC_Bblock-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056428">
        <property type="entry name" value="WH_GTF3C1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15180">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR 3C POLYPEPTIDE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15180:SF1">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR 3C POLYPEPTIDE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04182">
        <property type="entry name" value="B-block_TFIIIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24101">
        <property type="entry name" value="WHD_GTF3C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23704">
        <property type="entry name" value="WHD_GTF3C1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="General transcription factor 3C polypeptide 1 winged-helix" evidence="8">
        <location>
            <begin position="30"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="domain" description="B-block binding subunit of TFIIIC" evidence="7">
        <location>
            <begin position="193"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="GTF3C1 extended winged-helix" evidence="9">
        <location>
            <begin position="913"/>
            <end position="1014"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1027"/>
            <end position="1058"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1837"/>
            <end position="1867"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1882"/>
            <end position="1909"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1029"/>
            <end position="1050"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1837"/>
            <end position="1857"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1893"/>
            <end position="1909"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="2457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF23704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF24101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAG5082557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="2457" mass="283501" checksum="78B3AC23531FDFC0" modified="2022-05-25" version="1" fragment="single">VTIYYKNYLIKIRMHLTRVDTSVFAPSANLVNSVIDEVALEGLDGITLDTLWIRLGARLQTQDEFPPAFKEQVWTICTSTRGIHFYILEVPRAPLIIYDRYEYVDPDLGIITEPDDIPDDIYEYYPVDDVKNGIKGSCKSYHTRKLVTNMDSVSLQEASEKYGAALVIVASQELRQEALLEDSVSPTLELSVVQYCFLERVGRSRYHGEVTQGKNSLSVLNEDPKTLFYYRKLLLKHKLITKQSHYQKTSGHGSAGSLMHLPRFFVERKPKMVFLAERIIEMLKSRENYLMDYREIKKELQIEHSIKRLFKTSFFQKVARADLKVRYRELYPNALDSEWQRKGCPSKEKIIQAVQLLDPKVDANTLWNKEDMVDDEDCYDLDVSNQLLNEPLLKQANSIVERANVHGISQRDLGMQMGMTKLQSRTIIRNLSKLNAIGTYMDFSGRQRVSKFVSKKYEKRSRISKQFNSEIRKMNKLRKETLNEVARPNATTAMDFFYPLGSSDNSLNITSIDYRTVETTPAIEYHPAREENIDDPNIIVNDFETVNVDTFNANDADKIEDFSEEQTFGETKGQIISKATETIISGDIKFDTRNSQQNAAEENCIEATINCPTAKECNLNIEMEIVNTPIKLETINVDRYHLFSVANKVLNKYSKVKNKSIVQKRSHFKVGFFNVAHLDLSRLSSISCVNRWRCKKRKVKSAKNQNGKPKEAIAVSSVGEKCVSGKSKSNSVDTKECILPDNLEPNPNIENHESECTVVSPALHPEDHILPERIDSNILDGENNSRKRIHPDESLSNEDINVKRIKISSNLFHEQPANTEMNAVINIEPEDYNSGFYNQDNYYNQDYPEGYYDEGYNPEEYYNAEGYNPENCNTEGYNPEESYNLEDNYDNSWVDDDDDEKIIDATTTSTAYSYRMLKRLNMIITMVKEHKVVDDPSKLMKMINQHEESEGIDVKMDKKSLMRMLQRLARDNLVKNMKLTLSGNGRKKVLFFICDKNINVNHSVIQSAVEQAKIKFCLMPPTKKVVKMNNRSGTSNETTAESTDPTNADSTDLVANEKDNPKVPTLEVKFDLKAGRDYGYKPKFIRMKIMHKLLFYLIYEYRGENLSKIDQIERLRAEGNEISEKMAEEMSEIYYRDVDWRMFIPPLPQHSTWERGWAMISDIILRLPLSIFLEIHKLPFYLPALNYYLNHPIRKHYLMKDLPMLIRSQIFRNRKYIYSIIETIQRLAYIGLVQYGPQKFKEKDHVFIYLNTRSQLVDTTPSAPGYHKIEEREYSVQSYTFDRLQTVENYWYDMWQICVCTRLGGRQAVEGTEITLEDLTKKPEMIQCLKQVLPNEVVSQDLGILPGDRKGAAGIDSAFFSHLKRNWNWENFHSSVSLRSMKKQSDKERTARLAKVEVKPLKYTEFKGLKKVTGPTTIIANKPPVKKPKVNPNPAPPKLVVSTVTHRPDKIVRKVLPRKRQERKRVHYDEVDHQALQNMKMQRVNWDAREDHILSICKIVLVYLSPNPRAQLLSFSVIRDVLKFYSKTSINKTSRACQRRMFNIYKRPQVALAVTLGVEELKENPYIRKKYHNIVDVIRSNYEPHQHDEKITSVFKAICHYVARKHHLSQKDPPESTHQPATLGEFHLLFKISHPQGPEEGFTKPVRNINDIHSSTINSIIFSSICSGKDRRSSTYQLYRIYQQYPEFLLKSAITQIKNDKTVSIKKQFESVLKRIGNGCCMPMTSSQIQLSCKYNYIFQSVFSLEIFNEAQVFLQKLIEGYASNSLGSEHGVEFDSPTGGVILGLQEFLANQNLDFNIKIPDYVIVLDQEMPEHDTGFKKVAERYQNILCSLENAETREGQDKEKQSQDLEQREDMSENDDSPADISVVAVKATKKNPLRKDSWGWQKSDTGSNSSSGLVLNSSSQSNIQRPVRGCQFVLDDSDDELEFKTSVDGREIIITKSDIDNNKSSFIENDMHEAFRQTKLGHLNDLPENLGSDDQEEDPREALLNLVNQVTMGTSIDELNRIVNEHIPMDVDDERITKQSIRRAAIKRGRTDQDDGFEFVNIEEFDPVNEEPESRRNVSNMVNDIIANVNYCHESRNQSRVRDEDTGETRKNFTRIALLKVRAELNEKLHNLPDSHHAHEYFAVSKFRLYYSMPKIDKEIITNPHFVIDDKVKENLFLLTNDSYKNVVQDLNKFAVFPKNRPDYESVKEDLEIQGTIESFEIDLIYDYVRNKREPGATLKELTNKFYRVLEEKLYDILSYMTDCRLFLRSGVTEMHYIHYSYAEPWYVESIKILRLLRESLPLFPPGNIDSAIKNLDFSSAEKINVVVRPWIRIDGTVNRMILEKMLGAILSHCLMHPGIALSQVQTKFVPALQPYHTRELVEILVKLDCLSLRVVRKPPCTLFSSASSIKLYYPAKSDGSSELESEMIVETTIGAVIKFGTFIRYYLSRKANINDSTDNNDGNGESESI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MIN9</accession>
    <name>A0A8J2MIN9_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Ionotropic receptor 218</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">HICCMSTLAB_LOCUS3853</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5083485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MIN9"/>
    <dbReference type="OrthoDB" id="8182981at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015276">
        <property type="term" value="F:ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019594">
        <property type="entry name" value="Glu/Gly-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052192">
        <property type="entry name" value="Insect_Ionotropic_Sensory_Rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42643">
        <property type="entry name" value="IONOTROPIC RECEPTOR 20A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42643:SF39">
        <property type="entry name" value="IONOTROPIC RECEPTOR 56A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10613">
        <property type="entry name" value="Lig_chan-Glu_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-0407">Ion channel</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="7 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 14" id="KW-0675">Receptor</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="244"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="305"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="485"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="domain" description="Ionotropic glutamate receptor L-glutamate and glycine-binding" evidence="13">
        <location>
            <begin position="139"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="14">
        <location>
            <position position="538"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF10613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CAG5083485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="538" mass="62883" checksum="1D3D191489C526F8" modified="2022-05-25" version="1" fragment="single">IDEIFNKFTKSYKFNYYVKPQTFECQGFFLVSSSVNNLLSAIKNVPTKISTSEILMVIDDTIDYSSELLNVTLYGYSSVNVISRSAKWSLSENYLFPRQFKKGRELQVAAFFNPPLCYLLTSVNKTVKGIDGQFFTAPENEIDGIETKLFVIIAERLNFTWQIRKPNHHYRYGRPNGTTWNGGMIGQLFRNEIDIAFSGIWLKHDHYRFVNLTKPWHQLFINYLVPRPKHRFSFWALTRPLTPGVWLAIFGMIFLYSLYVCTKAWINPHAEIRYRSYITTLIELIARLVGTWAPKRVQGFKIQTVAWHMAGVLIVTAYSCSLATDLTFPDFEKRRFILKNLTWGRESPVPKFDDYFNLNDKYGSQFPKNFQLEKSQEERHEKIIQGNYAIIGRMIDSIFFPENNISSDDLQDYRVMKQSVSDYYVSFAVKPWLVKSFDKVILWMRETGIVTYHLNDVIYRKTPKSLRQVLVEYDIETGATHALELLPLSAAFAFLFFGLFVSSVIFFFELGTVYGDVDAFKNFVKVRMVRFKEKFFLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MKL3</accession>
    <name>A0A8J2MKL3_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS6243</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5092592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MKL3"/>
    <dbReference type="OrthoDB" id="9974841at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035224550" description="Secreted protein" evidence="1">
        <location>
            <begin position="24"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5092592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="121" mass="13746" checksum="B24650290E97AF4C" modified="2022-05-25" version="1">MAAQVLLLLNCALLPRFSRMCSSFPCRAQLIDSKDQQRHSKFTDNFKMIARQLIAKQIRNFTTSAIRRSGHGDPGGYPGAVQLAVQYPQQIQADSLFYYLLWQRISFTIHCSPSPNVEVNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MMG0</accession>
    <name>A0A8J2MMG0_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS8862</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5097757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MMG0"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5097757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="98" mass="10976" checksum="2ABB1584091AD9B6" modified="2022-05-25" version="1" fragment="single">IAGNYFGCVDSPNKLPASKQCTMLNLEPTSSNTWNSSLFSKSNKTRQGESYTFELRIKNQTIDLAINSSSRTLPGSTFTLILTPIMMTTSFIWDARMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MMV8</accession>
    <name>A0A8J2MMV8_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to jockey\pol: RNA-directed DNA polymerase from mobile element jockey (Drosophila funebris)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS8332</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5096682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MMV8"/>
    <dbReference type="OrthoDB" id="7700723at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19446">
        <property type="entry name" value="REVERSE TRANSCRIPTASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14529">
        <property type="entry name" value="Exo_endo_phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="domain" description="Reverse transcriptase" evidence="2">
        <location>
            <begin position="485"/>
            <end position="761"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5096682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="1082" mass="123283" checksum="0F4990ED4551DB02" modified="2022-05-25" version="1">MILTLWRIQKKKRGFKKAKSLLILLNSEIICTWNIFWSPAQAPTGLGRPSGGLLTLIDSQIKHKTLDASDSWIITALHHGRLTIITATVYFKPSVDIEDSLLALQLALFPIMDQQDYDIFIIAGDFNARVGSLGDFNMEMLNLNTLSCSRTSCDSTVNHRGKLLLDFMDSAGFVLINGRSKRDTPGQLTFGNKNGSSTVDLVWVDITGLHLVKDLWVEEQITKSDHFPISIELFTPFSQQTNVQPEYPAASQVKLQWSSPGKQAFKNAMRYSPLIAGDFHNMSSDLLYENLCNSITSAARKCGMQISTRPIRKSNHINKPWYDLECSTKRNALYCMLKACKSYKDNSYMWSEYHKLKDNYYKLLKIKKKDHDREVLNKFKNVKSQAEFWSVVKTVRKPSSQPQCIPLEQWEEFLSSIYPEKPSTSGSFFGRDDPDLDAEITLLEVQISLKSVKNGKSPGINGITNEFLKELPDNWLLYIVALFNKIYRTGEIPSDWSRVILHMLLKKGNPQDPSNYRGIALVNCVSKVFTQVLLCRIRVWATKKNLIPEEQTGFEPGRSCADNVFSLFALHHIQSRFKGNAAYLLFIDFKRAFDSVPHEKLWAKLHSMGTSSKLLQFLRNFYANIRMQVRANNKLSNPIDITEGVLQGEILSPILFSLYISDIVSFFKSKGAEGIFLGSSDVLFLMYADDLVLLSTSWNKLLKNLRLLEEYCEINGLTVNVSKTKVMVTSNSGRIKAPGVPKYKNQDLEVVTEYEYLGVKFTSNGKGKSATESAARKGKVATGTVLSIIAKLKANSWYGRLELHNSITQSSMLYLAHLWGLNQNHLEILDTANLVFFKKTMYLPSCTPKYAIRVELKLDHISVKILTAAISWVIKILDMDDSRIPKRCYLKLHSLLDTPYKRSNWIKQLQDILALIGEENLIHSLSSNTWKAKKDSVLAKFQLYKQTLDIARYNTSSACQFCFKRPILEVYPKIFENFPGHITKLVIQLRLANLYACNLSINTHSLKLSPTRICRNCHLEERETINHVVLRCPFYANARLQHFNIEDVEPVAEVLSCLETLNLDQLKKLFFFFKDIFTSTNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MN56</accession>
    <name>A0A8J2MN56_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Eukaryotic translation initiation factor 2 subunit 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Eukaryotic translation initiation factor 2 subunit alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HICCMSTLAB_LOCUS9422</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eIF-2-alpha family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5100176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MN56"/>
    <dbReference type="OrthoDB" id="1685042at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005850">
        <property type="term" value="C:eukaryotic translation initiation factor 2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04452">
        <property type="entry name" value="S1_IF2_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.190:FF:000001">
        <property type="entry name" value="Eukaryotic translation initiation factor 2 subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000795">
        <property type="entry name" value="Eukaryotic translation initiation factor 2 subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1130:FF:000001">
        <property type="entry name" value="Eukaryotic translation initiation factor 2 subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1130">
        <property type="entry name" value="EIF_2_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.190">
        <property type="entry name" value="Translation initiation factor 2, subunit 1, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044126">
        <property type="entry name" value="S1_IF2_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024055">
        <property type="entry name" value="TIF2_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024054">
        <property type="entry name" value="TIF2_asu_middle_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011488">
        <property type="entry name" value="TIF_2_asu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10602">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2 SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10602:SF0">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2 SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07541">
        <property type="entry name" value="EIF_2_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00575">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110993">
        <property type="entry name" value="eIF-2-alpha, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116742">
        <property type="entry name" value="eIF2alpha middle domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 12" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="S1 motif" evidence="11">
        <location>
            <begin position="16"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="291"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="300"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00033370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAG5100176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="334" mass="37725" checksum="AC094D86578EF862" modified="2022-05-25" version="1">MPLSCRFYKQKYPEVEDVVMVNVRSIAEMGAYVHLLEYNNIEGMILLSELSRRRIRSINKLIRVGKTEPVVVIRVDKEKGYIDLSKRRVSTEDVEKCTERYAKAKAVNSILRHVAELLHYENDEQLEELYQKTAWYFEEKYKKQKASAYDFFKQAVLDPSILAECGLDENTKSVLLNNIKRKLTSQAVKIRADVEVACYGYEGIDAVKAALKAGLALSTEELPIKINLIAPPLYVMTTSTPEKSDGLKALNDAIEVIKEKIISMGGVFNVQMAPKVVTATDEAELMRQMERAEMENAEIAGDDDEEDVEGMGDFSGGEDEGEDNKDQEDSQDED</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MN96</accession>
    <name>A0A8J2MN96_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 12">Adenylosuccinate lyase</fullName>
            <shortName evidence="12">ASL</shortName>
            <ecNumber evidence="6 12">4.3.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 12">Adenylosuccinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">HICCMSTLAB_LOCUS6999</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>(2S)-2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinate = 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + fumarate</text>
            <dbReference type="Rhea" id="RHEA:23920"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:58443"/>
            <dbReference type="ChEBI" id="CHEBI:58475"/>
            <dbReference type="EC" id="4.3.2.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11 12">
            <text>N(6)-(1,2-dicarboxyethyl)-AMP = fumarate + AMP</text>
            <dbReference type="Rhea" id="RHEA:16853"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:57567"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="4.3.2.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 12">Purine metabolism; AMP biosynthesis via de novo pathway; AMP from IMP: step 2/2.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 12">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homotetramer. Residues from neighboring subunits contribute catalytic and substrate-binding residues to each active site.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 12">Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.3.2.2" evidence="6 12"/>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5093673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MN96"/>
    <dbReference type="OrthoDB" id="406045at2759"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00132"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00075">
        <property type="reaction ID" value="UER00336"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070626">
        <property type="term" value="F:(S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido) succinate lyase (fumarate-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004018">
        <property type="term" value="F:N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044208">
        <property type="term" value="P:'de novo' AMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd03302">
        <property type="entry name" value="Adenylsuccinate_lyase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.40.30:FF:000005">
        <property type="entry name" value="Adenylosuccinate lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.275.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.40.30">
        <property type="entry name" value="Fumarase/aspartase (C-terminal domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.200.10">
        <property type="entry name" value="Fumarase/aspartase (Central domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019468">
        <property type="entry name" value="AdenyloSucc_lyase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020557">
        <property type="entry name" value="Fumarate_lyase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000362">
        <property type="entry name" value="Fumarate_lyase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022761">
        <property type="entry name" value="Fumarate_lyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008948">
        <property type="entry name" value="L-Aspartase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004769">
        <property type="entry name" value="Pur_lyase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00928">
        <property type="entry name" value="purB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43172">
        <property type="entry name" value="ADENYLOSUCCINATE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43172:SF1">
        <property type="entry name" value="ADENYLOSUCCINATE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10397">
        <property type="entry name" value="ADSL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00206">
        <property type="entry name" value="Lyase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00149">
        <property type="entry name" value="FUMRATELYASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00998">
        <property type="entry name" value="ADSL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48557">
        <property type="entry name" value="L-aspartase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00163">
        <property type="entry name" value="FUMARATE_LYASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12 14" id="KW-0456">Lyase</keyword>
    <keyword evidence="8 12" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Adenylosuccinate lyase C-terminal" evidence="13">
        <location>
            <begin position="385"/>
            <end position="469"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00017058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU361172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CAG5093673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="492" mass="55042" checksum="8FEA1BA6A3B4D371" modified="2022-05-25" version="1">MKKPTKTPEATISASGLLSSFRFHVPPTPRNSPPYPVRYKMRIINTFILILPTDTTETMELGLDIKDDQISEMEACVDKIDFLAAAKEEKATRHDVMAHVHVFGTQCPKAAPIIHLGATSCYVGDNTDLIQLKQGFNILLPKLGGVIQRLARFAEEHKDLPTLAFTHLQPAQLTTVGKRATLWLHDLLADEYDLREARDRLKFRGVKGTTGTQASFLQLFNGDSTKVKQLDALVTQMAGFDEYYSVTGQTYSRKVDIKCVGVLASLGATIHKICTDIRLLASMKEVEEPFESTQIGSSAMAYKRNPMRSERCCSIARHLMSLQNNTLQTAASQWMERTLDDSANRRITLAEAFLSADVILMTLQNITEGLVVYPKVIARHITQELPFMATENIIMAMVKAGGDRQVCHEKIRVLSHEAGAQVKQHGLDNDLVDRVKKDPYFKPILNKLDSLLDASTFIGRSSEQVVEFLQKDVQPVLEIYAGQEQRRVDLNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MPE2</accession>
    <name>A0A8J2MPE2_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">tRNA N(3)-methylcytidine methyltransferase</fullName>
            <ecNumber evidence="4">2.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HICCMSTLAB_LOCUS4464</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="4">S-adenosyl-L-methionine-dependent methyltransferase.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the methyltransferase superfamily. METL family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="4"/>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5087258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MPE2"/>
    <dbReference type="OrthoDB" id="417697at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052735">
        <property type="term" value="F:tRNA (cytidine-3-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013217">
        <property type="entry name" value="Methyltransf_12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026113">
        <property type="entry name" value="METTL2/6/8-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22809">
        <property type="entry name" value="METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22809:SF11">
        <property type="entry name" value="TRNA N(3)-METHYLCYTIDINE METHYLTRANSFERASE METTL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08242">
        <property type="entry name" value="Methyltransf_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037755">
        <property type="entry name" value="Mettl2_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase type 12" evidence="6">
        <location>
            <begin position="137"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR037755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAG5087258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="316" mass="37003" checksum="EB00DE7DD349B631" modified="2022-05-25" version="1">MAESENNKQSRPQFGNRVLKKEDNVFQHNAWDNVEWDDEQQKLAQQKVAQNSEITASEKELELYEIEASKNWDKFYGIHQNRFFKDRHWLFTEFPELAPYKVKDDLSVPEKVELEQKKETKDQKELEENSLTEQRILEIGCGVGNTIFPILAYNSNPKVYLYGCDFSSVAIDILKTHKEYDESRCKAFVLDISQDDWDVPFEPNSLDIVLLIFVLSAIKPDKQIHVVKQIYRYLKPGGLVLFRDYGRYDLAQLRFKKGQCLGDNFYARGDGTQVYFFTQENLKGLFEGCNFKEEQNIVDRRLQVNRVNNLSPLLSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MPE3</accession>
    <name>A0A8J2MPE3_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similar to Uncharacterized protein C6orf136 homolog (Bos taurus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS7772</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5095565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MPE3"/>
    <dbReference type="OrthoDB" id="44820at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018790">
        <property type="entry name" value="DUF2358"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31094">
        <property type="entry name" value="RIKEN CDNA 2310061I04 GENE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31094:SF2">
        <property type="entry name" value="RIKEN CDNA 2310061I04 GENE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10184">
        <property type="entry name" value="DUF2358"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5095565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="274" mass="31511" checksum="44DC0B726EB99A5F" modified="2022-05-25" version="1">MALCVRAIPNKILSFVGTISQTQLDRRLARLIGTSQFLHEAQCAPRKSSPELIIPSAYNAREYLNNFKKSTNEINLYAVASQLPKKSVDLPKQDEFSRENPEQSSNYGQPTSEALLKVYKTLQTDLPRFFVTTMDYRIYSREIEFINHIKGTATQGLNNYMKQILLLRVGGHLTYAYIKLEVLKITMHSEDSTIRVRWRIRGLSTYKAFFNFWKFKWLKSIGGIKSLESWYDGYSVFSVNAQGQIYRHVADKMMPDEEMTQDKGKPDIAAKLAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MQT7</accession>
    <name>A0A8J2MQT7_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS10603</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5101701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MQT7"/>
    <dbReference type="OrthoDB" id="25654at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5101701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="115" mass="12982" checksum="782115286ADF46E2" modified="2022-05-25" version="1">MGRQVRADDVVRSTDTTEEIQVETSDISNKFKFFETYKEPEKERKQFRITPPRDGQVKKYYVVFCKISTGIRYGATNLSNVPAAPGTTDIHIGGSKRAGYSTAPNNTSKFHPYGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MTC1</accession>
    <name>A0A8J2MTC1_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Similar to TRIP11: Thyroid receptor-interacting protein 11 (Homo sapiens)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HICCMSTLAB_LOCUS7245</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5093919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MTC1"/>
    <dbReference type="OrthoDB" id="425925at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019459">
        <property type="entry name" value="GRAB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000237">
        <property type="entry name" value="GRIP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18921">
        <property type="entry name" value="MYOSIN HEAVY CHAIN - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18921:SF2">
        <property type="entry name" value="THYROID RECEPTOR-INTERACTING PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10375">
        <property type="entry name" value="GRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50913">
        <property type="entry name" value="GRIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GRIP" evidence="5">
        <location>
            <begin position="26"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="121"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAG5093919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="176" mass="18894" checksum="AE209F7CFCCA6B18" modified="2022-05-25" version="1">MKKRLISKLNELVNTAEQRIQEAKESGIGKVDKNLVKNLLLGFISASNADKSSVLRVMATVLDFNESERDKSGLNSSNAHGGWFSGLLHGGATKDQEASLSAAFIKFLESESKPVSSVPALPISNTSIRPGHSRQHSTSSNQSGGLLLSNMTLPSFPDFIPSRNTGSILKEVLKDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MUK6</accession>
    <name>A0A8J2MUK6_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similar to CAAP1: Caspase activity and apoptosis inhibitor 1 (Bos taurus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS9847</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5100774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MUK6"/>
    <dbReference type="OrthoDB" id="10064012at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042981">
        <property type="term" value="P:regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038991">
        <property type="entry name" value="CAAP1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14740">
        <property type="entry name" value="CASPASE ACTIVITY AND APOPTOSIS INHIBITOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14740:SF3">
        <property type="entry name" value="CASPASE ACTIVITY AND APOPTOSIS INHIBITOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15335">
        <property type="entry name" value="CAAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="17"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="137"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="304"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="505"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="19"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="149"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="160"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="304"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="336"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="347"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="385"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="509"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="588"/>
            <end position="598"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5100774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="617" mass="68312" checksum="E9F8FD4A467CF25E" modified="2022-05-25" version="1">MIYSINHVTNSLMPHTFHDSSSSSCSTSSFSEDETDDKPLKPIKDYLYNRKEMSRQLFMSVKTEKIKMMLPQTLKKTDLSELEELCVNELCGMSKSRVLSILNGKQMLDSSNTSESDDSGPSLEIISDTEAWITDSELPDDKDKVSASKSRKVKTKKIKKEPTASDKQAKTNSQNKNKSARKQTADLVKVKNEKESKSQPQQGESLLDLLELEMRARAIRALIRKEEDIIPNESTTSKISVNVNSLLDQANISLAVGLGNNSTKEADKSSARSKVEEAVSLSLNSNEDEDVVLVVKPTPTINLLSSDSEAEDSNVNISKSNGEKIETSTECSLTDKNNKENQDKLSDSLNINKINQANDVNNKSSGGTNSESKDKSQDSAITKVPSDKSSELYKEKSKKINEPSKVLEESSSNSIILHDEDEIIDLDNYSDDMDEIENDKIIESSVKNNPSKVEVKFTVESNSTESSSLDSSETWATRYYQTDNVQSVIKESKIQSEIRKRLRERQKLSKLNNNSNNNGNSASKESVIKSNAVEKPIEPDNSKPTGSVEEYLALKRVSSPDVKSTVCEQNPTDVKVDNIPGEKIFPVTTENIDQSAGDESTIEQPHVSPSIPVQENS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MY95</accession>
    <name>A0A8J2MY95_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Similar to D11DS: Acyl-CoA Delta(11) desaturase (Trichoplusia ni)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">HICCMSTLAB_LOCUS12626</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="12">The histidine box domains are involved in binding the catalytic metal ions.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the fatty acid desaturase type 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5107192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MY95"/>
    <dbReference type="OrthoDB" id="10260134at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004768">
        <property type="term" value="F:stearoyl-CoA 9-desaturase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006636">
        <property type="term" value="P:unsaturated fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03505">
        <property type="entry name" value="Delta9-FADS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015876">
        <property type="entry name" value="Acyl-CoA_DS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005804">
        <property type="entry name" value="FA_desaturase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11351">
        <property type="entry name" value="ACYL-COA DESATURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11351:SF31">
        <property type="entry name" value="DESATURASE 1, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00487">
        <property type="entry name" value="FA_desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00075">
        <property type="entry name" value="FACDDSATRASE"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 12" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="8" id="KW-0408">Iron</keyword>
    <keyword evidence="3 12" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="31"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="63"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="178"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="206"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="domain" description="Fatty acid desaturase" evidence="15">
        <location>
            <begin position="65"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="307"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="310"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="321"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CAG5107192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="331" mass="38078" checksum="E31DBBF8E548A6B6" modified="2022-05-25" version="1">MAPNVTTALTALCEEDLAKSPPSKPQYKRKIVWFNVYAFCVLHATALYGMYLAFTSAKLITTFYAFILYQCGGIGVTAGAHRLWSHRAYKAKLPMKIILMIFNTLAFQNSIFEWARDHRVHHKYSETDADPHNANRGFFFAHVGWLLCKKHPDVKEKGKGIDMSDLEADPVVSFQHKYYLILMPLICFILPGIAPVYLWGESWSNAYFVGVFLRYVWTLHMTWLVNSAAHFFGHRPYDKYTNPSENLLHVFPWDYKAAELGKYWGNTTTAFIDFFTLLGWAYDTKVVSQEIIKQRVLRTGDGSHPVWGWGDKDQTPDNRESAVTTNKLHTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-10-16" modified="2023-09-13" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>S6CVS2</accession>
    <name>S6CVS2_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Cc_bv6.24_35.1a</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">bv6-24</name>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS6213</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Philos. Trans. R. Soc. Lond., B, Biol. Sci." volume="368" first="20130047" last="20130047">
            <title>Functional endogenous viral elements in the genome of the parasitoid wasp Cotesia congregata: insights into the evolutionary dynamics of bracoviruses.</title>
            <authorList>
                <person name="Bezier A."/>
                <person name="Louis F."/>
                <person name="Jancek S."/>
                <person name="Periquet G."/>
                <person name="Theze J."/>
                <person name="Gyapay G."/>
                <person name="Musset K."/>
                <person name="Lesobre J."/>
                <person name="Lenoble P."/>
                <person name="Dupuy C."/>
                <person name="Gundersen-Rindal D."/>
                <person name="Herniou E.A.Drezen.J.M."/>
            </authorList>
            <dbReference type="PubMed" id="23938757"/>
            <dbReference type="DOI" id="10.1098/rstb.2013.0047"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5092544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="HF586473">
        <property type="protein sequence ID" value="CCQ71264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S6CVS2"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5092544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCQ71264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="82" mass="9518" checksum="F63AF467D90BEE1C" modified="2013-10-16" version="1">MALKLFVPNEWKVLLPTTLQKELVSTIVTWQVTHESSQGATGAYNGVTAELIESDYDWWFRKADDRNTKPDRKCYSVFVMYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>S6D326</accession>
    <name>S6D326_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Cc_bv12.3_4.1a</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">bv12-3</name>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS1901</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Philos. Trans. R. Soc. Lond., B, Biol. Sci." volume="368" first="20130047" last="20130047">
            <title>Functional endogenous viral elements in the genome of the parasitoid wasp Cotesia congregata: insights into the evolutionary dynamics of bracoviruses.</title>
            <authorList>
                <person name="Bezier A."/>
                <person name="Louis F."/>
                <person name="Jancek S."/>
                <person name="Periquet G."/>
                <person name="Theze J."/>
                <person name="Gyapay G."/>
                <person name="Musset K."/>
                <person name="Lesobre J."/>
                <person name="Lenoble P."/>
                <person name="Dupuy C."/>
                <person name="Gundersen-Rindal D."/>
                <person name="Herniou E.A.Drezen.J.M."/>
            </authorList>
            <dbReference type="PubMed" id="23938757"/>
            <dbReference type="DOI" id="10.1098/rstb.2013.0047"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CAJNRD030001116">
        <property type="protein sequence ID" value="CAG5075866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="HF586478">
        <property type="protein sequence ID" value="CCQ71363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S6D326"/>
    <dbReference type="OrthoDB" id="8117405at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5075866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCQ71363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="210" mass="24061" checksum="C8F8642D1974AD8B" modified="2016-04-13" version="1">MNEYQALTPEIQVPKEWTVDGIKNIVEYLVQDAINCHRSGKKFVMTVGNVPAMIKDNGTKPGYVFKKIKEIKNEDTCKIDLIIPARITILKRTNIGPNDKKEEAVEYLPMNLKFDHPIAKFVSTNPDRHTVMTIVPDVEKILLLKGIVGSEKYNYTLRTTYRVHNIKWLDDTMSDMETGESTAESFIVNAHQISKNKWDIVGYNRPPQPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-10-16" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>S6D9K9</accession>
    <name>S6D9K9_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Cc_bv8.8_32.19</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">bv8-8</name>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS6196</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Philos. Trans. R. Soc. Lond., B, Biol. Sci." volume="368" first="20130047" last="20130047">
            <title>Functional endogenous viral elements in the genome of the parasitoid wasp Cotesia congregata: insights into the evolutionary dynamics of bracoviruses.</title>
            <authorList>
                <person name="Bezier A."/>
                <person name="Louis F."/>
                <person name="Jancek S."/>
                <person name="Periquet G."/>
                <person name="Theze J."/>
                <person name="Gyapay G."/>
                <person name="Musset K."/>
                <person name="Lesobre J."/>
                <person name="Lenoble P."/>
                <person name="Dupuy C."/>
                <person name="Gundersen-Rindal D."/>
                <person name="Herniou E.A.Drezen.J.M."/>
            </authorList>
            <dbReference type="PubMed" id="23938757"/>
            <dbReference type="DOI" id="10.1098/rstb.2013.0047"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5092527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="HF586473">
        <property type="protein sequence ID" value="CCQ71249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S6D9K9"/>
    <dbReference type="OrthoDB" id="7671380at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5092527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCQ71249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="138" mass="15910" checksum="0CE5620160599376" modified="2013-10-16" version="1">MEGFLYYVKLTKDIFVPSGCPLDCIDRLVLTLAEKIINENNRVNSILQVKDIPAKLVTLKNNDDFVFVFEQVSITETVGSYLYEIVIPKEEASIRRRTFSGNSFINESWPDYAISVFTKAKRISYYLMPLRLKEVTLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2E3N5</accession>
    <name>A0A8J2E3N5_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similar to Lrmda: Leucine-rich melanocyte differentiation-associated protein (Mus musculus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS2075</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001116">
        <property type="protein sequence ID" value="CAG5076094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2E3N5"/>
    <dbReference type="OrthoDB" id="272149at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043313">
        <property type="entry name" value="LRMDA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46282">
        <property type="entry name" value="LEUCINE-RICH MELANOCYTE DIFFERENTIATION-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46282:SF2">
        <property type="entry name" value="LEUCINE-RICH MELANOCYTE DIFFERENTIATION-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="213"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5076094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="260" mass="29284" checksum="8381C975C0B3D5A5" modified="2022-05-25" version="1">MAQDFNRSALTVSHNRACYTGQRSTRIPRGLIKIVGVNCVSLDLSYNELTSISALKECLCLEELILDNNKLYDLITLPVMEALTTISLNNNKLMDIDLALERISSCCPKVKHVSLLGNPGYPDQLTDPVNNDDADYDRYRLYAIHILPESLRFLDFRPVTPLERKDASNRGRFMRTIKLSITPSPSAPALHSNFNRNPNFCGFFKENVDAGASQERKDNYSPLPSTTRGPDDHKGAYGKCRYRYSGKNSEGNRFIINSDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2E8B5</accession>
    <name>A0A8J2E8B5_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Similar to Patj: Patj homolog (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS201</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001033">
        <property type="protein sequence ID" value="CAG5072962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2E8B5"/>
    <dbReference type="OrthoDB" id="6022242at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.650">
        <property type="entry name" value="L27 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5072962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="146" mass="16041" checksum="A33472E78435BD9B" modified="2022-05-25" version="1" fragment="single">MQCCLGIHGILLCFLGTLRILCIDAWVGSTTVLLRSLLIDESLGRGLAALLRHTSTIMHMLKHIGDEVKNSNTSQLQKQTVSEIELLISLIEDPVFHDIIVIFDSLNDLNNQILQHPSILPGDFIINSAGQLEVSIPNSTKSTVND</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2E970</accession>
    <name>A0A8J2E970_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS670</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001114">
        <property type="protein sequence ID" value="CAG5073898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2E970"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5073898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="100" mass="11140" checksum="CE76A8A1382191E4" modified="2022-05-25" version="1">MSQLTDLEVKQETQNVLENINEMTKKIKAEFKLINQLIDSNGQLGKLANEANQKLINQAQELGKKVTLDAEDSDEVGGNHELRSSIDAVTQKLMGIMEDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2E9W3</accession>
    <name>A0A8J2E9W3_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS114</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030000684">
        <property type="protein sequence ID" value="CAG5071965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2E9W3"/>
    <dbReference type="OrthoDB" id="7701713at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5071965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="111" mass="12971" checksum="30F59A569715D3F9" modified="2022-05-25" version="1" fragment="single">MALFEDYLDIEALEDVREISQVYVCGICEEICNSYLDHKCLKKYKNHHIDENHYCYPLLEDGVTLIRRALLENGREELITEKIYSISKENNKTSGNFQIPNSKNKKVKTKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2EAD0</accession>
    <name>A0A8J2EAD0_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="19">Ionotropic receptor 25a.2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">HICCMSTLAB_LOCUS1316</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001116">
        <property type="protein sequence ID" value="CAG5075162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2EAD0"/>
    <dbReference type="OrthoDB" id="5984008at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015276">
        <property type="term" value="F:ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038023">
        <property type="term" value="F:signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.190.10:FF:000024">
        <property type="entry name" value="Glutamate receptor, ionotropic, delta 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000143">
        <property type="entry name" value="Probable glutamate receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019594">
        <property type="entry name" value="Glu/Gly-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001508">
        <property type="entry name" value="Iono_Glu_rcpt_met"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015683">
        <property type="entry name" value="Ionotropic_Glu_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001320">
        <property type="entry name" value="Iontro_rcpt_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18966">
        <property type="entry name" value="IONOTROPIC GLUTAMATE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00060">
        <property type="entry name" value="Lig_chan"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10613">
        <property type="entry name" value="Lig_chan-Glu_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00177">
        <property type="entry name" value="NMDARECEPTOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00918">
        <property type="entry name" value="Lig_chan-Glu_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00079">
        <property type="entry name" value="PBPe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="Periplasmic binding protein-like I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="15" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0407">Ion channel</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="8 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 19" id="KW-0675">Receptor</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="495"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="795"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="domain" description="Ionotropic glutamate receptor C-terminal" evidence="17">
        <location>
            <begin position="373"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="domain" description="Ionotropic glutamate receptor L-glutamate and glycine-binding" evidence="18">
        <location>
            <begin position="383"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="452"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="457"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="709"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="site" description="Crucial to convey clamshell closure to channel opening" evidence="14">
        <location>
            <position position="601"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="721"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="19">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="19">
        <location>
            <position position="861"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR601508-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR601508-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR601508-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM00079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="SMART" id="SM00918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="CAG5075162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="861" mass="98676" checksum="557FFB502FDB982B" modified="2022-05-25" version="1" fragment="single">INDEGNELANQSIDIALTDIRAKDPTVLGNVIVVQLNESDPKEALEQVCSVWDSAVKNGTSGVPDLVLDTTRSYFSTKTVNVFAAFLGIPKISARYGQRSDVKHWKDLTVNQTNYLVQIMPPVNLIPKAFRQLDCEKNVSNVAIIFDDTYVTDRMYKGLLQNISSRHIVVQAEADNSDIEQQLDRIRDLDVVNYFVLGNESTLNNYLDVADDKNLTGCRYGIGSNQAHLRSLTAQNLLPPVWLTVAFYYDVVRIGVGAMKSAIKKKSWPTSLKPRFITCEEYNGNNTPTYNFDLLGELRNATTNKLEPTFTRFHWGENNGEHHAEFNIGVNMVVINDGNSIFSDDLGLWNVDICSPLTSKTNTTLAHYTEVPTYRIVTVERPPFMEFNKETKKWEGICIDLLEEMQKYTKFNYEIYESPDGEYGSLNDKGEWNGMIKELITDNADVALGALSVTATREYAIDFTVPYYEPVGYSVITKRQLDSTSLFVFRKSMSWKVWVCSLAAFISTSLLIYIFDRWSPYSYRNDPHNKYNRHHTRIFTLRNSFWYTMSCLGPSGGGPPPKNFSGQILACSWWGFGFITIAAYSANLAASTTVGRLQPTIKTWDQVREQFKIQYAPIKDSNAYQYFFGMKAIEESFYDIWKDISLNDSLTHRERAQYAVWDYPVDDEFSRIVSHMSEYGYPESKEDALNRMFGLPPYTNESNFALIDEATELRYWALTNCSFFLFEGEFTKKPYAIAVQQGSPIKNIFDHALIELEKSYTMKRLKEKWWDNNPKRMYNCPERINRSEGLHIGNIGGIFIVLAVGNVIGVLTVILQYWWYCLRSRTRLGQLLEDGFSLDKVKPKKFKVKPMLRKITRPDKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2EAT1</accession>
    <name>A0A8J2EAT1_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">2-oxoisovalerate dehydrogenase subunit beta, mitochondrial</fullName>
            <ecNumber evidence="3">1.2.4.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Branched-chain alpha-keto acid dehydrogenase E1 component beta chain</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HICCMSTLAB_LOCUS614</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Together with BCKDHA forms the heterotetrameric E1 subunit of the mitochondrial branched-chain alpha-ketoacid dehydrogenase (BCKD) complex. The BCKD complex catalyzes the multi-step oxidative decarboxylation of alpha-ketoacids derived from the branched-chain amino-acids valine, leucine and isoleucine producing CO2 and acyl-CoA which is subsequently utilized to produce energy. The E1 subunit catalyzes the first step with the decarboxylation of the alpha-ketoacid forming an enzyme-product intermediate. A reductive acylation mediated by the lipoylamide cofactor of E2 extracts the acyl group from the E1 active site for the next step of the reaction.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>N(6)-[(R)-lipoyl]-L-lysyl-[protein] + 3-methyl-2-oxobutanoate + H(+) = N(6)-[(R)-S(8)-2-methylpropanoyldihydrolipoyl]-L-lysyl-[protein] + CO2</text>
            <dbReference type="Rhea" id="RHEA:13457"/>
            <dbReference type="Rhea" id="RHEA-COMP:10474"/>
            <dbReference type="Rhea" id="RHEA-COMP:10497"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83142"/>
            <dbReference type="EC" id="1.2.4.4"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:13458"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="9">Heterotetramer of 2 alpha/BCKDHA and 2 beta chains/BCKDHB that forms the branched-chain alpha-keto acid decarboxylase (E1) component of the BCKD complex. The branched-chain alpha-ketoacid dehydrogenase is a large complex composed of three major building blocks E1, E2 and E3. It is organized around E2, a 24-meric cubic core composed of DBT, to which are associated 6 to 12 copies of E1, and approximately 6 copies of the dehydrogenase E3, a DLD dimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.4.4" evidence="3"/>
    <dbReference type="EMBL" id="CAJNRD030001114">
        <property type="protein sequence ID" value="CAG5073807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2EAT1"/>
    <dbReference type="OrthoDB" id="878at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003863">
        <property type="term" value="F:branched-chain 2-oxo acid dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009083">
        <property type="term" value="P:branched-chain amino acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007584">
        <property type="term" value="P:response to nutrient"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07036">
        <property type="entry name" value="TPP_PYR_E1-PDHc-beta_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.920:FF:000004">
        <property type="entry name" value="2-oxoisovalerate dehydrogenase subunit beta 1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000001">
        <property type="entry name" value="Pyruvate dehydrogenase E1 beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033248">
        <property type="entry name" value="Transketolase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42980:SF1">
        <property type="entry name" value="2-OXOISOVALERATE DEHYDROGENASE SUBUNIT BETA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42980">
        <property type="entry name" value="2-OXOISOVALERATE DEHYDROGENASE SUBUNIT BETA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02780">
        <property type="entry name" value="Transketolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="TK C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Transketolase-like pyrimidine-binding" evidence="12">
        <location>
            <begin position="48"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00051764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00057409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00063295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00071568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00082400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAG5073807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="369" mass="40552" checksum="271F315AA1682F5E" modified="2022-05-25" version="1">MIPSKLYAYNYMSLLSNLLRKKSHNSVRSLHFSFVPDKKSYDGETKKINMYQAINDALGIALEKNSNSVIFGEDVAFGGVFRCTVGLKDRFGNSRVFNTPLSEQGIVGFGIGLANQGVTAIAEIQFADYIYPAFDQLVNEAAKIRYRSGNLFDCGKLTVRAPCGAVGHGALYHSQSPEAYFAHTPGLKIVVPRGPIQAKGLLLSCIDDPDPCLIFEPKALYRIAVDDVPVNSFKVPIGKAEIVREGDSITLVGWGSQVHVLLETADIVQEKLGASCEVIDLMSILPWDIETVSTSAKKTGRVVIAHEAPLTNGFGSEIAATIQEACFLHLEAPVQRVTGWDTPFPLIFEPFYLPDKWRCFDVIKKTLNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2EBV9</accession>
    <name>A0A8J2EBV9_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS2106</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001116">
        <property type="protein sequence ID" value="CAG5076125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2EBV9"/>
    <dbReference type="OrthoDB" id="10327637at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="147"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="455"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5076125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="599" mass="69361" checksum="C3CA1944E2CF1309" modified="2022-05-25" version="1">MSYVMESSIKDQQQKPENESNLHSPMMQETIELTTNVIEKLNKNVEKKAKVEWVVKILRADFLQDRFFCIVQDGGENLFKCIIPLSLTQKFESGIISPGRCIKIKDYGVLRYACSLFKEKYTGTKNFIFVMGVVDFDIAKPTLKKVEENPPLPSTSGGKPAPLPVSRSVVPPNNPQPGRNVVPVQKTYPNLQDRPKIVPMPPPQDIVKLHSIRTIAAQMTKFLYGTLKFYPDSIKSNDALYMVISDGNRSMVCWVYGWIKNLFKKKIKDGLKIRVKNFTVRAVTIRLNRFPQYNLEMVLNSTTDFHVYDDDKPVIVHLFNESVPFKLDPNVKVITHRYRTLMDILNSHTNKSINFIGVIVDQTSVIQTTSVTVRRITVQDESGTVEVALWRRDGENFSIPTGQIIIGHNFYVDRKFRVNFTPCSNGHTLTVAPKSPDESRLREWMTSLYSNTKRPIYFGQQEDSDEEKSEKKPVQPIKRVQPIKPVQPIKSKKQKRKLEKEKKRQLKIERRRIIKETEEESFREIEMQEMKDRIAVGEELEYLQEIKKKMERMANHYIQTDGLFDLGARKDFKTWALPPEVIPAEELPRIVEKNKIKKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2ECY8</accession>
    <name>A0A8J2ECY8_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Similar to CALML4: Calmodulin-like protein 4 (Bos taurus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HICCMSTLAB_LOCUS1732</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001116">
        <property type="protein sequence ID" value="CAG5075578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2ECY8"/>
    <dbReference type="OrthoDB" id="435273at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016460">
        <property type="term" value="C:myosin II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000216">
        <property type="entry name" value="Putative calmodulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050230">
        <property type="entry name" value="CALM/Myosin/TropC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048:SF0">
        <property type="entry name" value="CALMODULIN LIKE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048">
        <property type="entry name" value="MYOSIN LIGHT CHAIN 1, 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="113"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG5075578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="180" mass="21343" checksum="ABB55F6A715E3163" modified="2022-05-25" version="1" fragment="single">KKRQLYLKKYNLQYKFYEITLLLLYTFIIIQKARYFREEDIDEFRECFYLFAQDGQIKRLEELTIIMRSLGLSPTTAELSKYMKDKNGRMSFADFLEVMHLQTRVEDLPKEVNDAFKAADQSRSGLIPARQLAHNLLNWGEKLTNKEVEQIFREANVSLNGNIKYEDFVKIACAPIPDYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2EDA0</accession>
    <name>A0A8J2EDA0_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS1998</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001116">
        <property type="protein sequence ID" value="CAG5076017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2EDA0"/>
    <dbReference type="OrthoDB" id="8191594at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20905:SF28">
        <property type="entry name" value="GH28833P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20905">
        <property type="entry name" value="N-ACETYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="693"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5076017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="693" mass="77150" checksum="5973E87E5B1D08AE" modified="2022-05-25" version="1" fragment="single">AYVSITSSNQRSVTPRPSEKIILHSSVSKTTIMSNRKRTLSYRPWGSTEDGAIEFESLTSTTLEGALNVIRESFFPEESVCLGCDIQSEPGASEELEQLCMYTAKDGVSVVAIDVKTMEVVGVAFNKLHKRLAADQRGFFEEFSENCKHKASKFLVDFMISVDAKVNLFKHYNVDCILEIMFLATKPSFQKRRIGELLVSSSLELGRQLYKGMPVKTEVEIDELPLTNADAVPSLVSAIMTSKYSQKISQKIGFDNLAEVSYDEYTFAGKKARALEVLRKSFFTFENVSTGCDLLSEPGASEELEQLNIMAAYDGVSLVAKNQDDEVVGICINKLNVHSSENQKSYLELFSEQCKYKSSKCLVDFMISMSKRQNFSERYNTNCTMDILSFATRLDYQNIGIGGNLIANAFDLGQCLSQGNDVKVSAHPDGKTITNADAIPAALTTIMTSDYSQKICVKLGFDAFAKESYDNFTFGDKVEAALEVQQKSMCDENVAIGVGLYEEENAPESMECVFREVIKDNCTIVGIDIETDDVVAVSFNKLHTKAQEDEPNFFVEIVESHIKSGPALALIQFIDEVESKVNIFEKYNASAAMEIFYIGTHPNYRGRRIGQEILGASIALAAELKDPINGSKVKPEAIFGVFTSNYSQKLAEYHHFEWLSTVDYSDFEFFGKKMSDRIKSSEHKTSKLGARSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2EDB1</accession>
    <name>A0A8J2EDB1_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Similar to DENND10P1: Putative DENN domain-containing protein 10 B (Homo sapiens)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HICCMSTLAB_LOCUS2013</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Late endosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DENND10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001116">
        <property type="protein sequence ID" value="CAG5076032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2EDB1"/>
    <dbReference type="OrthoDB" id="66409at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000641">
        <property type="term" value="P:regulation of early endosome to late endosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042431">
        <property type="entry name" value="FAM45"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037516">
        <property type="entry name" value="Tripartite_DENN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28544:SF1">
        <property type="entry name" value="DENN DOMAIN-CONTAINING PROTEIN 10-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28544">
        <property type="entry name" value="PROTEIN FAM45A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08616">
        <property type="entry name" value="SPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50211">
        <property type="entry name" value="DENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0967">Endosome</keyword>
    <keyword evidence="3" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDENN" evidence="5">
        <location>
            <begin position="1"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAG5076032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="330" mass="38198" checksum="7008C3C67A0AA3C1" modified="2022-05-25" version="1">MAPPTQLISCSIIEKDLNGDTLWTWTYPSVTDDQKTIITRKYNLQSEHCSTQSFVFSHYNNEWFYINSSEVFDTDKLPRVKQFALILFTKDYNPQKYEVLCRVLSKMYCKTGNPVEILKLYLSVFTNGSCTTEENGIYNSDDYNLSHLNSDTNIRDLIKTFELETILIYNALLLKKRIVVYHHSLEQLFKWIRTFPALMKHRDVTDNLIPWIDLNADEIQDLKSNAYYIAGCRDSAVALKPELYDLLVNIPAREITIAPHAKESFIMTKTHKEIALFMIQLCEKTSSELQITNEIADKTQDLLNQLKNIATVDDSGKKILTVQTIRNRIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2EDK4</accession>
    <name>A0A8J2EDK4_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Trafficking protein particle complex subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HICCMSTLAB_LOCUS2095</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="8">May play a role in vesicular transport from endoplasmic reticulum to Golgi.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 8">Golgi apparatus</location>
            <location evidence="1 8">cis-Golgi network</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the TRAPP small subunits family. BET3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001116">
        <property type="protein sequence ID" value="CAG5076114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2EDK4"/>
    <dbReference type="OrthoDB" id="10262857at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030008">
        <property type="term" value="C:TRAPP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048193">
        <property type="term" value="P:Golgi vesicle transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14942">
        <property type="entry name" value="TRAPPC3_bet3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1380.20:FF:000013">
        <property type="entry name" value="Trafficking protein particle complex subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1380.20">
        <property type="entry name" value="Trafficking protein particle complex subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016721">
        <property type="entry name" value="Bet3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024096">
        <property type="entry name" value="NO_sig/Golgi_transp_ligand-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007194">
        <property type="entry name" value="TRAPP_component"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13048">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04051">
        <property type="entry name" value="TRAPP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018293">
        <property type="entry name" value="TRAPP_I_complex_Bet3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111126">
        <property type="entry name" value="Ligand-binding domain in the NO signalling and Golgi transport"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 8" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="7 8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR018293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAG5076114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="181" mass="20612" checksum="21BFB796FF08D6C9" modified="2022-05-25" version="1">MKMSSRTGARLDTKKINSELFTLTYGALVAQLLKDYENVEDVNKQLERMGYNMGVRLIEDFLARTGSGRCYDFRDTAEKIQSGFKLFLGITPTITNWSAIGDEFSLCFESNPLTEFVELPDNCLHLKYCNILTGVLRGACEMVQMEIASWFVQDQLKNDNITELRVKFIKRLEDAIPAGED</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2EDW2</accession>
    <name>A0A8J2EDW2_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Similar to CANX: Calnexin (Canis lupus familiaris)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HICCMSTLAB_LOCUS2315</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Calcium-binding protein that interacts with newly synthesized monoglucosylated glycoproteins in the endoplasmic reticulum. It may act in assisting protein assembly and/or in the retention within the ER of unassembled protein subunits. It seems to play a major role in the quality control apparatus of the ER by the retention of incorrectly folded proteins. Required for embryogenesis and larval development under heat and ER stress conditions. May be important for germ cell development. Involved in neuronal necrotic cell death.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the calreticulin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001117">
        <property type="protein sequence ID" value="CAG5076898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2EDW2"/>
    <dbReference type="OrthoDB" id="1938156at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.250.10:FF:000001">
        <property type="entry name" value="Calnexin homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000011">
        <property type="entry name" value="Probable calnexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.250.10">
        <property type="entry name" value="Calreticulin/calnexin, P domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001580">
        <property type="entry name" value="Calret/calnex"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018124">
        <property type="entry name" value="Calret/calnex_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009033">
        <property type="entry name" value="Calreticulin/calnexin_P_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11073:SF1">
        <property type="entry name" value="CALNEXIN 14D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11073">
        <property type="entry name" value="CALRETICULIN AND CALNEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00262">
        <property type="entry name" value="Calreticulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00626">
        <property type="entry name" value="CALRETICULIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63887">
        <property type="entry name" value="P-domain of calnexin/calreticulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00803">
        <property type="entry name" value="CALRETICULIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00804">
        <property type="entry name" value="CALRETICULIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0143">Chaperone</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035339253" evidence="10">
        <location>
            <begin position="23"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="466"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="245"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="513"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="264"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="513"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="531"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="548"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="143"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00053392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR601580-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU362126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAG5076898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="566" mass="65209" checksum="FF98C6C7549A72D9" modified="2022-05-25" version="1">MARTRALILVLIINLFSTKIFCEESHSHDQDFSDEETKASYTSPVVSGFAYLAESFDDSERFKTVWIQSQAKKESADEDIAKYDGVWSLEESLRNQQDGDLGLVLKSKARHAAISALLNKPFKFDDKPLIVQYEVNFQEGQECGGAYLKLLTQDPAHADLKKFHDKTPYTIMFGPDKCGNDHKLHFIFRHKNPVNGTIEEKHCKKPKERLEEYFKDKIPHLYTLVIRPDNSFVIKVDNKIVNEGSLLDDFTPPVNPPLEIEDPNDTRPEDWDDREKIPDPTAVKPEDWDEDAPVQIVDEDDVVPDGWLEDESPTIPNPDAVKPEDWDVEMDGEWEPPEIPNPKCEGVAGCGPYKQKMKKNPRYKGKWLAPLIDNPNYKGKWKPRLIHNPDYFNDDHPFRMSPIHAIGFELWSMSPDIYFDNLIITDDEDVAKQWAEDTFEIHRKKIAQDSWTIWRQFVNFTSENPWIWAVYILVAGIPVLLIVYCCCFQSQNKFFFLLDDKESLNAIEEDLNEQVDPAEEDVQQESATLADADDQDNASETEEADNEKEEHTGDGDGPRRRKANKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2EFZ8</accession>
    <name>A0A8J2EFZ8_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS826</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001114">
        <property type="protein sequence ID" value="CAG5074054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2EFZ8"/>
    <dbReference type="OrthoDB" id="6578935at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5074054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="139" mass="15611" checksum="5B5C369F3AE9633F" modified="2022-05-25" version="1">MARFAYECNDDIKLNDTNYESNIRTYMCPAEKSYCLYCCCNPQDVLRNIFGKLGTSGLISTYIVSNCRYGFNLRTTSNNLQVPSLSGTRINDELNEISIHVIPTTDILLSTSHIKMQLAAPQPNAIHMSKSFNCGKKNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2EIN6</accession>
    <name>A0A8J2EIN6_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Similar to cep290: Centrosomal protein cep290 (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HICCMSTLAB_LOCUS613</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Cilium basal body</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Microtubule organizing center</location>
            <location evidence="2">Centrosome</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001114">
        <property type="protein sequence ID" value="CAG5073805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6351660at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034451">
        <property type="term" value="C:centriolar satellite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035869">
        <property type="term" value="C:ciliary transition zone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097711">
        <property type="term" value="P:ciliary basal body-plasma membrane docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905349">
        <property type="term" value="P:ciliary transition zone assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905515">
        <property type="term" value="P:non-motile cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026201">
        <property type="entry name" value="Cep290"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18879">
        <property type="entry name" value="CENTROSOMAL PROTEIN OF 290 KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18879:SF20">
        <property type="entry name" value="CENTROSOMAL PROTEIN OF 290 KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0966">Cell projection</keyword>
    <keyword evidence="4" id="KW-0970">Cilium biogenesis/degradation</keyword>
    <keyword evidence="5 8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1472"/>
            <end position="1510"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="102"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="284"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="562"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="639"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="803"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="923"/>
            <end position="950"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="985"/>
            <end position="1047"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="1215"/>
            <end position="1242"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="1280"/>
            <end position="1462"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="1551"/>
            <end position="1644"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="1669"/>
            <end position="1746"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="1803"/>
            <end position="1897"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1472"/>
            <end position="1490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1500"/>
            <end position="1509"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAG5073805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="1964" mass="229455" checksum="8B1D9DC84C494BBB" modified="2022-05-25" version="1">MVQMDWDRIRGVKAVSLTDDEIEDLFPMVIGCDTEQVDNIHNLRALIKLSQEMLQYKDNQVESLVLECDELKTKISNNLTPKKSKKNNVIDNGVTQISDLNSNNYEEILRTKNEKIKTLMNELKEFEKENEELKEKLGNLKEEMEDAIESMNEMTEELNNQNGKLLLLKEEASNLKQEKAALFNQIEEMTAAQLERDKVIDEFGAAIDERVSEWKGILDSKDAEIFKLKEQLSQSLISPSTSRNVTAEIVYLNEEIDKRDKIIEELKFKLGEAAAEINDSAAVIEKLNGDLKKMEKSGKRKEQRDLLKKIQDANEKISILNSSLAESENNLMAKSQQLCEVLDSLKKYQNKNQGLTETINEVKELKKQLTAKTNHIQDLVNVVNKLEALNSRQEIQIIALREKLGMSDDEEICVEAVESRYQEEARVKNELLKHAEMLEQENLDFKSDIRALKYKLSKFSDKPIISSRDSPDKKQNQDNSSTINWTDEGFISLRRKSEYDEVQKNMKIIVEENEALRKGMHEILDSIHDQDGKSSIEIQSDILERLLETLDVRHLAGWYHPAMRLQERLNVIQGSNNELRSQLKQLRKEIQKKDNILKKVALKHDYQNSVTNSEESETEEAKVYALEMEKIQTRYENDFDEWLKEKETLTQKISDLTELKEKLETQLKIYENDLKVFGSSEDEINQAFAIRTKEFTELMTSQKITSRKIKLLESLLNDELQKMYFFKKETIASESAYKKTIADLEKGAKLLEQKVTKLEKNFVNTVSRDDFDELNKKYNQLHLRYRVLYEVQLSVNEKDFKGVEKINAELQEQLASVQTLLAEKIKSNCECESKIGDKNPFEMKEEILKLRNENNNLMKSLEISRDEAQKHYLTNSLKIFEVDNLRHQIVDLQAVSEDKETIARLGFELNTCKAVEMETNIYKAQLENEVARAKKDFEVSEEKYSEIQSRLEEHRNYCDKKSRNYELIIDFLRNQYSGSTSATSLLRYEDLVADLKRNRAEVERQLKEAKETLEKARMQQETLTNRLEIVERLKDILEQQIGSANVEDVIKTFSDNSQSTLNEYRYKRKICQLENELQVQINKLSEYEGIIVEMEIEMVSNQKAWKNFDNLGIKSPRKNLEKLTEKKSEEFPVKSLVEKSQTEKNEKVMEKKSISTQIDVCTRVIGIQTDLNFNKESKKEVELNKTANAEEKVPEFLENQLKEALTLASDRSAKLIRYESQITEYQAKINALNRSLEDKDSELIEQKRVIARKSSENIESEEATEKVTLKSTTNSLQKIISQKEETILRYQNLLKEERDEYNKATARLQEQINKLNLQIDGMKNEQDKMDQSDLINELKDTKPKFDIDSEDKIVRLTEQVSNLQADLEIASQLNERWRRLAEERLEHVDEIRSKLELQHKNELDSYRREIDKWQLETSALRQQLSDNRIKLTKGNITLTKELQERDNKIEELTVAYQQLQSEFEMIEFVHHQTPSSQQSNKFNNDSNVNHSYDRTELNRTGENPQSQGHSELDLLKKQHKSFAEKEKMYKEQIIDLKQQLSRRYMAEKSEERKTSMREAQLEKKLKSMEEELNKARVQLDREYRFQENKRIKTAEELSLWEKQKKWQGLSEKLKRELKDKEAEIKKLNVNYEKLRSIVSCMEREKWFLRSKIKAEDCGTARPDFNLRVIEDLQRECQTLRDRIKELTDRLETEDCQRLGGLLEQQKRRIAALEIAAEGNLSVVDQLEALEAAKSALEKKNIKLESENFELHMEIEKVSNDTPRLKEKVEHLEKYVQLLKIEKSPDSSACSSEKDHEQSSKKSALELERTIFVLKRIVEKLQAENKRLRVNSKNSNRVVNNRGVAKTVFKGDGNGNGKRKDEEMAVLKRQYEEAKKRVIALETDLQLAEQRIKMLEDMHKEDTSVEINILKQQLAHKSELLDKVKQLLTRAAINEKALRQRIHQIEMKQTLSTIPECQLPSPTQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2EIZ0</accession>
    <name>A0A8J2EIZ0_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Similar to Nfkb2: Nuclear factor NF-kappa-B p100 subunit (Mus musculus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HICCMSTLAB_LOCUS824</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001114">
        <property type="protein sequence ID" value="CAG5074052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2EIZ0"/>
    <dbReference type="OrthoDB" id="7667736at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051070">
        <property type="entry name" value="NF-kappa-B_inhibitor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46680">
        <property type="entry name" value="NF-KAPPA-B INHIBITOR ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46680:SF3">
        <property type="entry name" value="NF-KAPPA-B INHIBITOR CACTUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="95"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="389"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAG5074052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="429" mass="49086" checksum="426F4A816BC640EB" modified="2022-05-25" version="1">MGFSGSEKGLEVEEHNMHAAIYNYSLAVYGAISNHLIGRISSFLEDKIIKNEPLETTGPFAGYTALHIACMDRDRKLVEVLVQNYHANVNAVADDGAQPIHFACLFKCVTIIKILLKAGANVDAEIEQQLFGKYIRKKRWRNDFGDKMTLSTFSILYGHSASFVSSLIEGKANFKVKSLKNKTLLMYAIEEENGIASSLIQKVQDQEWINARDSDGYAATHYRLHPKNLENDRYFDNGRIWFDDMNSAILIRNSLDAGADVNATINDDPNTLLINLAARIHFPLTLDKLLPYHYNTSQSTALYYVLRPLKTPQTQFSIDRKSASIKLILKDLIYRRTFGLFVPEDEIILMDKNTFPNSSMSSFAKEFIRNPNFPSYSMDLLKADYFFFRKQISIRIKKTSRRLEQLEALKRVENLRNAIPLPYELAFYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2EKL6</accession>
    <name>A0A8J2EKL6_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS2044</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001116">
        <property type="protein sequence ID" value="CAG5076063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2EKL6"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5076063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="82" mass="9588" checksum="2C10198590471335" modified="2022-05-25" version="1">MAEYSLVYGEKDKENSRRAVALEAGYRFDGICRRPLNDILAYEFKRPKKGFAILFADFLTQELIDKVNDANFPNPNWRIGWN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2ENT2</accession>
    <name>A0A8J2ENT2_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Similar to RPP21: Ribonuclease P protein subunit p21 (Macaca mulatta)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HICCMSTLAB_LOCUS1920</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the eukaryotic/archaeal RNase P protein component 4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001116">
        <property type="protein sequence ID" value="CAG5075904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2ENT2"/>
    <dbReference type="OrthoDB" id="128536at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005655">
        <property type="term" value="C:nucleolar ribonuclease P complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.50.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007175">
        <property type="entry name" value="Rpr2/Snm1/Rpp21"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14742:SF0">
        <property type="entry name" value="RIBONUCLEASE P PROTEIN SUBUNIT P21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14742">
        <property type="entry name" value="RIBONUCLEASE P SUBUNIT P21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04032">
        <property type="entry name" value="Rpr2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="330"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="52"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAG5075904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="356" mass="40002" checksum="9819B27B80B1FC85" modified="2022-05-25" version="1" fragment="single">MSIISLKKLGRVIDDQLEKLERTWETPHMLLSNTEAPNEEAQGLIESFLVSINKVHDELNELVEEQKESTADVDRFNETLVSESSILKDDELEQRTQNLSLLDDEIAFHNFKNYSAPVGNVSDYDYEDDSNQELGDKENAEKLKPTCIPTPVIRLLTRVKDQDVNLTPSRKNNIGCEKKDVLERMNYLYQASKLVSKHDTITASCFGNAMISCSRKAVLRIETDLKRSICKCCQSPLIPGETSRVRLITKPIKAVKTTCLICKTSKKIPTKPGYKLWTENPDSINQIFNYTPKIKQSHSLPAEVPQNGGQNKMAASNIEINIANPKIEQSDSLPEAEPQNGGQNKMAAGEINIEVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2GZW5</accession>
    <name>A0A8J2GZW5_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS1205</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001116">
        <property type="protein sequence ID" value="CAG5075000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2GZW5"/>
    <dbReference type="OrthoDB" id="10258440at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="47"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5075000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="115" mass="13293" checksum="1EC51E6BB961FD0E" modified="2022-05-25" version="1" fragment="single">SVSTRESGFYHCVSRNISNHSKFYVHTVELIVQKNDYYWESQFEVNLLRTLMVIMVIVVSIAVYLLVTTRKRDELRPTNYCKDIPKIKLSSSRSDGPGTSGFSKGYKPFHEDELP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2GZZ8</accession>
    <name>A0A8J2GZZ8_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS1322</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001116">
        <property type="protein sequence ID" value="CAG5075168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2GZZ8"/>
    <dbReference type="OrthoDB" id="10023262at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5075168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="258" mass="30267" checksum="D7A24AAD72B33574" modified="2022-05-25" version="1">MGKTAGNPIYKQKFRNEWLQDIQCKDWIVRKETSPGEFVASCKFCMCVVSKNNKYSDLKNHIETKKHKERQNICSPMRQKTLPVIKKSIEKTKVCEAYISLFIAEHTSIATVDHLGQMMKKAVNDSDTIRDIHLHRTNPYLGSGFELKIIELKEKKAITEQQEKELRERCIKFLIKLVHELRSRLPDNIQILQKTNLLACQNVLKNHQFCKSYTLCCKDRPLLYQTANLTIKKIVLENLKCKKSIPSFRINYCHERLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H3M3</accession>
    <name>A0A8J2H3M3_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS1356</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001116">
        <property type="protein sequence ID" value="CAG5075202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H3M3"/>
    <dbReference type="OrthoDB" id="124789at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="129"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="146"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="181"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5075202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="336" mass="38963" checksum="C23E4126E208656B" modified="2022-05-25" version="1" fragment="single">IETFFLGHCVRGIKKNSPKENHDNKQYCPLELRIRMNGQKDAFVVKEWNHHHNHDPPKKCKDWINGNQKKGKGKGQKKERTLEEEIIENYLDTLRKNLNSSMDTLKEKLKLLKECGKKIAELDGDGKDLHFINIDSEDDDGKKSEESEDEKEEEEMSDSNEQMTEIDKENDQNHKRKGEKRKLNQNKERVKENKKNKGEGNEKEEEEKKREDKDEGQTESGEKEIFKEMEGKKGEEKDEGQTELGETEIYKESGGSNLSDMENMVTLKNMLENLVGQEITARCEAGYIVSKEDLREMNEGLLEFLRENATIVEGLENMVEPEVLKHLNFLIHNGAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H5F8</accession>
    <name>A0A8J2H5F8_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to cc_ptp.z_17.3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS1886</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001116">
        <property type="protein sequence ID" value="CAG5075837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H5F8"/>
    <dbReference type="OrthoDB" id="6407541at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009653">
        <property type="term" value="P:anatomical structure morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048666">
        <property type="term" value="P:neuron development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00047">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050348">
        <property type="entry name" value="Protein-Tyr_Phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000242">
        <property type="entry name" value="PTP_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19134">
        <property type="entry name" value="RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19134:SF449">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00102">
        <property type="entry name" value="Y_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00700">
        <property type="entry name" value="PRTYPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00194">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50055">
        <property type="entry name" value="TYR_PHOSPHATASE_PTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="1">
        <location>
            <begin position="27"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="2">
        <location>
            <begin position="194"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5075837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="296" mass="34314" checksum="8A2179049B093326" modified="2022-05-25" version="1">MAVNSAVDINGNDFLSFINKPDLLTRIIKEYYALVPKHKEEGNSASAQNENKCKKELGMHLTRYLNRRIKLRNDGRVLDASFVDGYDFERKYICIKRLQEDACDKFWQAVSNYKVQIIVLISRLSDKKCYQYWSSKEGCVKVSDKFRIKTLKIIIKPHFNLTLLSLTDKFGQEQKISHYQYTAWPGDNFSHKPDAFIDFYCNVKDMCLQLERQTADKKIAPIIVQCLDGIGSSAVFCVFDICATQFDKTGTLSLPSVLKKVRQQKYGFMNCLDDYVLCYQLLAVYVKEKLFMLPFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H5H8</accession>
    <name>A0A8J2H5H8_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS5990</name>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS815</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001114">
        <property type="protein sequence ID" value="CAG5074043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5092232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H5H8"/>
    <dbReference type="OrthoDB" id="6423981at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5074043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5092232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="75" mass="8375" checksum="7453FE44FFEBD355" modified="2022-05-25" version="1">MRSGLPKPFQSTSLSQIFNHQLTSTAMEGAVGLTVNRRSDFDPSEPIYTDPSLFEVSRDSLHQSNSARNENLHLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H5V9</accession>
    <name>A0A8J2H5V9_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="21">Axonemal (Mus musculus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">HICCMSTLAB_LOCUS2387</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="16">Force generating protein of eukaryotic cilia and flagella. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP.</text>
    </comment>
    <comment type="subunit">
        <text evidence="17">Consists of at least 3 heavy chains (alpha, beta and gamma), 2 intermediate chains and 8 light chains.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium</location>
            <location evidence="1">Flagellum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Cilium axoneme</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the dynein heavy chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001117">
        <property type="protein sequence ID" value="CAG5077159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="286107at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097729">
        <property type="term" value="C:9+2 motile cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036156">
        <property type="term" value="C:inner dynein arm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045505">
        <property type="term" value="F:dynein intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051959">
        <property type="term" value="F:dynein light intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008569">
        <property type="term" value="F:minus-end-directed microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060294">
        <property type="term" value="P:cilium movement involved in cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036159">
        <property type="term" value="P:inner dynein arm assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="entry name" value="Axonemal dynein heavy chain 8"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Dynein axonemal heavy chain 5"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Dynein axonemal heavy chain 5"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Dynein axonemal heavy chain 5"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Dynein axonemal heavy chain 5"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Dynein axonemal heavy chain 5"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Dynein heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Dynein heavy chain 2, axonemal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.920.20:FF:000001">
        <property type="entry name" value="dynein heavy chain 2, axonemal"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Dynein heavy chain 5, axonemal"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Dynein, axonemal, heavy chain 5"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Dynein, axonemal, heavy chain 5"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Dynein, axonemal, heavy chain 5"/>
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        <property type="entry name" value="Dynein, axonemal, heavy chain 5"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.1220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.100">
        <property type="entry name" value="Dynein heavy chain, N-terminal domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.180.20">
        <property type="entry name" value="Dynein heavy chain, N-terminal domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="5"/>
    </dbReference>
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        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035699">
        <property type="entry name" value="AAA_6"/>
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    <dbReference type="InterPro" id="IPR035706">
        <property type="entry name" value="AAA_9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026983">
        <property type="entry name" value="DHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041589">
        <property type="entry name" value="DNAH3_AAA_lid_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042222">
        <property type="entry name" value="Dynein_2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043157">
        <property type="entry name" value="Dynein_AAA1S"/>
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    <dbReference type="InterPro" id="IPR041466">
        <property type="entry name" value="Dynein_AAA5_ext"/>
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    <dbReference type="InterPro" id="IPR024743">
        <property type="entry name" value="Dynein_HC_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024317">
        <property type="entry name" value="Dynein_heavy_chain_D4_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004273">
        <property type="entry name" value="Dynein_heavy_D6_P-loop"/>
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    <dbReference type="InterPro" id="IPR013602">
        <property type="entry name" value="Dynein_heavy_linker"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013594">
        <property type="entry name" value="Dynein_heavy_tail"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042228">
        <property type="entry name" value="Dynein_linker_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46532:SF4">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46532">
        <property type="entry name" value="MALE FERTILITY FACTOR KL5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12774">
        <property type="entry name" value="AAA_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12775">
        <property type="entry name" value="AAA_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12780">
        <property type="entry name" value="AAA_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12781">
        <property type="entry name" value="AAA_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17857">
        <property type="entry name" value="AAA_lid_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08385">
        <property type="entry name" value="DHC_N1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08393">
        <property type="entry name" value="DHC_N2"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF17852">
        <property type="entry name" value="Dynein_AAA_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03028">
        <property type="entry name" value="Dynein_heavy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12777">
        <property type="entry name" value="MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="15" id="KW-0966">Cell projection</keyword>
    <keyword evidence="12" id="KW-0969">Cilium</keyword>
    <keyword evidence="11 18" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="14" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="10" id="KW-0243">Dynein</keyword>
    <keyword evidence="9" id="KW-0282">Flagellum</keyword>
    <keyword evidence="19" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0493">Microtubule</keyword>
    <keyword evidence="13" id="KW-0505">Motor protein</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="19" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="4110"/>
            <end position="4132"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="20">
        <location>
            <begin position="1937"/>
            <end position="2081"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="20">
        <location>
            <begin position="2216"/>
            <end position="2371"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="20">
        <location>
            <begin position="2541"/>
            <end position="2689"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="18">
        <location>
            <begin position="1290"/>
            <end position="1343"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="18">
        <location>
            <begin position="3165"/>
            <end position="3238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00058146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00065818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="CAG5077159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="4142" mass="477645" checksum="E46F6442F93B4C30" modified="2022-05-25" version="1">[encoded data, 4142 characters]</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H648</accession>
    <name>A0A8J2H648_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Similar to ACP20: Adult-specific cuticular protein ACP-20 (Tenebrio molitor)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HICCMSTLAB_LOCUS2610</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001117">
        <property type="protein sequence ID" value="CAG5077985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H648"/>
    <dbReference type="OrthoDB" id="6382835at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042302">
        <property type="term" value="F:structural constituent of cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031311">
        <property type="entry name" value="CHIT_BIND_RR_consensus"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000618">
        <property type="entry name" value="Insect_cuticle"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051217">
        <property type="entry name" value="Insect_Cuticle_Struc_Prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12236:SF95">
        <property type="entry name" value="CUTICULAR PROTEIN 76BD, ISOFORM C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12236">
        <property type="entry name" value="STRUCTURAL CONTITUENT OF CUTICLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00379">
        <property type="entry name" value="Chitin_bind_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00947">
        <property type="entry name" value="CUTICLE"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00233">
        <property type="entry name" value="CHIT_BIND_RR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51155">
        <property type="entry name" value="CHIT_BIND_RR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0193">Cuticle</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035218772" evidence="3">
        <location>
            <begin position="20"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG5077985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="176" mass="19257" checksum="EBD362A7F8F2B8C1" modified="2022-05-25" version="1">MFKLFVLAALAVASEASYADYDGYVNSNVGYGSYYGLGHGHDGSYQTFVAPVVADAHYQHGVYGHGYDGHDYEGHNVYDHGLNHHDTYAPAKYAFNYGVNDPHTGDVKSQEEVREGDVVKGSYRLNEPDGTIRIVEYTADPHNGFNAVVKKIGHAVHPAPVPVVKYVAPAYAHHGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H675</accession>
    <name>A0A8J2H675_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS2665</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001117">
        <property type="protein sequence ID" value="CAG5078176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H675"/>
    <dbReference type="OrthoDB" id="7698113at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="42"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5078176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="119" mass="13461" checksum="8041D9C4EE1F42EB" modified="2022-05-25" version="1">MDNLTKIVELLVNVQKEQNLPKNPPEKPITTDVVQKAESSKENNPNKNNVSETSNTGQAENNEKAEQETDKDGVLKVLGLDPDDSKIKNVKYHPELKNTWLKWKSEGLPEKNKKEILEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H686</accession>
    <name>A0A8J2H686_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Sidoreflexin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HICCMSTLAB_LOCUS2687</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Mitochondrion membrane</location>
            <topology evidence="1 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the sideroflexin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001117">
        <property type="protein sequence ID" value="CAG5078248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H686"/>
    <dbReference type="OrthoDB" id="6608471at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015075">
        <property type="term" value="F:monoatomic ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140300">
        <property type="term" value="P:serine import into mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004686">
        <property type="entry name" value="Mtc"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00798">
        <property type="entry name" value="mtc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11153">
        <property type="entry name" value="SIDEROFLEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11153:SF8">
        <property type="entry name" value="SIDEROFLEXIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03820">
        <property type="entry name" value="SFXNs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="88"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="137"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="211"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="253"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU362000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAG5078248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="308" mass="34061" checksum="4F59E9EA83E0C6F4" modified="2022-05-25" version="1">MSGSKIQRIDLEKPRWDQSTYLGRAKHFFNLTNPLNVFAKGESLESLKITEDELWKNKYLYDSAYHPDTGEKMLVIGRMSAQVPMNMFITGCMLTFYKSTPAVVFWQWFNQSFNAVVNYTNRSGASPIPTETLVRSYVGAVGGAVITALSLNRLARRAPPLAGRLVPLAAVAAANCVNIPLMRITELQEGIELQNEEGAKLGNSKKAAREAIASVTMSRILMASPSMVLSPILMNFLDRRNMLAKAKWAAAPIQLVVCGVCLTFATPLCCALFAQRVPVSIDHLEPEVQEAIRAKNPTVNMLYYNKGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H6H8</accession>
    <name>A0A8J2H6H8_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Similar to Ipo5: Importin-5 (Mus musculus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HICCMSTLAB_LOCUS2853</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001117">
        <property type="protein sequence ID" value="CAG5078833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H6H8"/>
    <dbReference type="OrthoDB" id="543373at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000357">
        <property type="entry name" value="HEAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040122">
        <property type="entry name" value="Importin_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041653">
        <property type="entry name" value="Importin_rep_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040928">
        <property type="entry name" value="Importin_rep_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041389">
        <property type="entry name" value="Importin_rep_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034085">
        <property type="entry name" value="TOG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057672">
        <property type="entry name" value="TPR_IPO4/5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10527">
        <property type="entry name" value="IMPORTIN BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02985">
        <property type="entry name" value="HEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13513">
        <property type="entry name" value="HEAT_EZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18808">
        <property type="entry name" value="Importin_rep_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18816">
        <property type="entry name" value="Importin_rep_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18829">
        <property type="entry name" value="Importin_rep_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25780">
        <property type="entry name" value="TPR_IPO5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01349">
        <property type="entry name" value="TOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="TOG" evidence="8">
        <location>
            <begin position="354"/>
            <end position="594"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAG5078833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="993" mass="112007" checksum="2D4357676A52E5F9" modified="2022-05-25" version="1">MAADHEQFNQLLSTLLSTDNDVRTQAEEAYKNLPIQSKVTWLLNSICTGHLAEEIRAMAAVLLRRLFSSEFMDFYPQLPPEAQDELKKQLLLSIQNEQSETIRRKICEVVAEVARNLVDDDGNNQWPEFLNFLFQCANSPMPALKESALRIFTSVPGVFGSQQTNYLTLIKQMLQQSVMDTANYEVQYQAVRAIGAFIILHDKETSIQKQFAELLPALVQVTAQSVEKQEDEALLKVLIDLAETTPKFLRNQLETIMEMCMKIFSNKDMGDSWRQLSLEVLVTLSETAPAMVRKVGGKYIVALVPLVLEMMTDLEDDDEWSFSDEIIEEDNDCNNVVAESALDRLSCGLGGKTMLPQIVDNIPRMLSNSDWKYRHAALMAISAVGEGCHKQMEAILSQIMEGIVQYLQDPHPRVRYAACNAIGQMSTDFAPTFEQKFHEKVIPGLLMVLDDNANPRVQAHAGAALVNFSEDCPKNILTPYLDAIMGKLESILTAKFQELVEKGTKLVLEQVVTTIASVADTCEEQFVTYYDRLMPCLKYIIQNANQQEHKMLRGKTIECVSLIGLAVGTEKFINDASDVMDMLLTTHAEGELADDDPQIKVALLDNEDMEGVEGDLDWQFVSLGEQQNFGIKTAGLEDKASACEMLVCYARELKEGFADYAEEVVRLMVPMLKFYFHDGVRTAAAQSLPCLLECARIKESDVLLELLYSLAKCIELLGTGCLDPAQMTELLRILDKLLNEHFDRAVARLEKRKDEDYDEVVEEQLRDEDNEDVYTLNKVADILHALFATHKETFFPYFDQICHHFVKLLAPERSWSDHQWALCVFDDVVEFGGPASFKYQEYFLRPMISYVCDPSAEVRQAAAYGCGVFAQFGGDAYAQACAEALPRLVEVITQPEARSQENVNPTENAISAVTKILKYNSKMVNVDEMLPHWLSWLPVTEDEDEAPHVYGYLCDLIEANHPVVLGPNNEHLPRLIFYFAEAFLKEASNEVNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H6Y3</accession>
    <name>A0A8J2H6Y3_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similar to RLBP1: Retinaldehyde-binding protein 1 (Gallus gallus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS3145</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5080935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H6Y3"/>
    <dbReference type="OrthoDB" id="1434354at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902936">
        <property type="term" value="F:phosphatidylinositol bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.20">
        <property type="entry name" value="N-terminal domain of phosphatidylinositol transfer protein sec14p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036273">
        <property type="entry name" value="CRAL/TRIO_N_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10174">
        <property type="entry name" value="ALPHA-TOCOPHEROL TRANSFER PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10174:SF208">
        <property type="entry name" value="CRAL-TRIO DOMAIN-CONTAINING PROTEIN DDB_G0278031"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00650">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00180">
        <property type="entry name" value="CRETINALDHBP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46938">
        <property type="entry name" value="CRAL/TRIO N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRAL-TRIO" evidence="1">
        <location>
            <begin position="103"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5080935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="222" mass="26122" checksum="A39DA830DEDAC667" modified="2022-05-25" version="1">MDDEIDYKCSLSEETQAIALENLREDDNISRNQTIRAWILKHPSIKRCRTDPLFLLQFLRTKKFSLPIGQPMLERYLHARQLSSEWFQNLDIYDQEIEALIDNGYIFPLLERDQYGRQVILINTARADPYRFGSKEIIRAYSILGELLMDIEENQVRGYTYVHILTGATIAHGTVWSLSDMRNFFKWMKNVSPIRNKQINIVSVPNHIRKVLDFIINNNVCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H739</accession>
    <name>A0A8J2H739_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Similar to cyc: Protein cycle (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HICCMSTLAB_LOCUS3103</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5080786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H739"/>
    <dbReference type="OrthoDB" id="71302at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd19726">
        <property type="entry name" value="bHLH-PAS_cycle_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050933">
        <property type="entry name" value="Circadian_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001067">
        <property type="entry name" value="Nuc_translocat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013767">
        <property type="entry name" value="PAS_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23042">
        <property type="entry name" value="CIRCADIAN PROTEIN CLOCK/ARNT/BMAL/PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00989">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14598">
        <property type="entry name" value="PAS_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00785">
        <property type="entry name" value="NCTRNSLOCATR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="PYP-like sensor domain (PAS domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="9">
        <location>
            <begin position="341"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="8">
        <location>
            <begin position="412"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="8">
        <location>
            <begin position="630"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="114"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="162"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="271"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="766"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="164"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="182"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="274"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAG5080786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="867" mass="96679" checksum="956405E964F7F5DE" modified="2022-05-25" version="1">MVVEKSQSSGVTGNSVQLSQVPRLYSGGDIDIGIKKDINNKDSKECNIELSELDEFLHCRGCNDNNREMVGQDMAQSYNELFHAAQEPQEFISLEELGPRITTDHHCHQTVANPGINSDQLYGDTDEGQHQSHPRTYYNLSSLPDSCASVYFGDIRNGNNGIQAGEPLAPTATPATGTLSPERLDRHSSIKGPANERKNNVNTTTTTTVVQAITVSVATNISNSSSTNCSVRDVKISRVDGTLGPEYNQNCIEPFTHPDSCAMQTVLSPSQSHSYHHHHHHHHRHHHHHHHHRDILDSHCNTPEDDCLPLTKKRKVSCQDENDLIEDTIDNNKSLRINADSKKQNHSEIEKRRRDKMNTYITELSAMIPMCHAMSRKLDKLTVLRMAVQHIKTILGAVTTYTEGHYKPAFLSEQELKTLILQAADGFLFVVGCDRGKILYVSESVSEILNYSQEDLLGQSWFDILHPKDVAKVKEQLSSSDLSPRERLIDARTMLPVKTDVPHDVSRLCPGARRSFFCRMKRKIVENSSGCSESQIKEETDPAIGCHRRKKQQSTDWKYCVIQCTGYLKSWGPAKLCVEEQEGESDGEAGNLSCLVAIGRVQPSLPALTSNSSRTPRLRTIEFVSRHATDGKFLFVDQRATIVLGFLPQELLGTSMYEYYHHEDIPHLAESHKAALKSSERVTTQVYRFKAKGASIVRLQSEWRSFENPWTKDVEYLIAKNSAVCIDSQENNRYESSSNVQENYDFYTQSNASLGRLISSQVEISTAASSERDRDSTQSSIGNEANDLTPFNNVLPNVSLNMTHDQGTSSEKNMLEMMGDTTISDTPNPLTTDGSDEAAMAVIMSLLEADAGLGGPVDFSGLPWPLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H743</accession>
    <name>A0A8J2H743_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">60S ribosomal protein L7a</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HICCMSTLAB_LOCUS3255</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the ribosome.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eL8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5081338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H743"/>
    <dbReference type="OrthoDB" id="29563at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050257">
        <property type="entry name" value="eL8/uL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="Ribosomal_eL30-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004037">
        <property type="entry name" value="Ribosomal_eL8-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004038">
        <property type="entry name" value="Ribosomal_eL8/eL30/eS12/Gad45"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018492">
        <property type="entry name" value="Ribosomal_eL8/Nhp2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001921">
        <property type="entry name" value="Ribosomal_eL8_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23105">
        <property type="entry name" value="RIBOSOMAL PROTEIN L7AE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01248">
        <property type="entry name" value="Ribosomal_L7Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00881">
        <property type="entry name" value="L7ARS6FAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00882">
        <property type="entry name" value="RIBOSOMALL7A"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="L30e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01082">
        <property type="entry name" value="RIBOSOMAL_L7AE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal protein eL8/eL30/eS12/Gadd45" evidence="5">
        <location>
            <begin position="112"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAG5081338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="257" mass="29177" checksum="A36438358BD75221" modified="2022-05-25" version="1">MVQKKPKKKTGKKVAAAPLAVKKVEPKKVTNPLFEKRTRNFGIGQDIQPSRDLSRFVKWPKYIRIQRQRAVLYKRLKLFKILEKYRPESVLAKKLRLKARAEEKVAKKEDTPTKRPNMLRSGSNAVTTLVEQKKAQLVVIAHDVDPIEIVLFLPALCRKMGVPYCIVKGKSRLGRLVRRKTCTAVALTQVDSADRANFAKVVEAIKTNFNDRYDEIRRHWGGGLLGSKSAARIAKLEKAKAKELAQKQILISTQINS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H7J6</accession>
    <name>A0A8J2H7J6_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Similar to TSC1: Hamartin (Homo sapiens)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HICCMSTLAB_LOCUS3542</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5082367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H7J6"/>
    <dbReference type="OrthoDB" id="6022054at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033596">
        <property type="term" value="C:TSC1-TSC2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008285">
        <property type="term" value="P:negative regulation of cell population proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032007">
        <property type="term" value="P:negative regulation of TOR signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051726">
        <property type="term" value="P:regulation of cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007483">
        <property type="entry name" value="Hamartin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15154">
        <property type="entry name" value="HAMARTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15154:SF2">
        <property type="entry name" value="HAMARTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04388">
        <property type="entry name" value="Hamartin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="129"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="323"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="578"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="705"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="853"/>
            <end position="933"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="344"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="381"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="587"/>
            <end position="613"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG5082367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="1038" mass="117847" checksum="31238B3B2F04598B" modified="2022-05-25" version="1">MGSNSEVEKLFDLLESNKLSEVEKIKKIFHDHFLSNKDNCLVNGLLDYFFSTNSLRAIEVLAGVREPHDKHLLDRLTDTLAKPVRPSQRVQALLVLGHIARRQPTWLYKLTNHSLFRELLKLLKNEVDALLIVSALLLLVTLLPMLPAALGPYLNEIFDVFNRLASYYYTHSNSQNNLSDKVSFYLLHLHVGLYNFFHRLYAMYPCNLISYLRTHHAQRDHEYLATFKHTIKPMLDSVRMHPLLITASRDTETSPARWKQMEHHDVVAECGHFAFDRREEIYAPNNLRATPLPDQQCPLTPINIVGDPLGTKMNNDLEEDMLWSPSMKIPPNSPKSIQTMTYEPRSAPSTPNNSTSRSNSSPPEAAIEATPETTPVKDIRQTSTRSTSVGSAAVRALSAFGNGSLTGSSRPATPISNINALSFIPVMEKEGIVSQKISKLLADRNSTVQQINIEGVKKILETSSSQNGRNDSWKEDQEVVEIVNCQNPQVHHVEPYRNRDDCLRLASKNLIKKFNLCKFDSPCQSTAPVTCPKTYPNVKIRRSKSCSDIKDEKKHETSIQTDDLFPYERLLNGVVDQRGNDQQTSRNSNSNNNNNNNNNNNNNNNNNNNNYNNPDSRLSPTLMLDRYIENCASVLSIKDKKVRSFNKKKGLDDDNSDNTNEDSFIDIESVNQQLQLMQMQLLFERQRREVHAERNRRLLGKLRDSRTLQEQKTELADRLRIMESEVEGLKNEIERSKRESRITETDYKKAVDNWQSKCLEEYNRNRKLTENLEVLELEMKKEKTKVAECEQQTRVAEAAFFDAAHQLKDALKAASRSDELKRILDNVQKKFLLLGEAQTKYHERSSGPVPILRQEAAQMHRSYEEELATLKRQLDSRTSTIDALRTRLAELEHRETHIEAQLIDQQRILQETKERHEAELRAVESKYEAQVNINLSLESRILELHRNLEVANCGEINAVAAAGSSNSNNIAYSASPPLSGSLASSSEGSIAFHTSTGIMSDCCDSAGEIANLQAIVEPVPQSSSQATTPVRTTSQRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H802</accession>
    <name>A0A8J2H802_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">PRKC apoptosis WT1 regulator protein-like</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS3735</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5083116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H802"/>
    <dbReference type="OrthoDB" id="6286739at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043065">
        <property type="term" value="P:positive regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026117">
        <property type="entry name" value="Par-4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15093:SF1">
        <property type="entry name" value="PRKC APOPTOSIS WT1 REGULATOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15093">
        <property type="entry name" value="PROSTATE APOPTOSIS RESPONSE PROTEIN PAR-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="81"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="145"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="19"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="103"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5083116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="204" mass="23377" checksum="14BC924FFADF315D" modified="2022-05-25" version="1">MENEQVPTADAQVVGKQQRDRRKLREKRRSTGVVHLPSTESTGGSTGEDEEELVGTCVETKNNTQHNEFLEHELVEERTAKVYTQRRNKSHSDLEADDEEFDSLNQSDSVNQSDHGHHSHHANQLNSMNRDHIPTPTDDNPQDLLERAQKENRRLITLLENQDQKIMALEAQLLQQQREMAIERDRLRDENAALIRAMAALASN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H856</accession>
    <name>A0A8J2H856_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Similar to TMEM50A: Transmembrane protein 50A (Homo sapiens)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HICCMSTLAB_LOCUS3955</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0220 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5083872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H856"/>
    <dbReference type="OrthoDB" id="268928at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007919">
        <property type="entry name" value="UPF0220"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13180">
        <property type="entry name" value="SMALL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05255">
        <property type="entry name" value="UPF0220"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="25"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="54"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="95"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="128"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAG5083872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="155" mass="17093" checksum="D765A9EDEC4CCAFC" modified="2022-05-25" version="1">MTSCLENVQIPSCVWFEAGDNRNSIMSMLAGTLFFTGWWFIIDAHAQYPEEMSSAYHVCGVFGTISLFMVNSVTNSQIQSYASNGGCLGVRGARGWLFVGLVMGFAAVIAACWILFADFVAKDVKHSWPGVGLLLQNLFIFFGSLTYKFGRSEDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H8Q0</accession>
    <name>A0A8J2H8Q0_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Titin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">HICCMSTLAB_LOCUS3203</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5081145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2152335at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030018">
        <property type="term" value="C:Z disc"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009653">
        <property type="term" value="P:anatomical structure morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007517">
        <property type="term" value="P:muscle organ development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050793">
        <property type="term" value="P:regulation of developmental process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051239">
        <property type="term" value="P:regulation of multicellular organismal process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009888">
        <property type="term" value="P:tissue development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <location>
            <begin position="6082"/>
            <end position="6094"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="6108"/>
            <end position="6198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="6230"/>
            <end position="6258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="6295"/>
            <end position="6304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="6333"/>
            <end position="6350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="6509"/>
            <end position="6518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="6526"/>
            <end position="6536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="6602"/>
            <end position="6619"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="6694"/>
            <end position="6704"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="6730"/>
            <end position="6742"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="18">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="18">
        <location>
            <position position="8525"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00073138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="CAG5081145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="8525" mass="971519" checksum="019003BB5B3486F0" modified="2022-05-25" version="1" fragment="single">[encoded data, 8525 characters]</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H8Y3</accession>
    <name>A0A8J2H8Y3_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS4213</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5084846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H8Y3"/>
    <dbReference type="OrthoDB" id="8963429at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd10442">
        <property type="entry name" value="GIY-YIG_PLEs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21301">
        <property type="entry name" value="REVERSE TRANSCRIPTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21301:SF10">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5084846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="285" mass="32987" checksum="5A2E65C247496E2E" modified="2022-05-25" version="1">MPVINNFEVNVRNSAELVEFLHSVRLPENYVLVSLDVVSLFTNVPNMPKDNLIELVKMCFDTSYFTFQNDYYIQLDGSAMGNPASPSLANLMMNHVLRKVRFKALHMNDNGVNKIKTQGNRFRFPFVKGLSHGTSSSFRFTDWRPAFYNIRTIGDIYSKLKDITPLGQASELVYKIPCSCGKSYVGQTRQYLSKRLHQHRYSCEEKFRSKEDRTALANHHFLTGHNFDFDGVKIVDREGNWFKRNISEMVHICLSDTVNWRTNTDRLSKVYIGLIEKYEGNRNSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H9U6</accession>
    <name>A0A8J2H9U6_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Mitochondrial (Bos taurus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS3570</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5082465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H9U6"/>
    <dbReference type="OrthoDB" id="283424at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019349">
        <property type="entry name" value="Ribosomal_mS35_mit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039848">
        <property type="entry name" value="Ribosomal_mS35_mt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13490">
        <property type="entry name" value="MITOCHONDRIAL 28S RIBOSOMAL PROTEIN S28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13490:SF0">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN MS35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10213">
        <property type="entry name" value="MRP-S28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Small ribosomal subunit protein mS35 mitochondrial conserved" evidence="1">
        <location>
            <begin position="173"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5082465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="334" mass="38609" checksum="2A731075BADC488F" modified="2022-05-25" version="1">MAVFCIAERCSISAFIKISGVRYNSSSTASKTASTTQGEFRVLQLIPKKEEVKRYERNTAAIPPRSEQMPVDQDWPSVWPGPRTFHPAVVPLPIRQGYPNKNEAPPSKWGNAELMKIPNFLHLTPPAIQRHCEALKQFCTKWPKELDTNEKCDQHFPIEYISSEYCYSSPTIKDPLARIVTMRVKVSSLKLDTHARDKFLRLVGPRYDEKTDYVTIVTDRCPTRKQNRDYADYILTALYQESWVMEPWEAEKALADMEYYDWDKNKSRNTLVSIHAWPNNPPEDLDYQKIPNATEYKMAVTDLINTGEDHFTVNKYRESVKNLLHLKKSQGSSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HA06</accession>
    <name>A0A8J2HA06_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">cGMP-dependent protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">HICCMSTLAB_LOCUS5364</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.12"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cGMP subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.12" evidence="2"/>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5089754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HA06"/>
    <dbReference type="OrthoDB" id="63267at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004692">
        <property type="term" value="F:cGMP-dependent protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002374">
        <property type="entry name" value="cGMP_dep_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24353:SF144">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24353">
        <property type="entry name" value="CYCLIC NUCLEOTIDE-DEPENDENT PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000559">
        <property type="entry name" value="cGMP-dep_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="cAMP-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 11 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="14">
        <location>
            <begin position="84"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="14">
        <location>
            <begin position="202"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="348"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="15">
        <location>
            <begin position="527"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10">
        <location>
            <position position="472"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11 12">
        <location>
            <position position="378"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000559-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000559-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CAG5089754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="577" mass="66520" checksum="202F1D99BED46633" modified="2022-05-25" version="1">MKFLCCRSSLCQSKWNFDLTNKNSKAANNKNDNNEQQIYRRLSNVRRDDIFGEQVRVSSSTPIVYQKDTETKSRLRSAIKSNEFLSNFNDMQVDTIISAMYSQDIPPNTRLINEGDDAYHLYVSEEGVFDIYKGNKYQGTFGPGVVFGELALLYKAKRFASIDVKKGGKVWVLDRKSYQASMKDDIERITEDNIEMLRKISFLRDLSNHVLRKISDLMYVKFFPAGTYILDEGDTNDKFFIINCGHVKVMKLSDGQEIVISELYKGEYFGEKTLYANENNIRKASVASFVAASPGVECLIIDRKTFLNYLGDLESIKKRDWTAEYEERKKSLKIKWKPEYPDLQLTDLDINAGIGRGSFGLVLLVTSKSIPDKSFVLKKISKTLVSKLNYQKYILNEKFVMQACDSPFICKLYQTFKDPKYVYLLMEACLGGDVRTMLYRNGKFNNTTARFVTGCIIEALDHLHSLDIISRDLKPDNILLDNYGYAKLSDFGTSKRTGPYKTWSFVGTSEYMAPELILIEGHDRWFKMFDWKSLRTRIMRSPLETKISSHLDIKNFEKFPVERENTANDLSGWDADF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HAB1</accession>
    <name>A0A8J2HAB1_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS5557</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5090254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HAB1"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5090254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="68" mass="8268" checksum="51B469C9463C7DEF" modified="2022-05-25" version="1">MKKRKLKGTDVFLDNKQTEREIETEVEKKATEYAEQVYIEWGNKKEVKEEIEWSKIRYNIRCSKLSKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HAE6</accession>
    <name>A0A8J2HAE6_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS3996</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5084034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HAE6"/>
    <dbReference type="OrthoDB" id="10401638at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035214333" description="Secreted protein" evidence="2">
        <location>
            <begin position="26"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5084034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="110" mass="12776" checksum="3947B13B056B6F6E" modified="2022-05-25" version="1">MFKIQESKTVFLFIILIVLIIYCNAHPQPQTSSNDIHKNDNIEQRVKRESDENPENPNLIQELTSTEELPFLVSLIRHLIPGVNPTIVTVIYNFVVKVFKHIRDNAHNNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HAR1</accession>
    <name>A0A8J2HAR1_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS5920</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5092108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HAR1"/>
    <dbReference type="OrthoDB" id="7701706at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="141"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="284"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="361"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="145"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="176"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="371"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5092108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="437" mass="47500" checksum="87DD0C03AAC6FDAB" modified="2022-05-25" version="1">MLIITNCLADLLRLKCAKKAGKLRRKGVARASREGLKISDATALDLRAQSQAHPDFVGLEQQHHHQQQHQVQSPDHITHHQNRHLLQQHHHHLANHAGDSGGGLGGGGPGPGISPGLTVDPNSVSIQNQVAVAAAAIEEARRLQEEDEDITEREDEEEDEEPSSPEPDLEPDQEPMEVQASANSQQQSSPAPTTPSPHQREHQGTISSSMAQSLHNLAQAQAQAQAQQTMSQASSPSLTVQAVQAAQALNQNLGQALSQALSQNMQQNLGQTLQHNLQSLSPQQQMNQLNQPQNLSQSQNLQQSLQQNQAQNLSQSLQQQAQNLSQNLQGLNQQALQQQAQNLSQSLNQQSLQQQAINMAGMNQNGGVPGMNVQNQQNSQNSMMSPGTGSQDSHDATLTEKLVNELQSKNRKIANFRSLKFKKNSVGAKIIISSLRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HB30</accession>
    <name>A0A8J2HB30_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Cc_bv8.6_15.4b_pseudo</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS6180</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5092511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HB30"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5092511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="69" mass="8042" checksum="EFC221E12459B92A" modified="2022-05-25" version="1">MFSRKYLTSKILYSIVVTVNDNQEEDKTLFVFHFRELADAFRCDTALPKDLYSVKINFASGNQSCNELR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HB54</accession>
    <name>A0A8J2HB54_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS5604</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5090367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HB54"/>
    <dbReference type="OrthoDB" id="10631247at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5090367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="82" mass="9622" checksum="74DC7DC5B1A8895A" modified="2022-05-25" version="1">MIEIISSKVVSTGTSKYFSSYIESCLQTHIKLFPGKMISKHHFLIHYPRIFEEVGVISQFPVYGMKRNIRNTKYRLVVQKIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HBC8</accession>
    <name>A0A8J2HBC8_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Similar to Chymotrypsin inhibitor (Apis mellifera)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HICCMSTLAB_LOCUS4814</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the serine protease inhibitor-like (TIL domain-containing) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5088365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HBC8"/>
    <dbReference type="OrthoDB" id="6236007at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030414">
        <property type="term" value="F:peptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19941">
        <property type="entry name" value="TIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036084">
        <property type="entry name" value="Ser_inhib-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051368">
        <property type="entry name" value="SerProtInhib-TIL_Domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002919">
        <property type="entry name" value="TIL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23259:SF70">
        <property type="entry name" value="ACCESSORY GLAND PROTEIN ACP62F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23259">
        <property type="entry name" value="RIDDLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01826">
        <property type="entry name" value="TIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57567">
        <property type="entry name" value="Serine protease inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0646">Protease inhibitor</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TIL" evidence="4">
        <location>
            <begin position="48"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAG5088365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="116" mass="12730" checksum="4B98B221458E7ADA" modified="2022-05-25" version="1">MGIVFGGPSCHYVSGYLRNSSGNCVKVEDCPKPSREVNPSDKYSENECGPIEHLVKNNPSCEPTCSHPRLVICSRVRFGGSGCYCIEGYLRNSNGKCVKVEDCPNIKRGDIIFPDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HBP1</accession>
    <name>A0A8J2HBP1_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Similar to CycB3: G2/mitotic-specific cyclin-B3 (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HICCMSTLAB_LOCUS4199</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the cyclin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5084788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HBP1"/>
    <dbReference type="OrthoDB" id="5590282at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044772">
        <property type="term" value="P:mitotic cell cycle phase transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20508">
        <property type="entry name" value="CYCLIN_CCNB3_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000001">
        <property type="entry name" value="G2/mitotic-specific cyclin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039361">
        <property type="entry name" value="Cyclin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046965">
        <property type="entry name" value="Cyclin_A/B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004367">
        <property type="entry name" value="Cyclin_C-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10177">
        <property type="entry name" value="CYCLINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02984">
        <property type="entry name" value="Cyclin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001771">
        <property type="entry name" value="Cyclin_A_B_D_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01332">
        <property type="entry name" value="Cyclin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1" id="KW-0132">Cell division</keyword>
    <keyword evidence="2 4" id="KW-0195">Cyclin</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin-like" evidence="5">
        <location>
            <begin position="281"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin C-terminal" evidence="6">
        <location>
            <begin position="374"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin-like" evidence="5">
        <location>
            <begin position="378"/>
            <end position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAG5084788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="488" mass="55803" checksum="80A083DBC92BA118" modified="2022-05-25" version="1">MAPSKAINSQNKPVMMVNAVKKSITTRNQKAADQMNIKPLVTAKDLRFKRKADASPLKDKMIKRSALGNITNAIGKSLGVQLADPKKVVKKTQAKPVSSTYTLRNTEKVIVKPIAVIDKPSSKLKNVSKVTRTTKKLEVKKGIPQKSENQKPIDVEKSNDSSLYVSALEDLSQGNDKKIELNIDRIEEETIIQKIGKSKRTSVNTPAKQSVEYLDKTPVRQLPPGVLWDFDVENWRDPYQVSQYAMEIFEYLKSRERNFLIGDYMEKQVCLSRWMRSLLVDWMVEVQESFELNHETLYLAIKLVDLYLTKVTVGKETLQLLGAASLFIASKFDERIPPMIEDFLYICDGAYSQRELIRMEMNVLKIVDFDLGIPLSYRFLRRYARCIKISMPTLTLARYILEYSLMDYATIMFSDSKLASAALFLALQMKDLGGWTPTLEYYTGYTIDDIKHIVNLLNQGLHKKNKDALSTVRNKYSHNHSGVDYLER</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HBP8</accession>
    <name>A0A8J2HBP8_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS6486</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5092967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HBP8"/>
    <dbReference type="OrthoDB" id="504708at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39069">
        <property type="entry name" value="ECDYSONE-INDUCIBLE GENE E1, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39069:SF8">
        <property type="entry name" value="FI17111P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5092967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="510" mass="57931" checksum="AC298EC68862370F" modified="2022-05-25" version="1" fragment="single">IMKIICLNTNLHAYYSIVVQKKICIDRDYQRRQNYPRSGFSDIKCVETFLDGKCDNDYDCMKIKHSECSINNVCSCKNNYVQFNKTTCGIPIWGPCSKNEDCTVINSRCKDNVCQCKPGDVSKLPNNTVCTLRLDKFCITDIHCEDNSVCVDNLCQYKFFSERQWNNKRAKNLGQNCTIDQECLHNSHAECSIDKICVCGENYHEFNETLCLPLLGGFCSNDEDCYFVDNSYCRDRECRCRLHYESLLNDQCLALYLNQACKYDSDCDRIENSTCSKDKKCVCQANHSAFGENQCLAHIGEFCFNTDNCVSKPVTVCINNKCQCIDKFISLQSKDNCIPIILGAPCKDHRDCNIIKNAKCSENNICVCRNNYYALDEVSCGPSINESCSNDDDCMVPSSVCIDNQCQCQQNFSAVSRFQCVKNNLLFSCKIDTDCGDPWHSKCLENKKCGCNAQSILINKSTCLPLIRGLCWADTQCITIKDSSCVDFYCQCNSNTRFIADNMCSQIFFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HCT7</accession>
    <name>A0A8J2HCT7_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Similar to Marchf2: E3 ubiquitin-protein ligase MARCHF2 (Rattus norvegicus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HICCMSTLAB_LOCUS5147</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5089215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HCT7"/>
    <dbReference type="OrthoDB" id="273089at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011016">
        <property type="entry name" value="Znf_RING-CH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46065">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE MARCH 2/3 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46065:SF3">
        <property type="entry name" value="FI20425P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12906">
        <property type="entry name" value="RINGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51292">
        <property type="entry name" value="ZF_RING_CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="64"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="105"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="RING-CH-type" evidence="11">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAG5089215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="172" mass="20526" checksum="236242DAA6BBC1CF" modified="2022-05-25" version="1">MGAIHLSCLERWLEESNRNSCELCGYQFDIERTPRYSALHSIIIWMCTKQEEQQLFVRNIRVDLIRCMIATPLTLGSTYVCIVAADFYSTNNYDNFPPARWTTYSLVAMMILVVFSYFAWIYMALQYHQRVWFYWWQKTSVVKLKHHHTSMEDVNKNLTMYRSRMSHGILPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HE34</accession>
    <name>A0A8J2HE34_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Similar to Wdr5: WD repeat-containing protein 5 (Rattus norvegicus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HICCMSTLAB_LOCUS7957</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5095936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HE34"/>
    <dbReference type="OrthoDB" id="674604at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044666">
        <property type="term" value="C:MLL3/4 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000228">
        <property type="entry name" value="COMPASS-like H3K4 histone methylase component WDR5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059122">
        <property type="entry name" value="Beta-prop_WDR5-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848:SF8">
        <property type="entry name" value="F-BOX AND WD REPEAT DOMAIN CONTAINING 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25175">
        <property type="entry name" value="Beta-prop_WDR5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002394">
        <property type="entry name" value="GN-bd_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="WDR5-like beta-propeller" evidence="5">
        <location>
            <begin position="43"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="43"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="85"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="127"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="169"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="223"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="258"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="15"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF25175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAG5095936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="359" mass="40469" checksum="1DA62489C5315211" modified="2022-05-25" version="1">MESLPSTSSCGPSSVQEPSTSASSTENSQKKPGKPNYILWNTLFGHRRAVSAVKFSPDGKWLVSSSADKTMIIWEAYTGSCKKIIQGHCFGISDVAWSSDSKRLVSASDDKTLKMWRLSTSKCLKTFEGHLHVVFCCNFNPQGDRIVSGSFDTTVKIWNVKTGKCMKTLHAHADPVTAVEYNGNGNFIISSSYDGVCRLWDAATGNNLQTLVDRDEDDIQIPISFVKFSPNSRFILATNLNSTIKLWDYARMTSQKTYTGHTNEKYCIFANISVTGEKLIVSGSEDKFVYIWNLHTQEIVQKLEGHTDVNDKQMKENYFFYDISTKRPNYYLLFCDLSLVLSGSNYIYVTELKKVYKLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HE40</accession>
    <name>A0A8J2HE40_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Similar to PPAE1: Phenoloxidase-activating enzyme 1 (Spodoptera litura)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HICCMSTLAB_LOCUS7972</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the peptidase S1 family. CLIP subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5095966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HE40"/>
    <dbReference type="OrthoDB" id="7726766at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000028">
        <property type="entry name" value="Serine protease easter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1640.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051333">
        <property type="entry name" value="CLIP_Serine_Protease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038565">
        <property type="entry name" value="CLIP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24260:SF145">
        <property type="entry name" value="FI17609P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035197012" evidence="5">
        <location>
            <begin position="18"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="6">
        <location>
            <begin position="113"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAG5095966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="351" mass="38908" checksum="BC0040CE1909DAF4" modified="2022-05-25" version="1">MFIKYLNIFILLKVINCDQGNFYPQNYQYSNTLACPDNKICIPLDYCSEMVNLLREATFPVHRFRQAVCGYVGKTTKVCCNSPRDTSNTIQNYNNDPSYSSASKSSRNCGQSFVRSNTPTLGSFPFLARVGFINLNDGSIKYSCTGTILNERTVLTTATCALASSDEYKLHSVLIGEFDTSSNPDCNQLFCAYCTQSYEVSYVVKHPNFDAKIFEHNIALLRLNSSVPFTLTAQPICYSDQQYIPIGCTALLVGWGKVSHYKESTQQQVLPIKILPTQDCNEFLSQGLSVELCGIGFQDACSGFSGSPLLIGDASGYSVVGMLSYGSQCNQQLPSVFINVQNYARWITENS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HED5</accession>
    <name>A0A8J2HED5_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Similar to pak1ip1: p21-activated protein kinase-interacting protein 1-like (Danio rerio)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HICCMSTLAB_LOCUS8087</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="3">Negatively regulates the PAK1 kinase. PAK1 is a member of the PAK kinase family, which has been shown to play a positive role in the regulation of signaling pathways involving MAPK8 and RELA. PAK1 exists as an inactive homodimer, which is activated by binding of small GTPases such as CDC42 to an N-terminal regulatory domain. PAK1IP1 also binds to the N-terminus of PAK1, and inhibits the specific activation of PAK1 by CDC42. May be involved in ribosomal large subunit assembly.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5096193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HED5"/>
    <dbReference type="OrthoDB" id="308449at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051959">
        <property type="entry name" value="PAK1-Kinase_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44675:SF1">
        <property type="entry name" value="P21-ACTIVATED PROTEIN KINASE-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44675">
        <property type="entry name" value="PAK1 INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1 4" id="KW-0853">WD repeat</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="289"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="76"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="120"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00045213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAG5096193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="319" mass="35998" checksum="C23C7F6980C96014" modified="2022-05-25" version="1">MTEDFEIIVGTYEQFLLGYKVIKEEKKYRLERSFATKDHVASIRTTSSMKHYLASGAADDCINIYDMKRRTESGKLMHHNGTVNCVSFTPDATHLVSCSSDGSIAVVRCGNWQLEKHWTSAHKNSEVNTLAIHPTGKCTLSVGTDGVLRLWNLVNGHHAYAINLVPRLKLQAKNITVLQWSPDGEKYLMAANNQLDVYSRSTAGICAEVTFDVKIVCVEFINDNVIVIGHENGTLRIYDIEEQSELLQTVGHDSRVKCLKHKGKFIVSASSSGEVKVWKYEDIPRNVRLFGFLGVPFIVLWVVYLSIQYMNIEINIRQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HEN5</accession>
    <name>A0A8J2HEN5_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Similar to Hydin: Hydrocephalus-inducing protein (Mus musculus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HICCMSTLAB_LOCUS7979</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5095979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="7610565at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005930">
        <property type="term" value="C:axoneme"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904158">
        <property type="term" value="P:axonemal central apparatus assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003341">
        <property type="term" value="P:cilium movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033305">
        <property type="entry name" value="Hydin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053879">
        <property type="entry name" value="HYDIN_VesB_CFA65-like_Ig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059041">
        <property type="entry name" value="Ig_DLEC1_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23053">
        <property type="entry name" value="DLEC1 DELETED IN LUNG AND ESOPHAGEAL CANCER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23053:SF0">
        <property type="entry name" value="HYDROCEPHALUS-INDUCING PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22544">
        <property type="entry name" value="HYDIN_VesB_CFA65-like_Ig"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23277">
        <property type="entry name" value="Ig_Dlec1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0966">Cell projection</keyword>
    <keyword evidence="4" id="KW-0969">Cilium</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Deleted in lung and esophageal cancer protein 1 Ig-like" evidence="8">
        <location>
            <begin position="207"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="HYDIN/VesB/CFA65-like Ig-like" evidence="7">
        <location>
            <begin position="309"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="domain" description="HYDIN/VesB/CFA65-like Ig-like" evidence="7">
        <location>
            <begin position="577"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="domain" description="HYDIN/VesB/CFA65-like Ig-like" evidence="7">
        <location>
            <begin position="1702"/>
            <end position="1802"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="2292"/>
            <end position="2311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF22544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF23277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAG5095979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="2511" mass="288882" checksum="EB06E96CC89E96AE" modified="2022-05-25" version="1">MAHHNKRNFMEDMRLIIHEIENIKMEPEECNVSCPPFGCPEEPCPGQFRNTEVSQNSSTYCSDKNKNLSLISTCQVPSTKPRCVQPESRVLPNYQSSVEICYPPVHTPNNSFIQNRQQYCSKSTPLNYLHQHHIFQPSHLNSISQSHKNQNSMPPILEQKSCPQSCIITLYTSEYKNFLLNHEEKKSNSSCCSTKLTFSDTKCSRTFKIVPTEIIFRQYIPGNIYNTPLTITNIDKSSHVFRLTYDKNSPFDVNAKKMLINQKLAPGMSLNYNIKFIPEEKKDYYHQLDVVTDCQTFSVPLIAIGPRALLDFPDQIWMPETAVKIPSSKIFLIQNIGNRNTAFTSFSESEYFSIEPESGMIMEKEAVQFSVNFIASNSGNFYGIIYLQYDTGELIRIDAKANAVNCNIYLNNDQLRIEDTFIGLLTNGRLKIHNDSDYLVEFQWVKYKNPETNICHKEKLTEIFGATKNTKSTEYAGLEHDICRPEVYKSIYERIYTDEMTSLLKENFTYSNNHFSITPIKGKILPRSFTNVIVDFQPTSVGNLMSTAYLEVTGRVERIPKFSFQLILRLSGVSKGPVIKFKNPIINIGDVYIFTAQNVQAICKNEGLVTGTLSYKTKLDDDNCTINVTPEQQKIRTEEFSSFNITFSSSKYGQFTEMVDFKIEESDEIITLCIRGNSILPALNFDKTHLNCGTTALGFTSKHEVTLLNDSPVSIKLNLTIPDGNEPPVTYESFTYSAPNLVSNPKEFFIKPQQFILNAKSSRNIIINFTPNVARVSNTCLKVKFDGFDSTPVTLPIVFKSEAASLEIEPSSHVVELCYINFPFTLHFTIKNKSDIEGFAYNKKQSSKNSAIFYSMSRQLWHLKSNEFKCSSVTLIATKYGRQSIEIPIITFGSLYPQILTIAYNCQGATVLSIPSELDWGEVQLLEKKSMSFKLVNYSPVPAYFKAIISNSKSPWSLSPTSGEINPLKSENITATIFMRESKQLCNSIFVSVLNSLTVTIVLKAFGIGLPIIIDPNIFPTFDMGCFFNKQKKYLSLMVTNEGNQLQKIFFSSIEIKMMESDKLITHSKKFLVEPFLIDLLPRNKQKIKCVVYSEKIGNISEEWWIYSLLPGQKMYELIGKSLFSAKFIKPLINFNKNKLSFFINIGSNSEESSEKLIDEIEVTNTSELNLQAHVSIRAPFSLLTDKNLYTQSIVVNFCHNLASSIQICFIPLINDSQYSSKIYRDMLKFEYEYPKVDEIECEAAIIYPNIIIDPDSLQFDLILGSIVEKEITLTNEGPVTAYYQFYWANENIEYLKIKSVSLTSVNSQTKLTTDEMDLQNGFQIFKRKLSEERVDNFIKLLPIDGFVPPFSKKLITCTFYTQDPLLIKAKLQCQVLKGPLISIEVEAKADTVRYHLSTKNINFGNKLIFQYHYEKFTLKNVCNIQIDYKLYILPQESQNPTRIFSINPKKGFIKSGETAVITLQYKPIIPGYVEEFFYLDIENLSPIKISMQCHGIFPQVYLPLPRANNDNLICDEYCALQYFEDLNNNKELNNKKNSSQIISEADLSRLTSNGWYVVNCYELPQIVDIKMFIERHFATEFIKKNNTPLYDYIVTYVLNLGYVVIDQLTSHSLTILNYSSCKLFIEMKQPKSQKYLSKYGITIKFENRILEPAELCVLEISINPSSKILLDKTGEIRREIFIEVAHGCTVSILIIGVITFPSLKTNTNYIDFESIFIGECKETPLLIENDGLIDCRWRIKLSDENKMSNSFYLIETEGITSPKQHIVINIHFKPHKSGYHETDLIIFIEQSCESIKIKLIGRGVERKLNISEPSIDFFANLHGSSKEHIFYIENPNVCPIEFYWEHLDKISNEENKIIRALLTYYQANEIFLPITKIAAQLPQKLYEFYYDLVDNATSRNIKKNINNLSEEFDNANNSCMTSEFKDVKESISCDETESLIYSYINNLHNQDDFWKTRKDPIKEINDDYYYYYKLLTNKICIVFHGAPFTSYQETACRAARKINLPLLNLNTEITEFIALKKSPSAIKIKEIIYQKYEVLLATVKDQLENFEFTTKINDSTHKEKIYNQEVKINKLKNEYLFNFSKPKINDLIDSLQTIPSIEELHSMDPFSCLEYKIEGINLIESIINCKKKLLDKSSIKIKKRRSKSKHEETFLDIDINLFKEILKEILESDNFRKGFVLQTLANNFIKNQVEVFSLIINHSSINVLFFVTFDNSLELYERKLMENLTDEIGEKNKTLDTSNKTFPLASNHDFEDQSVIIEKNVDPIIKNVEQNYSEKLFAVNKNHRKSDSESNIYNKQESKRKLKSPKSQSLCEPILFKLSDKEDGIKKKKKSKSVAKAFNNYNSNLKSMLRIIDNWTSASDMNDGHRWHAKFSDPWDLRVYDLIINQLLEMSDFINKLSIEQMRGPNLNSKFYRILTKTQQRKLSNSDDQVFKLYSLPNFSSSDMSGTQVEDVEPRSAMQPGEVKYFKIVFNPENIGTFRREFFLGIIGNDKIYSISVNGIVDNPIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HES7</accession>
    <name>A0A8J2HES7_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to Afmid: Kynurenine formamidase (Mus musculus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS8643</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5097309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HES7"/>
    <dbReference type="OrthoDB" id="433474at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004061">
        <property type="term" value="F:arylformamidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049492">
        <property type="entry name" value="BD-FAE-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF33">
        <property type="entry name" value="KYNURENINE FORMAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20434">
        <property type="entry name" value="BD-FAE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BD-FAE-like" evidence="2">
        <location>
            <begin position="65"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5097309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="291" mass="33172" checksum="033056E660397A60" modified="2022-05-25" version="1">MSIDLHQKLYDPSAWSKNYTEGYEEFLKISTQATIDARNSIPCKLDVSYGPTERMKYDYYGTNLPNDSRVLIFIHGGYWQEASKELAGFHIKPLVSKGIKVFNLGYNLCPQVTLNNLVTEVRSGIEEILKVCRKMGCKDVWIAGHSAGAHLAASLLYDREWLTMLKQSKQLHLIKGLILIAGIYSLEPLLTTSYNDALKLTDDEVKNLSFNELDMSKSEAINNIKVIVTVGEKDTPVFIQESKNYSKRLIEFVDQVEFVLLRDMIDHFDIVENLHDPNYSLMKIIINNIIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HEZ0</accession>
    <name>A0A8J2HEZ0_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">Casein kinase II subunit beta</fullName>
            <shortName evidence="7">CK II beta</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HICCMSTLAB_LOCUS8483</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Participates in Wnt signaling. Plays a complex role in regulating the basal catalytic activity of the alpha subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 7">Tetramer of two alpha and two beta subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the casein kinase 2 subunit beta family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5096983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HEZ0"/>
    <dbReference type="OrthoDB" id="3971593at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005956">
        <property type="term" value="C:protein kinase CK2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019887">
        <property type="term" value="F:protein kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016055">
        <property type="term" value="P:Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1820.10:FF:000001">
        <property type="entry name" value="Casein kinase II subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.20:FF:000002">
        <property type="entry name" value="Casein kinase II subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1820.10">
        <property type="entry name" value="protein kinase ck2 holoenzyme, chain C, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016149">
        <property type="entry name" value="Casein_kin_II_reg-sub_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035991">
        <property type="entry name" value="Casein_kinase_II_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000704">
        <property type="entry name" value="Casein_kinase_II_reg-sub"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11740">
        <property type="entry name" value="CASEIN KINASE II SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11740:SF0">
        <property type="entry name" value="CASEIN KINASE II SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01214">
        <property type="entry name" value="CK_II_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00472">
        <property type="entry name" value="CASNKINASEII"/>
    </dbReference>
    <dbReference type="SMART" id="SM01085">
        <property type="entry name" value="CK_II_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57798">
        <property type="entry name" value="Casein kinase II beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01101">
        <property type="entry name" value="CK2_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0879">Wnt signaling pathway</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00058642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG5096983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="220" mass="25373" checksum="249E17809E0663D4" modified="2022-05-25" version="1">MSSSEEVSWISWFCGLRGNEFFCEVDEDYIQDKFNLTGLNEQVPHYRQALDMILDLEPDDDLDDNPNQSDLIEQAAEMLYGLIHARYILTNRGIAQMIEKYQAGDFGHCPRVYCESQQMLPLGLSDVPGEAMVKSYCPKCMDVYTPKSSRHHHNDGAYFGTGFPHMLFMVHPEYRPKRATNQFVPRLYGFKIHPLAYQMQQQSAATFKAPLRALYNNGKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HFF5</accession>
    <name>A0A8J2HFF5_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Immunoglobulin V-set domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS9112</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5099544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HFF5"/>
    <dbReference type="OrthoDB" id="5969816at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032589">
        <property type="term" value="C:neuron projection membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050808">
        <property type="term" value="P:synapse organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000129">
        <property type="entry name" value="CLUMA_CG018772, isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013106">
        <property type="entry name" value="Ig_V-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037448">
        <property type="entry name" value="Zig-8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23279:SF36">
        <property type="entry name" value="DEFECTIVE PROBOSCIS EXTENSION RESPONSE 9, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23279">
        <property type="entry name" value="DEFECTIVE PROBOSCIS EXTENSION RESPONSE DPR -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07686">
        <property type="entry name" value="V-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Immunoglobulin V-set" evidence="1">
        <location>
            <begin position="14"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5099544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="89" mass="10407" checksum="EF9C7447AF724384" modified="2022-05-25" version="1">MALVNSFLVDVALQVSWVRHRDIHLLTIGRYTYTSDQRFRAIHNVHSDDWTLQIKFPQLRDSGIYECQVSTTPHMSHFVHLNVVGFINI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HFG5</accession>
    <name>A0A8J2HFG5_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to Nacalpha: Nascent polypeptide-associated complex subunit alpha (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS8851</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5097735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HFG5"/>
    <dbReference type="OrthoDB" id="3169036at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005854">
        <property type="term" value="C:nascent polypeptide-associated complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22054">
        <property type="entry name" value="NAC_NACA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.70.30:FF:000002">
        <property type="entry name" value="Nascent polypeptide-associated complex (NAC), alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.30">
        <property type="entry name" value="Nascent polypeptide-associated complex domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016641">
        <property type="entry name" value="EGD2/NACA0like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038187">
        <property type="entry name" value="NAC_A/B_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002715">
        <property type="entry name" value="Nas_poly-pep-assoc_cplx_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21713">
        <property type="entry name" value="NASCENT POLYPEPTIDE ASSOCIATED COMPLEX ALPHA SUBUNIT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01849">
        <property type="entry name" value="NAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01407">
        <property type="entry name" value="NAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51151">
        <property type="entry name" value="NAC_AB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAC-A/B" evidence="2">
        <location>
            <begin position="66"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5097735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="127" mass="13490" checksum="DEB12EFEAD652BC0" modified="2022-05-25" version="1">MPELTELDKAASSDSKVEVIPAGSGTESDSDDSIPNLEDPSAGGGSYSGTNVSGLPIDVISKAKQTRGEKKARKLMSKLGLKLVQGVNRVTIRKAKNILFVINKPDVLKNPASDTYIIFGEAKELTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HFR2</accession>
    <name>A0A8J2HFR2_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">WD repeat, SAM and U-box domain-containing protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HICCMSTLAB_LOCUS8965</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5097963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HFR2"/>
    <dbReference type="OrthoDB" id="10064100at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16655">
        <property type="entry name" value="RING-Ubox_WDSUB1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003613">
        <property type="entry name" value="Ubox_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848:SF8">
        <property type="entry name" value="F-BOX AND WD REPEAT DOMAIN CONTAINING 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04564">
        <property type="entry name" value="U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00504">
        <property type="entry name" value="Ubox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50105">
        <property type="entry name" value="SAM_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51698">
        <property type="entry name" value="U_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 4" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="39"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="82"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="246"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="288"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="373"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="435"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="478"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="520"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="652"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="695"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="domain" description="SAM" evidence="5">
        <location>
            <begin position="752"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="domain" description="U-box" evidence="6">
        <location>
            <begin position="829"/>
            <end position="903"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00020894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAG5097963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="904" mass="100055" checksum="27F92B5B5A91AB3B" modified="2022-05-25" version="1">MKDDRYFRVVVVSHNTDKSVRVWKWHQGTGYEQVSWSPLMGHKYGVTCVKISPQSTMLASASIDGTTQLWNLRTGSKIHTLVQTGGEAVRVCRFAPDSTLLVTAGDNGQICLWDLIRRNLIRSLQAHEGSVQCVTFSPDSNWLLTSCTLGVLKLFSSFEMVDTSGSQSLDQSVNVFATVDDAHDLGVVCCDFSSYQLITNQVAIEKSYQLVTCGNDHDVKLWDVKVVEGKTQTQPINASIMLSKVFQRHSCALTCVKFSSNGAYIVSSGLDKIAVIWDTNTGKIVSVLRDHKRYVACCAFSRDGNLLATGSNDRSIIVWDLTGNNLTLDSKLLRRTAALIHQSSEENQDAVQEQKVVHFAENSGNDVTLVSTLDDHGGAVNGVAFYGNNLLASGSGDKLVRLWTAEREEEIVDTEDGEQIAHVELKFVEKPFSPIDGHKYSVNYIEFSPCGTMLASCSLDGTTMLWCTETGEQARESFVNSGTGIRVCRWSPDGTKLATAGDDEKTTLWDINTMEEIQILEGHADAITAIAFTSDSSYIVTACSEGSWRIFEIYGDSNAIVVCDAHDLGVQGCDFSPATSSPFTAVVGSRHSPTVRDDDRKSFTLATCGNDSYVKLWQIKINPKNNKDSNFCEDAEEGSYASLVSYREKRVLSGHGGNVMDVKFAPFHGEIIGSVATDRTARIWSVNSGMCLFVLEYHESLVTCCAFSGDTALFATGALDKTVALWRLPQQLISQSILIDQLRNNRKNIIDWKTEDIIKWLIEVDLGILEGRVAASRLNGRLLLTLPEEVLIARLGVFDYPDLMKLFKNQLYWLKQQDINTFNNFEDTEVPDEYVCPITHEIMREPVKCSDGFIYEKAAINEWFLCGKYTSPMTNASLSDTSITPAIALRNAICTFLHGERSDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HHX7</accession>
    <name>A0A8J2HHX7_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS9571</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5100472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HHX7"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035329011" evidence="1">
        <location>
            <begin position="19"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5100472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="85" mass="9693" checksum="55FDCDD48740D594" modified="2022-05-25" version="1">MCKLVLILLILTIRLSLSFSMNDSNCEGKKDSYELKLNKDDLDVVKFAEDGWNKLVAEGRTRGVNSRGNLYVNCVRVQVIDTERK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HI21</accession>
    <name>A0A8J2HI21_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ubiquitin-like-conjugating enzyme ATG3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Autophagy-related protein 3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HICCMSTLAB_LOCUS8686</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATG3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5097395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HI21"/>
    <dbReference type="OrthoDB" id="1584384at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000407">
        <property type="term" value="C:phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019776">
        <property type="term" value="F:Atg8-family ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061723">
        <property type="term" value="P:glycophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044804">
        <property type="term" value="P:nucleophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1460.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007135">
        <property type="entry name" value="Atg3/Atg10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12866">
        <property type="entry name" value="UBIQUITIN-LIKE-CONJUGATING ENZYME ATG3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12866:SF2">
        <property type="entry name" value="UBIQUITIN-LIKE-CONJUGATING ENZYME ATG3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03987">
        <property type="entry name" value="Autophagy_act_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0072">Autophagy</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <keyword evidence="6" id="KW-0833">Ubl conjugation pathway</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00034553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAG5097395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="158" mass="18089" checksum="BCBE7F593F6E253F" modified="2022-05-25" version="1">MQSVINSVKGTALGVAEYLTPVLKESKFRETGVLTPEEFVAAGDHLYAAETKKPVKEKKDNFPEGEIIHTRTYDLHITYDKYYQTPRLWLFGYDENQKPLTVEEIHAEVMKKIIETVMEGGGELGVHMYLIIFLKFVQSVIPTIEYDYTQNFMLSSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HI26</accession>
    <name>A0A8J2HI26_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS8084</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5096187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HI26"/>
    <dbReference type="OrthoDB" id="7670104at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="7"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5096187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="155" mass="18393" checksum="BD2F1F4147CEF590" modified="2022-05-25" version="1">MEMPKNLEDVKKSIDSMENDVNIYNLKMEENDMKRLEIERSICETEMLIEKALHIIKTNERKNEDYYNKISKVGNDFKALSEFTSNSQKNKSVDNQLVKVKSLKKEKINYRNEFDKINYSAIDLQIKKEAILQVKKKFIQLQECSKEILSMLNEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HI28</accession>
    <name>A0A8J2HI28_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="12">ATP-binding cassette transporter subfamily C member 8</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HICCMSTLAB_LOCUS8127</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5096273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18593">
        <property type="entry name" value="ABC_6TM_MRP4_D1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03250">
        <property type="entry name" value="ABCC_MRP_domain1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd03244">
        <property type="entry name" value="ABCC_MRP_domain2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000026">
        <property type="entry name" value="Multidrug resistance-associated protein lethal(2)03659"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000014">
        <property type="entry name" value="Multidrug resistance-associated protein member 4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000163">
        <property type="entry name" value="Multidrug resistance-associated protein member 4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000482">
        <property type="entry name" value="Multidrug resistance-associated protein member 4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030240">
        <property type="entry name" value="ABCC4_TMD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF448">
        <property type="entry name" value="FI20146P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="113"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="153"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="229"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="254"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="333"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="811"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="882"/>
            <end position="902"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="908"/>
            <end position="928"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="996"/>
            <end position="1017"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1029"/>
            <end position="1047"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1397"/>
            <end position="1417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1437"/>
            <end position="1459"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1509"/>
            <end position="1531"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1537"/>
            <end position="1556"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1611"/>
            <end position="1629"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1662"/>
            <end position="1683"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="2016"/>
            <end position="2043"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="2076"/>
            <end position="2102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="2146"/>
            <end position="2168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="2174"/>
            <end position="2193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="2261"/>
            <end position="2282"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="11">
        <location>
            <begin position="126"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="455"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="11">
        <location>
            <begin position="753"/>
            <end position="1055"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="1093"/>
            <end position="1320"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="11">
        <location>
            <begin position="1401"/>
            <end position="1672"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="1724"/>
            <end position="1947"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="11">
        <location>
            <begin position="2019"/>
            <end position="2320"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="2358"/>
            <end position="2585"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1947"/>
            <end position="1970"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1956"/>
            <end position="1970"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAG5096273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="2613" mass="293620" checksum="491318CC0D358268" modified="2022-05-25" version="1">MDSKVDVELKKNPREGINLLSAFTLSWVLKIFWNGYKRELEIEDLSQPLKEHKSSLLGDNLAAAWDKEVQLYDMNTKPKKEPGKSESNVKVKHKKSKTPSLQRALTKVFGARIALYGVALAIQELVIRILQPLALAQLLRFFTTSDISKTEAYLYASGVIFCSAANVFVLHPSLLAIFHMGMKMRVACCSLIYRKSLKISRTALGETTIGQAVNLLSNDVNRFDLTPVFIHYLWISPVETVIVTYLMYKEVGVAAIIGVASLLMFIPLQGWLGKKSSIFRFKTAIRTDERVRLTNEIISGIQAIKMYAWEHPFSNLIEKARKKEMRMVKYGSYVRGVMLSFMLFSSRLSLFITMLAYVLAGNQITAEKVYMLTAYYSILRQTMTVFFPQGITTVAETLVSIKRLETFLMTEEIERNDKARKKSQLNNIYYNDDNDKDLKDEKAAEPLLPQIEGSVTLDDVHAKWLDSDNEETLKGINLNIKPGQLVVIVGQVGSGKTSLLNTILKELPAHTGTVDVCGKIAYASQEPWLFAGSVRQNILFGRPWDARKYDKVVKVCQLKRDFSLFPYGDKTIVGERGVSLSGGQRARINLARAVYSDAPLFLLDDPLSAVDAHVGKHMFEECIERYLHGKTRILVTHQIQFLSNVEKIIVMKDGVIIAEGSYNKLIQMGVDFGRLLESPQEEEEAEDTLSLGRSRKNSRHASVASFSSFMTNETTGQIQAEPEEVAEMRTKGSIGGYVYSSFFKAGGNGCVLFTVFLLTVSAQLVASGSDYFVSFWVNLEQDNNSNFTFSNLVRTSSSTPKLSDHDRNICIYIFSALTILTVVITFTRSFAFFAMCVRASERLHDTMFRSISRATMKFFNTNTSGRVLNRFSRDMGAIDESLPMTLIDCIQVGLTLIGIVVIVATANIWLLIPTIVIFSIFYGMRIIYVSTSRSVKRLEGITRSPVFNHLSATLQGLPTIRSFNAEEVLTKEFDNHQDLHSTAWYIYIASSRAFGYWLDVICLIYISLVTMSFLFMSTEDDKNYEGGDVGLAITQSIGLTGVFQWGMRQAAEVENQMTSVERVLEYTNIESEPALESLPDKKPKDDWPPRGKVEFKNVYLSYSPLEPPVLKNLNFTIEPHEKIGIVGRTGAGKSSLISALFRLADIEGNIEIDGIDTGKIGLHDFRTKISIIPQEPFLFSGTLRRNLDPFRDYPDSILWSALEDVELKEMGLESHVNEGGSNLSVGQRQLVCLARAIVRNNKILVLDEATANVDPRTDEFIQKTIRRKFADCTVLTIAHRLNTVMDSDRILVMDAGSVVEFDHPYILLGNENGYLSKMVNETGAMMIETLKNLVFKFYLEIDDLCRPLKEHKSSLLGDKLAAAWEKEVKKCNKLIDNKAEKIPSLKKVLFKVFGPRIALYGVALAVMELVLRMLQPIALARLLRFFTTSELSKTEAFLYAGGVILSSAINIFVGHPYMLAIFHMGMKMRIACCSLIYRKSLKLSRTALGETTTGQAVNLLSNDVTRFDVAAIFVHYLWISPVATIIVTYLMYQEVGVAAIIGVASLLLFIPLQGWLGKQSSTLRLRTAKRTDERVHSTNEIISGIQAIKMYAWEHPFSDLIKGIRKKEMGIIRYASFLRGVTMSFMMFATRLSLFFTILSCVLSGKQITAEKVFMVVAYYNILRQIMTIFFPIGIAQVAEALVSVKRLQTFLMYEEIELDNKNNNRSDKNSNKNENIQKDNGVVMFKNFHAKWFDEDSEDTLKRINLHIEPGQLVAIVGQVGSGKTSLLNAILKELPAHTGTVDVCGKIAYASQEPWLFAGSARQNILFGRPWDAKKYDNVVGVCQLKQDFLLLPYGDKTIVGERGVSLSGGQRARINLARAVYSDVPLFLLDDPLSAVDAHVGKHLFEECIEKYLHGKTRILVTHQIQFLTNVEKIIVMKNGAITAEGSYDKLVEMGVDFGRLLESSSEDDDENSIIGSNSRSNSRSSMTSFISSKTNEIEQNQLEPAEVEEFRSRGSIGGHVYSSYYKAGGNCCILFIIMLLFVFSQLAASGSDFFIAFWVNLEQGYSNNFSFSKLLGMSNQTTYSEDDRDICIYIFAGLTVLTVVMTLIRSFAFFELCVTASKRLHDKMFRSISRATMRFFNTNPSGRILNRFSKDIGAIDELLPMAMIDCIQITLSLVGIIVVICVTNVWLIFPTILICATFYGLRVVYVSTSRSVKRLEGITRSPVFSHLSATLQGLPTIRSFNAEEILIKEFDNHQDLHSSAWYIYIASSRAFGFWLDLVCLVYIICVTMSFLLLSDNKNNVYRGGDVGLAITQSIALTGMFQWGMRQSTEVENQMTSVERVLEYTNIESEPALESLPSKKPKDDWPTRGKIEFKKVYLSYSPLESPVLKNLNFIIEPREKIGIVGRTGAGKTSMISALFRLADIEGNIEIDAVDIGEIGLHDFRSKISIIPQEPFLFTGSLRKNLDPFEQYSDHILWSALEDVELKDMTLDEHINEEGSNLSVGQRQLVCLARAIVRNNKILVLDEATANVDPRTDEFIQKAIRRKFADCTVLTIAHRLNTVMDSDKILVMDAGSVVEFDHPYILLQNENGKLSNLIQETGTLMIEALKNVAKQNYDLREQSFATV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HJA8</accession>
    <name>A0A8J2HJA8_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Similar to Mettl6: tRNA N(3)-methylcytidine methyltransferase METTL6 (Mus musculus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HICCMSTLAB_LOCUS9020</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily. METL family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5098075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HJA8"/>
    <dbReference type="OrthoDB" id="417697at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008173">
        <property type="term" value="F:RNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026113">
        <property type="entry name" value="METTL2/6/8-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22809">
        <property type="entry name" value="METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22809:SF5">
        <property type="entry name" value="TRNA N(3)-METHYLCYTIDINE METHYLTRANSFERASE METTL6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037755">
        <property type="entry name" value="Mettl2_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG5098075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="228" mass="26856" checksum="C88B68595C2AE537" modified="2022-05-25" version="1">MEDSSSDITSGHMAKQLTPEELDKMRAQNSRLVPENRALLLEKDAKKYWDLFYKRNDTRFFKDRHWTTREFEELANRGGSIFEVGCGVGNLIYPLLEDGLNFKRIYVCDLSPRAIDFVKSHSLYNENKIKAFQTDITTDNYGVLLFRDYGLYDMAQLRFKPGNKIAENFYMRQDGTRSYYFSVEELQKIFESAGFETITCEYVHRRTVNVKEKVDVPRIFVQAKFRKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HJF3</accession>
    <name>A0A8J2HJF3_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS6750</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5093327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HJF3"/>
    <dbReference type="OrthoDB" id="7989680at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5093327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="198" mass="23510" checksum="CC831F6AA8368D9F" modified="2022-05-25" version="1">MLSTTYQAHPDIRHTNLVEYKCRMFERKCLRACLGAYRSAASNYNKFISNSTLYNLADIPRIDSHIIRLIRDYFSKLPSIENSTINNLTKFTAEDLKKRNETGMLPPQAFLPLDDKGLIQDEDNVPTIYHCKRHKAHKKIEYDADDPKFRWVDFTYSKAMPTRDKMDDHRLDDKYWWLTSESKHRKELRRRIHPSSVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HJF4</accession>
    <name>A0A8J2HJF4_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similar to Dscam2: Down syndrome cell adhesion molecule-like protein Dscam2 (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS9596</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5100522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HJF4"/>
    <dbReference type="OrthoDB" id="5969272at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ig-like" evidence="1">
        <location>
            <begin position="34"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5100522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="138" mass="14856" checksum="BFFF2BA940773631" modified="2022-05-25" version="1">MSMSWIFPVRLVRGIAVIVSSTSGHGFDAHLRGPSFLIEPPSRIEFSNSSGAWLDCAATGSPAPNIDWSTADGLPAGDVLGVRRVLRNGTLVLLPFQAAAFRQDVHSAAYRCIASNSVGRILSRDVQVRASKRIYGNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HK05</accession>
    <name>A0A8J2HK05_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similar to RPRD1A: Regulation of nuclear pre-mRNA domain-containing protein 1A (Gallus gallus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS9945</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5100872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HK05"/>
    <dbReference type="OrthoDB" id="10069473at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006569">
        <property type="entry name" value="CID_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04818">
        <property type="entry name" value="CID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00582">
        <property type="entry name" value="RPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CID" evidence="1">
        <location>
            <begin position="11"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5100872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="143" mass="16755" checksum="4770ABB2D1F2CEC5" modified="2022-05-25" version="1">MKLFCHFSEDKLREKLVSLVHMRASTASVEELYKFIVHHKQKTKLIIDTWASELYKAKPYHKLYFMVLANKIIQEAEKSAPELVLAYKKCLLMVFFHLKNSREDDYLRNGITVILKNWSELGICSDLVEAAKVVFNDLHISEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HK29</accession>
    <name>A0A8J2HK29_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Similar to gadl1: Acidic amino acid decarboxylase GADL1 (Xenopus tropicalis)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HICCMSTLAB_LOCUS9990</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7 8">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the group II decarboxylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5100917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HK29"/>
    <dbReference type="OrthoDB" id="392571at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019752">
        <property type="term" value="P:carboxylic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06450">
        <property type="entry name" value="DOPA_deC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000016">
        <property type="entry name" value="Glutamate decarboxylase like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002129">
        <property type="entry name" value="PyrdxlP-dep_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45677:SF12">
        <property type="entry name" value="BLACK, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45677">
        <property type="entry name" value="GLUTAMATE DECARBOXYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00282">
        <property type="entry name" value="Pyridoxal_deC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="6 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="5 7 8" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="7">
        <location>
            <position position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR602129-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAG5100917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="552" mass="62192" checksum="7D5FCD4981D068A5" modified="2022-05-25" version="1">MPANEGTFCEDSEQQSLEDVKELKISNGNYFSEKIAADDLKISKKQLNSMENSNVCTNGCSFSSSTYPSTPSKAIHENFLRDSFEIILQSAVFDGTSRNTKVVEWVDPESLPSLINLQLKKNGTSHEELLNLIRGVIKYSVKTGNPRFVNQLFSSVDPYGLVGQWLTDALNPSVYTYEVSPVFSLMENQVLCEMRKIIGWKDGQGDGIFCPGGSMANGYAINLARHYKFPQLKETGLSGLPRLIVFTSEDAHYSIKKLAAFLGIGTSNVYCIKVDKMGKLDVDNLEGQIVGALAENAVPLMVSATAGTTVLGVYDPIRRIHEICTKYKMWLHVDAAWGGGALMSAKHRGYLDGVELADSVTWNPHKLLAAPQQCSTLLVRHENLLQSAHSSNATYLFQKDKFYDTSFDSGDKHVQCGRRADVLKFWFMWKAKGTAGFEMHIDRVFQLSRYFADLIRDRDGWKLFQEPECTNVCFWYVPKSKRHMKDDQLTQVLHKIAPIIKEKMVKKGSMLVTYQPLHGRPNFFRLVLQSSGLNEDDMRFFVNEFEILADDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HKS0</accession>
    <name>A0A8J2HKS0_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Olfactory receptor 152</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HICCMSTLAB_LOCUS12239</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5106396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HKS0"/>
    <dbReference type="OrthoDB" id="6614360at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005549">
        <property type="term" value="F:odorant binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004984">
        <property type="term" value="F:olfactory receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004117">
        <property type="entry name" value="7tm6_olfct_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21137">
        <property type="entry name" value="ODORANT RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21137:SF35">
        <property type="entry name" value="ODORANT RECEPTOR 19A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02949">
        <property type="entry name" value="7tm_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0552">Olfaction</keyword>
    <keyword evidence="8 11" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="9" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="62"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="130"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="174"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="263"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="296"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="332"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAG5106396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="388" mass="45139" checksum="59A02D5595434E0B" modified="2022-05-25" version="1" fragment="single">MNILQSPHFQDFKVVLSLLGQWPSQSRLQRYSARFFVLFAIFSILTPKVIKFVEVMDDIDGIIACLPMIFVHLTSLTKYFNWIINTSKFDHLIFLIERDGQTLEVNQDVEIMDDWLRKIKSISTTYTTSMFGILGVFLISPAFPKVLDIINPLNESRPLLQIYETEYFVDENEYYLYILLHAYMTVPISMGVLIYFDILLGTHVYHACAMFEILRTYLKTIHVEICDEQVEVKDKSKKIIHCVRMHRTTLEFADEIDSAYSTAWFIMLITCLVGLTFTGTAVRLIIIDTLPETNEAIKYVSFCLGHAFHLYFTSFQGQLLIDNSEAVFYDTLWYRIPIFYQKLLITIMMRSMNPCRISAGKVYILAKDTFSSVMQKSMSFFTVLSSMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HL15</accession>
    <name>A0A8J2HL15_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">E3 ubiquitin-protein ligase MSL2</fullName>
            <ecNumber evidence="5">2.3.2.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Male-specific lethal-2 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">HICCMSTLAB_LOCUS7868</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="15 19">Belongs to the MSL2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="23">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="5"/>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5095758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HL15"/>
    <dbReference type="OrthoDB" id="10012174at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072487">
        <property type="term" value="C:MSL complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13122">
        <property type="entry name" value="MSL2_CXC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16522">
        <property type="entry name" value="RING-HC_MSL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000174">
        <property type="entry name" value="E3 ubiquitin-protein ligase MSL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037922">
        <property type="entry name" value="MSL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032049">
        <property type="entry name" value="Msl2-CXC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032043">
        <property type="entry name" value="Msl2_Znf-RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033467">
        <property type="entry name" value="Tesmin/TSO1-like_CXC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16048:SF3">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE MSL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16048">
        <property type="entry name" value="MSL2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16682">
        <property type="entry name" value="MSL2-CXC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16685">
        <property type="entry name" value="zf-RING_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01114">
        <property type="entry name" value="CXC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52051">
        <property type="entry name" value="CXC_MSL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="6 19" id="KW-0158">Chromosome</keyword>
    <keyword evidence="9" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14 19" id="KW-0539">Nucleus</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="11" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="12" id="KW-0862">Zinc</keyword>
    <keyword evidence="10 18" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="21">
        <location>
            <begin position="41"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="CXC MSL2-type" evidence="22">
        <location>
            <begin position="289"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="231"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="235"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="20">
        <location>
            <begin position="280"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00061593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00069328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00077415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS52051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="CAG5095758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="430" mass="46552" checksum="C9CA452532551F92" modified="2022-05-25" version="1">MNATSLYVSTCRLVLQADAEDSNSWTDLYRLVPYLRQSLSCTVCSNLLIEPHTPTETNCQHHVCRGCRGGRKKLKPSCGWCKDYDKYIENVQLRILLQCYKKLCEYLTSTNIYRSLIITVSSNASSNSAAVVGATSLIELIQEGTGFKDEFKSNAGLSKSAYSILPCVYTSTTSTQTQANTLQPTVDPLATTVPESPTIRTVSNGSSIYSVMYAGSGNKITIKRKAATSVEDTDLSQQDIDNPSRGTAGGVKCIPSSQLSYGTCSPKKSSKGSKSSTSFKKPRSSSTRSKRKGCRCGNATAIPGKLTCCGQRCPCYVESKPCIECRCRGCRNPHTADGLKIRPHIPELHNLQLQLSSPLDCDSLSSDTLSSVQQCLSTSPTTIQVLNVYSTPRLDIDNVPQNLPAALLVGEDAIVSTESEADDSDIQIDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HL39</accession>
    <name>A0A8J2HL39_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Similar to Nfil3: Nuclear factor interleukin-3-regulated protein (Rattus norvegicus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HICCMSTLAB_LOCUS10773</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bZIP family. NFIL3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5101954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HL39"/>
    <dbReference type="OrthoDB" id="6151507at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007623">
        <property type="term" value="P:circadian rhythm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14694">
        <property type="entry name" value="bZIP_NFIL3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.170:FF:000025">
        <property type="entry name" value="nuclear factor interleukin-3-regulated protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047229">
        <property type="entry name" value="NFIL3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047106">
        <property type="entry name" value="NFIL3-like_bZIP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15284:SF0">
        <property type="entry name" value="GH23983P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15284">
        <property type="entry name" value="NUCLEAR FACTOR INTERLEUKIN-3-REGULATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07716">
        <property type="entry name" value="bZIP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BZIP" evidence="7">
        <location>
            <begin position="186"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="63"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="175"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="398"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="470"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="92"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="111"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="175"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="475"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG5101954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="497" mass="55386" checksum="CFBB16C6A19AC55F" modified="2022-05-25" version="1" fragment="single">KKNKIFKPLYGVDKVDLGISAKSRFTQQLTIDVIRRQIMVAEFIARQSGSPINGETACLNSNMPASHTMAHPGQGSHGGHEAHGPMPPLTHPGHHVSQHQHQHQQHHQQQHHQQSQQQQVSQHHQAQQQQQQQQQQQQQQQTQAQEQHHHDQQVIHPENYSPNFDIRKELFSQRKQREFIPDNKKDDSYWDRRRRNNEAAKRSREKRRFNDMVLEQRVMELSKENHILKAQLDAIRDKYGICGETVISPEHVLAALPSEPAMSVKRAKLPPSAALLYARSPSPVHTSVIHQPVSGTRSPRSPAQLYVPETSAYPETETFQYPYPHPAIHFDTTSALNLSSRGRRAQSPYELSSGSGDEGATIVVSHNPAANNSLPHKLRHKSRIGDKDAASALLALHGIKQEPGPRASPPWDNEGSSDERDSGISLGAEWNGSSISAVPETETEVKSRLDRLASEVASLQSILRLGKANGDHLPQQVTNHSGSTNITSSTGPANGLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HME6</accession>
    <name>A0A8J2HME6_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS11338</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5103095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HME6"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5103095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="184" mass="20570" checksum="079471997B3CED93" modified="2022-05-25" version="1">MSATLIPLMSRVYIEKIQMKIMVPRPYKFNELIKNSNTTFTSTNQQNGDVCWLGVGDKPRSSGSDVSTEVPPIVSNGFFHSAFILITGVISLLHSGELFILMLSRRNFEKTRPLNSSSSLKNNGISSLWNWRWLDSLALTFRCFITSFTISTAAIATSDFITQSIIFGSEHCIVKITFKIICSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HN61</accession>
    <name>A0A8J2HN61_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Glucosamine 6-phosphate N-acetyltransferase</fullName>
            <ecNumber evidence="6">2.3.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HICCMSTLAB_LOCUS12474</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5 6">
            <text>D-glucosamine 6-phosphate + acetyl-CoA = N-acetyl-D-glucosamine 6-phosphate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10292"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57513"/>
            <dbReference type="ChEBI" id="CHEBI:58725"/>
            <dbReference type="EC" id="2.3.1.4"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 6">Nucleotide-sugar biosynthesis; UDP-N-acetyl-alpha-D-glucosamine biosynthesis; N-acetyl-alpha-D-glucosamine 1-phosphate from alpha-D-glucosamine 6-phosphate (route I): step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the acetyltransferase family. GNA1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.4" evidence="6"/>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5106866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HN61"/>
    <dbReference type="OrthoDB" id="10039976at2759"/>
    <dbReference type="UniPathway" id="UPA00113">
        <property type="reaction ID" value="UER00529"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004343">
        <property type="term" value="F:glucosamine 6-phosphate N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006048">
        <property type="term" value="P:UDP-N-acetylglucosamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000043">
        <property type="entry name" value="Glucosamine 6-phosphate N-acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039143">
        <property type="entry name" value="GNPNAT1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13355">
        <property type="entry name" value="GLUCOSAMINE 6-PHOSPHATE N-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13355:SF11">
        <property type="entry name" value="GLUCOSAMINE 6-PHOSPHATE N-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="7">
        <location>
            <begin position="35"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG5106866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="189" mass="21323" checksum="2DE59BF3B1E401DB" modified="2022-05-25" version="1">MNTSSNSDFAKDDELELFNSSLLTRLPNLPKENGLLVRPLRSTDYDKGFIQLLGQLTDVGNITKDQFLNRFFKMKIAGGYYVVIVEDLNGGEVVGSATLVVEQKFIHNCALKGRLEDVVVNSKYRGRHLGKLLVSTISQLSRSLQCYKLSLDCRDRLIGFYESLGFQREVGNANSLNIRFETTPEHSRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HQ00</accession>
    <name>A0A8J2HQ00_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similar to Tcf25: Transcription factor 25 (Mus musculus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS10908</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5102224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HQ00"/>
    <dbReference type="OrthoDB" id="205993at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990112">
        <property type="term" value="C:RQC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006994">
        <property type="entry name" value="TCF25/Rqc1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22684">
        <property type="entry name" value="NULP1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22684:SF0">
        <property type="entry name" value="RIBOSOME QUALITY CONTROL COMPLEX SUBUNIT TCF25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04910">
        <property type="entry name" value="Tcf25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5102224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="619" mass="70543" checksum="6109244745EAA36C" modified="2022-05-25" version="1">MSRRYLKKISSSVEIAIDENEHSNIQVSPSASISNSKKFNIFNLLDENSPNDETPENYESDESNHKDNCDENVDNSNNKSKKKRKKKKNRANAKLIAKSNLSNKTKDESDEIEKTLQEVNNLLGEPDEPSCSNSNRNSAPEGVDKTRSVLQVEFKFLSAVNELKRKCGGGNRNVLAAVVGEKSKNKNKKRYLRKTWLTSLTDRFPTEQCGLSMVIDPTIKSDGDIQHFVFVHSSSYRQVQNKFFIAVESQNPDNIVSILNAHPYHIDTLLQFAELCKLNEDLQTSAEFVERAVHCFECAFHPYFNVTTGNCRLSYKNQTNRPFFIALFKHLMFISGRACYRTSLELCKVLLSLNPEGDPLAIVLTIDLFALRAKEYQWFIDFCEAWKSSRNLTQLPNIAYSLALAHFYLGHEETANELLQDALFMFPGVLNDLLEKCSVQTDTRLLGHDHFNCVAKTTTSFALEKLQTLYVVRSCHLWKDSNILGWLENAAHAVMDKIDSGDEYAAYCKEKRSQRYQGQLPKNIRRHIVLSDLKQVTITHPGMHQDDPIFSYDPLPPVDSNNIYVRQEASTQRPSNVGSSNILSLFLSSLFPNNDPNLRAQFNQLNIRNEEREAPGEFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HQ64</accession>
    <name>A0A8J2HQ64_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">polyribonucleotide nucleotidyltransferase</fullName>
            <ecNumber evidence="2">2.7.7.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HICCMSTLAB_LOCUS12347</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the polyribonucleotide nucleotidyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.8" evidence="2"/>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5106613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HQ64"/>
    <dbReference type="OrthoDB" id="437922at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004654">
        <property type="term" value="F:polyribonucleotide nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000958">
        <property type="term" value="P:mitochondrial mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000965">
        <property type="term" value="P:mitochondrial RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09033">
        <property type="entry name" value="KH-I_PNPT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11364">
        <property type="entry name" value="RNase_PH_PNPase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.10:FF:000001">
        <property type="entry name" value="Polyribonucleotide nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.70:FF:000001">
        <property type="entry name" value="Polyribonucleotide nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.70:FF:000006">
        <property type="entry name" value="polyribonucleotide nucleotidyltransferase 1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.70">
        <property type="entry name" value="GHMP Kinase, N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001247">
        <property type="entry name" value="ExoRNase_PH_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015847">
        <property type="entry name" value="ExoRNase_PH_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036345">
        <property type="entry name" value="ExoRNase_PH_dom2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012162">
        <property type="entry name" value="PNPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027408">
        <property type="entry name" value="PNPase/RNase_PH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015848">
        <property type="entry name" value="PNPase_PH_RNA-bd_bac/org-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03591">
        <property type="entry name" value="polynuc_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF008805">
        <property type="entry name" value="PRK11824.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11252">
        <property type="entry name" value="POLYRIBONUCLEOTIDE NUCLEOTIDYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11252:SF0">
        <property type="entry name" value="POLYRIBONUCLEOTIDE NUCLEOTIDYLTRANSFERASE 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00013">
        <property type="entry name" value="KH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03726">
        <property type="entry name" value="PNPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01138">
        <property type="entry name" value="RNase_PH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03725">
        <property type="entry name" value="RNase_PH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005499">
        <property type="entry name" value="PNPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55666">
        <property type="entry name" value="Ribonuclease PH domain 2-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50084">
        <property type="entry name" value="KH_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="S1 motif" evidence="7">
        <location>
            <begin position="673"/>
            <end position="744"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG5106613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="758" mass="83906" checksum="74286A46511AAB55" modified="2022-05-25" version="1">MAYLVNLRLILNNKVRLLKNYERYRKKIQVRSVGTDWSTAEVDVPLGDGKKMVISTGKLAKMASGSAMVSSGKTSVMVTSVCKTQASSSSFMPLIVDYRLKASATGRIPTNFLRRELGSTEYEITAGRLIDRTVRPSFPKGFCYETQLITNTFMIDGENLPDVLAINAASASLALSDIPWNGPVAAVRVGFIDNDIVINPTNHELQHSSLNLIVSAANNNMLVMMDGYANMINSDDLKKSIQRGVLECQEIINAIKKLAATHGKPKRPFEEVKFDEQLLASIKSLAEIQLRNIFTDFNHDKISRDNAINNLRTSIMETMKKSVEDLNLTVVVEAFNIISKEVFRELIFETNQRCDGRKLDELRDIKCEAGHLELLHGSALFQRGQTQVSCSVTLDSLDSALKMDMVSMLTSGVKEKNFFLHYEFPPYAINEVGRAGVVGRREMGHGALAERGLRAVIPEDYPFTIRLMSEVLESNGSSSMASVCGGSLALLDAGVPISQSVAGVAIGLVTKYDKESTSISDYRILTDLLGIEDYLGDMDFKIAGPRDKITAIQADIKLAGLPVEIVEKSIDAALEAKKKILDIMDQTLATPRSDKFNLPLMDSVEVPVHLRGQFLGVGGYNLKKIYLKTGVTIQPQDDKTYSIFAPNETAMKEAKEMIDVLLKDKKTPEMYFGEIYQAKIVQVKDSGVMVILYDDMKPVFVPNSHLDQTVFAHPSARNFEVGQMIKVKYLGREAESGAIRLSSKVLRTTSSSIRSRFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HQ93</accession>
    <name>A0A8J2HQ93_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS13698</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5109062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HQ93"/>
    <dbReference type="OrthoDB" id="7663419at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035196936" evidence="1">
        <location>
            <begin position="28"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5109062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="170" mass="19374" checksum="36F7FF26F8C58BA4" modified="2022-05-25" version="1">MKLKNLFIFEAVVIALVILSFTNKVDALSKNCQRWLQTWFPIYCTSNKDCPDNLSCLIEAKECRNPCNSTSCKFTDDICLVMNHVINCTSSAKSCTEQKDCPDNLDCLEKKCRNPCDGKKCDEGKICVVQDHKDICGYINGKNNKTELDGKVSVVRSCEWWDFLCRAGWY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HRB4</accession>
    <name>A0A8J2HRB4_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DNA replication complex GINS protein PSF1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HICCMSTLAB_LOCUS13488</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Required for correct functioning of the GINS complex, a complex that plays an essential role in the initiation of DNA replication, and progression of DNA replication forks. GINS complex seems to bind preferentially to single-stranded DNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of the GINS complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the GINS1/PSF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5108852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HRB4"/>
    <dbReference type="OrthoDB" id="10252587at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000811">
        <property type="term" value="C:GINS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902983">
        <property type="term" value="P:DNA strand elongation involved in mitotic DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11710">
        <property type="entry name" value="GINS_A_psf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21696">
        <property type="entry name" value="GINS_B_Psf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1030">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021151">
        <property type="entry name" value="GINS_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036224">
        <property type="entry name" value="GINS_bundle-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005339">
        <property type="entry name" value="GINS_Psf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056783">
        <property type="entry name" value="PSF1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12914:SF2">
        <property type="entry name" value="DNA REPLICATION COMPLEX GINS PROTEIN PSF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12914">
        <property type="entry name" value="PARTNER OF SLD5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24997">
        <property type="entry name" value="PSF1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05916">
        <property type="entry name" value="Sld5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158573">
        <property type="entry name" value="GINS helical bundle-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GINS subunit" evidence="6">
        <location>
            <begin position="51"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="DNA replication complex GINS protein PSF1 C-terminal" evidence="7">
        <location>
            <begin position="144"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU368085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF05916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF24997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG5108852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="196" mass="22809" checksum="E1CBC162349F27C9" modified="2022-05-25" version="1">MFGKEALKLISELDLSEDIKPFNENSVRKVMDEMHSLYNANLEDVNMTVSESDDSTSPFMSVQLRHVALHRNKRCLLAYVYNRMRRLRQARWEFGSILPREISTNMLSLETEWFKAYNKSLATYMRSIGDNQGLNLTVDMVPPKSLFIEVRCLIDYGRFELDDGQVIMLKENTHHLLPRAQCEPLVRQGILEHVNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HRM6</accession>
    <name>A0A8J2HRM6_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Cytochrome c oxidase assembly protein COX16 homolog, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HICCMSTLAB_LOCUS13398</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the COX16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5108760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HRM6"/>
    <dbReference type="OrthoDB" id="5516033at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020164">
        <property type="entry name" value="Cyt_c_Oxase_assmbl_COX16"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14138">
        <property type="entry name" value="COX16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG5108760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="85" mass="10278" checksum="D7B9CB04F3789CB5" modified="2022-05-25" version="1">MGSHLYYFVSVVLLDYHVLQIYKYRKVSSVRDEAKHEGLNLRKPEELTLESQYEKLKNQLDIDHWENKRIERPWEEGVEKNAEKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HRV8</accession>
    <name>A0A8J2HRV8_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Similar to IGFALS: Insulin-like growth factor-binding protein complex acid labile subunit (Papio hamadryas)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HICCMSTLAB_LOCUS13534</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5108898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HRV8"/>
    <dbReference type="OrthoDB" id="2325980at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:001164">
        <property type="entry name" value="GH01279p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050328">
        <property type="entry name" value="Dev_Immune_Receptor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24373">
        <property type="entry name" value="SLIT RELATED LEUCINE-RICH REPEAT NEURONAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24373:SF275">
        <property type="entry name" value="TIR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00019">
        <property type="entry name" value="LEURICHRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00364">
        <property type="entry name" value="LRR_BAC"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 6" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035205577" evidence="6">
        <location>
            <begin position="25"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="748"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="40"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="56"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="73"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAG5108898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="837" mass="93455" checksum="F4A3901D149F7B2F" modified="2022-05-25" version="1">MKRRGRLALLLPLSVLLIATTICASPTSIRNEITAEVEQGTTSATVKTPGKPEPTVSITERPTTTNQPDVTTRRTSSSSSLTRPIKVSHDQLHDAEDNTKELINFKNNRLQEILKRDKKVPAEDLVKLTKPVINPGDALLQEINTCSRLIDNQSFGPGIAHLLIENAGEIRLGPHALRDRDLEHIETITIVDTRVSHIDLTAFDGITYLFAVNLSRNGIIDIHPDTFENNTQLNLLTISGNPFWRDWSVTKDYLLNAPSVTEFDFSWNSMPHLPNSAFSKMPTLAYLNLKQNRLSNIDRAIFKPLSSLVELDLSGNLLTDLPSDVFEGTDLQSLKLNDNFLTSLTSVNATSLDILDVSNNRIKVIAKGDLDNVPSLEQLIISGNELKRIHQHAFSELDQLEHLDISNNKLTSFTEHHLRNSPRLEVLLMSDNPDLGSLPVFKINGLEYNTYSVYRFECANCGLVELKSGTFNAMPAIANLNLAGNKLAGLPKDLLSPLSSLRELDLSDNMIAFIPSDMLRGAVSMTKLNLAGNPLMTLQVTPFLQAPELTRLDVSRCMLKRVWTEARQHFKSLRFLSVRGNELERITVEELKATPKLSGLDISQNPLNCDAEFDGAIQWLKSHGVIPTETVRYISNLVASETEQHEPSGESVTSWSDLAKLVCEDELDKPILRPVPQKPPTRDDEPTDEAAAEISKSDLGDMKFIKTFPGHKNNPVEDVWLELDKNIEYDDYSNDQVSSGYRTWYSTAMWSVLTIGLVTLGVLLIIIQFARYMANRRGRGPVIRPPMILRQGLVDNKNCGLVYKPLQEEIATPQLPKKPSGYSRGPFHYKQIVPESS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HTX1</accession>
    <name>A0A8J2HTX1_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS13421</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5108785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HTX1"/>
    <dbReference type="OrthoDB" id="7678495at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5108785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="99" mass="11213" checksum="1790867DB2409674" modified="2022-05-25" version="1" fragment="single">YDDFIKNLCSLRASFSTPGLTRNENKESAENTNFIELSGRRLVDLKLLDDELWCKPCNQALRLRHSVNELKNGSASIFQVKCTTCGNMYPVNISAIEKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MB60</accession>
    <name>A0A8J2MB60_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">60S ribosomal protein L32</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HICCMSTLAB_LOCUS3180</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL32 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5081048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MB60"/>
    <dbReference type="OrthoDB" id="268693at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00513">
        <property type="entry name" value="Ribosomal_L32_L32e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001515">
        <property type="entry name" value="Ribosomal_eL32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018263">
        <property type="entry name" value="Ribosomal_eL32_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036351">
        <property type="entry name" value="Ribosomal_eL32_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23413">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L32 AND DNA-DIRECTED RNA POLYMERASE II, SUBUNIT N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23413:SF1">
        <property type="entry name" value="RIBOSOMAL PROTEIN L32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01655">
        <property type="entry name" value="Ribosomal_L32e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01393">
        <property type="entry name" value="Ribosomal_L32e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52042">
        <property type="entry name" value="Ribosomal protein L32e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00580">
        <property type="entry name" value="RIBOSOMAL_L32E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAG5081048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="134" mass="15903" checksum="9C178348E13FD832" modified="2022-05-25" version="1">MAIRPAYRPTIVKKRTKKFVRHQSDRYDKLKRNWRKPKGIDNRVRRRFKGQYLMPNIGYGSNAKTRHMLPTGFRKVLVHNVKELEVLMMQNRKFCAEIAHAVSSKKRKSIVERAQQLSIRVTNANARIRSEENE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MBQ7</accession>
    <name>A0A8J2MBQ7_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Similar to PGRP-LE: Peptidoglycan-recognition protein LE (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HICCMSTLAB_LOCUS3487</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the N-acetylmuramoyl-L-alanine amidase 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5082206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MBQ7"/>
    <dbReference type="OrthoDB" id="10001926at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008745">
        <property type="term" value="F:N-acetylmuramoyl-L-alanine amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045087">
        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009253">
        <property type="term" value="P:peptidoglycan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06583">
        <property type="entry name" value="PGRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.80.10">
        <property type="entry name" value="Peptidoglycan recognition protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036505">
        <property type="entry name" value="Amidase/PGRP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002502">
        <property type="entry name" value="Amidase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015510">
        <property type="entry name" value="PGRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006619">
        <property type="entry name" value="PGRP_domain_met/bac"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11022">
        <property type="entry name" value="PEPTIDOGLYCAN RECOGNITION PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11022:SF41">
        <property type="entry name" value="PEPTIDOGLYCAN-RECOGNITION PROTEIN LC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01510">
        <property type="entry name" value="Amidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00701">
        <property type="entry name" value="PGRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55846">
        <property type="entry name" value="N-acetylmuramoyl-L-alanine amidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0391">Immunity</keyword>
    <keyword evidence="2" id="KW-0399">Innate immunity</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidoglycan recognition protein family" evidence="4">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAG5082206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="107" mass="12209" checksum="5A58EFC86C1137B7" modified="2022-05-25" version="1">MESRYIGYNFLISGDGKVYIGRGWRTVGAHTIGVNKKSIGIALIGTFYDKSPNSVQLNSMKNLINFGIAFDFIDKKFKYYSEINDVRPYINDQHNISNFSEMIQNAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MFB3</accession>
    <name>A0A8J2MFB3_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Protein SERAC1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Serine active site-containing protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">HICCMSTLAB_LOCUS4655</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the SERAC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5087945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MFB3"/>
    <dbReference type="OrthoDB" id="5086500at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052374">
        <property type="entry name" value="SERAC1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48182">
        <property type="entry name" value="PROTEIN SERAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48182:SF2">
        <property type="entry name" value="PROTEIN SERAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="12" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00038024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00040991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00041701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CAG5087945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="568" mass="65185" checksum="947687F5066C42C8" modified="2022-05-25" version="1">MKHLQPWVCQQIAQMMDSRTAVALARIADSDLRLFLKPPHHWVDKKLYEVIDQLHQLLVDMDKLCQSSHSCLTQFISKKFYSFRKNLEFDHELSSIDFTATPTISWDEQLLTQCIEAIYHHTAIDHFSRDLANARGLSVLMEVKKKFNDNVDVCVLLAKIISNLSLYTELVDDIFRSGWIGVLAAWSRHKDIRLAGPAARALFNMDVDANNGEKFPRRIYLLHPMNRTRSKANVDVIFIHGLLGGIFISWRQRDPDLTLKSVDSMKNDNEDSLINIVKEYPQEFFEDLARDLQVRDWKKTGHDYEVILDDCPVSMNSLAAGPFTCPGNEICTEYQGIDLTRTECWPKDWLPKDVPSIRVIGINYDTSLSLWSLPCPIEVLKSTISERSLEFTKKLVTAGVGKRPIIWVCHSMGGLLVKQMLVEESKTGDKHHLCDNTKGIIFYSTPHRGSHVAALKQTTQMLLWPSIEVQELREESPQLLKLHQEFKTMLDKYKMEIVSFSETKPTFVSAMKVPLQIQFVLPKSADPEVGEFYEIPQDHLSICKPASKHSFLYRKVVDLLKKNLTKNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MHR4</accession>
    <name>A0A8J2MHR4_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS3400</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5081875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MHR4"/>
    <dbReference type="OrthoDB" id="8168818at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="26"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="136"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="166"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5081875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="189" mass="21983" checksum="A93F7E76794EB664" modified="2022-05-25" version="1" fragment="single">VILDDRELYKNNTYFTEHIYGDFTPFYAIIAVVSLIGGTIFILNIICCWCSPYKGYWNDRHTGNRWISSLWVVTPHKNPPLDLSELSHRIKHQIIDEKFYYPPSVVGDEEIPYPDSRLDTPLPQEYMELQKRETSACLTLFVVGVIMILIKYGPSICGRGQDSRYERKEYNEEDENSQAYAREISESVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MI57</accession>
    <name>A0A8J2MI57_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS6651</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5093182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MI57"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="124"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="198"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="332"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="148"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="211"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="263"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="346"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5093182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="355" mass="40423" checksum="551F307ABD7E0537" modified="2022-05-25" version="1">MNHLMIQRFYLKKKQDYYVSTPVNLKNQPTLVVRLSDIRKSYDSTRTDSTQSESPAPSIPSKLLEMFDSRSTESSFTSNLQKSNFLNLETNNSINNSPIQLSNNNLPENEKSTYSADVSFNEASNNSVKQNVEESQLETTQSENSKVSNNNDPDFDSDSSGVAKSNDSNKNDDSKIASINKSSSFEAIIPFHPCENVVNADKDDNYDNNNRKKIRQHSRKRHAKVLTAENSDIENSSRKVGFSKPKSSTKKRKYTSDVESDRTPTQSADQNKISRNTWLPAEINCLIKYFGRLETVQKTPNIATCQKLIRKYDALKNRTAIQVRAQVDNYRRAAERKERYRKKKNEGKSSKSLSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MIS7</accession>
    <name>A0A8J2MIS7_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Similar to SGTA: Small glutamine-rich tetratricopeptide repeat-containing protein alpha (Homo sapiens)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HICCMSTLAB_LOCUS7075</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SGT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5093749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MIS7"/>
    <dbReference type="OrthoDB" id="2335338at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072380">
        <property type="term" value="C:TRC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060090">
        <property type="term" value="F:molecular adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006620">
        <property type="term" value="P:post-translational protein targeting to endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.420">
        <property type="entry name" value="Immunoglobulin FC, subunit C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047150">
        <property type="entry name" value="SGT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032374">
        <property type="entry name" value="SGTA_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45831">
        <property type="entry name" value="LD24721P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45831:SF2">
        <property type="entry name" value="LD24721P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16546">
        <property type="entry name" value="SGTA_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00515">
        <property type="entry name" value="TPR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13414">
        <property type="entry name" value="TPR_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50293">
        <property type="entry name" value="TPR_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 4" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="SGTA homodimerisation" evidence="5">
        <location>
            <begin position="3"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="4">
        <location>
            <begin position="82"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="4">
        <location>
            <begin position="150"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF16546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAG5093749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="301" mass="33208" checksum="B6EA85AF251920D0" modified="2022-05-25" version="1">MAEKGLVASIIKFLMKQLEDGDITADSRESLEVAIQCLESAYSVQATDSPANFDLLNTYKTAVENLITLPPSEATDEEKAEAEKYKNEGNNLMGKGNVEEAIEYYSKAIKLDGHNAVYYCNRAAAYSKINNHREAIKDCKTALVIDNKYSKAYGRMGLAYSSLNEHKEAKECYEKALEIEPTNESYKNNLHLTEEKLAQQGVSNIGLGGAGNVPGFPDMSSLLSHPVLMNMARQMLADPGMQNVMTEFMSGNVESNDRMEALIQAGQQLAQQMQSANPELIDLLRRQMGGNPNDPDPPQQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MJ42</accession>
    <name>A0A8J2MJ42_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">CYP305D1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HICCMSTLAB_LOCUS4189</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5084748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MJ42"/>
    <dbReference type="OrthoDB" id="1844152at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016712">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008395">
        <property type="term" value="F:steroid hydroxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006082">
        <property type="term" value="P:organic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006805">
        <property type="term" value="P:xenobiotic metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050182">
        <property type="entry name" value="Cytochrome_P450_fam2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24300:SF376">
        <property type="entry name" value="CYTOCHROME P450 15A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24300">
        <property type="entry name" value="CYTOCHROME P450 508A4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0349">Heme</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="217"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAG5084748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="241" mass="27701" checksum="0E61E7E5EFF9F8EF" modified="2022-05-25" version="1">MFLQMLSNVLCVIVICLITILVAIYFAKSKDAPPGPYPWPIFGNLKLLRKLSKKFGGQHIAFLKLSKQYSSDVINIRLGSSNIIVVCGLESIQKILRDENYDARPWNEFVKIRNMGLKKGITMADGSEWKKMRGWLVRSLRNLGFSRDEMSKKLNDELKIILDKLKVQNNRPLRIKPIIAPAIINGIWSLVTGKRIHEEKSYYTSSISWRGEPKHSILLVECCLFFLGFDTLLLRLLVMNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MLL0</accession>
    <name>A0A8J2MLL0_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Similar to mzt1: Mitotic-spindle organizing protein 1 (Taeniopygia guttata)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HICCMSTLAB_LOCUS6469</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MOZART1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5092950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MLL0"/>
    <dbReference type="OrthoDB" id="48571at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000931">
        <property type="term" value="C:gamma-tubulin ring complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031021">
        <property type="term" value="C:interphase microtubule organizing center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005819">
        <property type="term" value="C:spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033566">
        <property type="term" value="P:gamma-tubulin complex localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051415">
        <property type="term" value="P:microtubule nucleation by interphase microtubule organizing center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090307">
        <property type="term" value="P:mitotic spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022214">
        <property type="entry name" value="MZT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28520">
        <property type="entry name" value="MITOTIC-SPINDLE ORGANIZING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28520:SF2">
        <property type="entry name" value="MITOTIC-SPINDLE ORGANIZING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12554">
        <property type="entry name" value="MOZART1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAG5092950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="78" mass="8790" checksum="6544701B0CE0FA76" modified="2022-05-25" version="1">MPGQVNHQVNISRKTFHTIYEISKLLNTNLDQTTLSICIRLCENGVNPQALAKVVKEIQKEVKALENNDIESTKALNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MMA5</accession>
    <name>A0A8J2MMA5_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS6729</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5093289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MMA5"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="24"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="43"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5093289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="78" mass="7650" checksum="97A9A0907DFA18D7" modified="2022-05-25" version="1">MSGTGSRGSGMSGTGSSGPGMSGTGMLSPGLLSGPETSRSGISRPGSLRSRMSLPRLSGPGMSLPGTWKSSKSTTTMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MN05</accession>
    <name>A0A8J2MN05_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS9240</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5099799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MN05"/>
    <dbReference type="OrthoDB" id="8062037at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40552">
        <property type="entry name" value="AT05186P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40552:SF6">
        <property type="entry name" value="FI09606P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="519"/>
            <end position="549"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5099799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="903" mass="104944" checksum="B9F227A855E572FB" modified="2022-05-25" version="1">MDVRRRASLENLFQLNPFNYIEKEKKLEHEDKLNRRKKADLPRQDLEPSQEMYPYECYPLNILNRRRAQLLDQIESSHFNPGDERKKIRIWRNMKADLQIDMSSFIKTESSPEVELETWTTGERCIPYRDQVLGLGAIDSNVGDVDVDDYATCRELGHARVPAVCLATKKTHQIVDRSTGERPGLVDGDYVTCEFESKGDYRLVYTQVCLRGTKGMHLIELARERTKTWKFCFYQALVALLAKTQLRYKFATSNNIDYIYDLAWMLFLHVGSLSINHKLRLDDVVVYNYNYCVEMELVQELKDVEKDSGVGFRFLEKGVKIRAMKRPELMKLTGELGQEKKKLFLDKPVHEGTKEIEHWFDKLPDNCRNCVFRTEKFALAFWKDGSFWYLYNPYRCDKFGFWDDNGKASVIKFCSRVALRRHLMILLVRAYAYGVNRGDLEQSEDNFEDLKSEKIGADTKGDGNVESEEVNFINDEQKLENVNDGEVQENYEVENVENKDENLASDEKNEENIKNTEEIRENDEKTLDNTNNLEIDKVNPENQEESTNNEENLYIKQRNQHHNSGNDKLTIQIFQLNYNCVKLHNLKLLCKNSSRPKTRPITKKVDEYDVSSNNLDSELVPSTEHIEKPSWLSENRITWSKVSSASPCRKARWHEYLVEEPRKLFSLWGEIHPTGRMFSPENRGKQIHACYLVCLGMSRIMAPEYWSSKTLDTVVMCGDRCYASSRLQSDAALGNSIDNNNQRNNADVDRARTSWESYLTRHFKIGDMLFEVKVLSAICGRLYSRNSLWKILQQMFLTHSYGVLTCESSCLAIFKFCGAYYVFDTNSFGPPIFDYGQGVAYLLRATSFQKLLKTLILIINSLESSRFSVNPVEILKIIDVESPCSKIKEKKLKKKLKRTKGCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MN13</accession>
    <name>A0A8J2MN13_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Mitochondrial (Danio rerio)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HICCMSTLAB_LOCUS9271</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5099861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MN13"/>
    <dbReference type="OrthoDB" id="9930022at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08248">
        <property type="entry name" value="RTN4I1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037397">
        <property type="entry name" value="RTN4IP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050700">
        <property type="entry name" value="YIM1/Zinc_Alcohol_DH_Fams"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11695">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11695:SF645">
        <property type="entry name" value="RETICULON-4-INTERACTING PROTEIN 1, MITOCHONDRIAL-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="6">
        <location>
            <begin position="143"/>
            <end position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAG5099861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="486" mass="54105" checksum="79EDCA8C3E79188B" modified="2022-05-25" version="1">MDEILFRLSSNLEALQIETSSIAQQAYQLVLSWLTECQRMLQNVCSDQYSQHIKDLGSFTASLYHRAYDNIHFGYYSARINFRDFYRQLGGFQSSDVSKRDVAFCTIGLAIGIFIGYNVGLNWKQKVKRIHYMKAIICHHYAGVEGVSLIDDAEVPSIQRSNELLIQVKAASVNVVDAKICSGYSKAYRRILNSGSIICIEQQKELPVVLGRDCAGIVVEIGPSVLGFDVGDEVFLAVPSWASGTMSEYLVVAENQVAKKPKLITFEASACMPYSGCIAWNALVNESIIEEGNAQNKRVLIYGGSTPVGCILIQLIKLWGGHVTVICKLESAKVIKALGADDIISSNDCDIYKELELHDKYHAIFYTEDHPIDYRALKRQLMPYGSFVSTVPEHLASDSFGFVSGSLFAGCVRIKLLVQYVFGRNINQWNEGSKIKPSYLETLRELVDADQLQSVVGAAFRPNHIEQALQHVLDPDAIGSTIIKFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MNK9</accession>
    <name>A0A8J2MNK9_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Polypeptide N-acetylgalactosaminyltransferase</fullName>
            <ecNumber evidence="16">2.4.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Protein-UDP acetylgalactosaminyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">HICCMSTLAB_LOCUS8547</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 16">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 16">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 16">Golgi apparatus membrane</location>
            <topology evidence="2 16">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 16">Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="16"/>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5097111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MNK9"/>
    <dbReference type="OrthoDB" id="330637at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004653">
        <property type="term" value="F:polypeptide N-acetylgalactosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006493">
        <property type="term" value="P:protein O-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02510">
        <property type="entry name" value="pp-GalNAc-T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000021">
        <property type="entry name" value="Polypeptide N-acetylgalactosaminyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045885">
        <property type="entry name" value="GalNAc-T"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000772">
        <property type="entry name" value="Ricin_B_lectin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11675">
        <property type="entry name" value="N-ACETYLGALACTOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11675:SF118">
        <property type="entry name" value="POLYPEPTIDE N-ACETYLGALACTOSAMINYLTRANSFERASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00652">
        <property type="entry name" value="Ricin_B_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00458">
        <property type="entry name" value="RICIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="Ricin B-like lectins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50231">
        <property type="entry name" value="RICIN_B_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14 16" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 16" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="12 16" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 16" id="KW-0430">Lectin</keyword>
    <keyword evidence="15 16" id="KW-0464">Manganese</keyword>
    <keyword evidence="13 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="6 16" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="domain" description="Ricin B lectin" evidence="17">
        <location>
            <begin position="469"/>
            <end position="601"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU361242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM00458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="CAG5097111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="606" mass="69888" checksum="604A32F5B8DA89F1" modified="2022-05-25" version="1">MWPIFRKICRTWPLVLSTILIILMVLVWSHKKLKSSEYADDYGSLRLTDDQRDYIDRKGIHVVVGHYIGDSVDPMKTPNVTKEIVNKNMFNPRAYDGKNGEPVLISSKDFPVMQQLFQINRFNLMASDRIPLNRTLPDVRKKKCIIRYANLTDLPETSVIIVFHNEAWSTLMRTVYSVINRSPRKLLKEIILVDDNSDREFLKESLDEYVKTLAVPTRVLRSGTRVGLINARLIGAKQAKGQVLTFLDAHCECTVGWLEPLLEAISKNRTRIVAPVIDIINDDTFAYTRSFELHWGAFNWDLHFRWLTLSGPLMKQRRENIVEPFKTPAMAGGLFSMDREYFFELGSYDDQMKIWGGENLELSFRVWQCGGSVEIAPCSHVGHLFRKSSPYTFPGGVGDILYANLARVALVWMDDWAEFYFKFNPEAARLRDKQQIRERLALRDRLKCRGFDWYLDNVWPDHFFPKDDRFFGKIVHRQTGNCLMKPLTKGMYAQPAGYAVTEPCVSPPDLIQMFVMTKDGIVMTDESVCLDAPERDTKHEKPKVKIMACNGLARQKWNYNHNTKALIHTGSEMCLAVNPNRDEGPVIAACNGNFEQQWELQSVPWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MP82</accession>
    <name>A0A8J2MP82_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Similar to FBXL14: F-box/LRR-repeat protein 14 (Homo sapiens)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HICCMSTLAB_LOCUS9258</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5099835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MP82"/>
    <dbReference type="OrthoDB" id="2585512at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22125">
        <property type="entry name" value="F-box_FBXL14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1280.50:FF:000059">
        <property type="entry name" value="Partner of Paired"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000546">
        <property type="entry name" value="Partner of Paired"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000569">
        <property type="entry name" value="Partner of Paired"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050648">
        <property type="entry name" value="F-box_LRR-repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047932">
        <property type="entry name" value="FBXL14_F-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057207">
        <property type="entry name" value="FBXL15_LRR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006553">
        <property type="entry name" value="Leu-rich_rpt_Cys-con_subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13382">
        <property type="entry name" value="MITOCHONDRIAL ATP SYNTHASE COUPLING FACTOR B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25372">
        <property type="entry name" value="DUF7885"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00367">
        <property type="entry name" value="LRR_CC"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="99"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="F-box/LRR-repeat protein 15-like leucin rich repeat" evidence="3">
        <location>
            <begin position="204"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="domain" description="F-box/LRR-repeat protein 15-like leucin rich repeat" evidence="3">
        <location>
            <begin position="372"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG5099835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="485" mass="53239" checksum="29E6EE5301DDA717" modified="2022-05-25" version="1">MEESQLLMTELPALTTGGTRGTLLHRSGQIYHLYQPHLTLTTPQHQSRQNSVSIHSYMNGGGATNLTKYKHGSVVRRKTLEERSEDAAPTSTHISCLYPEILALIFSYLNVRDKGRSAQVCVAWRDAAYHRSVWRGVEARLHLRKPSPVVFASLVRRGVKKVQILSLKRGLGDVIKCIPNLESLNLSGCYNVTDQGLNNAISDTVTSLTRLDLSLCKQVSDQALQKISQKIPNLECLELGGCCNITNHGLMLIAWGLKKLKYLDLRSCWHVSDQGLSYLAGFNSNEATLGSSLMLEYLGLQDCQRLSDEGLRHLSTGIVTLKSINLSFCVSITDSGLKHLAKMTSLRDLNLRSCDNISDIGMAYLAEGGSRISSLDVSFCDKIGDQALVYISQGLFNLKLLSMSACSVSDEGICKIAETLLELGTLNVGQCTRITDKGISAVSKNMKNLTCIDLYGCTGISTSGLQKIMKLPQITTINLGLWHVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MP99</accession>
    <name>A0A8J2MP99_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Similar to psuG: Pseudouridine-5'-phosphate glycosidase (Roseobacter denitrificans (Strain ATCC 33942 / OCh 114))</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HICCMSTLAB_LOCUS10525</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5101623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MP99"/>
    <dbReference type="OrthoDB" id="198885at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016798">
        <property type="term" value="F:hydrolase activity, acting on glycosyl bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004730">
        <property type="term" value="F:pseudouridylate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1790.10">
        <property type="entry name" value="Indigoidine synthase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022830">
        <property type="entry name" value="Indigdn_synthA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007342">
        <property type="entry name" value="PsuG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42909:SF1">
        <property type="entry name" value="CARBOHYDRATE KINASE PFKB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42909">
        <property type="entry name" value="ZGC:136858"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04227">
        <property type="entry name" value="Indigoidine_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110581">
        <property type="entry name" value="Indigoidine synthase A-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="Ribokinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0464">Manganese</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAG5101623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="441" mass="47293" checksum="B98B629CF45E4B92" modified="2022-05-25" version="1" fragment="single">MFWRNKFLLNNFGFCKPWRVIEKKFFHHERLVFGNENVTPATIGIIDGEIHVGMNEEQIHKLSNPDTKTFKCSAREICSIAAGGLNGGTTVGATVTIANLAGIAVMATGGIGGVHRNAENTFDISSDLIVMSHTPVSVETHGVPVISIGTKMFPAFYSRTTVDKIPAPMTVPGAREAARCINVQRMMKLSSGLIFAVPIPEAAALEPSEIEGLIQTALKEAESNKITGKEVTPYLLKRVKELTSGKSLSANKALIENNARVAGEIATELYNLSSQLNPAPGPKSALSTAINQKDQVVVIGGAVVDNILQVEEPIIKFDGRTNKGVSRKSFGGVARNIAASLLALGVGETKFITVVGDDQPGLEIFRSFGKNGRIKILSDINGECHFGFGEMDLLNSMEPNLVRDNRSGFEKAKLIVLDGNPSLETINEVIDIAVNCSVPGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MQ78</accession>
    <name>A0A8J2MQ78_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HICCMSTLAB_LOCUS5172</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5089272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MQ78"/>
    <dbReference type="OrthoDB" id="6581954at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005283">
        <property type="term" value="F:amino acid:sodium symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0089718">
        <property type="term" value="P:amino acid import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000175">
        <property type="entry name" value="Na/ntran_symport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037272">
        <property type="entry name" value="SNS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11616:SF303">
        <property type="entry name" value="SODIUM- AND CHLORIDE-DEPENDENT GABA TRANSPORTER INE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11616">
        <property type="entry name" value="SODIUM/CHLORIDE DEPENDENT TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00209">
        <property type="entry name" value="SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00176">
        <property type="entry name" value="NANEUSMPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161070">
        <property type="entry name" value="SNF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00610">
        <property type="entry name" value="NA_NEUROTRAN_SYMP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50267">
        <property type="entry name" value="NA_NEUROTRAN_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0915">Sodium</keyword>
    <keyword evidence="5 10" id="KW-0769">Symport</keyword>
    <keyword evidence="4 10 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="371"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="422"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="504"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="534"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="571"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="604"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="629"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="676"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="706"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="750"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="789"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="64"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="108"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="231"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="64"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="79"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="108"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="119"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="151"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="179"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="196"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="241"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="350"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="353"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="357"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="545"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="577"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="642"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="646"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="456"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR600175-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR600175-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAG5089272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="838" mass="93133" checksum="FE66B7AD39B444FF" modified="2022-05-25" version="1">MDLLTIEASKLALLKAQSMPHSNSRIGIITKPINIRKMSTMEEESSEDLDTSTHQIAVMNLGQQNNHSNNYTCNDDSDLSDHERERERGRLLSAGSRRIFIVPATAISGSNPSAQIGHTTTTTTSSTGSGNGNLISKKSSCSRNSSAESFQDSKSRRRDEELTMRISRDNSFHRESVNGHHHPNHNHHHHHHSHHRDQNGLHRENSAHGRFNRGVELYGGRHRYPSMRSLKSNATDEHHQQPTTSWASMSFSDATPSQSPARGAPFHESVSIRSLASIGLGSSDGRKLTIRRVPTSPSELLNMVQSPPLDDDMSTSDTDDYGTFDDLSDYHQPKRPHWANKIQFVLACVGYSVGLGNVWRFPYLCYSSGGGVFLIPYFIILIVCGVPLLYMELAVGQFTRRGPIGALGQICPLFKGAGLSSVVISFLMSTYHNVIIAYAIYYFFTAFKHEHPWANCNNSWNTPACWHPEAHGNRSKPNTSRTPSEEFFDKKVLQISAGIEEPGILRWEIVACLLTAWIIVYFSIWKSIKSSAQVWVNAAAQIFNSYGIAFGSMISFASYNKFHNNIFVDTLAVSLINGLSSLLVGIFAFAVIGNIAVEHNTTVNAVLTDGPGLVFVVYPQALAKMPASQLWAVLFFFMLVCLSLNSQFAVVEVVVTSIQDGFPNWVKKNLLCHEMLVLIICAVSFICGLPNVSQGGIYFFQLIDHYAASISIMFLAFFEVIAISWFYGVRRLCSNVSEMTGRVPSMYIQFCWLIAAPLLIMSVWVFSLIDYQSPTYGNGAYQYPWWAEAVGWGIASLSLICIPAFAVYVLIRAEGVTFTEVSLFSNTNVTCSTFTNFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MRC5</accession>
    <name>A0A8J2MRC5_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Similar to Cadm1: Cell adhesion molecule 1 (Rattus norvegicus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HICCMSTLAB_LOCUS12069</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5106044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MRC5"/>
    <dbReference type="OrthoDB" id="10055806at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013162">
        <property type="entry name" value="CD80_C2-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013106">
        <property type="entry name" value="Ig_V-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013151">
        <property type="entry name" value="Immunoglobulin_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23278:SF26">
        <property type="entry name" value="SIDESTEP III, ISOFORM O"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23278">
        <property type="entry name" value="SIDESTEP PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08205">
        <property type="entry name" value="C2-set_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00047">
        <property type="entry name" value="ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07686">
        <property type="entry name" value="V-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035263645" evidence="7">
        <location>
            <begin position="25"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="599"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="8">
        <location>
            <begin position="34"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="8">
        <location>
            <begin position="224"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="8">
        <location>
            <begin position="323"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAG5106044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="763" mass="85948" checksum="A9C0D234F6BEC166" modified="2022-05-25" version="1">MAFGERVILRGVYFFVVLFFCVNADENWDRDDDPISTSEVTAVLGKSASLPCDIEPSTRGDGVYMILWFRDNAVKPIYSIDARGRSFHRALNWSDEDVRPRANFVTISKPAALILDSIQLSDEGIYRCRVDFRKSPTRNFQVNLTVTYPPRELLMYDTSGRKIDTVVETDGHVDTNGQNVIFSTLIVPKLTREHLNTTYKCRATSTKLVPPLEKTVLLDVYLKPESVTIVSKPSQLVSGELYNLSCEVTGSHPRAKVHWLEGNEEFKSGSIIERSNSTVVYSTLEFYPTPEDHRKQLRCRGDNPALSNAFIEDSYHLNVVFPPKVQLEIGNTLNAQNIKEEDDVYFECKVRANPEHNRITWKHNGITLMQNPTAGIVMSSQNLVLQKIKRENGGNYTCLARASMDESVKIRCEVDADPNQVDFTWEFNNSGENFELAPAKFDGNNGTASEFLYTPMSERDYGALTCWGRNAIGKQKTPCVYQVIPAVKPSPVNNCTLKALLNQTLESLDVECAAGYDGGLRQDFRLEAYEAQTNLLRVNISSISPEAPVFRIPVADLLPANHFYLMVYAINAKGRSEVSLLEDIILRDSGKQTDTGVSFIPLLLLLIGCLMTLGITVLSVMLMFYRRRGTTSPVHVEPYMKQPIISPPDSRNNSMLDVTHGDHTYFVEYTLKQVGDYALNQPDIIQSPQDQEKVKREPQLFLPVRPDTLFAPYDIHKQGLQTNKCTLNPFSTKSWEPISFKADRNMMKEIIIANSIPGPESCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MSB0</accession>
    <name>A0A8J2MSB0_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Similar to Sos: Protein son of sevenless (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HICCMSTLAB_LOCUS11618</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5103655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MSB0"/>
    <dbReference type="OrthoDB" id="546434at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007265">
        <property type="term" value="P:Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22914">
        <property type="entry name" value="HFD_SOS1_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01261">
        <property type="entry name" value="PH_SOS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00155">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06224">
        <property type="entry name" value="REM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.3060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.840.10">
        <property type="entry name" value="Ras guanine-nucleotide exchange factors catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.870.10">
        <property type="entry name" value="Son of sevenless (SoS) protein Chain: S domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008937">
        <property type="entry name" value="Ras-like_GEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000651">
        <property type="entry name" value="Ras-like_Gua-exchang_fac_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019804">
        <property type="entry name" value="Ras_G-nucl-exch_fac_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023578">
        <property type="entry name" value="Ras_GEF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001895">
        <property type="entry name" value="RASGEF_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036964">
        <property type="entry name" value="RASGEF_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055251">
        <property type="entry name" value="SOS1_NGEF_PH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113">
        <property type="entry name" value="GUANINE NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113:SF363">
        <property type="entry name" value="PROTEIN SON OF SEVENLESS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00617">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00618">
        <property type="entry name" value="RasGEF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22697">
        <property type="entry name" value="SOS1_NGEF_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00147">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48366">
        <property type="entry name" value="Ras GEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00720">
        <property type="entry name" value="RASGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50009">
        <property type="entry name" value="RASGEF_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DH" evidence="6">
        <location>
            <begin position="160"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="4">
        <location>
            <begin position="394"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-GEF" evidence="5">
        <location>
            <begin position="695"/>
            <end position="934"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="935"/>
            <end position="962"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="978"/>
            <end position="1157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1179"/>
            <end position="1238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="983"/>
            <end position="993"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1025"/>
            <end position="1047"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1053"/>
            <end position="1069"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1071"/>
            <end position="1087"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="1088"/>
            <end position="1107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="1215"/>
            <end position="1225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1229"/>
            <end position="1238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAG5103655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="1238" mass="139836" checksum="14BFB0F32755897D" modified="2022-05-25" version="1">MFSTPASVASESSGYDFEKEENAAKWKGVFVNSLRKVLEQVHPSLEARQDALDYVESLILRMLGMLCGHPPPHTPQDIEERVRKTFPTPIDRWALRDARDALEKGKKKSPLVLPVDKIHQLLQKEVLQHKIDSQVLMDMFYQDDCTEGLQSSLGAVVSQTYEESVRDLIHDERHYLRDLHMIIKVFREEIAKLAPDKGELEKLFSNIMDIYEVTVTLLGSLEDIMEITEEKQTPTVGSCFEELAEAEEFDVYIKYAEAMNSPDSREVLTRLLSRPEANAALRAAGHGFKEAVKYYLPKLLMQPVWHCFLYFDYIKVLQKRTPSTEDSETLEQVQGLLRPLQMKLLQSVASLPKKDTGLRMQSRARRHAALEKTSELQKTVDGWDQRDIGQCCNEFIREDMLRKVASNGRRLTERRALLFDGLLVLCKPSGGKRVSVTVAAVGVGGGHPNHQGELRLKERFFIRKVDIIDREDTEEFKNAFEIAPRDHPNVILVAKSVEDKNSWMADLVMLNTKSMLERTLDSILLDEERKHPLRLPPPHLYIFAEQDCPENIVLEARENGGVPLIKDPSKVYGEEEKPSGCKATAREDWKRYRKEFCQPVQFRVLNVLRHWVDHHFYDFEHDKELLEKLQNFLEQVNGKSMKKWVDSVIKIVQRKCEPFEHRPITFSFEKSPPAIEWHLKVPEEEWEERGILTLHPIELARQLTLFEFELYRNVKPSEIVGSEWTKDNKEVTSPNLLKLMKHTTNFTRWLEKTILETENLEERVAVVSRVIEIMIVLQDLNNFNGVLAIVSAMASAALFRLHCTFQQVPARLLKALEEARDLGNDHFKKYQEKLRSINPPCVPFFGIYLTNIIHIKDGNPDYLPGNPKLINFSKRRKVAEITGEIQQYQNQPYCLSVEPRIRHFIENLSPFDADMPLADIDHYLYNKSVELEPRGTRQPLRAPRKWPDLNLKSPGIKARSMSGKLPAPLQAMASSVRLHDPTPEPAPELPETPPHNSQNMTHSSDHSVFAPILLGSTGPPPGSPGPLSMSGLSLGSPGNSPQLGSPGHLPSHHQPQTTHFGFNSGTINITGALAGLPSSSGSPGAVLPTPPSPSNMPLSQPPPPLPPRSHRRRESSISESPQQARQAPNAPILPPREGTSPPPPLPPRKDLLPATLPPRLPCTLNPCTSALLARRNSTLEGTSPNATHPRRYMSFNGPSPTTLPPTQPNGSVTPRLPPRPLPGRPPTMFNFNTPPGPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MSB1</accession>
    <name>A0A8J2MSB1_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS12477</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5106872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MSB1"/>
    <dbReference type="OrthoDB" id="7222477at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062129">
        <property type="term" value="C:chitin-based extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008010">
        <property type="term" value="F:structural constituent of chitin-based larval cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050468">
        <property type="entry name" value="Cuticle_Struct_Prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10380:SF2">
        <property type="entry name" value="AGAP003037-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10380">
        <property type="entry name" value="CUTICLE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="141"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="243"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="175"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="194"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="248"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="266"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5106872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="418" mass="48251" checksum="B547AB9B1A1AC112" modified="2022-05-25" version="1" fragment="single">LLICTVEIARAQFPDGDRGNAPTRRLPTMRTSVRFLPRQAARSSAVTPTIVPNPRLRRPIPLKSRPTSEANEIQQVTLPRAKPTFLPTLKSENLSTPPPQLLQQDQPIKPVSEEAREEEEDINQSFIKQLNSLHAFPQPTGSLFSSPLTPKPEPIFQYRPGFNSPVFIPRQIQYQQQQQQQQQQQQQHHQSSPTPTPTPSPTPTPSPVTQTTLAQHLHEEIIAPVQYRPPKPVKFRKPIDEEETRAPVKQHRKQQQHQHQHQQQQNSQSEVISEPQQYRPQADQWRQQPVNKQSSKKAQYREKKPVAQVVRRWREDNSDGSITWGYENDDGSYKEEVIGVDCITRGKYGYIDLDGIKREYTYVTGIKCDEQEHEELQDDLNGFVDYQENKLVFPNGKTIDLSSMGKKQSRRPQHVYRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MSN0</accession>
    <name>A0A8J2MSN0_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Similar to Adamts16: A disintegrin and metalloproteinase with thrombospondin motifs 16 (Mus musculus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HICCMSTLAB_LOCUS9208</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5099735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MSN0"/>
    <dbReference type="OrthoDB" id="7695528at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006509">
        <property type="term" value="P:membrane protein ectodomain proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1620.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006586">
        <property type="entry name" value="ADAM_Cys-rich"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041645">
        <property type="entry name" value="ADAMTS_CR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001590">
        <property type="entry name" value="Peptidase_M12B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11905">
        <property type="entry name" value="ADAM A DISINTEGRIN AND METALLOPROTEASE DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11905:SF249">
        <property type="entry name" value="SOL NARAE, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17771">
        <property type="entry name" value="ADAMTS_CR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13582">
        <property type="entry name" value="Reprolysin_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00608">
        <property type="entry name" value="ACR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50215">
        <property type="entry name" value="ADAM_MEPRO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M12B" evidence="9">
        <location>
            <begin position="151"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="313"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="312"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="316"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="322"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAG5099735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="485" mass="54681" checksum="652266BD57C93550" modified="2022-05-25" version="1">MCDDENFKIVTNHIHHEFTNEELRSVFQASRNAVPYYEVVPVAHNFHVRDFNEGPTVKINSFDQNLKMYLSPSDAFLVSENTPVWTAQPDKNSLNGVKYRKVKDPFNDVGQAYQDAQTNSAVVIYRSSRRIVERKRKSPLNRNKRSLPDVIYPQVLAILDSTLYQILNKDYKTAILYLLSFWNAVDLRYRTISNPKVRINVAGFIISVSEGGTPYLENNRRGDIELDADLALIDMSHYFYKETRFPFETYDMAVALTNYDICNVEYGYCDPSTLGYAFEMGACNRSSIDRNTEAVGIVEDNGGYGAILPAAHEVGHLAGVPHDGTEEASDCSGLDGYIMTPTVTFGHNSFHWSKCSKKLMDDFFAMSDASCLFDQPRRSKQIPLMLPGKIQTLDQQCQKVYGTKACFYDERVCTKLECQIPRGGGSCKSISSAAEGSKCGEGMFCIRGNCIAENSTTVPNWEKKKPEPNQFWDNFHPGPSTIKIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MT22</accession>
    <name>A0A8J2MT22_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS13114</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5108191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MT22"/>
    <dbReference type="OrthoDB" id="6021714at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5108191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="583" mass="65356" checksum="90C961260BF65B1E" modified="2022-05-25" version="1">MYFCFSGIEYGDEVYSICQLEARNSSNDLKKNKKVDEGKIDTKIIQNNIDLSKSIRKVTSSPICQIPKSNSSMPIKSPHRDIGASVITNKKEDSNTEFIFQNKPVIDYNSTRSYNDPSQSVTKKIFGDSSIGTTSDQDTLLSITNRSSPQTATASIFAPRTEDMNKGFLTFSDDQPGLTMLKDEPEDLTHLAPTPGDVCVPLEDTPFLSDMLDEFMLSNENYCTLLSPMIPTELPDSNSGLMEDTIQKNDNFGETLDSDPFFYTNPCSNLDSSQSTTNNLTNTPTKSPELFSIDLLHSSDTSNIATDSGISEDELLMLNIDEVIADDELALRAPYIPMSDQDEALQMLISDNMVMWGPTQPPDRSDWDSKRDSSDYYKESSLAKLLKNNKNSNKYDSISTVNLIKERDQTLEIGVNKRSNKRLHETSSLNTEEVNKRMKCQMMDKNTLIAAKKSSETDLFHTVKYTISVDGMNQKNIRINDNNLADTKANKMRLLQQLIEDRELSTTAESSNLNDAVNRTKHLDTINLMGDADGDDENLQDHQSNSVLMNLLISGCDKMYVDLPTLLEEKLRIPLSINVTEDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MTC5</accession>
    <name>A0A8J2MTC5_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Similar to PPP2R3B: Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta (Homo sapiens)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HICCMSTLAB_LOCUS12553</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="3">The B regulatory subunit might modulate substrate selectivity and catalytic activity, and might also direct the localization of the catalytic enzyme to a particular subcellular compartment.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5107035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MTC5"/>
    <dbReference type="OrthoDB" id="5586at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000159">
        <property type="term" value="C:protein phosphatase type 2A complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019888">
        <property type="term" value="F:protein phosphatase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.220:FF:000001">
        <property type="entry name" value="Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000628">
        <property type="entry name" value="Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.230:FF:000001">
        <property type="entry name" value="Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041534">
        <property type="entry name" value="EF-hand_13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048855">
        <property type="entry name" value="P2R3A_B_D_EF-hand"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14095:SF0">
        <property type="entry name" value="MIP22305P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14095">
        <property type="entry name" value="PHOSPHATASE 2A REGULATORY SUBUNIT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17958">
        <property type="entry name" value="EF-hand_13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21161">
        <property type="entry name" value="P2R3B_EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0106">Calcium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF-hand" evidence="5">
        <location>
            <begin position="803"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="147"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="373"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="478"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="932"/>
            <end position="1004"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="148"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="160"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="191"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="373"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="432"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="491"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="962"/>
            <end position="972"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="994"/>
            <end position="1004"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00093310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAG5107035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="1004" mass="113855" checksum="44AF29CE61FB9EDA" modified="2022-05-25" version="1">MAATAKHELRQKFPGESSGEEDIAAIAKQISDHAEAIYQSWKSRGLAPAEIFNCHNSATAADEFDSALTPTLSPTSRGLQLENILKVGAAGQSYSPPPPRLDNNNTLEKLVNNFVVEDKARQQRTSSYISKNLPSSIQSALERFERNSPGNVTNNIRHTQQQQQQHQQQQKQQQQQQQQQQQTRPKIATKSSLSSPLASPSSLGETIETILPADLPGNGTTNQPKRPLSVLLNTTTPTNTAAGELSRPNQSSGLTTWPLKNKLFTDSSVVARVNASKATVASSYLDEVAREEERLINALKTGVVIDEDGSSPVPVRQKPAIKKEKPKLMTNGVVLERTSQFIQQIQQAKKIDERKATTNTVVEKIEKNSIQQQQQQQQQQQQQRQSQQDVKEDREVQIVASKWGPRITSPRPRIDQVPHPELTNQQKQHIRAAAAAAAATDSSSSAGNNANPVRPFLTRGSVAERVLIFEKCPSELLLDKRGPRQPGGPSSRFNSNDGKPQSSYVRERIQQQQSRALPPHTTLQRHVKANKNVRIPRFYFPGGKPTPPTQLEATIAKISKAFENLPGHRASRSQFNIITKACELPLYLKVPLFLAAGGDATTSVEMNNFIEFWKEINKSYHDPASKFIRITTRGLRNYILPEDLVAMVQDVVDTHPGLTFLKEATEFHSRYVHTVIARIFYCVNRSWSGKISVTELRRSNLLAVIGILEHEEDINQVTSYFSYEHFYVIYCKFWELDRDHDLFINKMDLTRHNDHALSTRLIERIFSGAVTRGRGKNGEVRLQEEKMSYTEFVWFLLSEEDKNYPTAIEYWFRCMDLDGDGYLSMYELEYFYEEQLLRMEAIGLETLPFEDCLCQMLDMIKPKIPGKISLSDLKNCKMTSIFFDTFFNLEKYLDHEQRDPFASTRDHDAEGHELSDWDRFAADEYELLVAEESGNEQNDQMMYDNGIDEDGFTTINTLPEESNDRNKKRDGYTKNYQDTGESRRDSKNQNYDSGDSDDYAESDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MU50</accession>
    <name>A0A8J2MU50_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Mitochondrial pyruvate carrier</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HICCMSTLAB_LOCUS13176</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Mediates the uptake of pyruvate into mitochondria.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Mitochondrion inner membrane</location>
            <topology evidence="1 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the mitochondrial pyruvate carrier (MPC) (TC 2.A.105) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5108316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MU50"/>
    <dbReference type="OrthoDB" id="1697690at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006850">
        <property type="term" value="P:pyruvate import into mitochondria"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005336">
        <property type="entry name" value="MPC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14154">
        <property type="entry name" value="UPF0041 BRAIN PROTEIN 44-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03650">
        <property type="entry name" value="MPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="10" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="45"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAG5108316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="102" mass="11842" checksum="47962F2E6F396BF8" modified="2022-05-25" version="1">MSVVKKILNQKETREWLMSTHFWGPVLNWGIPIAAISDFKKSPEIISGNMTLALIVYSMAFLRFAVKVQPRNMLLFGCHTVNLTAQIIQETRFINYHYIQNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MV36</accession>
    <name>A0A8J2MV36_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Similar to L3MBTL3: Lethal(3)malignant brain tumor-like protein 3 (Homo sapiens)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HICCMSTLAB_LOCUS13843</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5109207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="8188861at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20101">
        <property type="entry name" value="MBT_L3MBTL1-like_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20102">
        <property type="entry name" value="MBT_L3MBTL1-like_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20103">
        <property type="entry name" value="MBT_L3MBTL1-like_rpt3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09582">
        <property type="entry name" value="SAM_Scm-like-3MBT3_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.140:FF:000007">
        <property type="entry name" value="Lethal(3)malignant brain tumor-like protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.320.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004092">
        <property type="entry name" value="Mbt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050548">
        <property type="entry name" value="PcG_chromatin_remod_factors"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002515">
        <property type="entry name" value="Znf_C2H2C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12247:SF131">
        <property type="entry name" value="LD05287P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12247">
        <property type="entry name" value="POLYCOMB GROUP PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02820">
        <property type="entry name" value="MBT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00536">
        <property type="entry name" value="SAM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01530">
        <property type="entry name" value="zf-C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00561">
        <property type="entry name" value="MBT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00454">
        <property type="entry name" value="SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63748">
        <property type="entry name" value="Tudor/PWWP/MBT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51079">
        <property type="entry name" value="MBT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50105">
        <property type="entry name" value="SAM_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51802">
        <property type="entry name" value="ZF_CCHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="repeat" description="MBT" evidence="10">
        <location>
            <begin position="764"/>
            <end position="862"/>
        </location>
    </feature>
    <feature type="repeat" description="MBT" evidence="10">
        <location>
            <begin position="870"/>
            <end position="970"/>
        </location>
    </feature>
    <feature type="repeat" description="MBT" evidence="10">
        <location>
            <begin position="979"/>
            <end position="1074"/>
        </location>
    </feature>
    <feature type="domain" description="SAM" evidence="12">
        <location>
            <begin position="1308"/>
            <end position="1372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="297"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="507"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="665"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1137"/>
            <end position="1249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="320"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="445"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="513"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="665"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="706"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="733"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1151"/>
            <end position="1167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1178"/>
            <end position="1202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1238"/>
            <end position="1249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAG5109207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="1374" mass="153184" checksum="9B07498436E52416" modified="2022-05-25" version="1">MEETIHVEGISNLEIVQQRVSAANENDSTTAATHIVPLVYIQPNKVQHTSPLNQQISTSALQIVNSSTSTAAIINPINAPITAQNKVFIQGPHTISLSSKQHYVIRQPITASVVTTAPTSTQVQKHILVRKPAHILPLNKTPSPPPQQSSLPPVSPTNQINNLQSGKHNNLTFINTYEKPIKPRMDFSMPIPTVAATTAVTGTLSTNQAVVPKSKVVISPVQTAGQTSTTVSGSPAKNISNFLLPVNISPPGLTESSKQNVFNLKVTNGKLNNSVEITTTSNSNCNSNTSKGAITVLRESSKSSSSSNNPPPLHPITKINLLNKNAGINLNSSAPPSPSTDGIKITENPDSAVITPIPNNNDNSGNKNDEYSEKRKKTVSNILSRGPVAVTEKRPKKQNLSKTRECPEDNELYDQLDIPQLLGKNSRDKKSNQNDDEITLIKVIPSQTGKSNKNINNKSDRSSTEINSVDDDIKIEMIKSSSNVNSSLMNGDKQNIKSNNHAEEVNGNTAQYHNNNNNNNNNTNNHNNNHRHPHNDSNFDVTKALEWKDGVGSLPGSTLKFCINEFGLMEVVDDDNSKQDKHNNIGDKENVCLSPRNSFKPTSAITITSTTTEKKNEEKKNRNAVSSDTLYCCENCGCYGLAAEFDSPISCSPACSTAIEDKKQLQLRREKDARESKIKRKKKKLLQEKLTKTQQSEQEHEESEQKDDKKEQIEIKSDPSRLTPKVESDDDTSINNLDETSRQSGGNEAATEPKYPWQTGKLGFSWAKYLEYTKAKPAPLKLFKDPFPYGKNLFKVGMKLEGIDPEHPSRYCVLTVFEVVGYRIRLHFDGYPENFDFWVNSDSIDIFPVGWSEKHGHRLNPPKGYVPSNFNWNAYLKTCKATPAPKVAFSNHKSTTFAPVGFRVGMKLEAVDRKHSPSVCVASIAGVMDSRILVHFDSWDEVYDYWAYPNSPYIHPVGWCHHNGHSLTPPNNYKDSKSFTWDAYLRETRSVAAPSRAFKQRAPLGFKRGMKLEAVDRRVPQLIRVATIEDVKDHMIKIRFDGWSEVYSYWIDDDSPDIHPMTWCSKTGHPLEAPLTPELLNERTECGTPGCRGVGHVKGPKFATHNSASGCPYSPQNLHKIRMVSDRLNVKHEICDYDEDSSSPTSYDFIPKTEKSEKVRTSADRSGKHSPINNYKSLKLEKDIKPEDYESDHRQETSERSKKFSKHNYNNSDAGQSEDDDVAPPPLKKRRKKRQVSEESNFSLPVTDTTGNLCGTNNIPDKQLRTEIHQSVFNPGYNPLPDAPHMWAKHSNALNRVVAKQNTNPRRWSNEEVIKFISNVPNCKEVGSIFRKHSIDGEAFLMLTQEDLVSLLGLRLGPAIKLYNSIVLLRRKAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MXH9</accession>
    <name>A0A8J2MXH9_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peroxin-19</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HICCMSTLAB_LOCUS11540</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peroxin-19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5103499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MXH9"/>
    <dbReference type="OrthoDB" id="21292at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033328">
        <property type="term" value="F:peroxisome membrane targeting sequence binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045046">
        <property type="term" value="P:protein import into peroxisome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.900">
        <property type="entry name" value="Pex19, mPTS binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006708">
        <property type="entry name" value="Pex19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038322">
        <property type="entry name" value="Pex19_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12774">
        <property type="entry name" value="PEROXISOMAL BIOGENESIS FACTOR 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12774:SF2">
        <property type="entry name" value="PEROXISOMAL BIOGENESIS FACTOR 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04614">
        <property type="entry name" value="Pex19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="31"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00029688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG5103499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="300" mass="33167" checksum="AF09FC0480438B68" modified="2022-05-25" version="1">MSDKNKSNKQSADPELDDLLSNALGDFDRLSVTNEQKQDQTASSTSKEVTKDLEKSPEPLIDEMWSQEFINQTASQFQKNLQKIIQNGSDGDFNASLAKMAQTVAESMASTSGADGESAADIGDNLDFQAAIAQAFKDIPHPTEEMKASGSGFNETELLSMFGQPSDESGGDIFPFMQGMMQSLLSKEVLYPPLKDLVDKYPDWLDEKKSNLAAADFERYTRQFLLMQKVCKELETEKSDDADEVKKSRFDKVLDLMHEMQTCGQPPDDLIGEQTGLFQLDDMGNPVLPPGVDPSNCCIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2E6B9</accession>
    <name>A0A8J2E6B9_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Phosphodiesterase</fullName>
            <ecNumber evidence="9">3.1.4.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HICCMSTLAB_LOCUS1258</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="9">Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the cyclic nucleotide phosphodiesterase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.-" evidence="9"/>
    <dbReference type="EMBL" id="CAJNRD030001116">
        <property type="protein sequence ID" value="CAG5075090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2E6B9"/>
    <dbReference type="OrthoDB" id="74705at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047555">
        <property type="term" value="F:3',5'-cyclic-GMP phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046068">
        <property type="term" value="P:cGMP metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1300.10:FF:000003">
        <property type="entry name" value="Phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.40:FF:000031">
        <property type="entry name" value="Phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1300.10">
        <property type="entry name" value="3'5'-cyclic nucleotide phosphodiesterase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023088">
        <property type="entry name" value="PDEase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002073">
        <property type="entry name" value="PDEase_catalytic_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036971">
        <property type="entry name" value="PDEase_catalytic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023174">
        <property type="entry name" value="PDEase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11347">
        <property type="entry name" value="CYCLIC NUCLEOTIDE PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01590">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00233">
        <property type="entry name" value="PDEase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00387">
        <property type="entry name" value="PDIESTERASE1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55781">
        <property type="entry name" value="GAF domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109604">
        <property type="entry name" value="HD-domain/PDEase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00126">
        <property type="entry name" value="PDEASE_I_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51845">
        <property type="entry name" value="PDEASE_I_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0140">cGMP</keyword>
    <keyword evidence="5 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="PDEase" evidence="11">
        <location>
            <begin position="514"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="20"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="6">
        <location>
            <position position="593"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="593"/>
            <end position="597"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="597"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="633"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="634"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="634"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="634"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="744"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="744"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="797"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR623088-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR623088-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR623088-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAG5075090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="947" mass="107105" checksum="5DC4E028AE3254F5" modified="2022-05-25" version="1">MKISMIPRSPETPDKRECTLVSSSDSKGPLSETNTTAGNNNLYNTSDDKDAKEKAKKKTLCEETVYEFEEDGLTMERVGKYLESNPLVVEAWLRDKASNELKVKLLNTSLLKQQSSLIVRGQKSQESQPRKRNSVTTDLFQSWLASNSPIKRSKSPNRLSTSMSGRRAELTQLDEGELFMELIRDVANELDINVLCHKILVNVGLLTHADRGSLFLAKGPQDERYLVAKLFDVTQDTELEDAIQKANSEEIRIPFGVGIAGYVAQTKEIINIKDAYSDPRFNSKIDLRTGYKTTLILSMPICNYEGDVIGVAQIINKTNGSNEFTNRDIEVFKRYLTFCGIGIQNAQLFELSVLEYRRNQILLNLARSIFEEQNNLECLVTKIMTEAKELLKCERCLVYLLDLDCGEAGHLEKIVERPGKSVQEDRKPLSRRESNNIDMEDILSRQALASDGSSKFTMVFEMENGVQEARVSRPSVSELASPLGRIARYVASTGQILNIGDAAIWLRKGVIDQSKEPIKSILCMPIVNGQRSVIGVAQLINKDNGSSFTDSDVSIFEAFAIFCGLGIHNTQMYESACKLMAKQKVALEPVKYHNWRHALNVAQTMFAMLKTGKMEQFMTDLEILGLLVACLCHDLDHRGTNNAFQTKTESPLAILYSTSTMEHHHFDQCVMILNSDSNNIFQTLSMEDYRRVMKVVESAILSTDLAVYFKKKNKFMELIDDGEFDWQSEEKKELLCGMMMTACDVSAIAKPWDVQHRVAKLVADEFFDQGDLEKLQLNQQPVAMMDRERRDELPQMQVGFIDVICLPLYKVLSETFPWIMPLYEGTTENRRNWQDLAEKVEMGLTWIDRDTIEEPVEEFVSQEPKDIEFTVTTLNCTTATPGTAKEFPKTALGRFASLRKGGRSLGKGVRHRLSKSLYTRNNSEDTGKVKVMLPDRKSNKNKLCLLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2E6T4</accession>
    <name>A0A8J2E6T4_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Similar to Retrovirus-related Pol polyprotein from transposon TNT 1-94 (Nicotiana tabacum)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HICCMSTLAB_LOCUS1529</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001116">
        <property type="protein sequence ID" value="CAG5075375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2E6T4"/>
    <dbReference type="OrthoDB" id="8063677at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054722">
        <property type="entry name" value="PolX-like_BBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47592:SF27">
        <property type="entry name" value="OS08G0421700 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47592">
        <property type="entry name" value="PBF68 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22936">
        <property type="entry name" value="Pol_BBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14223">
        <property type="entry name" value="Retrotran_gag_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="240"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="428"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="436"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG5075375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="574" mass="66492" checksum="0B0DFFBC802C3ED2" modified="2022-05-25" version="1">MAEKETANLTKLDGKNYQMWKFGISYLLDSKELSDYIDGTDVEPDKVTKLVDWKIWKKSRAQAMVLLLSSVDHVLHPNLINCESPKAVWDKLKALYGETNEDEITSAWQRYYAYNIVDSEPINTQIEKFESLHKTLTDSGEKLSEKSIISKLLSSLTPRFSAFRMAWECTAKDEQRLTNLTARLIREDKRLKDSEESEMMSALQVNVMKKQFQQMKMRQETHQERQERLNKVRELKKRTRCHKCGKIGHWKRECTEQAENDEHQEVIGRESQTYICEVSALNTEDYIQEKDIWIADSGASMHMTWRREIFQNFNPSETIKHVKIADDKLLPISGTGVVNILVDLNRKVYDRTLLNVLLVPGLRRNLFSVGAVNKKKFSFHAYEQHCEVRDQDGELSSVGVSFGDLGEGHYDVGGDGEPAVIEQVEERRGLGPQHELDEENQPGEIEEEDGRQIPQHEIEEENREQPNQETMDFEAINKVNHLEDFSPTKKLTDLTINNEYRISELKIVNTKFGPRIIATIDDLYVVFLPARTAKLLKDPEDIKKFNVAALKKELFLLYLGGQFNNFEFLRKNLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2E941</accession>
    <name>A0A8J2E941_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Similar to Sec6: Exocyst complex component 3 (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HICCMSTLAB_LOCUS625</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SEC6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001114">
        <property type="protein sequence ID" value="CAG5073829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2E941"/>
    <dbReference type="OrthoDB" id="10047020at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000145">
        <property type="term" value="C:exocyst"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051601">
        <property type="term" value="P:exocyst localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.357.50:FF:000010">
        <property type="entry name" value="exocyst complex component 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.357.70:FF:000001">
        <property type="entry name" value="Exocyst complex component 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.70">
        <property type="entry name" value="Exocyst complex component Sec6, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010326">
        <property type="entry name" value="EXOC3/Sec6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042532">
        <property type="entry name" value="EXOC3/Sec6_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21292:SF1">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21292">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT SEC6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06046">
        <property type="entry name" value="Sec6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG5073829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="755" mass="87341" checksum="37690D39C1308064" modified="2022-05-25" version="1">MIGTTNLTDLQKLEEEAKATATKHVMNMLQRPGQLEKVEQYKRRITRKKASVETMLKTAMQSQLDGVRVGFDQLQTSLSTIASIKDEVDLIGQSFGSALELNTKLQPVQEENMRHSQYVTAKENLKHIFTVPESVEKTKTWINEGKLLHAHQSLMDLENSRDDLLYELHKLPNQSLPDKVMLKAYFEDVETLSQLMEKQIKLVLSRTLNTVRKEPTVIVTALRIIEREEKADQFAVQRFRQSGFMPPGRPKKWKDMAMQTLEKSVANRIEGTQVDERADNKMWLVRYLELTRQLIQEDLRVVKTLCGPCFPPYYDIVNKFVRMYHGCLSQHLKDIIANGLEGNEYVSLLGWIMNTYPGADLMLHPELNINISEIGDLLSKEILDELQEKYLRNMCQNYEEWMKKTLETEKADWWSGKAPESSSQDTYYHTAAPVIIFQMIDQNLQVTKTISNELTAKALVVCIEQVNKYGLMYRQAIMEFKAKHFDDRSQVPYFTHHMITVVNNCLQYVELAQQMKQLYWVTNATSDAAVKFENLLANYQQLRNEAVAILLEESLLDLETKFQDLLTPKWLNTSIAVETICVTLEDYFQDYGHLRVKNFEYVINEAQNLIAKRYIAAMLSRKISLKNYDECLTCTSKIMSEADKLKNFFVRIAPKVGNFDSPFEIIKRLAEVLRCEDAEILTLDLHSLVEKYPDMTDDHLVRLLSLRGDIPRSEAKEKVAYILEAQKNRTSSSQSISNSIFKQIVLQDSFLSWKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2EAC0</accession>
    <name>A0A8J2EAC0_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Similar to arl6: ADP-ribosylation factor-like protein 6 (Danio rerio)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HICCMSTLAB_LOCUS455</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001114">
        <property type="protein sequence ID" value="CAG5073512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2EAC0"/>
    <dbReference type="OrthoDB" id="442317at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="24"/>
            <end position="31"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="31"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAG5073512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="77" mass="8849" checksum="1A271117C36ED70C" modified="2022-05-25" version="1">MKLFDRLVHALGLKKKEVNVLVVGLNNSGKSTVINHFKREDERCIDIVPTVGFNVEKFACKFCVIVLSELFHRFPNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2EAE3</accession>
    <name>A0A8J2EAE3_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">pyrroline-5-carboxylate reductase</fullName>
            <ecNumber evidence="3">1.5.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HICCMSTLAB_LOCUS401</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-proline biosynthesis; L-proline from L-glutamate 5-semialdehyde: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the pyrroline-5-carboxylate reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.2" evidence="3"/>
    <dbReference type="EMBL" id="CAJNRD030001114">
        <property type="protein sequence ID" value="CAG5073458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2EAE3"/>
    <dbReference type="OrthoDB" id="10263291at2759"/>
    <dbReference type="UniPathway" id="UPA00098">
        <property type="reaction ID" value="UER00361"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004735">
        <property type="term" value="F:pyrroline-5-carboxylate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055129">
        <property type="term" value="P:L-proline biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3730.10:FF:000001">
        <property type="entry name" value="Pyrroline-5-carboxylate reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3730.10">
        <property type="entry name" value="ProC C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01925">
        <property type="entry name" value="P5C_reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028939">
        <property type="entry name" value="P5C_Rdtase_cat_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029036">
        <property type="entry name" value="P5CR_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000304">
        <property type="entry name" value="Pyrroline-COOH_reductase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00112">
        <property type="entry name" value="proC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11645">
        <property type="entry name" value="PYRROLINE-5-CARBOXYLATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11645:SF69">
        <property type="entry name" value="PYRROLINE-5-CARBOXYLATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03807">
        <property type="entry name" value="F420_oxidored"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14748">
        <property type="entry name" value="P5CR_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000193">
        <property type="entry name" value="Pyrrol-5-carb_rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5 7" id="KW-0521">NADP</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-0641">Proline biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyrroline-5-carboxylate reductase catalytic N-terminal" evidence="8">
        <location>
            <begin position="11"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="Pyrroline-5-carboxylate reductase dimerisation" evidence="9">
        <location>
            <begin position="184"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="15"/>
            <end position="20"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="67"/>
        </location>
        <ligand>
            <name>NADPH</name>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="80"/>
            <end position="83"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000193-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF14748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAG5073458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="290" mass="30866" checksum="89BEFA4D51E9D581" modified="2022-05-25" version="1">MTQTINLQSLKVGFIGGGNMARAIGLALIKRNILNPKNVWISARTRETLQNWNQLTSENPVNTTLNNADIIINSDIIFLAIKPQSLVLAIEDAKKTSEGRNLMLNNKLFVSVLAGVTLDTLEKEIQLHLGQQLPLKIIRTMPNTPLSIGEGITVYSRNAQVSESDALPLVKMLSQIGIIEEIPENLINSAGGLAGSGPAYAYLMVEGLADGAVKTGLPRALATKFAAQVLVGAGKMVLQTEKHPGQLKDEVCSPGGTTITGMHALETGAVRASLMNAVDAAVRRSKELGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2EBE2</accession>
    <name>A0A8J2EBE2_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS1015</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001114">
        <property type="protein sequence ID" value="CAG5074314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2EBE2"/>
    <dbReference type="OrthoDB" id="8049018at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579">
        <property type="entry name" value="F5/8 TYPE C DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579:SF1">
        <property type="entry name" value="F5_8 TYPE C DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="398"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5074314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="423" mass="48224" checksum="1B19DAB67F248257" modified="2022-05-25" version="1">MNLYNQVLCDQIVDLMNNGVNIFNHATKQNCNLKFTLLCCCVDTPARATCQNRVKFSGYYGCSWCYEPGLYVGHAVHYPLSEIEPNLQTHKDHISNVNELEKIKKTSDSKSKVPTVMGVKGSMIFIEKLPLFNSIWGFPIDYMHGCLLGVTRQVLQLLKTPGVKFQLTKKQREAIDKRLISIKPPHEIYRLPPDQLVICVSGRHQNSSLGCFIGVFYAWMKITDEEITRTQYDLAKFFGLFQIEFSKSAMTFNLHSLWHLCESVLQTGPLTGTSTFASENDELVLAGKTRIHERIENKIKSLINDNTVVIHDAYKKCIYKKTVIHSASYIYGCPLNISPYSIGNVEIDHIHRITNSCENDFIIICISNFKEKKKTIITRKSEKLPKPITMIVPQSHKLEGNRGNLNETQTQRDDIEISPLPFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2EC65</accession>
    <name>A0A8J2EC65_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Similar to ubxn1-a: UBX domain-containing protein 1-A (Xenopus laevis)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HICCMSTLAB_LOCUS883</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001114">
        <property type="protein sequence ID" value="CAG5074111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2EC65"/>
    <dbReference type="OrthoDB" id="10254930at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036435">
        <property type="term" value="F:K48-linked polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032435">
        <property type="term" value="P:negative regulation of proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903094">
        <property type="term" value="P:negative regulation of protein K48-linked deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031397">
        <property type="term" value="P:negative regulation of protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14302">
        <property type="entry name" value="UBA_UBXN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01772">
        <property type="entry name" value="UBX_UBXN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041923">
        <property type="entry name" value="UBA_UBXN1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001012">
        <property type="entry name" value="UBX_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46340">
        <property type="entry name" value="UBX DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46340:SF1">
        <property type="entry name" value="UBX DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22562">
        <property type="entry name" value="UBA_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00789">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00165">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00166">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50030">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50033">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UBA" evidence="5">
        <location>
            <begin position="2"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="domain" description="UBX" evidence="6">
        <location>
            <begin position="228"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="27"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="205"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="51"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="65"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="80"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="208"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAG5074111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="311" mass="34782" checksum="93C4D67B66E602B3" modified="2022-05-25" version="1">MAEDSPFVAMLVDMGFSKERSEKALKATGNVGVQPAMDWLFSNTEDEVPQTGASSAETQVSPQESSSAQSSASTATASTEKVEYHATKSGHDSFSESLEEKKPLTEDEKKEKLKQLEEKMRQKRKEREELEKQESLEKEKIRIKSGKEMAEAKKKMEELEMKKLLEQRKREKEEDRIARQAIREKIEADKAARRAKAAAEYGNLVPSVPVPTPAPAPAPAPTPAAPKRDYTETRLQIRLTNGDTLTQTFGAKEQLSAVRLYIEMNRTDPPGPFNLLTNFPRKVFSFEDYDAPLDVLGLVPSAVVIVQKKVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2EIX6</accession>
    <name>A0A8J2EIX6_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS794</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001114">
        <property type="protein sequence ID" value="CAG5074022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2EIX6"/>
    <dbReference type="OrthoDB" id="10382847at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="16"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5074022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="581" mass="66255" checksum="1BECD9C56FFDD41D" modified="2022-05-25" version="1" fragment="single">ELNNPPAVPLRRKKTSSNNKLLKSNLSPKQPIKNIIISSGASSSNKLIKEDNDKNLIKYSSNLNKKKLNIPVIKEPKIQEDKKLKIKNNPTLLFTTRDFESVMEHSDMNRVSHQLNSQKFQTKINNDGISEETTCFTITASNLPFATFKRELTNENFTLNKNKNQNGSFDFDCEKNNKFFHDLKIQNLENESKEFNYENKSVKNANKIDKKNHSKTPNQMKNDLLNELVTNFNELKLKKISIPSQVTDKNDSDKKVMVGKINNVNSNSNKNNNGINCVISMNNSACNIGKKTDDKDLEIDNYNNDTTSLKRMKKNNNPPILPAKIISNFTDDKISRLCINNNNNNNNYNNGIDNNIIEKTYTLRRKKSGRVSHNYGKNDQINNSKKNIIINNNNYRNENSDIASDSCVEKDIKINMNDKKIVVEIEHTLVKKRGGVIDYKVNGGKNLSSDEFNLKPTGSCLRNSSSISQICHKKVMFNGNKTTGANKFKKVKRRAPPRPFSKSKGAIECTVCDNHEEKQDLGKFNDTNFGKIRRLTSEAYSQPTNEENSPRHNVKSGKNRIVLFQSLFNNRVCKYCVKVNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2EJW6</accession>
    <name>A0A8J2EJW6_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Similar to Ankle2: Ankyrin repeat and LEM domain-containing protein 2 (Mus musculus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HICCMSTLAB_LOCUS1411</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ANKLE2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001116">
        <property type="protein sequence ID" value="CAG5075257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2EJW6"/>
    <dbReference type="OrthoDB" id="7446186at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051721">
        <property type="term" value="F:protein phosphatase 2A binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056237">
        <property type="entry name" value="ANKLE2_3rd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12349">
        <property type="entry name" value="ANKYRIN REPEAT AND LEM DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12349:SF4">
        <property type="entry name" value="ANKYRIN REPEAT AND LEM DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24567">
        <property type="entry name" value="ANKLE2_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="614"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="domain" description="ANKLE2 third alpha/beta" evidence="6">
        <location>
            <begin position="294"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="690"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF24567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAG5075257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="690" mass="78029" checksum="2539E14CCC360E2C" modified="2022-05-25" version="1" fragment="single">MSVNGLINTKSDHLNMLDSLKTNKNVYHAVFVNEKPTTPETEELDNELHVYQDKLDALKVIKKYKTGRLKTFSSWEEAEKYARYGDSLNYSVNGSNVDGKVVAENSCKPVDEKGPNFKSLKPQELVVFRKLIETGDLEGVKNCIWENPRYLVGVSGNPTILQEGPRYNALHVATSKSSDAFNMCKLVLDVISDPNFIELIDGIEETASYVNKSQVFIEAFLNTPNKGLNETPLHFAVKYGLKDVVALLVSYPQCSRTAKNKHGQTPMEIICDRKPLEDDGKLIREIRALLEDQYYVPVIRSEDNSLAPAIGEPFSPASPPRLVIDPISPRLEVKAFAGPMTKPQALEFRKKWKTPPRMLFGTPKRDTSINDPLHLEKLDCRLIDLEKGLERVGRDLAEEYHVSWKEFWPFLNEFADLKSTSGLDKLEKYLSKLQRFKTINSVKQGKSYPKFKSIKNLSKDFKTANCIQSDNKDDIDDIKPIDFYSKQEDEKNLLNKFENNFIDKKDNDMDALIKNMELLILNSPKNVVAEEKFYTPPSSPLPFDDYSDFSEDSSSEDEMFMPSEGHPVFIQGSVPSKIDIAVLNALPETIDPEVYPLIYQWKHDLQLAVRKNDISVNLIIVIVFVMAGGVCLSCKIIDRIRDTSLDIREDFGLKSHSFAIRSHSVPGSTSPASATNCFSAFLLKKISTLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2EKJ0</accession>
    <name>A0A8J2EKJ0_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Similar to Pitx3: Pituitary homeobox 3 (Rattus norvegicus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HICCMSTLAB_LOCUS1999</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001116">
        <property type="protein sequence ID" value="CAG5076018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2EKJ0"/>
    <dbReference type="OrthoDB" id="6159439at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051000">
        <property type="entry name" value="Homeobox_DNA-bind_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000047">
        <property type="entry name" value="HTH_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24324:SF5">
        <property type="entry name" value="HEMATOPOIETICALLY-EXPRESSED HOMEOBOX PROTEIN HHEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24324">
        <property type="entry name" value="HOMEOBOX PROTEIN HHEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00031">
        <property type="entry name" value="HTHREPRESSR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 5 6" id="KW-0371">Homeobox</keyword>
    <keyword evidence="4 5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="7">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="5">
        <location>
            <begin position="3"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG5076018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="95" mass="11750" checksum="88F4B8B150BE0BA4" modified="2022-05-25" version="1">MEKKQQKITFTKDQCLFLEETFRKNRYPRTSIREQIAESLGLTERQVNNWFGNRRRKERDNFYQNVNQDQTCQVDEQKENWYQNVNQGQNRQVEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2ELP1</accession>
    <name>A0A8J2ELP1_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS46</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030000366">
        <property type="protein sequence ID" value="CAG5071444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2ELP1"/>
    <dbReference type="OrthoDB" id="7555293at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5071444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="117" mass="13398" checksum="A28CA8C23A60D601" modified="2022-05-25" version="1">MANSPLPSLTLDLQKKLTEDGVLKAQKYFIKFWASYLWEVTNTKPTKFDYHNLATSIVQAYSELKGGSNECEIVRSQLSIWIRNHRYGLKKTGSIKRDHDGNNKPPTAQTVFVENHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2EP28</accession>
    <name>A0A8J2EP28_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS2164</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001117">
        <property type="protein sequence ID" value="CAG5076364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2EP28"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035181193" evidence="1">
        <location>
            <begin position="21"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5076364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="227" mass="25964" checksum="2A7C2DF8ADA23AA5" modified="2022-05-25" version="1">MKKLLTICSIWILFTAKVDLLSIPILFNIQDMVGLVTDISDIAMGRHDLTAGNLFRKKTDATMVAVNKLSDQISELTETINVKMDRMMTAVLEDVPGAIQLANLMRKLIDLISRVDKLYGDYLFYVRRSGNVTHYTIKDFGRVITSHKFGDVPDLLDQTYSLFIPGQLDHKDQSILDTMVSSLQLPCTLCNLHENEDLSHIFLKCPVYHPYREFYFVPLLPNKHLRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2EPC2</accession>
    <name>A0A8J2EPC2_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Similar to ANKRD13C: Ankyrin repeat domain-containing protein 13C (Homo sapiens)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HICCMSTLAB_LOCUS2404</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Acts as a molecular chaperone for G protein-coupled receptors, regulating their biogenesis and exit from the ER.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001117">
        <property type="protein sequence ID" value="CAG5077230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2EPC2"/>
    <dbReference type="OrthoDB" id="1585644at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005102">
        <property type="term" value="F:signaling receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006621">
        <property type="term" value="P:protein retention in ER lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.20:FF:000302">
        <property type="entry name" value="Ankyrin repeat containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021832">
        <property type="entry name" value="ANKRD13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055285">
        <property type="entry name" value="ANKRD13_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12447">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12447:SF25">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 13C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11904">
        <property type="entry name" value="ANKRD13_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 8" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="8">
        <location>
            <begin position="32"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="domain" description="Ankyrin repeat" evidence="10">
        <location>
            <begin position="148"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="287"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="287"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF11904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAG5077230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="445" mass="50791" checksum="565FA16CFA31557D" modified="2022-05-25" version="1">MDYPIHKCIFQGDIQLLSTLIRTHNIAEKDKHGNTPLHLAVMLGRKECIQLLLAHGAPLKVKNLAGWSPLAEAISYGDRQTISSLVRKLKQQAREQMEERRPDLVSALHKMGDFYMELKWDFQSWVPLVSRILPSDICRIHKSGASIRMDTTLVDFNDMRWERGDISFIFNGDQKPGKSLTVLDNKAKLYQRVRYEETELEIEDEVDVLMSSDIMAAQMSTKNITFVRAQTGWIFRADKREMVGPFNADFYQINGMVLESRKRREHLSEEDLQNNKAMMDTLTKGKSQGFINGETPNRRASLNPPPDSNISWETYLEVPAGECPLLGRSHVYKESSKAFRATVAMSPDFPLTVDMLLNVLEVTAPFKHFGKLRQFVQMKLPPGFPVKIDIPILPTVTAKITFQEFAFRNDINPDLFQVPSDYVEDPMSYYGAYMAMMMVLPASSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H0D2</accession>
    <name>A0A8J2H0D2_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS133</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030000784">
        <property type="protein sequence ID" value="CAG5071984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H0D2"/>
    <dbReference type="OrthoDB" id="7610447at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24664">
        <property type="entry name" value="Monjiviricetes_fusion"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="164"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5071984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="380" mass="41773" checksum="BAA0BF781061BAC2" modified="2022-05-25" version="1" fragment="single">MANKKRVRKRYNLRSKTRALNDTPEQSSNSDVEMRPAKSPPVRFQFKPRQWPIPPPSPTSRAKKKINQPGPSGLQQPPPVSDNESTDTASEVTENIANETNNKNAGAVGEKEKKKMPKSIEVPGPPNINSSSIEDSENEGLSDDPPPVNERHGISNSDGDDSEELRTDAEDSSEDDRRSEEGEAGDNENIRPPRAASATITPQIREITPNVCETRDRLSMQSDNILIFVNVQGKSYDEGSRELADVLQIPNNLNNAYCRSVVIPYKGDKRCIVAVPKYRKMDLVSTGDILNSTNHRVAILAGSQNMGGDCKSGTYSDEYGTWSGVVVDATFEITLTEYETALNSKTNEVLLRSGTRCEAGKLNCITSDGMSAFWSEVPKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H0R1</accession>
    <name>A0A8J2H0R1_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS209</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001058">
        <property type="protein sequence ID" value="CAG5073058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H0R1"/>
    <dbReference type="OrthoDB" id="7617070at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579">
        <property type="entry name" value="F5/8 TYPE C DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579:SF1">
        <property type="entry name" value="F5_8 TYPE C DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5073058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="268" mass="30741" checksum="CB8B1967D8CBD3BF" modified="2022-05-25" version="1" fragment="single">LHTGVNFRIPGSDQLQLVKASLICGTCDALARSDFLCHSRFNGNYGCSRCLSKGYTIREDGVFGNTHIYHFEGILIARDIANYDNYVLAAKKSKSAVFGVKCSSILNKIMPDMIRGTSIDIMHCVYLDVTKLLAKLWFDSSYRHKPWPLYAHRDIIDERLKKIKPPSFVKRMPRDLTTHSNHWKASEWKNFLFFYSLPLLEDLMGKDYLKHYVQLVSGIYILNQKSISPESINLSEELLTAFVAKFQSLYDVQITTFNLQLILKISAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H301</accession>
    <name>A0A8J2H301_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS273</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001114">
        <property type="protein sequence ID" value="CAG5073308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H301"/>
    <dbReference type="OrthoDB" id="7989680at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5073308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="176" mass="20680" checksum="67889CF739C8403A" modified="2022-05-25" version="1">MIHDKTFIIWDGTNSTNTTFKILQGLQQGTVNSPTLFSIYFSTLLSSFDLNKGDENKEIEKILETPDQQIYITNHNSVCLPPQATYFIYFDKKGIIQDSNNVPTIYHWGRNVANKRINLTSDMIANNKYHPVYSMALPERDKMDFYSLDERYWWLEDSCHRIKLKLRKLNGWSATW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H349</accession>
    <name>A0A8J2H349_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Carboxylesterase type B domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS513</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001114">
        <property type="protein sequence ID" value="CAG5073593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H349"/>
    <dbReference type="OrthoDB" id="19653at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carboxylesterase type B" evidence="2">
        <location>
            <begin position="23"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5073593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="126" mass="14666" checksum="70C893AFFE7D889D" modified="2022-05-25" version="1">MLRVRIDHYSKETSVVQKLFDTDLEGTALLEEAFYLFNAKILEKRGIAKPVSYPTEQIIHQRFIELWTNFAKTGNPNEETSELISVEWKPVDNSSDYNCLKISEDLCTIRVSDILHQLEEFAQKKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H583</accession>
    <name>A0A8J2H583_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Tubulin alpha chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">HICCMSTLAB_LOCUS1460</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="13">Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the tubulin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001116">
        <property type="protein sequence ID" value="CAG5075306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H583"/>
    <dbReference type="OrthoDB" id="7670677at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02186">
        <property type="entry name" value="alpha_tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.20:FF:000001">
        <property type="entry name" value="Tubulin alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1440:FF:000007">
        <property type="entry name" value="Tubulin alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.600">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.20">
        <property type="entry name" value="Tubulin/FtsZ, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="entry name" value="Tubulin/FtsZ, GTPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002452">
        <property type="entry name" value="Alpha_tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008280">
        <property type="entry name" value="Tub_FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000217">
        <property type="entry name" value="Tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037103">
        <property type="entry name" value="Tubulin/FtsZ-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018316">
        <property type="entry name" value="Tubulin/FtsZ_2-layer-sand-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023123">
        <property type="entry name" value="Tubulin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017975">
        <property type="entry name" value="Tubulin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11588">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03953">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01162">
        <property type="entry name" value="ALPHATUBULIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01161">
        <property type="entry name" value="TUBULIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00864">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00865">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55307">
        <property type="entry name" value="Tubulin C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="Tubulin nucleotide-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00227">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="10 13" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 13" id="KW-0493">Microtubule</keyword>
    <keyword evidence="7 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubulin/FtsZ GTPase" evidence="14">
        <location>
            <begin position="14"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="Tubulin/FtsZ 2-layer sandwich" evidence="15">
        <location>
            <begin position="213"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CAG5075306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="412" mass="46644" checksum="4D33F7A287B13F4D" modified="2022-05-25" version="1">MSSERTAFNDIDNIETFFAQTTQDKYVPRAIMCDLEPTVIDEFRNSEYQKLFHPEQLICGKEDAANNFARGYYTVGHKLLDSLTEKIRVLAENCNGLMGFLICHSVGGGTGSGFSSLLMEHLCYTFPKKTKLEFVIYPSPNMSTAVVEPYNAVLSTHLSLNENICAFMFDNEALYDVCRQKLDLDRPKYSNLNRLISQVVSSITASLRFDGSLNVDLSEFQTNLVPFPRIHFPVCAYSPVASTAKVDHNAMTIAELTSECFDKSNSLVKYNPQHGKYMACCLLYRGDVVPKDVNNAIACIKQKRTINFVDWCPTGFKVGINYQAPTAITNGDTASIERAVAMLSNTTAIREVWARLNRRFNLMYRKSAFLHWYQSEGMEMMEFAEARDDLAALELDYKEINSNTDQDTSYEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H5R7</accession>
    <name>A0A8J2H5R7_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Protein-lysine N-trimethyltransferase SMYD5</fullName>
            <ecNumber evidence="2">2.1.1.359</ecNumber>
            <ecNumber evidence="10">2.1.1.372</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">SET and MYND domain-containing protein 5</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">[histone H3]-lysine20 N-trimethyltransferase SMYD5</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">[histone H4]-lysine36 N-trimethyltransferase SMYD5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">HICCMSTLAB_LOCUS1752</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-lysyl(20)-[histone H4] + 3 S-adenosyl-L-methionine = N(6),N(6),N(6)-trimethyl-L-lysyl(20)-[histone H4] + 3 S-adenosyl-L-homocysteine + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:64456"/>
            <dbReference type="Rhea" id="RHEA-COMP:15554"/>
            <dbReference type="Rhea" id="RHEA-COMP:15998"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61961"/>
            <dbReference type="EC" id="2.1.1.372"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-lysyl(36)-[histone H3] + 3 S-adenosyl-L-methionine = N(6),N(6),N(6)-trimethyl-L-lysyl(36)-[histone H3] + 3 S-adenosyl-L-homocysteine + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:60324"/>
            <dbReference type="Rhea" id="RHEA-COMP:9785"/>
            <dbReference type="Rhea" id="RHEA-COMP:15536"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61961"/>
            <dbReference type="EC" id="2.1.1.359"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-lysyl-[protein] + 3 S-adenosyl-L-methionine = N(6),N(6),N(6)-trimethyl-L-lysyl-[protein] + 3 S-adenosyl-L-homocysteine + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:54192"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:13826"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61961"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:54193"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.359" evidence="2"/>
    <dbReference type="EC" id="2.1.1.372" evidence="10"/>
    <dbReference type="EMBL" id="CAJNRD030001116">
        <property type="protein sequence ID" value="CAG5075598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H5R7"/>
    <dbReference type="OrthoDB" id="438641at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140955">
        <property type="term" value="F:histone H3K36 trimethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140943">
        <property type="term" value="F:histone H4K20 trimethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045814">
        <property type="term" value="P:negative regulation of gene expression, epigenetic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10521">
        <property type="entry name" value="SET_SMYD5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044422">
        <property type="entry name" value="SMYD5_SET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46402:SF2">
        <property type="entry name" value="HISTONE-LYSINE N-TRIMETHYLTRANSFERASE SMYD5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46402">
        <property type="entry name" value="SET AND MYND DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SET" evidence="18">
        <location>
            <begin position="4"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00033038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00049789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00049806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="CAG5075598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="385" mass="44207" checksum="C12BC9D39BFF672B" modified="2022-05-25" version="1">MDEQNFQVRVINEEKGKGIFALRAFKEDEIIFEEKPVVCCQFSWNADYGYLACDNCMYPLENAEENVRRLTGKKNLVLPYPEYCEIKKELFAECPECGIKFCSNECLKEAFSKYHRILCSQTRGNKEGHPLEKLKETWKQMHYPPETATIMLLARMIAHVNQADDKSSVLAVYNNFCHKTVNEVHEIAHNLLGEKFIGQIDVLRELLEQTFNKDYVPQWFTPEGFRSLLALVGTNGQGIGTSAFSRWVKNVTALELPTDRRIQIDKFIDQIYDDMDEVVGTFLNNEGSGLYALQSTLNHSCSPNAVVEFPYSNSTLRIKAIRDIQPEDEICIGYLDECELERSRHSRQKLLSSLYLFVCQCDKCIAQADDSDVTSDDDYDHDMSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H6H1</accession>
    <name>A0A8J2H6H1_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS2847</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001117">
        <property type="protein sequence ID" value="CAG5078810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H6H1"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="33"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5078810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="416" mass="52201" checksum="E9F1320401797BB8" modified="2022-05-25" version="1">MRFGISTALVSIYTENLTPLFPKILKSSTIAAMLTLQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQHDRYNSYNYLENDVSCWRRYLYGCVTGLLIKSLLTAINDICTQLHFYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H6K5</accession>
    <name>A0A8J2H6K5_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similar to Gycalpha99B: Head-specific guanylate cyclase (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS2783</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001117">
        <property type="protein sequence ID" value="CAG5078582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H6K5"/>
    <dbReference type="OrthoDB" id="6127067at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1520.10">
        <property type="entry name" value="H-NOX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038158">
        <property type="entry name" value="H-NOX_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011644">
        <property type="entry name" value="Heme_NO-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024096">
        <property type="entry name" value="NO_sig/Golgi_transp_ligand-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07700">
        <property type="entry name" value="HNOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111126">
        <property type="entry name" value="Ligand-binding domain in the NO signalling and Golgi transport"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heme NO-binding" evidence="1">
        <location>
            <begin position="8"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5078582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="304" mass="34008" checksum="46F68FC093366044" modified="2022-05-25" version="1">MSVFFNPNIEVNVILDHLGQELISTACVGLLERAFRCLGNDLKAFLTTLDGVNDVVQHQSGTNTEAEFVCIATPDAVELHFTTDHPSIAYLLVGSLKGIARQFYNDKADVYILPDPYNTKFFSFFAISQNLPVQIGIKCIGNLSLVKPFRMAPTAIKSLRRRATRAAKRSPSQDEYSKEYKQAKKTLNRAIKASKAKLWKEICNDLDNDLWGKAYQIVAKRLGKASPEAPKSPAMMDSILYYTTILPCTSGTTYTTGATYAARQLLRPSFFVDASSYHVPHRLKRLPVFHGPVAHLNTNTFEFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H6R1</accession>
    <name>A0A8J2H6R1_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">AP complex subunit sigma</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HICCMSTLAB_LOCUS3013</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subunit">
        <text evidence="10">Adaptor protein complex 2 (AP-2) is a heterotetramer composed of two large adaptins (alpha-type subunit AP2A1 or AP2A2 and beta-type subunit AP2B1), a medium adaptin (mu-type subunit AP2M1) and a small adaptin (sigma-type subunit AP2S1). Interacts with CCDC32; the interaction is direct and mediates association of CCDC32 with adaptor protein complex 2 (AP-2).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <location evidence="2">Coated pit</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the adaptor complexes small subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001117">
        <property type="protein sequence ID" value="CAG5079444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H6R1"/>
    <dbReference type="OrthoDB" id="371463at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098588">
        <property type="term" value="C:bounding membrane of organelle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005905">
        <property type="term" value="C:clathrin-coated pit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030117">
        <property type="term" value="C:membrane coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098797">
        <property type="term" value="C:plasma membrane protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.60:FF:000004">
        <property type="entry name" value="AP complex subunit sigma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016635">
        <property type="entry name" value="AP_complex_ssu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022775">
        <property type="entry name" value="AP_mu_sigma_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000804">
        <property type="entry name" value="Clathrin_sm-chain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11753">
        <property type="entry name" value="ADAPTOR COMPLEXES SMALL SUBUNIT FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01217">
        <property type="entry name" value="Clat_adaptor_s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015588">
        <property type="entry name" value="AP_complex_sigma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00989">
        <property type="entry name" value="CLAT_ADAPTOR_S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0168">Coated pit</keyword>
    <keyword evidence="6" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 11" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0813">Transport</keyword>
    <feature type="domain" description="AP complex mu/sigma subunit" evidence="12">
        <location>
            <begin position="2"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00046780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR015588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAG5079444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="122" mass="14547" checksum="F1F78381E4166409" modified="2022-05-25" version="1">MNFDDDEKQKLIEEVHAVVTVRDAKHTNFVEFRNFKIVYRRYAGLYFCICVDVNDNNLCYLEAIHNFVEVLNEYFHNVCELDLVFNFYKVYTVVDEMFLAGEIRETSQTKVLKQLLMLNSLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H764</accession>
    <name>A0A8J2H764_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to SDR-1: Farnesol dehydrogenase (Aedes aegypti)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS3216</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5081196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H764"/>
    <dbReference type="OrthoDB" id="1933717at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43115">
        <property type="entry name" value="DEHYDROGENASE/REDUCTASE SDR FAMILY MEMBER 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43115:SF4">
        <property type="entry name" value="DEHYDROGENASE_REDUCTASE SDR FAMILY MEMBER 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5081196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="163" mass="17846" checksum="57789F5A2AFDFBFC" modified="2022-05-25" version="1">MDRWRGKIAVVTGACSGIGRAITVSLLCNEINVIGLDINGKEFPKIKESVSSASSKAGAFHGIQCDVSRDKDISDAFEVVDKQFSGVDIMINCAGVIDYRTIYDADRESFERLLNINVLAVATCIRAAIKSMRDRGVQGHIININRLNPTSVHNILIKIIKQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H7H0</accession>
    <name>A0A8J2H7H0_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Similar to Arntl: Aryl hydrocarbon receptor nuclear translocator-like protein 1 (Mus musculus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HICCMSTLAB_LOCUS3285</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5081433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H7H0"/>
    <dbReference type="OrthoDB" id="7788762at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050933">
        <property type="entry name" value="Circadian_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001067">
        <property type="entry name" value="Nuc_translocat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013767">
        <property type="entry name" value="PAS_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23042">
        <property type="entry name" value="CIRCADIAN PROTEIN CLOCK/ARNT/BMAL/PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00989">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14598">
        <property type="entry name" value="PAS_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00785">
        <property type="entry name" value="NCTRNSLOCATR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="PYP-like sensor domain (PAS domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="PAS" evidence="7">
        <location>
            <begin position="52"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="7">
        <location>
            <begin position="260"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="136"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="440"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="137"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="440"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="470"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG5081433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="837" mass="92758" checksum="42BA296616F68C3E" modified="2022-05-25" version="1">MMAALVPNIASSSKRHDKISILRLAAAYLRSNFAIGPGIRDFIPLEYSDIDLEENFVDGFDGTGSFLLVVTITGNIVYISPRVEGPLGYSPVEMMGKSIFSYVHPEDHSELSKALTPDEYVQPVKKIAYYNEDCSTNEETTNTSSNSTAVSTITNNNNSNINHNSNSNFKEQRRSFYVKIAQRTNSRGEHTQFKCFHVSGVLRLADFLRKKNNSENSPAVAATSNDIIFTGIAKVIHKRITELSLYEANKQEYITRHLVDGRIVFSDHRIALVAGYMSEEVSGVNAFRFMHKDDVMWAITALRQMYDRREGFGTSCYRLLSKSGKFIYLRTHGWLEFDNKTGTFESFICVNTLVEKDEGENLIKELRNRFSATVTQISATSAGTLTVASSSSVSALSPSLSSSSSTTSSSSSYFSPCSPPKFGLSPDLSSSSAAVTTTAPTAVVPTSTTSSSSLSTATPSTPASVGTLKKSPSQSEQNVEDPTQLEDAIYQLISTLKSPTTASNLSPPTSDIECNPEIAETTSISSAMTSAVPTPSSGASSNLYKLFSADNNISKVENNKFEDDTSHKNKRIKTELSNSIDSSINQLNGYDNNRKKKINCHNSTKLLNNSEKKLTDDKLIINDKMLSLNSQNLLFSGNKINNRLMKNNVDINNDDGEDNLKQSNNIYLKYNNGNVNKNEQEATTCVKIELNGIGIKRPGEDDKRKDKRRHISISSSDQVNNLIVVKNNELIVNKLKIQEKKFSGDDNDDDRVIHVNQSNNLIIDNNQVDNDKKAIIDNDTLFNIDNHINGQSEQFGQVKLIYNEKDCETIKNYQQLKSQCQSNIINNFKDDSNDYTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H7N7</accession>
    <name>A0A8J2H7N7_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Similar to CG4928: UNC93-like protein (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HICCMSTLAB_LOCUS3438</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the unc-93 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5082025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H7N7"/>
    <dbReference type="OrthoDB" id="78663at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055120">
        <property type="term" value="C:striated muscle dense body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015459">
        <property type="term" value="F:potassium channel regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006937">
        <property type="term" value="P:regulation of muscle contraction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043266">
        <property type="term" value="P:regulation of potassium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010291">
        <property type="entry name" value="Ion_channel_UNC-93"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051951">
        <property type="entry name" value="UNC-93_regulatory"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19444:SF13">
        <property type="entry name" value="PROTEIN UNC-93 HOMOLOG A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19444">
        <property type="entry name" value="UNC-93 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05978">
        <property type="entry name" value="UNC-93"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="94"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="131"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="159"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="183"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="220"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="295"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="63"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG5082025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="322" mass="34586" checksum="AA63A8AD9FCC94B9" modified="2022-05-25" version="1">MVASQNDDRRGGGESPPTNGASATPAGDSSPPDEHETAVYTVSVTGVGYRNEGYKEDGADGIPPEPTKPPALPAPEDDTQSRKFKLSRSEKWRILKNIGTVSIAFMVQFTAFQGTANLQSSINASDGLGTVSLSAIYAALVLSCIFVPTFLIKRLTVKWTLCLSMLCYAPYIGSQFYPRFYTLVPAGVLLGLGAAPMWAAKATYLTQVGGVYAKLTDQPADAIVVRFFGFFFLAWQTAELWGNLISSLVLSEGEFGGEGDINSTRYKKLKSCGANFCVIGNGADESLKRPPDSEIYEISAIYLTCVIVAVIIVALFVDPLSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H7R0</accession>
    <name>A0A8J2H7R0_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Odorant receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HICCMSTLAB_LOCUS3681</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Cell membrane</location>
            <topology evidence="1 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the insect chemoreceptor superfamily. Heteromeric odorant receptor channel (TC 1.A.69) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5082906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H7R0"/>
    <dbReference type="OrthoDB" id="6597368at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005549">
        <property type="term" value="F:odorant binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004984">
        <property type="term" value="F:olfactory receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004117">
        <property type="entry name" value="7tm6_olfct_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21137">
        <property type="entry name" value="ODORANT RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21137:SF35">
        <property type="entry name" value="ODORANT RECEPTOR 19A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02949">
        <property type="entry name" value="7tm_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 10" id="KW-0552">Olfaction</keyword>
    <keyword evidence="8 10 11" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="9 10" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="29"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="116"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="154"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="254"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU351113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAG5082906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="370" mass="42529" checksum="65D9B2243087EE02" modified="2022-05-25" version="1">MIKFILTFLSASGMWKPRGWHGIKAFLYYIYQFTVFFCNFLFIISSILIIELKDINVEELIDNMSLLLAIINARQKMSLIIFERRSIEYISDKLEKSPFKSCDSIEKAISTKFDGIVRNVFICYSITIGAMLVYCGSRFTEVNPSETLPFNGWFPYNYSSPTVYWLTAAFQVIAINITNGIDLLMDLLLSSILCSMCGQIHLLKHRFKVMLEALNVMTSKNDGSDMATTEKLMISEWVEYHIDLVNLIKYTNTVFSNVILLQYTVSSVILCAVSFLMSRTEIMSMTFAGFLGYLITFNTQIFQQCYCAHMLTHEATNWPSLSNNTRKSVMIIMYKCHKPIMITSSFFVILSLDSYTKIVKLAYTIFNVLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H866</accession>
    <name>A0A8J2H866_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Similar to Luciferin 4-monooxygenase (Photuris pensylvanica)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HICCMSTLAB_LOCUS3916</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5083738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H866"/>
    <dbReference type="OrthoDB" id="10253869at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016405">
        <property type="term" value="F:CoA-ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05911">
        <property type="entry name" value="Firefly_Luc_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.30:FF:000007">
        <property type="entry name" value="4-coumarate--CoA ligase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096:SF149">
        <property type="entry name" value="AMP-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="233"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="6">
        <location>
            <begin position="29"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="7">
        <location>
            <begin position="442"/>
            <end position="518"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG5083738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="530" mass="59578" checksum="63BB6672BDBD68D8" modified="2022-05-25" version="1">MKEKITVCGPPSFEIPNISFGQYIVDRLRQSPLHVVQVDAKTGETLTNYEVLEKSVKLSKYLEQKGIKVGDTVAISSENILNYFIAVFGTIYRGSAIAPMNPDYLEDEIKRCCKISRPRLIFVSLKTRDIIFHATKSLPWKIELIQLETLDSILSNFDNNNYDNNFYQNFQLESVKKPKEQEIVILYSSGTTGLPKGVMLSHHNALTISYTFRSRQFREFQDKSIDLIFLPFYHGYGFAMMMSIITMGTTAVVMKSFEPELFCRAIEKFKVNTLPLVPPIMIFLAKSPIVSKYDFRSLKEIICGAAPLSKEVREAVKSRFPWAKIRTGYGMTELSVAVCLSDRNSQKSETIGNLTSGVCCKVIDPEISKSLKAYETGELCFKGDHVMLGYRDDPEATGQTIDHHGWLHTGDLGYFDHDGDLFIVGRLKELIKSKGFQIAPAEIENILLSHPDVNDAAVIGKYDATGDQVPVAFVVKKSQSDVTGEQLRKFVDDKVSIQKHLRGGVKFIDAIPKSPAGKILRLQLQLNSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H8F5</accession>
    <name>A0A8J2H8F5_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS3067</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001117">
        <property type="protein sequence ID" value="CAG5079657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H8F5"/>
    <dbReference type="OrthoDB" id="7676225at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005312">
        <property type="entry name" value="DUF1759"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331:SF1">
        <property type="entry name" value="GAG-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331">
        <property type="entry name" value="PHD-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03564">
        <property type="entry name" value="DUF1759"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="383"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="383"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5079657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="434" mass="49533" checksum="DE3A3E9094FBC4F1" modified="2022-05-25" version="1">MNEPCSEIDAIQIVQAEEMKVHKSWWILDPFIPDLFTNRHREQDFLKLFIEKPFSTPEKNYSSSENDFEDSGSTRSDELFFDCDSSHTSDSEDDSSSNSDENDELNRLSMTAVEAAQNQGYRLWHDITNLNSLIFEMYPEVLQHEYHTGNRYTTAHASYTTLETRIATRKDAIQEEIDARDAEQAQNTLAMHSTAYMGGSSGTGLPKIKLHTFSGDFKRWGSFSQLFSDIVIDNALLKNSQKMHYLKTFTEKEAHQLIGNMPSTDDSFEPAWNLLKSRYLNPRRVVASHLEDLLVGESVPARSAAKLDALLLSNQKALDSIKAQGIPVNNWDLMIIHLTLRHLPPAVREDWETSLGLTDIMPTYTQLHEFLKLKVRAWENLEPASEPKKQPENHKSGGSRSDKQPRTKSSYTAAQYKGKPRRNCPLCPEEHYMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H960</accession>
    <name>A0A8J2H960_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Similar to BTBD2: BTB/POZ domain-containing protein 2 (Homo sapiens)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HICCMSTLAB_LOCUS3811</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5083342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H960"/>
    <dbReference type="OrthoDB" id="636773at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022008">
        <property type="term" value="P:neurogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18487">
        <property type="entry name" value="BACK_BTBD1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.420:FF:000004">
        <property type="entry name" value="BTB/POZ domain-containing protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.820">
        <property type="entry name" value="PHR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011705">
        <property type="entry name" value="BACK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012983">
        <property type="entry name" value="PHR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038648">
        <property type="entry name" value="PHR_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45774:SF3">
        <property type="entry name" value="BTB (POZ) DOMAIN-CONTAINING 2B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45774">
        <property type="entry name" value="BTB/POZ DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07707">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08005">
        <property type="entry name" value="PHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00875">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="3">
        <location>
            <begin position="79"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG5083342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="488" mass="54725" checksum="67057D6D0B6F6E4A" modified="2022-05-25" version="1">MSQIIRRHHLLAEEFKLLQLPSNSVNTLHLEARPHNDPPAEVHQAPARQLASSQLYNWQGSKTTMKERFAFLFNNEILSDVRFLVGRVGQQQRIPAHKLVLSSGSAVFDAMFNGTLATASAEIEVPDVEPAAFLAVLLFLYTDEIQIDPDTVMTTLYTAKKYAVSPLEKHCVEFLRSHLTHDNAFLLLTQARLFDEQQLAAVCLDTIDKFTTDALNADGFTDIDIDTLMVVLERDTLRVRESKIFQAVVRWSEAECVRQQLPVTPENQRSVLGRALSLVRFPLMSVEEFAMGPAQCGLLTDREVVSLFLYFTVNPKPAVGFEAMPRCRMMGKELTVCRFQQTDSRWGYNGTSDRIRFSVDRRIFLVGYGVYGSVHGPAEYEVLIELTHTASGKTIATNSTSFSCDGSNYTYRLMFKEPIEIIANTIYTASATFKGPDSHYGTKGLRCVSVDCFNSGKNIIKFQFSFAAGNNNGTSIEDGQIPELIFYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H998</accession>
    <name>A0A8J2H998_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Similar to O4: Probable protease inhibitor Egf0.4a (Microplitis demolitor bracovirus (Isolate Webb))</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HICCMSTLAB_LOCUS4816</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the serine protease inhibitor-like (TIL domain-containing) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5088371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H998"/>
    <dbReference type="OrthoDB" id="7695409at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030414">
        <property type="term" value="F:peptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19941">
        <property type="entry name" value="TIL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036084">
        <property type="entry name" value="Ser_inhib-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051368">
        <property type="entry name" value="SerProtInhib-TIL_Domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002919">
        <property type="entry name" value="TIL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23259:SF70">
        <property type="entry name" value="ACCESSORY GLAND PROTEIN ACP62F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23259">
        <property type="entry name" value="RIDDLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01826">
        <property type="entry name" value="TIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57567">
        <property type="entry name" value="Serine protease inhibitors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0646">Protease inhibitor</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035182379" evidence="5">
        <location>
            <begin position="21"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="domain" description="TIL" evidence="6">
        <location>
            <begin position="236"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="303"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="305"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAG5088371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="350" mass="40097" checksum="A513DA8B177980E0" modified="2022-05-25" version="1">MLPIYSKILLLFVCISWIEAIPNYKCDTNEYYNYKDGGDATCQDPDGSSFDVSKNTNGCHCLPGFVRNEHYECVKLEECPEVTNEPSSNPEDSYNIDPNNPETIKLLREIFGTPEDWYAKKNQDKVDDEYPTLRKNIQKVLIEPKNSGYVNQHTDFDLDDPETQKIIQQIFGPNNYNLHENNQDEVDVNSPEFKKNVEKIFDSPPKDYGIEAIPTGDVDEDYLNLNLKNTVAPIVCPGNASFSEIIPVCEAYCDDPRPTLCYRYESDGCLCIEGYIRNATSDCIRIEDCPNIKLEYTQELDDNSYDEKDWPEPEPPKIEDITGGLSDEEWKKRLEEIFGTPDETPVETVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HA51</accession>
    <name>A0A8J2HA51_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Similar to Fbxl7: F-box/LRR-repeat protein 7 (Mus musculus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HICCMSTLAB_LOCUS4527</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5087493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HA51"/>
    <dbReference type="OrthoDB" id="423607at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031146">
        <property type="term" value="P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057207">
        <property type="entry name" value="FBXL15_LRR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006553">
        <property type="entry name" value="Leu-rich_rpt_Cys-con_subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13318:SF50">
        <property type="entry name" value="F-BOX_LRR-REPEAT PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13318">
        <property type="entry name" value="PARTNER OF PAIRED, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25372">
        <property type="entry name" value="DUF7885"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00367">
        <property type="entry name" value="LRR_CC"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="F-box" evidence="3">
        <location>
            <begin position="101"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="67"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="67"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG5087493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="462" mass="51997" checksum="EAF0F65E9C7178AA" modified="2022-05-25" version="1">MDNSCPLLFNSFGDSITDRTINHQLQKLSLYSPASDSIDLGYHTLDNNPCRSSSSPTVITNVNPRHHYQHHHQHQHQHQHQHQHQHQHQHQHQQIYKRIANPNLCQLDDTILLKIFSWLSTRERCTLAQTCRRLWEIAWHPSLWKEVEIRYPQNATTALRSIARRGCHSCIRRLVVEGATGFSGLFSMLPFASLTSLVLRHSRRVTDPNVTTILDNCVHLKELDLTGCVNVTRAYSHVGSTQLESLDLSDCHGVDDSGLVLTLSQMSQLTFLYLRRCIRITDASLISIASYCTCLRQLSVSDCTRITDYGVRELAARLGPSLRYFSVGKCDRVSDAGLLVVARHCYKLRYLNARGCEALSDIATCALARGCPRLRALDLGKCDIGDPTLEALSTGCPNLKKLSLCGCERVTDAGLEALAYYVRGLRQLNIGECTRVTKVGYRAVKSYCRRCVIEHTNPGFSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HB43</accession>
    <name>A0A8J2HB43_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RNase H domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS5589</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5090332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HB43"/>
    <dbReference type="OrthoDB" id="6369833at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5090332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="73" mass="8553" checksum="C3C0CDAD44D469AD" modified="2022-05-25" version="1">MTHSHIMTKEPSPQCQRCGEILTIKHILIECNNYNPERRKTKLPNNMKSCLDDHSGCLKTLQFIKIIKLFKEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HC14</accession>
    <name>A0A8J2HC14_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similar to SIS8: Probable serine/threonine-protein kinase SIS8 (Arabidopsis thaliana)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS6704</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5093263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HC14"/>
    <dbReference type="OrthoDB" id="7700972at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051681">
        <property type="entry name" value="Ser/Thr_Kinases-Pseudokinases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE TNNI3K-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="359"/>
            <end position="648"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5093263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="658" mass="75040" checksum="EDD9A80541360310" modified="2022-05-25" version="1">MAFVKIHYNCDEILLPLTTGGNLKLSVLKQYFPSAVGLTYIKDGHSFGVKIKNPIISKKRKLVEEMLSKLPAYDQQILGSSKSKNTILNNPYISMLQFMTKPGYSTSASTSTPQGTSSKKQELISYRKILVGWLRNQDGIFKQVLKPLGGVKQLSLEVGKNYTVEDITVLATQEFEKNSDLSFDKYKVLLGHFNGSVISNFKNGMDQETKRFVFYLLTFLKNEPSMVQDISEPSKGKLPFQYTKDKSIACVQKEDLYQMRYDDLYRLTIDEFDPFKNGFRVAEISTGGKILLNIYTDPENLQREFLFPAADIIEDEEDSNNNHYIIHDVDELNGYCENKLGVGVITNCKDRCKFVFVWYKDEKLFEQGQFRYWISGIDVSSTYRCVIKCQSMDQEISSGNFKYNDDENSSKSTLMDNALCILKKAQNSTITSIKKEKLIIFKELLGAGAQGKVKKGRWNGTDVAVKTIILSESNLKLACREIKILEVVRHPNFIQLMAYCTERDRIHLIMELCESTSLNDIRFVKICDLGLSKFKKMTFSLKSTIGRTRFVRGTPLYMAPELLLENSEANVYSDVWALGCTLVELYSEKTIWGDTNSEDGLKMILRQKKIPDLSCIPQYLRSVLSKCFSYDCQNRPSVLDILECYANLGFIKSEVLAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HCF6</accession>
    <name>A0A8J2HCF6_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Similar to cnpy4: Protein canopy 4 (Danio rerio)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HICCMSTLAB_LOCUS6959</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the canopy family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5093623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HCF6"/>
    <dbReference type="OrthoDB" id="6020060at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021852">
        <property type="entry name" value="DUF3456"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15382:SF8">
        <property type="entry name" value="CANOPY B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15382">
        <property type="entry name" value="CTG4A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11938">
        <property type="entry name" value="DUF3456"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035289602" evidence="3">
        <location>
            <begin position="18"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="4">
        <location>
            <begin position="183"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAG5093623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="526" mass="60146" checksum="F4E6A36592C43045" modified="2022-05-25" version="1">MIRTLLLNFLLFTTIYASPEEDEGVKYANKCEVCKVFSMELEARLDETGKTHDVLEVGYSLDDVAPKKKKQYKQSELRLVESLEDICERILEYNIHKERDDSTRFSKGMSQTFKTLHGLVDKGVKVELGIPYELWDKPSVEITTLKTQCEDMLENHESDIEEWYFNYQGKVPLERYLCSERVLVDDDDSCLKEKGDTETDNFFPYLVQFYTIVPCGGILITPDWVLTAAQCLHNKRNSILVNVVGTNEIPGEPIGVKATFIHPKFNMYSKVHDHRFNIALMKLYRPFNLQPLGFLNNTAGMLVNIGATKSINTYNCCFIYGWDSIISSTIRVFTKAIKTISVQPRDKEACVNKINDVNIVCASGESRKQCAGNPGSPIVCNEPNGDNRVLGIASWTNFSLQCDDSSTYLNLTSFRSWINNLVSMDFEKNNSPGNYNSTTSLKVQVKYFYNTPKTPYYRKIHNFTTSTTKNTTKRKKYQDIERSDKDEGTTEDELSKIFPLYQASSSNLIYPIYFLLILGHICSFNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HCR7</accession>
    <name>A0A8J2HCR7_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">hydroxymethylglutaryl-CoA lyase</fullName>
            <ecNumber evidence="3">4.1.3.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HICCMSTLAB_LOCUS5102</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>(3S)-3-hydroxy-3-methylglutaryl-CoA = acetoacetate + acetyl-CoA</text>
            <dbReference type="Rhea" id="RHEA:24404"/>
            <dbReference type="ChEBI" id="CHEBI:13705"/>
            <dbReference type="ChEBI" id="CHEBI:43074"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="4.1.3.4"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Metabolic intermediate metabolism; (S)-3-hydroxy-3-methylglutaryl-CoA degradation; acetoacetate from (S)-3-hydroxy-3-methylglutaryl-CoA: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HMG-CoA lyase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.3.4" evidence="3"/>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5089097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HCR7"/>
    <dbReference type="OrthoDB" id="1905920at2759"/>
    <dbReference type="UniPathway" id="UPA00896">
        <property type="reaction ID" value="UER00863"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004419">
        <property type="term" value="F:hydroxymethylglutaryl-CoA lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046951">
        <property type="term" value="P:ketone body biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006552">
        <property type="term" value="P:L-leucine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07938">
        <property type="entry name" value="DRE_TIM_HMGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000071">
        <property type="entry name" value="Hydroxymethylglutaryl-CoA lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000138">
        <property type="entry name" value="HMG_CoA_lyase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043594">
        <property type="entry name" value="HMGL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000891">
        <property type="entry name" value="PYR_CT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004283">
        <property type="entry name" value="PRK05692.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42738">
        <property type="entry name" value="HYDROXYMETHYLGLUTARYL-COA LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42738:SF7">
        <property type="entry name" value="HYDROXYMETHYLGLUTARYL-COA LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00682">
        <property type="entry name" value="HMGL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01062">
        <property type="entry name" value="HMG_COA_LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50991">
        <property type="entry name" value="PYR_CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyruvate carboxyltransferase" evidence="7">
        <location>
            <begin position="1"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG5089097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="252" mass="27215" checksum="F8A5008AA9ACF778" modified="2022-05-25" version="1">MQDNATVFKSIDKKSEINYPVLVPNLKGLQSALEVGVKEIAIFGAASESFSHKNINCSIEESIKRFKEVILEAQKNNIKTRGYISCIAGCPYEGNIKASAVAKVADAMLQLGCYEISLGDTIGVGTPKKIINVLNEIKHLSKLGNFEEFALHCHDTYGQALANTYASLEYGVRIFDASVAGLGGCPYAAGASGNLATEDLLYLLSEQGFKTDINLNEIIEIGDWISGELGRTNMSKVGLATIAKEKLKKKSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HCU5</accession>
    <name>A0A8J2HCU5_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Similar to SLC41A1: Solute carrier family 41 member 1 (Pongo abelii)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HICCMSTLAB_LOCUS7028</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLC41A transporter family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5093702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HCU5"/>
    <dbReference type="OrthoDB" id="5791097at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:monoatomic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.357.20:FF:000001">
        <property type="entry name" value="Solute carrier family 41 member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.20">
        <property type="entry name" value="SLC41 divalent cation transporters, integral membrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006667">
        <property type="entry name" value="SLC41_membr_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036739">
        <property type="entry name" value="SLC41_membr_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045349">
        <property type="entry name" value="SLC41A1-3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16228">
        <property type="entry name" value="DIVALENT CATION TRANSPORTER SOLUTE CARRIER FAMILY 41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16228:SF7">
        <property type="entry name" value="SLC41A_MGTE INTEGRAL MEMBRANE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01769">
        <property type="entry name" value="MgtE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161093">
        <property type="entry name" value="MgtE membrane domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="125"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="196"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="237"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="276"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="309"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="340"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="436"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="467"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="503"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="domain" description="SLC41A/MgtE integral membrane" evidence="11">
        <location>
            <begin position="162"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="SLC41A/MgtE integral membrane" evidence="11">
        <location>
            <begin position="374"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="42"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="46"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAG5093702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="538" mass="58949" checksum="CC02E370329B37D2" modified="2022-05-25" version="1">MFESSQEDQQLTRQYFDKQPVQPVIYNSVKFDVEDGPCKEPLLPSSKRNSYRMTPTGGRSRTVSETNATAVSIPLTESADECHEITILDEATEGGRLPDVVAESRFRDDSGEEQLESYLAITIQVFIPFLVAGLGMVGAGLVLDLVQHWIVFEKVNELMILVPALLGLKGNLEMTLASRLSTQANLGHMDAPKQQWYMIVGNLVLIQCQAIVVGFLGSVVAILMGAVKNGTVSLDHVYLLCASSLVTASLASFVLGLITAGVIVFSRHCNINPDNVATPIAASLGDITSLALLSWISTILYEAIGKQDWLAPLIIACYILVTPLWVWIAKRNKYTNDVLYSGWTPVMVAMLISSCGGLILDFMVSRFETLTVFQPVINGVGGNLVAVQASRISTALHKQADLGTLLIPPGHTHPVIFITPIANFFGKGHHSRTTRVLMAMVIPGHIIFIYMIKYMKDGDTALTPLFVFVYLCAAMLQVAALLYIAYIMIHWMWKRKIDPDNSAIPYLTAMGDLLGISLLAIAFQFLYLVGDQDYDGAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HDE0</accession>
    <name>A0A8J2HDE0_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Similar to TMCO4: Transmembrane and coiled-coil domain-containing protein 4 (Homo sapiens)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HICCMSTLAB_LOCUS6477</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMCO4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5092958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HDE0"/>
    <dbReference type="OrthoDB" id="277931at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007941">
        <property type="entry name" value="DUF726"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17920:SF3">
        <property type="entry name" value="TRANSMEMBRANE AND COILED-COIL DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17920">
        <property type="entry name" value="TRANSMEMBRANE AND COILED-COIL DOMAIN-CONTAINING PROTEIN 4 TMCO4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05277">
        <property type="entry name" value="DUF726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="128"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="166"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="285"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAG5092958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="527" mass="57994" checksum="6072A466FF58476B" modified="2022-05-25" version="1">MDRSRKHNHLDISESGTYAYLSICSISLSELFPGEWNHEFNIKYIKGLCEHLKAPEKVSAVMLVLVDGNSGHTVEPYIELLLQEPNLNKKPILIVQDAVLYAVNMTHDREEKDAESKKRDKIRKIKRYTSIGIATVAGGTLIGLTGGLAAPFIGVGVGTILGGASAAALTSTAGVAIIGSIFGVAGAGLTGYKMNKRVGKVEEFSFEPLSRFCNTDQQLHVAIAVTGWLKNQDIDNVRKPWKCLAISREQYALRYETKYLVEMGQALEYILSMAVSFATQEALKYTILAGIMSAIAWPAALLSIASVIDNPWSVCCRRSSEVGKHLAHVLLSREHGKRPVTLIGYSLGARVIFYCLRELAEVGNAEGIIQDAIMLGAPVTDKSNQWEKCSRVVAGKIINGYCNTDWLLRFLYRTLSMATGVAGLAEVKCPRVTNIDLTSIISGHTEYSDKLVEIMEFVGVRTRSADVLDDEGVLKKSTSDYTEMGRSRKSTYSNKKLRIRASKSDECLNILPMTQHGNKLMCWSNVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HDP6</accession>
    <name>A0A8J2HDP6_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS5692</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5090602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HDP6"/>
    <dbReference type="OrthoDB" id="415822at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5090602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="139" mass="15552" checksum="8F474C2FE79F246E" modified="2022-05-25" version="1" fragment="single">QYLNIEGKTWFADKTGTAAIWIVNTKNVTVNNSGSGAGFVWIQTPTTYLMSVYLSPNEGISKLDPEALRASLAKSCSTLQNNPTPDTRSETERTVLNIMKEISAACDASMPRLKNRSFHRPAYWWSTDIAKLRKICHQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HDR9</accession>
    <name>A0A8J2HDR9_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Similar to Vps11: Vacuolar protein sorting-associated protein 11 homolog (Mus musculus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">HICCMSTLAB_LOCUS6339</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Late endosome membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Lysosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the VPS11 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5092725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HDR9"/>
    <dbReference type="OrthoDB" id="26184at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030897">
        <property type="term" value="C:HOPS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007032">
        <property type="term" value="P:endosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048284">
        <property type="term" value="P:organelle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007033">
        <property type="term" value="P:vacuole organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006904">
        <property type="term" value="P:vesicle docking involved in exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16688">
        <property type="entry name" value="RING-H2_Vps11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000258">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 11 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057308">
        <property type="entry name" value="CHCR_PEP5_VPS11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000547">
        <property type="entry name" value="Clathrin_H-chain/VPS_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057307">
        <property type="entry name" value="PEP5_VPS11_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024763">
        <property type="entry name" value="VPS11_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23323">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23323:SF24">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 11 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23341">
        <property type="entry name" value="PEP5_VPS11_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23356">
        <property type="entry name" value="TPR_PEP5_VPS11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12451">
        <property type="entry name" value="VPS11_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50236">
        <property type="entry name" value="CHCR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0458">Lysosome</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="repeat" description="CHCR" evidence="12">
        <location>
            <begin position="468"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="repeat" description="CHCR" evidence="12">
        <location>
            <begin position="642"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="14">
        <location>
            <begin position="883"/>
            <end position="921"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1084"/>
            <end position="1133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="1109"/>
            <end position="1123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CAG5092725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="1133" mass="129029" checksum="FF9BADE2AE846EB2" modified="2022-05-25" version="1">MILNLPYGTSSKFLHERLQMPTIKNVVHEIAIKFFNTLNDKEPLKDVAKTTNQNPCFKHKVLNQIIINQQPKNISKPVNDIKYLTSATSGNGSLIFSDSLGNIHVVKRTYQVSTFKAYEITCTLTHQVPHTSYLFTIGEDDPGCNPTIKVWNFSKLDKQENPTCIRVSRAIPSFRAVPATAMYIHPSLSMMAVGFSDGSVMLYRGDVTRDRKNKIKVIKDSNTAVTGLEIRSTGKQNHLFVATTLNVYLYNITAKDKEVKTVLDNMGCAPGCSVLAETNQDSHFMIARNDAVYCYTLDGRGPCYAIEGQKVMLDWFRGYLVIVAKESAGAPSRSGASGSGVGVSRSTTISAKPNTIEPIPPGVDKHQITVLDIQNKFIVFSASMISISAIVSEWGGFFILSGDNKLYHLDEKDLQLKLALLFKKNLYDVAIRIAKSQQYDSEGLVDIFRQYGDHLYAKGDHNGAIEQYIRTIGKLEPSYVIRKFLDSQHIDNLTTYLQALHKQGKATEDHTTLLLNCYTKLNQTDKLKQFIMTKDREVDFDVEIAIKVCRSASPEDALLLARKHKKHEWFLRIQIEDKQEYKSALEYMETLEFEEAEMMMKKYGKILIENVPAAATEFMKKLCTNYRPVTLDRPLIDQNVDLDEQTERANPEDFIHLFLNNSERLVEFLEYLVKCDTKWSTLVYNTLVEHYLHVWEAQEADVTKLQYEQKVIRLLQNSEACYDKDQILILCHQHNFRRGLLYLYEERKLYQEILQYHLREADDESVLSTCRRFGHQDPNLWVQALWSVARNRKASPKLLADILTFIAAEKLLSPLMVIDALSTSLNCTLGDVRSYLNSVLKTEHDQTIADHELVEKYRKDTIKLREQIDVIKNSTIIFQGSRCSACHHQLELPSVHFMCTHSYHQHCFQSFSENENECPACLPNNKKLLDIIRAQEASRDLHETFHSLLDRAEDPFSLVADYFGRGVFKKLMVITDADAEKPLIPGATNTAALNPIVRNSEDKEIKERAYGTSEARIRLTEGKSKDVDERGRYAMSLEANISSRERRSSPVRIREALIVNSSPKNSPGKNFVVPKTPIVPVNAVPADYDEKNNPFAEEATEETKSTNPFDEDDDKDDDDDDDDYNKNLNPFSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HE18</accession>
    <name>A0A8J2HE18_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Similar to VAT1L: Synaptic vesicle membrane protein VAT-1 homolog-like (Homo sapiens)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HICCMSTLAB_LOCUS6553</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5093052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HE18"/>
    <dbReference type="OrthoDB" id="203908at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08275">
        <property type="entry name" value="MDR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002364">
        <property type="entry name" value="Quin_OxRdtase/zeta-crystal_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052100">
        <property type="entry name" value="SV-ATPase_mito-regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44054">
        <property type="entry name" value="SYNAPTIC VESICLE MEMBRANE PROTEIN VAT-1 HOMOLOG-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44054:SF2">
        <property type="entry name" value="SYNAPTIC VESICLE MEMBRANE PROTEIN VAT-1 HOMOLOG-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13602">
        <property type="entry name" value="ADH_zinc_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01162">
        <property type="entry name" value="QOR_ZETA_CRYSTAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="4">
        <location>
            <begin position="75"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="418"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="28"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="425"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="443"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAG5093052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="470" mass="52584" checksum="37512CE37381FDD7" modified="2022-05-25" version="1">MAEEKTENSPSAEGEKKINETNSPTKTEQSDGKDIQIEEKKIEENNESEKVNENDDSKQTSEPKSMRAIVLNNFGSLKNVKVFKKPEPTPSQDEVLIKVKICGLNFQDLMVRRGTFDLPSKPPFIMGSECAGEIEMIGEGVTNFKVGDRVVALPDYKGWAELVTVPETAVFKLPENMSYSDAAAITMNYVVAYIILFDLSCLTPGKSLLVHSAGGGVGQAVVQLAKTVKDVKVFGVCSKSKHEELKSENNIDYLLERGSDYCSEVRKVLPEGVDIVLDCMYGEEYNKCYSLLKPMGRYILYGSNNLFTGETKSFFSVARSWWQVDKISPIKLFDDNKTITGFNLRHLMHQQGGHSFVKNAVDQVFKLWADGYIKPKIDSTWALENVTDAMQKMHDHKNIGKIVLDLSLEPKIKVAPVNKGKVKDKKNANQDEKQESQTEPEENEKKTEAEPKNDQNEDASDNAVKENESS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HEJ2</accession>
    <name>A0A8J2HEJ2_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS6872</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5093482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HEJ2"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5093482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="168" mass="20306" checksum="60C3E17BF06768FE" modified="2022-05-25" version="1">MTNGTKPAKRLIRKYLKKPMNHYIKRHNDNINSVLVKNKSSKSHRSLNLHIYTTAKAHRLTEAHFVMKYIKKKYWVVKSNHVDDKRHLKYYQDFISINSRGKENHNYKGKLIENYNTQNKIRRCQTYRKNTSMELETLHLKTTKIFKFKNYTVILPTRKRMTLKEIPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HFA2</accession>
    <name>A0A8J2HFA2_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Similar to AK5: Adenylate kinase isoenzyme 5 (Homo sapiens)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HICCMSTLAB_LOCUS6535</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5093032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HFA2"/>
    <dbReference type="OrthoDB" id="6436361at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019205">
        <property type="term" value="F:nucleobase-containing compound kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01428">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000850">
        <property type="entry name" value="Adenylat/UMP-CMP_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033690">
        <property type="entry name" value="Adenylat_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23359">
        <property type="entry name" value="NUCLEOTIDE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00406">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00094">
        <property type="entry name" value="ADENYLTKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00113">
        <property type="entry name" value="ADENYLATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG5093032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="639" mass="71271" checksum="CE4D8A2542CB1AAC" modified="2022-05-25" version="1">MILDQQNGSQVFEDSNAQSVGKWRGEAGLLSTPPNGRFPTQNIGPVKFEPPTVPVIFVLGGPGSGKVTHCDSLIQEKIGITHINMTDLLQQYAIGNDMQDFGLLSSKTVAEVLMLEMKMSPNAKTFLISGYPRNMRDVVEYSEKIQVINGVVLVSWRQEVLERQIDYGAQLGHVILSLARMELKNFYRNVMPVAEYFDRNEILIEVNGERNPSEVYVDFREAIIQILGSPELGFRDRMHQPLEAEVKVERTQPSSANSNHIALLSPTTRINPAKTANKARKGLPSFIWVIGGPGSNKSNLCAQAIRNMPNWSHISIGSLFRTMASSNSTISDSIVAGEMIAQDVVMQLVEQQVLLNRNHDGIVIDGFPRDLNQVQEFESKFGQKPTLVLLDCSKLQLGRGKLDDSVPAFRKRLEIFREITLPMLKTLDSDNRLITIDGDTYVPSVQQEFEATLYQLMRQVRCKEEDNSRDFAISTPIDNNDDNKSNVFETDNINSNHQKTEMPNGRLKNGVNTISNHVINKQKSNHSFKVNNIMNRVNHRGVKKEIGSKIRDAVDESARITNDVLKSSRKNGNHVHLNGAANGASRIFQNGIGHLANGIPPGINRIAPAPSNATISTNNKEPAKKMYSEMNGYHENLHM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2025-06-18" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HFB6</accession>
    <name>A0A8J2HFB6_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Vitellogenin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HICCMSTLAB_LOCUS8746</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5097525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5956066at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005319">
        <property type="term" value="F:lipid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.230.10">
        <property type="entry name" value="Lipovitellin, beta-sheet shell regions, chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.20">
        <property type="entry name" value="Vitellinogen, superhelical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015819">
        <property type="entry name" value="Lipid_transp_b-sht_shell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011030">
        <property type="entry name" value="Lipovitellin_superhlx_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015816">
        <property type="entry name" value="Vitellinogen_b-sht_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050733">
        <property type="entry name" value="Vitellogenin/Apolipophorin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001747">
        <property type="entry name" value="Vitellogenin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23345:SF33">
        <property type="entry name" value="CROSSVEINLESS D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23345">
        <property type="entry name" value="VITELLOGENIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01347">
        <property type="entry name" value="Vitellogenin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00638">
        <property type="entry name" value="LPD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56968">
        <property type="entry name" value="Lipovitellin-phosvitin complex, beta-sheet shell regions"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48431">
        <property type="entry name" value="Lipovitellin-phosvitin complex, superhelical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51211">
        <property type="entry name" value="VITELLOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035245993" description="Vitellogenin domain-containing protein" evidence="3">
        <location>
            <begin position="24"/>
            <end position="1403"/>
        </location>
    </feature>
    <feature type="domain" description="Vitellogenin" evidence="4">
        <location>
            <begin position="30"/>
            <end position="681"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAG5097525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="1403" mass="158850" checksum="0FFF547575BEACA1" modified="2022-05-25" version="1">MARGIKFIAALLVFIITINESIQESIPGLFPKEKTLIYNYYGDVKAGIIEPAAYASQYSISGKLHITHDTSNPKYQHSYLISLQDVKTGLHNGNAAHYEPTKILMPILEAAKVIEEPFIVVYDDFGQVEGVKIPEEEPLWSTNIKMAMASMLQLDLKNMKIDGPIKPHSFIVQEKSIHGDCWTSYDVHAKLPTNDQQDSPIVVTKFASPKNCTNYNVHVFDQMDAERCDVPKVISYKNNSILIEKLIAHGGVNYFPWLGRSEAHYVLNNASFILDKVVTSSEISLPEVDFKDMPLTTDISYQRPQGYYAENAAVDITNGLNVVKQDVIISKLVNMLNEAVDYLEKNHIDAKEPDSVNSQTINRILDIMSFMEISSFEKVFAKIRNVSTDLGTPASNVFIWNLVKNKEVTDGEALSMLAKMAFYVRVPNEDFLIKMEPLLYSSGFLHPEIRKISILSFATMIYKTFKNMPVDQVNDRLDRYLTYFYDGLINEPSYTLKIGYLMAIGNVQVGKIHKLLAPIIRGDISVSENPSHIRLMAIWAISKSVSNDYNAAHDLLWPVMSDYTLPLKLRIAAYDILIRQVPSMENILHIYWFMVYEKSEYLYNYHHTTIKSLANSLDPCDAKLRELTTKIMRFTKIHQPVPHELSASYMIDSIDRIYGHGESFRISLIHDEPTGNLEVIYLEHTIVEDPLNKFFSVTDKNILNILKKAAESIAPVKKMHVDAVLITYGRAVAAVHINEDLIGDFIGLTYPSLLKIWNNNVFGVKYQNIYEQTVISEMGLPVILETKTPTLYSIKLIHESTPQGSLKVGVDAKLWHHQDYAMSIYNPLVNIWHSIRRSSVLNAALPAQFIFGLDFEPKILKLQYPILDAEQLSTLGIMTHTKDITVVTDNEDNILETACPNCTHQVVVSKGDELKNKFEQTLDLQALGLQITAGIFDCENEITPYLINKEWMRALFKERKNSWDSILLHSILGIRQQLKNSVISPPMGSCGKIVKISPSATYPTSHVDMSFKISYENLDMINKIPSLLEEHKLNVLATLDAVSASTNASVESWYLNLGIDIPKGHLKNSLKAQIRRVTSENENLKICIDGQKIYSPIVGDPLKVGLTKEETNGKLIISMDHSDDDQCYRNETLVTITVKGELTNEQKKLFIKDSINSACKQDTAKIIIGFPMNLKTVNVSVITPYRSYDLIEVDLNIENNPPRLNGFGSDYNKNLWGFPLDNTRFDMKFLTLYSLGRKKMCSVYPKVVLTVDGGEIPYLIPLEWILVSGDCIYERFAIFVKNIDDKLALRIYRGDDVIEMIPSDNSTIQIKVNDEIIDPTLNGTYVPKNAQYFWTLKITKLGEHVIATMENEIIVIGYTEGSVSLMIDQTLHRRINGLCGNMDGTYKNKIPKTYRLTQDSMTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HGD5</accession>
    <name>A0A8J2HGD5_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">dihydropyrimidinase</fullName>
            <ecNumber evidence="6">3.5.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HICCMSTLAB_LOCUS7372</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>5,6-dihydrouracil + H2O = 3-(carbamoylamino)propanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16121"/>
            <dbReference type="ChEBI" id="CHEBI:11892"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15901"/>
            <dbReference type="EC" id="3.5.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="PTM">
        <text evidence="7">Carbamylation allows a single lysine to coordinate two divalent metal cations.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the metallo-dependent hydrolases superfamily. Hydantoinase/dihydropyrimidinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.2.2" evidence="6"/>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5094046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HGD5"/>
    <dbReference type="OrthoDB" id="10258955at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004157">
        <property type="term" value="F:dihydropyrimidinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006208">
        <property type="term" value="P:pyrimidine nucleobase catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01314">
        <property type="entry name" value="D-HYD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.140:FF:000076">
        <property type="entry name" value="Dihydropyrimidinase like 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011778">
        <property type="entry name" value="Hydantoinase/dihydroPyrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050378">
        <property type="entry name" value="Metallo-dep_Hydrolases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11647:SF1">
        <property type="entry name" value="COLLAPSIN RESPONSE MEDIATOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11647">
        <property type="entry name" value="HYDRANTOINASE/DIHYDROPYRIMIDINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="Composite domain of metallo-dependent hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="8">
        <location>
            <begin position="66"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-carboxylysine" evidence="7">
        <location>
            <position position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00036696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00039113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR611778-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAG5094046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="665" mass="72617" checksum="C34DC4793BD4995C" modified="2022-05-25" version="1">MSTPVKKVPIHLQSAANRLLIKNGKIVNEDGIVDSDVYIEDGIIKQLGRNLIIPGGTRTIDARGRYVMPGGIDPHTHFELELMGATSVDDFYQGTKAAVAGGTTMIMDFVIPQKDESLLEAYERYRATADEKVCCDYGLHVAVTSWNARTKEEMSILAREHGVNSFKMFMAYKDLFMLRDPELIEAFTACRELGAIAMVHAENGDIIAVNTKKLLNAGVTGPEGHEMSRPEEVEAEATHRACVIASQVGCPLYVVHVMSRSAAEAIEEARKRGVCVWGETLAAALGTDGTNYHHTCWRHAAGHVNCPLYVSAVMSKSSADVIASKRENFVVFGEATAAGVGVDGSEQYGKDMEKGRRFVTNPPLRPDPTTPAYLIEKLAEDGLQCTGSDNCTFNADQKALGKDDFTKIPNGVNGVEDRMSVVWEKGVHAGIMDPMRFVAVTSTNAAKIFNLYPRKGVIAVGSDADIVIWDPNRKRVISADTHVQAVDFNIFEGMEVTGVPEYVIVSGRVCVDETDLKAVHGYGRFVETPLNPPYVYEMVEEREKIPRGIARSAAESKKHADEDLARAKAREAAKVAAAARMQLNNNHTNGNHEAMRNKPKLREISCTPTLPESAVVTPSAKGPRLEGQRNLQDSTFSISEDIDEARRACIRVNNPPGGRSAGGFW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HGG3</accession>
    <name>A0A8J2HGG3_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA-directed RNA polymerase</fullName>
            <ecNumber evidence="2">2.7.7.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HICCMSTLAB_LOCUS7719</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RNA polymerase beta chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="2"/>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5095459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HGG3"/>
    <dbReference type="OrthoDB" id="10248617at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032549">
        <property type="term" value="F:ribonucleoside binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.270.10">
        <property type="entry name" value="DNA-directed RNA polymerase, subunit 2, domain 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1800.10">
        <property type="entry name" value="RNA polymerase alpha subunit dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015712">
        <property type="entry name" value="DNA-dir_RNA_pol_su2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007120">
        <property type="entry name" value="DNA-dir_RNAP_su2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037033">
        <property type="entry name" value="DNA-dir_RNAP_su2_hyb_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007121">
        <property type="entry name" value="RNA_pol_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007641">
        <property type="entry name" value="RNA_pol_Rpb2_7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20856">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE I SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00562">
        <property type="entry name" value="RNA_pol_Rpb2_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04560">
        <property type="entry name" value="RNA_pol_Rpb2_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64484">
        <property type="entry name" value="beta and beta-prime subunits of DNA dependent RNA-polymerase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01166">
        <property type="entry name" value="RNA_POL_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="8">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed RNA polymerase subunit 2 hybrid-binding" evidence="7">
        <location>
            <begin position="90"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAG5095459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="243" mass="27969" checksum="104E95DF7246A324" modified="2022-05-25" version="1">MERDALIAHGTSYLLRDRLFHCSDKSTATVCRKCGSLLEPVTEHIRNFGERRSRCKFCNDDKELYDIDVPYIFKYFWDSKWDHLEQKFKVGYWRSKEDAIVDNVRMCQVLSIKDVMRACITFRVTRNPAVGDKFTTRAGNKGVCSFMFPPEDLPFSESGMIPDIMFNPHGIPNRMTIALLIEILAGKSAASHGLVHDATPFRFNEKDTAIDYFGRLLELAGFDYYGEEVMYSGTEGTMFEVYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HGQ8</accession>
    <name>A0A8J2HGQ8_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to HMCN2: Hemicentin-2 (Homo sapiens)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS7329</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5094003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HGQ8"/>
    <dbReference type="OrthoDB" id="10031887at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032589">
        <property type="term" value="C:neuron projection membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050808">
        <property type="term" value="P:synapse organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00099">
        <property type="entry name" value="IgV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000533">
        <property type="entry name" value="Uncharacterized protein, isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:001061">
        <property type="entry name" value="Uncharacterized protein, isoform C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013106">
        <property type="entry name" value="Ig_V-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037448">
        <property type="entry name" value="Zig-8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23279:SF45">
        <property type="entry name" value="DEFECTIVE PROBOSCIS EXTENSION RESPONSE 12, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23279">
        <property type="entry name" value="DEFECTIVE PROBOSCIS EXTENSION RESPONSE DPR -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07686">
        <property type="entry name" value="V-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035285575" evidence="1">
        <location>
            <begin position="21"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="2">
        <location>
            <begin position="15"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="2">
        <location>
            <begin position="137"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5094003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="269" mass="30295" checksum="C650A30F102F896C" modified="2022-05-25" version="1">MRDRLSWYMVFLILPTILLARSLDKVNEANDNNTVSNVTVQLGGTAFLHCKVRNIGERSISDAEISWIRRRDWHVLTSSLFTYTNDERFQALHPEGSDDWTLQIKYVQERDNGTYECQVSRSTGIISHFVNLNVVIPEAFILGSEEHHVDVGSIISLVCIIEKSPTPPQYVFWYHNNRMINYDTARGSVSVQTEPGPTQSRLTIQQAVETDSGNYTCRASNTKPASIFVFVTEGDKMAAILRRKTSSGGERTLGELILALIIASTLLVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HGR2</accession>
    <name>A0A8J2HGR2_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NudC domain-containing protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HICCMSTLAB_LOCUS7899</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5095820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HGR2"/>
    <dbReference type="OrthoDB" id="428655at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd06467">
        <property type="entry name" value="p23_NUDC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007052">
        <property type="entry name" value="CS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037895">
        <property type="entry name" value="NUDCD1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21664">
        <property type="entry name" value="CHRONIC MYELOGENOUS LEUKEMIA TUMOR ANTIGEN 66"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21664:SF1">
        <property type="entry name" value="NUDC DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04969">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51203">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CS" evidence="6">
        <location>
            <begin position="255"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAG5095820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="485" mass="55527" checksum="C3156FCB5A156B77" modified="2022-05-25" version="1">MTKIVDLRPKKELLNNEFEKYQFSSEIIPITEEIELCKHIKHKEPSSNQDSWLEAKLFAFHNHLFENPYDSSCWFWDQDYGVWQLKEDGSLNQVETKKVLCDLPYKFNPTIAFAGDGVVILSRGDTVLEVVLINKLSSSLMIEGTEPGILLDARYVEPKNLLIISTYTIVTTNGKKQSKLILLFYKLKNPGHWHEGLEFHKKQELVINGPIEYVFIEPNGEYINLLSQDLAKFIHDSLNGIQEKDCSEGSKIADIKIPKYSWSQDEKSLTVWIKIPQKHKGSKPNVEVSATYISVVIEDEVLINGEVPFGLDHKSATWNCENDTLKLKLMKQETGQMWNELIKNDTNGECLPNDLLASEIHSRLAHLCSEQQGNDSDQQAIGFNTEQLEECDLEGGENMLQRINLTNHTTTHLTVLTSHNRILFTHKLKTCQVLCARYNHDGCVWEPVHRDEEWELVHKNIFPGFGYVEASKANKKFCISPANVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HH09</accession>
    <name>A0A8J2HH09_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS5461</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5090020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HH09"/>
    <dbReference type="OrthoDB" id="7697573at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5090020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="143" mass="16146" checksum="595F788534F40748" modified="2022-05-25" version="1">MALLISKGTVEVTIRYAESTAYNEEYVTEPDIYTYDDDKIFLNYTGYYAVISATMGEYIIDSGISIQIPFCEILDFGAGAFVSLLGFTDDNCPPKPGVYGNEAYLFPTEEFGDDFPSNQYKVVVEFINENEYIMALSIFFDIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HH59</accession>
    <name>A0A8J2HH59_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Similar to RpL3: 60S ribosomal protein L3 (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HICCMSTLAB_LOCUS10188</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="4">The L3 protein is a component of the large subunit of cytoplasmic ribosomes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the universal ribosomal protein uL3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5101115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HH59"/>
    <dbReference type="OrthoDB" id="1611972at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000079">
        <property type="entry name" value="60S ribosomal protein L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1430.10:FF:000001">
        <property type="entry name" value="60S ribosomal protein L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.960.10:FF:000001">
        <property type="entry name" value="60S ribosomal protein L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.960.10:FF:000002">
        <property type="entry name" value="60S ribosomal protein L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000351">
        <property type="entry name" value="Ribosomal protein L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1430.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.960.10">
        <property type="entry name" value="Ribosomal protein L3, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045077">
        <property type="entry name" value="L3_arc_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044892">
        <property type="entry name" value="Ribosomal_L3_dom_3_arc_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000597">
        <property type="entry name" value="Ribosomal_uL3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019926">
        <property type="entry name" value="Ribosomal_uL3_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11363">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11363:SF5">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00297">
        <property type="entry name" value="Ribosomal_L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00474">
        <property type="entry name" value="RIBOSOMAL_L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="18"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00056881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAG5101115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="415" mass="47126" checksum="CB8CDCC3F093AE99" modified="2022-05-25" version="1">MSHRKFSAPRHGSMGFYPKKRSQRHRGKVKAFPKDDPSKPVHLTAFIGYKAGMTHVVREADRPGSKVNKKEIVEAVTILETPPMMIVGVVGYIETPHGLRALTTVWAEHLSEDCRRRFYKNWYKSKKKAFTKASKKWTDDLGRKSIEKDFSKMIKYCKVIRVIAHTQMKLLRQRQKKANIMEIQLNGGTIEQKVQWAREHFEKPVAITNVFAPDEMIDCIGVTKGKGYKGVTSRWHTKKLPRKTHKGLRKVACIGAWHPSRVSFTVARAGQKGYHHRTEMNKKIYRIGQGIHTKDGKIVKNNASTEYDLTEKSITPMGGFPHYGEVNNDFVMIKGCCMGPKKRIITLRKSLLVHTKRAALEKINLKFIDTSSKFGHGRFQTAADKASFMGLLKKDRIREEQAQTAAAAPSTAAAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HHP6</accession>
    <name>A0A8J2HHP6_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS7950</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5095922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HHP6"/>
    <dbReference type="OrthoDB" id="8186197at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="472"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="521"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="554"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="207"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="236"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="274"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="299"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="334"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5095922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="596" mass="66122" checksum="94A9447719AA7844" modified="2022-05-25" version="1">MSQSIPGYCYTNPSFCRQSEQIPDDQNDELPPPPQFQEVEDLPPPPPPAPTTVTTSVHFQHPQNYGQGHANPGFPIRSDPDAIELDRYAKTTDRYCYLDENPKKDIVQERRIIYDRNTRSRYEYIDDDDHPPQPRLQRRASLSRFEMMNQRQNYQFVRQGSYHGQQLQGLEDRNGNQRARRFRQDGSDRYALVPADEGAIDVESSSWINAGHSSPRGRYARVPMQEDEPPVLPDRNNYNNQPELRVNNNGFSSRNNLATQKLHEILTTPRKPRSKSEDRNLSPGKIDRGTPHRGAQFTPPISATTSPTGRGVVPGSSRRETPIGTPQRALSPLRTPQTSTPNKETPSARRCLPLNEQQDICPASNCGRTRYYQRRDATSPTELSQFSEPPPRYAFLESNSESMPMVIGSPKYQVLSSRSESQSQLKRNAYQSVESAFIARTAVVPPLSPPSSDANTTLASGIEKNERKSAPLILVLVGILTCGLALYLSWTQGRQYYLDSAAGCGVCCALAGACRSLRRPWTGLGLAGLSALSCAGLLLLAAKSPRKGTPLHDVTAGALCGVSLLGAALALLALLAPKCNLGRHRRVHSWMPRFSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HHU3</accession>
    <name>A0A8J2HHU3_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Carboxylesterase clade L member 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HICCMSTLAB_LOCUS7991</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5096001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HHU3"/>
    <dbReference type="OrthoDB" id="3200163at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019819">
        <property type="entry name" value="Carboxylesterase_B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051093">
        <property type="entry name" value="Neuroligin/BSAL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43903">
        <property type="entry name" value="NEUROLIGIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00941">
        <property type="entry name" value="CARBOXYLESTERASE_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="604"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="783"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="6">
        <location>
            <begin position="77"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="56"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="935"/>
            <end position="995"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="21"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="59"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="957"/>
            <end position="966"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAG5096001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="995" mass="110299" checksum="B4749BC33296A643" modified="2022-05-25" version="1">MRTRPSCTTLGNLGRKKKRGHGEAVPHQKERPRNATLLIVAIGLLWTMRACDALTAPGSSSQPQPQQQQQQQLKYSSRQVRTRYGTLRGIVARSMSVEGVEAYLGVPYATPPLGALRYMPPVTPTQWRGTKLADTLPPACPQKIPGLEPNLPRRRRAYIDNIIPLLTNQSEDCLYLNLYVPRPQHGSSTELLPTLLLIHGDSYSWGAGNPLDGTALAAHGRIIVVSINFRLGVLGFLKTGTKSSAQGNYGLMDLVAGLHWLRENIEAFGGDPERLSILGLGTGAALANFLAVSPMAKELVERVILLGGSALSPWAIQRDPITIKRRVAEQTGCLGDVETDDIAICLRLRSIDELLNVNLDTPRFTSGFAPFMDGTVLPLGSQVTQPTASSAGILPLVPGPGSEFTALGNRDLLMGLTSCEAWLDLSEDDLKVGLNFFFFLLKLMNYFIKIVCKKLNKILFQNGINATRRDRILRTYVRNTYRYHLHEIYSTLKNEYTDWEKDEQSPNAIRESLLSLLGDGQVAAPLLRLALLHSASGGRGYLFHFQPGDHPSQRGDELPFLLGIPLLRNEPSRWLYSVNYTIEDESISRMLVRYIANFVRRGKYPFLHPFIYFYFYFYFYFYRDPNEGNPNNEKFMKNSPFWDSYDSINQLYLEVSKLTEMHSHYRGHKMSLWLNLLPQLHRPGYEISMRHHHLAESPSLYEGAVRPQTMALPLPPPPLSVPMPTEASISSKPIESTECTPNISVVPMSTIIPTRSTQQPLPKLSPGPNNLLRKFASNHYQSYTTALTVTIAVGIFLLLLNILIFAGIYHQRDRNAAAAAAASINPSLSLGFVEHKKKERLLEAGCSGVESISASGKLSRLSSFVLNDSSISSSPSIHKHKLAQELELQLQEFQCSPPPGGGKRMSLDPPSYAICKSPGVNRSRTPSPCVDVAAQNNQLEPHDRGIADDDDDDEFLPDPPPPPKVPAPNVCSGILRQPGTPGSAKKRVQIQEISV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HIH3</accession>
    <name>A0A8J2HIH3_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Similar to slc38a10: Putative sodium-coupled neutral amino acid transporter 10 (Xenopus laevis)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HICCMSTLAB_LOCUS8958</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5097949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HIH3"/>
    <dbReference type="OrthoDB" id="513400at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF646">
        <property type="entry name" value="SODIUM-COUPLED NEUTRAL AMINO ACID TRANSPORTER 10-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="30"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="78"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="118"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="143"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="183"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="225"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="268"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="310"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="335"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="369"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="9">
        <location>
            <begin position="5"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="544"/>
            <end position="571"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAG5097949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="820" mass="92295" checksum="138404505B246DAC" modified="2022-05-25" version="1">MAYITHVMTLANSIIGVSVLAMPFCFKQCGIILAILILLFCSLLSRLACHFLIKSAVMSRRRNYEFLAFHAFGPMGKFLVELFIIGFLLGTCIAFFVVTGDLGPQIIGKILNKNPEDIRLSFLLTTGLIIVLPLGLLKNIDSLSSICTVTIGFYLCLVIKVISEAMTHIFDGDWVDDVNYWRPAGILQCLPIFSMALFCQTQLFEIYESIPNVSLEKMNKVVKGAINICTIVYLFVGFFGYVAFCNQSFSGNILTSFEPSLTSDCIKIGFVFSVLFSFPLVIFPCRASLNSLLFRRNYAHESSTNYIPEIRFRCLTSMIVLVSLITGLLMPNIEFVLGLVGSTIGVIICLIFPAGFFIAISTKNTNERLLAQVILFIGMWIMILGSYANLYAIDESSTTKVSIVTDKPFVPINNIHLNVDDNNNIEIPHKLEKKISQKLPPNLTSIADNKIPEEKPKNEELIKLPKVLTAEEKLKEVLAAEEKNTIIENKEKVEPEPENSINVDAIKKEESEIAEADVKDPSLQEQQRVKETLKQHKIESIELMKEQKAILKNIEIKKVEMEEDKKFLESQAKSMDKINKIDKMDNKLNEGEKSDVHIRSENKTQGINLNILNNLNKSLSFNSSEKINQSKINTIVPLDPKINVPSNESRGPVLNALTNWTVNQIINASGFVNSEDNHSVNENNNNINLKSVNEVPIPLPLKLNMSAENNNNNINSNEDKVGRDILQNRGREKRDVEELDKIILDEAVKSTNEEECTSKPKEDKILSTESIIKTNINLSDQEFQDKVNSVDLALDPLTNSEYRVFKKRDLKAFKPGRRRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HIH6</accession>
    <name>A0A8J2HIH6_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Similar to FAM135A: Protein FAM135A (Pongo abelii)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HICCMSTLAB_LOCUS11003</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAM135 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5102414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HIH6"/>
    <dbReference type="OrthoDB" id="273452at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000004">
        <property type="entry name" value="Protein FAM135A isoform a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007751">
        <property type="entry name" value="DUF676_lipase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044294">
        <property type="entry name" value="Lipase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12482:SF5">
        <property type="entry name" value="DUF676 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12482">
        <property type="entry name" value="LIPASE ROG1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05057">
        <property type="entry name" value="DUF676"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF676" evidence="3">
        <location>
            <begin position="173"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="73"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="18"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="33"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="81"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG5102414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="443" mass="50197" checksum="2CB34EAAA5D3AEF7" modified="2022-05-25" version="1">MNMNKTPVAKDKKSKTKSGKEKIPEHSYEEVRLPPPKMFQDEPPPPEAFRDPAPAPAPVPMVDNPLYHVYETVKRARSPKQNKTAPCSPQRSRDRVERERESVYARDFCLDCYQEGKELLQSTQDDVINFKKCKEEFKRQMSFSGKMYSDYTGVASSLPYFNISDEYRIFSPEGPHLIICVHGLEGNAADLRLVKTYLELGLPGAHLDFLMSERNQGDTFSDFDTMTDRLVEEILHHIDTSGLNPTKVSFIGHSLGTIIIRSALTRPQLRPLLPRLHTFLSLSGPHLGTLYNTSGLVNAGMWFMQKWKKSGSLLQLAMKDASDVRRSFMFRLSQKSNLQRFKHVLLCGSAQDRYVPLHSARIELCKAAVRDPTDQGTAYREMVHNILYPIMSASGVSLVRYDVHHALPPTANALIGRAAHIAVLDSELFIEKFLLVAGLKYFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HJX6</accession>
    <name>A0A8J2HJX6_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Similar to alkbh6: Alpha-ketoglutarate-dependent dioxygenase alkB homolog 6 (Danio rerio)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HICCMSTLAB_LOCUS9900</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the alkB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5100827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HJX6"/>
    <dbReference type="OrthoDB" id="412814at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.1520">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032862">
        <property type="entry name" value="ALKBH6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46030">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT DIOXYGENASE ALKB HOMOLOG 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46030:SF1">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT DIOXYGENASE ALKB HOMOLOG 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAG5100827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="250" mass="29115" checksum="14CE9AEF8760E802" modified="2022-05-25" version="1">MIHGAYDAVLQCNDKKNNSNICYKMASGIICASFGEVEKLLDLKVVFRNLGLQKQVLLSASYVPNFIDDNEEEELMRHVSSCPLPKQTQLSKRRLQNWDGIPHQKGKITEEIPKIFRFKYLLLQLKSHTLLEVTERLDTEEDPRQLKPEFSFLLQQRSLLVLQHTLDHDYLHSISGYNCDTIDSNYIRNLNLCSYICEESEKLNHKTRISLTIRHVPKISKLKLQFEFSTFFNIKLTIFSIDVILTKPIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HKN9</accession>
    <name>A0A8J2HKN9_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Nuclear transcription factor Y subunit gamma</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">CAAT box DNA-binding protein subunit C</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Nuclear transcription factor Y subunit C</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">HICCMSTLAB_LOCUS9402</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5'-CCAAT-3' box motif found in the promoters of its target genes. NF-Y can function as both an activator and a repressor, depending on its interacting cofactors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Heterotrimeric transcription factor composed of three components, NF-YA, NF-YB and NF-YC. NF-YB and NF-YC must interact and dimerize for NF-YA association and DNA binding.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the NFYC/HAP5 subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5100136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HKN9"/>
    <dbReference type="OrthoDB" id="10259368at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005814">
        <property type="term" value="C:centriole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030992">
        <property type="term" value="C:intraciliary transport particle B"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042073">
        <property type="term" value="P:intraciliary transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22908">
        <property type="entry name" value="HFD_NFYC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd23683">
        <property type="entry name" value="IFT52_CTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000006">
        <property type="entry name" value="Nuclear transcription factor Y subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2800">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039975">
        <property type="entry name" value="IFT52"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055460">
        <property type="entry name" value="IFT52_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055458">
        <property type="entry name" value="IFT52_GIFT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12969:SF7">
        <property type="entry name" value="INTRAFLAGELLAR TRANSPORT PROTEIN 52 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12969">
        <property type="entry name" value="NGD5/OSM-6/IFT52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23352">
        <property type="entry name" value="IFT52_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23355">
        <property type="entry name" value="IFT52_GIFT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="IFT52 GIFT" evidence="14">
        <location>
            <begin position="2"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="IFT52 central" evidence="13">
        <location>
            <begin position="187"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="12">
        <location>
            <begin position="313"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00040590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00042333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00042663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF23352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF23355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CAG5100136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="553" mass="62564" checksum="DC1CF641871F00C9" modified="2022-05-25" version="1">MDSIRGFINNGKNVLVMLGEGGENKFNTNINFLLEEFGIMVNNDSVIRINYSRTLHPKECTISQGLSNKSRFVKNRDEVVNMNFIYPYGATLNVVQPSVVALSSGTMAIPTNRPICAYYSSPTSSGKLVVLGSSRLLTDSYIEKEHNDALREMIFDFFKSKEQFSKEYHFDDIDYSEYNFVPDITQLADEPKVCTQDLDTIDIPREYTKLFKHHFYSINLSMIPECISAYQLLGVFPPSFQELQPPALELFDLDEEFSSDLLKLSQLTNKYMSMKDPANESELDYYIREFGEMIRINTSSDIPTSKEILNFNDLKTQSLPLARIKKIMKLDGDVKMISAEAPMLFSKAAEIFIHELTLRAWIHTEDNKRRTLQRNDIAMAITKYDQFDFLIDIVPRDELKQSKAQDNVVRTSMSSDQVHYYFQLAQQQSNNQTVQNNGAQSIQIVQPPAGQIQTINMPISNSVEQAPQQSNQQVIQLQQAQSPSSQSGGIQIVQQIIQLTPQQLQMIRMQVQGGSNQPIIIQAAPIAAQPQIIQVAGSGQAPVYLQTNGTDNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HKW2</accession>
    <name>A0A8J2HKW2_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS12330</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5106579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HKW2"/>
    <dbReference type="OrthoDB" id="5915502at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38640">
        <property type="entry name" value="GEO09659P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38640:SF1">
        <property type="entry name" value="GEO09659P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="124"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5106579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="153" mass="16200" checksum="9938B5A063177FE2" modified="2022-05-25" version="1">MASSGNSADSLLTKLGLQPVTRCSMAKLYVPALGVAGYSGLGYSVLNPDLVLRFSQNVDITNMFLGTSLVGMGSYIYTREHMKPARPVVRVMYSVTGALLLNFGSVLIWAVVKSVFGMNKVTQCTLAGTATGAALIIGGHSYLNFVDSQVAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HLC5</accession>
    <name>A0A8J2HLC5_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS10567</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5101665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HLC5"/>
    <dbReference type="OrthoDB" id="7690819at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035234368" evidence="2">
        <location>
            <begin position="18"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="182"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="188"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5101665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="224" mass="24492" checksum="51AD716221CA3C38" modified="2022-05-25" version="1">MIAIAIICLAIIASTSSQPVSPKSRYNGPAASLFDSPEFKRYLTSNGLKPLDNFNPAENPTQEKPNPSQILDSLQKRFNASRDELYQSVDSYLVGILREFKEYVINFLGNTSSYVEQNQYDLGNATLRAVDQALQAKYASFVSNLMLATDNAVEDYNTKTATITQKLERKLAELNGRAEVALGGGNNGVSQKPTNNGPDVLTDLNGNKINLLGEGESKLRLPDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HLW7</accession>
    <name>A0A8J2HLW7_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS10548</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5101646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HLW7"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035196934" evidence="1">
        <location>
            <begin position="20"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5101646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="86" mass="9517" checksum="F89440E8959F3C1D" modified="2022-05-25" version="1">MTKLLVFLLLVTFAVAVLSARDDDGSYQEGGTYQQQGDSHQAKCARLLVGDRRDPAPEDANNCLHECVIYKKYVGGYRENGACRCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HM15</accession>
    <name>A0A8J2HM15_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Similar to Cml6: Probable N-acetyltransferase CML6 (Rattus norvegicus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HICCMSTLAB_LOCUS11614</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5103647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HM15"/>
    <dbReference type="OrthoDB" id="41532at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050769">
        <property type="entry name" value="NAT_camello-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13947">
        <property type="entry name" value="GNAT FAMILY N-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13947:SF37">
        <property type="entry name" value="LD18367P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="44"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="N-acetyltransferase" evidence="3">
        <location>
            <begin position="106"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG5103647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="277" mass="31686" checksum="0C533D21D73AA971" modified="2022-05-25" version="1">MSHIIVIREYKPGDELNCHGMMTNSIMSSLNSTFLANVLKELTFQLMILSAAIMFIFFGLSLTICLSVIPITIIGTYIGTYLGFLMMTAEINQELSNISSNKLYMSNLFSCFWVAEAFQPYSMIRNPADVNYTVMTEKEFRDSNIDVSSQLKKIVGTIGLLKSYKSDKGAWIKRLCVAKNYRRKGVGSCLLNTAVQFAVDQGYSSVDLVFSEYSDGCRELCFKKGFELKQMYHKSIIGPVVNVLQYELTYKIKPHDDYIDSYYNNYQNYNHPKQHFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HM24</accession>
    <name>A0A8J2HM24_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS10312</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5101239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HM24"/>
    <dbReference type="OrthoDB" id="7697573at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5101239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="134" mass="15049" checksum="DBC6B9B73750D9E7" modified="2022-05-25" version="1" fragment="single">GAVEIIIEDVLCPTFSEEYITEPDVYIDVNNQIFTHFQILGASMGEYVVQTGLEVQMKLCEILDEPIIMGPILHLLGFVETDCPPSPGVYGNQGCSIPMELMPDHFMPNKYLVIGEVLFEEEKLVVVHIYCNVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HM72</accession>
    <name>A0A8J2HM72_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Similar to EFCAB1: EF-hand calcium-binding domain-containing protein 1 (Bos taurus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HICCMSTLAB_LOCUS10683</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5101782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HM72"/>
    <dbReference type="OrthoDB" id="191686at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028846">
        <property type="entry name" value="Recoverin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23055:SF60">
        <property type="entry name" value="CALAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23055">
        <property type="entry name" value="CALCIUM BINDING PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035302954" evidence="5">
        <location>
            <begin position="19"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="6">
        <location>
            <begin position="527"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="6">
        <location>
            <begin position="572"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="109"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="201"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAG5101782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="630" mass="69970" checksum="7FB2C82AB84454F9" modified="2022-05-25" version="1">MTWWITGLLIASIVCIEARELVRPGARLIKNHQHGRLLLMRDRRNPIASYNPSRAMMLTGFYRPIRYSTGSQATGVFAQGNAVSGGYLAGTHSRNYLPRAPEPVAQPHVLSAEAEAEAAREPEPEQQGTPVYGNQEDVGYPASQSDQELGSEPETQLKDENEGLPETPFQEEEQEDEKVSKPVSVNPQGNKTKKTTVNVATDEEEDEEEDDDDTFKPYLPSKSNKGVPNLTNFFPMMFSFPRSAGKSGSSSGSGMITAIANSGYVRVVRAALPDPDPRHHGHYSQYRPQSYGGDYYSGYDNYDNYGHGGYNQGYGGYGNNYNPYQNNGYSSNSAANAASFSSPWGSGAFANANSASGDVGALFSRLPISARAGALVMKSVSIFLSSGRKPSVNSKKPGEQIQRRRRRKLTEEAAMKAYHAKVVEALKKKTRFSRPELEALCKIYRKITTVPTAKIGVTLFTKGAPQTIQTVEGIDRTIFRELLHNTFDIITEDALIERMFCCWDRDSEGAIRLESWIMGLDVFVRGTLRDKMEFCFRVYDLNSDGFITKDEMFQLLKNCLIKQPGEEDPDEGVRDLSELILKKLDVDHDGKVSFNDYECVVKEEPLLLEAFGQCLPTEESCSAFLTTLQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HMC5</accession>
    <name>A0A8J2HMC5_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similar to LRRC74A: Leucine-rich repeat-containing protein 74A (Homo sapiens)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS12500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5106918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HMC5"/>
    <dbReference type="OrthoDB" id="8436363at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052394">
        <property type="entry name" value="LRR-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24114:SF2">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24114">
        <property type="entry name" value="LEUCINE RICH REPEAT FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00368">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5106918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="559" mass="63280" checksum="D2425E7F359889FE" modified="2022-05-25" version="1">MVYIKEHKSLDREDDDDQHEHPHDEAEDSSSYSSNPRPHSLLEYLLEETLSQVFSSANFQDTDQPSEIKSESNESLKTVITPQDSEFSDELQSENGSSINIPEDAGLRPGSWILFPQLPGDRDEGVIKFIELTKELNIPPLGQIPQMLNTNQIDLKSYGLDPRTMKIICEALNSNTTVKILNFQDNWLTADACYHLNDLLINNNIITEINLSGCRIGEAGSKELETGISSAESLQYLNVSRCDLGDEGLLYLSKGVYCSPSLKKVNFSNNNLSENCASTLQKMLIQTDNLDELNLSWNNLNSSKFWETFIIGLTANETLKYLIVNWNGLDGECVPYLTEYLSSDPNLLRLDLRDNSFTSVEKIAEALINNTKLEIVELGNNPVQAKEVFIFIQTLTRLTSTSRLKMIDLENIWADKEVLPLLDDLKTRLGLDVTLGGILSNYEIIGPDPRKIFLKRANFEAMKPKKKKLKRNFGQFVMSLQDLIISREAFKKSIKSAKIKLSESLITEISKAFEIGDDAIDLSILKQFYLKEYPEATELPPLIVPRKKRKIKKKSKKIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HMS1</accession>
    <name>A0A8J2HMS1_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to DNA-binding protein P3A2 (Strongylocentrotus purpuratus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS11564</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5103547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HMS1"/>
    <dbReference type="OrthoDB" id="6288734at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019525">
        <property type="entry name" value="Nrf1_NLS/DNA-bd_dimer"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10491">
        <property type="entry name" value="Nrf1_DNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nuclear respiratory factor 1 NLS/DNA-binding dimerisation" evidence="2">
        <location>
            <begin position="52"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="14"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="207"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="533"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="22"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="208"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="218"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5103547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="654" mass="74850" checksum="9B990BAE4E90CCFD" modified="2022-05-25" version="1">MRYSAVQEDGYGVGLRQDIQPNNNNNNNNISNNNVDDSMMAATGEVEPVGESTADECSMVYNLPLLFANGYPTSLEKITLPQLEKFITFMTRCSLGNNTTQVLNKPAWWPTEVEFSIPLVRPKKSGDSWMRCLRRVVLQCYSFHQSEYLLRFCTYLAQYPQAKLYYVNNWDSTTSLYHKSTGKLLATFRNENMDYDKVIEPHRKSLLPINNANSNSQAKHKKTQQRNHRQSPSSLVRIQPQMEEIYLCDNCDAEFLDLKQMKDHEKSCGETVKTVHQETSTCWRPMTPEVEAEPDLTQNQFMEYFHLSTPNQQPPKTTTDPSSIPAISIETEPSRSSRRMKPSANLCRSSTIPFSSPAGLALVKKSKGMNEATKRDRVDRIEWHLSAPALTKTNRPKWFGKFSSSGRWVVTYKPNTSKENPQTDDYVHQYTFGAVRRKPSLDVRSQILYIACGSPFVKLNRLTDEQLQDLKEHPWKYQPPIRKIRHRIRPRLIMRISGKSTGQKRQYSSRLTEVMPIIEQGPEINQIKKGSLKRGYTPNFRSRPSMVPISRIPSSTPTIEEPLNKTIVIVDLCSSDEEEIPSNCVILSDENRDPLNSTFENVRMSNSFSKNLGLQPMNDRLRDSILTDDNDKSCNKRLTNGVIDAFSPILKPTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HMW6</accession>
    <name>A0A8J2HMW6_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS11249</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5102918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HMW6"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5102918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="63" mass="6889" checksum="8A7E95FD78FE5CED" modified="2022-05-25" version="1">MSGTGTLLINPGCTLGNERFIIKSTKKDAKPTDNFPFPMFNISQLASNLSEKPERPHALTKIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HMX4</accession>
    <name>A0A8J2HMX4_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS10598</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5101696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HMX4"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="353"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5101696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="516" mass="57681" checksum="FCD41CF9454D4F9A" modified="2022-05-25" version="1">MSKKQVMTSWRFRWRSRKGIAPGLTGNFAGHRTDDLAGDHAEGLSGSLAGDHADGLSGGPADFLARDRADGNTRGLTGGCFAGVLLKITLTIFLEVSLEITLTISLEVLLVITLTVSLVITLTVFLEISLEITLTFFFRGLAGDHADEKELEEEGGQTIVQLARQSVLSSEQRASTFRPLIGAILGVLYTSPGNTHAGIQFSCSKRPGQKETATATIFLRYFFSRHALFSSQMISEIFRCFSKTTIIDQKVRKKNENLIKDRRKFPRFLEPKLTGHVVDNCNEEIAKARSNIDRLISSDSKRYTCPGHLMTRQNQRRLLCPGILNNTHVSCPRISSTVESTSRPTHFQYPSSYYSIILGAFYFSVLLLFMIELSVVYFEKYFFGNYKERNFVEKLPQKSVIQDSVTNSKNSADSVKIVDVEKSLMGILFIHFSLSHLPYYKTPGILPILDLIFCSCSNHIRKKISSVDDKETQCVANRSIKLLGGRRLPKLAGAHLDAKSENDKVIAEPGNRRRHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HNL7</accession>
    <name>A0A8J2HNL7_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Similar to Flna: Filamin-A (Mus musculus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HICCMSTLAB_LOCUS11127</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the filamin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5102674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HNL7"/>
    <dbReference type="OrthoDB" id="18740at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:001145">
        <property type="entry name" value="Jitterbug, isoform I"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044801">
        <property type="entry name" value="Filamin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017868">
        <property type="entry name" value="Filamin/ABP280_repeat-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001298">
        <property type="entry name" value="Filamin/ABP280_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38537:SF16">
        <property type="entry name" value="CALPONIN-HOMOLOGY (CH) DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38537">
        <property type="entry name" value="JITTERBUG, ISOFORM N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00630">
        <property type="entry name" value="Filamin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00557">
        <property type="entry name" value="IG_FLMN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50194">
        <property type="entry name" value="FILAMIN_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="Filamin" evidence="3">
        <location>
            <begin position="20"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="repeat" description="Filamin" evidence="3">
        <location>
            <begin position="114"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG5102674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="244" mass="26573" checksum="82E4A4887CA5E404" modified="2022-05-25" version="1">MTVSWNGRQLKGCPLQISVTSAADASRVICSGDGLKNGIVGQEIRSFIDTRRAGPGELTAHCVGPHKVAYCELYDHGDATFTLNVKPQEAGRHALTIKYAGEHVPGSPFTLRVSGAPDASKVRVYGPGIEHGVLATFQSRFICDTRGAGAGQLTVRVRGPKGAFRVEMQRETQKDRIILCRYDPTEPGDYRVEVRWAGVLVPGSPFPVRIVDTQDELLLYTQGADNYSRGHHTISSWRGSQAIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HNR5</accession>
    <name>A0A8J2HNR5_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Similar to Transposon TX1 uncharacterized 82 kDa protein (Xenopus laevis)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HICCMSTLAB_LOCUS11235</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5102890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HNR5"/>
    <dbReference type="OrthoDB" id="7701518at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="115"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="140"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="200"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="150"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="162"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="209"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="229"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG5102890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="358" mass="41305" checksum="7F5C01A6173FC4F3" modified="2022-05-25" version="1">MCSSRDVTGRHEEGKISYEPQNLSIDRHFDLSPGVNYHASSDVIEQEFTKLGIKLSSEITFLKVGIQNPPFNHILSFRRQVYITPQDEEKFPETIKIIFEETTYFIYLSTDSISCFICKKEGHLAKNCPTENLTMHQQTEPLQTQAQETEEIKKDSKKELMTKTTESNKPLLSQTQNPIDNLNTQMTSQEFQIPITPLLTEMKRPRSLPSKTSNCTSTQRLKLPRGDDSSTDYDSSDNDIPEKSQNKTKPKKIKAQDKILAEDWVNITRIIAQKKDYPLTALQLNDFYTKLHCNKYPIELTLQYTTDLLGLKKMMNDVYPYLSSSLKNRTTRITNIFEEHLVAEEQNKARSMDTDLTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HPE6</accession>
    <name>A0A8J2HPE6_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Similar to aop: Ets DNA-binding protein pokkuri (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HICCMSTLAB_LOCUS12937</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the ETS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5107825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HPE6"/>
    <dbReference type="OrthoDB" id="6408625at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08535">
        <property type="entry name" value="SAM_PNT-Tel_Yan"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000516">
        <property type="entry name" value="ets DNA-binding protein pokkuri"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.50:FF:000061">
        <property type="entry name" value="Ets DNA-binding protein pokkuri"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000418">
        <property type="entry name" value="Ets_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046328">
        <property type="entry name" value="ETS_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003118">
        <property type="entry name" value="Pointed_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11849">
        <property type="entry name" value="ETS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11849:SF201">
        <property type="entry name" value="ETS DNA-BINDING PROTEIN POKKURI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00178">
        <property type="entry name" value="Ets"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02198">
        <property type="entry name" value="SAM_PNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00454">
        <property type="entry name" value="ETSDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00413">
        <property type="entry name" value="ETS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00251">
        <property type="entry name" value="SAM_PNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00345">
        <property type="entry name" value="ETS_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00346">
        <property type="entry name" value="ETS_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50061">
        <property type="entry name" value="ETS_DOMAIN_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51433">
        <property type="entry name" value="PNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PNT" evidence="6">
        <location>
            <begin position="56"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="ETS" evidence="5">
        <location>
            <begin position="292"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="151"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="219"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="396"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="229"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="421"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAG5107825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="462" mass="51733" checksum="6428C85F39ACB2E5" modified="2022-05-25" version="1">MKLLPTIQLPQLPPVSAAGGMTGMDSRLPPGISLPFSPTDLLWRYPTMSFSSHPPQSPLLDFKTHLPSSLASDPRVWSRDDVATFLRWAEREFDLPQFDMDMFQMNGKALCLLTKSDLGERCPGAGDVLHNVLGMLARDFNQLQRCLPSSPVTPTRHSAYPLSPHSHPPTPTWAENHYAAANLASLMSANSVTLSPAPSVDSQAGSPGHTESNQIQVYRSDSDEDNHQSSSSPPATPTALTAQRLSEVCVKDQPSPTLPPQLMPLTPGGFRPASTAREFFPSDSPEPNTNGRLLWDFLQQLLNDPSQRYTHYIAWKSQETGVFKIVDPPGLARLWGIQKNHLSMNYDKMSRALRYYYRVNILRKVQGERHCYQFLRNPTELKNIKNISLLRQQMRIKSEPEEESPTSINGIEPEVDMPTDLSMSSMNQPSCEQPLPLLDPPAKYRSHAYNLAKTNQEPEERK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HQE9</accession>
    <name>A0A8J2HQE9_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Large ribosomal subunit protein uL11m</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">39S ribosomal protein L11, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HICCMSTLAB_LOCUS13063</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subunit">
        <text evidence="4">Component of the mitochondrial ribosome large subunit (39S) which comprises a 16S rRNA and about 50 distinct proteins.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the universal ribosomal protein uL11 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5108089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HQE9"/>
    <dbReference type="OrthoDB" id="1091498at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070180">
        <property type="term" value="F:large ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00349">
        <property type="entry name" value="Ribosomal_L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.250:FF:000003">
        <property type="entry name" value="Mitochondrial ribosomal protein L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.250">
        <property type="entry name" value="Ribosomal protein L11, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1550.10">
        <property type="entry name" value="Ribosomal protein L11/L12, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00736">
        <property type="entry name" value="Ribosomal_uL11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000911">
        <property type="entry name" value="Ribosomal_uL11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020783">
        <property type="entry name" value="Ribosomal_uL11_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036769">
        <property type="entry name" value="Ribosomal_uL11_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020784">
        <property type="entry name" value="Ribosomal_uL11_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036796">
        <property type="entry name" value="Ribosomal_uL11_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11661">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11661:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL11M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00298">
        <property type="entry name" value="Ribosomal_L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03946">
        <property type="entry name" value="Ribosomal_L11_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00649">
        <property type="entry name" value="RL11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54747">
        <property type="entry name" value="Ribosomal L11/L12e N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46906">
        <property type="entry name" value="Ribosomal protein L11, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL11 N-terminal" evidence="10">
        <location>
            <begin position="26"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="Large ribosomal subunit protein uL11 C-terminal" evidence="9">
        <location>
            <begin position="88"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="13"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00040104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00041455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF03946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAG5108089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="196" mass="21893" checksum="BD49F76FE0317BFA" modified="2022-05-25" version="1">MSKVASRLKSAKKLMEKVDHSSKLHTEIPAGLASPSPPLGSQLGQRNINIANFVKEFNQKTEHLKEGIPIPCRVKVNPDRTYDLVMHKPPTSYYLMQAAGIQRGAMNSGKETSGKITLKHLYEIAKIKSEDPPLSLLTLEQITQMFVGIARTIGIQIVRDLDADEYAKFLKEREVIVAEQKKAIQEAKEAKMLRTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HRM1</accession>
    <name>A0A8J2HRM1_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Integrase core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS13139</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5108241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HRM1"/>
    <dbReference type="OrthoDB" id="7689536at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058913">
        <property type="entry name" value="Integrase_dom_put"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46791:SF5">
        <property type="entry name" value="CLR5 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46791">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24764">
        <property type="entry name" value="rva_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase core" evidence="1">
        <location>
            <begin position="130"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF24764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5108241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="299" mass="35103" checksum="3E697BB5FBC09A50" modified="2022-05-25" version="1">MPEIQSNQLIMNMLISETIRQLLICTRRLEKFTMLENLIKQYFHENYTIIQIRELLLNKHGISKSISTIKRILSALGLKRKYFKESKMEDIISAIIEEVHSCGYNLGYRSLWSLLQTCLRSKHSDKLAGNGSFIQGKSVQNQRIESYWGRMRQHTVDFYIQLFKSIQSKGLFDGSNFHIKCLQFCFGPLLKHGLDYNRRLWNEHRIRKQAARNLVAGRPNALFNLPHQHQCRDFKKLTNKNTVERLMDRFTKKPQLLDPIITELVELLVPDVKTPTNPKEALNLYKNILEAYATHRNTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HRN4</accession>
    <name>A0A8J2HRN4_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS14065</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001609">
        <property type="protein sequence ID" value="CAG5109978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HRN4"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5109978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="73" mass="8241" checksum="7543A44757509F83" modified="2022-05-25" version="1">MEQTYSDSTGVIMAITYNLTPTRAGTAVIESHFGNYHYRNPVNLEIDPTKPISLMYSNDKLVVTFSTRLIKQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HRQ2</accession>
    <name>A0A8J2HRQ2_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Similar to MFSD9: Major facilitator superfamily domain-containing protein 9 (Homo sapiens)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HICCMSTLAB_LOCUS13443</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5108807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HRQ2"/>
    <dbReference type="OrthoDB" id="440553at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24002">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 22 MEMBER 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24002:SF3">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 22 MEMBER 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="34"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="66"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="173"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="212"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="296"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="3">
        <location>
            <begin position="135"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG5108807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="322" mass="35770" checksum="9C0191B6D553CD38" modified="2022-05-25" version="1">MSAKVKWIYLAAFLDLFAVSLIVPSMGAHLKGLGASYFMIGMMTSIYALTQLLSGPGSWSDKIGRQKLFVTIYLIVGCCYPLIGLVNSYYIILLLRATIGVFKHGQQKKDEHRSKSLRQEITEAIRSLADVNWRLFGQVFALKFILDMSAGLYHSNYNLKIQERFGITPKISGYTIAFQSFVGVITGLFVAKINDKLYNSDVDYKKRNMHGYILMVVGYLGIYFASSLRVFLLWTVILKTSHMFLRIILTDMLMRKCPPSQTGSVAGTSNSVSNLARLITPVVAGVFEDTWGTNSANFLAALVASIGIFIALGISRSHPKSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HSZ7</accession>
    <name>A0A8J2HSZ7_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS12890</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5107731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HSZ7"/>
    <dbReference type="OrthoDB" id="7615508at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="209"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="260"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="332"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="413"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="778"/>
            <end position="920"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="260"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="340"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="799"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="810"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="820"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="857"/>
            <end position="868"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="895"/>
            <end position="911"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5107731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="964" mass="106635" checksum="AE27D4225BC20CCD" modified="2022-05-25" version="1">MFFGILKGNKHGSNDKHSDVNDFLRDAQQEATEEKSRAYKVAVELANSVKGDIHSRRDVSLKATKDAVISDPSVKIIEEKTVIGTEKNITAVAKTAHEIVDDVQIKAETLNKKIKDNTQGVSDNLIGTMETAITSAEVTNNKAEKDAKKVKDKNGGMFFGILKSPKHTTDSEKKLRSHRGQQNQGIKDFAGKATEEIDHNTMEEIEIIKKSTIEPSDEDTDDVGKDAKKSKDKSVGFFSGIIKGAKHVVDEVTGEVKEFWDETKEEEEKAEYARREAKESEKPAKLMSAKSGDDLDDEENMRHQMYLNLEQTLHDNADTSLYHPKSPTKVTLLLDKSGSDSESVSELDSAHSTIDHGTSPKKSSSKGKSKGVISNIVKSAKNVSHKITKEVDHVTDNIKDATEKFWEDTKIDSKDSHLSGSYDVSSPLRETDSKSVKATDLEDKLESFSSLELARETIPKDHSDMRIKSVSCIPKKTTSTTREVVKEVRVVRIEEKTSSTERLDVYDEDLVILGHLEPRAVQSVTTVVTKSVRTAVATPPPSPDELGDSSIKDITEEAAKRAQLLADQALAAGKPGHDSAEIDGTVERHVTTSAPTKQPVPAPRHSAKLSISKSELTLELDEHHQKPKSPKSKIPELSKISANICEDQLPVKQLRVSTSDSTEANQISMIPVPVDKQKSLEIVEDKVVATIQNSIIENPSIASYSFPEDIVYTKTVTTVVSSEVDQNSIKKILSTNELSQVLEDVSQDFNKFPQLAEVSNYTVKTSKAFVNERIPLSRSKEDQMSEENASGSIVKEVRSISTKSSWESSTRSRDDHDNWETQYSLDTSPGSCDAGFTKNSDSRHDLPSDSDSEGSPRQRRRSMSKRRTLGSSSGSDVALHEGAELSPMEDDQESDFLQHSEPSYMETTTTEIDPLTNERITRTTRVITSSTTVPGTEEMVGNDELRESMQKVVDQFMTEERRAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HUE8</accession>
    <name>A0A8J2HUE8_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Similar to Venom metalloproteinase 3 (Eulophus pennicornis)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HICCMSTLAB_LOCUS13894</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5109258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HUE8"/>
    <dbReference type="OrthoDB" id="7699651at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006509">
        <property type="term" value="P:membrane protein ectodomain proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001590">
        <property type="entry name" value="Peptidase_M12B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11905">
        <property type="entry name" value="ADAM A DISINTEGRIN AND METALLOPROTEASE DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11905:SF159">
        <property type="entry name" value="ADAM METALLOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01421">
        <property type="entry name" value="Reprolysin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50215">
        <property type="entry name" value="ADAM_MEPRO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M12B" evidence="4">
        <location>
            <begin position="73"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="167"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="166"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="170"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="176"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAG5109258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="264" mass="30456" checksum="FD9CCD2E52EC973C" modified="2022-05-25" version="1">MDHARRHRRSLNKSPDHESDDHGMYHIIYEIPQFQKKMPSLQLKEALTSKRTYNREIHVPETIYPEILVIVDYSMNSFMHAQTLQDKIIYLLAFWNGVDMRYRNLVNPKIRLNIARIFDYNSQNPGCDSIGLAWPSGACDIHNRTMDKVDFIQNFGNFAGVKIGAHELGHLLGVNHDNITDNGCRDGDGYIMSTSNKYTGHGFNCSRCSLQEMNRFIRSEAATCLKQESSPKGKPLFRFLPEKLMNIHEQCDVNEYGSRNLISR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MBM9</accession>
    <name>A0A8J2MBM9_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Splicing factor YJU2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HICCMSTLAB_LOCUS3442</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Part of the spliceosome which catalyzes two sequential transesterification reactions, first the excision of the non-coding intron from pre-mRNA and then the ligation of the coding exons to form the mature mRNA. Plays a role in stabilizing the structure of the spliceosome catalytic core and docking of the branch helix into the active site, producing 5'-exon and lariat intron-3'-intermediates.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the spliceosome. Present in the activated B complex, the catalytically activated B* complex which catalyzes the branching, the catalytic step 1 C complex catalyzing the exon ligation, and the postcatalytic P complex containing the ligated exons (mRNA) and the excised lariat intron.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the CWC16 family. YJU2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5082040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MBM9"/>
    <dbReference type="OrthoDB" id="674963at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071006">
        <property type="term" value="C:U2-type catalytic step 1 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000349">
        <property type="term" value="P:generation of catalytic spliceosome for first transesterification step"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03226">
        <property type="entry name" value="YJU2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007590">
        <property type="entry name" value="Saf4/Yju2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043701">
        <property type="entry name" value="Yju2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12111">
        <property type="entry name" value="SPLICING FACTOR YJU2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12111:SF1">
        <property type="entry name" value="SPLICING FACTOR YJU2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04502">
        <property type="entry name" value="Saf4_Yju2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="5 8" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="115"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="46"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="80"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="83"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAG5082040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="151" mass="17591" checksum="C4F4322485E6A7E6" modified="2022-05-25" version="1">MSERKVLNKYYSPDFDPSKIPPMKLAKNHQYTVRLMAPFNMRCKTCGEYIYKGKKFNARKEDVEGSDYLGIRIYRFYIKCTRCLQEISFKTDPKNTDYEIEAGATMNFMALKLAEEQAKREEDEKNEEEASNPMKLLEKRTQQSKQGAGGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MGT1</accession>
    <name>A0A8J2MGT1_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Similar to Zrsr1: U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit-related protein 1 (Mus musculus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HICCMSTLAB_LOCUS3354</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5081690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MGT1"/>
    <dbReference type="OrthoDB" id="75923at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0089701">
        <property type="term" value="C:U2AF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003954">
        <property type="entry name" value="RRM_euk-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009145">
        <property type="entry name" value="U2AF_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12620">
        <property type="entry name" value="U2 SNRNP AUXILIARY FACTOR, SMALL SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00642">
        <property type="entry name" value="zf-CCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01848">
        <property type="entry name" value="U2AUXFACTOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00361">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="12" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 7" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="11">
        <location>
            <begin position="160"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="10">
        <location>
            <begin position="216"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="7">
        <location>
            <begin position="160"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="339"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="21"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="340"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="400"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="420"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="436"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="494"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAG5081690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="494" mass="59883" checksum="7F2735D7686EBC94" modified="2022-05-25" version="1" fragment="single">MEEYNCEKVKLRHKEWRKIVKKERRKRVRQKTAQLRDAEEKQLQVALERSAGYLNWLLEQKLLQEEKERKKAEELAEQEKQWLENERKARARAEQLRQEEIIRKEFEEKQEALKKKREEIKRLQDEEINRQVQLEKEIDDYIDNGVRTPEYLRLTSDTHPTKEPCVFFTKTGACKYGDACSRNHQRKSLTKVILIPGFYYHFSLEKNSNEYDTDVGLEFESSETRNHFREFYKDVVPELESFGRIRTLKCCFNSDIHLRGNLYVEYETEREAARAWRKLRSRWYAGRQLNCEFANIVSWRNAVCGMFHCPKGRGCNFIHAFRNPGDEYDIKSPPWRAVRANRESTNSRRDRMEEESRRRDDTHRNWRWSESPEVEMEDISSKKEKERLKSRRRSETPSSRSERHSKGRDSRRDKKTSRRHSSESRYDYFKKKKRRSDKDKENGELRENKLRKKSKEDMARKSDRDKENGELKENKLKKKVKEDIKTKSRDYVDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MI99</accession>
    <name>A0A8J2MI99_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS3625</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5082679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MI99"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13920">
        <property type="entry name" value="zf-C3HC4_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5082679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="101" mass="11945" checksum="95498E320333A3C4" modified="2022-05-25" version="1">MNLIFYICHVVKEVLLRAFPIDDEPNDTFDEEEEDQWYIYSQHCLGCYEDGIEIGYKPCTHAPYCRSCNKKWHDEAIRTGEIFTCILCQSAVEIMEDLRKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MJJ6</accession>
    <name>A0A8J2MJJ6_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Similar to nat9: N-acetyltransferase 9-like protein (Nematostella vectensis)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HICCMSTLAB_LOCUS4598</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the acetyltransferase family. GNAT subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peroxisomal membrane protein PXMP2/4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5087747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MJJ6"/>
    <dbReference type="OrthoDB" id="430207at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007248">
        <property type="entry name" value="Mpv17_PMP22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039135">
        <property type="entry name" value="NAT9-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13256:SF16">
        <property type="entry name" value="ALPHA_BETA-TUBULIN-N-ACETYLTRANSFERASE 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13256">
        <property type="entry name" value="N-ACETYLTRANSFERASE 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13302">
        <property type="entry name" value="Acetyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04117">
        <property type="entry name" value="Mpv17_PMP22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="244"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="283"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="321"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="345"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="domain" description="N-acetyltransferase" evidence="10">
        <location>
            <begin position="14"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF13302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAG5087747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="425" mass="49507" checksum="EA0F3F85EA12AE83" modified="2022-05-25" version="1">MKINENTRIVGSKVVLVPYKKKYVERYHQWMKSEELQYLTGSEPLTIEEEYQMQESWHNDDNKCTFIILDRNRFDKTNPVDSMIGDTNLYLNDIEEPFTAECEIMIAEKCARGQKMGWEALILILRYGIEALKINKYRAKIKIDNEKSIKMFNKLRFNEISRSVVFEEVTLECDATAIKFRPLFFNSVAYGSFYTGAEFLQQTYNINQKEKAAAVLNNTPVNSNKLFPDKFKLEDYNVPVLRRYLTYGYFLAGPILHGWYSWLDKMFKGTAPKIVVTKLLCDQFILTPPLVVLFFTSMSVMEGKKTENLLDECKAKFVKTFATSCIFWLPVQFVNFLLIPPSFRVLYVSVASFCWVNILCHLKLNFLFNVTATAYNRIGIDDFNQCDVLSWVMTIFKVGNYHKNAIKTGLCKVFTNISRRDFTTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MKM1</accession>
    <name>A0A8J2MKM1_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Similar to LRRC59: Leucine-rich repeat-containing protein 59 (Homo sapiens)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HICCMSTLAB_LOCUS3566</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5082452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MKM1"/>
    <dbReference type="OrthoDB" id="1394818at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050216">
        <property type="entry name" value="LRR_domain-containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051:SF1">
        <property type="entry name" value="RAS SUPPRESSOR PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="218"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG5082452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="316" mass="35687" checksum="04D5CEC59E172F65" modified="2022-05-25" version="1">MTNKIKVKDKLEDDTLDLSYCDLREVPIREIAPIKKATCLDLSNNSLVSIPNTIVSLTNIIKLDLSKNMLTEIPENIGEMRQLRHLDLYSNQISRLPLSLGELKNLKWLDLKDNPLTAAVASVAGPCSNSSDCQACAKNIVSYLSQVKQSIEEEKVRRKAVVADVPAKKETKKKKKKNAEKIIKVSPATEAIVAEENNGEPEHETVSPKKTTRGTCSIFINILISGILATLLFSIFFVLILIFLPSYNKDLSDIIVKDLEAQTKLPVKYYQELGIVKKDFIFKEMFIFFNKSKLVGAKYYNEIVSYLSVKFNEYFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MLH3</accession>
    <name>A0A8J2MLH3_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Gustatory receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HICCMSTLAB_LOCUS6331</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Cell membrane</location>
            <topology evidence="1 8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the insect chemoreceptor superfamily. Gustatory receptor (GR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5092709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MLH3"/>
    <dbReference type="OrthoDB" id="10292962at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030425">
        <property type="term" value="C:dendrite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043025">
        <property type="term" value="C:neuronal cell body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007635">
        <property type="term" value="P:chemosensory behavior"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008049">
        <property type="term" value="P:male courtship behavior"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050909">
        <property type="term" value="P:sensory perception of taste"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013604">
        <property type="entry name" value="7TM_chemorcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21143:SF133">
        <property type="entry name" value="GUSTATORY AND PHEROMONE RECEPTOR 32A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21143">
        <property type="entry name" value="INVERTEBRATE GUSTATORY RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08395">
        <property type="entry name" value="7tm_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 8 9" id="KW-0675">Receptor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="141"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="175"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="255"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="295"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAG5092709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="410" mass="47840" checksum="5060B02152AFE21F" modified="2022-05-25" version="1">MKFTCNIFISEIQLYRVLLKFFKILGLAPFNVHLIPSAQNKKEQQFDINYTYSFEESVYDFILSVCLLFKIIYDFVHQHFENPYQHLYDIVNNFSLMMIITSYCLKQQLSVKIITNLTYLETELACKSWDYSFKITSVKKYCIAITIFFTINFIAIIVFHALWSTNQTIETYITLSSLFITEVCVIQYASVMIYLYQRLKTLNSSLLVFANNNNGFDYLGLWTNSIRNNITNQKLIFLRQAHRLLYNCLCDTTKFYSVPILFAVLSNFPILLLSVELLIRTKFTSEELFNMGLHYFGTGLLIVFSLVPISILCFFVTKIITEMKRTKDNVSKIITVRSSDDSFKDELEKFYIELLHANYNITACGFFKIDNSLLSLIFTGIIVYCFTVNIKQAHQEENEGFLLSSFISII</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MMB6</accession>
    <name>A0A8J2MMB6_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">m7GpppN-mRNA hydrolase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">mRNA-decapping enzyme 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">HICCMSTLAB_LOCUS4083</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="14">Decapping metalloenzyme that catalyzes the cleavage of the cap structure on mRNAs. Removes the 7-methyl guanine cap structure from mRNA molecules, yielding a 5'-phosphorylated mRNA fragment and 7m-GDP. Necessary for the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay. Plays a role in replication-dependent histone mRNA degradation. Has higher activity towards mRNAs that lack a poly(A) tail. Has no activity towards a cap structure lacking an RNA moiety. The presence of a N(6)-methyladenosine methylation at the second transcribed position of mRNAs (N(6),2'-O-dimethyladenosine cap; m6A(m)) provides resistance to DCP2-mediated decapping. Blocks autophagy in nutrient-rich conditions by repressing the expression of ATG-related genes through degradation of their transcripts.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in mRNA + H2O = N(7)-methyl-GDP + a 5'-end phospho-ribonucleoside in mRNA + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:67484"/>
            <dbReference type="Rhea" id="RHEA-COMP:15692"/>
            <dbReference type="Rhea" id="RHEA-COMP:17167"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:63714"/>
            <dbReference type="ChEBI" id="CHEBI:138282"/>
            <dbReference type="ChEBI" id="CHEBI:156461"/>
            <dbReference type="EC" id="3.6.1.62"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:67485"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
            <location evidence="4">P-body</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the Nudix hydrolase family. DCP2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5084352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MMB6"/>
    <dbReference type="OrthoDB" id="18996at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140933">
        <property type="term" value="F:5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000290">
        <property type="term" value="P:deadenylation-dependent decapping of nuclear-transcribed mRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000184">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03672">
        <property type="entry name" value="NUDIX_Dcp2p_Nudt20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.1050:FF:000001">
        <property type="entry name" value="M7GpppN-mRNA hydrolase isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.79.10:FF:000003">
        <property type="entry name" value="M7GpppN-mRNA hydrolase isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1050">
        <property type="entry name" value="Dcp2, box A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007722">
        <property type="entry name" value="DCP2_BoxA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036189">
        <property type="entry name" value="DCP2_BoxA_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044099">
        <property type="entry name" value="Dcp2_NUDIX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23114">
        <property type="entry name" value="M7GPPPN-MRNA HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23114:SF17">
        <property type="entry name" value="M7GPPPN-MRNA HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05026">
        <property type="entry name" value="DCP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01125">
        <property type="entry name" value="DCP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140586">
        <property type="entry name" value="Dcp2 domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 19" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0464">Manganese</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="18">
        <location>
            <begin position="94"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="243"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="261"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="288"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00005279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00060003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00068566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00078183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="CAG5084352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="409" mass="47764" checksum="D9D3731EF6AC2E6B" modified="2022-05-25" version="1">MAQRAIPSDILDDLSSRFIINIPEEDRKDLVRICFQIELAHWFYLDFYCGDEPSKLKSCSMKEFSVHLFRHIPFLRAHLPHLDMILEQWREYKQSVPTFGAIVLNEDMSKVLLVQNYWSKNSWGFPKGKVNEDEDPSHCAAREVLEETGFDISSFIDKNDFIESIINDRLVRLYMISGVQKDTKFQPLTRKEIKNVEWFALNDLPNTTKDMTPKVKMGVGPNAFFMVVPFVRRMKRWVFEKQQHEKQLSKRNRHKSLGDVESTNAIELKNQRQSNTSPARNRRPGNVKSVTKNSPGDSEGAGSSNKNNSTKQAIKRNLFGDSNKIRKSSTVLAKELRDSPCEFHYYKEEINKKEKVDYDIENIESYFTHLKKNDEDDVFENVDDDEFSYKPSAWTQFKFDKQTILSCIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MMC0</accession>
    <name>A0A8J2MMC0_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to Notum: Palmitoleoyl-protein carboxylesterase NOTUM (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS7259</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the pectinacetylesterase family. Notum subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5093933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MMC0"/>
    <dbReference type="OrthoDB" id="2015280at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004963">
        <property type="entry name" value="PAE/NOTUM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21562">
        <property type="entry name" value="NOTUM-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21562:SF122">
        <property type="entry name" value="PALMITOLEOYL-PROTEIN CARBOXYLESTERASE NOTUM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03283">
        <property type="entry name" value="PAE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50007">
        <property type="entry name" value="PIPLC_X_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="477"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="19"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="482"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="562"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="580"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="607"/>
            <end position="620"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5093933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="1081" mass="122890" checksum="DA4B36C1672F0F7C" modified="2022-05-25" version="1">MRRDHIMPADRIGKRRRGEKQVKNEKNNKDPALFWRTPRVTALLVSPMRLANSPQVPTNSSTSYRSSCSTLLVSVQGIPPVIVLVAINRVHFKATNLNKIAVCLIVLASVSCEDSASSGDSNSAVPVTASNTIQKLRKILEKFGEEQQRGLKRVFLSNRSITCNDGSQAGFYLRKSHGSKKWIVFLEGGWCCFDQKTCRHRWIKLRNYMTSTNWSETRDVGGILSLNPQENPYWWNVNHVYVPYCTSDSWSGTRSFPNEMFSFMGAEIVSQVIRDLVPLGLDTASSLMLAGSSAGGMGVMLNLDRVQNLIHHELGLTNTVVRGVSDSGWFLDQEPYPPSGGLLPGETVKMGMELWRARMPTNCVAQYPKEPWKCFFGYKLYPTLSTPLFIFQWLFDKAQMKFNNVGTPLSKEQWDYIHRMGRIVRQTLDNVTAVFAPSCISHNVLTAREWQQVKINQVTVPQALHCWERSFSHRSHGFSSSTQVETNQTCTRPITNPSLRTNETKKNTTLATSAVSGNNDNGRKDDDTGVNIKQNINVLGRKNRVKGTMSHNNNGSIDGRGNKKRKRRRKHKDNKRQRERNRNGKNRERKDKRQRRKEERKKNNNKYISGNNHRTMLNDTRPQRSLLPSGNKKEIKCIAHNCHHRHTDNCSWPQCNHSCPKLHNPFTGEEMDFIELLKSFGLDMKSVAIALARSTQCGKVWLTVSSLWRPIAASDKVIDAELEVNWDLDCPTNIEPPDTIKVFNADPIHNKSLQPELILTLAEHPEGYYRTNIEVGRPSLPGGWDATGGATLPGPHCLKHYAALYKNNIFLTSSCLQIWPTWMYDLRRQLGRLPIGSLMIPGTHNSGCYKHEDLTRKDAFQKYLLTQDRDVWTQLVHGIRYLDIRVGHYPPPMHNGSHSADDANHTSGRRLAIMLYREFGGLILKPSRGVDGLGPTLNEIWNSGRRLIICYGDKHTVNEFDWLWPPLTQVWGNQQTAQGLFEYLNSVIMGPERKPRNTLNPLWAIMAELTPRPFDIIFNPNGAGLRQMADAVNRNLSSLFQNEWWKQTNIVATDFFLGNNLIQVSIQSNIKKSNIAQWSFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MMV4</accession>
    <name>A0A8J2MMV4_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS8316</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5096651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MMV4"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="343"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="449"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="125"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="162"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="191"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="202"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="242"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="269"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="374"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="394"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5096651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="471" mass="52506" checksum="DB436C631DC97238" modified="2022-05-25" version="1" fragment="single">YKFNVVVRHKITEQYAEGLSYNPERRQEPREHPINDTTENHSLALPISALSKTKKSNKKLSDEEAIQSVKRPGHPLGSKNRPRVSSAPEVRETIASRLRKRELGKTRVPPKINYRETGRLVINSEDPESQETANEEQGDDEVFLPVSISGPSTNNPTPDVGQEGDDEAEKDDEAEKDNETTVPQKQRRKTRELYAEIKRTSSDTAKNIRQSLNKLPPLWRSEDDSLNEDTAPEINVDEFLRDNSNQSEEGSSNISPEETGGIEDPSETEPPIIIEPEPSTLVNNVNTRNKNNLTPQNANRSRFTGYLGDGPEPRTPIFGRVLIPDELAAMGIRYDHASGQIVDENGKGINETAETESADPDNTLTESEGRRSNEQSPNISKLINSQNSKNKSRKNSENSSDPHKPNDRPTTSGNITVGDEVGNHRFGPPFIAYDLPTFEEAEDIFAERHLRPKLSSPSSSDENILPKGPEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MN00</accession>
    <name>A0A8J2MN00_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Similar to SETX: Probable helicase senataxin (Homo sapiens)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HICCMSTLAB_LOCUS6954</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5093618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2285229at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016604">
        <property type="term" value="C:nuclear body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001147">
        <property type="term" value="F:transcription termination site sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006369">
        <property type="term" value="P:termination of RNA polymerase II transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18042">
        <property type="entry name" value="DEXXQc_SETX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00060">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18808">
        <property type="entry name" value="SF1_C_Upf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000326">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045055">
        <property type="entry name" value="DNA2/NAM7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041679">
        <property type="entry name" value="DNA2/NAM7-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041677">
        <property type="entry name" value="DNA2/NAM7_AAA_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047187">
        <property type="entry name" value="SF1_C_Upf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887">
        <property type="entry name" value="DNA2/NAM7 HELICASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887:SF495">
        <property type="entry name" value="HELICASE SENATAXIN ISOFORM X1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13086">
        <property type="entry name" value="AAA_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13087">
        <property type="entry name" value="AAA_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 8" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA2/NAM7 helicase helicase" evidence="6">
        <location>
            <begin position="1440"/>
            <end position="1711"/>
        </location>
    </feature>
    <feature type="domain" description="DNA2/NAM7 helicase-like C-terminal" evidence="7">
        <location>
            <begin position="1719"/>
            <end position="1909"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="183"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="456"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="663"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="740"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="886"/>
            <end position="910"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="925"/>
            <end position="1046"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="183"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="206"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="225"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="238"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="479"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="519"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="569"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="637"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="702"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="795"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="807"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="834"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="925"/>
            <end position="942"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="951"/>
            <end position="962"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="972"/>
            <end position="982"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="996"/>
            <end position="1007"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG5093618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="1955" mass="220523" checksum="E6FCC63ABC4E5085" modified="2022-05-25" version="1" fragment="single">MNGFYLEPVGSHNGIPLPDFKGYTCGRQRTNDIMLNSSANGTYINGQRVQAKVFHTVHIGNALGISCHKTEDDEFEENEIRFVYRLRRLPVDYSKKMNGNLKDEVGEKRKSNGKSPVPYKVARLENVEDGYVSDDDCIMIEDDPVPNVQPEPRLPIIQPSTSALQVAQQNSLIKYELDIPEEGEEKEVASEENLEINNRPDRKDSAQTSTTNSIVNGSTSRNEESSLAARSSSLLNDEANSNDIFSDSPASSPKIAAKNPNESVIVKQEPKIKKDADASVDVIQIDNDDVVVFPASQLFDDEEAASSDDNNTTVDAAPVSSIIKEECDLGTDDIDCYNGLSSEEAEESEYPVIVLSDDEDEYDSTRDPWLMKLSGSQLESRSSSEIESLKLKEELIDQTDDKEDEIVNGLLDSLEKEEFVMETEDAEMSDGVTTSEDMVTDQIEDVKEPVKLTEAAAAVAIPESVEEKDVKKEKKDKKNKIPENRRKESHSKPRDKSKNRKSERDSGSKDLSKQLIDTYEFRTSFEEPKPGPYQSTKKGEEGKKIKKIVIRSNIEFKTPIVKSIIADEMLPRTSKESKVDKNEKPIEKDGKEERKDKGAIKKHKVVQEEPKDQVRVEDKIKRAEKDKPKNKKKNKNQKKEEHKKTEEKVALIPFEEALMEGDKITIDDKKKIKKRKTSQESSEERKSDEPVASTSAGAAETLSKEPAKAEIETKTLVIDGRRVSISKKVKKKIKTIEPPIFTRGGRHGVSATLSASDAALNTPKASDEAGLSPPTGTDNQEEDYNSDLFSKPTKLANSSKSNNPMEQQKDRLRRSFREKEILKNVKSIHKAKSKRENKDFREDRKERLKQLTEKPKGNDDKTASKRVSKVVVKVSKNRGMFLVPEGVNLDDSKDEDAAKKEPVKINNGPTFDLHVEGIKNNHINANSTTVDDLSDVISTNSVPGYPEPPPQEDKDTDSDSSHDMNAITDPGLNDDIDMEDTLMDYIDTPTTSNGRSASSSPDDYSPPKINYSRQIRKVSPKPFTPQVNQPFSRPPAASRPSNLPFHQPSRLIRSILKKAPERGQANYLPNGISCNNLPQIGKPKKRIRFATTPPVVHLIDILPGNKLIRKCIQKDAAMPKTAAIQNTLPGDPSTYLPNLSTIATPKALPAPPSAPAPVHQNALTSRHLVTNIYNEPRRISGPQLDEFLLRVFDWNPQWLDPEAYDQRSQRNLPIVPAGQMPHLSSYANYSDYYSIMADLMMLEMWAGIVRESNDREFMKARRNMHAVIGQNSITQTPIRSTNHTLTVFTADILCSKSQIDSRQHATPGELVMLELPIVVENEIHFRPIFAYVKDYQKTVITPSSTPYNKYLQNTVPNPYAVVTLTMSTKSLPLNIKFNRVLRMKTRFYMRPNLRMVQAILHLPSNPLLHHIIQPDVKKEGYELTKVTKFDNYKFATGDALNERQMEAVLSVTNAVLEKKPKICLVEGPPGTGKSRVIVNIITEIMYGQNRYANNDRRRILVCAPSNAAVDEITMRLLEIRAKFQRENSRDLFRLVRVGNTKMMHPRVKDISLSELVDRAWAAKGPGDVSADNEINRLQQHIIELKATMGSFTQPIPEGDRIKLKKRLEDWTNQLALLQASKQVRHLHSGKRAYLENKLLSTADIITCTLSSCYTQPMELAFGNRSSKKISVCIVDEATQSTEPETLIPLMLGVLKLVLVGDPQQLPATVLSSRAKELNYDKSLFSRIHEKFMSELENPIISLNTQYRMAHPIVYWPNRFFYSNQLQSSVKPIVWPYSPYKVFNLTSVQDNNQFSNSDEATYVVNLIHAIVTGANLDKVEGVIRIGVITPYQDQRKIIQRKMEEKFTSVPDNIKNRFIRQVSTVDGFQGQEREIIIMSCVRSNGIGFLTDRQRLCVALTRAKHSLFLCGNFKTFEKDETWGALIKDARSRNFYINTDHRTDQERIKQNIIKLAFMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MNT0</accession>
    <name>A0A8J2MNT0_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Similar to RhoGAPp190: Rho GTPase-activating protein 190 (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HICCMSTLAB_LOCUS10029</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5100956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9994905at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050770">
        <property type="term" value="P:regulation of axonogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008361">
        <property type="term" value="P:regulation of cell size"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007266">
        <property type="term" value="P:Rho protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22207">
        <property type="entry name" value="pseudoGTPaseD_p190RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.440">
        <property type="entry name" value="FF domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002713">
        <property type="entry name" value="FF_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036517">
        <property type="entry name" value="FF_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057284">
        <property type="entry name" value="FF_RHG35_4th"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039007">
        <property type="entry name" value="pG1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051978">
        <property type="entry name" value="Rho-GAP_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032835">
        <property type="entry name" value="RhoGAP-FF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045786">
        <property type="entry name" value="RhoGAP_pG1_pG2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039006">
        <property type="entry name" value="RhoGAP_pG2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46005">
        <property type="entry name" value="RHO GTPASE-ACTIVATING PROTEIN 190"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46005:SF4">
        <property type="entry name" value="RHO GTPASE-ACTIVATING PROTEIN 190"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23083">
        <property type="entry name" value="FF_RHG35_4th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16512">
        <property type="entry name" value="RhoGAP-FF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19518">
        <property type="entry name" value="RhoGAP_pG1_pG2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81698">
        <property type="entry name" value="FF domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51676">
        <property type="entry name" value="FF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51852">
        <property type="entry name" value="PG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51853">
        <property type="entry name" value="PG2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="FF" evidence="5">
        <location>
            <begin position="433"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="domain" description="PG1 pseudoGTPase" evidence="6">
        <location>
            <begin position="600"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="domain" description="PG2 pseudoGTPase" evidence="7">
        <location>
            <begin position="791"/>
            <end position="951"/>
        </location>
    </feature>
    <feature type="domain" description="Rho-GAP" evidence="4">
        <location>
            <begin position="1430"/>
            <end position="1634"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="959"/>
            <end position="1014"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1085"/>
            <end position="1108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1184"/>
            <end position="1239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1259"/>
            <end position="1301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1337"/>
            <end position="1356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1364"/>
            <end position="1422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1085"/>
            <end position="1104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1196"/>
            <end position="1205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="1218"/>
            <end position="1233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1260"/>
            <end position="1275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1337"/>
            <end position="1352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1373"/>
            <end position="1409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG5100956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="1643" mass="187244" checksum="140EC611479A25F7" modified="2022-05-25" version="1">MSFNMARKSDNVKCINIAVVGLSGTEKDKGQVGVGKSCLCNRFMRSLSDDYSVDHISVLSQSDFSGRVVNNDHFLYWGEVTKVAEDGTEYQFQVIEQSEFIDDASFQPFKGGKMEPYAKRCTATKITSAEKLMYICKNQLGIEKEYEQKVLPDGKLNIDGFLCVFDVSVVPNRSIEKQIEIVSNILNNLIKTKKPILLVTTKNDDANEQYVKEAEKLISRKEYKSSISVVETSSHENINIDAAFLVLAQIIDKTKVRSKIIPFSEAARLRKELLDASTESLQRLIRIHVTDYRALWSQASKKLAQHKEFNNFVELFGIDATQRLFRRHIKKLKDEQIAKKIQGYLDMLPDILHEICPDISSLINEEWSTVQQFIKEHPDFHQHFYECPEDISWIDYDFGENNTSKIPYEVLETPEAETVFKNHINALQQEQRRLEWKKQFKQLLEETGYVTPGKHLSEVRVLFMGRECFEALSHHDCQEIYEQHQKEIIERAKHNFQELLLEHADLFYHFKSIAPSGTITQDDIKEITDALIDDFRYKTLDRLDQDRKLMLFQHLGFVHCPIREHCPAFPNCMDALIERILGTKAHRPSSWNHSSQWQLTSENNQLNLVILGSNGLGSEFAQEIKMQTDDDEVEIDCQLYTLGYRVIDGDVGLPHNSFTTSDFMPHGSFCIYANEDSFEYIRLSLEKTLLSNLEQEDRLPFQGLPIVIMFVPDITIDEMEAMRLREEGQNLADSLQCPFIDVCVEDLEPDKRFPHSLVKEALQQLIQSINHRAGFLNIYQSVIECLEPDIRIIMCMFCGDPYSVENVLGPLLSHQCCFLSGEKSIVLETFLGDSKRRVEVIISSFHGANAFRDELVHGFILVYSTKRKASLATLNAFSMNIPNLPIQIMAVTDTGGANAFFSNDLSHMLITEGNATADRLQAHFMTSASSCQQKTAFYTPFFKEVWEKKPEIEQAFNMEEPGNLNDSGEGTLEYSALHPMPPPRHESYHLQTPDDGSGSESYEQLTPDGELGDTVLNEQFNDHRATPSDDSDIYSQVDFHREERERELLKGGDFANKLTGWVKDTFNMHHDGVSNTYSHRAFTTGRRNISQTKSRPKGNSQTLKQPGKINLKDFSNVTDAIARMSVGEKMEHGSKMMGHAPLATPELVDLEYAHPKDVVTNLYPAYEGEYAYALVQDSISNNKSKLRHRREKGQPSYSDSDSEWSSLERQRADALSKTNKKPSSYKRTRKKRTAIPVATPKVPSLASMVSGDGSIGINFTKDDKNWRIDPTERVSSETPDSSESSEPEHGTRSRLKPNKHAGAVSVRKRFGNSAATLQHPFNLKHVTQDMFSVSYDESSLDVSSPREINSPSFGILTKGKECDKLTRKKDKQKAKEDEKLEKRRQKEEKLKKHAEKEREREKKKQEKIKQTKGPGGTGGAGVSLTGQSQLSLIEDFAQSETNRIPLFLEKCVRFIEEEGLDSEGIYRVPGNRAHVELLFQKFEEDGNVDIHLLDIPVNAVATALKDFFSKRLPPLIDKERMIELENISGARGTSKPMSATGMNMEDPSCRLLALRSMLNQLNPVNFNVLKFIFQHFVKVAENCKLNSMDSKNLAICWWPTLLPIEFNDLGRFEAMRPYLEDVVQTMIDQYPFLFCDKEAIVMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MPK5</accession>
    <name>A0A8J2MPK5_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Odorant receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HICCMSTLAB_LOCUS10782</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Cell membrane</location>
            <topology evidence="1 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the insect chemoreceptor superfamily. Heteromeric odorant receptor channel (TC 1.A.69) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5101972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MPK5"/>
    <dbReference type="OrthoDB" id="7548151at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005549">
        <property type="term" value="F:odorant binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004984">
        <property type="term" value="F:olfactory receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004117">
        <property type="entry name" value="7tm6_olfct_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21137">
        <property type="entry name" value="ODORANT RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21137:SF35">
        <property type="entry name" value="ODORANT RECEPTOR 19A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02949">
        <property type="entry name" value="7tm_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 10" id="KW-0552">Olfaction</keyword>
    <keyword evidence="8 10 11" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="9 10" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="130"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="181"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="257"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="290"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU351113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAG5101972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="383" mass="45130" checksum="31A89C45C38CC68D" modified="2022-05-25" version="1">MSETKMSRLEIINSVPFDEFFNAEIRMLRYMGLLHFKCIYFQVKKNLNIVALIQIIAYDITLAPEMFTALLSASLCCFKALRCWTHRKELFDFIRKLKVLWEDASSKQFMTEPILDSALYAKSLRNQLTVGLLLLVVTYGFFPYVVFIDHFISHRDEYFFNFSIIIYPISYPFTVNTFPRYFICLIFEQTILLLCYIYWLCGDVMFIQLTTHQIDCLALMELHSMILQIIKIMKNYETLHRNITNSICTYCQWLQRFFSPIVLFVTLINAANLCFSLFRVDQEINQKNWSGLLVNAIHLLAVLGQTILYCMHAEMLTVKLEAIYFCDWTGSSKKFKTMVLMIMKRAHKEYKFTVYGIITFNLNQFTKIVNAAMSYFTLLRSFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MQ00</accession>
    <name>A0A8J2MQ00_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">DNA polymerase eta</fullName>
            <ecNumber evidence="5">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">HICCMSTLAB_LOCUS10060</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the DNA polymerase type-Y family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="5"/>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5100987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MQ00"/>
    <dbReference type="OrthoDB" id="5723at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005657">
        <property type="term" value="C:replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042276">
        <property type="term" value="P:error-prone translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009411">
        <property type="term" value="P:response to UV"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1170.60:FF:000003">
        <property type="entry name" value="DNA polymerase eta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.20:FF:000014">
        <property type="entry name" value="Polymerase (DNA directed), eta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1170.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.100">
        <property type="entry name" value="DNA polymerase, Y-family, little finger domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036775">
        <property type="entry name" value="DNA_pol_Y-fam_lit_finger_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017961">
        <property type="entry name" value="DNA_pol_Y-fam_little_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052230">
        <property type="entry name" value="DNA_polymerase_eta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041298">
        <property type="entry name" value="UBZ3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001126">
        <property type="entry name" value="UmuC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45873">
        <property type="entry name" value="DNA POLYMERASE ETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45873:SF1">
        <property type="entry name" value="DNA POLYMERASE ETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00817">
        <property type="entry name" value="IMS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11799">
        <property type="entry name" value="IMS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21704">
        <property type="entry name" value="POLH-Rev1_HhH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18439">
        <property type="entry name" value="zf_UBZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036603">
        <property type="entry name" value="DPol_eta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100879">
        <property type="entry name" value="Lesion bypass DNA polymerase (Y-family), little finger domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50173">
        <property type="entry name" value="UMUC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51907">
        <property type="entry name" value="ZF_UBZ3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0227">DNA damage</keyword>
    <keyword evidence="13" id="KW-0234">DNA repair</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="11" id="KW-0862">Zinc</keyword>
    <keyword evidence="10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="UmuC" evidence="18">
        <location>
            <begin position="9"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="UBZ3-type" evidence="19">
        <location>
            <begin position="584"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="518"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="618"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="518"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="557"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="618"/>
            <end position="631"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00044975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="CAG5100987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="657" mass="73540" checksum="D78F1C63E0F017D3" modified="2022-05-25" version="1">MATSEDRIIALIDMDCFFCQVETREHPEFKGKPLVVTQFNLVLAVNYEAKALGVSRFVSGNKAKEQCPELELISVPILRGKGDVSKYRAAGQEVIDVLKDHCPVIERASVDEAYLDITSLVEDKIDSITCSSKEVISKLNNTFVVGYCGDDNDEEKRKDGLDTWVRESFDDLGDIQARKLAVAGMIVEELRTEIFNKCQFRCSAGISYNKVLAKLACGLHKPNKQTILPATSVPRLFSSLPINKVRSLGGKVGKDVVESLGCNVMADLLKFSLQDLQKHFDQKTGIKLYNIARGIDHEPVTPRLICKSIGASKNFSVKQAITDLDSLKQWVDSLTDDVCNRLEQDYEENHRRASNLTISYQYYQNGKSISQSRTLPLAGYKANRIASQALSIISKSIDKPIVALSIAGGKFIDAQNDGSFVNYFKTIQKQSQQANSDFRQESDENLDLGNFDSEDCDVEGIEKVSLEENYVDTVVESRINVKLREIFPDLENIDPAVVELLPSELQQAARVYLKSDNKVPDNVKSSQDKIKNEEKLKPVSIKSPQNKVKNGKKYVKSKSSNSNNKSCEKNQSNINKFVVKNNNDTSMMIRCSECNQMILNEKYLEHCDYHVAHNLQKNINQPSNSGTSSANKRNRDAGSTPKSNKKKKSIKSYFCSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MQ27</accession>
    <name>A0A8J2MQ27_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Endonuclease/exonuclease/phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS11192</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5102804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MQ27"/>
    <dbReference type="OrthoDB" id="7699805at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="21"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5102804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="572" mass="64716" checksum="F19CAFA37AB234AF" modified="2022-05-25" version="1">MNLQVNADSISKLDEELTEMKTKMVTNKQSIEEKLSNLENSISANRATATTMLPATRSAAELIISGIPDPIIDKLSHVDISILSHLNLPHSTNDILSSRKLENKTKSNTHKTGNEDSPNLHLFLRKYLSQRILTTGNLQITAYHQGKVPDHEVQVIRRGRILKHADIGNYIRGGGEACLIHNSLRVKVLHISASNHLNQPEFLIVDVTLRNSCHLLLSCIYRRLKGMLLTEFFNVHSKLAPNYKNIIIAGDLNCNLLENSYTANHLKDFIIEFSLHCISYNATFHKNDCDSWLDVILIDIATKFVSFAKSDSSFTDGHDYLLCQYKVDQLQQIKILKTDQQVLATSLFNSLTLDNSIVENLDPNDLTIFKSNVLSTLDLHAPVLTKSITQLTFARESYLKSALSSLPYGSTVWSKLRNLGLTKSNSSSPLNFFDARELNEYYANIVRKHATTSKEFLNSLPTCYQRQVESSFHWQKIDVDVTKVLQSTLSKSKGKSPDGLDLRWLRDYIRQINFSLLPCSTDLLTTALTPNFNSKFVFSGKKYVGKHMSHTQHRPLSFFVDLCNLLQVWTVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MQ89</accession>
    <name>A0A8J2MQ89_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Selenoprotein M</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HICCMSTLAB_LOCUS5202</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the selenoprotein M/F family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5089349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MQ89"/>
    <dbReference type="OrthoDB" id="25165at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.50">
        <property type="entry name" value="Sep15/SelM thioredoxin-like domain, active-site redox motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038219">
        <property type="entry name" value="Sep15/SelM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039992">
        <property type="entry name" value="Sep15_SelM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014912">
        <property type="entry name" value="Sep15_SelM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13077">
        <property type="entry name" value="SELENOPROTEIN F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13077:SF7">
        <property type="entry name" value="SELENOPROTEIN M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08806">
        <property type="entry name" value="Sep15_SelM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0712">Selenocysteine</keyword>
    <keyword evidence="2 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035282730" description="Selenoprotein M" evidence="5">
        <location>
            <begin position="22"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="Selenoprotein F/M" evidence="6">
        <location>
            <begin position="27"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00040773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAG5089349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="110" mass="12465" checksum="01760D8489BB1950" modified="2022-05-25" version="1">MIKQISIVIVLSACLITNVRASVYTRAVVESCSGCSLNRLADVKKFIFEDVPEYGNVEFKHITGAKPELVLYDNDDEVERLALSKLTRDECNELLQSKGFKREKTPRDEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MR03</accession>
    <name>A0A8J2MR03_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Similar to Dennd1b: DENN domain-containing protein 1B (Mus musculus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HICCMSTLAB_LOCUS8238</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle</location>
            <location evidence="1">Clathrin-coated vesicle</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5096495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MR03"/>
    <dbReference type="OrthoDB" id="206724at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030136">
        <property type="term" value="C:clathrin-coated vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901981">
        <property type="term" value="F:phosphatidylinositol phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032456">
        <property type="term" value="P:endocytic recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.200:FF:000003">
        <property type="entry name" value="DENN domain containing 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11500:FF:000001">
        <property type="entry name" value="Putative DENN domain-containing protein 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11500">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001194">
        <property type="entry name" value="cDENN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005112">
        <property type="entry name" value="dDENN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043153">
        <property type="entry name" value="DENN_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040032">
        <property type="entry name" value="DENND1A/B/C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037516">
        <property type="entry name" value="Tripartite_DENN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005113">
        <property type="entry name" value="uDENN_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13196">
        <property type="entry name" value="DENN DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13196:SF14">
        <property type="entry name" value="UDENN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03455">
        <property type="entry name" value="dDENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02141">
        <property type="entry name" value="DENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03456">
        <property type="entry name" value="uDENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00801">
        <property type="entry name" value="dDENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00799">
        <property type="entry name" value="DENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00800">
        <property type="entry name" value="uDENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50211">
        <property type="entry name" value="DENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="2" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDENN" evidence="5">
        <location>
            <begin position="24"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="467"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="515"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="583"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="469"/>
            <end position="486"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAG5096495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="878" mass="99662" checksum="7475882517A536C0" modified="2022-05-25" version="1">MGSRLRRSIIDCYYRFSRQNVKHLFECFCEVAAPVGEKSAWILQRYPESFEDNEILKSVPKFSYPCEFEKTTVQHFSFVLTSIDSKWTFGFCRHDPKTETALVILSSLPWHEMFYKLLNHIASLTTSSNSGDLWKFLGDVYASNIPMPGTSVTIALPDPNITFCCQSPRQFELPSIPENRNLTEYYSAVDSHNMIMIFASMLYERRIIFTSKRLSRLSACVQACNALIYPMIWQHIYIPVLPVALIDYLLAPMPFLIGVPTSILERVPRNDLGDVVILDADNNTIESPFQDLESLPQDVLNNLRKALRNRPALLGDGVSRAFLRALVQLTAGYREALTLQQGERITFDQNAFVESRPYSMQPFLRKMLELQIFQQFIEERLHMLNSGLGFSDEFEMEACNYSDKSTSKIIQQYREWTTTMKKEGSAFFRSVKDKANPAVKSAVKSVKDKGKNMKTVYKGLKWKNRSRGNENSIRFHQPRSAPSSPTSDRKLNIFGSGFKSPSGFTATTSYRKELRLRNSNIPDTRKQYSPLNPSSPEESDSLPERLNIDLMNELQDVIFPSTPTVDRTLKPVRSLDSLRSAWTGRLRHGSPPSVPSNETLPNKNFQSVSLSLKSPSNIVSKVERTEDSYDNQIKKFNNQNPTIFFTKQKLSQTVATGSIDKKNNDLIKLTNPFINFDERLSQSKGLDLDNPFANGMIGKEYDPFDTSQIHTLLNSSFSDPIMHNPLKKNDSLSNNELSSCSAHLKETGAVPDLIRLDSTNSDEDIDPLLSKSFVNTNQMSQSLHIPTSSEGLSNPLYPYFLPRHNNTDSNDGVEKNSKDELGDLDLLQEYGLDFHKFNLTNGTSSTRISEATNNFDNVFGLSFPTSTAKSQNHWTKFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MR93</accession>
    <name>A0A8J2MR93_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">F-box/LRR-repeat protein 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">F-box and leucine-rich repeat protein 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">HICCMSTLAB_LOCUS10981</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subunit">
        <text evidence="14">Part of the SCF (SKP1-CUL1-F-box) E3 ubiquitin-protein ligase complex SCF(FBXL2) composed of CUL1, SKP1, RBX1 and FBXL2. Interacts with calmodulin; may antagonize substrate ubiquitination by SCF(FBXL2). May interact with PIK3R1. Interacts with PTPN13.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5102370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MR93"/>
    <dbReference type="OrthoDB" id="550575at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990756">
        <property type="term" value="F:ubiquitin-like ligase-substrate adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031347">
        <property type="term" value="P:regulation of defense response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031146">
        <property type="term" value="P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd22115">
        <property type="entry name" value="F-box_FBXL2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000042">
        <property type="entry name" value="F-box/LRR-repeat protein 20 isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000060">
        <property type="entry name" value="F-box/LRR-repeat protein 20 isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1280.50:FF:000013">
        <property type="entry name" value="F-box/LRR-repeat protein 20 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050648">
        <property type="entry name" value="F-box_LRR-repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057207">
        <property type="entry name" value="FBXL15_LRR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006553">
        <property type="entry name" value="Leu-rich_rpt_Cys-con_subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13382:SF69">
        <property type="entry name" value="FI18408P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13382">
        <property type="entry name" value="MITOCHONDRIAL ATP SYNTHASE COUPLING FACTOR B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25372">
        <property type="entry name" value="DUF7885"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00367">
        <property type="entry name" value="LRR_CC"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0106">Calcium</keyword>
    <keyword evidence="10" id="KW-0112">Calmodulin-binding</keyword>
    <keyword evidence="3" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="5" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="12" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-0636">Prenylation</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="7" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="F-box" evidence="17">
        <location>
            <begin position="105"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00065449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00070275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00077972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="CAG5102370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="520" mass="59454" checksum="1D25D0757E7B94B4" modified="2022-05-25" version="1">MEQSTTTGNQWSKQQYLPYQHYYHHYHNYYYYYNDHHHRHHHQHDHQHHQRQQQCCDRHHQHHQNQEYLPSSCYMSPSIAHISMSNMKKQSSGVQLTWVFHDDEAQINKKLPKELLLRILSYLDVVSLCRCAQVSKAWNVLALDGSNWQRIDLFDFQRDVEGPVIENISRRCGGFLRQLSLRGCQSIGNNSMKTLAQSCPNIEELNLSQCKKISDVTCAALSSHCSKLQRLNLDSCPEITDLALKDLSDGCRLLTHINLSWCELLTDNGVEALARGCPELRSFLSKGCRQLTDRAIKCLARYCPNLEAINLHECRNITDDAVRELSERCPRLHYVCISNCSNLTDASLLMLAQHCPLLSILECVACTHFTDAGFQALARNCRLLEKMDLEECTLITDATLIHLAMGCPRLEKLSLSHCELITDEGIRQLALSPCAAENLAVLELDNCPLITDASLDHLLQACHNLERIELYDCQLITRSGIRRLRSHLPNIKVHAYFAPMTPPPSAGASRQRYCRCCVIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MSQ8</accession>
    <name>A0A8J2MSQ8_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Similar to Gsc: Homeobox protein goosecoid (Mus musculus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HICCMSTLAB_LOCUS9239</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the paired homeobox family. Bicoid subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5099797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MSQ8"/>
    <dbReference type="OrthoDB" id="6159439at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000223">
        <property type="entry name" value="Goosecoid homeobox 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051440">
        <property type="entry name" value="Goosecoid-like_HB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46643:SF1">
        <property type="entry name" value="HOMEOBOX PROTEIN GOOSECOID-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46643">
        <property type="entry name" value="HOMEOBOX PROTEIN GOOSECOID-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 6 7" id="KW-0371">Homeobox</keyword>
    <keyword evidence="5 6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="9">
        <location>
            <begin position="219"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="6">
        <location>
            <begin position="221"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="67"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="293"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="13"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="67"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="95"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="124"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006503"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAG5099797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="328" mass="37072" checksum="535E19F920ACE5E0" modified="2022-05-25" version="1">MVESSYAGDSPRSRSPMTEPSSPLQDTSGISATNINILNHQRFLYSYSPESVQQKLKTLEQFTQKEHFNRERDRGFLRTSPMSEETRYRQREIITSSSRPSSSSALTSPTSLFTIDSILAPRPTGGNSTSTSSGIGGQNNSEAVDSPPRTLHPLQQQLHHLAFTPADFLAAAYPGLYPSGYVAAMAAAGVSLHSQPAFYHATHPYQMNPNGPGVGPMTKRKRRHRTIFTEEQLEQLEATFDKTHYPDVLLREQLALQVDLKEERIEVWFKNRRAKWRKQKREEQERLRKLQLEQRQRSDDSVNAIRVPGHLSLNGQHEDTDSSDLEVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MT86</accession>
    <name>A0A8J2MT86_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to acr-16: Acetylcholine receptor subunit alpha-type acr-16 (Caenorhabditis elegans)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS7138</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5093812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MT86"/>
    <dbReference type="OrthoDB" id="5975154at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006811">
        <property type="term" value="P:monoatomic ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.390:FF:000058">
        <property type="entry name" value="Nicotinic acetylcholine receptor alpha6, isoform D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.390">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036719">
        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038050">
        <property type="entry name" value="Neuro_actylchol_rec"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006029">
        <property type="entry name" value="Neurotrans-gated_channel_TM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02932">
        <property type="entry name" value="Neur_chan_memb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90112">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane pore"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0675">Receptor</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="127"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel transmembrane" evidence="2">
        <location>
            <begin position="13"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5093812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="153" mass="17541" checksum="C9F0CA125829BEE6" modified="2022-05-25" version="1">MKRPGRKITWKTITNNRKMREMERKNKSSKSLIANVLDMNDDYRLKPTVSSVSSTYTRTSGHDTPRRPTTVEETTIGMPYNGTSCHYSELKTILGELQFITKRMKKADWENEVISDWKFAAMAVDRLCLIVFTLFTLIATIAVLLSAPHIIVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MTP7</accession>
    <name>A0A8J2MTP7_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Apolipoprotein D</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HICCMSTLAB_LOCUS13720</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 7 8">Belongs to the calycin superfamily. Lipocalin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5109084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MTP7"/>
    <dbReference type="OrthoDB" id="565904at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007420">
        <property type="term" value="P:brain development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006869">
        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000302">
        <property type="term" value="P:response to reactive oxygen species"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042246">
        <property type="term" value="P:tissue regeneration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002969">
        <property type="entry name" value="ApolipopD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012674">
        <property type="entry name" value="Calycin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022271">
        <property type="entry name" value="Lipocalin_ApoD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022272">
        <property type="entry name" value="Lipocalin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000566">
        <property type="entry name" value="Lipocln_cytosolic_FA-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10612">
        <property type="entry name" value="APOLIPOPROTEIN D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10612:SF34">
        <property type="entry name" value="APOLIPOPROTEIN D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00061">
        <property type="entry name" value="Lipocalin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036893">
        <property type="entry name" value="Lipocalin_ApoD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01219">
        <property type="entry name" value="APOLIPOPROTD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50814">
        <property type="entry name" value="Lipocalins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00213">
        <property type="entry name" value="LIPOCALIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="6" id="KW-0873">Pyrrolidone carboxylic acid</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035350744" description="Apolipoprotein D" evidence="7">
        <location>
            <begin position="17"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="Lipocalin/cytosolic fatty-acid binding" evidence="9">
        <location>
            <begin position="103"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00019890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR036893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAG5109084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="195" mass="22220" checksum="EE793A7F85397D86" modified="2022-05-25" version="1">MLRLCVIICFLSGVFSQTPGIGKCPQPKVKSNFDLKRYQGDWFELRHSIPNIYELYGKCTKVNYKLDEFGFLISTNEMFSELNRFQQRMIGNATIDTANCVKGSKCGKLKMAFPSAYADKVISPYWVLGTDYSSFATVWSCLEYDSYHFQYVWILGKEEHPATSVVKAAMRILKINGLDDIPMTDTNQNDCPLKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MXP6</accession>
    <name>A0A8J2MXP6_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HICCMSTLAB_LOCUS11795</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5104023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MXP6"/>
    <dbReference type="OrthoDB" id="7686737at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072594">
        <property type="term" value="P:establishment of protein localization to organelle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002000">
        <property type="entry name" value="Lysosome-assoc_membr_glycop"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11506">
        <property type="entry name" value="LYSOSOME-ASSOCIATED MEMBRANE GLYCOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11506:SF2">
        <property type="entry name" value="MACROSIALIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0732">Signal</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035205637" evidence="8">
        <location>
            <begin position="20"/>
            <end position="1045"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="1012"/>
            <end position="1033"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="59"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="587"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="658"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="66"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="223"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="350"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="367"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="413"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="436"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="462"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="493"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="519"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="548"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="663"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="701"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="737"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="752"/>
            <end position="792"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAG5104023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="1045" mass="107074" checksum="3400D89F1C507A2F" modified="2022-05-25" version="1">MWFKRVLIVAVFIFQVTSSEDATPTPPGVIPLEKEFSVSDLSSSASSLASASSSATATAVSNSTDGNSTTTPASNLTDTTGGLMNGTTTADNSTVPANGTIDNSTVSSIDPADSSTTLSDAPDTNVTSLDATSDNTTSPANPTCNKTALPANATNDNSTLTGVGSDGNSTALNSTELALPGGNSTADNSTLASNCTDGTTPGGNSTEDATTLATNLAEGITSPDGNSTENVDGTSPNLPDNSTLDGTTLDKNSTADNSTLVGNSTGGTTPSDNSTDATTMPGGNSTELTPSLNSTDGTMQPGLNSTNGTTPCDNSTDATTMPGGNSTELTPSLNSTDENTTAEEENLADNSTSTTLSTNSTEEQKTPQDNSTATPTPESMTPGLNSTIDPTAITAGEIVEPTSSEDKLKANLTAVSDSTEKAASNSTTEGTTADGKPTEKPSESKVDGTTDSTGSTKEDSTSESLLDTATPADNSTSSADSEKGPTTLLPEITSESPIENTIEDTNSTDEATTASNDLASNATAESTANSTAASSAKTTDKSAEDTTSEPTANVTAPSLTEAKTSPSADSGIDEVTLTADSIVEHKTSKSHATVIPTTPSDHSTAEDTDSTAIEKKTKESIYKAINDRLLNHMSAFKFDFYQTAADKQAALSLSKNETDSLADNSTASNSTDTNNSTLSNNSTAESSTLEADSSTAGPDLSSATAVSNTTADSNSTATSEGSDSSATTGALSSTASPDESSTGASSGDLTGSTKSASDADNSTASNSNADATSAAAATASSNSSSNTTQDESTSFEKSTDLATEMEAHPTTLAANSSPQSSDHSLQYKYVVVDPKTKIPCVLMSAVMNLDVHYEMANHTMANGSMTIPPTAQVEGTCSYTDAMMILKWKNEKLSKSKRDVDSDETGMNSVVFNFVSKDSKAYLDNIEANIYLDNATFPYALKATLKEKSIERLSLFEANISTEYLICDERTDVHTPNITLSMKNVALIAFNTKEDLALRKAHVCGNEVTVNVGAIIGGLTAAIVIICVILYFISKKSKRTSANLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MYI3</accession>
    <name>A0A8J2MYI3_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Mitochondrial (Mus musculus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS11649</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5103717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MYI3"/>
    <dbReference type="OrthoDB" id="10064757at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013584">
        <property type="entry name" value="RAP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00952">
        <property type="entry name" value="RAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RAP" evidence="2">
        <location>
            <begin position="593"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5103717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="663" mass="77313" checksum="B722ECDBE7594FFC" modified="2022-05-25" version="1">MFSRRLRILLSVQEQLSRLRFQSGAITRQVNLKTVCNDQQKTITNSKQIHTLSPALYQSAKPLNSQSQNSQLKYDNEENDSESESEVEDVESSEKSYSVRLTENLYAYTILKNSSKVNTLVPQLIPEEDIPEDVVARILEKNHEDYSPEEVLEHFRLLSFHRGRQKTGLLTADKHKNILQALKKYLHDFSDEELWSLFRYIELWYPMQLTTKQPLLKELEKAMDQECLLRMNIWSVDEWLKICDLWYHLRQSRESNFVLRCMKKLGRKPSKLTAGNYLHYMFLFNISRKPDLNMYELEYRLEKCVNQFTGNELGIIAMGFFKTSTPIRNPQLKLLYAVKPRIPTVSTATLVHTAHAAATVLAYEKEVIDEVLERFLPCIPMARLKDLERMLFSLAIFKYPKESLQYKLIIEELRNPRRTSELKKFPKCLTTSLMHLSYAEIYPLDLIAKVLSPEFLKEAFNNNAFRIGRECMVVDMGLKVEVPEYTGPFLPERVINYLSKRYSSSEIDVGDPTGRIPSFQRFTLEFVQLLKEVVDSKEIIVLQLLPHLQRSEVLMCIDKENKIVPAAPHFQKIDFSSIKYAPKEPADCRWLAFILASHNHLFRGTAEPCGSLEAKIRQLKKIGYYPIVVPHASWYQSVKTLKEKKQYLKELLLQHDVNVQSKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2N0I8</accession>
    <name>A0A8J2N0I8_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="20">Similar to CG31760: Probable G-protein coupled receptor CG31760 (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">HICCMSTLAB_LOCUS13648</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Neuron projection</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="16">Postsynaptic cell membrane</location>
            <topology evidence="16">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G-protein coupled receptor 3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5109012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2N0I8"/>
    <dbReference type="OrthoDB" id="2129233at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045211">
        <property type="term" value="C:postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15293">
        <property type="entry name" value="7tmC_GPR158-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017978">
        <property type="entry name" value="GPCR_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043458">
        <property type="entry name" value="GPR158/179"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054714">
        <property type="entry name" value="GPR158_179_extracellular"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32546">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR 158-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32546:SF16">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR CG31760-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00003">
        <property type="entry name" value="7tm_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22572">
        <property type="entry name" value="GPR158_179_EC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50259">
        <property type="entry name" value="G_PROTEIN_RECEP_F3_4"/>
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        </location>
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        </location>
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        <location>
            <begin position="330"/>
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        </location>
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            <begin position="161"/>
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        <location>
            <begin position="667"/>
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            <begin position="164"/>
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        </location>
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        <location>
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        </location>
    </feature>
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        <location>
            <begin position="679"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004487"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00007242"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
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    </evidence>
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        <source>
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    </evidence>
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    </evidence>
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            <dbReference type="PROSITE" id="PS50259"/>
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    </evidence>
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        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="705" mass="78837" checksum="AD398193876D04BC" modified="2022-05-25" version="1">MAAMMMQNLGSNNHPPGLLDAVARSLLSSVNNAIATRVVVLNASTDIVIAETWLKRTPSSMGEPIKLESDTLRAGYRPHPGLPWFEKPGGSTSQLRSPKFVLSAPIESYMGWWTVPYLSCKTHQWIISYSVYVRQSDARTGTRDFLSVDIDISGLEVNQCDQETSSSADSAPTFTSSSSSSSSTSDGIRQHLDTFGAASPRDNQMESFSGSHKCHNDTTQCEYRGPFSSSSSSSSSSRSAEISVSPIAPGWVKGAYVCRCRDGFYSLDLSSAAERELATFDGVLVEAAWREMQLNKSDLYDKMFRCTRCAVGCITCTGPEPCLATYHWPFRITLLTFSIFCSCGAVLLIFYVYKHRKLKVFKVASPIFLSITLLGCAIMYLEMAAIFPVLDVYSCIATKWTRHLGFCISYTALLMKTWRVSLTYRVKSAHKVKLTDKQLLQWMIPILLVMIIYLSTWTLSAPPDAHVIADSQGLKFYQCNYNWWDHSLAIGEILFLAWGIRVCYNVRNAESLFNEARLISYAIYNIAGVNTTMIAIHLFIFPHAGPDIKYTLGFLRTQLSTTVTVGLVFGPKVLRVLRGHGDQWDSRARARGITASFSLNGIRGLVAEETTDLFQENEELKEEIQKLAAQIEFMKIVHMEMHNRHIKPKMGGSLHRARRMELLRERKAARERERENQETNRQQQSTVDKSEGVTSTSGASSGEHV</sequence>
</entry>
<entry dataset="TrEMBL" created="1999-05-01" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>Q9YID2</accession>
    <accession>S6D364</accession>
    <name>Q9YID2_COTCN</name>
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        <submittedName>
            <fullName evidence="3">Cc_ep1.0_8.2</fullName>
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        <submittedName>
            <fullName evidence="2">Early-expressed protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">ep1</name>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS942</name>
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        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
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    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="1999" name="Insect Mol. Biol." volume="8" first="319" last="327">
            <title>The excision of polydnavirus sequences from the genome of the wasp Cotesia congregata (Braconidae, microgastrinae) is developmentally regulated but not strictly restricted to the ovaries in the adult.</title>
            <authorList>
                <person name="Savary S."/>
                <person name="Drezen J.M."/>
                <person name="Tan F."/>
                <person name="Beckage N.E."/>
                <person name="Periquet G."/>
            </authorList>
            <dbReference type="PubMed" id="10469249"/>
            <dbReference type="DOI" id="10.1046/j.1365-2583.1999.83130.x"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2013" name="Philos. Trans. R. Soc. Lond., B, Biol. Sci." volume="368" first="20130047" last="20130047">
            <title>Functional endogenous viral elements in the genome of the parasitoid wasp Cotesia congregata: insights into the evolutionary dynamics of bracoviruses.</title>
            <authorList>
                <person name="Bezier A."/>
                <person name="Louis F."/>
                <person name="Jancek S."/>
                <person name="Periquet G."/>
                <person name="Theze J."/>
                <person name="Gyapay G."/>
                <person name="Musset K."/>
                <person name="Lesobre J."/>
                <person name="Lenoble P."/>
                <person name="Dupuy C."/>
                <person name="Gundersen-Rindal D."/>
                <person name="Herniou E.A.Drezen.J.M."/>
            </authorList>
            <dbReference type="PubMed" id="23938757"/>
            <dbReference type="DOI" id="10.1098/rstb.2013.0047"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="AF049877">
        <property type="protein sequence ID" value="AAC82354.1"/>
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        <location>
            <begin position="1"/>
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    </evidence>
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    </evidence>
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        <source>
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    </evidence>
    <sequence length="273" mass="30689" checksum="9C63CD95A0648057" modified="1999-05-01" version="1">MFAKLLVFVLAVHMATCATMIKQSDHMATSTPTSTSTTIPTTMTKPTVPSYPSQGVIEILNYPNIIHEGTFIEKRKILNMENSSKLQAKSITIEDSIIPVEGKTLYIIANHVKLYRNAFVGNNYAIRIIAEKINLMSNLFVGDSSTYEALGGTISVHENYYVGDNLSYKVLGSSIIEVLNKFTGNDHHYNLTAVDIQQIRNEYSEDLPIYNRVGFGTGNPNNVTDKTRQYISRESCIFWGNRQIHEVNGSLLCDYDNHFSGENMVFREHGTRC</sequence>
</entry>
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        <citation type="journal article" date="2013" name="Philos. Trans. R. Soc. Lond., B, Biol. Sci." volume="368" first="20130047" last="20130047">
            <title>Functional endogenous viral elements in the genome of the parasitoid wasp Cotesia congregata: insights into the evolutionary dynamics of bracoviruses.</title>
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                <person name="Bezier A."/>
                <person name="Louis F."/>
                <person name="Jancek S."/>
                <person name="Periquet G."/>
                <person name="Theze J."/>
                <person name="Gyapay G."/>
                <person name="Musset K."/>
                <person name="Lesobre J."/>
                <person name="Lenoble P."/>
                <person name="Dupuy C."/>
                <person name="Gundersen-Rindal D."/>
                <person name="Herniou E.A.Drezen.J.M."/>
            </authorList>
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        </citation>
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    </reference>
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            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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    </dbReference>
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        <location>
            <begin position="93"/>
            <end position="114"/>
        </location>
    </feature>
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        <location>
            <begin position="104"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5092371.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CCQ71114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
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        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2013-10-16" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2013" name="Philos. Trans. R. Soc. Lond., B, Biol. Sci." volume="368" first="20130047" last="20130047">
            <title>Functional endogenous viral elements in the genome of the parasitoid wasp Cotesia congregata: insights into the evolutionary dynamics of bracoviruses.</title>
            <authorList>
                <person name="Bezier A."/>
                <person name="Louis F."/>
                <person name="Jancek S."/>
                <person name="Periquet G."/>
                <person name="Theze J."/>
                <person name="Gyapay G."/>
                <person name="Musset K."/>
                <person name="Lesobre J."/>
                <person name="Lenoble P."/>
                <person name="Dupuy C."/>
                <person name="Gundersen-Rindal D."/>
                <person name="Herniou E.A.Drezen.J.M."/>
            </authorList>
            <dbReference type="PubMed" id="23938757"/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5092416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="HF586473">
        <property type="protein sequence ID" value="CCQ71179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S6D2W8"/>
    <dbReference type="OrthoDB" id="10641344at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5092416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCQ71179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="178" mass="20890" checksum="BA230B1464B8EDA4" modified="2013-10-16" version="1">MMSRWNVYMLAEESWVFSTYCHSKCFDRNPDDLGYLSVRREWYRRCSSDVQPSHHKGTPLYHPASADTSDIKLCELLHMQKPNVPYDEVETGFYNAMSYTTCPDPSCPPKLELGSVGRLQKSLIAVTNVFKILSDFCSYGKLLVLDDYSYARSIYYRACRPKQDYYRRSRSRLNLQMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2E0S4</accession>
    <name>A0A8J2E0S4_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS381</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001114">
        <property type="protein sequence ID" value="CAG5073438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2E0S4"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5073438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="91" mass="10100" checksum="0ECD6986E864AAC7" modified="2022-05-25" version="1">MDEPPDIRRSERIAAKNNNISFVTPHFSTTAFEHSFVELPSEVTKTHSVLTPSKSVPMNSSEIGTRRSAMYINLIIRAQSTESINPSLVAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2E9I9</accession>
    <name>A0A8J2E9I9_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Similar to CG32669: Putative sodium-dependent multivitamin transporter (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HICCMSTLAB_LOCUS866</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001114">
        <property type="protein sequence ID" value="CAG5074094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2E9I9"/>
    <dbReference type="OrthoDB" id="6132759at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006814">
        <property type="term" value="P:sodium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11492">
        <property type="entry name" value="SLC5sbd_NIS-SMVT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1730.10">
        <property type="entry name" value="Sodium/glucose cotransporter"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038377">
        <property type="entry name" value="Na/Glc_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001734">
        <property type="entry name" value="Na/solute_symporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051163">
        <property type="entry name" value="Sodium:Solute_Symporter_SSF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42985:SF40">
        <property type="entry name" value="LD47995P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42985">
        <property type="entry name" value="SODIUM-COUPLED MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00474">
        <property type="entry name" value="SSF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50283">
        <property type="entry name" value="NA_SOLUT_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0915">Sodium</keyword>
    <keyword evidence="10" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="39"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="86"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="120"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="150"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="250"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="302"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="327"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="356"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="422"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU362091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAG5074094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="506" mass="55344" checksum="DA4C5056B628B435" modified="2022-05-25" version="1" fragment="single">EYFSANKSMGPISISICLMVSFMSAITLLGVSAENYTYGAIFVIINFSYLIGTPIVCYGYLPVFYKLQATSTYEYLEKRFGGSARILASSIVWLQMLLYSGIVLYAPALAFKTTTGMEKLTSILSVGLACAFYSSIGGIKAVLITDIFQAFLMFASLIIIIATAASSVGGLDKIWEIAGEGGRLNFNNFSLDPTERHTCWGLIIGGIGLAIYSKYFNCDPVTITTIKKNDMLMPLYIMDMTSSLPGLPGLFVAGIFSAGLSTISAALNALAAISLEDYIKPLYFICTGKEFSPKKSLICSKVLAFILGIFCILLAILAQYLNSILQMSLTIFGVVGGPLVGLFTLGMLFESSTQRGAIFGTTLSLIFLIWISFGGPRPFPQALPMSVEGCNSDLLAKFNGTLNFQNNSVPKKEFFYLYRISYLWYAPIGVVMTIVVGWITSNLLQSLGLDRVKKNLDPDLFFPCIARRIRSRNRNNCGEESSEANLKKYQVKDDVADAKTQESLCT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2EAJ1</accession>
    <name>A0A8J2EAJ1_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similar to PPAF2: Phenoloxidase-activating factor 2 (Holotrichia diomphalia)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS22</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030000129">
        <property type="protein sequence ID" value="CAG5070472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2EAJ1"/>
    <dbReference type="OrthoDB" id="10067343at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5070472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="89" mass="9651" checksum="53D1E796B63505D1" modified="2022-05-25" version="1">MMTAQMLNSTTPTENTVDAMRLLDMKAADSGEAPQGNAPAPLRGTINFVKSVTEGGKNDGKVKNPDEIELDLDSEEETEEIEEEEVPVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2EAL6</accession>
    <name>A0A8J2EAL6_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="6">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HICCMSTLAB_LOCUS507</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="6"/>
    <dbReference type="EMBL" id="CAJNRD030001114">
        <property type="protein sequence ID" value="CAG5073581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2EAL6"/>
    <dbReference type="OrthoDB" id="19653at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43142">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43142:SF1">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0719">Serine esterase</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035339692" description="Carboxylic ester hydrolase" evidence="6">
        <location>
            <begin position="25"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="7">
        <location>
            <begin position="35"/>
            <end position="553"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG5073581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="570" mass="64585" checksum="F0942A2336B6E19A" modified="2022-05-25" version="1">MKSSINFSLFAVVISIVLITVLSSDDSLENLNKDRPIVEVHEGKLRGVQEKNYNGTDYFYAFRGIPYAKPPVGDLRFKEPEPVEPWSDIRDAQFFGNMCAQFHWGLKHLEGSDDCLHLNVYTTDLTPEEPRATMVSLHGGAFFWGTGNDLLYGPDFLIKKNIVLVTVNYRLGIFGFLNLDDEEVPGNQGLKDQILALKWIKNNIAKFGGDPTRITLFGHSAGAASVHFLSFVPAAQELFHRVILQSGLATVPWASPSQPMTYAATRVARNLGCNDTDTKELIKFLQSVDAVKLADIVHKTFNPQKYYTPEKPFVPSIDSKSKNPILLASISDLAKQSIKKPTIVGYNTEEAIFLLAEAEDDDYQYIDMLLIFSNGKKFLQDRGVSSGDVKKYFMGDKKFNRTNAAPIIQLLQAYFQTTYVDEFLEIQTTEVPDIPVYLYKFDYYSKETAMVQKFFKSDLKENFNCLCLSGTAHAEEIPYLFYCKFFLNLGIEQPISFPSGRIVQQRMLTLWTNFAKTGNPNLPKSEVISVDWKPVDNSTEFNCLKISDNLTMIQEPNILRQLEIFARHDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2EBI2</accession>
    <name>A0A8J2EBI2_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS550</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001114">
        <property type="protein sequence ID" value="CAG5073666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2EBI2"/>
    <dbReference type="OrthoDB" id="6509516at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579">
        <property type="entry name" value="F5/8 TYPE C DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579:SF1">
        <property type="entry name" value="F5_8 TYPE C DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="386"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="30"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5073666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="707" mass="81236" checksum="EC8DEF095A269B87" modified="2022-05-25" version="1">MVALKRIENNSKTDIGEESKRSAFSGLSEAESRSYTKGKKENDAANNSGLCDKSLREDDLYKLKNTIMFEPSNLSVWQVLTMIMAIVVRFNLSDEIQQAIISLMKLAAGPQFKCLDTSKYLINKFFNPVSNAAQYVFYCPTCNNLLTNPLPITKNIKSEVTCDKCKKKYETSKKEGNFFVTVDLEPQLQNYLSTEYVRKQIQDKIENRSNTNAEHSISDVCDSDRYKADEFIQSKNDSDNVVLTLNVNLDGAPLFKSGKNSFWPIQCIINEIPQIMRHNFMLLAGLWYTSCEPKPEFMNLYLKSFITQIQKLTVTGLKVLVENGRVITYFVKIFSFPVDSVARPVLQNRLQFNGFYGCSWCYQRGQTSSRSMKYPLSSDTPRLRDHESYVKDVEKHKNDIKKLRKTKKNEKYTVFGIKGSSVLSSLSDFDCVWGFPHDYMHGVLLGVTRQLWNKWSKEFLSVDQRKLINARLTAIQPPNEIHRTPQILLKRKSWKATEWRSWLLFYSVPVLSGILRQDLLDSYKLLVKSIFKLLSVNLTENELLQCEMDLLKFVYDCQNLYGISFITFNVHSLLHIVDSVRKNGPSWATSTYAFENNIYNLKLQVSGPNGVLGQMAIRTLRSNNFQKVLATESNETCRQFSEGILNKKRPNVSKAVESDNGALLMDHVNEGQLENSAYSIVVVYFKKRCITVKYINKQEKLTTHLLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2EBM2</accession>
    <name>A0A8J2EBM2_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Similar to aralar1: Calcium-binding mitochondrial carrier protein Aralar1 (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">HICCMSTLAB_LOCUS1136</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subunit">
        <text evidence="12">Homodimer (via N-terminus).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001116">
        <property type="protein sequence ID" value="CAG5074925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2EBM2"/>
    <dbReference type="OrthoDB" id="2161at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015183">
        <property type="term" value="F:L-aspartate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005313">
        <property type="term" value="F:L-glutamate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043490">
        <property type="term" value="P:malate-aspartate shuttle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000416">
        <property type="entry name" value="Aralar1, isoform F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000396">
        <property type="entry name" value="Calcium-binding mitochondrial carrier protein Aralar1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000004">
        <property type="entry name" value="Calcium-binding mitochondrial carrier protein Aralar1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051028">
        <property type="entry name" value="Mito_Solute_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45678:SF9">
        <property type="entry name" value="CALCIUM-BINDING MITOCHONDRIAL CARRIER PROTEIN ARALAR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45678">
        <property type="entry name" value="MITOCHONDRIAL 2-OXODICARBOXYLATE CARRIER 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00036">
        <property type="entry name" value="EF-hand_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13202">
        <property type="entry name" value="EF-hand_5"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0106">Calcium</keyword>
    <keyword evidence="11 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="EF-hand" evidence="14">
        <location>
            <begin position="102"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="14">
        <location>
            <begin position="173"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="13">
        <location>
            <begin position="341"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="13">
        <location>
            <begin position="440"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="13">
        <location>
            <begin position="532"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="15">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00038674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CAG5074925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="688" mass="76755" checksum="5568A64183FB8753" modified="2022-05-25" version="1" fragment="single">GAGYLKRANSERLHEIFNQGAGYLKRANSERLHEIFNQYATQEKNGERYMTPSDFVRSYLGLYTDSDYNPDSVALLAGIVDTSKDGLISFAEFQAFEGLLCVPDALYKTAFQLFDTNGNGMVAFDEFAEVMKKTELHKKMPFNMDSSFIKLYFGKDRKRLITYGEFSQFLHDFHEEYALEAFKKFDKDMQGFISITDFQEIMMSIKSHLLTKEVKENLIAAATTGHGGRKVSFPYFMAFNSLLNNMELVKRIYLNATNGHRYQEVTKEEFLYSAQMMSQITPLEVDILFHLCDLLRQNTKIIYNDLVAITPEQYFKHITRRLAEIKAVSSPADRGIGTQILESGYRFVLGSIGGAVGATAVYPIDLVKTRMQNQRTGSFIGELMYRNSFDCCKKVIRHEGFFGLYRGLVPQLMGVAPEKAIKLTVNDFVRDKFMDKNGNIELLGEIISGACAGGSQVIFTNPLEIVKIRLQVAGEIAGAQKVRAWAVVKELGLFGLYKGARACLLRDVPFSAIYFPMYAHTKAKLADEGGYNTPLSLLCAGAIAGVPAAALVTPADVIKTRLQVVARQGQTTYSGLIDCARKIYHEEGARAFWKGATARVFRSSPQFGVTLFTYELLQRLFVVDFGGSRPTGSDLKVPSTGIADDLKSKNSDHLGGYEVAVPIFSGIETKFGLSLPRFQAAPRPIPNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2EBY2</accession>
    <name>A0A8J2EBY2_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Similar to mylk3: Myosin light chain kinase 3 (Danio rerio)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HICCMSTLAB_LOCUS1203</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001116">
        <property type="protein sequence ID" value="CAG5074996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2EBY2"/>
    <dbReference type="OrthoDB" id="10260894at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043065">
        <property type="term" value="P:positive regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14103">
        <property type="entry name" value="STKc_MLCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000315">
        <property type="entry name" value="Calcium-dependent protein kinase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000594">
        <property type="entry name" value="Myosin light chain kinase isoform-III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24342:SF20">
        <property type="entry name" value="MYOSIN LIGHT CHAIN KINASE, SMOOTH MUSCLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24342">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="33"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="290"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="351"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="294"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="358"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="62"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAG5074996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="936" mass="106248" checksum="30134B4749108826" modified="2022-05-25" version="1">MIHVDESDPVGEIEPAFPYKDVTVRRDEFNSNYELQEELGRGKFGTVYLCKDKKNGLKLAVKIVNTTKKEDRRSVEREVEIMRRLQHPRLIQLYDAIDNTKQFYVVLELIEGGELFERVIDDDFVLTERSCAVFMRQICEGIEFVHSQNILHLDMKPENILCLTKEGNRIKIIDFGLARQFDPRKKLQVLFGTPEFVAPEVVNFDQIGYGTDMWSIGVICYVLLSGLSPFMGDTDVETMANVTIAKYDFDHEAFNNISEDAKDFIRRLLVKDKEKRISAHVCRFHPWLAPKSNSKTKKPSPLKKKKKIKKVAPPVATPAPPVVKNKSELDVTKDNLKQFVERWRDHPNSPYLFEDNGTVEREGDRSMSLKGQSPSPPESICSLTSESAFDDRLFLNVPNLAFERRASEGQGQEYRDPASQIKIAEEIIKLSEHLRLLANREGNNKMAGDMANMDNMAYGEGKIKKAEGEIQKNMAENINMANMAQNMANMGDMANMDNITHNMATREDISLLKGNKFKKNTSDMANKVNMAHMAPNMANMANMAPNVANMAHMANIPNTAQNMAIGHDKSLLKEDKIKKNILNMGNMADMARNMANMSDMATNMADQDTNQIKRTNMSNMENMGKNMANMANMGDMATNISDQNTSKVKRNNISNMETMGTNMADMAQNMANMGDMATNISDQNTSKVKRNNISNMETMGTNMADMAQNMANMAYGQDGSQIKATEMESKVSSIKSSRVSINTSESETNEINEKLNAITRDRKLNGTKFNPHKSFQETVFNRFDREDVDIDLTPPWRKARAKHRFGETCRDVPRITNLQNMHKTMNLDEPNSAKNLLLKLLDEWDQEKPRGAALPRKSISVDWNDESIGRRSINSLARKRPSAAQLQEHRWLAKALENPISKVRLKRYVIKKRWVKAVNTILALQRMGAHINFDLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2ECG0</accession>
    <name>A0A8J2ECG0_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Similar to ALKBH8: Alkylated DNA repair protein alkB homolog 8 (Bos taurus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HICCMSTLAB_LOCUS1442</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001116">
        <property type="protein sequence ID" value="CAG5075288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2ECG0"/>
    <dbReference type="OrthoDB" id="271595at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106335">
        <property type="term" value="F:tRNA (5-carboxymethyluridine(34)-5-O)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002098">
        <property type="term" value="P:tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.590">
        <property type="entry name" value="Alpha-ketoglutarate-dependent dioxygenase AlkB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027450">
        <property type="entry name" value="AlkB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037151">
        <property type="entry name" value="AlkB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051422">
        <property type="entry name" value="AlkB_tRNA_MeTrf/Diox"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13069">
        <property type="entry name" value="ALKYLATED DNA REPAIR PROTEIN ALKB HOMOLOG 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13069:SF21">
        <property type="entry name" value="ALKYLATED DNA REPAIR PROTEIN ALKB HOMOLOG 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13532">
        <property type="entry name" value="2OG-FeII_Oxy_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="6">
        <location>
            <begin position="209"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAG5075288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="588" mass="67911" checksum="7EB6620765915854" modified="2022-05-25" version="1">MEKNTSKSRKCNLKQRKASERLARDLNIISCENPTEFIAICNAGLVTGLKHESLELVINKISTNNSNYKIVMPRGKSYCFIKFEDSSATKNFYDKLNGEFEENLKTTLYLIFCESIPDDNEPVGDQLPGGLRLIEEFISREQEDRLLQLVDWDEHELNSELKHRKVKHFGYEFCYKTNRVDPNSPIEPIPADLEFLYGLFEEHGCGRYKYDQITINRYLPGQGIPPHIDTHSPFEDTILSLSCGSACVMDFKHEDKKIQVYLPARSLLIMSGESRYTWTHGVCPRHHDVVEQKQGDKVTTTTLERGTRISFTFRKIRTGDCPCNYNDCCDSKKSKREIDQSKAPLLESSYVHQVYDEISSHFDETRHKQWPNVAKFIDSIDPGSILLDVGCGNGKYLTPKTGLLKIGCDRSNGLLNICRSKSYQVFQSDCLKLPFRSNSCDAAISIAVIHHLSTADRRRDAFLELIRILRPFGRCLIYVWAKEQRRNKQDSAYLKLNPGKIKEHKNVQLFEDLELPVHDNRTNFSHNDVMVPWKTKSGNEFLRYYHVFDETEFRSLCLRLQEVSVVDIYYDQGNWCCILEKKSSLVLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2ECT3</accession>
    <name>A0A8J2ECT3_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Similar to FAAH2: Fatty-acid amide hydrolase 2 (Homo sapiens)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HICCMSTLAB_LOCUS1755</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the amidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001116">
        <property type="protein sequence ID" value="CAG5075601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2ECT3"/>
    <dbReference type="OrthoDB" id="6428749at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020556">
        <property type="entry name" value="Amidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052739">
        <property type="entry name" value="FAAH2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43372">
        <property type="entry name" value="FATTY-ACID AMIDE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43372:SF1">
        <property type="entry name" value="LD38433P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001221">
        <property type="entry name" value="Amidase_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00571">
        <property type="entry name" value="AMIDASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="21"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="domain" description="Amidase" evidence="4">
        <location>
            <begin position="85"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="2">
        <location>
            <position position="145"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="2">
        <location>
            <position position="220"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-ester intermediate" evidence="2">
        <location>
            <position position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR001221-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAG5075601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="534" mass="59108" checksum="687E94C0E1DB3FEE" modified="2022-05-25" version="1">MCTSILKEDATNTTPKKLKKLLVSFLSCLIVQFHCLLDSIVDFIFGCYYHGKDKKVPPISDKLLLESAVDLADKIRKKEISSELVVTTFIKRCKEVNSLLNVIVDERYEQAIEEAKNVDKILASDIDIEKLKLEKPFFGVPFTTKESNEVQGLLHSVGMMARKGYLSTEDATVVGYVKNAGAIVVAKTNIPELNLWVESRNMIYGQTNNPYNTTRTVGGSSGGDAAITAACGVPFALGSDIGGSIRMPAFFNGVFGLKPSAKATPLKGIGLRSVDFTDSMAEAGPICKHAKDLLPLLKILTKNTDLIKKLDTPVDVKQLKIFYQESLGDLRVSKLTENMRTAFNKAVTHFKDLTGSAQKIKLPGSEYSFRLWRYWMSQEQADFKSDIMNRKSRTSATAEIVNLVTNKSNLTLAAILKLIDEDFFPKDSKAWAESVTNSMKEYLLDKLGEDGVLLFPSSPFAASYHYSYFFRPYNFSYWALFNVLKLPTCQIPLGLGDDGLPVGVQVVAAPYNDHLCIAVAQELEKSFGGWVSPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2ED23</accession>
    <name>A0A8J2ED23_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HTH CENPB-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HICCMSTLAB_LOCUS1891</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001116">
        <property type="protein sequence ID" value="CAG5075846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2ED23"/>
    <dbReference type="OrthoDB" id="7697906at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050863">
        <property type="entry name" value="CenT-Element_Derived"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004875">
        <property type="entry name" value="DDE_SF_endonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006600">
        <property type="entry name" value="HTH_CenpB_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303:SF74">
        <property type="entry name" value="POGO TRANSPOSABLE ELEMENT WITH KRAB DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303">
        <property type="entry name" value="TRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03184">
        <property type="entry name" value="DDE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51253">
        <property type="entry name" value="HTH_CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH CENPB-type" evidence="3">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="589"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="606"/>
            <end position="616"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG5075846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="616" mass="70415" checksum="A64CCEC74B139E66" modified="2022-05-25" version="1">MGFPINREFLIHSVKQLVKAEGMKNPFKDNVPGRKWFEGFLKRHPRVGQKKAEYLCKARAVVTESGIRSWFFHVAEELGENIEILKDPRRVFDMDETAVHLAPKGGLVLAERGKSVYDVAGNEKENVTTLFNVNAAGEFAPPLTIFKYERLPKICVESAPKDWGIGKSENGWMTSESFYEYFTNVFYPFLQKSEIKFPVIVFLDGHVSHMSIHLSKFCKEKQIILCCFPPHATHILQPLDVSFFFPLKQRWKNLIRNWRIENNGADVEKHNVPAFLSKLINEENFVNVIKSGFKACGICPFDADAVDYTKCVEIKESQNAQNISNEPESQKSAQVLSHRQFIESKIDADVLKRFKHAKAAGIAWEADDKYELLYELWVKAIEDDKNVDNDQQSPSCILLASEDLNPSITNDDNVIEFEFLEFSELNFDEVEEPLQSFISHTPNQNPDLGVPLSPEPSILSNINTDSNTIRAVLPSSNNAIQSSPVIIKVIDPNPVSTLSAENVSNSNTITMCRKSLDEVINQIVMWPKKQPSKRKRAVKHLPSVITSNKWIEVMEAKENEKNEKEEERKLKKIEREERIERNKKIKQEKLEEQAKKKSAKQLAAKKPVKSRKMSNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2EDS1</accession>
    <name>A0A8J2EDS1_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similar to Myosin regulatory light chain 2 (Bombyx mori)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS2202</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001117">
        <property type="protein sequence ID" value="CAG5076493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2EDS1"/>
    <dbReference type="OrthoDB" id="429467at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5076493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="80" mass="9084" checksum="F73D6A0415A7F086" modified="2022-05-25" version="1">MLQQDRMRTQLLSRPSAPLTPMERSMETGELRHALLTFGDKFTAKEVNDAFDNMYIDEKGMIDTQSLIAMLTGTGEEDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2EFC2</accession>
    <name>A0A8J2EFC2_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Similar to Arl13b: ADP-ribosylation factor-like protein 13B (Mus musculus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HICCMSTLAB_LOCUS402</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001114">
        <property type="protein sequence ID" value="CAG5073459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2EFC2"/>
    <dbReference type="OrthoDB" id="14717at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060170">
        <property type="term" value="C:ciliary membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097730">
        <property type="term" value="C:non-motile cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051649">
        <property type="term" value="P:establishment of localization in cell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905515">
        <property type="term" value="P:non-motile cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097500">
        <property type="term" value="P:receptor localization to non-motile cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048731">
        <property type="term" value="P:system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051995">
        <property type="entry name" value="Ciliary_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46090">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 13B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46090:SF2">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 13B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00328">
        <property type="entry name" value="SAR1GTPBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00178">
        <property type="entry name" value="SAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="54"/>
            <end position="61"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="61"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="78"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="156"/>
            <end position="159"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAG5073459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="378" mass="42615" checksum="BB5EE98DA290EE3B" modified="2022-05-25" version="1">MVSEELSIILDGDYLCLKLFSTLLPIMGNCLRIIINKIRKKRIIRKNVVLLMAGLDDSGKTSVLNFISNDLDDNVMTTMGFRVVALKHKFYSIKVYDVGGAPQIRSIWKKYYGDIHGIIYVVDASNLSRLNENKLVFAELISHEHIAGKPILLLANKQDISSAIDELDLVENLDIEHAANSMRCPTRVETCSCIITQEYYKQNTMGIVNGFKWLLDTISKNYVELNNRIKASQSVIVPISNHVQKRPSISSITPSHASIRSNPFKPISELVNSSSEKNLLNKNGRVNSRNGFKAKNFLVKNKTAPTLEDDTNNTVNDIEYFHNEIEDSVAFLPLDPINLKSQNFNKTFIPQMRPFTAPATSQRPDVFVMPNLPGQVFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2EH84</accession>
    <name>A0A8J2EH84_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">THAP-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">HICCMSTLAB_LOCUS1611</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the THAP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001116">
        <property type="protein sequence ID" value="CAG5075457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2EH84"/>
    <dbReference type="OrthoDB" id="7675873at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.210.20">
        <property type="entry name" value="THAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026516">
        <property type="entry name" value="THAP1/10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006612">
        <property type="entry name" value="THAP_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038441">
        <property type="entry name" value="THAP_Znf_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46600">
        <property type="entry name" value="THAP DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46600:SF1">
        <property type="entry name" value="THAP DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05485">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00980">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50950">
        <property type="entry name" value="ZF_THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8 12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="THAP-type" evidence="13">
        <location>
            <begin position="1"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CAG5075457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="357" mass="41146" checksum="AA38878118FD5B28" modified="2022-05-25" version="1">MGKLCYVKSCPSGRKLKSKGIDTSQPLSFFQPTTPAKLKKWNMALGTTMKKTDYICHLHFKEKDIKMYETFNIKGEIIILPTGKKTLREEALPTIEHQFISVLAHELQTSVVNKSQNVHSNPNQSEKHQDQHEQQELLLDQRVANNLIRVIQQTEHDLDIPQLNQETHDDVQNDKESDVNSLSAEKFLENIKSSPLPQSWMYFEKVKGLEFVQINPTTMQISNRLQVNKDLSITVIFSTNEELNINDNISSFNSIYDYLKSVERWPICVGTQIDNNKFSKVCKGVLVGDDSYKRNQANPRCKSCRILRHRLQKYNSTSTILEITLRVTLEILDMLKNECECKYLMIATLLQDPLEIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2EJM6</accession>
    <name>A0A8J2EJM6_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Gustatory receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HICCMSTLAB_LOCUS1391</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Cell membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the insect chemoreceptor superfamily. Gustatory receptor (GR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001116">
        <property type="protein sequence ID" value="CAG5075237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2EJM6"/>
    <dbReference type="OrthoDB" id="6366728at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050909">
        <property type="term" value="P:sensory perception of taste"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013604">
        <property type="entry name" value="7TM_chemorcpt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08395">
        <property type="entry name" value="7tm_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 7" id="KW-0675">Receptor</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="54"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="93"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="148"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="172"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="265"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="300"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAG5075237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="372" mass="42395" checksum="5E488857EBE0C978" modified="2022-05-25" version="1" fragment="single">MYNNNRKSLLGSYKIIQHVSSKIIGLAPWTLKVSSIFSDRQQIPNRNITYSSSWVGTVYNIILFLGIASFGIYRMIVNAMSQRFSNSLLSMTIYQLLFVTLINASFIPLIYIIRQKSIMKAINNLKIVDFLLSQCADYTLESDYTNDVIYAINMLMNFGLITLDLFNSLVMSVLFESIPSIISSGVMIQYAIQLNKMNRRFSSINSAFSKLGNHNLKSDINYVPSETQVVQSRALILHAIDITKKAYIELCEICEMITDFYGIPILIAIFSFSVRALFTVYISILSILQIQFSTIRWYLLAIRIIFAIFLFTTLTCSVTTIAKQNKRLALIISHQTDQPEIDEKVEKNLLKFASDLRHLKVEVTACNIIPLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2EKZ2</accession>
    <name>A0A8J2EKZ2_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">B-related factor 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">HICCMSTLAB_LOCUS2286</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TFIIB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001117">
        <property type="protein sequence ID" value="CAG5076811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2EKZ2"/>
    <dbReference type="OrthoDB" id="511529at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000126">
        <property type="term" value="C:transcription factor TFIIIB complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097550">
        <property type="term" value="C:transcription preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000995">
        <property type="term" value="F:RNA polymerase III general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001006">
        <property type="term" value="F:RNA polymerase III type 3 promoter sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017025">
        <property type="term" value="F:TBP-class protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070897">
        <property type="term" value="P:transcription preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20553">
        <property type="entry name" value="CYCLIN_TFIIIB90_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20554">
        <property type="entry name" value="CYCLIN_TFIIIB90_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000002">
        <property type="entry name" value="Transcription factor IIIB 90 kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000007">
        <property type="entry name" value="Transcription factor IIIB 90 kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.650">
        <property type="entry name" value="Single helix bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011665">
        <property type="entry name" value="BRF1_TBP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000812">
        <property type="entry name" value="TFIIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013150">
        <property type="entry name" value="TFIIB_cyclin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013137">
        <property type="entry name" value="Znf_TFIIB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11618:SF4">
        <property type="entry name" value="TRANSCRIPTION FACTOR IIIB 90 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11618">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07741">
        <property type="entry name" value="BRF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00382">
        <property type="entry name" value="TFIIB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08271">
        <property type="entry name" value="Zn_Ribbon_TF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00685">
        <property type="entry name" value="TIFACTORIIB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57783">
        <property type="entry name" value="Zinc beta-ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51134">
        <property type="entry name" value="ZF_TFIIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0010">Activator</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="TFIIB-type" evidence="13">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="473"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="473"/>
            <end position="485"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CAG5076811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="575" mass="65174" checksum="C2723846A0CF8545" modified="2022-05-25" version="1">MPPKCPKCGCTELDTDPSRGDTVCTNCGLVTEDQMLVNEVEFTQTASGQSEAVGQFLGTDMRAPRVGQLHGQSSRELTVYRARKDIAHLCKQLSMSGHQVELATNFYKQVLHRNLTRGRKQILTYAGCIYLTCRIEKTPHLLIDISDITQIDVYELGRTYLHFVKALYLENSVDGAISIDSEDGGNECIKAVDPCLYVMRFAEKLEFGTEKMKVAKTALRLVARMKKDNIHTGRRPSGICGAALLIAARMHDFNRTVGDIIKVVKIHESTLRKRLLEFGETSASALTLDDFESIDFAQEEDPPAFKAARKAEENLREADFMDIGGEFTDLQKEIDKADWFYLIKIKLYLSEQQQRSKKRSLAAMLGADYEEDAEVDRFIESTTREIAENFVEDRGLGPDVSSMGLPNNFFDRRVVKEGSRFEKYNNESGEIDLEGLDDEELDEYILKDADVVKKTELWTVCNADYLELQRKKEEQRLKDEEEGKPPPRKRKAPKKKELANSAGEALENLIKEKKLSKKLNYDVIKQLKEETSIGFGEKKSIGNNYDSAGFVCKCSRLRANEFVVIKLVESERIKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2GZY1</accession>
    <name>A0A8J2GZY1_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Defensin3_Cc</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HICCMSTLAB_LOCUS1263</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001116">
        <property type="protein sequence ID" value="CAG5075100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2GZY1"/>
    <dbReference type="OrthoDB" id="8109893at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019871">
        <property type="term" value="F:sodium channel inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045087">
        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00107">
        <property type="entry name" value="Knot1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.10">
        <property type="entry name" value="Knottin, scorpion toxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001542">
        <property type="entry name" value="Defensin_invertebrate/fungal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003614">
        <property type="entry name" value="Knottins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036574">
        <property type="entry name" value="Scorpion_toxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002061">
        <property type="entry name" value="Scorpion_toxinL/defensin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00537">
        <property type="entry name" value="Toxin_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57095">
        <property type="entry name" value="Scorpion toxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51378">
        <property type="entry name" value="INVERT_DEFENSINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0929">Antimicrobial</keyword>
    <keyword evidence="5" id="KW-0211">Defensin</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0391">Immunity</keyword>
    <keyword evidence="3" id="KW-0399">Innate immunity</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035245987" evidence="7">
        <location>
            <begin position="30"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="domain" description="Invertebrate defensins family profile" evidence="8">
        <location>
            <begin position="33"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAG5075100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="73" mass="8041" checksum="97CF75CA9B1BD22B" modified="2022-05-25" version="1">MAKNYRSMLLLVCLSFLVIVSSPQNGAQADKLIGSCVWGATNYTSNCNAECKRRGFKGGHCGSFWNVNCWCET</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H049</accession>
    <name>A0A8J2H049_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Mutator-like transposase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HICCMSTLAB_LOCUS1534</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001116">
        <property type="protein sequence ID" value="CAG5075380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H049"/>
    <dbReference type="OrthoDB" id="6095482at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008296">
        <property type="term" value="F:3'-5'-DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006308">
        <property type="term" value="P:DNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049012">
        <property type="entry name" value="Mutator_transp_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040393">
        <property type="entry name" value="TREX1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13058:SF22">
        <property type="entry name" value="EXODEOXYRIBONUCLEASE III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13058">
        <property type="entry name" value="THREE PRIME REPAIR EXONUCLEASE 1, 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20700">
        <property type="entry name" value="Mutator"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mutator-like transposase" evidence="8">
        <location>
            <begin position="58"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="Mutator-like transposase" evidence="8">
        <location>
            <begin position="238"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="25"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="221"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="35"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="228"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAG5075380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="867" mass="97811" checksum="12DD6600E72998AE" modified="2022-05-25" version="1">MSKPERQYRWKGKIVSKKIFLQRSKQSELARQLPQKRENSEEPVDDKKDEKNPVLLDGYRIVDLKYLAQQLWCTTCKETLSLEYAESERRIGLAFVLLVRCHKCLLINEVYTGKQKPSLDKRSFRFDINCKSVIGTLHCGSGWTHLKKLLACMDIPSFGFKTFKQYEKEVGLAAEDVAKESFREAAKLEREQTIQQSEALESQLPKEFQSNFIIHRRLSNGDLPPSKPLTSANVQDSSTSEELNTVEIESGASWDDVVRVMVSYDMGWSTRATGRQYDSKNGFGAIIGGLTGLVLDFSTCNRICATCNRGGPTSNHENCRLNFYGSAKAMEPHVAKKLVVDSEILRAENIEVGVLVGDDDCSTIAACRAAANHPIIKQSDVNHTIQKSHKELTKDRIVYLHRCFTYALSQNKGNCSGLAAAIRCIPYHAFNDHTQCGTWCGYNGDKENYVHKVIPGGFQDPILFQELKKIFDKLADNAQKFSNGASSNANESLNAMMASKAPKSRCYSRTASADYRFACAIGQKNVGEGYVKKIAQKINLTSSNHLTRHISSRERILSQRRALIKTHAYKKRRMQLKKFRSMLRHRKENQEGVTYQSNCSLFTEPAVLEEEIDDNDNYLNSEEDTCEYLIILLDLETSGFEADCDILQIAAQCGKKIFATYIDPVRQISQKASEAHGLTNCSGKLFYYGKQVESVSLRLALSNLYEWLKSLGKKCCIATHNLAFDGPRLFRAIDKNKLTSDYSEVVYEFVDTLKKIREVTGKKPKKLEIKSSDLINLATPFLEQTKAWELAVATKKNIDTLSSLEGALSLSIRQKLAKAGITMDILKSKIDPFNAKSLELFLVKKIETKELQPLQKATIKKIVDCFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H0J3</accession>
    <name>A0A8J2H0J3_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Glutathione peroxidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HICCMSTLAB_LOCUS2204</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the glutathione peroxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001117">
        <property type="protein sequence ID" value="CAG5076500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H0J3"/>
    <dbReference type="OrthoDB" id="446890at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00340">
        <property type="entry name" value="GSH_Peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000025">
        <property type="entry name" value="Glutathione peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000889">
        <property type="entry name" value="Glutathione_peroxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029759">
        <property type="entry name" value="GPX_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029760">
        <property type="entry name" value="GPX_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11592">
        <property type="entry name" value="GLUTATHIONE PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11592:SF134">
        <property type="entry name" value="PHOSPHOLIPID HYDROPEROXIDE GLUTATHIONE PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00255">
        <property type="entry name" value="GSHPx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000303">
        <property type="entry name" value="Glutathion_perox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01011">
        <property type="entry name" value="GLUTPROXDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00460">
        <property type="entry name" value="GLUTATHIONE_PEROXID_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00763">
        <property type="entry name" value="GLUTATHIONE_PEROXID_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51355">
        <property type="entry name" value="GLUTATHIONE_PEROXID_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 6 8" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0712">Selenocysteine</keyword>
    <feature type="domain" description="Thioredoxin" evidence="7">
        <location>
            <begin position="28"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000303-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG5076500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="189" mass="21412" checksum="632165881F88CC7A" modified="2022-05-25" version="1">MRFLKCPIIPAGLQQIRNLPVMSGNLDYKSAKSVHDFEAESIKGEKVPLEKYKGHVLLIVNVASKCGLAATNYKELNELYDKYAESRGLRILAFPCNQFNGQEPGGSEEICSFANRQKIKFDFFEKIDVNGETAHPLWKYLKQEKGGLLGSSIKWNFTKFIVDKDGKVVERQGPNIDPSGLVKYLEKYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H2A6</accession>
    <name>A0A8J2H2A6_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Similar to CNGA3: Cyclic nucleotide-gated cation channel alpha-3 (Bos taurus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HICCMSTLAB_LOCUS1250</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001116">
        <property type="protein sequence ID" value="CAG5075078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H2A6"/>
    <dbReference type="OrthoDB" id="421226at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005221">
        <property type="term" value="F:intracellularly cyclic nucleotide-activated monoatomic cation channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044877">
        <property type="term" value="F:protein-containing complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.630:FF:000004">
        <property type="entry name" value="Cyclic nucleotide-gated olfactory channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.10:FF:000058">
        <property type="entry name" value="Uncharacterized protein, isoform D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.630">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050866">
        <property type="entry name" value="CNG_cation_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018488">
        <property type="entry name" value="cNMP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45638">
        <property type="entry name" value="CYCLIC NUCLEOTIDE-GATED CATION CHANNEL SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45638:SF7">
        <property type="entry name" value="CYCLIC NUCLEOTIDE-GATED ION CHANNEL-LIKE, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="cAMP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00888">
        <property type="entry name" value="CNMP_BINDING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00889">
        <property type="entry name" value="CNMP_BINDING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0407">Ion channel</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="21"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="11">
        <location>
            <begin position="141"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="303"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="647"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="730"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="785"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="837"/>
            <end position="871"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="647"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="747"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="785"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="853"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="894"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAG5075078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="894" mass="100905" checksum="31545E0A9F44DA15" modified="2022-05-25" version="1" fragment="single">HEYRALERERLRRARVNANELTLILIFLFTLGRYVFTIVSYLIGVFIFATIVGQVGNVITNRNANRLEFERLLDGAKTYMRHHKVPGGMKRRVLRWYDYSWSRGRIQGGGDINTALGLLPDKLKTELALHVNLSVLKKVTIFQECQPEFLHDLVLKMKAYIFTPGDSICRKGEVAREMFIIADGILEVISETGRVLTTMKAGDFFGEIGILNLDGLNKRTADVRSVGYSELFSLSREDVLAAMKDYPEAQEILQNLGRKRLMEAQRVARLYRAASPGHDSSDNSASKRIVSKLKSDVKSLKTVLRKSRRSRPEEAMELQPLTSKVPPLRRQNKVDVEDRIEAAPGEPPVSPLGAGLPLLSRLRHLKEKHDREERRHLVDMHMPERLAPDSAGQTAKAEELNPMNPNLPLLQRILLLKNKAEPEEKDKDKVKEVKVLKEKIVPKKLEVLPRKVDKEEESSNSIKRPWEMLKDASISTANVLSTVQQQVKKETRQSLVQIRQQTKMYSSVDDLSPEYCGLPFVKKLKILNERQKLAELEKAVRSSSLDCGEATEAEFDGNLTRSHSEACAIEYARKLAKFNKNETLERRNLKSILKKLSAGSRASSLETSIMPDPDLVTAELRKLMRAPTIEGYAARHSKLSKSVTFNYTMQSPPSESSGANVDVTGSGSTDGQVEDLKPEESSLPINLPNKFSIRPLGSDDVVKMLSRPDDECLGDLRDRVISQLQSRIIELERENPGRSSSGHENLDSGDDSTDLDVSLDEDTLRDHEEHPFMRDGSVDTVLGSARSSLTRSSIPTVEQRCRKRRSWEEHSEEETLQLQDLPRSISPQSVWRGDVAIDIESSDEDLPQRKIDDEDGDDEENSVDSDKPNDWEFKMLAEAIGKRKRSHETPSPGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H3T5</accession>
    <name>A0A8J2H3T5_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Similar to SIFaR: Neuropeptide SIFamide receptor (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HICCMSTLAB_LOCUS2114</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001116">
        <property type="protein sequence ID" value="CAG5076133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H3T5"/>
    <dbReference type="OrthoDB" id="5975505at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004983">
        <property type="term" value="F:neuropeptide Y receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042277">
        <property type="term" value="F:peptide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032870">
        <property type="term" value="P:cellular response to hormone stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000611">
        <property type="entry name" value="NPY_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24241">
        <property type="entry name" value="NEUROPEPTIDE RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24241:SF76">
        <property type="entry name" value="NEUROPEPTIDE SIFAMIDE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01012">
        <property type="entry name" value="NRPEPTIDEYR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 10" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 10 13" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 10" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="58"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="104"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="158"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="203"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="12">
        <location>
            <begin position="1"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAG5076133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="275" mass="31971" checksum="37EC04DD79AAD9A3" modified="2022-05-25" version="1">MKNLTAWVLGRFMCKTVSYIQGVSVAASVYSLVAVSLDRFLAIWWPMKCQITKRRARMIIVVIWFIALTATSPWLLFFDLIKYGDDPEMRFCVERWPRPQDGTLFFLIGNLLLCYVLPMILISLCYILIWIKVWRRNIPTDTKDAQMERIQQKSKVKVVKMLVVVVILFVLSWLPLYVIFARIKLGGEQAEWEEEVQMIATPIAQWLGSSNSCINPILYAFFNKKYRRGFMAILKSGRCCGKLRYYETVAIMSSSTSMRKSSYYVNNNSSTRLID</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H529</accession>
    <name>A0A8J2H529_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similar to CG15084: Coiled-coil domain-containing protein 130 homolog (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS873</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CWC16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001114">
        <property type="protein sequence ID" value="CAG5074101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H529"/>
    <dbReference type="OrthoDB" id="360327at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005684">
        <property type="term" value="C:U2-type spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007590">
        <property type="entry name" value="Saf4/Yju2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12111">
        <property type="entry name" value="SPLICING FACTOR YJU2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12111:SF2">
        <property type="entry name" value="SPLICING FACTOR YJU2B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04502">
        <property type="entry name" value="Saf4_Yju2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5074101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="263" mass="31125" checksum="9B64A593B0FB5F54" modified="2022-05-25" version="1">MKHELQPVIHENHIGFSLALFELRKNMSLDLFSPGVSCLKFSMRYEKFKICKQFECSLQLVRKSTQWKVINFVIILSEKMGERKGTNLYYPPDYDPRMGGLNKFMGTHALRERARKLHMGILIIRFEMPFNIWCNGCNNHIGMGVRYNAEKKKIGMYYSTPLYMFRMKCHLCDNHFEIKTDPANLTYIVETGARRQENRWDPTENEQIVPEEKEVSKRLYDDPMFKLEHSMDDKKKAKSQDTTLNAIIANNEQFFILKLEFKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H5F4</accession>
    <name>A0A8J2H5F4_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Similar to Retrovirus-related Pol polyprotein from transposon TNT 1-94 (Nicotiana tabacum)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HICCMSTLAB_LOCUS617</name>
        <name evidence="5" type="ORF">HICCMSTLAB_LOCUS618</name>
        <name evidence="6" type="ORF">HICCMSTLAB_LOCUS619</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001114">
        <property type="protein sequence ID" value="CAG5073813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CAJNRD030001114">
        <property type="protein sequence ID" value="CAG5073815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CAJNRD030001114">
        <property type="protein sequence ID" value="CAG5073817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H5F4"/>
    <dbReference type="OrthoDB" id="8063677at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054722">
        <property type="entry name" value="PolX-like_BBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47592">
        <property type="entry name" value="PBF68 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47592:SF31">
        <property type="entry name" value="ZINC FINGER, CCHC-TYPE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22936">
        <property type="entry name" value="Pol_BBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14223">
        <property type="entry name" value="Retrotran_gag_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="230"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="377"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="380"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="393"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG5073813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAG5073815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAG5073817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="410" mass="47064" checksum="F9BC88861EBFC34E" modified="2022-05-25" version="1">MAEKDTVNLIKLDGTNYQMWKFGITFLLDSKDLSDFVDGTVEEPDKVTKLADWKMWRKNRSQAAVILLSSVDQALHPNLINCSSPQGIWDKLKALYGEVSEDAAASAWQQYYDFKIVDSEPVNVQIEKFESICKKLENAGEKVSEKSVMSNLLSSLTPRFSAFRMAWECTAKDAQKIENLTVRIIREDKRLKGDEESETTLAFQVNAMRLKKQDRQEAAKRIQELKKRTRCNKCKKLGHWMRECPENLEDDRKYAGKNDEDLKTIETYVCETSALHSEISLKERDIWIADSGASMHIAWERGIFTTLQPSKEITFVKIADNKVLHTAGIGTVDIQVNLNGYNGESSNYRLWDKESRKIHVSSDFIFNEKQEVKGIENNENKYQTFDLSPVTSERTETDDQQHEEGSSTEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H5S1</accession>
    <name>A0A8J2H5S1_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Similar to HTR2A: 5-hydroxytryptamine receptor 2A (Pongo pygmaeus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HICCMSTLAB_LOCUS1813</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001116">
        <property type="protein sequence ID" value="CAG5075692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H5S1"/>
    <dbReference type="OrthoDB" id="5975336at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008188">
        <property type="term" value="F:neuropeptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24238">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24238:SF69">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR 165"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 12" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="73"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="127"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="230"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="271"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="11">
        <location>
            <begin position="49"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="339"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="346"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAG5075692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="389" mass="43799" checksum="39C788A1295B4250" modified="2022-05-25" version="1">MPFCTALTVKINALLINISKNNPNCIDTQNQCTFNHNLQKKFQDIPFHVSMMTYLLIAGDRYRLLSDPGKPRIPAFVCALGSWFFAICIVLPFPIYTTYLDLSSFKKGHFDGLGICLGNLVDDIQQYMRGLFLLTYVAPLAITAYIYVKSSRELQNKEDPLSAVAIFESRRKGSSRHDSDVSTDLMPYRDTKCRSGSLTTTTATAGLSAFTTNTYDPEIDVAKEIRSQKYLIFMVSYYAILLCPLMVLKLAKLALVETAENEGHFDITYTIFVWLGFTPTVATPILYASWQMSRPTKERLKGYFQSSSRRLTKVCEETVIRSNRHPSHQINPSGLANVAYTQHPRSGNGNNSSSGSNYNEAEGINYSRGNLSTRSSEFDNHPQNMYLVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H5X0</accession>
    <name>A0A8J2H5X0_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS2451</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001117">
        <property type="protein sequence ID" value="CAG5077418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H5X0"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5077418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="87" mass="9598" checksum="B7CB4B60EB712A09" modified="2022-05-25" version="1">MEFYGFGLSHVIFVICVSTHPIAIHHTMVQGYQNLLILQKRLNLNYQALKISRFVLFNISLPPLEALICATCSGVSINLLPLGSANA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H617</accession>
    <name>A0A8J2H617_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Similar to Gprk2: G protein-coupled receptor kinase 2 (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HICCMSTLAB_LOCUS2550</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001117">
        <property type="protein sequence ID" value="CAG5077756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H617"/>
    <dbReference type="OrthoDB" id="354826at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009966">
        <property type="term" value="P:regulation of signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.167.10:FF:000009">
        <property type="entry name" value="G protein-coupled receptor kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.167.10">
        <property type="entry name" value="Regulator of G-protein Signalling 4, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016137">
        <property type="entry name" value="RGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036305">
        <property type="entry name" value="RGS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044926">
        <property type="entry name" value="RGS_subdomain_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24355:SF28">
        <property type="entry name" value="G PROTEIN-COUPLED RECEPTOR KINASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24355">
        <property type="entry name" value="G PROTEIN-COUPLED RECEPTOR KINASE/RIBOSOMAL PROTEIN S6 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00615">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00315">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48097">
        <property type="entry name" value="Regulator of G-protein signaling, RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50132">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RGS" evidence="6">
        <location>
            <begin position="59"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="7">
        <location>
            <begin position="245"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG5077756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="384" mass="44466" checksum="C62B2781DDCD9F01" modified="2022-05-25" version="1">MELENIVANTVYLKAREGGGDSNKGKSKKWRKILQFPHISQCIYLQDKLDIKYSYVVDQQPIGRVLFRQFCQDLKPAYHRFNLLLDAIEKYEIEIDENRTELAKDLYEQYLKHENSEVSGILNDSVISQCEERISSAGKDLFVQVSSIVKNYLAGEPFLQFRSSFYFYSIIWDDIQCHLVLSVWLTSLVNIYQFFFINQEKYSHKFTEEAKNLCQQLLKKNPKNRLGCKCGRYGAKEIKLDSFFQCLNWKRVEAGMWDPPFIPDPHAVYAKDVLDIEQFSTVKGVNLDATDDTFYSQFNTGSVSIPWQTEMIETECFKELNVLGPDCSPTPDLLINYPLTNNDSRGCFPFRRKKKQNARTRQIPISDGHLLELSQSQGSELPAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H635</accession>
    <name>A0A8J2H635_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">coproporphyrinogen oxidase</fullName>
            <ecNumber evidence="4">1.3.3.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HICCMSTLAB_LOCUS2510</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="pathway">
        <text evidence="1">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; protoporphyrinogen-IX from coproporphyrinogen-III (O2 route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the aerobic coproporphyrinogen-III oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.3.3" evidence="4"/>
    <dbReference type="EMBL" id="CAJNRD030001117">
        <property type="protein sequence ID" value="CAG5077602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H635"/>
    <dbReference type="OrthoDB" id="15318at2759"/>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00322"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004109">
        <property type="term" value="F:coproporphyrinogen oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1500.10:FF:000002">
        <property type="entry name" value="oxygen-dependent coproporphyrinogen-III oxidase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1500.10">
        <property type="entry name" value="Coproporphyrinogen III oxidase, aerobic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001260">
        <property type="entry name" value="Coprogen_oxidase_aer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036406">
        <property type="entry name" value="Coprogen_oxidase_aer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018375">
        <property type="entry name" value="Coprogen_oxidase_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003727">
        <property type="entry name" value="PRK05330.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10755">
        <property type="entry name" value="COPROPORPHYRINOGEN III OXIDASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10755:SF0">
        <property type="entry name" value="OXYGEN-DEPENDENT COPROPORPHYRINOGEN-III OXIDASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01218">
        <property type="entry name" value="Coprogen_oxidas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000166">
        <property type="entry name" value="Coproporphyri_ox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00073">
        <property type="entry name" value="COPRGNOXDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102886">
        <property type="entry name" value="Coproporphyrinogen III oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01021">
        <property type="entry name" value="COPROGEN_OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG5077602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="387" mass="43859" checksum="43A3C9A6631BC505" modified="2022-05-25" version="1">MSRIFLSNLKVINSVIISCGKSKTASRLAYLGVGVIATGIVTYSSSKNEVYAAQPQLDVSKFMASPITPVEELKKNGSSMKSKMEILILKIQADFCKSLESFEDEERFKVDRWLRTEGGGGITCVMQEGKVFEKAGVNISVVSGMLPPGAIQQMRARGKQMDEGSLPFFAAGVSAVIHPRNPMIPTIHFNYRYFEVVNNDGTVQWWFGGGTDLTPYYLNEDDARHFHQTLKKACDQHDPSYYARFKKWCDEYFFIKHRGECRGVGGIFFDDIDTPNQDAAFKFVSSCAKSVIPSYVPLVAKHKDDGYGYAERQWQLLRRGRYVEFNLIYDRGTKFGLYTPGARYESILMSLPLTARWEYMHEPAVGSKEAQLMEVLRTPKNWLNIKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H7H6</accession>
    <name>A0A8J2H7H6_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Odorant receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HICCMSTLAB_LOCUS3418</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Cell membrane</location>
            <topology evidence="1 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the insect chemoreceptor superfamily. Heteromeric odorant receptor channel (TC 1.A.69) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5081943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H7H6"/>
    <dbReference type="OrthoDB" id="6617147at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005549">
        <property type="term" value="F:odorant binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004984">
        <property type="term" value="F:olfactory receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004117">
        <property type="entry name" value="7tm6_olfct_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21137">
        <property type="entry name" value="ODORANT RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21137:SF35">
        <property type="entry name" value="ODORANT RECEPTOR 19A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02949">
        <property type="entry name" value="7tm_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 10" id="KW-0552">Olfaction</keyword>
    <keyword evidence="8 10 11" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="9 10" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="38"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="129"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="193"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="266"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="297"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU351113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAG5081943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="394" mass="46038" checksum="F9D8563DA63BD938" modified="2022-05-25" version="1">MEKLSSDQKQLDESVKIFDYSRRVSKAVGLWPLASNDYIFTFSYCYFTVIMIFEWMDLYYSLDDLNDVLDNLTENLSYTQIYIRGIILRIHMNRLKKIIKNTIGDFNINSFKNPSEIKIFMTYIKKGRFFVKSIISFMAMTVITWYFQPLTTPAPVASDNETIMFFLPYRCHIIFEINDSKSYMLTYIAFAPYTWIHGCSHASVECFLITLVYYLRGRLVILAGRIDRLSGMETLEWKNDFQDIIVEHIRLLKLGNNVIDIYSTSLMVYMICTTICICVIGYKILVNCMTGPDADLVQFFIYVFAVYLIMAVFCFISEQLMSECDEVSEAFWNCEWYRMPPKTVVNVMFCIQRSQQPLTLKIGKFAHFGNNMLTVVTKTAMGYLSVLRNFLVID</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H7I0</accession>
    <name>A0A8J2H7I0_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="21">Similar to ft: Cadherin-related tumor suppressor (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">HICCMSTLAB_LOCUS3512</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5082279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6252479at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048589">
        <property type="term" value="P:developmental growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001736">
        <property type="term" value="P:establishment of planar polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007163">
        <property type="term" value="P:establishment or maintenance of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008104">
        <property type="term" value="P:intracellular protein localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030182">
        <property type="term" value="P:neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120036">
        <property type="term" value="P:plasma membrane bounded cell projection organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050793">
        <property type="term" value="P:regulation of developmental process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051239">
        <property type="term" value="P:regulation of multicellular organismal process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007423">
        <property type="term" value="P:sensory organ development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd11304">
        <property type="entry name" value="Cadherin_repeat"/>
        <property type="match status" value="17"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="CDD" id="cd00055">
        <property type="entry name" value="EGF_Lam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00110">
        <property type="entry name" value="LamG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000029">
        <property type="entry name" value="Cadherin EGF LAG seven-pass G-type receptor 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000104">
        <property type="entry name" value="cadherin-23 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000207">
        <property type="entry name" value="Cadherin-related tumor suppressor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000286">
        <property type="entry name" value="Cadherin-related tumor suppressor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000020">
        <property type="entry name" value="Dachsous cadherin-related 1b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000116">
        <property type="entry name" value="Dachsous cadherin-related 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000033">
        <property type="entry name" value="FAT atypical cadherin 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000037">
        <property type="entry name" value="FAT atypical cadherin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000080">
        <property type="entry name" value="FAT atypical cadherin 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000039">
        <property type="entry name" value="FAT atypical cadherin 3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000101">
        <property type="entry name" value="FAT atypical cadherin 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000106">
        <property type="entry name" value="FAT atypical cadherin 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000118">
        <property type="entry name" value="protocadherin Fat 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000472">
        <property type="entry name" value="Uncharacterized protein, isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.60">
        <property type="entry name" value="Cadherins"/>
        <property type="match status" value="17"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002126">
        <property type="entry name" value="Cadherin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015919">
        <property type="entry name" value="Cadherin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020894">
        <property type="entry name" value="Cadherin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001791">
        <property type="entry name" value="Laminin_G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002049">
        <property type="entry name" value="LE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24026:SF133">
        <property type="entry name" value="CADHERIN-RELATED FAMILY MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24026">
        <property type="entry name" value="FAT ATYPICAL CADHERIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00028">
        <property type="entry name" value="Cadherin"/>
        <property type="match status" value="17"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00008">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00054">
        <property type="entry name" value="Laminin_G_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02210">
        <property type="entry name" value="Laminin_G_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00205">
        <property type="entry name" value="CADHERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00112">
        <property type="entry name" value="CA"/>
        <property type="match status" value="17"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00282">
        <property type="entry name" value="LamG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49313">
        <property type="entry name" value="Cadherin-like"/>
        <property type="match status" value="17"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00232">
        <property type="entry name" value="CADHERIN_1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50268">
        <property type="entry name" value="CADHERIN_2"/>
        <property type="match status" value="17"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50025">
        <property type="entry name" value="LAM_G_DOMAIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8 14" id="KW-0106">Calcium</keyword>
    <keyword evidence="9" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="12 15" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 15" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="5 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="2732"/>
            <end position="2755"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="20">
        <location>
            <begin position="82"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="20">
        <location>
            <begin position="185"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="20">
        <location>
            <begin position="291"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="20">
        <location>
            <begin position="397"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="20">
        <location>
            <begin position="500"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="20">
        <location>
            <begin position="609"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="20">
        <location>
            <begin position="716"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="20">
        <location>
            <begin position="821"/>
            <end position="922"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="20">
        <location>
            <begin position="924"/>
            <end position="1028"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="20">
        <location>
            <begin position="1029"/>
            <end position="1132"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="20">
        <location>
            <begin position="1155"/>
            <end position="1265"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="20">
        <location>
            <begin position="1266"/>
            <end position="1372"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="20">
        <location>
            <begin position="1373"/>
            <end position="1476"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="20">
        <location>
            <begin position="1477"/>
            <end position="1582"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="20">
        <location>
            <begin position="1583"/>
            <end position="1688"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="20">
        <location>
            <begin position="1689"/>
            <end position="1794"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="20">
        <location>
            <begin position="1795"/>
            <end position="1902"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="19">
        <location>
            <begin position="2147"/>
            <end position="2183"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="19">
        <location>
            <begin position="2186"/>
            <end position="2224"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="19">
        <location>
            <begin position="2226"/>
            <end position="2262"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin G" evidence="18">
        <location>
            <begin position="2263"/>
            <end position="2456"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin G" evidence="18">
        <location>
            <begin position="2531"/>
            <end position="2715"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="2819"/>
            <end position="2880"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="2912"/>
            <end position="2953"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="2995"/>
            <end position="3172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="2819"/>
            <end position="2854"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="2865"/>
            <end position="2880"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="16">
        <location>
            <begin position="2920"/>
            <end position="2932"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="3006"/>
            <end position="3043"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="3060"/>
            <end position="3078"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="3097"/>
            <end position="3106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="3107"/>
            <end position="3130"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="2173"/>
            <end position="2182"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="2195"/>
            <end position="2212"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="2214"/>
            <end position="2223"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="2252"/>
            <end position="2261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="CAG5082279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="3261" mass="355406" checksum="B887455EC9FCA1A4" modified="2022-05-25" version="1">MAVFYRNNKPFESNQIILRVRSNVIASKDPSGIILSPVGRQNDLALLPAPINIYRNRVIVGRSCVTVRVTVLDKNDVAPSWGPGPWRFEVSEEAPPNTIVTVLKAQDPDTIGNLRYSLITSPKISPNDYNYEDPYSPASDRGIEGQFRLDPINGQLRLVEALDRETREKYVLKVTDTNDNAPVFQSMAYSFDVAENVPRGSRIGQVIATDADADGPNSQLSYALISDWANDVFSLNPSTGVFTLTASLDYEQVQHYILVVQATDGGLPVLSTTVTVYCNVVDLNDNAPIFEPGPHGADVLENTTTGTAVLSVVAQDLDSGDNGRVVYDIINGDDNGDFGIASNGTVFTRKLLDRETKSIYNLIIRAQDSPTLAVKPLSSTVQVTIVLLDVNDVAPEFISSNQTSIMENSPPNTVVMAIKAVDKDEGRNGYVEYSLKEPSLSFNLGAVDGLLRIAEPLDRERRQNYTLRISAKDRGEPPKSSEATITVLVLDENDNAPIFDPKQYSATVAENASIGASVLQVSATDRDEGANGRMRYSIALGDENRDFTISEDAGVIRVAKNLNFERKSRYRLTVKAEDCAPEIGEPSRDDTAEVTITVLDINDNAPVFLDSPYLAYVMENMVPPGGGFVIQVKAYDADTPPYNDQVRYFLKEGDTDLFRINASTGDIFLLRPLDREMIPDYTLTLVAMDTGSPPLTGSGVLKVIVLDVNDHSPEFSRPDYKATVTENNPGGTWVAKPTATDKDEGLNAKIRYSLLGEKTERFSVNPDTGEIVTLVSLDREQTAIYHLTLIAQDSSPTEPRAAAVNLTIYVADVNDNAPRFSSPRYTAYVPDSTKPGDFVFGAKAVDDDDGENSRIVYHLQGDDAHRFVIDNSNGVIRAAEDLSNAKATYQLQIRASDCGQKSQSVTADLVIHLWDRQLFPSFKSSISTRFTLTEDMPEGRIITTLSATTPKVGAASNLVFAMAGGNVGDALRIDSSTGEVLVASGFDYETAPTYEAWVEVRDSDNPPLRSVVQLLINVTDANDNPPIMEAVIYNATVLEEEYPPLYVTKIAAKDLDSGENGLVTYYLANDYDESFMIDENTGEISTNAKLDREEMNSYELIIEARDQGEPRLSGTATVIVSVLDKNDNPPRFTRLFSVNVTENAEDQNDNAPEFTEESYHFHFPELQRRLAHVGQVAAADRDKQGPNSVISYSLQHPSDLFSVDPATGDIFSKRTLRYKHTHRPSSPENLYSLTVIATDNGKPPLSSKTIVHVSVVDANNNAPKFEQRTYLSPVPEAYGVGKRVVKLTAHDDADFGVNAEIEYTVAGGNSSDFFGIEAKTGWIYVTKSIKDIPVGTTFLLAVRATDKGVPPQKDQVSLMLVVTGENRRAPTFAAVSYQVRVPENEPVNTTILTVSAVDGDDGPNGMIRYKISDSECRVFSIHPTTGAITILETLDYDTIQEYRLNITATDLGFEPKQAVATLTINVSDINDNPPTFNQTVYEAFLPENSRPSSFVYKVVARDIDSPKYAVIQYRIIGGSGKEHFQIQQDTGVVTSRITFDYEEANKYTLDIVAANPDSNPQMVGFTTVVVHITGVNEFYPKFIQPVFLLDVSESAEVGTSVGLVQATDQDAGDDGRVYYLFVGSSNDRGFSIGSETGIISVSRHLDRETQNRAVLTVMAKNAGGIRGNDTDEAQVIISIQDGNDPPEFLQTTYESSVSEGAIQGTRILTVRAIDKDVRPQNNQFSYSIIGGNVGQAFKVDPQSGDVETAKLLDRESIASYQLIIGAIDVGSPPQTGTATVRIDLLDINDNGPVFDPPEIVGYVNENEPAGTSIMTLTAMDPDLPPNGAPFTYRLIGGRQADVVTLDKHSGVLRTTRSLDREVMPQLDLLIEVEDSGLPKMKSEHTVTVIVLDENDSPSTPRSVHIIVHSFNGKTPMGKIADVHPNDPDTTGDYTCKILQGSNPAGVLTVPIACDLHTSKITPGLGYSLSISGRDGRHPDVVSKVTVEFLVFSNATVENSVTLQINRLTAAEFLAKFYRPLLDMLQDDVDTGDTFTIFSIGETDGNLDIYLAMETPQGFKAKAEVIDMLVRKREKIQETLAGSGVTVNYSPCGLMACDNGGSCSDQLVVYEDARITNSQSLILTSPRVTHEMICRCREGFTGARCERRQDPCSPNPCLERGQCRRVGYDFMCSCPANREGKLCELERGDACASNPCRNGGSCKVSPDGSSFFCLCRAGYRGNHCEAVTDSCRPNPCLHGGLCVGQKPGYRCSCPEGHYGRHCEQSTYGFDELSFMSFPALDSTTNDITIVFATTKPDALLLYNYGPQSGGRSDFIVLELINGRIAFSYGGARSAITLVKVEGGSRLDDGHWRKVTATRNGRVVSLSVSNCREHGDVCDECKPGDGSCYADDIGPTGTLNFNNNPLMIGGLASADPVLERPGQVHSDDLVGCVHSISINGRALNLTSPLASRGIKNTCPRPENGVCDDLQSVCGSGKCYDKWHLASCQCDSLTAPNCRGALEPVNLSDGGYVEFKISEKHKRMQLLEYLYGGTTSWSRNKVTRRAAKEDTNNLISLGVPPPKKMSLMFRTIKTDGILIYAATNKHYTSIELKNGQLSYTSLLGSAVNMTGAVEGGLADGRWHNLTIFAHSRGLQVIIDGQLTGDELDSAGVHDFLDPYLTVLFVGGVRRDLYYHDSYPVTFEGCIANFSINNELQPFNGSGSILKDVMYHGKVSRGCRGPIGISAAATADPLSIGITLVIVFFVTLLVAILVSFVVFRLRRQSKEKAPSVVNKNTNAIITGNSLVGSGNDGLMSRHENTYISDTSDLRGVGHMGPELISKKFKERELNSTEHQRPQRPDIIEREVTKSPMIRDEHPPMPPPTQSSLHSHEHNPEPDMPEHYDLENASSIAPSDIDIVYHYKGYRDGMRKYKATPPPIGSYGNHHKHSGTPHRHAGAFPPRAMPPPSVGQPTTTPKLLQSTPLARLSPSSELSAQQPRILTLHDISGKPLQSALLATTSSSGGVGKDALNSNSERSLNSPIMSQLSGSTASRKVPQSANDTSNNVPTGPMGLTAEEIERLNSRPRTSSLVSTLDAVSSSSEARGPPPPHGPLHLHRRHTPPTERLERRNSSTTDESGNDSFTCSEIEYDNNSLVGDKRSDNLYSKPEDEDPPTRTDGSPQSTKPPLPPNVSYDGFDSSFRGSLSTLVASDDDLSTHMGSLYRPTNNGSPSTNTALSWDYLLNWGPNFESLVGVFIDIAELPDSNRVPNTLRLPASIPKPSEEYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H8J8</accession>
    <name>A0A8J2H8J8_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS4289</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5085157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H8J8"/>
    <dbReference type="OrthoDB" id="7700372at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="179"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="198"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="209"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="225"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5085157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="247" mass="28794" checksum="90793AD38CCECD6E" modified="2022-05-25" version="1">MENAFIKFTASLHTILMRLNYKLNVVDYRVKPITRIHLFCFFMHVAKWWALVKWIGGNDNKKMTAEIDVRHIKDFNLDSYFEENHDPQTVYVVEWHDTIKMPLGGWNFYKAMVGDVSKSIKTLQKKLDALEGIKSPGPFIKRVEVLEQISDKDDVEEIKELENPKKKLRFSDKNQGDVLNEEEVEVLETPSEAKRPENNTSSHVPTSKSKFEEGHSSKDDLKKKESSKKKILKHQCHPVVKTLKKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H958</accession>
    <name>A0A8J2H958_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS3879</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5083585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H958"/>
    <dbReference type="OrthoDB" id="7699805at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5083585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="101" mass="12127" checksum="ECD34ED6490FCA9B" modified="2022-05-25" version="1" fragment="single">MRKNIYTKDIRRPYKRELGWLSVKSHRMYYLACYFYKLLSIGKPSYLRELFIEDIDTRHSVRLAAKKLPKFATTIYELSFIVTCIHLWGREELPIDLINAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H9I9</accession>
    <name>A0A8J2H9I9_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS4636</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5087889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H9I9"/>
    <dbReference type="OrthoDB" id="302535at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017046">
        <property type="term" value="F:peptide hormone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038023">
        <property type="term" value="F:signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052612">
        <property type="entry name" value="ANP_Clearance_Receptor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44755:SF11">
        <property type="entry name" value="ATRIAL NATRIURETIC PEPTIDE RECEPTOR 3 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44755">
        <property type="entry name" value="NATRIURETIC PEPTIDE RECEPTOR 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="Periplasmic binding protein-like I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="126"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5087889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="150" mass="16517" checksum="305E27106AAB213E" modified="2022-05-25" version="1">MIAAKNNNNNNNNNINKTLVVCEAVIITGTQLPGKHWSSTRVNAVPSDINRRVVKIGVIAPADPHHEQSLPRILPAVALAVKAVSSTKGPLPGWTISVTYRDSKCSSTHGSLAAFDFYINRTAGHYFLINYQYFTLFLLLLSFYFPTAVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H9U0</accession>
    <name>A0A8J2H9U0_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS4286</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5085146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H9U0"/>
    <dbReference type="OrthoDB" id="7694954at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579">
        <property type="entry name" value="F5/8 TYPE C DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579:SF1">
        <property type="entry name" value="F5_8 TYPE C DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5085146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="715" mass="82396" checksum="DB36322C992034B1" modified="2022-05-25" version="1">MLILLNICKEFYYELKNWPSYLSGLHKASSFVENPRSLSPSAILDSDPESVCDTSNFSVPQGIFVYDSNEEYCESDTLEDSDTELSDDFADSDDDSNDYVEGEMNVYLETTLNDNQNPCIDEARQLSNTIRYPKAVLIRTLLILSIKVKKSLDNETVQLIAGLVDSLSDEPSNCTTSYHFKKIIDSYSFPFEIHHLCPTCGLYIGVQCKTEDESTLRCEKCNIDVPIKKKINVQKTLKEFCSHNHESLLYPIQRKKQCYFAIEDIMDGKLYNLDSSSEDSLSLNFNVDGTPLFKSSQTSITPVLCTINELHPQERKKHVMLVIKIPIGVCDSVERPNLRCSKSFRGEYGCGLCKHPGEEMQKGAGHVRVYPIDAEGNAFGEGLRSHSETAMHAEEREKGIKGRSKLFDIPNYDIIKNLTVDWMHCIALGVCRQFLKLWFDPQYHAKSFYLGRVINDIDYFITSIKPSLDITRTPRKISDRLHLKAHELVIWLLFYSLPSLKRYLPRKYFNHWKSLRSMIAFRKLEECYEHDLTLIQREFLKKSINKKKYSSNSTKIDKIKMIRKGLIQDLPGSHCLALRQIDVRVDDNSDVLYYKRIITNNEVIHSKSYTKVQKRNSYTVLLSNTEVFESDIFIHVEVQQNDRCLALGRYMNKCRNNFFPNVQLKHLIFTKIPDLQEPLAAIDAKLIQQKVTIIHDSADDVHIACIHPNKYELLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H9U2</accession>
    <name>A0A8J2H9U2_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Similar to TRPC5: Short transient receptor potential channel 5 (Oryctolagus cuniculus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HICCMSTLAB_LOCUS4652</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5087935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H9U2"/>
    <dbReference type="OrthoDB" id="2373987at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034703">
        <property type="term" value="C:cation channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070679">
        <property type="term" value="F:inositol 1,4,5 trisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015279">
        <property type="term" value="F:store-operated calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051480">
        <property type="term" value="P:regulation of cytosolic calcium ion concentration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002153">
        <property type="entry name" value="TRPC_channel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10117">
        <property type="entry name" value="TRANSIENT RECEPTOR POTENTIAL CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10117:SF54">
        <property type="entry name" value="TRANSIENT RECEPTOR POTENTIAL-GAMMA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01097">
        <property type="entry name" value="TRNSRECEPTRP"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0407">Ion channel</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035225715" evidence="9">
        <location>
            <begin position="16"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="56"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="86"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="127"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="157"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="198"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="244"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="Ion transport" evidence="10">
        <location>
            <begin position="88"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAG5087935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="467" mass="54672" checksum="0170FEFD8F11D646" modified="2022-05-25" version="1">MVFSMNFIFPRLLLAIECKQKAFVAHPNVQQVIENKWIGEWYGWTKKSRAAKIATVFWRIPTFWFMALWVWVAPGSKRGRKWQIPVHRYISIVASYLVFLTICFLQSNVNKKNQLRGPPNTGCEVPLVIYVISFIWAAIRLCMIHGPSRYFRSRWNWYEVVMLILFIMTFIFWIASAIDVRLHDQRDLERKYWHKYDPTLVAEGTLCLATIMAFFKLIFLCQLDYNLGQLQVTLGKMIQDATKFLLLFCIIIFAFAAGLARLYQYYDGMVQVDDESKIKIQQVSSFVDFLSTLKTLFWAIFCMSTIESADVIIENIPGESFECISVIVVLNMLIACMSNTFTAVTRNVDVEWTFARTKVYVNIMALNSLPPPFNLLPTCSEYRTIVEFVKLLFRPTKTKRARWNFKHGCYIENTAENNNEKFEEIMGLLVMRYFRKKHVESETNEIRGLRKDLNELRYLLKDALSPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H9V9</accession>
    <name>A0A8J2H9V9_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS3890</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5083629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H9V9"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5083629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="135" mass="14450" checksum="38660F7B42EF69A0" modified="2022-05-25" version="1">MFMNNSIANLEFRIEAESCWTWHWAHLINPQDFGSFTTPNSLHWPLGTGEGVIGGPFSGVQVSSSVFSVPGTLVSGTVVSVEPFGTVVLVKSPETVVLVEPFGTVALAEVPLVPRKSSVSILQTMAPPRPIFLAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H9W2</accession>
    <name>A0A8J2H9W2_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to Saxiphilin (Lithobates catesbeianus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS4616</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5087822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H9W2"/>
    <dbReference type="OrthoDB" id="5914301at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055037">
        <property type="term" value="C:recycling endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001156">
        <property type="entry name" value="Transferrin-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11485">
        <property type="entry name" value="TRANSFERRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11485:SF29">
        <property type="entry name" value="TRANSFERRIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00405">
        <property type="entry name" value="Transferrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51408">
        <property type="entry name" value="TRANSFERRIN_LIKE_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transferrin-like" evidence="2">
        <location>
            <begin position="1"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5087822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="129" mass="13968" checksum="2E17AAC496903B0B" modified="2022-05-25" version="1">MKDSSINKLADLKDKKSCYTFYKSDFTGWLAPVQVLKKAGLITSEEGLGEFFGGSCAPGASKTSPLCQQCVGDMESQDDQNKEATKCQPTQAEDFSDSKGALSCLTSGHGDVAFVPYTVLEKIKYLFSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HBC2</accession>
    <name>A0A8J2HBC2_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="17">CYP9R40</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">HICCMSTLAB_LOCUS6255</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="2">May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 14">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Endoplasmic reticulum membrane</location>
            <topology evidence="4">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Microsome membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 15">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5092616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HBC2"/>
    <dbReference type="OrthoDB" id="2789670at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11056">
        <property type="entry name" value="CYP6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000042">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050476">
        <property type="entry name" value="Insect_CytP450_Detox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24292:SF54">
        <property type="entry name" value="CYP9F3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24292">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 14 15" id="KW-0349">Heme</keyword>
    <keyword evidence="11 14 15" id="KW-0408">Iron</keyword>
    <keyword evidence="13 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 14 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0492">Microsome</keyword>
    <keyword evidence="12 15" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="10 15" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="14">
        <location>
            <position position="449"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CAG5092616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="507" mass="58183" checksum="E2A17292F0AE2F48" modified="2022-05-25" version="1">MDISWTIILGSIIGLLFLLNYILSRERNFAQYGMPFVPKHSIFYDIIQVLLKRLSIVNQTLKIYWHDDTAKYIGYHEFSKPVIMIRDPELLKSITVKNFEHFVDHRSFGDPEMEPLFSNNLFALKGDKWREIRTLLTPAFTSSKMRAMFMLMSECANNFTESLLEQIQKTNEFNSKDIFSRYTNDTIATCAFGVAVDSMKNPTNDFYVLGRKATNFEGIQMLKFVITMSSPKLAKFLRLKLFDKEADSFFLNLVRDTITTRDEKNIHRPDMIQLMMETRNQEPGSKKPELSIEKMTSQAFIFFFAGFDTTSTLMSFAAHEISVNTDVQKRLQEEIDEVLERCDGDPSYEAINAMQYLEAVVYEALRLYPAAVAVDRVCTKDFELPPAVPGAKPYMVKEGDALILPMWAVHRNPKYFPDPEKFDPERFLGDKEALHSPAYFPFGVGPRMCIGNRFAILETKVLFFHLLAKCTIKPAKKMKLPMKISSSSVAVTAEGGFWLEILARKGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HC52</accession>
    <name>A0A8J2HC52_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similar to RpA-70: Replication protein A 70 kDa DNA-binding subunit (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS6448</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5092929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HC52"/>
    <dbReference type="OrthoDB" id="1751331at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007199">
        <property type="entry name" value="Rep_factor-A_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04057">
        <property type="entry name" value="Rep-A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Replication factor-A protein 1 N-terminal" evidence="1">
        <location>
            <begin position="6"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5092929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="119" mass="13585" checksum="F96FBCAC0CC52615" modified="2022-05-25" version="1">MDPILSWRAIEQITEQGLKIEKPNLQFLGFKKVMCADKERYRVFLNDGITSNSFAMLAPELNHLITNNILTMYSIVQITRYGLSEAKKGDEIINVMVILDLKIQRPGREVPGEINFASE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HCE7</accession>
    <name>A0A8J2HCE7_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to INO80B: INO80 complex subunit B (Homo sapiens)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS5342</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5089704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HCE7"/>
    <dbReference type="OrthoDB" id="2021186at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031011">
        <property type="term" value="C:Ino80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23021">
        <property type="entry name" value="zf-HIT_IN80B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029523">
        <property type="entry name" value="INO80B/Ies2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006880">
        <property type="entry name" value="INO80B_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007529">
        <property type="entry name" value="Znf_HIT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21561">
        <property type="entry name" value="INO80 COMPLEX SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21561:SF12">
        <property type="entry name" value="INO80 COMPLEX SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04438">
        <property type="entry name" value="zf-HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01406">
        <property type="entry name" value="PAPA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="INO80 complex subunit B-like conserved region" evidence="2">
        <location>
            <begin position="166"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="68"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5089704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="290" mass="32839" checksum="E7D109DF58F0BDEA" modified="2022-05-25" version="1">MVKPKEAISEIGLNIETISQKRHKKHKHKKHKKKKLIHEAVLGSSLLDRKKMLNRVKKVEIDDSKLVKTPVGTSTSPKSKKKVLKNGKGKDSGTSSEEERWLDAIESGKLEEVDDELKKIKPKDPKLMTARQRAMFERKTDTEPNPGVEQLMSLPTGYKEKVMTAEAIQKAALKSLKRKQMADEKREKDKKKTMERLLKKQESKTKIMSKGKIKRQVPLVTYRITLEGSSISLPPGVDFPLPPTSIKRTLEVIKCGVDDCESPKRYSCSRTGIPLCSLRCYKANIARILA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HCW0</accession>
    <name>A0A8J2HCW0_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">small monomeric GTPase</fullName>
            <ecNumber evidence="3">3.6.5.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HICCMSTLAB_LOCUS7509</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.2"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Early endosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.2" evidence="3"/>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5095038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HCW0"/>
    <dbReference type="OrthoDB" id="63533at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003925">
        <property type="term" value="F:G protein activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01860">
        <property type="entry name" value="Rab5_related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000180">
        <property type="entry name" value="Member RAS oncogene family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47978">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0967">Endosome</keyword>
    <keyword evidence="9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0636">Prenylation</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAG5095038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="232" mass="25676" checksum="DF296483B97C2D6D" modified="2022-05-25" version="1">MGTRQPGTTTRPMCISVSQCIFCIAHTDDGVWRIVMANRGTVAQRPNGTQGKICQFKLVLLGESAVGKSSLVLRFVKGQFHEYQESTIGAAFLTQTVCLDDTTVKFEIWDTAGQERYHSLAPMYYRGAQAAIVVYDIQNQDTFVRATTWVKELQRQASPSIVIALAGNKADLANKRMVDFEEAQAYADENGLLFMETSAKTAMNVNDIFLAIDVYVLCTCQSGKYNVSRGTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HDY5</accession>
    <name>A0A8J2HDY5_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to U-scoloptoxin(01)-Cw1a (Cormocephalus westwoodi)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS5874</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5092035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HDY5"/>
    <dbReference type="OrthoDB" id="6407151at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.140.10">
        <property type="entry name" value="Chitin binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002557">
        <property type="entry name" value="Chitin-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036508">
        <property type="entry name" value="Chitin-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052976">
        <property type="entry name" value="Scoloptoxin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22933">
        <property type="entry name" value="FI18007P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22933:SF43">
        <property type="entry name" value="LP10131P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01607">
        <property type="entry name" value="CBM_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00494">
        <property type="entry name" value="ChtBD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57625">
        <property type="entry name" value="Invertebrate chitin-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50940">
        <property type="entry name" value="CHIT_BIND_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chitin-binding type-2" evidence="2">
        <location>
            <begin position="20"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="137"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="153"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5092035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="168" mass="19437" checksum="9B354C564A503893" modified="2022-05-25" version="1">MPELLLPSNASLIRENIVDTFSCENRIYGYYADIDNECQVFHVCMPQNRGSRRWSFICPSETVFNQATFVCTRINESIPCEESEQYYILNEDIGKEEPEPENETNEVEENPSSQEPSYAPENGYTNDLPSVTPFSRRNPRPRVLRRRGKNSRFDTTQPNVISTTPLNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HEH1</accession>
    <name>A0A8J2HEH1_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Similar to dpy-19: C-mannosyltransferase dpy-19 (Caenorhabditis elegans)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HICCMSTLAB_LOCUS5999</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the dpy-19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5092250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HEH1"/>
    <dbReference type="OrthoDB" id="6019623at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005637">
        <property type="term" value="C:nuclear inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000030">
        <property type="term" value="F:mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018732">
        <property type="entry name" value="Dpy-19/Dpy-19-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31488:SF1">
        <property type="entry name" value="C-MANNOSYLTRANSFERASE DPY19L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31488">
        <property type="entry name" value="DPY-19-LIKE 1, LIKE (H. SAPIENS)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10034">
        <property type="entry name" value="Dpy19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="150"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="203"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="231"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="283"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="337"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="400"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="434"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAG5092250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="685" mass="79485" checksum="BE03A873472FB64C" modified="2022-05-25" version="1">MIMDIPDRYYRFIVALIALVCGLLHRDYVSMLFENDRHFSHLSEVEREMSFRTEMGMYYYYFKLITEAPTFFEGLKLLWNDSSSQYPREINAQKIYNLFPEITAGFLYHKAKEFDLLDAPQCWQIERGDGLSTVRSCQGLAVPSYFYTEFVWYFAGMTGAIIFLYGTYLSDSIFGGLIAFLSFLINHTECTRVQWTPPLRESFAYPILLWQMYAVTVVVDKYRYKNVDKKFNWRYIFKDFPFLYIFIPTLLSLTCWQFSQFVMMTQVVALLILHWLRILPKILILQLTSVHLLSIVASGFFGNLSSFSVYATLVVGVLYTNDLLVRLENILSANTLVFLEIVTTFGFTYLQQFILIVAFEDHSHIFDILKAKLTNYKNFHTLLYTCSAEFDFLPYESYEAIVRSFLLPFAILAGIMALYYWYRNFKIAGWPDCIEASVAYNALQTGAFVLMAAMIMRLKLFMNPHLCLIAGLVVSRRYLEKLGLRNEIFRDVFVLTVIAGLCYNGFVGIENEGKSYGEFSNVEQEELFDWIKGNTPEDAVFAGKMSLMANLLLTTRRPVVNNPFYESKIMRDRTLKVYEIYGRKDAAAVYETLRKMQVDYLVIDEGLCYGLGNPKPGCKLIDLWDVMDNGQAKRLGKRPLCPTLSERNSHPFKRVFANNHYVVLRLDYSTYVEFMPSSPMVLQSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HEH6</accession>
    <name>A0A8J2HEH6_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Forkhead box protein N3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HICCMSTLAB_LOCUS8162</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Acts as a transcriptional repressor. May be involved in DNA damage-inducible cell cycle arrests (checkpoints).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5096342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HEH6"/>
    <dbReference type="OrthoDB" id="5954824at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000987">
        <property type="term" value="F:cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20059">
        <property type="entry name" value="FH_FOXN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047404">
        <property type="entry name" value="FH_FOXN3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001766">
        <property type="entry name" value="Fork_head_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047119">
        <property type="entry name" value="FOXN2/3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018122">
        <property type="entry name" value="TF_fork_head_CS_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030456">
        <property type="entry name" value="TF_fork_head_CS_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13962:SF22">
        <property type="entry name" value="FORKHEAD BOX PROTEIN N3-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13962">
        <property type="entry name" value="FORKHEAD BOX PROTEIN N3-LIKE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00250">
        <property type="entry name" value="Forkhead"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00053">
        <property type="entry name" value="FORKHEAD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00339">
        <property type="entry name" value="FH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00657">
        <property type="entry name" value="FORK_HEAD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00658">
        <property type="entry name" value="FORK_HEAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50039">
        <property type="entry name" value="FORK_HEAD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Fork-head" evidence="10">
        <location>
            <begin position="258"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Fork-head" evidence="8">
        <location>
            <begin position="258"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="113"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="348"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="539"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="117"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="160"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="355"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00034657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00034870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAG5096342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="570" mass="63565" checksum="3E792731E664DD01" modified="2022-05-25" version="1">MAPDRPDASGLEATCGLTVTRVFNIVDSVVTFKKADNTSAFADKNNIATVDVASSDVISNPTVVKNFNDLGNPLITKINQSDDDLTSLTWLHQQNLLKGLEISSPTKNIKDENIFINNNNNNDNKNNNNNNNNNNNNNNTNNNNNNINNNNNVCEDSTELSENTNSISSLDDNYFPENNGKISSPGAGKLCLSYQNSDQTHEKSEPFYHQDTGKNSYNGMQQSNQVKISLNNNNLPVSNRNKHPTHIPYDPHLHRNSKPPYSFSCLIFMAIEDSPMKALPVKEVYAWILDHFPYFRNAPTGWKNSVRHNLSLNKCFRKVEKAPNLGKGSLWMVDDQYRPNLIQALSRAPFPPPTGQNLSSPDKNMKKNTSTRLPDPVLFPYLSKRLASSNIIDSTELEFDSDVDAAAAAMLSFKHGPIILNHNKERKRKSNIEPEKLIPIITRSSSEDHTYSCITSLKSDSKASNSSILDNIGLGVNDVDEQRKIAEGADALLNLAGIPFINNSAQEIPINTVSTSSVINHTIKLPLIQVSSSKSKRRITSSDYSSLPDKRRKRWREWGGSNRYPKQVRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HF66</accession>
    <name>A0A8J2HF66_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Early embryonic (Strongylocentrotus purpuratus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HICCMSTLAB_LOCUS6449</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Histones H1 are necessary for the condensation of nucleosome chains into higher-order structures.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the histone H1/H5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5092930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HF66"/>
    <dbReference type="OrthoDB" id="10070184at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031492">
        <property type="term" value="F:nucleosomal DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030261">
        <property type="term" value="P:chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045910">
        <property type="term" value="P:negative regulation of DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006334">
        <property type="term" value="P:nucleosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00073">
        <property type="entry name" value="H15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000140">
        <property type="entry name" value="Histone H1.0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005819">
        <property type="entry name" value="H1/H5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005818">
        <property type="entry name" value="Histone_H1/H5_H15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11467:SF20">
        <property type="entry name" value="H15 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11467">
        <property type="entry name" value="HISTONE H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00538">
        <property type="entry name" value="Linker_histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00624">
        <property type="entry name" value="HISTONEH5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00526">
        <property type="entry name" value="H15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51504">
        <property type="entry name" value="H15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0158">Chromosome</keyword>
    <keyword evidence="5 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="H15" evidence="9">
        <location>
            <begin position="40"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="118"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="133"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="159"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="189"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="217"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAG5092930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="234" mass="24029" checksum="CA342421BAF996F6" modified="2022-05-25" version="1">MTDTEVAAAPAPVEAKMIAKVNTPKKVKEVKAKKPATKATHPSAGDMVTAAVKALAERHGSSLQAIKKYIAANYKVDVDRQALYIKKFLKSAVEKGTLVQTKGKGASGSFKLGVIKAAAKPKPKTASVEKKKAAPKKATAKKPAAKKTSEPKVSVKKATGPKKAAKKPASPKKAKAPAKPKAAAEPKAKKAAAPKAKKAAKGPTAKPKAPKPKKAAAPKAAKAPARKAPSPLAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HFJ3</accession>
    <name>A0A8J2HFJ3_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Similar to ZNF764: Zinc finger protein 764 (Homo sapiens)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HICCMSTLAB_LOCUS8911</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5097855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HFJ3"/>
    <dbReference type="OrthoDB" id="10004641at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050888">
        <property type="entry name" value="ZnF_C2H2-type_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24406">
        <property type="entry name" value="TRANSCRIPTIONAL REPRESSOR CTCFL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13909">
        <property type="entry name" value="zf-H2C2_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="28"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="105"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="134"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAG5097855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="175" mass="20581" checksum="CBC5C6385AC8B006" modified="2022-05-25" version="1">MYNKKISEEILIKKNPQNLEDKLEEEKFTCQFCEKKYEKYNSLVQHRSKYCLKNPKACRNTRIFQCPNCSYLTAFVSNMSRHIRTQHAVAGSAASWAQKDSSDRYSCPKCSRSYKNFGDMRKHLRFMCGQAPRFLCPYCNRCSNNSSNMYVHVRRAHKGRDVFLIDAYDSSRHTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HH22</accession>
    <name>A0A8J2HH22_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Galactose mutarotase</fullName>
            <ecNumber evidence="5">5.1.3.15</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Aldose 1-epimerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HICCMSTLAB_LOCUS10113</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Mutarotase that catalyzes the interconversion of beta-D-galactose and alpha-D-galactose during galactose metabolism. Beta-D-galactose is metabolized in the liver into glucose 1-phosphate, the primary metabolic fuel, by the action of four enzymes that constitute the Leloir pathway: GALM, GALK1 (galactokinase), GALT (galactose-1-phosphate uridylyltransferase) and GALE (UDP-galactose-4'-epimerase). Involved in the maintenance of the equilibrium between the beta- and alpha-anomers of galactose, therefore ensuring a sufficient supply of the alpha-anomer for GALK1. Also active on D-glucose although shows a preference for galactose over glucose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>alpha-D-galactose = beta-D-galactose</text>
            <dbReference type="Rhea" id="RHEA:28675"/>
            <dbReference type="ChEBI" id="CHEBI:27667"/>
            <dbReference type="ChEBI" id="CHEBI:28061"/>
            <dbReference type="EC" id="5.1.3.3"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="2">
            <dbReference type="Rhea" id="RHEA:28677"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>alpha-D-glucose 6-phosphate = beta-D-glucose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:16249"/>
            <dbReference type="ChEBI" id="CHEBI:58225"/>
            <dbReference type="ChEBI" id="CHEBI:58247"/>
            <dbReference type="EC" id="5.1.3.15"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Carbohydrate metabolism; galactose metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the glucose-6-phosphate 1-epimerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.1.3.15" evidence="5"/>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5101040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HH22"/>
    <dbReference type="OrthoDB" id="1659429at2759"/>
    <dbReference type="UniPathway" id="UPA00214"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004034">
        <property type="term" value="F:aldose 1-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047938">
        <property type="term" value="F:glucose-6-phosphate 1-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006012">
        <property type="term" value="P:galactose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd09020">
        <property type="entry name" value="D-hex-6-P-epi_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008183">
        <property type="entry name" value="Aldose_1/G6P_1-epimerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025532">
        <property type="entry name" value="G6P_1-epimerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11122">
        <property type="entry name" value="APOSPORY-ASSOCIATED PROTEIN C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11122:SF13">
        <property type="entry name" value="GLUCOSE-6-PHOSPHATE 1-EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01263">
        <property type="entry name" value="Aldose_epim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="362"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="370"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00021023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00045743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAG5101040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="401" mass="45396" checksum="E11D4CE1FB7277D3" modified="2022-05-25" version="1">MRRAGELDGTRYSPDQHQQVLVVHQIPQSGGVICDIMAAATSVVVLDRGNNTTCTINLHGATVVSWRVNNQEQLFVSKQAVFDGKKAIRGGIPFVFPQFGAWSFGPGHGFARIIRWNVEKSPERLPSGDVEAIFSIMDNEFTRSMWNYPFRLTYRLILREKELHFNIGVYNPSKEHTFSFNLLLHTYFKVPDVRRCQITGLHGCTFIDKTRDNQIFQEGLDVVTVREWTDRIYQNTQPEHIITNVVSGRKMRVQKYNFPDTVIWNPWQEKARDIPDFGDDEFPNMICVESGHVSSPVILLPGTAFEASQILQGGVSSSQVPSNNVVTSDHFLPASGTLSPARPRATVGWPASPPNWLYVQSPMQTPTTPNHHHHHHHHHHHPSHHYANCITQSCSICSLNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HHR1</accession>
    <name>A0A8J2HHR1_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS5659</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5090504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HHR1"/>
    <dbReference type="OrthoDB" id="8197271at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="500"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="632"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="643"/>
            <end position="656"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5090504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="694" mass="77735" checksum="46258290F955E01E" modified="2022-05-25" version="1">MVPLHSNKMFRLISICIFSILVNLVIAKIPPSFSLWKEPAKNAVYSRSLGSPPVPGIDTINIPYVPKPLFFPKFVDPKVMIAQKTELLKNLFGGLGPVNYPITDPSDDSLTFEKTKPFLYATSNEIEPLGDTGKLENILENDKKEADNVKRGIFGSKFGSFGPVNSKFFRSSPKFLSGLSYSYPETEFNDFDSTNSLARHKRSIMSPMTNVPTDQGEFSPYPEVDPIFQYPEYYNYSAPQPYFPSVLGPFGSYPGYGPFYATPMIDPASMFTAKKTAFLNQFFKSLGPSAANPETDMPYNNPESFWSPSINAEVTTEIPVPKSTIVPPGFWAPSSIVPAPGEYTTKVSFFLDKLFKSIANKTAAKAAASSKISPSIMARSINDLLNDPSNRVARSIDDVQTLSIAKDAIVDSIIAELGSLKTDMLNNFDDFTIAQQLSTASIGKNSAKPFKTGFSGLYKSTSTDFSLPYKQKMMVLSKVFDSLTELHKNISSAVSDAIKSNMDEESDKSDKYSEQKSMFNETSADTVQNKVMKMNSPMAYQDPSLFYQAFSPSYQQPFPFYQPPTPVQPTEPFWMAFVKAKSTTPKPKKIKGTKREVESDFENYYPSEDYDNEDENKREEYKRAVKMSMRQGLPPGTVENIQAGGGSKSGHQGGGMNLFNRHNYEDNYPDWKKWSDWADNYHSSYRDHQHKHHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HIH1</accession>
    <name>A0A8J2HIH1_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS8405</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5096827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HIH1"/>
    <dbReference type="OrthoDB" id="7617398at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="124"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5096827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="193" mass="22991" checksum="25ED8F7ED93F827F" modified="2022-05-25" version="1">MNELEKRMEKLEGLAERRNQEGQAVFKEGELMVSKETEERVRSLEISVERQERKVRRKNIIVKGVEMQRNKEWSQEVERIWEKIGVEGGKRNMRKIGGIDKEGKSLVLIEMEGLEKKREVMMAKSKLKGEKVRIEDDLTREERRIQRLIMEEARKERENGKRVKVGYMKMWVNDELRLWNESGEGWKMEEGNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HJL6</accession>
    <name>A0A8J2HJL6_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">HTH psq-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS9702</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5100629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HJL6"/>
    <dbReference type="OrthoDB" id="4327074at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="313"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5100629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="520" mass="59283" checksum="70046C3523BD4AD6" modified="2022-05-25" version="1">MKFNLFVLENRPAKHGDKKIISVCAIGRFTMVKTKKKEAQRFKYTVPQLKSAVAEIKQGKSVRAISKKYSIPRSTLNSKVKETSPKIKKGGPETVLTRDEEQHLISWMMLMSENGFPVSKTQLLGSVKMLLSTLANKNREHPFKDGVPGQRIAQNLTISRAAISESGIRRWFSEVKEELVLKSLLEIDGNRVFNGDESAFMLDPKKNFTTLLKSAVDTLDIRSIMKNAFKTTGLHPFSADAINYNKLRNKTKGNEEQDNASPQSEDHHALTAMEKYIDPVTLRKFEEVDDDEEWDGDLKDSSLFMVWKSMKMIGSKVLFLLFFFLFFLLFVSVENRFLVCSIASTSAQDLDTDGVLLRSNNDNIDFEFLDELTPQQASENAMQIAIDNDLIIIEAENLHDEPDNEIRIQIEDNPTEEQTVLENIHVQNSLSIEDSRIEENNETLSGNIETSLVEEQQLIVQNKENSTDNFVNKGFNVNENFPLSFREALFWPDKATDKKKRKENLRIKSLLLFLHCNGST</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HKG0</accession>
    <name>A0A8J2HKG0_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Similar to Flvcr2: Feline leukemia virus subgroup C receptor-related protein 2 (Mus musculus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HICCMSTLAB_LOCUS7412</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5094086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HKG0"/>
    <dbReference type="OrthoDB" id="422206at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015232">
        <property type="term" value="F:heme transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097037">
        <property type="term" value="P:heme export"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049680">
        <property type="entry name" value="FLVCR1-2_SLC49-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10924:SF4">
        <property type="entry name" value="GH15861P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10924">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="29"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="59"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="92"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="125"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="158"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="197"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="255"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="294"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="325"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="349"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="386"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="412"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="28"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAG5094086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="463" mass="51835" checksum="2E620C76B8064A9F" modified="2022-05-25" version="1">MMEEKISSQDDNRGGNGDEINIKEYKKRWIMLGLFTIYTGLSTFQWVEYSIISNIISRYYNVSSLAVDMTSMTYMFYYVILVVPGSYMAERIGLRWTAILGSSFVCIGSWIKIFSVSPNGFITTFIGQSFLAVTQVVILTVPGRLAALWFPSRQISTATSLGIFGNQLGVALGFWLTPILVKNHEKLEDIGADLLKLFWTVAALSTASFILVVIFFQDEPKLPPSQTRKLQKINNSENKSGLIKPIKRLMTNKSYLILCNSYGLGVGVLNVVGTLLNQMFLIHFKNGEEDAGRLGLLIIVMGMFGSVIFGFILDKTHKFKETTVTVYFLTLLGQILFAIAMWIEIKWTVYLAATFLGFFLSGYLALGYEMCAEYTYPESESIATGILNIANNIYGIILVIISGKLMETNGDLAVHICLCVSLLFGFIMTVLTKDEQKRQDAQKKVYINVSSTDRDIPINNHPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HKS6</accession>
    <name>A0A8J2HKS6_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Olfactory receptor 137</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HICCMSTLAB_LOCUS12254</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5106426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HKS6"/>
    <dbReference type="OrthoDB" id="7696577at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005549">
        <property type="term" value="F:odorant binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004984">
        <property type="term" value="F:olfactory receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004117">
        <property type="entry name" value="7tm6_olfct_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21137">
        <property type="entry name" value="ODORANT RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21137:SF35">
        <property type="entry name" value="ODORANT RECEPTOR 19A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02949">
        <property type="entry name" value="7tm_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0552">Olfaction</keyword>
    <keyword evidence="8 11" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="9" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="32"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="129"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="174"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="261"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAG5106426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="370" mass="42965" checksum="18D25BE44965F667" modified="2022-05-25" version="1" fragment="single">MDYLASSYCRLNKDLLSCLGEWPYQTSTQRRLVRSIIYFLSASIIIPKIIKLIKVWGNLDLIIECVPMLLLDAVNFVKVANGFMNFHKMRQLFDRIQDDWKLEFTKKEFEILENYAEDGRKLTKFYATYMYSTMLIYFCMPILPKILDVLAPLNASRPELYLFEAEYFIDQHKYYFPILIHAYITCAVAVSILVAFDTEYVVQVLHGCGIFAHMVIRDDEANLKNDKQIKATTYKMVVDCAILHRRALDFADLLESSRVTYFFFVLFVNIAAISITGVQTVLKLDQPTEAVRFGVYTLAQVTHIFYSSYPAQMLYDNSWQMSDAIFAGNWYRAGRNSKNLLHMMIIRSRKPCKLTAGKIYLMSLENFSAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HKZ5</accession>
    <name>A0A8J2HKZ5_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Similar to prom1a: Prominin-1-A (Danio rerio)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HICCMSTLAB_LOCUS9800</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the prominin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5100727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HKZ5"/>
    <dbReference type="OrthoDB" id="6229420at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008795">
        <property type="entry name" value="Prominin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22730">
        <property type="entry name" value="PROMININ PROM PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22730:SF1">
        <property type="entry name" value="PROMININ-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05478">
        <property type="entry name" value="Prominin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="35"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="79"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="351"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="397"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG5100727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="514" mass="57789" checksum="28E0D79CC1F83AA6" modified="2022-05-25" version="1">MHLRLITVKNGWLEFADPVKQWKILVTHYGGLGGLAIIGIIFAAIIPCIGLFFCCCRCAGHCGARSQPFDKKYDHCRKVFLNILLIGVSTIILFGVVCAFVTNEYMQEGIENLPSRAKTNLKDVELYLTTTKKQISTLLTTNYNELEITLNNILQASGKIVTEELAAYSHAVSLTNLNEIVSGLDTIRQDLRMIDKLTRDLRTNASQLDIVVRGVKKNLLETLTGCKNHECQQVLHDYKINQMSIQVDFDKLPDVTLALRNITSLMEGNIVSEVSQGRETFLKIQRNIQQAVNETIPVVSASIENAGRSLASASKNITSLIDKINKEITKVYIPHLKIAQDNIEEYSIYRYYFGLGVSSVLLAIFTLLTFGLLCGICGKRPDGFGDDCCNKGTGGRFLMIAVWIIFLLTSILIVITTVLMIIGVMSHRTICEPLQNPKDNHIFELVDELVQVKQLLYPNNLEADINLSWIVTHCHKNETLYNVLKLKYLMELDSLKNFVDRYAISSTIDLEFEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HL41</accession>
    <name>A0A8J2HL41_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">GPI ethanolamine phosphate transferase 1</fullName>
            <ecNumber evidence="12">2.-.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">HICCMSTLAB_LOCUS12480</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Ethanolamine phosphate transferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers ethanolamine phosphate to the first alpha-1,4-linked mannose of the glycosylphosphatidylinositol precursor of GPI-anchor.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 12">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Endoplasmic reticulum membrane</location>
            <topology evidence="1 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the PIGG/PIGN/PIGO family. PIGN subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.-.-.-" evidence="12"/>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5106878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HL41"/>
    <dbReference type="OrthoDB" id="2748310at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051377">
        <property type="term" value="F:mannose-ethanolamine phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd16020">
        <property type="entry name" value="GPI_EPT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007070">
        <property type="entry name" value="GPI_EtnP_transferase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017852">
        <property type="entry name" value="GPI_EtnP_transferase_1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002591">
        <property type="entry name" value="Phosphodiest/P_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037671">
        <property type="entry name" value="PIGN_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12250:SF0">
        <property type="entry name" value="GPI ETHANOLAMINE PHOSPHATE TRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12250">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL GLYCAN, CLASS N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01663">
        <property type="entry name" value="Phosphodiest"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04987">
        <property type="entry name" value="PigN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 12" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="408"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="449"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="482"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="512"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="535"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="665"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="697"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="729"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="761"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="domain" description="GPI ethanolamine phosphate transferase 1 C-terminal" evidence="13">
        <location>
            <begin position="456"/>
            <end position="753"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU367138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF04987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CAG5106878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="800" mass="89139" checksum="CD01C46FF25E56E5" modified="2022-05-25" version="1">MTGHKQSTEGYLFGICGLIVHLVILWGVLDANFYSPVLNDLPVVEPLSGAPAKRLFLFVADGMRYRTFSSEPAPFLKNIIKTQGTWGVSHTRMPTESRPGNVAIAAGLYEDPSALFKGWKENPVDFDSVFNQRSHLNVRGDSYPAEWQDFDKASNSPITLDSWVFKKYFEWLDRDAIKIKSRKGVLLFFHLLGCDTAGHASKPHSKYTMLCFGFREYKESLKFVDQKIKEVVKSVDKFFGDSRTAYIFTADHGMTDWGSHGSGSDDETETPFIAWGAGVSHLSGRRDIEQADIAPLVASLLGISIPVNSEGVLPRLYLQSGNQEYGARALLNNIKQLLNQVKGNRLTASGEGSSYSNWRERELEKMIDKVEKLLHDNKVVEAIRVAEETIEKCKSYLYYYRQYQKNQLIVYLTLMWLGWIVLLVLKITGTPRSHLNNTYKVKSRKDSRVIYYGIAALIFVWLGFCAPLVLVPVYHVKKNEPIRIIIGGTVLFLAMVITAIMQKLTIKKPDKLLILTALALAIYPALPTVKPDPQTGIVLISVAVAAVALVIHNLPSHILIIELLRLALTTLILTGDIDGRTGLSWIILASSPISIFLHPADDVKKRLTGVTYGLFCPLVLLSASYEPQVYLLLAIHLMTLLDNDNNDEELKSTGHCRRSLSPSDLMLYILLSFFGTGNMASISSFDPMWTKHFITLFSPFTMSALILLKLAIPLILVGCASRVLASSSIFLAVLLLGDCLSLPLIFTVTPQGSWLDIGTAISRYAIAVTLPCLFLVLYHLSSPLMTVDFSSRKTLKKHLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HLQ7</accession>
    <name>A0A8J2HLQ7_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to Transposon TX1 uncharacterized 82 kDa protein (Xenopus laevis)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS11182</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5102784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HLQ7"/>
    <dbReference type="OrthoDB" id="7701518at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CCHC-type" evidence="2">
        <location>
            <begin position="59"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="73"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="165"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5102784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="176" mass="19674" checksum="85FE59D7C7B2C217" modified="2022-05-25" version="1">MSNITTLRAGLNNAGYQHILSFRRQLYIKPEDVKKLSTSWKVDFDETSYWIYPTMDNMLCYVCKEEGHLAKSCPTDSNLKNSQNPEENNLLTASQTSCNEQSLSPAPVDNNNSNKEQTKFPSLPAKRPLSSTSSTAGMPPPATPLGKRSENLKDNLATKQKSKKIRTEDGQLHQNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HLX0</accession>
    <name>A0A8J2HLX0_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">HICCMSTLAB_LOCUS10221</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the ECSIT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5101148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HLX0"/>
    <dbReference type="OrthoDB" id="10064298at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007178">
        <property type="term" value="P:cell surface receptor protein serine/threonine kinase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045087">
        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029342">
        <property type="entry name" value="ECIST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010418">
        <property type="entry name" value="ECSIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046448">
        <property type="entry name" value="ECSIT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13113">
        <property type="entry name" value="ECSIT EVOLUTIONARILY CONSERVED SIGNALING INTERMEDIATE IN TOLL PATHWAYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13113:SF1">
        <property type="entry name" value="EVOLUTIONARILY CONSERVED SIGNALING INTERMEDIATE IN TOLL PATHWAY, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14784">
        <property type="entry name" value="ECSIT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06239">
        <property type="entry name" value="ECSIT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01284">
        <property type="entry name" value="ECSIT_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0391">Immunity</keyword>
    <keyword evidence="7" id="KW-0399">Innate immunity</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="ECSIT C-terminal" evidence="13">
        <location>
            <begin position="249"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="377"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM01284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CAG5101148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="399" mass="45954" checksum="A1A38612A016CA87" modified="2022-05-25" version="1">MLIRRISTMKFSSSLRLVTKNTRVSRSFKQPSAVIRFIHTSINNFSVNVEEKEKKIALFDAANIKSKKEKSTFLAVLHAYIKEGERKTGHVQFVYAALRYMKEFGVADDLEVYKAVLDTLPKGRFVAKTWFQADMFHYPREQQCAIDLLQQMEDNGVMPDPETELMVINIFGQHGLPLRKLRRMAYWQGKFKNLNPWPYPRPLPTDNFQLAMLAIKKVSSVDVQTTITVFDTEEVKDSIDKTWIISASSPDQERLISKHPPNQPAYVEGPFRIWVWKVSVDYFLLHTDPKERIVEDIDIDDVSNLDINLWKRSKRALALHRSIHEQDEQTILGICATGTSTKDSLLSWIRCLQPRNPALEKIPILFKFTSIVNDNEKVEPAPERKKVSDGDTDESKLGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HLX4</accession>
    <name>A0A8J2HLX4_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS12365</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5106649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HLX4"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5106649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="137" mass="15595" checksum="AF6BE48979BC046A" modified="2022-05-25" version="1">MGIDTFGTGKLSSKVPTSLGLRGHFWAFPTRLSHPLMFKFLYSTQNLNNLNLATGFNVEVPLSVNVVSGVNWTRKIITVLDVQIFWFRCTFTDNKVIILLEHLDVLIKLKIILSKLTTHFSKRAFLQIFRSTNLVSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HM25</accession>
    <name>A0A8J2HM25_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Small nuclear ribonucleoprotein-associated protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">HICCMSTLAB_LOCUS8592</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the snRNP SmB/SmN family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5097207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HM25"/>
    <dbReference type="OrthoDB" id="2020720at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071004">
        <property type="term" value="C:U2-type prespliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005687">
        <property type="term" value="C:U4 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070990">
        <property type="term" value="F:snRNP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01717">
        <property type="entry name" value="Sm_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000004">
        <property type="entry name" value="Small nuclear ribonucleoprotein-associated proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017131">
        <property type="entry name" value="snRNP-assoc_SmB/SmN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050914">
        <property type="entry name" value="snRNP_SmB/NAA38-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10701:SF0">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN-ASSOCIATED PROTEIN B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10701">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN-ASSOCIATED PROTEIN B AND N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037187">
        <property type="entry name" value="snRNP_SmB/SmN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="9 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="10 11 14" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="7 11" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Sm" evidence="13">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="134"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="145"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="187"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR037187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CAG5097207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="210" mass="21917" checksum="DAEC4607FDBBDF60" modified="2022-05-25" version="1">MLQHINYRVRIILQDSRTFIGTFKAFDKHMNLILGDCEEFCKIKPKNTKQPEREKKRVLGFVLLRGENIVSLTVEGPPPPEEGLPRVPIPGAAPGPGMGRAVGRGMPANVAGVPAGLQGPVRGVGGPSQQIMTPAGRGQVSAPPQMHPGAPPRMPVSGPPPGMMGPPPGMMGMPPGMPPGMGRGGPPIGPPGMRGPPPGMMRGGPPPRPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HMJ3</accession>
    <name>A0A8J2HMJ3_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Similar to PSMB7: Proteasome subunit beta type-7 (Homo sapiens)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HICCMSTLAB_LOCUS11050</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subunit">
        <text evidence="5">The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5102508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HMJ3"/>
    <dbReference type="OrthoDB" id="429533at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005839">
        <property type="term" value="C:proteasome core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004298">
        <property type="term" value="F:threonine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024689">
        <property type="entry name" value="Proteasome_bsu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023333">
        <property type="entry name" value="Proteasome_suB-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194">
        <property type="entry name" value="METALLOPROTEASE TLDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194:SF4">
        <property type="entry name" value="PROTEASOME SUBUNIT BETA TYPE-7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12465">
        <property type="entry name" value="Pr_beta_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-0647">Proteasome</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0888">Threonine protease</keyword>
    <feature type="domain" description="Proteasome beta subunit C-terminal" evidence="6">
        <location>
            <begin position="184"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00026071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF12465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAG5102508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="230" mass="25288" checksum="D9DCFD73F18BFD01" modified="2022-05-25" version="1">MSSVLLPEVPAPGFSFDLCKRNELLASKGYAAPKAQKTEMIASQLELHRLNTGRVPRVVTANRMLKQHLFRHQGHIGAALVLGGVDIDGPHLYAIFPHGSSENYMFTTMGSGSLAAMAVFESRWKPGLTEEEGKELVADAIRAGVFNDLGSGSNVDVCVIRNNQVRGPVFDSRSVDYIRPYDVANEKGKRQGSYRYKRGTTAVLDKSVRPIVIEHEAVRKIELESMDTSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HMX0</accession>
    <name>A0A8J2HMX0_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to l(2)gd1: Coiled-coil and C2 domain-containing protein 1-like (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS9184</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5099687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HMX0"/>
    <dbReference type="OrthoDB" id="19996at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001227">
        <property type="term" value="F:DNA-binding transcription repressor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039725">
        <property type="entry name" value="CC2D1A/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006608">
        <property type="entry name" value="CC2D1A/B_DM14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13076">
        <property type="entry name" value="COILED-COIL AND C2 DOMAIN-CONTAINING PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13076:SF9">
        <property type="entry name" value="COILED-COIL AND C2 DOMAIN-CONTAINING PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21528">
        <property type="entry name" value="CC2D1A-B_DM14"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00685">
        <property type="entry name" value="DM14"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DM14" evidence="2">
        <location>
            <begin position="130"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="DM14" evidence="2">
        <location>
            <begin position="242"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="DM14" evidence="2">
        <location>
            <begin position="353"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="domain" description="DM14" evidence="2">
        <location>
            <begin position="475"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="289"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="424"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="111"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="128"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="219"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="313"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="424"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="441"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5099687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="641" mass="70370" checksum="ACEB3DC37DA4252F" modified="2022-05-25" version="1">MFGRKKEQKKERKPRTNNPLGIDFMGGFDPMGIPDDDEDDEDLESELNRLAMGDDPRPRRPAPKPPAELIDLNFEVKEIGSDEELSGDDDDPDLLNELEALKNEDDSPNLEEVSSTPSSPAESPGSEELVKLLEERLNLYKQAELKSKSTNDTSKARRYNRGVKTLQGMLRDAKAGKNVESADIPPLLPRSATQMTPDTPADQESDTQEIPLENSTQPEPTPEIPPEAPPTAEPIPVDEEKLALLKKRQHEYKIAAVAWKKSGQVEEAVKYLKIAVRFDAVISALTSGEPVDLSDMPPTPDLPNNNNNNNNNSSTVTSTEVNLPQEPAKEESEVQDSVEEPPAPTPVTGGDIMGALKERLEVYRRTKTAAEEEGNSSKVRRYGRICKQYEDAIKLHSKGKSIPVDELPVPPGFPPIVLNVAAPKPAPAPAPKPAPAPGPGPKTSSENSGTGSEERPTAPARGKPMTSRAQKQTMILQKRQIELKRAALAAKKEGDLDLAKDYLRQAKQIEPLIQASMSGLPVDLASVPLSPVSKEELHNSIAASSNDSFALMSSDDCQPSEATGTDQEIYDNLEKQLVKHRKVCLATRDHAKALGDVPGYNRWENMALGYSRDLDMLRVRRRDGLPPPQHHYEVKTYAIVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HN07</accession>
    <name>A0A8J2HN07_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similar to CCDC51: Mitochondrial potassium channel (Homo sapiens)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS11744</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5103907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HN07"/>
    <dbReference type="OrthoDB" id="6243211at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034220">
        <property type="term" value="P:monoatomic ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037660">
        <property type="entry name" value="CCDC51"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28624">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28624:SF1">
        <property type="entry name" value="MITOCHONDRIAL POTASSIUM CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0407">Ion channel</keyword>
    <keyword evidence="2" id="KW-0406">Ion transport</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="201"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="295"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5103907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="314" mass="35926" checksum="9746275D54F21787" modified="2022-05-25" version="1">MTSRSKKLLDVITSRFYKSPVLTSAIESATERAHMQLTNFQNIANKKYDTIIRQVNGATIIQDLKSGALEPTPMPKQLVIWWKWYQQLTGLEDVELARQQMIAVQDKLFDCQNRRRVLNNQASLIADNLKQVYGELIQTKREDPKYVQLTIMENKALQEQGRIISQLNLLENEERDHFTQLATAIKEYHDSQNINAQKYKYLSILASAIIAILSLGGSMIYNNKRISDVHKIIAEGQTKNENMFKNYFAILEDSIEKINSQKVVADSIKPLNNSQINLPSVEIVEPAVNYDINKTVVIGSALALFFIIFNRLYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HN15</accession>
    <name>A0A8J2HN15_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Similar to SLC35C2: Solute carrier family 35 member C2 (Homo sapiens)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HICCMSTLAB_LOCUS11759</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5103937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HN15"/>
    <dbReference type="OrthoDB" id="18894at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004853">
        <property type="entry name" value="Sugar_P_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050186">
        <property type="entry name" value="TPT_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11132">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03151">
        <property type="entry name" value="TPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035280944" evidence="6">
        <location>
            <begin position="20"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="54"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="89"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="113"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="152"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="190"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="221"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="247"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="Sugar phosphate transporter" evidence="7">
        <location>
            <begin position="20"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG5103937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="345" mass="38987" checksum="881E9842DD9F6591" modified="2022-05-25" version="1">MCHLLVKLFLSAFIRNVKSYKRGQQQVRLSWQSILSALAPPGIASGLDVGFSNWALSIISLSLYTMTKSTSIIFILGFSLVFNLEKKSWSLVGVVIMISSGLIMFTYKSTQFVVAGFILCLLASFASGLRWTMAQLIMQKSKLGIKSPIDMMYYMQSWMLLAIFPMALWFESQEMFYNIQKIDWSQPHQVLWTITAVFIGAILAFNMEVMEFMVVTYTSSLTLAILGILKEICILVLAFAFKGDQISRINFFGLLLCLGGIVLHVMQKILTNKKEIQENLELHSNSMTTVGSVEEDMDTNMPLLTERSTSLTNLLNSNFSTDDDDDKDKDDSSEVLFNILQRREP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HP23</accession>
    <name>A0A8J2HP23_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Similar to AVT1C: Amino acid transporter AVT1C (Arabidopsis thaliana)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HICCMSTLAB_LOCUS12651</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5107242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HP23"/>
    <dbReference type="OrthoDB" id="28208at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF703">
        <property type="entry name" value="AMINO ACID TRANSPORTER TRANSMEMBRANE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="17"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="45"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="104"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="144"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="169"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="243"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="286"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="345"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="511"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="7">
        <location>
            <begin position="28"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="433"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="435"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG5107242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="557" mass="62199" checksum="509EA2F25812AB53" modified="2022-05-25" version="1">MNTERTSLLNSDLNSGLSIFFATLCIIDIFGVFPIIALPHAIIHCGLLGISLVIVVFFLQIYTASLLGKSWTIATTLDPQILRKNRHPLAAVTEMTLGKKMRTFVTLLLDLTIFGCGIPNLLVASQNLQLFGFKVSDNQFNLSFCYWLLVVGIFLCPLMWLGSPRDMKPLAIFSTIAVTMTTVLVWWCIIADDRALEPAPIPTSPTWDKFISGYSMLAFQFDVHPTLMTIQVDMRHPQHINKAVVLSFLISGLLFGVTAGLAAWKYAGSTTANILQIAPAGHVSRAAILLSALQLIFSSVIGHAALFLHLEDELRVRRTFGWKRCALRSAVVFLGVAVGESVPRFDIVMSLIGGTLTGPLVFILPPIMYARARTMKNEFDKYSSTSEVFSATERQSDDDLIVDETRAHSKSTYFGIPENKKNRQRYTYVYYSDNDVNDNDDDSEGLLSDVDDQRSKKKLQPHTMTAERNKSATGFIDATKPEKFRSKTRLQPLIIKSKTKDKRYKIIFKRLTNLFSYFVVVMGVVITISATYINVKNTIRFVKFTPPCIINASVSAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HP67</accession>
    <name>A0A8J2HP67_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Similar to Cubn: Cubilin (Rattus norvegicus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HICCMSTLAB_LOCUS11001</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5102410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HP67"/>
    <dbReference type="OrthoDB" id="6431754at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00041">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.290">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000859">
        <property type="entry name" value="CUB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035914">
        <property type="entry name" value="Sperma_CUB_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24251">
        <property type="entry name" value="OVOCHYMASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00431">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00042">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49854">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01180">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="368"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="5">
        <location>
            <begin position="41"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAG5102410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="417" mass="45870" checksum="433461D0CA142F33" modified="2022-05-25" version="1">MATLKARSEMNLLGGMESESMANNKKKIKIKIRKNAVNKYCNMKVTIDDNQGGYVKSPGYPLYYPGQFACNWTFHTVPGHRVSLVFHDFNIRSPEPNGSCLDSVRIRENGRILFDSCGTRAGVKIISHSNKITVDLISSSRVYPGRGFLLHYEAIRSCPETTAPKGSYVTNDTLDSRTFKCFSGTIFPDTKEPTRTLDCPEPNGSCLDSVRIRENGRILFDSCGTRAGVKIISHSNKITVDLISSSRVYPGRGFLLHYEAIRSCPETTAPKGSYVTNDTLDSRTFKCFSGTIFPDTKEPTRTLDSSSAAILKTESDSNHLSSLSDSNIQSTGVRIGRIENAVAVGSNFDMADPAQSAMSKKGDFVIDMVVPSILIVLLFVGNAVIVYIIFQYRKRKTPAINSGEGMALRPAQEVPQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HPJ6</accession>
    <name>A0A8J2HPJ6_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similar to JKAMP: JNK1/MAPK8-associated membrane protein (Homo sapiens)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS12457</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5106832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HPJ6"/>
    <dbReference type="OrthoDB" id="5920264at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006986">
        <property type="term" value="P:response to unfolded protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008485">
        <property type="entry name" value="JAMP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12740">
        <property type="entry name" value="JNK1/MAPK8-ASSOCIATED MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12740:SF4">
        <property type="entry name" value="JNK1_MAPK8-ASSOCIATED MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05571">
        <property type="entry name" value="JAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="147"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="182"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="206"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="247"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="272"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5106832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="302" mass="34254" checksum="24D4AAF9E8B3E1A1" modified="2022-05-25" version="1">MNFVERCPGMYCGRELLSDGNWTDCGACPRGFRTNSSSACVPCDEMPIFYDWLYLGFMALLALVLHWFCIDMVALRRNIPKEVIVIHLSALLEIVCASLITLQVTNPVGSFEIRSCRARKLSDWYTLLHNPSPNYENSLHCTQEAVYPLYTMVFIFYSLSVTIMILIRPLIVRKFLPKQGKYSIYAALYFFPILALLHAVGGGLIYYSFPYITIILSVLSNAAHFAFKLNQTMKSLLFSSISDVRNVIVILGHWLLHGYGIMAVATLRSVNIHPTMLLLVPLPALFYIITARFTDPHKLHAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HPT9</accession>
    <name>A0A8J2HPT9_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to Slc8a2: Sodium/calcium exchanger 2 (Mus musculus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS12127</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5106171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HPT9"/>
    <dbReference type="OrthoDB" id="418484at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098794">
        <property type="term" value="C:postsynapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042383">
        <property type="term" value="C:sarcolemma"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005432">
        <property type="term" value="F:calcium:sodium antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098703">
        <property type="term" value="P:calcium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2030">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051171">
        <property type="entry name" value="CaCA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038081">
        <property type="entry name" value="CalX-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11878:SF65">
        <property type="entry name" value="NA_CA-EXCHANGE PROTEIN, ISOFORM G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11878">
        <property type="entry name" value="SODIUM/CALCIUM EXCHANGER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0406">Ion transport</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5106171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="302" mass="33555" checksum="1B991FF3D3E2D8E8" modified="2022-05-25" version="1">MRLSISNIITLKVNSWCRLQRVIRSRKHAGHTPRTRGSIIVFRFVLYSVLCFLLTIGDSNWRSKSKSRAFCYLEPIRGTEAGLAAAAELKPPEERTKEERMAIMGKPKLGENKVAQVRIKESKEFKNTVDKLVQRANASIILGTSSWKEQFTEALTVSGGDDDDDAEADAEGRVSTPSTADYLMHSLTIFWKVLFAFVPPTKFILCGELNSVNPKDANGCDINPAGEKEGEMLGAVTDGNSHVVVVLLCVVVGELEALKSPGNRGSYCLLNDPLRAPLATVVWFNIQSDYQPRNRMHTEERL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HPW0</accession>
    <name>A0A8J2HPW0_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HICCMSTLAB_LOCUS12699</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the muscleblind family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5107338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HPW0"/>
    <dbReference type="OrthoDB" id="6285980at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054429">
        <property type="entry name" value="Znf-CCCH_Muscleblind-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22628">
        <property type="entry name" value="zf-CCCH_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="3">
        <location>
            <begin position="57"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="2">
        <location>
            <begin position="57"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG5107338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="99" mass="10509" checksum="C68ACECF04693839" modified="2022-05-25" version="1">MWIALAALATVGAHVVPQNAHCVVYTDSCGQLTISLIFRITPIPANLSVFGNVEVVDNRVTVCRDAVKGACMRPQCKYYHIPVALPPAPLMAISASSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HPY2</accession>
    <name>A0A8J2HPY2_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Protein artemis</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">DNA cross-link repair 1C protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">HICCMSTLAB_LOCUS10862</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DNA repair metallo-beta-lactamase (DRMBL) family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 16">Belongs to the EF-1-beta/EF-1-delta family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5102132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HPY2"/>
    <dbReference type="OrthoDB" id="262529at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035312">
        <property type="term" value="F:5'-3' DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036297">
        <property type="term" value="P:interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00292">
        <property type="entry name" value="EF1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.60:FF:000001">
        <property type="entry name" value="Elongation factor 1-beta 1 like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12650">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011084">
        <property type="entry name" value="DRMBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036219">
        <property type="entry name" value="eEF-1beta-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018940">
        <property type="entry name" value="EF-1_beta_acid_region_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014038">
        <property type="entry name" value="EF1B_bsu/dsu_GNE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014717">
        <property type="entry name" value="Transl_elong_EF1B/ribsomal_bS6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001326">
        <property type="entry name" value="Transl_elong_EF1B_B/D_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23240">
        <property type="entry name" value="DNA CROSS-LINK REPAIR PROTEIN PSO2/SNM1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23240:SF8">
        <property type="entry name" value="PROTEIN ARTEMIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07522">
        <property type="entry name" value="DRMBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10587">
        <property type="entry name" value="EF-1_beta_acid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00736">
        <property type="entry name" value="EF1_GNE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01182">
        <property type="entry name" value="EF-1_beta_acid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00888">
        <property type="entry name" value="EF1_GNE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54984">
        <property type="entry name" value="eEF-1beta-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00824">
        <property type="entry name" value="EF1BD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00825">
        <property type="entry name" value="EF1BD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="17" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="11" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="12" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7 16 21" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="5" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="9" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10 16" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Elongation factor 1 beta central acidic region eukaryote" evidence="20">
        <location>
            <begin position="603"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="domain" description="Translation elongation factor EF1B beta/delta subunit guanine nucleotide exchange" evidence="19">
        <location>
            <begin position="639"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="440"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="17">
        <location>
            <begin position="534"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="450"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00039759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00042677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU003791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="SMART" id="SM00888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="SMART" id="SM01182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="CAG5102132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="725" mass="82589" checksum="B22C3B87D1172E0D" modified="2022-05-25" version="1">MSTFGGLIEEIPGISVDRFDGENLKSSLFFLSHCHTDHMQGLIYQTDFVKKLLAQNQYLYCSPISKKILEYKLHRFGPEADFIKTIDGVSPIIVEYNVENKTEYLKVTSISAGHCPGSVMFLFEIKKISVLYTGDFRFDSKDLSKFKPLHDFVDGKMIPKKFDNIYLDTTFFNPNNDFFPSRQDCVREICKVASDWISKDNNNIVILECSAHYGPEYLFIELSNALKLRIHVKDKVYKSYTFFPELSKCVTDDPNATPIHACMEKNFRRFYVLQCRPKVKDESIITIIPSVWRWRYKDVKKNICEWEAINKRFYTCYSCHSSFSELKNFIEYFKPSKLYPCVVPINANFDDFKNTLNEILINSEEATNNFTGFNMKPLKFKPLDDAKKKTFKNFWINKSTYDAAERSHYERLYKVASRKILECNDSKKIITTKVQDFVPGNLPTKSSSKKSKENKNKADKKNKYLKNAENDVATDKKEVLNQESRVSGCSEDPARGSLANEVAKAREHIKKGLQCLNNISDDSTVPTQDLMGRLTLLEKDNRELHSTVKKLNKHIVDLEAAIKKLEVTVNGKGSAPEPHLAVCPAKPASAAAAAADDDDDLDLFGADSEGEDAEAAKIREERLAAYAAKKSKKPAVIAKSSIVLDVKPWDDETDMKEMEALVRKISCDGLLWGAAKLVPLAYKIHKLQISCVVEDDKVSVDWLTEEIEKHEDFVQSVDIAAFNKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HQ16</accession>
    <name>A0A8J2HQ16_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Elongator complex protein 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HICCMSTLAB_LOCUS13515</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="pathway">
        <text evidence="3">tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the ELP5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5108879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HQ16"/>
    <dbReference type="OrthoDB" id="166907at2759"/>
    <dbReference type="UniPathway" id="UPA00988"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033588">
        <property type="term" value="C:elongator holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002098">
        <property type="term" value="P:tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019519">
        <property type="entry name" value="Elp5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15641">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15641:SF1">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0819">tRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="272"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="279"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAG5108879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="292" mass="33540" checksum="3DE08D57BF4F70F3" modified="2022-05-25" version="1">MAKKLITSLPLMQDASFIVIDEDVEEPCADNLIDGWMQMWSTANLSQQINLLLFFNTKSHYNYLTTLFKDDKFHIHDYCLEDLDKIYEKQDFNEICERIMKSSIVDEKSIVVLNCLSSLIVNIGLARALRFVDKLSQRVSQLICIYRRDFGTQKIPKIETLGTTYVRLGKSSETAMNNEISYEVAMVHCKRGGGILKKHVVITQDPVSCEIKSENPVEFKAPVLVSQVVESSVKPQASFRIDMNARELEQRNQTPLPYMQVIKDATNESQIHYIPDKNDDFDEEDPDDDLPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HQE6</accession>
    <name>A0A8J2HQE6_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">40S ribosomal protein S25</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HICCMSTLAB_LOCUS12578</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Component of the small ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the small ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the eukaryotic ribosomal protein eS25 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5107085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HQE6"/>
    <dbReference type="OrthoDB" id="10263513at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022626">
        <property type="term" value="C:cytosolic ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000166">
        <property type="entry name" value="40S ribosomal protein S25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004977">
        <property type="entry name" value="Ribosomal_eS25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12850">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03297">
        <property type="entry name" value="Ribosomal_S25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6 8" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="54"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00045746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU366057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG5107085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="180" mass="20085" checksum="BB7D7DBDFEB9495B" modified="2022-05-25" version="1">MWKLSDINPRLLVHIPKISLLTINGDHSAPTAKIDTADSSFFLLQCIGHYAKKLKPPKKDTKGGSSKQPQKTQKKKEGGSGGKAKKKCLNELVKWSKGKVRDKLNNAVLFDKGTYDKLIKEVPQYKLITPSIVSERLKIRGSLARRALLELHQKGLIKQVVQHHAQLIYTRTTKGDDPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HR05</accession>
    <name>A0A8J2HR05_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">calcium/calmodulin-dependent protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">HICCMSTLAB_LOCUS11621</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.17"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.17"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.17" evidence="2"/>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5103661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HR05"/>
    <dbReference type="OrthoDB" id="68483at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004683">
        <property type="term" value="F:calcium/calmodulin-dependent protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000429">
        <property type="entry name" value="Calcium/calmodulin-dependent protein kinase kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF77">
        <property type="entry name" value="SERINE THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0112">Calmodulin-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 15" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="14">
        <location>
            <begin position="786"/>
            <end position="994"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="212"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="241"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="471"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="480"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="492"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="518"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="538"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="561"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="577"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="815"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CAG5103661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="994" mass="110601" checksum="66D9977BD10E3AE7" modified="2022-05-25" version="1">MNESTHVAIDEESPSSSSHLLATPLEVTKPSPPSTVVSTLLSVKEKLSSTIGSLESSCSPQKIAVEDSDNDNGVNLSRQADVPVGHKILEKQEYYQLRETYRQQSRSSLSAEAPEANWDTRKDSAVCLDDTELDELDELKERLLLQKVVPYDSIRNLSSDSTITSNSRLPPLPNNQRIPAVYASSCKNSEELNQLQKDSSVINHPTLAKYYRPRRESSGYSSNLSTFDEDRRNSTTIETLQGFSSAKDFQRERRRSSSAKRLNLNRLASTREREDESERMPTSEVIYRKVSTAGLIEMPNIKELKEIAEDVKCPSPDNDDDNDIVCLPGSKNQLDVKSKADGKESLSYIGIKKTSVYDKEYDSHLKGDADDMSEDDERDCIDTLNSVSERSDYKNIEEIRDRLGQTTLISCGDTDEKMSTAMLKDTRQSIVDKSLEVLSRTHDSGLIKSNLESCCREKDKKSEMELEKIVSGRDSLQPLKSDKKVDDKGRFRSISKVSSRSQSFNIADESLRKPLKGLTSSPNSSPKPTRHRSRIIHQYSSPLSSTMELESISERPLDDVSPSSCATQNLTVVVDNHDEDDGDDDDDDDDDGGGGGGDGDGLIAKRRANRIKKSQKRNETEELDTKKLFPRSVKVYQLLSTQSEDREDGEPRLMDRRTSLQITRHDIEEQAIPGTTLCIPDDKVLLHTESAPLIKYQPVQETSCLEAGSFNAARLSPVGKLASHPSGANQRLGDTGAVGIRPIYPYCPYSPYGSPQGSPRIRRRPLRESRRVSIDNKQGAFQLNQYKLLDNIGQGSFGIVKLAYNEEDETHYAMKILSKKKLMKKAGIFGRMAPGRKGVSNPLAKVYREIALLKKLDHPNVVKLVEVLDDPDEDNLYLVFELVQKGEVLELPTDKPLDEETARIHFRDVVLGVEYLHYQRIVHRDIKPSNLLVDSDGRVKIADLGVSAELRAPGELLSGSAGTPAFAAPETTVPGAQYSGTVSISLSITSIRVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HRD4</accession>
    <name>A0A8J2HRD4_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Tektin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HICCMSTLAB_LOCUS13216</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia and flagellar axoneme. Forms filamentous polymers in the walls of ciliary and flagellar microtubules.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
            <location evidence="10">Cytoskeleton</location>
            <location evidence="10">Cilium axoneme</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Flagellum axoneme</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the tektin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5108396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HRD4"/>
    <dbReference type="OrthoDB" id="10054259at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005930">
        <property type="term" value="C:axoneme"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015630">
        <property type="term" value="C:microtubule cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060294">
        <property type="term" value="P:cilium movement involved in cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048256">
        <property type="entry name" value="Tektin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000435">
        <property type="entry name" value="Tektins"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19960">
        <property type="entry name" value="TEKTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19960:SF25">
        <property type="entry name" value="TEKTIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03148">
        <property type="entry name" value="Tektin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00511">
        <property type="entry name" value="TEKTIN"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0966">Cell projection</keyword>
    <keyword evidence="6 10" id="KW-0969">Cilium</keyword>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4 10" id="KW-0282">Flagellum</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00045224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU367040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAG5108396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="354" mass="41595" checksum="1A88BF37E8263E78" modified="2022-05-25" version="1">MFTKKRLLKLNEPMEIVPPPTQKFTIDQWRLDNQARFRKCNIHCQLVESLIAESERICDSTLELTKTNKTATDYELKEKLTDVKFVKDEILRHRKDVILEIDALKTYKARLIDGLSSIQENAADICKKCLIAREHRLGIDLTVDDVEKELKKELEVISRADSIFTRTLEHTNEQIRILKSLLYYLDGDLENKDRSIQLDQRNLSLKETSLNLKWDLHTDEIVMSTMKQMNSTRVLRCYIDNILKEINITRLEKNIAEKEGFLALAHTRLGNRCHRPNLELTRDQVEQKLVQEVYDIRQTVAKLQQTLNEAHATLRYLLSMQIQLEEDINIKTNTLKIDEIECMTLRQSLNYHAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HS39</accession>
    <name>A0A8J2HS39_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Mothers against decapentaplegic homolog</fullName>
            <shortName evidence="7">MAD homolog</shortName>
            <shortName evidence="7">Mothers against DPP homolog</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">SMAD family member</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HICCMSTLAB_LOCUS12301</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the dwarfin/SMAD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5106521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HS39"/>
    <dbReference type="OrthoDB" id="5946219at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071144">
        <property type="term" value="C:heteromeric SMAD protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070411">
        <property type="term" value="F:I-SMAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140416">
        <property type="term" value="F:transcription regulator inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009653">
        <property type="term" value="P:anatomical structure morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009791">
        <property type="term" value="P:post-embryonic development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050793">
        <property type="term" value="P:regulation of developmental process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051239">
        <property type="term" value="P:regulation of multicellular organismal process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060395">
        <property type="term" value="P:SMAD protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10489">
        <property type="entry name" value="MH1_SMAD_6_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.520.10">
        <property type="entry name" value="SMAD MH1 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013790">
        <property type="entry name" value="Dwarfin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003619">
        <property type="entry name" value="MAD_homology1_Dwarfin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013019">
        <property type="entry name" value="MAD_homology_MH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017855">
        <property type="entry name" value="SMAD-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001132">
        <property type="entry name" value="SMAD_dom_Dwarfin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036578">
        <property type="entry name" value="SMAD_MH1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13703:SF54">
        <property type="entry name" value="MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13703">
        <property type="entry name" value="SMAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03165">
        <property type="entry name" value="MH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03166">
        <property type="entry name" value="MH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00523">
        <property type="entry name" value="DWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00524">
        <property type="entry name" value="DWB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56366">
        <property type="entry name" value="SMAD MH1 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51075">
        <property type="entry name" value="MH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51076">
        <property type="entry name" value="MH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="636"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="domain" description="MH1" evidence="10">
        <location>
            <begin position="263"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="domain" description="MH2" evidence="11">
        <location>
            <begin position="676"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="206"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="331"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="16"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="219"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="251"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="331"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="349"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAG5106521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="860" mass="95807" checksum="8CC0E7B19AC5ABC4" modified="2022-05-25" version="1">MRCQTTDSHDDEEDNAENKNAYKNEEENKKKRFISASVSIGGSGEATAGRSAEAIQLEVYRHSKTKTHFYFPIQETAAAAAAADAGVAVKRIKIGEKTNVYEDKKKFDSSLVPESIITHYFEHTTVGQRRCKVLAPKCTNVFSCFMFMFWSKRTILTKRLLKAQVCREYETECETQENTSQHIARVSNILAEASACSDTVVGGSGKTVSSLPGSRGTVPVSQPQAKRQTSSSGGGGSGPKIHQVCCGGADSQDESDEDDEEDNNEDELEDNKEDSLNDKIEREARERLNQCKELLKTLKENQLEMLLMAIESCGADLGSCVLVSRRPIHNSSSQLDITNGDQQPDPYRRRNSKRKSRHHHHPLRHRHSHRQFPRIRSRCRRCELHQGYNKDTQLLDESSSLALTGAAAGDDERCLTGENSRTDFLLTSSAAHLLSCQIWRWPDISLTSQLKKLPLCHSTKDPSYVCCNPYHWSRLCKPESPPPPYCLIPAKRGATKCEASSYAIQTNPADTRHCGNNIIVPSRLPESLTTDGEGKAIVLFRQRTYKSLDKLSSMVLGGQTKHDIVIRRSICLRKDHSDNYGTIFLQDIHDDDDDDDGGRRTGRVEPWAAVAHPDKPLLYFSLSFLFSVYPPLHYTYYRTIIIIIIIISIFIILRLYTLNLGLKILQRGDGHRRKEWCTLAYWELGGRVGRLYPVESSTISVFDSLHDGDGLCLASLAENHDSVDDAKTTRSKIGLGLVLSQEDDGVWAYNRSSNPIFVNSPTLDDPESRTLLVYRVPPGSCLNIFDRAKNLPSRCTYSNGNEGGGGGEGGISGAGGANSGGPVDMYSVRISFVKGWGPRYKRQEITSCPCWLEVLLAPCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HSN7</accession>
    <name>A0A8J2HSN7_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Similar to AP1M1: AP-1 complex subunit mu-1 (Homo sapiens)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HICCMSTLAB_LOCUS12830</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the trans-Golgi network (TGN) and endosomes. The AP complexes mediate the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle</location>
            <location evidence="1">Clathrin-coated vesicle membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the adaptor complexes medium subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5107611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HSN7"/>
    <dbReference type="OrthoDB" id="10259133at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030131">
        <property type="term" value="C:clathrin adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030665">
        <property type="term" value="C:clathrin-coated vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031984">
        <property type="term" value="C:organelle subcompartment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09258">
        <property type="entry name" value="AP-1_Mu1A_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14835">
        <property type="entry name" value="AP1_Mu_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1170:FF:000002">
        <property type="entry name" value="AP-1 complex subunit mu-1 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.60:FF:000006">
        <property type="entry name" value="AP-1 complex subunit mu-1 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1170">
        <property type="entry name" value="Mu homology domain, subdomain B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050431">
        <property type="entry name" value="Adaptor_comp_med_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036168">
        <property type="entry name" value="AP2_Mu_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022775">
        <property type="entry name" value="AP_mu_sigma_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001392">
        <property type="entry name" value="Clathrin_mu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018240">
        <property type="entry name" value="Clathrin_mu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028565">
        <property type="entry name" value="MHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10529">
        <property type="entry name" value="AP COMPLEX SUBUNIT MU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00928">
        <property type="entry name" value="Adap_comp_sub"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01217">
        <property type="entry name" value="Clat_adaptor_s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005992">
        <property type="entry name" value="Clathrin_mu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00314">
        <property type="entry name" value="CLATHRINADPT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49447">
        <property type="entry name" value="Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00990">
        <property type="entry name" value="CLAT_ADAPTOR_M_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00991">
        <property type="entry name" value="CLAT_ADAPTOR_M_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51072">
        <property type="entry name" value="MHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6 11" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0813">Transport</keyword>
    <feature type="domain" description="MHD" evidence="12">
        <location>
            <begin position="167"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00057121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR005992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAG5107611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="422" mass="48566" checksum="54B8CAA694918631" modified="2022-05-25" version="1">MSTSAIYILDVKGKVLISRNYRGDIENGIIDKFMPLVMEREEEGNLTPLLQTPECTYAYIKYNNLYIVSTTKKNANISLVFVFLHKVVQVMQEYFKELEEESIRDNFVVIYELLDELLDFGYPQTTDSKILQEYITQEGHKLEIQPRIPMAVTNAVSWRSEGIKYRKNEVFLDVIESVNLLANANGNVLSSEIVGAIKMRVYLSGMPELRLGLNDKVLFESTGRGKSKSVELEDVKFHQCVRLSRFENDRTISFIPPDGEFELMSYRLNTHVKPLIWIESVIERHVHSRVEYMIKARSQFKRRSTANNVEIVIPVPNDADSPKFKTTIGSVKYSPEQNAITWSIKSFPGGKEYLMRAHFGLPSVVGEDVEGKPPIQVKFEIPYFTTSGIQVRYLKIIEKSGYQALPWVRYITQNGDYQLRTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HSZ6</accession>
    <name>A0A8J2HSZ6_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">MULE transposase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS14037</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001438">
        <property type="protein sequence ID" value="CAG5109493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HSZ6"/>
    <dbReference type="OrthoDB" id="7699664at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5109493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="83" mass="9438" checksum="EF5DC5A4E28B638B" modified="2022-05-25" version="1" fragment="single">MADFEMAFHSAVKSVFPDVVIKGCLFHFTNAIWKNIQSNGLQAEYAADAKYALNLKKLMVLAYVPEDDVVEAYDQLIKTKFYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MGN7</accession>
    <name>A0A8J2MGN7_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HICCMSTLAB_LOCUS5228</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5089414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MGN7"/>
    <dbReference type="OrthoDB" id="19174at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="40"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG5089414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="890" mass="102798" checksum="B8AD03827E482318" modified="2022-05-25" version="1">MACNAMLLRFIEDGQVEYIKLLLENGMDVNQPIITTGEFAGFTALHVACMKNDPVLVKLLVKDYGADVNATAADGSQPLLLACLYEKCKEYPEWGGPIGTLVNAKANVDIEFGKKILFKHFKDREWYPDFGEKIPLVAYLILNNESDKTLLFKECNINMISRSNKTLLMYLIEKGNIYNTDKLISRSKVSILMENLINHRDDDDVPLSHYPLHPKKFGNFRCHTDTLFETNSVTFDYELLRHGIDKYALINNDPATFLPNLAAYRCAPSMLELFLPYYTSMPLSRILHYATLPIDENSDNLIYLGPLNRKSKQIEKKCIEIALKDLVFRRAIKSPVPKEEIELMDKLISSDKNISNIVRNYKKKITGIYSLNVEFGNKKMKMSDFLMLAYDDKKIKLLAQGESSLDDFFEDYKLNLDKNGMDVNQPIITTGEFAGFTALHVACMKNGPVLVKLLVKDYGADVNATAADGSQPLLLACLYEKCKEYPEWGGPIGTLVNAKANVDIEFGKKILFKHFKDREWYPDFGEKIPLIAYLILNNELDKTLLFKECNINMISRSNKTLLMYLMEKGDIYNTERFILRCEVSIWMEKLINHRDDDDVPLSHYTLHPKKFGNFRWNKYTVFDTIFETDIDCFDYELIKHGADKCALINNDPATFLPNLAAYRCSPKMLKLFLPYYTSMPLSRILYYATLPIDENSDNLIYLDPEINNRSHYLKNIKKIRNECIEIALKDLVFRRAIKLPVPKEEIELMDKLISSDKNISNIVSNYKKRISDIYFVNIELGDKKIKMSDFLMLAYNDKKVKLLAQEESSLDAFSDGYRRLDRDNNFDDYFQAPVFGRVIYARKRLKHLENLKKVSSLREAIPLPYEVVLEIVEYLNNLHLDMFIKAFYSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MGP2</accession>
    <name>A0A8J2MGP2_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">CDK5RAP1-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HICCMSTLAB_LOCUS2851</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Potential regulator of CDK5 activity.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the methylthiotransferase family. MiaB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001117">
        <property type="protein sequence ID" value="CAG5078826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MGP2"/>
    <dbReference type="OrthoDB" id="190098at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035597">
        <property type="term" value="F:tRNA-2-methylthio-N(6)-dimethylallyladenosine(37) synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060255">
        <property type="term" value="P:regulation of macromolecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080090">
        <property type="term" value="P:regulation of primary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12160:FF:000003">
        <property type="entry name" value="CDK5 regulatory subunit-associated protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.30.20:FF:000003">
        <property type="entry name" value="CDK5 regulatory subunit-associated protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12160">
        <property type="entry name" value="Methylthiotransferase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.30.20">
        <property type="entry name" value="tm_1862 like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaA/NifB-like_rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005839">
        <property type="entry name" value="Methylthiotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020612">
        <property type="entry name" value="Methylthiotransferase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013848">
        <property type="entry name" value="Methylthiotransferase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038135">
        <property type="entry name" value="Methylthiotransferase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006463">
        <property type="entry name" value="MiaB_methiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023404">
        <property type="entry name" value="rSAM_horseshoe"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058240">
        <property type="entry name" value="rSAM_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01574">
        <property type="entry name" value="miaB-methiolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00089">
        <property type="entry name" value="MiaB/RimO family radical SAM methylthiotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43020">
        <property type="entry name" value="CDK5 REGULATORY SUBUNIT-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43020:SF2">
        <property type="entry name" value="MITOCHONDRIAL TRNA METHYLTHIOTRANSFERASE CDK5RAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00919">
        <property type="entry name" value="UPF0004"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00273">
        <property type="entry name" value="(dimethylallyl)adenosine_tRNA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01082">
        <property type="entry name" value="B12-binding_domain_containing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00413">
        <property type="entry name" value="CDK5RAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01061">
        <property type="entry name" value="methylthiotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102114">
        <property type="entry name" value="Radical SAM enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51449">
        <property type="entry name" value="MTTASE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01278">
        <property type="entry name" value="MTTASE_RADICAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="MTTase N-terminal" evidence="11">
        <location>
            <begin position="184"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="domain" description="Radical SAM core" evidence="12">
        <location>
            <begin position="329"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="91"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00053923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00074452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAG5078826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="708" mass="80727" checksum="15D528FDFF565401" modified="2022-05-25" version="1">MIKMKVINFNTVNFVEKVKALKWNYYYYYYYRKLSTEASSVLLTEKTAENSNINLNLKSENKLKIENEDDYYFENVQKNLNLNNNPLKNFKNKARENLNLKIETRENLNNSKIEAREDLNLKIKARENLKIKTRENLNLKKQNLKSGPNLSDFITNTVLKYSNETEIAPEEAHPYLPSLNAYGKKVFFDVYGCQMNVSDTEIIYSVLKSAGYERTLTLEEADVILVVTCAIRDGAEQKVWGRLASLNNLRRRRHLMGSPPLRVGLLGCMAERLKNKILEESKYVDLVAGPDAYRDLPRLLSVTEENQAAINVALSFDETYADINPVRLNGDSKSAFVTIMRGCDNMCTYCIVPFVRGRERSRPIKSILDEVRHLADSGVKEVTLLGQNVNSYRDLSEEMFPVQEKKSTELAKGFKTVYKNKIGGRRFADLLEKVAEIDPEMRIRFTSPHPKDFPDEVLHLISTKPNICKQIHLPAQSGNSAVLERMRRGYTRESYLELVNHIRELIPDIQLSSDFIAGFCGETDAEFEDTLTLMEKVQYHVAYLFQYSMREKTTAHRRFQDDVPPEVKLERMQRMANLFRAQAEKLNSQLIGTRQLVLIEGVSFHFLSTVTPKIGGNFGKFSMEVVQNFPGYNFGPKVSRRSESTLQGRTDGNTRVLIPNVEIPDGSVNRPISAGDYVVVGISTSNSNSLTGVPVSHSSISEFDKSSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MHW3</accession>
    <name>A0A8J2MHW3_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Similar to PEX1: Peroxisome biogenesis factor 1 (Homo sapiens)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HICCMSTLAB_LOCUS4081</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5084344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MHW3"/>
    <dbReference type="OrthoDB" id="8173462at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016558">
        <property type="term" value="P:protein import into peroxisome matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000149">
        <property type="entry name" value="Nuclear valosin-containing protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050168">
        <property type="entry name" value="AAA_ATPase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077">
        <property type="entry name" value="AAA-FAMILY ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077:SF12">
        <property type="entry name" value="PEROXISOMAL ATPASE PEX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="5">
        <location>
            <begin position="180"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAG5084344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="436" mass="49094" checksum="7134337C5C0EDF21" modified="2022-05-25" version="1" fragment="single">MNIVSNYQTMNCITLMATCLSIERLGTKLKTKRGLNLFTRLFKLDCLTKNERCKIMEAEANAKELSLSSDILWDYFADKTENFVLQDFVDFIEKACYIAWKRNVNSGINNHRKIILTNDDLMSTFEGFNSIASHALSLFSGSGHGWSDIGGLKDIKDCLVELLQWPLIYTELYKNAPIRQQSGVLLYGMPGTGKTMLAGAIVKECGLNFINIKGPELLSKYIGASEEAVREIFQKAQRARPCVLFFDEFDSLAPRRGHDSTGATDRIVNQLLTQFDGVEGREGVAIVAASSRPDLLDPALLRPGRLDKALLCPLPQESHREEILKVLCKKHNLTAEDFDLKALAKMTENFTGADLNAVFVQARINATEESYAKMTKNMSQKSVIKITQDCFLKSLESTQPSLTEKEIIKFNFIYRKFFNGNNFSEEIMKNQKLTLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MID9</accession>
    <name>A0A8J2MID9_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Similar to Fbf1: Fas-binding factor 1 (Mus musculus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HICCMSTLAB_LOCUS6820</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5093430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MID9"/>
    <dbReference type="OrthoDB" id="8195456at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005814">
        <property type="term" value="C:centriole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097539">
        <property type="term" value="C:ciliary transition fiber"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090162">
        <property type="term" value="P:establishment of epithelial cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033561">
        <property type="entry name" value="FBF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049390">
        <property type="entry name" value="FBF1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33689">
        <property type="entry name" value="FAS-BINDING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33689:SF1">
        <property type="entry name" value="FAS-BINDING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21007">
        <property type="entry name" value="FBF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fas-binding factor 1 C-terminal" evidence="3">
        <location>
            <begin position="485"/>
            <end position="917"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="175"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="482"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="651"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="751"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="175"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="196"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="231"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="285"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF21007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG5093430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="1008" mass="117101" checksum="7DD9417CD06D374B" modified="2022-05-25" version="1" fragment="single">MVFFVFSQREEQRSFNLYTQINNTIYFCFVPFRLVSRIGHVNIDVNKISESIENFEDLDNILLGDSRKKQNLFGIERTKENVKGTQKKVAFQDFDDDLLGDLLSDSYELNKNKLLSNNDNKIGDLFGTKSTEKLKYDTGISKNTEVNVVLSKNEPNSLLNDSLEINKTTTIVGQSTTPNSFENSHNALGTFSNSNRPDRTKKSSIMEDLFGSKPRAIASNESNLDKPVTRNVGSEESIASSKPFVLSTAGSRESRRPRPKSININDPLGILGIQDTTQSKEENPKQQIVTNTNDDLSNDLPEWLTSGKKKTNNENNKQMNNPTLKTDKSDVQNSIDNAKPPILNQDNLLQRNTISLPDISSLTNTQFDPQISIVAMQEQEHKLRAATLLSQQTYQLNNIVENQKSKLNDQEKIFDTFIKQQIDRQSMLETQIKLQQARIDHYIQALSTQKMTLPSGVPFENKDSISMTDKQNDEKLESEYLIHTLEIKKDNLEHLADIMKDKNEREIKILEDSHETQMRLMQESIDKLEKRFRQQIEEIEHDYEKRIEKLLNEKNQQEIYFKEQIENLKTDHDKAIKDIHIRHSQQIDLLQKEHIITLENISRAKEVEQQTVDFIKSHKIDVNSMLERVQKVSDGFETLYDQVRNRDTDGIIKRENSLKKQEETLKALMEQLNTQQEVLNGERKQLVIIAQKLESDTNELTHQFVENNKSINERETRLDLQEKSLINERNLFQEQIKWEREHIQCLKEAWIAEQKQQLHLLANEREAVAAERAKLEVFNNLKFNSDDIVKTELEAAIKAAHEATHQANEERRRWQEKSELLLTEHRRNEAKERQLMQTAKDLEELTQAAVIKREEGMQALREAQRIEKQHKDRLNQLQLQLEAVAERENKIAAEKIALARERLSLRVYQAEAPEKDVMNDSYCSQIKDSIYTISPQIQTHFKDIVDPKLLLLKLNLDNKFDKSHQLLSQQKNWRRSPRTSLKFTTNVCWIVSKSKSNVLLRKDMLVEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MIJ1</accession>
    <name>A0A8J2MIJ1_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS4612</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5087806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MIJ1"/>
    <dbReference type="OrthoDB" id="2134133at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="107"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="168"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="254"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="373"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="177"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="254"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="380"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5087806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="459" mass="52413" checksum="3073D74506002794" modified="2022-05-25" version="1">MSRKKSILKDKPSKMTVSSRNEVISYLESAKSKKWPESGSPWDVNSRATSSSWPEDIEEAATKKVLKLWAAVERTMYKEDDEVKLGAVMDECVQWRSQIPHYRVVGKNIEPNDEDEEEEEEVESSEVTEKVEELSPEEERLIQIKSEQVLDRLLEYIMIELEKEMDEDNIANENNNDDSKSVDKKPLENLDQVLRITPAPTYSGRRLNVSKSSKSNSRKSSANLFESFELTERTDTALRALRNAKDADYGIVDYDYDVDDEDEEEDDDDEDPDRTDAKHGRNKLGTVFNNKIVVSPVPFAVTTRESFCTLKTTPIKYAGHLLELSTPQGFNRNMNSASRLNYSYRKSSNRLPQRHSAWQSSVSPAWPKNLRLAPIDPSRLPSSKNRSIESPTIKQRGRRSLSPILRPVKPSSCHLTGDDFLEVTGKQITQSAKLTRLNRDSSSLRSYKKSAKNICRVER</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MJ61</accession>
    <name>A0A8J2MJ61_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">guanylate cyclase</fullName>
            <ecNumber evidence="2">4.6.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">HICCMSTLAB_LOCUS5170</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.2" evidence="2"/>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5089266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MJ61"/>
    <dbReference type="OrthoDB" id="60033at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004016">
        <property type="term" value="F:adenylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004383">
        <property type="term" value="F:guanylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001653">
        <property type="term" value="F:peptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007168">
        <property type="term" value="P:receptor guanylyl cyclase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07302">
        <property type="entry name" value="CHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1230:FF:000028">
        <property type="entry name" value="Guanylate cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001054">
        <property type="entry name" value="A/G_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018297">
        <property type="entry name" value="A/G_cyclase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050401">
        <property type="entry name" value="Cyclic_nucleotide_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011645">
        <property type="entry name" value="HNOB_dom_associated"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013587">
        <property type="entry name" value="Nitrate/nitrite_sensing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11920:SF504">
        <property type="entry name" value="GUANYLATE CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11920">
        <property type="entry name" value="GUANYLYL CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00211">
        <property type="entry name" value="Guanylate_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07701">
        <property type="entry name" value="HNOBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08376">
        <property type="entry name" value="NIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00044">
        <property type="entry name" value="CYCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00452">
        <property type="entry name" value="GUANYLATE_CYCLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50125">
        <property type="entry name" value="GUANYLATE_CYCLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0141">cGMP biosynthesis</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 11" id="KW-0456">Lyase</keyword>
    <keyword evidence="7 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-0675">Receptor</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="51"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="291"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="domain" description="Guanylate cyclase" evidence="14">
        <location>
            <begin position="370"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="564"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="12"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="592"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="603"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="15">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CAG5089266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="1196" mass="134204" checksum="AE14E117C03D47DD" modified="2022-05-25" version="1" fragment="single">MSPRNGSCMAESSSVRSLSSDDVSTSKSSKKKSCWKRATDPAHRRGRRIQLLQMLVLPFIPILALIVQTANTLHDILIYRQEVSDIEAQVTIATDLGKVVTGMQLERSEVAFFIYTNGSRLRFNLTQREKISPEESTMAEVMAWYTSVNAAMLDILTNQIKETDNSGVWRYLIAFKNLLRSIESIGIASVYGINYFGRGILMGDNYVSYVRHEALGRDLLNGSLTYVPSLKSLRDEILRNFRREPNFDDAIAYFDSMAMYVDELRKLQSALRDMIRDYVNSTLKDASNKQAAGIAIVVLVLVISPIIIILVRNAVATIQMYAANLAQKARELKREKRKSDTLLFQMLPPSVAQQLKQTQQVPAEYYEAVTVYFSDIVGFTEIAAENTPLEVVTFLNSVYKLFDARIECYDVYKVETIGDSYMVASGLPVRNGDKHVSEIATMALDLLAASSVFQVPKRPGERLQIRSGAHTGPVVAGIVGTKMPRYCLFGDTVNTASRMESTGEALRIHISLEMKKALDAVGGFKIEHRGLVDVKGKGLMDTYWLECKDGGIARAAELDLPTFFEDKPGAPGKKTRLSQPNLHIAPVKEPPQSQSSIESQDSNLTYECTRSTNPPSYSPASQRSRYSQPNLPTLMIPYSDIHRHSVSPDRRIRMSQPTLYSSFSGMSFTSMKGHKLSYSSLRTSGDTSINIPHQEERLSIPNVHSMQLGENAKYYGAHRGSRLSQPDIRRMLRAPDPNKRERLSQPTLVTGDYYPPRMQHQRLSQPCLLSTWNEKPIGLLSPIKQKRFGPAVKVSQRERLASLDFGTRFRYKEPKGNRDRFSIPELETQNDLKLMAGSPKQRFSLDSQLNPDNRVRRLLPIVSSPIFEHGLGKNGHLPTDGLESVIVATATPLMPPSDRQFLAPILKTPIAPLPSLPVPATSPRERMSVPEIRSASLRRLLDPPSKQRHSIAGLRQTIVHQETSQENDDKEPTDGKTVTEVEKVEVNPGTEDVKPKHIQRHYSYTYDTKDEPMEVIGKLSVKLPKKKYLESNFDENEQVITTVIETEIPMILSSPKYMKKTHVYGSEAPKWMKKCLETPGKKFDSDKNHVLKLNNQRNIIKTNKSPEKNKKRITSPSKGATRKYPEIKENIGEVTSPGLGVQQCKTSPKDTCVRIKPSGNGETKYQVAINSEFSETDICRLYGIDCDTDSEDSTSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MJ79</accession>
    <name>A0A8J2MJ79_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Small ribosomal subunit protein uS5</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">40S ribosomal protein S2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HICCMSTLAB_LOCUS2548</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the universal ribosomal protein uS5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001117">
        <property type="protein sequence ID" value="CAG5077751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MJ79"/>
    <dbReference type="OrthoDB" id="10253125at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.20:FF:000133">
        <property type="entry name" value="40S ribosomal protein S2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000004">
        <property type="entry name" value="40S ribosomal protein S2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000851">
        <property type="entry name" value="Ribosomal_uS5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005324">
        <property type="entry name" value="Ribosomal_uS5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005711">
        <property type="entry name" value="Ribosomal_uS5_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013810">
        <property type="entry name" value="Ribosomal_uS5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01020">
        <property type="entry name" value="uS5_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13718:SF4">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13718">
        <property type="entry name" value="RIBOSOMAL S SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00333">
        <property type="entry name" value="Ribosomal_S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03719">
        <property type="entry name" value="Ribosomal_S5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54768">
        <property type="entry name" value="dsRNA-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50881">
        <property type="entry name" value="S5_DSRBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="S5 DRBM" evidence="9">
        <location>
            <begin position="104"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="11"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="28"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAG5077751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="267" mass="28571" checksum="573DBB5B9D1404F5" modified="2022-05-25" version="1">MADTAPAARGGFRGGFGSRGGTGDRGGRGGRGRGGRGRGRGRGRGKEDQKEWIPVTKLGRLVRDGKIRSLEDIYLFSLPIKEFEIIDQFIGPSLKDEVLKIMPAFVAIGDSNGHIGLGVKCSKEVATAIRGAIILAKLSVVPVRRGYWGNKIGKPHTVPCKVTGKCGSVQVRLIPAPRGTGIVSAPVPKKLLQMAGIEDCYTSARGSTCTLGNFAKATYAAIAKTYAYLTPDLWKDMPLLEAPYQEHADWLSKNHRAVTGQRSADAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MJE7</accession>
    <name>A0A8J2MJE7_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to SNX4: Sorting nexin-4 (Homo sapiens)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS2623</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sorting nexin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001117">
        <property type="protein sequence ID" value="CAG5078024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MJE7"/>
    <dbReference type="OrthoDB" id="289314at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031901">
        <property type="term" value="C:early endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032266">
        <property type="term" value="F:phosphatidylinositol-3-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000786">
        <property type="term" value="P:positive regulation of autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034783">
        <property type="entry name" value="SNX4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46596">
        <property type="entry name" value="SORTING NEXIN-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46596:SF1">
        <property type="entry name" value="SORTING NEXIN-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PX" evidence="2">
        <location>
            <begin position="1"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5078024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="402" mass="46694" checksum="0ABBB7A3166C9011" modified="2022-05-25" version="1">MSGMFENGNYQMSDESDMATIDINKEFSLLDHMEISIVESEKRANDPDFEEAIRTIGSLWRRYTEFEMLRAYLEMTYPYIVVPSLPEKRVLYAWQKVTTDTFDPDFVDRRRAGLETFLLRVASHPTLSKDKQFMGFLQQTNGWRESLKAISSSQNHDVKSNPLSIPEKLEDPDKQFESYKTYATELHNNLNNFLRLRARLAEKQYHLFKLHANYGRVFSEWSAIEKELGDGLQKTGHHLDSLAAVIDSHLEEEELIADQLKEWLFGASALQAVIRRREVLQLSKEEATDSLNNAYEQRQKIVQGKLGLMSRLFGAVDSEEMRGQKCNQLEQKIVVMENTVKEVDENLTSFSIKALSDIERFQRQKDTDIKEALANYCLLQFKLAKKGLQTWQHIKQCLENMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MJR6</accession>
    <name>A0A8J2MJR6_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to Venom metalloproteinase 3 (Eulophus pennicornis)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS2912</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001117">
        <property type="protein sequence ID" value="CAG5079064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MJR6"/>
    <dbReference type="OrthoDB" id="7699651at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006509">
        <property type="term" value="P:membrane protein ectodomain proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001590">
        <property type="entry name" value="Peptidase_M12B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11905">
        <property type="entry name" value="ADAM A DISINTEGRIN AND METALLOPROTEASE DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11905:SF249">
        <property type="entry name" value="SOL NARAE, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01421">
        <property type="entry name" value="Reprolysin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50215">
        <property type="entry name" value="ADAM_MEPRO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M12B" evidence="2">
        <location>
            <begin position="259"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="425"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="424"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="428"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="434"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="439"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5079064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="485" mass="55725" checksum="86BE1A2A316C216C" modified="2022-05-25" version="1">MSPMIAIYKVRDNNDLQLAVKSTCESAKRATKHSVSLWSVIVTDWCKMFALKFIFIWLLVNKLSLVYSAELKFESSECDGPKIKGADCERGEIRFSSRHKRSTTNEIPAFVKAFGKEIYLSLTERESAFFSPATPVYRIFRAAGGTYRVDGNNDMSLYAKAKIFEDINHSASVTVDVHPDGNEYVKEGYIGSANLYFMWDPQNQKYNFHQFSDKVNDQYYEVNHKSPEARAYNSPTYLYYPYSNYYQLVPQESTIPEIIYPEILVVVDYEMLNEIHEDHILMYVIHRWNLVDMVYRGLRSPAIKFSIAGIILPMSPDSLQYFSDGSYYTNNRKNIDMNTSLNSFKRWLFLHNHIIPINSYDLAVTMLSKRPEPNSNQGWSIFNPQRGAAYPGSACEIDYYRQEVVKAAIVMDAGVYVDIIAAAHEVAHSLGADHTDGICNGPPNYIMEKVIKHSSRVVEWSQCTVEAFQNFLRKNPTCLYNKPKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MMA0</accession>
    <name>A0A8J2MMA0_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Similar to sgg: Protein kinase shaggy (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HICCMSTLAB_LOCUS7849</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. GSK-3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5095720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MMA0"/>
    <dbReference type="OrthoDB" id="272141at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007276">
        <property type="term" value="P:gamete generation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090090">
        <property type="term" value="P:negative regulation of canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032436">
        <property type="term" value="P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070507">
        <property type="term" value="P:regulation of microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14137">
        <property type="entry name" value="STKc_GSK3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000055">
        <property type="entry name" value="Glycogen synthase kinase-3 beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000009">
        <property type="entry name" value="Glycogen synthase kinase-3 beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050591">
        <property type="entry name" value="GSK-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039192">
        <property type="entry name" value="STKc_GSK3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24057">
        <property type="entry name" value="GLYCOGEN SYNTHASE KINASE-3 ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24057:SF0">
        <property type="entry name" value="PROTEIN KINASE SHAGGY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="54"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="382"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="385"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="408"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="84"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAG5095720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="430" mass="48072" checksum="40BD1F6B13EA2DE8" modified="2022-05-25" version="1">MSGRPRTTSFAEGTKPPANPPLGGMKISSKDGSKVTTVVATPGAGPDHPQEVAYTDTKVIGNGSFGVVYQAKLCDNGEMVAIKKVLQDKRFKNRELQIMRRLEHCNIVKLKYFFYSSGDKKDEVYLNLVLEYIPETVYKVARHYSKSKQTIPMSYIKLYMYQLFRSLAYIHSLGICHRDIKPQNLLLDPESGVLKLCDFGSAKHLIRGEPNVSYICSRYYRAPELIFGAIDYTTKIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTRDQIREMNPNYTEFKFPQIKSHPWQKVFRARTPPEAMDLVSRLLEYTPPLRITPLAACAHQFFNELRDQGTLLPNGRELPPLFNFTEQELRIQPNLNSQLLPKYMRSSETTTDGGQPTETTTATASASGNSTDSNVNTTTPSVTQNADANQSTMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MMK6</accession>
    <name>A0A8J2MMK6_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Similar to DAAM2: Disheveled-associated activator of morphogenesis 2 (Homo sapiens)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HICCMSTLAB_LOCUS8997</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5098027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MMK6"/>
    <dbReference type="OrthoDB" id="1104827at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030838">
        <property type="term" value="P:positive regulation of actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.2220:FF:000009">
        <property type="entry name" value="Disheveled-associated activator of morphogenesis"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000800">
        <property type="entry name" value="Disheveled-associated activator of morphogenesis"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.2220">
        <property type="entry name" value="Formin, FH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.150">
        <property type="entry name" value="Formin, FH3 diaphanous domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014767">
        <property type="entry name" value="DAD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015425">
        <property type="entry name" value="FH2_Formin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042201">
        <property type="entry name" value="FH2_Formin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010472">
        <property type="entry name" value="FH3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051425">
        <property type="entry name" value="Formin_Homology"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014768">
        <property type="entry name" value="GBD/FH3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010473">
        <property type="entry name" value="GTPase-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45725:SF1">
        <property type="entry name" value="DISHEVELLED ASSOCIATED ACTIVATOR OF MORPHOGENESIS, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45725">
        <property type="entry name" value="FORMIN HOMOLOGY 2 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06367">
        <property type="entry name" value="Drf_FH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06371">
        <property type="entry name" value="Drf_GBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02181">
        <property type="entry name" value="FH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01139">
        <property type="entry name" value="Drf_FH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01140">
        <property type="entry name" value="Drf_GBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00498">
        <property type="entry name" value="FH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101447">
        <property type="entry name" value="Formin homology 2 domain (FH2 domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51231">
        <property type="entry name" value="DAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51444">
        <property type="entry name" value="FH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51232">
        <property type="entry name" value="GBD_FH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GBD/FH3" evidence="4">
        <location>
            <begin position="76"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="domain" description="FH2" evidence="5">
        <location>
            <begin position="633"/>
            <end position="1033"/>
        </location>
    </feature>
    <feature type="domain" description="DAD" evidence="3">
        <location>
            <begin position="1064"/>
            <end position="1095"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="594"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1021"/>
            <end position="1070"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1086"/>
            <end position="1119"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="476"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="912"/>
            <end position="946"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="602"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1021"/>
            <end position="1045"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1104"/>
            <end position="1119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAG5098027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="1119" mass="127501" checksum="7A31555F6A8747B2" modified="2022-05-25" version="1">MDTVLEKIGKFNLRIPSCSLKSPQPLKEFVVHCQTMPSRVKKSFCGCLQDDEPPEITYCVVEQTGTLTLQAMTPTLPMPAEEELNKMFLELVDELDLTQANRQAVLALPANKKWQIYCSRKGNDTLDNGGLRTTDLSGDPEDYINRIRVIASTTFSEDAEELSNQMRQAEALKTALRTQPHSFVLRFIELDGLNALLQVLGTIDVEAANSNLHTSVIGCLKALMNNSNGRAHVLAHPTAINTISQSLATENIKAKISVLEILGAVCLVPGGHRKVLEAMLHFQQFHSERTRFQSIINDLDRNFGVYKDNLSLKTAIMSFINAVLNYGPGQVTMEFRLHLRYELLMLGIQPIIEKLRKYENETLDRHLDFFEMVRNEDEKELARKFEKEHVDTKSATAMFDLLRRKLSHTAAYTHLLSLLEHCLLLPLDYGSYPQHWLLFDRIVQQIVLQSEGSEAGKARNPDVAPIDINVKEIVHLLAKEEELVAARKRAEELERDNCEMSSRLAKKEQELDLRTQEKEDMEASLARIKERLEKETSMHIETKQKISELQDNVETLSRQVNNEKSERKRLEQLVASGSLPDDAKATIKIVDDDVEEKVESKPTPPPPPPPPLAPPPPPCLMPIAPPPMKMEIIKNVPQPSNPLKSFNWSKIPEQKLQGTIWSELDDSKLYNVMDLESIDKIFCAYQKNGIPAEGSIEDLRNLGKNKKTMSVIDSRRAQNCTILLSKLKMSDNEITRTILSMDQQNILHIDMVEQLLKYIPSSEEAALLDMNQKDLQSRADCFLYQISKVPHYEQRLRSLHYKKKFSASIAELTPRMRAVLEASRQVARSRRLRKLLELVLALGNYVNRGNARGNACGFRLASLNRLVDTKSSCSKGTTLLHYLVQILESRFREVLDIEEDMPHVKTAARVSMADLQKEVANLKNGLQDVQREIEFHRAQAQVLQGDMFLPAMRDFQAQATCRLAEAEDLFQDMKTRFDRAVRLFGEDSAGVQPDEFFGIFENFLQALTEARADVENMRRKVEEEERRAKQEQELKKRTMERKNSREGILNSIALNKKNESNGQGDNKGEFDDLISALRTGDVFGEDIAKFKRSKRRPVTPSSQDSRRHSIHREDSRERH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MMS7</accession>
    <name>A0A8J2MMS7_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Similar to Fcp3C: Follicle cell protein 3C-1 (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS7730</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5095481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MMS7"/>
    <dbReference type="OrthoDB" id="7412264at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019171">
        <property type="term" value="F:(3R)-hydroxyacyl-[acyl-carrier-protein] dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050965">
        <property type="entry name" value="UPF0336/Enoyl-CoA_hydratase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43437:SF3">
        <property type="entry name" value="HYDROXYACYL-THIOESTER DEHYDRATASE TYPE 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43437">
        <property type="entry name" value="HYDROXYACYL-THIOESTER DEHYDRATASE TYPE 2, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5095481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="222" mass="24911" checksum="B28B16985607C3E6" modified="2022-05-25" version="1">MYLLKLTRRLSISSRKFTSEFNFERKFKVGDKVSVVRKITDDDVLNFAKLTNDYNPIHVSAEKKLVHGALLNGFLSGVLGTKLPGPGTIVMTLRLVLLLFCVSAVRGREHENSASVVNNITPDYTDDNSTITTEAPLGCVCGIYLFEAKKLTKELPEGDPVISHNISEKFPNNPDGHKSALNRDCYKERAHLFIRNGSDKWIRTNLSAGREYCCKNNLPYKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MN68</accession>
    <name>A0A8J2MN68_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS8196</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5096411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MN68"/>
    <dbReference type="OrthoDB" id="7617281at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="12"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5096411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="80" mass="8417" checksum="5D5DEA555978824A" modified="2022-05-25" version="1">MAESAGSPAAVTTANSPQQQQPQQQQQQSQTQTQTQTNASTQPPDISSSQLASPPITGTDIILMEIILADILLPTCSKKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MN87</accession>
    <name>A0A8J2MN87_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Olfactory receptor 21</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HICCMSTLAB_LOCUS8726</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5097475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MN87"/>
    <dbReference type="OrthoDB" id="6617147at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005549">
        <property type="term" value="F:odorant binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004984">
        <property type="term" value="F:olfactory receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004117">
        <property type="entry name" value="7tm6_olfct_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21137">
        <property type="entry name" value="ODORANT RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21137:SF35">
        <property type="entry name" value="ODORANT RECEPTOR 19A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02949">
        <property type="entry name" value="7tm_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0552">Olfaction</keyword>
    <keyword evidence="8 11" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="9" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="39"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="73"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="126"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="180"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="267"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="303"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="379"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAG5097475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="403" mass="45959" checksum="AD4776A786894F02" modified="2022-05-25" version="1" fragment="single">ITLNKKGFKYAIAWNRTSMKIVGLWPEPDDGVVTKLRGWFSACLIILIIYLPQSASVYCYWGNMDAVIECLSINGPVLITIVKIIIFRYSRKVLQRVINAMEEDWSVSRSDEEFAVMLKTAKISRAISVISTAVTNSLFVAYIFFKESYEMSKRTDLDPRLSVGLLHPAYFPYDTKKIRLFVPTWIAQLIATFFSMTAYAAFDTFMSCMVLHICGQLAVVGITLRKLINESTKNNPRKFWSEFSIIVERHEKLNELAKVIEDSFSSILLPQMIICTTTFCFQGFAMISSFINPLAGKVSVLEMLFSIVYVIYTVLHLFVYCYVGDYLSFESSRIGEAYYKGNWYNLSVDKSRSLMFVGHRARRPLKITAGKFCAFSRNLFLVVLKTSFGYLSMLLAVKKGNPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MPA4</accession>
    <name>A0A8J2MPA4_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Similar to Transmembrane protein 256 homolog (Bufo gargarizans)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HICCMSTLAB_LOCUS7727</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM256 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5095475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MPA4"/>
    <dbReference type="OrthoDB" id="269173at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006696">
        <property type="entry name" value="DUF423"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43461">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 256"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43461:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 256"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04241">
        <property type="entry name" value="DUF423"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="61"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAG5095475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="165" mass="18025" checksum="9C5068705D37F7ED" modified="2022-05-25" version="1">MSFYDAINYVVFTNPLSATAGQLAKSTADAIVSYSGLTPKVEYKMIPPEPLWKLAASSGPFIRLAGINGAAAVILGAYGAHRKFPDDNLKQVFETANRYHFYHALAMLGLSLCRAPMITAAFWLSGTMMFSGSCYYYAFTGDKRLSKITPFGGTCFILGWLTMCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MQF3</accession>
    <name>A0A8J2MQF3_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Similar to map3k10: Mitogen-activated protein kinase kinase kinase 10 (Xenopus laevis)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HICCMSTLAB_LOCUS8133</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5096285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="339325at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903078">
        <property type="term" value="P:positive regulation of protein localization to plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003009">
        <property type="term" value="P:skeletal muscle contraction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12059">
        <property type="entry name" value="SH3_MLK1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22249">
        <property type="entry name" value="UDM1_RNF168_RNF169-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035779">
        <property type="entry name" value="MLK1-3_SH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039688">
        <property type="entry name" value="STAC1/2/3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15135">
        <property type="entry name" value="STAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15135:SF7">
        <property type="entry name" value="STAC-LIKE, ISOFORM J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14604">
        <property type="entry name" value="SH3_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 9" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="13" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SH3" evidence="12">
        <location>
            <begin position="114"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="33"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="73"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="331"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="645"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="994"/>
            <end position="1029"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1110"/>
            <end position="1135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1180"/>
            <end position="1199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1207"/>
            <end position="1256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1290"/>
            <end position="1328"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="271"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="34"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="73"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="85"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="98"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="334"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="645"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="656"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="679"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="695"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="751"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="802"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="994"/>
            <end position="1007"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1117"/>
            <end position="1134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1186"/>
            <end position="1198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1210"/>
            <end position="1224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1239"/>
            <end position="1256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="1307"/>
            <end position="1316"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAG5096285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="1328" mass="146443" checksum="C4E59C3BB305B1C0" modified="2022-05-25" version="1" fragment="single">MPPAGLSAKGLCTLMDNGQPDARHRSERYLLYTENGSSQPNTPSTATSSPRYHNATRDNNYSVSYGYSYGRTSSNNMSDSSVSDTHSGGTARTVSQQTSPSHATLSSSHSRQDNSATLFTALFDYNATCEDELSLQRGETVEVLSKDSKISGDEGWWTGKIRGQVGIFPANFVAEAECIDRVSSVIDKVQPVEIDFNELQLEEVIGVGGFGKVYSYGLGCWASDSHGRPGFIEILDLLDEVRSSFAATPHESFHTMQEDWRLEIEEVLHGLRMKEKELRCREEELSKAQVQQKQQEENLRQREQELAAREIDLLERELTVMIIQQQTVPTPNMRKGKFKKSRLKLNKKEPGSNISAPSDFRHTITVQHTALDRGKNRNPSRPNSPPGSPIPADGVKGKTWGPSTLHQRERGAIITQPPNPSSPGGKRWSRSAPDLEKTPLRTALLASAQRSPLLQEIGNPTTRKLYSSANNLIDDQERSGAASDYELMRIITNDDDLTMTSSSSCALGGGQSSCVTMSGLRGSNIIKNNNSNNINTATQMDTYETAYDDLRDTLTQQINRTPLVGVGIGALAYNYYDISSPTSSVSSTSTLVPSDSASAFLSSSSSCAVKSSAGKQLESPSSAEQSVNSTNFVHNVASTLVGTAKRVRNKKRDRSKSKEFKRRDSSESRLNSLAEFFRSPTSSRKSSLASEKKNSQALASSSTRKSSSADCSGAGGIESSPENSITKSVRHKSRSSKSPLRVLHKMRAWDSTPTTSTANQSFGNSETALSVSTNKQNSQLHNDDGKSRSIEYLFDSSHQPTSSSSSNSISNLNSNSNNIPSEEIRKFSRSHYPTLPADMSSEWMTMEYPPKPGLTGPYVMPMPVPMPTLYNGEAKKPKPGIIELVLYNIAAMLAGVATGYDVKMSNVSPIHPRLYPRVTDGEEEPGRYWFQADTGSNRNSGYLGADYEFSSPSGYPHNTYHGPARHYRPFLSNMGGIAPGLPLNIIDKPLRFTDSPQHYAGNTGSNVPTPSPRRKSSSTSNEEAYSADNARMDRIERVPTIYMGNVPPYPDYGPPMYTMMPPEYYRPPESSYFNPTDYHDRMLECPEFPHAYDNPSTINSLVRTSSRLPNYTHHRTSSNVSTTSTSSQSNINPSFRLDDESDYALYSPTHYYQRSQNVLSNIGLSYTGVNHDYTASPQYLTRQNSHDSNPNSSDRPSNLEVVTRLRSSLKRSNYSYNSPKSTSKNNSGSGTPTNPTPPDSLTSEDSSYVSAKDSQISMSRVRFSPVTFDRDRDRDSLSSSRDHRDALLDIPIHAQGSEAVTSPLQSSRRHNSRNRKSSISELEREFLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MQI1</accession>
    <name>A0A8J2MQI1_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Odorant receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HICCMSTLAB_LOCUS10617</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Cell membrane</location>
            <topology evidence="1 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the insect chemoreceptor superfamily. Heteromeric odorant receptor channel (TC 1.A.69) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5101715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MQI1"/>
    <dbReference type="OrthoDB" id="6604226at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005549">
        <property type="term" value="F:odorant binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004984">
        <property type="term" value="F:olfactory receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004117">
        <property type="entry name" value="7tm6_olfct_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21137">
        <property type="entry name" value="ODORANT RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21137:SF35">
        <property type="entry name" value="ODORANT RECEPTOR 19A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02949">
        <property type="entry name" value="7tm_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 10" id="KW-0552">Olfaction</keyword>
    <keyword evidence="8 10 11" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="9 10" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="48"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="113"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="158"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="270"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="300"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU351113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAG5101715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="394" mass="44666" checksum="82991FAB6AB30CC7" modified="2022-05-25" version="1">MCGIWSLDSSTPVSLKLLHNISNILGIIALAIFVGTLTADLMGNLNDLLIATDDGCYLAGISVIIFKVYKFHRQHKRIKNLTDATYRPINEFKKSKDSGVKEILETNKFYEDLGFTFFVTLGGFLVIALIFFVPTEDGALPIRALYPFNTTVSPMHELAFTLQIYAVSYGLMAILMMDTVGLGIMRWLHVQCIILAANYKNCRLDNQSTYLKCQENSDVIRTFSTFDEQDKEITGSTDCFVARFRRCIKNHQRLLYTIDELNACFSSSMLMQLFASFSMICLTGFQAVLGATTKTSLMKFVLYLGAAFSQLLYWCWFGNELLYERMTLLSSQWMSGWENELGSNIQPLLIVSMIQTMRPLELHAGPFFTMSMETFISIIKSSYSFFALLTTMTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MS35</accession>
    <name>A0A8J2MS35_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">rRNA biogenesis protein RRP5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HICCMSTLAB_LOCUS11437</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5103293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="412781at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05693">
        <property type="entry name" value="S1_Rrp5_repeat_hs1_sc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000196">
        <property type="entry name" value="rRNA biogenesis protein RRP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003107">
        <property type="entry name" value="HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059164">
        <property type="entry name" value="HAT_PRP39_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045209">
        <property type="entry name" value="Rrp5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048059">
        <property type="entry name" value="Rrp5_S1_rpt_hs1_sc1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23270">
        <property type="entry name" value="PROGRAMMED CELL DEATH PROTEIN 11 PRE-RRNA PROCESSING PROTEIN RRP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23270:SF10">
        <property type="entry name" value="PROTEIN RRP5 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23241">
        <property type="entry name" value="HAT_PRP39_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00575">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00386">
        <property type="entry name" value="HAT"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="S1 motif" evidence="10">
        <location>
            <begin position="84"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="10">
        <location>
            <begin position="187"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="10">
        <location>
            <begin position="436"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="10">
        <location>
            <begin position="527"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="10">
        <location>
            <begin position="608"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="10">
        <location>
            <begin position="812"/>
            <end position="873"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1036"/>
            <end position="1080"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1105"/>
            <end position="1142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1036"/>
            <end position="1045"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1128"/>
            <end position="1142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00073619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAG5103293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="1422" mass="160183" checksum="56B4F8B055C777FB" modified="2022-05-25" version="1">MLVSRFCYNNNNNDLAMKFKSKAARWQHKYLFALYFFSKKFLGNKRKRSAKFNQSKTIKDAQKGEQDFGPSSAECLTYPTIVEGMVILGRVYTATEYDITVSLPGRLSGQVLATDVSEAYTSLLEKVIEITDNQLTEYKPLNEVYKNGDYVVCVVKSINPDEKNAVKLSLEPGLINQSLHPESLKSGCKIACSISSVEDHGYVIDTGIKTLRGFLANKDVAENAKYHHGQQIFCSIKKVKTDENIVTLNLTTKSKRITSSVSVDSLQLDSLVPGSRIDLTVKKILRNGLRVSFNENNTGYINQLYLNEPLSSYEPDTEITATLLYVIPTVKFAYFTEFSFEKEKQPIQVGEIINKASVLYRDAKGIIFKLKEGVKGFVSFKRTEVNFENINAKFPPESIHKCRVLSYDLSDRLYICTMQKNLLKANSCIADTVEPGEILTVEIVRFNKNGFIFVKSGNTFGDVAPMHIADPGIDLKKKQQLLKVGARVSARVLGRNKQGNGWMLTLKKSLVESKRPILSNVEDASVGSIYQGTIFSVKKEGLLISFFGEVKGFLPSKFLNKTTGGTLNYSVGQVILVKIEKVNEGGKLILNLAHNKSNLKEEIKLNIGEEVTGVIVESSSEGIYLKISKGNKGDSVTGFLPAGHIAPCKELGAHLAAKYVPGDLLTALVFSTSPKFLLSRTYVPQKELTKMENLKKDDYIPCSITDISSKGVKVVLPIEGFDEYGFIPYNKISDIESLSVHQLLFGKVTFINKKEKKIHLTAALHEVWTDAVKQDTDMVGAVDVLTLYLSKLKEMATHENFTNKSISAMNLGQHVKGVVEKVTEHGLVLKLENDVAATVRSCHIEKPHKEGDQVEATVLWINYIHELVEVTLLPKLNNSIRNQVNKLPDDSINVQLKGEIVLVTNWFALVLLKGQGKGTLVSLPTRRHANDMKPDLSSYSVGKKIRCYVILNRGEAELTPVAVVKSSFESRKHMIELQNSKDLKRKNPSYIHSEHLLSKRPKLLTKIINCDEVKDEVEVKNEEESDDEVNEVQVVKEKKNNDQAKKNKKEKVKQLEVKNKKISPQVEAKNKKISPQVEGENKIADSLSIPECGFNWDGTLNQVKIEESSSSSEEEEDNEPKKKKKKLTAAERHELERQKEREIRQREEALASNQMPNSPDQFDRLVLASPDSSVIWLQYMAYHLQATEIDKARAIAKRALKTINLREEHEKLNVWQGWLNLESRFGTPDTLDSVFHEALKLNDAKKIYLHMITAHTDAGRHLKLEEFVKVVTGKFKQDPEVWTECGGAYLKAGLKEKSRFLMQRALQSLQPKEHVNLIMKFAQMENRFGDAERAETLFEKLLTSYANKVIVWTCYVDMLVKSEKFDTARKVLEKAVLQSLPPKKMKTLFEKYVSFEEKYGTPAGVEHATKLAKEYLDKIIKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MSB4</accession>
    <name>A0A8J2MSB4_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase</fullName>
            <ecNumber evidence="6">3.1.4.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">HICCMSTLAB_LOCUS9027</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="6">The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6 9">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+)</text>
            <dbReference type="Rhea" id="RHEA:33179"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:58456"/>
            <dbReference type="ChEBI" id="CHEBI:203600"/>
            <dbReference type="EC" id="3.1.4.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <text evidence="8">Binds 1 Ca(2+) ion per subunit.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.11" evidence="6"/>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5098087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MSB4"/>
    <dbReference type="OrthoDB" id="269822at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004435">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate phospholipase C activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008344">
        <property type="term" value="P:adult locomotory behavior"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043153">
        <property type="term" value="P:entrainment of circadian clock by photoperiod"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042592">
        <property type="term" value="P:homeostatic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046488">
        <property type="term" value="P:phosphatidylinositol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048015">
        <property type="term" value="P:phosphatidylinositol-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051209">
        <property type="term" value="P:release of sequestered calcium ion into cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00275">
        <property type="entry name" value="C2_PLC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13361">
        <property type="entry name" value="PH_PLC_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08591">
        <property type="entry name" value="PI-PLCc_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000024">
        <property type="entry name" value="1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.240:FF:000001">
        <property type="entry name" value="1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000008">
        <property type="entry name" value="1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1230.10">
        <property type="entry name" value="Phospholipase C beta, distal C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001192">
        <property type="entry name" value="PI-PLC_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016280">
        <property type="entry name" value="PLC-beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042531">
        <property type="entry name" value="PLC-beta_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037862">
        <property type="entry name" value="PLC-beta_PH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053945">
        <property type="entry name" value="PLCB1-4-like_EFh"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000909">
        <property type="entry name" value="PLipase_C_PInositol-sp_X_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001711">
        <property type="entry name" value="PLipase_C_Pinositol-sp_Y"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10336:SF36">
        <property type="entry name" value="1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10336">
        <property type="entry name" value="PHOSPHOINOSITIDE-SPECIFIC PHOSPHOLIPASE C FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17787">
        <property type="entry name" value="PH_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00388">
        <property type="entry name" value="PI-PLC-X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00387">
        <property type="entry name" value="PI-PLC-Y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22631">
        <property type="entry name" value="PLCB1-4-like_EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000956">
        <property type="entry name" value="PLC-beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00390">
        <property type="entry name" value="PHPHLIPASEC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00148">
        <property type="entry name" value="PLCXc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00149">
        <property type="entry name" value="PLCYc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69989">
        <property type="entry name" value="C-terminal domain of PLC-beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50007">
        <property type="entry name" value="PIPLC_X_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50008">
        <property type="entry name" value="PIPLC_Y_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0106">Calcium</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 6 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 6 9" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="4 6 9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0807">Transducer</keyword>
    <feature type="domain" description="PI-PLC Y-box" evidence="13">
        <location>
            <begin position="654"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="12">
        <location>
            <begin position="773"/>
            <end position="899"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="929"/>
            <end position="965"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="1154"/>
            <end position="1188"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="428"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="475"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="429"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="458"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="460"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="509"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR000956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000956-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000956-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CAG5098087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="1199" mass="138182" checksum="68BDEC26A48DBF71" modified="2022-05-25" version="1">MRFIVWGYPDLQTKQTNHKISQVVCSGYKSFVKRVHRPSDTTRLSNRLWRPKYYNFVSLNLYPERGSRAQVYYTIGFLIAEQLSESYKNKKINRDKNINNMTKRFEFNWQIEVPEALREGCVFDRWTEEKDNTEIELNCLFKVDEYGFFIYWQSEGKDGDVIELCQVSDIRAGGVPKDPKLYDKLVAKHGEQLDDKSLAICSGVDYTNINYQHVVCPDVNTAKIWLAGMRRITHNVKANNICPLTCLKKHWMRLRMLVDPNGKVPVKVVARTFASGKTEKLVYQCLSDLGLPSGKNDVIEPDDFTFDAFYALYHKICPRNDIEELFQSITQGKADTINLEQLITFLNEKQRDPTLNEILYPLYDDKRAFEIINDYEQNETYRNQKTMTKDGFIRYLMSDENAPVFLDRLDVYMDMDQPLSHYYINSSHNTYLSGRQFGGKSSVEMYRQVLLAGCRCVELDCWDGKGEDEEPIITHGKAMCTAILFKDVIYAVRDTAFVTSEYPVILSFENHCSKTQQYKLAKYCDEILGDLLLKEPLKDYALEPGVPLPPPSLLKRKILIKNKRLKPEVEKQELELFKQGQFVIEDEIKEDASAPAVVAGVVEQQSVDSAVVDVVAVQQNSSNSGVGPAGLGDSIELAVVQPYTGSTTNVHPWLSSMVNYAQPIKFQGFDEAEQKNMHYHMSSFAENTGLNHLKTSAIEFVNYNKRQMSRIYPKGTRADSSNYMPQVFWNAGCQMVSLNFQTADLPMQLNQGKFEYNGSSGYLLKPDFMRRADRSFDPFAESPVDGVIATSCSVQVIAGQFLSDKKVGTYVEVEMYGLPTDTIRKEFRTRVVPANGLNPVYNEEPFLFRKVVLPDLAALRFAVYDESNGKLLGQRIVPLDGLQSGYRHIALRTEANFPMSLPMLFCNIEIKIYVPDGFQEFMDALTAPRAPRKTEIPSQPRTRGQDEDSKISGDSSQARSIEAAKPREIMDFEPITMEVLSQEKAYQKLVRKQQKELESFKKRQLKERNTVQKQQCAAIEKLIKGKNKAELSRDPIVRRAVSEQTSQWSNVTERQRREEREMILGHLEERRTQLRKLCLAAQANQCKLLTTRHEREIKELNAKQARLSVESTKEVMNDKSLKSRGIKEGRLREKQQNNTKRFMEERKFAQMVQNREREKLKMIHNEQLEELQKEMNGMMEMHKNQQIEYELGPKNEFYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MSH7</accession>
    <name>A0A8J2MSH7_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cyclin-dependent kinase inhibitor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HICCMSTLAB_LOCUS11798</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CDI family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5104029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MSH7"/>
    <dbReference type="OrthoDB" id="9940972at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004861">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051726">
        <property type="term" value="P:regulation of cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.365.10">
        <property type="entry name" value="p27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003175">
        <property type="entry name" value="CDI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044898">
        <property type="entry name" value="CDI_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02234">
        <property type="entry name" value="CDI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0649">Protein kinase inhibitor</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin-dependent kinase inhibitor" evidence="4">
        <location>
            <begin position="48"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="86"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="25"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="104"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAG5104029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="114" mass="13679" checksum="84CF53E031065CFF" modified="2022-05-25" version="1">MDGDKRNKNTDKTKLQNVRRRLFTDTDDNQENNEEEKTTQGNDDNLANRLIEETRFEAKERWNFDFEKDEPLNGQWEWVKIDEEFSDRNPPALGNSHNNTRDNLQQEKIDNNNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MSJ2</accession>
    <name>A0A8J2MSJ2_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Similar to CG1542: Probable rRNA-processing protein EBP2 homolog (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HICCMSTLAB_LOCUS11845</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Required for the processing of the 27S pre-rRNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the EBP2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5104124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MSJ2"/>
    <dbReference type="OrthoDB" id="443772at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034399">
        <property type="term" value="C:nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008610">
        <property type="entry name" value="Ebp2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13028">
        <property type="entry name" value="RRNA PROCESSING PROTEIN EBNA1-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13028:SF0">
        <property type="entry name" value="RRNA-PROCESSING PROTEIN EBP2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05890">
        <property type="entry name" value="Ebp2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="228"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="9"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="306"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG5104124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="320" mass="37096" checksum="47B262BCE549162E" modified="2022-05-25" version="1">MKRKSSHIEEEEESDSEIDSEEELQDAFAKGLLKPGLNKVIEKTVKKSINQPELLKEALNKLKLDLPWIEKLDVVNAPAPLAPELALQQLEQEERRAKQLKGNKKLAQLKPTEDPVINDFKRETMFHRQAQAAVMFCMPRIKKLGIPTIRPEDYYAEMAKTDEHMHKIRTTLQKKEQAVARSEKVRQLRLQRKVGKQMQVEATLKKHAEKKQMLDEVKKFRKGVRKDLNFLDDKKKPGSSNKSHAERRLSNKQKVKNSKFGFGGKKRGTKMNDRESSADMSGYQRPRKDIKGLKRRDKGGNNKSQRPGKNRRVQMKNKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MSL9</accession>
    <name>A0A8J2MSL9_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS6639</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5093168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MSL9"/>
    <dbReference type="OrthoDB" id="7698088at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5093168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="103" mass="11646" checksum="D9E426A3AF5912EB" modified="2022-05-25" version="1">MDLSKINAISVLPPFLPTTKLSDLTIGNEYQITNVKKVNTKYGARVIATVGKEFNIFLPKRTSAAIIEDPQQFEQLTNAISNNNIYFLYHGGQYHDIEIIFRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MSS6</accession>
    <name>A0A8J2MSS6_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Mediator of RNA polymerase II transcription subunit 6</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 9">Mediator complex subunit 6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HICCMSTLAB_LOCUS12071</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the Mediator complex subunit 6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5106048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MSS6"/>
    <dbReference type="OrthoDB" id="344220at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.580">
        <property type="entry name" value="Mediator complex, subunit Med6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007018">
        <property type="entry name" value="Mediator_Med6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016820">
        <property type="entry name" value="Mediator_Med6_met/pln"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038566">
        <property type="entry name" value="Mediator_Med6_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13104">
        <property type="entry name" value="MED-6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04934">
        <property type="entry name" value="Med6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF023869">
        <property type="entry name" value="Mediator_MED6_meta/pln"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0010">Activator</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 9" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="188"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="210"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR023869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAG5106048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="237" mass="27187" checksum="77CDBCA47F67939B" modified="2022-05-25" version="1">MMPGRHPVSDNPLGLSWHDSAWIPVLNPTNIMDYFSERSNPFYDSTCNNETVKMQRLSPDQLQNMTGCEYVLLHVQDPILYVIRKQHRYSPTQVTPLADYYVIAGTVYQAPDLASVVNSRLLSTIHHLQSAFEESSSYSKYHPSKGYSWDFKNGKPLSTKKEAPLREEPSSLFQRQRVDMLLAEITRKFPPPAPKPIQQPAEQPVPAAEIKQEILTLKEIKTEKRDMKPPPERKPRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MSW6</accession>
    <name>A0A8J2MSW6_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similar to Nol4: Nucleolar protein 4 (Mus musculus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS9270</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5099859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MSW6"/>
    <dbReference type="OrthoDB" id="10047222at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="122"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="157"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="132"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="159"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="205"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="217"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="234"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="245"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="274"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="288"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="335"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="349"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="359"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5099859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="557" mass="62023" checksum="590C54604127AE01" modified="2022-05-25" version="1">MGIVTRADRNPLIGLVSSPRVKLYFNRGQHFQANIFKHRLSIFLIFLQALSGAEGTVPGRVYKKVAIVENFFDIIHAVHVDLEGRPGKHAGQKRTYRTITETYAFLPREAVTRFLLGCTECQRRPRSPSPSPNNLANQSQSAAAAAAAANIVATSSEITPVSRTPRSPTPAVALSATPAQSSPRPREASNPPESKSLFNYRHPKQQQQHLTQQHVGQQHHQHVHRHTGVEKMNCGNNNTSSNIVSTPTNTSIIPNNNNNNNKDKEVDPQNQSQHQHHHHHHHHHHHHQEKDTISSKPAKKDKPQLIPKENKEKEKEKEEKYNPLSISNLIKKEPTNFTPTTTENLSPIAVTTPNTENALESRRTPESDRGSSRSSASSKRKRMLPEGRTPSPLPGPIARPWSPGIDLSKDTPVDYSLPITTTYLKHQQKMIAEKNKATMAAIALEEVQRKCREEEELLKSNAVGGVGVGESISLERDQYSPAGLIDTNLSLLATIQHLHCQVMMALTERLRPSGLPTSLMVPPPPTILPIHHHHHHHLPHGFIRDMSIPAALAYNHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MYC2</accession>
    <name>A0A8J2MYC2_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">dolichyl-phosphate-mannose--protein mannosyltransferase</fullName>
            <ecNumber evidence="6">2.4.1.109</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">HICCMSTLAB_LOCUS12733</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Transfers mannosyl residues to the hydroxyl group of serine or threonine residues.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate + L-seryl-[protein] = 3-O-(alpha-D-mannosyl)-L-seryl-[protein] + a di-trans,poly-cis-dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17377"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:13546"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19501"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
            <dbReference type="ChEBI" id="CHEBI:137321"/>
            <dbReference type="EC" id="2.4.1.109"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate + L-threonyl-[protein] = 3-O-(alpha-D-mannosyl)-L-threonyl-[protein] + a di-trans,poly-cis-dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53396"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:13547"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19501"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
            <dbReference type="ChEBI" id="CHEBI:137323"/>
            <dbReference type="EC" id="2.4.1.109"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the TMTC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.109" evidence="6"/>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5107406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MYC2"/>
    <dbReference type="OrthoDB" id="19588at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004169">
        <property type="term" value="F:dolichyl-phosphate-mannose-protein mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030968">
        <property type="term" value="P:endoplasmic reticulum unfolded protein response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052346">
        <property type="entry name" value="O-mannosyl-transferase_TMTC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013618">
        <property type="entry name" value="TMTC_DUF1736"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44227">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44227:SF3">
        <property type="entry name" value="PROTEIN O-MANNOSYL-TRANSFERASE TMTC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08409">
        <property type="entry name" value="TMTC_DUF1736"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13432">
        <property type="entry name" value="TPR_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81901">
        <property type="entry name" value="HCP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50293">
        <property type="entry name" value="TPR_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="13 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <keyword evidence="10 16" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="36"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="142"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="172"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="197"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="228"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="289"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="333"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="373"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="403"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="432"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="461"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1736" evidence="18">
        <location>
            <begin position="312"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="16">
        <location>
            <begin position="534"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="16">
        <location>
            <begin position="568"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="16">
        <location>
            <begin position="602"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="16">
        <location>
            <begin position="670"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="16">
        <location>
            <begin position="704"/>
            <end position="737"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00045085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00045102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF08409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="CAG5107406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="759" mass="87790" checksum="2A95C6BEEEAE1D23" modified="2022-05-25" version="1">MFKIYILKYVFISIIHINAALKTMKVKANCLPAVPPKLALSIIFISSLCCINSWNGSFVFDDSPAILNNPDVSPPESSSLSPQSPPPSASISLIRVLKKLIRNDFWGNKLTHKQSHRSYRPFTVLTFIIQRWLRGSLNPIDFHIFNLILHTFACLIFYYLLLRLLDKTARHLAFYVATLFAVHPIHCEAVAGIVGRADILCAIFVWLSVLFYNRCIYEKNLIILIKNLLMCVLCITYAMLCKEIGITAIGICYAYDLTIVHKKNLYDIITILKKESIKDIIEKNKYKCLVRIVLLLTCGLLLAIRFNLMGYSAPSFQPVDNPSSFINNLFMRYLNYQYIWSLNLWLLICPLWLSFDWSMGCVPLIKTFELRLLPVILLWLIFGVFFVKYFLNQKTYRDHRYVSMGLCMMIIPFLPASNLFFTVGFVLAERTLYLPSAGYCFVVVIGFQKLSRRFYKSRMPLIMYTVLVITWFTRSWMRSDQWRSEHTLYRSGLSVCPLNAKVHYNVAKNAADSGNITLAEAEYLEALRLNPQYAQAMNNLGNLLNNQKRYQQAKDLLTRAVGLQPDFAAAWMNLGIVLAALKQFNESKSCYEKSLSYRRNCPDCFYNLGLLYLEQKMYPRAMEAWTETLRLDKKHRRAWINTIRILDDMGKQEKALREGEKAKKVLPDDATIRLNIANILGKLERFEKAEAEFKRAAELDPTNPTIFTNLGVLYHRWHKLDKAKEMYAKALEINPNAQSAKNNMKKLENLIRKQKFKGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-10-16" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>S6CVK5</accession>
    <name>S6CVK5_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cc_cyst.2</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="6">Cystatin.2_bracovirus</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="8">Hypothetical cystatin CYST2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">cyst2</name>
        <name evidence="6" type="ORF">HICCMSTLAB_LOCUS6058</name>
        <name evidence="7" type="ORF">HICCMSTLAB_LOCUS6060</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2013" name="Philos. Trans. R. Soc. Lond., B, Biol. Sci." volume="368" first="20130047" last="20130047">
            <title>Functional endogenous viral elements in the genome of the parasitoid wasp Cotesia congregata: insights into the evolutionary dynamics of bracoviruses.</title>
            <authorList>
                <person name="Bezier A."/>
                <person name="Louis F."/>
                <person name="Jancek S."/>
                <person name="Periquet G."/>
                <person name="Theze J."/>
                <person name="Gyapay G."/>
                <person name="Musset K."/>
                <person name="Lesobre J."/>
                <person name="Lenoble P."/>
                <person name="Dupuy C."/>
                <person name="Gundersen-Rindal D."/>
                <person name="Herniou E.A.Drezen.J.M."/>
            </authorList>
            <dbReference type="PubMed" id="23938757"/>
            <dbReference type="DOI" id="10.1098/rstb.2013.0047"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cystatin family.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5092332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5092334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="HF586472">
        <property type="protein sequence ID" value="CCQ71079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S6CVK5"/>
    <dbReference type="OrthoDB" id="6357437at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031982">
        <property type="term" value="C:vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004869">
        <property type="term" value="F:cysteine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00042">
        <property type="entry name" value="CY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000010">
        <property type="entry name" value="Cystatin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046350">
        <property type="entry name" value="Cystatin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46186">
        <property type="entry name" value="CYSTATIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46186:SF2">
        <property type="entry name" value="CYSTATIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00031">
        <property type="entry name" value="Cystatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00043">
        <property type="entry name" value="CY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54403">
        <property type="entry name" value="Cystatin/monellin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0646">Protease inhibitor</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0789">Thiol protease inhibitor</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035395919" evidence="4">
        <location>
            <begin position="25"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="Cystatin" evidence="5">
        <location>
            <begin position="25"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAG5092332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAG5092334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCQ71079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="134" mass="15416" checksum="87E8F299D35E5BC9" modified="2013-10-16" version="1">MGKEYRVAFVLFLGLALLIAEARSSFLGKRQPISVNDSGVIEAAEIIMKRINQEHHGKRALMLVKIERAESQVLYGIKYFLDLKVGERHCLEQNLSRKCKLDKNCPYKSCIAFVYSGLWGSIKESHYNCREYEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>S6D9M4</accession>
    <name>S6D9M4_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cc_single_12.1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">CcBV_12.1</name>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS1414</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Philos. Trans. R. Soc. Lond., B, Biol. Sci." volume="368" first="20130047" last="20130047">
            <title>Functional endogenous viral elements in the genome of the parasitoid wasp Cotesia congregata: insights into the evolutionary dynamics of bracoviruses.</title>
            <authorList>
                <person name="Bezier A."/>
                <person name="Louis F."/>
                <person name="Jancek S."/>
                <person name="Periquet G."/>
                <person name="Theze J."/>
                <person name="Gyapay G."/>
                <person name="Musset K."/>
                <person name="Lesobre J."/>
                <person name="Lenoble P."/>
                <person name="Dupuy C."/>
                <person name="Gundersen-Rindal D."/>
                <person name="Herniou E.A.Drezen.J.M."/>
            </authorList>
            <dbReference type="PubMed" id="23938757"/>
            <dbReference type="DOI" id="10.1098/rstb.2013.0047"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CAJNRD030001116">
        <property type="protein sequence ID" value="CAG5075260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="HF586477">
        <property type="protein sequence ID" value="CCQ71331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S6D9M4"/>
    <dbReference type="OrthoDB" id="10351332at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5075260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCQ71331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="78" mass="9211" checksum="07EF39A1AF33974C" modified="2016-04-13" version="1">MSRRKRGPTKKNKIDSSSISQADFTEEREIQQHHLMFTDLLKPVTSYFEELLIELKQRNMESQATLQNLLNKLTECNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2EAU3</accession>
    <name>A0A8J2EAU3_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HICCMSTLAB_LOCUS727</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001114">
        <property type="protein sequence ID" value="CAG5073955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2EAU3"/>
    <dbReference type="OrthoDB" id="7679028at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052192">
        <property type="entry name" value="Insect_Ionotropic_Sensory_Rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42643">
        <property type="entry name" value="IONOTROPIC RECEPTOR 20A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42643:SF24">
        <property type="entry name" value="IONOTROPIC RECEPTOR 60A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035188166" evidence="10">
        <location>
            <begin position="20"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="342"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="370"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="575"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="607"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="641"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAG5073955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="641" mass="75213" checksum="D17BABB9A3B96300" modified="2022-05-25" version="1" fragment="single">MKGVKEIILCFLFVSVIHCNMIQVYDSSTPKSPAYHIHARKLLELCFPNKLNPVVISAELMDLMYEIQKNETIDSSIIVIDNVFSSKVMNQYYTRHPSYLITAESMDRLQDTLQEMKSSTIWNTASVIVAVGKDCVRASEILQVIWKIEALKSYYICQHELMSDESLVYIFNPYTQRAPKQWEQVETEDQPDDRWTLYRQHLKNDQRICSSVTFDKTRSLDRYSLKGYKYGSYDKVFKGKVSPEAYHEEQEIEHFIHNELFTALNVTPIIYLKNVIHGHFNQNLNLLKNGTYDMILEIVDTPDDDDSEILDIISIYVQNGFMIVTKKQNTIPALTEVTNDSFAYETLTISAIFLLIIFVIILLNSRYNFAVALIDLWLLVLGMGILTPMNRLLIRITFLSATLFVFVVGPELQSQFTSVMTIPSVDKNIETVDELYDNRYNVYYFDDRTWAEIWENKIDNKYLHWIADLKSCFEYLDENSTACIMPDYMFENIKIADLHISKESFRKNYLWLTTRKNFPLKVKIDKTAMNLIETGCINYFERNNRLERQLKTKKLIDRIEAYEQCEFLDLPNFSSFLWCLTIVILVSFSVFLVELVCGIRKYRGKRSRKLKKRIQRVRQRIATLFRQIATHNRNSNITFAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2EBJ4</accession>
    <name>A0A8J2EBJ4_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS992</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001114">
        <property type="protein sequence ID" value="CAG5074268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2EBJ4"/>
    <dbReference type="OrthoDB" id="7677957at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5074268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="116" mass="12633" checksum="C9D096577E8B9AEF" modified="2022-05-25" version="1">MTMKGKGRLHPAYSLSGSEGEDNPRVSGTRGPSQAQSLYSQSQPGQSHSHYNTAHKRGTASYQQPQLYHVASRVEGLSDTPTSGNASDETLTDCELTHLAREWNDTSEPNLEPFVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2EHF7</accession>
    <name>A0A8J2EHF7_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transposase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS108</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030000639">
        <property type="protein sequence ID" value="CAG5071959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2EHF7"/>
    <dbReference type="OrthoDB" id="7694954at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579">
        <property type="entry name" value="F5/8 TYPE C DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579:SF1">
        <property type="entry name" value="F5_8 TYPE C DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5071959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="857" mass="98857" checksum="FD31B03CB798C97E" modified="2022-05-25" version="1">MSESRIFQKGLSSAERRRLSKQIEDHLTVFSHDLSLSLWKGNPEISTPCVQNSSPPQHFDVQDAAHSSQLSNSDLDGERNVSQVDAEDDPAERNFVDEPINEHLLNELSQELEDTEEIEITPSFSTNQFNESALFPLAFKENVSSNDYLVAAMGRLAKYNLPYECILSEFKWMNSTTAIPQLPNSKEQLWKLLSRNDLNYVRHYYCVRCSSPLGSNEKATKNDSELHKKLKRSKTTDYKKCTSETCRGLDSKVSYFIQLKLYPQLHQLLSIPNISKSILYRHTRRKINENALEDIYDGCEYQKLCSSGEFLSNPNNMSFTLNTDGCSVSNSSKASAWPVYLEINELPPHARKRHMLLAGIYCDFDKPVMNNFLVKCMSELNDLYRKGIQWLKSDGTKVESKFVLLMCSVDSIARPPILRMTQFNGDFGCTYCYSRGSTSDNNQLVRYYPASEQIRLRTDKELRLGMLKAFKDNKKVNGVKGISSLISFPKFNLAKGRIVECMHSVYLGVVRQHILLLLDLVDSKFFNHINGRTAAIKPPTRISRLPRPIGEIKNFKASEFRNWLLYYFLVCFDGLLESKYMKHFALLSQAIYYLNQASITLEELHNAEILLDQYVEQFEELFGIENMTFNVHLLKHLPQTIRNWGPMWAHNAFTFESWNHRIMECIISPKDRVLQVVNRFCIMKFICNMSHEDSVSFDTKLYLNSLFPSFHFDDNDRSFIAKGNSTDSVHSCIPPQYSTANCTSYDDARINNIHYRRIDKNPDTQFCNSYVYCKNVRFGCIEDIIELEKDGERINGLIVRKLKVKKNVLNTTYINFVESTSELIFVPSNEVVAPCIVIREIDDCKYIVKLPNTWESD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2EIN7</accession>
    <name>A0A8J2EIN7_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS804</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001114">
        <property type="protein sequence ID" value="CAG5074032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2EIN7"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5074032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="111" mass="12618" checksum="BE52E733AE988F61" modified="2022-05-25" version="1">MCVDTNLLTLEERRICASILLVSGLLSNEIDCPRLLELIPILVPQRNLRSDQPFYPPRQRSNFILTSPINRLINACNYIVQQNSDIDLLGYQTRCSANALASIIINSRQFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2ENM6</accession>
    <name>A0A8J2ENM6_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS1769</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001116">
        <property type="protein sequence ID" value="CAG5075615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2ENM6"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5075615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="70" mass="7961" checksum="18FD35A875777303" modified="2022-05-25" version="1">MGTAKSKTKLTMDNGKKPLSTERTAVYKRNKRRVLRYLKAFPPGTPGPIPKLYLESPRPPFSIKKIFLSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2EPB0</accession>
    <name>A0A8J2EPB0_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Similar to Venom allergen 3 (Solenopsis invicta)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HICCMSTLAB_LOCUS2374</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001117">
        <property type="protein sequence ID" value="CAG5077112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2EPB0"/>
    <dbReference type="OrthoDB" id="43654at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd05380">
        <property type="entry name" value="CAP_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.33.10">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018244">
        <property type="entry name" value="Allrgn_V5/Tpx1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014044">
        <property type="entry name" value="CAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035940">
        <property type="entry name" value="CAP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001283">
        <property type="entry name" value="CRISP-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002413">
        <property type="entry name" value="V5_allergen-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10334">
        <property type="entry name" value="CYSTEINE-RICH SECRETORY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00188">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00838">
        <property type="entry name" value="V5ALLERGEN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00837">
        <property type="entry name" value="V5TPXLIKE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00198">
        <property type="entry name" value="SCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55797">
        <property type="entry name" value="PR-1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01010">
        <property type="entry name" value="CRISP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035147179" evidence="4">
        <location>
            <begin position="26"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="SCP" evidence="5">
        <location>
            <begin position="66"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAG5077112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="249" mass="29103" checksum="68CBF6A071282FFD" modified="2022-05-25" version="1">MILQFGTMKFVLLIWLAAIIKCNEGGEWTYCYPDSCRGERHTLCEYGEWRRGPECNRVITNFVTDEEKREILETHNMLRRKVAAGLETRGNPGPQPRGIIPDLRWDRRLAIIAQAWANQCIFKHDPCRDVKRFRVGQNVGYTGNSSRSFDKLSVIITNYWYDEVANFTNNLVKNYKGEEEEAPVYSHYTAIVWGSTRKIGCGLTRHFTNRSMYRTHLVCNYGPRGNWIGEPMLNIKKIIYLNQNIRRFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H1F9</accession>
    <name>A0A8J2H1F9_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similar to spop: Speckle-type POZ protein (Xenopus tropicalis)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS496</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001114">
        <property type="protein sequence ID" value="CAG5073559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H1F9"/>
    <dbReference type="OrthoDB" id="6418787at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24413">
        <property type="entry name" value="SPECKLE-TYPE POZ PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="163"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="375"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="742"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="1058"/>
            <end position="1125"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1244"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5073559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="1244" mass="141558" checksum="34FB21BDFFF49B29" modified="2022-05-25" version="1" fragment="single">FKMSTENKDGKNVLFQFKHLFTNITTRKSINSPEFDSPKIPGVKFSISADIIYHSNMTVKVIKNDIRKAVSIIKIEVGGLNSTKRVVVDWKDILYFKDLNIPFDFYGCSKYKDFPNFCSQPKRSHVYTVPIICTIIWNGFVEDLYYPNVSTILKILHNNEEFSDIVIKVKKTEFIAHTNIIAAQSPVFYKMLTSDMKESKKNTPGRPDSGPTFDVDTVFISSDPKNLFKFKHALFNLTEKSGLQKSIEFATPKIPGIKFKIHTQINVDTKTMDVTIKKDNPRKFVSIITLKIGGTTRTDRFFDWKKNVFFKNIPLPITSDACPKNHNFVCVPSPDGHKYTVTITCTIIWNGFVEDLYYPDVSTVLEILHNDEECSPIVIKVQETEFIAHKNIIAAHSPVFYKMLTSDMEESNENSMTFPDTEPDVIGELLLFFYKGKMDKAEKDADLALKLFEFAHKYEIERVISTCEYILITKLTKENVSKIHDKGQLYKSVILRQHAITFIEMNATEMRDDAALEMPPNLSCTMPTFTSEILPQSTPFSNATLPFVYNSYSTVGQKYFVPIRRNLGPPPGFPDLRVVFGVNSGCPASEPKNVYKFDHSFLNLTEKSGLQKSPEFATPKIPGIKFKINTQINIDTKTIDVTIKKDDQRKSVSIITLEIGGSTRTDRFCDWTKKVFFNNIPLPITSDSCPKHNNFVCVPSADGHKYTVIVDCSIVWNGFVEDLYYPDVSTILKILHNNEEFNDLVIKVEKTEFKAHKNIIAAQSPVFYKMLTSDMEESKENSITFPDTEPDVIEELLLFFYKGKMDKAEKDAELAIKLFEFAHMYEIKRVISTCEYILITKLTKGNVFKIHDKSQLHKSVILQQHAITFIEMNATEMRDDAALEMPPNLSCTMPTITSEILPQSPPLAPPGFPDPRAVFGVNSGCPASEPKNGYKFNHSFLNLTKKSGLQKSPEFATTKIPGIKFKINTRIYIDTKTIDVTIKKDDQRKSVSIITLEIGISSDACPKNHNFACVPSADGHKYTVIVDCSIVWNGFVEDLYYPDVSTILKILHNNEEFNDIVIKVEKTEFKAHKNIIAAQSPVFYKMLTSDMKESNGNSITFPDTEPDVIEELLLFFYKGKMNKAEKDAELALKLFEFAHVNEIERVKSTCEYILITKLTKENVSKIHDNGQFYKSVILQQHAITFIEMNATEMRDDAALEMPPNLRSTMPTFTSEILQQNPPLGNATLPFGYYDLYSTFGEKYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H2R9</accession>
    <name>A0A8J2H2R9_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Similar to CRAMP1: Protein cramped-like (Homo sapiens)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HICCMSTLAB_LOCUS1614</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001116">
        <property type="protein sequence ID" value="CAG5075460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H2R9"/>
    <dbReference type="OrthoDB" id="515799at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007389">
        <property type="term" value="P:pattern specification process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055315">
        <property type="entry name" value="Cramped-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21677">
        <property type="entry name" value="CRAMPED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21677:SF1">
        <property type="entry name" value="PROTEIN CRAMPED-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="373"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="416"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="550"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="422"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="550"/>
            <end position="561"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG5075460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="823" mass="94075" checksum="599E822D282E4AF5" modified="2022-05-25" version="1">MDKDKEKEDDSTSAIGSAKKDDTVLTLDIKTAVDAKNSQAKIVRGTKKIRVDSTDFNQITDKKDNKEDEGDAKIGKSLKRESERWTLEDKNTFFKAINEYGKDFDGLQGYFLNQGRKKGSSDNMIKNKEQIRHFYYRTWLKISKHLKFSDDLKKTSQEIYGLINYGELRRKLPRIHEKFLLKLNELIYWGSTQVRLRGKTMRIKTPICRALRKLNQLEDWQEEIKLPPRVTVELRPGNNLTWWKVQANAMNPRVRTLVPIQRRLSSLLAFLQQRWQPLKFKPSLNIDDESFYDKKYNDNELLRVTPIEGAKISLPMVNLGEYLTSNSVSLNSYEQRLSLKSSREELLGYVQQFKSVGKKTIKKKIDKKILNLRGAGTGGSTGGEDHDKLNDNNSDLDNLDTHLNCIDKSLFSSHSDKNVGDSSVNSNINVNLNNNSNNNNNNNNNNINNNSSTEPNRFPGRETIDRIRMGWNIEEANTITIGDLFLMFGRESKIVLDYWWDSPKQNDREANDSSLLSKDFKKQDENICLALQKLLSIAKHNYGSNKAFDNTSSSNETVVSSRMPSTKDSTFRRPLIPQVYHKTNSHQAFKTQLDKFTTRFCKRGRTVRQRNLIVQRTVPLIGNMSCETNETNDTNKLNLNVPQKVTEYSNDNNPNDMGVELSNKNENMESDNLLSSFNEVPVDDSNNDLLVQPSNSIITSATQILKEGESQWLNSEVADYSLSSYFLGQLESPLKGSQRSQTGSQLELMRPSSDVLSQMQCLMVENSVDYMAKFANLASQIASNDQNINRQLKARSSLSDPALAIKALDRVRIRRTPMNIFNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H3X1</accession>
    <name>A0A8J2H3X1_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">E3 ubiquitin-protein transferase MAEA</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Macrophage erythroblast attacher</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HICCMSTLAB_LOCUS2221</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001117">
        <property type="protein sequence ID" value="CAG5076567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H3X1"/>
    <dbReference type="OrthoDB" id="1933455at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034657">
        <property type="term" value="C:GID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016363">
        <property type="term" value="C:nuclear matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043249">
        <property type="term" value="P:erythrocyte maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16659">
        <property type="entry name" value="RING-Ubox_Emp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013144">
        <property type="entry name" value="CRA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024964">
        <property type="entry name" value="CTLH/CRA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006595">
        <property type="entry name" value="CTLH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045098">
        <property type="entry name" value="Fyv10_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006594">
        <property type="entry name" value="LisH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044063">
        <property type="entry name" value="ZF_RING_GID"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12170:SF2">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN TRANSFERASE MAEA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12170">
        <property type="entry name" value="MACROPHAGE ERYTHROBLAST ATTACHER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10607">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00757">
        <property type="entry name" value="CRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00668">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00667">
        <property type="entry name" value="LisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50897">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50896">
        <property type="entry name" value="LISH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51867">
        <property type="entry name" value="ZF_RING_GID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0265">Erythrocyte maturation</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CTLH" evidence="11">
        <location>
            <begin position="152"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="RING-Gid-type" evidence="12">
        <location>
            <begin position="307"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="RING-Gid-type" evidence="10">
        <location>
            <begin position="307"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00029678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAG5076567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="359" mass="41283" checksum="4661D154DA733461" modified="2022-05-25" version="1" fragment="single">MSDIKSMEHPTLKVPYELLNKKFRSTQKVLDREVSHVQIAANELEKGINNNNGHATTGEISRLLGGVVAKLQVLKRKAEESISEELQAGMVCKRRLDHLKEHGSSSPSVVNQWRRQRLDRMLVEYFLRKGYYKTAMKLADTTELRELTNIDVFMVSREVEISLANHETARCLGWCHDNRSKLRKLGSTMEFNLRVQEFIELVRADRRLDAVKHARKCFANYDEYQLQEIQSCMGQLAFPANPYLSPYKDLLDEKRWDRLIEQFRHENYRLFQLASQSVFTVALQAGLSALKTLQCYGANKECKNPSCPVCNENLNELASPLPFAHCSQSRLVCSISGEPLNEYNQPMMMPNGYVYGEKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H4W3</accession>
    <name>A0A8J2H4W3_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phorbol-ester/DAG-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS192</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001003">
        <property type="protein sequence ID" value="CAG5072807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H4W3"/>
    <dbReference type="OrthoDB" id="6778678at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="197"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="211"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="237"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5072807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="286" mass="31400" checksum="078D820BC7AA9F4C" modified="2022-05-25" version="1">MSRTCRGCSGSIVNDSVSCPGCASTYHPSCAKSTSVLSNGAFQRCCGVKKSFSYEDLRKLICDESKSTKNEITAGILKVQESVDALSQSVNERINIIEEGQHKLGKKVVTLEGNIKANTDKIKALEEHPPGDESILDEVEDRLARRNNVLLFNLPEPIQSDLEARSEADASLITKICNTLSIDSSSSSLTSQYRVELHTKEEDQPTSPRSGSERRSDDIRSYSTSTPAAQEYPGGVSASSHGRRSQSTTSDKAWQDSNYQHTIASSKSNAERRSILNTTYKQSYIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H5U2</accession>
    <name>A0A8J2H5U2_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Similar to Anks1b: Ankyrin repeat and sterile alpha motif domain-containing protein 1B (Mus musculus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HICCMSTLAB_LOCUS2132</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001117">
        <property type="protein sequence ID" value="CAG5076302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5314041at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01274">
        <property type="entry name" value="PTB_Anks"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09500">
        <property type="entry name" value="SAM_AIDA1AB-like_repeat2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033635">
        <property type="entry name" value="ANKS1/Caskin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006020">
        <property type="entry name" value="PTB/PI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041882">
        <property type="entry name" value="SAM_ANKS1_repeat2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24174">
        <property type="entry name" value="ANKYRIN REPEAT AND STERILE ALPHA MOTIF DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24174:SF1">
        <property type="entry name" value="IP14385P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00640">
        <property type="entry name" value="PID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00536">
        <property type="entry name" value="SAM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07647">
        <property type="entry name" value="SAM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00462">
        <property type="entry name" value="PTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00454">
        <property type="entry name" value="SAM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01179">
        <property type="entry name" value="PID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50105">
        <property type="entry name" value="SAM_DOMAIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="48"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="81"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="117"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="190"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="222"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="SAM" evidence="6">
        <location>
            <begin position="926"/>
            <end position="991"/>
        </location>
    </feature>
    <feature type="domain" description="SAM" evidence="6">
        <location>
            <begin position="998"/>
            <end position="1057"/>
        </location>
    </feature>
    <feature type="domain" description="PID" evidence="5">
        <location>
            <begin position="1201"/>
            <end position="1328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="281"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="409"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="461"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="507"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="747"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="832"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1061"/>
            <end position="1082"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1102"/>
            <end position="1130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1143"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1334"/>
            <end position="1356"/>
        </location>
    </feature>
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        <location>
            <begin position="409"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="472"/>
            <end position="483"/>
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    </feature>
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        <location>
            <begin position="507"/>
            <end position="520"/>
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        <location>
            <begin position="775"/>
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        <location>
            <begin position="1104"/>
            <end position="1130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="1149"/>
            <end position="1158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1346"/>
            <end position="1356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS01179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAG5076302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="1452" mass="159243" checksum="7245D8B0BBB3DBFB" modified="2022-05-25" version="1">MGKDQELLEAARSGNVTIVEKILGQRARRSGPLASLRRGPGANVQDASGYSALHHAALNGHKDVVKLLLQHEASTNVVDAKGSSPLHLAAWAGDAEIVRLILSQGPSVPNVNLTTKDNETALHCAAQYGHTEVVAQLLQYGCDPSIRNSRGESALDLAAQYGRLETVQLIVRTHPELIEPLRNSSSSLIFPHTPLHLASRNGHRAVVEVLLASGVDVNTRTSAGTAMHEAALCGKMEVVRTLLDRGVDLGIRDARHNTVLDLLGQFPPHVTHDITAVIKRHRSSSGIESDADGEHIPQTNDILGSPYDNALDLSPVEGSSPTQWQFYHKPRDEDRRVSGTSVMSFGDFEGNIYYDASELQVTESYSDPSSFFDSVLMSISDTLNSINTLASSVQTTPDDNNKFIDISINKNNNNNSNNNNNNTSVSPRTRGSDSGLYQTPPAPRCTEGSYVSEDLSLTLPAGFTGRESDQLSVSSSSSIGGPSPRDRRCLPNDSGISGIYLPMAPLSSSLHSPASNSKVSPTPPKKPPRRNLSVSPTHLQTQMSLSADCSLGPSNYEYLFLARSGARSHIDLEQLQTRRDQLRHVTRSVDQYVDMKARYSGPESINRRAGEEPVALTAVYGDRLIKLQNPRRKLRRHCERAYENYDVDNNAPVDQSPTSETLHDQTFVSNAFLTLKSSQESLLDDRKDNGDLTEELKTAGAGEATDKRLKRVQMLIPTSPTHYIQPPTPDHPPPSALQAEKSIHERIRPLSQIYKRRSRDMETETEEDLLQFQPSGSLDASSGSLSSVSLSDKSMSNDNVEEYFGDVPFAGLLKGSVTAERPRTLRRLRNVYTGNSGMGTGSTDSSNERIIDNANADPLLREKDRDRDEKSLSIMSPFDEQEEWAKISEIMASFGTGLVRESVFVNELEKEFQSRLGIGCETNSPTVTTTIGQWLLNLGFADYESLFLNYGFDDLEFINGVLEESDLKDMGITSDTERAVIMNASLLLNKRVDKRSGSQAKTVEEWLKGINLDNYLETFKKHLYTDMDRVKRVWEVELAAVLEIQKPGHRKRILASVTGPTPRSLALATNGRPPNLDDINKDLNNLKTNIQQLKEEIRDKLPETQNSQNSQNSQNNGNPPTTQNSSTTVVTGTNAVTMGTLRHRKNRPAPQPPHPPQRPQNGTPSAEQLEIRAPSELLFGVPSTLKTQWRHQPKVLVTGNITYVANYLGSTVVKELRGTESTKKSIQKLKNTCRDPRVSLAITLAISYRGVRFLDTNTNEPICDHEIRNIHCACQDADDLTHFAYITKDHASRTHFCHVFCVSTMDQATEVILTLGQAFEVAYQMALKDKLTGTGTGNGNSQTVRSHTNVNTNSNSNSHCNINMSTNSHTGINVTVGSNCTSSGNSNANTKGGPVPVPPKPLVTHGRSHSVNDIKINGNQLKLVPTPVDDIGIGVKDMKAGSRAPIALSEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H676</accession>
    <name>A0A8J2H676_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS2671</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001117">
        <property type="protein sequence ID" value="CAG5078200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H676"/>
    <dbReference type="OrthoDB" id="8189012at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012464">
        <property type="entry name" value="DUF1676"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21879:SF22">
        <property type="entry name" value="FI03362P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21879">
        <property type="entry name" value="FI03362P-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07898">
        <property type="entry name" value="DUF1676"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="170"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="195"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="233"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="72"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="235"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="246"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5078200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="260" mass="28889" checksum="C3AA1FED03D42E2B" modified="2022-05-25" version="1">MWQELITLYVLYKNDTFMDNRPVSGVLSSNMMLQDIRVCALLIVFLYGFIGGSYSEPAFRRHRTLNYQLSSNNNNHNNDNNNHNSKSFDKANDSKVTVDCVGSRADSPECKLLVKSRNDTIGSNGTIDRFKDSNEEDSDQNQSLIAEVFGDGDDSALEEGRGRKKKKGKAGIFFMVAAAMKATLLWVMVHATALLAGKAFVIAKIALALAAAVALKKSLDHGEKTSYEIIKHPQHSYASSHSSSIDYDHHGGFEGHRRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H6E6</accession>
    <name>A0A8J2H6E6_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="19">Similar to nrv2: Sodium/potassium-transporting ATPase subunit beta-2 (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">HICCMSTLAB_LOCUS2797</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="17">This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the X(+)/potassium ATPases subunit beta family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001117">
        <property type="protein sequence ID" value="CAG5078638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H6E6"/>
    <dbReference type="OrthoDB" id="5912413at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005890">
        <property type="term" value="C:sodium:potassium-exchanging ATPase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001671">
        <property type="term" value="F:ATPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030007">
        <property type="term" value="P:intracellular potassium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006883">
        <property type="term" value="P:intracellular sodium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990573">
        <property type="term" value="P:potassium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036376">
        <property type="term" value="P:sodium ion export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1660:FF:000004">
        <property type="entry name" value="sodium/potassium-transporting ATPase subunit beta-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1660">
        <property type="entry name" value="Na, k-atpase alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000402">
        <property type="entry name" value="Na/K_ATPase_sub_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038702">
        <property type="entry name" value="Na/K_ATPase_sub_beta_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11523">
        <property type="entry name" value="SODIUM/POTASSIUM-DEPENDENT ATPASE BETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11523:SF46">
        <property type="entry name" value="SODIUM_POTASSIUM-TRANSPORTING ATPASE SUBUNIT BETA-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00287">
        <property type="entry name" value="Na_K-ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="14" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="15" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="13 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0630">Potassium</keyword>
    <keyword evidence="5" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="11" id="KW-0915">Sodium</keyword>
    <keyword evidence="16" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="6" id="KW-0740">Sodium/potassium transport</keyword>
    <keyword evidence="7 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 18" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="95"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00025540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="CAG5078638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="361" mass="42053" checksum="6C2456945344888C" modified="2022-05-25" version="1">MNICKEDNHVVCLVDNNILILELNVLNRGLRIMWLVGKGQTKIKVDEKIGRQYEDDYMRIPVFKSKIKAFSDFFYNPNEKTVLGKTKKQWGVTGLFYLVFFSGLIVLFSICMVGLMATIQKDKPRWTLDQSLIGSSPGLGFRPISDNPHELALIFYKNNNETQIKTWTRRLDDYLEHYRNRTMLPNRQRCDYKFPKPKEGNVCAVDLDTDFGICSPSNQYGFNNSSPCVFIKLNKIFDWVPEYYQLSELPSDMPKKLVNHIKSYGNSSELNTVWVSCQGEEAEDRESLGPIQYFPKIQGFPGYYYPYKNINGYLSPLVAVNFERPTRNKIINVECRAWAKNIIFHQRQKIGMVHFELRIDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H755</accession>
    <name>A0A8J2H755_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS3246</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5081311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H755"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5081311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="354" mass="40470" checksum="3383094FA60E898F" modified="2022-05-25" version="1">MAQVIFTSFTRTVDKIKTVDRSVKLTNKTTKKIISNDHSITTTTNGVVTIDRTFEKFDLDGNVDLHDHFFNISSGDTVITGRNLTRLTNFRTKDVDFLESARKRDGELTISRSFVSFPMDNTPVNTSNVAIAIKANNLTEIYHRNTLMINDETIWKKVGSNATAIITEKGIQLIDFRFKKFNQDNEVSVSKQTQVELQTDNSIIIDTYTSSTNFLTSGFRLPEVEDHFILTIKADDQKTVDQYITTKRQLGDTYDIISFEMFNATIEADETVSKIQTNLRMDPSEHRLYLQEMIRKAKLRITTDLEEVIATSISMTNTVTTMTEMYQSIFRDIGTFNQILCQFTLKFSLRAVDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H7B2</accession>
    <name>A0A8J2H7B2_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Transcription initiation factor IIE subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HICCMSTLAB_LOCUS3310</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="6 7">Recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Tetramer of two alpha and two beta chains.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the TFIIE beta subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5081532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H7B2"/>
    <dbReference type="OrthoDB" id="5323195at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005673">
        <property type="term" value="C:transcription factor TFIIE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001097">
        <property type="term" value="F:TFIIH-class transcription factor complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07977">
        <property type="entry name" value="TFIIE_beta_winged_helix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000177">
        <property type="entry name" value="Transcription initiation factor IIE subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040501">
        <property type="entry name" value="TFA2_Winged_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016656">
        <property type="entry name" value="TFIIE-bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003166">
        <property type="entry name" value="TFIIE_bsu_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12716:SF8">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIE SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12716">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIE, BETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18121">
        <property type="entry name" value="TFA2_Winged_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02186">
        <property type="entry name" value="TFIIE_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016398">
        <property type="entry name" value="TFIIE-beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51351">
        <property type="entry name" value="TFIIE_BETA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 7" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="TFIIE beta" evidence="9">
        <location>
            <begin position="63"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="21"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="245"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="26"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="253"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="270"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR016398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAG5081532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="287" mass="33248" checksum="D52CA5A6F53D847F" modified="2022-05-25" version="1">MSTKMDPALLQQRELFKKRAIATPTVEKKKREKETERDDAVLKKPKVSSSSSASKIDTTSYKTTTGSSQYKFSVLAKIVKHLKTKYQENDDYPLSLDEILDETNQLDVGSKVKQWLQTEALAQNPKIEMLQDGRFIFKPTYKIKDRKSLLKLLKQQDLKGLGGILLDDIQESLPQCEKYFKNLQNEIIVVQRPLDKKKVIFYHDKMDNIQIDEDFQKLWRSVPVDAIDDQKIDEHLEKQGIAKLSDHGLKKAPPIKRKKAANKRKHLKKPRDNEHMADLLETYGDDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H7C5</accession>
    <name>A0A8J2H7C5_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Olfactory receptor 77</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS3426</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5081976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H7C5"/>
    <dbReference type="OrthoDB" id="6617147at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0675">Receptor</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="126"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="157"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5081976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="275" mass="32089" checksum="8701E1615B89D95A" modified="2022-05-25" version="1" fragment="single">MRVWPLVPNYYLFYFHVLCFSYAIILQVIDLYESINDVDKLIDNFTENLASTIVYVRIVMLRVHNYQTGKLLSQVIEDYNASVFKNSYEIKVFMKYVNKGRFMLKRLSIFIVSSEFFYSLDPLNNQTVFIMLYTIYCLWEVNISTRYYLTYLPLGFLAFYMVFGGSTVDYILISLAFSIKNGKLTVLTVRINALYGGLDCRKKLNKIIAEHSRLLKSPNCCKAFSEYSWCTLTIDCGKDFLYCIKRSQKLLGLDAGKFTTYSLIALTVVSKFYYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H7Z5</accession>
    <name>A0A8J2H7Z5_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Fatty acyl-CoA reductase</fullName>
            <ecNumber evidence="10">1.2.1.84</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HICCMSTLAB_LOCUS3500</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the reduction of fatty acyl-CoA to fatty alcohols.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a long-chain fatty acyl-CoA + 2 NADPH + 2 H(+) = a long-chain primary fatty alcohol + 2 NADP(+) + CoA</text>
            <dbReference type="Rhea" id="RHEA:52716"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:77396"/>
            <dbReference type="ChEBI" id="CHEBI:83139"/>
            <dbReference type="EC" id="1.2.1.84"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the fatty acyl-CoA reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.84" evidence="10"/>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5082244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H7Z5"/>
    <dbReference type="OrthoDB" id="429813at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102965">
        <property type="term" value="F:alcohol-forming long-chain fatty acyl-CoA reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080019">
        <property type="term" value="F:alcohol-forming very long-chain fatty acyl-CoA reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035336">
        <property type="term" value="P:long-chain fatty-acyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05236">
        <property type="entry name" value="FAR-N_SDR_e"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd09071">
        <property type="entry name" value="FAR_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000143">
        <property type="entry name" value="Fatty acyl-CoA reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026055">
        <property type="entry name" value="FAR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033640">
        <property type="entry name" value="FAR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013120">
        <property type="entry name" value="FAR_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11011:SF60">
        <property type="entry name" value="FATTY ACYL-COA REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11011">
        <property type="entry name" value="MALE STERILITY PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07993">
        <property type="entry name" value="NAD_binding_4"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03015">
        <property type="entry name" value="Sterile"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="7 10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 10" id="KW-0521">NADP</keyword>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="367"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="485"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="domain" description="Thioester reductase (TE)" evidence="12">
        <location>
            <begin position="53"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="Thioester reductase (TE)" evidence="12">
        <location>
            <begin position="87"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="domain" description="Fatty acyl-CoA reductase C-terminal" evidence="11">
        <location>
            <begin position="372"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="domain" description="Thioester reductase (TE)" evidence="12">
        <location>
            <begin position="549"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="domain" description="Fatty acyl-CoA reductase C-terminal" evidence="11">
        <location>
            <begin position="893"/>
            <end position="985"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00052530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF03015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF07993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAG5082244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="1033" mass="118218" checksum="0560F17156A88DF2" modified="2022-05-25" version="1">MVEALLESGGQEVAVADNGSRAGTPTECSPQISQLDINLTPIQEFYAGQSIFITGGTGFLGKLIIEKLLRSCSNLSVIYLLVQQPKFRHKIVAIEGDCSVPNLGISETDRITLINHVSIVFHVAATLSFDEKIKLAVSINIQSLRDMISLSKKMSKLKSFVHVSTAYAYCTEKKIEEKLYTPPIDADKLVSLMNCVDNNIADKLTPHLLGRWPNTYAYTKAIAENVVEKEAVGLPIGIFRPAIVISTYLEPIKGWIDNFYGPTGVAAGAGTGLLRSLHCDGSVHANVVPGDMVVNALIASAYDVMEEYNHQKSEQTIPVYNYVSQDNAISYNQLKDMSAKYGVNYPTMRAIWYYGFTNNKYKIVHLFYIYFLHLLPALLVDAATLCMGKRPRLLKVYKKIHRFMNVLNYFSTQQWSFTNERLNSLVNRLDPRDKDLFFCDIKELDWNEYFKTYLVGIRVYLIKDPLDTLPQARIKWQRLYWMHQFVKLVIFYLIIKFLWNLLTFMEINVYENDININENNNNILNRINTEQVITRTPIQDFYAGRNIFITGASGFLGKTMIEKLLRICPEVSTIYILMRPKKKSNIIDRIEDIFNEPIFEDLKNNSPKLRHKIVAIPGDCSFPDLGLTLEDRKKIIEEVSVVFHNAATVKFEEKLKVATTINAGGTLSVINLCKEIKNLKAMIHVSTAYANCHLDTIDEQFYPHPLKYEDLRVIVDSLPDETINAVLPSLLEKWPNTYTYTKALAESVVREKSQDLPIGIFRPSIIISCADDPLPGWIDNYYGPTGVIAAAAVGFLRSIRINRDIYANMVPVDYTVNAILASAWDVATHPDRRGENMLIYNYTSTVENPITWGFYIDNCLAFARDYPLKQSIWYLTMTTSQSKVINFLANIILHLLPALLADILMVCRGHKPHVVKSVTKINKFLNVIQPFMLKHWSFKNDNVQRLWSRLDSKDKLSLRFSFDDFDWRNYLRNHMKGVRLFLFKEDPNSLESARKRLRSLRWIHEAVKIAMGFFIKLLNIEFLYLVRSNTENV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H839</accession>
    <name>A0A8J2H839_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">phosphatidylinositol-3,4-bisphosphate 4-phosphatase</fullName>
            <ecNumber evidence="3">3.1.3.66</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HICCMSTLAB_LOCUS3575</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="pathway">
        <text evidence="1">Signal transduction; phosphatidylinositol signaling pathway.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the inositol 3,4-bisphosphate 4-phosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.66" evidence="3"/>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5082484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="159395at2759"/>
    <dbReference type="UniPathway" id="UPA00944"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016316">
        <property type="term" value="F:phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039034">
        <property type="entry name" value="INPP4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12187">
        <property type="entry name" value="AGAP000124-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12187:SF11">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-3,4-BISPHOSPHATE 4-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="7">
        <location>
            <begin position="78"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="8">
        <location>
            <begin position="183"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="330"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="738"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="901"/>
            <end position="920"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="334"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="756"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="782"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAG5082484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="1325" mass="150200" checksum="01323FF3609F125D" modified="2022-05-25" version="1" fragment="single">GQVKMRFNKQELMTLATQPSQKFEKEGILCIKERQEGFFRRTESTGKKLERKRQKGKTHKTLRNLSCVSASTSKVSLERWCRLRGNLLFYFKSKEQWSEPMGVIILEQCSYRIDPPTSQIPYGFSIVFEGGLYQQLGANSSEERDAWLQALQLASYEFMRNQLLALRERIESSSGHKNDTDIHMLRLQRGIETDPAEIPVCEISLSCDNLLCDGHGRPPNPVLEIDVQVAKSLTWIKYARTEVVERSSNPGFLTTVSFRPSDGLNTDTKVKITAYDVRERVSQTATPIGSACVTFSEVQDTPRLRIPLKSAKTTTVGFLTINVWSLEADDKGNSTESTPSRNIPSTNNPGYCHRRSQSLPPRLGTKMKLPHQGQLKLLFANPYVQTYRFHSGLGGDICVHEIMAESKLCFEFPQQLLGIWIQEEKELLQEVAGMGELREPWHTKQVELLDRHLHLLHLYSQAKENLAAFKASYFKRSSRKNDRTLEFAPLNLHLQRMWVHNDTLNKCGFYDFVSVGAFTAHSHKSKNGGLLRLVQALKESPTRHSQLYQGTSKITMAHDAIQAIKQLRRDVVEAMRSLMKLAKEKQTSGMLPICEDMISKTRILLSLWDPGLVEEALTFLEEYKVAKLPEETKNHNEESLTLSLHCNKSLSPFKRITQQLNFDLKSPDFDDLITPDTPECIQDMWSKESTRTKYAGSIGCRNNESNNPDYNNHEAIATNENFVIFPEVEDDCKNTLDNEKDTEEEEPDNNINTNERSNDADRECSPKVGKEIVREEEKEPKEELEEEEEEEEEEDGRANGELDLSKRFLDTKKMCNSPSANYYKPTDEPEPWDLTQLNIEASVMCLVSKVKFLCGRCSSPAVRLRNKNGMPRTQPLRACLPANRVPSNVVTIQPKNDLKSEESSKLLDSSNSLQRLPSQASGADEATAGFAKAKDVCQAVDSMTRVIKNSGQRNKFTEGLDFASIVDWTSELRPSMKKLRQAMDGLLKTARLTHSVFRVQEDAKIAQRSCNVRYRRDVCFSQALTALVTGLMAKLWCQRPDPLFLLILTTLGPLVSFEALLSYYGDEIDMWGDMAVAVEDLHTVTFTLTRCGLPHSKIDDKNLVNPQLPMPRVVGSRAALTVILPVPDGIYSLLPLPQSSRQTLAFNITPVFFNVGINELATLAESLGNTKPQEKSNIDNFDRLNEYYLRFKKLNLPMETNSSRHMMSALKTSVHAKVSKNTDILQLSSQICRRMKGLRFTSCKSAKDRTGMSITLEQVNILATEYHLSENEYARALDCMRSEGCRRENTWKNIGIRKYAFNSIQIMTLPKAYRPPTGTYGSAQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H8B9</accession>
    <name>A0A8J2H8B9_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS3831</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5083408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H8B9"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5083408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="438" mass="51528" checksum="CB6ABF6CCBA85F16" modified="2022-05-25" version="1">MYFNEIPYFFLLLPIILYIFSIDFTEIIFKKYCYNKMIKIKLFMDCGLETLVLRYPILANLFIYLFQISGSGHSSFETTSKHCVNWVNTSTTDTLKRACSLLFMNSFKKGSTRLTFGQSKNTIDEVILLFFNYAERTGFESRLVFNLFIFLSRNYFPVSPLHNERLEPGWVLRNCAFVRWNVLDVVGVEPFHPEVEVHVLGRLAPSVLLVLLEGVLHVHCEDGGQLTDVQLLRELIEHRTVAVLVFLYHRDNQRDQLVPEVQGVQDRAVVIRIPLSFVRVHLELPVVQLVAVLEQELVRRPQASFHAVFHHCASSWWTRQLLDLHSEEGYARQQVHRALQVLQLLWSGCWEVVSEHRQINTQRVVQLVQKFHEFFFLSLKFIWLMNFWKIYLKKILEEILNSKLRTNFLKQTILKSLNVYHFQTNSPILLNFEFNATL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H8L1</accession>
    <name>A0A8J2H8L1_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Similar to slc24a5: Sodium/potassium/calcium exchanger 5 (Danio rerio)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HICCMSTLAB_LOCUS3143</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. SLC24A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5080929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H8L1"/>
    <dbReference type="OrthoDB" id="2127281at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005262">
        <property type="term" value="F:calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008273">
        <property type="term" value="F:calcium, potassium:sodium antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1420.30:FF:000015">
        <property type="entry name" value="sodium/potassium/calcium exchanger 5 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1420.30">
        <property type="entry name" value="NCX, central ion-binding region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004481">
        <property type="entry name" value="K/Na/Ca-exchanger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004837">
        <property type="entry name" value="NaCa_Exmemb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044880">
        <property type="entry name" value="NCX_ion-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10846">
        <property type="entry name" value="SODIUM/POTASSIUM/CALCIUM EXCHANGER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10846:SF70">
        <property type="entry name" value="ZYDECO, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01699">
        <property type="entry name" value="Na_Ca_ex"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0050">Antiport</keyword>
    <keyword evidence="4" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="4" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="33"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="74"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="104"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="142"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="164"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="302"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="332"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="374"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="403"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="9">
        <location>
            <begin position="39"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="9">
        <location>
            <begin position="317"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAG5080929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="439" mass="48460" checksum="200AFEB4F2840AFC" modified="2022-05-25" version="1">MDTSDLGGGVNCTPPAIEDFPHDLFDEKQRQEGAVVVHVIVSLYLFIALAVVCDKFFVPAVEKICHALSMSKDVAGATFMAAATSAPELFVNAIGTFITEGDIGVGTIVGSAVFNILAVPACCGIGAGMVVPLDWWPVSRDCLAYGVTVAILICIIHDERVEWYEALCLVLLYIVYIAVMYWDKSFQRCTRFRTKTSVSSAEDVHIGPGDAGEIHLSRSDKLQSSGDRVEQIATIDVPLQNGGTKSQEENHEAEYEYELLVWPARGGWIRKTAWVLTWPIHLVFMCTIPDCEKPRFKRWFPVTFLMCIVWIGSLSYVVAWMITIIGHGSMGISNSIGSNTFDILLCLGLPWLIKSSFSPTQPGRHYISINSGGLEYSAISLLSTLLLLYIAFASNKFQLDLKVGRACLCMYAVFLILASLIELNVFFRVNLPTCQRTVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H9J0</accession>
    <name>A0A8J2H9J0_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to alpha-Man-IIa: Alpha-mannosidase 2 (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS3798</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5083303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H9J0"/>
    <dbReference type="OrthoDB" id="10261055at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004559">
        <property type="term" value="F:alpha-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006013">
        <property type="term" value="P:mannose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.50">
        <property type="entry name" value="Glycoside hydrolase family 38, central domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015341">
        <property type="entry name" value="Glyco_hydro_38_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037094">
        <property type="entry name" value="Glyco_hydro_38_cen_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028995">
        <property type="entry name" value="Glyco_hydro_57/38_cen_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09261">
        <property type="entry name" value="Alpha-mann_mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88688">
        <property type="entry name" value="Families 57/38 glycoside transferase middle domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycoside hydrolase family 38 central" evidence="2">
        <location>
            <begin position="2"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5083303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="102" mass="11345" checksum="DA8EB5E03663625F" modified="2022-05-25" version="1">MDEARQWHSLFQHHDGVTGTARDSVVVDYAKKMIAALDYLGDITQKSAANLLSSILKAEKSEKNLLKPILKAEKSEKDLLSLNITQKSAANLLNRILKPEKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H9Z3</accession>
    <name>A0A8J2H9Z3_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">3-phosphoinositide-dependent protein kinase 1</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">HICCMSTLAB_LOCUS4407</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PDPK1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5087052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H9Z3"/>
    <dbReference type="OrthoDB" id="347657at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901701">
        <property type="term" value="P:cellular response to oxygen-containing compound"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048638">
        <property type="term" value="P:regulation of developmental growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01262">
        <property type="entry name" value="PH_PDK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05581">
        <property type="entry name" value="STKc_PDK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000163">
        <property type="entry name" value="3-phosphoinositide-dependent protein kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000191">
        <property type="entry name" value="3-phosphoinositide-dependent protein kinase 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000324">
        <property type="entry name" value="Phosphoinositide-dependent kinase 1, isoform F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033931">
        <property type="entry name" value="PDK1-typ_PH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039046">
        <property type="entry name" value="PDPK1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050236">
        <property type="entry name" value="Ser_Thr_kinase_AGC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24356:SF163">
        <property type="entry name" value="3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24356">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14593">
        <property type="entry name" value="PH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="10 17" id="KW-0418">Kinase</keyword>
    <keyword evidence="9 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="16">
        <location>
            <begin position="117"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="273"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="273"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="146"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CAG5087052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="616" mass="70386" checksum="8CBA9F52A7F0A184" modified="2022-05-25" version="1">MLKSIMSWHNSRYLEHTTAKKYRGQISACFDQFRRQILSRVANQTLSVSTQPAVTVEGPVSKMSPPTNDVTSVVAAAAAPPPPPPPPNNNLPRVNPANPANPAINTFQNHKRTANDFIFGKVVGEGSFSTVYIAKDIHTNREYAIKVCEKRHIIKEKKTEYVKREKEVLNMLAGARHSFVRLFCTFQDVDRLYFVLSYAKNGELLPYINKVGSFDIECTKFYSAEILRGLEYLHGLGIIHRDLKPENILLDEKMHILITDFGSAKILKEDPEQLNTSAKTISSRGSSESDQERPRRRERRNSFVGTAQYVSPEILTDKPASRASDLWALGCIIYQMVSGLPPFYSKSEYLIFQQILKLDYEIPDGFCPLAKSLVSQLLIIEQTERLGAIDEHGSGYPSIRAHPFFEGVDFETLHEQVPPSIYPYLPGTSEHEEMRSHYRVPDHLEPGLDDKQLTRLLGLGIGQETQEKPAPVISVVKKPKQKSSSSIVDLTPGEFQSRLELQRTTNQWHPFVDHQVILKQGFINKRKGLFARRRMLLLTTGPHLFYVDPFNMVLKGEIPWSKELRVEPKNFKIFFVHTPDRTYYLEDPEGFALEWCRVIEEMRVHYYGLQESKKSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HAH9</accession>
    <name>A0A8J2HAH9_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS5135</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5089187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HAH9"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5089187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="107" mass="12307" checksum="C625602C635B7676" modified="2022-05-25" version="1">MFIKDTTVNLDLTFCFRFVYSDNRARNHPFCISDDNTPVWLLRLETFTVTVSLGIFNLRDQGNVGFAANARRHVEFQWDTTTTPRRGAISRMPSFLFSLLSCSLLPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HAS9</accession>
    <name>A0A8J2HAS9_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS5376</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5089788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HAS9"/>
    <dbReference type="OrthoDB" id="10021598at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36696">
        <property type="entry name" value="AGAP012002-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36696:SF1">
        <property type="entry name" value="EF-HAND DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="224"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="224"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="257"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5089788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="478" mass="53861" checksum="B2E0036A0FC45B79" modified="2022-05-25" version="1">MSGISSNTGLIAARVTPVYRTKSKKLELLSIAKPAPFTIRPFAGLFNPFPYGCSVLCNHPADCEAKEFIRRAKESWAMEGKALLLPAEMEMIRATLIAGGIIDSGEVNDGINIHTSTAVPEELFRKYTETDSRPLTPTPTLASGPLTAHQNHPDNLVPCNPRERTTLILDLRTASQEQDETLSWHALTLEPPPSPKRANEYLKSPVQHRHQSRAILPPVQTIPIRRRGKRLKKRRCRRGSAYGQQNEVRDPLEPAETQVSQVDDTSRRNSSLTPHGNVEVENVAEKIPTSLPTQPVFCKTNQIIKSSSRQPHLQRLATSAPRVFSRQSARFELLNSGSLSSIKPLDYLEKHVFITPGRKLIFGRTFNKYYEDSLDETRCISPNDFLEALREVMGSCLTDEKIDQLKEIFGEITEPLSFRRWCGICAASERLLSPLSPKELDPPVWLEKADFEALEKRLINADNVDPKLAYMLRQIRDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HAW4</accession>
    <name>A0A8J2HAW4_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Similar to OSCP1: Protein OSCP1 (Bos taurus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS6041</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5092315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HAW4"/>
    <dbReference type="OrthoDB" id="2157380at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019332">
        <property type="entry name" value="OSCP1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21439">
        <property type="entry name" value="OXIDORED-NITRO DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21439:SF0">
        <property type="entry name" value="PROTEIN OSCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10188">
        <property type="entry name" value="Oscp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5092315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="360" mass="41090" checksum="BA96D191FA30065B" modified="2022-05-25" version="1">MSLHCNPLIYLNMGGEMLYVLQQRLKAQKINSRKTSTVLDDITAALVDPKIISAIFTDSRISSLSWIRSTLEKIALCSIMRLDQDSMNKLFDLMMMMVKFQLSTATGPREIILLTLNHVDGLRNMTSRNGIHEKITVVHELIIKKYGKLTCNEIWDARNECLDLLEDINVRVSILLKLGLQNEDTSFNMNARNYNEKFDLMSKELGSTELLQVPQNLRVGSLQLMGERVTFLGRNIYAMNYSFVTIKPQKEKLPPSNRDKLFIKDKGTKAELGMLAAQLGTEDTSSTRTFSLDLFDDIDVKSEDQDNETSEIKDDDQLEINDMIKINDEYKSKLENLCADFLTEDGIENKVNLLQLLDEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HAY3</accession>
    <name>A0A8J2HAY3_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PAX-interacting protein 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">PAX transactivation activation domain-interacting protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HICCMSTLAB_LOCUS4888</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5088543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="342264at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17744">
        <property type="entry name" value="BRCT_MDC1_rpt1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051579">
        <property type="entry name" value="DDR_Transcriptional_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23196">
        <property type="entry name" value="PAX TRANSCRIPTION ACTIVATION DOMAIN INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23196:SF1">
        <property type="entry name" value="PAX-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16770">
        <property type="entry name" value="RTT107_BRCT_5"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00292">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BRCT" evidence="8">
        <location>
            <begin position="414"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="8">
        <location>
            <begin position="1176"/>
            <end position="1237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="113"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="739"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="904"/>
            <end position="936"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1003"/>
            <end position="1076"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1096"/>
            <end position="1123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1361"/>
            <end position="1388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1647"/>
            <end position="1683"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="1925"/>
            <end position="1952"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="116"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="799"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="913"/>
            <end position="923"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1003"/>
            <end position="1014"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1020"/>
            <end position="1029"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1039"/>
            <end position="1062"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1063"/>
            <end position="1076"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1097"/>
            <end position="1123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1364"/>
            <end position="1379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00030146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAG5088543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="2127" mass="239719" checksum="2B595C46BC1FE49D" modified="2022-05-25" version="1">MSSKVPKLSIKIDTILSKEMESKFGVSENSESAKDIFDNAVKNSDDVTKSTIVTENRCLSNADKNIIDQLNDILSDDINFFPSEEVKSTPSPNPYNNYENLESFYLDYLERDDSPVDASSSAPSEASNSSLQLQGKQKCSMKEFCSCPLYDTQCSNTFSTQIYTSNEIFENHYINEEFLDEDFFFDTDNNSPKNDSEITSELTVSVVKLSDREILSHVSSEIPKSVENNNKNNNSGLSKELRVVLKKITEEEINKYGHGNAKNNNSSNKNMEICSSKELKVLLTRITDIKSSKLVEEKKNTLYAIQDSEFYQENNSEDLYFDHSCYELQETIKMQLKKKKTRYERKRKIEKNFDDKLKNGKVLVYDGNMSDLNDNEIVVHRKELTPLEEYTGTIVLIKNETILKRSARIYTSTIYKILFAGKYAYNDNYKQTIENFGGKVVSDPKVATVLVAKKVKRTMEFLSAICRGIPIVSLNWIQDCVENHRFVDPNKYLLKNVESEEKYNFNLKMSLKRAREKNLFEGYCFIITSGIQEKSFDQLKYCISFLFNHPSLIEGIINSNKSNESQSLVQQNSVDSASADNPQDMCEKYEADCQKKITNSSNILPSLIIRNQKTDCSNEDETNKSLMLVENNKPSIIQHQVSNTTVTTTQKNQFYIINNPYIKPIQSEFSESTNKCSQSKDILKRVTPKKKNLPKIVIENVNSNSQNIPPKLLLYNPHNRISIPINGIVSSTPVAREKKSEGASLKNNNNNVLESDKRNNTSFTRESVSKKMNKNIDDKVTESPTIVQVESSKEISHAANVTNTPTSDKTATLNTTVNSSPKEGTTTIGSTSSNLSQTTVTEPGNSRSTQTISFNKKNNTSSISAPTPNFQKTIPVPEKSNTILMSSIGVQTDPEQNSVAKNLKRKATDDNAQDATASCSHNQGAPPAKKQKIQSSEEVSDVIIHLDGKSANRIEISNELLENGQERQIVSQFFEKISSVVIVQPPSITQSIVKIINKSLRSTNQNSAANNETLRTVGDNNISNNNETSLNKDSRQENSENQEAASSNEPVNSNEKPTNNDSNINERSMNENLNNNQTLNKSIVNEKLNDKSHLAKENSNNTNLNANIKIQRNEPVASTSTAPVETQTVNQNFKSENNFGSSFSPSGFVQYGTRLLNKTDKICFTGEMDEKRQIAIEKLGGQITNDPTDATVLVADKFRRTFKFICAICRSIPIVSTQWINESITKNNFVNPYKYILKDEEAEKNYGFNLEESLMKAKKKQLFRDYTVLITNGVNRPSVNELRTIVKFAGGRPLVRAPKYWGPKSMIISCDDDAPKSKSKKELKIETKKSLEAEKNKRQKTEIMGSAIEKLASNFRGVNKDINNDSTGVNGKNQGSLRPSTPGPIERPKKIHKEKNQVDNREAFKRVEIEETLITKQSKLLIKKGPDDKIVVARQTQTTEQSTKFTKSYLNGDPLEEVSSTTQDDQSSLINVANNLDKVSDNSNENLSLKNDLKTYKNAQRVIGLNDTSESDSTILLMPCHLKKKKKSKNSKNNLSKNKKLALNNTKVNSLENKESKIIKSVDLLSDSDQKNNPPLSKEDLVNKKMGCKIQDEDVTDSESTLSSTPIESQNITTIDSVNDSDTTVFLTPVEQNTSVVNNTHEVDSDSTIFLTPTDKPKNCKKKMKETSSESSEEPPKKKSKNIQTCEKVNQLNESIYKVPEKFSSKEFKEKFIKIVKEEKLKKKIVAVFKHGGPAQTETLPTSSQELKDKLDKILGDEGLVDNNKEPKIDELREKFSEMFGDDVLKSQIEPPPTLSNEEVLNILKPNQHVNTTVDTSLSERDLAVDKKENSRVNKSKVEKKKSWKINGEKLFRKTIQERYVKNSKVGEEKEEMEDTLKLLDESLSLNKNENSVINKSKAEKKKSLKINGEKSSRKIIQDESNVKKSKVVEEKEEMEDTLKLLDESLSLNKEENSFINKPKAEKKKSLKINGEKSSRKIIQDESNVKKSKVVGENEEMELEELEDTLKLDASNDSQSRELEETLKLPEIPEPVNYELVEVGDLKHQSYNEESDDGTDSSFGKLVIDESPDATIALLDTSNLNEIDFEKDSIVNEKDPLYVDNNDYPLAICVLEDENHSDVAHSEQQQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HB74</accession>
    <name>A0A8J2HB74_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Transposable element P transposase-like GTP-binding insertion domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS5709</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5090654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HB74"/>
    <dbReference type="OrthoDB" id="6485269at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048366">
        <property type="entry name" value="TNP-like_GBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47577:SF2">
        <property type="entry name" value="THAP DOMAIN CONTAINING 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47577">
        <property type="entry name" value="THAP DOMAIN-CONTAINING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21788">
        <property type="entry name" value="TNP-like_GBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transposable element P transposase-like GTP-binding insertion" evidence="2">
        <location>
            <begin position="4"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="114"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF21788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5090654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="471" mass="54049" checksum="E6E371C007B01904" modified="2022-05-25" version="1" fragment="single">MAYKLTPAHLDPKLYQKMSVPLAYQLYSREVRYAMTVLRENGNEKFEGSEPTEKFTKIIDDEDWEKMYTHTKTPNASTPKNSTPKNTVSKKITPRQSISKNSTLNQVIPQNTISKKSTSKSTSKKNSFPISASTISGFNVTLRAVLQILSELHHNYGYNYLITSRLTQDNLEIIFNMRYSCGANDYPTPRQFGQVFRLYCCNAMIKPPKGSNVTRVELLQTLMKTEDSLKMSRQPRMEWLEKIDKMLERTVPIGDIWNDNSSNDADGSSVSSIDLNASEPLTTEPTSRIQTTLESLEHHDYDVVSTSREVQAYMAGYIVRKMKLKCKCSSCFYTLQSSNDEPNCRDRFIDLMEKYGGLSRASDNLFQLTMQLEAAFLDVVGRVGLSRGIIYKILDRIESMLPQLSFVGCGIHQLEITKDIIDFYITMRLYFLGKTFNKRNQLKREKMKTLKKNFEISDLKNLIEIILRNPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HC13</accession>
    <name>A0A8J2HC13_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mediator of RNA polymerase II transcription subunit 26</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Mediator complex subunit 26</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HICCMSTLAB_LOCUS4589</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Mediator complex subunit 26 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5087720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HC13"/>
    <dbReference type="OrthoDB" id="550309at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070847">
        <property type="term" value="C:core mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010628">
        <property type="term" value="P:positive regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00183">
        <property type="entry name" value="TFIIS_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.10">
        <property type="entry name" value="Conserved domain common to transcription factors TFIIS, elongin A, CRSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042376">
        <property type="entry name" value="MED26"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003617">
        <property type="entry name" value="TFIIS/CRSP70_N_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035441">
        <property type="entry name" value="TFIIS/LEDGF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017923">
        <property type="entry name" value="TFIIS_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15201">
        <property type="entry name" value="CRSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15201:SF1">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08711">
        <property type="entry name" value="Med26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00509">
        <property type="entry name" value="TFS2N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47676">
        <property type="entry name" value="Conserved domain common to transcription factors TFIIS, elongin A, CRSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51319">
        <property type="entry name" value="TFIIS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0010">Activator</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="TFIIS N-terminal" evidence="11">
        <location>
            <begin position="7"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="192"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="263"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="392"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="192"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="227"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="264"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="315"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="394"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="404"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAG5087720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="589" mass="64741" checksum="ABE51E315A943990" modified="2022-05-25" version="1">MQRNCTELTERLLKSLDKEYNVVDMGAVVDVITALEKTTITKEVLEITRLGKYINELRRKTTNDALAKRAKDLVRRWRDMVLPSSNQQQHGSSNTAIAPPNAIIDNTSSHQTLNGTKPASPLITAARTIKPRSPVPGSAASRIKPQSPLMRDAITSKIISPALSLNSDSCSPNSTPLKLPIVTTNYKLNTAGSPKLSGTSNQNHSIEAVPRTHSSNKRLRKEDHFQQQHVNSPQQYDVNSTSRDELTSISILAAKKQRINGDLNVNTNSQVPNSPSSSSSTRNELNVNPVLDPSLSSNTYSPAVKVEPVPVPVGPKKRGRKKGSKSLKSQSLSEDRVKEKLASISRNPKLKTTHEILADIQVRNVTGALGATTAGQLKREPPTTEEVLRSSEINNRNLASNNNTRTKSLSGNRIESRSSAGNNTVSGVAGSGTDHAVVDAADVTKTERASEPAAEAPSIEATVKEILATLPPLDLDAIRWSDDEYSTHDNDHDEDHKLRQIDDSAVDRLHNECIESLNGNFQAKLSTNSVEKEVVDDVDEFVNKKMIGVYKRRVVDDDTDREFREWHEMLARPSYDGQILHILPYVIID</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HC69</accession>
    <name>A0A8J2HC69_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Similar to Gp5: Platelet glycoprotein V (Mus musculus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HICCMSTLAB_LOCUS4623</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5087848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HC69"/>
    <dbReference type="OrthoDB" id="2013775at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050541">
        <property type="entry name" value="LRR_TM_domain-containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24369">
        <property type="entry name" value="ANTIGEN BSP, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24369:SF210">
        <property type="entry name" value="CHAOPTIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="495"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG5087848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="495" mass="57296" checksum="9A46FC1960D8681A" modified="2022-05-25" version="1" fragment="single">MSSPRCFNFSLESQLKLFIIFCIVFVGVVNSNSLCKDKKSCDEYESEGKDEERKLNIEDVESRVSRLERRLRAMEQPVWQIRGWPEDWEVCVEGPCKCRPETKSISCWRYGLFDVPAGQLVPQDIIKLDLGSNQLTALHRDTDLSNNMIEHLPLNSFYSLYSITHLRFSKNLLRDLHQNLFLRMRYLEIVDLSSNKLQTLPEGLFVANTALLLLDISSNKISELPTDIFFNLKELEDLLLSKNQLSHLDKNIFKDLINLKCLKLEENHLRELQIGLFDSLGNLIELILRDNQIKVIPADLFINLEALTTLDLSNNLISQVIISFFFNQLVFRNSNWILNSQLNKEAFTGLKALKELRLGKNHIKVLPKGIFLQTPALQQLVLYGNALEKLSDGDFQGLGNLTSLFLHSNRIRRLQSDVLKDTPFLKKLQLESNQLSYVPGRFLDSVPMIQQLRLSRNPWHCDCEVAYLAMWLRKMYFARNNHNINSNNHNTNDNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HCM0</accession>
    <name>A0A8J2HCM0_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS6893</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5093521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HCM0"/>
    <dbReference type="OrthoDB" id="7685821at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5093521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="260" mass="30208" checksum="014217CB17F195A4" modified="2022-05-25" version="1">MPSKCAEDCPKSKKRREAYEKTLREEERNPTFEVSEDDVVVRKTNKNLQSNYDEDDISDGTEYLSFSRPKSSARPESSRPKRSKERSVKSKHEKKYSEHREKFEEDVYASKTSTRRRQNLKKKRRFSSRLNENCVNEECSGIPKRIVETESEESLSSDISCPSRCELDLTLLPSPSSPCDSSCPKQALLDQERERHQEEVDKYLLHGGLRYFDDLCHCSLKCLLTQICGDKFIQKTASSTAFFLLGIKLCFELEAWYIPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HCS4</accession>
    <name>A0A8J2HCS4_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Tafazzin family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HICCMSTLAB_LOCUS5117</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the taffazin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5089132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HCS4"/>
    <dbReference type="OrthoDB" id="193467at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047184">
        <property type="term" value="F:1-acylglycerophosphocholine O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035965">
        <property type="term" value="P:cardiolipin acyl-chain remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007007">
        <property type="term" value="P:inner mitochondrial membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000872">
        <property type="entry name" value="Tafazzin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12497:SF0">
        <property type="entry name" value="TAFAZZIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12497">
        <property type="entry name" value="TAZ PROTEIN TAFAZZIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAG5089132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="72" mass="8342" checksum="0BC514FF303CDD5D" modified="2022-05-25" version="1">MDQVLPNEPPYIIKLFKKVTIKYGEPIDFSKLLAELRASNADEVQARKAITDYIDAELLRLKKETEELHVKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HD26</accession>
    <name>A0A8J2HD26_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS5629</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5090436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HD26"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5090436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="150" mass="16695" checksum="7D0E65660CE32060" modified="2022-05-25" version="1">MLTSSTVNLQSMSNNVSVISARNTTISQIITPTRQRTQRPISYANVATSFLKKDQARIMILNAIEASTGVEDRESCDDVLLTLLTESSEYESDISNAQLEGNFVISKTAGIDVAIAFSELGMPLDWFVLKDTFNSDHFPIFIKLYTNNNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HDA6</accession>
    <name>A0A8J2HDA6_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Similar to mthl1: Probable G-protein coupled receptor Mth-like 1 (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HICCMSTLAB_LOCUS5766</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G-protein coupled receptor 2 family. Mth subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5090843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HDA6"/>
    <dbReference type="OrthoDB" id="8191206at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007166">
        <property type="term" value="P:cell surface receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15039">
        <property type="entry name" value="7tmB3_Methuselah-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017981">
        <property type="entry name" value="GPCR_2-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000832">
        <property type="entry name" value="GPCR_2_secretin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052808">
        <property type="entry name" value="GPCR_Mth-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036272">
        <property type="entry name" value="Methuselah_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46953">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR MTH-LIKE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46953:SF1">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR MTH-LIKE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00002">
        <property type="entry name" value="7tm_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63877">
        <property type="entry name" value="Methuselah ectodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50261">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 13" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035300031" evidence="11">
        <location>
            <begin position="23"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="271"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="339"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="384"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="432"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="476"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="506"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 2" evidence="12">
        <location>
            <begin position="270"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="543"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="548"/>
            <end position="577"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAG5090843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="584" mass="64902" checksum="794C70EA23BE4E6E" modified="2022-05-25" version="1">MAIALLTFLWIFIFNLFYITSASSILMLKCCKNGEELAISNNDPKSEFACVKSNTTWIPTIYSPLQKNFLSVIPNEWIIHEAIKPTCTENRTLTPILCSNISPCIIFDKGHAILDAAGSNTHISPSEYCADSKALLVCTVRKVEANRATSTIRPRVSRCCGEHAAFYEQRHSCVNQKDVENAPPLLPNTSVSIDVVTGFPSCTRSNNYTIVGNTDVSVLQSDGSLIVDGISLLSSQYCVERIKELDGKSKVFVCPEYAPQRPVNQDPDIRFMMYSISFIISSIFLGATLATGWLLPTSHHVLHWKCQTHHVLSLMLGDILMAIIQLAGDSLQGGTCKLLAILAHFFFLAAFFWLNTMCFNIWWTFRDLRPASLEKSQEILRLRVYACYAWGGPFLVAGLAALLDHLPAQPHNPFLRPRFGEKMCWFYGDTEILAYFFGPIGVLLIINVIFFIATARELTCGLWKGEFVKSTTERAALGRVCLKLVIVMGVTWVADIISWAVGGPNYLWYFTDLLNALQGLFIFIVVGWQPQVRAGLKKLFNRDPRTSAGRQGNGLSTTSHGMPSMGDSMTQNPSTKSAALETIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HDJ2</accession>
    <name>A0A8J2HDJ2_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ras-related protein Rab</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HICCMSTLAB_LOCUS7917</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="6">The small GTPases Rab are key regulators in vesicle trafficking.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Membrane</location>
            <topology evidence="6">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5095856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HDJ2"/>
    <dbReference type="OrthoDB" id="245989at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045335">
        <property type="term" value="C:phagocytic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008333">
        <property type="term" value="P:endosome to lysosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090385">
        <property type="term" value="P:phagosome-lysosome fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04107">
        <property type="entry name" value="Rab32_Rab38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002133">
        <property type="entry name" value="Ras family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030697">
        <property type="entry name" value="Rab29/Rab38/Rab32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47981">
        <property type="entry name" value="RAB FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47981:SF39">
        <property type="entry name" value="RAS-RELATED PROTEIN RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4 6" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 6" id="KW-0636">Prenylation</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU367128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAG5095856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="219" mass="25099" checksum="598BA17B960DC8E5" modified="2022-05-25" version="1">MNNRKPRRDSDVILSNYNQKELLFKFLIIGDYGVGKTAIVRRYTEGKFSSNYKITIGADFAIKSLDWDPHTKINLQLWDIAGHERFGYMTRVYYKYAVAAALVFDISRVATFQSVKKWLTDLREKVTLPDGSSIPIVLLANKCDIQHVAIPTDQIIKFCKENKISKWYVTSAKDNKNIDEAVHYLVENVLKAKIEDEIKDSIKLRTAPITTEKSGCCKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HEQ8</accession>
    <name>A0A8J2HEQ8_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS8313</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5096645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HEQ8"/>
    <dbReference type="OrthoDB" id="7700372at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2590">
        <property type="entry name" value="BEN domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5096645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="105" mass="11282" checksum="87F800F33E9124E0" modified="2022-05-25" version="1">MYVLIERQSAGTTSDPAAHIPTQRLLTISPVEIGHPGSNVFVNQQQWDTATAQNSYTTMGISLVRALFEEDVLLASNLRGSSSRSDTNAARRPGLNSVILAVIEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HF06</accession>
    <name>A0A8J2HF06_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Integrator complex subunit 12</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HICCMSTLAB_LOCUS7204</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Integrator subunit 12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5093878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HF06"/>
    <dbReference type="OrthoDB" id="5846437at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160232">
        <property type="term" value="C:INTAC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032039">
        <property type="term" value="C:integrator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160240">
        <property type="term" value="P:RNA polymerase II transcription initiation surveillance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034472">
        <property type="term" value="P:snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15501">
        <property type="entry name" value="PHD_Int12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000101">
        <property type="entry name" value="Integrator complex subunit 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039054">
        <property type="entry name" value="Int12_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051776">
        <property type="entry name" value="Integrator_subunit_12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13415:SF2">
        <property type="entry name" value="INTEGRATOR COMPLEX SUBUNIT 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13415">
        <property type="entry name" value="NUCLEAR FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="10">
        <location>
            <begin position="117"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="63"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="177"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="63"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="85"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="177"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="205"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="221"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="240"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="250"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAG5093878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="262" mass="29268" checksum="35F450D772D284DC" modified="2022-05-25" version="1">MTQLELDPQFVQGLRLLHSSNKDSMDQLRTLLDEAIKQKHGFSKMLCNVLHKKYTIEEPVLSDHSSCSSKKSKSSSSSKHSAKFSKSDSVEEIPARDTPPDISEIEEDNLAEILEDDLTCVVCKGMDVGARNRLVECADCHSLYHQECHSPVIQDSQIDVPKHIWYCSQCIKAHQPIKEKGSPKPDSKKDKKSSSQKHSEKYKSSSESSSKIIPNINIIGGDKRFKEVAKKSKDKRSSSKHSSPSSSSRSSDKTYKSKSNAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HFB2</accession>
    <name>A0A8J2HFB2_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Large ribosomal subunit protein mL46</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">39S ribosomal protein L46, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HICCMSTLAB_LOCUS7431</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrion-specific ribosomal protein mL46 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5094882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HFB2"/>
    <dbReference type="OrthoDB" id="194611at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04661">
        <property type="entry name" value="NUDIX_MRP_L46"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040008">
        <property type="entry name" value="Ribosomal_mL46"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021757">
        <property type="entry name" value="Ribosomal_mL46_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033650">
        <property type="entry name" value="Ribosomal_mL46_NUDIX"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13124">
        <property type="entry name" value="39S RIBOSOMAL PROTEIN L46, MITOCHONDRIAL PRECURSOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13124:SF12">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML46"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11788">
        <property type="entry name" value="MRP-L46"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Large ribosomal subunit protein mL46 N-terminal" evidence="10">
        <location>
            <begin position="31"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="Nudix hydrolase" evidence="9">
        <location>
            <begin position="145"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00035534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF11788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAG5094882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="301" mass="35306" checksum="7A6840DE53776913" modified="2022-05-25" version="1">MLKQSFKFYTCINTLSNQLKCQMSTASREKWDLLSAICVERHPIITAPKTEIEENFQGLLDEIELENSLKCDHELNVENEKRKDEKIKKGMIDLDADVITSMRAQDIEDQGDAELKEFKFASRITEADLKNITSSLERKLDKTLFLCVQQKIDNDNLWLPPQGLREQGENMRQAAERILRKTCGENLSVRIYGNAPMGFYKYVYPKTVRENGTRGAKIFYYLARYVNGNLPSNLKYQWLDRDELKEALPKPVYKSRELTLIRPLELLALAYCLQSLKRGKIFWLWYCLDSRRQHHRKNQLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HFE2</accession>
    <name>A0A8J2HFE2_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS6586</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5093106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HFE2"/>
    <dbReference type="OrthoDB" id="7713403at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5093106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="97" mass="11222" checksum="293B79FDF935C949" modified="2022-05-25" version="1">MDYPEEFEDKPGDLFERPRKRPQQTLEQMLATLTPLDQVRSQPFLPHQKRRRFTAYDPELRSYKAVQTRNQSSPTIVSTGTTAHDMLAKLQGSSSQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HFT0</accession>
    <name>A0A8J2HFT0_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 13">Tyrosine aminotransferase</fullName>
            <shortName evidence="13">TAT</shortName>
            <ecNumber evidence="5 13">2.6.1.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">HICCMSTLAB_LOCUS8613</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Transaminase involved in tyrosine breakdown. Converts tyrosine to p-hydroxyphenylpyruvate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 13">
            <text>L-tyrosine + 2-oxoglutarate = 3-(4-hydroxyphenyl)pyruvate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:15093"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:36242"/>
            <dbReference type="ChEBI" id="CHEBI:58315"/>
            <dbReference type="EC" id="2.6.1.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 13 14">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 13">Amino-acid degradation; L-phenylalanine degradation; acetoacetate and fumarate from L-phenylalanine: step 2/6.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 13">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.5" evidence="5 13"/>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5097249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HFT0"/>
    <dbReference type="OrthoDB" id="7042322at2759"/>
    <dbReference type="UniPathway" id="UPA00139">
        <property type="reaction ID" value="UER00338"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004838">
        <property type="term" value="F:L-tyrosine-2-oxoglutarate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006559">
        <property type="term" value="P:L-phenylalanine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006572">
        <property type="term" value="P:L-tyrosine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000048">
        <property type="entry name" value="tyrosine aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004838">
        <property type="entry name" value="NHTrfase_class1_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005958">
        <property type="entry name" value="TyrNic_aminoTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005957">
        <property type="entry name" value="Tyrosine_aminoTrfase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01264">
        <property type="entry name" value="tyr_amTase_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01265">
        <property type="entry name" value="tyr_nico_aTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45744">
        <property type="entry name" value="TYROSINE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45744:SF2">
        <property type="entry name" value="TYROSINE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000517">
        <property type="entry name" value="Tyr_transaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00105">
        <property type="entry name" value="AA_TRANSFER_CLASS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 16" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="11" id="KW-0585">Phenylalanine catabolism</keyword>
    <keyword evidence="10 13" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0828">Tyrosine catabolism</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="15">
        <location>
            <begin position="43"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="14">
        <location>
            <position position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00015959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRNR" id="PIRNR000517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR000517-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CAG5097249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="431" mass="48219" checksum="63D3652FA8E81FAA" modified="2022-05-25" version="1">MLNSLGTPRDRWDVCASDIARRTHNPIRAIVENIVVEPNPNKKLIALSIGDPTTFGNLKPPREVIEALQQSVASFEFNGYAPSTGHQIAREAVAEYCSTENLKVEAKDVILCSGCSCALDLCITVLAKEGQNILIPRPGFSLYRTLAVGLGVGVRAYNLLPDLGWEIDLDHLASLVDERTAAIIVNNPSNPCGSVYSRHHLLDIIDVAAKYHVPIIADEIYEHMVFPGRTFYPMASLSTEVPILSCSGLAKRFLVPGWRMGWVIIHDRQNIFNNEIRNGLQSLSQRIIGSSTIIQGALPGILKNTPQRFFDDVTKLLYNHSITTFNLIKEIPGLKPIMPDGAMYMMVHIDLESFPEFNTEVDFVERLLMEESVFCLPGGCFDLPSYIRLVITVPVEMQEEACKRIHDFCYRHHCKTQNLIRNSIEGVEIPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HG47</accession>
    <name>A0A8J2HG47_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Hepatocyte growth factor-regulated tyrosine kinase substrate</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HICCMSTLAB_LOCUS7237</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5093911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HG47"/>
    <dbReference type="OrthoDB" id="957735at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032456">
        <property type="term" value="P:endocytic recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031623">
        <property type="term" value="P:receptor internalization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15720">
        <property type="entry name" value="FYVE_Hrs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21387">
        <property type="entry name" value="GAT_Hrs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22249">
        <property type="entry name" value="UDM1_RNF168_RNF169-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03569">
        <property type="entry name" value="VHS_Hrs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000028">
        <property type="entry name" value="Putative hepatocyte growth factor-regulated tyrosine kinase substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017073">
        <property type="entry name" value="HGS/VPS27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024641">
        <property type="entry name" value="HRS_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003903">
        <property type="entry name" value="UIM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002014">
        <property type="entry name" value="VHS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000306">
        <property type="entry name" value="Znf_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46275">
        <property type="entry name" value="HEPATOCYTE GROWTH FACTOR-REGULATED TYROSINE KINASE SUBSTRATE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46275:SF1">
        <property type="entry name" value="HEPATOCYTE GROWTH FACTOR-REGULATED TYROSINE KINASE SUBSTRATE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01363">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12210">
        <property type="entry name" value="Hrs_helical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00790">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036956">
        <property type="entry name" value="Hrs_Vps27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00064">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00288">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50330">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50179">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="VHS" evidence="12">
        <location>
            <begin position="15"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="FYVE-type" evidence="11">
        <location>
            <begin position="160"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="239"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="314"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="573"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="598"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="417"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="263"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="273"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="314"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="579"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="630"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="648"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="662"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="679"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="693"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="715"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00015450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAG5093911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="715" mass="79657" checksum="D914044BA9C5468D" modified="2022-05-25" version="1" fragment="single">MFQRSPNFYQLLDKATSHLHLDPDWPTILQICDLIRQGDIQPKPALAAIKKKITNSNPHVSLFGLLVLESCVKNCGSLIHDEIGTKQYMEQLKELVKTTIHDDVKSKILGLIQAWAFAFRNSPKYTAVKDTMNIMKAEGYVFPELKESDAMFSADTAPEWADGEVCHRCRVAFGMVQRKHHCRACGQVFCGQCSSKTSTLPKFGIEKEVRVCDACYIVINKPSSASTKETDLPVEYLSSSLAQQQQVPPRKSEEELREEEELQLALALSQSEAEQKEKDKKRGPSPSKIHEEETDPELAKYLNRKYWEQRQIVNEEQTGGSRADVTSPSAPNIGSPMPQRIVVAKQQNGDIDVHLDEFVSNLRSQVEIFVNRMKSNSSRGRSIVNDSFFQTLFMNITAMHSRLLKYIQEHDDTRVYYEGLQDKLAQVKDARAALDDLREEHRNKLRREAEEAERQKQMQMAMKLDIMRKKKQEYLNYQRQLALQKIQERERELQMRQEQQKQQYMMGGYQTVPNYMGPSQGSPIRHVQYQVPGTNYNPMSPTSQGVYSYGPTSMGPYPMPNYSMAQMGSLPPHLMANMPATQDQPQSGPNESMIQQRENMAPASQPGMSGDISQAVPPAGASQIGPSQTGMHGPPGHMGIPQAPGSAQIPQGIPQQMPQHVTVGSNIPPSQAPGSIQMPGGGGGGGGGTNGASPQISQTQIPSQPIQYSASVVST</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HGQ5</accession>
    <name>A0A8J2HGQ5_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">small monomeric GTPase</fullName>
            <ecNumber evidence="2">3.6.5.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HICCMSTLAB_LOCUS9903</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Endomembrane system</location>
            <topology evidence="10">Lipid-anchor</topology>
            <orientation evidence="10">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.2" evidence="2"/>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5100830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HGQ5"/>
    <dbReference type="OrthoDB" id="5976022at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003925">
        <property type="term" value="F:G protein activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000343">
        <property type="entry name" value="Ras family gtpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020849">
        <property type="entry name" value="Small_GTPase_Ras-type"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24070">
        <property type="entry name" value="RAS, DI-RAS, AND RHEB FAMILY MEMBERS OF SMALL GTPASE SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0488">Methylation</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="12"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="226"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="21"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="235"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00046278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAG5100830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="267" mass="30857" checksum="15FFB38950447DEC" modified="2022-05-25" version="1">MNICGDLNKLNHNDDYKKNESTSNNQQHQNGGADDKRQDLPLSTDVIQLNTRCVQPRIYKIVVLGDGGVGKSAVTLQFVTHSFLEYHDPTIEDSYRQQAVIDGEAALLDILDTAGQIEFTAMRDQYMRCGEGFMICYSVTDRHSFQEVPEYRKLISRVRVNEEYIPLVLVGNKFDLQSQRKVTTEEGKVLANQLGCPFFETSAALRQFIDDAFYSLVRQIRLKERNQDNDSTTRAQKKHSSSHSRWRRLRSIFAFIFRRKNRNIQKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HGS2</accession>
    <name>A0A8J2HGS2_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS9715</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5100642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HGS2"/>
    <dbReference type="OrthoDB" id="8184047at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579">
        <property type="entry name" value="F5/8 TYPE C DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579:SF1">
        <property type="entry name" value="F5_8 TYPE C DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="54"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="99"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="142"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5100642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="751" mass="86101" checksum="561074B8864C0C33" modified="2022-05-25" version="1">MRKQLREQTQGARYKYMKSVEKSDENKHEKLSESEQTKTAEEFLQITNPELDNDTSNINNSSDHPNPSNSRESSSSENSTFDDDTSNINNSSDHLDPLNSSESSSSENSTFDDSSNEITPNNSSNNADSSISAESEDSRILDNIGDNNPNISNNDGAENINNADRLLIPLYRGSVMNVEQSNLMILSLLLKHNMTQSCISDVMEVVKFHCPSEDLQKNNLHTLNKYVSKAEPLKHYYCVNCLNNLMTEDEKCSCGHEEVAYFLQLSIFDQLQELFCRPGFFEQLQHRFHRQKTSNTSVEDIYDGTLYQKYWRNGFFASPCNISLTWYIDGVSPFKSSKYSLTPFYIRINELPYHKRILKENTILAGLLYEGKQLYIHDLNALRTVKAVLLTGTADLPAKAAVLNMMLFNGEYGCVDCENPGETLKLNTGGHTHIYKYQPNAPLRSLTSVLHYADESVALKKVINGVKGPCALSKVMPNFIVGNAIDLMHCIYEGNAKKLMHLWFDVEYSSSPFSFRQVFDVIKDKFKNIQVPRFVHRFNTIDNFATWKASEFKNWFFYYSVPILSDIMTLDDKVKSLGPLWSHSCFSLENLNGLMIKICMVQPMQIHKLLIHIGKIYCYILEYKDYLMVQCVILLKGKKTKIFDKFSTVGTYSKFDLDKDNVVTRSLNNGNIRGVYGLEYFRLLLNGTFFISKNYKETLKNNSSYVAFKYLNEKRFGLLHSFIKIIDKICDCQKSSNKKFIAELVNHYENE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HHT4</accession>
    <name>A0A8J2HHT4_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">THAP-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">HICCMSTLAB_LOCUS5689</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the THAP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5090593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HHT4"/>
    <dbReference type="OrthoDB" id="7555211at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.210.20">
        <property type="entry name" value="THAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026516">
        <property type="entry name" value="THAP1/10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006612">
        <property type="entry name" value="THAP_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038441">
        <property type="entry name" value="THAP_Znf_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46600">
        <property type="entry name" value="THAP DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46600:SF1">
        <property type="entry name" value="THAP DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05485">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00692">
        <property type="entry name" value="DM3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00980">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50950">
        <property type="entry name" value="ZF_THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8 12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="THAP-type" evidence="13">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CAG5090593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="247" mass="28373" checksum="0AA7D24BA150C9C2" modified="2022-05-25" version="1">MVNSCLCDRKASRADNISLHRFPKNLDVRIKWLNACGLTINDDVRRTSICSRHFKAEDICQSNFFGTVKSSIKRNAVPTLHLINPIIIDTSNKSQPNTPLSELFNENGVTNQSSYFPDNNVLDIVEKSPENFVELDNFEIQTSNKSNINSDGSCEQYDLNQSMKNTILNFSSEDENTVPGENNSPSQCRKRKFFEPRYISEISPTDFATPKRAKRTLDLIKKSDRRKTEKIKQLQRQTRLTFWTILS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HIC4</accession>
    <name>A0A8J2HIC4_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS8204</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5096427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HIC4"/>
    <dbReference type="OrthoDB" id="10559055at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="73"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="191"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="191"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="265"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5096427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="274" mass="32242" checksum="EA2A037686A1480D" modified="2022-05-25" version="1">MSKKTGTKTWLWSLRKDAVISELEKFRVEIEPKATLPELRFLLKAELNKLRAANAGRAGRYDQLLIDLDQSEAELDNLENLPEETEEDDPENDDEYLSDEDPEGDNASPERERIEREERERLAREAREKAEKEQAEKEQERVAREAAEQADWELRERLRQEIRARLLREKEEQRAFELQLDAREARMRYEAEQRKKAEREARMNTHGNNRDRVSSLENERRGGGDGNRRSERMVDFVSPTRVGPSFSGTPRHDHQHLSVLGDDSVELRRRDLVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HID4</accession>
    <name>A0A8J2HID4_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similar to bath-42: BTB and MATH domain-containing protein 42 (Caenorhabditis elegans)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS10786</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5101980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HID4"/>
    <dbReference type="OrthoDB" id="10249567at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd14733">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24413">
        <property type="entry name" value="SPECKLE-TYPE POZ PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="180"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5101980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="362" mass="41952" checksum="C501A6D6DE35DC6C" modified="2022-05-25" version="1">MIKSLNFIFKKIIMNFAYSKTNDIKCRWEIPSKNNYRSVRNYFMKPLEYCLITVSMDYEASCSDIIIEISREYKIVPGTVAVEVYSNNKIKYSEIIDHWFENGLNIFVPNNCSKDDNESSSDSFESLEDSHETNYLRVLCEIKWLGCTSDVCLSCPLVNNYLNNYTNDDFKSFYLDRMLSDVVLVVDDEEIVAHKVVLSAHSPVFLAMFQSNMKEARENCITIENISVDVMKEVLKFMYTGTTEAEENYELALKILDVAERYQILKLKNFCGAIVFRYLSLNNVISIAIEAEKYNADILRQMAIQLIVKNIDTIVFLNDYKQLGSTHPVPIYNIISSDSSKYDVRFYPPGSNGRHQRYCNLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HIP6</accession>
    <name>A0A8J2HIP6_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS9768</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5100695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HIP6"/>
    <dbReference type="OrthoDB" id="7697575at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46601:SF2">
        <property type="entry name" value="UBIQUITIN-LIKE PROTEASE FAMILY PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46601">
        <property type="entry name" value="ULP_PROTEASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5100695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="262" mass="31541" checksum="AD2800C2F2CBDC66" modified="2022-05-25" version="1" fragment="single">MSRSRKSTAAEAKLKKKEYDRKRREKLKNCPESLEKLREKERLKYLNKKEKGQVKSVSAMSSRERRQKQKLWRLNSSKYREKNQNVLKHDINDFLEKDENSRMCPGKRDFVRSEKLLKQKRLLTDNMRNLHKKFLNSVTYKISLSTFCKYRPFWVTWANLKERDTCKFVVHVNIELIISKLHENKVILHNNIPSLLSDITCDIYCTKCLFRECINCRDKALEYNLSQATKTITYRQWMYENLTYEKNGETKTVRKPLKKEIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HIX8</accession>
    <name>A0A8J2HIX8_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similar to AGAP005037: Coiled-coil domain-containing protein AGAP005037 (Anopheles gambiae)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS11196</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5102812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HIX8"/>
    <dbReference type="OrthoDB" id="6022652at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="233"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="105"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="127"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="179"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="233"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5102812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="374" mass="41408" checksum="30BB107DB4DA34CF" modified="2022-05-25" version="1">MAWPKAQPFTAASLSAEHKLESSDIIRGAPISTLSNFNQQRSENTLDALLNELQTYSRPSSQLSQTSNATQHIEYLPSPIIVSKHTPSTKLKKVINNDRKKSMDSLNTLTTKTQNTSSTLRRLHSYPSGSDTDTSPPTTNIDDSESINTFEKPPIPERNVEFLPLATLKRVPPPPPPRTSSKSPSISPTSPQLPPKNSASISYRNRHAKEITELSIRFPTHIVQEQVLNQTQASNVHTTSDSSSCESINSQDGSQNKKDRQDQLELRHKELLRKQKTLQEQYARLQQLQRNTAGSITTPTESPDLLKKTGSESNILAKMGLGLCTMNSGSLTSLTCKDYPEPQLSSKIESHHSLVISAVEEQASSNKIYETDIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HJ13</accession>
    <name>A0A8J2HJ13_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS9323</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5099978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HJ13"/>
    <dbReference type="OrthoDB" id="18740at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="58"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="125"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="146"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5099978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="216" mass="24266" checksum="05D877446055E2B3" modified="2022-05-25" version="1">MSEQTPPKGETLKPTGSPRTPRGGRLRDRVNFFENIWSQGRSASSEDLVERSDSPVQRRSSSRTSDSSFEESFERLVEEGELNGAKVVKFEKITVRRSVKEVISSRSGLSEASRTPSEEQALDSAYQSHGYQGSKSSSVGSFTKFPSEENLGRESPQDDDKGPSEWYAEYRNQSFQHVTSKREYVRSRSEFDAHIAEIKGLSTDFLEANAYYIVVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HJ19</accession>
    <name>A0A8J2HJ19_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS6487</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5092968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HJ19"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="31"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5092968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="407" mass="47810" checksum="C153CE8A17A4C7FD" modified="2022-05-25" version="1">MDRLKSLFFHRSLNCKNDPEKIKSISKEELAEKLKDHIKVSLEEIKNLNDNLQSAFEQTFVQNNENIYYNKRLNTVIDYLTIVRCLDQELRSLEKKSNDFVQKISNYKIKSLNVDNLIDLLDPDDENFDPLDITALFDDQLVPASETQLEGLTSQRINTDFPMRYFGAKDTFAINRRKYQKHECNYLLSSEKEEEEEDINCNTRIKRVPINNDSFTFKHKILIPKMYHNNPSSTCFSKQIDLVWKESYNDVQYSRSSKTICMEFVDDDEFIYITKLSLTLFKHKELTAINRIIFITSSTRIMSWFGRFLAWRFQVPSDIVNLYSLDNNGTVDDWKEWKLNGGVLFVDFDAFQRNQTELSLYNLINSHSPDLLIIDLNLPLDGDVPEDIKNIINDMFCSLKLILQTSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HJN8</accession>
    <name>A0A8J2HJN8_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS6885</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5093505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HJN8"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035184080" evidence="1">
        <location>
            <begin position="25"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5093505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="115" mass="11380" checksum="277E72FC6638F77A" modified="2022-05-25" version="1">MIGKMSLTFNCAILLACACQISMAGVIAPVVAAPLAAAPLPAAAPLVGYAHAVPHNIPPHASRVDISTRALAAPYVVAPAVSAPIISAPTAPVVAAHPGFFGAPFAAYRSAAIFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HKA0</accession>
    <name>A0A8J2HKA0_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Similar to Myrosinase 1 (Brevicoryne brassicae)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HICCMSTLAB_LOCUS7277</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the glycosyl hydrolase 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5093951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HKA0"/>
    <dbReference type="OrthoDB" id="65569at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000013">
        <property type="entry name" value="lactase-phlorizin hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033132">
        <property type="entry name" value="GH_1_N_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001360">
        <property type="entry name" value="Glyco_hydro_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10353">
        <property type="entry name" value="GLYCOSYL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10353:SF36">
        <property type="entry name" value="LP05116P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00232">
        <property type="entry name" value="Glyco_hydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00131">
        <property type="entry name" value="GLHYDRLASE1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00653">
        <property type="entry name" value="GLYCOSYL_HYDROL_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035279754" evidence="7">
        <location>
            <begin position="20"/>
            <end position="529"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG5093951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="529" mass="60195" checksum="13C8382377337EE7" modified="2022-05-25" version="1">MWVLGNVSLLLGLMDSLTSMLPDFADMDYYATSKSLVGIQRVNAAKEGRFPDDFLFGVSTSAYQTEGAWNVSGKGESIWDYATHNSPETVIDNSNGDIAANSYFMYKTDIDLAKQLGCNAFRISISWPRILPTGFPNSLNPKGIEHYNNVINEMLGRNITPVVTLFHWDLPKELQDLGGWTNPLIVDWFVDYARIVFKAFGDRVKYWSTVNEPTVYCVYGYGGKMVPFVNHTGITDYLCGHHMLLAHAKAHKMYNEEFRQEQKGKVGLSISVPWAVASNPEDPEEVAGADRWFEFWGSWFLNPLFGHFGDYPEKMKSRIAENSLKQGFPRSRLPEFTAEEISMLRNSTDFLGLNYYHASPVQKYQNYNVTSTVSFFGDIEMLEVPANQNGAAFSDRSTSWALVSTIQKINKDFEVPMIMITENGYWDRGQLADIGRAKYHHEHLSELPGLIAQGINIRGYFAWSLIDNFEWSVGYTQKFGLFSVDYTVPERTRIPKISTKVISDFYKTKKIPLFLWSLNEVEFDINVGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HKY1</accession>
    <name>A0A8J2HKY1_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS9785</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5100712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HKY1"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035263571" evidence="2">
        <location>
            <begin position="23"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5100712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="143" mass="16033" checksum="575093F239B8D6A7" modified="2022-05-25" version="1" fragment="single">MVSAKIITILVFITANAIYSGAFPYDLPDSGFDTMNDWSPPELPDSGFDNMNDWSPPELPDSGFQDMNDWSPGIPDSGFQNMNDWSPDSPAFNQDNYSPNYPPSIYPQPIYPQPINPQPIYPQPIYPPNSNQGYQNSYNPAFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HLY0</accession>
    <name>A0A8J2HLY0_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Olfactory receptor 210</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HICCMSTLAB_LOCUS11017</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5102442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HLY0"/>
    <dbReference type="OrthoDB" id="6597368at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005549">
        <property type="term" value="F:odorant binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004984">
        <property type="term" value="F:olfactory receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004117">
        <property type="entry name" value="7tm6_olfct_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21137">
        <property type="entry name" value="ODORANT RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21137:SF35">
        <property type="entry name" value="ODORANT RECEPTOR 19A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02949">
        <property type="entry name" value="7tm_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0552">Olfaction</keyword>
    <keyword evidence="8 12" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="9" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="34"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="126"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="167"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="267"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="301"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="205"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAG5102442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="375" mass="43043" checksum="46A534C89643E082" modified="2022-05-25" version="1" fragment="single">MTTAVLSRSIFILTLVGLWQPIDWRGWKSLLYNLYTYFVAFANFAFILTELVDIVTNSSSVNDLTNGLTRTVGQLGAFGKVIGMMLNRKMILQGIKLLELKPFKLEDQNENNVLKKYISISNYLTYFYTVAFTFGGSGAVSAQLSIMEYPDVLPYRAWFPYNYSQPIYFQTTAAFQIYTFFLGAYVHASFDALYFGMMFCVIIQINVLEHRLEKVMSNMKKLLTNNIDLNANEVNHACVMLIEEWVNHHNDVLRYSQSMYELFSGPIFLQYCLSSTQICITVYIMSNVPLFSGIFVSEMPFLMGTTTQIFTLCMIAHLVTLKFEDLNYSVYSTDWFNLNTKLQKSICVIISQTLKPVVFTSGYFVTLSLESFKHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HM34</accession>
    <name>A0A8J2HM34_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ceramide transfer protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Collagen type IV alpha-3-binding protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">HICCMSTLAB_LOCUS10174</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>N-hexadecanoylsphing-4-enine(in) = N-hexadecanoylsphing-4-enine(out)</text>
            <dbReference type="Rhea" id="RHEA:45720"/>
            <dbReference type="ChEBI" id="CHEBI:72959"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5101101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HM34"/>
    <dbReference type="OrthoDB" id="2344588at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035621">
        <property type="term" value="P:ER to Golgi ceramide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08872">
        <property type="entry name" value="START_STARD11-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.530.20:FF:000003">
        <property type="entry name" value="Collagen type IV alpha-3-binding protein-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041952">
        <property type="entry name" value="STARD11_START"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002913">
        <property type="entry name" value="START_lipid-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051213">
        <property type="entry name" value="START_lipid_transfer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19308:SF53">
        <property type="entry name" value="CERAMIDE TRANSFER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19308">
        <property type="entry name" value="PHOSPHATIDYLCHOLINE TRANSFER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01852">
        <property type="entry name" value="START"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00234">
        <property type="entry name" value="START"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50848">
        <property type="entry name" value="START"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="11" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="START" evidence="13">
        <location>
            <begin position="358"/>
            <end position="561"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00021440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00031527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CAG5101101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="567" mass="64105" checksum="B51CB465B8611CBD" modified="2022-05-25" version="1">MADVNPLVNEEEMMEIAGIDTGGGGCGDEIDEEESEGVIVPELQGTLSKWTNYIHGWQTRFIVLKDGTLSYYKSEQDSGFGCRGSISLYKADIKAESGYSSENSLKRHGSTVSLVSNTQSTASGGSLNKRGLRNLKEKLAELETFKDILSKQIDTLQKYFDNCAGNVSPSPVSSVSQEPRVNSHEFIKNDIGFDPALQSIDFKGEAITFKATSEGILSTLQHCVELMGQREDVWRRRWEKENERRKKMQELYKALKDQINIHRGDSIRPRVLIHGGPDYEEGPHSALCDEEFYDAVETGLDKIDEDNQMRDRLKRKSVSISVDSTVTPAVNHKLWPEIEKVTMQQLHYARLGVGGAGGWQLFAEDGDMRMYRREEEADGLVVDPLKACHVVKGVTAREVCQIFFSPEYRSGWETTLEDMTIAETISNDTLVFLQTHKRIWPASQRDALFWSHIRSVPDDQDPDASDLWIVCNHSTEHPQYPPNSNKCVRVYLTVCIVCQTFVDPPKDPNKISRDDITCKITYCSVVNPGGWAPASVLRAVYKREYPKFLKRFTSFCIEQCKDKPILF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HNA3</accession>
    <name>A0A8J2HNA3_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">14-3-3 protein epsilon</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HICCMSTLAB_LOCUS10822</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the 14-3-3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5102052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HNA3"/>
    <dbReference type="OrthoDB" id="10260625at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd10020">
        <property type="entry name" value="14-3-3_epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.190.20:FF:000002">
        <property type="entry name" value="14-3-3 protein epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.190.20">
        <property type="entry name" value="14-3-3 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000308">
        <property type="entry name" value="14-3-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023409">
        <property type="entry name" value="14-3-3_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036815">
        <property type="entry name" value="14-3-3_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023410">
        <property type="entry name" value="14-3-3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18860">
        <property type="entry name" value="14-3-3 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00244">
        <property type="entry name" value="14-3-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000868">
        <property type="entry name" value="14-3-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00305">
        <property type="entry name" value="1433ZETA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00101">
        <property type="entry name" value="14_3_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48445">
        <property type="entry name" value="14-3-3 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00796">
        <property type="entry name" value="1433_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00797">
        <property type="entry name" value="1433_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="14-3-3" evidence="6">
        <location>
            <begin position="4"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="235"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="253"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with phosphoserine on interacting protein" evidence="3">
        <location>
            <position position="57"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with phosphoserine on interacting protein" evidence="3">
        <location>
            <position position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00039427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000868-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAG5102052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="262" mass="29896" checksum="118556B332F9802A" modified="2022-05-25" version="1">MAEREDNVYKAKLAEQAERYDEMVEAMKKVASLDVELTVEERNLLSVAYKNVIGARRASWRIISSIEQKEENKGAEEKLEMIRQYRSQVEKELRDICADILDVLDKHLIPCASTGESKVFYYKMKGDYHRYLAEFAIGTDRKEAAEKSLIAYKEASEIAMTGLPPTHPIRLGLALNFSVFYYEILNSPDRACRLAKAAFDDAIAELDTLSEESYKDSTLIMQLLRDNLTLWTSDMQGDESDTEQPLLHVDNPVSDDNDNTHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HNN1</accession>
    <name>A0A8J2HNN1_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Similar to ZCCHC4: rRNA N6-adenosine-methyltransferase ZCCHC4 (Homo sapiens)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HICCMSTLAB_LOCUS12319</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the vasopressin/oxytocin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5106557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HNN1"/>
    <dbReference type="OrthoDB" id="431817at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005185">
        <property type="term" value="F:neurohypophyseal hormone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008988">
        <property type="term" value="F:rRNA (adenine-N6-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.9.10">
        <property type="entry name" value="Neurohypophysial hormone domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041370">
        <property type="entry name" value="Mlase_EEF1AKMT1/ZCCHC4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000981">
        <property type="entry name" value="Neurhyp_horm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036387">
        <property type="entry name" value="Neurhyp_horm_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022423">
        <property type="entry name" value="Neurohypophysial_hormone_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039846">
        <property type="entry name" value="ZCCHC4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017921">
        <property type="entry name" value="Znf_CTCHY"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13493:SF3">
        <property type="entry name" value="RRNA N6-ADENOSINE-METHYLTRANSFERASE ZCCHC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13493">
        <property type="entry name" value="ZINC FINGER CCHC DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00220">
        <property type="entry name" value="Hormone_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00184">
        <property type="entry name" value="Hormone_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10237">
        <property type="entry name" value="N6-adenineMlase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00831">
        <property type="entry name" value="NEUROPHYSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00003">
        <property type="entry name" value="NH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49606">
        <property type="entry name" value="Neurophysin II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50216">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00264">
        <property type="entry name" value="NEUROHYPOPHYS_HORM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51270">
        <property type="entry name" value="ZF_CTCHY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CTCHY-type" evidence="10">
        <location>
            <begin position="357"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="410"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="495"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="442"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="495"/>
            <end position="523"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAG5106557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="674" mass="77360" checksum="B738050C2C3ACF5B" modified="2022-05-25" version="1">MEVESNIECFWSDLKTHPKCPHGPTLLFAMRVKDDLKHFYACSACRDRKLCKFYLKKDGELTENEKKKWQNEIKTYSQMYNHQKSYIRFHELLSEQPERRAYCHTCEKLISVNEISKHPEHEVVKNISNDQMYNPTTLLKPRTDSKKEAQYLFSKKATSEIVDLLINLGAKHVLCIGAPRIHEHISQNHEDKLSSLLLDFDGRFHDFFGPLSFCWYNLFNHHFFNKESQSVFKDFITQNNGKDIYVVCDPPFGGRVEPMSQTIKTISDLHKKWNGLSQDDELKVMLFMPYFMKSIIQFKSNPAGVDGGLKELKMAEYKVDYDNHTLFGSGSNGRKFGSPVRIFTNIPLNLIKLLEDDGYKYCKRCDKWVGAENKHCKKCKACTSEDGRRYKHCNICNRCVKPTWKHCQKSKSSKKRKASDDNSMKNNKKQKLNGSDTIEVKKNKKKKDNKIKKHQEDEIVEEEKINAVEFTEKIKLEKTKKKKLKIKGVRGEITETSKENGHVKEKTTDKTTNGEKKGNDNSKVKKKKRSLTELESGSKIIFACLITNCPRGGKRGESPLLSMPSLIKECSSCGPGDQGQCFGPHICCGATIGCYIRSPETYKCRKESLHSHPCVSGFAMCRDNTARCAANGICCSQESCFLDSSCKIGDEYLSDRKIDQEFPRLIGETDQMIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HNN4</accession>
    <name>A0A8J2HNN4_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="21">Similar to nAChRalpha2: Acetylcholine receptor subunit alpha-like 2 (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">HICCMSTLAB_LOCUS11080</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="1">After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="17">Postsynaptic cell membrane</location>
            <topology evidence="17">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5102568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HNN4"/>
    <dbReference type="OrthoDB" id="5975154at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045211">
        <property type="term" value="C:postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022848">
        <property type="term" value="F:acetylcholine-gated monoatomic cation-selective channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007271">
        <property type="term" value="P:synaptic transmission, cholinergic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd19031">
        <property type="entry name" value="LGIC_ECD_nAChR_proto_alpha-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19064">
        <property type="entry name" value="LGIC_TM_nAChR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.170.10:FF:000013">
        <property type="entry name" value="Acetylcholine receptor subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.390:FF:000012">
        <property type="entry name" value="Acetylcholine receptor subunit alpha-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.390">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006202">
        <property type="entry name" value="Neur_chan_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036719">
        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038050">
        <property type="entry name" value="Neuro_actylchol_rec"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006029">
        <property type="entry name" value="Neurotrans-gated_channel_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018000">
        <property type="entry name" value="Neurotransmitter_ion_chnl_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002394">
        <property type="entry name" value="Nicotinic_acetylcholine_rcpt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00860">
        <property type="entry name" value="LIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18945">
        <property type="entry name" value="NEUROTRANSMITTER GATED ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02931">
        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02932">
        <property type="entry name" value="Neur_chan_memb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00254">
        <property type="entry name" value="NICOTINICR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00252">
        <property type="entry name" value="NRIONCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90112">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane pore"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00236">
        <property type="entry name" value="NEUROTR_ION_CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="16 18" id="KW-0407">Ion channel</keyword>
    <keyword evidence="9 18" id="KW-0406">Ion transport</keyword>
    <keyword evidence="15" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="10 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-0628">Postsynaptic cell membrane</keyword>
    <keyword evidence="12 21" id="KW-0675">Receptor</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 18" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0770">Synapse</keyword>
    <keyword evidence="5 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 18" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 18" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="18">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035337632" evidence="18">
        <location>
            <begin position="24"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="243"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="274"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="308"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel ligand-binding" evidence="19">
        <location>
            <begin position="28"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel transmembrane" evidence="20">
        <location>
            <begin position="249"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00034104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU000687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF02931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF02932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="CAG5102568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="496" mass="56159" checksum="E0F88D2ACBB3DFBF" modified="2022-05-25" version="1">MIIMSMIYGRLIIITLALGVCYCNPDAKRLYDDLLSNYNRLIRPVSNNTDIVVVKLGLRLSQLIDLNLKDQILTTNVWLDHEWQDHKFRWDPNEYGGMKELYVPSEHIWLPDIVLYNNADGEYGITTMTKAVLHYTGKVLWTPPAIFKSSCEIDVRYFPFDQQTCFMKFGSWTYDGLQIDLKHINQKSGNNNVEIGMDLREYYPSVEWDILGVPAERHEKFYPCCLEPFPDIFFNITLRRKTLFYTVNLIIPCVSISYLSVLAFYLPADSGEKIALCINILLSQTMFFLLISEIIPSTSLALPLLGKYLLFTMVLVGLSVVVTIIILNVHYRKPSTHKMAPWVRTVFIRKLPKLLLMRVPENLLNELAANKIYGRGKAAKKTKFEAAISAAMRSPSVMSSPESIRRRGCNGLHTTSGNRFIGLEAGMAGYNGLPTVMSGLDESMTSIAGTFAILCEAPSLYDDTKPIDMQLSAIAQQQFPPRNPTLLKGILPQRAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HNQ6</accession>
    <name>A0A8J2HNQ6_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Similar to Smyd4: SET and MYND domain-containing protein 4 (Mus musculus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HICCMSTLAB_LOCUS9838</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5100765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HNQ6"/>
    <dbReference type="OrthoDB" id="7770870at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042826">
        <property type="term" value="F:histone deacetylase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008170">
        <property type="term" value="F:N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008276">
        <property type="term" value="F:protein methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052097">
        <property type="entry name" value="SET-MYND_domain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46165">
        <property type="entry name" value="SET AND MYND DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46165:SF6">
        <property type="entry name" value="SET AND MYND DOMAIN-CONTAINING PROTEIN 4-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01753">
        <property type="entry name" value="zf-MYND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50865">
        <property type="entry name" value="ZF_MYND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SET" evidence="8">
        <location>
            <begin position="220"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="domain" description="MYND-type" evidence="9">
        <location>
            <begin position="265"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAG5100765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="639" mass="73228" checksum="A955B04A57C42561" modified="2022-05-25" version="1">MAKVKKSVVKDRRSSIVKISVDTSEEDFQNEEETMAYVLSSMVVTNNLKGKEREEKSGKGAFRALNRVNRIRSTASLQVQLELYSRAIAHAPLESYELVRAYTERSELLLNQGYYEDCLKDIERISKIGCCNEMKADFYTRKAKALWGLNPRMCPEIEKAITKAQCWLTEADEETRQNLETSLNLILKNYALKANFIQHDLGKLIPLTPKDNPRVVGASSSIELKFSENFGRHIVATKDIKVGEVIFVQKAYSLILSSECWYTYCWYCSKRTWSSVGCNNCVNVIYCDESCRDKAWVEYHDMECDVISYLLAMGQREWLDLMAARITIKAIKEAGSLQNLKTYLLNIDKIPDPTEKFFTDNVHDSSKYSTVYSLVHDVSFREKSEVDGLSISSAYILHAFALSSNLLGDGINDIRDCANNEWALFLGALILRNIRISSLNCFSVRKKNLSTPFIDMKRGDLLGSFASFFNHSCFSNVCPAHYGNTMTFRASQQIKKGAQLFISYGSSFDETPTLQRREQLKDDYNFWCECIACRYDWNPASIFPTLVNKRSLSEIELKIKELIQKNDKKALTTMQQSSKSNTWNDNSHTLQSLCDLLNLMCENLDYRSREMLSFKILLESNYVHDADTYNDNCYIVKCT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HP92</accession>
    <name>A0A8J2HP92_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similar to jhamt: Juvenile hormone acid O-methyltransferase (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS13384</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5108732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HP92"/>
    <dbReference type="OrthoDB" id="8300214at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013217">
        <property type="entry name" value="Methyltransf_12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43861:SF1">
        <property type="entry name" value="TRANS-ACONITATE 2-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43861">
        <property type="entry name" value="TRANS-ACONITATE 2-METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08242">
        <property type="entry name" value="Methyltransf_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransferase type 12" evidence="1">
        <location>
            <begin position="40"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5108732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="286" mass="33091" checksum="0924A6A465C18B63" modified="2022-05-25" version="1">MEKAFDSESYIDAYSLQRRDACEIIEEFADEISSMYGKCIDIGCGPGHVTKELILPKLPAESVVVGADISDSMIESAKKKHCDEKRLSFLKLNIETDELPIKEIEKYDNALSFYCLHWCQDMRLTLKNIYQLLRPGGRSLVMFLSYNSGFDAFIKFQTNPRYKSYMEDVLKYVPPFQSCSNPRASLKKILEEVGFEVLHCSNREKTYVFANMEILQKHVIAINPFLNRIPENLRDEFNTAITKEVAEHKIIFESHKNKSTGYSVLDRYEVLIAYFRKPLNSFSKII</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HPB5</accession>
    <name>A0A8J2HPB5_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS12862</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5107675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HPB5"/>
    <dbReference type="OrthoDB" id="10295226at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5107675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="177" mass="20209" checksum="6C7C47BE84085175" modified="2022-05-25" version="1">MPFYSDFLAMEVDETVGQSQTNCFKYQSNEEFHEKFDFHVSESGWSSSNPSSPESPNLNRNFYKRKGQSHSRDIYRTNYAQKVPKNSGLYSPGSFTGSINSPNSSLEKSFIRTGQESTLCKENQFLIGLKPSERISYIREILPVQNQSGYTSRSKWELMAPPKAPLRRPHSPSSHLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HQ92</accession>
    <name>A0A8J2HQ92_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS12185</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5106288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HQ92"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5106288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="128" mass="13336" checksum="EC84F386245ECC9E" modified="2022-05-25" version="1">MPHNVSHSTSVFNAGPTGGSNINPTSPMSLISSVPSPGSTSNNSQSPYGTNGLPETPPPAYLPPDDGSQTVQSPPPDPAAMDTTGYSDNKLNPERLKLHTGALLTADKDVKVSVLSIFIARLGKILHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HQA2</accession>
    <name>A0A8J2HQA2_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Similar to Zasp52: PDZ and LIM domain protein Zasp (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HICCMSTLAB_LOCUS13243</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5108450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HQA2"/>
    <dbReference type="OrthoDB" id="44841at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005912">
        <property type="term" value="C:adherens junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031941">
        <property type="term" value="C:filamentous actin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001725">
        <property type="term" value="C:stress fiber"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030018">
        <property type="term" value="C:Z disc"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051371">
        <property type="term" value="F:muscle alpha-actinin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061061">
        <property type="term" value="P:muscle structure development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23068">
        <property type="entry name" value="PDZ_ZASP52-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.42.10:FF:000055">
        <property type="entry name" value="PDZ and LIM domain protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050604">
        <property type="entry name" value="PDZ-LIM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24214">
        <property type="entry name" value="PDZ AND LIM DOMAIN PROTEIN ZASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24214:SF38">
        <property type="entry name" value="PDZ AND LIM DOMAIN PROTEIN ZASP-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0440">LIM domain</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="PDZ" evidence="6">
        <location>
            <begin position="5"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="131"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="295"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="459"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="404"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="131"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="142"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="318"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="462"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="495"/>
            <end position="508"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAG5108450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="712" mass="80649" checksum="1086A3B1B8D897EF" modified="2022-05-25" version="1">MSIIDIKFSKFDNTPWGFRLAGGSDFPQPLTVIRVVEGSLAECMGLKLGDVVVRLNDRPVASLTHGQAHEALMLAGNNFTLGVSRKHEATEVVENLQSDTVPYRIPLEDLKPLEVIPLEDPWELVSKKLNQEEKEEQGDKVTDEEEASKELEELEQSVAEKPVDANSEVVPNKNLTDEEIAELIVEEEELLDVGDQGVLGVNFKKLRPRAPLLKESKVLEELQTIALEEPPRVKELKHKSTFLQKPERPIPTKKSLIEEVVVDQSECYRVVIKKQPKKSVTERLLEKGLLDKASAEALRSAPSKSPTLDQSSQQKTTSSEEEKTHHVESSENETRREEYQLSESRENLYEEESCAEICNEKAESVDNIEDHTERLSTNRCETPDIKVQTPEPIVEPIVFDREKVKELVSTEISLEKQLENVQNQLLALKQLPAEIENHLKVVSEQLYKIMELSGVKNGNQECKAEPEKREEERAETPESCHEEEETHSEADKNDTSIAETMSTMSNKAPSISIEEEIEPPETKELEVTIKSEDRRVKKCIASYETRVFRSTPSPAPSYGSYEADSNLSPRDQVIQELKQRGGRKRSKDLWPQAKQLELTYGRRWRCPNDFFNDEMIAEVLSGQAEVIRGRAMGVNFKKYEKSWLPNYDHLMNSSVYKMLHKMEREPRTGIPARPPKVVAAEDIIERVHPSVVDRGAVCAVASQPPPNSTNRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HQD1</accession>
    <name>A0A8J2HQD1_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Similar to aurka-a: Aurora kinase A-A (Xenopus laevis)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HICCMSTLAB_LOCUS12533</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5106996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HQD1"/>
    <dbReference type="OrthoDB" id="377346at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030616">
        <property type="entry name" value="Aur-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24350">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE IAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="1"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAG5106996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="147" mass="16729" checksum="C41D64A19072D221" modified="2022-05-25" version="1">MSKTNNVMVMPKDVPTDFISGVQEATNIMEEHVGSHPNGRNTMCGTLDYLPPEMINGQSYNIFVDNWCLGILCYEFLVGEPPFLSDNQHETYKKIRTADIIYPLHISPEARDLISKLVKKQSSERIPLSAVKKHLWVVKNKEKAKLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HQM4</accession>
    <name>A0A8J2HQM4_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Similar to APOD: Apolipoprotein D (Macaca fascicularis)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HICCMSTLAB_LOCUS13733</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 3 4">Belongs to the calycin superfamily. Lipocalin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5109097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HQM4"/>
    <dbReference type="OrthoDB" id="565904at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031409">
        <property type="term" value="F:pigment binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000302">
        <property type="term" value="P:response to reactive oxygen species"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012674">
        <property type="entry name" value="Calycin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003057">
        <property type="entry name" value="Invtbrt_color"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022271">
        <property type="entry name" value="Lipocalin_ApoD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022272">
        <property type="entry name" value="Lipocalin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000566">
        <property type="entry name" value="Lipocln_cytosolic_FA-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10612">
        <property type="entry name" value="APOLIPOPROTEIN D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10612:SF49">
        <property type="entry name" value="APOLIPOPROTEIN D-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00061">
        <property type="entry name" value="Lipocalin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036893">
        <property type="entry name" value="Lipocalin_ApoD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01273">
        <property type="entry name" value="INVTBRTCOLOR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50814">
        <property type="entry name" value="Lipocalins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00213">
        <property type="entry name" value="LIPOCALIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035350786" evidence="3">
        <location>
            <begin position="21"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="Lipocalin/cytosolic fatty-acid binding" evidence="5">
        <location>
            <begin position="43"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR036893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAG5109097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="188" mass="21406" checksum="6743D469624192E6" modified="2022-05-25" version="1">MSALFNCCVLFFCLVVGSFAQISQLGSCPAVQPVQNFQPQNLSGMWYQVRRYDNFYDINERCNRVNLTIESGNRLRISERSVNTLSGEPITTNLTLTPVNRAQAQYRVRLSVFSRQTSLVTLLDTDYSSFAIFYMCQDFANTRLVYLWLISRQRTLGLNTLGRRLRVEAANNLPIGELRTVGQLNCPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HRB6</accession>
    <name>A0A8J2HRB6_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Down Syndrome Cell Adhesion Molecule-like protein 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HICCMSTLAB_LOCUS13865</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5109229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HRB6"/>
    <dbReference type="OrthoDB" id="5969272at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098632">
        <property type="term" value="F:cell-cell adhesion mediator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007411">
        <property type="term" value="P:axon guidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007420">
        <property type="term" value="P:brain development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000230">
        <property type="entry name" value="Down syndrome cell adhesion molecule, isoform D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000310">
        <property type="entry name" value="Down syndrome cell adhesion molecule, isoform D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44170">
        <property type="entry name" value="PROTEIN SIDEKICK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44170:SF58">
        <property type="entry name" value="PROTEIN TURTLE HOMOLOG A-LIKE ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035182386" evidence="3">
        <location>
            <begin position="35"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="4">
        <location>
            <begin position="41"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="4">
        <location>
            <begin position="307"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="4">
        <location>
            <begin position="432"/>
            <end position="508"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAG5109229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="725" mass="81697" checksum="93111C7944D19E55" modified="2022-05-25" version="1">MGLLRMLREPPGGHDINLIMFCMVSFMFFNLVLAEDELMGPVFVKEPPNRVDFSNGTGAEVECQARGNPQPDIIWVRADGTAVGDVPGLRQVLPNGNLVFPPFRAEDYRQEVHAQVYSCLATSPAGSVHSRDVNVRAVVAQYYDTDVNKEYAIRGNSAILKCVVPSFVADFVKILSWHTDQGEEFVPGDDYVVHQYYQSEVNNEYVIRGNSAILKCSIPSFVSEFVQVVGWQDDQGNSFNPNEENVVVQYYEAEVVSEYVIRGNAAILKCTIPSFVAEFVSVESWEGSDGSRYKPSTDYVVAQTYQPEIMTEYVIRGNSAILKCSIPSYIAEFVSIEAWIREDGEVYVPEYQQTDKIPQVVSQFFVTEAENEYVIRANSAIMKCKIPSFVSEFVYVDQWIADDGTIYRHEDQDYVVQQFYESRVIDEFVLRGNTATLKCLVPSFVGDFVDVIEWIADDGTSYSADSREEEVVSQYFEVQVYDVFAIRGNAAIFKCQVPSFVADHVDVDGWIDSAGGNYRADDEQMSYVVGQRYAVNVMDEHVLRGNAAIIKCHIPSFVAEFVEVDSWVEDETTEIYPKSNYDGKYLVLPSGELHIRDVGPEDGYKTYQCRTKHRLTGETRLSATKGRLVITEPVTSTKPKFPMTENSRTYTVRSNEPLTLFCPAQAFPVPAFRTCHQCETKISDDGHIAHIYSLSWQNADTFLSGSSLSRSSFQNQSRVLSQNSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HSC2</accession>
    <name>A0A8J2HSC2_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Odorant receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HICCMSTLAB_LOCUS13793</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Cell membrane</location>
            <topology evidence="1 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the insect chemoreceptor superfamily. Heteromeric odorant receptor channel (TC 1.A.69) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5109157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HSC2"/>
    <dbReference type="OrthoDB" id="7539170at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005549">
        <property type="term" value="F:odorant binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004984">
        <property type="term" value="F:olfactory receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004117">
        <property type="entry name" value="7tm6_olfct_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21137">
        <property type="entry name" value="ODORANT RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21137:SF35">
        <property type="entry name" value="ODORANT RECEPTOR 19A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02949">
        <property type="entry name" value="7tm_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 10" id="KW-0552">Olfaction</keyword>
    <keyword evidence="8 10 11" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="9 10" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="33"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="128"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="191"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="258"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="287"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU351113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAG5109157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="382" mass="44137" checksum="96AA1118544B1C7C" modified="2022-05-25" version="1">MALDRQLEFVKFRSIMKKLVFIVGLWTNEDSSLFYRSLLAIYLSFFLIPIVGVGNFFITNISNISLVTRSLSTLLGFSTVMMKATCFIINRKEVDDLHTVLDPYFDKLVQSPKMSNLVLSNVRTFRRWPIFITVFVTIVCLSYAINPILSIIHQLRHREWPIKYNLIFLTVYPIKARRNSLLYNFYFVDEYLLTASMIFITSSLDSLFTYYIFQLIGMLREISYHISRVDEKNSEIIIRRCVDKYEILLRACGQVQKIYGPIILWTMNVNAVVLCAAIFQLSHAKTIPVVSLILFSAHASLKLIQVYVFAWSGTQLTIESEKFRDCIYAANWTGNMRLKASIIIMLAQKPLILTACNILNVTIDMFVINTSVSCFLLLKTFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HSP4</accession>
    <name>A0A8J2HSP4_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Lipase maturation factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HICCMSTLAB_LOCUS12604</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Involved in the maturation of specific proteins in the endoplasmic reticulum.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Endoplasmic reticulum membrane</location>
            <topology evidence="1 8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the lipase maturation factor family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5107136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HSP4"/>
    <dbReference type="OrthoDB" id="434126at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051604">
        <property type="term" value="P:protein maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009613">
        <property type="entry name" value="LMF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057433">
        <property type="entry name" value="LMF1/2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057434">
        <property type="entry name" value="LMF1/2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14463">
        <property type="entry name" value="LIPASE MATURATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14463:SF5">
        <property type="entry name" value="LIPASE MATURATION FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06762">
        <property type="entry name" value="LMF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25179">
        <property type="entry name" value="LMF1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="25"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="82"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="114"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="140"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="182"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="231"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="314"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="356"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="397"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="637"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="domain" description="Lipase maturation factor 1/2 N-terminal" evidence="9">
        <location>
            <begin position="138"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="Lipase maturation factor 1/2 C-terminal" evidence="10">
        <location>
            <begin position="448"/>
            <end position="588"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF06762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF25179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAG5107136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="663" mass="77150" checksum="4222AFCC318BE0D5" modified="2022-05-25" version="1">MTGVVVGKSQVKSNRMIEVRYTRNLFLRGICIIYLFAFVSFYVQIPGLYGDNGILPARTQIDLKDKSSCLEKFKQKPTLVWIAPYLGLNVEYTLDLIALSGVVLSFLGFISQRFCVWPTFMSLWALYFSLYQVGQTFMQYQWDTLLLETGFLSILIAPFWVPKKAKISTPSDTVTFWCVRWLLFRFMFSSGVAKLASGCPVWWNLDALSHHFEVQCLPGVLAWFAHHLPSWYLRLTTVTTNVFELGIPFLYFFPNRKVRLVAFYIQIYQYLHIMATGNWNFRDLLVICLSIGLLDDQFFYKRKSKQESSRWTNHLSTFVCLVVYAAVVYATIVLYKIRLLDNWTIHTEIGFTQQQFTYYLNKVILASFIIGIISLGFTVADSITHSLLITKGSLNTIITFITTVFYTVAVCLIFGTSLVPFSSLDPSHNITIPPQIKQMYMKVEPYRISNGYTLFRRMTGIDGRPEIIIEGSNDIEGPWREYEFLYKPGNVNHSLSFVAPHSPRLDWQMWFAALGTYHNNPWIMSLTYRLLTNQKEVLSLLNTVEKPFGDKPPKYIRGNLYHYHFVPWKNSWNRESWWTREKVGEYFPIFSRDHPPLLEYLKKLNILQDKPTIKITNKMMKTVLDYMRMVTEKIEPSLLVWSIFIAGCAIIMTTKTTPQSKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HUF3</accession>
    <name>A0A8J2HUF3_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Similar to SPATA5: ATPase family protein 2 homolog (Homo sapiens)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HICCMSTLAB_LOCUS13862</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5109226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HUF3"/>
    <dbReference type="OrthoDB" id="27435at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19511">
        <property type="entry name" value="RecA-like_CDC48_r2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000018">
        <property type="entry name" value="Cell division control 48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050168">
        <property type="entry name" value="AAA_ATPase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077">
        <property type="entry name" value="AAA-FAMILY ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077:SF27">
        <property type="entry name" value="ATPASE FAMILY GENE 2 PROTEIN HOMOLOG A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="4">
        <location>
            <begin position="294"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="4">
        <location>
            <begin position="557"/>
            <end position="698"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAG5109226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="792" mass="88349" checksum="F294B006225E1669" modified="2022-05-25" version="1">MSKSRKSLSTLWVTCDKCRSTMSQKDTCFHESTCPPKNDEWTHHYIQNKILYSSVDAYCSKELPKNITERDSHEMVFMSHSALELCEIAIGDRVILSFKGEEIVKTAWPTSDRSLTSVCLTKNTMDVNKVSGPVTVRKLKNQLLSAEEITIKYVGRQQLPKITSELQILFKNYNERKVFCIGNRINIPFYGKNLPFIIVSITQGKHNNSSLNTSSNDDLADGLESMSITDPKFFLSLFTTKWRVIKDEINSTANKKSKITANDIGGYDKLLNELRDIVDVVLGKCRQVLKGIRISKSILLYGLNGVGKTTIANVLLSSYDVKVFSFKASEIYTKYLNDENKKISDLFAEAKAETSSVIFIDDIDTLFTKKGLSDGEKRFLGTLIQEIDDLQESDANTLLLMTTSKLDSIDSSLRRSGRLDREIEIPTPTPSMRCEILKKLISKMPNTFNDDDFDEIAYVTHAFVAADLNVLCSQAGMRAIKRHQDNDLTPNVYVSAVDFMGALRTVKPTAMKEISVEVPNVKWSDIGGQKSLKLKLCQAIEWPLKNPDVFIRLGITPPKGLLMYGPPGCSKTMVAKALATESKLNFINIKGPELFSKWVGESERAVREVFRKANEVAPSIVFIDEIDAIGGERATGDAANASNNVQERVLAQLLTELDGVTALGNVTLVAATNRPDRIDKALLRPGRLDRLVYVPLPDADTRGEIFKIKFLKMPVDEDSVKIPDLVEITDGYSGAEIQALCHEAAMSALQEDINSNVLLTKHFADALKIVKPRTSAKLITLYENFCNNTNNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MAA3</accession>
    <name>A0A8J2MAA3_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Similar to Dbp: D site-binding protein (Mus musculus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HICCMSTLAB_LOCUS2697</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bZIP family. NFIL3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001117">
        <property type="protein sequence ID" value="CAG5078279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MAA3"/>
    <dbReference type="OrthoDB" id="6022300at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14695">
        <property type="entry name" value="bZIP_HLF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.170:FF:000025">
        <property type="entry name" value="nuclear factor interleukin-3-regulated protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040223">
        <property type="entry name" value="PAR_bZIP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11988:SF55">
        <property type="entry name" value="BZIP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11988">
        <property type="entry name" value="THYROTROPH EMBRYONIC FACTOR RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07716">
        <property type="entry name" value="bZIP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BZIP" evidence="8">
        <location>
            <begin position="25"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAG5078279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="167" mass="19254" checksum="DCC7AC1272BB79F9" modified="2022-05-25" version="1">MMNCLSERKKYQRSEKKAISDDKKDDKYYERRKRNNEAAKKSRDARKLREDYTAMRAKLLENENGILWKKIILLCQEIETLHEVIRKIQRYVPTDKADDDCSMNLNQWEAIFNGRKSLYCKTIPEYPSSSSSSSTSSIVNNNSGSVTALTVISRLSSILHSPPQSAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MCN3</accession>
    <name>A0A8J2MCN3_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">AP-3 complex subunit delta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HICCMSTLAB_LOCUS3257</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the adaptor complexes large subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5081344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MCN3"/>
    <dbReference type="OrthoDB" id="10264595at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030123">
        <property type="term" value="C:AP-3 adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904115">
        <property type="term" value="C:axon cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098830">
        <property type="term" value="C:presynaptic endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043195">
        <property type="term" value="C:terminal bouton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048490">
        <property type="term" value="P:anterograde synaptic vesicle transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006896">
        <property type="term" value="P:Golgi to vacuole transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098943">
        <property type="term" value="P:neurotransmitter receptor transport, postsynaptic endosome to lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016182">
        <property type="term" value="P:synaptic vesicle budding from endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048499">
        <property type="term" value="P:synaptic vesicle membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000251">
        <property type="entry name" value="AP-3 complex subunit delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017105">
        <property type="entry name" value="AP3_complex_dsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010474">
        <property type="entry name" value="AP3D_dom_metazoa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002553">
        <property type="entry name" value="Clathrin/coatomer_adapt-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058898">
        <property type="entry name" value="Mu_AP3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22781:SF12">
        <property type="entry name" value="AP-3 COMPLEX SUBUNIT DELTA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22781">
        <property type="entry name" value="DELTA ADAPTIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01602">
        <property type="entry name" value="Adaptin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06375">
        <property type="entry name" value="AP3D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26171">
        <property type="entry name" value="Mu_AP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01354">
        <property type="entry name" value="BLVR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="AP-3 complex subunit delta" evidence="9">
        <location>
            <begin position="657"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="650"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="722"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="857"/>
            <end position="912"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="661"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="725"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="784"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="824"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="857"/>
            <end position="866"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAG5081344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="1170" mass="131184" checksum="CBAA3610AA4061EF" modified="2022-05-25" version="1">MALRKVKGNFERMFDKNLTDLVRGIRNNKNNEAKYITQCIEEIKQELRQDNVAVKANAVAKLTYLQMLGYDISWAGFNIIEVMSSGKFTYKRIGYLAASQSFHMDTELLMLTTNMIRKDLNSQNQYDAGLALSGLSCFISPDLARDLVNDIMTLLTSTKPYLRKKAVLMMYKVFLRFPEALRPAFPRLKEKLEDPDSGVQSAAVNVVCELARKNPKNYLSLAPIFFKLMTTSTNNWMLIKIIKLFGALTPLEPRLGKKLIEPLTNLIHSTSAMSLLYECINTVIAVLISISSGMPNHSDSIQLCVQKLRILIEDSDQNLKYLGLLAMSKILKTHPKSVQAHKDLIMQCLDDKDESIRLRALDLLYGMVSKKNLMEIVRKLMIHMDKAEGTTYRDELLSKIIQICSQNNYQFITYFEWYISVLVDLTRMEGTKHGQLVATQLLDVAIRVQAIRKCAVQQCALLLENAHLLTGQPRATMCEVLYAAAWICGEFCSELDDPIATLKSMLKSQASSLPGHIQAVYVHNILKLAAITLNKAYVEEDLEKIDQIFELKDKMAEFVCSGDLEVQERSSAVLILFDYLKENPALIPELAATFEGELNPVAPKAQKKVPIPEGLDLDTWINDPPSETSDEEDLDMNDIFVKSEKSEYAGRKVSVEPTAEELQKRREARKLEQENNPHYLKTTASPKNNSDYDHIPITELDIPVELKVNSFSNSKLLNLSDVDKKRRKVHGKKKKKSKKNKNQSSSDDDLDGGYPTHFVNTGVGELPPGAELSDNDDTNLTDANDPHRALNIDLDVPLREDERLPVPEHRAVLGGKKKGEKERAKKKKKKGKKGSQNDGLNNIDLWLGNDAVDKENDKVVDSDEKGKSKRSKAKKKDAEDSRRRKKKHLEGKKQKPSGYEETAGISTPSKEILPGLASNCDEIRGGNDSGNVYEFQGYLELASNDKVKMTYELKQLPHEVGRIIAVVTLSNCGNKLLKELDLDVSDASSLKLVRSLGEESGIKIRVPLAASASTEVHLPIIVADDTYAQKLRGALTYMVENSGGWIQEKLDFTLRLSNCSFLMGSLSHSYVFTELLSGDQLMFKTKNKVKLTRNFSQALEIICRRCHFTLVEQVDDNASLYGQSLKGHHVCLLVKKKSSDNSSCLIIEGKGDNNSLLSGVVNEIIEVLAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2025-02-05" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2ME32</accession>
    <name>A0A8J2ME32_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS4324</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5085263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10382244at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.950">
        <property type="entry name" value="Methyl-accepting chemotaxis protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032062">
        <property type="entry name" value="DUF4803"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47890">
        <property type="entry name" value="LD24308P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47890:SF1">
        <property type="entry name" value="LD24308P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16061">
        <property type="entry name" value="DUF4803"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035213078" evidence="1">
        <location>
            <begin position="21"/>
            <end position="1392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5085263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="1392" mass="158847" checksum="A63EAB4D189F63BA" modified="2022-05-25" version="1">MTKLLLLVVVLCTTTNYASAKGFSTTKLSGFMAISQDLYSGISDTVKSFKQTSTKAPPDANNKLKKIDDATKGLGETSKKLNTSLTNFKEATDVIIENLDEIGGKVDDIHDVAEVMLRRLDKVVQNLARITAEFTKIPKAVTNKMEQMLNLILKQQATQQTMDNQLLQLWQHTTNIDTWYEKFLIVINPDRPLQQATYDRFYEIVTTKENDGMDKTIKYIHAMFTTGTGNSSIHDNILEFVNIYQKQLGFESKCDLQRSFQEQLRVIYNIVVVSELRVFMMKVFVHHRKRIETKNYKNDLKIAVEESLTRMSGYLQAMKLATKRSSAEIFRCDPPNPVINDDVFRLDGLFGLYYFNVQQISSDCEIKDLKIIDFQGHVDSLDLTQSGAYVQSYRPRYQCHGRIHKCFEGGKRTFCEARLGTGKRYEWMSNKNTTYHDCNGRYIDTLAKALCADVICQCSEEGPESTATRAFNLRPQYSDVKKNKVVTNVKLRKKDNVVHIQIQQGILQAEGRVDEDSLEWVPLGKFIRSVSEDEEGFHWTDNEELWPLVEDQDYTYVAHDRAELNLDDILVETGYIVTGVKFERQNLNPRQGLNMSPLRLKVHGTKFNYVEGKLSIPTDAQELKLDDRRYFKDKISMEGKRDSMLSGGNRIDARPNSAVEFQPTNFDTDFGQTTIPYFDARPAIIVDGVALGGIALTHRGIPGYGGYVAPKVFSINHAEYIEIDIDDISAAASEIVENLRNEEDSNSIYKLGLLMNDTNLVARHVIGDHLIALSESMKKSLDPLIEAHNDSWDFNDVTTKLVNSFGQFDQFFETFVALVAYDTSENSIDNQLNRDMVENFVSEIIKENKLENIITSIYEAVTPSESNNTFSFLSDYLKQFDENFKNYQRCDFTIPVQDSIKNVYDLVVLNEIRGFAMILFALNYQQITSEVANENTISEKISNFIERVHTTLGISKTLTYNARIDLLACDPNQHVLDETCFRLEDLFTKYFANERQLSDTTDVNFKYFSTYNRIECLDETNNKNELQLKYYCPERQCFGKIHDCRTVNPMSAFCESLNPSGPRYLWAVDKYNSSDIENCPGEFIDTMTKSPYRSLMCQCSEEGAESEATRAINMNPQMADINNNMVVTNVKFLKQDNMIHLQIEQGALLPEAKIDPDTVETVPVGRFRYLKNTDNGSFVMINPSDHDDEIYLKYDTNYTFITHDHNVLHLDEINVDRSYVVTGVRLRNSEFNPENGINTSPIELQVHATKFDYHKGVLRPDLSKGTVWMTPKNLDNRPGYTSGRQLLDLSNMEDSMTEEFVNVVDSLPNQEIEFQPSAVSGNLGQTTIPYFDARAPAVNNLRALKGVGIIHRGVDGFGGFLAPKLMTVDHTEYALANVKASDRKKWMKEWLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MJW4</accession>
    <name>A0A8J2MJW4_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Complex I-B12</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">NADH-ubiquinone oxidoreductase B12 subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">HICCMSTLAB_LOCUS8119</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
            <orientation evidence="2">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the complex I NDUFB3 subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5096257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MJW4"/>
    <dbReference type="OrthoDB" id="521512at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022900">
        <property type="term" value="P:electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032981">
        <property type="term" value="P:mitochondrial respiratory chain complex I assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012576">
        <property type="entry name" value="NDUFB3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15082:SF2">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 BETA SUBCOMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15082">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE B12 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08122">
        <property type="entry name" value="NDUF_B12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0249">Electron transport</keyword>
    <keyword evidence="12 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="7 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="66"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00030217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00032688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CAG5096257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="111" mass="12643" checksum="C5BC710A6CC9C713" modified="2022-05-25" version="1">MGGHGHHHGPPPDPYRIPNASEYDTISHPELIRFQQRLAKHGLKDPWIRNYNWRFDKKYGTKMSRLGSLVFCGVPLGVGMFIATLGIEKAFGIDWHAHHHAHEEGHGEAHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MLJ4</accession>
    <name>A0A8J2MLJ4_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 13">Histone H4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">HICCMSTLAB_LOCUS6424</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="1 13">Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5 13">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 13">Belongs to the histone H4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5092895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MLJ4"/>
    <dbReference type="OrthoDB" id="7678123at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22912">
        <property type="entry name" value="HFD_H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000012">
        <property type="entry name" value="Histone H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001951">
        <property type="entry name" value="Histone_H4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019809">
        <property type="entry name" value="Histone_H4_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004823">
        <property type="entry name" value="TAF_TATA-bd_Histone-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10484">
        <property type="entry name" value="HISTONE H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02969">
        <property type="entry name" value="TAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00623">
        <property type="entry name" value="HISTONEH4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00417">
        <property type="entry name" value="H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00047">
        <property type="entry name" value="HISTONE_H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0007">Acetylation</keyword>
    <keyword evidence="7 13" id="KW-0158">Chromosome</keyword>
    <keyword evidence="10 13" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-0488">Methylation</keyword>
    <keyword evidence="12 13" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="11 13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TATA box binding protein associated factor (TAF) histone-like fold" evidence="15">
        <location>
            <begin position="58"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="14">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00020836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CAG5092895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="98" mass="10929" checksum="DA5A7393924C485B" modified="2022-05-25" version="1">MTGRGKGGKGLGKGGAKRHRKVLRDNIQGITKPAIRRLARRGGVKRISGLIYEETRGVLKVFLENVIRDAVTYTEHAKRKTVTAMDVVYALKPGFYYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MM30</accession>
    <name>A0A8J2MM30_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Similar to ANK1: Ankyrin-1 (Homo sapiens)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HICCMSTLAB_LOCUS7669</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ankyrin SOCS box (ASB) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5095358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MM30"/>
    <dbReference type="OrthoDB" id="194358at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045732">
        <property type="term" value="P:positive regulation of protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051573">
        <property type="entry name" value="Ankyrin-SOCS_box_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24136:SF15">
        <property type="entry name" value="ANK_REP_REGION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24136">
        <property type="entry name" value="SOWAH (DROSOPHILA) HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="4">
        <location>
            <begin position="41"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="4">
        <location>
            <begin position="71"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAG5095358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="262" mass="30225" checksum="A643938B9CA6E5B4" modified="2022-05-25" version="1">MVKFLLKNNADVNVKTNRDKVTACRLSRGMYDHYDRKFVMTPLAIAIDKKNISLMELLIDAGAHVNSINLDDVSPLYLAMRIGKVQVMEFLIDHGADFDNIVGTQGYCSLPFEEFGEIERYRYFAKLEALSLFPGPYSEVIDTKFDIFIKKCYEEIKKLKEVDINIHKITFFDVLTMCQHKLAVKLTCVSKVNLARLKTKAKLTFPLYGELVKHYLTKAAQRKNLLMKANATLIDIFGKALPSTFRRQMYYYFSDQDLELLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MM74</accession>
    <name>A0A8J2MM74_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS7789</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5095599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MM74"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5095599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="153" mass="17769" checksum="C2D49AD473D6E0E9" modified="2022-05-25" version="1">MLNELARKIDFHSEREKPRKRIIVSTGNTSRVCGQDRKLKNSFVPYHSSHLDSCEDTKRFICSTNSLIPVLFTRCFTRIYFEKLSPHEAPGGIWVVLTVISGEKEMFNSQTSESFERNHRSLTVVLAYFVTQELIDKINDCNFDNSSWRSGWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MM87</accession>
    <name>A0A8J2MM87_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">MULE transposase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS4038</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5084185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MM87"/>
    <dbReference type="OrthoDB" id="124789at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052579">
        <property type="entry name" value="Zinc_finger_SWIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048324">
        <property type="entry name" value="ZSWIM1-3_RNaseH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048325">
        <property type="entry name" value="ZSWIM3_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31569">
        <property type="entry name" value="SWIM-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31569:SF4">
        <property type="entry name" value="SWIM-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21056">
        <property type="entry name" value="ZSWIM1-3_RNaseH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21599">
        <property type="entry name" value="ZSWIM3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ZSWIM3 N-terminal" evidence="2">
        <location>
            <begin position="9"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="ZSWIM1/3 RNaseH-like" evidence="1">
        <location>
            <begin position="203"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF21056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF21599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5084185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="410" mass="48139" checksum="7E78E198CE8D1158" modified="2022-05-25" version="1">MDIEKVFYVGRQFGSYQAWQEIFEDYNKKNNQVFTIWDCHLLNESSNIDQSIIDTFKYSYVKFKCKFGPSRGSQATQRQTSTCKMNCPSYFLISLKNFRYFEITGLHLEHKYHEESKLVRLHLVVLFRTVQCRFYECIPEVNKLTKEEEIMIGKMLKLNADKKQVQVMIQKELRKIVPLKKLHNINSQVNSGNNDLEAVVQLLRDSYRADVHIYKDNETSTCKGIFFSTEEMRSDFKKWPEIVFLDGTYKLTNNDMTLMIFLVEDGTGRGEVAGLAFLSTEERDVLEWMLNTFKKLNLTVSLKFIKYFDTNWHNIREDWCMYSVLKNSLGNTTNNRLESVNGKIKQVIKKNSSMTIAIKNFFIWYASHKTTNLLRTAGQFLKKPNLQFDPDDAEKKYIETLSQYASAKSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MM97</accession>
    <name>A0A8J2MM97_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ubiquitin-like protease family profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HICCMSTLAB_LOCUS6714</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C48 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5093273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MM97"/>
    <dbReference type="OrthoDB" id="8188607at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008234">
        <property type="term" value="F:cysteine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.395.10">
        <property type="entry name" value="Adenoviral Proteinase, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003653">
        <property type="entry name" value="Peptidase_C48_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02902">
        <property type="entry name" value="Peptidase_C48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like protease family profile" evidence="4">
        <location>
            <begin position="7"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAG5093273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="322" mass="36417" checksum="84AE011FE7CB6C91" modified="2022-05-25" version="1">MRKVKEPNNFQADETLSVVWHHQNIPLQNNSYDCGVFVCFYAEQLSMLKTIEKVNTVNMNGFRTQMLRNILESYEQLSTLENAENGQISKEITDQRSTSLSDVYLYQSAHYHQGSLHLFHHQQAGLQCTAIATYAIAALPNHLSSITMKDLDDILIGGDQYYLQCRAVANMDMLNIDELLPTFLVKNKLIVISEKKDVSYGSLLDENPLTCLNDSIVEKIETKQPTIKNDCGYLFITQGKTVAFKHLYLPHSGGHEFFLFNSHAVDNNNCLPEDDSDGKARLFRCCGSLALAKALLAGTNLNCDENYNLWGLYKITFLRSPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MMM5</accession>
    <name>A0A8J2MMM5_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similar to Fam169b: Protein FAM169B (Mus musculus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS9043</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5099397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MMM5"/>
    <dbReference type="OrthoDB" id="8954808at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029625">
        <property type="entry name" value="FAM169"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22442">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22442:SF10">
        <property type="entry name" value="N-ACETYLTRANSFERASE, GNAT FAMILY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="94"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5099397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="226" mass="26782" checksum="8BB1169C866E5458" modified="2022-05-25" version="1">MFCARCEKFQTTLITQDVDIKLNNINGKIQRIDCKLCKNFIAIINDNKVVNIDEKFNGCTENSWRKVINVQDKIIYYILSQIIYRELDTPCHDKFESIYDHADDNDEIFLKWFDSKPVGFYTIKPKGTEIDRINEYSMTTLDTAYIRSQYRNKGLGSEILYDIIKRYPNEDIGFSIPISYGMLRILNKFLIEHKEYRRSFWEIQDGGNEGSVKLIWFILRNQLHNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MMR9</accession>
    <name>A0A8J2MMR9_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similar to Arr2: Phosrestin-1 (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS7700</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the arrestin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5095421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MMR9"/>
    <dbReference type="OrthoDB" id="6500995at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001664">
        <property type="term" value="F:G protein-coupled receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002031">
        <property type="term" value="P:G protein-coupled receptor internalization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.840">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000698">
        <property type="entry name" value="Arrestin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014753">
        <property type="entry name" value="Arrestin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11792">
        <property type="entry name" value="ARRESTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11792:SF18">
        <property type="entry name" value="FI20035P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00309">
        <property type="entry name" value="ARRESTIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5095421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="164" mass="18973" checksum="D7144B278F0386B9" modified="2022-05-25" version="1">MSLFPQAFNLKEATHPISPSINASTFNNQWYFRKESRNEKLILYLINRDLIVNNGKIDKLFGVIKADPEYIKNKRVYGQVTLTFRYGREDEEYMGIKFCTEAIICFAQLYPPCSDSDHQEPSTALQVCLSSLKYIYYDTSINYSICHHQHICTSSICSYVSRPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MN18</accession>
    <name>A0A8J2MN18_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Similar to ADCY10: Adenylate cyclase type 10 (Oryctolagus cuniculus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HICCMSTLAB_LOCUS8046</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5096111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MN18"/>
    <dbReference type="OrthoDB" id="194468at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004016">
        <property type="term" value="F:adenylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009190">
        <property type="term" value="P:cyclic nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07302">
        <property type="entry name" value="CHD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1230:FF:000017">
        <property type="entry name" value="Adenylate cyclase type 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001054">
        <property type="entry name" value="A/G_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16305:SF28">
        <property type="entry name" value="GUANYLATE CYCLASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16305">
        <property type="entry name" value="TESTICULAR SOLUBLE ADENYLYL CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00211">
        <property type="entry name" value="Guanylate_cyc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50125">
        <property type="entry name" value="GUANYLATE_CYCLASE_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="80"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="domain" description="Guanylate cyclase" evidence="6">
        <location>
            <begin position="152"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="Guanylate cyclase" evidence="6">
        <location>
            <begin position="480"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="347"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAG5096111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="594" mass="67510" checksum="BC62C4C5D3EDBA6E" modified="2022-05-25" version="1" fragment="single">MTKRRQSLVYRLHESLVRRIVCNWNYVYNKKNLKKKIPDAHLDELSIYFFALCDAFHTPKINNKSTTRIITFDISIVKKFYHILISKIRLTFILIVYIQLTMARKSFGNVREKRRVSELLKIEKHTEIFASMCPDEILDHYNDYSTREYYTTLMLGDISGFTEITEKYTRSGKSGPSKLTETLNSYIGPIVQEILSHHGDVLKFSGDAFIVMWKLQEGMIMRDMATKAMQTACIIQKHFGTYSTDIGVTLKVKLAIASGKINFTSVGDPQQMSHYIITGKPVWDVKHAETLCRGGDILVAPSSWQWANPSDYVFKILPNRHTLILASSTMWEHSKEDYKDESWISSLDSDKTNSTETIGDDDNPYDKDSSPVVRSVELNEPLEHLAEIRQVVIVFINVVTDSNVKKRTLISIVNKAFKRVCGIVDKLQGCVNKVSLFDKDLMFLCIFGLRGGKQELEAQIGLRCASKLKSALSAFENINSVTVGVSTGMTYCGVVGHTLRREYTVIGMPVNKAARLMVAYTNKVVCDRESFLYSRLESGHFILQEAKHLKGISNVGPVYEFLEQVQVQDSEMTTAVYPLLGRTIQLKLFESLLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MNF3</accession>
    <name>A0A8J2MNF3_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Tyr recombinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HICCMSTLAB_LOCUS9711</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5100638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MNF3"/>
    <dbReference type="OrthoDB" id="7699712at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00397">
        <property type="entry name" value="DNA_BRE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="entry name" value="Intergrase catalytic core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35617:SF3">
        <property type="entry name" value="CORE-BINDING (CB) DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35617">
        <property type="entry name" value="PHAGE_INTEGRASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="DNA breaking-rejoining enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyr recombinase" evidence="3">
        <location>
            <begin position="371"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="230"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="7"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="240"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="281"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="659"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG5100638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="659" mass="74726" checksum="38B7958940297E5D" modified="2022-05-25" version="1" fragment="single">KDPELTCAQNGEVANTDAGTNSNSDVVSQTQKEDDLVQQDPDLDVEILEILGKDPSKKPDDPFKFHAEIKGRWGAWMKEGLAEEVNKSVLSKYLRKGDLYAEPPKINLEIAPALSEITKKRDDHFSETQRCVGSAVIALGAAMSLLLDASDNEVDELKLMEYFSDTGKLLTEIFHQHSIARKSYITPVMKKGVKNLVDFIPLDEWLYGNKLAEQIKEVKTIESACQNLKSADKSVKKPSQRLQFQGNSRSPPANYRQMGTSNQRKTLRFKPKYQRPSQKSGQERTQTKDSEKNSLKQCWSFTKERNYDIHNTDEFKIIEFLTLRFNKGCKYGTLNSDKAAIALVTYENHSEEKLTKRFMRGTFKKRPVRAKYPTTWDANRVHEYIDTMPDISKLNIKIVSGKLVTLMILATAHRLQTIALINIDNIKISESRIEIKVPELIKTSKTGAFQPSLILPFFKQRQSVCVAKTLLQYLDMTKNLTGELKGLFISTVKPYRVVGAQTLGHWVKAFLEKAGIDASFGAYSVKHAAVSKANAEEVDIDTIQRTAGWSKNSSTFARFYNRPIQSSNETFARNAIPYEVEPKVQVVSQLVPVVDLKRISAPVQPFQVRLHRPAPVRVEAPTIATQEKPRPWCLRLLVPPRWRMARKGGMVYSMAMRLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MP03</accession>
    <name>A0A8J2MP03_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Nondiscriminating glutamyl-tRNA synthetase EARS2, mitochondrial</fullName>
            <ecNumber evidence="3">6.1.1.17</ecNumber>
            <ecNumber evidence="10">6.1.1.24</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Glutamate--tRNA(Gln) ligase EARS2, mitochondrial</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Glutamyl-tRNA synthetase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Mitochondrial glutamyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">HICCMSTLAB_LOCUS8969</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>tRNA(Gln) + L-glutamate + ATP = L-glutamyl-tRNA(Gln) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:64612"/>
            <dbReference type="Rhea" id="RHEA-COMP:9662"/>
            <dbReference type="Rhea" id="RHEA-COMP:9684"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78520"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:64613"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>tRNA(Glu) + L-glutamate + ATP = L-glutamyl-tRNA(Glu) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:23540"/>
            <dbReference type="Rhea" id="RHEA-COMP:9663"/>
            <dbReference type="Rhea" id="RHEA-COMP:9680"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78520"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.17"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:23541"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>tRNA(Glx) + L-glutamate + ATP = L-glutamyl-tRNA(Glx) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:18397"/>
            <dbReference type="Rhea" id="RHEA-COMP:9713"/>
            <dbReference type="Rhea" id="RHEA-COMP:9716"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78520"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.24"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:18398"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.17" evidence="3"/>
    <dbReference type="EC" id="6.1.1.24" evidence="10"/>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5097971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MP03"/>
    <dbReference type="OrthoDB" id="428822at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004818">
        <property type="term" value="F:glutamate-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050561">
        <property type="term" value="F:glutamate-tRNA(Gln) ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006424">
        <property type="term" value="P:glutamyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00808">
        <property type="entry name" value="GluRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000045">
        <property type="entry name" value="Glutamate--tRNA ligase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00022">
        <property type="entry name" value="Glu_tRNA_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045462">
        <property type="entry name" value="aa-tRNA-synth_I_cd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020751">
        <property type="entry name" value="aa-tRNA-synth_I_codon-bd_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008925">
        <property type="entry name" value="aa_tRNA-synth_I_cd-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004527">
        <property type="entry name" value="Glu-tRNA-ligase_bac/mito"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000924">
        <property type="entry name" value="Glu/Gln-tRNA-synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020058">
        <property type="entry name" value="Glu/Gln-tRNA-synth_Ib_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049940">
        <property type="entry name" value="GluQ/Sye"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033910">
        <property type="entry name" value="GluRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00464">
        <property type="entry name" value="gltX_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43311">
        <property type="entry name" value="GLUTAMATE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43311:SF2">
        <property type="entry name" value="GLUTAMATE--TRNA LIGASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19269">
        <property type="entry name" value="Anticodon_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00749">
        <property type="entry name" value="tRNA-synt_1c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00987">
        <property type="entry name" value="TRNASYNTHGLU"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48163">
        <property type="entry name" value="An anticodon-binding domain of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 17" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6 17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 17" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 17" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamyl/glutaminyl-tRNA synthetase class Ib catalytic" evidence="18">
        <location>
            <begin position="20"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="domain" description="Aminoacyl-tRNA synthetase class I anticodon-binding" evidence="19">
        <location>
            <begin position="359"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00044142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00044251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00044313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00047689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU363037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF00749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF19269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="CAG5097971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="429" mass="49534" checksum="C27DD73944D27ADF" modified="2022-05-25" version="1">MLRALTVQFIQRRGYSEPLVRVRFAPSPTGDLHLGGLRTALYNYLFSRQHNGHFLLRIEDTDQTRLQPGAMERLRNNLIWAGIIPDEDPVRGGPTGPYIQSKRLEIYQEYVKKLIENDSAYPCFCTEHRLDLLRREAVKARLVPKYDNRCRHLEKDVVKEKLSKGVEHCIRFKLSTEPQGFKDLVYGDFEPTQQEADFVIIKADGYPTYHFANVVDDHLMEISHVLRGVEWLVSTPKHLEIYQAFGWTPPNFAHLPLILNTDGSKLSKRQGDIKVDFYREQGIFPLALINYITHAGGGFDRDSSISCYSYEQLIKQFDINKINTHSSKLNRDTLMELNKLEIVNLLSDNNNTKILVEKVRRLVLETFPDRNNLKTCLKKFSTTNHLEFPKLMKLLRGHLSGLEQGPSVVEMMEILGKDKTLNRLNKHCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MQ98</accession>
    <name>A0A8J2MQ98_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Similar to Znf271: Zinc finger protein 271 (Mus musculus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">HICCMSTLAB_LOCUS10346</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5101273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MQ98"/>
    <dbReference type="OrthoDB" id="7460655at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048598">
        <property type="term" value="P:embryonic morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040029">
        <property type="term" value="P:epigenetic regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045596">
        <property type="term" value="P:negative regulation of cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000100">
        <property type="entry name" value="Zinc finger 45-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000690">
        <property type="entry name" value="Zinc finger protein 354C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001498">
        <property type="entry name" value="Zinc finger protein 404"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000912">
        <property type="entry name" value="Zinc finger protein 660"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000624">
        <property type="entry name" value="zinc finger protein 697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000110">
        <property type="entry name" value="Zinc finger protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1800.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012934">
        <property type="entry name" value="Znf_AD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24394">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24394:SF48">
        <property type="entry name" value="ZINC FINGER PROTEIN 771"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07776">
        <property type="entry name" value="zf-AD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13912">
        <property type="entry name" value="zf-C2H2_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00868">
        <property type="entry name" value="zf-AD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51915">
        <property type="entry name" value="ZAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="3 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="6 12" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="ZAD" evidence="15">
        <location>
            <begin position="5"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="303"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="331"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="358"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="386"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="414"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="443"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="471"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="500"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="528"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="237"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="238"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="7"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="10"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CAG5101273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="596" mass="69070" checksum="B76324DF8C917056" modified="2022-05-25" version="1">MMPDTNCRLCCEKLDKNYSNIFDCQNEGLSLGAKIMICLSIPIHNNDNLPGKICIPCTDEITRFYDFRNKCQSTYYSLIQKYKENVKKPVDSKVNLSLTKDEEVLDEYIINSLEEEPEINDDKTKSDNLESFVTSPENIKTGEEKNLSKKYKCFYCELLFDSYQGAVDHCIECLATKKITNGIDALNKDQDDKETGSDYAEVEFIEDIDFDGEEKNYYEAKAEAEAEENVAEMIENEKEVEDNSENKFEDEDYISSDEPYEDESENQDPKDSSQNILLSKAELNSEVRPKRRYCKKKIYPENYPCPECKKPFSSRSLMRRHFMVHTGERPHRCETCGRRFSQLGALNFHKKLHEDPPYRCDRCSKPFMRPSDLEKHLRTHTGEKPYTCQVCGKNFTQLVAVQQHERVHTGDKPFRCRICGKTFSQSANKSKHEKIHQKGLKPFICDLCGRSFSDNEEMEEHKAGHGGEKVRECDFCGMKFKKFSEVIDHVRRYHTFERPHTCDFCKKAFYSLYSLKQHIMTHTGQKPFACAECPSKFTQKGNLQKHFSRKHPGKVFKDIWNNKDSDLSGLSGLSSLEGFEDCSVDNKSDVDVKIEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MQA3</accession>
    <name>A0A8J2MQA3_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Similar to Luciferin 4-monooxygenase (Luciola mingrelica)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HICCMSTLAB_LOCUS5247</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5089460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MQA3"/>
    <dbReference type="OrthoDB" id="10253869at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016405">
        <property type="term" value="F:CoA-ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096:SF149">
        <property type="entry name" value="AMP-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="5">
        <location>
            <begin position="40"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="6">
        <location>
            <begin position="451"/>
            <end position="523"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAG5089460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="539" mass="60827" checksum="A3C552D96F88D756" modified="2022-05-25" version="1">MALKYQDSQPIYQNGIWKGVRDDLSEGYFKFGERILNQFKQNPDFIGQIDSLTGKEDTYKSMGDRSIRCALWLINQGIRQGDIVGLCSKNQLDCCIPLFASLYLGTICSPMSHKYMDEELVRYYIDTRQPKVMFINQNNADMVVETAKKMGYSMPIIVFGQKDGLLSFADILRAQNNEEVDKFKCTDVKPQDPTIIINTSGTTNLPKGVLHSYGSYANMFKYYKNDEEPSTVIGFYGINTIAGIRTVIRSVIFKATVVVADNLSGRESLELIEKFKVTRLWMTIYTAYRLMKSPDLLNYNLSSVELVAYGGGKSDEEAIKFLQKLFYNADLYSHYGGTEFGTALTKKVDFSKVMSAGRVMANVEIKVVDSKNNKILGPNEEGEVYIRTPKLMTGYWDNPKATADAVDSEGWYHTGDLGYYDTDGDFFFVARINEFISIYTNKTLSSVIVDVIKKVPGVDEVAVVPRLHPDYYEVPMAFVTVAHGMQVTEDDINGAVEKKLPDYMKLRGGIRFLETMPRTDSGKINNMILRAIVKASLEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MRF9</accession>
    <name>A0A8J2MRF9_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Similar to Rpn2: 26S proteasome non-ATPase regulatory subunit 1 (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HICCMSTLAB_LOCUS11132</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5102684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MRF9"/>
    <dbReference type="OrthoDB" id="261572at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008540">
        <property type="term" value="C:proteasome regulatory particle, base subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034515">
        <property type="term" value="C:proteasome storage granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000426">
        <property type="entry name" value="Proteasome 26S subunit, non-ATPase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002015">
        <property type="entry name" value="Proteasome/cyclosome_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048570">
        <property type="entry name" value="PSMD1_RPN2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10943">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10943:SF2">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01851">
        <property type="entry name" value="PC_rep"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21505">
        <property type="entry name" value="RPN2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5" id="KW-0647">Proteasome</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="26S proteasome non-ATPase regulatory subunit 1/RPN2 N-terminal" evidence="4">
        <location>
            <begin position="6"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="297"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="297"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="320"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF21505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAG5102684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="648" mass="71315" checksum="03ACDB8469083729" modified="2022-05-25" version="1">MKMNITSAAGIISLLEEPMPELKVFALKKLDMIVDEFWPEISEAIEKIEILHEDKTFNQHELAALVASKVYYHLGSFEDSLTYALGAGELFDVNARNEYVDTTIAKCIDFYTQQRQLEAEGKVPAGAKAVDPRLEGIVNRMFQRCLDDGQFRQALGLALETRRMDIFEAAIMQSDDVQGMLSYAFQVAMSLIQNRGFRNTVLRCLVNLYRNLGTPDYVNMCQCLIFLDDPLAVAELLDRLSRGTQECVLMAYQIAFDLYESATQQFLGRVLQALRATAPIPSALMVKPIVKPAKAAETSAASSEASTSETPAAPVEETPVEEKTERSVESLTKEEREQQERVDALSSILGGEVSIDLHLQFLIRSNHTDMLILKNTKDAIRVSICHTATVIANAFMHSGTTSDQFLRDNLDWLARATNWAKLTATASLGVIHRGHEQEALALMQSYLPRDQGAGAGYSEGGGLYALGLIHANHGATITDYLLGQLKDAQNEMVRHGGCLGLGLAAMGSHRQDVYEQLKFNLYQDDAVTGEAAGISMGMVMLGSKSTQAIEDMVAYAQETQHEKILRGLAVGIAFTMYGRLEEADPLVTSLCADKDPILRRSGMYTLAMAYCGTGNNQAIRKLLHVAVSDVNDDVRRAAVTGLGFLLFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MS81</accession>
    <name>A0A8J2MS81_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS8981</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5097995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MS81"/>
    <dbReference type="OrthoDB" id="428895at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="129"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5097995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="153" mass="17373" checksum="E8C74B22D8ADB6C0" modified="2022-05-25" version="1">MALIYLDDNDPWITQHDECAKLLDEIMEQLNQRQSKPKASLAFASLSANIRFQMNQYSDHISQLKKKVSEALKLRVITVDEAERRTRQIEQLQSNYVKIKRLYDVKMNPAASERPSLFGNSSSAFAEGGTVGWDDQNDQDQNSKSGALMSCTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MSC1</accession>
    <name>A0A8J2MSC1_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Similar to hth: Homeobox protein homothorax (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HICCMSTLAB_LOCUS12507</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5106932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MSC1"/>
    <dbReference type="OrthoDB" id="10056939at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032453">
        <property type="entry name" value="PKNOX/Meis_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16493">
        <property type="entry name" value="Meis_PKNOX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0371">Homeobox</keyword>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MEIS N-terminal" evidence="3">
        <location>
            <begin position="83"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="26"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="202"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="221"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="232"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="254"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="267"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="311"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG5106932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="358" mass="38305" checksum="8D323C43E8AF2EE9" modified="2022-05-25" version="1" fragment="single">MAQPRYDDGGLHGNYLEGAGGGGGAGMYDPHGTGRGISSLHHSPHMGMAGVHPQYPPPPPQPSQHVLAAATALAASQVTTDVHKRDKDAIYGHPLFPLLALIFEKCELATCTPREPGVAGGDVCSSESFNEDIAVFSKQIRAEKPYYIADPEVDSLMVQAIQVLRFHLLELEKVHELCDNFCHRYISCLKGKMPIDLVIDDRESSKPPELGNGLDGGPRSTADSTSHTDGASTPDVVSTSPSSTSYYPHDAITPHHHHNHHHHAIGSTTPLQLSQNQSQNHPSQQSNNNNTTTPSSAATTPNSHKRSHQQMMMAAAMATSPHATSAPPAHSHSHVALTAYSCHSSTVVYPCSLALHNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MSS2</accession>
    <name>A0A8J2MSS2_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Exocyst complex component</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HICCMSTLAB_LOCUS12885</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="1 6">Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the SEC15 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5107721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MSS2"/>
    <dbReference type="OrthoDB" id="10267033at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000145">
        <property type="term" value="C:exocyst"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006893">
        <property type="term" value="P:Golgi to plasma membrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090522">
        <property type="term" value="P:vesicle tethering involved in exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.357.30:FF:000003">
        <property type="entry name" value="Exocyst complex component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.670:FF:000002">
        <property type="entry name" value="Exocyst complex component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.670">
        <property type="entry name" value="Dsl1p vesicle tethering complex, Tip20p subunit, domain D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.30">
        <property type="entry name" value="Exocyst complex subunit Sec15 C-terminal domain, N-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007225">
        <property type="entry name" value="EXOC6/Sec15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046361">
        <property type="entry name" value="EXOC6/Sec15_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042045">
        <property type="entry name" value="EXOC6/Sec15_C_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048359">
        <property type="entry name" value="EXOC6_Sec15_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042044">
        <property type="entry name" value="EXOC6PINT-1/Sec15/Tip20_C_dom2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12702:SF0">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12702">
        <property type="entry name" value="SEC15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20651">
        <property type="entry name" value="EXOC6_Sec15_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04091">
        <property type="entry name" value="Sec15_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF025007">
        <property type="entry name" value="Sec15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 6" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Exocyst complex component EXOC6/Sec15 N-terminal" evidence="8">
        <location>
            <begin position="94"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="Exocyst complex subunit EXOC6/Sec15 C-terminal" evidence="7">
        <location>
            <begin position="435"/>
            <end position="784"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR025007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAG5107721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="824" mass="95285" checksum="D44E604726E2C6D2" modified="2022-05-25" version="1">MQNHDILIQEIEGIDDYLGPTFRYMRYMKPGCQYFLKSNIIIMSHVSQRPNVLSTSAPKYEHLLFEIESTDTSSVGLVIRAIYDGHEHQKFMEKLDERIKSHDKEIERMCNHHYQGFIDSIRELLQVRSLAQQLNTEILDLDTRISASTTQVIEKGEELVKARKVESNIAAAIDSLTTCLPVLAAYAKLQRQLKDKRYYPALKTLEHLESFDLPKVKNYRFSSQITEQIPLLRENIKDASMSDLRFFLENIRKYSPKIGEVAMRHSAEQLVNESEIIGKKKKKIQQSSTPINEGEDELSAQDLMDFSPVYRCMHIYTVLREGDTFKSYYQQQRHQQARLVLQPPINMHESIIGYQTYLHGIIGFFVVEDHILNTGNGLTTRLYLEELWAMALSKIVNALRTHSAYCTDATLILKIKNLIMLFNTTLRNYGYPVGQLWDLLQEIRVHYNEVLMQHWVQLFRDILDEDNFLPIQVSSQEEYNQILESFPYHDPELEKARFPKKFPFSMMVPKVYHQVKEFIYACLKFSEDLNLTQTEIDEMITKSTNLLLTRTFSGCLSSLFRKPSLALLQVVQIIINTGYLESSTKYLEEFVSNITGTPHDGQLSCGGVKSAMFRVARDDAEKQICDKLERKLDEFLELENYDWILAEPQGHASGFITDLIAFLQSTFTCFTNLPAEVAQVACKSACRHIAEAILNILISEDVKQISMGALQQVNLDTIQCEQFAASEPVLGLPEGILLQYFAQLRQLLDLFMTWDWPTYFHDYGHESSKYHLVTPNMAILLLEKLRESDKKNVFSVLKKSERDKKKLMETVLKQLRQLAQTTSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MT19</accession>
    <name>A0A8J2MT19_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to Elob: Elongin-B (Rattus norvegicus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS13234</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5108432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MT19"/>
    <dbReference type="OrthoDB" id="7537057at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070449">
        <property type="term" value="C:elongin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030891">
        <property type="term" value="C:VCB complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01788">
        <property type="entry name" value="Ubl_ElonginB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039049">
        <property type="entry name" value="ELOB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13248:SF4">
        <property type="entry name" value="ELONGIN B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13248">
        <property type="entry name" value="TRANSCRIPTION ELONGATION FACTOR B POLYPEPTIDE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="2">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5108432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="112" mass="12392" checksum="D55E0608169133DC" modified="2022-05-25" version="1">MIRRKKTTIFTDAKDNTTVLELKKMIEGILKIPPTHQQLFNKENTEMVDGKSLSDYGLNSNSAKAQSPALVGLALLQENGSFEKLEITPYSQPPDLPDVMKSQEANGQEQAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MU69</accession>
    <name>A0A8J2MU69_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Similar to dcaf13: DDB1- and CUL4-associated factor 13 (Xenopus tropicalis)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HICCMSTLAB_LOCUS13221</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat DCAF13/WDSOF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5108406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MU69"/>
    <dbReference type="OrthoDB" id="10249065at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000132">
        <property type="entry name" value="DDB1- and CUL4-associated factor 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:001900">
        <property type="entry name" value="DDB1- and CUL4-associated factor 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007287">
        <property type="entry name" value="Sof1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051733">
        <property type="entry name" value="WD_repeat_DCAF13/WDSOF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22851:SF0">
        <property type="entry name" value="DDB1- AND CUL4-ASSOCIATED FACTOR 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22851">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA U3 SNORNA ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04158">
        <property type="entry name" value="Sof1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 7" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="62"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="105"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="283"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="326"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="domain" description="Sof1-like protein" evidence="9">
        <location>
            <begin position="359"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="418"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="9"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="440"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAG5108406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="450" mass="52002" checksum="08B03CE6509F77EE" modified="2022-05-25" version="1">MKVKTLTRNPDEYLRETKRDLHKQPRNYDPSLHPYEAAREYTRALNATKLERVFAKPFVGNLDGHKDGVSSVCTHPKYLSVYLSGACDGEVKIWNLPTRTCQRTILAHDGEVKGITFASDKEHFITVGNDKSIKTWKYSKAEEEEEEEEEADEPTNTIFSRKILTGITHHRNKPLFATCGEICQLWEETRNEPVKSFQWGIDGLLDVKFNQVQTNLLAACSSDRSVILYDTRDVGPMRKVVMKLKTNQLAWNPMEAFTFTCANEDYNLYTFDTRHLKSPINVHQDHTSAVDTVDYSPTGREFVSGSHDKSIRIYEVNKGHARDIYHTKRMQKLKCVSWSLDNKYIISGSDETNIRVWKARASEKLGVLKPRERMALNYSSALINKFAAHPQIRRIARHRQIPKHIYNAQAELRTIREKQKKKESNRRAHSRPGTVPFVSERSKHVVREET</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MV72</accession>
    <name>A0A8J2MV72_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to sick: Protein sickie (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS8636</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5097295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MV72"/>
    <dbReference type="OrthoDB" id="2161974at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022008">
        <property type="term" value="P:neurogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039041">
        <property type="entry name" value="Nav/unc-53"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12784:SF28">
        <property type="entry name" value="PROTEIN SICKIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12784">
        <property type="entry name" value="STEERIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="286"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="362"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="413"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="17"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="66"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="92"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="306"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="365"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5097295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="469" mass="50398" checksum="10EB34D85B38C66C" modified="2022-05-25" version="1" fragment="single">NNCSTNNSNSNSQQWKKYIEAGAARDRERDKEGAPSSPSPSRRSQDKHRKQAMAEYTNGEKPQKVSSGTSTNSSSKVRGVPQSFGYVKRHSAGTSPSPNGVQNGKDATRTAQVSAVPRTKVKVSGGTQTCTTELQANSAANQGHHYKSYSLTGPSASQLSQSVRDRLMLGSQSLPKPGSPEFTALFASAHHRDRGGSAGPVTAGFSPRVLKPSDGSLSDTCSNYAAPDIQSYYAPNSPYATSWMRHSNTYTPSGRSQGMGLCEADSVESLGSHRTSLSHARLLMHQRDSSGSPAPPRLNRSNSISHLRDRTFPRSTKSEKMYPSMLTRGSGASSSVGEEVGIGIGVGGEPYYSVPVGSAGCAGQHWSQPTSPTPTHASRQPPNLYQHVHKDDDIHGSSVSLVSTASSLYSSAEEKQAHELRKLRRELLDAQEKVHSLTSQLSTNVSYISSLNFKKIYLNLNLAFNLIKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MVN4</accession>
    <name>A0A8J2MVN4_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS10163</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5101090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MVN4"/>
    <dbReference type="OrthoDB" id="21151at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="626"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="635"/>
            <end position="646"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5101090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="646" mass="75488" checksum="F98BC80DD3F43DDE" modified="2022-05-25" version="1">MDEDFDDVVIEGSDLHKALTDVGFTDFESTYVDRKDFNKTEEFPLIVEETSKIDYTWRNFFMSLKQPRKNSYGVQELEIILKLQPLLDDHTLSIQNILKDKSPSRLRYSLWSSIIFSSAIASALAYQQLRTPVIVTCSVISSNLIYSYYCKKSRLDILENLVSTQNNIYLQYKKILKILKNNFCIKLTSKKSQKKFSDLEVPRIKYLLPMCEIFTSSIEVISHSYYKISLSIIKLLSKSSDTKNLFSNFDEDTFNINGEITYERLKQFYYMYILVQSDMMNLLALLHQNDFKNHQYLANKVTKFLLKLLKPYSDKLNKIIEEYKGNTKQVYRQLKKSNVTKWQDLYINVDLLSRKIQSAYNNISLIVDDLDDCADCEETDEFLKSLMEKMNDVYKEIDTARNFAEFNRLLIGKFLNKSVKSKDEDKVPEVAELERVPVVFDEDPEIIDEVFEEYIKEEYLKPLYQDNDADSLERAKLDKLLAKNFMSELKEVLIDKYKSMSEREAQALLRYRKTLRDFKDVDEDTENIKKNEKIISHNEEDKFVEKVHFSLPPPPPPFPIEGDSLEIKRLSRPPIPLPRSVNSPPMNDVRNNKIDNFGSIISVQSEKLINMNRGIKFPGFIDAEEETFVGSGENSDQELIDDDQED</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MWS6</accession>
    <name>A0A8J2MWS6_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Similar to GLRA3: Glycine receptor subunit alpha-3 (Homo sapiens)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">HICCMSTLAB_LOCUS10032</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the ligand-gated ion channel (TC 1.A.9) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5100959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MWS6"/>
    <dbReference type="OrthoDB" id="407674at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005254">
        <property type="term" value="F:chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005230">
        <property type="term" value="F:extracellular ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099095">
        <property type="term" value="F:ligand-gated monoatomic anion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18992">
        <property type="entry name" value="LGIC_ECD_HisCl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19049">
        <property type="entry name" value="LGIC_TM_anion"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.170.10:FF:000024">
        <property type="entry name" value="Histamine-gated chloride channel subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.390">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006028">
        <property type="entry name" value="GABAA/Glycine_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006202">
        <property type="entry name" value="Neur_chan_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036719">
        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038050">
        <property type="entry name" value="Neuro_actylchol_rec"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006029">
        <property type="entry name" value="Neurotrans-gated_channel_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018000">
        <property type="entry name" value="Neurotransmitter_ion_chnl_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00860">
        <property type="entry name" value="LIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18945">
        <property type="entry name" value="NEUROTRANSMITTER GATED ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02931">
        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02932">
        <property type="entry name" value="Neur_chan_memb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00253">
        <property type="entry name" value="GABAARECEPTR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00252">
        <property type="entry name" value="NRIONCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90112">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane pore"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00236">
        <property type="entry name" value="NEUROTR_ION_CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10 11" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8 11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-0675">Receptor</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="322"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="383"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="469"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel ligand-binding" evidence="12">
        <location>
            <begin position="120"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel transmembrane" evidence="13">
        <location>
            <begin position="325"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CAG5100959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="487" mass="56863" checksum="B8AA6B2E9E4C27C9" modified="2022-05-25" version="1">MSRATEHQTFYQTNLDKNLIWFHGFIGMTRYYLTIICCLYTLVDMGSLHFSEKICEPVLSTEVEGWHIKVNSLTSRTIRLSARKRGYRFFPKIQRGVEVEDYGRKEASLSLRDILPLNPKQYDKHRAPKFYGQPTMVYFHVTVLSLDSINEESMTYVADIFLAQSWRDSRLRLPENMSEEYRILDVDWLHNIWRPDCFFKNAKKVTFHEMSIPNHYLWLYHDKTLLYMSKLTLVLSCAMKFESYPHDTQICSMMIESLSHTTQDLVFIWNMTDPLVVNPDIELPQLDISNNYTTDCTIEYSTGNFTCIQIVFNLRRRLGYHLFHTYIPSALIVVMSWIAFWIKPEAIPARVTLGVTSLLTLATQNTQSQQSLPPVSYVKAIDIWMSSCSVFVFLSLMEFAVVNNYMGPVATKAMKGYSDEDLRESIDEFKTPMRPESRNRSPVRPLSVQYDTCCHGRATAILIDKFSRFFFPFSFAILNVVYWSTFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MYB2</accession>
    <name>A0A8J2MYB2_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chemosensory protein 15.3769</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS12687</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5107314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MYB2"/>
    <dbReference type="OrthoDB" id="6355718at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.2080.10">
        <property type="entry name" value="Insect odorant-binding protein A10/Ejaculatory bulb-specific protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005055">
        <property type="entry name" value="A10/PebIII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036682">
        <property type="entry name" value="OS_D_A10/PebIII_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03392">
        <property type="entry name" value="OS-D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100910">
        <property type="entry name" value="Chemosensory protein Csp2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035195807" evidence="1">
        <location>
            <begin position="21"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5107314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="119" mass="13337" checksum="A6B5CE7B31ACC036" modified="2022-05-25" version="1">MKTQIICLCVLGVIALVSCAQHVPFSKLQEITPEQITLVESQMPCVLQTPGASCSKIGLRAKDVLPEFLKTKKCSTCTPEEKEKIDQIFTILHTTELKKYLIPLQNLYGNNQTYDHNSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MZ13</accession>
    <name>A0A8J2MZ13_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Similar to byn: T-related protein (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HICCMSTLAB_LOCUS13581</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5108945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MZ13"/>
    <dbReference type="OrthoDB" id="7442607at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001708">
        <property type="term" value="P:cell fate specification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003007">
        <property type="term" value="P:heart morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001707">
        <property type="term" value="P:mesoderm formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20192">
        <property type="entry name" value="T-box_TBXT_TBX19-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.820:FF:000002">
        <property type="entry name" value="T-box transcription factor Brachyury"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.820">
        <property type="entry name" value="Transcription factor, T-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008967">
        <property type="entry name" value="p53-like_TF_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046360">
        <property type="entry name" value="T-box_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036960">
        <property type="entry name" value="T-box_sf"/>
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        <property type="entry name" value="TF_T-box"/>
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        <property type="entry name" value="TF_T-box_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11267">
        <property type="entry name" value="T-BOX PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11267:SF106">
        <property type="entry name" value="T-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00907">
        <property type="entry name" value="T-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00938">
        <property type="entry name" value="BRACHYURY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00937">
        <property type="entry name" value="TBOX"/>
    </dbReference>
    <dbReference type="SMART" id="SM00425">
        <property type="entry name" value="TBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49417">
        <property type="entry name" value="p53-like transcription factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01283">
        <property type="entry name" value="TBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01264">
        <property type="entry name" value="TBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50252">
        <property type="entry name" value="TBOX_3"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="4 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="T-box" evidence="9">
        <location>
            <begin position="47"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="286"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="357"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="415"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="505"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="22"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="434"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="445"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="505"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="525"/>
            <end position="543"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAG5108945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="543" mass="60614" checksum="4574110DBC3349CE" modified="2022-05-25" version="1">MQSTTTLDLEGSTGRSSGCCGDGDHRGTEDDDDRSERARSCQLSLSLEDRELWTRFQTITNEMIVTKNGRRMFPVVKVVARGLEPAAMYTLLLEFVQIDPHRWKYVNGEWVPGGKAEVAPPNPIYIHPESPNFGAHWMKEAISFAKVKLTNKSNGNGQIMLNSLHKYEPRVHLVRVGAEEQRTVLTYRFPETQFIAVTAYQNEEVTGLKIKYNPFAKAFLDAKERPTDQQTYPQYTSAWFLPQPAMTYEYAPPSAIAMTQSQVSNSSCNLSNTCTVSPGSHKTYVTSNWSPRSPEPLPALNSSLPQEWPASPLPSPTSSSPVPYTHLSPLGRPGNSSTVPTTCTFYIPQACNTTHEHESSNWLHPGMSDQVTQQQQQQQSYLNLNLHLHHQLPTYSPRGTTLQVLQQANDITQHSTGQEHAYDHQGYHQSPDQTHPDQTHLLELHSQSEPTSAISGDQYDPKTHNQNHSHNHDLTGYQDNQDNDSRVSEARRYVTSVIDHRHSVVSPAAASATAVSNQRDPGDGDNQTWTPLTPSPVTQNSSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-24" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>B9W4K4</accession>
    <name>B9W4K4_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cc_pif6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">Cc50C22.3</name>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS5447</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2009" name="Science" volume="323" first="926" last="930">
            <title>Polydnaviruses of Braconid Wasps Derive from an Ancestral Nudivirus.</title>
            <authorList>
                <person name="Bezier A."/>
                <person name="Annaheim M."/>
                <person name="Herbiniere J."/>
                <person name="Wetterwald C."/>
                <person name="Gyapay G."/>
                <person name="Bernard-Samain S."/>
                <person name="Wincker P."/>
                <person name="Roditi I."/>
                <person name="Heller M."/>
                <person name="Belgahzi M."/>
                <person name="Pfister-Wilhem R."/>
                <person name="Periquet G."/>
                <person name="Dupuy C."/>
                <person name="Huguet E."/>
                <person name="Volkoff A.N."/>
                <person name="Lanzrein B."/>
                <person name="Drezen J.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5089978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="CAR82241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="7660248at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5089978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAR82241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="143" mass="17061" checksum="BB900DCF200C2D1D" modified="2009-03-24" version="1">MRLSHEYFMSVLSDPIFLNRVKIHANDDFKTRSIQVTNEEACKYFWMKVWMDILIPAYRKLEFYREVEDNNLKVHVNALDYPEYNYVSLLGVPPTWTQLHYVSTIAQSKERPFLKPIFNSLGVYIAYLVVAIIISFHYILKKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-10-16" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>S6CVT1</accession>
    <name>S6CVT1_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cc_bv4.2_16.5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">bv4-2</name>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS6234</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Philos. Trans. R. Soc. Lond., B, Biol. Sci." volume="368" first="20130047" last="20130047">
            <title>Functional endogenous viral elements in the genome of the parasitoid wasp Cotesia congregata: insights into the evolutionary dynamics of bracoviruses.</title>
            <authorList>
                <person name="Bezier A."/>
                <person name="Louis F."/>
                <person name="Jancek S."/>
                <person name="Periquet G."/>
                <person name="Theze J."/>
                <person name="Gyapay G."/>
                <person name="Musset K."/>
                <person name="Lesobre J."/>
                <person name="Lenoble P."/>
                <person name="Dupuy C."/>
                <person name="Gundersen-Rindal D."/>
                <person name="Herniou E.A.Drezen.J.M."/>
            </authorList>
            <dbReference type="PubMed" id="23938757"/>
            <dbReference type="DOI" id="10.1098/rstb.2013.0047"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
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        <property type="protein sequence ID" value="CAG5092574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="protein sequence ID" value="CCQ71286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="7677094at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="47"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5092574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCQ71286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="270" mass="30863" checksum="12BAA7364455CBFA" modified="2013-10-16" version="1">MNRQSNNFIPVIDIASSSYDFFRSSQLPEERLNRSVVELLLHLDETRLEGSEPGHQDNSSSLESEDNEPDSNFTTALQASWSTAAPIRFFSFADQVEAAIVHSPVVQGPEVQPNNFHNWLISTVILDDLSYREPFMNSARDANQLTDQDLFLRGLSLYENADLMGPRELVDLPFLPCAMRTGDTLLDIPFVDPLLIVIWCLHIEDVHWMLNVLPWRVVDRPIRTGRSILAWIIGIPSVHEFLEETRAPLSIVFKLIHFLDMYHESLNHQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-10-16" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>S6D316</accession>
    <name>S6D316_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cc_ptp.m_1.8</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">Protein tyrosine phosphatase PTPM</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">ptpm</name>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS7317</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Philos. Trans. R. Soc. Lond., B, Biol. Sci." volume="368" first="20130047" last="20130047">
            <title>Functional endogenous viral elements in the genome of the parasitoid wasp Cotesia congregata: insights into the evolutionary dynamics of bracoviruses.</title>
            <authorList>
                <person name="Bezier A."/>
                <person name="Louis F."/>
                <person name="Jancek S."/>
                <person name="Periquet G."/>
                <person name="Theze J."/>
                <person name="Gyapay G."/>
                <person name="Musset K."/>
                <person name="Lesobre J."/>
                <person name="Lenoble P."/>
                <person name="Dupuy C."/>
                <person name="Gundersen-Rindal D."/>
                <person name="Herniou E.A.Drezen.J.M."/>
            </authorList>
            <dbReference type="PubMed" id="23938757"/>
            <dbReference type="DOI" id="10.1098/rstb.2013.0047"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5093991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="HF586476">
        <property type="protein sequence ID" value="CCQ71321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S6D316"/>
    <dbReference type="OrthoDB" id="8609993at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009653">
        <property type="term" value="P:anatomical structure morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048666">
        <property type="term" value="P:neuron development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00047">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050348">
        <property type="entry name" value="Protein-Tyr_Phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000242">
        <property type="entry name" value="PTP_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19134:SF534">
        <property type="entry name" value="LD27988P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19134">
        <property type="entry name" value="RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00102">
        <property type="entry name" value="Y_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00700">
        <property type="entry name" value="PRTYPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00194">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50055">
        <property type="entry name" value="TYR_PHOSPHATASE_PTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="1">
        <location>
            <begin position="27"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="2">
        <location>
            <begin position="200"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5093991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCQ71321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="295" mass="34499" checksum="D5A55D3369512E2B" modified="2013-10-16" version="1">MNTDLFAPFQNFEFLARSTHPKYTDVIADEYSRICQEPLNGTYENWKKPKNKNKNLFRNIPCWDNSRVVLHQTNDGADYINGNYVSGFELKRKFIATEQPMASTLGNFWTMIWEENTRVIVMLNGSEEEAQQSYPYLSSSQTDIISGDFKIKQKERNEEKDYTETVLIITHLNSGQSKRVSHFKYLHWPEHTFPHEEDILKFLEIINNRNAEFFIEAEEYHQRMPGAIVVHGNAGIRRTTAFCAIDSCLYEAVVKKTVSIPSVVLRIRQQRNFSFPGLSYYTYVHSVLLHFLVHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-10-16" modified="2023-09-13" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>S6D9K0</accession>
    <name>S6D9K0_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Cc_bv21.1_29.22</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">bv21-1</name>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS6139</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2013" name="Philos. Trans. R. Soc. Lond., B, Biol. Sci." volume="368" first="20130047" last="20130047">
            <title>Functional endogenous viral elements in the genome of the parasitoid wasp Cotesia congregata: insights into the evolutionary dynamics of bracoviruses.</title>
            <authorList>
                <person name="Bezier A."/>
                <person name="Louis F."/>
                <person name="Jancek S."/>
                <person name="Periquet G."/>
                <person name="Theze J."/>
                <person name="Gyapay G."/>
                <person name="Musset K."/>
                <person name="Lesobre J."/>
                <person name="Lenoble P."/>
                <person name="Dupuy C."/>
                <person name="Gundersen-Rindal D."/>
                <person name="Herniou E.A.Drezen.J.M."/>
            </authorList>
            <dbReference type="PubMed" id="23938757"/>
            <dbReference type="DOI" id="10.1098/rstb.2013.0047"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5092438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="HF586473">
        <property type="protein sequence ID" value="CCQ71191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S6D9K0"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5092438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCQ71191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="110" mass="12861" checksum="00931E6EC1A6FE95" modified="2013-10-16" version="1">MVIQWLHRKVPVFYLAIDIRCYCKPFTEALIDSMQYSNKSSMKRNRAKKRFWHAIIESGQFQSRSLFYGLAAKSIVPCLVTEKVSGQLRPVFKKAAEAFQKYVAEHTREN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-10-16" modified="2023-09-13" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>S6D9K2</accession>
    <name>S6D9K2_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cc_ep1.6_28.1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">ep1-like6</name>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS5843</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Philos. Trans. R. Soc. Lond., B, Biol. Sci." volume="368" first="20130047" last="20130047">
            <title>Functional endogenous viral elements in the genome of the parasitoid wasp Cotesia congregata: insights into the evolutionary dynamics of bracoviruses.</title>
            <authorList>
                <person name="Bezier A."/>
                <person name="Louis F."/>
                <person name="Jancek S."/>
                <person name="Periquet G."/>
                <person name="Theze J."/>
                <person name="Gyapay G."/>
                <person name="Musset K."/>
                <person name="Lesobre J."/>
                <person name="Lenoble P."/>
                <person name="Dupuy C."/>
                <person name="Gundersen-Rindal D."/>
                <person name="Herniou E.A.Drezen.J.M."/>
            </authorList>
            <dbReference type="PubMed" id="23938757"/>
            <dbReference type="DOI" id="10.1098/rstb.2013.0047"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5092002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="HF586473">
        <property type="protein sequence ID" value="CCQ71203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S6D9K2"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036441357" evidence="1">
        <location>
            <begin position="22"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5092002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCQ71203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="285" mass="32706" checksum="DD0F06ACDB568E66" modified="2013-10-16" version="1">MFEKLLVVVLVMHMAPSLIQAKLVQMVIPTEPPPPPPTLRYYIAYQRCPRVHSAKGYLLPYIQIDRLQNPCMFSGESITITDSIINVTNTDLHLVSKNITLIGNLFDGHNQVIRIFADNMKLHNNQFVGQNRTYEAVGVNIYLSHNSHKGHTSTFKVTAPYIKEVTNMHVGNDQYHNLTGVALSEIRNEYPEKLWLYQRAGLVIANTGNVHYQKEFSIERDTCMYTGYNQNHNLYATNVKEHKNFFTGENQIHRETGKNVTTTMNWYVGDKIHTINGVDKPDDTW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2E4J1</accession>
    <name>A0A8J2E4J1_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to SDR-1: Farnesol dehydrogenase (Aedes aegypti)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS202</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001037">
        <property type="protein sequence ID" value="CAG5072980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2E4J1"/>
    <dbReference type="OrthoDB" id="1933717at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43115">
        <property type="entry name" value="DEHYDROGENASE/REDUCTASE SDR FAMILY MEMBER 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43115:SF4">
        <property type="entry name" value="DEHYDROGENASE_REDUCTASE SDR FAMILY MEMBER 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5072980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="103" mass="11042" checksum="640E7383AECD40A6" modified="2022-05-25" version="1">MKGLSDSVGSNSYNLYPACKHASVAITHSVRRELSQAKIAIKITSISPGLVKTNIASKTNLKNLFDEIPALEPEDVADAVLYALGTPPHVQISELTIQRTGEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2E7H5</accession>
    <name>A0A8J2E7H5_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Similar to Cnnm2: Metal transporter CNNM2 (Mus musculus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HICCMSTLAB_LOCUS1972</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001116">
        <property type="protein sequence ID" value="CAG5075991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2E7H5"/>
    <dbReference type="OrthoDB" id="5353557at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010960">
        <property type="term" value="P:magnesium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="entry name" value="CBS-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045095">
        <property type="entry name" value="ACDP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002550">
        <property type="entry name" value="CNNM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12064">
        <property type="entry name" value="METAL TRANSPORTER CNNM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12064:SF94">
        <property type="entry name" value="UNEXTENDED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25562">
        <property type="entry name" value="CNBH_CNNM2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01595">
        <property type="entry name" value="CNNM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="cAMP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51846">
        <property type="entry name" value="CNNM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="1 3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1 3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035204392" evidence="4">
        <location>
            <begin position="29"/>
            <end position="945"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="337"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="395"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="422"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="452"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="domain" description="CNNM transmembrane" evidence="6">
        <location>
            <begin position="333"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="5">
        <location>
            <begin position="662"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="822"/>
            <end position="945"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="855"/>
            <end position="871"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="872"/>
            <end position="893"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAG5075991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="945" mass="106377" checksum="6E1A1750B527077D" modified="2022-05-25" version="1">MMAQHVGRSRKSPAFLLIILFIINSTTIIDSSALPRINGDNTKPVINSVKLITSDYYHDILVNNKSNSNTIIKSDSYSYSSSVVAGNGESDQDAGDKYYLLTTGVNLNKLKHIKWTPDKTYCDININNNSGNINNYGINIWSNSEGTSAIFQFYNILEVTRIYLCQLDTNFQGDELLQRKWRPVEDLLVHLSRRKRDLPSVGQPLIPANGDAEKLHIYGLRLEGEQEEQEFANGVPKVVGETLVTIRIFGSGITTDTVISFTDIPQNRGEICDKIKSQEFIVEKVDNFTAIISGMLPLGSPFYICAKSMSSGSVNLFYHQGTEVYKQIISYQKTLPLWLQIIVILTCLSFSALFSGLNLGLMSMDRTELKILCNTGTEKEREYARTIQPVRNYGNYLLCSILFSNVLVNSIFTILLDDLTSGTVTVIGATLAIVIFGEISPQAFCSRHGLCVGAKTILITKITMVITYPLSYPISKFLDYMLGEEIGNVYNRERLKELVKVTTGYNDLEKDEYDLKLYFMFSFVKDVVNTRKVLHKFNYIHVVYKITYNYLSGHKGHMAFVQRVNNEGEGDPFYEVIGLITLEDVIEELIQAEIMDETDVFTDNRSKRKRLNNRPKLPDFTVFAEKKESQRIHISPQLTLAMFQYLSTTVAPFKPDTISETILRRLLKQDIIHHIKVKSREKARNDPAALIYQQGKSVDYFVLILEGRVEVTVGKENLTFESGPFTYFGCQALGTNIGVVESPTTNVNPQALGSIQSINLDAILRHTFVPDYSVRAVTEVFYLKVKRSLYLAAKRATLLERSQKDPSPSNDQFDDEVEKLLHSLDEDDRSMQSSPILSRKDDDMKSPEQNSPIRSATAPTSPTPVSASPVTNSKFLPQSKTSEPNGQLRNSPNKIEEPVEPSTNNSESHSKLNLDAEIASRLLSKKTNEDNNDELTNLLSTQDRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2E8Z1</accession>
    <name>A0A8J2E8Z1_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="14">ATP-binding cassette transporter subfamily G member 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">HICCMSTLAB_LOCUS548</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001114">
        <property type="protein sequence ID" value="CAG5073662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2E8Z1"/>
    <dbReference type="OrthoDB" id="66620at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033344">
        <property type="term" value="P:cholesterol efflux"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd03213">
        <property type="entry name" value="ABCG_EPDR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000267">
        <property type="entry name" value="ATP-binding cassette, sub-family G (WHITE), member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050352">
        <property type="entry name" value="ABCG_transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48041:SF78">
        <property type="entry name" value="ABC TRANSPORTER EXPRESSED IN TRACHEA, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48041">
        <property type="entry name" value="ABC TRANSPORTER G FAMILY MEMBER 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-1278">Translocase</keyword>
    <keyword evidence="6 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="495"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="524"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="565"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="603"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="633"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="663"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="712"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="13">
        <location>
            <begin position="116"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CAG5073662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="744" mass="82106" checksum="C77D5830175D2A38" modified="2022-05-25" version="1">MDDIKNLTIGSVPRYNGDEQVQFIAEGSNQVTIRSPPPSLHLENLNNAVLGGSQNNLHCSCNGTNQAPVNGNAGTGCTSGGLARKIQNHTGVSPGQVNKRPAVSLTHLPKRPAVDIEFKNLAYSVSEGRQRGYKTILKCVNGKFRSSELTAIMGPSGAGKSTLMNVLAGYKTSNLNGSILINGKDRNLRRFRKMSCYIMQDDRLLPHLTVHEAMMVSANLKLGKDLDASAKKVVVEEIIDTLGLNDASNTHTQCLSGGQRKRLSIALELVNNPPVMFFDEPTSGLDSSSCFQCLSLLKSLSRGGRTIICTIHQPSARLFEMFDNLYLLAEGQCIYQGNVGGLVPFLSSMGLECPSYHNPADYVMEVACGEHGECVEKLVTAVNNGKCNNYQHHQSTFTTTMVANDIAKQSPPTVQTKAEEAATGNSLIPNGIPKGPGGATALNMPVSCTTSLLDSAESIEQKVGFPTNGWTQFWILLKRTFLSQMRDMTLTRVRLISHIIVGLLIGALYYDIGNEGGEAYSNAGCIFFTVMFLMFTAMMPTILTFPTEMAVFVREHLNYWYSLKAFYLARTVSDLPFQTVFSIVYVMIVYFMTSQPLETYRFLMYLNICILTSFVSQSIGLLIGAAMSVESGMFIGPVSSVPIVLFSGFFIKFSAMPNYLSWLSYVSYIRYGFEGAMITVFGYNRPRLKCSIEYCHFRSPTKFLEEMAMLDAVYWIDVVALIGFLLLLRISTYFVLRLKLRSLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2EBS3</accession>
    <name>A0A8J2EBS3_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 15">Alpha-amylase</fullName>
            <ecNumber evidence="6 15">3.2.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">HICCMSTLAB_LOCUS687</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 15">
            <text>Endohydrolysis of (1-&gt;4)-alpha-D-glucosidic linkages in polysaccharides containing three or more (1-&gt;4)-alpha-linked D-glucose units.</text>
            <dbReference type="EC" id="3.2.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>chloride</name>
            <dbReference type="ChEBI" id="CHEBI:17996"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="5">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the glycosyl hydrolase 13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.1" evidence="6 15"/>
    <dbReference type="EMBL" id="CAJNRD030001114">
        <property type="protein sequence ID" value="CAG5073915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2EBS3"/>
    <dbReference type="OrthoDB" id="550577at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004556">
        <property type="term" value="F:alpha-amylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11317">
        <property type="entry name" value="AmyAc_bac_euk_AmyA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006048">
        <property type="entry name" value="A-amylase/branching_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031319">
        <property type="entry name" value="A-amylase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006046">
        <property type="entry name" value="Alpha_amylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="GH13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43447">
        <property type="entry name" value="ALPHA-AMYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02806">
        <property type="entry name" value="Alpha-amylase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00110">
        <property type="entry name" value="ALPHAAMYLASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00632">
        <property type="entry name" value="Aamy_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0106">Calcium</keyword>
    <keyword evidence="12 15" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="11" id="KW-0868">Chloride</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="13 15" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="8 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="16" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035282689" description="Alpha-amylase" evidence="16">
        <location>
            <begin position="18"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 13 catalytic" evidence="18">
        <location>
            <begin position="28"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-amylase C-terminal" evidence="17">
        <location>
            <begin position="407"/>
            <end position="495"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU003615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU361134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM00632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="CAG5073915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="500" mass="55919" checksum="00244DB8C4124819" modified="2022-05-25" version="1">MFSWVLRIFLLGYVVWAQKDPHYKDDRDTMVHLFEWKFDDIADECERFLGPMGYGGVQVSPINENLIMRNRPWYERYQPLSFKINTRSGNESSFASMVKRCNAVDVRIYVDIVVNHMSGDANPAVGTGGSTANTSSRSYPAVPFSFADFHQPVCSISNYNNATEVRNCELSGLHDLDQSKEYVRSKIVEFINRIIDLGVAGIRVDAAKHMWPQDLKVIYSRLNNLSVAHGFPAKSRLFIYQEVIDLGGEAIKKGEYTSLGRVIEFTFGIVLGNFFRGNEQLKFLKNWGNGWGLLPSEDALVMIDNHDNQRGHGAGGATILTYKLPKQYKMATAFELAHPYGTTRVMSSFNFTDPSIGPPADKNGSILSPEIDPKTGTCKNGWICEHRWHQIQQMVVFRLVAKNDPINNWWDNDGDQIAFSRGSNAFIALNNDDEDLKQSLVTGLPAGKYCDVITGQVKNNKCTGKTVEVGKNGVAFVDIPASAEDGVLAIHIGRQSKVRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2ECN5</accession>
    <name>A0A8J2ECN5_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Similar to glra1: Glycine receptor subunit alphaZ1 (Danio rerio)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">HICCMSTLAB_LOCUS1126</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the ligand-gated ion channel (TC 1.A.9) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001116">
        <property type="protein sequence ID" value="CAG5074915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2ECN5"/>
    <dbReference type="OrthoDB" id="8175758at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005254">
        <property type="term" value="F:chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004890">
        <property type="term" value="F:GABA-A receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099095">
        <property type="term" value="F:ligand-gated monoatomic anion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022824">
        <property type="term" value="F:transmitter-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd18987">
        <property type="entry name" value="LGIC_ECD_anion"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19049">
        <property type="entry name" value="LGIC_TM_anion"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.390:FF:000032">
        <property type="entry name" value="gamma-aminobutyric acid receptor subunit epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.390">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006028">
        <property type="entry name" value="GABAA/Glycine_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006202">
        <property type="entry name" value="Neur_chan_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036719">
        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038050">
        <property type="entry name" value="Neuro_actylchol_rec"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006029">
        <property type="entry name" value="Neurotrans-gated_channel_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018000">
        <property type="entry name" value="Neurotransmitter_ion_chnl_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18945">
        <property type="entry name" value="NEUROTRANSMITTER GATED ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02931">
        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02932">
        <property type="entry name" value="Neur_chan_memb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00253">
        <property type="entry name" value="GABAARECEPTR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00252">
        <property type="entry name" value="NRIONCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90112">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane pore"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00236">
        <property type="entry name" value="NEUROTR_ION_CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10 11" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8 11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-0675">Receptor</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0732">Signal</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035336887" evidence="11">
        <location>
            <begin position="18"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="245"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="270"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="302"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="394"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel ligand-binding" evidence="12">
        <location>
            <begin position="34"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel transmembrane" evidence="13">
        <location>
            <begin position="245"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CAG5074915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="421" mass="49143" checksum="433C166DC22130F5" modified="2022-05-25" version="1">MRFTVIFLLLRIGFVYGLYKTKNKTVGPEVVLPSTYIKEIRPSLEEGKPVEVDFKIFVVDINSINVEDMDFRVDLFIRLSWTETRLRMSEEIFEIGDDYVTLPPEFFDKLWQPDPYFLNSKIAEIATLTHKFSSVTLYRNKTVTYSARMHAIVACQMEFQLYPMDIQICPIYIEISYNSQKLQLKWASTGVTVNPELKLLQYNFGEPQLLQEIHSYVTEKLGNYSRLIVFFRFERQIGHHLIQTFAPSTLVVMLSWFSFWLGLDAIPGRVTLLVTSMLTLVTMFTGLKSDIPPVAYVKALDLWMAGCMVFVFASLSEFVVVKVIDARQKQLELQLNNLRAYRASVERSVSIWDYEASLDLEPKRKRGSADLLQPTWLDLELLRPQRTLSKKIDYYSRLIFPSLFLLFTVLYWPIVIFKKRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2EI23</accession>
    <name>A0A8J2EI23_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS456</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001114">
        <property type="protein sequence ID" value="CAG5073513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2EI23"/>
    <dbReference type="OrthoDB" id="504708at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5073513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="85" mass="9288" checksum="F3D7756FB79A63C8" modified="2022-05-25" version="1">MAISSCSDDVECGEPWHGECSSGKKCSCKENNVAINVSTCYPLLNGLCWCDEQCVTKNSICLDYHCLCETGYIPVANNLCDRANL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2EJK4</accession>
    <name>A0A8J2EJK4_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Similar to DPP9: Dipeptidyl peptidase 9 (Homo sapiens)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HICCMSTLAB_LOCUS1217</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S9B family. DPPIV subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001116">
        <property type="protein sequence ID" value="CAG5075023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2EJK4"/>
    <dbReference type="OrthoDB" id="16520at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008239">
        <property type="term" value="F:dipeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.140.10.30">
        <property type="entry name" value="Dipeptidylpeptidase IV, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045785">
        <property type="entry name" value="Dpp_8/9_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001375">
        <property type="entry name" value="Peptidase_S9_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002469">
        <property type="entry name" value="Peptidase_S9B_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050278">
        <property type="entry name" value="Serine_Prot_S9B/DPPIV"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11731:SF193">
        <property type="entry name" value="DIPEPTIDYL PEPTIDASE 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11731">
        <property type="entry name" value="PROTEASE FAMILY S9B,C DIPEPTIDYL-PEPTIDASE IV-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19520">
        <property type="entry name" value="Dpp_8_9_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00930">
        <property type="entry name" value="DPPIV_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00326">
        <property type="entry name" value="Peptidase_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0720">Serine protease</keyword>
    <feature type="domain" description="Dipeptidyl peptidase 8 /9 ,N-terminal" evidence="8">
        <location>
            <begin position="10"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="Dipeptidylpeptidase IV N-terminal" evidence="7">
        <location>
            <begin position="174"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S9 prolyl oligopeptidase catalytic" evidence="6">
        <location>
            <begin position="621"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF19520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAG5075023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="822" mass="93967" checksum="F22C5D579688FAF0" modified="2022-05-25" version="1">MESCKEGKDFEYEPSPKNKKSWSELRGVVSEFRRKLSGVSDGSVPDHITFRSLPDGRTRIYFLGTPSNGWETTLLFVDIGQYEQCNGCKLHWQPVIEANFQSVSSANRLSKEEQLLWERKRLTTWGITSYEIHLETGKLVFPAASSLYQCIDTGFLPGPLFPSELRILAPGAKLCPQICPWNSALVAHTCSGDLYLSHSITGCSVRLTYARKGGKNLTEDPLTAGTPSYVMQEEFTRYTGYWWQPKSSDGVYRIVYEEVDESDVKIFCFPSSTLNSGEVDEFRFPRAGTSNAKSNLKMLQFRLTDTQQIVEIETLELQYPLHIMFPWMEYLVRVGWTPDGSNVWVQLLDRRQQRIELVLLSVDNFCEPPPNVYNSENHFTPSSASVQVIYSEESSIWINVNDLLYFLPSDDPTEVKFIWGSEESKYMHLYLITSSIAGLSNGIEEPLDRLDSVYFQPRVISKVAITQGDWPVLGKKIWVDTTNSIVYFVGLKEGPLEQHAYAVSLRRPLEVRLLTRPGHSYNSICFNKECTMMVAVYSSIKTLPTCQVFRISQSDWTVESISLTPVGYLLEPTNSEIDLLAPVIHAHKINSGDTIYSMVFKPHNYRPRVKYPVILQGMRHLRMHMLASQGYCVVLIDNRGSHYRGLMFESHLKRRMGTVELSDQVEVLNLLADKLGYLDLNRVALHGWSYGGYLSLMGLIQYPEVFKVAIAGAPVTCWNLYDTGYTERYMDHPDSNYHGYINSSVLTYVNKFPDEENRLLIIHGLIDENVHFFHTSELINALIKTGKPYQLQIYPTERHSLRSLDATRHYETTLLSFLQNHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2GZC4</accession>
    <name>A0A8J2GZC4_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Methionine--tRNA ligase, cytoplasmic</fullName>
            <ecNumber evidence="3">6.1.1.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Methionyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">HICCMSTLAB_LOCUS328</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>tRNA(Met) + L-methionine + ATP = L-methionyl-tRNA(Met) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:13481"/>
            <dbReference type="Rhea" id="RHEA-COMP:9667"/>
            <dbReference type="Rhea" id="RHEA-COMP:9698"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78530"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.10"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.10" evidence="3"/>
    <dbReference type="EMBL" id="CAJNRD030001114">
        <property type="protein sequence ID" value="CAG5073385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2GZC4"/>
    <dbReference type="OrthoDB" id="5844513at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017101">
        <property type="term" value="C:aminoacyl-tRNA synthetase multienzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004825">
        <property type="term" value="F:methionine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006431">
        <property type="term" value="P:methionyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07957">
        <property type="entry name" value="Anticodon_Ia_Met"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.28.20:FF:000001">
        <property type="entry name" value="Methionine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.730.10">
        <property type="entry name" value="Isoleucyl-tRNA Synthetase, Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.20">
        <property type="entry name" value="Methionyl-tRNA synthetase, Zn-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041872">
        <property type="entry name" value="Anticodon_Met"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023458">
        <property type="entry name" value="Met-tRNA_ligase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015413">
        <property type="entry name" value="Methionyl/Leucyl_tRNA_Synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033911">
        <property type="entry name" value="MetRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029038">
        <property type="entry name" value="MetRS_Zn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45765">
        <property type="entry name" value="METHIONINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45765:SF1">
        <property type="entry name" value="METHIONINE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19303">
        <property type="entry name" value="Anticodon_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09334">
        <property type="entry name" value="tRNA-synt_1g"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01041">
        <property type="entry name" value="TRNASYNTHMET"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57770">
        <property type="entry name" value="Methionyl-tRNA synthetase (MetRS), Zn-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 13" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="8 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 13" id="KW-0436">Ligase</keyword>
    <keyword evidence="7 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 13" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methionyl/Leucyl tRNA synthetase" evidence="15">
        <location>
            <begin position="59"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="Methionyl/Leucyl tRNA synthetase" evidence="15">
        <location>
            <begin position="455"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="domain" description="Methionyl-tRNA synthetase anticodon-binding" evidence="16">
        <location>
            <begin position="655"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="796"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="796"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="806"/>
            <end position="816"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU363039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF09334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF19303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CAG5073385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="832" mass="96512" checksum="E477512A0D6AE9D5" modified="2022-05-25" version="1">MENSKLTNVPQENNLKEKEEELITEEELQAVKSSWLNKTQLTSKKLEYPVLPKKGERNILITSALPYVNNVPHLGNIIGCVLSADIFARFCRQKNYNTLYVSGTDEYGTATEAKAFEEKMTCQEICDKYFTIHDEVYRWFNIAFDRFGRTSTKEQTEVVQQFFLRVKEQGYIFTDTVDQLRCEGCEKFLADRFVEGICPDCKYEDARGDQCDGCGHLINATELINPRCKLCNQTPVVKTSEHFFLDLPKKIKTFYNRINRMSLGVARNTPAYIIRQQVGIEHMEYIIKERALRFLADVVRMDDDRWTKICIKNEMREIMNKNPKKWGKTIEKFLQKIGIGELPKMIYKGCSSDDVEEKIKSGLENYKWMLDEKEEILIKKSTYNELYKNIKTEESNNYWKRDNIRSEDKETWARLRCGNIWRDGKKGQNNWGCRICEKEQETIIHIINCKEIHEKVTVEGKEAKNKWLEEPRCITRDIKWGIPVPLEGYEDKVFYVWFDAPLGYLSISKNYHEDYEQWWRPQPEMDVSLYQFMAKDNVPFHAIMFPASLLAANQGHVLVKSIMAVEYLNYEDTKFSKSRGVGVFGTDAKETGIPADVWRFYLAYVRPEGQDTNFNWTDLATKTNSELLNNFGNFVNRSLAFAEKNYEGIIQEMELRDEEYNLLACVQRELTQYNLLMEQAKLRDSLKLILSISKLGNQYLQAQQPWAKIKGDDNDKKIAGMVSGICCNLSCLLSSLIGPFMPAISLSLRAQLGFEDHYGFIPDTVTILLEPGHKIGKSSPLFARITDKEIQALREKFGGVKEEKPKKNKKTQKQSKKNKDEVADLQKSIASL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H0K5</accession>
    <name>A0A8J2H0K5_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS2249</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001117">
        <property type="protein sequence ID" value="CAG5076679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H0K5"/>
    <dbReference type="OrthoDB" id="10500494at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5076679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="270" mass="31882" checksum="461FC2B9C311DB8D" modified="2022-05-25" version="1">MEELLNSMLESTDNKPAVFNLKAMSNPEDHQMVSEPHQSVEELMAKYGMHRECRCDKFNEMVKLLDQEIQRFDEKSRAFWLRHPNCHSTDKSKLIELMINDLGKFDNKVTQPEDNHCWNSPILYQSIIDHQSLNNYLDYLDNNTEENELVDLFSVARSRKPKKKKKKKMASKPRQSLEEFMAENGIKPTCNCAKCRVMIKLLNEKIERFNEKSRAYNYRHHYRDVVNIPNLLERLKHDEGKFENNVTKPGDNPYLNTPHIYDSLSKVFVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H2Q9</accession>
    <name>A0A8J2H2Q9_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS1583</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001116">
        <property type="protein sequence ID" value="CAG5075429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H2Q9"/>
    <dbReference type="OrthoDB" id="7989680at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5075429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="205" mass="24629" checksum="14B96B05E8A3150F" modified="2022-05-25" version="1">MRPILSYAAPIWWNTGASIMEKYRKLERSCLRSCLGLYKTAESDYKKCVDNKTLYNSASIPRFDIFILRLTRRYYSTLNQIDNIYLKNLKCLDWFQVQRMAKSKYSAPEIFTNLDKLGFIQNENNIPTIFHVKRRCTNKAIPLDENIHRNNLVYSTAISDADKNCLDRLSENYWWLQEDAKFIDELRRRARLKQQQQQRRQRRAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H447</accession>
    <name>A0A8J2H447_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Similar to Slc6a5: Sodium- and chloride-dependent glycine transporter 2 (Mus musculus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HICCMSTLAB_LOCUS2116</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001116">
        <property type="protein sequence ID" value="CAG5076135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H447"/>
    <dbReference type="OrthoDB" id="6581954at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005283">
        <property type="term" value="F:amino acid:sodium symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015187">
        <property type="term" value="F:glycine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0089718">
        <property type="term" value="P:amino acid import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000175">
        <property type="entry name" value="Na/ntran_symport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037272">
        <property type="entry name" value="SNS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11616">
        <property type="entry name" value="SODIUM/CHLORIDE DEPENDENT TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11616:SF236">
        <property type="entry name" value="TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00209">
        <property type="entry name" value="SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00176">
        <property type="entry name" value="NANEUSMPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161070">
        <property type="entry name" value="SNF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50267">
        <property type="entry name" value="NA_NEUROTRAN_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0915">Sodium</keyword>
    <keyword evidence="5" id="KW-0769">Symport</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="39"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="67"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="111"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="244"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="273"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="326"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="354"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="414"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="455"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="485"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="45"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="52"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="329"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="361"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="426"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="430"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="151"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR600175-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR600175-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAG5076135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="521" mass="58490" checksum="4670A3FAA91DDF62" modified="2022-05-25" version="1">MTLDRIESPKAKKKLSLGVGGAFVELPAERTGWANKTEFILSCIGYAIGIGNVWRFPFFVYRNGRGAFLIAFILMLITMGLPIFFMELCIGQYTGVGPMEAYRRMSPAFGGLGICTLVVIGLVTVYYMVIIAWTLFYTFASFSSKLAWAYCDNGFNTENCYSGLEDKQCQDTNSTTIFFNKTCQLITKVCYNFGYDKGNKSYCFNETHQKPIRKLYDSVLSSEEYFSDYVLGIRGATWDNWGGIRWELLGCLTLAWIICYLCLIRGVQSVGKIVYFTALFPYFVLIALLIRGLTLDGAEYGIKWFITPVWPTLFDAKVWGDAASQIFYSLGIGCGSLITISSFSTFSNNCHRDAIFITFTNLFTSIFAGIVIFSIMGYLAKQMDLPLEDVVKSGPALAFIAYPEAVVRMPLSNLWAILFFFMLFILGLGSQFAGVQAINTAILDVRPSLRKHESLVILVICVCGWILALPMIFDGGVYLNTLMDWNTASWAILLIGLLEVARNWNLFRLTETWGPSKKTSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H4Z1</accession>
    <name>A0A8J2H4Z1_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS419</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001114">
        <property type="protein sequence ID" value="CAG5073476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H4Z1"/>
    <dbReference type="OrthoDB" id="7666678at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="288"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5073476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="425" mass="49755" checksum="BDEF84C0259E2147" modified="2022-05-25" version="1">MDPWVPSKGKSCSNGIYRLCKKSFKELCLGDAVGETKYTNDNFLDFVDVYCQEKFSPLLYSTNDLKTEEFDQFSQNGKQEIIHDQCNSNLNFISEHPYIFVVNQSENILSNKKSKIQIMHDYVSLGQDKPFVTIQQDASCVMDETDSLPKFNLAKREYRHHNIVEERSINCKDFSKLNSSYFQQSYTTKKDENFHKKLISMINDNEIEKLSGEMYSLEYYRSCNKLLSMKSRPLANLRQTNEDAERNHKALVDLNKKCRSIIRKFKNGLFTIDTIFKWNELRSKDGPMSCSICRCNKFFKRPGSIANHIYRVHERILREALERGELHKILEKNQKQTGDWSIENDQHLTIPCEELSQQNYCTVMNSMGFKLLHESSPFLNSCNSSLDNYDSSYSMTEQKQNLDSNVEKYELEQALKTLKQDFDKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H4Z3</accession>
    <name>A0A8J2H4Z3_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Similar to RE2: Retrovirus-related Pol polyprotein from transposon RE2 (Arabidopsis thaliana)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS435</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001114">
        <property type="protein sequence ID" value="CAG5073492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H4Z3"/>
    <dbReference type="OrthoDB" id="7696058at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35317:SF29">
        <property type="entry name" value="CCHC-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35317">
        <property type="entry name" value="OS04G0629600 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14223">
        <property type="entry name" value="Retrotran_gag_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5073492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="151" mass="16796" checksum="B388ADF6D19E62D3" modified="2022-05-25" version="1">MNAERSSRIELLNSSNYEVWRIRMKAVLLGHDKWGYVSGNIPAPDAGSGDRAATSALNKWKENDEKALAEIILSVGEAELRSISNCTTSKEAWEKLQSIYASKGPVRKIELLTDITSFKIDEDDDFRGRLDKFSSAVEQLAGMKIDIPTTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H504</accession>
    <name>A0A8J2H504_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS555</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001114">
        <property type="protein sequence ID" value="CAG5073676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H504"/>
    <dbReference type="OrthoDB" id="106784at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5073676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="70" mass="8181" checksum="C117DF4559E28A17" modified="2022-05-25" version="1">MMELSTQDYALSNWLKVPYKQIGPVPATYICRRYQKPAHWVYQCQFMVNGKPASIKKAKGIPQTMMTEHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H530</accession>
    <name>A0A8J2H530_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similar to wgn: Tumor necrosis factor receptor superfamily member wengen (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS888</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001114">
        <property type="protein sequence ID" value="CAG5074116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H530"/>
    <dbReference type="OrthoDB" id="6126731at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0675">Receptor</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5074116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="173" mass="19793" checksum="18661DFA85684DE3" modified="2022-05-25" version="1">MKASELLWQFSQPENNPEALTQMDNSQIESHSRSNYNNQVIDKQLLVSEVNDTIKLTKNNYESINVAWDWQTSALVLAVCACIIFFIVAGCSAIIYVRQWRRMKRNFEPDRKRDTRVVIPTGWPEIGGNLYIEETAGESSSLSPASPINKSKQLKQIQRNIQNIIAQKSQFNC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H5C8</accession>
    <name>A0A8J2H5C8_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phosphatidylinositol-3-phosphatase SAC1</fullName>
            <ecNumber evidence="1">3.1.3.64</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Phosphatidylinositol-4-phosphate phosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Suppressor of actin mutations 1-like protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HICCMSTLAB_LOCUS406</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:55652"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57880"/>
            <dbReference type="ChEBI" id="CHEBI:58178"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="3">
            <dbReference type="Rhea" id="RHEA:55653"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:12316"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57880"/>
            <dbReference type="ChEBI" id="CHEBI:58088"/>
            <dbReference type="EC" id="3.1.3.64"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="2">
            <dbReference type="Rhea" id="RHEA:12317"/>
        </physiologicalReaction>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.64" evidence="1"/>
    <dbReference type="EMBL" id="CAJNRD030001114">
        <property type="protein sequence ID" value="CAG5073463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H5C8"/>
    <dbReference type="OrthoDB" id="405996at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004438">
        <property type="term" value="F:phosphatidylinositol-3-phosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043812">
        <property type="term" value="F:phosphatidylinositol-4-phosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002013">
        <property type="entry name" value="SAC_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45662">
        <property type="entry name" value="PHOSPHATIDYLINOSITIDE PHOSPHATASE SAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45662:SF2">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-3-PHOSPHATASE SAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50275">
        <property type="entry name" value="SAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="167"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="194"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="SAC" evidence="8">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00036631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00036807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00040795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00041396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00041911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAG5073463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="226" mass="25853" checksum="5778CF4959412C89" modified="2022-05-25" version="1">MDRLAHDQEQMGYFLLSRDGSLLSVQDGVFRTNCIDCLDRTNVVQSMLAKRALVDALNKLSILRRIEEHPSFETLFKEVWADNADIISTQYSGTGALKTDFTRTGKRTRMGALRDGINSLTRYYKNNFADGFRQDSLNLFLGRYVIQDGECMQLKCPLDYERNWRYATFPLVLLVASSMLIAHVILPSTYSTEVLLYMLFWGAMVAGTFATIIHHGRQYVDKPKLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H5E6</accession>
    <name>A0A8J2H5E6_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Dihydropteridine reductase</fullName>
            <ecNumber evidence="7">1.5.1.34</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">HDHPR</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Quinoid dihydropteridine reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HICCMSTLAB_LOCUS1811</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the conversion of quinonoid dihydrobiopterin into tetrahydrobiopterin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>5,6,7,8-tetrahydropteridine + NAD(+) = 6,7-dihydropteridine + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17869"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28889"/>
            <dbReference type="ChEBI" id="CHEBI:30156"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.5.1.34"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="12">
            <dbReference type="Rhea" id="RHEA:17871"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>5,6,7,8-tetrahydropteridine + NADP(+) = 6,7-dihydropteridine + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17865"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28889"/>
            <dbReference type="ChEBI" id="CHEBI:30156"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.5.1.34"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="11">
            <dbReference type="Rhea" id="RHEA:17867"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.34" evidence="7"/>
    <dbReference type="EMBL" id="CAJNRD030001116">
        <property type="protein sequence ID" value="CAG5075688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H5E6"/>
    <dbReference type="OrthoDB" id="1204at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004155">
        <property type="term" value="F:6,7-dihydropteridine reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070404">
        <property type="term" value="F:NADH binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070402">
        <property type="term" value="F:NADPH binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006559">
        <property type="term" value="P:L-phenylalanine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006729">
        <property type="term" value="P:tetrahydrobiopterin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05334">
        <property type="entry name" value="DHPR_SDR_c_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000157">
        <property type="entry name" value="Quinoid dihydropteridine reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15104">
        <property type="entry name" value="DIHYDROPTERIDINE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15104:SF0">
        <property type="entry name" value="DIHYDROPTERIDINE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0521">NADP</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0783">Tetrahydrobiopterin biosynthesis</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00039153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00039520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00041348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00042518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAG5075688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="216" mass="23387" checksum="D8B9F050486F1C52" modified="2022-05-25" version="1">MASNVLGRVFIYGGKGALGSVCVSQFKAKKWWVGNIDMKENESADANIVVNSSHTWKEQETAIISQMKEILKDEKLDGIICVAGGWAGGNAAHKDFLENSELMWKQSVWSSTIASSIAVHYLKEGGFLSLTGAKAALEGTPGMIGYGMAKAAVHQLTKSLADENSGLPKEAMVVSILPVTLDTPMNRKWMAKADTTSWTPLEFVSEYDVLEVGKQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H5P1</accession>
    <name>A0A8J2H5P1_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS1355</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001116">
        <property type="protein sequence ID" value="CAG5075201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H5P1"/>
    <dbReference type="OrthoDB" id="6922936at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5075201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="119" mass="13810" checksum="57BAF6BF9EA736EB" modified="2022-05-25" version="1">MSTLWHTTNSQQSSQGSQNIIIETGRYPDQPSTSSNLNIMEVNNEEPVTAISSTLQNKRDRQKRYREKNREKLSQREAERRRRLQNAEKSIIIIDEVTTNSRNLTGLGEMEHELIVNKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H5U0</accession>
    <name>A0A8J2H5U0_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">limulus clotting factor C</fullName>
            <ecNumber evidence="9">3.4.21.84</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HICCMSTLAB_LOCUS2100</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>Selective cleavage of 103-Arg-|-Ser-104 and 124-Ile-|-Ile-125 bonds in Limulus clotting factor B to form activated factor B. Cleavage of -Pro-Arg-|-Xaa- bonds in synthetic substrates.</text>
            <dbReference type="EC" id="3.4.21.84"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.84" evidence="9"/>
    <dbReference type="EMBL" id="CAJNRD030001116">
        <property type="protein sequence ID" value="CAG5076119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H5U0"/>
    <dbReference type="OrthoDB" id="546450at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042381">
        <property type="term" value="P:hemolymph coagulation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000120">
        <property type="entry name" value="Putative serine protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033116">
        <property type="entry name" value="TRYPSIN_SER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24252">
        <property type="entry name" value="ACROSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24252:SF7">
        <property type="entry name" value="HYALIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00135">
        <property type="entry name" value="TRYPSIN_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0353">Hemolymph clotting</keyword>
    <keyword evidence="4 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 10" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0720">Serine protease</keyword>
    <keyword evidence="3 11" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0768">Sushi</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035266480" description="limulus clotting factor C" evidence="11">
        <location>
            <begin position="23"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="12">
        <location>
            <begin position="85"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00052079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00066707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAG5076119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="327" mass="36237" checksum="1615CB77C764E765" modified="2022-05-25" version="1">MRVFVFCAVLFVCFFTFFTVNSLPRNQNSWADKPFDFYNLSARSNNDLTIDDGFIVNTNPPKIAYPKMPNTCSNCICGVGRKTRIVGGTTATIGEFPWMIAMSKHGQFHCGGSLLTKRHVLTAAHCLEGFDKRHFEIFIGKQDFDKSSSAVIRRRIKSWTVHEDFNTYNLDNDIAVIEMDRSIPVGGAIRTACLPENRAIDYTGSLATAIGWGRTTEGGEVSSTLRKVELPVLSDEECDEAGYQKSRRTTNMFCAGYLEGKRDACSGDSGGPLLVEGPYGHLEVIGITSFGRGCARPRYPGVYTKLTNYLGWLRDNLDGECICPPAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H709</accession>
    <name>A0A8J2H709_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Similar to nau: Myogenic-determination protein (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HICCMSTLAB_LOCUS3155</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5080965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H709"/>
    <dbReference type="OrthoDB" id="10049614at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007517">
        <property type="term" value="P:muscle organ development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045663">
        <property type="term" value="P:positive regulation of myoblast differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19699">
        <property type="entry name" value="bHLH_TS_dMYOD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.280.10:FF:000005">
        <property type="entry name" value="Myogenic factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002546">
        <property type="entry name" value="MyoD_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039704">
        <property type="entry name" value="Myogenic_factor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11534">
        <property type="entry name" value="MYOGENIC FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11534:SF9">
        <property type="entry name" value="MYOGENIC-DETERMINATION PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01586">
        <property type="entry name" value="Basic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00520">
        <property type="entry name" value="BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BHLH" evidence="5">
        <location>
            <begin position="130"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="33"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="64"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAG5080965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="204" mass="22972" checksum="7DE786AB13E535A0" modified="2022-05-25" version="1">MMTLMTDVGGYAYDSRASYDGYHSHRRHFYNNPDNEFLQGYVPVRNDDRNSHHTRTRSADNSDDASSVVSADASADPESASADGDETNESEQGIEHVPHPHVLDATSPHGARRCLLWACKACKKKTVTVDRRRAATLRERRRLRKVNEAFEVLKRRTSNNPNQRLPKVEILRNAIEYIESLEALLQGNRPSGNSASHVATDNMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H7Z6</accession>
    <name>A0A8J2H7Z6_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Similar to Wdr47: WD repeat-containing protein 47 (Mus musculus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HICCMSTLAB_LOCUS3281</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5081418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H7Z6"/>
    <dbReference type="OrthoDB" id="187712at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22249">
        <property type="entry name" value="UDM1_RNF168_RNF169-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006595">
        <property type="entry name" value="CTLH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006594">
        <property type="entry name" value="LisH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040067">
        <property type="entry name" value="WDR47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057749">
        <property type="entry name" value="WDR47_COR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19863">
        <property type="entry name" value="NEMITIN (NEURONAL ENRICHED MAP INTERACTING PROTEIN) HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19863:SF11">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 47-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25602">
        <property type="entry name" value="WDR47_COR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00668">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50897">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50896">
        <property type="entry name" value="LISH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CTLH" evidence="3">
        <location>
            <begin position="105"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="473"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="552"/>
            <end position="579"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG5081418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="597" mass="66750" checksum="2B58B3AC25947A67" modified="2022-05-25" version="1">MFCYLCEVVCKTGTVQLALVSPINSSFNLLTKKSQVSSPPPTYLKNKSISQLNKMLRIRYVMPAAHLTLREEDVVRLTLEFLHSRDLHITQLSLERETGVINGQYSDDVLFLRQLILDGQWDDVLEFIQPLEALPDFDMKKFTYSILRHKYVELLCIKSEANIIAGANGSVDNAVEEVVKVLSDLEKVAPSKEEYSSLCLLLTLPRLTDHLQYKDWNPSNARVQCFREVHLLVEKFLPGDRKSDPSHPVASAKNDRLIQLIIKGILYESCVNYCQAKATGSKESEQVEMSFSRLLDGSVGFSDSDLSLLSWLQSIPPETFAVPFAQRTLNVDVERLERPSLETSWTEHMLITPIKPKTFPHSAMPFTRPRSAADMMSRSLVPALEAGLGPRSPGPKNTTLPSAALMALSTGDINPMSRSSFASFHLTGFKNNKIMNTSVDRLFENEGDVFLSSSYAEFQQQLPSIQETIANAQANTAARARHKTNPSSASTPERRLPGRESPALSTARSSRRDSLADKPTGVAAKIPEPTVIPARGVIAGDNLDQSYNGDLFKEYQKQKQKLQETIQQKERERDELVRQLSAPISAQLVDNRLQNET</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H843</accession>
    <name>A0A8J2H843_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS3871</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5083556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H843"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5083556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="302" mass="35129" checksum="CC10A86E1036FAE9" modified="2022-05-25" version="1" fragment="single">MFNQQFQHFYVIRKSSDTHWRVGIVSVIANSSVYISTLADEKFSDLICIQLDSKFQRCLDLSPIKLPVPNVLSPSALCLHCSPGGSLQIHRHLHKEPSEEYFFISIADEEVYQFLVVYMRSHVKNSIFEIFFAASVSGVTKIKKHFMNKSSRKISRKNFIENIFHLIEQFSSLTSFFQAILNHSCVQRKLGRHFVVKLIFISILDPQRQFVIRSVQYIKQGKSSHYSVNVKASRHQLNNMLLHNLTAHFFLSIAINRQFAMIAYNIDITTCIQKILKTRLRFISVSVYEPIPWKMKTRLLVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H860</accession>
    <name>A0A8J2H860_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS3479</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5082181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H860"/>
    <dbReference type="OrthoDB" id="7700219at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5082181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="135" mass="16282" checksum="DDF66F137D22A487" modified="2022-05-25" version="1">MIEKDGYHYWKDDKKRGKDKEQWARIRCGNIGRAYKKGYTEWTCRLCEENMETLTHLIKCKEIKKGVNEKERKYLEKWDKLVEEEEIEREICKILKGELDVNFCEIFRKVEKSIRSKTEAEKIGEESAEVEQRTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H877</accession>
    <name>A0A8J2H877_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Venom protein 15</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS3986</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5083995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H877"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035311655" evidence="1">
        <location>
            <begin position="21"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5083995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="36" mass="3918" checksum="0AB7F0EDACAC460B" modified="2022-05-25" version="1">MKILSIFLVVLVIFAVAVNAKSKSEETTMPSPNIIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H8D3</accession>
    <name>A0A8J2H8D3_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">EGF domain-specific O-linked N-acetylglucosamine transferase</fullName>
            <ecNumber evidence="1">2.4.1.255</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Extracellular O-linked N-acetylglucosamine transferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HICCMSTLAB_LOCUS4054</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = 3-O-(N-acetyl-beta-D-glucosaminyl)-L-seryl-[protein] + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:48904"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:12251"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:90838"/>
            <dbReference type="EC" id="2.4.1.255"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-threonyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = 3-O-(N-acetyl-beta-D-glucosaminyl)-L-threonyl-[protein] + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:48908"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:12252"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:90840"/>
            <dbReference type="EC" id="2.4.1.255"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.255" evidence="1"/>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5084244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H8D3"/>
    <dbReference type="OrthoDB" id="529273at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097363">
        <property type="term" value="F:protein O-acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049625">
        <property type="entry name" value="Glyco_transf_61_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007657">
        <property type="entry name" value="Glycosyltransferase_61"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20961:SF148">
        <property type="entry name" value="EGF DOMAIN-SPECIFIC O-LINKED N-ACETYLGLUCOSAMINE TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20961">
        <property type="entry name" value="GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04577">
        <property type="entry name" value="Glyco_transf_61"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="25"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyltransferase 61 catalytic" evidence="12">
        <location>
            <begin position="349"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00040944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00042574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF04577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAG5084244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="530" mass="61862" checksum="BD72C08303E75BD5" modified="2022-05-25" version="1">MTIKNYLKLFINVGTIMINLSKKSYVSFIVVIYLITNVCASDIYKNINLPANHLKYYFNSLPIIARECQHDPACPYKEHLNEKACWGYEDNCKQENAFSIPYCPGDHKGWVSSKKAQIDTFYSQGDFGYVRDQRNEMTLLCEPFFKEDSSLECSEHLRFCRGRNIMINFTDLTYRKEPIRYAMDVLKEGQIGGYCKLNEKKLQENADHISALQSWGPELRYFRKLPRRPIVEGDCDIVIEKPTYIMKIDATVNLYHHFCDFFNLYASLHVNNTHPSTFSTDNHILIWESYNYHSAFQDTFEAFTKNSLWDLKTFRGNTVCFKNLVLPLLPRMIFGLFYNTPLIYGCEKSGLFKAFSEYILHRLKIPMYQRKDNKIRVTLLSRDTRYRRILNEDELVIYNREVPFKKQLEITRNSDVFIGIHGAGLTHALFLPDWAAVFEIYNCEDASCYKDLARLRGVKYFTWEDDEKLTQQDPGNHPDGGAHAKFTNYSFNVTEFLRIVSLAADSVTSNPDYKKFLSSQTCLKPPKVEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H8Y2</accession>
    <name>A0A8J2H8Y2_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Mitochondrial (Homo sapiens)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HICCMSTLAB_LOCUS3375</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5081774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H8Y2"/>
    <dbReference type="OrthoDB" id="10249250at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005740">
        <property type="term" value="C:mitochondrial envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045277">
        <property type="term" value="C:respiratory chain complex IV"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006123">
        <property type="term" value="P:mitochondrial electron transport, cytochrome c to oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00924">
        <property type="entry name" value="Cyt_c_Oxidase_Vb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.11.10:FF:000004">
        <property type="entry name" value="Cytochrome c oxidase subunit 5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.11.10">
        <property type="entry name" value="Cytochrome c oxidase, subunit Vb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002124">
        <property type="entry name" value="Cyt_c_oxidase_su5b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036972">
        <property type="entry name" value="Cyt_c_oxidase_su5b_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10122:SF0">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT 5B, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10122">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT 5B, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01215">
        <property type="entry name" value="COX5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57802">
        <property type="entry name" value="Rubredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51359">
        <property type="entry name" value="COX5B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="3">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="88"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="108"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR602124-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG5081774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="122" mass="13756" checksum="2852D5AEB473345F" modified="2022-05-25" version="1">MASLCRRAVFQACSRTFSTAPVCGKYRKDQMPDPMDLATGLEKRELLAYQSGNDDPFMMKGIIRGPGTKDQPNEVPSAFNSRIVGCICEEDSTSILWMWLHSGIPRRCKCGHWFKLVKKTPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H8Y7</accession>
    <name>A0A8J2H8Y7_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS3659</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5082815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H8Y7"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5082815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="136" mass="15307" checksum="A6210882C0BC8222" modified="2022-05-25" version="1">MDIEFKSDSSTNRSPVILVESRRLSEPNLRCVEAASLVGIPALLDTVDSSKYQEDDADRLVVLLLPVLPVVLQPEAVGRFPLLFLRVSSSRDDSAPLHFLRYKTESLKLDIIQLDIIRLITSTNLLLTYKTKRTVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H980</accession>
    <name>A0A8J2H980_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="20">Similar to nAChRalpha1: Acetylcholine receptor subunit alpha-like 1 (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">HICCMSTLAB_LOCUS4759</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="16">Postsynaptic cell membrane</location>
            <topology evidence="16">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5088204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H980"/>
    <dbReference type="OrthoDB" id="5975154at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045211">
        <property type="term" value="C:postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098655">
        <property type="term" value="P:monoatomic cation transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007271">
        <property type="term" value="P:synaptic transmission, cholinergic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.390:FF:000022">
        <property type="entry name" value="Nicotinic acetylcholine receptor subunit alpha4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.390">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036719">
        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038050">
        <property type="entry name" value="Neuro_actylchol_rec"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006029">
        <property type="entry name" value="Neurotrans-gated_channel_TM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02932">
        <property type="entry name" value="Neur_chan_memb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90112">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane pore"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="15" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="14" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="9 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-0628">Postsynaptic cell membrane</keyword>
    <keyword evidence="11 20" id="KW-0675">Receptor</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0770">Synapse</keyword>
    <keyword evidence="4 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 18" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="212"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel transmembrane" evidence="19">
        <location>
            <begin position="15"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="81"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00034104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF02932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="CAG5088204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="260" mass="29750" checksum="CDEB2851FD06565B" modified="2022-05-25" version="1">MLKKLFLYPYINIDICVTVVVLNVHFRSPQTHKMAPWVKRVFIHILPRLLVMRRPQYKFEPSRFSSGRVVNMRPVRGKEKASYYPYHPSSQEDSEEHLTPKRFSSRHVSKEDLSPSSLAEQARFGGSCLIHGPIPPLPLNAECEDLPGVAGIEDIKSPVLRNSSTFSHSCCPPEIHRSCICVRFIAEHTKMLEDSTKVKEDWKYVAMVLDRLFLWIFTLAVLVGTAGIILQAPTLYDDRVPIDKKFSEYAKDTVVRCPPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H992</accession>
    <name>A0A8J2H992_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Similar to CG5262: Transmembrane protein 104 homolog (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HICCMSTLAB_LOCUS4441</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5087187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H992"/>
    <dbReference type="OrthoDB" id="294541at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16189:SF0">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16189">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 104-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="103"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="170"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="202"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="58"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG5087187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="261" mass="29348" checksum="BD341AA781916A05" modified="2022-05-25" version="1">MSLILNKIITWHSRCLNKIHLINIPPGFITVTFVIESMATANAIKSWQQLKTRKKALERIEDNSESEETPLVEPSGSNEDEELSSKFYSINQKIEMGEMATLFFNKTGISLFYICLAVYLYGDLSIYAAAIGKSLADVACNYIPSNLTCNDTIPDNVSCWKGSSVTRFDAYQIFLTTFILMLGPFVFFNVQKTKYLQVLTSVMRWLAFSIMIIYALRILIVNGPQGSPPVANFNGKNPGTFWCLRLFLHVPSFITSTSSTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H9S2</accession>
    <name>A0A8J2H9S2_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Odorant receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HICCMSTLAB_LOCUS4607</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Cell membrane</location>
            <topology evidence="1 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the insect chemoreceptor superfamily. Heteromeric odorant receptor channel (TC 1.A.69) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5087784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H9S2"/>
    <dbReference type="OrthoDB" id="8185860at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005549">
        <property type="term" value="F:odorant binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004984">
        <property type="term" value="F:olfactory receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004117">
        <property type="entry name" value="7tm6_olfct_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21137">
        <property type="entry name" value="ODORANT RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21137:SF35">
        <property type="entry name" value="ODORANT RECEPTOR 19A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02949">
        <property type="entry name" value="7tm_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 10" id="KW-0552">Olfaction</keyword>
    <keyword evidence="8 10 11" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="9 10" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="40"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="129"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="246"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="273"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU351113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAG5087784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="376" mass="43005" checksum="96F9FACA376A8E12" modified="2022-05-25" version="1">MIFKATPEFAIAFTKFTSLLSTSWPNYPGSPKWKFVVFQIRWWATFFLAVSAFLPMCYGAYNHWRNILSFTKSLFDAVNTIQTFVKMILCKIHYKKMQYLLWEMEKYVLNAKPHDREMFILYIKRCGKLHVVSMICGFMTIAMIIIAPIGMPQPFPNIVEYPFSTEGHPVFELIYLHQSCATIHCLSILTFDCQIALLLWYAGARLELLSQEFHDAADYKSFNECVKKHQYLLGYIQDIVISSRHILATTVINCVLATITSGIHIVGNEPVAIKVPFVVASAIISVVLYVTAWPCEHLAHMCKIVGIGLYNSPWFQNTKQMNTSVLIVIQRSQKVASIDVAGILPSLSLSYYATFLSKIFSYFTTLRVMLSKMEID</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HA09</accession>
    <name>A0A8J2HA09_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similar to DDB_G0290685: Uncharacterized protein DDB_G0290685 (Dictyostelium discoideum)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS5203</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5089352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HA09"/>
    <dbReference type="OrthoDB" id="70874at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="317"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="944"/>
            <end position="966"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="994"/>
            <end position="1039"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="328"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="339"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="946"/>
            <end position="957"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1039"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5089352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="1039" mass="116817" checksum="1E12BB9CE4F988C2" modified="2022-05-25" version="1" fragment="single">MKVTIFIISIVSSQIQFHHCCGSTDLDNPPEPRWNITLDNPTKKRYQRSISYDASGEVRWDGSETAGTGYVPKTLGYLKSSSSSRPTVPCFIKGTSVRFQGKPVYIDGSTGYIDGAVCWVKGNTNGRQGKTCYARGTIVSHLYTSKVPELACVVQESIGFVIGIRYGRGVPPYRLTESSDLVATACTMSTTYNYVLGTVLYEEGTSGYVNGSSCWVRGLRHDGLGRTCDVPGTAGDLVGTDGRVSGTACYLQFSTTYVLGTRYYQMPNCHANSFPLQELNCNEQVNSNVPGTNLNEQVNRNVPGTNFNEQVNRNVLGTNRDHGRTEQVQRTGVNTQRTSSESHALGSASSQTQRSNDFTIKFVGHEITASGDHVQIFCYLRPSFLQVGSPHFVEGSSGYVDGSTCWIEGTVSSTQPNLCYVEGSIKTLQRHKVSKVVCFVSSTSGYDLENNYVTGTRSYYQHPCRVGEVTDYSDGTTTYFRGSRGFVYRNTCWVEGVRKDGRKGVCYRRGVTYHVKNNSENSHKACYFTVNYAFVMDDRYYELNSDSKVEEDSFRHSEISLHENSESSVHWESRSLINDGEIKTIPHEIHNHGSIHNQDHGTVNHGSIYNQDHGTVNHGSIYNQDHGTVNHGSIHNQDHGTIHNQDHGTIHNQDHGTIYNQDYGTVNHGSIHNQDHGTIHNQDYGTVNHESIHNQDHGTIHNQDHGTIHNQDYGTVNHGSIYNQDHGTIHNQDHGTIHNQDYGTIHNQDHGTIHNQDHGTVNHGSIHNQDHGIIHNQDYGTVNHESIHNQDHGTIHNQNYGTVNHESIHNQDHGTIYNQDHGTIHNQDYGTVNHGSIHNQDHGTIHNQDHGTIHNQDYGTVNHGSIHNQDHGTIHNQDHGTIHNQDYGTVNHGSIHNQDYGTIHNQDHGTIHNQDHGTVNHESIYNQDHGTVQEGNNRRIYTQGSENERDSNSDFESRQTTNDFQQEHHKQYEENVNYNYGSSENSQINWSVGNHHEEQSKEEINRSDEQSRRNFIMRGKDQSRETGRNQQDFKNHFYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HA29</accession>
    <name>A0A8J2HA29_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein yippee-like</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HICCMSTLAB_LOCUS4482</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the yippee family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5087314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HA29"/>
    <dbReference type="SMR" id="A0A8J2HA29"/>
    <dbReference type="OrthoDB" id="6407410at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034751">
        <property type="entry name" value="Yippee"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004910">
        <property type="entry name" value="Yippee/Mis18/Cereblon"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039058">
        <property type="entry name" value="Yippee_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13848">
        <property type="entry name" value="PROTEIN YIPPEE-LIKE CG15309-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03226">
        <property type="entry name" value="Yippee-Mis18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51792">
        <property type="entry name" value="YIPPEE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Yippee" evidence="5">
        <location>
            <begin position="14"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU110713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAG5087314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="114" mass="12975" checksum="7BC3034F9485B63D" modified="2022-05-25" version="1">MVKTFQAYLPSCHRTYSCIHCRAHLANHDELISKSFQGSQGRAYLFNSVVNVGCGPAEERVLLTGLHAVADIYCECCKTTLGWKYEHAFESSQKYKEGKFIIELAHMIKENGWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HAD9</accession>
    <name>A0A8J2HAD9_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS5632</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5090443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HAD9"/>
    <dbReference type="OrthoDB" id="7692610at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5090443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="302" mass="35225" checksum="690C4A8C97AD9C31" modified="2022-05-25" version="1">MLEQSMARAFESHQRYDRQSSNTLETKISEDSKIYFPTHVKTQVEETCQKENGNCDWESMVRFALKEVYDDNIANYTAKGHTKGSNGNKRPQIDNQLYNAIFGWVREKVGPTQIITTKMFNRAINKFSYNKRTNDNMKPNCSNKSEEADLFSEENLQFFKKIVKIAEESFNMQQRELLPERQLHQLADVFTQPSKNNVKISPNYEVYLPQGIYLFISRHSETARGEYNWRTLVKTTLLEIYGNDLKKYSAKGTRGGCPPINVELYRALYDWASSQVEKIILEDEFVDYINDLTANKRKGKNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HAM1</accession>
    <name>A0A8J2HAM1_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Structural maintenance of chromosomes protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HICCMSTLAB_LOCUS5537</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the SMC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5090215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HAM1"/>
    <dbReference type="OrthoDB" id="7673698at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008278">
        <property type="term" value="C:cohesin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007062">
        <property type="term" value="P:sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1060.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003395">
        <property type="entry name" value="RecF/RecN/SMC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024704">
        <property type="entry name" value="SMC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010935">
        <property type="entry name" value="SMC_hinge"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036277">
        <property type="entry name" value="SMC_hinge_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18937:SF12">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18937">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES SMC FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06470">
        <property type="entry name" value="SMC_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02463">
        <property type="entry name" value="SMC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005719">
        <property type="entry name" value="SMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00968">
        <property type="entry name" value="SMC_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75553">
        <property type="entry name" value="Smc hinge domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="4 8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0498">Mitosis</keyword>
    <keyword evidence="5 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SMC hinge" evidence="9">
        <location>
            <begin position="511"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="238"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="717"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="803"/>
            <end position="902"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="1021"/>
            <end position="1062"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR005719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAG5090215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="1224" mass="142609" checksum="A79B09C9304923D7" modified="2022-05-25" version="1">MMESAILNTKISRLEISFFKSFAGVNKIYPFELLNGVYGLNGSGKSNFLDAFAFCFNENLRKLRIRNAKQLIHIHADESEKTYVKCTFSFADLTEKSFTKEIVGSSFNYSIDDQEVEEKTYVQELINIGINIKNNIIVYQEDIQAIASLNGKNLTNLFERVSGSISFRRDYQSLLSQVEQARLDGKKSFNNKKELLTTQKRLRDISKTNRISHGLQEHYEKYLKKFILANLYILDVNIKTAEKNIQKLLKIKEKKENKIKERERILKELQKNIESSEKKIEKYELQASVNFSKKTTVRANFEELNEQIVKDKKKIESAKKNLEKAQEFDESRAKAIKELEDALKIENEKKKEYLDASNHDPDYWEKMEQQENEYQRLKTIVSEKNVAIIQALDILEYRRRGFDNQMENFHRQLNDLNNKLEMQIKLLSNNESGLKEIVNKIKEIEKESEEVRQDVNKLKMDTETSEKQRIELMTKLDEIDEKIHSLKLDKSQIQIAKWEEETLEYLKKTVKGVFGRMYQVCEPIHNRYKIPMAKVFGHFFSAIIVDTRKTAMKCVEILEQSCLTYEKFLPLDSLDAPVLQERLRDPSLYDSINNVKLLYDVLQFPTEISRAVLFVTKNTLVCELSKEANHVAYDLKSKNKHNCVSLDGTFYKTNGSFSGGKSSISKRVQLIDSQMSENLKTRKKEIMNAIKEGQKYLDNQSELKSLESKQNNLNWKIKYLKDAYNKMESECNELKESISKLTDEKKHLQLQCDEIQKELDKVHLECQELQNQNASIENKIYQDFCKNLGIKCISEYLNQSRLQEEKKSNLRKIKEQIERIESCIEYESNKNTSNNVKRWSDVVKNLENDLLDKKTTMKGLEKDLQALEKEEQLDKQKLDPLIEELNINVTELKKLRADIEKDKNSIPQLLSQIQNPSENGATLKADFHDWILRAKNEMIELPLLENDISLNDLYELIESVEPEDYDSQKLEEIYNLEQNLCFNYESLLEDSADGGNIDELLKVYEDELASLRQKLIAMPTSSTVESELDEVKKKIDQLNKEHREHLKELKKLTSEFEKVKKLRYDTFMESFESIREKLGAVYKKITGRNSAQAFLLTVNPEEPYLDEIKFKFVPPNKQNRGPVEPSGGEKTLAALSLLFSIHGDQHVPILLLDEIDADLDKKNVNNVIKYLNEAKKDQQIIFISHNDSVIKCADRVSGFYAATKSDHSKRTIYVSLDLNKYKNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HAS6</accession>
    <name>A0A8J2HAS6_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Similar to Arfgef3: Brefeldin A-inhibited guanine nucleotide-exchange protein 3 (Mus musculus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HICCMSTLAB_LOCUS5954</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5092160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10002886at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032012">
        <property type="term" value="P:regulation of ARF protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1000.11">
        <property type="entry name" value="Arf Nucleotide-binding Site Opener,domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032629">
        <property type="entry name" value="DCB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015403">
        <property type="entry name" value="Mon2/Sec7/BIG1-like_HDS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023394">
        <property type="entry name" value="Sec7_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000904">
        <property type="entry name" value="Sec7_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035999">
        <property type="entry name" value="Sec7_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10663:SF344">
        <property type="entry name" value="BREFELDIN A-INHIBITED GUANINE NUCLEOTIDE-EXCHANGE PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10663">
        <property type="entry name" value="GUANYL-NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16213">
        <property type="entry name" value="DCB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09324">
        <property type="entry name" value="Sec7-like_HDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00222">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48425">
        <property type="entry name" value="Sec7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SEC7" evidence="6">
        <location>
            <begin position="435"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="472"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1838"/>
            <end position="1930"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="472"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="501"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1885"/>
            <end position="1896"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="1897"/>
            <end position="1920"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1921"/>
            <end position="1930"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAG5092160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="2126" mass="238298" checksum="3EB4495EB3182965" modified="2022-05-25" version="1">MEDLLQQIIRESQNSKLSNVRKAAQDAYDFMEKQQGLLRDPPHELRAKCLAAIQLSLETKRSKLVSYGLTGLHKILRDDRFQSPYEPEDDSLWLPAQMLHAMGSLLSQSDDTQTDMLKVLLQVACSAYWTMNGRLIIAILTTCCDAFENGNQAVRTAAQAATSQTLRSFCLFLDEECREMDEYAKQNKNVRERGVSCFNEALPILQYICSRLDEAQRKKFATAKSGNTVVFLLECLHTLISSLPQKIHTNQHFTTFLWQKFCPALIAFLGTPRVDKTFTSREGKDTEVGRGSGYLATTLSFDSHQAKTVYSIGTELVRLVGCVGPLRPVLESVFHRMLLYPPPQQRLESLKALRELLRSPSRMVDFAGPLLVDEEKTSQPQSDMALMRLVMDSIEESTTAGQPVLYASVSCVVAMLSALQELCEGKAVSHTYTGTINALYEDLEASDYKGPLTYLSMARLPKTYREQLELMNKTSGSESDSSGHGPSEDGDSTDTEGPQNESDEVNDDNSVDEIDYALENERERLRLEKLPKCLHVGRQFAEECNVDVERHNARQFVKILRSDLVPVVLNLRSNIEVDEALQNFASEYCQGVFAAQQKLQEKETSVETCALITIMNADGIYLATYAALLLNLKLIRMHYYLDSCAVPISEEMFVEEVHGSGVLVYLSATWLSELYQQILACNLLEKCGYNPASTENCALVNILVDVDGISGSQRGGQLLADYRRLEKAQLSRSEPTPEAEAGAKLSRRILSCCWGSMMTVLTAGLNPAKEETNKGILNRDTTRRGVRDTVVLALEGLHKAATLSNILGLQTRCGSIFGLLAKAACTEPAISKLRRTKDVLRLKLQNRATNIHTSHALSMEVLLGRGLELGSHGSDCWPHVFTCCLYVSKLEHDFFGRNQNLALPKLAKKEKKDSPIEKSDKNRPSFNIVDEEETCVDVYSFLSTPYTQNPTTETIPEIIQESNADNQSNGILPADYAAKIVCVLSQQVDRLFEDAALKLNLRALCSFLTALCQASKDQLFKTTDGSKDGKKFWWKKSKPREEELNVLLLSRLGEVMLKCVKSGRPLIHIMRIWSILGPHFMEAACHKDREISKRAVQCIHDSMAALLNEQIELPHFHFNEALFKPFENLLCLELCDGDVQDQIVSCICEFVETNRTEIRSGWRPLFGALRVASVGNSESVESAPLLEVFRVFLSTDNTLVFANAALDCILCLLKHIRGVGDPEISDSDPISNAEIRKMRLCLESLKCLLNCSDILSSMYRMPACPIFHSAARIQVSTIPQFVDPVIPNLELAKFDKNSESMQEIVPEISFELFNRIDRTQTITLQSMEKPSGILRVWYLLIEGLASATMICPRRYQPHTLETLFHLLRDILNVPGADFALYCVNHLLLPMVQNWLRITSKVVRGWDNFAPNFKQCCGLTTDLVVDYLTHLQGPEVTRRDELLPATTLMLKQLLLVMAECVIQQTESIARLGCACIRHVLISSGPLLTAEQWEVCGIACYRACSNSLQELHQLTMAFAPRSESFYGDLAQVKVAARRDATPEESERLRQLSAQVFLMAEQRSEPTYTDDRSYVFLLYPPSVASSLNPDLYIVRVQLRAMVVGLLVHQMLLHCIASVLLQGSIGSISSFCNMSSTSPVSPKPPEGKRRLTRNIETFLAALDLSFAAAVKFDSRPGLKFLVQKVANLEQPANLYQQAGAAWTIKILTLFELCLEEISDTGADLEVIKALISKNHNQEGNTQLVKLVKQLKSTFDSLCNNYVDVVLNRDGWHSVADGFSDRKIFLLVAQPDDFPEITSKEPLERFPLDKLEKETISQMEDPLERKEDYRSLKLFDLANDYYMESGPESEDDSDESKPSSRPRSPKKLVYRGSSECVFSGEADEANSSESNREFDPAKLDHDDDGDGNIDYGDDDDDDGKEELESNTDVSIDGSQTASRLEALDSDDLDLPLNFKDFNLERRLRLSDDCLSKTSRGFVSSDESYRSKSLVELHRASKFSELTITDSSEANNNKIGENTPEVFDDNVDDLLRDYERSRRGFRINPFLCEDNGNIEGRNISKDCEAHRRAWAETLSAALEWTLALPDDQLKPLLPVVVGGVRTLTKFAVDSNLKMKISSLFYRIVVLYGLTNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HBB8</accession>
    <name>A0A8J2HBB8_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ornithine aminotransferase</fullName>
            <ecNumber evidence="6">2.6.1.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Ornithine--oxo-acid aminotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HICCMSTLAB_LOCUS4783</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-proline biosynthesis; L-glutamate 5-semialdehyde from L-ornithine: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.13" evidence="6"/>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5088272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HBB8"/>
    <dbReference type="OrthoDB" id="425114at2759"/>
    <dbReference type="UniPathway" id="UPA00098">
        <property type="reaction ID" value="UER00358"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004587">
        <property type="term" value="F:ornithine aminotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019544">
        <property type="term" value="P:L-arginine catabolic process to L-glutamate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010121">
        <property type="term" value="P:L-arginine catabolic process to proline via ornithine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055129">
        <property type="term" value="P:L-proline biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000011">
        <property type="entry name" value="Ornithine aminotransferase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000152">
        <property type="entry name" value="Ornithine aminotransferase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049704">
        <property type="entry name" value="Aminotrans_3_PPA_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050103">
        <property type="entry name" value="Class-III_PLP-dep_AT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010164">
        <property type="entry name" value="Orn_aminotrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01885">
        <property type="entry name" value="Orn_aminotrans"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11986">
        <property type="entry name" value="AMINOTRANSFERASE CLASS III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11986:SF18">
        <property type="entry name" value="ORNITHINE AMINOTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00600">
        <property type="entry name" value="AA_TRANSFER_CLASS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="9" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAG5088272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="768" mass="85811" checksum="679BBCCC7453C077" modified="2022-05-25" version="1">MKPIVAAFQSGLRYGNNLKIVQLNFKRSITSQQVFDREDKYGAHNYHPLPVALCRGEGVFMWDMEGKRYYDFLSAYSAVNQGHCHPRIYKAMVEQACKLARKWAYKVKKIPDNSAKIIFAENNFWGRTLSAVSSSTDPTCYSGFGPFMSGFEIVPYDDLISLEKKLKDPHVCAFMVEPIQGEAGVVVPKDGYLKSVRELCTKYNVLWIADEVQTGLGRTGKRLAVDHENVKPDILILGKALSGGVYPVAGVLANDPVMLSIQPGEHGSTYGGNPLGCRIALEAVKVLEEEKLAENAQKLGVILREELNKLPKDIVTLVRGKGLLNAIVIDKKFDAMDICLKFKEHGLLAKPTHGHIIRLAPPLVITERQIHECCEIMSKSLKRCIISGSRDAKQVNRFISTAQQEIIKRDEQFAGPHFKPLPVVLAKGEGAFLWDIDNKRYYDFLAGFSTCNQGHCHPRLVKVMRDQCGKLHHVSRAFFTELHGELGEYLTRLFGFDKFIPMNTGVEAGDLSIKLARRWGYRVKKIPKDKATVLFAKNNFWGRSIAAASASTEPLCFTDFGPFVPNFEKIPYDDLTALEEALKSNPNVCAFMMEPIQGEAGVKIPKDGYLKGVRDLCTKYNVLWIADEVQTGLGRTGHRLAVDYENQKPDILVLGGPLACAVALEAVKILEEEKLAENAARLGKIVKEELEKIPKDIASEFRGRGLLCGIHINNEFANGWDVCLRLRDNGVLSRPAHGQFLRISPPLVIKEDQLREGLEIIKNTLLNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HE72</accession>
    <name>A0A8J2HE72_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 12">Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Ribophorin-2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">HICCMSTLAB_LOCUS8293</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="1 12">Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 12">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Component of the oligosaccharyltransferase (OST) complex. OST exists in two different complex forms which contain common core subunits RPN1, RPN2, OST48, OST4, DAD1 and TMEM258, either STT3A or STT3B as catalytic subunits, and form-specific accessory subunits. STT3A complex assembly occurs through the formation of 3 subcomplexes. Subcomplex 1 contains RPN1 and TMEM258, subcomplex 2 contains the STT3A-specific subunits STT3A, DC2/OSTC, and KCP2 as well as the core subunit OST4, and subcomplex 3 contains RPN2, DAD1, and OST48. The STT3A complex can form stable complexes with the Sec61 complex or with both the Sec61 and TRAP complexes. Interacts with DDI2. Interacts with TMEM35A/NACHO.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 12">Endoplasmic reticulum membrane</location>
            <topology evidence="2 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 12">Belongs to the SWP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5096605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HE72"/>
    <dbReference type="OrthoDB" id="432292at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008250">
        <property type="term" value="C:oligosaccharyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055375">
        <property type="entry name" value="Ribophorin_II_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055374">
        <property type="entry name" value="Ribophorin_II_3rd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056790">
        <property type="entry name" value="Ribophorin_II_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055373">
        <property type="entry name" value="Ribophorin_II_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008814">
        <property type="entry name" value="Swp1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12640:SF0">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12640">
        <property type="entry name" value="RIBOPHORIN II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05817">
        <property type="entry name" value="Ribophorin_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23861">
        <property type="entry name" value="Ribophorin_II_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23860">
        <property type="entry name" value="Ribophorin_II_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25147">
        <property type="entry name" value="Ribophorin_II_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 12" id="KW-0732">Signal</keyword>
    <keyword evidence="6 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035337229" description="Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2" evidence="12">
        <location>
            <begin position="20"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="562"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="595"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="624"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="domain" description="Ribophorin II N-terminal" evidence="13">
        <location>
            <begin position="31"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="Ribophorin II second" evidence="15">
        <location>
            <begin position="280"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="domain" description="Ribophorin II third" evidence="14">
        <location>
            <begin position="386"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="domain" description="Ribophorin II C-terminal" evidence="16">
        <location>
            <begin position="553"/>
            <end position="650"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00046750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU366029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF05817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF23860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF23861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF25147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CAG5096605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="655" mass="72253" checksum="D34A07C3CEDB8F83" modified="2022-05-25" version="1">MRILQWIIVVASVLGISLAATDITPSTNFYLTENDKLRLLKVLELGFQLNDVQSTFYAVLGYKLLDKAVPNSSDLCKYLIQNAGMDSNMTPESIFFIISAWQSIGSCQSLPVSSLSKILSEVIEKDTSTVPDLYHAISAYVALSQKLSQSTTSKVVKVLQAALKKDDNFLNVGYIYHIAANLGPAGDFALDKIEDTIVQADEIDGRFLRFEGGLSVTSLLVTGIAKLSAARKKPPPVTPEQIVKITNYLLSRHLVQSIKGAAMLLSALKTIANNDFNKPICITLAEGKNAVSAKQPLVNIKVSDIFGNSLPTVPTVIANSATSLDDDVVVISKKSFTPSPKDKTIFTMNFMNIKPHRGFYKVAIQAGSVSTTVTVKVLSEVKLDYLEIGTGDADQTTQSKLIKITYPKKLDHKIEADSQQKLVMKFSLLDITLSKSMRVHQAFVRLSKLIKSVEEKQLHEVIFVAEPDASNIYKFEMPVGSEAQTFGYYSGEYDVDLIVGDAVLNNSFQWRVATVDLKFPEQTGNEVVNMNKFVGYSKNSAIFTPKSEIKHMFREPEKRPPVFMSNVFTGLCLAPLLLLFILWATLDVNISKFPYSLSAIIFHFGLGGIFVLFGIFWLKLNMFVTLQYLLGLGISTFLAGSKLLSHIASNQKASR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HEA1</accession>
    <name>A0A8J2HEA1_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS8340</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5096698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HEA1"/>
    <dbReference type="OrthoDB" id="1271298at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5096698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="69" mass="8008" checksum="34A323D23D023859" modified="2022-05-25" version="1">MADETQEFRESVQEKILKIMAKENIKETPAAITKNKREKDLDYLFNCEALSQSFERMASFEIHAIATLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HEZ1</accession>
    <name>A0A8J2HEZ1_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Similar to FCHO2: F-BAR domain only protein 2 (Homo sapiens)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HICCMSTLAB_LOCUS7158</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <location evidence="1">Clathrin-coated pit</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5093832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HEZ1"/>
    <dbReference type="OrthoDB" id="5593455at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005905">
        <property type="term" value="C:clathrin-coated pit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030136">
        <property type="term" value="C:clathrin-coated vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048268">
        <property type="term" value="P:clathrin coat assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072583">
        <property type="term" value="P:clathrin-dependent endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07648">
        <property type="entry name" value="F-BAR_FCHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036168">
        <property type="entry name" value="AP2_Mu_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031160">
        <property type="entry name" value="F_BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054713">
        <property type="entry name" value="GMIP/FCHO2-like_FCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028565">
        <property type="entry name" value="MHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018808">
        <property type="entry name" value="Muniscin_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23065:SF15">
        <property type="entry name" value="AT02057P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23065">
        <property type="entry name" value="PROLINE-SERINE-THREONINE PHOSPHATASE INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22699">
        <property type="entry name" value="GMIP-like_FCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10291">
        <property type="entry name" value="muHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49447">
        <property type="entry name" value="Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51741">
        <property type="entry name" value="F_BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51072">
        <property type="entry name" value="MHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0168">Coated pit</keyword>
    <keyword evidence="3 5 6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-BAR" evidence="9">
        <location>
            <begin position="1"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="MHD" evidence="8">
        <location>
            <begin position="706"/>
            <end position="974"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="258"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="380"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="113"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="268"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="278"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="307"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="380"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="417"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="434"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="461"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="488"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="510"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="571"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="591"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="642"/>
            <end position="651"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAG5093832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="991" mass="109089" checksum="BF5ABBB93E9E2A3E" modified="2022-05-25" version="1">MKHGVVASKELADFLRERSAIEENNYKLLSKVAKQASNSSSIQGTFAPVWAALRGAAEKLASLHLQMAQRVSELIKDVSKYADELHKRHKAVKEEESSTLEVVQNIQSITVTLQKAKDMCQQKGLELEKLRKDNASQRELEKAEAKFKKAQDDYKVLVDKYTIVRNDFETKMSQACRRFQDVEETHLRQMKEFLNTYADVLQANHEQVGQVHIDFKRQCLDMTVDKLLEQFVQSKYTGFERPGVVEYDEVMTSLAEMANSTHQPESGSAGGSIGSGGVTADTTGTTAAIKEPPSSKSTNGETGVAGNKQNNNTTKKNQIQTAKVVVGDYHGDIAIDYNHDKDIKDNNKKYKIKDKNTDKDAPTKGSRRTTSLLNLFMSNSQERQRQAGSGSAPVTPQGDNPPSSISRNPLRGSKWFLRSRREKRKEKKAKKKKDSVDTNSNKEEKSDLSVSKLSAVPVQQIKEEEKDESRKSETPTPEVDEDGYCIRPKPDPWENEKGFYSSSDTESDDERERKIRVEIKPLSNGGAPMSASGRRGSNNDSDHHMKRSQSVSQQLGGKPSSDLLGLNLFNPSSTPSSASTPTASHPYAPLQSPPPLSTSPVPQPAPPQSAPPIQSHTRFPEGDLFSEVGDITPALPPKQSASSTPTGSIIIPRPPSRRSEGGPRGRMSPATISRADSVASLEFRTAGVGVGSSRGPSPLTIGLADTIPLAVAFHEIVHSYFRGTDETRCQVKLSGDMMLSFPAGIVAVLANNPSPAKLTFRMRNTNRLERLVPNTQLVSIDPTHTTTETTIFDFNMSALTTLLRRQAEQNPTASYFNVDILKYQIKAKEGAASCPFQIVAYWKCEPTHTDLKIDYKYNSRAMASPSPLLNLHVAAPIDGGFKSMHSKPSAQWLPDTNRLLWKFTELSQHSESNGVGSLKARVEIDRGPGTQGTIFTQFNCEGTTLSGVEFELVGPGYRLSLVKRRFVSGKYICDGDSDPRSRYAAPPSVSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HFB9</accession>
    <name>A0A8J2HFB9_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HICCMSTLAB_LOCUS6815</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5093425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HFB9"/>
    <dbReference type="OrthoDB" id="9990906at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052954">
        <property type="entry name" value="GPCR-Ligand_Int"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46641">
        <property type="entry name" value="FMRFAMIDE RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="56"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="146"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="180"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="227"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="272"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="332"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="6">
        <location>
            <begin position="75"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAG5093425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="379" mass="43783" checksum="19441525D099A9FB" modified="2022-05-25" version="1">MEENDKVMNKTFIGEECLIPLEVLDFIKNFNQSDLEVIWPCQVRHYWLSLQPFVQFVRILLAYVTPFVIFFGVILNAISFGILSKPILRFCDSGLSLYLRALAISDNAVLIFDYGVGVARSNFSAFNTLFMNSKFLCGFNSVSMEFFQITSTWLVVSLTWARVAAIIFPLQTFNKNHDCSAIIVIIILTCLSLIVSLTKLYCGGYESDSVFEYVTCQKIVIPWGIPMYFYIAFCTWLPLLFIFIGNVLLICHMRKSDVIHIQLTRTVQKKLNFINGTSGTLLAVSIVHLILLLPIGFVETLELYWDVILKKYPSKYIEENQQQYISWLQEKIGLFFHIYHWNFAINFILYYWTGKTFRDRVISALRSGTKFLCLTSVVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HFW2</accession>
    <name>A0A8J2HFW2_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Similar to HUWE1: E3 ubiquitin-protein ligase HUWE1 (Homo sapiens)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HICCMSTLAB_LOCUS6877</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5093488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="8068875at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14288">
        <property type="entry name" value="UBA_HUWE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.10:FF:000019">
        <property type="entry name" value="Putative e3 ubiquitin-protein ligase huwe1 isoform x2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.720.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010309">
        <property type="entry name" value="E3_Ub_ligase_DUF908"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010314">
        <property type="entry name" value="E3_Ub_ligase_DUF913"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050409">
        <property type="entry name" value="E3_ubiq-protein_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041918">
        <property type="entry name" value="UBA_HUWE1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018123">
        <property type="entry name" value="WWE-dom_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004170">
        <property type="entry name" value="WWE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037197">
        <property type="entry name" value="WWE_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11254:SF67">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE HUWE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11254">
        <property type="entry name" value="HECT DOMAIN UBIQUITIN-PROTEIN LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06012">
        <property type="entry name" value="DUF908"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06025">
        <property type="entry name" value="DUF913"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00627">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02825">
        <property type="entry name" value="WWE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00678">
        <property type="entry name" value="WWE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117839">
        <property type="entry name" value="WWE domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50030">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50918">
        <property type="entry name" value="WWE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="UBA" evidence="3">
        <location>
            <begin position="1418"/>
            <end position="1457"/>
        </location>
    </feature>
    <feature type="domain" description="WWE" evidence="4">
        <location>
            <begin position="1687"/>
            <end position="1764"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="504"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="777"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1102"/>
            <end position="1130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1376"/>
            <end position="1417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1770"/>
            <end position="1798"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2016"/>
            <end position="2044"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2269"/>
            <end position="2300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="777"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="797"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="816"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="839"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1119"/>
            <end position="1130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1386"/>
            <end position="1404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1771"/>
            <end position="1782"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="2020"/>
            <end position="2038"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAG5093488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="2424" mass="268275" checksum="46B0D96237307555" modified="2022-05-25" version="1">MKIDRTRLKKCTSEVPAECQALISKLRSCSHSELLEELKQIDAWTFGKCELFHWIDVLDLSDSILEAAVARSPDNPWELACDLPQNREAKELLLWVLHFTTLLIEHSFSRHLYNSMEHLVTLLSSRDMQVVLGVLSLLYMFSKRSNFITRLNSDKRQALLSRLNHLAESWGGKENGFGLADCCKEHPDKPFPPSATTLHFEYYAENPTTNEATSNSTVSSNTKKVGQTNLVTYIHIENVDKLGKTPAQIMNDLLKFYNVPQERQMALLTHIRLAHSFSDYRRRLQCVQARLQALSVLVYSNALQENAHSLLHAGLLEELVELLELPHPHLVDIRAAALRTLTSIIHLDRNPHFPKKPGSRLNMIIDVTGASSYHGFLPVLVRTCITTLTSPQPDGQPFPLALATALFSFLYHLASYEAGGEALVSCGMMESLLKVINWPGSELEHITFVTRAVRVIDLITNIDMQGFQAHGGLSSFINRLDMEVNICRKVQPFEIDPSMYNQDVSVPTREKLNDNSDEAGPSRTSNEVFDEREETCNPMEFSEDENTNSKTETKIEQNSSSNSSPIRSGKTCLPQRAALLKSMFNFLKKAIQDPAFSDSIRHVMEGELPSSLKHIISNSEYYGPSLFLLAIDVVTVYVFQEPSLLSSLQDNGLTDVVLHALLIKDVPATREVLGSLPNVFSALCLNQRGLESFMKRRPFERIFKVLISPNYLSAMRRRRSADPLGDTASNLGNAMDELMRHQPSLKTDATAAIIKLLEELCVLGCDPRYICWRAASKADNSPSSSSSNTRQSSGQSVGVGVGDNGAGSGGAGGSSSDEEEEDEEEASTSSHPQREEQPSPSPVQPGPPPQQPREKTPIALVDYIHNVMKFVDAILSNNSTDDHCREFVSQKGLVPLLSILGLPNLPVDYPVAQPAQSVASVCKSILNLAHEPLVLKTGLLQLNEVLCLLKPLHSHMESPGGSVLLHELASAPNLETAFTSDTATPLLHAMNAAHSYVVMFVHVCRTSQSEIRNLSMNHWGSELGLAVLQGLSELYMSLVWESTLLLALCSDDSIPAGCDFGKEDMDKLIPAELKTDGDTSIWPSASAASDMGSNGMTTAMEALSTDPPPVSMEVDDSKPNTSTGRASPSPHQLKYIKPLLGASSRLGRALAELFGLLVKLCMGSPIRQRRGQQLPMMPTIPNSAARGVACALNILLTRGLSWDKLPPSPLPKFKLTFLICSLGFTSPMLFDEKRHPYHLMLQKFVQLGGQNAFFSTFRWALSGGEQFSLSEGLEHPDLPDGTGEFLDAWLMLLEKMVNPKAILDSPHVGLAKCTGFNNTYRSQDPIIKYLQDIHKKAFEAVMLMWGKKPLKNYGARMTESILSILRHILRGEKLIKERTEEETTEDTSTTSTSGTAAAVSRAGSNNATTERRDDPEADVNAEHLRQLMDMGFSRAHCVEALLHTLSVEQATDYLLSNPATQRRPDVSVGDVSGQGPIMDLDFTDDQVMYAIAMSLGDSDTRKSTEEPRDVPITQTIDEFTGTALEQCLNLLDLMPDTVYRICDLLVTITKRNGEEWRDTMLRHLIRDIGELVDYLIDVAESAEEDAGVRLVECEQATKVAGRIYLYTLFFEGTFQEMRVPCAQIVEESGILNKLVDLLVASEGPLTSHKVKLTKECKDGQMPVIKTPKWLAPLLLLIDRLEKVAVLTQRKQLMHKVTNKVWKWFDLSSGKWTAYSPLNNRLINDAYWAGEPSVRINCSRRRYLITFSCMTQVNEDSDNRRPITMDFKFQNASSDDASSGSDSNMDTEETPSEEKRNNTVVQGLNPIAAPTIVSTCVKLLAIPVDRDTLHALMKVCLRLTRDYNNAQVFAKEGGVKLLLEMTQASSFIGCISLSTLLIRHTLEEPQTLRLAMEKVVRSRTQTNIPPAYKEILFMTRQISSAVCRNPEVYREVCDDILRVDISVLKKDDTDNRLVVKALPSNHSSATPMVEEISISVVHDLLNALIKPVPVFPDDNTATPTGTPEKKSTNLTTIAATAHGVSATSSRRTDGTRNNASTANGPLDDDDQIVPLKMYTDYMSNGKVEPEEAKKPLLSKSAILKMLAESIRSYGAVANLIAEHTYRANQSEMVSEEITALGFLLDKLLPILPENSGDRQCSSMARMLIAAIASCNHSPDAQTTLVTEVKAALLRTLTLPESSEKHAQLQLIIGLISTMIDSCPPTSHTPLRVPSKVHQYNNVNYIVRIMLKKGIITDLAKIPHSLDLSSPNMAGTINAALKPLETLSRIINQPMPGTVNNKFPKPKNRTVQDEPIGDQTGTTTSEATHAVGEETNEDAENTEHDISLNAESLEPTSESQVHEEGDEAALEDIMDQLLERDGSAVTEEPTSRSHRPMDIDDESLAMRDTDGDFDPTRDTTVRVTSRSVYMTITTYFKNQKSILKNIVYSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HG29</accession>
    <name>A0A8J2HG29_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Similar to SMN1: Survival motor neuron protein (Bos taurus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HICCMSTLAB_LOCUS9101</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Myofibril</location>
            <location evidence="1">Sarcomere</location>
            <location evidence="1">Z line</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Cajal body</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Nucleus</location>
            <location evidence="7">Gem</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SMN family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5099523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HG29"/>
    <dbReference type="OrthoDB" id="197400at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015030">
        <property type="term" value="C:Cajal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097504">
        <property type="term" value="C:Gemini of Cajal bodies"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030018">
        <property type="term" value="C:Z disc"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd22852">
        <property type="entry name" value="SMN_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22851">
        <property type="entry name" value="SMN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21182">
        <property type="entry name" value="Tudor_SMN_SPF30-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040424">
        <property type="entry name" value="Smn1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047313">
        <property type="entry name" value="SMN_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049481">
        <property type="entry name" value="SMN_G2-BD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010304">
        <property type="entry name" value="SMN_Tudor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002999">
        <property type="entry name" value="Tudor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39267:SF1">
        <property type="entry name" value="SURVIVAL MOTOR NEURON PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39267">
        <property type="entry name" value="SURVIVAL MOTOR NEURON-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20636">
        <property type="entry name" value="SMN_G2-BD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06003">
        <property type="entry name" value="SMN_Tudor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20635">
        <property type="entry name" value="SMN_YG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00333">
        <property type="entry name" value="TUDOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63748">
        <property type="entry name" value="Tudor/PWWP/MBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50304">
        <property type="entry name" value="TUDOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tudor" evidence="9">
        <location>
            <begin position="64"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="174"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="177"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00034695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAG5099523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="243" mass="27465" checksum="5168EE3D5FD33519" modified="2022-05-25" version="1">MSESDKELFVRSKHIDINKDDDVWDDSVLIKAYDRAISLAKEEVAKGLSNETNTYQKKIAGSNKWTVGSQCRAIYSVDGQLYEATILKIFKDGKTCLVKFLGYGNTEKVELSSLYESEGVSMYESGGMEAQKNYDQMSTSDSASCSNIRYSESNYEQGRNRFKEERMTFETADHHQQPNFPSSSMSFEGIPPPPPIPSQLMDRLPKNETDALSSMLMSWYISGFHTGYYHGIKQAQKSKKNDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HGG4</accession>
    <name>A0A8J2HGG4_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Alpha-1,3/1,6-mannosyltransferase ALG2</fullName>
            <ecNumber evidence="10">2.4.1.132</ecNumber>
            <ecNumber evidence="10">2.4.1.257</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">GDP-Man:Man(1)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HICCMSTLAB_LOCUS9518</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Mannosylates Man(2)GlcNAc(2)-dolichol diphosphate and Man(1)GlcNAc(2)-dolichol diphosphate to form Man(3)GlcNAc(2)-dolichol diphosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 10">
            <text>a beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + GDP-alpha-D-mannose = an alpha-D-Man-(1-&gt;3)-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + GDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:29515"/>
            <dbReference type="Rhea" id="RHEA-COMP:19511"/>
            <dbReference type="Rhea" id="RHEA-COMP:19513"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57527"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:58472"/>
            <dbReference type="ChEBI" id="CHEBI:132510"/>
            <dbReference type="EC" id="2.4.1.132"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8 10">
            <dbReference type="Rhea" id="RHEA:29516"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>an alpha-D-Man-(1-&gt;3)-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + GDP-alpha-D-mannose = an alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + GDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:29519"/>
            <dbReference type="Rhea" id="RHEA-COMP:19513"/>
            <dbReference type="Rhea" id="RHEA-COMP:19515"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57527"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:132510"/>
            <dbReference type="ChEBI" id="CHEBI:132511"/>
            <dbReference type="EC" id="2.4.1.257"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9 10">
            <dbReference type="Rhea" id="RHEA:29520"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 10">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Endoplasmic reticulum membrane</location>
            <topology evidence="10">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the glycosyltransferase group 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.132" evidence="10"/>
    <dbReference type="EC" id="2.4.1.257" evidence="10"/>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5100367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HGG4"/>
    <dbReference type="OrthoDB" id="448893at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004378">
        <property type="term" value="F:GDP-Man:Man(1)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102704">
        <property type="term" value="F:GDP-Man:Man(2)GlcNAc(2)-PP-Dol alpha-1,6-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03805">
        <property type="entry name" value="GT4_ALG2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027054">
        <property type="entry name" value="ALG2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45918">
        <property type="entry name" value="ALPHA-1,3/1,6-MANNOSYLTRANSFERASE ALG2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45918:SF1">
        <property type="entry name" value="ALPHA-1,3_1,6-MANNOSYLTRANSFERASE ALG2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="2 10" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Glycosyltransferase subfamily 4-like N-terminal" evidence="12">
        <location>
            <begin position="13"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl transferase family 1" evidence="11">
        <location>
            <begin position="208"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00045103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00045104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU367136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAG5100367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="411" mass="46506" checksum="41A16269C4FB3E54" modified="2022-05-25" version="1">MVKVTFLHPDLGIGGAERLIVDAALALKGFGHDVNIVTTHHDPKRSFAETNNGTLPVTVVGNWIPRHIFGKFYAAFAYIRMIYAALAIYFMSDRPDIIVCDLVSACIPFLRMASDYVIFYCHHPDQLLTQPGGWLKSLYRIPLNYLEEKTTGQADKIFVNSNYTLKVFKQTFKSLDITPEILFPSIHTDFFDAATPQPLKNVFADKLSNLPADRFIILSINRYERKKNILLAIDALATCIEKFKGTENFSNNIYLIIAGGYDERVNENVTYYQELYDYATKLNIIDRVIFLKSPKDSEKISLLNNCDVLIYTPENEHFGIVPLEAMYLRKPVIAHNSGGPMETIVNGVTGYLVDGQDIVEGFANKIADLIKDSEMRKRFGNAGRQRVIESFSFTAFGIQLDQVVNDLTKRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HHY3</accession>
    <name>A0A8J2HHY3_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Similar to FAM210A: Protein FAM210A (Gallus gallus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HICCMSTLAB_LOCUS10499</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5101597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HHY3"/>
    <dbReference type="OrthoDB" id="5874039at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045866">
        <property type="entry name" value="FAM210A/B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009688">
        <property type="entry name" value="FAM210A/B-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21377:SF1">
        <property type="entry name" value="PROTEIN FAM210A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21377">
        <property type="entry name" value="PROTEIN FAM210B, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06916">
        <property type="entry name" value="FAM210A-B_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="116"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1279" evidence="7">
        <location>
            <begin position="107"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF06916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG5101597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="196" mass="22640" checksum="D9DFE8C59A56BA27" modified="2022-05-25" version="1">MEVMIRRTSVINNLLIKSYFNLRSLSNYRVCACYSNFNFSNHDTTRNRASNENFSSNLLTNINPVIYNKQLLQKFSNASVEDKKKDEQVDTSNESPLEKFKKLNVFQKMKQLFKDYWYIMAPVHIATSTVWVVIFYTAAKNGVDVIPIMEYFMIPDKYIDLIRNSGAGHWAAASSSKCSIAFKKKTDSVDSKINRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HHZ0</accession>
    <name>A0A8J2HHZ0_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to TP53BP1: TP53-binding protein 1 (Homo sapiens)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS10514</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5101612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HHZ0"/>
    <dbReference type="OrthoDB" id="129353at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000077">
        <property type="term" value="P:DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17724">
        <property type="entry name" value="BRCT_p53bp1_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047250">
        <property type="entry name" value="BRCT_p53bp1-like_rpt2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047252">
        <property type="entry name" value="TP53BP1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15321:SF3">
        <property type="entry name" value="TP53-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15321">
        <property type="entry name" value="TUMOR SUPPRESSOR P53-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18428">
        <property type="entry name" value="BRCT_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63748">
        <property type="entry name" value="Tudor/PWWP/MBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BRCT" evidence="2">
        <location>
            <begin position="1029"/>
            <end position="1119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="261"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="404"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="458"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="531"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="780"/>
            <end position="881"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="167"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="287"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="426"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="458"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="531"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="561"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="597"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="619"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="800"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="815"/>
            <end position="832"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5101612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="1139" mass="124936" checksum="FCF4A813D0B34FDA" modified="2022-05-25" version="1">MSEPVKTAMETSADNKSVETEDAENVLANASTKVNDSQSFTLTDFDCSQQSLIADSELKDKEELPAKAREHDAVQDGGAAEDSGAKTPGITEDNNKDNKNEKIEKIEKMEEEILETPTDERVSPLKRPMAKRNGSEEPVAKVQKIESDAAPESLDCENSLGDQISEEDNKAKAKAKEKIGDANENTVKALEEVLEKDIADNGETLQELSQALESVLEDKKLEEDEAKDTVPSELIAKSSVEVSKKSRQSIEVIFDKSLAPTKPKEVVELDEDGEKIVLDSSQEDEASQGSDSNTIVNKSKISNGTNSTKSSESDRTASVPSDLSDESVKVDIIVKDNVPVVTLPSDNEADISIDVKKIKTVEKEFTVIVKVKCLLHVDSQNYKECVSKEVTSVYCDNYGEHHLPPSRINSDISNMADVSASDTKDPTSPSSVTSNTQLPYALPGSRHSIISTISSSSSSSYASSVKSNESSTKLNPFSLPRGFAKHAKKGDMNTIDESSESPKHVGWRNVDLITTSVVDHLNHEIAINDLSAHNGSSNDIGSLTRITSSTPETKVLSTPKSSKKGKVVKRTKTRSTRSRANGATKAAAEEAIYLQEEGQKRQKEKEKEKEKEKEKDKINSNVSTPSRASSRSLSILRNQAPVSDEESDSRIGKICFAKWSDGTFYPATIVSKNKTKLKVVFFDEKSKVVAENFVYVVMDTLSPNTLVHAMVVDKKEKYDTAGVIQRVEKIDDEIWYHVDTEDKGRVRNTTKDLFLTPDQFKILKETELVNPEATPHFEKITLDNVIEGSRRQKTSPSALRSRGQSQSTSGSKPSISEKKSFDTSDSDAKNEDVTELGEINPEIAGISSASTSKGPSSRIKGKGKSKKKADDDDETINKFGPIPPAGSTLFKGMNFILTCAPLESIDAIKQANPVSSEYSEEETDYEREWSSIPFLRERLVDQITAGGGHVYNSFDEIPPAEYKKTKLITNVPNITATSLLCLSVGIMPYNHQWIITSCIANKLGSPEASELPAGYSIRLGDYIKNLERQGNMPFEHLKVVIPKISVSESSVDFWKRVIENAGGVVQLIESPKDEFFDATVVVTNQNCPGWVEDKAANYDVPLVSTTWVVQCIIEGATVPGLEERCKHKKQITETSTNSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HI25</accession>
    <name>A0A8J2HI25_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Similar to Tret1: Facilitated trehalose transporter Tret1 (Bombyx mori)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HICCMSTLAB_LOCUS9831</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5100758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HI25"/>
    <dbReference type="OrthoDB" id="8120565at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000218">
        <property type="entry name" value="facilitated trehalose transporter Tret1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050549">
        <property type="entry name" value="MFS_Trehalose_Transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48021">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48021:SF1">
        <property type="entry name" value="GH07001P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="94"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="118"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="151"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="178"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="258"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="297"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="323"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="357"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="394"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="425"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="22"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAG5100758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="466" mass="51267" checksum="53D1A7827661B441" modified="2022-05-25" version="1">MTQIIVELPSIPKKILWPQWLTGITISLAVLTSGLSSGWTSPYLAKFTSPDMNTSINLSETEASWVASLLNLGRFGGSIVGATSQGIIGRKKTLLISTVPMAIGWTCTIIANSVTWLYVARCFCGIAGGMMWTTLSLFIGEVSDSSIRGSLVFLNSNAAFVGAFLGNIIGAHLPFEQFGYVSLSLNALFFIIFCFIPDSPYHYVTKGDLKSAEASLKWFKREANVLKEIQELKNFIGNTETNLLTQLREFKKPQNRKNVIIMGSLNVFLYFCGHNTMNYYAEIIVTKSKVNFSPSTIVIALSLCTIIACSSAAMVVDRFGRRFLLIASSLGTALSLALLGLHFHLLSLHIESTPFTWLPIASLFLYNFSISHGLIPVPNALISELFPPNIKTMASLFFSGSSALLSFATTKTFQPLINIMSEKYVFWIFALSAFSAAPFTYAYITETKGQTLVEIQINADQNQKKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HJ94</accession>
    <name>A0A8J2HJ94_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS8919</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5097871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HJ94"/>
    <dbReference type="OrthoDB" id="7700380at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5097871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="85" mass="10036" checksum="FB2ACCE1B585D8EC" modified="2022-05-25" version="1">MRFFWTKSKQLQTIKTSYIPVHSRYENASVKLKWKNKRSKLFEVLDAKILKISDDKDLLENISVDENTGRILDVTTKAFLRTVFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HJJ2</accession>
    <name>A0A8J2HJJ2_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Similar to Sv2b: Synaptic vesicle glycoprotein 2B (Mus musculus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HICCMSTLAB_LOCUS9085</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5099480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HJJ2"/>
    <dbReference type="OrthoDB" id="3936150at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23511">
        <property type="entry name" value="SYNAPTIC VESICLE GLYCOPROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23511:SF34">
        <property type="entry name" value="SYNAPTIC VESICLE GLYCOPROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="106"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="135"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="164"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="200"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="316"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="390"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="420"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="446"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="479"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="508"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="67"/>
            <end position="532"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAG5099480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="536" mass="58842" checksum="CD36E3AB6FED72F8" modified="2022-05-25" version="1">MVEGEPHSKPNNKCDVKDNRLNGCGSKDLELAGIGSKGKSLDPEKGSYIKADFEKAIELTEYGKFHYFLLAVCGFVSTSEEMDVISMSFILPSAQCDLNLSTAAKGWLSSIIFIGMMAGAYAWGSVADALGRRKVLIVISFMNALCIVASKFQPKSKRGSMLSFMAAFWTLGNLFVAGLAWLIIPHDIGITSTSFTFNSWRIFLLICAAPSFIVAGLLLLLPESPKYLLSRGRYDEALNIFRNIYAINTGKPRESYTVKELILDDFANSKNIVEPIKSTGGTIGGTKDNNNKKKNKYKIMFGDIMDNSKQLFVSPILRFTVISIIINFTFHIGYYGLMMWFPELFNRFDLFNQRNPNQNTDICQVTEFYIKVKNNITEQDQPCDSKIGEAVFIESLITVASAIPANILAVLGMDRLGRKFFLVFSTLSSGACSVGLYFVYNKVHNVIVSAFFSGVISCGNAALDCLITEVFPTNLRATGIAISMVAARLGGIIGNIVIAQLLDMYCPAPTFIVAALLIGGGLLSLFLPNTTREPLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HK00</accession>
    <name>A0A8J2HK00_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS11670</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5103759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HK00"/>
    <dbReference type="OrthoDB" id="6380971at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.15.10.30">
        <property type="entry name" value="Haemolymph juvenile hormone binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010562">
        <property type="entry name" value="Haemolymph_juvenile_hormone-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038606">
        <property type="entry name" value="To_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11008">
        <property type="entry name" value="PROTEIN TAKEOUT-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11008:SF9">
        <property type="entry name" value="PROTEIN TAKEOUT-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06585">
        <property type="entry name" value="JHBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5103759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="189" mass="21522" checksum="E1D069594ADA96A8" modified="2022-05-25" version="1">MDFQSSMSRYLSPCNCTIFMWKLTTRKSAIDRARLSLLGPTIAVNLTIPTVIVDGYYNISGILGDTFELHGSGPFAATARDFKVFFMTVLGYSRGMYLKSFDLDFSIRDVKIRMVNFMGNSKYSSVMNEVFQELTPQGIEIIKPEILPDIQDFIAARVNDTIYHLTMRDILTFLIGENEIRNNPHLLQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HKG4</accession>
    <name>A0A8J2HKG4_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to Drg2: Developmentally-regulated GTP-binding protein 2 (Mus musculus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS10231</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5101158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HKG4"/>
    <dbReference type="OrthoDB" id="603at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045001">
        <property type="entry name" value="DRG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031167">
        <property type="entry name" value="G_OBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43127">
        <property type="entry name" value="DEVELOPMENTALLY-REGULATED GTP-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51710">
        <property type="entry name" value="G_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OBG-type G" evidence="2">
        <location>
            <begin position="63"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5101158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="150" mass="16698" checksum="1B1E30D0D6B71307" modified="2022-05-25" version="1">MGILEKIGEIEREIARTQKNKATEYHLGLLKAKLAKYRSQLLEPTSKKSEKGEGFDVLKSGDARVALIGFPSVGKSTLLNTLTHTQSEAASYEFTTLTCIPGVIEYKGANIQLLDLPGIIEGAAQVSLTIYLFVINLFIYYKIYLFNYDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HLB6</accession>
    <name>A0A8J2HLB6_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Similar to cwo: Transcription factor cwo (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HICCMSTLAB_LOCUS10924</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5102256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HLB6"/>
    <dbReference type="OrthoDB" id="6371181at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11440">
        <property type="entry name" value="bHLH-O_Cwo_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.280.10:FF:000079">
        <property type="entry name" value="CLUMA_CG001539, isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.980">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050370">
        <property type="entry name" value="HES_HEY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003650">
        <property type="entry name" value="Orange_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10985">
        <property type="entry name" value="BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTOR, HES-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07527">
        <property type="entry name" value="Hairy_orange"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00511">
        <property type="entry name" value="ORANGE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158457">
        <property type="entry name" value="Orange domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51054">
        <property type="entry name" value="ORANGE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="7">
        <location>
            <begin position="67"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="Orange" evidence="8">
        <location>
            <begin position="161"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="231"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="246"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="277"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAG5102256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="389" mass="43492" checksum="7C4DA5F837531C66" modified="2022-05-25" version="1">MMDTQNYWDESSTHSMQVKYESSLEGRSCKDEIYRMGIGAGYCEGNLNFTTASEDDEVYTKKKVSRQDPMSHRIIEKRRRDRMNNCLADLSRLIPTEYLKKGRGRVEKTEIIEMAIRHMKYLQGAHQDTKHPSVTNIHNHQEDSVDSVSHSASGSIAAEHYRMGFQECLSEAVHFLVEGEGFFARDSLCVQLINHLQQHCEKIVATSDRLGFPHPEMPTLNDTGASSFVDASIPTLCPPTNHSDRGSSSGISSLSDSERPQQIIPPPTMASDDSNHSSHSNNASSSVPRPSNYKFKSSIKQRFSAERIKSSPLAPSEKSHGVPIFALHEGGAFYIPLTIDSGFIRPQMSYITDTGPDIVLHPVTISVNFNQASNPTWSPQYSPRHQDHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HLE4</accession>
    <name>A0A8J2HLE4_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS8094</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5096207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HLE4"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5096207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="75" mass="8626" checksum="450A9DE018AB5CAE" modified="2022-05-25" version="1">MSSDTSYSDLDSHENSPIANLNTIKRHNLVVVISLFVTQIDIVIKKMKNKKKPFAHTVILELRSRLNSIKNIFFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HLZ9</accession>
    <name>A0A8J2HLZ9_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Glycerol-3-phosphate dehydrogenase</fullName>
            <ecNumber evidence="13">1.1.5.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">HICCMSTLAB_LOCUS12395</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>a quinone + sn-glycerol 3-phosphate = dihydroxyacetone phosphate + a quinol</text>
            <dbReference type="Rhea" id="RHEA:18977"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:57597"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="1.1.5.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Polyol metabolism; glycerol degradation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 13">Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.5.3" evidence="13"/>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5106709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HLZ9"/>
    <dbReference type="OrthoDB" id="264015at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004368">
        <property type="term" value="F:glycerol-3-phosphate dehydrogenase (quinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006072">
        <property type="term" value="P:glycerol-3-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.870:FF:000001">
        <property type="entry name" value="Glycerol-3-phosphate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.9.10:FF:000037">
        <property type="entry name" value="Glycerol-3-phosphate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.870">
        <property type="entry name" value="Alpha-glycerophosphate oxidase, cap domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031656">
        <property type="entry name" value="DAO_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038299">
        <property type="entry name" value="DAO_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000447">
        <property type="entry name" value="G3P_DH_FAD-dep"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11985">
        <property type="entry name" value="GLYCEROL-3-PHOSPHATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11985:SF15">
        <property type="entry name" value="GLYCEROL-3-PHOSPHATE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16901">
        <property type="entry name" value="DAO_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01001">
        <property type="entry name" value="FADG3PDH"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00977">
        <property type="entry name" value="FAD_G3PDH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00978">
        <property type="entry name" value="FAD_G3PDH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0106">Calcium</keyword>
    <keyword evidence="8" id="KW-0274">FAD</keyword>
    <keyword evidence="5 13" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="14" id="KW-0732">Signal</keyword>
    <keyword evidence="10" id="KW-0809">Transit peptide</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035176560" description="Glycerol-3-phosphate dehydrogenase" evidence="14">
        <location>
            <begin position="17"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="15">
        <location>
            <begin position="611"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="15">
        <location>
            <begin position="681"/>
            <end position="716"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU361217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CAG5106709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="752" mass="83785" checksum="27121DAA68AB068D" modified="2022-05-25" version="1">MASLRLLAAGASAVGAGVLSSYYLTSDSPVLAEKVHKPIKRQLPTREDQVKTLKTQDEYDVLIIGGGATGAGCALDACTRGLKTALIEGDDFASGTSSRSTKLIHGGVRYLQKAIMQADVEQYKMVKEALHERAQMLHSAPHLAHPLPIMLPVYTWWQIPYYWFGIKMYDLVAGSKTVKSSYYLSKSNALELFPMLKGDKLTGAIVYYDGQQDDARMNLAVALTASRLGATVVNHVKVLNLLKGLDKDGKRVLVGARVRDEMTGEEWDVKAKAIINATGPFTDSIRKMDDQSVPEICCPSSGVHIVLPGYYSPDQMGLLDPATSDGRVIFFLPWQKQTIAGTTDLPCQVTHNPKPTEDEIMFILQEVKNYLNPDVEVRRGDVLSAWSGIRPLVSDPNKPNTQSLARNHIVHVSPTNLITIAGGKWTTYRAMAQEAVDAAIDACQLEPTAECQTDGMLLEGAHGWSPTMYIRLVQDFGLECEVAQHLAKSYGDRAFPVAKMASLTGKRWPIIGKKIHPEFPYIDAEIRYGCREYARTAIDMIARRLRLAFLNVQAAQEALPGIIDIMAEELKWSADEKKKQQQQASDFLANEMGQMVNRASRDKIPINLTKDEIQLYIKRFQIIDKDRKGYVSINDIRRGLKALGIVLHQDEMHLLLSEIDLSYNGQMELQDYLQLFGDKDVPGEELHEILREIDTNMNGQVELDEYLQMMSAIKSGHVAYSRFARMAEMEEAQHEKDVLKKKISVERSGGGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HMT2</accession>
    <name>A0A8J2HMT2_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">[histone H3]-trimethyl-L-lysine(9) demethylase</fullName>
            <ecNumber evidence="3">1.14.11.66</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">HICCMSTLAB_LOCUS11879</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>N(6),N(6),N(6)-trimethyl-L-lysyl(9)-[histone H3] + 2 2-oxoglutarate + 2 O2 = N(6)-methyl-L-lysyl(9)-[histone H3] + 2 formaldehyde + 2 succinate + 2 CO2</text>
            <dbReference type="Rhea" id="RHEA:60200"/>
            <dbReference type="Rhea" id="RHEA-COMP:15538"/>
            <dbReference type="Rhea" id="RHEA-COMP:15542"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:16842"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:61929"/>
            <dbReference type="ChEBI" id="CHEBI:61961"/>
            <dbReference type="EC" id="1.14.11.66"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the JHDM3 histone demethylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.11.66" evidence="3"/>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5104192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9547406at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051864">
        <property type="term" value="F:histone H3K36 demethylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140684">
        <property type="term" value="F:histone H3K9me2/H3K9me3 demethylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15493">
        <property type="entry name" value="PHD_JMJD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20391">
        <property type="entry name" value="Tudor_JMJD2_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20392">
        <property type="entry name" value="Tudor_JMJD2_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.330.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.650">
        <property type="entry name" value="Cupin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034732">
        <property type="entry name" value="EPHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003347">
        <property type="entry name" value="JmjC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003349">
        <property type="entry name" value="JmjN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040477">
        <property type="entry name" value="KDM4-like_Tudor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002999">
        <property type="entry name" value="Tudor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10694">
        <property type="entry name" value="LYSINE-SPECIFIC DEMETHYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10694:SF129">
        <property type="entry name" value="LYSINE-SPECIFIC DEMETHYLASE 4B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02373">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02375">
        <property type="entry name" value="JmjN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13831">
        <property type="entry name" value="PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18104">
        <property type="entry name" value="Tudor_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13832">
        <property type="entry name" value="zf-HC5HC2H_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00558">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00545">
        <property type="entry name" value="JmjN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00333">
        <property type="entry name" value="TUDOR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63748">
        <property type="entry name" value="Tudor/PWWP/MBT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51805">
        <property type="entry name" value="EPHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51184">
        <property type="entry name" value="JMJC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51183">
        <property type="entry name" value="JMJN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="9" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="11" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="13" id="KW-0804">Transcription</keyword>
    <keyword evidence="12" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="JmjN" evidence="17">
        <location>
            <begin position="11"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="domain" description="JmjC" evidence="18">
        <location>
            <begin position="141"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="19">
        <location>
            <begin position="1372"/>
            <end position="1490"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="426"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="475"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1017"/>
            <end position="1044"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1161"/>
            <end position="1195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="428"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="509"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="16">
        <location>
            <begin position="1023"/>
            <end position="1035"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="1167"/>
            <end position="1176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="16">
        <location>
            <begin position="1178"/>
            <end position="1190"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="20">
        <location>
            <position position="1601"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009711"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="CAG5104192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="1601" mass="179803" checksum="9F861180A2C63343" modified="2022-05-25" version="1" fragment="single">MVSSSGGTPRIQVFRPTYEEFKDFSKYIEYMESKGAHKAGLAKVIPPPEWVPRKGGYDTSKMDLTIPAPICQVVNGKQGLYQQINIQKKAMTIQEYEKLANSERYATPKHFDYEDLERKYWKNITYVAPIYGADVSGSLTDPDVNVWNINHLGTILDYVNKDYGISIDGVNTAYLYFGMWKTTFAWHTEDMDLYSINYLHFGAPKTWYAIPPEHGRRLERLASGFFPSNYQSCPAFLRHKIWVEYGKRATQCTCNNDMVKISMDTFVKRFQPERYDLWLRGEDIGCHPEDPRQTAAPMPSQMDLLCCNSTDKLPDSFINAPKNKRHTIHRKKSLVDSNQDLNMHELVNGPDIPADVKKVLQDLELEEDVPDEQQLEVLEDIWLKAGELEIEEASLYDDGYNKKKNKRKKRRMTVDKERVGIKTKKPVKNTNQNNIETEGNTSTNSEIKPKYLDIIGSAVPCLVLPKITNFDGINSLSDSQSPTKPKEPSETFATPGDTPIKKKRKYTKHKSENKERKKDSEGNDIIPKRTYKKKLKCIAPLSAPESVFDSSQPLDVSDAYVQRKLMAMPSLSSQKSQKTESIKLSNITDQNIDQSIISKPEKPTPLQISENIDACIAAVVSQYQYMSDSSLDEKPSSENDNFAVDKSLISPVDESSIKEPFAIEKKFSAEELINDKSLIKNNSSSQTEFFKFSEFNSGNSEVKKNSFILPKKCSTNINRPLNIYQKNDIIKAPKLCVLTNNCTSQSEAKPTPSQDNDTLKAASGLLVLQQSSRILPKPANESNIFIKNTNNSFLQNSQNILSTKEMQQRLERFKLMNTSINPETNSDNNINVFQSKLCNSFPVSSERISVIEEPKQGQGQLSGVTASEDSRVATKRFWQVPNTNTVLIASDSNINSAASNPKKFWQLPSANIVISDNKSINQFSNTTPLFYSTPNNNGLITLAPKTSARMSLAPSSSLSHQQQQHQKINMGTSILKVSQPGQQNSLNTVEIIMPQPQYQIPQLQKIAPAPAPMILQPAQSIKPKQKRTPRKKKPTKLSIESAESQEIASERKMCSIATQVDNLSPLKLTECTKFTEQSNSPFVKEETAQEYPASFSSSTDNSAAAIKSQMLFSVPSNKYLSMSYADSKPLPDIKPIVPSIGSEIKIPIPTKPSVLHKMNNIKPPVLTKNSGKIQGNKSPRKPRAPKKKSLIKLEDKNPPVLTIEANYPGLSANDSSKVSSSSLSLLSPTLSVSSSSSNSSSQIIPGHILEMLFPNHPDLEKVRTFNDYWSSQASHCAICTGFASSSNKNTRQMPPDWKDCRVISLPERSSIWVSPALFAANSKEQDIEPEKDSLLRCRDCHVVVHASCYGITVLPTDSPNWACDKCKAGMTQSNCCLCPMRGGAVKRTSDGRWAHIFCALLIPGVTFKDSVHKDPINVLTIKHDMVKQQCSYCKQNTGVTCNEHNKSKEELDIRQGDKVWAKHRNKRYYQATVESIDSATFCMVTFSDHSFSNNLYQTDIISHSTIPDIGESCRVKWTDGNVYDAIFEGTNFRTMYTVMFDDGSRFAVKRNQIFALDEDLPNRVQGRLSTATEMQHRSHLYGNESSGYFVVQRKRNKLKLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HMU1</accession>
    <name>A0A8J2HMU1_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Similar to DNA-binding protein P3A2 (Strongylocentrotus purpuratus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HICCMSTLAB_LOCUS12621</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NRF1/Ewg family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5107182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HMU1"/>
    <dbReference type="OrthoDB" id="10031051at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039142">
        <property type="entry name" value="NRF1/Ewg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019525">
        <property type="entry name" value="Nrf1_NLS/DNA-bd_dimer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20338">
        <property type="entry name" value="NUCLEAR RESPIRATORY FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10491">
        <property type="entry name" value="Nrf1_DNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Nuclear respiratory factor 1 NLS/DNA-binding dimerisation" evidence="8">
        <location>
            <begin position="61"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="284"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="19"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="293"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="314"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="325"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF10491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAG5107182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="545" mass="58818" checksum="25C2D5613E7AB615" modified="2022-05-25" version="1">MVSLPSTESVTMERMDRLTDDDDDEPSSGSETYEEGDLLSHALGDDVTAQLAAAGSKNANGPIGVAAAAAIVSAKKRKRPHSFETNPSIRKRQQNRLLRKLRQTIDEFATRVGQQAIVLVATPGKPNSSYKVFGAKPLEDVVKNLRSMIMEELESALAQQAPPPVQDDPSLYELPPLIIDGIPTPVEKMTQAQLRAFIPLMLKYSTGRGKPGWGRESTRPPWWPKELPWANVRMDARSEDEKQKISWTHALRQIVINCYKFHGREDLLPAFNDDDDKSNILVQQTTPHSSHASSSQGQNEQQQQQQTVGVVRLSSTGSSKGNSSPQQILSASPTSLATATQQMTTQYPTTVLQTITNQDGTISIVQVDPSNPTIQLPDGTIAQVQGVATIHTSQGDVQTLTEVGGAEGSVSVDINSVTEATLGQDGQIILTGEDGHGYPVSVSGVITVPVSASMYQTMVANIQSDGTVQMVTPMVQVPKVEPGNGETIEAVTIQGHPMTMINANGEHQVLQVISLKDANALTKAMQGEVIKDEDSQQHQTVSSPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HMX5</accession>
    <name>A0A8J2HMX5_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS11265</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5102950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HMX5"/>
    <dbReference type="OrthoDB" id="10562132at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="138"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="203"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5102950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="372" mass="42793" checksum="391912EA0C0D6A0B" modified="2022-05-25" version="1">MPFFDLQCLKQHKPVTTEILRIYISLLRMDKYSLVTDIRRNKSYIVSSSSIYRLNEENQLTPIKGTEDIDDDCSLFVRDQRVNLGNAPVKFVDSDDDPHKLMKRNSTTSRIIMTKIPKYSPTIKSNVPFKPKVIMANDHEKSKKTVQKQSSEFYGDMVPQYNAREDVGGINSEEGQSPMENIDDSSEPASTLSDKNVIKKKPFQNTPERSKNVSSNPSRSRKSRTIIRRPFASLNTNLRTLHQKINNFSRLIQKTPKQVSVNPQQPSQQLGHYQQPTFSIPKLTESILIENEEEFVVIGDTAISAENLAAILKKSTMRQRFKALKNLCLYLQKKRELTWIPGSKDDLTIYLKSWIGAFLNEHRRELKKNGTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HNF0</accession>
    <name>A0A8J2HNF0_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Palmitoyltransferase</fullName>
            <ecNumber evidence="7">2.3.1.225</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HICCMSTLAB_LOCUS10991</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:36683"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="2.3.1.225"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="7">The DHHC domain is required for palmitoyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the DHHC palmitoyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.225" evidence="7"/>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5102390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HNF0"/>
    <dbReference type="OrthoDB" id="302728at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006612">
        <property type="term" value="P:protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001594">
        <property type="entry name" value="Palmitoyltrfase_DHHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039859">
        <property type="entry name" value="PFA4/ZDH16/20/ERF2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22883:SF452">
        <property type="entry name" value="PALMITOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22883">
        <property type="entry name" value="ZINC FINGER DHHC DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01529">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50216">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="9"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="137"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="172"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="198"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="Palmitoyltransferase DHHC" evidence="8">
        <location>
            <begin position="93"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU079119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAG5102390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="236" mass="27395" checksum="131F59BA116F3146" modified="2022-05-25" version="1">MEKSKLYKLAFKICPPIALIFSILVTITTLYINEGLSPLFIFISIQVYLNWFAIYTISQGETTARRQTRDESDSDSVAITIAQESPANVKYWYCDKCQNYTYKPTQHCVVCNKCFHYRDHHCFFIGGCIIQQNMGNFILICFHTSLACLYSLVVIGPYLYENLRDILEQDPSVVNVIINFCFPIAIARLFIFGKTSYLLLITLFDTLFSVWIVCLVYGAWKLFNCYTGRQRYYPHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HNF7</accession>
    <name>A0A8J2HNF7_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS10928</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5102264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HNF7"/>
    <dbReference type="OrthoDB" id="10333183at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032062">
        <property type="entry name" value="DUF4803"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47890">
        <property type="entry name" value="LD24308P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47890:SF1">
        <property type="entry name" value="LD24308P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16061">
        <property type="entry name" value="DUF4803"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5102264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="378" mass="43633" checksum="7C263620D34E23ED" modified="2022-05-25" version="1">MSNNLRGWESEINLRKNQTKNCKVLASAEAEQVPTFENTYIELIRMIQTIIIDEKNLTSTRSCNSGCNLERIANDISNETECQEFLDCKELSAYYYVFEMDNDVRRYEWFEDSYGHTYGNKNDDTCHGNVKLLSSYFEGPFLDYCVYCVCTCKSKPKRALNILQAEVLPHGKTINATWKPVENFYYNETIKNYYIINDDKSSIELRSGIDYGEANIMNLNDVMCSKDEVVTGVRMRFARDSLDTSNSTEAAMELQIQTTRLDFNTGKLMVDIDEPHYLDNSEKSIDQVCIFLIEFVLRNRGNPRNSPETDFVLTTNKSVKFYRSDLKKDAGQTTVPFFDSREVLFDEGFPLEGIGLFHRSDKESGGSFALRIFDFNMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HNI1</accession>
    <name>A0A8J2HNI1_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Similar to RhoGAP100F: Rho GTPase-activating protein 100F (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HICCMSTLAB_LOCUS10973</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5102354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="120383at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097060">
        <property type="term" value="C:synaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030030">
        <property type="term" value="P:cell projection organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046578">
        <property type="term" value="P:regulation of Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00030">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06718">
        <property type="entry name" value="PDZ_Par6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.555.10:FF:000031">
        <property type="entry name" value="rho GTPase-activating protein 100F isoform X6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052118">
        <property type="entry name" value="Rho-GAP_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057459">
        <property type="entry name" value="SYDE1/2_C2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46150">
        <property type="entry name" value="RHO GTPASE-ACTIVATING PROTEIN 100F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46150:SF3">
        <property type="entry name" value="RHO GTPASE-ACTIVATING PROTEIN 100F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25336">
        <property type="entry name" value="C2_SYDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDZ" evidence="4">
        <location>
            <begin position="226"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="3">
        <location>
            <begin position="849"/>
            <end position="987"/>
        </location>
    </feature>
    <feature type="domain" description="Rho-GAP" evidence="5">
        <location>
            <begin position="1029"/>
            <end position="1236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="70"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="334"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="463"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="528"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="599"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="753"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1299"/>
            <end position="1358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1392"/>
            <end position="1442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="334"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="372"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="463"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="528"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="599"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1335"/>
            <end position="1355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1402"/>
            <end position="1418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1419"/>
            <end position="1436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAG5102354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="1442" mass="159812" checksum="6545411A3629D66D" modified="2022-05-25" version="1">MQWRKHVRIKYGGRVGVGQGQQEEDQVQVHEVQLQGERCARLNYVYHQPRRCNISPTIMLCCGRRKEGRGEVNDISASPGRQAPTTQLRPKDPPAMVIQGDFRKVSGISTEIFKQIETVENDHDASTAAALEVVERRGEMVVRTIEPRQMGRQAAEAAKKLTAFQDSKHLIHFVEIIKRPGQTLGLYIREGNGIDRNDGVFISRIAMESAVYNSGCLKDSKHLIHFVEIIKRPGQTLGLYIREGNGIDRNDGVFISRIAMESAVYNSGCLKVGDEILAVNLVDVTHMSLDDVVIIMSIPRRLVLATRHGPHQTIAQTRQNEHRPPPVVVIKRELNEDESDHITSNHIRDNNRRRGDGREMLPSRSRLGLNGLESNQDINTSNGDLYYNSRPEGHWSYQPPPPPIITHQPKPSTTQHFQPYERGYPKTLESLAEKVHSFYTSPMMPNGNRRMSASGGIQSTANTTRLSGQSQGYGYSQHTPSGRIMPRSGSDQHLTRVDYSNISTPARHTLLRSNLKSGSSTLRYNTRYGTQADTSSTSQRSQNQFGILTRRHRPSIDYASDTEATCSNSPRSTYYYYRQNMKDQSQSNAVSHLATMSRTQIGQSSGGLRSNSLPRSGRSLPQQPSLRTGLTTVASGLIDQEDSDGALSAPELPSFRRDRGRIPSSPSVFTSDEYRAWLSRTPSTSALYEQIRATTSRPPRYTYSAENIHAAVNQKTDLGNYGSYRPLPGTLDRLSTRSASAQQVNLANLRASTAVSSTSHRAGPGQRSTSVTPNARSVLTSQKPSLNSVANQRANSVRRIRNLLELEQTRNIPTPTPTRTQDQRLLDINPSEFLKYKIEKPPTVGTPNSTSSLLSSLGESSSSDFASGVSGLLWVHLLAGRGLRSTTSSSAATTPSTPSGQPNITSCGLRDLYCVLECDRVHKARTVVRTGDLMFDWDETFELDLVGNRQLDLLVYSWDPQHRHKLCYKGSVHLATLLKESPIHQLALKVEPRGTIYLRLRYTDAHQTFKRRGLPVISLATRIAPLFGVDLDTVVSRESKTGGVPGGVSTALSVNNNMNIPIIVWRCVEEVERRGLDIIGLYRLCGSATKKRILREAFERNARSVDLSPDNVPDINVITGVLKDYLRELPEPLFTKCLYQMMVDALAVCLPDDPQGNAKLMFSILDCLPKVNKCTLIYLLDHLALVLSQCNKMSPASLAVCFGPVLMLHSDDATHLDFQQPIAVLKYLLEIWPVKSVRKTSSVGSTLPRVTPIIGLTSSTSSSNIISNHHPSLPQLHQLSQHQQNPVYPGALTRTMLPWQPPLSLHHPPTNSNPMGYGLSTRPPLQIKQRQVVVSSPGSPSSEESASPEPNNKNSQNKFNSIMSATKLSTATYNETTPSTTTTTITTTTTTTTINTIRHEQSTPTSSANTEEGNINSSEHQRRIEHDTEASHDDLILKNNKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HNP5</accession>
    <name>A0A8J2HNP5_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similar to PPP1R15A: Protein phosphatase 1 regulatory subunit 15A (Bos taurus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS12349</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5106617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HNP5"/>
    <dbReference type="OrthoDB" id="5976067at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000164">
        <property type="term" value="C:protein phosphatase type 1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019888">
        <property type="term" value="F:protein phosphatase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034976">
        <property type="term" value="P:response to endoplasmic reticulum stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051254">
        <property type="entry name" value="PPP1R15"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16489">
        <property type="entry name" value="GH11727P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16489:SF12">
        <property type="entry name" value="GH11727P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="333"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="340"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5106617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="495" mass="55908" checksum="58FF2CEADE862E6D" modified="2022-05-25" version="1">MECSPRRSRSLTFDVPSLLGSSYPPALNFVETENSAIKNSLLSLGAKCIQSGTNLPPHACSMDDNTEYSKKEASSSGENKINVATSCSRSKKAILDGMMDVFGSVKSFVRKLPNVVSNLNEEFSVTVVSNGDNIPSRDLYVSVPLSSKETIQINTDMDTSMKIDEELSRNSETFKPSRFLSEIFCKPRSNLPHRKFLSADNIHRQTWSEHTKHAEELFVDVAFEAACEESIGNSLFSGNATIGNNNTKILGTQSERMEIDGEDFDLLDLSCPNSVPESKDVEMIQKESLEISISKIENKNSIECKFNSRTREISESSDGSGDSFIVFEKSQDSEYCSTSGDDDDDDDDDDSEDTDEDTDEDSYNKFTVEFNSKSDFRSRRYSESSVDSDSCVDDTDFIMFKDVSPSKCPVEYSALDDSPGERRESKVRFDPKPLIHTMIKWNYAYRAARKGPWEEIARDRERFRNRINLIGRVINPILTAEHRQNIRQIRFDFQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HNR8</accession>
    <name>A0A8J2HNR8_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7027 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS9868</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5100795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HNR8"/>
    <dbReference type="OrthoDB" id="8197395at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054291">
        <property type="entry name" value="DUF7027"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36694:SF11">
        <property type="entry name" value="LP21121P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36694">
        <property type="entry name" value="PASIFLORA 1, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22954">
        <property type="entry name" value="DUF7027"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="120"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="161"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7027" evidence="2">
        <location>
            <begin position="81"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5100795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="228" mass="25819" checksum="CE2F8E21575F67A3" modified="2022-05-25" version="1">MKVGLLKNFLHCFNLKQGTLLIAILQLFISGIIMTFFLLALAHAMDIQEMVARDSEEALEREAMEAISSMHQNTKRMDIAHHNATEKVYSMYCGLVISVIHFISTILLLYGILINNRHFMAPWMMVMMTTIVALFLSLFLVQQDCPFIAILGGKADMTERIVVLFLIAICLYIWFVVYSTYKSLEIKKGGITHEIHNVKKSKYALTPGEGTSNGKVRLHSGTQIPYEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HPK9</accession>
    <name>A0A8J2HPK9_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">TIL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HICCMSTLAB_LOCUS12487</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the serine protease inhibitor-like (TIL domain-containing) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5106892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HPK9"/>
    <dbReference type="OrthoDB" id="6781148at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030414">
        <property type="term" value="F:peptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19941">
        <property type="entry name" value="TIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036084">
        <property type="entry name" value="Ser_inhib-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051368">
        <property type="entry name" value="SerProtInhib-TIL_Domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002919">
        <property type="entry name" value="TIL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23259:SF70">
        <property type="entry name" value="ACCESSORY GLAND PROTEIN ACP62F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23259">
        <property type="entry name" value="RIDDLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01826">
        <property type="entry name" value="TIL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57567">
        <property type="entry name" value="Serine protease inhibitors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0646">Protease inhibitor</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TIL" evidence="4">
        <location>
            <begin position="8"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="domain" description="TIL" evidence="4">
        <location>
            <begin position="60"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAG5106892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="139" mass="15527" checksum="472CB5F602E9A728" modified="2022-05-25" version="1">MAYSDGGCGPNAEWKSCGSACPPTCESPNRLGVCIAVCVSGCFCKEGYLKESDDVESFGCEEHEHGSICGHYKEPQCYDFVKKPNFIQCINRLYPGCRCDKDYVRNPHSKKCVKKSDCFMSSLRGWRDNIVDSITDQII</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HPV9</accession>
    <name>A0A8J2HPV9_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Pre-mRNA-processing factor 6</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">PRP6 homolog</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">U5 snRNP-associated 102 kDa protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">HICCMSTLAB_LOCUS13348</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Involved in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex, one of the building blocks of the spliceosome. Enhances dihydrotestosterone-induced transactivation activity of AR, as well as dexamethasone-induced transactivation activity of NR3C1, but does not affect estrogen-induced transactivation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5108660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HPV9"/>
    <dbReference type="OrthoDB" id="440128at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000244">
        <property type="term" value="P:spliceosomal tri-snRNP complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000054">
        <property type="entry name" value="Pre-mRNA processing factor 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000058">
        <property type="entry name" value="Pre-mRNA processing factor 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:003529">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003107">
        <property type="entry name" value="HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010491">
        <property type="entry name" value="PRP1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008847">
        <property type="entry name" value="Suf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045075">
        <property type="entry name" value="Syf1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11246">
        <property type="entry name" value="PRE-MRNA SPLICING FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11246:SF1">
        <property type="entry name" value="PRE-MRNA-PROCESSING FACTOR 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06424">
        <property type="entry name" value="PRP1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05843">
        <property type="entry name" value="Suf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13428">
        <property type="entry name" value="TPR_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00386">
        <property type="entry name" value="HAT"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="PRP1 splicing factor N-terminal" evidence="14">
        <location>
            <begin position="21"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="Suppressor of forked" evidence="13">
        <location>
            <begin position="550"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="10">
        <location>
            <begin position="698"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="27"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="108"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="47"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="68"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00031070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00046247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF05843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF06424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CAG5108660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="931" mass="105806" checksum="6AC635BDAD53C420" modified="2022-05-25" version="1">MAVPSASLSTRNKKHFLGVPAPLGYVAGVGRGATGFTTRSDIGPARDANDVSDDRHAPPTKRAKKKEEEEEDEEDLNDSNYDEFSGYGGSLFSKDPYDKDDEEADAIYEAIDKRMDEKRKEYREKRLREELERYRQERPKIQQQFSDLKRELINVSEDEWKNVPEVGDARNRKQRNPRAEKFTPLPDSVLARNLGGESATSIDPSSGLASMMPGVATPGMLTPTGDLDLRKIGQARNTLMNVKLNQVSDSVEGQTVVDPKGYLTDLQSMIPSYGGDINDIKKARLLLKSIRETNPNHPPAWIASARLEEVTGKVQAARNLIMKGCEINPTSEDLWLEAARLQPPDTAKAVIAQSVRHIPTSVRIWIKAADLETETKAKRKVYRKALENIPNSVRLWKAAVELEEPEDARILLSRAVECCPTSVDLWLALARLETYENARKVLNKARENIPTDRQIWTTAAKLEEANGHIQMVDKIIQRAIESLRANGVEINRDHWFKEAIEAEKSGAIHCCQVIIQYVIDCNVEEEDRKHTWMEDAEMCAQQGALACARAVYSHAISHFKSKKSIWLRAAHFERNYGTRETLEDLLQRAVKHCPQNEMLWLMGAKSKWMANDVASAREILSLAFQANPNSEQIWLAAVKLESENAEYERARHILGKARAQCSTRKVVMKSAKLEWCLNNLDKALQLLNEGLKEFDDFPKLWLMKGQIEEQLGQLDKALETYNLAIKKCPQSVPLWRLLADLERRKNHITKARSVLEKARLKNPKNPELWLEAVRNEMKSGGIRDMAYTLMAKALQECPNSGLLWAEAVFMEPRPQRKTKSVDALKKCEHDPHVLLAVSKLFWSEHKLTKCRDWFNRTVKIEPKLGDAWAYFYKFEMANGTPEQQEDVKKRAIAAEPSHGENWCKVSKDIKNWCLSIEQILVIVAKDLPTPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HQ08</accession>
    <name>A0A8J2HQ08_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Proton-coupled zinc antiporter SLC30A9, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">Solute carrier family 30 member 9</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="20">Zinc transporter 9</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">HICCMSTLAB_LOCUS12033</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>Zn(2+)(in) + 2 H(+)(out) = Zn(2+)(out) + 2 H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:72627"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="24">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5104500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HQ08"/>
    <dbReference type="OrthoDB" id="435980at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:monoatomic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006882">
        <property type="term" value="P:intracellular zinc ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006829">
        <property type="term" value="P:zinc ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd21078">
        <property type="entry name" value="NTD_ZNT9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1510.10:FF:000004">
        <property type="entry name" value="zinc transporter 9 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="entry name" value="Cation efflux protein transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.530.10">
        <property type="entry name" value="XPA C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002524">
        <property type="entry name" value="Cation_efflux"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058533">
        <property type="entry name" value="Cation_efflux_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040177">
        <property type="entry name" value="SLC30A9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037129">
        <property type="entry name" value="XPA_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01297">
        <property type="entry name" value="CDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13414">
        <property type="entry name" value="HUEL-CATION TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13414:SF9">
        <property type="entry name" value="PROTON-COUPLED ZINC ANTIPORTER SLC30A9, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="Cation efflux protein transmembrane domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="Putative DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0050">Antiport</keyword>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="13" id="KW-0406">Ion transport</keyword>
    <keyword evidence="15 22" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="17" id="KW-0539">Nucleus</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="16" id="KW-0804">Transcription</keyword>
    <keyword evidence="12" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7 22" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 22" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="10" id="KW-0864">Zinc transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="359"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="390"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="446"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="472"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein transmembrane" evidence="23">
        <location>
            <begin position="289"/>
            <end position="498"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00033405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00034845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00034922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00048349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="Pfam" id="PF01545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="CAG5104500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="616" mass="69380" checksum="3FADEDF52B94E14F" modified="2022-05-25" version="1">MLYRTCNLRNIIGCKLNHYNLDQWYYLQVSLGKRHSSIFFKQSRSRADNYYKLLYNNNYNNLNVCDKKNLDKILKVKQTSTVITRLSSNTNKSSDDDDEIVKLKQELKTTLQNKIVEFKSKEVGIVKERVLESVPSPNDNDNINKMIEGDAGKKAIHPNVIKAKTLRVDLSAESLERNFITPVRAMVDFLLKPSDLESLPKTKRRSPYEDKPPITVYWRKDVEAKAFEVWGSREALMKERIKKEVEHKTYQQNIFTIKRRMKDIRKEVSNEKKIKEREGLLGSSGKVVLTAVIINGSNFLFKLVAWIYTGSHSMFSECIHSAADTFNQLILAYGIHKSVQNPDADHPYGYTNMKHVSSLISGVGIFCVGTGLSIYHGIHGILFPNPVESFYLAYLVLAGSLVSEGATLLVAINSIKKGAEDKNKPFKDYVLMGHDPSVNVVLMEDFAAVIGIGLAGCSMGLTSYLGNPIYDAIGSLLVGGLLGGVASFIIYTNVAALVGRSIPQENLDKINSEIESDVMVRAIYDVKGIDMGNNLVRYKAEIDFDGRELTRAYLDKHDLTAMLEEVKKMSSIDQLEPFLLKHGESIVDMLGGEIDRIELKLKKNHPEIRHCDLEIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HQC7</accession>
    <name>A0A8J2HQC7_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Odorant receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HICCMSTLAB_LOCUS13789</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cell membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the insect chemoreceptor superfamily. Heteromeric odorant receptor channel (TC 1.A.69) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5109153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HQC7"/>
    <dbReference type="OrthoDB" id="7548151at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005549">
        <property type="term" value="F:odorant binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004984">
        <property type="term" value="F:olfactory receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004117">
        <property type="entry name" value="7tm6_olfct_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21137">
        <property type="entry name" value="ODORANT RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21137:SF43">
        <property type="entry name" value="ODORANT RECEPTOR 47A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02949">
        <property type="entry name" value="7tm_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 9" id="KW-0552">Olfaction</keyword>
    <keyword evidence="7 9 10" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="8 9" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="40"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="66"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="136"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="194"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="267"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="298"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="370"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU351113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAG5109153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="392" mass="44743" checksum="4FB59B29761CBBA1" modified="2022-05-25" version="1">MTQDSISSYIEYENFIKLILTMLGLKTSPNDPNTLLQRSILYFQMSMSVLPMIGIFNFLKKYITNVFYLTRGLSIIVSFLTIILKGVCIIVYREDVNELNEILGSSYQKFLSNNKLKKPVLKQVTIFRRLSYTMSIFVAISCLSYIIIPALGMISQAIKGVKPIKYMLPFPAVYGWSIPPNSFRFKLHFLNESLTVLSVICITVGVDNLYTHYIFQMIGLLRAISQRMIGFDEQSKESSAVVVRECMNYYETLIYCKNKLQRIYSPVILWTMSTNAIILCAVIFQLSQMTSISVSRIILFSTYAGAKFSQVFIYAWVSTLLTAESDKCRDAMYAANWVGDKPFMHSVIIMLSQQPLILQACNFTVVSMDVFMSVLNTTISYFLLLNTFAEQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HQN6</accession>
    <name>A0A8J2HQN6_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="30">Diacylglycerol lipase-alpha</fullName>
            <ecNumber evidence="21">3.1.1.116</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="32">Neural stem cell-derived dendrite regulator</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="31">Sn1-specific diacylglycerol lipase alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="36" type="ORF">HICCMSTLAB_LOCUS11337</name>
    </gene>
    <organism evidence="36 37">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="36" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>1,2-di-(9Z-octadecenoyl)-sn-glycerol + H2O = 2-(9Z-octadecenoyl)-glycerol + (9Z)-octadecenoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:38511"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30823"/>
            <dbReference type="ChEBI" id="CHEBI:52333"/>
            <dbReference type="ChEBI" id="CHEBI:73990"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="23">
            <dbReference type="Rhea" id="RHEA:38512"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="26">
            <text>1-(9Z-octadecenoyl)-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + H2O = 2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + (9Z)-octadecenoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:38515"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30823"/>
            <dbReference type="ChEBI" id="CHEBI:52392"/>
            <dbReference type="ChEBI" id="CHEBI:75449"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="26">
            <dbReference type="Rhea" id="RHEA:38516"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="25">
            <text>1-(9Z-octadecenoyl)-2-(9Z,12Z-octadecadienoyl)-sn-glycerol + H2O = 2-(9Z,12Z-octadecadienoyl)-glycerol + (9Z)-octadecenoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:38523"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30823"/>
            <dbReference type="ChEBI" id="CHEBI:75450"/>
            <dbReference type="ChEBI" id="CHEBI:75457"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="25">
            <dbReference type="Rhea" id="RHEA:38524"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="28">
            <text>1-(9Z-octadecenoyl)-2-O-(5Z,8Z,11Z,14Z-eicosatetraenyl)-sn-glycerol + H2O = 2-O-(5Z,8Z,11Z,14Z)-eicosatetraenylglycerol + (9Z)-octadecenoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:38527"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30823"/>
            <dbReference type="ChEBI" id="CHEBI:75913"/>
            <dbReference type="ChEBI" id="CHEBI:75914"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="28">
            <dbReference type="Rhea" id="RHEA:38528"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="24">
            <text>1-(9Z-octadecenoyl)-2-octadecanoyl-sn-glycerol + H2O = 2-octadecanoylglycerol + (9Z)-octadecenoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:38519"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30823"/>
            <dbReference type="ChEBI" id="CHEBI:75448"/>
            <dbReference type="ChEBI" id="CHEBI:75456"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="24">
            <dbReference type="Rhea" id="RHEA:38520"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="27">
            <text>1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + H2O = 2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + octadecanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:38507"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:25629"/>
            <dbReference type="ChEBI" id="CHEBI:52392"/>
            <dbReference type="ChEBI" id="CHEBI:75728"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="27">
            <dbReference type="Rhea" id="RHEA:38508"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>a 1,2-diacyl-sn-glycerol + H2O = a 2-acylglycerol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:33275"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17389"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="EC" id="3.1.1.116"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="20">
            <dbReference type="Rhea" id="RHEA:33276"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="29">Interacts (via C-terminal) with CAMK2A; leading to the phosphorylation and inhibition of DAGLA enzymatic activity. Interacts (via PPXXF motif) with HOMER1 and HOMER2; this interaction is required for DAGLA membrane localization.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell projection</location>
            <location evidence="2">Dendritic spine membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Early endosome membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="22">Postsynaptic density membrane</location>
            <topology evidence="22">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the AB hydrolase superfamily. Lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="36">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.116" evidence="21"/>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5103093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HQN6"/>
    <dbReference type="OrthoDB" id="438440at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032591">
        <property type="term" value="C:dendritic spine membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031901">
        <property type="term" value="C:early endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098839">
        <property type="term" value="C:postsynaptic density membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004465">
        <property type="term" value="F:lipoprotein lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047372">
        <property type="term" value="F:monoacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019369">
        <property type="term" value="P:arachidonate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046340">
        <property type="term" value="P:diacylglycerol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098921">
        <property type="term" value="P:retrograde trans-synaptic signaling by endocannabinoid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00519">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000015">
        <property type="entry name" value="Sn1-specific diacylglycerol lipase alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052214">
        <property type="entry name" value="DAG_Lipase-Related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002921">
        <property type="entry name" value="Fungal_lipase-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45792">
        <property type="entry name" value="DIACYLGLYCEROL LIPASE HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45792:SF8">
        <property type="entry name" value="DIACYLGLYCEROL LIPASE-ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01764">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="19" id="KW-0966">Cell projection</keyword>
    <keyword evidence="9" id="KW-0967">Endosome</keyword>
    <keyword evidence="17" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="15" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="16 34" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-0628">Postsynaptic cell membrane</keyword>
    <keyword evidence="37" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0770">Synapse</keyword>
    <keyword evidence="7 34" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 34" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="34">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="34">
        <location>
            <begin position="42"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="34">
        <location>
            <begin position="84"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="34">
        <location>
            <begin position="119"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="34">
        <location>
            <begin position="449"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="domain" description="Fungal lipase-type" evidence="35">
        <location>
            <begin position="379"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="33">
        <location>
            <begin position="715"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="33">
        <location>
            <begin position="839"/>
            <end position="868"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="33">
        <location>
            <begin position="901"/>
            <end position="930"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="33">
        <location>
            <begin position="841"/>
            <end position="850"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00024531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00026104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00037872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00048382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00050486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00050709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00050861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="ARBA" id="ARBA00052106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="ARBA" id="ARBA00052463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="29">
        <source>
            <dbReference type="ARBA" id="ARBA00063298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="30">
        <source>
            <dbReference type="ARBA" id="ARBA00071957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="31">
        <source>
            <dbReference type="ARBA" id="ARBA00081678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="32">
        <source>
            <dbReference type="ARBA" id="ARBA00082132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="33">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="34">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="35">
        <source>
            <dbReference type="Pfam" id="PF01764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="36">
        <source>
            <dbReference type="EMBL" id="CAG5103093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="37">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="1082" mass="121519" checksum="B81A8615FC351396" modified="2022-05-25" version="1">MPGIVVFRRRWSVGSDDLVVPVLGVLLGIIPWDRSITCTLLLWNYILGYLIIFIISLGVELAICILSSRGSILDTAVRAPIKHFIYSLLLIETGWLCAGSTWLVYYYKNCSAVSEAKDVTLALVTITVWCTYDTAGRSWVKMKKYQRSMREAESRTGRMHYKRSGSRNRNWRQRKVIRAYQNSWDNRCRLLFCCMRNSDRNQNSFTDIARLLSDFFRDLDVVPSDVVAGLVLLRKFQKVERELIIKQRKNDTYEFLSGVPITPRTKFLSLTEDGDMLHFQDTIHYMHFALAAYGWPLFLINHTTGLCQLCTRIRCECFPCVKNDDDAIVIDDNCCQCNYAALQRMVDVGEVDVIYATFHVDIGETPFFVALDYTQRKLVISIRGTLSMKDVLTDLNAEAEVLPLTPPREDWLGHKGMVQAAEYIRRKITEEDIITKALNKNPERGTDQFGLTLVGHSLGAGTAAILAILLRQEYPDLICFSYAPPGGLLSMPAQQYTQEFITSVVVGKDVVPRIGLRQMESLRADLINAIKRSVDPKWKTIACSVMCCGCGSVPTSAANLEAGGSIAEYQRDKDQARAQTIVPSDSSIALTLHTPLYPPGKIIHVVRHHPNKGEEKYDSRWRQLLRKGEPVYQALWAEPGDFDEVLISPVMIQDHMPDNMLKALNKVSACRPKSAVITTSVQILGVGTSDNQHSMTLQHQSSTLYDVVTTLGPAKPQRLTSGHTSLAEASENRNPNKIEEREIEQEMRALLPKSPCKSRSLTIGTPPHRLCLETSFTSLQSPMELPHTERELSVDSRGVPWEYVSLASELITTPRHDDHKFFNHPLNWEYTQRIAPLATPETMSEASNSPSPLPSTRPIRRTPKIPRNLSTAADDLKSNLHYAMLASKNYGLCDEIAGSNSSSGNSEASYETTKSQRQGVQPPPVPQRRDSIILKREQTVCTAACCRDDLSDNSTPSSIHSTCIIRNTNQEEIDTNESNLDLYETKGFLTRRDSINIKSSPECRRLMTPVININAEWKKPFDTIGGTSVDTSLPLLRGLSPTPSQHTSPFSNAKRKKYVYPITLVGRGESSIKITKTFIICK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HQP8</accession>
    <name>A0A8J2HQP8_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Similar to sp9: Transcription factor Sp9 (Xenopus tropicalis)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">HICCMSTLAB_LOCUS13440</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Transcription factor which plays a key role in limb development. Positively regulates FGF8 expression in the apical ectodermal ridge (AER) and contributes to limb outgrowth in embryos.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the Sp1 C2H2-type zinc-finger protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5108804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HQP8"/>
    <dbReference type="OrthoDB" id="6365676at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd22547">
        <property type="entry name" value="SP6-9-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000077">
        <property type="entry name" value="Sp8 transcription factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000014">
        <property type="entry name" value="Transcription factor Sp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000026">
        <property type="entry name" value="Transcription factor Sp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235">
        <property type="entry name" value="KRUEPPEL-LIKE TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235:SF15">
        <property type="entry name" value="SP1, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="373"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="403"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="433"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="93"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="306"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="449"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="14"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="114"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="132"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="13">
        <location>
            <begin position="147"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="486"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="547"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="572"/>
            <end position="590"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00037677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00038409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CAG5108804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="608" mass="63821" checksum="1501B8AFF282A6F5" modified="2022-05-25" version="1">MFPLDQTSKQLVQKPERIREQNHQSNDLHETGLDETARFASGLITSKLSTEAKTYLKIDNLDDVITDNGSMEHPGLRGTPLAMLAAQCNKLSNKSPPPLADAAVGKGFHPWKKSPQSSGSSPQHTGGGGCTTTGVTQRPTATSSAGSTGGGGGGGGYARAPVTSCASTAPQYGSDMYFPGTASVQPASDPHHHQSSLLGKVEGATLSSVYGRHPYESWPFNTMTGATHGGIKASDGWWDVHGAATGGWLDVSGTVGVHAQMANYSADYSTSLALAGNHLLSSATTASHNLLQDTYKSMLPGGPPGFGLHAHHAASSGAGGAGSPQGATGVVTQAPSPRSQRRYTGRATCDCPNCQEAERLGPAGVHLRKKNIHSCHIPGCGKVYGKTSHLKAHLRWHTGERPFVCNWLFCGKRFTRSDELQRHLRTHTGEKRFACPVCNKRFMRSDHLAKHVKTHSSSSSSSGSKGKGGAGSSSAESCSDSEDNGSQQSPTSNSSSSTSVVAQGVPGQVVQGQQQGQHQAPQQPQQQQALAVVVGPQVGQDANGTSQTTTGLQQPTTPMTPMQMTPPPLTPHHPHHPHLPPLMHHPHHHATSVTAAAHHHPHAGMSMH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HQX5</accession>
    <name>A0A8J2HQX5_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS13215</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5108394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HQX5"/>
    <dbReference type="OrthoDB" id="7672712at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="431"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="471"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="431"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="498"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="518"/>
            <end position="535"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5108394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="535" mass="60018" checksum="A5D147B8940CCA76" modified="2022-05-25" version="1">MDLLKKQFLLWQTQIEKKIPCHFCGAKLSEKIFSCEFGHDCCLSCKTQSCMACPNSNPFLRNHLSEFLISQFNNLKSCVEQLDISAINPKNDNKNSSKVNKATETNIERHNKMSMATEKDINIFSGNKASAGTKPTVKSPANGSIKVSDGKLIIQANSDSLSENSYSCWIGTCNFRGIYEDILKHMKANHSSVFTSHELKGWPHIMNLHLNYTGPDSRQDYAFELQGIGLFVLHISVSPKENMKAHVLMFDSAKIAAQYGFNVEIKCDDQKKSFSAVVDSSRMPRRNLQDVAKGLFINENSLLLNTIKLRMNFKCVLEINTFNKSIFNGILDSSLRNSDLQKKPSNDQKPRLFLNKPNFKPRRNFNYAKNQSSMPALLDLKVPNPPVTPVTQPQVQPTPQPAVDSQQLMMLFEQMMVNYTQKMTQSKIQTPQAQQSSVINSSSILQPSTVQTQDKSPQKIVEDQASAVKNPVTVPAQSSQLQDLLIFDESNKSEDSTLNKVQTPSPTAETTTVDESEETKQEESDSKPNNDCKIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HR90</accession>
    <name>A0A8J2HR90_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Obg-like ATPase 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HICCMSTLAB_LOCUS13442</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Hydrolyzes ATP, and can also hydrolyze GTP with lower efficiency. Has lower affinity for GTP.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="9">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. YchF/OLA1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5108806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HR90"/>
    <dbReference type="OrthoDB" id="424823at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043023">
        <property type="term" value="F:ribosomal large subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04867">
        <property type="entry name" value="TGS_YchF_OLA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01900">
        <property type="entry name" value="YchF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.300:FF:000003">
        <property type="entry name" value="Obg-like ATPase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.30:FF:000029">
        <property type="entry name" value="Obg-like ATPase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.300">
        <property type="entry name" value="TGS-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00944">
        <property type="entry name" value="YchF_OLA1_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004396">
        <property type="entry name" value="ATPase_YchF/OLA1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031167">
        <property type="entry name" value="G_OBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004095">
        <property type="entry name" value="TGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012676">
        <property type="entry name" value="TGS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023192">
        <property type="entry name" value="TGS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013029">
        <property type="entry name" value="YchF_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041706">
        <property type="entry name" value="YchF_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00092">
        <property type="entry name" value="redox-regulated ATPase YchF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23305">
        <property type="entry name" value="OBG GTPASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23305:SF11">
        <property type="entry name" value="OBG-LIKE ATPASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06071">
        <property type="entry name" value="YchF-GTPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006641">
        <property type="entry name" value="CHP00092"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81271">
        <property type="entry name" value="TGS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51710">
        <property type="entry name" value="G_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51880">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OBG-type G" evidence="10">
        <location>
            <begin position="22"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="domain" description="TGS" evidence="11">
        <location>
            <begin position="272"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="31"/>
            <end position="36"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="213"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAG5108806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="367" mass="41355" checksum="E1EDF9E0B3FF6467" modified="2022-05-25" version="1">MPPKKVEEPERKPLIGRVGTNLKIGIVGIPNVGKSTFFNVLTKTRRVPVPDARFDYLCEYYKPVSKVPAFLNVVDIAGLVKGAAEGQGLGNAFLSHINACDAIYHLCRAFEDDDVTHIEGEVNPVRDLEIICEELRLKDVEMLNGHLEKLEKLVVRGNDKKLKPEYDTLLKVKTILVEEKQQVRFADWSLNDIDVLNKYLFLTSKPVIYLVNLSEKDYIHKNDPGATLIPFSGVFENKVIDMDDAERAKYFEESKVTSALEKIIVQGYKALQLQYFFTAGHDEVKAWSIQKGTKAPQAAGRIHTDFEKGFIMAEVMKFEDFKNEGSEAAVKAAGKYRQQGRHYVVDDGDIILFKFNAGAGLKDPKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HRF8</accession>
    <name>A0A8J2HRF8_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Similar to e(Y)3: Supporter of activation of yellow protein (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">HICCMSTLAB_LOCUS11850</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5104134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10004495at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000987">
        <property type="term" value="F:cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042594">
        <property type="term" value="P:response to starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048589">
        <property type="entry name" value="SAMD1-like_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14596">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14596:SF72">
        <property type="entry name" value="ZINC FINGER PROTEIN MSN2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21524">
        <property type="entry name" value="SAMD1_WH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52014">
        <property type="entry name" value="SAMD1_WH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="3" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="8" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SAMD1-like winged helix (WH)" evidence="14">
        <location>
            <begin position="956"/>
            <end position="1032"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="13">
        <location>
            <begin position="1448"/>
            <end position="1499"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="13">
        <location>
            <begin position="1496"/>
            <end position="1545"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="225"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="368"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="407"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="502"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="594"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="738"/>
            <end position="871"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1129"/>
            <end position="1153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1341"/>
            <end position="1445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1562"/>
            <end position="1601"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="28"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="615"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="650"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="662"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="809"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="853"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="1129"/>
            <end position="1141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="1341"/>
            <end position="1365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="1430"/>
            <end position="1440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="1562"/>
            <end position="1582"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="1588"/>
            <end position="1597"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS52014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CAG5104134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="1675" mass="183910" checksum="DE68280ADF59A020" modified="2022-05-25" version="1">MSDLIDLTSPEEKKIKPPKLTSPLIPLPDDKGNPGESKHINNPIINLEACGNLDDNPFDSALRKTSEFVSKSQDPFEIVWEKSMNSTRKSCRSTGDKLNKTADGFVTPSVTSVPKNVTKSKNPVISVKPPTPEFHELSILDQSCLNDSFLLDSSVTGRPSTERYLKRLASDIESPNFELSQSILNQSTLNDSLSGTNSDDCPIKSIAAQRLASCVQQGLKQAEAARKNQGYHHQRSLSQGCHVSPHYSKSSRSYSATSVGLDKSLQELELASRDTLLNPLNNGFLNSSRDTISDISFIRKFSSASGGSSTDTYNKINRAFIASKSLIENDTVRKSINSRLSTSFAEISDLKAKLSLLKSKSLLGSLERNETASDSDELPSRIPSDSEVLTDNEVRVENLIELSSDTSNSTGFNSADKVQSSSQSHLKSNDNSSVDVVRELEKELIDAENKPAAASLLMDLKKLIKAENNSQAIELLKNLEKMLGVKCQSNADLLEIFMNSSTSSSLNKDKNSNNFEDTSIKSSDFTHDTIKENISKGDSINSSDSKDKSQNSSTLKLIAGIQESLEKLLSENVGQPKLLLKKLNSVFSSIVSSEKTPATSPVKTARVSPMKNPGLSRSVSSLARRSVDSPTKKSFGLKRRTSMTQIPYTGSSRRSSSVGRSVRADSPKKEIKSRLSSSAYQVTKSQVQQEVAVKIKPVPVIGKSKLRKKPEQALEVTKKGPLKAVIPLGNMHRRASLGKRVAPTTPPKSARASIGKTSTPNTGEEVLDCLKKPPKTKPLAASTPEGGYKNTRSSLPVPKSPRPSCSISPVTPKTPMVTPKTPRGSSPRVTPGVKVSHRLSLSSQPINKPGHSRRSEPVKQDLSKSESSKKIPGVLTEQNTPVAKVNPINLTSKFVLHASSVYARAQYTIMRSAIYTRLRRRISNSASLFSFINPTRQFSELPSFAIAKKKSNMQQHRVEAQILYEEQILEAIDQLRRRKARPDADRICNYLLRKFCVDARDTIADLHRLIEAEKVIQVDYKGNTSYRNASKWSRLQLYKNRPEGFVKDKLSSASVAGAVAELVIEEPDYLDQGVPPFRLIEHLLDGISNPTSRKMVEDFLNKEVASGNIIRSANGNYSLVATSDTSNTTLNSTISSSSSSSSPPPRANLITNNHMDNEVIAGSKKFSRDDININIINCNNSGNINNDNPNSGLNCNYDNNLLMTDSRSSTPKITSSRLVVGSNNNNNNNNNNNGSIGTVASKREQCFEVAVAVKEPNSPEESGTKDDLVLCTEDNIPMATAMAMSNDTAEKKEPKTEVVITSNLKRSAKSERKQRLMVRADDSMDIEIKFDEIKYESKFNDTKEKAKEKEKEKEKEKEDSENLSEKEDEEAEAERSSANPSPTLSNPVGGFRSARRKRAKKVFDPSDNNVVKRKRGRYATAATKASLQVTTQDSQDSTSSKPSVKETGRKCSLCYKDKAESLIPCRDCTVRAHPSCIYSPDDLLLKTGSSWQCERCKSCTVCCETSDIGPLLTCYTCDDAYHYSCHTPRVIRSGSKWQCCECKPQPSKTVTTVVPTASTALTTNSTASTTPTASITTPAAAPRSETPPQTPTLPPVLSPQVSPSRESLEAIEDETIPRDSVIDPNIPDASDWTSEQVYQSDVLIGLDLLLGPALKIYRHVLKLQMRRDETRFYWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HSK7</accession>
    <name>A0A8J2HSK7_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Similar to WDR20: WD repeat-containing protein 20 (Homo sapiens)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HICCMSTLAB_LOCUS12815</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5107581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HSK7"/>
    <dbReference type="OrthoDB" id="3367at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051362">
        <property type="entry name" value="WD_repeat_creC_regulators"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14107:SF16">
        <property type="entry name" value="AT02583P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14107">
        <property type="entry name" value="WD REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="267"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="338"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="419"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="495"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="361"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="420"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="516"/>
            <end position="552"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAG5107581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="654" mass="71884" checksum="A31FCE3C87D8676D" modified="2022-05-25" version="1">MAVQLDGGGKEDLKTQFVTREGTYKLMTLSEYSRPNRVGNTDTRGSASVRVSFVTLPDPADPTGTQGLGDRMCFNFGKELFVYVYRGVKKAVDLNKPVDKKLYKGTNPTCHNFNQTTATADTAPLLVGFSTGQIQLIDPIKKELNKLYNEERLIDKTKVTCIKWVPGSSNLFLVSHSSGQLYLYNWELPCGTTSPHYQPFKSGDGYAIHTCKTKSTRNPLYRWVIGAEGCCINEFAFSPCGTNLAVVSQDGFLRVFHYDTMELVGSARSYFGGFLCVCWSPDGRYVVVGGEDDLVTIWSFHEKRVVARGQGHHSWVSVVAFDPFTTCYGEADGDFSGSDDEAMQQQHQHNNHNHFNDKSNRLSTTSQGVHSNRNSCSSELRVPGGTCYRLGSVSEDTQLCLWDITEDVLRQPVCAKQRVSAAGSGTLSSSGTLSSGNGATSNHVTNNTKFNNINNVSFNKDSTGSHNNSDSSTNNSSTNTAVSTVNSLTQRFAGLGFGERNKGDNHKRNFSLTMRSSSTSNNSNTVVNSGDNNKASSNNTNTSNLNSVGGNSIGGSNKKASFVMDDPMRLIGTAWCPRFDECPVLEPLVCKKLAHERLTELVFREDCFVTACQDGYVYTWARPGQQHMVSSTLHRPHHHSNLLTNINSMRLNDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HTQ0</accession>
    <name>A0A8J2HTQ0_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9 10">U6 snRNA-associated Sm-like protein LSm4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LSM4</name>
        <name evidence="13" type="ORF">HICCMSTLAB_LOCUS13315</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Binds specifically to the 3'-terminal U-tract of U6 snRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">LSm subunits form a heteromer with a doughnut shape.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the snRNP Sm proteins family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5108594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HTQ0"/>
    <dbReference type="OrthoDB" id="747253at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120115">
        <property type="term" value="C:Lsm2-8 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000956">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01723">
        <property type="entry name" value="LSm4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000005">
        <property type="entry name" value="U6 snRNA-associated Sm-like protein LSm4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034101">
        <property type="entry name" value="Lsm4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027141">
        <property type="entry name" value="LSm4/Sm_D1/D3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23338">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6 10" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 10" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Sm" evidence="12">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="68"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="68"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="82"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00067757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAG5108594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="131" mass="14374" checksum="4BEA731EE92F2C30" modified="2022-05-25" version="1">MLVELKNGETYNGHLVSCDNWMNINLREVICTSRDGDKFWKMPECYIRGSTIKYLRIPDEVIDMVKEDVQMKSRGRGEMKGRGGQSQRGGRGGGRGGGTFGNRGSRGPAPLGRGSGGNQGGNKLLNKNRNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HTY3</accession>
    <name>A0A8J2HTY3_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS13499</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5108863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HTY3"/>
    <dbReference type="OrthoDB" id="10519844at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035250529" evidence="1">
        <location>
            <begin position="18"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5108863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="203" mass="21680" checksum="6D29837A6B2C7940" modified="2022-05-25" version="1">MKLLFVITISVWSLVNSDIISTNSNDGSGNSKSVAINNNQEILNVGNQANANQANVNGLVAINGQFQQQQQQQQQVVGLGGLLDQIGTLLNSILNQLLQINVISNALNQNQLLLPLLTEVRAILQNLLNSLLNSNQNPLILQVNNLIAQVGNLLNLINQKSLFGGLLGQLLSPVGNIFVGGALQIGLVPSLLLQVMNILSNLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HU51</accession>
    <name>A0A8J2HU51_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Acetyltransferase component of pyruvate dehydrogenase complex</fullName>
            <ecNumber evidence="5">2.3.1.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HICCMSTLAB_LOCUS13651</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="5">The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>N(6)-[(R)-dihydrolipoyl]-L-lysyl-[protein] + acetyl-CoA = N(6)-[(R)-S(8)-acetyldihydrolipoyl]-L-lysyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:17017"/>
            <dbReference type="Rhea" id="RHEA-COMP:10475"/>
            <dbReference type="Rhea" id="RHEA-COMP:10478"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:83100"/>
            <dbReference type="ChEBI" id="CHEBI:83111"/>
            <dbReference type="EC" id="2.3.1.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>(R)-lipoate</name>
            <dbReference type="ChEBI" id="CHEBI:83088"/>
        </cofactor>
        <text evidence="5">Binds 1 lipoyl cofactor covalently.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the 2-oxoacid dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.12" evidence="5"/>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5109015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HU51"/>
    <dbReference type="OrthoDB" id="537444at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045254">
        <property type="term" value="C:pyruvate dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004742">
        <property type="term" value="F:dihydrolipoyllysine-residue acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006086">
        <property type="term" value="P:pyruvate decarboxylation to acetyl-CoA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06849">
        <property type="entry name" value="lipoyl_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.100:FF:000010">
        <property type="entry name" value="Acetyltransferase component of pyruvate dehydrogenase complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.559.10:FF:000003">
        <property type="entry name" value="Acetyltransferase component of pyruvate dehydrogenase complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.320.10">
        <property type="entry name" value="E3-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001078">
        <property type="entry name" value="2-oxoacid_DH_actylTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045257">
        <property type="entry name" value="E2/Pdx1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036625">
        <property type="entry name" value="E3-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006257">
        <property type="entry name" value="LAT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004167">
        <property type="entry name" value="PSBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01349">
        <property type="entry name" value="PDHac_trf_mito"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23151">
        <property type="entry name" value="DIHYDROLIPOAMIDE ACETYL/SUCCINYL-TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23151:SF90">
        <property type="entry name" value="DIHYDROLIPOYLLYSINE-RESIDUE ACETYLTRANSFERASE COMPONENT OF PYRUVATE DEHYDROGENASE COMPLEX, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00198">
        <property type="entry name" value="2-oxoacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02817">
        <property type="entry name" value="E3_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47005">
        <property type="entry name" value="Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="Single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51826">
        <property type="entry name" value="PSBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3 5" id="KW-0450">Lipoyl</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Lipoyl-binding" evidence="7">
        <location>
            <begin position="68"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="Peripheral subunit-binding (PSBD)" evidence="8">
        <location>
            <begin position="205"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="165"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="174"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAG5109015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="482" mass="51649" checksum="945B2456815FBF2A" modified="2022-05-25" version="1">MLLRTTAQLRNDLARVTLRNSIRTNVVRCLTTRCLHRRSLQRYQGSGGKFSVEPWRQQFRYYADYPDHIKVALPALSPTMETGTIISWQKKEGSDKLNEGDLLAEIETDKATMGFETPEEGYLAKIIQPAGAKNIGIGSLVCIIVSDEGSVAAFKDFKDDGSAASAPKAAPAAAAPPPPPPPKAAPKAAAPPPPSMPTTAGDRVFASPLAKRLAAEQGLSLQGLRGTGLFGSITAKDLGGAGPAMSAGTAHAGGMDIPVSNVRGVIAKRLLESKQTIPHYYLTIDVKMDAALKMREQFNRMMEKENVRVSVNDIIIKAMAMACKKVPEGNSAWLGNVIRQYDNVDVSVAVSTESGLITPIVFGADWKGIAQISKDVKALAAKAREGKLQPQEFQGGTITVSNLGMFGIKQFSAIVNPPQSIILAIGTTENRLIPADNERGYNSAQFMSVTASCDHRTVDGAVGAQWLSAFRSLMENPMTMLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HU54</accession>
    <name>A0A8J2HU54_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Similar to Acyl-CoA-binding protein (Gossypium hirsutum)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HICCMSTLAB_LOCUS13633</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ACBP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5108997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HU54"/>
    <dbReference type="OrthoDB" id="346910at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000062">
        <property type="term" value="F:fatty-acyl-CoA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019915">
        <property type="term" value="P:lipid storage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.80.10:FF:000010">
        <property type="entry name" value="Acyl-CoA-binding domain-containing protein 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022408">
        <property type="entry name" value="Acyl-CoA-binding_prot_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000582">
        <property type="entry name" value="Acyl-CoA-binding_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035984">
        <property type="entry name" value="Acyl-CoA-binding_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014352">
        <property type="entry name" value="FERM/acyl-CoA-bd_prot_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23310:SF62">
        <property type="entry name" value="ACYL-COA BINDING PROTEIN 1, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23310">
        <property type="entry name" value="ACYL-COA-BINDING PROTEIN, ACBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00887">
        <property type="entry name" value="ACBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00689">
        <property type="entry name" value="ACOABINDINGP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47027">
        <property type="entry name" value="Acyl-CoA binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00880">
        <property type="entry name" value="ACB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51228">
        <property type="entry name" value="ACB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ACB" evidence="3">
        <location>
            <begin position="3"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG5108997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="89" mass="10082" checksum="31C6211A4A5D2913" modified="2022-05-25" version="1">MSVQEEFEKAAQEVKELASEPSNEDKLILYGLFKQATIGNCNIDKPGYFNLKDKAKWDAWNAKKGTSKEDAQKDYIKKVAQLIESIGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MAG8</accession>
    <name>A0A8J2MAG8_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS2802</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001117">
        <property type="protein sequence ID" value="CAG5078657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MAG8"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5078657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="69" mass="8059" checksum="A371E1A2AA84CC7E" modified="2022-05-25" version="1">MVMKCREECVCRCGWVSLTGLLLDNSKICSTEIPINDIFHWPDHEEREYPSKVLCKEDKVPRLESFLST</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MBS2</accession>
    <name>A0A8J2MBS2_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">uridine/cytidine kinase</fullName>
            <ecNumber evidence="3">2.7.1.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HICCMSTLAB_LOCUS2834</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>cytidine + ATP = CMP + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24674"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17562"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.48"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>uridine + ATP = UMP + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16825"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16704"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.48"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Pyrimidine metabolism; UMP biosynthesis via salvage pathway; UMP from uridine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the uridine kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.48" evidence="3"/>
    <dbReference type="EMBL" id="CAJNRD030001117">
        <property type="protein sequence ID" value="CAG5078773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MBS2"/>
    <dbReference type="OrthoDB" id="10257085at2759"/>
    <dbReference type="UniPathway" id="UPA00574">
        <property type="reaction ID" value="UER00637"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00579">
        <property type="reaction ID" value="UER00640"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004849">
        <property type="term" value="F:uridine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044211">
        <property type="term" value="P:CTP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044206">
        <property type="term" value="P:UMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd02023">
        <property type="entry name" value="UMPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006083">
        <property type="entry name" value="PRK/URK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000764">
        <property type="entry name" value="Uridine_kinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10285">
        <property type="entry name" value="URIDINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00485">
        <property type="entry name" value="PRK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00988">
        <property type="entry name" value="URIDINKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phosphoribulokinase/uridine kinase" evidence="9">
        <location>
            <begin position="45"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAG5078773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="292" mass="32798" checksum="C509529FFA57FED8" modified="2022-05-25" version="1">MQVSKNTDLKAMADVPIIDLGGMSRKMSYGFNNPFNGVEGKTPFLIGVSGGTASGKSTVCKRIMEKLGQVDMDHTERQVVCISQDCFYRDLTPAEKLRAEKGQFNFDHPDAFDNDLILSTLQDILAGVKCEVATYDYRTNSLLRDQTTTIYPADVVLFEGILVFYFHKIRDLFHMKLFVDTDSDTRLARRAFEEFCLPTKKFADVIIPRGADNTVAIDLIVHHIWDILHSKKMNGAEMPPVPGQHPYLHLAIDLIVQHIRDLLVERASSGRVVVEPESPVASHSEGLLKRPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2ME43</accession>
    <name>A0A8J2ME43_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Small ribosomal subunit protein uS17</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">40S ribosomal protein S11</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">HICCMSTLAB_LOCUS4340</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the universal ribosomal protein uS17 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5085313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2ME43"/>
    <dbReference type="OrthoDB" id="10254436at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00364">
        <property type="entry name" value="Ribosomal_uS17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.1000:FF:000008">
        <property type="entry name" value="40S ribosomal protein S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000266">
        <property type="entry name" value="Ribosomal_uS17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028333">
        <property type="entry name" value="Ribosomal_uS17_arc/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019979">
        <property type="entry name" value="Ribosomal_uS17_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032440">
        <property type="entry name" value="Ribosomal_uS17_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006345">
        <property type="entry name" value="PRK08572.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03630">
        <property type="entry name" value="uS17_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10744">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S11 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10744:SF9">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00366">
        <property type="entry name" value="Ribosomal_S17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16205">
        <property type="entry name" value="Ribosomal_S17_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00973">
        <property type="entry name" value="RIBOSOMALS17"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00056">
        <property type="entry name" value="RIBOSOMAL_S17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0007">Acetylation</keyword>
    <keyword evidence="7" id="KW-0164">Citrullination</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-0488">Methylation</keyword>
    <keyword evidence="10" id="KW-0564">Palmitate</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 15" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="8 15 17" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Small ribosomal subunit protein uS17 N-terminal" evidence="16">
        <location>
            <begin position="4"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00035164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00035471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU003872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF16205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CAG5085313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="155" mass="18035" checksum="C8ABE9FDC0561B92" modified="2022-05-25" version="1">MADQVERAFLRQPAIPLFRKSLTKQKTKAVERYTRDVGLGFKTPREASEGTYIDKKCPFTGNVSIRGRILTGVVQKMKMQRTIVVRRDYLHYVRKYSRFEKRHRNMSVHLSPCFRDVEIGDTVTIGECRPLSKTVRFVVLKVSKSTSSKKSFKKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MG86</accession>
    <name>A0A8J2MG86_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Similar to Scoloptoxin SSD14 (Scolopendra dehaani)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HICCMSTLAB_LOCUS5018</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5088894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MG86"/>
    <dbReference type="OrthoDB" id="1081007at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036374">
        <property type="term" value="F:glutathione hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006751">
        <property type="term" value="P:glutathione catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.246.130:FF:000001">
        <property type="entry name" value="Gamma-glutamyltransferase 5 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.40:FF:000001">
        <property type="entry name" value="Gamma-glutamyltranspeptidase 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043138">
        <property type="entry name" value="GGT_lsub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000101">
        <property type="entry name" value="GGT_peptidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043137">
        <property type="entry name" value="GGT_ssub_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00066">
        <property type="entry name" value="g_glut_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11686">
        <property type="entry name" value="GAMMA GLUTAMYL TRANSPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11686:SF9">
        <property type="entry name" value="RE13973P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01019">
        <property type="entry name" value="G_glu_transpept"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01210">
        <property type="entry name" value="GGTRANSPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1199">Hemostasis impairing toxin</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-1202">Platelet aggregation activating toxin</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0800">Toxin</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="2">
        <location>
            <position position="425"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="146"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="443"/>
            <end position="445"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="467"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="496"/>
            <end position="497"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="519"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00084097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR600101-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR600101-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAG5088894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="1005" mass="110205" checksum="A125240502C64FF4" modified="2022-05-25" version="1" fragment="single">MKHQIESITIETKNSKWRSKRWKIIAGVAVLAVIAIVIVAVLLSKGSKKIDENDDDVEKIPDVEKYQPPSSSKLSKFKRGAVCVDDAYCAEVGSKILERNGSAIDAAIAAALCNGMANMQNMGLGGAFVMTVYDKASKKAYYLNARDRAPMAAFGDMYRNKSKGASFTGPLAVAVPGEIAGYWAAHQKFGRLKWAELFTDAIAMCENGWKLSNAQWSDLFQNKASIENDPTLRSLFVNETTKEFKKPGSIIKADKLCKTYKVLAEKGAGEFYNGTLGQTLIEDLRKHGGILTMDDLITYSAKWQEPLETELSDGLKLFASNFPTSGALLIFIMNIFDEFKFNPNSLNGDENTIKTYHRMIETFKYAFAVRSKLGDPEFHNMTELANNLTSRDYARAIKARINDSRTWNDTAHYEGGSRLLEDHGTAQISVVSPDGDAVSITSTLNTFFGSGLVSENTGILLNSGMDDFSIPYITNYFDLPGNAKENLIEPGKRPFSSMVPSVLVDPNGDLRMVIGSCGGTKITTSAAFVMARTLWMNNTIKEAIDAPRIHHQLYPMKVGYQYGVLKSVIEGLQKLGHETARYRGRGSVVCAIEKLNGLLYGNADYRRNGGVSVAGDDAVCAEIGKSILKKNGSAVDSVIAASLCTSLGFMQSMGIGGGLVMTIYDKATKKVYYLNARDRAPLGVHKDIYKDKSEASLEGALAVAVPGEIAGYWAAHQRFGKLPWADLFTDTIALCEKGWKLSQIQLNDLLRKEECINKDPTLRSLFVNETTKEFKKPGNYARAIKARIDDSRTWNDAAHYEGSTWLHEDHGTSHLVVLSSTGDAVSLTSTINTPFGSCLVGEKTGILFNNNMDDFSIPTVVNYFGLPGNSKQNSIQPGKRPLSSMAPSILVDSDGNVKMIIAASGGTRIISSLACALARVLWMNNTIKEAIDTPRLHHQLLPMMINYEFGTSNSVIQGLKNLGHQVSQDNYQAYSFVAAIFKSTDFIYANSDFRRNGDACVTYPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MG89</accession>
    <name>A0A8J2MG89_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HAT C-terminal dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS3001</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001117">
        <property type="protein sequence ID" value="CAG5079399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MG89"/>
    <dbReference type="OrthoDB" id="8046116at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5079399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="118" mass="13090" checksum="1377206104F18FC0" modified="2022-05-25" version="1">MWIEICNFTRSDGTLQFPNLRLLLSIIRALAHSNTAAERAFSLIPNFKTKKRNNLSHITLNSLCVIKSVSNSGNLRVSEISIDKSYIGLMSSCNLYSKAKKAAPKSLTLYSCESSDDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MGK7</accession>
    <name>A0A8J2MGK7_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">MADF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS5578</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5090307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MGK7"/>
    <dbReference type="OrthoDB" id="7697930at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5090307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="304" mass="35109" checksum="8395247BA01965C4" modified="2022-05-25" version="1">MDLNLRKPMFLLDNLTNDISGNKLPTNKQVLRLLFHCTKNMKTTVYEGCKITIEKVKKFWVFAGIFILDDKRCIKKLESLHEEYRMVHKNAGIPSNHQKEQEFFLKLEQLFDIAHSRIFEMVSNEIKNFLIDQRSDRNLHLNFSANQQSRPNELSENLLVNVDHFNEPSTSKIPLSENDDSFIKLSPCQEIKTISQSIEHESDNVELTRKISNNYLPSSSISSEGIMSSGEMISSSSPPSQRSEFEVGGRYYNRKNERGVINIMTENVVATLDNCKVSYRNSVRIISAISEALQFDKYLNRMMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2023-09-13" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MGV2</accession>
    <name>A0A8J2MGV2_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS5760</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5090825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5090825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="15" mass="1804" checksum="8FF41D753060F17C" modified="2022-05-25" version="1">MAAKTRRSYSLFLFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MGV4</accession>
    <name>A0A8J2MGV4_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Similar to Pxn: Peroxidasin (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HICCMSTLAB_LOCUS2927</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001117">
        <property type="protein sequence ID" value="CAG5079115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MGV4"/>
    <dbReference type="OrthoDB" id="5954366at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000082">
        <property type="entry name" value="Leucine-rich repeat-containing 24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000483">
        <property type="entry name" value="Cys-rich_flank_reg_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050467">
        <property type="entry name" value="LRFN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45842:SF12">
        <property type="entry name" value="KEKKON 5, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45842">
        <property type="entry name" value="SYNAPTIC ADHESION-LIKE MOLECULE SALM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00082">
        <property type="entry name" value="LRRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 8" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035161966" evidence="8">
        <location>
            <begin position="19"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="373"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="9">
        <location>
            <begin position="261"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="512"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="599"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="635"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="520"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="534"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="655"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="673"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="708"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="738"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="755"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="798"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="808"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAG5079115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="808" mass="88903" checksum="E3CF60C41DD3D70F" modified="2022-05-25" version="1" fragment="single">MRLSSLLFISLLLRLSNSQEPWDCGPPCKCKWVSGKKTADCTQQNFTHIPSYLLPDTQNLDLTQNHISHVQEGAFTRVGLVNLHKLVMRHCGIHTIHSGAFNGLKIVIEVDLSGNHITNLMPGTFLETQKLRVLLLNHNSLKSLDDGLFHDLEHLQRVEISQNRLERIAENTFKNLPGLLTLALNDNNITSVKLATFENLPKLGSLELRNNPWHCNCHLKKFRNWTLERKLYTKGTTCFLPEALAGKGWDEVDSDEFACRPKILSIGAYPQIGVGDTVTMWCHALGIPRPQLSWVHRSRVLNNSTKRQTSDRGYYLLEGHDWLNLTITDVIPYDKGEYICIAKSPGGSVERNLTLAIAGDVDSGKTSLISLPLALGLGVTLLIFLLFFLTVCTWYWRRKKRHEGEKSADVTSLEHHGLGEQEKSLITAINPVVKPPRRYEAPSVTSHGTEMTELNRTLLDNDSVFADGVGSIIGVMGGMLDDRSRATPEPHIDSSTLLRGASYRHYPPDLLAFSGGRGASPTSQSSTLPDTRSSTHYQHQSHPQQSPSQQQSPRGFSPSSGQYPAAFKTLPHNLNRQMGVYSPVHPVMPRHGYVTIPRRPRAPSWSSGPPSSPVDHLEPVYDNLGARTTADGSSVLSLNKINKSPEPVSSMRMRPLPSTPTSSSAKPQASTPTPAPALSPLSPPRSTPTPPGSTPTSLPQTSARFHSIQRSTPNIFNSSGHPLDRSAPEGAPEWFAKLPDEMEKRGRRESSSPLTISPGQTPTTPSSSSPNTSSTLGRKIPPRPPPKPKKKSNNGPLYEDEGEDGTEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MIU0</accession>
    <name>A0A8J2MIU0_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Trypsin-2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HICCMSTLAB_LOCUS4823</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5088392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MIU0"/>
    <dbReference type="OrthoDB" id="10059102at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000034">
        <property type="entry name" value="Eupolytin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033116">
        <property type="entry name" value="TRYPSIN_SER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24252">
        <property type="entry name" value="ACROSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24252:SF7">
        <property type="entry name" value="HYALIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00135">
        <property type="entry name" value="TRYPSIN_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="1 5" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0720">Serine protease</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035272287" evidence="7">
        <location>
            <begin position="23"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="291"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="8">
        <location>
            <begin position="38"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAG5088392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="319" mass="35075" checksum="DF2B1837D3936B8E" modified="2022-05-25" version="1">MYLSTWCLLIILFSGLSHVTGAQKIAVLNRNARWTGRIVNGEKATYAQFPFIASLQKRWTIVQHFCGASIITDRWVLTAAHCVVRDKSLVPQWGLVVVAGETNIYTYHSFHRQIRNADQLVVNPRFDMRSLANDIALISLQSPFVFSTSLQPIPLSKSTPSAGTNCTVAGWGHLAENNRSSVDELMYVHLPIISYDYCGKLLWGIVNMHPSIICAGYIEGGKDACQGDSGGPLVCGDLLVGIVSGGRGCARPKLPGFYTNVAYYKRWIDQVLRSNGKNHSYNGFNRHPASALAASISAGLVYILSCPLVIVYLQDIIKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MMZ9</accession>
    <name>A0A8J2MMZ9_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Similar to ADAMTS1: A disintegrin and metalloproteinase with thrombospondin motifs 1 (Homo sapiens)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HICCMSTLAB_LOCUS9209</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5099737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MMZ9"/>
    <dbReference type="OrthoDB" id="7695528at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006509">
        <property type="term" value="P:membrane protein ectodomain proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1620.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041645">
        <property type="entry name" value="ADAMTS_CR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001590">
        <property type="entry name" value="Peptidase_M12B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11905">
        <property type="entry name" value="ADAM A DISINTEGRIN AND METALLOPROTEASE DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11905:SF249">
        <property type="entry name" value="SOL NARAE, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17771">
        <property type="entry name" value="ADAMTS_CR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01421">
        <property type="entry name" value="Reprolysin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50215">
        <property type="entry name" value="ADAM_MEPRO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="4 8" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035311684" evidence="9">
        <location>
            <begin position="21"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M12B" evidence="10">
        <location>
            <begin position="245"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="321"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="320"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="324"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="330"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAG5099737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="478" mass="54006" checksum="F96507DBCD4A1BA1" modified="2022-05-25" version="1">MKSLAILLVLVLQSFKSGYSAQLHELMTDEEIQSVFQSNRDSVPKYEVVPILHSMNKKNVKYPEVYFHAFGNDISLYLWPAEGLLFGKHTPVYTVQSDKLSSTGLRYTEYDEYGIYYAFRDDNNNAAIIVRDGMYNKYKFDGTFNKNYVIRSLSPRVIENVILKNISFFKANLFPTPNSRSSYFLANHHVIYRMNDTNIKLKNPRNLIFPDNPVDQDATPYLNGYRVNDNAIDVEAMKPMGKFLYNETKFGKNSYDIAVLLTKLQVCEWTSPRNDRSQCIPLRGISNFGSACAWSKSNKAVEAIAFVHDEGFNGIATAAHELAHVLGVPHDGSASARYVGGPGATRCKWEDGYLMSSNRFDKKAFTWSKCTKECFKHFLQLPIAKCLFNKPTMNRELPKILPGTLLSLDEQCAEAGALDACHHDERACTLLFCSRKNNSDDCFSTGPAAEGSTCGNEKICIQGQCVNKRQWRTPGIKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MNV3</accession>
    <name>A0A8J2MNV3_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Solute carrier organic anion transporter family member</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HICCMSTLAB_LOCUS8804</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Cell membrane</location>
            <topology evidence="1 8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the organo anion transporter (TC 2.A.60) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5097641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MNV3"/>
    <dbReference type="OrthoDB" id="5062115at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016323">
        <property type="term" value="C:basolateral plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015347">
        <property type="term" value="F:sodium-independent organic anion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006811">
        <property type="term" value="P:monoatomic ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043252">
        <property type="term" value="P:sodium-independent organic anion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002350">
        <property type="entry name" value="Kazal_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036058">
        <property type="entry name" value="Kazal_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004156">
        <property type="entry name" value="OATP"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00805">
        <property type="entry name" value="oat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11388">
        <property type="entry name" value="ORGANIC ANION TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11388:SF142">
        <property type="entry name" value="SOLUTE CARRIER ORGANIC ANION TRANSPORTER FAMILY MEMBER 5A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07648">
        <property type="entry name" value="Kazal_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03137">
        <property type="entry name" value="OATP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100895">
        <property type="entry name" value="Kazal-type serine protease inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51465">
        <property type="entry name" value="KAZAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035312882" description="Solute carrier organic anion transporter family member" evidence="11">
        <location>
            <begin position="19"/>
            <end position="988"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="192"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="233"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="352"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="392"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="419"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="557"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="594"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="629"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="757"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="795"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="848"/>
            <end position="870"/>
        </location>
    </feature>
    <feature type="domain" description="Kazal-like" evidence="12">
        <location>
            <begin position="675"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="53"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="914"/>
            <end position="954"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="259"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAG5097641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="988" mass="108788" checksum="F2F918BF00C4047F" modified="2022-05-25" version="1">MITEALIVFFFLFQDVEEYKNNAEPELVIPLVWTSKRSLEVEELTSERELLSPGAAAAMASTSGHKRNGSSSSMFAHRRTESGSGFIGHKRPETGHKRAESISTAFGHKRNDSYGGFGHKRSFITSESGSNYHAGHRRNESMYAMTGLYAESAGNIIDDPLDLPQLSDGRLTHDTVIRCHSRNPSSGLVDHSMAAFGPVLGFLLGAYLLSFHMDSFSANIISIDPGDHRWVGMWWGGFLLCGLLLILVAIPFFSFPKTLQHEKEKIKIIEKNKSAIAKEKEANKDLKKEVKNDDSGYGKDVKVDNFHQCNFKLNRLTEKERPQTPPINPDSKDCGILSCRPAFIQKFATIKVFVFLLSFLVTVQQALSSGYINSVITTIEKRFEIPSSLSGLIASSYEIGNVITVIFVSYLGSRRHIPVWIAIGAVIMGLGSMIFMIPHFVAEPNLTTASNNSSSDNICRVVSLREQDMGLGRLSSGLSSPPLAPHNNLRGDNCIQGSPSTAGPVMLFVLAQLLLGCGGSPLFTLGTTYIDDHVRPESASLYIDIPRSMWRLVCNPVYVVTCLGACMELVIVSGFVVFLPKYLETQFSLGKSQASIFTGSIAIPGACIGIFFGGCLLKRLELRPKGAVQFVLVSNIICLTCYGLLFFLGCDNVKMAGTTIPYFNSSTKGPEPFQVNLTASCNFGCECRMNDVEPVCGNNGLTYFSPCHAGCTDFSSKSNFTNCACIHGNLAIPRLPAEVTAIPVATSGPCTSPCKTIFPFLILLFFMTFVVAVTQMPLLMIVLRSVGEEERSFALGMQFVIFRLFGYIPAPILFGNLIDSTCLLWKSTCGEKGGRCLLYDIEQFRYRYVGLCAGIKILALALFLVDWWLVRRRHQLEESPKGLTVNDIVGSIISLDKLFEEKPQHLNLAENDAMTQNSTEHTPSSISSPTEQTKSTNLEESESTHLTQGSMDTTNHSKLLADFSDTRQDDDVEFRPLNSKFESNDRHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MP92</accession>
    <name>A0A8J2MP92_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similar to spop: Speckle-type POZ protein (Xenopus tropicalis)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS10510</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5101608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MP92"/>
    <dbReference type="OrthoDB" id="7555121at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="21"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5101608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="73" mass="8581" checksum="25CC335F39B3F90F" modified="2022-05-25" version="1">MENKDDYFISNDILTLCVELSIHPVILNKMLQFIYTGQVSEIDKDSEELFKVADMYQLDKLKILCVFTRLYAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MQB3</accession>
    <name>A0A8J2MQB3_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS5277</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5089538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MQB3"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5089538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="189" mass="21008" checksum="6D2B48F92F4590FB" modified="2022-05-25" version="1">MLASCSLDRPPCPSLLSGATARPAIRDLGRPRRTTSGGALERLLAAQLAIRRYRSLHRHLKRDLLVRVPEMSPRDRSPKLVLKSSVTWNRTLCHKWYSVHTGSFTLSLSTPVYRGGLSRKPVYDINDQFRLCMNYLDAGSRQLPIRGKNSSMMPVSGHTVLGKTSGLIGWAVSTGPEKKKNPKCQQDTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MQC2</accession>
    <name>A0A8J2MQC2_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">glycerol kinase</fullName>
            <ecNumber evidence="3">2.7.1.30</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">ATP:glycerol 3-phosphotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">HICCMSTLAB_LOCUS10421</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="pathway">
        <text evidence="1">Polyol metabolism; glycerol degradation via glycerol kinase pathway; sn-glycerol 3-phosphate from glycerol: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the FGGY kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.30" evidence="3"/>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5101348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MQC2"/>
    <dbReference type="OrthoDB" id="5422795at2759"/>
    <dbReference type="UniPathway" id="UPA00618">
        <property type="reaction ID" value="UER00672"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004370">
        <property type="term" value="F:glycerol kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019563">
        <property type="term" value="P:glycerol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046167">
        <property type="term" value="P:glycerol-3-phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006641">
        <property type="term" value="P:triglyceride metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07792">
        <property type="entry name" value="ASKHA_NBD_FGGY_GK1-3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000108">
        <property type="entry name" value="Glycerol kinase, glycosomal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000577">
        <property type="entry name" value="Carb_kinase_FGGY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018483">
        <property type="entry name" value="Carb_kinase_FGGY_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018485">
        <property type="entry name" value="FGGY_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018484">
        <property type="entry name" value="FGGY_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042018">
        <property type="entry name" value="GK1-3_metazoan-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10196:SF40">
        <property type="entry name" value="GLYCEROL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10196">
        <property type="entry name" value="SUGAR KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02782">
        <property type="entry name" value="FGGY_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00370">
        <property type="entry name" value="FGGY_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000538">
        <property type="entry name" value="GlpK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00933">
        <property type="entry name" value="FGGY_KINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00445">
        <property type="entry name" value="FGGY_KINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0319">Glycerol metabolism</keyword>
    <keyword evidence="6 10 15" id="KW-0418">Kinase</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="541"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="domain" description="Carbohydrate kinase FGGY N-terminal" evidence="13">
        <location>
            <begin position="65"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="Carbohydrate kinase FGGY N-terminal" evidence="13">
        <location>
            <begin position="153"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="domain" description="Carbohydrate kinase FGGY C-terminal" evidence="14">
        <location>
            <begin position="293"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00043149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CAG5101348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="567" mass="62651" checksum="D5DBB6111277829F" modified="2022-05-25" version="1">MEPRDDVEEEVQDDAFDESQSLSSPAVELSRDKKGLKRKTSIFKYYSFKSTEALPGSTKKSGPLVGVIDVGTRTVRFVIFTAKRVSEVASHSIDIEQLSPQEGWTEQDPKEILFAVKACIKDVVKKLEGIGGSASDIVTVGLTNARETTFPLCGLPVSPYFSALKIRWLKQNVSTVRKAIRDKRCKVGTLDTWIIWNLTGGKEGGLYITDVTNASRTMLMNIETLNWDPTLCRYFDIDMGLLPEIKSCSEVYGKITVGPLSGIPISGILGNQQAALVGQNCLKQGQAKNTYRSGCFLLCNTGTTRVYSSHGLVTTVAYKLGPNSPAVYALEGSVAVAGAAIKWLRDNMKLIKDVHESEQIAEKVFSTGDVYFVPAFNGLYAPYWRKDARGIICGLTAFTTKQHIIRASLEAVCFQSRDIIEAMFKDCGFPLTKLHTDGKMSTNNLLMQLQADLSGIPVFRSTMPDITALGAAIAAGQAQGVEVWPLDGDETETVPNDTFLPTTTPEERDGRYKKWKMAVQRSMGWAATKITAQMTDERYRVLASIPVSWFVMTSFVLLRLSYHFKER</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MQI3</accession>
    <name>A0A8J2MQI3_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HICCMSTLAB_LOCUS11330</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. Pelle subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5103079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MQI3"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08307">
        <property type="entry name" value="Death_Pelle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14066">
        <property type="entry name" value="STKc_IRAK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000754">
        <property type="entry name" value="Interleukin-1 receptor-associated kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.533.10">
        <property type="entry name" value="Death Domain, Fas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011029">
        <property type="entry name" value="DEATH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037924">
        <property type="entry name" value="Pelle_death"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR27001">
        <property type="entry name" value="OS01G0253100 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR27001:SF931">
        <property type="entry name" value="OS11G0664100 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47986">
        <property type="entry name" value="DEATH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="226"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="254"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAG5103079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="502" mass="57847" checksum="65A31F7D41CE88B7" modified="2022-05-25" version="1">MSSTPIWEKCKYIYNLPYNARVELCNILNQNDKWEELAGKWMQYDLLAIQNLRREKNPADELLSLWSIHNHTNLELFILLQRMQHYRAMGVLKPFIENKYHCLLEKGEGNLQFAIKNEKYTQPVNELKIDTQNFDRRMYHSPTPPKIVLKNYNNKIINQIGRINLLETAPSDSNNLLAGSSSVPSRISPILGCIGTSQKLNGLSLKTEISLPQIPYEELTRATDNWNQHKILGKGGFGTVYRGIWKNTDVAIKKIERRGPESDDSYIIQLQQSLREIAILNSRPHDNILSIYAFSIGGQAPCLVYQFMKNGSLEDWISLRRRSPPLTWLQRHEIIKGIARGLQYLHTIGERPLIHGDIKSANILLDKSFEPRIGDFGLAREGPIKDFMKVSKVHGTKPYLPEEFLRGKILSTKVDTYSYGIVCFELATGLPAYDHARIEHKFLKDFIDSWSDKDIFFLKDKKAGDESEKVFDNLILLGKWCSNRLAKDRPEMELVFKKLNSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MQX7</accession>
    <name>A0A8J2MQX7_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">DDB1- and CUL4-associated factor 7</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">WD repeat-containing protein 68</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">WD repeat-containing protein An11 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">HICCMSTLAB_LOCUS10709</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the WD repeat DCAF7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5101826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MQX7"/>
    <dbReference type="OrthoDB" id="24670at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000049">
        <property type="entry name" value="DDB1-and CUL4-associated factor 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045159">
        <property type="entry name" value="DCAF7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19919">
        <property type="entry name" value="WD REPEAT CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="6 14" id="KW-0853">WD repeat</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="332"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="14">
        <location>
            <begin position="265"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="16">
        <location>
            <position position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00060896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00071153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00075735"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00079586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CAG5101826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="370" mass="41512" checksum="2D2077AE93968871" modified="2022-05-25" version="1" fragment="single">MALHNVPPKRKEIYKYEAPWPLYSMNWSVRPDKRFRLALGSFVEEYNNKVQIVSLDEETSEFTAKSTFDHPYPTTKIMWIPDSKGLFPDLLATSGDYLRVWRAAEPETRLECVLNNNKNSDFCAPLTSFDWNEVDPNLIGTSSIDTTCTIWGLETGQVLGRVNMVTGHVKTQLIAHDKEVYDIAFSRAGGGRDMFASVGADGSVRMFDLRHLEHSTIIYEDPQHTPLLRLAWNKQDPNYLATVAMDACEVIILDVRVPCTPVARLNNHRASVNGIAWAPHSSCHICTAGDDHQALIWDIQQMPRAIEDPILAYTAAEGEVNQIQWGATQPDWIAIFSIISPTLTVGSGTLGSFWFVKILTYAARVKSQPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MR66</accession>
    <name>A0A8J2MR66_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Similar to T: Transposable element P transposase (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HICCMSTLAB_LOCUS8375</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5096767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MR66"/>
    <dbReference type="OrthoDB" id="7537987at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006612">
        <property type="entry name" value="THAP_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048365">
        <property type="entry name" value="TNP-like_RNaseH_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05485">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21787">
        <property type="entry name" value="TNP-like_RNaseH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50950">
        <property type="entry name" value="ZF_THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="THAP-type" evidence="7">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="91"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="675"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG5096767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="675" mass="76201" checksum="1B22380E6C89FA7A" modified="2022-05-25" version="1" fragment="single">IMGGCSFPNCHNSSEKGFKVMRFPRCIDIRNKWVTACKILKPINENSRLCEGHFRLEISPNENIQDCEEVFPGTSYHSNQPSDNFEKSPRELLLEQQINELLKENTALKKKVSHMAEKSTTLDTNLKKFLNPDQLLFLKSNASTNSKPWSEETIKKGLRIRLLMGTKAYKSLRDIEGFPLPAFSTLYSRLSGFNFAPGTFHSIIEWLGMKIRQQQDETAHYCVLALDEMSIHPAVEYDRGLGNFIGLVTPELARDSNEADTMASHAIAFVARGLTSHWKQLVGYALTGKSVTSKCLWNYVQEIIRELYQQDIIVKCISTDEGPTNVGMWTLNSITSSRYLINSSSQHPSNPDELLHWTSDVPHVLKRIWSQLLKTKFILSGPIVQANNLPSSEVDIAHVRQLVESQSLGGPVLVTGVTAAILDPSQFDKMHVGLAKKILSEEMGRALMFSAQTGYLPQEAMTTSWFILLCSQWYDLMVCRHKSHSLGSDESSLERVEFLQSFIESIKDLQFTTNNKWKPIQRGIILVTTTALNLRKDLVLSGKFQYLLTGCLTSSSVENLFSQIRAGGDIHPKPRQLRYRMRLVAVAQYLRVPSSASYEDDDEPYYLEFLKQKKDELRTTDDEKTLDAIEMPNSCVLSAIQEYGLYYLSGWAVFVSANGCEACETATISLEPLSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MRR1</accession>
    <name>A0A8J2MRR1_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Similar to RFC2: Replication factor C subunit 2 (Gallus gallus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HICCMSTLAB_LOCUS8649</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the activator 1 small subunits family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5097321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MRR1"/>
    <dbReference type="OrthoDB" id="4199794at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005663">
        <property type="term" value="C:DNA replication factor C complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003689">
        <property type="term" value="F:DNA clamp loader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18140">
        <property type="entry name" value="HLD_clamp_RFC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.272.10:FF:000006">
        <property type="entry name" value="Replication factor C subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000012">
        <property type="entry name" value="Replication factor C subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.272.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008921">
        <property type="entry name" value="DNA_pol3_clamp-load_cplx_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050238">
        <property type="entry name" value="DNA_Rep/Repair_Clamp_Loader"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013748">
        <property type="entry name" value="Rep_factorC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047854">
        <property type="entry name" value="RFC_lid"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11669">
        <property type="entry name" value="REPLICATION FACTOR C / DNA POLYMERASE III GAMMA-TAU SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11669:SF5">
        <property type="entry name" value="REPLICATION FACTOR C SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21960">
        <property type="entry name" value="RCF1-5-like_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08542">
        <property type="entry name" value="Rep_fac_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48019">
        <property type="entry name" value="post-AAA+ oligomerization domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0235">DNA replication</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Replication factor C C-terminal" evidence="5">
        <location>
            <begin position="113"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAG5097321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="206" mass="23184" checksum="E104717336ED90B5" modified="2022-05-25" version="1">MTEGAQQALRRTMEIFSHTTRFALACNTSEKIIEPIQSRCAMLRYGKLTDAQVLAKILQVCEKENVSYTNDGLEAVVFTAQGDMRQALNNLQSTFNGFGHVNSENVFKVCDEPHPLVIKEMLELCTQGKISKAYDVLSSLWKLGYSAEDLISNIFRVGKNLQIDETLKLDYIKEIGITHLDILDGINSLLQLNSLLARLCRRSLLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MSY6</accession>
    <name>A0A8J2MSY6_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">tRNA-uridine aminocarboxypropyltransferase 1</fullName>
            <ecNumber evidence="2">2.5.1.25</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">DTW domain-containing protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HICCMSTLAB_LOCUS13159</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the formation of 3-(3-amino-3-carboxypropyl)uridine (acp3U) at position 20 in the D-loop of several cytoplasmic tRNAs (acp3U(20)).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a uridine in tRNA + S-adenosyl-L-methionine = a 3-[(3S)-3-amino-3-carboxypropyl]uridine in tRNA + S-methyl-5'-thioadenosine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:62432"/>
            <dbReference type="Rhea" id="RHEA-COMP:13339"/>
            <dbReference type="Rhea" id="RHEA-COMP:16092"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17509"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:82930"/>
            <dbReference type="EC" id="2.5.1.25"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the TDD superfamily. DTWD1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.25" evidence="2"/>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5108281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MSY6"/>
    <dbReference type="OrthoDB" id="3173at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016432">
        <property type="term" value="F:tRNA-uridine aminocarboxypropyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005636">
        <property type="entry name" value="DTW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051521">
        <property type="entry name" value="tRNA_Mod/Golgi_Maint"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15627">
        <property type="entry name" value="NATURAL KILLER CELL-SPECIFIC ANTIGEN KLIP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15627:SF8">
        <property type="entry name" value="TRNA-URIDINE AMINOCARBOXYPROPYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03942">
        <property type="entry name" value="DTW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01144">
        <property type="entry name" value="DTW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="DTW" evidence="12">
        <location>
            <begin position="57"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00039242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00042508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM01144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAG5108281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="289" mass="34209" checksum="FE7D9F56D0020F72" modified="2022-05-25" version="1">MTETCKININNTKKLNELENKQRIIDKAPFDHLKIDDPSVLDDVQGREICGKCFKSRKFFCYTCYTPVIDSKYFPRVKVYCKVIFICIDIIKHRKEIEGKSTAIHAAILAPEDVTIYIYPDFPIFTPNDKVVLIFPGKNAISIDDLLSKRLNKENKSDDTETEDDYYPITRAIFIDSTWQQTKSIYKDPRLRELPCVVFSSRISQFWRHQKKSPRWYLATIEAVHTFLVELHTKTYGAIENYNIKQVNTDDEKYSGQYDNLLYIFKYMYHKIHTIYDHDQLRAYKRPLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MT38</accession>
    <name>A0A8J2MT38_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Similar to Rasgef1b: Ras-GEF domain-containing family member 1B (Mus musculus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HICCMSTLAB_LOCUS12343</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5106605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MT38"/>
    <dbReference type="OrthoDB" id="20825at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007265">
        <property type="term" value="P:Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00155">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06224">
        <property type="entry name" value="REM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.840.10">
        <property type="entry name" value="Ras guanine-nucleotide exchange factors catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.870.10">
        <property type="entry name" value="Son of sevenless (SoS) protein Chain: S domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008937">
        <property type="entry name" value="Ras-like_GEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000651">
        <property type="entry name" value="Ras-like_Gua-exchang_fac_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019804">
        <property type="entry name" value="Ras_G-nucl-exch_fac_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023578">
        <property type="entry name" value="Ras_GEF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001895">
        <property type="entry name" value="RASGEF_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036964">
        <property type="entry name" value="RASGEF_cat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113:SF356">
        <property type="entry name" value="FI05912P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113">
        <property type="entry name" value="GUANINE NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00617">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00618">
        <property type="entry name" value="RasGEF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00147">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00229">
        <property type="entry name" value="RasGEFN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48366">
        <property type="entry name" value="Ras GEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00720">
        <property type="entry name" value="RASGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50009">
        <property type="entry name" value="RASGEF_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50212">
        <property type="entry name" value="RASGEF_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-terminal Ras-GEF" evidence="4">
        <location>
            <begin position="62"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-GEF" evidence="3">
        <location>
            <begin position="223"/>
            <end position="469"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAG5106605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="498" mass="56092" checksum="CC4CE6037E7ECBAE" modified="2022-05-25" version="1">MTADFFPLQSLPQTPAGGVGGKGLGSGCGAGTGPGMVNGAAVDHQDIRDGVAINTEHALVYRDGNLVSGSLEALVQHMVPTEDYYPDRAYLFAFLLSARLFIKPHELLGEVCALCEHQQNLNGEGGKERLQRFVPRLVQLLAEWTETFPYDFRDERVMGHVRSITQKVAAVDAAARQEVSALLQNLLLRLTALERYEEGLSRLATEAATEQLTQVDVTELCPSATVLAQQLTHVELERLSYIGPEEFVQAFAKESPHLETSFKDMKKTRNLESYVQWFNRLSYFVATEVCKHAKKKQRVRVVEYWIETARECFNIGNFNSLMAIIAGLNMSPISRLKKTWSKVQSAKFSILEHQMDPSSNFSSYRSTLKAAMWRSVGATDERQRIVVPFFSLLVKDLYFLNEGCSNKLPNGHINFEKFWQLAKQVTEFIAWKQVACPFEKNSRVIAFLQASPVLTENALALASFECEPPDNNPEKERYKALKSDLNAQQNNIHEYIKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MTS2</accession>
    <name>A0A8J2MTS2_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Innexin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">inx</name>
        <name evidence="13" type="ORF">HICCMSTLAB_LOCUS7610</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Structural component of the gap junctions.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell junction</location>
            <location evidence="1">Gap junction</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 12">Cell membrane</location>
            <topology evidence="2 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the pannexin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5095240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MTS2"/>
    <dbReference type="OrthoDB" id="5867527at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005921">
        <property type="term" value="C:gap junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005243">
        <property type="term" value="F:gap junction channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034220">
        <property type="term" value="P:monoatomic ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000990">
        <property type="entry name" value="Innexin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11893">
        <property type="entry name" value="INNEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11893:SF40">
        <property type="entry name" value="INNEXIN SHAKING-B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00876">
        <property type="entry name" value="Innexin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01262">
        <property type="entry name" value="INNEXIN"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51013">
        <property type="entry name" value="PANNEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0965">Cell junction</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0303">Gap junction</keyword>
    <keyword evidence="11 12" id="KW-0407">Ion channel</keyword>
    <keyword evidence="9 12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="241"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="311"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="400"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004610"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU010713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAG5095240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="492" mass="57271" checksum="E7C6B6BED7F8BCBD" modified="2022-05-25" version="1">MLDIFRGLKSLIKSSNIHTDTSVFRLHYRFTVIGLIACSLIVTTRQYVGNPIDCIHSKDLPEDVLNTYCWIHSTYTIVSAYKKKGGVEVAFPGVDNSRLYPESERKEYRGRGDELDKPIKMPIMLKMIDIFGSLRSLFKVRKTEEDTLIFRLHYRVTVALLLAGCLTLACKSISGSPIHCEGSSAVETTVLETFCWLHTTYSMINAFNLTVGRAVPYPGLTNSKTDVHVNDNHPLVKHHKYYQWVIFALLLQAILFYTPRWLWKGWEGGKIHALMMDLDIGLCSEVEKKQKKKMLLDYLWENLRYHNWWAYRYYLCEVLALVNVIGQMFLMDRFFDGAFLTFGIDVLRFLESDQEDRIDPMIYVFPRMTKCTFYKYGVSGEVERHDAVCILPLNVVNEKIYVFLWFWFLLLGILSLLTVIYRVSILVINYLKRDAVETIVRRSKVGDWFLLYMLGENLDTIIYRDVMHELANKLSTRHHHNVSTIKGELQEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MUW1</accession>
    <name>A0A8J2MUW1_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS8395</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5096807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MUW1"/>
    <dbReference type="OrthoDB" id="7617012at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5096807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="253" mass="28778" checksum="3E11FFDB5440B593" modified="2022-05-25" version="1" fragment="single">MSLTPNQNISLTDALSFFPKFEGNPSELIDFLNCCKEAKSVLPEAAEGNLTKLIYGSKLGAKVKTSLNIAVPVTIAGLTSELKKIYVPNKTLFQLQGELGRMYQKDTESVVEFVNRLRKKGREIMDGEKFPFRQANRVENGVMYIPPRSESTFFIEVQNPEVREGFIPKLRICKGVFAGNCLVRINNMNRAYLQIYNTTEEEVAVKIPNLAVREIEQVMTLDLSSKNPYNRLSITKPIFNNNQNIPDFDRFER</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MWA4</accession>
    <name>A0A8J2MWA4_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS9653</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5100580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MWA4"/>
    <dbReference type="OrthoDB" id="7648950at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5100580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="256" mass="30202" checksum="D0BCA42E3C4BC676" modified="2022-05-25" version="1">MFYYRGIKYNDGTVPIELIIQSNTKISILREHILSEEVDDETVDYPLVDLANCFQHLNKKIRLQLYIKTNFDIIRNKKTNINSCCGSLVDKFKWKIEARIINFEIPFTNHFTKGQHVEVIGIIDISYQNEDDNDYPVVQINECYQYLREKIRLQGYIKTNFDIVKNRIDNTSTCQGSLANKLKFKLEAKIIHFELPFINRFNKGDHVEVIGVVKKIFNSLVTLTQNIPEQRFFECPTVRRVADKTSKTRITFKRFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MYH8</accession>
    <name>A0A8J2MYH8_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Similar to calA: Calmodulin (Dictyostelium discoideum)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HICCMSTLAB_LOCUS11634</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5103687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MYH8"/>
    <dbReference type="OrthoDB" id="26525at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016460">
        <property type="term" value="C:myosin II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000178">
        <property type="entry name" value="Calmodulin-2 A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050230">
        <property type="entry name" value="CALM/Myosin/TropC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048:SF0">
        <property type="entry name" value="CALMODULIN LIKE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048">
        <property type="entry name" value="MYOSIN LIGHT CHAIN 1, 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0106">Calcium</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="117"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="153"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="17"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAG5103687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="242" mass="26823" checksum="78C14D6E9F1A9E9B" modified="2022-05-25" version="1" fragment="single">TDGGSGGDEEPGSCSSRPSISETSWADAQKPSVPNEFTSTLTSIRQQFPFGDDTDKIISTEKQETLEEPRHDKCLLRADCPVQAIEVTGCEPTTDTKMEPLIISTASSSSSVSGQTRLPTKFEEAFNLFDKDRDGSITKEELGRVMRGLGQFARTEELRTMLEEIDTDGDGNVSLVEFVKIVSDIGNANAAQQTNLTQEQQEEQELRDAFRVSLSFCSVYLLIIRNFVAWVPNLRLRENCVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MYU9</accession>
    <name>A0A8J2MYU9_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Pericentriolar material 1 protein C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS12026</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5104486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MYU9"/>
    <dbReference type="OrthoDB" id="2125770at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034451">
        <property type="term" value="C:centriolar satellite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034454">
        <property type="term" value="P:microtubule anchoring at centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905515">
        <property type="term" value="P:non-motile cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071539">
        <property type="term" value="P:protein localization to centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024138">
        <property type="entry name" value="Pericentriolar_Pcm1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14164:SF12">
        <property type="entry name" value="PERICENTRIOLAR MATERIAL 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14164">
        <property type="entry name" value="PERICENTRIOLAR MATERIAL 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="114"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="238"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="496"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="638"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="842"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="328"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="114"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="505"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="638"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="842"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="877"/>
            <end position="887"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5104486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="996" mass="111215" checksum="AFD5E715F9F736AC" modified="2022-05-25" version="1">MTPGVNDGPKNTGTLPKSNRRYDRNREIINSNQPSARTVYQSRTQHSNNLLDLQPVGNDRDTCTLRSTKNSNTRSISSRASLSYQDIADIVSLGGNRQYNNYTGEDCIQWQEMSQSVDSRAQSPPHTQPAKPMNVDKMPDRNQVESRLNQIRDYIRMTSTMMESLSLSSDPRAHTQHDKLVTMVEDLRDSERKLSKLLEEYRPIEELNHQPQYSSHMKRFSDLLDILISQERILVTNNNNSRNGEGAGGEESLESQLRRKMEASQRKLAELQEHQANLVGMQQQVRERLQEARQTQQALLLQENQALTGSSTPAWEGGNSERQLANDSEVLESETAALRGKLAALQNKKKQMDLLVAELQNVEMSDRASCSSGGSRNAERDKSVELETLKQQLDHLKNLMSEATRARDAYNAINQPEVDSNANDACCNENGQADDEAAAALSSSNSVDRNSEADDISVKFNNSKERLTVEQIQAVTRELKEQQLLLQAARAEIKPSVNRDGAATDWSSRRGSNSQHSHTSTPANIWHNSTTIDEANDQNGDNITAPDNLLDIGPQITAVDGLGNNWWNVPAPSVNPQQHVGTGSLEYYRQLLMSSQAQQLQMMSTTMQQCCQLLWAQQRELQAMRSSIVQIQQHLQINQNQNQSQIQPQSRVSNETRDNYSNLSRSTHHLGNVLDAALPPITDSLPGTSGNSSTVAAVHAAHVRNKRNREHGVDNISLNSLSSTETPYSLNLQLSSNLQIQDRETPATRNNNSYNDVATQPVDNFWDDGHLSFRSVPDSNEENYSLRHLSGEMRDVLLSLVTSNRTRPDYLVIILREIKAISEDHRLRPRLLRSLRALQDTQSANNPLNETTDQTASESCQSSDEDSDAGGQARPLLNTSNNNDHQSSLLNEFLMPSHAVGQVPHAQNMPALLVDHFEFEAAAQINETNTFPPPILTPGYNEDLAEADQSRPEASNNQQNSPENENVEIQENGNVQHLANLDIATLEADREIANLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2E0B4</accession>
    <name>A0A8J2E0B4_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS94</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030000595">
        <property type="protein sequence ID" value="CAG5071873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2E0B4"/>
    <dbReference type="OrthoDB" id="2229346at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00646">
        <property type="entry name" value="F-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5071873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="232" mass="26876" checksum="8B1D93021BC93557" modified="2022-05-25" version="1">MDFILPNHVLVEIFKGLRPIQLAKLRCVHSTWKNAIERLVPRWLELIRMTSTETKPWKYQLIQMMFPSMSSSEYVNLTEEQFKELFFSFLKWRKFPKNLNRGLNAQFPSFEGGNEASIFGDLHGDQLIYGGLKEGRLFCINIASGNFDHAFNIFENSSVGTISIELRKVDLIKIWAPRKFFSCMPNSAIALIRKLGKRLTRKAILFSGFFRSRYLSNELTDFDRTGGDRGGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2E987</accession>
    <name>A0A8J2E987_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">TIL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HICCMSTLAB_LOCUS700</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the serine protease inhibitor-like (TIL domain-containing) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001114">
        <property type="protein sequence ID" value="CAG5073928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2E987"/>
    <dbReference type="OrthoDB" id="6236007at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030414">
        <property type="term" value="F:peptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19941">
        <property type="entry name" value="TIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036084">
        <property type="entry name" value="Ser_inhib-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051368">
        <property type="entry name" value="SerProtInhib-TIL_Domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002919">
        <property type="entry name" value="TIL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23259:SF70">
        <property type="entry name" value="ACCESSORY GLAND PROTEIN ACP62F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23259">
        <property type="entry name" value="RIDDLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01826">
        <property type="entry name" value="TIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57567">
        <property type="entry name" value="Serine protease inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0646">Protease inhibitor</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TIL" evidence="4">
        <location>
            <begin position="7"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAG5073928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="135" mass="15436" checksum="36800092B0FBCB45" modified="2022-05-25" version="1" fragment="single">INGHHKCRENEELKRCGRICEQTCFNFVHKKLDCSHDEKQCSKKTEDCSCKQGYIRDESTGVCVRPNQCSRCDYGEDYLPCGKLCEVSCESQVVPKICNRAICGQSDCRCHFEAGFVRDHSTGRCTLRKNCARKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2EA55</accession>
    <name>A0A8J2EA55_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS349</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001114">
        <property type="protein sequence ID" value="CAG5073406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2EA55"/>
    <dbReference type="OrthoDB" id="10347156at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="184"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="184"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5073406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="247" mass="28301" checksum="2CCAC0AE23212FF2" modified="2022-05-25" version="1">MPIINELKKNVLSNSNSETFLSYLMNVWFSYPEKVLTWNILWDQQWIVEFFNQNLSRVLNYLQNQTLKQFITNIPVMLKETIKTLSQPEFTENRSQVTADEIPKKIVQFIHKLHNQISDEKLSIKFFYDGMIKNTLIQDTIEIASSRRPSVQIQSDIVNERTQMSSNIGNNVVAVESVISSQLRSESTTSLETGSTNNNSINENPSIVIHDDDSETEEPGSSMNTTLDDEIIVISDDGVTENNFTER</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2EAR2</accession>
    <name>A0A8J2EAR2_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Similar to Ski: Ski oncogene (Mus musculus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HICCMSTLAB_LOCUS583</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SKI family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001114">
        <property type="protein sequence ID" value="CAG5073745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2EAR2"/>
    <dbReference type="OrthoDB" id="3938623at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046332">
        <property type="term" value="F:SMAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030514">
        <property type="term" value="P:negative regulation of BMP signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21079">
        <property type="entry name" value="DHD_Ski_Sno"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.260.20:FF:000002">
        <property type="entry name" value="SKI-like oncogene a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.390.10">
        <property type="entry name" value="SAND domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.260.20">
        <property type="entry name" value="Ski"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014890">
        <property type="entry name" value="c-SKI_SMAD4-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010919">
        <property type="entry name" value="SAND-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003380">
        <property type="entry name" value="SKI/SNO/DAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037000">
        <property type="entry name" value="Ski_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023216">
        <property type="entry name" value="Tscrpt_reg_SKI_SnoN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10005">
        <property type="entry name" value="SKI ONCOGENE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10005:SF25">
        <property type="entry name" value="SNO ONCOGENE, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08782">
        <property type="entry name" value="c-SKI_SMAD_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02437">
        <property type="entry name" value="Ski_Sno_DHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01046">
        <property type="entry name" value="c-SKI_SMAD_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="Putative DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63763">
        <property type="entry name" value="SAND domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="c-SKI SMAD4-binding" evidence="3">
        <location>
            <begin position="255"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="531"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="728"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="594"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="611"/>
            <end position="636"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG5073745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="763" mass="86036" checksum="147A89D4FA4B5763" modified="2022-05-25" version="1">METLLPGHTTNQSYSPQLKTVLKTYQLSAVKSLQGPSSALLGMDCKNLLQEQFHFSSLRCSDTCEANPDKDSCKGKEFIRDRLDVVERLDREDSEDSQTERVKVDKRELEFQIPILTAPDQSCSERCETLLENERISCFVVGGERRLCLPQILNTVLQDFSLQQINQVCDELQIYCSRCTHDQLEELKLSGILPRNAPSCGLITQTDAERLVSALLLRTETRELHPEEVLLKHHREDKELGLCKKEELDDSIVRFKVYHECFGKCKGVFDADLFDSEDSACIECLECGGQFSPQRFVRHAHRPLENRTCHWGFDSTNWRSYLLLSRDQPHYNKVVSLFRNLKDRYPVPNYSKRKAPEIRHDIEKLPKRMKKELNRDDCGIYASNNGLMYPVSATGTDGDPYLMQWAVFELAARGASAFRPWNAAAAAASCKHRDNSPLVPAYLSRGPPVLQHPERVVSLSDCERFEPHYQPNVALAPVPTPSITPVPPSLSSGIPVPVVAPRRHYHDKRHHHRSLSPDDNNKLDTVVIKVEKPSSPAPEQDIVDNYQSSTPDPHDNDNNNPLGNDNNDNDIDKQDSVIVNDINHDISHTNDTADTDKAEEKSKTTDEEESSAVTSSTVNVEPTDSLSSASPSSASPELFDPSALVDLEERLVTLKVPQDVLTLAKKVTNEFRQLLLQRNNDFREIKRLKDQLNNFNHNHSCNNNSNNLLPSNDCNDIKADNDTNVVVDSTDTVDDPSNEFADSKEPESVLPKTLPTDNLVEKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2EAY2</accession>
    <name>A0A8J2EAY2_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similar to bbs9: Protein PTHB1 (Xenopus laevis)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS250</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001114">
        <property type="protein sequence ID" value="CAG5073262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2EAY2"/>
    <dbReference type="OrthoDB" id="10262646at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034464">
        <property type="term" value="C:BBSome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028073">
        <property type="entry name" value="PHTB1_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026511">
        <property type="entry name" value="PTHB1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20991">
        <property type="entry name" value="PARATHYROID HORMONE-RESPONSIVE B1 GENE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20991:SF0">
        <property type="entry name" value="PROTEIN PTHB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14727">
        <property type="entry name" value="PHTB1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PTHB1 N-terminal" evidence="1">
        <location>
            <begin position="1"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5073262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="195" mass="21953" checksum="2F2D054CEC039A9B" modified="2022-05-25" version="1">MSLFRTREWWRTECGGGEEVFDGQSLLVVPLFGDDRKDIIVVSSHSGFLRLYSPSSKWDEEKINPTGYQLTDLIVEGSQDLRLGILTPSKLLVYAVTFTPGSTEHGDRCILEVVYSHELPGFPASLTAGAFGGARGRDFFSVQCLDGTMLFYEQETHTFQQVLKDRLLPEQVAYVPRNDVFITSSPGWILECYRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2EB60</accession>
    <name>A0A8J2EB60_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Similar to brun: Protein brunelleschi (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HICCMSTLAB_LOCUS810</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001114">
        <property type="protein sequence ID" value="CAG5074038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2EB60"/>
    <dbReference type="OrthoDB" id="27962at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058565">
        <property type="entry name" value="Ig_TRAPPC9_Trs120_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058568">
        <property type="entry name" value="Ig_TRAPPC9_Trs120_4th"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058564">
        <property type="entry name" value="TPR_TRAPPC9_Trs120"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013935">
        <property type="entry name" value="Trs120_TRAPPC9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21512">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21512:SF5">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26254">
        <property type="entry name" value="Ig_TRAPPC9-Trs120_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26283">
        <property type="entry name" value="Ig_TRAPPC9-Trs120_4th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26251">
        <property type="entry name" value="TPR_TRAPPC9-Trs120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Trs120/TRAPPC9 TPR region" evidence="2">
        <location>
            <begin position="345"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="domain" description="Trs120/TRAPPC9 first Ig-like" evidence="3">
        <location>
            <begin position="514"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="domain" description="Trs120/TRAPPC9 fourth Ig-like" evidence="4">
        <location>
            <begin position="941"/>
            <end position="1034"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="249"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="764"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="764"/>
            <end position="788"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF26251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF26254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF26283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAG5074038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="1069" mass="119388" checksum="1445A131015F04BC" modified="2022-05-25" version="1">MSQPDYEQTTHDHASLLVLLKSIGTQLKPKLLSRLYERINKSLSKLNIVDSSGSTREIIIRFVRDYPVENIDWGDFQTHRRLLGLITFSKYDEQNEFSELCRLHETLKVKYNDTLYDSRAIFFGPVESDSINEPPTGFVPPPNFKTSAIYYADELCPSLESQILECLNALFWILESKRLKRLREKSDRASLLRAPFEKKELIGLDLDTAAASLQTVNDWLWLGAAYEGLCATSSMILYPNLRRSLTLHRNSSLQETSPGKRRESQSLPSPTNEEFPKTHIPHLLPPEEIAKKYREAIVHYSKYQNAAIVETEASFKATRISIEQNSPLQAACFLNNVVFNHINLSEQEKIERFTKLAELYSSFGFSRKASFCMRLAALRYVSPNNPNRDWKQCYNLLLQSTSGFKLSLDPAEMTDNNRKGWPKIQIQILNELIIAANQMGNAALATRHMTFILQTLFNYLSPNDRKDIALQLQGVAQQCEGAPVPLVLESGIVIPPANLINIPTTKEFKLKNLQAHLQPQKIERVKEDHGPFLFTPINFGSLERKNVSKNSVEFLWVDGDICEVLIQLINPLPFELVVSNMRLLTSGIVFESLPESITLPAMAGPIGVSLAGTPREPGTLEIHGFSTHTLGVKSNCRLRNIPGMPYPSYNITVIPALPKIDLATSLPQTASFSTGQNIVTSASVSLYGGESTECTITITNCGQVPIETVETSIKSSLSKIKEAKIFQWSDDNFNSQLPLLPGASASLTLYLFADMEFINNKDQVQKSSPRISNAHGSKSWPTRSNLTQSKKKPSSLPGNSGKNSGINSQLAKLTIQPPSNIIVEGQLMIKYSGGEGLTAGYCRVSSVFISIEMLPSVNITSWDVLPAETSSQFYLVLDVNNMTNQEMELYYTQSKCIYMGGRESCRIPVPVDRCPLDKLSTIESGDVDNELQKLCSQHTAALDEITCTIGECVSIGVGVCNALERPLSNLCLTIDFYQDYQNGTCNYKLDNLLAIAGASKVMLPTLQEYGRAYHECRVVFFMPGQFKLDIRCSSNHENSSSSSSSDKNLTIADNEWRYIPPIEITAEDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2EBI9</accession>
    <name>A0A8J2EBI9_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS1091</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001116">
        <property type="protein sequence ID" value="CAG5074858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2EBI9"/>
    <dbReference type="OrthoDB" id="7686884at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032062">
        <property type="entry name" value="DUF4803"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47890">
        <property type="entry name" value="LD24308P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47890:SF1">
        <property type="entry name" value="LD24308P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16061">
        <property type="entry name" value="DUF4803"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035194248" evidence="1">
        <location>
            <begin position="20"/>
            <end position="735"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5074858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="735" mass="83621" checksum="181E05D5E23A8EE2" modified="2022-05-25" version="1">MRVILSVTIVVLTFSWSNCLLEEFLRSDDLDPYAAFVSKVETKLKGNCVTEFPITNWQRRFTVGNTLKDMRKVMCKYDNVDNATNEFLWRSIIEKLDYYDMQAMQFNFELMHLMKKIGKYWTEIDKITKMSDFDTYLGFGCDHLSKYFQWRHNVDAELCNGDINKVYAQFVMTVKDKIKKYESKLNICDFKETLQKELMAFSQQGMKAHIQKYILTSYEVNVTNQCKNSCVNAELEALKDQFLKNVEAYKNLISKTMEEFTAYIKKCDAPKPMTPSFPGYSVNPCGGVNFPYMNPYNKKPPAPPAPPAPPSPAPYIELERAYQVKIVSEKEMDKTGSCSHNCDLSKVSINTGGECQGYTECKFISRKFDVCKAQNSKRRYDWVKDENDMIYGTPSACDNRTKSFSSMVDFWSLSPTSCDYCVCTCVSKPKHDPHTLTAVSFKEQTSDFYNNNNKVVVGLRFVKKDYMLHIQIAEARLLPYGKINASTFSWKPLENFEFNEQEQKFYIKSSSGSMKALSLGKDWGHASSINLDDVMAPKDYIVTGVRFRYAGDNLDCPVLQSGSLELQLQVRSLVFAEGHFFENNYPQWISAGKKDHCELVLYEPDNPMKAPMNSELSASTHFVRFQASDFRKDAGQSTVPFFDGFDVLGTPLVPLKGAGLFHRGAKGFGGFISLKVYDLNSKFYSIANVKKAPAAPAAPAPAGGDNLNELPFFKFVGNVIRTPLKIINNFMENMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2EBK8</accession>
    <name>A0A8J2EBK8_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Similar to Nep2: Neprilysin-2 (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HICCMSTLAB_LOCUS1955</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase M13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001116">
        <property type="protein sequence ID" value="CAG5075974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2EBK8"/>
    <dbReference type="OrthoDB" id="2016263at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1380.10">
        <property type="entry name" value="Neutral endopeptidase , domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000718">
        <property type="entry name" value="Peptidase_M13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018497">
        <property type="entry name" value="Peptidase_M13_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042089">
        <property type="entry name" value="Peptidase_M13_dom_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008753">
        <property type="entry name" value="Peptidase_M13_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733:SF167">
        <property type="entry name" value="FI17812P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733">
        <property type="entry name" value="ZINC METALLOPROTEASE FAMILY M13 NEPRILYSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01431">
        <property type="entry name" value="Peptidase_M13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05649">
        <property type="entry name" value="Peptidase_M13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51885">
        <property type="entry name" value="NEPRILYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M13 N-terminal" evidence="11">
        <location>
            <begin position="58"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M13 C-terminal" evidence="10">
        <location>
            <begin position="483"/>
            <end position="654"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF05649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAG5075974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="666" mass="77046" checksum="637B5AC97C9382EA" modified="2022-05-25" version="1">MTTSVPVIRCKGNQLWQDTVLGCIVGIFFIGTSVAGVVDNTQYITSRIINYRNTSYNPCENIYAFACGNYLKANVTPPIILQPSLVANDITDLIQNGGSHRELKPFKLIEDLYKTCMDDNAVGQEVLALLDRILKKLGNWPVFEDGRWKESDFDWIDFTIGSKKLGLDINYFLDLKPWRVMEFNKTVIAPAEFKDSSDPLVAAYAKYIQSVFALLKNKKNSSREISEIIEFERQVSKINLYNSKDIYTEKLTLEDLVKKWPTINWNELISNIILRNLKAPVKITEIFLWSSQAVSDFVDLVLKTPNHVKANYAVWKIIQKTIPHLTEKYRVLHREYCLVQKCENTTRAHSCVGVLKRHLAPAVNLLYAKSHHNSDSEALVTDIIRNMKDELVRMINESWMSQEAKQKNVEIVRNKEFVIGFKGKDDDWVKFYENLEIDTSNYLQALLDLELFAIENRFNETDFDGEAKKLFEEFLVSSLYGKIYIPWSSLRKPFFDVSYPLYVNYASIGSYIAYELIKSVDNLEDFTKDVENEKAACFRNQWSIIDNFNLNDHTSAPKIRMALNAQIVAQMGMKIAYLTYRRVAQSPKEEVPFQLTYTNHQLFWINLAQNFCQEDPQHEPKTIDHKYTSFEYFFSKAVTSAPEIYDDFNCSDKSFAKNYGTSCSYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2EG70</accession>
    <name>A0A8J2EG70_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS963</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001114">
        <property type="protein sequence ID" value="CAG5074209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2EG70"/>
    <dbReference type="OrthoDB" id="10280152at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="64"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="92"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="130"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="161"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="163"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="189"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5074209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="201" mass="22438" checksum="68B4D29D87D332A0" modified="2022-05-25" version="1">MVAVQDNRIVDSFCGMSLKVSLIFFGGVRIMGALGQLIIPVRNHIEDCDVNTDTTCRVISNNEFAANLSMSAFGILFVFMAILGSIMNNNKFLIASLAIDAIQLIILPFVSWYILSSYENHDYGAVVEPLVNYAYMGIIMVYMILAISRYEEIKSSKMYPFADESDDQEPGAESEDEKDLPKNGNVEGSFRETQEGKPEKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2EL14</accession>
    <name>A0A8J2EL14_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS2109</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001116">
        <property type="protein sequence ID" value="CAG5076128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2EL14"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5076128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="189" mass="20404" checksum="135EC8E5CCC21623" modified="2022-05-25" version="1">MRTFLEQGYFFRINYIQSFLFWLLFMRKGTRVEGLINYGSKFFEYTTTRTFGLLTDPPGEIDTRRFIKLKRGPLTGPITLFEIRVVKVSIEIRVVVRRVERRRTDAGGDDGGDEGGERGGHGRASGGTRGGTLTKVPRDGESAKASSTAGTGGTRAGEGSTCGSSIPATSRLVGGPWSQGSSSSSSHGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2EMK8</accession>
    <name>A0A8J2EMK8_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS847</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001114">
        <property type="protein sequence ID" value="CAG5074075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2EMK8"/>
    <dbReference type="OrthoDB" id="10333349at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="7"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="83"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5074075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="262" mass="30425" checksum="EB6D2A4C52BAB293" modified="2022-05-25" version="1">MVKKRSRKKLLDQINKTREEIEKKKEDSTSLKNLILKHNLYSDYLKKKTIIANNVILLKNKFKIVNKLQSILSCEGTMLPVNLNEWLTMLERLEKMSEELENEYVKSRATVSEDNCQLGDIVSRIDFPEDDLAVLLQDAFDKLGESMSHQNKIKQYARLPLSQQQQELEQSLLELEGMKCAGNFEDDNNNDYNWRGNKSKIEKVSGRKFDYYDVLFADRGKNSGKNSGNNSGLDDSGIGLEQKIDWFNDSIDEEQFERLKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H1E4</accession>
    <name>A0A8J2H1E4_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS420</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001114">
        <property type="protein sequence ID" value="CAG5073477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H1E4"/>
    <dbReference type="OrthoDB" id="7701227at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5073477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="189" mass="21550" checksum="F5DFE9A6060AA65A" modified="2022-05-25" version="1">MVDQILIDFEASVLEAEIKIAHWKCSQLVDTIKCIEEELLSLLPNSPDYVTNVLSLSPKFGVELDITEIPILTIFKDLEFGVSRIKVQGADAKELEVVKNNVRLRALNSIMNLYNSGGNKSKDRADFCLKKDLMNIRKFLSEHKDLLVMRPDKGDATVLMNEMEYKRAMNELVNDPALYKKVKTYPTNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H1F0</accession>
    <name>A0A8J2H1F0_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS451</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001114">
        <property type="protein sequence ID" value="CAG5073508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H1F0"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5073508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="167" mass="16434" checksum="1046F70A03787EC5" modified="2022-05-25" version="1">MAKVRTIARRVGTMGAKVVVGLESVVAFDEGAKDVIVVGSTVAFDGGPTDVVGVGSAVAFDGGATDVVGIGSTVAFDGGATEVGVRGAVAFVVGAKVGVGLVAIVGEVGLEVAVEDDVGTPEDAVIVLTVVGLVEEFGVVLIPSPHVTKRVVGGSVQQSPLLLDSHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H5Z6</accession>
    <name>A0A8J2H5Z6_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Similar to gtf3a: Transcription factor IIIA (Lithobates pipiens)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HICCMSTLAB_LOCUS2506</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001117">
        <property type="protein sequence ID" value="CAG5077584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H5Z6"/>
    <dbReference type="OrthoDB" id="2687452at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054599">
        <property type="entry name" value="TFIIIA_Zfn-C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051061">
        <property type="entry name" value="Zinc_finger_trans_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46179:SF13">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46179">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22110">
        <property type="entry name" value="TFIIIA_zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="42"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="103"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="131"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="157"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="185"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="212"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="242"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAG5077584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="338" mass="39837" checksum="CC2C9870004F85E9" modified="2022-05-25" version="1">MGLTSDSETESVTMKSKIDEMDLEPIVANNDESIITKNKKTHDCTVPGCKKSFNKPSRLLWHLRKHTGTVKTLQMCGICQLTLKNRTNLLKHHRRAHENKDRLSCKECGISFRKKYKYDEHMNRFHDGKLFKCNQCDREFKNLLKLKRHEKAHDVKYECTVENCKMIFDTYMEFRQHAKTHPKEHTCDKCNKKFLLKQELNKHLKTHEGKLLSCPYEDCHKTYALLNQLKVHIKAKHKNLKFECDLCKVTFPYKISLRKHIQRVHLNINVSKPKVYKKGEERKRRKDIGKQTRSMPSILAGVLLPPSVEKMVMNRETNIKLSDTNFESIEDDMIDNQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H5Z8</accession>
    <name>A0A8J2H5Z8_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Similar to Mxd1: Max dimerization protein 1 (Mus musculus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HICCMSTLAB_LOCUS2512</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001117">
        <property type="protein sequence ID" value="CAG5077610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H5Z8"/>
    <dbReference type="OrthoDB" id="5920083at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11401">
        <property type="entry name" value="bHLHzip_Mad"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11969:SF54">
        <property type="entry name" value="MAD-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11969">
        <property type="entry name" value="MAX DIMERIZATION, MAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="8">
        <location>
            <begin position="38"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="176"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="87"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="176"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAG5077610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="249" mass="26850" checksum="0E3407F4D4B69B1E" modified="2022-05-25" version="1">MSIAALLQAAEYIERREREAEHGYASTMPIPDDLRALAKRSKTKKSQGSRRAHLRNCLEKLKVLVPLGAETSRHTTLGLLTKAKRFIKSLEDRERKHAAHKEQLAREHRYLRRRFEQLTGQPSTLATLRGFPGLEGNTYGLSTSAPSTSSCSSAAAVAAAAAAALISKRRSVSECSVTTVSSTGSASSSRNSDRSTGSPSISESDEVDVIGYTSNQSDTDDHSSVQSSSDSGVAMSTSRLTLSEMMDNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H605</accession>
    <name>A0A8J2H605_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Similar to p: Hermansky-Pudlak syndrome 5 protein homolog (Drosophila pseudoobscura pseudoobscura)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HICCMSTLAB_LOCUS2528</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001117">
        <property type="protein sequence ID" value="CAG5077674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H605"/>
    <dbReference type="OrthoDB" id="19493at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048066">
        <property type="term" value="P:developmental pigmentation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056499">
        <property type="entry name" value="Beta-prop_HPS5-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23287:SF18">
        <property type="entry name" value="BLOC-2 COMPLEX MEMBER HPS5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23287">
        <property type="entry name" value="RUBY-EYE2-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23756">
        <property type="entry name" value="Beta-prop_HPS5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="1 3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="4">
        <location>
            <begin position="843"/>
            <end position="886"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAG5077674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="886" mass="101589" checksum="BD0445952F967987" modified="2022-05-25" version="1">MQSSFILSEYEDINVLLLKPIAATQRIKYTCFNVSTSYIALGSTSGSIYLFTREPCTFQQVIPLSEGPVTHVLLSPDEKNLALSTKRGSVCVINIKPIKLISIISNEHIDTVITCLCWNDRSSEIYVGDNNGKVSTIVLSIFTVNGMFPAPSCALMHLDSSVVQMDYSSHYLLVSTLSRCYICNTSQEQFKQIGNKSRDGEYGGCFFKSEQSKPHYNSSIMSNSSEVDTTSDRVPKSIGSMIGLNEESDENLVIYCTRPGCRLWEVNVFGTVVKTHQFKEALQPPSKIFKSSSIKSNCDNTSSNTQTQTINFSRLKIINKKYLLSYTGNNIFIIDPISTTILSTEFNNIFMIDIIEDRVYIMTTLGTFHSLLLSTPDYLILKLYECKLLEDCLQLCKLYRSDFTNGSDNDINVITPIIASIQSNFTPQRLNSGIVVVNSGHGFLNDDYNNYVLDNDNEKCSREHPELPDNSDEIIFTNRLENMKISNGDKNKESRDENLESLFKNELTSIQTDVEPIYELINSLKSSLNEEIIKKILDSIARIKTKYDIVELNQFIYEIIRSVERHYFTVLLESIVMIDLFVENNFVIDEITRAFIDFNSGTRCICERERESSGDTEPKFMEVGINLLKFDKNKGIYLCSKVPWMWEEYFRIYYYLERDIIPLCLQSRDNNGIANLFTLIEEKEEEEFWEYAAENYKIMEKGICLICKKSADRDDQREVIDWSEITRLIIKKKNIYAAVKFVKHLEQLLLHVKLKERQTFFFFSVYQTIIFTKLLDRHGLEHTVEFDRNKLTNEYNSICSSEAKKILKESLEKDLEKQLVNKNLFGSGVYHWGIKFKTKSSICSSCTLSLQTPVLLGNNGISIFPCGHAYHVNCLLQKKSTKCLLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H618</accession>
    <name>A0A8J2H618_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS2551</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001117">
        <property type="protein sequence ID" value="CAG5077760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H618"/>
    <dbReference type="OrthoDB" id="7659010at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035173665" evidence="1">
        <location>
            <begin position="18"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5077760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="297" mass="33573" checksum="73B6905F6F9077B6" modified="2022-05-25" version="1">MRLHFFIFICVVNSVFAQLPNEDDKHGIGNVQHEETPCGIEALIYGGVGYTNTRPGPLFDDEYLPTCSCYQNLFESQRNYIYEDLKLYKASSGSGGYGEFQGFGGGDITLPGVNCIDNDRKPITGPERSGITYQVNLNRTVMTVKENEYFTAGPEGNNKNGYNYIEFSKTVDEDSTFKLGKVSLKNGKKLIFDSSDHVDQDSMKDICEKHTPRSIEDNLMKILRAGIFNDSECPIMEGSNFTAPNSIDPFLMTFNQKMNCGYYLLNYQIDTPDTDDALALYYIFEIKEDEDCLKEEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H656</accession>
    <name>A0A8J2H656_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to pol: RNA-directed DNA polymerase from mobile element jockey (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS2625</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001117">
        <property type="protein sequence ID" value="CAG5078030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H656"/>
    <dbReference type="OrthoDB" id="7696036at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33332">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14529">
        <property type="entry name" value="Exo_endo_phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="2">
        <location>
            <begin position="48"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="466"/>
            <end position="599"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5078030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="634" mass="73318" checksum="9A4B6A0D97229311" modified="2022-05-25" version="1">MPIFSFCKTDRPNSKQGGGTAIIIRKGNEIIEYTILKINTNDNSNTNIFIISLYATNSNKIIFLKELDIIFNKLKLNQTNNRFIIAGDFNARRMEWGDHADNERGRYLRRWEYTTANHYNAKIYPTHIPSRTDSNTYLDICITDLQITDLINNKLSTCEYDSDHLALTFTVKLPNRMEYIDRQQTLHRFNFKATKWGKFQHKLQSNYNTIIPDDKNLTIKEIDEFIEDINKSILTTIEETVPKFKPHNNLHKYINTRIKKLQKNKSRLITELHKLQTNNPSNHRKEIIRLKELIKLTKAELRKEFGTSSATYYANLLKEINHRDASTFFPKINRYLRRKNPISIGDQILNQNDPILIGIPAEKINRTENNTVIISDPTSKLEVIGMFLQSINSPRYLNNGTRIKEIVDKEATKIKNKLNDNHNNNTTFTKFTTENRSTLSKHEDEKEYFFCNSHSLNLILQRLPNKTSSGGLQQRTVNSPTLFSIYLSTLLSSFDLNKGDLKAIAFADDLVVYLPGKSPLKIQDGLQKLLNVIDEFMQTWNLRINYTKCETIVFRRSTHFLTKGSRSGLNTFTLKGTNPGTDTVVNIPHKSIVKYLGVYLDDKLRLNKHINIQLNKASAALKSQPKLILLQTLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H700</accession>
    <name>A0A8J2H700_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Similar to Uso1: General vesicular transport factor p115 (Mus musculus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HICCMSTLAB_LOCUS2842</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001117">
        <property type="protein sequence ID" value="CAG5078796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H700"/>
    <dbReference type="OrthoDB" id="198977at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012507">
        <property type="term" value="C:ER to Golgi transport vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005795">
        <property type="term" value="C:Golgi stack"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048211">
        <property type="term" value="P:Golgi vesicle docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045056">
        <property type="term" value="P:transcytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048280">
        <property type="term" value="P:vesicle fusion with Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041209">
        <property type="entry name" value="P115_Arm_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006955">
        <property type="entry name" value="Uso1_p115_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024095">
        <property type="entry name" value="Vesicle_P115"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006953">
        <property type="entry name" value="Vesicle_Uso1_P115_head"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10013">
        <property type="entry name" value="GENERAL VESICULAR TRANSPORT FACTOR P115"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10013:SF0">
        <property type="entry name" value="GENERAL VESICULAR TRANSPORT FACTOR P115"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18770">
        <property type="entry name" value="Arm_vescicular"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04871">
        <property type="entry name" value="Uso1_p115_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04869">
        <property type="entry name" value="Uso1_p115_head"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Vesicle tethering protein Uso1/P115-like head" evidence="11">
        <location>
            <begin position="254"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="domain" description="Uso1/p115-like vesicle tethering protein C-terminal" evidence="12">
        <location>
            <begin position="576"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="659"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="537"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="670"/>
            <end position="682"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF04869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF04871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAG5078796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="682" mass="75842" checksum="DA7F31CD1BF8ECBF" modified="2022-05-25" version="1">MEFFKNSFKSVLGAPDPENQPTGADTVLEMDRTDCEIVGLALDTLCNITSPETFDEEVDKNGPNSKIGEQFTEIFIKHQDSVGLVLAALEDFDFRVRWPALKLLSNLVSNRPKDIQEIILVMPMGVSKLMDLLSDSREVIRNDALLLLIQLTKGNANIQKIVAFENAFDRIFDVITQEGSAEGGIVVEDCLLLMLNLLKGNLSNQNFFKEGTCQRIMHACGLLQALCDILMASGVPADVLTETINAVAEVIRGNNTNQEFLGSVTAPSSPPRPAIVVLLMSMVNEKQPFQLRCAVLYCFQSFLYKNNDGQTQLIQTLLPQSNETPSLTTGQLLCGGLFSPDPLSNWFSAVALSHALIDNTTQKEQLLRVLLATNIGKPPVTLMQQCVFLLQQGSKPQSKLGLLILLCRWVSYCPVAVKTFLSLDSSVAYLTALLSGHDNNEDLEENLIQSMCALLLGMCVHFNDDQVPAYTKDKLCNLIDKRIGLERFQDAIGGTTRHEIYSRTLKHPQPSAKHPKDLLLDHEFCRLLKILEGGITIQDLQSQISNLRDQNLVLRAAQTNLADKDTLPNHQIKIDDSSEELQKSRSKIQDLESQLSEYKSMVVALQEKESQVSIELEKKLKETSEELEKLKKDQEDLLELLSDQDTKLMLYKQKLTALGEKVESDGSSGEVDDDTDDQPSSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H740</accession>
    <name>A0A8J2H740_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to HPS3: Hermansky-Pudlak syndrome 3 protein (Homo sapiens)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS3087</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5080722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H740"/>
    <dbReference type="OrthoDB" id="10255480at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017216">
        <property type="entry name" value="HPS3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029438">
        <property type="entry name" value="HPS3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029437">
        <property type="entry name" value="HPS3_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28633:SF1">
        <property type="entry name" value="BLOC-2 COMPLEX MEMBER HPS3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28633">
        <property type="entry name" value="HERMANSKY-PUDLAK SYNDROME 3 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14763">
        <property type="entry name" value="HPS3_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14761">
        <property type="entry name" value="HPS3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BLOC-2 complex member HPS3 N-terminal" evidence="1">
        <location>
            <begin position="6"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="BLOC-2 complex member HPS3 C-terminal" evidence="2">
        <location>
            <begin position="536"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="domain" description="BLOC-2 complex member HPS3 C-terminal" evidence="2">
        <location>
            <begin position="918"/>
            <end position="1054"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5080722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="1091" mass="124618" checksum="DA8BEFB7756280AD" modified="2022-05-25" version="1">MVRIIPVHNFLSQNVGQIEEPTASCTANLMDQDLLLLALSSHCVKVYGLASNQYKLLTIFPTVDLVQELVHSDKGNYVATLESKSSRDGAAVNNFVRVYINWEMTGNQNQAMRARIAGRVTPSLNRTLNSLEMIELPLNGQPTKIACCQTTGNLLVVMEDEAVIHELKVETQQTSKHKFLDFEVRPWSIRFTFSPTHVEFAEEFISVMNSWYFILIRLTNRFHDDNFISSDRVDKTNINNSKRRRSHPLKEVSVINNNNNCSEESKLKTRVDFNKSIINEREYIDWDQLVLNEPQETQRIKALGIVKEDNNLNVCFPSVKSDLSQSHYILDPPVIQATEISAVVTTRSYEDSWSENYIIEHLLRLKITEAPVQDGNEYFTCSILKPLYKRQKTSISNFKKSLLRSTKYNIFNGVTCLICTTQEGYLYNFLPNSSEEIFFDANCQIYPFTAPVIHVALENTALHALTEAGLESYTLRIQHLRSEEPPNDTPVSLIGLRPFLGVKKLLHASRCLVLLASDEDTWTFYSLNLPTAEDIYQDILTAANNHKTSPSTYKHLLAEANTVLKISKEMIYYTSDAAFFSSINDMSKSHLDNLYRQSCALLADFYMTSESPMDWGLSSWFYEVAGLKAHDVMARRDVQRAPGMVTFVSESLLNLQPGAEADTLFQEHNIVEILIKAEKSDLLKLILASPVLREYATDKLINVISNWEADDMTWLALVLLYTQAGRIHQAERALEPISDKFIAEKILSNWSWLFDVISAKKSNAMPIFSEFAGTLMRLKLRVFAQVLSKIVECKAVTLDEMIQIFLGYLPSRVGRDGRIAGNALQLCLETYLQSYHENFQCKKVDLAIVEAFKILVRSYLAELAQNGAKVCTNDTQVLFGSFRPRFLDNPLIYEKGKTNRKERTARVLREEFNESFKESIRLEVVKLQALLASGSLPEECYQEVQHFLETQKIEGSLSFKILCVRDTEKGIQLLADECPQALLDYAKVGFFIEDKYTEESDWKHFIQFLLKKMMDNQNNKNIYCIYDDLIRDTAIYIAQTMSMSGLKRILPNDSLNILQQYIDTSNQVVHADYIKTMIMGTGQHLLCNINF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H759</accession>
    <name>A0A8J2H759_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Similar to Scrt1: Transcriptional repressor scratch 1 (Mus musculus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">HICCMSTLAB_LOCUS3117</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the snail C2H2-type zinc-finger protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5080844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H759"/>
    <dbReference type="OrthoDB" id="5428132at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000322">
        <property type="entry name" value="GDNF-inducible zinc finger protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050527">
        <property type="entry name" value="Snail/Krueppel_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24388">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24388:SF100">
        <property type="entry name" value="ZINC FINGER PROTEIN 423"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="156"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="133"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="275"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="148"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00037948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CAG5080844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="311" mass="35075" checksum="CB2CC6407BA94630" modified="2022-05-25" version="1">MPRAFLITHRRYNGTEGFEDVGREVSLAAAAGTLIHPNNVIYHRSLSPRWTPGVENLHVYRSSPPESLHHINFHHNLNHRSENELSLHERTRLFFERIETEREILQDKTKARLSHLDESKNLSLPINQSLSPINLPARRISSGQSDTSKTDDNEDHECPDCGKKYSTSSNLARHRQTHRSLGDKKARRCPHCDKVYVSMPAFSMHVRTHNQGCKLPRPGFALEPMSTIIRHTKSQSAVSPPTPSAIQEENPAKIGASDSEYLSRMVIRTSVISQNPEHVPGRNKNVPFDFSDPTRPSAFSRPGITLNLAIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H7R3</accession>
    <name>A0A8J2H7R3_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS3627</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5082687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H7R3"/>
    <dbReference type="OrthoDB" id="7700765at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5082687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="377" mass="42445" checksum="7B985FB85EDE7937" modified="2022-05-25" version="1">MEIPSTRIFNCDETYVSLCPLSEKVLLAKGSRSAYKVVDSDKEGFTVLFMYSANVLKFALDATAQEKNAVISGFKAAGLYPFDPSAVDYDVFDKRKKSKTTVTKENVQDEVTEDKEKHLLTFETNLSKNILKEFNTAWLNQTLPKDLEITSLYKYRLDVSERSGSHEKSKPTVKEVTQEQPVNNLINDQASTPNDNNNTDMNLNDHSHSFNEEFLPLITNPEIDTSASSEVLYEFKVDNKPIEIVSQAQSGTDQSKNLNLLNLSDVLEHNIGDELIFESNVLDADNQTDFLDSTSAITTVSTAACTTPTIDKYSELQECQTFSQALKPMLGILLTTHLRCQLIIYRRKKRIKLESSGKPKLPSAGTSDQWMQYHSTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H7W9</accession>
    <name>A0A8J2H7W9_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to spopl: Speckle-type POZ protein-like (Xenopus laevis)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS3544</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5082373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H7W9"/>
    <dbReference type="OrthoDB" id="684045at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24413">
        <property type="entry name" value="SPECKLE-TYPE POZ PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="190"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="349"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="365"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5082373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="392" mass="45032" checksum="0A6D6F68B7D0BB17" modified="2022-05-25" version="1">MPLQKSNQPILKKIETWVVNNVDQYNFIDESVKDSVLTYDIHSGLDGTEKWVVKLIFYHKPKFVVRIGAVFKPVNEDEIKHHVEVTMYVLTSQNFYQPLDREIHRTDTGLINGVKIHTVLSNESIRKRLLKKKIEAPETIINNTITLRIELITYLDPEPMFLLNSLFRFMADVQQPDWILKLYETRNVSGDLTIKIQDNEFRAHKQVLDQRGFALNNATTNENNIFILSGISPEIFGMLLEFVYTGAIKKLDDFAEPLLEAADRFKLEDLKNLCEKSLLTENYVNYNNFADAYVLAKRCNARQLYGYARYMESVLSNIDCQRWSKNNPPTAEQLEKYLLPIKKIREAEKTSKSSTANPSDPVDVLNNSGSNFSTNDSNTTATAMSAFLIKIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H8F6</accession>
    <name>A0A8J2H8F6_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Similar to Rspry1: RING finger and SPRY domain-containing protein 1 (Mus musculus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HICCMSTLAB_LOCUS3554</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5082410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H8F6"/>
    <dbReference type="OrthoDB" id="10017393at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16566">
        <property type="entry name" value="RING-HC_RSPRY1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12883">
        <property type="entry name" value="SPRY_RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045129">
        <property type="entry name" value="RNF123/RKP/RSPRY1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035774">
        <property type="entry name" value="SPRY_RSPRY1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13363:SF6">
        <property type="entry name" value="RING FINGER AND SPRY DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13363">
        <property type="entry name" value="RING FINGER AND SRY DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13920">
        <property type="entry name" value="zf-C3HC4_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="B30.2/SPRY" evidence="7">
        <location>
            <begin position="236"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="465"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="9"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG5082410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="513" mass="57428" checksum="3BE1420FDF810D7B" modified="2022-05-25" version="1">MGACLCKDCPDGQENGNNENNEDTTVPSIDSHAAGDQSPDFKFPTSANIDKLVLETLGVIGGLVDNEQEPPPSMLKLHAIADKEEGWLQVASSMVNVIPMHSPLGASVITLLLDDCPLPSKETVLKLSHMFQVSQKTGKVQTSITQQRNICVVLGCIAEKLAGPSSIALLSKATLDYLVSNLRDVEPYVVLYSLIALEKFAQTSENKVTIQRRLMEEKEHPLLALEKWADETHYVRLLIEGRKYSHDTVDLTGINVMLNTKDVSEYLKISPNGLEARCDAYSFESVRCTFQVDSGVWYYETLIMTTGVMQIGWATKNSSFLNHEGYGIGDDSYSLSCDGCRRLIWYNARSEKFHDRPPWKAGDVLGCLLDLNKLEIIFYTNGVPLKPCVQVFKTARTGFFAAASFMSFQQCLFNFGNVPFKYPPADREFMKFNDHATLKPEDKVVLPRHIYLNQLRKLSVREDSCTLCYDQKASVRLLPCEHRGFCQTCPMQLVECPMCRATIEEVAVELDSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H907</accession>
    <name>A0A8J2H907_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS4620</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5087839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H907"/>
    <dbReference type="OrthoDB" id="535167at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5087839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="69" mass="7832" checksum="3E77B6AC24CBCF75" modified="2022-05-25" version="1">MPANDTKWVKFGDINNIVFLGKDIIALSSGYHILFVNLNTKYEKIEKFDNKDRGDGISSFSGHPTQKKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H974</accession>
    <name>A0A8J2H974_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">HAT C-terminal dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HICCMSTLAB_LOCUS3616</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5082644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H974"/>
    <dbReference type="OrthoDB" id="7684415at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008906">
        <property type="entry name" value="HATC_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052035">
        <property type="entry name" value="ZnF_BED_domain_contain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481:SF10">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05699">
        <property type="entry name" value="Dimer_Tnp_hAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="HAT C-terminal dimerisation" evidence="6">
        <location>
            <begin position="266"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF05699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAG5082644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="329" mass="38142" checksum="62164B86EA219C9D" modified="2022-05-25" version="1">MVHVFADELNGKCCKRNKWLANNNSRQERKYRRWKMEEAVEIAKTNYNKTIYAGVSDNAPVMTAMGKAVNLWHAGCSSHHGNLLAKDLIDKSFAESINTILRTFKASNLEREIIENGGTKIKLACETRWCSYRDAFRCCLKNLDMMKKIINFIVLSDSVCSLINKCQQSNFTIPDAAEEWMKLNVPIEDEKIQEIVQKRIDKVLTPILLAANLLHPHYQGKQFRHNDKYYSQAIEFIRNELNESYHEMEAYENKVGIFESLLKKGNIPPKLFWQMAENSYPVLSQLAQRLINIPSSSAQIERLFSNWSFVHSCLRNRLTPERSEKIMIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H9P4</accession>
    <name>A0A8J2H9P4_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Multiple epidermal growth factor-like domains protein 10 isoform</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HICCMSTLAB_LOCUS4547</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5087572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H9P4"/>
    <dbReference type="OrthoDB" id="18487at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005044">
        <property type="term" value="F:scavenger receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048513">
        <property type="term" value="P:animal organ development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048731">
        <property type="term" value="P:system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.300.10:FF:000002">
        <property type="entry name" value="Multiple epidermal growth factor-like domains 10"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.300.10:FF:000041">
        <property type="entry name" value="Tyrosine protein kinase receptor tie-1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.300.10">
        <property type="entry name" value="Tie2 ligand-binding domain superfamily"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013032">
        <property type="entry name" value="EGF-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011489">
        <property type="entry name" value="EMI_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002049">
        <property type="entry name" value="LE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042635">
        <property type="entry name" value="MEGF10/SREC1/2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24043:SF8">
        <property type="entry name" value="EGF-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24043">
        <property type="entry name" value="SCAVENGER RECEPTOR CLASS F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00053">
        <property type="entry name" value="EGF_laminin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12661">
        <property type="entry name" value="hEGF"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21795">
        <property type="entry name" value="JAG1-like_EGF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00011">
        <property type="entry name" value="EGFLAMININ"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="SMART" id="SM00180">
        <property type="entry name" value="EGF_Lam"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51041">
        <property type="entry name" value="EMI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1 5" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 8" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035285574" evidence="8">
        <location>
            <begin position="22"/>
            <end position="967"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="746"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="domain" description="EMI" evidence="10">
        <location>
            <begin position="25"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="9">
        <location>
            <begin position="187"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="9">
        <location>
            <begin position="225"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="9">
        <location>
            <begin position="316"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="9">
        <location>
            <begin position="405"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="9">
        <location>
            <begin position="491"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="9">
        <location>
            <begin position="604"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="9">
        <location>
            <begin position="652"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="935"/>
            <end position="967"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="207"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="250"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="336"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="425"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="511"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="634"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="677"/>
            <end position="686"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAG5087572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="967" mass="105639" checksum="F631D3A0A76FC8C0" modified="2022-05-25" version="1">MSSRVLLFALTLAAIVFTTLAALEGPNVCVRQEVYTVTVNVSEQKPYQVRENKWCFAVPPRCSSYRMEFKTVYKTELINRTRPVDECCKGYGQTKSGDRCVPICSQECVHGTCIMPDVCNCEKGYGGPFCDIQCPVGKWGKHCSKDCKCMNGATCDPFNGECKCTKGWMGDKCNQKCPPDHYGQDCGEECRCRNGGSCHHISGECHCAPGYTGPLCDDLCPEGRHGDDCKTECKCQNGGHCSPTDGNCSCTSGWIGEVCGNRCPDGFWGQNCTQECICYNGAACNHVTGECICKPGYRGHECFEVCPHDKWGLDCKNNCTCQNGAACLPNNGTCVCKPGWIGEQCEKRGCPDGRYGPNCQKVCECDESNTELCHPWTGNCVCKNGWDGPKCLRSCPFLYYGKGCEERCNCKNNAQCSPIDGTCICASGFHGTDCSEVCPDNMYGEDCTQKCACKHGASCAPDTGRCNCTAGWDGVLCDRPCPDGSFGKDCEDKCQCFNNAACDPQNGTCTCGAGYIGHHCEQKCSPGLFGQDCFHQCDCEEDNTQECNPTTGECSCKPLWRGVRCETRCPIGFYGEDCQTPCKCKNNGSCDPITGVCACARGWEGSDCSQPCKHGWYGARCKEKCPEKIHACQCRPGWQGERCQTPCAQGTFGVNCTQHCRCQNGGKCRANDGVCRCTPGWTGARCTDICPEGYYGDHCMEPCECKNDNFQCHPASGCICRHGYTGANCEEERISRNVQEKTESSVGSVVAGIFAAVIVIAATLAAWMYHRRRVANLKMEMVQVQYIAEPVTPPDRNHFDNPVYSCQPNSTRIDDAAMLLNNGVIRNNLGTKSTNSEKAKLGLGLPGNGACYADDDDDDSDSCRGAYGQYDHQASLKNKDADLGNPNVNVYHSIDEMDNKKGAEHLYDEIKQNNAELEYDHLDYTRPLGAWKPHYQRMANGFGPSRDESGSSRSGSTNPQDPEFGGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HA46</accession>
    <name>A0A8J2HA46_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Cc_K425_459</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS5435</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5089941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HA46"/>
    <dbReference type="OrthoDB" id="7647711at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5089941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="238" mass="28250" checksum="22CF0D261AEDF71C" modified="2022-05-25" version="1">MSAFFTDKSSDIVRYKQLDSNLRGYNLTEYVNVSTTKGDCFAHYFYATPINNQTLKLLKNNHVDRLACIYVNKRDNKVLFIRYDGLAKSFDDIRTVIYDYWTIKEANLMMNDNNNIDYYIEKINRDEITLIDTDKNSMDDYEYVGYAHWRYFDRGILYYGTRYLSDEGVVSALENDQTNRNKRDFLESFILYATVHESDVLWSRNQINDFVKHFHIQSENVTVVLPIDENEDDIVEDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HA93</accession>
    <name>A0A8J2HA93_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS5500</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5090139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HA93"/>
    <dbReference type="OrthoDB" id="6619045at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16148:SF14">
        <property type="entry name" value="MYND-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16148">
        <property type="entry name" value="NF-KAPPA-B-REPRESSING FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="844"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="208"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="739"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="64"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="208"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="739"/>
            <end position="767"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5090139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="874" mass="99776" checksum="645F1B2C8594E9F2" modified="2022-05-25" version="1">MNNSNRLTFKLTLGRVDANEQVGEPLDGAMSAAPTRGQSPRRQRRHRHRHRHHQHRRRHHHLKNNNNNNNNNHNNNHPHDNNDHDGAFHEQCRYSSDCPETQVDTLGVENCKQPYEEGETRPKVNPIFLWALQREQKIVEVRCEDYDKRNRIKLTKTPFGWRSIPRTSSSIYNSCRCSSGSNYSVNKDKPASSSPSITSSCVPCSMSLKSSSSSPSSYSESTSFSSRSSTSYMPSKSKDTCVVPEVRRKESKRCLAVRSHYHDRVSDDESDATRSSCRNSRISFDLSYDDHNHEEETDDRDDDYEERERFDDHDVHDGDYEYEDTQHENSKFLTLSCGRTTLGLIDLEEVQKDSLLQPRVVLEPLNPARYRFSSLIENSKLNDDIEMVVEDDEVVDQQIESVKDINKDNKSKNSTEGGKIDVNSVSVSVSVVRAEDTEEEIEEIEDDIKDNEELDDENATVFEYDDRDSVEMMDDEELHERDDDVLGPDDKLPETGFYQVARNVPTNKVPETCLEDDIVEEEIDEVQEDVKIINHKPRVPGSIPLPDLKPINDSLDKPRFPKTLQITRTCSQQVPPSPPCSVTCSEDASRPDLVRNVTPSVPEKRRREAPDLIEVKPTEWKRREAPKPANQLRELIRKSGGSIPDPLLVPRDRLSSLAAAPAIEIPRLLITRPELRLPEALSHPELLSDPDILVISLSHLQQVLDAVPDSRYRVPEDKNFKSDNRYQQGYQQQLYNHQHSYSSSNNNNNNNNNNNNNNNNKNQNSYSLLPTNSEKKRLSCKPIGSLMPAPMDLSRHSSSSVTPGQNSILRVRSGLLRQESEVTSTARIPGDDSRLWHPLFGCRYYYYSLSLLQLITVITGLSICLYNNLQSILL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HAK5</accession>
    <name>A0A8J2HAK5_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS5195</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5089328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HAK5"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5089328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="126" mass="14007" checksum="1D62F4FD543A63A5" modified="2022-05-25" version="1">MNIDLHDELVERISKMRRDHRLSLQSLGFNIVINISLGCPAYAVGGCQFSTVRHQEMAQFSIAAQCCEMQGRVGVLVLTGIDICSLEGITKHVGEDSSHSRQQSRSLFCWKPAKCGVLKIHGYLCE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HAT8</accession>
    <name>A0A8J2HAT8_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Similar to ZNF862: Zinc finger protein 862 (Homo sapiens)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS5703</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5090636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HAT8"/>
    <dbReference type="OrthoDB" id="7691576at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37162:SF1">
        <property type="entry name" value="BED-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37162">
        <property type="entry name" value="HAT FAMILY DIMERISATION DOMAINCONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5090636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="535" mass="61590" checksum="ABE2B009B5122363" modified="2022-05-25" version="1">MFEISVANLMGFPLQIRKNMQHKFRNEWLQDIQCKDWIVRKETSPGEFVASCKFCMCVVSKNNKYSDLKNHIETKKHKKRQNICSPMRQKTLPVMKKSIEKTKVCEAYISLFIAEHTSIATVDHLGQMMKKAVNDSDTIKDIHLHRTKCSNIIKNTLSPHFQETLKNDIGTGKFSLLLDESTDISISKYLGIVIIYYSSALKKIITTFLKLAELSSCDANGIISALKNTLTEFNLNYKNILGLGTDNASVVTGVNEGVYQKLKREILGLVLIRCVCVCVSFNSTSYMKSCRRKYAKEFRLHNFSNFSQSPGRRGDYKTLYKLINDNHEPAKIVQACQTRWLSIHSAADRILNQWVELKTHFDINRHEYVAEMLFNMYSDEINLALFLFLCPFLNELQRVNKAFEAQNADPCKLFQDLTTLIGFFVSKVVLQRTYTDPLTVDVENYLDPNPYLGSGFELKIIELKEKKAITEQQEKELRERCIKCLIKLAHELRSRLPDNVQILQKPNLLACQNVLKLNETKANFLKNCFEVTAIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HAZ1</accession>
    <name>A0A8J2HAZ1_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS5497</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5090130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HAZ1"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5090130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="114" mass="12956" checksum="F1A1D3CA30BDE683" modified="2022-05-25" version="1">MIKVNDLIKHYPEKRKLNTPELTRVSQRAVEKQVMEKSNERQVHGVNYVRPFGDLPREGDTVGDGSGLQPLLLPRRLPAPVFRRTIIFTSKTIHSCPLIHGTLNKPVAMKSTNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HBN2</accession>
    <name>A0A8J2HBN2_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS6088</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5092365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HBN2"/>
    <dbReference type="OrthoDB" id="7693256at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158457">
        <property type="entry name" value="Orange domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="103"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="109"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5092365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="210" mass="23267" checksum="7A05BA9FBB0E0FEC" modified="2022-05-25" version="1">MRDTSDMMEDAMSEDTMMDCGGYSGVSDLSDLTTDISDTSANIRVAAERLLNLLGIEDEDDDFLSSEDEGVELDIDDEDDDVIFSDDENNRLLQQLANSLAEELKASSHRQSSPPASSLAPLASSATRKYQSYHADLEDLELDYRSHKRLKVDNVQNSSPVCSWNTGWDACATEAVRYLMEEEGLAGHHPTVLALKNHLALQRNLSAYKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HBT3</accession>
    <name>A0A8J2HBT3_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Folliculin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">HICCMSTLAB_LOCUS4394</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell projection</location>
            <location evidence="2">Cilium</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
            <location evidence="4">Cytoskeleton</location>
            <location evidence="4">Microtubule organizing center</location>
            <location evidence="4">Centrosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Cytoskeleton</location>
            <location evidence="3">Spindle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
            <location evidence="5">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Lysosome membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the folliculin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5087001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HBT3"/>
    <dbReference type="OrthoDB" id="5599713at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005819">
        <property type="term" value="C:spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904263">
        <property type="term" value="P:positive regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12430">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1730">
        <property type="entry name" value="Folliculin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037521">
        <property type="entry name" value="FLCN/SMCR8_DENN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044886">
        <property type="entry name" value="FLCN_DENN_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021713">
        <property type="entry name" value="Folliculin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037520">
        <property type="entry name" value="Folliculin/SMCR8_longin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032035">
        <property type="entry name" value="Folliculin_DENN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31441:SF2">
        <property type="entry name" value="FOLLICULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31441">
        <property type="entry name" value="FOLLICULIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11704">
        <property type="entry name" value="Folliculin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16692">
        <property type="entry name" value="Folliculin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51834">
        <property type="entry name" value="DENN_FLCN_SMCR8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0966">Cell projection</keyword>
    <keyword evidence="10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="9" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="13" id="KW-0458">Lysosome</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDENN FLCN/SMCR8-type" evidence="17">
        <location>
            <begin position="65"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="191"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00004656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00009987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00021824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="CAG5087001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="510" mass="58022" checksum="347061151BA62414" modified="2022-05-25" version="1">MNAVIAMCTFCEIHGPRVIFTTQTYRSFTDEKESMKKLRFYGPKQVMQRSLNVSDDSKNECDGCRSLGNVKYLSNEHESRTSFLSARQPLTEDIQVLLGHACISIFRSLSCELHLGKDGICYFGDENRGHVLSHAFTLKDAQARGIRRSCSFIVFMKDKQFLLNMWPFFVDNLKQIIRELQDFAERKYNSDEAENPQRAARLLSARSDGSTGKKKTTPRGLCEITNEKHVFIRIHMWLVWILSAGARHLVEICPISNDLIESPLTYNYLARDLQGKLGRTTEGSTSAFLLRNEDFKPSPEFTEISKNKFATWILRNIKSYLTKEQFRQLLYSSLTGIQILVRGPEDKTLEALYALSSLVPRACRRIKLQGTEYKDINDFNFLGIDSSVAVPVCCSNICRLDIVSDKQRHELSSDTKPYVVKWSGVLPNKLPTLVNKLEKYLDNDKLDEVVLNKQLLVLQQEWANIAKIVHTMRGNGHRNDLTGLIVSLGAGLQDYSLLDSWSMGLPSNPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HBV9</accession>
    <name>A0A8J2HBV9_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">CUB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HICCMSTLAB_LOCUS6268</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5092636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HBV9"/>
    <dbReference type="OrthoDB" id="6344756at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.290">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000859">
        <property type="entry name" value="CUB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058698">
        <property type="entry name" value="CUB_metazoa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035914">
        <property type="entry name" value="Sperma_CUB_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33236:SF4">
        <property type="entry name" value="CUB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33236">
        <property type="entry name" value="INTRAFLAGELLAR TRANSPORT PROTEIN 122 FAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26080">
        <property type="entry name" value="CUB_animal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49854">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01180">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035247659" description="CUB domain-containing protein" evidence="4">
        <location>
            <begin position="21"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="5">
        <location>
            <begin position="105"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="291"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="291"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="164"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAG5092636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="418" mass="46817" checksum="AB8ECC55F8C834C2" modified="2022-05-25" version="1">MSRSTARISSWFTIIQLLVAESQQWSMFNMWPGFGQSPLEWSNHQNIQNQQIQPRVLNFFPVPVEEECRSEDQRRRGICMNTYECRIQQGKSHGPCALGFVTTGCGGEVINNLTYVVSPGFPNLVDQPLNCSVVIRKIESQVSQMRIDFIHFNIGQPNLRTGVCDEDVMEITSDVRTFQLCGWNSGQHMYVDVTDGPVTLNLRLPRNLQSRMWEMSITQLPFEQRAPAGCLQYFTEPRGTVKTLNYLPNGRYLANQDYLICMRQEKGSCSIAYFPCSNDSFRIGPSRFRRQTTMDNSTGTGAADQASLDDEGSGTGPVDDAIVDAAPIRRCVDRILIPCDFEEFITPGNDGAGICDMEHCGTSLCMTSEFDADGNCRVETSATPFNIRVAFGMGDQNNTYPVDMTGMCLNYEQLECAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HCE5</accession>
    <name>A0A8J2HCE5_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Similar to Cant1: Soluble calcium-activated nucleotidase 1 (Rattus norvegicus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HICCMSTLAB_LOCUS6758</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the apyrase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5093343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HCE5"/>
    <dbReference type="OrthoDB" id="25028at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004382">
        <property type="term" value="F:GDP phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045134">
        <property type="term" value="F:UDP phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030166">
        <property type="term" value="P:proteoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.100">
        <property type="entry name" value="Apyrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009283">
        <property type="entry name" value="Apyrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036258">
        <property type="entry name" value="Apyrase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13023">
        <property type="entry name" value="APYRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13023:SF3">
        <property type="entry name" value="SOLUBLE CALCIUM-ACTIVATED NUCLEOTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06079">
        <property type="entry name" value="Apyrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101887">
        <property type="entry name" value="Apyrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="6">
        <location>
            <position position="131"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="192"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="243"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR609283-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAG5093343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="248" mass="29148" checksum="E3DC14B5BD3C838D" modified="2022-05-25" version="1">MKSTSISAAEWPFLFLGLSRIIHLNIENIHWCTPDSNPVQCIDRKRRLAEEQLLKQTSKEPRPERKREKPRKWIRPDALIIRPAEKEKYAEILRRIKQSVPDEQVRTTVEKIHKTNTGDMLITLSSYMIHESGVWSNIHKCWFFIPRRCSVKQYNETEDEKMSCNVLLKADEEFNHVEVTQLNNWIPIRGFSSFKFLPGSEDKIIIALKTEEYQSQTATYITAFTINGKLLLPDLKIGDYKYEGFEFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HCU3</accession>
    <name>A0A8J2HCU3_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">2-(3-amino-3-carboxypropyl)histidine synthase subunit 1</fullName>
            <ecNumber evidence="4">2.5.1.108</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Diphthamide biosynthesis protein 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Diphtheria toxin resistance protein 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">S-adenosyl-L-methionine:L-histidine 3-amino-3-carboxypropyltransferase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">HICCMSTLAB_LOCUS4994</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-histidyl-[translation elongation factor 2] + S-adenosyl-L-methionine = 2-[(3S)-amino-3-carboxypropyl]-L-histidyl-[translation elongation factor 2] + S-methyl-5'-thioadenosine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:36783"/>
            <dbReference type="Rhea" id="RHEA-COMP:9748"/>
            <dbReference type="Rhea" id="RHEA-COMP:9749"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17509"/>
            <dbReference type="ChEBI" id="CHEBI:29979"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:73995"/>
            <dbReference type="EC" id="2.5.1.108"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; peptidyl-diphthamide biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DPH1/DPH2 family. DPH1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.108" evidence="4"/>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5088820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HCU3"/>
    <dbReference type="OrthoDB" id="1649088at2759"/>
    <dbReference type="UniPathway" id="UPA00559"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090560">
        <property type="term" value="F:2-(3-amino-3-carboxypropyl)histidine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017183">
        <property type="term" value="P:protein histidyl modification to diphthamide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11840:FF:000001">
        <property type="entry name" value="2-(3-amino-3-carboxypropyl)histidine synthase subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11850:FF:000001">
        <property type="entry name" value="2-(3-amino-3-carboxypropyl)histidine synthase subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11860:FF:000002">
        <property type="entry name" value="2-(3-amino-3-carboxypropyl)histidine synthase subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11840">
        <property type="entry name" value="Diphthamide synthesis DPH1/DPH2 domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11850">
        <property type="entry name" value="Diphthamide synthesis DPH1/DPH2 domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11860">
        <property type="entry name" value="Diphthamide synthesis DPH1/DPH2 domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016435">
        <property type="entry name" value="DPH1/DPH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042263">
        <property type="entry name" value="DPH1/DPH2_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042264">
        <property type="entry name" value="DPH1/DPH2_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042265">
        <property type="entry name" value="DPH1/DPH2_3"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00322">
        <property type="entry name" value="diphth2_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10762:SF1">
        <property type="entry name" value="2-(3-AMINO-3-CARBOXYPROPYL)HISTIDINE SYNTHASE SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10762">
        <property type="entry name" value="DIPHTHAMIDE BIOSYNTHESIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01866">
        <property type="entry name" value="Diphthamide_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01121">
        <property type="entry name" value="Diphthamide_biosynthesis"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00032">
        <property type="entry name" value="Radical_SAM_3-amino-3-carboxyp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00021915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00032574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00032789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CAG5088820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="454" mass="50492" checksum="B2990FA1005B8ED1" modified="2022-05-25" version="1">MSTEENSSVIVVKAKPVRKVYKAGAVRVNKIPQELLNDPILNAAIAALPENYNFEIHKTIWRIRELKAKRVALQMPEGLLLYATTIADIIQDFTEAEAVIMGDVTYGACCVDDFTARALNIDLLVHYGHSCLIPIDQTQGIKVLYIFVDIKIDTAHCIDCLKATLPVITKIALVSTIQFAGTLQVIAKEMRSAGYETTVPQSKPLSPGEILGCTAPQIRCADVLIYVGDGRFHLEAAMIANPKLQSYRYDPYEKKLSEEFYDHDTMRMVRQNAIENAKGGQTIGLILGTLGRQGNPKVLDSLEKRIITSGKKNVNILMSEIFPDKISMFSDIDAFIQIACPRLSIDWGTAFTKPFLTPYEGAVALNLSKYDLEKPYPMDFYASSSLGPWTPNHKPQELEKQSDACCGKYNFSIIGALQQKTSEESQNSPEGFVVRTSPVFPLLFFLLNKQTLHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HDF9</accession>
    <name>A0A8J2HDF9_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Gustatory receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HICCMSTLAB_LOCUS7453</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Cell membrane</location>
            <topology evidence="1 8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the insect chemoreceptor superfamily. Gustatory receptor (GR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5094926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HDF9"/>
    <dbReference type="OrthoDB" id="6366728at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030425">
        <property type="term" value="C:dendrite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043025">
        <property type="term" value="C:neuronal cell body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007635">
        <property type="term" value="P:chemosensory behavior"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008049">
        <property type="term" value="P:male courtship behavior"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050909">
        <property type="term" value="P:sensory perception of taste"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013604">
        <property type="entry name" value="7TM_chemorcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21143:SF132">
        <property type="entry name" value="GUSTATORY AND PHEROMONE RECEPTOR 33A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21143">
        <property type="entry name" value="INVERTEBRATE GUSTATORY RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08395">
        <property type="entry name" value="7tm_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 8 9" id="KW-0675">Receptor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="75"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="114"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="169"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="196"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="301"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="381"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAG5094926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="407" mass="47286" checksum="FDACD3705E01ABFD" modified="2022-05-25" version="1">MLFVGNKIRVTLKQTYQTGKLLIAIMSDTSENSRFYAYLLFAEHFTSKLIGLSSWKMDTVSIFRKNLFCTQLTTFSYKLSIIGSGYNILLVVFYVLCDIFIIKKNLNETNKAPVSIKFAFFSILCISVIPVIYVIRQKILISVKNQIKDVDNELMSCLDYKLVQNNINYWTFIINNVLIYCWIVFMLIFESLWVEIISMLIPMIFGSILIVQYAMIMNMIEKRFKSINVTLLKLKSSMHRTIFNDISSIKFAYFELCDMCDNTADFYGIPTLIVIILFSIRNISNYYEIILVFLSEIEMQNLFYCSGIFAVQTFFLFTTLTTSVTRLLKQNEETSRIINQLLDQFTINQAITEKLSKFSSDLWHMKVEFTLCDIVPLDCSLLTIISGTTVTYLIIAVQFYLNKTDQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HE13</accession>
    <name>A0A8J2HE13_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Similar to Synaptobrevin (Tetronarce californica)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HICCMSTLAB_LOCUS5934</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5092130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HE13"/>
    <dbReference type="OrthoDB" id="10042941at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001388">
        <property type="entry name" value="Synaptobrevin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016444">
        <property type="entry name" value="Synaptobrevin/VAMP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042855">
        <property type="entry name" value="V_SNARE_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45701">
        <property type="entry name" value="SYNAPTOBREVIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00957">
        <property type="entry name" value="Synaptobrevin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00219">
        <property type="entry name" value="SYNAPTOBREVN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00417">
        <property type="entry name" value="SYNAPTOBREVIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50892">
        <property type="entry name" value="V_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="V-SNARE coiled-coil homology" evidence="3">
        <location>
            <begin position="42"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="83"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="104"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG5092130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="140" mass="14565" checksum="A79FAEAAB6F01A83" modified="2022-05-25" version="1">MDFSITITASEGGLAPDAAAGANADGIVGGPRTPQQIASQKRLQQTQAQVDEVVDIMKTNVEKVLERDQKLSELDDRAAKFMPESQPAQQAGPVYQYGPPPGVPVAQPGAAPAPAGGAPQTAPAAYVGSLNDGLFRRRIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HFA6</accession>
    <name>A0A8J2HFA6_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Chromatin accessibility complex protein 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">DNA polymerase epsilon subunit p15</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">HICCMSTLAB_LOCUS8714</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Forms a complex with DNA polymerase epsilon subunit POLE3 and binds naked DNA, which is then incorporated into chromatin, aided by the nucleosome remodeling activity of ISWI/SNF2H and ACF1. Does not enhance nucleosome sliding activity of the ACF-5 ISWI chromatin remodeling complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Heterodimer with POLE3; binds to DNA. Component of the CHRAC ISWI chromatin remodeling complex at least composed of SMARCA5/SNF2H, BAZ1A/ACF1, CHRAC1 and POLE3; the complex preferentially binds DNA through the CHRAC1-POLE3 heterodimer and possesses ATP-dependent nucleosome-remodeling activity. Within the complex, the heterodimer with POLE3 interacts with SMARCA5/SNF2H; the interaction is direct and enhances nucleosome sliding activity by the SMARCA5/SNF2H and BAZ1A/ACF1 interaction. Within the complex, the heterodimer with POLE3 interacts with BAZ1A/ACF1; the interactions are direct.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5097451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HFA6"/>
    <dbReference type="OrthoDB" id="1291358at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008623">
        <property type="term" value="C:CHRAC"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22924">
        <property type="entry name" value="HFD_CHRAC1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000048">
        <property type="entry name" value="Chromatin accessibility complex subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003958">
        <property type="entry name" value="CBFA_NFYB_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050568">
        <property type="entry name" value="Transcr_DNA_Rep_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10252:SF54">
        <property type="entry name" value="CHROMATIN ACCESSIBILITY COMPLEX PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10252">
        <property type="entry name" value="HISTONE-LIKE TRANSCRIPTION FACTOR CCAAT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00808">
        <property type="entry name" value="CBFD_NFYB_HMF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0007">Acetylation</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Transcription factor CBF/NF-Y/archaeal histone" evidence="14">
        <location>
            <begin position="14"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="105"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="118"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="138"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="159"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00059032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00062516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00071805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00083235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CAG5097451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="180" mass="19879" checksum="EAAE45B0C44C5C6B" modified="2022-05-25" version="1">MAANQTPQKIRELRLPLARVRTIMKSSPDVESIGQDGLFLVTKATEMFIHYLATEAYTKANQKNALDYKHLADVAQTNETLEFLKEIMPRKITVRQFKELMAAKEATAQSSSSGSSDSDSDSQSDSESGSDSDSKKDDDEDDDNEEDDDDDHSSEDNKSISNGKNNSKMSGSSSESEHDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HFI6</accession>
    <name>A0A8J2HFI6_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS8466</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5096949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HFI6"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5096949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="116" mass="13337" checksum="F5124F2698D2BA08" modified="2022-05-25" version="1">MLINSGASLKSKLGSSPSKHTNDNFLPRLNISTEPRLRISIVPRLKISIVPRLKIINQDLSLEYWLDLGSRLANQDLLDRYWVDLGSKLINQDFGKETYTTGHKRHFYPIALSRNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HFJ0</accession>
    <name>A0A8J2HFJ0_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS7599</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5095217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HFJ0"/>
    <dbReference type="OrthoDB" id="10351255at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5095217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="170" mass="20134" checksum="A3A92189BEB9288C" modified="2022-05-25" version="1">MLVKFSIIFIQVEKSKRLFLKYLDHLRVFVDTNKVLKLALITERDNPIISKHFQKRETAVKELLTTFDPVEGEIDLLWAFNNVEECQKYIDYVIKLMTFPWKHIETTLCDPNCERIFANFRAIIRILKIETPDGTQSFFDELSPVKSDPEENPDPKKTIENFYIRTGQLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HFM4</accession>
    <name>A0A8J2HFM4_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similar to Thumpd3: THUMP domain-containing protein 3 (Mus musculus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS7218</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5093892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HFM4"/>
    <dbReference type="OrthoDB" id="47730at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043527">
        <property type="term" value="C:tRNA methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016423">
        <property type="term" value="F:tRNA (guanine) methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000241">
        <property type="entry name" value="RlmKL-like_Mtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14911">
        <property type="entry name" value="THUMP DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14911:SF13">
        <property type="entry name" value="TRNA (GUANINE(6)-N2)-METHYLTRANSFERASE THUMP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01170">
        <property type="entry name" value="UPF0020"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ribosomal RNA large subunit methyltransferase K/L-like methyltransferase" evidence="1">
        <location>
            <begin position="7"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5093892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="161" mass="17802" checksum="009F7ECD9F04AB28" modified="2022-05-25" version="1">MHRRNIAFFGPTTLRATVCYNLLRLAKPKPGEIIIDPMCGGGSIPIEATKEFPLNYIIGGDNHEKAMERSRMNFAMLPTAYKSDLIQWNLEHLPFKDSSALQAATDLFKVKKTLSISMGGLNAAAYVLKRTNLAYDSFLTRVTTLVTPKARSSSSSSDKSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HFX9</accession>
    <name>A0A8J2HFX9_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS8706</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5097435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HFX9"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5097435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="108" mass="12157" checksum="134F36B1C7FFA588" modified="2022-05-25" version="1">MSSTNGCENGVYIWIQGSIRGGACFVYGANGAARDYLRRHFRAKSDTADGIHMDAPATAVINALRVCNYQIHNSLSLEEFITCQHSRVVVLFLCYLFELKFYEQKISI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HFY4</accession>
    <name>A0A8J2HFY4_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">N-alpha-acetyltransferase 60</fullName>
            <ecNumber evidence="7">2.3.1.259</ecNumber>
            <ecNumber evidence="1">2.3.1.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HICCMSTLAB_LOCUS7900</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9 15">
            <text>L-lysyl-[protein] + acetyl-CoA = N(6)-acetyl-L-lysyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:45948"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:10731"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="EC" id="2.3.1.48"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>N-terminal L-methionyl-[transmembrane protein] + acetyl-CoA = N-terminal N(alpha)-acetyl-L-methionyl-[transmembrane protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50604"/>
            <dbReference type="Rhea" id="RHEA-COMP:12745"/>
            <dbReference type="Rhea" id="RHEA-COMP:12746"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:64731"/>
            <dbReference type="ChEBI" id="CHEBI:133414"/>
            <dbReference type="EC" id="2.3.1.259"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the acetyltransferase family. NAA60 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.259" evidence="7"/>
    <dbReference type="EC" id="2.3.1.48" evidence="1"/>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5095822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HFY4"/>
    <dbReference type="OrthoDB" id="47017at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004402">
        <property type="term" value="F:histone acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120518">
        <property type="term" value="F:protein N-terminal-methionine acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045141">
        <property type="entry name" value="NAA60-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14744">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14744:SF15">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="3" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="171"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="N-acetyltransferase" evidence="12">
        <location>
            <begin position="132"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00026111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00026144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAG5095822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="347" mass="39247" checksum="901D63F776B4C11C" modified="2022-05-25" version="1">MAGAVVIETNQNLQVFVSNKLMKNATLSNYKQQQQHQQQQQQQQQQYRECNGYNKMAISLERYNTSASPSGGLLSSPSSTGTAAIGVTSNKYNRESNKNEHNRPQNFVYNTNKSSTSSSLPVTVPLCLLGDVQLRFLCPEDLEEVRALCQDWFPIDYPYSWYEDITSSSRFYALAAVFGGVIIGLIVAEIKPFATLNKEDQGILCSSLGKESLVGYILSLGVRRAYRRNGIASLLLEQLLAHVTAPERSIVKAVFLHVLSSNAPAILFYQRCHFRLHSFLPYYYSIRGKCRDGFTYVLYVNGGHAPWGLWDWMRHLAGAMSSLGPCRVPHWIWQRLMWAATLLSYHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HGA2</accession>
    <name>A0A8J2HGA2_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS8111</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5096241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HGA2"/>
    <dbReference type="OrthoDB" id="7664046at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5096241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="233" mass="25780" checksum="CC9B218FDE8F84B9" modified="2022-05-25" version="1">MIPGESGIKGVTSFWEIVDDSLWNRTSKLNPESDRITATAVLDLPTFNDTCQVKVYGTVTYKMDEMELQAPVNFLSLTTTQAIDKSLTPRYAKDLHQSVVAMKAAAIEKVIAVPLHADGRGIKILSFIENKDFQEILNDVHVSKNPEVFRNCLIEVLSVESAVTMRISARSTAQLNILIHMLQAEFPDAIETGKQDKITDAVIALENEIKLKLGCDEPTNLLKAKVVTDLLVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HGW2</accession>
    <name>A0A8J2HGW2_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS9807</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5100734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HGW2"/>
    <dbReference type="OrthoDB" id="823504at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.640.10">
        <property type="entry name" value="Haem peroxidase domain superfamily, animal type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019791">
        <property type="entry name" value="Haem_peroxidase_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010255">
        <property type="entry name" value="Haem_peroxidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037120">
        <property type="entry name" value="Haem_peroxidase_sf_animal"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48113">
        <property type="entry name" value="Heme-dependent peroxidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50292">
        <property type="entry name" value="PEROXIDASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="177"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5100734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="227" mass="26590" checksum="4CF7083819DBB6A6" modified="2022-05-25" version="1" fragment="single">TYLLSNFILSTSNTLRLSRDVNSSLQNNNRKNWDFKVYDEYTAMFLKNANFEEAEDYGLQAMNFLFEIEEKKIFEKGLFLNSNHPAHYVAAFNYQTDEAKSFARVAYAALKGSRNLIEKFFNETLTNNLEWKSSALWTRQTAGFQERCPRKNKPSCPPASIKYRTADGRCNNLQHPWWGSAMSTMQSLLFLTFILVVSLKNTQHQQSIIFCLIDYVHVLNYVYFRYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HH79</accession>
    <name>A0A8J2HH79_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS5522</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5090185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HH79"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5090185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="143" mass="16940" checksum="6E7B81C5A7C4FE7E" modified="2022-05-25" version="1">MSEEASYSVEKFDHDNGQPIYLSAEIRDEELFKKFLERYRKVFQFEQNHPGEEISLSISGERVLFHVETRKVSYQAGCNMNEDEWRAAIKWIEKQERDGPWVVSPGDDDQKSVSQEDEETLLRDTIESGDEAEREREMREKEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HHN6</accession>
    <name>A0A8J2HHN6_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">RNA-binding protein 8A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HICCMSTLAB_LOCUS10319</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Heterodimer with MAGOH. Part of the mRNA splicing-dependent exon junction complex (EJC) complex; the core complex contains CASC3, EIF4A3, MAGOH and RBM8A.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Nucleus speckle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the RBM8A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5101246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HHN6"/>
    <dbReference type="OrthoDB" id="15688at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12324">
        <property type="entry name" value="RRM_RBM8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000157">
        <property type="entry name" value="RNA-binding protein 8A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008111">
        <property type="entry name" value="RNA-bd_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033744">
        <property type="entry name" value="RRM_RBM8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45894">
        <property type="entry name" value="RNA-BINDING PROTEIN 8A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01738">
        <property type="entry name" value="RNABINDINGM8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 10" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7 10" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="5 10" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="8 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 10" id="KW-0813">Transport</keyword>
    <feature type="domain" description="RRM" evidence="12">
        <location>
            <begin position="73"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="27"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="28"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAG5101246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="165" mass="18776" checksum="5F3D1D9C67B9DCA3" modified="2022-05-25" version="1">MADVLDIDNAEEFEVDDEGDQGIARLKEKAKKRKGRGHGAELASTRDEVGHYESMNVVEDDNEPGPQRSVEGWILFINSVHEEAQEDDIQDKFSEYGQIKNLHLNLDRRTGFLKGYALVEYETFKEAQAAKEALNGTEILGQAISVDWCFVKGPKKVKKRSHRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HHS4</accession>
    <name>A0A8J2HHS4_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6570 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS9724</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5100651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HHS4"/>
    <dbReference type="OrthoDB" id="7699899at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046700">
        <property type="entry name" value="DUF6570"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20209">
        <property type="entry name" value="DUF6570"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6570" evidence="2">
        <location>
            <begin position="164"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5100651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="218" mass="25545" checksum="C1A25A7A74BF91E6" modified="2022-05-25" version="1" fragment="single">MCRQNRRKKNENKIKIKKNPGKSSTERSREFRARKKQLLNNQNRCSNISVNVTGVINDRSQQQNSVPTGYNLVNNDYNPPVDVQPEIPYSRFHQDKFAHKEFNHKFLNNMFGHKCSVCDRLWFRLDLKSPRAEDEQLLSVIVENYNTVEDILLCNTCYQAIGRKVIPTMSTYNGFKYETTPDVLPPLDLISERLVSPRVPFMQIRRLRHVHGQYGIYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HI42</accession>
    <name>A0A8J2HI42_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS10605</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5101703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HI42"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5101703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="256" mass="28271" checksum="15E6DF1FB55F8B05" modified="2022-05-25" version="1">MTNFSLSIDSVESGAKFRLNPLSTERQTTECVYCQQNETSVTFASVTLSSSCWLDVVAASPLMRWRWRNLLLLRRSWWSTPSLSVVLSAVSSVTTSLRISAPSLVPLHHVAGWTHVASHHRTSHLTIRSTHGAHVTGHTHWRATLLRLMAPLSLVTPKVKNIFLIKIIKHPGYVVINNLNIITVLIVIKKKKNTYSPSVQLMGSILKNQSNISGIAKGDESKATTATGLAVLHNHTVNNFAITAEVSLQIFLSRLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HI97</accession>
    <name>A0A8J2HI97_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Similar to CAND1: Cullin-associated NEDD8-dissociated protein 1 (Pongo abelii)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HICCMSTLAB_LOCUS10711</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CAND family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5101830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HI97"/>
    <dbReference type="OrthoDB" id="6260732at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010265">
        <property type="term" value="P:SCF complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039852">
        <property type="entry name" value="CAND1/CAND2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013932">
        <property type="entry name" value="TATA-bd_TIP120"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12696">
        <property type="entry name" value="TIP120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08623">
        <property type="entry name" value="TIP120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25782">
        <property type="entry name" value="TPR_CAND1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="TATA-binding protein interacting (TIP20)" evidence="5">
        <location>
            <begin position="1042"/>
            <end position="1204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="313"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAG5101830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="1235" mass="138531" checksum="ABF553F782782C7C" modified="2022-05-25" version="1">MASVSYQIANLLEKMTSSDKDFRFMATNDLMTELQKDNIKLDDDSERKVVKMLLRLLEDKNGEVQNLAVKCLGPLVNKVKEYQVETIVDALCSNMISDKEQLRDISSIGLKTVISELPVGSNDLAENVCKRITGKLSSAIEKQEDVSVQLEALDIVADLLSRFGSLLVSFHPTILNALLPQLSSPRQAVRKRTIVALSHLLTSSNSFLYKKLLDHLLEGLTSQKVKNVIRTYIQCIASICRQAGHRFGEQIERVMPLIVQYSNEDDDELREYCLQAFESFVYRCPKEITPHINKIIEICLKYLTYDPNYNYDDDVNDESDGEGNVMETEEDGDEDGEDEYSDDDDMSWKVRRAAAKCLEAVVSSRRELLSELYKHVSPAIIARFKEREENVKSDIFHAYIALLRQTKPTSSVAMDPDSMEDEEYPISLLQQQVPLIVKAIHRQMKEKSIKTRQDCFSLLKELVVVLPGALTNHIPALIPGIQYSLSDKNSSSNMKIDALAFVHTLLVTHQPEAFHPFMVVLAPPIITAVSDPFYKITAEALLVLQQLVQVIRPHNKPVNPEFAVISTEIYRSTLSRLKTADIDQEVKERAIACMGQIIAHLSDTLNDQLPVCLPIFLDRLRNEITRLTTVKALTCIAASPLRVDLEPIMEEAIPILGSFLRKNQRALKLCSLTLLDTLVRSYSSSLHPELLDKVTTELTALLNESDLHIAQLTLTLLTTIAKLHPGALTRVSDSILPEILVLVKSPLLQGAALSAMLEFFQALVQAEIPGIGYQELLAMLIEPVNKSALHKQAYHSLAKCAAALTITWQKEAHGVVEQFIKNVQHPQNDAQHIFALLVIGEIGKHVDLSSISSLKHVILNSFSSLSEEVKSAASYTLGNIAVGNLPEYLPFILKEIEAQPKRQYLVLHSLKEIITCQSGSSSGVSHLQNFVPSIWQLLYRHCECTEEGTRNVVAECLGKLTLIDPTTLLPRLQESLKSTSPLMRTTTVTAVKFTISDQPQQIDAMLKQCMGSFLVALEDSDLNVRRVALVAFNSAAHNKPMLIRDLLDSVLPKLYAETKTKKELIREVEMGPFKHTVDDGLDLRKAAFECMYTLLDSCLERLDIFEFLQHVETGLRDHYDIKMLTYLMTARLAQLCPTAVLQRLDRLVEPLKNTCTMKVKANSVKQEYEKQDELKRSALRAVAALWTIPDADKNPALSDFMNVIKCTPELRMSFDAIQKDCSGNNVNEANTMDMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HIA1</accession>
    <name>A0A8J2HIA1_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 8">Pyruvate carboxylase</fullName>
            <ecNumber evidence="2 8">6.4.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">HICCMSTLAB_LOCUS8823</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>hydrogencarbonate + pyruvate + ATP = oxaloacetate + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20844"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.4.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>biotin</name>
            <dbReference type="ChEBI" id="CHEBI:57586"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.4.1.1" evidence="2 8"/>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5097679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HIA1"/>
    <dbReference type="OrthoDB" id="196847at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009374">
        <property type="term" value="F:biotin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004736">
        <property type="term" value="F:pyruvate carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06850">
        <property type="entry name" value="biotinyl_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07937">
        <property type="entry name" value="DRE_TIM_PC_TC_5S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.100:FF:000003">
        <property type="entry name" value="Acetyl-CoA carboxylase biotin carboxyl carrier protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.20:FF:000018">
        <property type="entry name" value="Biotin carboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.20:FF:000010">
        <property type="entry name" value="Propionyl-CoA carboxylase subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.600.10:FF:000001">
        <property type="entry name" value="Pyruvate carboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000033">
        <property type="entry name" value="Pyruvate carboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000012">
        <property type="entry name" value="Pyruvate carboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.600.10">
        <property type="entry name" value="pyruvate carboxylase f1077a mutant domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005481">
        <property type="entry name" value="BC-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011764">
        <property type="entry name" value="Biotin_carboxylation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005482">
        <property type="entry name" value="Biotin_COase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003379">
        <property type="entry name" value="Carboxylase_cons_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005479">
        <property type="entry name" value="CPAse_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055268">
        <property type="entry name" value="PCB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000891">
        <property type="entry name" value="PYR_CT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005930">
        <property type="entry name" value="Pyruv_COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006367">
        <property type="entry name" value="PRK08591.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006761">
        <property type="entry name" value="PRK09282.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009554">
        <property type="entry name" value="PRK12999.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01235">
        <property type="entry name" value="pyruv_carbox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43778">
        <property type="entry name" value="PYRUVATE CARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43778:SF2">
        <property type="entry name" value="PYRUVATE CARBOXYLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02785">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00289">
        <property type="entry name" value="Biotin_carb_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02786">
        <property type="entry name" value="CPSase_L_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00682">
        <property type="entry name" value="HMGL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02436">
        <property type="entry name" value="PYC_OADA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001594">
        <property type="entry name" value="Pyruv_carbox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00878">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89000">
        <property type="entry name" value="post-HMGL domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="PreATP-grasp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="Rudiment single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="Single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50979">
        <property type="entry name" value="BC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00867">
        <property type="entry name" value="CPSASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50991">
        <property type="entry name" value="PYR_CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 8 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 8" id="KW-0092">Biotin</keyword>
    <keyword evidence="3 8" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 8 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Biotin carboxylation" evidence="15">
        <location>
            <begin position="33"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-grasp" evidence="14">
        <location>
            <begin position="153"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="domain" description="Pyruvate carboxyltransferase" evidence="16">
        <location>
            <begin position="578"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="domain" description="Lipoyl-binding" evidence="13">
        <location>
            <begin position="1124"/>
            <end position="1193"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="325"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="149"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="233"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="268"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="587"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="659"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" description="via carbamate group" evidence="11">
        <location>
            <position position="756"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="786"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="788"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="923"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-carboxylysine" evidence="12">
        <location>
            <position position="756"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-biotinyllysine" evidence="12">
        <location>
            <position position="1159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR001594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR001594-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR001594-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR001594-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR001594-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CAG5097679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="1193" mass="131699" checksum="74BE72E0AB8280D2" modified="2022-05-25" version="1">MYSAHRACKALTRHRNSLRVLNVNFGTDVQYKPIRSVLVANRGEIAIRVFRACTELGIRSVAIYSEQDKMQMHRQKADEGYIVGRGLPPVQAYLNIPEIIKVAQENGVDAIHPGYGFLSERSDFAQAVVDAGIRFIGPSPRVVQQMGDKVAARQAAIEAGVPIVPGTDGPVCSSDEAMAFCQKHGLPVIFKAAYGGGGRGMRVVRKMEEVVENFERASSEAKAAFGDGAMFIEKFIERPRHIEVQLLGDKAGNVVHLYERDCSVQRRHQKVVEIAPAPRLDPKVRDRMTEHAVKLAKHVGYSNAGTVEFLADDKGNFFFIEVNARLQVEHTVTEEITGIDLVQSQIRIAEGMTLPELGMTQEKISPQGYAIQCRVTTEDPAKNFQPDTGRIEVFRSGEGMGIRLDSASAFAGAIISPYYDSLLVKVIAHAADLQSSCAKMNRALREFRVRGVKTNIPFLLNVLENQKFLNGNVDTYFIDENPQLFKFTPSQNRAQKLLNYLGTVLVNGPSTPLATQLKPAEIKPHIPDIPVDYSKLRATDVEDADLTEILEPPRGLRHILLEKGPEGFAKAVRDHKGLLLMDTTFRDAHQSLLATRVRSHDLLNISPYVAHKFSNLYALENWGGATFDVALRFLHECPWERLIDMRKAIPNIPFQMLLRGANAVGYTNYPDNVVFKFCDLSVQCGMDIFRVFDSLNYLPNLILGMEAAGKAGGVVEAAISYTGDVSDPNRTKYDLKYYTDLADELVRAGTHVLSIKDMAGLLKPKAASLLIDAIRQKQPDVPIHIHTHDTAGAGVASMLACAQAGADVVDVAVDSMSGMTSQPSMGAVVASLQDTPHDTNFDLRDVSEYSAYWEQTRTLYAPFECTTTMKSGNADVYLNEIPGGQYTNLQFQAYSLGLGEFFEDVKKAYREANILLGDIIKVTPSSKVVGDFAQFMVQNKLTAQDVLDKAEELSFPKSVVEFLQGAIGEPYGGFPEPLRSKVLKDMPRVQGRPGESLPPLDFGKLEKDLREVHPTITEKDVMSAALYPQVTNDYLKFKETFGPVDKLETRIFLTGPKVGEEFDVTIEKGKTLGIKTLAMCEDLTANGEREVFFEMNGQLRSVFIKDKEAVKELHIHPKADKSNKNQVGAPMPGTVIDIRVKVGDSVEKGAPLIVISAMKMEMVVQAPKAGKIKTLEVSVNSKLEGDDLLITME</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HIC7</accession>
    <name>A0A8J2HIC7_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">[histone H3]-lysine(27) N-trimethyltransferase</fullName>
            <ecNumber evidence="2">2.1.1.356</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">HICCMSTLAB_LOCUS8868</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-lysyl(27)-[histone H3] + 3 S-adenosyl-L-methionine = N(6),N(6),N(6)-trimethyl-L-lysyl(27)-[histone H3] + 3 S-adenosyl-L-homocysteine + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:60292"/>
            <dbReference type="Rhea" id="RHEA-COMP:15535"/>
            <dbReference type="Rhea" id="RHEA-COMP:15548"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61961"/>
            <dbReference type="EC" id="2.1.1.356"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.356" evidence="2"/>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5097769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6141102at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035098">
        <property type="term" value="C:ESC/E(Z) complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140951">
        <property type="term" value="F:histone H3K27 trimethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031507">
        <property type="term" value="P:heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19218">
        <property type="entry name" value="SET_EZH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.270.10:FF:000001">
        <property type="entry name" value="Putative histone-lysine N-methyltransferase EZH2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026489">
        <property type="entry name" value="CXC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045318">
        <property type="entry name" value="EZH1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048358">
        <property type="entry name" value="EZH1/2_MCSS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044439">
        <property type="entry name" value="EZH2_SET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041343">
        <property type="entry name" value="PRC2_HTH_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041355">
        <property type="entry name" value="Pre-SET_CXC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033467">
        <property type="entry name" value="Tesmin/TSO1-like_CXC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45747">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE E(Z)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45747:SF4">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE E(Z)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21358">
        <property type="entry name" value="Ezh2_MCSS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18118">
        <property type="entry name" value="PRC2_HTH_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18264">
        <property type="entry name" value="preSET_CXC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01114">
        <property type="entry name" value="CXC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51633">
        <property type="entry name" value="CXC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0678">Repressor</keyword>
    <keyword evidence="6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CXC" evidence="14">
        <location>
            <begin position="520"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="domain" description="SET" evidence="13">
        <location>
            <begin position="628"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="domain" description="CXC" evidence="14">
        <location>
            <begin position="1147"/>
            <end position="1248"/>
        </location>
    </feature>
    <feature type="domain" description="SET" evidence="13">
        <location>
            <begin position="1255"/>
            <end position="1370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="179"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="346"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1384"/>
            <end position="1404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="179"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="387"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="407"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1389"/>
            <end position="1404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CAG5097769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="1404" mass="161236" checksum="CCBDDAFF8A181E27" modified="2022-05-25" version="1">MSKVKVTAEWKKRVRSEYMRLRQMKRYKRADEVKIAWNQNRKVMTDLLVTEQKRWADGKATWLAMQDVPAHVSCMKKAEVTSSESDNQTCPVKIINAVTPIPTMYTWAPIQQNFMVEDETVLHNIPYMGDEILDQDGTFIEELIKNYDGKVHGDRESGFMDDSIFIDLVKALITYEKEDKEREPTRKVRDKEDKDKKEDARGDKTDIKDIKPVGRSPTMQIFNAISSMFPDKGSPDELKEKYIELTERSDPNVLPPECTPNIDGINAKSVPREQVMHSFHTLFCRRCFKYDCFLHPSREASPQGLQVCHPGPNLQKRKGPDLKPFSEACGSECYMHLEGVKEKLAAQAADNKDDEGDDKRGPRKVRKQASVDSGNEASSEDSNDSNKYSQNGNCQVKISPTDFKQNVNHESEKTEKTEEEEDQAQPDHQSPFMLLGLDKRTKQESQFTWTGSEQSVFRALYKAFPGNPCALAQIMLTKTCKEVYEFAQKEAHDIPAVESLKDYTPPRKKKKKHRLWSMHCRKIQLKKDSGANHVHNFAPCDHPGRPCDNSCPCIQAQNFCEKFCQCSTECQNRFPGCRCKAQCNTKQCPCYLAVRECDPDLCQTCGADQFQVTQISCKNVSVQRGLHKHLLMAPSDVAGWGIFLKESAVKNEFISEYCGEIISQDEADRRGKVYDKYMCSFLFNLNNDFVVDATRKGNKIRFANHSINPNCYAKVMMVNGDHRIGIFAKRAIQPGEELFFDYRYGPTEQLKFVGIEREMEFLYVRYEYRKIIKSREPKHIDNVNILWKNNKNIAKIEYVNEDAEAQNCSIVEFYPVKAIPSSYFWTPIKENVRVDDEVVLNNLPYMGDEVFKDDDTFLVDLLEHYQGKVHGKSGALDDDLFLELVNSLIKYDNCSLDTPTKKCNAMVKVSRLPSPDIFNAISAVFVDKGTPEDFLKKYLHLTEAFDISAAEAPPNIDSVDCKSLSREEALSSYQKYFCRRCFKYNCLLHRTKDSLSQNKLIGPRLEIIKEPCGKNCYLYKDELISSENQYIENNSKEDLDNRSTDNERTEIIAEKDVKINKHTKFTLSKIDERREIWTGSEETLFRAVYPAFPGNPCAVAQIILTKTCQDVYKFALQEGHDIPPERIEKLSPPRVVKTKQRVWPIRRRKKLLMKNEDKSYLCGYEPCDHLDKKCDDLCLCVGTQNFCEKYCKCSRECENRYPGCNCKAHCNTKQCPCLITMRECDPDLCRTCGADQFDVSKMTCRNVGVQRGLHKHLLLAPSDVAGWGIFLKDSAVKNEFISEYCGEIISQDEADRRGKIYDKLKSSFLFNLNNDFVVDATHRGNEMRFANHSINPNCYAKIIMVNGDHKIAIYAKRAIQPGEELFLDYSYRTTEQLKFVGIERKDQKPNQQNNFKGSSPSLPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HIT6</accession>
    <name>A0A8J2HIT6_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF4371 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS11185</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5102790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HIT6"/>
    <dbReference type="OrthoDB" id="10023262at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37162:SF1">
        <property type="entry name" value="BED-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37162">
        <property type="entry name" value="HAT FAMILY DIMERISATION DOMAINCONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5102790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="398" mass="45092" checksum="D34A275019B8E02E" modified="2022-05-25" version="1">MTNAKHYREAWENQPIFKGWLTKNSSELITAGHGEARCKFCKASLRAHASDLKKHAGTGSHLAQAKLWNIKKQPSLISHINSSQQKELKIAELKMVLYIASHSSVKSVDHLGEVLKELGKGSQLEKLRLHRTKASKLMLNVVAPAMLEELIDDIGEQDYSIILDESTDVSTIKYMAYCVRYFMFTATAESLFKNFKEFLTKVGLNINKLVAIGTDGANNICGFKHSLFTLIRKEYPNVQLMKCSCHSLSLCASKASDELPASVEFLLRESRNWFSRSPLRQTTYKNMYEKLSSGNKPPKLVQLSDTRWLAWTNEVSVVLKQWDALKGFFVQLEASPTNKCIIARNLGQMYRDDSNLLYLIFLDTVLKEVTDLNIAFQKANADITKLYSELRRLLLSVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HJC6</accession>
    <name>A0A8J2HJC6_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Olfactory receptor 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HICCMSTLAB_LOCUS9995</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5100922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HJC6"/>
    <dbReference type="OrthoDB" id="6614360at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005549">
        <property type="term" value="F:odorant binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004984">
        <property type="term" value="F:olfactory receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004117">
        <property type="entry name" value="7tm6_olfct_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21137">
        <property type="entry name" value="ODORANT RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21137:SF35">
        <property type="entry name" value="ODORANT RECEPTOR 19A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02949">
        <property type="entry name" value="7tm_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0552">Olfaction</keyword>
    <keyword evidence="8 11" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="9" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="51"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="85"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="142"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="203"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="318"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAG5100922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="408" mass="47114" checksum="0D62913737C77BA8" modified="2022-05-25" version="1" fragment="single">MALNQGETILSNKSENCHKHKAVKYTYFFLNLLGIGPLTTESLTITKIVSFIWSVTIVTIGVWEISFRFIYVYFDVTDVDDQMDLLAPVVFVTVTTLKYLSIIYRHDTIKKFTKHIIDDWSMIGSQEEEDIMEKNLDMSNNITFVFAVMMYISCVLYNCFMPHVIPLLFNSDDRNASERIVIFPGYNSVFDVDSFPIYQITYVFHQLTALSTYTILITSCNLIVVLVTHACSQLQIITNQIDSLLNNFSKKEKFSYTKLSFTISRHVRVLEFSNNLLKKMIFELCLIEVGASSILLCIDEFCVLRMLEKKEFANMTSYIMIFFSLSLNVLIVCYFSELLEAQFMNVGEKLNSVEWYKTPVNTRQYFNLIIIMSQQPQKISAGGIVDLSFVTYLQILKTGFAYLQLLRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HJS5</accession>
    <name>A0A8J2HJS5_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Similar to pmepa1: Protein TMEPAI (Xenopus laevis)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HICCMSTLAB_LOCUS8797</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Early endosome membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Endosome membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PMEPA1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5097627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HJS5"/>
    <dbReference type="OrthoDB" id="10038550at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031901">
        <property type="term" value="C:early endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070412">
        <property type="term" value="F:R-SMAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009968">
        <property type="term" value="P:negative regulation of signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043445">
        <property type="entry name" value="TMEPAI/LRAD4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16514">
        <property type="entry name" value="LOW DENSITY LIPOPROTEIN RECEPTOR CLASS A DOMAIN-CONTAINING 4A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16514:SF3">
        <property type="entry name" value="LOW-DENSITY LIPOPROTEIN RECEPTOR CLASS A DOMAIN-CONTAINING PROTEIN 4-LIKE ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0967">Endosome</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0734">Signal transduction inhibitor</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="139"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="192"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAG5097627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="226" mass="24462" checksum="BD85C258CDEB8D96" modified="2022-05-25" version="1">MKLRRRCIQTLGVSVKQLRRKLVELGARILHVHQTSKSSDMALMMLSVSAGMDVGCGGHGGLESATAVGGGADGMQEAMVAAARDRAVRTVSVRQDLALDLPPRLQLPDGEERPYGAHAGLHLRDPEQESEIYQKCVRPPPNRTIFDSESPPPYSRSQSTILDTPDRIIRCHSAGSSLLRVFRKFPSNVGGSTPVVVVPPSRRPSLSSYSESSSNLNNLSSLTVDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HJU9</accession>
    <name>A0A8J2HJU9_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS11832</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5104098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HJU9"/>
    <dbReference type="OrthoDB" id="6328726at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5104098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="184" mass="21548" checksum="F483705E38712181" modified="2022-05-25" version="1">MILFLVLSHEYALGIYLTNLTKLLEQRLLGATNHQDHLPAIVFRDLSYLPEIYNNQDDNNNYLSINNQLLRNDRNLLPEYRNLCEIKTKRVQLDDEEFEYQPPHYHEVYCKSYSLLEDTELGVAKKSKQMCAHPGFQCVQRSRVLSMVRRRWASGCWEPFTKEIASGCECMWPVSTLGDISAHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HKQ9</accession>
    <name>A0A8J2HKQ9_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Spatzle.1_TollPathway_Cc</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HICCMSTLAB_LOCUS7658</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5095336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HKQ9"/>
    <dbReference type="OrthoDB" id="8197497at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008083">
        <property type="term" value="F:growth factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005121">
        <property type="term" value="F:Toll binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0021556">
        <property type="term" value="P:central nervous system formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045087">
        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.90.10">
        <property type="entry name" value="Cystine-knot cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029034">
        <property type="entry name" value="Cystine-knot_cytokine"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032104">
        <property type="entry name" value="Spaetzle"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052444">
        <property type="entry name" value="Spz/Toll_ligand-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23199">
        <property type="entry name" value="NEUROTROPHIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23199:SF12">
        <property type="entry name" value="NEUROTROPHIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16077">
        <property type="entry name" value="Spaetzle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57501">
        <property type="entry name" value="Cystine-knot cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035184083" evidence="5">
        <location>
            <begin position="22"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="domain" description="Spaetzle" evidence="6">
        <location>
            <begin position="249"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="51"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="352"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="51"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="127"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="149"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="378"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="448"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="469"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF16077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAG5095336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="562" mass="63926" checksum="2691BBF93B543296" modified="2022-05-25" version="1">MRFEWNKALVTAVLLFSLAQADKNETLAKKPEKSETKISASLIVDNKTISSTEKSIETSKNSSEQVISRENARELSVEPDPDAEPISSEDSIDHEELPEALPEALELRNSRVGTRRRPFYRPPMRRPPNSNRRNVFPEPLRGSKRPVRKPADSNKREPTTSDCTFFGKTVCLKTLNYPQEAILRSIRGNRDMVDHLLKDYNIQREDRNDDVEADVFPLETRYERYESNEIRRRSDYPLAIDNNVEEGFTCPSQVMYARPQLARAASGVWKYIINTGDHTQTLRLEKCSKPKSSCSFISDNYRSSCIQVYNYHRLLTWDNDIGLHIDIFKIPSCCSCHVHGYAELYPPLQKDPSLPGEENFPGAEFSTDHSKGFERPSSYLSKLPSTYDSSYGGSKPLDASSSNHPSFILPRPRPKKPSSSSASRPFDKLPQQHAPNTRAPGYKGPMKVSKRPSRPNRPFRRESTDLEESSSNTNTNTNPNLNKWFEQAFDQGTDSHTRPNGEFEDDYEEPGRRVNYNYHPILEFFEPKASMLKATDPTSTQKSSIELTANGGSNSWKPMIAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HKY2</accession>
    <name>A0A8J2HKY2_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Similar to gpr180: Integral membrane protein GPR180 (Xenopus laevis)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HICCMSTLAB_LOCUS10431</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5101358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HKY2"/>
    <dbReference type="OrthoDB" id="45670at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007186">
        <property type="term" value="P:G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019236">
        <property type="term" value="P:response to pheromone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047831">
        <property type="entry name" value="GPR180/TMEM145"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019336">
        <property type="entry name" value="GPR180/TMEM145_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23252">
        <property type="entry name" value="INTIMAL THICKNESS RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23252:SF43">
        <property type="entry name" value="INTIMAL THICKNESS RELATED RECEPTOR IRP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10192">
        <property type="entry name" value="GPR180-TMEM145_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035301227" evidence="2">
        <location>
            <begin position="27"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="225"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="254"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="295"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="324"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="362"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="392"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="domain" description="GPR180/TMEM145 transmembrane" evidence="3">
        <location>
            <begin position="230"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG5101358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="492" mass="57749" checksum="C92275B3E9A9C8A0" modified="2022-05-25" version="1">MMLRSVILILWIGVLELLILIDQCESTHVTGTFNTNEFFRFLIKFGFQQTDRHRQRESYGYIFGNVTSQSNLSSSKLITFAVLDRNHFLEYYGNRTLEDKNTACSRMFNTLNQSSYDSQCNVNGEDFLRRIPCPKGQLCPDEDLPSNVIKNNQFTYVIQDLGQPRFWYISIVSCYRNIKTCKWEWFNESINIDYDVWLVNGNPNNSGFNSLTYQFSYDRQNTIELYLLFFLSYIILVPLQLYAVRLQRHPVTRLFTVSLLLEFIAICLILIHVLKFAFDGIGYEKLEVAGDIFDILSRATFMLLLLLLAKGWAVTRIELTWKPLVFLIWFCYGVVHILLYVWNMTEVDIIEDIDEYQTWPGWFILLFRSAIMIWFLLELRNTMTYEHNTQKLNFLLHFGASALVWFIYLPIVALIALQISTLWRFKFLLGITYSADCYAYCVMTHLLWPTRSEQYFLLAQGADNGDELDEFNEAPHVLNNYVEPSDLTKIIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HL73</accession>
    <name>A0A8J2HL73_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to Tmem94: Transmembrane protein 94 (Mus musculus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS10458</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5101385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5568754at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039720">
        <property type="entry name" value="TMEM94"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13219">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 94"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13219:SF6">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 94"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="51"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="86"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="272"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="304"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1092"/>
            <end position="1114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1123"/>
            <end position="1143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1163"/>
            <end position="1180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1192"/>
            <end position="1212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1232"/>
            <end position="1252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="438"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="458"/>
            <end position="489"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5101385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="1281" mass="146921" checksum="75FA856C042C05BB" modified="2022-05-25" version="1">MSNKIGLSTTEALEILHHEIERVLIEYKVDYHKNKKFHCWLKDSLHHKSQYTTLCWTSAVALFINAIILIIAYLNINQQSDQVSLLPYEALIICCFVILNFVLVISDNILRHNEIPHRVNILLKKINAARLLCKWKPENYPHLCTPLSPCVTLQWTYRDNVIVNLPWALLVTGDIIIIKPGQQVPGYCIPYNDPDGSPLYAKEIYSPNVNHNTNEIFTSPQARIPLKNKIYILKETPYLVNLRMALDQALDRPVTYHNRKRHLLMICCIEQLTYPILLITVLIVNLLRYLYFYKYAGTGHWTELFLLQPIAVTLPLLPIIFPIFWIVLNCFGMARFKALFQLYQSSSKISFVDPYDDTDIAGPNNPEVVYNWSELAEYFFSIIIGKEFMMSRSASILHVLGSVTALCCIDKKGILSWANPTAEKVFFLRNANALSRTSSSISLEKPSESPRTTTEPLYKNEQEQHHQQHEQKQQLKQEQEQDKEEEQKQKQKQQQQQQQNHRTTYVQHVAEVLDLTHDHALPFRLQFDDPSWRHHLNSLKPLGLAILLNTCNMETQEHYAQFCCHQPEMVRRDIKFARSLSIATKLKFPFPHMVAVVMKERTGGSLQLLTQGTADIILDSCIEFWDGHDLCPLSASDRKKIQDFYQRTSLTSYCTAFAYRPLIHTVNNKLSNIYLELPSDSKHLYAPHKSPTPVPWDFRNVIDPRVKGLLGQFHSTDSLLCTENKNEEINDVDSCFEMQCNQIFIGMVTMQYQAQADMVQLIEQLERACIRFVHFSKENELRSRVFSEKMGLESGWNCHISLLSERARSESPVGCWVSQAAAMSSPTSSDKFNQYNTDTCMMNEEASELLNRVCPRSNLDVSRTMSMSAPSAINMDYATVKFEQDTTEWHQDSVMQTKSAMSHREHDTIKSEDSVLVQSVELGSGQEAWRSLSCLTDSTEQSAPVNFDLSNRAKLPRGIDKIRPHIEMVDNVPLLVSLFTDCNTIVTREMLNIMQDYGEVVCVLGSSANADNMPIFMQADAGVAVEPLYPQVCQKIPVMVNTNDEQGPSPIDLSRALNSIACSLCVKREDPIALFHLVMEARDYMRCLWNCVQFWLCCIVTLSFTQALSVLLLLPPLFSISQVIWLICLIIPLLSISMMATPIDPTIMQRATGKNQCVVNSKVAFFVIWCYGIIISSGFVHREYLIFQRMPFNNLLWFCNIVIVLGLQVLFSGNTLYKLLKEEQRKNQKFPVQLPLFFLISIPLAFTINELVKWQEIKANVRHQKRARLEFGTKLGMNSPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HL88</accession>
    <name>A0A8J2HL88_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Similar to ab: Protein abrupt (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HICCMSTLAB_LOCUS11143</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5102706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HL88"/>
    <dbReference type="OrthoDB" id="10261408at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048813">
        <property type="term" value="P:dendrite morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030707">
        <property type="term" value="P:follicle cell of egg chamber development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061061">
        <property type="term" value="P:muscle structure development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007423">
        <property type="term" value="P:sensory organ development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd18315">
        <property type="entry name" value="BTB_POZ_BAB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.710.10:FF:000118">
        <property type="entry name" value="Abrupt, isoform B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051095">
        <property type="entry name" value="Dros_DevTransReg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23110">
        <property type="entry name" value="BTB DOMAIN TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23110:SF98">
        <property type="entry name" value="PRE-LOLA-G, ISOFORM C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13894">
        <property type="entry name" value="zf-C2H2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="BTB" evidence="8">
        <location>
            <begin position="39"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="335"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="561"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="611"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="640"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="128"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="203"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="390"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="463"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="699"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="853"/>
            <end position="907"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="210"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="397"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="418"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="433"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="463"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="493"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="857"/>
            <end position="879"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="880"/>
            <end position="901"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAG5102706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="923" mass="101544" checksum="A098B13C5AB024FA" modified="2022-05-25" version="1">MAASSSSSNSEQQYSLRWNDFHSSILSSFRHLRDEEDFVDVTLACDSNSFTAHKVVLSACSPYFRRLLKANPCQHPIVILRDVASSDMESLLRFMYHGEVHVGQEQLAAFLKTAQMLQVRGLADVKSSTAGAKIPSGSEARDHTESPVTSRNTWHDRGDPSDSGLSPPPEKRSKSYSPPVGNHLEQLKGAAADLQESLLGQALEGGPTIHTPNNDIKAQSTGEDSNSASDNDEEMSNNDSILNSVKAEPNDILNDSLEHHRGTFPAALLGLQGLMPGPSGIHAANQDPNYGSVMPMREDVAMMGVAVTDHETSSSQAVENLARLYSALRHDDSKPLCRYCGRSYSSPSNLRQHVKNVHSNWPPPETWPQCSVCGKRCKTKHYLINHQLQAHGIHQRPTVNNPQQQSGQRRKDGPPGPGGGGGGGRRVGGGVLTSTSAAASSTAYHHHDDRMLRVIKVEEIDVEEDYEDPVYPAEDSEDEKEEDEEDDEPKQMVTCSSISSTARQHQLTRVPNPQYQRPPLKRSQPQHHRRNLIQCPLCVRSYYDIADMRAHLDHHYPRDSPTCPVVSCAKTFSHPNSVRNHMRVKHAEQWDKIKTLRRGLDMMRVRATDPRPCPKCGKIYRSAHTLRTHLEDKHTVCPGYRCVLCGTVAKSRNSLHSHMSRQHRGISTKDLPVLPMPSPFDPELASRLLAKAGVKVSPAELRARASPTGPRRSDMRLELPRGAPSEAGSSVCGGDDPEDLTLPLSLRYGSPTPNNNTVITKINQQSKAATAIAAKSAIEGLMHAHSREPNTAPLHPAGLPLTPNHHQSILDTYLQYFAENSLNPFTINAAAVRAKMAMSGAIDAFGRGASDDYPMIGRDEGRPGVVMDDRNDHQDRDRTVDDEEAESSHAEDDEFSDNDEPEALKAEVSAMPSVVLLRIINSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HL97</accession>
    <name>A0A8J2HL97_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Similar to NPC1: NPC intracellular cholesterol transporter 1 (Homo sapiens)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HICCMSTLAB_LOCUS9966</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the patched family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5100893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HL97"/>
    <dbReference type="OrthoDB" id="6510177at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1640.10">
        <property type="entry name" value="Multidrug efflux transporter AcrB transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053958">
        <property type="entry name" value="HMGCR/SNAP/NPC1-like_SSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051697">
        <property type="entry name" value="Patched_domain-protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000731">
        <property type="entry name" value="SSD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10796:SF130">
        <property type="entry name" value="PATCHED DOMAIN-CONTAINING PROTEIN 3-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10796">
        <property type="entry name" value="PATCHED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12349">
        <property type="entry name" value="Sterol-sensing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82866">
        <property type="entry name" value="Multidrug efflux transporter AcrB transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50156">
        <property type="entry name" value="SSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="71"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="370"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="396"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="470"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="503"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="580"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="794"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="816"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="887"/>
            <end position="913"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="925"/>
            <end position="945"/>
        </location>
    </feature>
    <feature type="domain" description="SSD" evidence="3">
        <location>
            <begin position="366"/>
            <end position="528"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG5100893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="996" mass="112681" checksum="A5046FBA308A8720" modified="2022-05-25" version="1">MPISRKQKLIQTLAEHYKSYIYKAMDVTQESVVKRKSIRRSLRRIPQYIAATVEHFFYSLGVNIARQPITWIIGSSIVVLLCLGGLYRFRQEKNPLKLWIPPDSDFVKDTEWLMESFDKGQRVETVIMTADDVLQPHVLVEMNEIIKRIFAMATDSQPKLYWTDVCFKIPIISGYTNRRKRDIRNDDFFEEEPAAHSDKINFDPSVHAPTKIYCDILNNLPTGCLIFSILDLWEYNSHLILNQTKADIITKINSIKISPTLGHPMNFTELLGGVVIDDAGKIVSAKALKTHWMLHVDFKKINMNDAGNDVGTSDWATVDVLNWEKSFLNQLHSSSEHLKNENSSIKIWYEAGRSFGDISASTMFQDIKKIIIGIILMTLYVQIILSRFNWLKWRFYLTSAGLLCVGGAFIVAVGLCSLFGVPYGPVHSSLPFMLMGLGVDDIFVMMASWEEVLSHQSNQGKPIEERIGRMLSQAGAAISITSLTDVVAFIIGASTILPSLESFCIYAAVGVLITFLLQVTFFVAAFTLDVKRIESKRNGLIPCIVHKNHRPLQVDPTKTLSWRIFNWLYSKIVLTLSGKIVVLIITAAVTVVGAIGAYHLKQWFDPNWFLPKGSYLSNYISINDQQFPNRGNPADIYISDIDYLNEFPKLIAVTERLNNMTTIINSVESWPHDFVDFIKLYYNQDLINNKTVKIHDFNFYLSKFLFSRSGGRYQKNFRFNDTLTCGKNAPKITLSSISFTFQKFTGPDEWIPAMDNVKLAVKEMNFSKYATVWSKIFATWVTDKVIAHEVTRNIMLALICVMGTTALLIAEPQTCIWILLCVSLTLVDICGFMYYWGLSVDIVSCIGLELAVGLSVDYAAHVAHAFLNSKSLNDAEGDENNRTERALIAVRHIGAAVLYGAGSTLLAQSLLAFSEAYVFRTFFKIFFLVIFFGVWHGLLLLPVILSSIGPRSLQVDKTKITKNINRENKEKTDVLDSDIDPQDLNEQISLNTMESD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HN18</accession>
    <name>A0A8J2HN18_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Similar to stil: Protein stand still (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HICCMSTLAB_LOCUS10641</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5101740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HN18"/>
    <dbReference type="OrthoDB" id="7476629at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003656">
        <property type="entry name" value="Znf_BED"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02892">
        <property type="entry name" value="zf-BED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="BED-type" evidence="5">
        <location>
            <begin position="106"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="35"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="194"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="40"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAG5101740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="276" mass="31420" checksum="97CA509DACC761A9" modified="2022-05-25" version="1">MDNYSAPRYETKIESFDTCMIDVQGRDITAGVVSQSHQGTRCDNDHTDNNEATPIREQDHEQRHTIQIATIQNTMGQNMTLTPIRLPAILDGEFFSVVRVDDTNVTVRCQQCNKLLNGNLKSTGNFLSHIKRVHPTIIDKIKCKSNQRKPAIAYVDMSSEKSPEIIKTKRGYRKCSKQEEEPQVSSEEVFDPNPEMWIETTPNKKRKDESDADMNKYLNSSNTSTIEDEFDAIGKNVAAKLRGMRLDQRIVAEKLINDVLFEAQLCTLHRDSSLQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HNF6</accession>
    <name>A0A8J2HNF6_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Phosphotriesterase-related protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Parathion hydrolase-related protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HICCMSTLAB_LOCUS11006</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="5">Binds 2 divalent metal cations per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the metallo-dependent hydrolases superfamily. Phosphotriesterase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5102420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HNF6"/>
    <dbReference type="OrthoDB" id="9998343at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017947">
        <property type="entry name" value="AryldialkylPase_Zn-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001559">
        <property type="entry name" value="Phosphotriesterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10819">
        <property type="entry name" value="PHOSPHOTRIESTERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10819:SF3">
        <property type="entry name" value="PHOSPHOTRIESTERASE-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02126">
        <property type="entry name" value="PTE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01322">
        <property type="entry name" value="PHOSPHOTRIESTERASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51347">
        <property type="entry name" value="PHOSPHOTRIESTERASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="5">
        <location>
            <position position="25"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="27"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="168"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="168"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="200"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="229"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="297"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00020475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00029607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR601559-52"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAG5102420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="347" mass="39541" checksum="A483932C8A761653" modified="2022-05-25" version="1">MTPAGSVQTVLGSTELSKLGRTLTHEHLALDFDKFYVPPPRELSKHFRANFDIGNLGFVRQYPYSSRYNVTFNDVDTRKAIFEEIKLFKLHGGGTIVENTSHGIKRDIPLMVQVSQQIGVNIIVGTGHYVEACQKDLINEEQMYNLILKELTEGCEEYPSIKAGFIGEVGSSWPITEFEKKAIRATAKVQKQLNCPVSFHPGRNSQAPFEIMRIYLEAGGDSKKAVMSHLDRTLMKKDELLEFAKLGCYTQFDLFGTECSYYQLDEKTDMPSDAQRLDRIGWIKQDRGVEQVLMSHDIHTKHRLVQFGGHGYSHIYTNILPRMPARGFTAQEIDTITIDNPRRWLAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HNI8</accession>
    <name>A0A8J2HNI8_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transposase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS9671</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5100598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HNI8"/>
    <dbReference type="OrthoDB" id="8191915at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579">
        <property type="entry name" value="F5/8 TYPE C DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579:SF1">
        <property type="entry name" value="F5_8 TYPE C DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5100598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="760" mass="87140" checksum="880108FB54FFA8D7" modified="2022-05-25" version="1">MGKIKGKNSRGPYKQYNLLNNSKKIPVRTRYDWKKKHLARQLNQVSHDDKSLSSKLINSVQIEISDMCVNNNDSESLMNISDDNRVDDKIFEDCPDSAPRDTINDIQNESFPTNHDALNTSQIIDKTIPPTYKKEILKSQLINNLLVMAIKWRRNTTYAVAQDILNLYAIEDIYDGKAYKKVMTSDDMISINFNVDGAPIFESSNTSAYPVLCTLNELSPSDRKNHIMMSSIWFGNGKPKNMNAYLTPFVNEAKELLKEGLTYTFKGQTYAKKVIILIGICDSVARPLVQCTKQFNGEYGCGLCLHPGKSIAKGRGFARVYPVVNGEFFGEGLRSHEQTLIHAEAKTKEDKKGIKRKSALCDIPNYDIVKNLDVDWMHCVALGVSRQFANLWFDSTNSNKKFYFGDIIDQFDALILSLSPTSDFTRIPKGLKDRVHMKTHEWVVFLLAYSLPVMKMCFPIKFVKHWALLVDGISILTKKSIMKSELVYADQCLKEFIREVESLYGEKYLSFNVHLLAHLAESVENWGPLFTHSAFIYEDFNQLIENSVNSPNGVSIQICDSFRLKCTIDRLYNLCQNDLTPQQKKFFDGLRNKNSKPASTLVLRNCKVLGKSKIVTKLPQDQRRALQRLDIKLDSTYTIYKYRRCIINQEIITSKIYKREKKRTNYTVLLKNGQIFEIKCFVGLKNNNDVESYLIGNYYSSKKESFLKNRRLDQLISLNDKLHTISAISSKMVAQKVMIIKMNDDQLIAYVHLCNSELLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HPY7</accession>
    <name>A0A8J2HPY7_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS11988</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5104410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HPY7"/>
    <dbReference type="OrthoDB" id="6433782at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="220"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="354"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="408"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5104410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="445" mass="49015" checksum="B7B9C17EA990CB85" modified="2022-05-25" version="1">MNVPEFPAPPSLVPISSSSAATSVGLIREPANKNSKHLAGSWRANDLSGEKSFTRGISVSQLSSRPITGISRNLPSRRRAHRLARIGNSVHPRVVTKESSRVNRPRVTELKVSMTERREDDEDDADVVCASGTPVSLDSRTISEDLTIELKDQQTNEIVGMPFIKTIGIQTREREGPYWLRVFPKLKDIIEEEEEGENSRTCSKIWKHLRFLGRLSMCQFGLAWLLTFWAIAGAAAFYATEGPRETKQVAELKDMQRDLAVGLATELRQLKASEEEMEPLWSNKVRQYVAKHEKLLLAAVNSGYGEGGESGELWTFSGLLLAVRLQQYAVRKRYGADHDVEAIERLPVPQWVKIFPFILIAGYYLLGIIGFGAGRSRPLAASLLFPLDFTAAGGLASTSGFVRIAYGLYLEGAVTIAAVTVAALRVSASESLANIGRKYGLLVEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HQ44</accession>
    <name>A0A8J2HQ44_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Similar to akr1a1a: Aldo-keto reductase family 1 member A1-A (Danio rerio)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HICCMSTLAB_LOCUS12880</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aldo/keto reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5107711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HQ44"/>
    <dbReference type="OrthoDB" id="416253at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.100:FF:000006">
        <property type="entry name" value="Aldo-keto reductase family 1 member A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11732">
        <property type="entry name" value="ALDO/KETO REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00798">
        <property type="entry name" value="ALDOKETO_REDUCTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00062">
        <property type="entry name" value="ALDOKETO_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00063">
        <property type="entry name" value="ALDOKETO_REDUCTASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="7">
        <location>
            <begin position="18"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="4">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Tyr" evidence="6">
        <location>
            <position position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG5107711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="323" mass="36258" checksum="A940BCFA00F20281" modified="2022-05-25" version="1">MASKVTITLPNGQKMPALGFGTWQAKDEAVLTKALESALEAGYRHIDTAPVYENEHVIGKVLNKWIQSGKVKREELFIVTKLPPTGSRPGGVEKWIKKSLNDLQLNYLDLYLIHTPFTFEEIGDDLHPKDESGKIKIDKSTDHIAVWKEMENQVSAGRTKAIGLSNFNIKQIEKVISVAKEPIANLQIELHAYFQQNEMVNFCKKKGITVTAYSPLGTRGFVNLIGKNDKIPSIMDNSELIKIGKKYNKSSAQIALKFIIQKGIAAIPKSTNPKRIQENIDLFDFELDSNDIKIVNSLDQGPSARICDFDFFAGIREHPEYPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HQH1</accession>
    <name>A0A8J2HQH1_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Endonuclease/exonuclease/phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS11274</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5102967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HQH1"/>
    <dbReference type="OrthoDB" id="410104at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14529">
        <property type="entry name" value="Exo_endo_phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="1">
        <location>
            <begin position="88"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5102967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="558" mass="62674" checksum="5794E5BF3D884C46" modified="2022-05-25" version="1">MQNLFRHTFFPHPDIICLCETWATTDFTLPASLQDYTLHIAPVTKEKSSGHASGGIAIIAKKSLNITILDSSDSWLIAKATLGPTSIIIGNVYLRPQRNIASSLELLQLAIDEITQSHEHYACFLTCDFNAHVGPLGQISKEIILGTNLTEQRISNDQKIDTKGRLLTNFMLDNSFILLNGRTPSDSPGKFTYYGNGLSTIDFDWANIQSLPMINDMEVLHVENPSDHFPLLLTILNPHCAASAEHSTSTSKVVKTTYPWLPASRSEFKLQMLQSAKIVVDFNNTPIDDLSENLYNAVIESAQYACMVKKSPIPTNFKDPEKSAYINAKKNFKVLVKNKKRQSHKKTLESLANIKNAADFWATIKKHRKKHKSNATPIDIENWNSFYELIIPPKEPDDTLFYGKKLNLLTQYCQSNKLVVNVDKTRIIYCRLAGRLPRDLNFRFGDQKIEITENYEYLGLTDSASGFSHPLQSTPSTKLAQLSAQSSESSSQPKPTLYPTLLYASPIRALANLEFIEKIQCEFFKRVFGLPKTTAGALLRVELGRPRLAFIVKTISIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HQU7</accession>
    <name>A0A8J2HQU7_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Tyr recombinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS13900</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5109264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HQU7"/>
    <dbReference type="OrthoDB" id="7699712at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35617:SF3">
        <property type="entry name" value="CORE-BINDING (CB) DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35617">
        <property type="entry name" value="PHAGE_INTEGRASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="DNA breaking-rejoining enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5109264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="244" mass="28060" checksum="34A9366714A39879" modified="2022-05-25" version="1">MYQKNAYQRPNASTSPQPPSFEETINVSKSAGRLSLFKDIWALITSDLIVLTWISGYEIPFSQFARQNTTPTESKVCSRLRENRWWLICNQQEIPRYLFNITHILNFLTQEFNRDASYGSINSYKSALSLLLGAEVRQDARIKRFCKSIANIRPPKRKYNGTWDPDVVLKLLNQWPENGDLSLKRLSFKLVILLALTTGHRMQTFSLINVLDVQKQREAIVIKIPATIKTSGPRQAQPTPYITI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HR32</accession>
    <name>A0A8J2HR32_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Similar to Myrf: Myelin regulatory factor (Mus musculus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HICCMSTLAB_LOCUS11593</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MRF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5103605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HR32"/>
    <dbReference type="OrthoDB" id="27041at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016540">
        <property type="term" value="P:protein autoprocessing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd10144">
        <property type="entry name" value="Peptidase_S74_CIMCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1390:FF:000004">
        <property type="entry name" value="Myelin regulatory factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1390">
        <property type="entry name" value="NDT80 DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051577">
        <property type="entry name" value="MRF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025719">
        <property type="entry name" value="MYRF_C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026932">
        <property type="entry name" value="MYRF_ICA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024061">
        <property type="entry name" value="NDT80_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037141">
        <property type="entry name" value="NDT80_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008967">
        <property type="entry name" value="p53-like_TF_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030392">
        <property type="entry name" value="S74_ICA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13029">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13029:SF18">
        <property type="entry name" value="MYELIN REGULATORY FACTOR HOMOLOG 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13888">
        <property type="entry name" value="MRF_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13887">
        <property type="entry name" value="MYRF_ICA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05224">
        <property type="entry name" value="NDT80_PhoG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13884">
        <property type="entry name" value="Peptidase_S74"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49417">
        <property type="entry name" value="p53-like transcription factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51688">
        <property type="entry name" value="ICA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51517">
        <property type="entry name" value="NDT80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="663"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="domain" description="NDT80" evidence="10">
        <location>
            <begin position="224"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S74" evidence="11">
        <location>
            <begin position="544"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="NDT80" evidence="7">
        <location>
            <begin position="224"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="59"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="217"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="59"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="237"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAG5103605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="1090" mass="120907" checksum="E311E800A958C54F" modified="2022-05-25" version="1">MIKKHSVKCVSNIKFKLSRRGDFVGGIDNEALDFSQLEDFINSDSPQPATYFADTLAHNETNGTTTSHNGRVETTSQQPPTRLPSPISQNHPVQSACPAGATPVPPVTTYKDPQTYVHPHALPESPPDSGSEPPYSPPGHHETSQHVHSPHQKAALQEILLHHQGSAPAYTSTLLPTSPRALAASADPLLLAHPVLTPLLTPTTPALTAQQTLVASHVSLQQQPQQPQPPQHDHSPSGITTLYSSLQSAPKKRKHSQDGLIHVKQEPELGNVEHSCSSSSAVLDNDEVNGDNSYIDASYQCIRFHPFQQTTWHALCDHNLKELPTPHYRVDADKGFNFSNSDDAFVCQKKNHFQITCHAQLQGEAVFVRTSEGLKKISSFQLHFYGVKVESPTQTIRVEQSQSDRSKKPFHPVVVELGGERVTKVTVGRLHFSETTSNNMRKKGKPNPDQRYFHLVVGLHAHTSDQSSYQVVAHASERIIVRASNPGQFESEGTGVSTESGWQRGAAPDTVYHAGRVGINTDRPDEALVVHGNMKVTGHIVQPSDARAKQNVQEVDTREQLRNVQQLRVVRYRYAPEFALHSGLGIKAQEDTGVIAQEVQQILPEAVLPAGDIVLPNGQRIDNFLVVNKERIFMENVGAVKELCKVTDSLETRIDQLERINKLILILIMAFCLVAMATLYFLEYQKRSNLEWSAVAAGGMLAIGTAPTLPTTPSYDSRFNPLLHSTVSPFYTRQGLFTKTLDGHVTKDNVMSTSAPNTKQQYYSQEITSWYPFGHSGPQAKSDKNNELSNNWLRHGAGPVPSNVDENDQNADVDPPVLNRGPVPLGRPADCPLHFTELENACQIYCCTSDIHQLEEPRPEHPPEKKSMSIHLEQPLGVHEEKRKLNKGMQNGISPADSSTQTLVKDTHFKYMPKRSRREAGSGVWGEVASNAAGSIPPEPKPQLHIVAKSFNATLDQRYCSITSPSAPNNFSCNVPLSKHMPDTHLTLHFIGMPWYWQVVQQCQVTPSLTADETIACGWGYTHQKQQQHQYAENSNQPSDQAFVIDVAFYLRKTLKFRVPTVPPHEHVCKNNHGGDYLEFTMHFYRDCDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HRB2</accession>
    <name>A0A8J2HRB2_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">asparagine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HICCMSTLAB_LOCUS11817</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.22" evidence="2"/>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5104068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HRB2"/>
    <dbReference type="OrthoDB" id="360585at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004816">
        <property type="term" value="F:asparagine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006421">
        <property type="term" value="P:asparaginyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004522">
        <property type="entry name" value="Asn-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002312">
        <property type="entry name" value="Asp/Asn-tRNA-synth_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00457">
        <property type="entry name" value="asnS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22594:SF34">
        <property type="entry name" value="ASPARAGINE--TRNA LIGASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22594">
        <property type="entry name" value="ASPARTYL/LYSYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01042">
        <property type="entry name" value="TRNASYNTHASP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="8">
        <location>
            <begin position="160"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAG5104068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="447" mass="51143" checksum="550852C42D9E4B20" modified="2022-05-25" version="1">MFRRHFLRYLSTNSGPKNQKPLNVADKLEKKFDKVSGKRTKIQGWVKVIRKMKDKVFLEVNNGMTFEHVQVVAKKTDIPTNLSYDCSVFAAGEVAYAPNGRYEIRADEVRILGSCEVDGSYPLSFKKDYILDDLRQILHLRPRTAQFSSLLRLRSIASLAISKHMNERGFINIHTPILTSNDCEGAGEVFSVVPESRKMLDTMKKSKDQSVETLSKVYTFGPTFRAENSKSRMHLSEFYMIEAEEAFVTDIRMLTTESELLFKAITRALVEKGASDMHAIKAETPKWLDKDFRYMTYDDAINILDKHADKLSIPAKRGQALSKEHELFLVDYNDGIPTFVINWPKEIKPFYMKECSHDSSKVAAMDLLAPVVGEVFGGSLREDNYELLKQKIPPKANLEWYLDLRRYGNVPTGGFGMGYERFLQTVLGIPNIRDVIPFPRWPHNCSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HRP7</accession>
    <name>A0A8J2HRP7_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Similar to Arid4b: AT-rich interactive domain-containing protein 4B (Rattus norvegicus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HICCMSTLAB_LOCUS12074</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5106054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10068428at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
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    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0832">Ubl conjugation</keyword>
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        </source>
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    </evidence>
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    <sequence length="2211" mass="246954" checksum="8259E2183DBCBB69" modified="2022-05-25" version="1">MVVRKLERTPPLPPSPFPLSTSFSILGDDPPYLSVGTEVSAKYKGAFCEAKIRKVVRSVKCRVTYKQGLGTATVTDDQIKGTLRVGASVEARHVDKKEFVEATITKIQDCSQYTVVFDDGDITTLRRTALCLKSGRHFAESETLDQLPLTHPEHFGNPVIGGRRGRRSRQAQDDSSEDEGSPPRGSPSGSGLGGKEGAETEPEIGRVVCVELGDKKKKDNWFPGLVVAPTAQDTVRIRVRDDYLVRSFKDARYYTVPKKEATEFTKELGTKVENSVLKDAVTKALNFLEKNELPPHWDRDSLFGNSMSSGNSDTDGDLDSDSSDDEPREEKDHFVAQLYKFMDDRGTPINNCPMIGNEDIDLYRLFRAVEKLGGYNRVTNQNQWKSITRRLGISMQPTQATHNLVKQAYKKFLHSFEDFYRKLGCTMVNHPRGSTRKQRPGRSLIRDKDRNTPVPTAHQNIPKIEKEKAEGDDEQKEKKISVDEEKPVSSESSAPRDIVKEEEPKSVKKKEIVEEPVSGQESDINVEVESTESSSSEKSQKPPARFTPVSLSRVKSLTTTPSTTVITSAVTTATPTSTAATGKNKEESKKKSYEKKKQEGNSSSSSSGASVTGKKEIFKKDEETTKTRSKSKEDTKVKDSRETRTPSRESEKTRANSLKPRRLTDDELKKQQRGRKKREDTEKSRVDKDESSGAESSSAPCYKGPVQLGDRLKVYYGPTHESKVTYEAKVIGVESLDGSEEMNYLVHYTGWNTRYDEWIKAARIAQNFTQSQARVRRTKATLRPQTPSTSSSKSAKTLATTGLQGRRRAQSVAPTTSKTCSSTTSTSSSASSVNNKDNKESSQPARSTTPLSVNSFSSRTKSPATPAGTRPTRNTRNAEQLGIELRRRTRRMSGHTDLSVVTESEDSDAYETDTTEPERARTRSRGTEERRRREVRRRVEDRIKPDENSEIEDEKDVVNEPRRTRRLRRTPNKIQSKSEVDSSGAVADDDEDDVEDEENDENDDDDEEENQVADNFECAQQGHDEQPKGRDFDLNQIRSELKGFDKAVKMDLLRMEPENSGDEDSKPRVEDLQKEIKEEKKKIKDIKVEETVDVKPAVETLAVKADPSPSPTEDVYEFKEPEPFEFEVRNKRDSSGDKDKPKKRVFDEEPKSPKKKQKTSASSPKETKLTETEVDSKRKARKTPVKRPEETPEVIKPIVVPTPKEFEKVIEPPPTLIPSKATSVTLSPPTLVSAVIEEQTKNSSSIELFNDSTSNDDGTGDVDDPEDRLIIFETEVSETENENPPSNYQQEISTKILPSAEAPNKNEFNKKVEGNKDKEEKHVASSVPSTSGIPTITSSVDSLPLSDDRVGYEPKQWVIKPMNYKNPWGNEIKPPPPLPPPAVIDKKVVEVKTPVIERKIVDTKPPTIERKVIDAKPPTLPVITPSASSVPPNNTEQVIFEPKQWIMKYIFNQKQPSDVKPSVIEKKTSDSKSPSSDKLSDIKPSPSSSSIASLTTTTLGSPIVLAPISARLPATSTIEEKLSAAAMAFRQSKPRDSKRDDESGESKKNPKDSSKKSDSHGKRARVINDEQAKLKQELERKKEQEAAKIQEERSREVIRATLKQKEEELEQLKIHKEDLKKVADVKIDQRKIVDKREDLWKKKDKDIMDVEVSKEIPSEPKENEKQKRRKVLSQEFVDSTDSSDSEQKLVIDNSEVKEDRRESSDFEGKIKSEIELYPEGRSDHHQQVSSIVTQQEQSINFSKSVVSAKTEEEGENMNLLCEEEIPGSPAPVIDTTEQERPGDHQHHHHHHHHHHHHHHNLIKNESNEKKLVLLEMPFASAPALGPQSSTSQGSMSMTVTTACNVPVPVLIPMQPNVVTAPRQPLPLQHQQQHHHHHLHHQQPLQQQQQPQPQLQQLQSQQQLPKQDQLHQQQQPIIIPQPPPEQLPPPVVHQVIQPPRRESNEAAPVMDNTPPTTPDSSTISNISTSPRGDERTGGSSPLSDENIKLNRDTSEADNDSAGKAPSGYSEDDATLNADGNTAERGSSKAVKRSAEDPASPKKKKRSRKSSECGSNAGRKTSSRHSARQTRQSSAAGSDSDDTSEGSSSANNVNNNGNINTNSSHSSTGVVIESTNTASTTTTTATTNGITDLNSISSRSPKPIKYNFYVELDPQLDGSQRIALLQQKLTELKNTYNTVKLELAGIERRRKKLRRREREAMKAAKAEMQQACS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HRZ7</accession>
    <name>A0A8J2HRZ7_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">AP complex subunit sigma</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">HICCMSTLAB_LOCUS12709</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subunit">
        <text evidence="11">Adaptor protein complex 1 (AP-1) is a heterotetramer composed of two large adaptins (gamma-type subunit AP1G1 and beta-type subunit AP1B1), a medium adaptin (mu-type subunit AP1M1 or AP1M2) and a small adaptin (sigma-type subunit AP1S1 or AP1S2 or AP1S3).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Membrane</location>
            <location evidence="3">Clathrin-coated pit</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 12">Belongs to the adaptor complexes small subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5107358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HRZ7"/>
    <dbReference type="OrthoDB" id="371463at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030121">
        <property type="term" value="C:AP-1 adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005905">
        <property type="term" value="C:clathrin-coated pit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035615">
        <property type="term" value="F:clathrin adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd14831">
        <property type="entry name" value="AP1_sigma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.60:FF:000005">
        <property type="entry name" value="AP complex subunit sigma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044733">
        <property type="entry name" value="AP1_sigma"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016635">
        <property type="entry name" value="AP_complex_ssu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022775">
        <property type="entry name" value="AP_mu_sigma_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000804">
        <property type="entry name" value="Clathrin_sm-chain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11753">
        <property type="entry name" value="ADAPTOR COMPLEXES SMALL SUBUNIT FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01217">
        <property type="entry name" value="Clat_adaptor_s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015588">
        <property type="entry name" value="AP_complex_sigma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00989">
        <property type="entry name" value="CLAT_ADAPTOR_S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0168">Coated pit</keyword>
    <keyword evidence="10" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 12" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0813">Transport</keyword>
    <feature type="domain" description="AP complex mu/sigma subunit" evidence="13">
        <location>
            <begin position="1"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00065677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR015588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CAG5107358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="156" mass="18361" checksum="4ADA4D8C0E8BEA10" modified="2022-05-25" version="1">MQFMLLFSRQGKLRLQKWYVAHPDKLKKKITRELITTILARKPKMSSFLEWKDVKVVYKRYASLYFCCAIEQNDNELLTLEIIHRYVELLDKYFGSVCELDIIFNFEKAYFILDELLVGGEIQETSKKNVLKAIAAQDLLQEEETPQGFFEDHGLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HS33</accession>
    <name>A0A8J2HS33_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Similar to VPS50: Syndetin (Homo sapiens)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HICCMSTLAB_LOCUS13943</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5109307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HS33"/>
    <dbReference type="OrthoDB" id="10263345at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990745">
        <property type="term" value="C:EARP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032456">
        <property type="term" value="P:endocytic recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040047">
        <property type="entry name" value="VPS50"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019515">
        <property type="entry name" value="VPS54_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13258">
        <property type="entry name" value="SYNDETIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13258:SF0">
        <property type="entry name" value="SYNDETIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10475">
        <property type="entry name" value="Vps54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0653">Protein transport</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Vacuolar protein sorting-associated protein 54 N-terminal" evidence="4">
        <location>
            <begin position="60"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF10475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAG5109307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="414" mass="48424" checksum="B5CBA9A344F756AE" modified="2022-05-25" version="1">MENLKFKVFDFLHKQPQSQIPSMGLHPDLLNPLESNQPVNEELDFLKNLGNEVISDDKILESIESVYFQIDDSFDPCRHELNKILYRPNCKQIEKFNQQFNQQQYVVSKKVLQLILQKQSTCNQQFHEVLSIHNELHNLITTCKVGRLSLHSATIKFTIASLGILANYKRRQTIEKLMYSFNSIKTLRRTEDLLQDLLHDGNFPGAISLLLDCRSVAETYKHFYCIAALNKKLQDTLEQVEETLDSNLTKICEHFDEQIYSSIQEAYQLLGKTQMAIDQLHMHYTVTIHNTAFDIVYSYVGGNVKRQFKQICESISNENFIICLIDLSKTLWKIIHSYYQVLNWHGACGKYIVEQDEKSNKNVYNKQYVQQKLETGIVKIWHDIEIKISTYLMSTNVTCFKFEQFVRILSIINR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HT65</accession>
    <name>A0A8J2HT65_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Similar to FER: Tyrosine-protein kinase Fer (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HICCMSTLAB_LOCUS12904</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5107759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HT65"/>
    <dbReference type="OrthoDB" id="546826at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031160">
        <property type="entry name" value="F_BAR_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51741">
        <property type="entry name" value="F_BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="F-BAR" evidence="3">
        <location>
            <begin position="1"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="187"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG5107759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="347" mass="40235" checksum="B986277AAE426927" modified="2022-05-25" version="1" fragment="single">LTDDVARKKTEYQKNLEAYKLTRARFEEHYVNRGRGGRKLDDVREKYQKACRKLHLTHNEYVLLLGAVAECEHDLRSCYLPSLLRRQQTIHEEFIVAWKRILQNTVKYSDFTSEKFQEIHARVQTAVDSIKPLEEYKDFIGKHRKINDPKIRTRPASPLRFTFDENLVDDTSGKLLPNKLTVDNLTIDWLRSRLNELENSLKSTLQNRQATQSSNENTCDPRMTMLDYSREREELRLRCQEKKLQRQVEVIRGALNELGCEELPSGCDLSMEGSFAEPPPVIKRNTVADTGMFTLRRNQRFLTMIKTPFKTVPATNNNGNGIIRANSVGSSVKTIRPRLPVCLQLKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HUD1</accession>
    <name>A0A8J2HUD1_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Vacuolar protein sorting-associated protein 28 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HICCMSTLAB_LOCUS13817</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the ESCRT-I complex (endosomal sorting complex required for transport I), a regulator of vesicular trafficking process.</text>
    </comment>
    <comment type="function">
        <text evidence="5">Component of the ESCRT-I complex, a regulator of vesicular trafficking process.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the ESCRT-I complex (endosomal sorting complex required for transport I).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7 8">Belongs to the VPS28 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5109181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HUD1"/>
    <dbReference type="OrthoDB" id="2671at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000813">
        <property type="term" value="C:ESCRT I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044877">
        <property type="term" value="F:protein-containing complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043328">
        <property type="term" value="P:protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1130:FF:000001">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 28 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1440.200:FF:000001">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 28 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037202">
        <property type="entry name" value="ESCRT_assembly_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007143">
        <property type="entry name" value="Vps28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017899">
        <property type="entry name" value="VPS28_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037206">
        <property type="entry name" value="VPS28_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017898">
        <property type="entry name" value="VPS28_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038358">
        <property type="entry name" value="VPS28_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12937">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING 28, ISOFORM 2 VPS28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12937:SF0">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 28 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03997">
        <property type="entry name" value="VPS28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017535">
        <property type="entry name" value="VPS28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140111">
        <property type="entry name" value="Endosomal sorting complex assembly domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140427">
        <property type="entry name" value="VPS28 C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51310">
        <property type="entry name" value="VPS28_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51313">
        <property type="entry name" value="VPS28_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0967">Endosome</keyword>
    <keyword evidence="4 7 8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7 8" id="KW-0813">Transport</keyword>
    <feature type="domain" description="VPS28 N-terminal" evidence="10">
        <location>
            <begin position="3"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="VPS28 C-terminal" evidence="9">
        <location>
            <begin position="109"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00056039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00066174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR017535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAG5109181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="207" mass="23934" checksum="52DF19178CBC16FE" modified="2022-05-25" version="1">MSIAQDRPELNEEVKLYKNAREREKYDNQADLYAVVNTLQNLEKAYIRDCVTPKEYTAACSKLLVQYRAAFKQFPTIDVFAKTYRLDCPAALERIKEDRPITIKDDKGNTSKCIADIVSLFITLMDKLRLDIKAMDELHPELRDLVDTMNRLSILPSDFDGRQRVADWLQTLNNMSASDELSESQVRQLIFDLETSYNAFTKVLHNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HUK8</accession>
    <name>A0A8J2HUK8_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS13985</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5109349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HUK8"/>
    <dbReference type="OrthoDB" id="7617398at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="23"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="99"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="248"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="40"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5109349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="324" mass="38197" checksum="B7EA6604BFACA440" modified="2022-05-25" version="1">MPDGKEGNKAGNLNWFQTNFRLERTASTGDLEKPGAGGKRIREKEEESSLRKDEEDKEVLKRSKLQIRDQEKKDNLNQAEMDALMKKLGELDKRIVQECKKVSDEVGQLSEEARKEREEFMKKWEEEKLEMSGRIEKLEKRLEILEQDNRGNPFGEKVEIDSVLDKETERRLNKLEAGAERKEREARRRNVIIKGINMNEGTDWKREVDRVWAKLDVVGGRKSTRRIDRVDKEGKGMVLVEMEGFEKKREVMLAKNKLKREIIRLEDDLTFEERRIRRIIIEEAIKERATGKSVKVGYMKIWVNGKLRIWDEAEGRWKLQEGNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MEY5</accession>
    <name>A0A8J2MEY5_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">Origin recognition complex subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HICCMSTLAB_LOCUS4580</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the origin recognition complex (ORC).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the ORC2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5087693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MEY5"/>
    <dbReference type="OrthoDB" id="20198at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005664">
        <property type="term" value="C:nuclear origin of replication recognition complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007220">
        <property type="entry name" value="ORC2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056772">
        <property type="entry name" value="RecA-like_ORC2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056773">
        <property type="entry name" value="WHD_ORC2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14052">
        <property type="entry name" value="ORIGIN RECOGNITION COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14052:SF0">
        <property type="entry name" value="ORIGIN RECOGNITION COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04084">
        <property type="entry name" value="RecA-like_ORC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24882">
        <property type="entry name" value="WHD_ORC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0235">DNA replication</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Origin recognition complex subunit 2 RecA-like" evidence="8">
        <location>
            <begin position="254"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="domain" description="Origin recognition complex subunit 2 winged-helix" evidence="9">
        <location>
            <begin position="471"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="111"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="124"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="153"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU368084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF24882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAG5087693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="527" mass="60380" checksum="095A961ACD849A14" modified="2022-05-25" version="1">MSENNLRRSRRTRQQVNYLSEYVDLSPVKKELEKELAGIDEEVQKSTILFDDKDVSGNCIYGFQTPVKKNAMTEKAKQSQTPRTPASVSKNLMSVRVLAEKIDELSPAKVRSAVKKRQDHFDSESESVTEGSEYEPSDSDGEEECNDDDTIDSDASNQSDVENNAVNVTPKKNQRVAKKIQTPITPCRRGKSKNNIVYRDYHLKTDEYFETQSEKALTSDHTLGKLKNPKMNEEKLQELLKDKNYISEKHLEGIQELLDSYRSLFPMWYRILEEGYSLLLHGLGSKRNLINDFHQEILSEHPTLVINGFFPSLTIKDILEGIITELLELECPSNINDCFTIIESTMKKNPDDRLYLLVHNIDGTMLRSNKSQDMLSRLAAIANVRMVATVDHINAPLLWDNVKRARYNFYWWDTTTLLPYEAETSYESSLLVQRSGALALSSLRNVFASLTTNAKAIYTILVKYQIENAKNTFYHGMAFKDLYRSARERFLVSSDIALRAQLTEFLDHKLVKTKRNVDGADLHAIYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MHY4</accession>
    <name>A0A8J2MHY4_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to MPPED1: Metallophosphoesterase domain-containing protein 1 (Homo sapiens)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS3520</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0046 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5082303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MHY4"/>
    <dbReference type="OrthoDB" id="630188at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07379">
        <property type="entry name" value="MPP_239FB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024201">
        <property type="entry name" value="Calcineurin-like_Pesterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051693">
        <property type="entry name" value="UPF0046_metallophosphoest"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12905:SF0">
        <property type="entry name" value="CALCINEURIN-LIKE PHOSPHOESTERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12905">
        <property type="entry name" value="METALLOPHOSPHOESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF035808">
        <property type="entry name" value="Pdiesterase_Brain_239"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="2">
        <location>
            <begin position="42"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5082303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="301" mass="33410" checksum="B1D0C1D115446DCC" modified="2022-05-25" version="1">MDIDVHPLTDNPTEAWLELSQHQKVIKINAKPPAADAPTNKLRVVCMSDTHSLTPFIKFDIPPGDIFIHAGDFTKCGSLQEVIEFNNWIGNLPHKHKIVIAGNHELSFDSTFTHPFTPKNVGDRHKHTGTSILDDIPTLGMSKDTLAEAIQTKNVKDYLTNCVYLEDSEIVLYGIKIYGTPWQPEFCKWAFNVPRGTSCLSKWDLIPSDTDILITHTPPIGHGDLCCSGVRAGCVELLTSVQKRIQPKYHVFGHIHEGYGISSDGKIIYINASTCDLNYLPSNPPIVFDITLPPGVEKTSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MI07</accession>
    <name>A0A8J2MI07_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="17">CYP15A1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">HICCMSTLAB_LOCUS4188</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="2">May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 14">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Endoplasmic reticulum membrane</location>
            <topology evidence="4">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Microsome membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 15">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5084744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MI07"/>
    <dbReference type="OrthoDB" id="1055148at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016712">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008395">
        <property type="term" value="F:steroid hydroxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006082">
        <property type="term" value="P:organic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006805">
        <property type="term" value="P:xenobiotic metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000238">
        <property type="entry name" value="Cytochrome P450 2A6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050182">
        <property type="entry name" value="Cytochrome_P450_fam2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24300:SF376">
        <property type="entry name" value="CYTOCHROME P450 15A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24300">
        <property type="entry name" value="CYTOCHROME P450 508A4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 14 15" id="KW-0349">Heme</keyword>
    <keyword evidence="11 14 15" id="KW-0408">Iron</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 14 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0492">Microsome</keyword>
    <keyword evidence="12 15" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="10 15" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="16" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035178335" evidence="16">
        <location>
            <begin position="22"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="14">
        <location>
            <position position="440"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CAG5084744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="495" mass="57646" checksum="E85992193F316B14" modified="2022-05-25" version="1">MFLLFLSSLVIFSSICFWTHQKPHKFPPGPKWLPIVGCMFKFQELKNKCGYMYIAINELSQKYGSILGLKLGCQKFVIISGNDLLRKTLMKPEFQGRPDGFFFQVRAFGKRRGILFADGPLWYQSKRNTIKYISHIGFRHRLVDKYLTEEAETLVCYLKKKITNNKEKIAMNKIFDVAVLNSLWVLLAGYRFDYDDVRLHNILTTIHEAFESNDTLGGLISHFPFLRFIIPEISGYTSLMKTLHKLWKFIDDEIEIHLNKIQLHQPASNFIDAYLLERYDEKSRQFSYDRKELIVICLDLFLAGSKTTIDSLSGIFALLVHHPDWIKMLKDDLDMVVGNNMPKIDHLPMLPRIEAFLSEALRVLVLAPLALPHRTTENVWLEGFHIPKDTVVLFNFHSANFDESCWENAEEFYPQRFLNESGQFCRKIEFFPFGLGRRRCLGESLAKSSIFLFFTHILHNFNLEIPEGEKLPRLDGIDGFTISPRPYFLHLTPLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MJ47</accession>
    <name>A0A8J2MJ47_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS7407</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5094081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MJ47"/>
    <dbReference type="OrthoDB" id="371494at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36911">
        <property type="entry name" value="LIM ZINC-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="317"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="578"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="946"/>
            <end position="966"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1037"/>
            <end position="1057"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="344"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="585"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="955"/>
            <end position="966"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1040"/>
            <end position="1055"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5094081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="1194" mass="135201" checksum="AFB5BA7791BF6FDE" modified="2022-05-25" version="1">MPCFITSLPAEYNKESNNYNNINNNNTNKDGILIESQEHLIDKKILSVDNNWHNNNNNTYGINLDDDDNNNNNNNNPIRYQHQWLNYEGNQYQTEAAAAAVNFPLAVHKQGNLKTSTDYSTNSNYQDNVHVTDIITPSIPVDEALLLFENFGDKIIKTDDDLNYYENDTGTVESQNYYFSTELPIENNKDKTIRVSSENYKNALANFKSQLIKNSRVSLNNKTHVTTLTATSAANKNKLLPELSRLTFQNFNDSLTDIISENEQTKVIANQKVLTKFNTEEPIVVSETGIMIHKNYDYGTATLPCNIENENTEVVESQLLSSTTIPPPSEEEEKEKQLTKSSTDEGTTDYNTPVHSIHSVDSVNSPLFIRELSNRDQDTTSPVVLNSIQAGLALVNADKTHFIENKVEPLNQFKLNGYSDNYPFENINTSNKNSKNVKSIKSPAEKNVTLASINHDNDNDNDNDNYNYNDNGKLVEIQKSVELYNSAPIHEIHYPPALSINHPASPISSVSSVSLVSSASSASSASSASSASSDFVYITSHQDNNHQKNQMSYTNTDISDSNTDFSLKFLSIINQTTPSFSTSEQQQQQQQQQQQQQPVNLNNNIVFDIEKQKIIEINKNNNNFTNKNNIGGEIYETEDQMSSSSEFLEYKNKQAVEDNNGKNLLVDRESDNVSRYINSNNSSIKSHMDYNNNNNNNLNNFKQEGYSNLIEKDKIADATDNSEQTVYIYSPPVVSGGYGSIDISNYNINLPINSEIVEQSNYPVDKLVDGVLDITTGARYSQPYFVNKDNNNNNRVVEKYQYQYQKLKLKPKPKPKQKHVPVIQTYPVTAEKMSKNKVPSPHQPTKTITSTSNTGTYIQKFVSQPYPIHILEQLPYQVDKVIEMPIRIPSNHPLGEIPPRLSSSSSLLSSIKFDKLSNNNNPNYYHQIINPSIQSNGLLYPTRLQQTKSEKSENSEQGESFTNSSTLNLKGYTIGKQAVMPLVVAMRSPLSKRYSLLSQIGLVKHQQHQKNQQQQQQQQQQQQHIFNYYPSSNFKKQLYNNNNNNNNNNNNNNNNDLLNQLPISMHHPKSVVDQTSFQWHVIHPNEKQKITKIEYVGSVPSLTRHHVLNLHQNQVPHPAHQESLHYLGATDTSSSSSSSTLPAGSFFERLRLPEIHYYGKIGNFRQSKMEYGFKPPMVPSIQYDEETATKVDNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MK17</accession>
    <name>A0A8J2MK17_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Similar to POLD2: DNA polymerase delta subunit 2 (Bos taurus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HICCMSTLAB_LOCUS4991</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA polymerase delta/II small subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5088811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MK17"/>
    <dbReference type="OrthoDB" id="3763at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043625">
        <property type="term" value="C:delta DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006271">
        <property type="term" value="P:DNA strand elongation involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.430">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007185">
        <property type="entry name" value="DNA_pol_a/d/e_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040663">
        <property type="entry name" value="DNA_pol_D_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024826">
        <property type="entry name" value="DNA_pol_delta/II_ssu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10416">
        <property type="entry name" value="DNA POLYMERASE DELTA SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10416:SF0">
        <property type="entry name" value="DNA POLYMERASE DELTA SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18018">
        <property type="entry name" value="DNA_pol_D_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04042">
        <property type="entry name" value="DNA_pol_E_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0235">DNA replication</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA polymerase delta subunit OB-fold" evidence="4">
        <location>
            <begin position="37"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="DNA polymerase alpha/delta/epsilon subunit B" evidence="3">
        <location>
            <begin position="227"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF18018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAG5088811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="411" mass="46585" checksum="AD31B4672B2BD64D" modified="2022-05-25" version="1">MSEFSAMDYGEIKIERKSIEFEDFKKFIIGDKKFDKQYSNIYIARLRALKNILENKSKEKWGQYQVKTISQLGDDNDDESEAEKLVILIGIIYKHQELKPSILKELSDELQLIPQSSRSNYSSEKDQLFLEDEMLRIKLIGSDLNHKEMVTGLICGVLGYQSSGGTFNVKDYCVPGICPQASECSPLMFPSEDKILVLLLSGLDLSGNPDSLHYQLLSEWITATMETILATRRFDTLLSEIVSTSNVILMPGQFDPSNHSIPQQPFHPSILPLSFRYKSLYVATNPWIGKIGSRILAGSSGQPIEDIMKVANLNEYSPIDWLEKTLYWRHFAPTAPDTLAAYPYVETDPFIMDECPDIYFVGNTNEYATKCVIGDQGQTIRLICIPKFSKTHTAVVVDLLSLETWPITFQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MKA2</accession>
    <name>A0A8J2MKA2_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Similar to C9orf78: Telomere length and silencing protein 1 homolog (Homo sapiens)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HICCMSTLAB_LOCUS3401</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TLS1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5081879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MKA2"/>
    <dbReference type="OrthoDB" id="5627at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010756">
        <property type="entry name" value="Tls1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13486:SF2">
        <property type="entry name" value="SPLICING FACTOR C9ORF78"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13486">
        <property type="entry name" value="TELOMERE LENGTH AND SILENCING PROTEIN 1 TLS1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07052">
        <property type="entry name" value="Hep_59"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="17"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="69"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAG5081879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="173" mass="19755" checksum="014DDF086E29A479" modified="2022-05-25" version="1">MSTSEEVPVKIEFKKKKRNIPLRTRKVESDDSDDDNNGSVMSKIEETKIIQKLREKPKGVSYIEEELTKRKNTLSNNSDNPQDSDKNNYCSPEEAALQAVPEHLRLSSTHKSEEMLSNQMLSGIPEVDLGIEAKIKNIEATEEAKLKLLWEKHRKQEGPLSIVPSNINIDNKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MKF3</accession>
    <name>A0A8J2MKF3_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Similar to SMSr: Sphingomyelin synthase-related 1 (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HICCMSTLAB_LOCUS5307</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sphingomyelin synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5089621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MKF3"/>
    <dbReference type="OrthoDB" id="422827at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047493">
        <property type="term" value="F:ceramide cholinephosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033188">
        <property type="term" value="F:sphingomyelin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046513">
        <property type="term" value="P:ceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045221">
        <property type="entry name" value="Sphingomyelin_synth-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025749">
        <property type="entry name" value="Sphingomyelin_synth-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21290:SF25">
        <property type="entry name" value="SPHINGOMYELIN SYNTHASE-RELATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21290">
        <property type="entry name" value="SPHINGOMYELIN SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14360">
        <property type="entry name" value="PAP2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00536">
        <property type="entry name" value="SAM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00454">
        <property type="entry name" value="SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50105">
        <property type="entry name" value="SAM_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0746">Sphingolipid metabolism</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="143"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="184"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="219"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="293"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="317"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="342"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="domain" description="SAM" evidence="10">
        <location>
            <begin position="12"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAG5089621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="441" mass="50910" checksum="DF596B2F08D38A97" modified="2022-05-25" version="1">MAKTLPKDIVNWTNEDVIKWLEESGHGSCTFYFKAHDIDGKSLLTIREDDLKSQGMKIEKLGDVKRLYISIKKLQKENMAVLFELGQLEFTSSNFYSHNRQELQSFISNNESSVDPEFYSASVSDDGHASHLPPEIWKAFISLGYLFIVTWITAFVMVIVHDRVPDMKKYPPLPDIFLDNVPHIPWAFDICEVTGTLLFAIWLMVLIFHKYRFILLRRFFALSGTVFLLRCVTMLITSLSVPGAHLQCQPRPTPDDPWAKTAYGELYNKISMAYVIWRGAGMSIQGVRTCGDYMFSGHTVALTMLNFFITEYTPRQFYFLHTFTWMLNMFGIFFILAAHEHYSIDVFVAFYITSRLFLYYHTLANNQALMQRDSIRTRVWFPLFSFFESSVDGIVPNEYESPSKIICNLACTCRDIANALRQKISISNLQRTVNDSTKKGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MKX2</accession>
    <name>A0A8J2MKX2_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS3716</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5083043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MKX2"/>
    <dbReference type="OrthoDB" id="8046321at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5083043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="65" mass="7418" checksum="AB8C1998AC4DC5DA" modified="2022-05-25" version="1">MILGSNYNKKKIQTMEVFPSIVNGVIIPYVDSAKFLGVHINRNLSWKIHASLKVSKNIYATEIRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MM77</accession>
    <name>A0A8J2MM77_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS7152</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5093826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MM77"/>
    <dbReference type="OrthoDB" id="7671388at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5093826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="252" mass="28876" checksum="D432D1D79C4F2B4E" modified="2022-05-25" version="1">MEEIEKLKRSLLILNASVTGFPVAAVTLDDYKPINEKIKELRDSLNCLTARIKTLKIKLNLGSIESPTDDEAPRLVKNLNNNLTNCVINDNAVIACHQSYAVQQALFNKNVDPATHNRVKLLMANLYTLNDSILKYKKELSITLREQELSLRDEMYQLLMDYHEFLKVQEAIRSEKLAESNPEVAQKKARALKLITKINMMKRLITNFISVASHLVRENPDLKVILKRHRNLIDLDSIIDAKHQAHVEEPED</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MNB0</accession>
    <name>A0A8J2MNB0_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Catalase</fullName>
            <ecNumber evidence="11">1.11.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">HICCMSTLAB_LOCUS9590</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the degradation of hydrogen peroxide (H(2)O(2)) generated by peroxisomal oxidases to water and oxygen, thereby protecting cells from the toxic effects of hydrogen peroxide.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 11">
            <text>2 H2O2 = O2 + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:20309"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="EC" id="1.11.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the catalase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.6" evidence="11"/>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5100510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MNB0"/>
    <dbReference type="OrthoDB" id="6880011at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004096">
        <property type="term" value="F:catalase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042542">
        <property type="term" value="P:response to hydrogen peroxide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08156">
        <property type="entry name" value="catalase_clade_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.180.10:FF:000001">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.180.10">
        <property type="entry name" value="Catalase core domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018028">
        <property type="entry name" value="Catalase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040333">
        <property type="entry name" value="Catalase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024708">
        <property type="entry name" value="Catalase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024711">
        <property type="entry name" value="Catalase_clade1/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011614">
        <property type="entry name" value="Catalase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002226">
        <property type="entry name" value="Catalase_haem_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010582">
        <property type="entry name" value="Catalase_immune_responsive"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020835">
        <property type="entry name" value="Catalase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11465">
        <property type="entry name" value="CATALASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11465:SF9">
        <property type="entry name" value="CATALASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00199">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06628">
        <property type="entry name" value="Catalase-rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038928">
        <property type="entry name" value="Catalase_clade1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00067">
        <property type="entry name" value="CATALASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01060">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56634">
        <property type="entry name" value="Heme-dependent catalase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00437">
        <property type="entry name" value="CATALASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00438">
        <property type="entry name" value="CATALASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51402">
        <property type="entry name" value="CATALASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10 11" id="KW-0349">Heme</keyword>
    <keyword evidence="7 11" id="KW-0376">Hydrogen peroxide</keyword>
    <keyword evidence="6 10 11" id="KW-0408">Iron</keyword>
    <keyword evidence="4 10 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 11" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Catalase core" evidence="13">
        <location>
            <begin position="12"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="59"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="124"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="10">
        <location>
            <position position="334"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR038928-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR038928-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM01060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CAG5100510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="489" mass="55511" checksum="D7A24C790A68277F" modified="2022-05-25" version="1">MKSDLDKPPVLLTGNGAPIANKTASLTVGPRGPLLLQDFVYLDEQTHFDRERIPERVVHAKGAGAFGYFEVTHDITQYTRAKIFSKIGKKTPIAVRFSTVGGENPRGFAVKFYTEEGVWDLVGNNTPIFFVKDPLLFPSFIHTQKRNPVTHLKDMDMFWDFLSLRPESTHQVMILFSDRGIPDGYPHMNGYGSHTFKLVNNNNEFVYCKFHYKTDQGIKNLTAEEAAKISSQDPDYAIRSLYNTIAKKEFPSWTFYIQVMTEQQADKFQWNPFDLTKVWPHKEYPLIPVGKLVLDKNPSNYFADVEQLAFDPAHMVPGIEPSPDKMLQGRLFAYSDTHRHRLGPNHLQLPVNCPYKSISIMNYQRDGSMTIHDQDGAPNYYPNSFKGPEVCPAVKSPAFSAFGDIDRYEPVNEDNFGQVTTFWQKVLDADAKTRLVTNMANSLAKASNFIAERAIRNFSQVDVDFGQRLTDELRKKGKMINISGKGANL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MNH3</accession>
    <name>A0A8J2MNH3_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Similar to ZBED1: E3 SUMO-protein ligase ZBED1 (Homo sapiens)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HICCMSTLAB_LOCUS9772</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5100699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MNH3"/>
    <dbReference type="OrthoDB" id="1271298at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009791">
        <property type="term" value="P:post-embryonic development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008906">
        <property type="entry name" value="HATC_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003656">
        <property type="entry name" value="Znf_BED"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052035">
        <property type="entry name" value="ZnF_BED_domain_contain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481:SF10">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05699">
        <property type="entry name" value="Dimer_Tnp_hAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02892">
        <property type="entry name" value="zf-BED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00614">
        <property type="entry name" value="ZnF_BED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50808">
        <property type="entry name" value="ZF_BED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="12" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="BED-type" evidence="11">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="56"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="56"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAG5100699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="559" mass="64774" checksum="4FB97200500B0B55" modified="2022-05-25" version="1">MSSLWNHYIRISSGVAQCKYCKIQYNTKKTTSSLRYHIKNKHPEKCQPTTLIGEIDSDSQSEAENDPSTQENSNKRPRLSIPRKEYYSHRLYGLYDAVRNKLLSSLNQFPYVSITTDGWSSRANNSFVTITVHGIDDQWNLSSFTLDTLEMLESHNATNTYNHLAKTLNDWNLYDKVIAVVHDNARYMVATVRDNWEADDDIEISVRCFCHTLQCAVETALKECNLKDCLQRVSAIVGHFNKHSNKASTALENAQKKHHLPTHRLISHSPTRWNSAYDMVERLVEQRKAVECVLLDKEITTKKMMKKLLLNESDWTYLRDVIKIFKPFEVATRLMSSESQSTLSMVRPTVYSLLKKFLLQQDDDSENISLLKEILEKELTTRFLTNTNVTCCAIASYLNPRYKDLADEEESYRDKIKEKLKEMRERITVNEPDLSKNQRERDLDYLFDPVRGLSGNLQRMASLEGQSAIEKEMIKYEREPTIPKSDNPLLWWNSKRNKFPILANFARKFLCIPPSSTLSERVFSTAGNIISAKRSCLSPETANLLIFLYQNRDMIEKLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MP54</accession>
    <name>A0A8J2MP54_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to Npc1b: NPC intracellular cholesterol transporter 1 homolog 1b (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS9393</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5100118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MP54"/>
    <dbReference type="OrthoDB" id="6510177at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015485">
        <property type="term" value="F:cholesterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042632">
        <property type="term" value="P:cholesterol homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030299">
        <property type="term" value="P:intestinal cholesterol absorption"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015918">
        <property type="term" value="P:sterol transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032190">
        <property type="entry name" value="NPC1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45727">
        <property type="entry name" value="NPC INTRACELLULAR CHOLESTEROL TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45727:SF6">
        <property type="entry name" value="NPC INTRACELLULAR CHOLESTEROL TRANSPORTER 1 HOMOLOG 1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16414">
        <property type="entry name" value="NPC1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="170"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="Niemann-Pick C1 N-terminal" evidence="2">
        <location>
            <begin position="35"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5100118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="219" mass="24448" checksum="03F446142FCA013D" modified="2022-05-25" version="1">MVFCKIKSLERISLSDPALATKALDRVRIRLCSAQEIQTSSNLKSVLPTVVAHDLKEYINATFDSCRGVLFPATGGSAFDMACGDYGLSRCTPKRWYTFMGEMSKLFGGFQITYVYEPDQEKNLTEPLNSPTKSCSEAYENSTACGCVDCVCKNIIEWKKEDSVFTILELNGYGIVVGILIIIISTIFTLNQIFFKKFWASISVEVINSFIYSEQIILG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MQ06</accession>
    <name>A0A8J2MQ06_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Similar to MYO5A: Unconventional myosin-Va (Gallus gallus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">HICCMSTLAB_LOCUS11145</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5102710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6108017at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016459">
        <property type="term" value="C:myosin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000146">
        <property type="term" value="F:microfilament motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009653">
        <property type="term" value="P:anatomical structure morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048513">
        <property type="term" value="P:animal organ development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048731">
        <property type="term" value="P:system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009888">
        <property type="term" value="P:tissue development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd23767">
        <property type="entry name" value="IQCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15470">
        <property type="entry name" value="Myo5_CBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01380">
        <property type="entry name" value="MYSc_Myo5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.820:FF:000001">
        <property type="entry name" value="Myosin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.190">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.240.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.720">
        <property type="entry name" value="Myosin VI head, motor domain, U50 subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002710">
        <property type="entry name" value="Dilute_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000048">
        <property type="entry name" value="IQ_motif_EF-hand-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058662">
        <property type="entry name" value="Myo5a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001609">
        <property type="entry name" value="Myosin_head_motor_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036103">
        <property type="entry name" value="MYSc_Myo5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140:SF706">
        <property type="entry name" value="DILUTE CLASS UNCONVENTIONAL MYOSIN, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140">
        <property type="entry name" value="MYOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01843">
        <property type="entry name" value="DIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00612">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25966">
        <property type="entry name" value="Myo5a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00063">
        <property type="entry name" value="Myosin_head"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00193">
        <property type="entry name" value="MYOSINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM01132">
        <property type="entry name" value="DIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00015">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00242">
        <property type="entry name" value="MYSc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50084">
        <property type="entry name" value="Myosin S1 fragment, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51126">
        <property type="entry name" value="DILUTE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51456">
        <property type="entry name" value="MYOSIN_MOTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="3 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0112">Calmodulin-binding</keyword>
    <keyword evidence="5 10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7 9" id="KW-0505">Motor protein</keyword>
    <keyword evidence="6 9" id="KW-0518">Myosin</keyword>
    <keyword evidence="2 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myosin motor" evidence="13">
        <location>
            <begin position="80"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="domain" description="Dilute" evidence="12">
        <location>
            <begin position="1558"/>
            <end position="1831"/>
        </location>
    </feature>
    <feature type="region of interest" description="Actin-binding" evidence="9">
        <location>
            <begin position="663"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1118"/>
            <end position="1139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1168"/>
            <end position="1195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1662"/>
            <end position="1681"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="998"/>
            <end position="1057"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="1213"/>
            <end position="1297"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="1343"/>
            <end position="1429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1123"/>
            <end position="1138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1168"/>
            <end position="1177"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="173"/>
            <end position="180"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CAG5102710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="1847" mass="212799" checksum="BF07C5EACB5713D8" modified="2022-05-25" version="1">MGQNRPQRSRLQKYKQTNIQGAKVWIQHPEKIWEGAILLDDYKSTDTSIKLQIDDTREQRVVEVKTDKELPPLRNPDILIGENNLTSLSFLHEPAVLYNLQVRFQRRCIYTYCGIVLVAFNPYDELPIYGNDTIWAYRGQAMGDLEPHIFAVAEEAYTKLERELHDQSIIVSGESGAGKTVSAKYAMRYFATVGGSSTETQIEKKVLASSPLMEAFGNAKTTRNDNSSRFGKFIEIQFNKNYHITGASIRTYLLEKSRVVFQAHQERNYHIFYQLCAAATSPPQASPSDVSARLKNLQLDKGSSFHYLNQGNCFTIDNLDDSRTFQDTLSAMTRLGFESKQQEEVFKILAAILHLGNVEIVQDSRASEGGDSEACMIASGDRHLTILAQLMGIDPSGMRKWLCHRKIVSMRDVILKPMNVEQAIGARDALAKHIYAELFNFIVHGINESLRSKVKASLSFIGVLDIYGFETFEINSFEQFCINYANEKLQQQFNQHVFKLEQEEYLKEEIEWTFIDFYDNQPCIDLIETKLGILDLLDEECRMPRGSDDSWAEKLYSKCVKSKHFERPRFGTNAFLIHHFADLVEYSTIGFLDKNRDTVMEEQIDVLRSSDNKLLKQLFNDDPPKLSVPSGQSKIKISAQKPLANAAPKQNKKTVGSQFRDSLNMLMSTLNATTPHYVRCIKPNDSKESFEYDAQRAIQQLRACGVLETIRISAAGFPSQRTYADFFSRYRCLCPFKEILREDLKETCRRILKYYIKDEDKFKFGKTKVLFRAGQVAYLEKLRSEKQKDACRMIQKRVRGFIIRRRYQEIRKAVLGLQRHARGYLARVKAQRIRRERAAVKIQTSIRGWVARTRYLRVRRTIISLQRYARGLLARKKYAIMKDNAAATTIQRFARGYLVRAAVKQKINNIIIVQCCVRKYLARRIFRRLKAEAKSVEHVKTLNKGLEKKIISMQHRINEILKENQALRVVQTEVVDLKVKLEAMKAVELENKKLVGVLVEKDRELELMAETVKREQDEKMDLLLEREKLIKEKEDENKRLSEETERLKRELAVASEKLKIDQRGAEENLKHRLEQEKDLLLMDHDQDRGAYQRLLKDYQDLEEHVEVLERKLALHAPGEGHSRSLSNASSGSVGQAASTDVPEENIDFGYGSVRSTVSSTAYSRVETIDWHQRRSESPPDGEAQPSKPVENGNGGLVAAPVDIGLVLKLQQKLKDVESSYGRLVRTMEDLERDSGEDALRTQDTFKLEELEMENAQLKKDLGTLRKAVVDGDVNSAQKELTSQFDALQEELERRREECIQLHSVLADNTKRMKSLGSNYGRDVDIINEDGELALAFEAQKKINRQLEDELQTKEKGWREQRNEWRNEIDRLQEEMQKLQKLLSVNLSNTPKTQTEAFMQHEIVKITSEYLDLQEKYDKVAEECQKLKKRCRIFAKRLRDAGCEDSEPKQLPEPPKPRAFMITAPVPDTVDPAPNQSVITSQQSNGTVMPAIRKKERDYEGMFEFRKEDITSIIRNLVIELKPKVAVTLLPGLPAYILFMCIRHTDCINDDDKVTSLLTGYLNAVKRVIKKRDDFDSTVLWLSNTLRILHNLKQYSGDKPFQMENTARQNEQCLRNFDLSEYRSVLSNVGVWIFGHVMTILKERIQALTVPALLEHEAITGLNSNKSGRPRSSSVGEEPESTQQKLNKLLDELGLIHKTMQYHGVDKDVIVQIFKQLFYFMCASALNNLLLRNELCHWTKGMQIRYNLSHIEQWARDEQLVPAIESLQPIIQAAQLLQARKTDEDVNAVCEMCNKLTSNQIIKILHLYTPADEYETRVPVTFIQNVQEKLKQRQENNEQVFFYFIYYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MRZ0</accession>
    <name>A0A8J2MRZ0_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similar to Cerk: Ceramide kinase (Mus musculus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS8831</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5097695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MRZ0"/>
    <dbReference type="OrthoDB" id="530923at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001729">
        <property type="term" value="F:ceramide kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006672">
        <property type="term" value="P:ceramide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10330">
        <property type="entry name" value="Probable inorganic polyphosphate/atp-NAD kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017438">
        <property type="entry name" value="ATP-NAD_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045363">
        <property type="entry name" value="CERK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001206">
        <property type="entry name" value="Diacylglycerol_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050187">
        <property type="entry name" value="Lipid_Phosphate_FormReg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12358:SF111">
        <property type="entry name" value="CERAMIDE KINASE, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12358">
        <property type="entry name" value="SPHINGOSINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19280">
        <property type="entry name" value="CERK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00781">
        <property type="entry name" value="DAGK_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00046">
        <property type="entry name" value="DAGKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="NAD kinase/diacylglycerol kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50146">
        <property type="entry name" value="DAGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DAGKc" evidence="1">
        <location>
            <begin position="125"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5097695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="497" mass="55984" checksum="B8B5CF8554FB363D" modified="2022-05-25" version="1">MDNEQFLNSVLLNTFIIKKKRCRVYFHKGTLIWETERPPYIRWTLPLTDALAVNYGDDYIPETRIKEKDPDAIGASSPTSFILHYAARGPKNRWSHHNVVMSHTDPRQVASWVKTIRNYLLSIAHRPRRIIVFVNPFGGKKKGNKIWEKQVQPLMKIAGVETKTIITERAGHIHDCLLNSNLDDIEAVVCVGGDGTFAEVFNGLILRAAKDHQVDPNNPDVTLPTPKLPVGVIPSGSTDTVAYSLHGTTDIQTAVIHIIFGDTAGLDISSVHGDRTLQRLYASVLSYGYLGDVIRDSEKFRWMGPQRYDYSGFKKIIANRGYEGEIELLSDPCHPAASTRCMKNCTRCIRHMHNSIADKEIARWLTVRGKFFMVNGANVSCACSRSPQGFSPHCHIGDGCIDIILVRHTSLFNNIRMLLRLTSKNKTVYDLPFVEVYRAREFTFRASSTTESSNDTTVNTSSQLSVWNCDGEVLQHADSAHCKNIFVLKSFHYTNES</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MSF8</accession>
    <name>A0A8J2MSF8_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Similar to Znf710: Zinc finger protein 710 (Mus musculus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HICCMSTLAB_LOCUS12598</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5107124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MSF8"/>
    <dbReference type="OrthoDB" id="7697749at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050888">
        <property type="entry name" value="ZnF_C2H2-type_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24406">
        <property type="entry name" value="TRANSCRIPTIONAL REPRESSOR CTCFL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="181"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="274"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="347"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="477"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="542"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="76"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="206"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="308"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="378"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="579"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="682"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="997"/>
            <end position="1022"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="80"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="98"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="221"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="380"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="415"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="591"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="685"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="997"/>
            <end position="1015"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAG5107124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="1158" mass="132173" checksum="1B38B8F43624A2B8" modified="2022-05-25" version="1">MEVIPPSISDKVDTSIEPESNKISDVETNNVVTINTAEFQDPLELSLEIEATYGLKPCFVELERCDKIWETIQLIRDLQEDPNPETSDDETGSEMTDDYYNYDNDTVNNDDAEMINGDVENSNLTPINDDEPSSSHHDTESCSSTQNNPTAPYIKYQPVLGNGNTALPNFQFSVQRTRVLYPCVTCGKQYNHIRSLKEHEERIHNIIQPPVRKKSDHVTKNETNSSNNQENEVSNNNKSVESAPVKNIRSEDTAIVDTTEFIKSIMAYEPGIRITCCFCDRVYSDKYNLKKHVVSMHGGAPELIRSYKRKQPQQSLPEPEPAAEEAIHQEPPQKKRRVERSRNLNVYRCETCGKHFYSLKNKRVHNRKVHGIYIRPPVGKNINKQVGNNYNNNSKKSNEGSKVQTKLSLSSSSLTYESPTKNNVPENQNSENGILRTCPICNVKTTKLNIFKTHCKSHGITIKFDNIYPREQAKTELDCKVCGETFMTSNHVVEHYWNIHRRCLRYKCYICGALSHESENLVKHLLKVHKVYFLLRKPIYNFQCHVCMRNFSSKSVYRMHVTQGHGLDLKTKQVEEVLKSTGRTDDDASPLLPPPPPPPPPPPPLLSPRSASAKKRAIKRDLKRPAQIKRQVKVEKPRSPSTRNGLREKSKFNYNENISLLDTAVNFSNSSLDEIPIAQKRTRKSSILSNDKSNNSISDDVPMESKPKEPTYCILCSKNGFKNLRKHFLEYHKVRDPDPLMEQSLKMMPATSEPVIKAEKTVKKEVKIEKKEVASPVKKAVIRRRSNPEARKINARVKQQVSSIKEPCIPGPLRTFAAVRDEDGSLRFICKFCPLELKSYEKMRRDEYNHRREFSNLSVVEMKPSNPKYLNMDPDLILKQKIRRTNSSLPKSNLLMDDPESLLRRSSFPLEKFKESNNYLTQESIKQYHEPIEHRCSNCSRLFRNGDILASHKISCKVRVDHQQITNDTSDTRESSDRDSGIGISITIKKKNDSYEIVSRDNSDDSKSQDSESHPNDLLLTDTPSDILLNGIIPNQKNSEEVSTTISNNNALELNETREEIKIQKIDNDENMDVDADDQNTIPVPSPVIVKPQVTKRKMSAGCKVRQIPSLVLLSTHVLDRIHANESCTRKCYICNTDWPSAISRASHMTGIHKSGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MSW5</accession>
    <name>A0A8J2MSW5_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Doublesex</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS13098</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5108159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MSW5"/>
    <dbReference type="OrthoDB" id="10290845at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5108159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="76" mass="8127" checksum="4EDC9C2FE5A451EC" modified="2022-05-25" version="1">MLQDNSGIYYNDWYPGGNNIVTPTYLGHPPFMGGGVAPSPTSVHLGPLPHLLNAQVLANRLPSSPDSPPEEPTTLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MTN1</accession>
    <name>A0A8J2MTN1_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS12781</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5107513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MTN1"/>
    <dbReference type="OrthoDB" id="7695252at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5107513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="61" mass="7032" checksum="36929690A9065249" modified="2022-05-25" version="1">MPPTIPPDSAMCSLCPRPKKPQKKLVRFDSVVDTFSISDSSGPRRSKQFNKLFNKLKRFDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MWX5</accession>
    <name>A0A8J2MWX5_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS10917</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5102242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MWX5"/>
    <dbReference type="OrthoDB" id="8192055at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035263649" evidence="2">
        <location>
            <begin position="19"/>
            <end position="896"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="213"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="374"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="492"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="860"/>
            <end position="896"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="235"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="437"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="499"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="565"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="641"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="684"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="761"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="797"/>
            <end position="809"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5102242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="896" mass="98720" checksum="A0DA56948F80B05A" modified="2022-05-25" version="1">MTIMFHFRICCAIAAVLGNKNVNLENGSYDNHEKHPRVNDFAQKIQKTGPKVQEIGVVNQDLDPNHSYNDDNDNEQLNLSPKRQARVELENFSNTGVIQEDAKKKIDTFKNKNEKTDLNIEGVQVSSEYPTTMRPILTTERSYSQSSYDFVPVNLIPKDYKESWSPYSNRNFDYLSDVSLVPAGSNSRIQIKKGPNGKDYEYEYVYYYYDEEDESSKGSASNNKQESIRTPPPSRRGSSNNNRSKYSSVERTSTAEPVGNEIIPKNGNRGRNLAENEEISEERLPTNTRFPPRSRSNHNTGTTETTRSRGNRPRPNLDLVDSSSFRTHQEGPEFPQSLPKGPVRFLGVTPNENNEAKYVPTRENFQKVYEPAPVVESINDTPSHRRRPASEPALEAVYNSEKLSRPLSKSVEEKSESSSLPAPKDERYSYINGRYNSEPPSETTTTDATTTMYPTAMDKVALDLYAFLQQGQSNAIDAATEDASESTTVIDGELTTDSPTTTENFNPPTTTEVVTSTTTEATTTTTTTTTTTTTTTPVPTTEATTTTTQAPAGKGKFRRPGILGSSGTRNRSKSNGVSSTPATEPSLAETTQKTRGRFGSANGGSKRPKSGSKQQEEKIQKDNINAVNSEKAPPGRNRFRSTVSKPTASTTSSPVTTSSSSGIPSGVSRPSFNKINLNRRRSRPTTPTSTTNEETKNNSESPAPDDTQESTTPTTKAPVRQKFPGLSNRPGGSAPRVNLRRPGRPTTTTTTEEPKAIVEEPAGEGTEEETQETPAETSPLARLTTANPLNKLRSKNRLQVQPKSTTRAPINSPRRSPLLPRRKITEAPIVETSQENLILTNSSEPAIVDAEVTEPVLIETSTAASTKHEETRSFNGLLAPRRRLTPRRPGQILSRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MXU4</accession>
    <name>A0A8J2MXU4_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HICCMSTLAB_LOCUS11073</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NPY family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5102554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MXU4"/>
    <dbReference type="OrthoDB" id="9972427at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005179">
        <property type="term" value="F:hormone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001955">
        <property type="entry name" value="Pancreatic_hormone-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00159">
        <property type="entry name" value="Hormone_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50276">
        <property type="entry name" value="PANCREATIC_HORMONE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035302986" evidence="4">
        <location>
            <begin position="28"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAG5102554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="156" mass="18176" checksum="812E30CD23C850AD" modified="2022-05-25" version="1">MGLSDNIGSTLALIVLTTWIFGSGVTCDEPETMSRPTRPKMMANSDELRKFLDVVRDYYTVSSKARYGKRGVIPAIIVHDRPHTRVIIDSLMKTLESVKDKHREREKVFKIEKTAGTGHKRYHDNRVKQENKKNINIHTRVLFNSLLRRWLYHLKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MYT9</accession>
    <name>A0A8J2MYT9_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similar to Sac3d1: SAC3 domain-containing protein 1 (Mus musculus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS13263</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5108489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MYT9"/>
    <dbReference type="OrthoDB" id="264795at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005819">
        <property type="term" value="C:spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051298">
        <property type="term" value="P:centrosome duplication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051225">
        <property type="term" value="P:spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.990">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045107">
        <property type="entry name" value="SAC3/GANP/THP3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005062">
        <property type="entry name" value="SAC3/GANP/THP3_conserved"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12436">
        <property type="entry name" value="80 KDA MCM3-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12436:SF38">
        <property type="entry name" value="SAC3 DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03399">
        <property type="entry name" value="SAC3_GANP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAC3/GANP/THP3 conserved" evidence="1">
        <location>
            <begin position="82"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="SAC3/GANP/THP3 conserved" evidence="1">
        <location>
            <begin position="152"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5108489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="347" mass="39444" checksum="0A234A3226A7FE37" modified="2022-05-25" version="1">MCVHFFSSTAEKNITPQNVWSKMKQRVVAADIMKKYSEPCLRPIVPGPTASAKTFTSAKAPLMKPKPRPHTYAKTCLLFARNSKHTKADPAKAIKCYQRSSAGKSFADEPSELRPGPVLVLTVNYLFKKVLLRKDVDWSIIYEFAFDRTRGHLLECIKQLLVLYDDTDYANGAEIDDGKDANEQFKHRCDIEAVYLLLFLGEQSALSRGLSLPSSFKKSSVVQQALQISLAWYLKNYVQVCRKVFQLSPLLAMAISNNLSSIRRDAVQIMSAGYQSKNLVYPIEKFKEILLYNDVKKISEDCKLLGLQLVDKNIHFKNWLSKAPLTTPERLFNDTHLDELLPDIIFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-10-16" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>S6D308</accession>
    <name>S6D308_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cc_bv12.2_10.5b</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">bv12-2</name>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS1878</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2013" name="Philos. Trans. R. Soc. Lond., B, Biol. Sci." volume="368" first="20130047" last="20130047">
            <title>Functional endogenous viral elements in the genome of the parasitoid wasp Cotesia congregata: insights into the evolutionary dynamics of bracoviruses.</title>
            <authorList>
                <person name="Bezier A."/>
                <person name="Louis F."/>
                <person name="Jancek S."/>
                <person name="Periquet G."/>
                <person name="Theze J."/>
                <person name="Gyapay G."/>
                <person name="Musset K."/>
                <person name="Lesobre J."/>
                <person name="Lenoble P."/>
                <person name="Dupuy C."/>
                <person name="Gundersen-Rindal D."/>
                <person name="Herniou E.A.Drezen.J.M."/>
            </authorList>
            <dbReference type="PubMed" id="23938757"/>
            <dbReference type="DOI" id="10.1098/rstb.2013.0047"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CAJNRD030001116">
        <property type="protein sequence ID" value="CAG5075821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="HF586474">
        <property type="protein sequence ID" value="CCQ71301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S6D308"/>
    <dbReference type="OrthoDB" id="8122504at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="176"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="178"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5075821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCQ71301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="276" mass="29718" checksum="5A9F4852050A7BFD" modified="2013-10-16" version="1">MSEYQYLNSEIQVPKEWPVDIARPLFEYFVKNATICYRKGQRVVVTVENISAAVTKFENKPGYLLEKTEDINDERTFRMDLIFPAKVVMLTPKSDGVNRKEEESVQCLPMILKSNHVISSMLVMNPKFHKIMTVEPDIEKILKLKGITGPEKYNYGVETTYTIRMIKYLEDNVTEIEPTPSTSADPSTSAGPSTSAGPSTSAGPSTSAGPSTSAGPSTSAGPSTSAGPSTSAGPSTSAGPSTSAGPSTSAGPSTSQEQATDYDWNIVTYDKLSPPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-10-16" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>S6D9I4</accession>
    <name>S6D9I4_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cc_ben.3_6.3b</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">ben-3</name>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS6072</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2013" name="Philos. Trans. R. Soc. Lond., B, Biol. Sci." volume="368" first="20130047" last="20130047">
            <title>Functional endogenous viral elements in the genome of the parasitoid wasp Cotesia congregata: insights into the evolutionary dynamics of bracoviruses.</title>
            <authorList>
                <person name="Bezier A."/>
                <person name="Louis F."/>
                <person name="Jancek S."/>
                <person name="Periquet G."/>
                <person name="Theze J."/>
                <person name="Gyapay G."/>
                <person name="Musset K."/>
                <person name="Lesobre J."/>
                <person name="Lenoble P."/>
                <person name="Dupuy C."/>
                <person name="Gundersen-Rindal D."/>
                <person name="Herniou E.A.Drezen.J.M."/>
            </authorList>
            <dbReference type="PubMed" id="23938757"/>
            <dbReference type="DOI" id="10.1098/rstb.2013.0047"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5092346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="HF586472">
        <property type="protein sequence ID" value="CCQ71096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S6D9I4"/>
    <dbReference type="OrthoDB" id="10071220at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018379">
        <property type="entry name" value="BEN_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10523">
        <property type="entry name" value="BEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51457">
        <property type="entry name" value="BEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BEN" evidence="2">
        <location>
            <begin position="834"/>
            <end position="938"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="105"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="394"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="471"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="571"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="643"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="745"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="172"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="258"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="394"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="471"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="500"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="576"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="643"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="658"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="745"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="774"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="786"/>
            <end position="796"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5092346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCQ71096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="947" mass="106728" checksum="17A14ACD0A563512" modified="2013-10-16" version="1">MTRKSDKPAFYVVQFLDLPYEGIDDYVCVPHTWVMVHKVHDMKAVVTYPTGEDPSLTRDRVKRKEKCDHEWKFFMAAVKYHSNSYQNAEAWTASRNDHRLLVERETRKMPDTQPESAPNLNSRNSTQGNSSKFNDNPRKPLPRTLITRPSLPELNEQLDGKRFKLKKAAKPSSDSVTDANTESIREQSTNIQDNRSTKLTQTQETAAASKINSRTEQRTQTQRTEQNKEALSLPVIDVDGPPEVMEIDDRHHSPGIKTSNQNNSTSHSHLSDTAAVPMSATKPLTSTERNTQPYQYNNQQHILDNRNSLSIFETQLENIRSLANAHNDHELRSHEVSSNTPTTSHKVMNSLKIPAQLCDNVYGTTDFVQARNAIDKKICRRKMNRNLEIVAQNSSNLMGQPGSLSARSVEEQSSVVAQTRSQDGPRVREMHPGNSTDQTAPLWQIIINSPEIQHTPKRNAESTSNTLLASQNLPSSSYIPSTGQILTKPSNPLYQTSKFPQQRPSQSNQQDSQRQPQIPDIRTSVSNELQKETQMPTLQEVKKKVQSSVLSNLLKSMQSTLSANHNEYLRSEKQARLSQQSTEHNNRELTSSPKNVVVSTTSDKHQHVIDNTRQTGECVVKPVSPHYAVTSDSDTVTDEGILDHELSTDRAPVERINDSTSTEITPASSSADRPTTAENSTSINSSTDVRSSLEQGILNNFADLFTQISSTLRYTTDMYSTLRSSILDTAQTYKKLLGAVEQFNSTQNSADNKSFSINSKPEVRKSPKRRHTEVTASTSSITQDQHSNDDANEPPKKKYNSWRFVLPPEYDPHDTKWTLKYRTNLPGLIELRPQRGVWVSYGDLKYCQQVSKDCKSLARRLLLAVFNRKALSVCLSITERAQASDNVGSNARPELDDHACTVLLNFVLEHGLQRGWNTDIQPILNTLHSKIQEIRFKYGVVVQCHLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2E0N3</accession>
    <name>A0A8J2E0N3_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Actin-related protein 2/3 complex subunit 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HICCMSTLAB_LOCUS307</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the Arp2/3 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Cytoplasm</location>
            <location evidence="1 6">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the ARPC3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001114">
        <property type="protein sequence ID" value="CAG5073363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2E0N3"/>
    <dbReference type="OrthoDB" id="200404at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005885">
        <property type="term" value="C:Arp2/3 protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034314">
        <property type="term" value="P:Arp2/3 complex-mediated actin nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030833">
        <property type="term" value="P:regulation of actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1760.10">
        <property type="entry name" value="Actin-related protein 2/3 complex subunit 3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007204">
        <property type="entry name" value="ARPC3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036753">
        <property type="entry name" value="ARPC3_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12391">
        <property type="entry name" value="ARP2/3 COMPLEX 21 KD SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04062">
        <property type="entry name" value="P21-Arc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016315">
        <property type="entry name" value="ARP2/3_P21-Arc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69060">
        <property type="entry name" value="Arp2/3 complex 21 kDa subunit ARPC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="3 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR016315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAG5073363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="153" mass="17500" checksum="79CFFC37CFCE6EFE" modified="2022-05-25" version="1">MPAYHSSFTKSDKLLGNMAMLPLKTTFRGPAPFFNFQNEADRLLIYITLYITECLKRLQKCATHNQALTEMYSLAISKFDIPGDPGFPLNSVYAKPETSDEADKMRQYLQQIRQETAARLVEKVYSDNGKPSKWWLCFAKKKFMDKSLSGPGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2E338</accession>
    <name>A0A8J2E338_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nuclease HARBI1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS1727</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001116">
        <property type="protein sequence ID" value="CAG5075573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2E338"/>
    <dbReference type="OrthoDB" id="7547770at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5075573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="149" mass="17479" checksum="6BB92473A105255F" modified="2022-05-25" version="1">MSGEYDYQMWIYQCQKINREAQIKRLRRNRMKRFWAHLLHKLQREHGFFKTVFPTLCSYSEKFENYIRICLSLIGPQITKKNDVREPISATARLVMTLRYLATGDCITSISHQYLVGVTTTANIIAETCQSPDNSGSLFHNDKNLHVLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2E3R2</accession>
    <name>A0A8J2E3R2_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">WASP family protein member</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS2120</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001116">
        <property type="protein sequence ID" value="CAG5076139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="8965057at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23039:SF9">
        <property type="entry name" value="LOW QUALITY PROTEIN: NHS-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23039">
        <property type="entry name" value="NANCE-HORAN SYNDROME PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="264"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="361"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="474"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="765"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1314"/>
            <end position="1364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="264"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="374"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="384"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="478"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="501"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="517"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="540"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="593"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1318"/>
            <end position="1330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1332"/>
            <end position="1347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1348"/>
            <end position="1364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5076139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1612" mass="180004" checksum="C2AE4353815A057A" modified="2022-05-25" version="1">MPFVVRKIEPRYIGRGHVPQDNSCVEIWPVGAELEAIINGALACTLKQLASLLTNAQDIFQGLNDELGDVANRTESDISSFASRKKHFKSLQKPSTGLFSETTRPAALKKLYQQASVIAVRNLDYIKINHNGNDTTAVEMFLCTPILGKRRRDQSLDIESRVPALFDDLRRWTSSEALGDITVPPDCMSRIIQSNDNDFTGDDAVDHKLPSPEEQFQVIALKFPAEIVAVDISGKGFARMSMRKKLTMAQITSEFNLDNDTTVKRRSKVRHNTSRSKNKRRNTIAGTDGKEIKQNIIKEPSTTKKDNDEDDNIKETIYKSKSTKNRCVRSISTDILQERDTELTKWNFDAFKAWGRSRLRSMRRQSSDIDKNIKSTSNFGSVTDNSNNNNNNNNNNEDEINNDNNNDVKDLMVVNKVNANDELKLSEEEEEEEIKQNFSSINVNNNSVATSSIPLLLSSSSSLSATKMHTFDRNFSHQSHHQKRQQQQKHGNSSNNMLYDVRLRESAVLRRERRKGNNNNSNNNNNNNNANNTREDPIHSSSGNWSASSESGRTSSIGSEIISSNLPGRSSSSSSSSKLLSHNHGRRLKGRDTPTSSSVTSEASTLTPDIIQDIITYPGDDFETEGETCSIYSCDTEGYYTSFHMDSGLKTLREEELAAANANINNSFNNATPNYNTTTTNTNAIKTTTADIVTFNNQNQNHNQLPSNNQNGFVENEYELFGRGSTSTTTSSAGTVCTTLMAGAPPVPPERKSSLTVVAMVHGQNGGGNSPDSGHNTCSSPVESASASSPACYTARSCSELEYSESSDLEGYDRIERLRNKTAISTNRIPSMCVITPSGSDDEQAQSQQQQQQPDLNKILQLHNANSISYDELVNTSVVGVGNKIKTCQDSGDYVTIADFRNNKDRYRQENITQVYANIESKKYSLKQQQSSKKSKLLPDEFESAEYVSLSDLPKKSDCSLERKRRQGARVVLDYQGKVIYSSDSLKRRKESHTTFNPGPFIKESSPIVAATNRNDKSHPESPRGIVKPRAFVNLAHQHQQQQQQSESSIINEKIKRTAASTASTASTASTASTALTATLAELEEVKIEEKIKEEDTNWIHSQDQVDSHREKKLQDEKNNISTINYKKNLSLANKKIQYSDGLSSGEEIYHQSVVELATPDITRRNLDNNKKYGNNQSQRYLMPLNLNTYDGNSSQITTSSPLSQKFKENQPSEKMNIDRLERLERKDFLNNSTLSPIPSSNSFYSSSSINSLVKNNKTMSNDELFTAIYKSKRKLNIKNDSEISTGSTSTTTKTIDDSLIDISNYVPDDNNKIGTRHSWSPESQTNTAEQLKLSNPSLNSSSNSSKGTGRQVNYGINDNNNKQTTANSTIIIKSLNTLSTLDHQRYNSSTGSYLSRGQQKTIFPNPYQINKHDSINSFNHQKSIWKYQIPRSNILSCTIIEDVAAEETAVKQFLESPPSPLPSATCSSSSLSSLTPSATLINDSDNNVNKNKQIYKNNLKSSENNDIDNIFSNKLFEFNNSSNNDDSNNSKLVSAHFEAESLKKRNNELKAQFLSNNKLDNNIIIFDEKNQIKSGPTKDTADIITPSCHETPLHRHLKQHYKFKYQVSRQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2E6R0</accession>
    <name>A0A8J2E6R0_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ADP-ribosylation factor-like protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HICCMSTLAB_LOCUS1484</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the small GTPase superfamily. Arf family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001116">
        <property type="protein sequence ID" value="CAG5075330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2E6R0"/>
    <dbReference type="OrthoDB" id="2011769at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051649">
        <property type="term" value="P:establishment of localization in cell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048731">
        <property type="term" value="P:system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd04151">
        <property type="entry name" value="Arl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000306">
        <property type="entry name" value="ADP-ribosylation factor-like protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024156">
        <property type="entry name" value="Small_GTPase_ARF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11711">
        <property type="entry name" value="ADP RIBOSYLATION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00328">
        <property type="entry name" value="SAR1GTPBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00178">
        <property type="entry name" value="SAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7 9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0519">Myristate</keyword>
    <keyword evidence="3 7 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="7"/>
            <end position="14"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="14"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="31"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="53"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="109"/>
            <end position="112"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00040615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAG5075330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="164" mass="18417" checksum="B6DE9E146963CA64" modified="2022-05-25" version="1">MRILILGLDGAGKTTILYRLQVGEVVTTIPTIGFNVEQVTYKNLKFQVWDLGGQTSIRPYWRCYYSNTDAVIYVVDSADRDRIGISKDELLYMLREDELQGAILVVLANKQDMPGCLSVAEVHQALGLDALKNRTFQIFKTSAKKGEGLDQAMDWLANALQSRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2E7T5</accession>
    <name>A0A8J2E7T5_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS2169</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001117">
        <property type="protein sequence ID" value="CAG5076375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2E7T5"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5076375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="84" mass="9792" checksum="3F9D04F495BFD6E8" modified="2022-05-25" version="1">MDKIMTAVLEDVPRAIQLANFIRKLIDLTSRVDKLYEDYLFYVKKANNITYYTIEEFGRVVTSHKFGDIPDLLDQTYSLFIPGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2E950</accession>
    <name>A0A8J2E950_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HICCMSTLAB_LOCUS640</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="CAJNRD030001114">
        <property type="protein sequence ID" value="CAG5073859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2E950"/>
    <dbReference type="OrthoDB" id="266718at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007224">
        <property type="term" value="P:smoothened signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000042">
        <property type="entry name" value="Aurora kinase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000571">
        <property type="entry name" value="Maternal embryonic leucine zipper kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22983">
        <property type="entry name" value="PROTEIN KINASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22983:SF6">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE 36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="4"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="37"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAG5073859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="702" mass="79664" checksum="5CB57B4D255FF66E" modified="2022-05-25" version="1">MENYDLLSQIGEGSFGQVFKAKKRANDEIVAVKRIRKRGRSCKELKSLRQECEIQRYLSHPNIVRMIDSFETVDEIVVVTEYADKELYEILGKTGRFTEDRAQKVICDLVSALYYLHSNRVLHRDLKPQNVLLEANGTAKLCDFGFARIMSTRTHVLTSIKGTPLYMAPELIEEYPYDHNADLWSLGCIAYEMIVGTPPFQTTSILHLVGLIRFESIKWPEFISAKCQSFLQGLLEKIPSQRLTWPDLLEHPFVKNRILIIDSPTSFTAPLSSSEAHAKQLQFEHLSMRAINKSRTLDNNHQGCVSQPIYPLVNRFHPFVSADAYNSRQNGTSSGSTASVDVLLSNLSLRASLQSDLLSANQAAEINCTDSACMSQQLGNENINSLYDFTGYEKPDFDNKNCETSDQSPKKLPDWDARAVDQHIENDEWLAFLQQSIEEIIEGEITSLVEENCVSIFVSPLRNSSASSQVVEYIACLLSLPFVCSISPEELTRIQRVYYDVKVVPNLVCAMNIILERLQATQAEDHEELTRRDCGSIKTASMLSPEQLQALESSMLVLCRLVHSDQKFLDQFCQAVDIIGVNLLREMLTLERRKVRIVADLLAILNNTLRSLPGNVELVEKVVFGQRSETIEQLSKLLTHRQVVLKSRTCTLIRLLGRLRSKAFKQIWDRQLESLLRNLTNDEDNNVKNVASRTINELIHCT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2ECZ7</accession>
    <name>A0A8J2ECZ7_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Similar to ato: Protein atonal (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HICCMSTLAB_LOCUS1747</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001116">
        <property type="protein sequence ID" value="CAG5075593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2ECZ7"/>
    <dbReference type="OrthoDB" id="6161578at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070888">
        <property type="term" value="F:E-box binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061564">
        <property type="term" value="P:axon development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016360">
        <property type="term" value="P:sensory organ precursor cell fate determination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd19715">
        <property type="entry name" value="bHLH_TS_amos_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.280.10:FF:000025">
        <property type="entry name" value="protein atonal homolog 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050359">
        <property type="entry name" value="bHLH_transcription_factors"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19290">
        <property type="entry name" value="BASIC HELIX-LOOP-HELIX PROTEIN NEUROGENIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19290:SF169">
        <property type="entry name" value="PROTEIN ATONAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="3" id="KW-0221">Differentiation</keyword>
    <keyword evidence="4" id="KW-0524">Neurogenesis</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="9">
        <location>
            <begin position="189"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="54"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="141"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="71"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="82"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="147"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAG5075593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="246" mass="28435" checksum="C36A709A87EBD180" modified="2022-05-25" version="1">MFRYGYMFASHKQESNTPTYLELSDYSYRKEKNILLPPVSSVLTVQSRCIIYDNNESDGWHTPSPPASLRSISPSTPISQSSKDHLHSTPEKVINHQLQSKRRKIDRCELDDSNRSSYLQIRLQMSKVDEDKEDGIQMHQSEEKLSHSIGSSGSLSDHIDMDFESDGNSSDFEDSRKRSKYVNSTVVKKRRLAANARERRRMQNLNKAFDRLRAYLPSLGNDRQLSKYETLQMAQSYITALYDLLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2EDD7</accession>
    <name>A0A8J2EDD7_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS2058</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001116">
        <property type="protein sequence ID" value="CAG5076077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2EDD7"/>
    <dbReference type="OrthoDB" id="76173at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="40"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="152"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5076077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="463" mass="52578" checksum="9E1DA88D3639A759" modified="2022-05-25" version="1">MDKYDTEPRRKLGAPISGLTDKALVTPSIPDISFISPNNVHPREEVSNNYNKKSRPPRSDNFQKLKAITEHSTEVLKKQDSGNDLRFKFYQKLKESTTSIVPVNSGKIAPSIEPIYRHISGHLQQNKSHRQLNSNNCVSRSKNDNLDNYNNLKLLLSLIKSQNQQIKSLEIQINALISIHQKEKINSEKIKLAANDRHEDAKISIGVMTSLEFTVKKTPNEANLIPVIDLPSLGPRINDPVSVRVMSSKHGGNFNTYGDNDCRSNGSHSDDGCARPKGKVSSKVGWTFYNNMMCQVNEMLDTQNDGQSQQQHRYQTQQSIINDKGQQRSMMQQWKIFKATMATGLVNYQTNIVQTTNSIVDDNTSIHMQALALKYLGHNSESPNLQTLTKLMSVISTPINDGNNYNNNTDKLLNNIINDERYRQLLTLEDNSVYNYKGKKQNRQNLDISVLKRQPNTQKYDIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2EF10</accession>
    <name>A0A8J2EF10_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similar to grip2: Glutamate receptor-interacting protein 2 (Xenopus laevis)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS206</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001049">
        <property type="protein sequence ID" value="CAG5073022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2EF10"/>
    <dbReference type="OrthoDB" id="75502at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0675">Receptor</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDZ" evidence="1">
        <location>
            <begin position="7"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5073022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="94" mass="10377" checksum="FFBC6DCF32DC1C21" modified="2022-05-25" version="1">MRSGIFTVRLIRPVGGQSELGITINEDLIISEVKRASLAYRTGSLIPGDQLLAINGQILCLSDYRKITHIIKHLKNSTVALTVKRPTIGTTTRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2EHG2</accession>
    <name>A0A8J2EHG2_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Similar to TRYP1: Trypsin-1 (Anopheles gambiae)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HICCMSTLAB_LOCUS1763</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001116">
        <property type="protein sequence ID" value="CAG5075609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2EHG2"/>
    <dbReference type="OrthoDB" id="10059102at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000077">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050430">
        <property type="entry name" value="Peptidase_S1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033116">
        <property type="entry name" value="TRYPSIN_SER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24276:SF91">
        <property type="entry name" value="AT26814P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24276">
        <property type="entry name" value="POLYSERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00135">
        <property type="entry name" value="TRYPSIN_SER"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 8" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0720">Serine protease</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0865">Zymogen</keyword>
    <feature type="domain" description="Peptidase S1" evidence="10">
        <location>
            <begin position="105"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="10">
        <location>
            <begin position="351"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="43"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="45"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAG5075609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="580" mass="63412" checksum="EC2B587EACF36DB4" modified="2022-05-25" version="1">MGRAHFSGRKFKHQKYNTLRACSNCLANGKFQRLEDNPKKRVVISSSNNNNNNNNGDQSKDNNHGKNMKGRSYLRMSRRNQQKSKSVVISAHPNYLPRDLSDGRIVGGEDIEIEDVPYQVSVLVRGRHKCGGTIISDYWVLTAAHCAQFSQRMYSVRAGTVWKNQGGTIYEVDKVVNHENYRLIFDIPMDDIALLRLATPFVFGEACQPIDLPNKGEKVKPETQTVVTGWGDTKSFPFNGRLQMVVIPTISIESCREAYNFTKIPDEGRICAMTPDGGKDACQGDSGGPMVVDKRLVGIVSWGVECAVKGNPGIYTEYRQVLLIATILAVGMVNAIHWFPMMNPLTPNGRIVGGEPIDIREVPHQVSLQAYGFAFCGGTIVAEDWVLTAAHCAVYSASTITVRAGTTTKGSGGTIHTVSKIITHEDYTTNRYGIPINDVALIKLATPFEVDEFRQPIDLFEFKEEAIEGIQSTITGWGATVEGGSTPDVLNTVDVPIINKSECHDAYISFGGLPEGQICAAYPEGGKDACQGDSGGPLTIDGRLAGIVSWGNGCARPGYPGVYTEVASFRDWIDIKISTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2EHQ1</accession>
    <name>A0A8J2EHQ1_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RBR-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="3">2.3.2.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HICCMSTLAB_LOCUS1929</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.31"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RBR family. Ariadne subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.31" evidence="3"/>
    <dbReference type="EMBL" id="CAJNRD030001116">
        <property type="protein sequence ID" value="CAG5075922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2EHQ1"/>
    <dbReference type="OrthoDB" id="6748270at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20343">
        <property type="entry name" value="BRcat_RBR_HHARI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16626">
        <property type="entry name" value="RING-HC_RBR_HHARI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1750:FF:000002">
        <property type="entry name" value="RBR-type E3 ubiquitin transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000019">
        <property type="entry name" value="RBR-type E3 ubiquitin transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031127">
        <property type="entry name" value="E3_UB_ligase_RBR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002867">
        <property type="entry name" value="IBR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044066">
        <property type="entry name" value="TRIAD_supradom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018957">
        <property type="entry name" value="Znf_C3HC4_RING-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11685">
        <property type="entry name" value="RBR FAMILY RING FINGER AND IBR DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01485">
        <property type="entry name" value="IBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22191">
        <property type="entry name" value="IBR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00097">
        <property type="entry name" value="zf-C3HC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00647">
        <property type="entry name" value="IBR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51873">
        <property type="entry name" value="TRIAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="12">
        <location>
            <begin position="22"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="11">
        <location>
            <begin position="26"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAG5075922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="392" mass="46093" checksum="03583015DA8E5175" modified="2022-05-25" version="1">MHLQGQPFSEFFSFQIQQSSDSTEFCEICLSPFPRSLMTGLECGHRFCGDCWTEYLSVKVMSEGECFSISCPAHKCKILVDDASAMALIKDSKVRSKYQCLITQSFVECNRLLKWCPAPDCNRAVKVQYVNFKPVKCTCGRRFCYKCSKTWHAPILCEYMRKWAKTVAEDLSISLWIRINTKNCPKCYVAIEKNGGCNHMTCRICQHHFCWICSVNWFDHGYNTRCNRYVEAEEVNQEPDTPMPNLNTFHRTRFIYHFNFLEQERNLMMDVQNKCQRLPMSWTEVFTLQAVMTKAVNVLRQTRETLMYSYVFAYFVEKSNQKTIFEFNLQGIENTTDSLSHYLKMHIVNAEVDVIIRKVQNRTQYCDQFCRVLLDHVNEGYDKGWWTHLETA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2EI68</accession>
    <name>A0A8J2EI68_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HICCMSTLAB_LOCUS2248</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle</location>
            <location evidence="1">Autophagosome</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="CAJNRD030001117">
        <property type="protein sequence ID" value="CAG5076675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2EI68"/>
    <dbReference type="OrthoDB" id="242910at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005776">
        <property type="term" value="C:autophagosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071561">
        <property type="term" value="C:nucleus-vacuole junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034271">
        <property type="term" value="C:phosphatidylinositol 3-kinase complex, class III, type I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034272">
        <property type="term" value="C:phosphatidylinositol 3-kinase complex, class III, type II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045324">
        <property type="term" value="P:late endosome to vacuole transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016236">
        <property type="term" value="P:macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000342">
        <property type="entry name" value="Serine/threonine-protein kinase VPS15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055231">
        <property type="entry name" value="2AA_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045162">
        <property type="entry name" value="Vps15-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17583">
        <property type="entry name" value="PHOSPHOINOSITIDE 3-KINASE REGULATORY SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17583:SF0">
        <property type="entry name" value="PHOSPHOINOSITIDE 3-KINASE REGULATORY SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22956">
        <property type="entry name" value="VPS15-like_hel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 10" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="26"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="10">
        <location>
            <begin position="878"/>
            <end position="910"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="10">
        <location>
            <begin position="1140"/>
            <end position="1163"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="10">
        <location>
            <begin position="1220"/>
            <end position="1250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="199"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAG5076675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="1250" mass="139728" checksum="784D1190BB1E0956" modified="2022-05-25" version="1">MGNQLVGIAPSQIFPVEHYLTDHSDLLFDINLGSTRFFKVARARSQEGLIVVKVFVIHDPTLPLSTYNDKLEEIRSKLASAVNCLPFQRTILTEKAGFIMREYVKYSLYDRISTRPFLSNIEKKWITFQVLYALHQAHKFGVCHGDIKLENIMITSWNWVLLTDFASFKPTYLPEDNPADFSYFFDTSRRSMKKSINGSNIELSREDSAEPSEENTIIEGDSDQSFDKSDANTTSDTKLSKHDNNKAVNLNSEETLGTLQRDVEADLEEFKIKSDKLEGLIIITQLVTSCIRGLHHSQSKLQSLEILLELAENTSDETILDRILPYIFHLVHDPAPRVRVSAIHTLTKCLYLVKSIPPTDVNIFPEYILPGLAHVTQDEAVIVRAAYAENIAHLAHIALRYLENAHLTNLGNKEGPKPSYDSELQTLHEMVQQSVSMLLTDSSNLVKQTLMESGINKLCVFFGKQKANDVLLSHVITFLNDKEDKQLRGSFFECIVGVAAYVGWHSSPILMPLLQQGLTDPEEFVTRKAINAMATLTELGLLHKSALYQLLSETVVFLVHPNLWIRHATVGLISAAARTLNLVDVQCKVQAMIQPYLKHSLIQIEKEVLVLEALIQPIPRVVYDSVIKYHDVEELFRAFEERKAARSKAITGSVPQYSETSTSLRNLFRRLSSESMTEIVEDQLLAMKSHLIKINKYRISADNKHNAMKSVTEGKLELSMIKDSIRHHVVVLYPDSKNDIAVNYKKFDRRTSDSTGNYTMNQEWRTMFAAQDNNHSNKMSELTSSSPSPTIHSGDIHLSPQHSLTDINSMNDHSLHERSYIQYRCAPCRLELRQLTCRKQEQHAAALRAQHWADNMAWHGTRLLSSSWRPRGVPVAYLHEHRAAVNRLVSIPDSGLFASSAADGCVRVWDASKMEGKNLANRSRQTYVHRGGPLVGLAVCEQGQSLASSASQSGSLFVLRLDNGTSKMNVVSSKQLDVTNEGCAVDLQYLDSGSQSVLVYATLYGSLIGWDLRCPGTAWRLENDLKHGVITSFCVNNYQQWLALGTSSGAHICWDLRFQLPISNIKHPTGARVRKVITHPTEQSWIISSVQGNNEISMWNLETGFRQMVLWASSAPPLSHSQEGHSICGMHAGSTDRSGFLLAGGTDMRLRFWDLNTPNESYVALPAASDTIAPNSLAYEQRLIDGTNVVQEVIAATGPISTGARVRSEEGVAPPLEVPNPGHHDTISAVAMSNTCILTGSTDGLIQVWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2EIT2</accession>
    <name>A0A8J2EIT2_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Polypeptide N-acetylgalactosaminyltransferase</fullName>
            <ecNumber evidence="16">2.4.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Protein-UDP acetylgalactosaminyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">HICCMSTLAB_LOCUS703</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 16">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 16">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 16">Golgi apparatus membrane</location>
            <topology evidence="2 16">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 16">Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="16"/>
    <dbReference type="EMBL" id="CAJNRD030001114">
        <property type="protein sequence ID" value="CAG5073931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2EIT2"/>
    <dbReference type="OrthoDB" id="429263at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004653">
        <property type="term" value="F:polypeptide N-acetylgalactosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006493">
        <property type="term" value="P:protein O-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd23434">
        <property type="entry name" value="beta-trefoil_Ricin_GALNT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02510">
        <property type="entry name" value="pp-GalNAc-T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.80.10.50:FF:000065">
        <property type="entry name" value="Polypeptide N-acetylgalactosaminyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000021">
        <property type="entry name" value="Polypeptide N-acetylgalactosaminyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045885">
        <property type="entry name" value="GalNAc-T"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000772">
        <property type="entry name" value="Ricin_B_lectin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11675">
        <property type="entry name" value="N-ACETYLGALACTOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11675:SF119">
        <property type="entry name" value="POLYPEPTIDE N-ACETYLGALACTOSAMINYLTRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00652">
        <property type="entry name" value="Ricin_B_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00458">
        <property type="entry name" value="RICIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="Ricin B-like lectins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50231">
        <property type="entry name" value="RICIN_B_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14 16" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 16" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="12 16" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 16" id="KW-0430">Lectin</keyword>
    <keyword evidence="15 16" id="KW-0464">Manganese</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="6 16" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Ricin B lectin" evidence="17">
        <location>
            <begin position="325"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU361242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM00458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="CAG5073931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="447" mass="51018" checksum="62BE348EC9A8A26E" modified="2022-05-25" version="1">MERCRLKQWRRDLPPTSVIITFHNEARSTLLRTVVSVLNRSPEHLIKEIILVDDFSDHPEDGEELSKIHKVRVIRNEKREGLMRSRVRGADAATASVLTFLDSHCECNADWLEPLLERVAEDPSRVVCPVIDVISMDTFQYIGASADLRGGFDWSLVFKWEYLSQAERQSRQKDPTQAIRTPMIAGGLFVIDKAYFEQLGKYDTQMDVWGGENLEISFRVWQCGGSLEIIPCSRVGHVFRKRHPYSFPGGSGNVFARNTRRAAEVWMDDYKHFYYNAVPLARNIPYGNIADRLDLKRKLHCKPFSWYLKNVYPELVIPTSEGGPGGSLKQGHSCLDSMGHLLDGNVGLYPCHDTGGNQEWSLTKDGLIKHHELCLTLPMYAKGTTLLMQVCDGSENQKWRYLEGGLIRHSRIPVCMDSKFHAQRGITAEKCDSSVESQRWHLYNHGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2EKC3</accession>
    <name>A0A8J2EKC3_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Similar to Rufy2: RUN and FYVE domain-containing protein 2 (Mus musculus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HICCMSTLAB_LOCUS1862</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001116">
        <property type="protein sequence ID" value="CAG5075789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2EKC3"/>
    <dbReference type="OrthoDB" id="79871at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15721">
        <property type="entry name" value="FYVE_RUFY1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17681">
        <property type="entry name" value="RUN_RUFY1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.900:FF:000011">
        <property type="entry name" value="Uncharacterized protein, isoform B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.900">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047335">
        <property type="entry name" value="RUFY1-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004012">
        <property type="entry name" value="Run_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037213">
        <property type="entry name" value="Run_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000306">
        <property type="entry name" value="Znf_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45956">
        <property type="entry name" value="RUN AND FYVE DOMAIN-CONTAINING PROTEIN 2-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45956:SF6">
        <property type="entry name" value="RUN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01363">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02759">
        <property type="entry name" value="RUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00064">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00593">
        <property type="entry name" value="RUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140741">
        <property type="entry name" value="RUN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50826">
        <property type="entry name" value="RUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RUN" evidence="9">
        <location>
            <begin position="150"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="FYVE-type" evidence="8">
        <location>
            <begin position="685"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="467"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="292"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="472"/>
            <end position="482"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAG5075789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="751" mass="85463" checksum="19219A978456F5B4" modified="2022-05-25" version="1">MSENTSAVSPSDKSLSGSMLSDDIEGVSRSPSTYSIREDKWPDLVVSRPRKLDAWWSPRRAMIDQDMAGAQDTIYLCNFRVSVDGEWLCLKELQDVEFSMQDSMQRSPSPPLAISARDPVIIERSNLVNISKLIVKELIETSLKYGRMLDSDHMPLQHFFIVLEHVLRHGLRPKKGLLGPKKELWDILQLVEKYCPEAQDITASIRDLPTVRTAMGRARAWLRMALMQKKLADYLKILIDHRDDLLSEYFEPDALMMSEEAIVIMGLLVGLNVIDCNFCVKKILIVSKGATVKNLQAKVESLTTTNALMKEDLSIARNNILSIQEENRQLKKELGIEVKDTVETGKTPIKITETTSEIEELRSRLESEKKLRSDVEKELALQVSMKSEMEVAMKLLEKDIHEKQDTIISLRRQLEDIKLINLEMYKKLQECEVELTQKGEMVSRLHAKTNQIGKILNNLEKYNHLMKDSDGRTPTTPSSTKSFVKISPLSPKPPPFAELGTFRDRDFRAEKAAKDCESSLKHKTEVIVKLEAQTLSMSETIQKMDQKCKEIDNVRSGSEERARLLDAKVAEREARANGMERELKVEREWRTSLQEASVSNTEKISQLLQEIDQLKSVHEKYLTLQEEHYALREICTEQERTLEELGGQLSLAKLAACELREAVDNAQYQAANNEGTNGTPTWANDRLVTNCKGCNREFNLTRRKHHCRNCGKIFCNACSDNTIALPNSAKPVRVCDECHVFLVGRYSVLTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2EKX8</accession>
    <name>A0A8J2EKX8_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Lipase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HICCMSTLAB_LOCUS2256</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the AB hydrolase superfamily. Lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001117">
        <property type="protein sequence ID" value="CAG5076707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2EKX8"/>
    <dbReference type="OrthoDB" id="9974421at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000057">
        <property type="entry name" value="Lipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025483">
        <property type="entry name" value="Lipase_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11005">
        <property type="entry name" value="LYSOSOMAL ACID LIPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000862">
        <property type="entry name" value="Steryl_ester_lip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 7" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="9">
        <location>
            <begin position="97"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="8">
        <location>
            <position position="189"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="8">
        <location>
            <position position="360"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="8">
        <location>
            <position position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR000862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000862-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAG5076707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="416" mass="47937" checksum="43B5440E01B8A8EA" modified="2022-05-25" version="1">MPYTRSNCIIFVLFLSLIYSVKLLWCLNLLPQERMLKVRTLREANSSNTVLDFIGIAKEFGYKAEQHNLTTSDGYILQIFRIPKGKFHYQEERNGKPVILLEHGLLASADIWAALRRSLVYVLADAGYDVWLGNVRGNCYGRAHKTLSPEDPKFWNFTFHEYGAIDYADTIDYVLETTNKTTLTYIGHSMGGTSIVILLSEKPEFNEKLNAVIALSPTVYWKKKDPLRNLFTSTFYGIGQMIDPTGMSEFLPQSTLVRNLLTDYCETLNLVDACILILKLFIGFDDDQMDNNEMIYLSNYYPAGTSTKSMYHYCQCAITGEFSKYNYDKNNINYYNQEEPPAYKVKNIIAPMVIFYGENDPLSTLVDNRELIRRVTSNVTLIKIDYNKFTHLDFVIAKDVKKFFYAKLIDVLSKYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2GZD2</accession>
    <name>A0A8J2GZD2_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Mutator-like transposase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS358</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001114">
        <property type="protein sequence ID" value="CAG5073415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2GZD2"/>
    <dbReference type="OrthoDB" id="7698403at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049012">
        <property type="entry name" value="Mutator_transp_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20700">
        <property type="entry name" value="Mutator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mutator-like transposase" evidence="1">
        <location>
            <begin position="19"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5073415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="92" mass="10582" checksum="61A998D43E0F748F" modified="2022-05-25" version="1">MNLKISEFLDQTSKQKYRAIHSGVGNTSLNKILACENLPQMRRQQYKKYESIVGKAIESEARDSCKRAASEERDRAHADKIIITNHIFTPIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2GZT9</accession>
    <name>A0A8J2GZT9_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Regulator of telomere elongation helicase 1 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">HICCMSTLAB_LOCUS1100</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001116">
        <property type="protein sequence ID" value="CAG5074875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2GZT9"/>
    <dbReference type="OrthoDB" id="19182at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070182">
        <property type="term" value="F:DNA polymerase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016818">
        <property type="term" value="F:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045910">
        <property type="term" value="P:negative regulation of DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904430">
        <property type="term" value="P:negative regulation of t-circle formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010569">
        <property type="term" value="P:regulation of double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090657">
        <property type="term" value="P:telomeric loop disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18788">
        <property type="entry name" value="SF2_C_XPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000431">
        <property type="entry name" value="Regulator of telomere elongation helicase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03065">
        <property type="entry name" value="RTEL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006555">
        <property type="entry name" value="ATP-dep_Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045028">
        <property type="entry name" value="DinG/Rad3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014013">
        <property type="entry name" value="Helic_SF1/SF2_ATP-bd_DinG/Rad3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006554">
        <property type="entry name" value="Helicase-like_DEXD_c2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010614">
        <property type="entry name" value="RAD3-like_helicase_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013020">
        <property type="entry name" value="Rad3/Chl1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030845">
        <property type="entry name" value="RTEL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057498">
        <property type="entry name" value="Rtel1_ARCH"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00604">
        <property type="entry name" value="rad3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11472">
        <property type="entry name" value="DNA REPAIR DEAD HELICASE RAD3/XP-D SUBFAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11472:SF34">
        <property type="entry name" value="REGULATOR OF TELOMERE ELONGATION HELICASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23109">
        <property type="entry name" value="ARCH_RTEL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06733">
        <property type="entry name" value="DEAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13307">
        <property type="entry name" value="Helicase_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23116">
        <property type="entry name" value="HHD_RTEL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00488">
        <property type="entry name" value="DEXDc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00491">
        <property type="entry name" value="HELICc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51193">
        <property type="entry name" value="HELICASE_ATP_BIND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="12" id="KW-0234">DNA repair</keyword>
    <keyword evidence="11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7 19" id="KW-0347">Helicase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="13" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="18">
        <location>
            <begin position="11"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="84"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="19">
        <location>
            <position position="904"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00073810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="CAG5074875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="904" mass="101852" checksum="5F8668A45F345E1C" modified="2022-05-25" version="1" fragment="single">IIVKMPDIKLNNIIVNFPFEPYEVQKVYMSKVIECLQNKKHGVLESPTARKAHLQAQSLVGAIDSPDFGGDFFKRLKKDLQMASSGGGAAEANPEAPSQSPASFGWSQPKIIYASRTHSQLTQVMGELKRTNFKHLKVAVIGSRDQLCIHPEISKESNSADKIHLCQSKVRTRSCMYYNNVETKKEEAVFKDTICDIEDLVKNGTKHKCCPYFMAKELKQSADITFMPYNYLLDPKTRRSQGIDLQNHVILLDEAHNVEKTCEESASLQISSTDIALCIDEVTSVMKRLLEEDLEVGGGFEVEKEAKDFTPDDLCTLKSIFLGLEAAVDQLEIKDEKGDTYPGSFIFELLESAQLVGNHLQVAEKLDKVVLWLATTSTSPFARTGRALQKFADFVRTVFTSSLPPDSWTSTKVNSSGKLISYWCFSPGFGMRQLLELGAHSIILTSGTLSPLKPFITELGIPIEIVLENPHIIPSKQISIGVLSNGPDGQVLNSSFNTRNDPKYISSLGRTILNFSNLIPDGLLVFFPSYPIMKKCVEDWQQAGLWSSLVSKKPVFIEPQGKDTFNAVISEFYGKIKAPESRGAIFLAVCRGKVSEGLDFSDDYGRAVLVTGLPYPPMMDPRVLLKQRYLDEIRKKNKEGLTGGQWYQLEASRAVNQAVGRIIRHIGDYGAIILCDTRFNSPQFKEHLSKWLKPHLKNYQNFGIVTRELRDFFKNVGECKRNFRELPTVGKKVAKLTANLGGEKVKEEKVDFGAYKMEAKKVEGSVNFVTSKVQGQWSARTWESTKEEGEGVVKKRKIKIQKLEVNYKDDKTVCEEETAGKEDDKKLVGQKYLKSVKKGLSKENFKVFAKMIESYRAEGDFNELIKTLEMLFMEGMKELIVGFRTFLKKQHVEEFEEFCRRKGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H040</accession>
    <name>A0A8J2H040_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Similar to Tubulin alpha-8 chain (Gallus gallus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HICCMSTLAB_LOCUS1489</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the tubulin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001116">
        <property type="protein sequence ID" value="CAG5075335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H040"/>
    <dbReference type="OrthoDB" id="1844at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.20">
        <property type="entry name" value="Tubulin/FtsZ, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="entry name" value="Tubulin/FtsZ, GTPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002452">
        <property type="entry name" value="Alpha_tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008280">
        <property type="entry name" value="Tub_FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000217">
        <property type="entry name" value="Tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037103">
        <property type="entry name" value="Tubulin/FtsZ-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018316">
        <property type="entry name" value="Tubulin/FtsZ_2-layer-sand-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017975">
        <property type="entry name" value="Tubulin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11588">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03953">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01162">
        <property type="entry name" value="ALPHATUBULIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00864">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00865">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55307">
        <property type="entry name" value="Tubulin C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="Tubulin nucleotide-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00227">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0493">Microtubule</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubulin/FtsZ GTPase" evidence="7">
        <location>
            <begin position="10"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="Tubulin/FtsZ 2-layer sandwich" evidence="8">
        <location>
            <begin position="173"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAG5075335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="346" mass="38339" checksum="B0DA9940F936C8AB" modified="2022-05-25" version="1">MSNTEGEILTIFVGQSGVQVGNACWELFCLEHGIKPDGFVVQGYDTDDNSYQTFFSPSQSQQSFGGGTGSGFTTLLLENIKQDYDKLTKLDFSIYPAPHISTSVVEPYNALLTTHGTVDYEDCCFIVDNEALYDICSNNLEVERPTYTNLNRLQSQVVSAATASLRFEGSPNVRLDELQTNLVPYPRIHFPLITYSPIITARQASNVDMNVMHITNECFQPSNQLVKCDPRDGAYMSCCLLYRGNINPNDVNQSIKLLKEKKDVRFVNWSPTGFKMLIGGAVSYVAGKQAARTIYWRTLNNGRLLKTAKTCMFQGPPKSAPSSTSALVSPSIQSTIDVLPKSIFKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H204</accession>
    <name>A0A8J2H204_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Similar to gl: Protein glass (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">HICCMSTLAB_LOCUS905</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001114">
        <property type="protein sequence ID" value="CAG5074133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H204"/>
    <dbReference type="OrthoDB" id="6077919at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001480">
        <property type="entry name" value="Si:cabz01071911.3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000110">
        <property type="entry name" value="Zinc finger protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000634">
        <property type="entry name" value="Zinc finger X-chromosomal protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050331">
        <property type="entry name" value="Zinc_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515:SF49">
        <property type="entry name" value="GASTRULA ZINC FINGER PROTEIN XLCGF49.1-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515">
        <property type="entry name" value="PR DOMAIN ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="286"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="314"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="342"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="370"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="398"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="12"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="177"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="463"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="19"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="193"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="232"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="258"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="488"/>
            <end position="497"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CAG5074133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="497" mass="53782" checksum="4BB8A15687D96132" modified="2022-05-25" version="1">MFSLVPIKQEYSSVEEENQSASNGLQNNLHHHHHHHHPQEYPPPLFTHQDVEYMYRQLPQFWSQSQMQSAAAAAGHIDASLNKTTGQHNLTQHSERLPGPSYIHQETVYTQDPKGTREHPACLPSSESSQILLSPPPIPAHSMANHTIAFMRSQSFPVRHNGPGRPPKNSLIIPTLTPLGTAFPRPGHMVNPSVPGTTSSPSTTTGTSTIDTTSTLDTSSSRNSDTSTPGLPGTPGPGLPGTPGPSGSNGPNGPNGPIGPNSGSGNPGGSTSSSTAASPAKIKPKCQCEVCYKEFGHKSNLFIHMRTHNGERPYKCNQCDKCFTHSGNLAIHMRTHSGERPYACQICGKMFSHSGNLSTHLRTHSGVKPYKCSVCGKEFRHSGNLSIHERIHSGIKPFQCKICGKEFYHSGNLTTHMKKHPMDKDSLGPGPVGRGHGHPIVVDDQQVEVQIDGSSQMDAVMDSTMDEEERLDPSAACSAEISEADEHEAERVYEPSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H2P4</accession>
    <name>A0A8J2H2P4_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Endonuclease/exonuclease/phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS1552</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001116">
        <property type="protein sequence ID" value="CAG5075398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H2P4"/>
    <dbReference type="OrthoDB" id="7554612at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5075398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="427" mass="45909" checksum="8354994609E3C2A1" modified="2022-05-25" version="1">MDPARPGTGTTGPGPGTKSTTPAKNDRRPRRKQRLEMVLINPGESKSSGDVRRALRSGLHPEELGLGVKAVRSARKGGLLIEFEGSVKDRSALGNKITEVAGEDVEVRHLAPTATLVIDGMDFATTVEEVKAALAEAIGETADGLNVSITKPNKWGSVRAFIEAGIGAAAALETLGEVKVGWLPARAGQGRTGAVAAGGVVRWITSQIPVPSLCAAISVKRWEAGKPLITWRVLDGVRPIGRYSKRKMAKKLQVNLHRCKLVLDLLYARNRDNGMDIVLVSEQYHSVSGPNCGARDGIVWVETPAVTFVSCYFTFSEPSADFRKKVDNLERVVRHLDGEIVIGGNFNAKGKIHLRMPGLGVGARARCWCLGMSDSEVNVILQQYRLNILLSPFPIDVTGKTIGTALALLRSSPCCVSRHLLLVTTGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H4Z9</accession>
    <name>A0A8J2H4Z9_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS480</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001114">
        <property type="protein sequence ID" value="CAG5073537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H4Z9"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035276845" evidence="1">
        <location>
            <begin position="17"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5073537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="106" mass="12077" checksum="E36C4FB12DFA5A14" modified="2022-05-25" version="1">MCKLFLISVILTSSLSFEKDLNVVKFVEDCWEKLVAEGRTRRAPNRGDYYVNCARVQTSDVLAEREQCNMYNLLYELFCPKRITAAFMPNNAFQGVLPSGQCPGEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H625</accession>
    <name>A0A8J2H625_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Clathrin heavy chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HICCMSTLAB_LOCUS2566</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Clathrin is the major protein of the polyhedral coat of coated pits and vesicles.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasmic vesicle membrane</location>
            <topology evidence="6">Peripheral membrane protein</topology>
            <orientation evidence="6">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Membrane</location>
            <location evidence="6">Coated pit</location>
            <topology evidence="6">Peripheral membrane protein</topology>
            <orientation evidence="6">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the clathrin heavy chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001117">
        <property type="protein sequence ID" value="CAG5077819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2113814at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030132">
        <property type="term" value="C:clathrin coat of coated pit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030130">
        <property type="term" value="C:clathrin coat of trans-Golgi network vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071439">
        <property type="term" value="C:clathrin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045334">
        <property type="term" value="C:clathrin-coated endocytic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032051">
        <property type="term" value="F:clathrin light chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045807">
        <property type="term" value="P:positive regulation of endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006898">
        <property type="term" value="P:receptor-mediated endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016050">
        <property type="term" value="P:vesicle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000001">
        <property type="entry name" value="Clathrin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000002">
        <property type="entry name" value="Clathrin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000007">
        <property type="entry name" value="Clathrin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000095">
        <property type="entry name" value="Clathrin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.110:FF:000001">
        <property type="entry name" value="Clathrin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.110">
        <property type="entry name" value="Clathrin heavy-chain terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055358">
        <property type="entry name" value="CHCR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000547">
        <property type="entry name" value="Clathrin_H-chain/VPS_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015348">
        <property type="entry name" value="Clathrin_H-chain_linker_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016025">
        <property type="entry name" value="Clathrin_H-chain_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022365">
        <property type="entry name" value="Clathrin_H-chain_propeller_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016341">
        <property type="entry name" value="Clathrin_heavy_chain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10292:SF1">
        <property type="entry name" value="CLATHRIN HEAVY CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10292">
        <property type="entry name" value="CLATHRIN HEAVY CHAIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00637">
        <property type="entry name" value="Clathrin"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09268">
        <property type="entry name" value="Clathrin-link"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13838">
        <property type="entry name" value="Clathrin_H_link"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01394">
        <property type="entry name" value="Clathrin_propel"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002290">
        <property type="entry name" value="Clathrin_H_chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00299">
        <property type="entry name" value="CLH"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50989">
        <property type="entry name" value="Clathrin heavy-chain terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50236">
        <property type="entry name" value="CHCR"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0168">Coated pit</keyword>
    <keyword evidence="5 6" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="3 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Clathrin heavy chain linker core motif" evidence="8">
        <location>
            <begin position="331"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="repeat" description="CHCR" evidence="7">
        <location>
            <begin position="537"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="repeat" description="CHCR" evidence="7">
        <location>
            <begin position="686"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="repeat" description="CHCR" evidence="7">
        <location>
            <begin position="827"/>
            <end position="966"/>
        </location>
    </feature>
    <feature type="repeat" description="CHCR" evidence="7">
        <location>
            <begin position="973"/>
            <end position="1118"/>
        </location>
    </feature>
    <feature type="repeat" description="CHCR" evidence="7">
        <location>
            <begin position="1122"/>
            <end position="1263"/>
        </location>
    </feature>
    <feature type="repeat" description="CHCR" evidence="7">
        <location>
            <begin position="1268"/>
            <end position="1414"/>
        </location>
    </feature>
    <feature type="repeat" description="CHCR" evidence="7">
        <location>
            <begin position="1417"/>
            <end position="1567"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR002290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF09268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAG5077819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="1630" mass="186128" checksum="F0E38B21B6E21CD7" modified="2022-05-25" version="1">MSQLLPIRFQEHLQLTAVGINANNVSFNTLTMESDKFICVREKVGDTSQVVIVDLNDTANPIRRPISADSAIMNPASKVIALKAQKTLQIFNIEMKSKMKAHTMTEDVVFWKWISLNTLALVTDQSVYHWSMEGDSTPTRVFDRHASLNGCQIINYRTDPKQTWLLLIGISAQHNRVVGAMHLYSVERKCSQPIEGHAASFAQFKMEGNAEPSNLFCFAVRTTQGAKLHIIEVGQPPAGNAPFPKKAVDVFFPAEASNDFPVAMQVSSKYDVIYLITKYGYIHMYDIESATCIFMNRISGETIFVTAPHEASGGIIGVNRKGQVLSVSVEEENIIPYINGVLQNPELALRMAVRNNLSGAEDLFVRKFNMLFQNGQYAEAAKVAANAPKGILRTPATIQRFQQVPTTQGLTSPLLQYFGILLDQGQLNKFESLELCRPVLVQGRKQLLEKWLKEDKLECSEELGDLVKQADPTLALSVYLRANVPNKVIQCFAETGQFQKIVLYAKKVSYTPDYIFLLRNVMRINPDQGVAFAQMLVQDDEPLADINQIVDIFMEQNMVQQCTAFLLDALKNNRPSEGALQTRLLEMNLMSAPQVADAILGNQMFTHYDRAHVAQLCEKAGLLQRALEHYTDLYDIKRAVVHTHLLSADWLVGFFGTLSVEDSLECLKAMMTANIRQNLQICVQIATKYHEQLTTKALIDLFESFKSYEGLFYFLGSIVNFSQDQEVHFKYIQAACKIGQIKEVERICRESHCYNAERVKNFLKEAKLSDQLPLIIVCDRFDFVHDLVLYLYRNNLQKYIEIYVQKVFVIGGLLDVDCSEDIIKNLILVVRGQFSTDELVEEVEKRNRLKLLLPWLESRVHEGCIEPATHNALAKIYIDSNNNPERFLKENQFYDSRVVGKYCEKRDPHLACIAYERGQCDRELISVCNENSLFKSEARYLVRRRNPDLWAEVLLESNPYKRPLIDQVVQTALSETQDPEDISVTVKAFMTADLPNELIEILEKIILDSSIFSDHRNLQNLLILTAIKVDRTRVMEYINRLDNYDAPDIAKIAITSKLYEEAFAIFKKFDVNTSAIQVLIEQVGNLDRAYEFAERCNEPAVWSQLAQAQLQQELVKEAIDSFIKADDPSAYVDVVETAHRTSHWEDLVRYLQMARKKARESFIESELIYAYARTNRLADLEEFISGPNHADIQKIGDRCFEDKMYDAAKLLYNNVSNFARLAITLVHLKEFQGAVDSARKANSTRTWKEVCFACVDSGEFRLAQMCGLHIVVHADELEDLINYYQDRGHFEELINLLEAALGLERAHMGMFTELAILYSKYKPQRMREHLELFWSRVNIPKVLRAAESAHLWAELVFLYDKYEEYDNAVLAMMQHPTEAWREGHFKDVITKVANVELYYKAIQFYLDYKPLLLNDILLVLSPRMDHTRAVGHFTRTGHLQLVKPYLRSVQALNNKAINEALNGLLIDEEDYQGLRTSIDAFDNFDNIALAQQLEKHELIEFRRIAAYLYKERGSKDCFAACLFYCYDLLHPDVILELAWKHRIIPFAMPYLIQVMREYITKVDKLEEAESRRAEETSHEEHKPMIMPEPQLMLTAGPGMMAPGYAPQAVYTPAPGVYAPAAAAAYQGYGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H694</accession>
    <name>A0A8J2H694_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="14">CYP4G132</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">HICCMSTLAB_LOCUS2585</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="2">May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Endoplasmic reticulum membrane</location>
            <topology evidence="4">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Microsome membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 12">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001117">
        <property type="protein sequence ID" value="CAG5077895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H694"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20628">
        <property type="entry name" value="CYP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050196">
        <property type="entry name" value="Cytochrome_P450_Monoox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24291:SF106">
        <property type="entry name" value="CYTOCHROME P450 4G1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24291">
        <property type="entry name" value="CYTOCHROME P450 FAMILY 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11 12" id="KW-0349">Heme</keyword>
    <keyword evidence="9 11 12" id="KW-0408">Iron</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 11 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 12" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="8 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="17"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="11">
        <location>
            <position position="498"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CAG5077895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="558" mass="64246" checksum="6CEC1E22EE974CAA" modified="2022-05-25" version="1">MDVVPIPTSSSYLPTGFFYPLVFIAATLAFVHFYMENMRIVKMGNKIPGPKTVPFFGNALIALGVHPKDVLNTVLQYLHHGRVIRAFLGTKLVIFIMDPHDVEIILSSNVHIDKSPEYRFFKPWLGEGLLISGGEKWRTHRKIIAPTFHLNVLKTFVPLFYENSIDLVKRLKSEVGKEFDVHDYLSAVTVDILINTAMGVRGKKRENTGFDYAMAVMDLCNIVHQRQYNIMLRIDQLFKFSKYASQQEKLLNTIHTLTGGVIKKKKQEYAEKGELAYPEEFRKISNNNTSNNTSKVEIEKINESKMRYARDDLDEIDENDVGEKRRLAFLDLLLELNRNGSTLTEEEVREEVDTIMFEGHDTTAAGSSFTLCVLGVHKDIQDRVYEELNEIFKGSDRPCTFQDTLEMKYLERVIMESLRMFPPVPAIARELKQDVKIATGGYVLPRGSTVIVPPYQIHRLEEYYPDPEVFNPDRFLPEHTQNRHYYAYVPFSAGPRSCVGRKYAMLKLKVLISTIIRNYRIHSNLTEKDFKLQLDIILKRTDGFKIEIEPRNKSTATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H6B3</accession>
    <name>A0A8J2H6B3_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS2733</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001117">
        <property type="protein sequence ID" value="CAG5078422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H6B3"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5078422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="75" mass="8622" checksum="267DD65699378F72" modified="2022-05-25" version="1" fragment="single">RAVAYRIRPLLPKHWTGFESGCILFCSAQEIQTSSNLKSLPPTVVAHDLSSLCDFKQIKRKKKKKDLFIKKNYLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H6E0</accession>
    <name>A0A8J2H6E0_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Septin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HICCMSTLAB_LOCUS2755</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001117">
        <property type="protein sequence ID" value="CAG5078484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H6E0"/>
    <dbReference type="OrthoDB" id="416553at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01850">
        <property type="entry name" value="CDC_Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000036">
        <property type="entry name" value="septin-6 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030379">
        <property type="entry name" value="G_SEPTIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016491">
        <property type="entry name" value="Septin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18884">
        <property type="entry name" value="SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00735">
        <property type="entry name" value="Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006698">
        <property type="entry name" value="Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51719">
        <property type="entry name" value="G_SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Septin-type G" evidence="6">
        <location>
            <begin position="40"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="367"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR006698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAG5078484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="419" mass="48568" checksum="A91E0EF499DB780C" modified="2022-05-25" version="1">MAAIDIERMKMETSIRNLKLSDHVGFDSLPDQLVNKSVQNGFLFNILCIGETGLGKSTLMDSLFNTNFESNPSPHNLPAVKLKSNTYELQEGNVRLKLTLVDTVGYGDQINKEDSFKAVVDYIDAQFEAYLQEELKIKRSLSTYHDSRIHVCLYFICPTGHGLKSIDLVCMKKLDTKVNIIPIIAKADTISKTELQKFKGKIMSELQNNGVHIYQFPTDDESVTAVNSSMNGLLPFAVVGSTEFVRVGNKMMRSRQYPWGTVQVENESHCDFVKLREMLIRTNMEDMREKTHCRHYELYRKKRLEQMGFSDVDHDNKPISFQQTCESMRTAHLQELQQKEDEMRQMFVARVKEKESELKDAEKELHNKFDKLKKDHMDEKKKLEESRKKLEDDISEFNRRKIQINQSHHTLTLGKSKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H726</accession>
    <name>A0A8J2H726_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS3185</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5081068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H726"/>
    <dbReference type="OrthoDB" id="6157789at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035181200" evidence="2">
        <location>
            <begin position="18"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5081068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="442" mass="49130" checksum="80616ADFD409479D" modified="2022-05-25" version="1">MLFYLFVILFASALVQTAPTESTITDLKGVIEEMTTLRPSIANETSINSTTDGSISTVMPETTTSAHTTEIEISSTTTPSTNDEISTLTPETTTESFFLSTTPNELTQDSITTTLIPEIITDAPTTETEISITTTPTTNDEIGTLTPEITTESFFLSTTPIESTTDSTTTTLIPEMITDAPTTETEISSTTTPTTNDEIISLTPETTTESFFVSTAPNELTEDSTTTTLTPEITTESFIASTTPFESITDGVFSTLTPESFPALTTPIESTTGAPISTFETINTTPNSATIGVISTSTAETPTTEETAEQNNESTDTAHIFHTRQFVLKHETPEYCNWYRINCRNYLNNQSFCTYSLVGDCNNFKAYQIWPIKQLVRPFTYIPYTFNYQYVHKEQRSYGCNLYRVKCQHCYFVNVKTEHCNHEYVEKCSNYQMIHVINSSFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H7A0</accession>
    <name>A0A8J2H7A0_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to Zan: Zonadhesin (Mus musculus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS3193</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5081100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H7A0"/>
    <dbReference type="OrthoDB" id="2095648at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00646">
        <property type="entry name" value="F-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="2"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="538"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="544"/>
            <end position="575"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5081100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="642" mass="72865" checksum="540DFE818A2597B7" modified="2022-05-25" version="1">MKHALEIFPREVWEKIFIKLSNKERFKFRYLCQTFYEAIERIITRNKLWGTLFQKNATYWKSQIIAKRFPTVRQKQWRLFFQSVFKQMFLSYQKWKLFGNSNRELDKKSCDFTKNFGDNEVITCFDVWVKILAVGTNNGSIYFYKVDRINHQPIYHTKNQNSVAQIKLWYLGPKELIAVTTSAREQLKFWNVYLKREIVTSEVYYGRNLWFVGLNRRLFVEHEYTITEYKFDLNQIHQGANCQVEIYNDPDAKFLALYSEQDKLQVLMQFGTAAVITIFQIQQNIPVFTQIDDDFFPLRPSTTRVGDDIIVDDDLICEFHISSMNVTILAHAGFLTARVIQAKDTVSVWEVCSIPLAKNEIVTCVFIFADLLLIGLNTGDINVYAIENIKSLLDTALIFKNLRVIKVGSTNKIDDNGFERTLGNPLESAGTSRNVSREIITGSPKTLKATIITDTDTIIPEDTVTPVGEPIVSALKTNSVGEIIISTIEIPQARTLEVTTEAQVFSTAITPITDDVIKILTAKTTAESLIDSTTSIKSTKDDSISTVTPDETTTSTPTTETEVSSTTTPTTNDEISTLTPEINEKSAFVLMTHNELASYGITTTSTPEKIIDAHNGGCSDQTVYFETRNTGILQLVPNQLPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H7K4</accession>
    <name>A0A8J2H7K4_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS3084</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5080710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6782661at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1471"/>
            <end position="1491"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="135"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="317"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="366"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="638"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="730"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="795"/>
            <end position="956"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="968"/>
            <end position="1009"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1062"/>
            <end position="1113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1222"/>
            <end position="1241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1276"/>
            <end position="1339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1364"/>
            <end position="1400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="180"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="285"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="322"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="413"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="438"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="519"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="541"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="795"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="850"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="866"/>
            <end position="877"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="921"/>
            <end position="936"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1075"/>
            <end position="1097"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1226"/>
            <end position="1241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1293"/>
            <end position="1323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1324"/>
            <end position="1339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1386"/>
            <end position="1400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5080710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="1510" mass="171289" checksum="141754BB34ABAF29" modified="2022-05-25" version="1">MSFLHSEHEYEPVGAGMSPKNSGPAPVVRISDTDIVPVGDSDDSIDVGGRFSPGVGLVGDVVLPLDGRIEDNAMESRELGSGDLSGAEEPETAQQLQDRLEERFFSAVTPATESRTDGEINTSQVDSSVMEELPLRRGARGLPQKIRTQAGKLRTRLKNINRRTFTLPMHDRRHKSSPKIRSDRSKSDKSKSRSSDKSSTLERASKASSTDKRTRIERIRASLPDRPRFSLDKSRFSLPDRPKFNFSQRKFHLPERPKINLPRIPSRSSFRMPSLPGRRRAPTLAEQQRQYSNESNAGSRKNIFDFSTVPRLFDRKSKARDYTTSSPKESRASSSGATESATLPRANKPKASFGSRWTQRFTDIKFADDDEDPPASIDREKPWQQAALEKPRLSLRGQESLEGSEPPAWEESEEHRKTQEFYRRQFRVSSAEREEEPELKLEERELEQEKTKQPHRHKHQEVMQKIMSRAGKIFRGDSEDSYEPPQIDPRLYGDQNIALEDSGGSKERDLYRVAFQPVDPRDYKKEHARDREKIEASLELDPGEQEEEEIDEEEELEEEEEIEVEEEIEENIEQSSELEEDVSARSDREQQASSGSSCDRRRRGVIEEIDSDEFFLRAKGISQDDMHVGRYLTSEIRDALRTSEQLPKPPQRPQRTRSMRKRESIESYDVPPTRPKRRSQESDFDPRILNNDDSFSESRHRIVYHAESAPLDLNKEEPLDDIVVVKPIRRKSRTSRSSSRVPSDPIKEFSPELPIPPAVPKRRKRHVHDKEIHFRVNGIDSCNGHDMNISVDTADEVKPRPKSEPIKPSRVPSHETISITSKVDEEEYIEPAPIPPKRHSRSRTTSIIQDDDRTSREADSIPDLGYDIEEMQLDEEMQPPGYAVIEKREKPPRPPPPRKRRKDNFATLPRSNGAPVRPIRNYSTLRPRSRTPSVGSKTPLEDDVTPYVEIESDEEHKNLLSGEVMNKMASRPLPAPPRPPRSKKDKTKVEAEFGGDLTEAYASTQTDPLPDDMVIEEEITQAKLVVAPSSSGSQIMVSMERIPSPAYFRGVTAISHERIPSPQEFYTRSSAISEPDIRGSRITPERDPEPRSLDRVPDVPPLPQAKEDNVSYLRSKSPSVTREIIPERPESRVVGLEELEERLSAFLTNETLKIASLEVADLKVDRLSVSSLEAHKIAASEIDAVVVSATEIANASEEDHTMHPSLLEELIAIKAQLEMVSNQVQESHEKDKEPHSDFSRTESTLKDFKFTIDSGVEADHLQLDSVSKTTEARAIFSTQGVERPPSPVSSSESKPKEPEKPKRAKDLEKIREKEKEKEIEIERSGSNSPVRTCVRQTASPVRSLPPVISVTPDSPDVLHPLLESSETRPQRAMISYSEIEPERPSRPSTPLTQSRPSSPQQQQFIAFTSSQIPPQFFALASPSVDEPSILDMTNQLVRALRQAGKRAMRHFVNYMVSRVSREESEAKIREIELAICALLLIIAGLIIVCFAGPRTVNHHHHWDYFNPPRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H8R1</accession>
    <name>A0A8J2H8R1_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Similar to LHFPL3: LHFPL tetraspan subfamily member 3 protein (Homo sapiens)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HICCMSTLAB_LOCUS4330</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5085281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H8R1"/>
    <dbReference type="OrthoDB" id="5873721at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007605">
        <property type="term" value="P:sensory perception of sound"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019372">
        <property type="entry name" value="LHFPL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12489">
        <property type="entry name" value="LIPOMA HMGIC FUSION PARTNER-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12489:SF1">
        <property type="entry name" value="LP10272P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10242">
        <property type="entry name" value="L_HMGIC_fpl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="24"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="99"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="126"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="177"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="256"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="280"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAG5085281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="295" mass="31866" checksum="098A8C21AAB3A1F8" modified="2022-05-25" version="1">MGSKIEYVESSHMYASNYVRNSKAIAVLWGIFTICYAIIGVVAFVTPEWIGDLEHENPGRFGLWSRCSYGSSGEVGEECIGRLDDLSTVGNVPFKASTILVGIAVVIALVSICAMLLFFFCQSTTVFYICGWMQVISAICMAVGVGVYPLGWDSPMVRAVCGASASRYVPGACAIRWAIPLAAIAALDAVTLATLAFILASRHVRLEAEPFNNGSLYKGEVNPGYVNEAQSVAGSRKSLSLRPVLLVAPPDQDRYSELSRAKSHSHHSLYSPSGPHPVHTLSTNTLSHSQRNFQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H8Z6</accession>
    <name>A0A8J2H8Z6_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Olfactory receptor 95</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HICCMSTLAB_LOCUS3526</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5082321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H8Z6"/>
    <dbReference type="OrthoDB" id="8185860at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005549">
        <property type="term" value="F:odorant binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004984">
        <property type="term" value="F:olfactory receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004117">
        <property type="entry name" value="7tm6_olfct_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21137">
        <property type="entry name" value="ODORANT RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21137:SF35">
        <property type="entry name" value="ODORANT RECEPTOR 19A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02949">
        <property type="entry name" value="7tm_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0552">Olfaction</keyword>
    <keyword evidence="8 11" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="9" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="60"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="123"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="170"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAG5082321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="370" mass="42493" checksum="7A66F657834B2C98" modified="2022-05-25" version="1" fragment="single">MNVFDEAFWRSTKMHLVASGAWPFQRPLYSILLRCMVFSFVESIMILEIIRLFYVAGDLMMTLTVIPVILYVAVIQVSVTSNHTKRLLLIVKNCWESDLLDKGEIELLRSDGRKHGDAMYTYYLLYYSQPAVYALTTLAPIILDITSPLNGTRERFFVFAEIYGVDAQEYAFYIHIHHFAALSVFTWAFVAFKANYCTLIQHACSMFTIIGRRVRILGDGLDVITSNELKLKLIKSISICLKMHQDTLDFVFQLEDNYSTFLLGVLAVNAVGMSTIGFRFITNLDDFEHNVQCLTYLAGQVFYIYYLSTFGQKLIDHSEYVFESICVCKSYNFPQEMKPMVILLMLRSLIPTKLTAGKLFIMSLENFANV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H900</accession>
    <name>A0A8J2H900_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Similar to B0563.6: Probable G-protein coupled receptor B0563.6 (Caenorhabditis elegans)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HICCMSTLAB_LOCUS4244</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5084977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H900"/>
    <dbReference type="OrthoDB" id="10033446at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053093">
        <property type="entry name" value="GPCR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47760">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR B0563.6-LIKE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47760:SF1">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="114"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="167"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="7">
        <location>
            <begin position="24"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG5084977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="214" mass="24207" checksum="D7FBB25776EFEF3E" modified="2022-05-25" version="1">MLEGSRECCLSSQGSGVTDKLLGVGVMMLLALTVERYVSVCHPGQHPRPLCGPPHLVVTLIPMVTFLVYLPNVFRGEITTCLVSFGGSLIYQKRDNSTFMHSIFYQIYKVVLEVVFKVAPIILLAGFNLRIMIVYRKSCERRRRMTLSRTMHSGDEDLRTFSEERRLILLLSSTSILFLVCVSPMVILNVTLSDSNLTLYPYQVGIIWRVLSKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H9T2</accession>
    <name>A0A8J2H9T2_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS4817</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5088374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H9T2"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5088374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="69" mass="7872" checksum="136456CF417F68A2" modified="2022-05-25" version="1">MAMILFGMPPISIRSAEPFKSYKRFTYTHTHTATTSRGELGRGGEVRGSEKFLTSSSFYAKMFLFSFNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HAE0</accession>
    <name>A0A8J2HAE0_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cc_int_1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HICCMSTLAB_LOCUS5430</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5089926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HAE0"/>
    <dbReference type="OrthoDB" id="7661671at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00397">
        <property type="entry name" value="DNA_BRE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="entry name" value="Intergrase catalytic core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050090">
        <property type="entry name" value="Tyrosine_recombinase_XerCD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30349:SF41">
        <property type="entry name" value="INTEGRASE_RECOMBINASE PROTEIN MJ0367-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30349">
        <property type="entry name" value="PHAGE INTEGRASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="DNA breaking-rejoining enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyr recombinase" evidence="3">
        <location>
            <begin position="130"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG5089926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="330" mass="38949" checksum="B8E45C36B9914991" modified="2022-05-25" version="1">MEIDEKEETVDSRSEEIPDLNLFPLKKRKVAEKYERENDKYKEFYKYTLDERLELSKVNDKIKHIICNVLKLPSVENNDKRAEFFISEMYKRRMRSSTIMRYYNQLKRVRFFEKSAIKPNQRVFDSQKPPQERVPSSSNISKMLQWCNDNKHENKRAYVILFAYYSGLRSAEICKLSVQNLDELDKRSPVLQLKCKTSECWSVPWNAVLEEFVNELVEVYADKLKNYRKTGVSESLFDMSPRVLSNTIRSFYMTAVGEVPPDGFGVHVMRYIIGTKLAQENDLAAAQYFLGHGDIQTTKRYVRYDLQQLNKKLEKVIETDEFYKGLLALL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HAH3</accession>
    <name>A0A8J2HAH3_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Poly [ADP-ribose] polymerase</fullName>
            <shortName evidence="13">PARP</shortName>
            <ecNumber evidence="13">2.4.2.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">HICCMSTLAB_LOCUS5179</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>NAD(+) + (ADP-D-ribosyl)n-acceptor = nicotinamide + (ADP-D-ribosyl)n+1-acceptor + H(+).</text>
            <dbReference type="EC" id="2.4.2.30"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the ARTD/PARP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.-" evidence="13"/>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5089293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HAH3"/>
    <dbReference type="OrthoDB" id="429950at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003950">
        <property type="term" value="F:NAD+ poly-ADP-ribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990404">
        <property type="term" value="F:NAD+-protein mono-ADP-ribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006302">
        <property type="term" value="P:double-strand break repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070212">
        <property type="term" value="P:protein poly-ADP-ribosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17747">
        <property type="entry name" value="BRCT_PARP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01437">
        <property type="entry name" value="parp_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08001">
        <property type="entry name" value="WGR_PARP1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.228.10:FF:000002">
        <property type="entry name" value="Poly [ADP-ribose] polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.228.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.142.10">
        <property type="entry name" value="Poly(ADP-ribose) polymerase, regulatory domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1740.10">
        <property type="entry name" value="Zinc finger, PARP-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050800">
        <property type="entry name" value="ARTD/PARP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012982">
        <property type="entry name" value="PARP1-like_PADR1_Zn_ribbon"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012317">
        <property type="entry name" value="Poly(ADP-ribose)pol_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004102">
        <property type="entry name" value="Poly(ADP-ribose)pol_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036616">
        <property type="entry name" value="Poly(ADP-ribose)pol_reg_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036930">
        <property type="entry name" value="WGR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008893">
        <property type="entry name" value="WGR_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001510">
        <property type="entry name" value="Znf_PARP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036957">
        <property type="entry name" value="Znf_PARP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10459">
        <property type="entry name" value="DNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10459:SF60">
        <property type="entry name" value="POLY [ADP-RIBOSE] POLYMERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00533">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00644">
        <property type="entry name" value="PARP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02877">
        <property type="entry name" value="PARP_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05406">
        <property type="entry name" value="WGR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08063">
        <property type="entry name" value="Zn_ribbon_PADR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01335">
        <property type="entry name" value="PADR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00773">
        <property type="entry name" value="WGR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01336">
        <property type="entry name" value="zf-PARP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56399">
        <property type="entry name" value="ADP-ribosylation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47587">
        <property type="entry name" value="Domain of poly(ADP-ribose) polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142921">
        <property type="entry name" value="WGR domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52007">
        <property type="entry name" value="PADR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51060">
        <property type="entry name" value="PARP_ALPHA_HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51059">
        <property type="entry name" value="PARP_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51977">
        <property type="entry name" value="WGR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50064">
        <property type="entry name" value="ZF_PARP_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0013">ADP-ribosylation</keyword>
    <keyword evidence="2 13" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 13" id="KW-0520">NAD</keyword>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PARP-type" evidence="14">
        <location>
            <begin position="27"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="PARP-type" evidence="14">
        <location>
            <begin position="101"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="15">
        <location>
            <begin position="332"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="domain" description="WGR" evidence="18">
        <location>
            <begin position="463"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="domain" description="PARP alpha-helical" evidence="17">
        <location>
            <begin position="580"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="domain" description="PARP catalytic" evidence="16">
        <location>
            <begin position="698"/>
            <end position="923"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00033987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU362114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="CAG5089293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="923" mass="105748" checksum="9BEC5A6228DD59CF" modified="2022-05-25" version="1">MSDLPYRVDYPSTTFKKREKMCHYSDCKKCILKDSLRISIVSKSLFFHPECFFKTVENPEVGDFDNFENLKWEDQKFLQEFIAKLDPDKNAESVTYRKKEFSLGYSTSNHGKCLSCEKRIEKNTVKISLSSESWKHEKIYHSYHWECFCHLPEFNLFENINEISGYNSLKPKDQQTLARPVNMKTGNLHSSEMADQSDKLFAVINSLQLLKRMDIIDLLKFNNQLIINTWNVTELKNILADRLIFGALDPCPECSGKLNFKSGLGYQCTSQFSEWCKCSAVFLDPPRSKFVVPDNIKKKHNFLKTFEPCVQRRLIKVSAPSDIVNVDGFDKKSKRPLRGMHFVIDDNLKDNKEHLVDDITKLGGLVVDEVHENVAAVISDKSNFKKNSQVIKMAKEYDIQVVSIDFIKEAKNFIDTPVSLIVDKNFSSWGGSPSKRIATTIAKSVKFEDLEDNMSSEIKKQLENFIVDECNNEKFSITLANTEIGSNLNNYFKIQVLKSPGINQPKAYLVQSWGRIGTNIGGSNLQELSLQECHDLFQQLYWAKTGNCWKNRNFNFVKKPGKMYPIETVTDKPVEVQFSIGSEKNPVTRLLMLIFNVEKMSKLLRECKIDTSKMPLGMLESKTMDKAFVILGELQTFIKNSDRLRIIERSNRFYAIIPQSFGLTSPPILDTLEKIRSMWDMTDSLKQIAIAYEMTKNSVIDDHLLNLGVHIAVLDANDKNYTVIQTYLKNTHGSTHNYRLKIEDVFKVKRSDEDSSFAKYSNYKNRRLLWHGSLSTNFAGILSQGLRIAPPEAPPNGYMFGKGVYFADIVTKSANYCRLSYNNPTGLLLLCEVALGEMYEKIDAEYITQLPKGKDSVWGLGSTYPDPGDVHVCQDGVIVPYGKPVSNDTSGFKLHYNEFVVYNVGQIRIRYIVRVRLDRYSVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HAR2</accession>
    <name>A0A8J2HAR2_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS4287</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5085150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HAR2"/>
    <dbReference type="OrthoDB" id="10462258at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="135"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5085150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="288" mass="33602" checksum="7A49646BEBCB5045" modified="2022-05-25" version="1">MKTMNKFALIKDSEGSYHVCKSKILKKDEKNNEKFILDNISVSVIYFNDDQRTLDELCKNLNLKSPSLKLIDTVRAKKPIIIEDKTLPKPRVLKFSRKEYTNGNRKQYSSSGESEYQPTDQEYTSDDQLSDDDNCNNQTQITTDNQDTRCKSKRRVTQPITRKTWTKEEEKDFNYHFEHYLKTKTLPGLLVVRSIQSEFGVLKNRTPEVINAHVFNKNQKAKSATNFDDKKSDKTHSHENRIQKHLKYIFQDCIEKKKVPALDACAIAKRTDKLLCKLSDTNIQRRIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HBN0</accession>
    <name>A0A8J2HBN0_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Acetyl-coenzyme A synthetase</fullName>
            <ecNumber evidence="5">6.2.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HICCMSTLAB_LOCUS4169</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>acetate + ATP + CoA = acetyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:23176"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.2.1.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.1" evidence="5"/>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5084667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HBN0"/>
    <dbReference type="OrthoDB" id="1706066at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003987">
        <property type="term" value="F:acetate-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016208">
        <property type="term" value="F:AMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019427">
        <property type="term" value="P:acetyl-CoA biosynthetic process from acetate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05966">
        <property type="entry name" value="ACS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.30:FF:000004">
        <property type="entry name" value="Acetyl-coenzyme A synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12780:FF:000001">
        <property type="entry name" value="Acetyl-coenzyme A synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011904">
        <property type="entry name" value="Ac_CoA_lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032387">
        <property type="entry name" value="ACAS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02188">
        <property type="entry name" value="Ac_CoA_lig_AcsA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001208">
        <property type="entry name" value="PRK00174.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24095">
        <property type="entry name" value="ACETYL-COENZYME A SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24095:SF244">
        <property type="entry name" value="ACETYL-COENZYME A SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16177">
        <property type="entry name" value="ACAS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 5" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acetyl-coenzyme A synthetase N-terminal" evidence="9">
        <location>
            <begin position="24"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="7">
        <location>
            <begin position="94"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="8">
        <location>
            <begin position="562"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="234"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="235"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF16177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAG5084667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="678" mass="76198" checksum="AA0339163A1BC9F6" modified="2022-05-25" version="1">MADRIYYPNAELAKTAYCNSMDQYKKMHEKSIKQPEEFWSEIAKQFYWETTSSNDKFFSYNFNRNEGDIFIKWMEGASTNISFNLLDKNVKCGNGDKIAFYWEGNDIEDYSRLTYRKLLEETCKFANVLKSKGVQKGDRVAIYMPMILELPIAMLACTRIGAVHSFAGYSSDSLAERVLDSKAKVLLTADGAWRGSKLLHLKAICDQAMDKVKSHGHNVESCIVISHLRRVTCPPGNTSDGGKTKNATSNGSSSDVNLSWDDDRDCWWHEEMEDADSSCYPVWVAAEDPLFILYTSGSTGKPKGVLHTTAGYLIYAATTFKYVFDYKPNDVYWCTADIGWITGHTYVVYGPLANGATSVLFEGTPFYPLNDRYWSVIDKYKVSQFYTAPTAIRSLMKFGDDLVKKYDLDSLKVLGSVGEPINSEAWLWFYNLIGHGKCSIVDTFWQTETGGHVVTPLPGATPMKPGSASFPFFGVLPELLDEDGKIIEGEGEGYLVFRQPWPGMMRSLYGNHERFQTTYFDKFNGFYCTGDGARRDSDGYFWVTGRIDDMLNVSGHLMSTAEVESVLAEHGAVAEAAVVSKPHPVKGQCLYCFITPNEGKNFDKQLQDELKKKIRERIGPFAQPDIIHHAPGLPKTRSGKIMRRILRKIAVGDRNVGDTSTLADEGIVDLLFQLRPEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HC42</accession>
    <name>A0A8J2HC42_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Similar to Cnot6l: CCR4-NOT transcription complex subunit 6-like (Mus musculus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HICCMSTLAB_LOCUS4664</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5087972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HC42"/>
    <dbReference type="OrthoDB" id="1394818at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000343">
        <property type="entry name" value="CCR4-NOT transcription complex subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050216">
        <property type="entry name" value="LRR_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055414">
        <property type="entry name" value="LRR_R13L4/SHOC2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051:SF54">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23598">
        <property type="entry name" value="LRR_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00019">
        <property type="entry name" value="LEURICHRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Disease resistance R13L4/SHOC-2-like LRR" evidence="4">
        <location>
            <begin position="58"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF23598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAG5087972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="180" mass="20508" checksum="385A59B3272A0C8E" modified="2022-05-25" version="1">METHVSKSNKMSRNHKDKYESSSSRRAHSIMSTEEANSGKKSHWPELEITGNVKNLSPNLWQLKHLTALYLNDNSLQRIPIEIGRLSNLKVLDLSNNKLRSLPSELGDLINLKELLLNQNYLRVLPYELGKLFQLQVLGLHGNPLSKEMMALYGEPQGTHKLLSFMLDNLQEIFLSTSAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HCF1</accession>
    <name>A0A8J2HCF1_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Similar to ceh-19: Homeobox protein ceh-19 (Caenorhabditis elegans)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HICCMSTLAB_LOCUS4789</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5088289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HCF1"/>
    <dbReference type="OrthoDB" id="6159439at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020479">
        <property type="entry name" value="HD_metazoa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050848">
        <property type="entry name" value="Homeobox_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24333">
        <property type="entry name" value="HOMEO BOX HB9 LIKE A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24333:SF9">
        <property type="entry name" value="HOMEOBOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00024">
        <property type="entry name" value="HOMEOBOX"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 5 6" id="KW-0371">Homeobox</keyword>
    <keyword evidence="4 5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="8">
        <location>
            <begin position="155"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="5">
        <location>
            <begin position="157"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="140"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAG5088289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="275" mass="31320" checksum="DFAC7EB7AC89CCCB" modified="2022-05-25" version="1">MKEDLDMSSQFSEYPGYCDSSDESVITDQRSDPRAVSSPISSAFSIDSILGKKDHRKNESEVEFNDKSDKSYQEFKEQAHVIRPLAISSNPANYFYEHGANESYPAFEGLGDPGYSASLASASFIYTNWFSQNKTNPLFGLQAPKPSGRRSRKPGIDRKPRQAYSAKQLERLEAEFKVDKYLSVSKRMELSKTLSLTEVQIKTWFQNRRTKWKKQLTSRLKIAQRQGTFPPAYLTPTQYPLLPYYVSPLIFNSSSSDEIMSSSIVVNQPISEERL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HET7</accession>
    <name>A0A8J2HET7_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS6710</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5093269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HET7"/>
    <dbReference type="OrthoDB" id="10375597at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="149"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="166"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="230"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5093269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="311" mass="35427" checksum="68A15A8C90CA4B33" modified="2022-05-25" version="1">MDLYCLLTDLNQSKYCIVPTQNVFELNEKNNLKRIRSDTYQADKKYYVTGASLQIGIGGFYIIDSHDDYKVLRKRNPVDSRIILAKLPDYSPLAESQVSKKAGTSKISNSEQVVKNPDVPRKSTKKSTVAIARKDNELNSADYYMEQEIATGSGNTRETGIREVTEGTEETEETEGTEVLEETEEGTSKDNNSELPEIAEETRMAAPGNRDNRRNNDSDSESDDFDNNKENPSISKKSRSVSRTFQTPRPRTKQFIQRPFSRVQQLKRLQKKNKNKNNNSLQSPRRKCRSNPRIPTFTEIITVENNVEVSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HFF7</accession>
    <name>A0A8J2HFF7_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HICCMSTLAB_LOCUS7096</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DEAD box helicase family. DEAH subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5093770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HFF7"/>
    <dbReference type="OrthoDB" id="10253254at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd17980">
        <property type="entry name" value="DEXHc_DHX35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18791">
        <property type="entry name" value="SF2_C_RHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000578">
        <property type="entry name" value="probable ATP-dependent RNA helicase DHX35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011709">
        <property type="entry name" value="DEAD-box_helicase_OB_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048333">
        <property type="entry name" value="HA2_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF136">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DHX35-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21010">
        <property type="entry name" value="HA2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07717">
        <property type="entry name" value="OB_NTP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04408">
        <property type="entry name" value="WHD_HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 10" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="8">
        <location>
            <begin position="57"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="9">
        <location>
            <begin position="253"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAG5093770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="646" mass="72949" checksum="5C298F972EDF6C37" modified="2022-05-25" version="1">MTSKLKFIAPGDSSWHEDKPDIDEHSSTQFIYNANHSLALDLQRKRLPIFKNRSHIVYLLENYQTLVLIGETGCGKSTQIPQYLVEAGWCTDGKIICITEPRRVAATSLANRVADERGCILGTEVGYSIRFDDCTDETTKIKYMTEGILLREMMSDPLLTKYCIIILDEVHERTLLTDIIMGLLKKIIRKRKDLKVIVSSATVDAEELRDYFNISTSKDPKDSTSTILSVEGRLYPVDIFYVKEPVPDYVKAVVDSALKIHSNEESGDILAFLTGMDEVDRAVSLLKEHAELIKEGKQKLMPLPMYGSLPNADQLKVFWKAPNNTRKVVIATNIAETSITIPNIVYIIDSGFAKIPLYTENAYDEFIESNPPQMQRSDLAPAILQLKALGIDNVLRFNFPSVPPSKSLVAGLELLYALGAIDKDGSLTKPLGLTMAEMPLEPVFAKCLYASGEMGCSDEISTILSMFQVQNILIRPSSGQASIRARIAHRKFEVEEGDLITMLNIYTAYEKNKSASWCQKYFLNFKGLKRATEIRSKMRIMMKNLNIPLRSSNGDLQLILRCLTAGLFPNAAFLHYTGVYKTVRGDRDLYIHPNSCLYTVQQPQWVLFCEILQTTKLYMRELTVIKSEWLLELAPHFYERTALNSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HFH4</accession>
    <name>A0A8J2HFH4_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Similar to PTGER4: Prostaglandin E2 receptor EP4 subtype (Homo sapiens)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">HICCMSTLAB_LOCUS7126</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5093800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HFH4"/>
    <dbReference type="OrthoDB" id="5959154at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007189">
        <property type="term" value="P:adenylate cyclase-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007204">
        <property type="term" value="P:positive regulation of cytosolic calcium ion concentration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008365">
        <property type="entry name" value="Prostanoid_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11866">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR FAMILY 1 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11866:SF16">
        <property type="entry name" value="PROSTAGLANDIN E2 RECEPTOR EP4 SUBTYPE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 11" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 11 14" id="KW-0675">Receptor</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 11" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 11 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="40"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="83"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="113"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="152"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="198"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="269"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="310"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="13">
        <location>
            <begin position="52"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CAG5093800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="397" mass="45313" checksum="E3229EBF5117844E" modified="2022-05-25" version="1">MTSTLESWNNSLLTLDSNLTTMITFTDVTTPKKLTAVQQIILTLVFMFGIVGNISALIILFYKDKRRNHKHLLMLRCLAFNDLIALLGQLVQMYVATYAPLIATQKYFCALRILWRTFGLFSGGVAIVMAVERWLALARPFVYQKHVTYPRIVHFMIIFWIAALTVTSLPLFGFGLYYDNGQCVRYREAKMPVDIAYAYLSFSFGTCLCFSIVWFNLAVAKVLGKFRQKNKLLRRCSRAASHNKAFSSSKTFTLGEVGSTCEERAFARLMTVLSTSFVICWMPHMITIPVAQYYLSLKETTTVIKKSIKIFFQIADVLLGVHFTLDPYFYVLLRMPKNKFSLLKHLCRICWPARSRSSSSNHHDHSGEDPPTPITEVPLTSIIAEHQDLLHLNTLPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HG96</accession>
    <name>A0A8J2HG96_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Similar to tmem145: Transmembrane protein 145 (Xenopus laevis)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HICCMSTLAB_LOCUS8096</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5096211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HG96"/>
    <dbReference type="OrthoDB" id="205745at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007186">
        <property type="term" value="P:G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019236">
        <property type="term" value="P:response to pheromone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053880">
        <property type="entry name" value="GPR180-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047831">
        <property type="entry name" value="GPR180/TMEM145"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019336">
        <property type="entry name" value="GPR180/TMEM145_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23252">
        <property type="entry name" value="INTIMAL THICKNESS RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23252:SF24">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 145"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10192">
        <property type="entry name" value="GPR180-TMEM145_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21892">
        <property type="entry name" value="TMEM145_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="2 6 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035308754" evidence="7">
        <location>
            <begin position="22"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="179"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="214"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="256"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="288"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="328"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="358"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="392"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="domain" description="GPR180-like N-terminal" evidence="9">
        <location>
            <begin position="25"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="GPR180/TMEM145 transmembrane" evidence="8">
        <location>
            <begin position="192"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF10192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF21892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAG5096211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="464" mass="53044" checksum="D2B3E8328721E0BA" modified="2022-05-25" version="1">MNVIISSIVLLLIFSTSNVKSKILRGELVTNQNWAFLARFCFLTEKGKFRYDFVVKENSNETSNVNLLLYYDAPNQWPSVYPSDKTCEQKKSILSLDHGQIVPLSASLARISGCEQLDDPWAKLHCTSYREFRSSRPRWWFIVLADCSSKSGLNVSYDMSLTNGESGSFWREHFSADEFWLLPLLIGAESAYILLVSYSLYVSFQLRERRLLHVTYKLFMISLIYQLIGISLEIYSLAYRGATGFESRRAELFGNLFESCAETLFTLLILLLALGYTVTKSVLSNKQLWCLIWFIGTIVFLQLVLFIYEAEVFDPGLVLYIYESPPGFGLMALKVLAWGVFVACCYRTSRKSSSKFHFYASLLSLGSAWFLCHPLTVLAITFAVDKWVRQSVVKGCSLWIIFVGHAMFLYVTRPTSSNERFPFHIRTWQVVPIAVGQNNNYEPRRGGTAAIFTINLNRNRARPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HGA6</accession>
    <name>A0A8J2HGA6_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Protein DIS3 homolog</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Ribosomal RNA-processing protein 44</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">HICCMSTLAB_LOCUS7102</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
            <location evidence="3">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 16">Belongs to the RNR ribonuclease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5093776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HGA6"/>
    <dbReference type="OrthoDB" id="372421at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000177">
        <property type="term" value="C:cytoplasmic exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071034">
        <property type="term" value="P:CUT catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071031">
        <property type="term" value="P:nuclear mRNA surveillance of mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016075">
        <property type="term" value="P:rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09862">
        <property type="entry name" value="PIN_Rrp44-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1010:FF:000010">
        <property type="entry name" value="Exosome complex exonuclease DIS3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.700:FF:000001">
        <property type="entry name" value="Exosome complex exonuclease exoribonuclease (Rrp44)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000125">
        <property type="entry name" value="exosome complex exonuclease RRP44 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.690">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.700">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041505">
        <property type="entry name" value="Dis3_CSD2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001900">
        <property type="entry name" value="RNase_II/R"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022966">
        <property type="entry name" value="RNase_II/R_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050180">
        <property type="entry name" value="RNR_Ribonuclease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033770">
        <property type="entry name" value="RRP44_S1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23355:SF35">
        <property type="entry name" value="EXOSOME COMPLEX EXONUCLEASE RRP44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23355">
        <property type="entry name" value="RIBONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17849">
        <property type="entry name" value="OB_Dis3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13638">
        <property type="entry name" value="PIN_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00773">
        <property type="entry name" value="RNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17215">
        <property type="entry name" value="Rrp44_S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00670">
        <property type="entry name" value="PINc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00955">
        <property type="entry name" value="RNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01175">
        <property type="entry name" value="RIBONUCLEASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="11 20" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="10" id="KW-0271">Exosome</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0540">Nuclease</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="PIN" evidence="18">
        <location>
            <begin position="64"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="domain" description="RNB" evidence="19">
        <location>
            <begin position="445"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="855"/>
            <end position="888"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="17">
        <location>
            <begin position="875"/>
            <end position="888"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00077221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00077930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU003901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="SMART" id="SM00670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="SMART" id="SM00955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="CAG5093776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="888" mass="101236" checksum="57039DCA149B2787" modified="2022-05-25" version="1">MLATKTFFRKTKSGNIFKIVRDHYLRDDIWCGSEACESCKPRKKDLVLEEKNPGTKSSLISDPYYLLLDTNIVLDQINILEEDLLCNVIILQTVLEEVKHRSSNVYKKLKDIIADPKRKFYVFVNEHHKDTFVERVPGEKINDRNDRAIRTACLWYKSHLEQSKNNNINIVLLTDDNENRSKAQVEGCLAFTMEEYVCSLENSGFLEDKLCKKNYEIDGGKGEPLFPSHLTPAQLHDGIKNGKLLQGTFLASRENFLEGSVNVEGMEKFVSVELLPEEEWSVPSELVLQDEADEEDPGDILEEEKEIIVKTTTEVERTPTGKIVGIIRRKWRQYCGILQPSAVKGNVKHLFVPAERKIPKVRIETRQSETLSSQRIIVAIDSWPRNSRYPSGHFVRALGKVGDKETENEVLLLEHDVTHSRFSDAVLSFLPKLPWIITEEDIASREDLRHLDICSVDPPGCTDIDDALHCRDLENGNLEVGVHIADVTHFIRPGTALDQEAALRATTVYLVDKRIDMVPGLLSSNLCSLRGNEERFAFSCIWEIDHDANIINTRFLDSETHDPIEVEAKKLRDTNSMVEEFMLLANISVAEKILAEFPDCAMLRRHPEPPQSNFEPLIKAGRHQGFEINTSSGKELAQSLESAHKDDNPYFNTMLKILATRCMIQAVYFISGMVQQSEFFHYGLACPIYTHFTSPIRRYADIVVHRLLAVCIGADATYPDLLDKKKNHALCHNLNYRNRMAQYAGRASVALNTHLFFREKIEDEDGYILFVRKNALQVLIPKYGLEGTLYLNKKGDTSGVKFTYNEEEHTQTCGDVVFRSFDPVIVQLSLDRSNVQHEKLVFKLVKPEISGFSVPGVKKRKVSDPEPIPIEVPAKKNKKQKKKKKNKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HGW8</accession>
    <name>A0A8J2HGW8_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Similar to Fibp: Acidic fibroblast growth factor intracellular-binding protein (Mus musculus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS9822</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5100749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HGW8"/>
    <dbReference type="OrthoDB" id="16955at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008614">
        <property type="entry name" value="FIBP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13223">
        <property type="entry name" value="ACIDIC FIBROBLAST GROWTH FACTOR INTRACELLULAR BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13223:SF2">
        <property type="entry name" value="ACIDIC FIBROBLAST GROWTH FACTOR INTRACELLULAR-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05427">
        <property type="entry name" value="FIBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5100749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="358" mass="42165" checksum="9D0FAC15853AB708" modified="2022-05-25" version="1">MLSDVDVFISNYTLVDPEVYQLWVDGYSSSDAVSLLNQRGICQQTNAPIELVASDILDHYRTYSLLERLIHTPTKLASEQLAFQIEPQTSQMLIEMYYEFDDCVIREILGKKLTSKSRKDLDEVAEKTGITLKSCRRQYDNVKRVFKAVEDLSGSLVTNIKQHFLLPDDLAKRYAAVVFIACLRFEMSKRKLQFLTFPDLYHCANIMMSSWTYRYTGSEYFDTDLDREFLVELSECRVLLENDKHHKYLVCIKLKPTLLEKMFQELDLNFRNYSRALLGIGCNLHRSRELRFFFLELVERCIEPWRQVNWSHTDLKNFLNAYTQCALDMDVLREGTLRDAFERYMKVVTSCLLRMYHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HHF8</accession>
    <name>A0A8J2HHF8_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">GATOR complex protein NPRL3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Nitrogen permease regulator 3-like protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HICCMSTLAB_LOCUS7721</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="2">As a component of the GATOR1 complex functions as an inhibitor of the amino acid-sensing branch of the TORC1 pathway.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Lysosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the NPR3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5095463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HHF8"/>
    <dbReference type="OrthoDB" id="18648at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990130">
        <property type="term" value="C:GATOR1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034198">
        <property type="term" value="P:cellular response to amino acid starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904262">
        <property type="term" value="P:negative regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010508">
        <property type="term" value="P:positive regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038202">
        <property type="term" value="P:TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056603">
        <property type="entry name" value="HTH_NPRL3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005365">
        <property type="entry name" value="Npr3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13153">
        <property type="entry name" value="CGTHBA PROTEIN -14 GENE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13153:SF5">
        <property type="entry name" value="GATOR COMPLEX PROTEIN NPRL3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24064">
        <property type="entry name" value="HTH_NPRL3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03666">
        <property type="entry name" value="NPR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0458">Lysosome</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="GATOR1 complex protein NPRL3 C-terminal HTH" evidence="4">
        <location>
            <begin position="480"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="415"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="415"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="425"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU368069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF24064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAG5095463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="545" mass="62338" checksum="E00F8BED298BF499" modified="2022-05-25" version="1">MEINPLSIILVKRDSKGDRMLFRYPHMDNNKRDSNQCTKRKNPYSLIIAEDSLQSLPCPTSNITNGNLSGLSDEVLSTLFAVKPELCEMKFELKLNNVRFVGHPTLIPSSRGKEVNSSMLFNVVFALQAQANQSVVKCYHDLSKRLGITLRHEEKRCGFLTEEIKMMVSTLDEIATRSEEESEGEESPYELILKKSLLAKDLKSAFDSLCNTGIVNLMINKWTLVNFCLPQKVHQIHKKGFIMNPEMIDRCLNSLRPYHGLLLLIEPVDLLESLPTDASPALRRMIQMYNPLKSLQTLAADTDLSLAQIFQLTGHLVYWAKATVIYPLCESNVYVISPDAVISNQLMESFIDQFPGLNLLQILSEFSLPTSISEKLNPLGQPQQQQQIVKIIVWLLKNRLLLQLHTYVQFMPTDHGRDSAETRNQDGLSPNRATESDSSWSYNNTPKGISSEMRIDRSISMSKEEEIFEYRSENFPISSEDIMLLDKLCGLNYFDGRHHLEEIMYLENIRRSQLLEILEKFRNILIISKHEDPAITLFYSQHGFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HI11</accession>
    <name>A0A8J2HI11_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Similar to OTOF: Otoferlin (Homo sapiens)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HICCMSTLAB_LOCUS10731</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5101870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HI11"/>
    <dbReference type="OrthoDB" id="10059618at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007009">
        <property type="term" value="P:plasma membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04017">
        <property type="entry name" value="C2D_Ferlin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037723">
        <property type="entry name" value="C2D_Ferlin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012968">
        <property type="entry name" value="FerIin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037721">
        <property type="entry name" value="Ferlin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012561">
        <property type="entry name" value="Ferlin_B-domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12546">
        <property type="entry name" value="FER-1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12546:SF60">
        <property type="entry name" value="MISFIRE, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08150">
        <property type="entry name" value="FerB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08151">
        <property type="entry name" value="FerI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01201">
        <property type="entry name" value="FerB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01202">
        <property type="entry name" value="FerI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="C2" evidence="6">
        <location>
            <begin position="1"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="6">
        <location>
            <begin position="149"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="6">
        <location>
            <begin position="664"/>
            <end position="789"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAG5101870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="1082" mass="124064" checksum="264E0DDCA7D2EA0D" modified="2022-05-25" version="1">MGRRRKGKHGTYQVAVTIIEAKYLAQNSNPMVVVKVGHQKKKTIIRNRTDSPYYNEYFIFNYTGDFDTFLHTRISISVYLKRCMRLKFHGGIFFEVSTVWDQPDHEYYHKWAMLTNPKDPTGSPKGYVKCNIGINAKGATIPTHLETDNEEDIEGNLLMPIANFCATGRQKAHYIFTVFRADGLPCKNTSHCCGNSDNIVNPFIQISFAGMKGETSCHTESYTPRFNEKIIFTEMFPPLSYRARIALKDKIDSCRSKTLATFTLNLAKLSNSGEYGFLPTYGPSFIQFYNGTSEGSECSCVSKCVSNTRPIYQGRVLLFLKTEIDDSEAPIFTGVDFEPTAPIIEAKYLLVGIVYGANMIDRSRFMRKPISFEITIGNVGSNIFPSKMETYDQLSKQVILDKRPAFVSSTAPRLTATTDGKFNYLPLGSNKPCMYVKSWWPNLEWRVSNTNSLSYIANFLEDMLSELETLIAVENATAYETYNSVIESLKRYCMEYLSILDTDIYYENGGTTKLDRHRINLCHYCIQDIITMINVNGKLLNNNYIKIAMLHAYKYLTSIRQISEDPQHSFPDVFIWMIAGSKYVALARLPTSEIIFAEDEMSRGTKCGQRINLFMKDITDGFVDDSVDYSACNIEIFLWFGNAKFASACWSAIPHGYDVEHSVNMELFPKSLNYTTSSKFQLRAHIFQGRFDSGLDATGLMDPFIRIIFHGYTVTTRTIKQSLAPVWDETLVFPGIDLYGMRESIKSMPPQVIIEAFDWDFCGPKEFFGRCIAVPVVKFKEETYSPPEFPPTLIWYKLETQSDFQGSVLAAFELIEIGGDTDILLTPSKESITYNLPHDIRPVMISHRLEVIFWGIRNMKKINFARVNRPRVVVECSGVQVNKDQTEHEEENYEADEDESYDWWSKYFASLEEERHRELGENKILPPGQKPIATFRIYSMELEMQPEFERFQEKLTTFELSRGKDTGCNEQDKKNISAICLFECPFPRPQVPSWEWLSVEDLALRQGHISIYPWSFLDKTKYKTKSGRDVSYGFLSDYPPQEPVKLIVRLYVIRAINLHPCDPLTGKSDPYLIMKLGKNHEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HI64</accession>
    <name>A0A8J2HI64_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similar to Sec3: Exocyst complex component 1 (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS5901</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5092082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HI64"/>
    <dbReference type="OrthoDB" id="27109at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000145">
        <property type="term" value="C:exocyst"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005546">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006893">
        <property type="term" value="P:Golgi to plasma membrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048628">
        <property type="entry name" value="Sec3_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16092:SF14">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 1 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16092">
        <property type="entry name" value="SEC3/SYNTAXIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20654">
        <property type="entry name" value="Sec3_C-term"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exocyst complex component Sec3 C-terminal" evidence="1">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5092082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="124" mass="14140" checksum="F5AF76FAF12B1E67" modified="2022-05-25" version="1">MYLLVRLSQHVMSAQDTGSFLSMTFASALVQVKRSFDKFMQLQQQSILKDTKVNRRNKCGILPYVANFGSFARITDKIFKNSDRKVDLEKSYTKLVATIPVMKQLNGPAVVPKRSFRCFFGALH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HI68</accession>
    <name>A0A8J2HI68_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Similar to CG7650: Phosducin-like protein (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HICCMSTLAB_LOCUS8236</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the phosducin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5096491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HI68"/>
    <dbReference type="OrthoDB" id="70588at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008277">
        <property type="term" value="P:regulation of G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02987">
        <property type="entry name" value="Phd_like_Phd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.168.10">
        <property type="entry name" value="Phosducin, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001200">
        <property type="entry name" value="Phosducin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051499">
        <property type="entry name" value="Phosducin-like_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023196">
        <property type="entry name" value="Phosducin_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024253">
        <property type="entry name" value="Phosducin_thioredoxin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46052">
        <property type="entry name" value="PHOSDUCIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46052:SF1">
        <property type="entry name" value="PHOSDUCIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02114">
        <property type="entry name" value="Phosducin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00677">
        <property type="entry name" value="PHOSDUCIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosducin" evidence="4">
        <location>
            <begin position="49"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="15"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="20"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="43"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAG5096491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="283" mass="31845" checksum="0E4605D98C106344" modified="2022-05-25" version="1">MATLEDKILGEKLEYYCSSSEDEEKDSGDSDSEESKSELKGSVQSEEIPSSSYDEWNGTSSNTGPKGVLKDWQRFKQLESEKRADQERERLQLIKKLSITCRSALDDEKEKLSETDPELAELLEDDFLLEYQKQRMKEMLVKANKFQFGTLINLSSADEFLDAIDKEDKSVTVVVHIYERNIPACEAMNGSLITLAQEYTNIKFCKILGSTAGLSKHFKKRGVPALLVYKNGQVIGNFVNVSDTLGTDFYASDVENFLLENGIIVDKNNISKIIADSINDDSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HI74</accession>
    <name>A0A8J2HI74_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Sodium/nucleoside cotransporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HICCMSTLAB_LOCUS5916</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5092100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HI74"/>
    <dbReference type="OrthoDB" id="6075923at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005415">
        <property type="term" value="F:nucleoside:sodium symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008276">
        <property type="entry name" value="C_nuclsd_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018270">
        <property type="entry name" value="C_nuclsd_transpt_met_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011657">
        <property type="entry name" value="CNT_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002668">
        <property type="entry name" value="CNT_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011642">
        <property type="entry name" value="Gate_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00804">
        <property type="entry name" value="nupC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10590">
        <property type="entry name" value="SODIUM/NUCLEOSIDE COTRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10590:SF4">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 28 MEMBER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07670">
        <property type="entry name" value="Gate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07662">
        <property type="entry name" value="Nucleos_tra2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01773">
        <property type="entry name" value="Nucleos_tra2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="66"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="106"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="160"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="184"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="213"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="268"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="348"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="373"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="424"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="domain" description="Concentrative nucleoside transporter N-terminal" evidence="8">
        <location>
            <begin position="189"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleoside transporter/FeoB GTPase Gate" evidence="10">
        <location>
            <begin position="271"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="domain" description="Concentrative nucleoside transporter C-terminal" evidence="9">
        <location>
            <begin position="373"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="579"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF07662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF07670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAG5092100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="579" mass="64381" checksum="670A0B9CA113A374" modified="2022-05-25" version="1" fragment="single">MAGIASPAFSEVERKISEHNLRISIDLTKENNGEEQKKYIESIDSENSQSLKKETKFQLCFSNKNALIKYFGVIAINIVVLIYLIFASLYWSKNNNNCVFEWCDGYGMLLLLISITYLSLCYYFIIKKYFSNAIKLIFRPCCDCLESINRIRYASCSIKALFYLIILASVIVFLIYDTIGSRDRLISCIGMFVMLSFGLLFSKHPRKINWRPVIWGLILQFGFGILTIRWSVGRMIFQCLSNKVAKFLNYAESGSKFVFSDQLVDSKVFAFSALPVIFFFSFMIQILYYLGAMQWVILKLGWALHAVMSTTVCESLNAAANTFLGMTESPLLIKPYINKLTTSEIHSVMTSGFASVSGTVLAAYISFGAQPAHLITASVMAAPASLAFSKLFYPETEKSQTTFKNIPLQKSEDTSVMDAATKGALAGIPLVLGIIANIVAFVSFISFFNAILSWFGGLVGFTDLTFEYLLSRAFMPLSWIIGVPWDQCEDVATLIGLKTVVNEFVAYQKLGEFKKLGKLTPRVEGIATFAICGFANPGSVGIMMGGLGQLAPDKREQIAARKLLPSPRCNLSNVLAPLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HIG4</accession>
    <name>A0A8J2HIG4_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS9722</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5100649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HIG4"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="164"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="170"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="194"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5100649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="247" mass="28755" checksum="22773214CA74BB05" modified="2022-05-25" version="1">MKAKKEREEMERAKSSSEKKEKEEPKEEDPNKIETVADIHEQKRDESPEKLENTREIDETQEKKMKENMKENNNKNGVEEKTEVEEKPTLGTKPKIIGNVAVKPLIKESFANHLVMVNKQTNAMLAFATAMERTTDKLNDLMKESMKMVQMLCNFTDKELETKRDRANKSEVTPISVHSSQKRPLENAETGNENGKKAKFDEGQESRVNKELELMRKSIEEKELSATMNIKRDYKLTQKVNFNIWYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HIH8</accession>
    <name>A0A8J2HIH8_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Midasin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HICCMSTLAB_LOCUS9537</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the midasin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5100405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="422220at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000055">
        <property type="term" value="P:ribosomal large subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000142">
        <property type="entry name" value="Midasin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000582">
        <property type="entry name" value="Midasin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000764">
        <property type="entry name" value="Midasin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:004102">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040848">
        <property type="entry name" value="AAA_lid_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011704">
        <property type="entry name" value="ATPase_dyneun-rel_AAA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048617">
        <property type="entry name" value="MDN1_AAA_lid_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041190">
        <property type="entry name" value="Midasin_AAA_lid_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48103:SF2">
        <property type="entry name" value="MIDASIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48103">
        <property type="entry name" value="MIDASIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07728">
        <property type="entry name" value="AAA_5"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17865">
        <property type="entry name" value="AAA_lid_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17867">
        <property type="entry name" value="AAA_lid_7"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21108">
        <property type="entry name" value="MDN1_4th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="9">
        <location>
            <begin position="285"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="9">
        <location>
            <begin position="616"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="9">
        <location>
            <begin position="1044"/>
            <end position="1189"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="9">
        <location>
            <begin position="1368"/>
            <end position="1528"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="9">
        <location>
            <begin position="1709"/>
            <end position="1891"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="2069"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAG5100405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="2069" mass="233133" checksum="318809DBF991E039" modified="2022-05-25" version="1" fragment="single">YSKNSSIHSLKELFSKYINKEDLNENDCKEVIAKLSCHVLMDQNHVQSVAEFFPQYLILLLSHAIPIECNELNAESNPQLHRLNCVILGKLISINPDVLGFTLRYFEVYPEPFATAVESTPAKKFKSHHVSCKVQDVSDYDIVVATYNILCVASNHFKHKWNWSVFYNFLSEDNDQLKWIALKCIGIVLNMSESTKMACAKILIPNFHQFLINHNTHDNNIVQLLTTDDSNLQELEKTVADSDSLVSIAGVLLPVFDKANRVQSSLVPVPSMESNLQSLALAVASRKCVCLQGPVGCGKTALVEYLAKVTGRGPSDFIKVQLGEQTDSKMLLGTYRCTDIPGEFVWQPGVLTQAVVSGKWLLLEDIDSAALDVISVLSNLMETGTLSVPGYRDTIHTKSGFQLFVTQRLISSASGLFRQSANATNLLGKHWLCVHMDPLTKDELITVVKTLFPVLTTTATKIIDVFLLFSMGDHGAEDETEEKLSTAGRLISTRDLIKWCTRSIVNFNVSQEYTARKLLLDAVDIFCCSVPDTKKRLDLAIAVGHILGIVKTETESMMNTRTIEVSNDDKVFTVGRAVINRNTNRSVQNDKTKDNFTIKSRPSAVLLERVACCIMQNEPVLLVGETGTGKTSSIQYLAKKAGHKLIVINMNQQSESADLLGGYKPVDLKHLIKPIREEFEVLFRAYFAVIPNKKFLDYLGTAYTEGNWKTLITLMSHSATAALKRLRGDIDKIKTGTKRKSDDGNVQKQLETNKKKLVQWEKINMKLDKLKSQLKTELSLAFAFIEGSLIKALQEGYWVLLDEINLASSETLECLSGLLEGSTGSLSLFERGDKESIKRHKDFKIFACMNPATDVGKKELPIGLRNRFTEFYVDELTEKSDLQALVISYLEGLNLEPTILNNIVKFYLQVRKDAVNKLYDGTGHTPHYSLRTLCRALSVTVSFKSGCALRSLYESFCLSFLTQLDSVSYKLVEQLIKNMIHTKSWKETLKTPIPNPSTKNNVFIKFEPYWVPRGTLDPKKPKDYIITESIKQNLRDLARVVAISRMPVLIQGNTSVGKTSLIKYLAKASGHVCVRINNHEHTDLQEYVGNYVANETGKLVFKEGVLVEAMRKGYWIILDELNLAPSDVLEALNRVLDDNRELFIPETQESIKAHNNFMLFATQNPPGVYGGRKVLSRAFRNRFVELHFDEIPSTDLEIILENKCNVPTKYCKIMINVMKDLQLRRKNTAAFMGKHGFITLRDLFRWGDRYKAKEVNKVFDKKTKTITNQSENYDWQQLLADEGYLVLASKVRQPDEAKEIIEVLKKHFKCVVDPENLFTLHEKTSPETRSILETLESIERSPMPGFEHIVWTYQMRRMAVLVIKSCQFKEPILLVGETGGGKTTVCQLAAVLRAKNLYSVNCHMNTESSDFLGNLRPVREHTEDNQRLFEWVDGPLISAMRNGDLFLADEISLADDSVLERMNSLLEPERTLLLAEKNNDSIDKNQADCGITAHEDFCFIGTMNPGGDYGKKELSPALRNRFTEIWCEGCVSDNDLRNIIEYNLRPEEIKNENQDIATSILAFINYFKSSGIGKKFVVSVRDILTWVNFIKFCRNASNSKLTSSVAFIEGARLTYLDGLGSGVTGTESKDKLEAFKKSIFIYLEPFINQLKNYDHTVCEENINEREDMFGIDPFYIPTGPNGKYSVTSFTFDAPTTKSNKLKILRGLQLKKPLLLEGSPGVGKTSLVSAIAKASGHNLLRINLSDQTDISDLFGADLPVEGGKGGQFAWRDGPFLRALRAGDWILLDELNLASQSVLEGLNACLDHRGEVYIPELARSFVVKPGTKLFACQNPLSQGGARRGLPKSFLNRFTQVFVDALSDDDLKIIANSQFKYVDKTIIDKIIEFNSVISTEAGVFWGYHGSPWEMNLRDITRWCELYYEMKMSSYKDARITATELIYVDRMRTADDKEKVRELFRNVLQLQSYVNKQPYIHVDEENLYFDNIILPRSENSYCVDHNLLVLRNQIPVLKSLALCVKMNWMPILIGESGTGKSSVVRVLAQLAGQKLRSIAVNSAMDTIEILGGFEQVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HIX2</accession>
    <name>A0A8J2HIX2_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 11">Serine hydroxymethyltransferase</fullName>
            <ecNumber evidence="5 11">2.1.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HICCMSTLAB_LOCUS10042</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="2 11">Interconversion of serine and glycine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine</text>
            <dbReference type="Rhea" id="RHEA:15481"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="EC" id="2.1.2.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10 11">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 11">One-carbon metabolism; tetrahydrofolate interconversion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 11">Belongs to the SHMT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.1" evidence="5 11"/>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5100969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HIX2"/>
    <dbReference type="OrthoDB" id="10265628at2759"/>
    <dbReference type="UniPathway" id="UPA00193"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004372">
        <property type="term" value="F:glycine hydroxymethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019264">
        <property type="term" value="P:glycine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00378">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000097">
        <property type="entry name" value="Serine hydroxymethyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00051">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001085">
        <property type="entry name" value="Ser_HO-MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049943">
        <property type="entry name" value="Ser_HO-MeTrfase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019798">
        <property type="entry name" value="Ser_HO-MeTrfase_PLP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039429">
        <property type="entry name" value="SHMT-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF000586">
        <property type="entry name" value="PRK00011.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11680">
        <property type="entry name" value="SERINE HYDROXYMETHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11680:SF59">
        <property type="entry name" value="SERINE HYDROXYMETHYLTRANSFERASE, CYTOSOLIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00464">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000412">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00096">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="9 10 11" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Serine hydroxymethyltransferase-like" evidence="12">
        <location>
            <begin position="67"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="10">
        <location>
            <position position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00016846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000412-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAG5100969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="520" mass="57607" checksum="AB262C7A3C3FC9C1" modified="2022-05-25" version="1">MVTRWPSLNIYVVRLAGNSLMNQHKPVKRASQGRVTKSMFFTRSIGTSSTCFNNDKMPGTLHQNLWESDPELFKLIKKEKQRQKSGLELIASENFTSLSVLQCLSSCLHNKYSEGLPGQRYYGGNEFIDEIELLAQKRALEAFNLDPEKWGCNVQPYSGSPANFAVYTGLIEPHGRIMGLDLPDGGHLTHGFFTPTKKISATSIFFESMPYKVDPSTGLIDYEKLAEHAKLFKPKIIIAGVSCYSRCLNYKKFREIADENGAYLFSDMAHISGLVAAGVIPSPFEYSDVVSTTTHKTLRGPRAGVIFFRKGLRSVGKNGEKIMYDFESKINQAVFPGLQGGPHNHAIAGIATAMKQANTPEFVNYQKQVIANAQQLCKSLQSFGYKISTDGTDVHLLLVDLRNTGITGSKAERILEDISIACNKNTVPGDKSAFNPSGIRLGTPALTTRGLKEENFEAVAEFIHRGLQLSKEVTAKSGPKLVDFKSVLENDSEIKVKVSALRHEVEKYANKFPMPGLEEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HJ06</accession>
    <name>A0A8J2HJ06_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Similar to Atad2: ATPase family AAA domain-containing protein 2 (Mus musculus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HICCMSTLAB_LOCUS9795</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5100722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HJ06"/>
    <dbReference type="OrthoDB" id="5421at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006334">
        <property type="term" value="P:nucleosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006337">
        <property type="term" value="P:nucleosome disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045815">
        <property type="term" value="P:transcription initiation-coupled chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000061">
        <property type="entry name" value="ATPase family, AAA domain-containing 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045199">
        <property type="entry name" value="ATAD2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000641">
        <property type="entry name" value="CbxX/CfxQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23069">
        <property type="entry name" value="AAA DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23069:SF0">
        <property type="entry name" value="TAT-BINDING HOMOLOG 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00819">
        <property type="entry name" value="CBXCFQXSUPER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="6">
        <location>
            <begin position="41"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAG5100722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="263" mass="29699" checksum="A6976145B587FB6A" modified="2022-05-25" version="1">MSNLKDFSFIGGLQKHIEIVKEMILFPLVYGELYSKFNLKPPRGLLFYGPPGTGKTLVASALAIECSNSERKVAFISRKGSDCLSKYVGESERKLRKIFHTAQQTKPCIIFFDEVDGLAPTRSSRQDFVHASVVSTLLALMDGLDNNSEIIVVGATNRLEAIDPALRRPGRFDRELYFPLPCYIARKDILSVYVKNWKQKPSVKFLAYLASKTVGYCGSDLQALCAEAVMCCVRRHYPQIYLSKTKLNINEKSLKVSFIKYYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HJQ7</accession>
    <name>A0A8J2HJQ7_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ras-related protein Rab-3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HICCMSTLAB_LOCUS11755</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5103929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HJQ7"/>
    <dbReference type="OrthoDB" id="9989112at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01865">
        <property type="entry name" value="Rab3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000206">
        <property type="entry name" value="Ras-related protein Rab-3C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037872">
        <property type="entry name" value="Rab3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050305">
        <property type="entry name" value="Small_GTPase_Rab"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47980">
        <property type="entry name" value="LD44762P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-0488">Methylation</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0636">Prenylation</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="193"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="208"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00067102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAG5103929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="222" mass="25074" checksum="C2C07F6C6632CB11" modified="2022-05-25" version="1">MAGQDPKWQKDAADQNFDYMFKLLIIGNSSVGKTSFLFRYADDSFTSAFVSTVGIDFKVKTVFRHDKRVKLQIWDTAGQERYRTITTAYYRGAMGFILMYDITNEESFNSVQDWITQIKTYSWDNAQVILVGNKCDMEDERVVSFERGKQLAEQLGVQFFETSAKENINVKAVFEQLVDIICDKMSESLDNDPALMAGGGGQAKGQKLTDQPANPSNPNCNC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HKH0</accession>
    <name>A0A8J2HKH0_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS9617</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5100544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HKH0"/>
    <dbReference type="OrthoDB" id="6076990at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5100544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="107" mass="11868" checksum="94987E1F1C623013" modified="2022-05-25" version="1">MSSSVECPALFSCETTGTDEYSLLSSQKATTETPGSNGGFVPLREFLDKFPLPRVVRIEDGGSRPILLYTQQPRSLRITATLLMHRYRHDIKVGPEIVIPEGYPGEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HKX3</accession>
    <name>A0A8J2HKX3_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to Ttc8: Tetratricopeptide repeat protein 8 (Mus musculus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS9555</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5100441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HKX3"/>
    <dbReference type="OrthoDB" id="421121at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034464">
        <property type="term" value="C:BBSome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097730">
        <property type="term" value="C:non-motile cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905515">
        <property type="term" value="P:non-motile cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd21341">
        <property type="entry name" value="TTC8_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028796">
        <property type="entry name" value="BBS8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44177">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44177:SF1">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="342"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="74"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="78"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5100441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="496" mass="56281" checksum="0FB95D71C90E8D45" modified="2022-05-25" version="1">MELFNAISLFNRRKYEECASICTNLLRKKPLDQAVWVLKMRALTLQLYVDDIEGEEEGIAESLLDNYTIASMPRPGTSLKNPGTSMVGQGIRPKTQSGRPVTGTIRPMTQSATAKTVEQALRTPRTAMTARPITTSSGRAVRLGTASMLSEPNGPFIQISRLNISKYASKSGIAKPLFEYIFYHEHDARNALDLAVQAIQASNFKDWWWKVQLGKCYYTLGLVRDAEEQFKSALKEHKNIDIVTRLIRVFIRLDQPLAALDLCKRGLEYFPNDVTILTEMARVFEGLNSTTMSVKYYKMVAQEDAANSEAIASIGMHHFYNDQPELGLRYYRRLLQMGVYNAELLNNLGLCCFYAQQWDHTISCFERALSLATNENAADIWYNISHIAIVRGDYVLAEECLRLAISIDNRHASSYNNLGVLEIKKGNVTAARTYFHAAASIVDYMHEPHFNSAYLAHQIGDLQTSYLAVQKSLYAYPSHLDTKLLFEQFQHHFFYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HKZ7</accession>
    <name>A0A8J2HKZ7_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to EFCAB10: EF-hand calcium-binding domain-containing protein 10 (Homo sapiens)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS10323</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5101250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HKZ7"/>
    <dbReference type="OrthoDB" id="10260455at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22981">
        <property type="entry name" value="DD_TbAK-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056587">
        <property type="entry name" value="EF_EFCAB10_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039879">
        <property type="entry name" value="EFC10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21847">
        <property type="entry name" value="EF-HAND CALCIUM-BINDING DOMAIN-CONTAINING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21847:SF1">
        <property type="entry name" value="EF-HAND CALCIUM-BINDING DOMAIN-CONTAINING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24548">
        <property type="entry name" value="EF_EFCAB10_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47391">
        <property type="entry name" value="Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF-hand" evidence="2">
        <location>
            <begin position="113"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5101250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="188" mass="20864" checksum="430017EAEFAB36B2" modified="2022-05-25" version="1">MSAQEAGSSKDKSKAPPKTRNYAEVKEDPLDTGLSKGENSQIGGCDSPQQTGNVCPKHKAHEYLTSHKIFELNNYLISHLLIDEPDNPIEYLADLIERCLLFKTGQGPPPLIFTDRHIDGIFQSFDPLHTGSITLDQYNTAIKLLGIADYNQNPRECVPGKVDKEVFHAEVKKCMINGVEEIIGKNSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HLC8</accession>
    <name>A0A8J2HLC8_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS11205</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5102830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HLC8"/>
    <dbReference type="OrthoDB" id="7700765at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5102830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="74" mass="8446" checksum="939F536F179FB2E4" modified="2022-05-25" version="1">MQVYENDCEAIDKQSSSEKKISPKAVRQDNSPKTPLKEIFTLPVEYLPKKKRSQVEKSGKSKLPSVGTSKEWYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HMQ6</accession>
    <name>A0A8J2HMQ6_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="5">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">HICCMSTLAB_LOCUS11834</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Mitochondrion outer membrane</location>
            <topology evidence="4">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="5"/>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5104102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HMQ6"/>
    <dbReference type="OrthoDB" id="1405469at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090141">
        <property type="term" value="P:positive regulation of mitochondrial fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042981">
        <property type="term" value="P:regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051511">
        <property type="entry name" value="MitoQC_Scaffold_Kinases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22972">
        <property type="entry name" value="SERINE/THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22972:SF7">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE PINK1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0418">Kinase</keyword>
    <keyword evidence="14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="11" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="15" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Protein kinase" evidence="19">
        <location>
            <begin position="173"/>
            <end position="560"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="CAG5104102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="586" mass="66213" checksum="F6455249B75C94B5" modified="2022-05-25" version="1">MSIRFLAQRLVQHGRIILHTLRNNELRYSNTHAKNHFIKIHVVPVGKSLGPTPQGTSNATHVRSHLGYLGAQARRIFVDNILRRVTNSLAGELRKKAANRHLFGDSAPFFALVGVSLASGTGILTKDDELEGVCWEIREAVSKLQWMKPENDRNYESPEIEKQPTSTTSLQDFVFGPAIAKGCSAVVYAARFKEETLNTTASKVDGPIVKADDEDVANFPLAIKMMFNYDAESNSMAILRAMYRETVPARKYERGELTDWELRIADNKRALPPHPNVVAMYHVFTDRIPYLPGSWQLYPDALPARINPEGSGRNMSLFLLMKRYDITLKEYMVDHPVNIQESVLLFAQLLEGIAHINAHGIAHRDLKSDNILLDISEETDNCPSLVITDFGSCLADKRHGLYLPFNSHDVDKGGNIALMAPEVVTAEPGPFTSINYTKADLWTAGTIAYEIFGMVNPFYGGKNETAQLKNYTYSDTTIMQLYLWAPSAWLRKRNKLPSSNEILQWLLCLTTKVLCEGREIEILNSMPSSSQDEKVEKKNYRRLISTRLSGRRTMPEYQLIASFLGRVSLYNVREGLQWIDRNTNFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HP40</accession>
    <name>A0A8J2HP40_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ABC-type xenobiotic transporter</fullName>
            <ecNumber evidence="3">7.6.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">HICCMSTLAB_LOCUS11508</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>ATP + H2O + xenobioticSide 1 = ADP + phosphate + xenobioticSide 2.</text>
            <dbReference type="EC" id="7.6.2.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.6.2.2" evidence="3"/>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5103435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015421">
        <property type="term" value="F:ABC-type oligopeptide transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008559">
        <property type="term" value="F:ABC-type xenobiotic transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090374">
        <property type="term" value="P:oligopeptide export from mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097254">
        <property type="term" value="P:renal tubular secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017085">
        <property type="term" value="P:response to insecticide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd18577">
        <property type="entry name" value="ABC_6TM_Pgp_ABCB1_D1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18578">
        <property type="entry name" value="ABC_6TM_Pgp_ABCB1_D2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03249">
        <property type="entry name" value="ABC_MTABC3_MDL1_MDL2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000009">
        <property type="entry name" value="ABC transporter B family member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000018">
        <property type="entry name" value="ATP-binding cassette subfamily B member 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000302">
        <property type="entry name" value="ATP-binding cassette subfamily B member 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000479">
        <property type="entry name" value="Multidrug resistance protein 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394">
        <property type="entry name" value="ATP-DEPENDENT PERMEASE MDL1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394:SF27">
        <property type="entry name" value="ATP-DEPENDENT TRANSLOCASE ABCB1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 18" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-1278">Translocase</keyword>
    <keyword evidence="5 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="99"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="173"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="251"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="277"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="357"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="393"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="773"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="819"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="899"/>
            <end position="919"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="925"/>
            <end position="946"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="1005"/>
            <end position="1026"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="17">
        <location>
            <begin position="103"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="16">
        <location>
            <begin position="459"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="17">
        <location>
            <begin position="781"/>
            <end position="1066"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="16">
        <location>
            <begin position="1103"/>
            <end position="1341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="30"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00034018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="CAG5103435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="1347" mass="147698" checksum="FCE853D030CFC33F" modified="2022-05-25" version="1">MTQRIYQWSTNPLEGAPQSIQMEPPKTKSNHQEKIPLRYTQQDKEKDKQETECILDDDNEPIEFVPPQTKEEDKPPPEAPSVPPIPYYKLFRFATFGELMYVFAGLFMGTMTGLCIPVANIQYGEFTTLLVDRNMTNQTSTPTFVMEMFGGGKILGPNASKEERMNALYDDSVAFGVSCAALSTFQFIFAIFTVDLLNVAAFRQIHRIRRMFLQAVLRQDMSWYDTNTSTNFASRITEDLDKMKEGMGEKLGVFTYLTVSFVSSIIVSFYYGWKLTLVVLSCAPVIVIATAIVAKVQSSLTALELTAYGQAGSVAEEVLGAIRTVVAFGGEKVEVNRYTAKLVPAEKTGIKRGMWSGVGGGIMWFIIYLSYAVAFWYGVQLILEDRPKLEKEYTPAVLVIVFFGVLAGAQNMGLTSPHLEAFAVARGSAATVFQVIDRVPTIDSLSTQGQKLPSVNGDIEFKDVYFKYPARKDVKVLQGLNLKIKSGETVALVGGSGCGKSTCLQLIQRLYDPLQGQVMLDGVDIAKLNVGWMRSYIGVVGQEPVLFDTTIRENIRYGNDNVTEEEMIKAAKEANAHDFISKLPEGYDSPVGERGSQLSGGQKQRIAIARALVRKPKILILDEATSALDLHSEATVQRALDAAAKGRTTVVVTHRLSTITNADRIVFIKDGQVAEMGTHEELLALGNHYYGLVSADASTTAKAKATATVAKSTVAAVPKAKPPLKKQFSTLSMHSHRLSLAGASTTSEEELDEHEKPYDAPMRRIFGLNKQEWLFNLIGNSCLAAATVGASFPAFAMLFGDVYYVLGLENPDEVREKTITFSIYFGIVGVVTGIGTFLQMYMFGLAGVKMTARIRKMTFTAMLKQEMGWYDEDTNSVGALCARLSSDAAAVQGATGSRIGAILQALSTLVLGIGLSMYYSPEMTLVSVVSIPLVLGAVFFEARIMGGQGMQEKKKMECATRIAVEAISNIRTVASLGKEKAFLERYCVELNHVAKATRVKNRLRGLVFSCGQTIPYFGYALSLYYGGYLAARKDLPYQDVIKVSEALIFGSWMLGQALAFAPNFNTAKISAGRIFRLLDRVPEILTPPEMEGKDLDWKADGLIQFSKVEFHYPTRTEQQILRGLNLIVKPGQMVALVGQSGCGKSTCIQLLQRLYDPLTGSVTMDRRDITSVSLSALRAQFGVVGQEPVLFDRTIAENIMYGDNNRVVTMDEVIEAAKKSNIHSFISSLPLGYDTRLGSKGTQLSGGQKQRIAIARALVRNPRILLLDEATSALDTQSEKVVQAALDKAMEGRTCITIAHRLATIKNADVICVLEKGMVAEMGTHDDLIAADGLYAHLHALQEAAME</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HP81</accession>
    <name>A0A8J2HP81_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Similar to Mad: Protein mothers against dpp (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HICCMSTLAB_LOCUS12186</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5106290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HP81"/>
    <dbReference type="OrthoDB" id="5794312at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071144">
        <property type="term" value="C:heteromeric SMAD protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070411">
        <property type="term" value="F:I-SMAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009653">
        <property type="term" value="P:anatomical structure morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030509">
        <property type="term" value="P:BMP signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060395">
        <property type="term" value="P:SMAD protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.520.10">
        <property type="entry name" value="SMAD MH1 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013790">
        <property type="entry name" value="Dwarfin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003619">
        <property type="entry name" value="MAD_homology1_Dwarfin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036578">
        <property type="entry name" value="SMAD_MH1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13703:SF61">
        <property type="entry name" value="PROTEIN MOTHERS AGAINST DPP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13703">
        <property type="entry name" value="SMAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03165">
        <property type="entry name" value="MH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00523">
        <property type="entry name" value="DWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56366">
        <property type="entry name" value="SMAD MH1 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="MAD homology 1 Dwarfin-type" evidence="5">
        <location>
            <begin position="38"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAG5106290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="175" mass="19699" checksum="E09758F7CB23C3CB" modified="2022-05-25" version="1">MDDDEGTSSSGPVSSLNSLFSFTSPAVKKLLGWKQGDEEEKWAEKAVDSGSMIFDPPTKYPRQIIPKTKITRQNILNKPKGAIEDLEHALSCPGTSRKCVTIPRSLNRRLQVSHRKGLLHVIYSKQKEVCINPYHYKPVESPVLPLVLVPRHSEYAPGHSLLPFAQILYYQYPVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HPJ4</accession>
    <name>A0A8J2HPJ4_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Similar to PTH1R: Parathyroid hormone/parathyroid hormone-related peptide receptor (Bos taurus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">HICCMSTLAB_LOCUS11671</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G-protein coupled receptor 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5103761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HPJ4"/>
    <dbReference type="OrthoDB" id="16753at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008528">
        <property type="term" value="F:G protein-coupled peptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017046">
        <property type="term" value="F:peptide hormone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007188">
        <property type="term" value="P:adenylate cyclase-modulating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007166">
        <property type="term" value="P:cell surface receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1240.10">
        <property type="entry name" value="GPCR, family 2, extracellular hormone receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050332">
        <property type="entry name" value="GPCR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017981">
        <property type="entry name" value="GPCR_2-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036445">
        <property type="entry name" value="GPCR_2_extracell_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001879">
        <property type="entry name" value="GPCR_2_extracellular_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000832">
        <property type="entry name" value="GPCR_2_secretin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017983">
        <property type="entry name" value="GPCR_2_secretin-like_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45620:SF1">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 2 PROFILE 2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45620">
        <property type="entry name" value="PDF RECEPTOR-LIKE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00002">
        <property type="entry name" value="7tm_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02793">
        <property type="entry name" value="HRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00249">
        <property type="entry name" value="GPCRSECRETIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00008">
        <property type="entry name" value="HormR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111418">
        <property type="entry name" value="Hormone receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00649">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50227">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50261">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 14" id="KW-0675">Receptor</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="147"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="178"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="243"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="269"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="308"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 1" evidence="12">
        <location>
            <begin position="49"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 2" evidence="13">
        <location>
            <begin position="141"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CAG5103761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="451" mass="51047" checksum="E00B0F107861C2A0" modified="2022-05-25" version="1">MEIVTTDADYGIVTVKDDIDFNSPVIQGRMLEMQAQRCNNGSTPRAGWCPETWDSILCWPPTAPNELAVLSCPHYIAGFDLQANATRQCMSDGQWYWSAETNSTWSNYTECYNTPLVTVLMDLPDMEADNATLVKKYLPVVKIISTVGYAVSLSALIVAFCILATIKKLRCPRNMLHMHLFASFITRAFMALLKEIIFISGLGLSSDVLIKNGESYWLDHDIESNWHCKAFTSFWQYAILANYSWILMEGLYLHNLVFFALFTDSNSSIAGYVALGWGLPLVFVLPWISMRACIEDTFCWTINLNPYVFSVIRIPTTLSIVINFALFVNIVRVLYLKLKSAVCEETHRYRRWARNVTTRGCSLASSRGYLDSVDHGHGINLPDGYVQTTNQASPLRSKYTDQSMLSFYSNISEGCGLTSNLTYKIEPSEHHRWSDSECCSLSFELHNFHPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HPL3</accession>
    <name>A0A8J2HPL3_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 6">Histone deacetylase complex subunit SAP18</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HICCMSTLAB_LOCUS11077</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Involved in the tethering of the SIN3 complex to core histone proteins.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the SAP18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5102562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HPL3"/>
    <dbReference type="OrthoDB" id="440566at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.550:FF:000001">
        <property type="entry name" value="Histone deacetylase complex subunit SAP18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.550">
        <property type="entry name" value="ASAP complex, SAP18 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017250">
        <property type="entry name" value="Hist_deAcase_cplx_SAP18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010516">
        <property type="entry name" value="SAP18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042534">
        <property type="entry name" value="SAP18_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13082:SF0">
        <property type="entry name" value="HISTONE DEACETYLASE COMPLEX SUBUNIT SAP18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13082">
        <property type="entry name" value="SAP18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06487">
        <property type="entry name" value="SAP18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037637">
        <property type="entry name" value="HDAC_SAP18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0678">Repressor</keyword>
    <keyword evidence="5 6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 6" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR037637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAG5102562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="155" mass="17577" checksum="FAF0AECEF2CC04FF" modified="2022-05-25" version="1">MASMVESMVVDDKQLPEKPVDREKTCPLLLRVFCNTGRHHNIMDYSRGNVPSNELQIYTWMDATLREITGLVKEVNPDARSKGTYFEFSLVTPEARNSGYRMREIGVTCSGQKGADDNKTLAQVRFTIGDYLDISITPPNRMMQPAARRGGLRQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HPT2</accession>
    <name>A0A8J2HPT2_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial</fullName>
            <ecNumber evidence="7">6.2.1.4</ecNumber>
            <ecNumber evidence="7">6.2.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Succinyl-CoA synthetase subunit alpha</fullName>
            <shortName evidence="7">SCS-alpha</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HICCMSTLAB_LOCUS13030</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="5 7">Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and specificity for either ATP or GTP is provided by different beta subunits.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>GTP + succinate + CoA = succinyl-CoA + GDP + phosphate</text>
            <dbReference type="Rhea" id="RHEA:22120"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="6.2.1.4"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>succinate + ATP + CoA = succinyl-CoA + ADP + phosphate</text>
            <dbReference type="Rhea" id="RHEA:17661"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.2.1.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 7">Carbohydrate metabolism; tricarboxylic acid cycle; succinate from succinyl-CoA (ligase route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Heterodimer of an alpha and a beta subunit. Different beta subunits determine nucleotide specificity. Together with an ATP-specific beta subunit, forms an ADP-forming succinyl-CoA synthetase (A-SCS). Together with a GTP-specific beta subunit forms a GDP-forming succinyl-CoA synthetase (G-SCS).</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Heterodimer of an alpha and a beta subunit. Different beta subunits determine nucleotide specificity. Together with the ATP-specific beta subunit SUCLA2, forms an ADP-forming succinyl-CoA synthetase (A-SCS). Together with the GTP-specific beta subunit SUCLG2 forms a GDP-forming succinyl-CoA synthetase (G-SCS).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7 9">Belongs to the succinate/malate CoA ligase alpha subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.4" evidence="7"/>
    <dbReference type="EC" id="6.2.1.5" evidence="7"/>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5108023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HPT2"/>
    <dbReference type="OrthoDB" id="1664372at2759"/>
    <dbReference type="UniPathway" id="UPA00223">
        <property type="reaction ID" value="UER00999"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009361">
        <property type="term" value="C:succinate-CoA ligase complex (ADP-forming)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004775">
        <property type="term" value="F:succinate-CoA ligase (ADP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004776">
        <property type="term" value="F:succinate-CoA ligase (GDP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000002">
        <property type="entry name" value="Succinate--CoA ligase [ADP-forming] subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.261:FF:000005">
        <property type="entry name" value="Succinate--CoA ligase [ADP-forming] subunit alpha, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.261">
        <property type="entry name" value="Succinyl-CoA synthetase domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01988">
        <property type="entry name" value="Succ_CoA_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017440">
        <property type="entry name" value="Cit_synth/succinyl-CoA_lig_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033847">
        <property type="entry name" value="Citrt_syn/SCS-alpha_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003781">
        <property type="entry name" value="CoA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005810">
        <property type="entry name" value="CoA_lig_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005811">
        <property type="entry name" value="SUCC_ACL_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016102">
        <property type="entry name" value="Succinyl-CoA_synth-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004230">
        <property type="entry name" value="PRK05678.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01019">
        <property type="entry name" value="sucCoAalpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11117:SF2">
        <property type="entry name" value="SUCCINATE--COA LIGASE [ADP_GDP-FORMING] SUBUNIT ALPHA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11117">
        <property type="entry name" value="SUCCINYL-COA LIGASE SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02629">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00549">
        <property type="entry name" value="Ligase_CoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001553">
        <property type="entry name" value="SucCS_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01798">
        <property type="entry name" value="SCOASYNTHASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00881">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52210">
        <property type="entry name" value="Succinyl-CoA synthetase domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01216">
        <property type="entry name" value="SUCCINYL_COA_LIG_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00399">
        <property type="entry name" value="SUCCINYL_COA_LIG_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="CoA-binding" evidence="10">
        <location>
            <begin position="36"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-phosphohistidine intermediate" evidence="7 8">
        <location>
            <position position="284"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="49"/>
            <end position="52"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="75"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="128"/>
            <end position="130"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="192"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared with subunit beta</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00054246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00061754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR001553-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAG5108023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="333" mass="35001" checksum="0CE7834C5FD7CAA0" modified="2022-05-25" version="1">MAVAARAFSKLTVRRSSSLLASQVRFNYTETRKNLKIDSNTKVICQGFTGKQGTFHCQQAIDYGTKVVGGVSPKKAGTEHLGKPVFKTVKEAKEATGATASVIYVPPPAAAAAIMEALDAEMPLIVCITEGIPQHDMVKVKRRLLEQNKSRLIGPNCPGIIAPEQCKIGIMPGHIHQKGKIGIVSRSGTLTYEAVNQTTLTGLGQSLCVGIGGDPFNGTDFIDCLEVFINDPATSGIIMIGEIGGSAEESAAEYLIQHNSGSNAKPVVSFIAGVTAPPGRRMGHAGAIISGGKGGAQDKINALEKAGVIVTRSPAQMGRELLKEMTRLGLHSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HPT7</accession>
    <name>A0A8J2HPT7_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HICCMSTLAB_LOCUS12654</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5107248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="431717at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008630">
        <property type="term" value="P:intrinsic apoptotic signaling pathway in response to DNA damage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1070.11">
        <property type="entry name" value="Phosphatidylinositol 3-/4-kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1010.10">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050517">
        <property type="entry name" value="DDR_Repair_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046804">
        <property type="entry name" value="DNA-PKcs_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046803">
        <property type="entry name" value="DNAPKcs_CC1-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012582">
        <property type="entry name" value="DNAPKcs_CC3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045581">
        <property type="entry name" value="DNAPKcs_CC5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003152">
        <property type="entry name" value="FATC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000403">
        <property type="entry name" value="PI3/4_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036940">
        <property type="entry name" value="PI3/4_kinase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018936">
        <property type="entry name" value="PI3/4_kinase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11139">
        <property type="entry name" value="ATAXIA TELANGIECTASIA MUTATED ATM -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11139:SF68">
        <property type="entry name" value="DNA-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20500">
        <property type="entry name" value="DNA-PKcs_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20502">
        <property type="entry name" value="DNAPKcs_CC1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08163">
        <property type="entry name" value="DNAPKcs_CC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19704">
        <property type="entry name" value="DNAPKcs_CC5"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02260">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00454">
        <property type="entry name" value="PI3_PI4_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01343">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01344">
        <property type="entry name" value="NUC194"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00146">
        <property type="entry name" value="PI3Kc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51190">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00916">
        <property type="entry name" value="PI3_4_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50290">
        <property type="entry name" value="PI3_4_KINASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PI3K/PI4K catalytic" evidence="7">
        <location>
            <begin position="3427"/>
            <end position="3753"/>
        </location>
    </feature>
    <feature type="domain" description="FATC" evidence="8">
        <location>
            <begin position="3795"/>
            <end position="3827"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAG5107248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="3827" mass="443226" checksum="69616D982B102D05" modified="2022-05-25" version="1">MDSVKEFMNIFSRCWKERRGEELERLFKDGPQYFQDVPQSFKALALITVFDKKNGLTVFLTKEIDRPVIDKNLQLSFHAAFHLIQFFINEYSDVLLPHVILIKKLCTFIATLKTAAYLHRISCMTLIMLIEKFHTMDLQLDETLCYWLTKFNLFSDKGVIVRYYPDIEIINEQKDLIKNCAMKLLDKMYNTMRYEKPHILQTNIESLMDLLYNFPPDENDPEIIKFYERVKEVVEGAGEASKSGIIRALIKLMTQQMFTFKNLVFRDHEFWQNKLKCYRDDEQYSDLATPALQVYYEVIAKVLSERAHENNQNVKAVLHSLKGMFVSNLTEDLMLKDLRLNINGLSQFAEPIKKAYNDIVVEEIYSLVASHVMPLYFSEEEAHEYFEDISDYQESLSRILVNISNISHDQIKAILKLSILLIKRYPELSPLSQRNAIDSLKRTFSNISKFKLRVSQEYIKNLVFESIVWSCSHSLLIDAEHQRDIENLPKRPLCYKDYVPLWKGLLNSTNDEISVQQQVVNEIIEACIELIKTLNLKIKTREDNTFSDIAASQIAENETDFRIFHNMVDLYDEIFEDIIPYDPKDKFTRFLYQVIRASYQYPLIAGFYRLTDRILNAKYFIEDYIEDKELNKMVVQYLQNTIDSIGKFPQELQVSCIHLVLHTPVVFLSYLIDQSIPIFKIALTIGLSDYDLANSALTALENYVCTINSEKLNEFVRELLPNLEMYLRSKESFQIYNESFDANEKSVFNNDEGLEKLQKRILLLFGRFEQSTVLEFLYTQSLNTGASWDKKDLLKYSLHFPDYTLDVYLDTMLPRIVELAVNSSDRRSKVAASEVLHSLVSIVLGKTVQYLSADADRFAPLYKTLCPVLLRLGCDADDVIRQIFNPLVLQLTHWLSSKLMLYSPSVCYLVDALFDGLSDETNSTLRDFSGVCLAEFAKWTIKQSTDQDLLRAPININTIVENITNFALHPSKNRRIAAAIAFNYLHKTLATHQEIVSVFWLELLYAFMKSLNGCHDTSIQISLENVKKVLMNRSRIFNQIEPRRKVPVEFEGGTLEDTVNWLLYQCESLDTNVRKKSMELFVALSSKVEAHKSPKNFMMAFLENDGIQGLNTIILKDSADVMFEINLNSEKAEKFLKIILRMLDCYIWILRADLIDGDNLLFEPVNLERRRIFNCIKCFIESVLNLQDEENNFIQCLAKINGLVCEAILILFDFIIVILTTEFLEKNWALQELFNQNLYSLISRCVIEPHKVGFDVKNLLATESLPLKLEELLITLKTKLPGEYLNCMENELKSTVENLCPFLFNFEEDQNYKLQVNSVKGLLLLNKCKILHKLKVTNLSSHTSEAIDQIFNSLKVGESDQWYIELSSDKKKYFEVLLKLLLSYQSKAVSKIIGRLIADRNLEGAPQSKITHGEYFFNTFRDVLIPCLLNDIDDTMKELTNLLQINADVSLFITEEMVVWVLKHKNDYQDILEQLSDELIGRFEDYKRVLNNLEMRKKLFRSIFRTVVRFKNNPLEISFARGPMYAWILKELNETNDLLKKINVLSDFLICLTGENSHSPEIRVLLDGLKQAREAECTGGITGKTLMNSKIKECLQKLIVLLPITKSTDVFYATINFSIGVGDYLFNEATFTCIDNFFSHVVHDALEHIEVAYDLFMTKTIVRERLDVLKHFLLPGLRACNSFTREQFFNKYIKDIFGTIIRTTTNNLADDKKLIVSQIGCYNFIELMFSNLSLEKINNNEGVIAKSILGNSSNELVTQRIFKCTYQIRSFKSSVLDFQEIVRLLHCAAYNCAITIASETKDSKYYLSLFAENRSNGQLIWENIVDCKKVYELSQTFKEYPKQRKKLVNIRQAVRERQNDPSVYTYIKSYDLATSTLNENVYAHDFNEVSLREPSAEKSVTVTLEVDDFNNHECMAPICAILEIISETGPGFIIPDPNNPPRGLTLFAGSMGHVHKNAKLFMLKVILNNQKIFRPYARLFLAQIIDIIILLLDDGPLNYIITDGLLMLVDWAELAIPDEKLRQPANQLFSLLVDKVDEGLPSEYIIRYNFRIIEVLIQVWHKILTLPQGLELRMKCTRDKAIRVILILLANNMATDLICRPDILDYLINSLKEEWNAREEVVLHTCEAIGLFIKFSRTEENEDFEVESDITEKIHPVLRSLQHKNSDRLVKCIHVMVNAYPLLAGEFFNHIIDNFSKVAPPSMAKCLEVFLQRIPHMSPENIIRDLNYIKFYELLSNKVISCEKVCLEIVENLVVIIDPARLVSIAETVESYAQHESPAYRKLMYNIFINIYKKYSVDITDLADIQKLVDMSKKILLRGLLDPFEELQSKLMTFWTEEVGLREKCTDRILDILDIYSPEAEKDFLTIFAIIFLHMTKKSPSYNQVMFEPLNQSCNYRDYAIAISWRMKNLSYKIPLFTSSYVNHYSQRHSFSSLNVDNIPENDSDLMLRATMNTPASWMDRSLTNESFVATPSTSTLRVDDVFVIPKTQSLNVISRRFPKEFPDSKTTNINRKLEHYHKREEILRQQLNKQRNDVRLNRTYRIGDFPDISITPEAVLIPLQELLKKDNLICKDLAVSMIHSLIDQVRNQSRTKGDNNYNDFIKKFELKLNTILENHRESGHIIAMILEMMFRVENIKFDSSTIARVSKATDFNCLGALLLERNLITGSDEPPTKKIRLNESSASESSITESDFTDEWVQLADLYESTNQVDVVLSIFQNHVRNLPELSQASAARANNKWEDALQSYEGALNHYNLNISEAGVIQRHCQQSVFECLARLSNWAQIIGEIELKVENNSLESFIEVAKSPGGWFAPWYFKAFIYQYFTIDSRDQAEFERTRKFNEDLAVFLKIEAKVKLLKELFAEDIAAVCVTSNQERSQDLIDTALDQVREQWFQLSPLSTALRSRQVTKLRGISNVDVYYKATVSNQNKNLSILKNYWSTSYPHQRDDLLPWDMHIACRENFSKSLKENFMDEDSSMEGLGNEVEGLLTKLKFHMIEAAFQQRNKCLMRRYLFSIVNSSDKSTPEFTLQRGKYNILSAQLGSAEDKLKQYTLCWNRAQRIVIDEETDINTRINTRQFISEMATNLIDIGSSDQQLFQQIVNKIEQNIVEYMEDSNDVINGLNLCSVSNLKACCIEASRHSLEDSKVRDCYLKLLKYCHGKILTGEVSSDLIKEFVNSTLRAMLYNSQEAANYFPCLLNVDYLQDAETKRIFKALTQKIPLWRFLKWQAQLLYNLSTPLEDVVAPIIRNLFQKYPNALIYSLRLAMDTNPHVKNHPVIQEQMQLLSNQVELENFIEAMEYLVKPELYLQYYLKKLKGNSVFNAESFDFILKKIYPDVKSLQGNLYKKISKYHEEIKHFKTISQEEFVNHLNKIMRELTLQAEKSKDSNSLKDYSPWLSNLSGTDIEIPGQYSGDSEPFPKYHAKIMKIEPKVHVIKSKSKPIKITIIGNDAKNYNFLVKFGEDLRLDERVEQAFGIMNEILRADIACSQRNLTINTYQIIALSGSLGLIQWIDNTRSLNEYINFDMNEEQKKRHGRIREEYVSWMGRASPNANPIVQYKEALIKYNSEAVVGKMNELIARTEWDLLRRTFFKLNPSLESFITSRRNFVVTYATMCVAHWILGIGDRHLENTLIKVESGKCTGIDFESAFGGGIDQVLPECMPFRLTSQIKGLMKPFDENDEFKTIMTLVLTGLRNCKEPLLAYLGVVASENLNWSEHAQQLMEKIQHDYHTTNVNWLPKNKFNYISRKLNGEKPSEITLKELENQHSDEKYYSRYSAILKGKDDDQSSMRMRIRDGNLTPEEQVKCLLDQATDLNILGRTYAGWSPWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HQD5</accession>
    <name>A0A8J2HQD5_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS11181</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5102782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HQD5"/>
    <dbReference type="OrthoDB" id="7694747at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5102782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="74" mass="8189" checksum="75F99738EB047A8F" modified="2022-05-25" version="1">MSYTTALQKEVVPTKEQAVILDSGEGIQLQSYAIAIGTKIGPQNIRYISRIANNRICVYLATKEIADQLIVVHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HQM5</accession>
    <name>A0A8J2HQM5_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Delta-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">HICCMSTLAB_LOCUS12501</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="18">Putative Notch ligand involved in the mediation of Notch signaling.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell projection</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3 18">Membrane</location>
            <topology evidence="3 18">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="16">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="23">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5106920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HQM5"/>
    <dbReference type="OrthoDB" id="283575at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045179">
        <property type="term" value="C:apical cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042995">
        <property type="term" value="C:cell projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043208">
        <property type="term" value="F:glycosphingolipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005112">
        <property type="term" value="F:Notch binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048018">
        <property type="term" value="F:receptor ligand activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000902">
        <property type="term" value="P:cell morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030855">
        <property type="term" value="P:epithelial cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035214">
        <property type="term" value="P:eye-antennal disc development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030718">
        <property type="term" value="P:germ-line stem cell population maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042063">
        <property type="term" value="P:gliogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036011">
        <property type="term" value="P:imaginal disc-derived leg segmentation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008587">
        <property type="term" value="P:imaginal disc-derived wing margin morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046331">
        <property type="term" value="P:lateral inhibition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048666">
        <property type="term" value="P:neuron development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007219">
        <property type="term" value="P:Notch signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016330">
        <property type="term" value="P:second mitotic wave involved in compound eye morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035239">
        <property type="term" value="P:tube morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048100">
        <property type="term" value="P:wing disc anterior/posterior pattern formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000018">
        <property type="entry name" value="Delta-like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000061">
        <property type="entry name" value="Delta-like protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000230">
        <property type="entry name" value="Delta-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000294">
        <property type="entry name" value="Delta-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.140:FF:000001">
        <property type="entry name" value="Delta-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000318">
        <property type="entry name" value="Eyes shut homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000122">
        <property type="entry name" value="Protein crumbs homolog 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000255">
        <property type="entry name" value="Sushi, nidogen and EGF-like domains 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000472">
        <property type="entry name" value="Uncharacterized protein, isoform A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001774">
        <property type="entry name" value="DSL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013032">
        <property type="entry name" value="EGF-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000152">
        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018097">
        <property type="entry name" value="EGF_Ca-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056986">
        <property type="entry name" value="JAG1_1/2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026219">
        <property type="entry name" value="Jagged/Serrate"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050906">
        <property type="entry name" value="Notch_signaling"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001007">
        <property type="entry name" value="VWF_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24044">
        <property type="entry name" value="NOTCH LIGAND FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24044:SF421">
        <property type="entry name" value="PROTEIN JAGGED-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01414">
        <property type="entry name" value="DSL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00008">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21700">
        <property type="entry name" value="EGF_DL_JAG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23106">
        <property type="entry name" value="EGF_Teneurin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12661">
        <property type="entry name" value="hEGF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23575">
        <property type="entry name" value="JAG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00010">
        <property type="entry name" value="EGFBLOOD"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02059">
        <property type="entry name" value="JAGGEDFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00051">
        <property type="entry name" value="DSL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="16"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SMART" id="SM00215">
        <property type="entry name" value="VWC_out"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00010">
        <property type="entry name" value="ASX_HYDROXYL"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51051">
        <property type="entry name" value="DSL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01187">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="15" id="KW-0966">Cell projection</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="14" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4 18" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="12 16 18" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6 16 18" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11 18 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 18" id="KW-0677">Repeat</keyword>
    <keyword evidence="8 18" id="KW-0732">Signal</keyword>
    <keyword evidence="7 18 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 18 20" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="938"/>
            <end position="961"/>
        </location>
    </feature>
    <feature type="domain" description="DSL" evidence="22">
        <location>
            <begin position="96"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="21">
        <location>
            <begin position="141"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="21">
        <location>
            <begin position="208"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="21">
        <location>
            <begin position="248"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="21">
        <location>
            <begin position="286"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="21">
        <location>
            <begin position="340"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="21">
        <location>
            <begin position="377"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="21">
        <location>
            <begin position="415"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="21">
        <location>
            <begin position="463"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="21">
        <location>
            <begin position="499"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="21">
        <location>
            <begin position="537"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="21">
        <location>
            <begin position="575"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="21">
        <location>
            <begin position="613"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="21">
        <location>
            <begin position="652"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="21">
        <location>
            <begin position="690"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="970"/>
            <end position="1016"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1081"/>
            <end position="1104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="1087"/>
            <end position="1101"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="17">
        <location>
            <begin position="98"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="17">
        <location>
            <begin position="111"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="17">
        <location>
            <begin position="131"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="16">
        <location>
            <begin position="164"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="16">
        <location>
            <begin position="236"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="16">
        <location>
            <begin position="274"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="16">
        <location>
            <begin position="312"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="16">
        <location>
            <begin position="344"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="16">
        <location>
            <begin position="365"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="16">
        <location>
            <begin position="403"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="16">
        <location>
            <begin position="441"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="16">
        <location>
            <begin position="487"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="16">
        <location>
            <begin position="525"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="16">
        <location>
            <begin position="563"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="16">
        <location>
            <begin position="601"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="16">
        <location>
            <begin position="640"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="16">
        <location>
            <begin position="678"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="16">
        <location>
            <begin position="716"/>
            <end position="725"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU280815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS51051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="CAG5106920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="1112" mass="119873" checksum="50571700CB768041" modified="2022-05-25" version="1">MYHFLAAVTIFGRLYLPCLDTDYIFVRQFPSGHNRLPLIDLNLFQRQFTLILQARDEPNGGVIEEASYSGIVLPGTTWHTLNHQGRNAHLTYRLRVQCADHYYNATCTKFCRPRDDIFGHYTCDENGDKVCIHGWKGADCETAVCKEGCHPIHGHCNASGECKCRHGWRGDLCDQCTPYPGCKHGYCNGSSWQCICDTNWGGILCDQDLNYCGTHEPCQNGGTCENTAPDQYRCTCPDGFSGSTCEKVDNPCASNPCLNGATCVELGETAECQCAPGFSGPYCATDVDECASQPCQNGGTCVDEKNQFICHCPAAWQGTLCQFDSRRAKTLLPASTLLEITDDCVGQCQHGALCIDLVNDYHCSCNPGYSGKDCDVDIDECASKPCQNGGECRDLVNTYECVCPVGFTGHQCEIVKDHCTPNPCRNSSPCFNTQSDYYCHCPVQWQGKNCSELAVDNPRPDDGSPGCGSEGTPCNGRGRCSNGVCVCDPGYTGQRCHENINDCRGNPCLNGGTCVDLINSFQCICQEGWTGDLCDEDVDECTNAPCRNNGTCIDGVADFTCECRGGWKGKTCTLRGGHCEPGTCRHGGTCQDHGDGFTCHCPPGWEGAACHIASPACASSPCENGATCVNTADGGYRCICREGFEGPNCRKDVDDCQPLPCLNGGRCVDGVNWFRCECAPGFTGPDCRINVNECASDPCMGGATCIDGIASYSCICPPGRTGIHCEIRTASGAGCSATTWDNDCNVCECRNAKNQCSNVWCGQGNCLNGTSCLAHEVCVPSPGESCLAPPCSPWGECRPVETGRRVGPPALPAPPTCWPGQAIPGPTCSRLTILLRRDTLAPGTSVELLCRQLRRLLADPRRPQSLVLLCDLKPGDNDTIEVTIFSEAAVDAARDLGEALSRPISRPLALASVLEVKVETALLTDPITASNSPGSSGYVAVLGGALATVLILALLGGLWYLRSRQRSGLTATTSSETSLHRHRSDLDEKSNNLQNEENLRRYANPLKDSDTGEPRVSIVRPLSGMSLGALGPAEESLEMVAEEGRHRLPPLYKPTSAEARNNTASFSYEESLHKPYTKPRLQEPAYSHQQTPQQQPGTSAQIVPRQVLTVHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HQM7</accession>
    <name>A0A8J2HQM7_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Similar to PCMT1: Protein-L-isoaspartate(D-aspartate) O-methyltransferase (Gallus gallus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HICCMSTLAB_LOCUS13749</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5109113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HQM7"/>
    <dbReference type="OrthoDB" id="73890at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004719">
        <property type="term" value="F:protein-L-isoaspartate (D-aspartate) O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000218">
        <property type="entry name" value="facilitated trehalose transporter Tret1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025714">
        <property type="entry name" value="Methyltranfer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050549">
        <property type="entry name" value="MFS_Trehalose_Transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000682">
        <property type="entry name" value="PCMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48021">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48021:SF33">
        <property type="entry name" value="AT22075P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13847">
        <property type="entry name" value="Methyltransf_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01279">
        <property type="entry name" value="PCMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="6 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="224"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="249"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="282"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="306"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="393"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="427"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="477"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="513"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="543"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="137"/>
            <end position="569"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAG5109113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="608" mass="67353" checksum="CCC4A5A26E9D9237" modified="2022-05-25" version="1">MTWHCNGTTNQEMIDKLKAWLHAYALSFLSDQLKTGARALDVGSGSGYLTACMANMVGPQGRVIGIEHIPELIEISIRNIQKDCPNFIEEGRIKFLEADGREGYPTDSPYDAIHVGAAADFVPEQLIEQLAPGGRMIIPVVAMEGFQKFQDLLQVDKHQDGSITQTKLMHVSYVPLTDPTKTPVGTEPLSDYQVSWLNSVVYIGSLTVLPICRYISENYGRKRVGYLITVPLMICWILTLSASNFWHLLVARYLAGVGGTTSLFLTPIYVSEISGDSIRGQLGSMFMFSLKFGILLGYIIGAFLSYHLFAVCALLMCFLYFLCFNFLPETPIYLLRNETEVASTESLMWLKNNDTTAVERELSRMKIFVEKNYNAKNTVSLKDLFRDKGTIKAFIIAMTLLCGQQTCGIMIVLGYTAKIFEMAGSSLHPNICAIIIGIIQIISCWLSILLMERAGRKTLISISCIGIYHSYDVSSVNWLPLIALSAFSILYCLGMGPAPFVVMSEIFSSDISALASSIALLFMGLMGFINMKTFPFLVDLIGIHSNFFLSALVGLLTLIVITCMLPETKGRSLQSIIHELNGITEHSGVMTSSCQVLQNNHNKESRLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HT70</accession>
    <name>A0A8J2HT70_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Similar to CG1218: Histone PARylation factor 1-like (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HICCMSTLAB_LOCUS12935</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the HPF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5107821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HT70"/>
    <dbReference type="OrthoDB" id="416496at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072572">
        <property type="term" value="F:poly-ADP-D-ribose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019406">
        <property type="entry name" value="APLF_PBZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019361">
        <property type="entry name" value="HPF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13386">
        <property type="entry name" value="HISTONE PARYLATION FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13386:SF1">
        <property type="entry name" value="HISTONE PARYLATION FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10228">
        <property type="entry name" value="HPF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10283">
        <property type="entry name" value="zf-CCHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PBZ-type" evidence="7">
        <location>
            <begin position="19"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="31"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="123"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="77"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="123"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF10283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG5107821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="460" mass="52463" checksum="6A825A34EF6137D2" modified="2022-05-25" version="1">MDDNSKNTLEEFNDDPRVTCQYGASCYQKNPKHHEKYKHPPVIQQAQVVEDSAEQGKKRKVDDECESDESVSSKKFKNNEHNESEPVVDKQRISPSPSTSSDDDDFVCDEDDIERIMKEASIKKPIDNSANSDKDLNAGHSRVPASGINNVVDKKKIILDLFLVEMPDDFYKFYEFCCSLSKDDPQSALRSVDLKLVGPYDVLLDKIKTYSDNDKEKYLRHWRYYYDPPEFQTILKGNDKDGLHYGYWRDESKTQPTFIAKNSANKNYKIVPVAPNIFSAVMAHIEERQKIANPFEKGKISRVLQTLKNYAKTHDICLEKNSAGMQKRNREVITKTLHGAGIVVPYNKKTQLGYRQLSLTDSHLIKLLHQIEKADSIDVKVYLGKLEEVVRLATIAADECDFGTPLELGHDLFSCGIEAVQRIALQMLALAYNLLKRPEFLKIAEAHISHRKKGCDLSVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MBU3</accession>
    <name>A0A8J2MBU3_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Clip domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HICCMSTLAB_LOCUS2864</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001117">
        <property type="protein sequence ID" value="CAG5078868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MBU3"/>
    <dbReference type="OrthoDB" id="7692703at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1640.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022700">
        <property type="entry name" value="CLIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038565">
        <property type="entry name" value="CLIP_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12032">
        <property type="entry name" value="CLIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51888">
        <property type="entry name" value="CLIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0720">Serine protease</keyword>
    <keyword evidence="2 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035236128" description="Clip domain-containing protein" evidence="6">
        <location>
            <begin position="26"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="Clip" evidence="7">
        <location>
            <begin position="53"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG5078868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="143" mass="15807" checksum="04A4F58E30C34CB1" modified="2022-05-25" version="1" fragment="single">TELKTFTSVNLVLFVVCLYSGHVALNGTCDNDCTDIIICDVPLQLNENERNFDCTSPTGLQGLCINIADCPPLVRLIKMVPLYQKDVAYLRMSQCGKSSDNKPKIMILSIITSNMKYPPRSRSEISGSQLNTAFAEKKCPRAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MFL5</accession>
    <name>A0A8J2MFL5_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cc_17a_2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS4821</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5088386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MFL5"/>
    <dbReference type="OrthoDB" id="7684497at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="111"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="180"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="111"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="180"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="204"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5088386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="232" mass="25260" checksum="31554B82DB4621D2" modified="2022-05-25" version="1">MEFFTNPFQGLIVAETQPGQPIKIIRDYVNLNGNVTKSYDCFKQRDYVQLPGKLIQSSKIGKETFEFVSAAKSASPSVQTTSNLAREVKQRAKQIGAQLSSFNDRSLSVVDSDDSTSLSTLQSSNGSMEVDQVQKSPSVMAFNDLQSVATSNTNFKSSEADALSSAPSSFYNVNLDDNESVVSSDHNDRSNAMSGPSAVDKKTVATSFDKTSAGSPFSDNSKKNYRKYMPNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MHA8</accession>
    <name>A0A8J2MHA8_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">H15 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS3198</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5081124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MHA8"/>
    <dbReference type="OrthoDB" id="1110759at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006334">
        <property type="term" value="P:nucleosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005818">
        <property type="entry name" value="Histone_H1/H5_H15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00538">
        <property type="entry name" value="Linker_histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00526">
        <property type="entry name" value="H15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51504">
        <property type="entry name" value="H15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="H15" evidence="2">
        <location>
            <begin position="4"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="73"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="145"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="184"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="203"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5081124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="215" mass="24666" checksum="BF876C80AA278E82" modified="2022-05-25" version="1">MVKQSPKMTKLVVSAIKNLRDVQGSTTKDILNYVMKEYNSEPSLERRLRTALKRGIDYGILVKKGPHYLLNTEPEMSVAEQAPMERGGRRRKRGKKGRRGKKGGRRGRGRKRRGGKRKRGGKSRGRRRRSRRRRRGGRGKKMRKRGGDDNMDMLHKEPFEAAPVAPHGDPDAPVGPQTYDRPRSRSRSRQSRSRSRSRSSGSSDRENHDSRRQAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MHA9</accession>
    <name>A0A8J2MHA9_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">cGMP-dependent protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="26" type="ORF">HICCMSTLAB_LOCUS5365</name>
    </gene>
    <organism evidence="26 27">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="26" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.12"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cGMP subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="26">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.12" evidence="3"/>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5089757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030553">
        <property type="term" value="F:cGMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004692">
        <property type="term" value="F:cGMP-dependent protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd18602">
        <property type="entry name" value="ABC_6TM_SUR1_D2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03250">
        <property type="entry name" value="ABCC_MRP_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03244">
        <property type="entry name" value="ABCC_MRP_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd05572">
        <property type="entry name" value="STKc_cGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000838">
        <property type="entry name" value="ABC multidrug transporter (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000013">
        <property type="entry name" value="ABC transporter C family member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000997">
        <property type="entry name" value="Multidrug resistance-associated protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000210">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002374">
        <property type="entry name" value="cGMP_dep_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018488">
        <property type="entry name" value="cNMP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035014">
        <property type="entry name" value="STKc_cGK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF461">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C MEMBER SUR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00104">
        <property type="entry name" value="CGMPKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="cAMP-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00888">
        <property type="entry name" value="CNMP_BINDING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00889">
        <property type="entry name" value="CNMP_BINDING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 18" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0140">cGMP</keyword>
    <keyword evidence="14" id="KW-0142">cGMP-binding</keyword>
    <keyword evidence="11" id="KW-0418">Kinase</keyword>
    <keyword evidence="15 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="10 18" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 20" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="66"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="113"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="744"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="828"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="929"/>
            <end position="951"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="963"/>
            <end position="983"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="24">
        <location>
            <begin position="1"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="23">
        <location>
            <begin position="226"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="24">
        <location>
            <begin position="703"/>
            <end position="991"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="23">
        <location>
            <begin position="1027"/>
            <end position="1261"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="22">
        <location>
            <begin position="1426"/>
            <end position="1541"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="22">
        <location>
            <begin position="1558"/>
            <end position="1670"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="21">
        <location>
            <begin position="1692"/>
            <end position="1950"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="25">
        <location>
            <begin position="1951"/>
            <end position="2001"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="552"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1389"/>
            <end position="1412"/>
        </location>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="1722"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00047298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00047462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="EMBL" id="CAG5089757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="2001" mass="224532" checksum="89D14139BDAAC6CA" modified="2022-05-25" version="1">MQLLLGKKMSRNLKSIAEKSDARLKLLNEVLQGIRLVKLRAWEVVFEKKISTSRDEELTLLDKDSIYWGFITFLTHASSVLMTLFTFGVYFWLEETHLDAGNVFASLALFSQLTVPLFIFPVIVPIILNAIISTKRLEDFLSLPEVADVVPNTRENYLENNDHRTSMVTVSSDEEKNLQSIATFGTLGNITEDDEDRQAFQVLSTYEASSSDTVFEKDPEPMKPAVLYIKGVFSLGEDTHLQVDDLVIPREKLTLIVGKTGSGKTSLISAMLGEIPQLRGQVSWSRDTHLAYVPQRPWLLNTSLRENIVFGSMYSRTRYRNVLKACALQPDVEILPGKDMTRIGEKGINLSGGQKQRIAIARAIYSDADTVIFDDPLSALDQQVGQHIFDQAIQKLLLRKGRTVIMVTHRLELLRAAHHVVSMENCQVRAMGTMSSIELTDPQLVEEWREAARRRLDISVQDQTVPKTAKDRWSLVRLVSRIAGISVKHRHASDGSWITDQDAHVSPPAFVPLRLRKSMMLGSRYLAHDLTDLPVADEWGVVRKRTRKHRMASRATSLQPAKHPPPVLRQSSTPTMLETHHIIPRKRHHTVDSGQNSVLRQFFSGRILAADEVNKDRKGLKRLMSTSSSKTNPEWEYYTENKSIRRLLSTESGISENLEEEKCTECQELPEVTGIEEDGGLVTTKVWLNYLKAGGITPGLTYLAAALGCQALRVYTDLWLSEWTALGKNPPKSEITISTHQQTVFYFQMYIILSVSSIILAALNSAAGQWAGTRAREKLHRKAIATVLRAPMIFFEHTPIGRILNRFSADVGVIDKKISTSFQRLTSFALLCGSAIIVNIAISPWFLLAAVPTCLVYFFLQRFYRVSARELQRLEGSTRGPVAAHFSETLTGLPVLRASKQQDRFMDDMIECLDANTNAFLILNTSSRWLGIALDYLGAVVVIASIFAALLSAELYPERVTPALVGLAINYTFLVPIYLNWVVKFISEIEMYMGSVARISAYIKTGRENYRENGYVAEESWPEKGEIIFENVSLRYHSDCDAVVNNLNLRIPAGQKLGICGRTASGKSSTVMALFQLLEVSRGRIIIDGIDIKRVSLASLRSRLSAIPQDVIMFSGTVRENLDPLSEHDDEQLWIALELAQMKDVIASHPEGLNLEVREGGENFSSGQLQLLSMARATLRDSAVVVLDEATSALDSSTEKNLLQAVSKTFKDKTVITIAHRVTSLLYCDRVIVFHEGKIVEEGSPKELFLRSTGFFAEIVETLSRTQARRVSNNVTESEDKMRFSCFPRATILGQKGSINLTTVPGHEDSSSVTGISIISNNGDAREPIPMSYKRAADLDSTEIISHYANPTSNGSAHPNIEARGFEMVNLVRSNTAESNLSVQAKIPRGGVIGRTPTPPSAPTPVYEKDPRSRKQIKRAILENEFLGNLEEAQVEALVSAMYPKNIPPSTLVIHEGDIGSHLYVSADGEFDIYEGSKFQSSFGPGVAFGELALLYNTKRLRSISVKKGGKVWVLDRSVFLTVMMRSAQDRLEGNLRILRKVSVLQKLPEPKEHVFAKISDLIRVEFFPAGAKIVKQGEKGDKFFIISGGNVRITQDTEYGGEEELVVLGKGQYFGEKALYDKEDNRRQANAIALAPGVECLTLDGTSFLNYLGGLDEIRNKDWLAEYEKQKRSLTPKLWTNEYSEVTLYDLESRGTLGVGGFGRVELVTLRADQNKSFALKKLKKKTMVDQQQQEHVLNEKCIMQACDSPFICKLYQTYKDSKYVYFLMELCLGGDVWTTLQRRRYFDDTTAQFMVGCVVEALDHLHSLNIVYRDLKPENLMLDSRGYLKLVDFGFSKKIGPDKTWTFAGTPEYVAPEIILNKGHDRAVDYWALGILTHELLVGKPPFRGSDHMTTYNKILKGIEVVGIPSIVNKNANHLIRKLLRLSPSERLGYLRNGIQDIRDHKWFANFNWPALQRLALPAPIVPTIQSQTDTRNFERYPPDREIPPDEFSGWDMDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MHJ4</accession>
    <name>A0A8J2MHJ4_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS6242</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5092590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MHJ4"/>
    <dbReference type="OrthoDB" id="6657230at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5092590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="290" mass="32416" checksum="B02AE9CD0A15E66F" modified="2022-05-25" version="1">MSQSEQSVSGIYDKDMSTSKNSSTLRLNQEGAVGQERDWMDHDTDSEISEHDFLTKGAFLLTPSHELTVEKAATICDKMNFRGAFSLTKTATGILFKFSNIDDFQAVYKKGFHKVTGARFYKKVAIPCRPAKIFTVYVLDVPEELPEDDIRHALYKYRSIVEVTRLPLNTATVLKAINDKLKSENSNEPPTIYTGPPVIRVTLASVEETSMLLSRGLDFYGATFFPTETPHPISANLAKYKNNSCSNDRWLELASLGAGQRVRDLLPVFDNAGFTKLPPPASRVIKPQRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MIU8</accession>
    <name>A0A8J2MIU8_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Similar to TRAIP: E3 ubiquitin-protein ligase TRAIP (Homo sapiens)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HICCMSTLAB_LOCUS3944</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5083838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MIU8"/>
    <dbReference type="OrthoDB" id="8062037at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090734">
        <property type="term" value="C:site of DNA damage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031297">
        <property type="term" value="P:replication fork processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052639">
        <property type="entry name" value="TRAIP_ubiq-protein_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46569:SF1">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RFWD3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46569">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE TRAIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="1 3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="5"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="290"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="338"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="92"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="212"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="290"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAG5083838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="426" mass="48947" checksum="B4FA86F77812E607" modified="2022-05-25" version="1">MHVSCPICVSRIESGDDIVSTNCGHVFHYPCLTQWLERSKSCPQCREKTSSSRIHRLYFNVPNSESIRDDPVLLQERVDNMQFQVMLKDKEISNLKDESHKYKIQAAGLRKEVLKLESDVEQKKNTIGALKEQAKHFKAASDEAKKFKEQAELYKTKLDDIKDVQMVLLSTDKEVNDIVTSTDERKLSIYVSALKKELTKCTENRRYHREQIRKLRDDLMKANGEIDRLREQSRKTQSIEEVIITLEAENQALKNRLEEVLNSQNLETSGAETKRDDKTYTKSNLQENVLTAKDTNATNRHNEKKRSGVRDEEDLTGINPRYKVQNIVPDMKRKLSSMNTASNLPGSSILAKKPRPAYDPMALTRPRDDTYISDGLGGYKKYEEFPTSNKTGMKKKFVRSNSASGRNSKSQKDLLNFKIDNFVDLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MJ19</accession>
    <name>A0A8J2MJ19_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS4129</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5084531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MJ19"/>
    <dbReference type="OrthoDB" id="10643781at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="135"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="135"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="151"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5084531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="230" mass="26701" checksum="25DCDE9F40079731" modified="2022-05-25" version="1">MDDTIVTPTPENIVNHDELILQQQWNIEKEMSKLILHIGEEKSLKVLEREYPEEQVYCLKDSRWFILCGLICRLPLCRCLIRRPTLIIMTSMIHLCSHFGFWKLTSQNPPELLIARNEQAISDRKRLAKSYQVQDQQHLDQSSANFPAEESSSNSYGDSSRTVTSSMFSRKYVQPSEILSDFFFADDEAPGSQEPNLNLENRKFVVKNEQDLDHILIDKDQGLDLVIYVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MJ95</accession>
    <name>A0A8J2MJ95_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Mitochondrial (Mus musculus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HICCMSTLAB_LOCUS4358</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5085375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MJ95"/>
    <dbReference type="OrthoDB" id="10003563at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097250">
        <property type="term" value="P:mitochondrial respirasome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1320">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007667">
        <property type="entry name" value="Hypoxia_induced_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050355">
        <property type="entry name" value="RCF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12297:SF3">
        <property type="entry name" value="HIG1 DOMAIN FAMILY MEMBER 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12297">
        <property type="entry name" value="HYPOXIA-INDUCBILE GENE 1 HIG1 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04588">
        <property type="entry name" value="HIG_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51503">
        <property type="entry name" value="HIG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="63"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="HIG1" evidence="7">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51503"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG5085375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="102" mass="11463" checksum="6AB480CBD8EEC941" modified="2022-05-25" version="1">MDRRREIIIDETPMQQMWRSFSGNPFLMIGVTGFIATAIIGGYRFAKRPKDSPPSLFLIQLRVTAQSVVVGSLGIGMLYGMVDHWILNPKPKRKAIADAENK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MJI4</accession>
    <name>A0A8J2MJI4_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phosphatidylinositol-specific phospholipase C X domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS7788</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5095597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MJI4"/>
    <dbReference type="OrthoDB" id="1046782at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08557">
        <property type="entry name" value="PI-PLCc_bacteria_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051057">
        <property type="entry name" value="PI-PLC_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13593">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13593:SF113">
        <property type="entry name" value="SI:DKEY-266F7.9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035208468" description="Phosphatidylinositol-specific phospholipase C X domain-containing protein" evidence="1">
        <location>
            <begin position="25"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5095597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="299" mass="34493" checksum="82FDDE3D161572A7" modified="2022-05-25" version="1">MSREIVFLLIVLYCIIIDKYLVQACGCATYVYKPYLEKTKLLGKLPETKKLHSLALVGTHLSASYTTQDETLRTQDLTILQQLKYGVRGFDISVCPQSTHFELYPYPVMKGYNFYNILFEINKFLDENPGEFVIMLIKQSDYCDYLGSIKSNCEIIEEYIFNVWGGWRMFRSRDPSFAECSLDINSHCLTHKLQTSMGRKLHQIFFLTSIIVRKIKIANRKCNENFRCSIRDTTFLNQYLNRQTLARDGGFSSGDECGEPINLLMTNNFENLNCGLIIVIADFGTQDLIDKINDGNFKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MJJ2</accession>
    <name>A0A8J2MJJ2_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similar to T: Transposable element P transposase (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS2731</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001117">
        <property type="protein sequence ID" value="CAG5078413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MJJ2"/>
    <dbReference type="OrthoDB" id="7695767at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048366">
        <property type="entry name" value="TNP-like_GBD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21788">
        <property type="entry name" value="TNP-like_GBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transposable element P transposase-like GTP-binding insertion" evidence="1">
        <location>
            <begin position="51"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF21788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5078413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="208" mass="24398" checksum="A473975DFA3A3510" modified="2022-05-25" version="1">MGYPQNFAVVMDGASWNRGVWKIFGVNENNISCEHPYDSSRRLWMISDFHHLVKCFRTSTLDDKLHEFKTPFGTVKKRHWEALLEEENYRQPNLKIAYKLTPAHLKPKGFQAMNVPLATEVFGHEVSVAMAHYQSTCDELKDSTPTQNFIDLVFNLIQAMSSRIPRDALYVKEDCRQRQVRLVMKTKNNQKLKNSRFLWKNITRLSFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MJV3</accession>
    <name>A0A8J2MJV3_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS5670</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5090536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MJV3"/>
    <dbReference type="OrthoDB" id="10629277at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5090536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="157" mass="17971" checksum="D2E91390BD21F8C7" modified="2022-05-25" version="1">MAESERKLKSIEAGIDPSRRNKKNLFSKSLMSEAAEKFEQEAITMKFYLKQMSMELQKRKNNFEAPSDDESSTESESSDQENEDKNPTIKRKSSEKIEIGIPKTIKILSDEVIAKTVKPNAENGLDVAIQDETKKFKMISIPRNKLIICKQEKQKLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MK29</accession>
    <name>A0A8J2MK29_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Similar to STX17: Syntaxin-17 (Homo sapiens)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HICCMSTLAB_LOCUS3214</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5081189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MK29"/>
    <dbReference type="OrthoDB" id="10035606at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000421">
        <property type="term" value="C:autophagosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048278">
        <property type="term" value="P:vesicle docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006906">
        <property type="term" value="P:vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059001">
        <property type="entry name" value="STX17_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045242">
        <property type="entry name" value="Syntaxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957">
        <property type="entry name" value="SYNTAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957:SF139">
        <property type="entry name" value="SYNTAXIN-17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26585">
        <property type="entry name" value="STX17_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="172"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="198"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="3">
        <location>
            <begin position="117"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="231"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="234"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG5081189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="250" mass="28482" checksum="18D3BDC66603970E" modified="2022-05-25" version="1">MNISTAKKMSESSTIKQPIRRLEIPISKFDVAIPHHLDLLRRHKNNIKNYQRDKDWAKVHKEQTNALRLVKQLEQLLYEMDTLRGQQSQPLDERFLQLQTEQDEIERQNACLHAWNSLQNDLQQLHQLFVHMNQLIYDQKHHVNEVEDNVVESHENVVRGNKFLEKASKLKVAAYPLAGALIGTCIGGPVGLIAGVKLGGLTALGCGILGFTGATILKKKHLEKLENVEGPLQIKDKEDQTPELDQKKEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MK36</accession>
    <name>A0A8J2MK36_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to MTARC2: Mitochondrial amidoxime reducing component 2 (Bos taurus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS3230</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5081253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MK36"/>
    <dbReference type="OrthoDB" id="17255at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030151">
        <property type="term" value="F:molybdenum ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005302">
        <property type="entry name" value="MoCF_Sase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005303">
        <property type="entry name" value="MOCOS_middle"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011037">
        <property type="entry name" value="Pyrv_Knase-like_insert_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14237:SF19">
        <property type="entry name" value="MITOCHONDRIAL AMIDOXIME REDUCING COMPONENT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14237">
        <property type="entry name" value="MOLYBDOPTERIN COFACTOR SULFURASE MOSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03473">
        <property type="entry name" value="MOSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03476">
        <property type="entry name" value="MOSC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141673">
        <property type="entry name" value="MOSC N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50800">
        <property type="entry name" value="PK beta-barrel domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51340">
        <property type="entry name" value="MOSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="domain" description="MOSC" evidence="2">
        <location>
            <begin position="177"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5081253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="351" mass="39370" checksum="10E58A2BB02BDE92" modified="2022-05-25" version="1">MSQLSNKKIILTDRTRMSCITALAIGTTTLLVFAWWWWRRGKVYILPRNWRKVGELSDIFVFPVKSLGCIRETAIECTPLGCKSGWLRDRTLMVIDLSGKFVTGRQLPRMVQVIPNVAGSVLTLRAPGMMTISIDLAQIGSKTFKAAVWSQSVPACDCGEEVARWLSRFLLQEDTGLRLVYYPLDGPYRDVRENNRGFPLMEKSDAGAYPDATAYTLMNEASINDLNTRIEDAVVPLNFRPNFVVKGAEPLEEDTWDWIKIGGVLFRNVKPCTRCIFTTVHPELGVKHPKMEPLKTLKTYRLIEDPDLRPYTKDNPVMGVHMGLKGPNGVVRIGDPVYVGIADADPVTSPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MKT1</accession>
    <name>A0A8J2MKT1_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Similar to Pla2g12a: Group XIIA secretory phospholipase A2 (Mus musculus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HICCMSTLAB_LOCUS5985</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5092222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MKT1"/>
    <dbReference type="OrthoDB" id="3935740at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004623">
        <property type="term" value="F:phospholipase A2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050482">
        <property type="term" value="P:arachidonate secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006644">
        <property type="term" value="P:phospholipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00084">
        <property type="entry name" value="HMG-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.90.10">
        <property type="entry name" value="Phospholipase A2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010711">
        <property type="entry name" value="PLA2G12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036444">
        <property type="entry name" value="PLipase_A2_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12824">
        <property type="entry name" value="GROUP XII SECRETORY PHOSPHOLIPASE A2 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12824:SF8">
        <property type="entry name" value="GXIVSPLA2, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06951">
        <property type="entry name" value="PLA2G12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48619">
        <property type="entry name" value="Phospholipase A2, PLA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HMG box" evidence="3">
        <location>
            <begin position="236"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="1">
        <location>
            <begin position="236"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="183"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="270"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="199"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="288"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG5092222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="304" mass="34419" checksum="009B7FED7638F582" modified="2022-05-25" version="1" fragment="single">MDFMRYRKFFVYILTFLAYAWSGYGAGLIGNLRDAVLAAETIFGDFFQNAITVARKIKDIHEVFDAAVEEHCVYTCPNGVTAKPDRNHVPQSNGCGSLGIECCDEHDICYDTCNSDKEKCDLEFKRCLYKYCEGYQTTGTTIVNTCKAAAKMLYTGTTTLGCKSYIDAQSAACWCPEKDKSRSWKKKGKWSGMGNENSTPKKSETRKFRGDFKSTDGDSSKTSEPKRPRKQKAKSSGGPTNPFLIFFLRMRSKKPNEHVTTIAKAAGRQWAKMTPDQRQKYVKMASVAKKKRVYKKKKREDDPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MLC5</accession>
    <name>A0A8J2MLC5_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">EB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS6986</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5093656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MLC5"/>
    <dbReference type="OrthoDB" id="504708at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006149">
        <property type="entry name" value="EB_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39069">
        <property type="entry name" value="ECDYSONE-INDUCIBLE GENE E1, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39069:SF8">
        <property type="entry name" value="FI17111P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01683">
        <property type="entry name" value="EB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EB" evidence="1">
        <location>
            <begin position="169"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5093656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="376" mass="40543" checksum="CAE97DAB4CF8A7EC" modified="2022-05-25" version="1" fragment="single">TLGGSCKSAYDCDKIKFSKCSENNKCVCEAGFIAFDSSTCSSPQLSGSCTSDNDCNYVMHAKCGGNNKCVCRANNVAVNERCLPIVNGFCWKNETCATKNSICIDSTCHCNPGFKFSPQINECRQPYIGKPCEVNSDCDEIVNGECSNDKRCTCKKNSIILDEFTCGPKLGGACSDDEECLSENSKCEDNICACKTGFSAVNTFDCLVATKLGMPCNSKANCKQLYNSDCIQGHCVCPSNTFAINQTACLSLIGGSCLSHDDCRPAYSVCNSSRCECQFEYVPASSNQCIFGSSAVDCRSNADCGDQMRRECSTYNKCVCKSNSVALGTYECKSIVGGYCAEDTDCAIINSVCVNNTCQCKFTLKPISHNLCPTNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MME2</accession>
    <name>A0A8J2MME2_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">carbonic anhydrase</fullName>
            <ecNumber evidence="2">4.2.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HICCMSTLAB_LOCUS7954</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>hydrogencarbonate + H(+) = CO2 + H2O</text>
            <dbReference type="Rhea" id="RHEA:10748"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="EC" id="4.2.1.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the alpha-carbonic anhydrase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.1" evidence="2"/>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5095930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MME2"/>
    <dbReference type="OrthoDB" id="429145at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004089">
        <property type="term" value="F:carbonate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00326">
        <property type="entry name" value="alpha_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.200.10">
        <property type="entry name" value="Alpha carbonic anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001148">
        <property type="entry name" value="CA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036398">
        <property type="entry name" value="CA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023561">
        <property type="entry name" value="Carbonic_anhydrase_a-class"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18952">
        <property type="entry name" value="CARBONIC ANHYDRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18952:SF265">
        <property type="entry name" value="CARBONIC ANHYDRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00194">
        <property type="entry name" value="Carb_anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01057">
        <property type="entry name" value="Carb_anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51069">
        <property type="entry name" value="Carbonic anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51144">
        <property type="entry name" value="ALPHA_CA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035308790" description="carbonic anhydrase" evidence="7">
        <location>
            <begin position="21"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-carbonic anhydrase" evidence="8">
        <location>
            <begin position="19"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAG5095930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="273" mass="31083" checksum="480E0BE8C9299E48" modified="2022-05-25" version="1">MNLGKRHIFFFAHLIHLISAWEYKDVGLWENEYPSCGGAQQSPINLDDIEQSDNSEGKITFKRYNITPKKMMIKNNGHTVEIKPKWDGPSNRKPRVIKNGTEYEVVQLHYHWGSSNDSGSEHVFNKVSTSLEVHVVHWNPDYGSFDPEQGEGILVIGNLYITDDRYGAEYLDGVISSFPSIVEPDSEPVEIEPFSLSKILTESWADAYLTYTGSLTTPPCSEGVSWVILNYPSIVDSRQMEAFRTIKFAHGDDHNNRPIQSSNSRQITRVLRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MMJ3</accession>
    <name>A0A8J2MMJ3_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Similar to nrf-6: Nose resistant to fluoxetine protein 6 (Caenorhabditis elegans)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HICCMSTLAB_LOCUS7472</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5094964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MMJ3"/>
    <dbReference type="OrthoDB" id="207378at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002656">
        <property type="entry name" value="Acyl_transf_3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006621">
        <property type="entry name" value="Nose-resist-to-fluoxetine_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052728">
        <property type="entry name" value="O2_lipid_transport_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11161:SF72">
        <property type="entry name" value="FI21449P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11161">
        <property type="entry name" value="O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01757">
        <property type="entry name" value="Acyl_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20146">
        <property type="entry name" value="NRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00703">
        <property type="entry name" value="NRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035179563" evidence="3">
        <location>
            <begin position="19"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="265"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="417"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="455"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="490"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="573"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="600"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="643"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="673"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="713"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="744"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="778"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="domain" description="Nose resistant-to-fluoxetine protein N-terminal" evidence="4">
        <location>
            <begin position="96"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="325"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="327"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="365"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAG5094964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="819" mass="92407" checksum="04C1EB0783545557" modified="2022-05-25" version="1">MNNLTWFILILSAIKIFADDSLSTAETVVVPEVHTFRIASSKYRSDSSEVDSESNNDSNDDNEDDNMNWHTLAENLDFYNTKTLVKNWKENEYPVNPQCAKDITRFVKGLRNQEPWALKADDASGRFTNGFFWGNSYFIGSATECTYIGYNYTKANDKFATSGSHSSEPKKKNVGFSGSQLFSNSLPDHPPYKLGFFTLTILVNNTIITPVSRSIQLGVCLPFSCTAEDIFIIARLAANEDAKKHFAIEKVRDQHNQYDIYSDNVFWTLVGSSVIVIILMIIGTILDYYITFTATRQQETTIYDLEKHVQLRHSIKLHQELSNDGLDSATTTSTNSCSSNDNNNNNDIDDEEETVERKNKMKNHNPLNNTPSSVSSANDEELSVIKELLLSFSVRENMKTICDSSVGRDTISTIHGLRAISMAWVILGHTCIVIFKYSDNMEYRKVVEKNFLFQTITSGAFSVDTFFFMGGLLVAYLFFRTNAMGDLNKLTQGTHGFVAGLLKFIGLLLYRFSRLTTPYMFILGVVQVTMKWFHANSVFEPPTNDHENCPNYWWRNLLYINTLFPVDQMCMLWSWYVADDTQFYVIGAVILVIATNHIKVATVFVVALLVSSWLTTGYIALINNHMPSIDDPLALFDKIYDKPWTRMGPYLIGMSVGYILFKTDCKIKMSKATVVVGWLLSIACLLSLIYGLYEAELTPVTAAAYSSLSHSAWALGLSWIIIACSTGYGGWVNEILSAPILYPFSRVTYCAYLVHPIIIRVSAMHLDLPFHLGKDTVVIVFIGQLILSYLISFVVSLCFEAPVVSMLKILSPKKKKRIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MNM6</accession>
    <name>A0A8J2MNM6_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS8589</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5097201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MNM6"/>
    <dbReference type="OrthoDB" id="7683176at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035273985" evidence="2">
        <location>
            <begin position="23"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="180"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="230"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="287"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="533"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="598"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="737"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="192"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="230"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="325"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="336"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="609"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="628"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="641"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="756"/>
            <end position="766"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5097201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="766" mass="81730" checksum="A4C3BD129B59426A" modified="2022-05-25" version="1">MNWLKFKWVFLLVTVNVLLVKAVPANISRTREKDQRTGSKYVEIKLPVKITSMEDLVAWVKNAMQTMASRIDITLAADSSAVADQKNSESKPQVSQVSESKMVLKPKEETEKLPITRSLPVPGFENPWFPYGNDVFPPVINADAYLPLFVGDLGSRYALPTAGFDIRKNFFQNIRQEVTTTTSTTTPAPRAVKIESRSSTERNDSNNGDSGAIPFAIPFEAFITITRDEETVQKEDSDEHEESNAKKEVEVSTNIKNDGKKKESARKRQIAVLGDLLEALGLTRRPDKNKIEGAATTTAGTKSKRPREEPLRPPIAFGEVPPRPSSEDSFQRQEFENELDDDDEEEDGGSLGSVADLLPLALPILEDLSDPESDADLIEILQAGVPILAGLSEPDEDGNGGAKELIDMIVPVVTKIINGPDGQGIDLGALIGPIFSLLAPFIGPVLAPVIGPLVRSISNPPTEGSSLGALLAAITGPLSTPQEPSGMSPLAIVIAGTAAALLRELKPGLPGGLDVGALVGAVLTGVISGTSAGLSGGSSDSNAPHDQAQPYGANLQRPASSINDNVIFPGRPSPGPPLNSPFIIRRPNNQAATVNIGSTARPYVPPPQYQQYQHQQPPGQYPQNQQPTSNYPQYQQSASNYPQHQQYRPQYQQFAAPSRPASQTQQFRPGPTPPSPYPYNQHTGLVPAAANNNGNYGVPANTVNPLSLIGNTVKELLGGGISLVSTVINAVFGVVGASSASSDSPPAPSYGPPTGHYTQASEEIDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MQK2</accession>
    <name>A0A8J2MQK2_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Similar to UTP23: rRNA-processing protein UTP23 homolog (Homo sapiens)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HICCMSTLAB_LOCUS10693</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in rRNA-processing and ribosome biogenesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the UTP23/FCF1 family. UTP23 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5101794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MQK2"/>
    <dbReference type="OrthoDB" id="25675at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006984">
        <property type="entry name" value="Fcf1/UTP23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057776">
        <property type="entry name" value="UTP23_sensor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12416">
        <property type="entry name" value="RRNA-PROCESSING PROTEIN UTP23 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04900">
        <property type="entry name" value="Fcf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24779">
        <property type="entry name" value="UTP23_sensor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="UTP23 sensor motif region" evidence="8">
        <location>
            <begin position="173"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="155"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="175"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="204"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00037300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038503"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF24779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAG5101794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="242" mass="27243" checksum="37585FB07DF0B17C" modified="2022-05-25" version="1">MKVKRLKKAKKHLAFYINNYKFRQPYQVLVDGTFCFHALANKTNIREQIPKYLQGEVKLLTTSCIAKEVENLGHKFYGALTILKNFPLHKYIVATQDATLQGKLKLIPGVPTMYLHGPAPILAPPSEEDKGSAEFSNQVSVKNAEVERLKELKESMAKKGLLPQTPQPSQEFTKVKRKKGPNPLSCKKKQKKPTLTQPAPSSGKVRKRQRVKVSAHIKEALKQVLLVKKSLGSHRQHLHALG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MRU0</accession>
    <name>A0A8J2MRU0_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Similar to ubl4a: Ubiquitin-like protein 4A (Danio rerio)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HICCMSTLAB_LOCUS12024</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5104482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MRU0"/>
    <dbReference type="OrthoDB" id="417450at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071818">
        <property type="term" value="C:BAT3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006620">
        <property type="term" value="P:post-translational protein targeting to endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071816">
        <property type="term" value="P:tail-anchored membrane protein insertion into ER membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041421">
        <property type="entry name" value="Ubl4_C_TUGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047154">
        <property type="entry name" value="UBL4A-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46555">
        <property type="entry name" value="UBIQUITIN-LIKE PROTEIN 4A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46555:SF1">
        <property type="entry name" value="UBIQUITIN-LIKE PROTEIN 4A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17840">
        <property type="entry name" value="Tugs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="3">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG5104482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="150" mass="16747" checksum="FBED9CD7C187FB21" modified="2022-05-25" version="1">MKILVKILQGRECVVEISPSETVLELKNKVSELLGVDVPQQKLLLTGKALADENPLSFYPGIKDGSKLNLVVRKTTQESSDEKSPAVQKYGTALLRESVSKILKKYYSQAETESITNELVKELRTKVNNLSFDDLERLATALLQDQENIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MS70</accession>
    <name>A0A8J2MS70_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS8951</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5097935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MS70"/>
    <dbReference type="OrthoDB" id="7408822at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="73"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5097935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="311" mass="36138" checksum="F57C3BF992098F4A" modified="2022-05-25" version="1">MATEYCKKISAFPHKYEGAGIGSKCPSQILYARNCWSEKIEPKKDQRVSEESSSSNKILSKEDPLIVELAKCLKGIKSIINRQNQRKKDYREQEKKYLENFKSLDKDGKKKELKKYLDKLKLKKNLKLDEIISIKSVLVQTIKEDDKENVNDYLSELISNDYSKTVKSQQNSDRRKAENVINLICQIGFKKVNFSTEEGKRIIGNLLADTLDYLLIDIRSTYIIFRTRMNSESVFQKRSALQFLIDNYSKFPAGNSTLEDKFQKVNFKKSVGTLDNIINDWNNVTDSDEDSLDGESFVDKLVPKSHNWWWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MSA1</accession>
    <name>A0A8J2MSA1_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Coiled-coil domain-containing protein 86</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HICCMSTLAB_LOCUS11588</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Required for proper chromosome segregation during mitosis and error-free mitotic progression.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5103595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MSA1"/>
    <dbReference type="OrthoDB" id="277961at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026570">
        <property type="entry name" value="CCDC86"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13557">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 86"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13557:SF1">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 86"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6" id="KW-0164">Citrullination</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="30"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00093307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAG5103595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="85" mass="10355" checksum="647CB73BBFA43063" modified="2022-05-25" version="1">MPFEKKEKLREELKRVKEQSRAIKEQFQVEKEAKKERRRENLKRAEENAKKSEIVQVIKNTAKIKRMKKKQLRMIEKRDTLNSTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MSQ0</accession>
    <name>A0A8J2MSQ0_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Mutator-like transposase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS6718</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5093277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MSQ0"/>
    <dbReference type="OrthoDB" id="421276at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049012">
        <property type="entry name" value="Mutator_transp_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20700">
        <property type="entry name" value="Mutator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mutator-like transposase" evidence="1">
        <location>
            <begin position="76"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5093277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="397" mass="45540" checksum="3130A478E1D98FC9" modified="2022-05-25" version="1">MAHCVRRGENFHCFAKLDIGLNTLLSWKCLECKMITKFYTNPLKPETKFNINETASISVIGSASTFAAFQTVLAVSYRGGRHDALGASVAVIGCATGKIIDIEVLNKYCYTCRYHENRKIEPPPHKCFMNYDRKKSSSSMEPHATAVLFNRSLKLHGLIYKTMVSDDDSATLKAVRDSDPYKAFGIEVDRIKCSFHIFRSIGNKLREASKIRVPSRRVPAAVRKRIKFSGLRIRQIVTADIERLRKDLEPESLSKDEKMKIFEQNTEVLRENILLAPHHVFGNHEKCPREWSCDTSKPNHLIKIKQYGLFARVEKIVTDLSQNSVHLLHFLNTNIIEQYHGILAKYLSGKRIQYGGADEFQDRVYMGTLDQMTSGCHLSRFYKFCRKIVPERIEKLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MTF5</accession>
    <name>A0A8J2MTF5_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS13463</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5108827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MTF5"/>
    <dbReference type="OrthoDB" id="8034296at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="158"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="167"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="180"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="197"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5108827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="366" mass="40803" checksum="653ECE19656A3579" modified="2022-05-25" version="1">MEEVALAAGNGEFASPGNHTSKNANGNIITLTLKNNHIIVETEERAMAMSDNSFVVEVQPKYLKDDVDINTGSIDDITGRVTDQQALVHREEIPEDRSLASRGSVNHSYRYGNQMEYDAAQLGYMYEGSNYMNDLVSRDLEGVSKWVEFDKSPDTEKTLLNECDNSNLDKDNNEYKKLNNLDSSLDSNSSLEHQDSTDASNSTDTVRSNPNLQVNGATPNKLESMERKSLIGDYDKLEHSHQTCNNTKPIITGALFKDDMHEDIKLSVNDNNINNKFGNGTLLSPSELNKNLKTVCGDQKPEGSVFVPCHKRTNSIPPRLIEDTLDIDRKKGIDIYSQIKTSILPGLTPKFELLQNEVSPIDEKES</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MTG7</accession>
    <name>A0A8J2MTG7_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Similar to ZNF609: Zinc finger protein 609 (Homo sapiens)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HICCMSTLAB_LOCUS9406</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5100144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MTG7"/>
    <dbReference type="OrthoDB" id="5863628at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040010">
        <property type="entry name" value="ZN608/ZN609"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21564">
        <property type="entry name" value="BRAKELESS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21564:SF5">
        <property type="entry name" value="SCRIBBLER, ISOFORM J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="186"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="69"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="911"/>
            <end position="1001"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="101"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="116"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="130"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="171"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="263"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="308"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="321"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="338"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="373"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="383"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="450"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="475"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="524"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="588"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="631"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="690"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="711"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="725"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="738"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="771"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="787"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="912"/>
            <end position="931"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="954"/>
            <end position="970"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="989"/>
            <end position="998"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG5100144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="1038" mass="111933" checksum="3E45B694F0FAAEAE" modified="2022-05-25" version="1">MQDMSDVCVGTSVGTITEPECLGPCEPGTSVTLEGIVWHETEGGVLVVNVTWRGKTYVGTLLDCTRHDWAPPRFCDSPTSDLDARTPKGRGKRGRAAANATPGNDLSNFTETRSSVHSKLRNGGKGRRGAQGSPAASPSPAAFVPPRPDPAAKRKSRGPEEEEKSKRRAPPQTPPSGSPPASPVLYECPEPNCSKKYKNQNGLKYHQNHAHGSADDEDTKEGVTSMSENDESNIEAPSPATPVKSPVDKPESTPVRASSPPAATLPPATPTPPPRVPSPTADPPTPILADKTSIVKPGVLRFGQDDLPAPAAAATTVPPATVVPPSPRQPPVQQVSPANPPPQSPSPHPSPHPSPSPRPVPSPHLPTNIPQPINIPQPPPPSQVVQHQPQNQILQPQNLTGQPMQPGQLMSPQPQLQPQLQPAHQLPPVQHPVQAQLGQPAPAHMVHQPGLPPQQAPPQQQPGLQALNQHPGLQGLTNQLPQPGLQSTPPSGHPVQSHMQYPTVGLHPKMPQFKVKPTAALMPEQDKSKDPRSSKPQGYKKKSRKSPGGSPHPSPLEAPIIDSAREDVQSPAYSDISDDGAPVLEAESADKLKQGQEKDVKAGMQTHVPQHYGMFPYFGQPPYLVPSVQDKPGEQKPSDLTPKQDIKPLNIPQMPLMASLQNSEKEKKELSQPPPQQQSHYYNNYGTYIPSPYSYQPQPVAQPQQPQQQEMVDRMDEQKNKIKQEVQQQQQQQQQSSIKDKQHENHQILKESIEMKSQMSPYHRRKEEPVKPPQQPKPPPPSPKHQPKQEKPQDLGKSEESKNKQEGVKPTMETQGPPPPPTSQYAYIHHPSYMPPQHYGVPFDPNHSVYRGLSPMLIPGPFSGNPYLLPRFHAPEDLSRPQGGKALDLLQHHASQYYSTHKIHELQERALKSPTPKTSAASASPSSAGPAPARPPSGPPTSVAGGPGPPPGQGPQQGKQQPNNPQQQGPGDNGSGNLGKDTRSPPPQRHVHTHHHTHVGLGYPLIPGQYPAPYGAAVLASQQAAAVAASVISPFPPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MTL8</accession>
    <name>A0A8J2MTL8_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Similar to PSAP: Prosaposin (Gallus gallus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HICCMSTLAB_LOCUS13629</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5108993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MTL8"/>
    <dbReference type="OrthoDB" id="69496at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006665">
        <property type="term" value="P:sphingolipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.225.10:FF:000002">
        <property type="entry name" value="prosaposin isoform X2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.225.10">
        <property type="entry name" value="Saposin-like"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003119">
        <property type="entry name" value="SAP_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007856">
        <property type="entry name" value="SapB_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008138">
        <property type="entry name" value="SapB_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008373">
        <property type="entry name" value="Saposin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011001">
        <property type="entry name" value="Saposin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008139">
        <property type="entry name" value="SaposinB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051428">
        <property type="entry name" value="Sphingo_Act-Surfact_Prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11480:SF3">
        <property type="entry name" value="BCDNA.GH08312"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11480">
        <property type="entry name" value="SAPOSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02199">
        <property type="entry name" value="SapA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05184">
        <property type="entry name" value="SapB_1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03489">
        <property type="entry name" value="SapB_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01797">
        <property type="entry name" value="SAPOSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00162">
        <property type="entry name" value="SAPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00741">
        <property type="entry name" value="SapB"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47862">
        <property type="entry name" value="Saposin"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51110">
        <property type="entry name" value="SAP_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50015">
        <property type="entry name" value="SAP_B"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035179565" evidence="7">
        <location>
            <begin position="17"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="domain" description="Saposin A-type" evidence="9">
        <location>
            <begin position="31"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="domain" description="Saposin B-type" evidence="8">
        <location>
            <begin position="75"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="Saposin B-type" evidence="8">
        <location>
            <begin position="185"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="Saposin B-type" evidence="8">
        <location>
            <begin position="292"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="domain" description="Saposin B-type" evidence="8">
        <location>
            <begin position="444"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="domain" description="Saposin B-type" evidence="8">
        <location>
            <begin position="546"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="domain" description="Saposin B-type" evidence="8">
        <location>
            <begin position="664"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="domain" description="Saposin B-type" evidence="8">
        <location>
            <begin position="751"/>
            <end position="832"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAG5108993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="854" mass="96238" checksum="F6C2016F04A8AA38" modified="2022-05-25" version="1">MKKIFFALAAILAVSAAYVVQVAPEHEKHYHLLGEEFCTWGPGFWCKNITNAAQCGATKHCIEKQWKDMKVPEDRDSVCQICKDMVQQARDQLESNQTQEDLKAVFEGSCKLMMVKPIVEECDKLVDQFIPELVETLASQMNPSVVCSVSGLCNSARIDQLLLENEQTLKKAYKKIIPLKNDEIEPDECSKCFTIATHMEDKLKKTSKDQFVDRLLVVCGHMGSFSDACSSIVLVHYRVLYDQLQNKFNAKSICHLSGQCSSVFHQHEDESDQTPKVEIRPLSSVGIVDIGDDLPCKLCQQLVGHLKDLLVANTTETEFKQVLEGFCKQTNSFKDECVSIVDQYYPEIYQYLVNGLDSNAVCEMAGICPAPGRKLDRPIMPLLPTESASVAIEIAKERKTKKAHNLGENGAEVKKTEADEMQLPTDLLTTSLHILGMPNMDVNGQKTCALCEFVLHELQKEITETSTEAEIEEAVNSKVCDKMPDVIGHMCHEFVQTYGNAVIAMFVQKIDPTLVCPLMHLCPTQEAIKEWEQIPEEHMIKSEVEDKPSCPLCLLAVNQLYNVIKSNKTEENIISELDRLCLHLPQDLSKQCVDLVKIYSKELIDMLLADMTPQEVCVALKLCDPQKNVGPTSNYPMDKDGEIISNEIPYFSLQTSKPFFSEKETTKCVICETIMEYLEKAMSKKSTRDEIEKLVHEVCEYLPKSAAKQCDNFVNEYADLVITLLSQEVSPREICTLVNACEDKVQQIMESVSECALCQAILSSVDNLLTNPKVDDRIEEVINSACDYIPPGKHDKCVMLLEVYEQSIINLLKMNVDTKKICTKMSLCSSTDMFAMSHVDFRKNRLQLRNLNVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MTV9</accession>
    <name>A0A8J2MTV9_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">U6 snRNA-associated Sm-like protein LSm3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HICCMSTLAB_LOCUS7686</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the snRNP Sm proteins family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5095392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MTV9"/>
    <dbReference type="OrthoDB" id="29543at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120115">
        <property type="term" value="C:Lsm2-8 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01730">
        <property type="entry name" value="LSm3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000007">
        <property type="entry name" value="U6 snRNA-associated Sm-like protein LSm3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034105">
        <property type="entry name" value="Lsm3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040002">
        <property type="entry name" value="Sm-like_LSM3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13110">
        <property type="entry name" value="U6 SNRNA-ASSOCIATED SM-LIKE PROTEIN LSM3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Sm" evidence="10">
        <location>
            <begin position="15"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00067758"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAG5095392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="165" mass="19055" checksum="CA86FBCDAC03E155" modified="2022-05-25" version="1">MADEAEQILAINVKEPLDLIKLSIDERIYVKMRNERELRGRLHAYDQHLNMILGDAEETVTTVEIDEETYEEVYRTTKRNIPMLFVRGDGVILVSPPSMRAHSRLSLKITFLGLTLLWASRLKILWTRSMSCSSTEYNDARSSLNKIPALEKSLAIFFRGREKVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MUS3</accession>
    <name>A0A8J2MUS3_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS8302</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5096623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MUS3"/>
    <dbReference type="OrthoDB" id="7616539at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="130"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="8"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="27"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5096623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="656" mass="77785" checksum="C2DDCB65AC226797" modified="2022-05-25" version="1">METDEKDSEMKEKAKKEGEAVEDEEKEERRTEEEAKMAVEKEKKGAEEGETSELPKGKGRKTTAEAWKLHRANSTGDLSDIRDWMKCDGKRRGGGLADARENKVRVISKVSERKKEGLEIMITQGFSKIIERLDEKKEDRRKQFKELKTELSKIERKNAELEKKIERIEAENTAERTASNVKWKEMEGKIEESEKKMDKEMANIKEEMREIKEKMIAEVGEENGVRASTSTYVPRTEEGTRIAEIEAWKESKEKMERRNNLVIFGWNNKGKAERKEVAEFFRDELGMESIEESIEEVRQPGPDKKMLWVKMRRPEDKKKIMERKAKLKGKKIFIENDRTKKEREEQKGLKRRAWVAKNVDEWLAEEEEESELIIGGDWNVRIGREASVEEINNREKRWSEDTVVNRERMGWIVLNGNKGVKEEGRWTFARGDCRTVVDYGVTNAKTWNEIKSIEIGYRLDSDHQPVLVELEGTRESINKRKQKRREETKWVQSWKEEDVYKFEKGEEETVWKETEGEDKWKELKRRVDECCVKRKVRVGEKGKEGWYDEQCRKLKKKLQKGGRKKRYAVTMRKLRTKYRDLKKRKRIRWEEKMEKELKEIKTESDAWEFIRKDMRIRSEITNAFRIEAPPGFYNTVPGTGTRAELNIYRERESGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MWP4</accession>
    <name>A0A8J2MWP4_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS10630</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5101728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MWP4"/>
    <dbReference type="OrthoDB" id="6604226at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5101728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="63" mass="7134" checksum="FB21A8855F3F75DC" modified="2022-05-25" version="1">MVFTGVASADRLTVSQWMSGWEDHYDSGMKNLVTTAMIKTMQPLEIRASVVACLFLLLRPLFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-10-16" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>S6CWN0</accession>
    <name>S6CWN0_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Chitin synthase-like protein CHITS</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">Similar to chs-2: Chitin synthase chs-2 (Caenorhabditis elegans)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">chitS</name>
        <name evidence="4" type="ORF">HICCMSTLAB_LOCUS6252</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2013" name="Philos. Trans. R. Soc. Lond., B, Biol. Sci." volume="368" first="20130047" last="20130047">
            <title>Functional endogenous viral elements in the genome of the parasitoid wasp Cotesia congregata: insights into the evolutionary dynamics of bracoviruses.</title>
            <authorList>
                <person name="Bezier A."/>
                <person name="Louis F."/>
                <person name="Jancek S."/>
                <person name="Periquet G."/>
                <person name="Theze J."/>
                <person name="Gyapay G."/>
                <person name="Musset K."/>
                <person name="Lesobre J."/>
                <person name="Lenoble P."/>
                <person name="Dupuy C."/>
                <person name="Gundersen-Rindal D."/>
                <person name="Herniou E.A.Drezen.J.M."/>
            </authorList>
            <dbReference type="PubMed" id="23938757"/>
            <dbReference type="DOI" id="10.1098/rstb.2013.0047"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5092610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="HF586475">
        <property type="protein sequence ID" value="CCQ71310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S6CWN0"/>
    <dbReference type="OrthoDB" id="370884at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055120">
        <property type="entry name" value="Chs-1/2_IV_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23000">
        <property type="entry name" value="ChitinSynthase_IV_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="65"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="126"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="160"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="188"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="220"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="252"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="296"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="372"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="412"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="472"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin synthase chs-1/2 N-terminal putative transporter" evidence="3">
        <location>
            <begin position="59"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG5092610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCQ71310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="547" mass="63955" checksum="33362D77C532CB2B" modified="2013-10-16" version="1">MPDHHQPDDETLSDYKTEDNFSDNDELPLTNEPLSISIVDRINKSLKTFPMPSSFKKFTSKLWKLVSFLLFIMYVMLFMISCIVSKSTLLSMTSQLEPNHTAYCRKRQGSFEMMRLELVQSEEERIMWIWCLLLAFAVPELVNSVVCFRKSKSRPSICQFLQVMGPETLHVVGIAVMIFVILPEIDMMRFWLLCIWFIFDMGLLNLLTRVYNNAKSKRNTALIVLDCIILANLAIINIVFSLHESTFYDHSFWAIMLASICIFFGFWQDTSYSILSPTGYIQIFNSAREKLFPARHFTFALISIWKIVVFFASALTILYLNGDNIVHIFTKLGQTFGEHNLTLIEDFNKREVYYNGTIVSLETIISIKNGKFIFTISILLTQILLSILSNVEDDKGGLRMLHGFDFRSRLGWNIPLSFSFGLVIWTFYVLEPFCKLNHDMIIPRYLSFDSRERGLKKELDFHNNTLSETWKVIGSIVSVLWIGIHTIIRYYKIMVENKKPQNFEYDRPLFNRWLSSLRAHKDESIDVEKELMTFQRHQEIHLDTLFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-04-13" modified="2025-06-18" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>S6D9M0</accession>
    <name>S6D9M0_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 13">Histone H4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">histone h4</name>
        <name evidence="16" type="ORF">HICCMSTLAB_LOCUS6251</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2013" name="Philos. Trans. R. Soc. Lond., B, Biol. Sci." volume="368" first="20130047" last="20130047">
            <title>Functional endogenous viral elements in the genome of the parasitoid wasp Cotesia congregata: insights into the evolutionary dynamics of bracoviruses.</title>
            <authorList>
                <person name="Bezier A."/>
                <person name="Louis F."/>
                <person name="Jancek S."/>
                <person name="Periquet G."/>
                <person name="Theze J."/>
                <person name="Gyapay G."/>
                <person name="Musset K."/>
                <person name="Lesobre J."/>
                <person name="Lenoble P."/>
                <person name="Dupuy C."/>
                <person name="Gundersen-Rindal D."/>
                <person name="Herniou E.A.Drezen.J.M."/>
            </authorList>
            <dbReference type="PubMed" id="23938757"/>
            <dbReference type="DOI" id="10.1098/rstb.2013.0047"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="1 13">Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5 13">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 13">Belongs to the histone H4 family.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5092608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="HF586475">
        <property type="protein sequence ID" value="CCQ71309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="S6D9M0"/>
    <dbReference type="SMR" id="S6D9M0"/>
    <dbReference type="OrthoDB" id="5777208at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22912">
        <property type="entry name" value="HFD_H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000012">
        <property type="entry name" value="Histone H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035425">
        <property type="entry name" value="CENP-T/H4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001951">
        <property type="entry name" value="Histone_H4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019809">
        <property type="entry name" value="Histone_H4_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004823">
        <property type="entry name" value="TAF_TATA-bd_Histone-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10484">
        <property type="entry name" value="HISTONE H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15511">
        <property type="entry name" value="CENP-T_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00623">
        <property type="entry name" value="HISTONEH4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00417">
        <property type="entry name" value="H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00803">
        <property type="entry name" value="TAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00047">
        <property type="entry name" value="HISTONE_H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0007">Acetylation</keyword>
    <keyword evidence="7 13" id="KW-0158">Chromosome</keyword>
    <keyword evidence="10 13" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-0488">Methylation</keyword>
    <keyword evidence="12 13" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="11 13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TATA box binding protein associated factor (TAF) histone-like fold" evidence="15">
        <location>
            <begin position="80"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="21"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="14">
        <location>
            <begin position="57"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00020836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CAG5092608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CCQ71309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="155" mass="16884" checksum="BE0C97DD7436B218" modified="2016-04-13" version="1">MIDRPEGAKEGKGSSKVGKGQGKEKKGLEKGGKELEKGGKVSEKGGKGLEKGEKGSVKGGKGLGKGGAKRHRRSLRDNIQGITKPAIRRLARRGGVKRVSGLVYEEIRDVLKIFLKTVIHDAFHYTEHAKRKTVTSMDIVYALKRQGRKIYGFGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2E370</accession>
    <name>A0A8J2E370_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similar to TNXB: Tenascin-X (Homo sapiens)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS1787</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001116">
        <property type="protein sequence ID" value="CAG5075642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2E370"/>
    <dbReference type="OrthoDB" id="504708at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39069">
        <property type="entry name" value="ECDYSONE-INDUCIBLE GENE E1, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39069:SF8">
        <property type="entry name" value="FI17111P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="14"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EGF-like" evidence="1">
        <location>
            <begin position="128"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="1">
        <location>
            <begin position="168"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="1">
        <location>
            <begin position="402"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="1">
        <location>
            <begin position="483"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="1">
        <location>
            <begin position="564"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="1">
        <location>
            <begin position="605"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="1">
        <location>
            <begin position="646"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="1">
        <location>
            <begin position="721"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="1">
        <location>
            <begin position="793"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="1">
        <location>
            <begin position="832"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="1">
        <location>
            <begin position="872"/>
            <end position="906"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="1">
        <location>
            <begin position="1024"/>
            <end position="1060"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="1">
        <location>
            <begin position="1066"/>
            <end position="1100"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="1">
        <location>
            <begin position="1141"/>
            <end position="1183"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5075642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="1199" mass="132782" checksum="610BBF2B1F84D43C" modified="2022-05-25" version="1">MIYLKLKRTLDSYTEKKVFFHPEYKIHCIINISYASVSSEVKSAIFLFWYFAKKETDVGKKLWYSPHRYTSFFTGGKNFLDTLKVRCTNNYQCSSRMKHSECQNSICVCKPNYRATYDNKCIPLFGVECSLDDPCGTPNSACINKKCQCLRYYVFQNERCVQSRLNGYCKNNEDCSGIANAKCLKNRCICKDNYQRLNGFACGANLEGNCRTDEECMVPNSVCIDKKCQCRPNHLALGITKCIEAETLFGCSSNPECSDIWHAKCSDRNKCVCRENNIADGTSCLPLLSGYCWRDDQCRAHNSVCVDFRSYHSNDDDACQATGKSCNPEDAVPCCDDAVSCQASETPGLYICMEQEQLGSQCIYTSDCLKFHNADCINNKCGCSLNYIQLNSTYCAPKLGVFCAKEACAVRNSVCIDCKCQCSPNFSQSLDHCLATNLNQSCSVNTDCDGILFAECSTAKTCSCQSNYIQRGSNQCLSALDEACFGHSSCAAANSLCIDYKCQCKPRYASLSNSECVPIRINGVCRDNFDCQDSLNTICTDNKCQCDQDSFEADGKCVALLGGFCLTNSDCIVGNSSCIDHVCQCSHNYKPIGRNSCKPKLLGSACELDEDCDFIKNAKCVDNVCQCRDKYFGNSDFLCSPIIGGRCSNKSECFLNNLECIDGQCQCSEGSSAISSSQCLTTSLMFSCQHVSECADILHFECLNNKCVCKADNNISLSRAMCLPLLGGICWKNDQCIAENSACIDFRCQCNSGYVAAAKNFIRVNNSMCDGKCRCLPNYHFKNGGCLPKIGNHCVDEQCAADNSDCINQKCQCKQGYSFYYNNCMLVFMNISCDMDADCDGNGNAVCSRRECYCKVGYILKNNICVSVDEKFCSSTDRCLRRNFECIDNECKCTSDSLLLKSGLCLSTKLGQYCAEENECQLIKNAKCSRTQKCVCKSSYFPLSATTCGSLLGGFCWDKSDCPAPNFECIDDKCQCSAGFVPLTSSNCIDENLTLLCNHRTLLAPAARNTTLLAKYLGTSLGHPCKVDFDCKNIKNGHCSADKFCACVANHFGLSKYQCIPSLGGDCNDNNDCTVYASECIDNKCQCNANYSAVSGSQCKLTLSLVECNKTLDCGEHWHSTCSLNGRCICHKNSFMVNLWTCQPTLGGACWYDHQCITKNSFCIDFRCRCGEFFTRLSDNQCISTLLPSALEYKSLRFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2E587</accession>
    <name>A0A8J2E587_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">XK-related protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HICCMSTLAB_LOCUS626</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the XK family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001114">
        <property type="protein sequence ID" value="CAG5073831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2E587"/>
    <dbReference type="OrthoDB" id="6136301at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902742">
        <property type="term" value="P:apoptotic process involved in development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043652">
        <property type="term" value="P:engulfment of apoptotic cell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070782">
        <property type="term" value="P:phosphatidylserine exposure on apoptotic cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018629">
        <property type="entry name" value="XK-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050895">
        <property type="entry name" value="XK-related_scramblase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16024">
        <property type="entry name" value="XK-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16024:SF6">
        <property type="entry name" value="XK-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09815">
        <property type="entry name" value="XK-related"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="184"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="222"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="266"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="358"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="392"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="449"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="479"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="144"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU910716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAG5073831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="570" mass="65058" checksum="018B653A83FFE9AC" modified="2022-05-25" version="1">MRHTGNTKVACNDANNGRTLLIIRGLQTVYEFVPIILKDVISSDIKKNTPPKRLLVSNAVPTLLPPDNILKMPKNMPKPPLTNSTAKNLLVNVNNDEVIFERPALKDECSHNDRGITFEVRKATDTEPALINIETNSFVKISLRGKKSRKSQEPDPNDNSELDGVFPIPNFNTDVADLPESKALVTRLDIFWIIFSIITHLVDLGTDLNLSFRYYIKGQLMYFFITTAFLFIPSFINIIVSIRMYEQDSEMKAEGIKKQTLARRILKLKLCCPFILVFQLAPVLRYLDCLKYACQSYQCRKDNDNYGQRKYYIKMLKEEQDISLLRVFECFLEAAPHLVLQLTLIIYTYDGIVAVDSIFFHQLISILSALGSMGWAMSSYHRIIRLAQVSRIISISAAAAIFAVYTTIFCFIHWFIMTLWILSRPTGVIQFCRDQSKGSDAPLTIYERIGYYLFSAILGVVYVFTYLKPAEGSTFYRHIFYYTICGIENAAACIVWAIADYNTVLFLRSINLEYQSTGFCTTIRINSLSGATMTSCFLLRIRKNVRSFVGSRSRTTERALSDNWLINPAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2EA67</accession>
    <name>A0A8J2EA67_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Similar to SLC35F3: Putative thiamine transporter SLC35F3 (Homo sapiens)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HICCMSTLAB_LOCUS282</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLC35F solute transporter family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001114">
        <property type="protein sequence ID" value="CAG5073326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2EA67"/>
    <dbReference type="OrthoDB" id="10062838at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009262">
        <property type="entry name" value="SLC35_F1/F2/F6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026505">
        <property type="entry name" value="Solute_c_fam_35_mem_F3/F4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19346">
        <property type="entry name" value="SUGAR PHOSPHATE TRANSPORTER DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19346:SF4">
        <property type="entry name" value="SUGAR PHOSPHATE TRANSPORTER DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06027">
        <property type="entry name" value="SLC35F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="121"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="230"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="254"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="286"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="316"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="345"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="380"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="495"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="521"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="67"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="566"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="633"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="87"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="577"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="637"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="679"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="695"/>
            <end position="709"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAG5073326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="718" mass="78107" checksum="1F690AAB6812621A" modified="2022-05-25" version="1">MDSSNAEVSTIFHPRRSRAPSIILNDEQTGHPYASPGHVVVDTGCEQQGCSVTGGCDSASSCRSLETSSGLGIRDPSGGSAGGGQGHNQPSHTGSNVNYQTRRHSIVRCFDSCCAQSAKKIYFGVCVTVCVTASWVGATHCIKYLYFHKPDIITNHIESDNVTSELYHQPIVLPYNAPFFTTWFCTNWAVLYFPVYFICQIARSKCTNPTEIIAESLRGFRDKGLTGGRFLTRCSFFCGLWVATNYMYIHSLRILLATDVMALFATNVSCVYLLSWVILHEQFVGVRIVAVILCDTGIALLAYMDGITGSPTLGGVVLAASAAAGSAVYKVLFKKVIGETTFGQVSIFFTLIGLCNAALLWPICLALYFSGVESVHWARLPWAALLSASILHLGVLSLIFRVNMLNTEPGSLSIKVGCKITPKRQEFSSFFPPDVWFRFRVELAHQGDGVAVTTSQVSKRPLNHRQGLDITTDRQIYVCSSSLIISHQCQHNIALTYDLFITLGLITAVPVSAALDVVLYGAHFVGMKLAGMILISVGFFLVMFPDNWPDYITRLLRNVVTMSHSASTNPQQHGVASGRGVGGGGGGMTSNRSRRQSFQQRHFRRNYGVSSSQGDGQTLLPSTNNSAVSNLIHRHTNNNNNNNNNNNNNTNNNNNNNNTSNNNNVVSSSSDTQHHRVPNSNSIQSTTTNNHRSHVSPQNQQDGAENTGTGFPAALPGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2EAD9</accession>
    <name>A0A8J2EAD9_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS485</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001114">
        <property type="protein sequence ID" value="CAG5073542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2EAD9"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5073542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="136" mass="16069" checksum="935E373CC090A021" modified="2022-05-25" version="1">MILFSTNNYVDPHSANLWFFLYRFKRSRFHKKILDLAVHLQASCSFPYRLVRMYVFSIEYLALLLNNGDHLSFSNCNQSRGVSFFRFLLHLRNLFQDHYANRRIQPLIIRCTSILRGAARFRTFPGVSETPSSTKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2EAG3</accession>
    <name>A0A8J2EAG3_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to spopla: Speckle-type POZ protein-like A (Danio rerio)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS1362</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001116">
        <property type="protein sequence ID" value="CAG5075208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2EAG3"/>
    <dbReference type="OrthoDB" id="10249567at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030163">
        <property type="term" value="P:protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd14733">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.710.10:FF:000159">
        <property type="entry name" value="Speckle-type POZ protein B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.210.10">
        <property type="entry name" value="Apoptosis, Tumor Necrosis Factor Receptor Associated Protein 2, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002083">
        <property type="entry name" value="MATH/TRAF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008974">
        <property type="entry name" value="TRAF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24413">
        <property type="entry name" value="SPECKLE-TYPE POZ PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22486">
        <property type="entry name" value="MATH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49599">
        <property type="entry name" value="TRAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50144">
        <property type="entry name" value="MATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MATH" evidence="2">
        <location>
            <begin position="12"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="193"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5075208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="400" mass="45521" checksum="BAA3BAD1261443ED" modified="2022-05-25" version="1">MEGGCSHSEKHSVVYTWEINEVTSFFNAAKSTKVSKEIRSPTFSSSMKVKDSWNLHLKIGENSEKKFVIALFLELRNAEKEVRTRFSIFILNGKKEKIYVNNIRATTTNEQTFFNDRFFVSPATSLGYENFAVVDEIFSKKDEFLPNDTLTVCVDLTVYDDYVKVKNQVKSLENSKRKLGDDLKDLFIAKKRCDVIIHVGDQKFDVHKFILTARSCVFEAMFSYDMKENKKNEINIPDIDPEVFSKVIDYIYTDKVDELETFAEELLEASDKYQLQGLKEMCEDFLITTLTLGNAVRILILADRYNAKRLKKVAINYVADNFVKFKNTKELKALEEAQESIAGPSPVQLCTTLGQACKPELAQSWVKSGMITLAQAWLPRLAYVGLPGLGHAWLSGLGHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2EAH2</accession>
    <name>A0A8J2EAH2_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS447</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001114">
        <property type="protein sequence ID" value="CAG5073504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2EAH2"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5073504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="105" mass="11927" checksum="E90FB081F69E8C75" modified="2022-05-25" version="1">MAQLVSTYQKKGLGQRCQIHTLTLCGLPRVSRFLFYQKPRDLVSDHEGLSSRLPKLAIPMLAIDTLGNYPCEQGLRPFTDNQYAIRDTECGSVANTRRREGRTQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2EAM3</accession>
    <name>A0A8J2EAM3_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Mitochondrial import inner membrane translocase subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HICCMSTLAB_LOCUS1438</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Heterohexamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Intermembrane side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="1">The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the small Tim family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001116">
        <property type="protein sequence ID" value="CAG5075284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2EAM3"/>
    <dbReference type="OrthoDB" id="344165at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.810">
        <property type="entry name" value="Mitochondrial import inner membrane translocase subunit tim13 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004217">
        <property type="entry name" value="Tim10-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035427">
        <property type="entry name" value="Tim10-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02953">
        <property type="entry name" value="zf-Tim10_DDP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144122">
        <property type="entry name" value="Tim10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0143">Chaperone</keyword>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="1" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="1" id="KW-0653">Protein transport</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0811">Translocation</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Tim10-like" evidence="3">
        <location>
            <begin position="26"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU367043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG5075284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="97" mass="11009" checksum="94CF5CAB67B891B9" modified="2022-05-25" version="1">MTDLFGNTNFDEPKTPKSGVDNELNEFIMMEKQKAQLTAQIHEFNDFCWEKCVDKPGTKLDGKTETCLNNCVDRFIDVSLLITNRFAQLLQKSAGGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2ECX3</accession>
    <name>A0A8J2ECX3_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Similar to rnst-2: Ribonuclease T2 protein rnst-2 (Caenorhabditis elegans)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HICCMSTLAB_LOCUS1816</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the RNase T2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001116">
        <property type="protein sequence ID" value="CAG5075698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2ECX3"/>
    <dbReference type="OrthoDB" id="7696536at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033897">
        <property type="term" value="F:ribonuclease T2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006401">
        <property type="term" value="P:RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.730.10">
        <property type="entry name" value="Ribonuclease T2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001568">
        <property type="entry name" value="RNase_T2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036430">
        <property type="entry name" value="RNase_T2-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11240:SF75">
        <property type="entry name" value="RIBONUCLEASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11240">
        <property type="entry name" value="RIBONUCLEASE T2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00445">
        <property type="entry name" value="Ribonuclease_T2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55895">
        <property type="entry name" value="Ribonuclease Rh-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035144233" evidence="6">
        <location>
            <begin position="29"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="44"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="51"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="89"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="146"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="171"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAG5075698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="391" mass="45292" checksum="EEC3A98CCE8FA54E" modified="2022-05-25" version="1">MHDKMANFLCNHVVFLVKLLQIAGLKLAARITGDSETEFLKSISHSGAVHESAKRIRPERPRDRRTSKADSNNSDEEYSHSRHLIPPKVDSRSRDSSRRSYHHSQRDSSRSRDSSRRSDHQSKRDSSKSKESGRIGDYDSGAGPYKSRDSSHKRDSSRSNPSSRRSHSRSRRDSSKSRGTSDRSKSRSRPESSSKKSYASLRKCVDKRSSAKDCFDFFILTCYFPKAAALSAQNMGNKEYYEDKLKDDWSIHGLWAFSYKYGAELEKECGNLINMWFDEKLLLDNEDFVKELREKWFNIYKKDGYSDETFWKHEFYEHGKCATRSKHVKDLKGYFNLALKLFNNADLKNTLADGGFEPGKIVTWAEMYNIIKKKHGGYPKIEQLRDPVRFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2EDU9</accession>
    <name>A0A8J2EDU9_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Mitochondrial (Bos taurus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">HICCMSTLAB_LOCUS2247</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the isocitrate and isopropylmalate dehydrogenases family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001117">
        <property type="protein sequence ID" value="CAG5076671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2EDU9"/>
    <dbReference type="OrthoDB" id="10261637at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006102">
        <property type="term" value="P:isocitrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.718.10">
        <property type="entry name" value="Isopropylmalate Dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024084">
        <property type="entry name" value="IsoPropMal-DH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056173">
        <property type="entry name" value="Sec20_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11835">
        <property type="entry name" value="DECARBOXYLATING DEHYDROGENASES-ISOCITRATE, ISOPROPYLMALATE, TARTRATE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11835:SF42">
        <property type="entry name" value="ISOCITRATE DEHYDROGENASE [NAD] SUBUNIT BETA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00180">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03908">
        <property type="entry name" value="Sec20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01329">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53659">
        <property type="entry name" value="Isocitrate/Isopropylmalate dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="4" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="438"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="domain" description="Isopropylmalate dehydrogenase-like" evidence="9">
        <location>
            <begin position="43"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAG5076671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="460" mass="51346" checksum="116CEAE3E1753C08" modified="2022-05-25" version="1">MALLMRNVCKVLSKTTQNGAVRSFSASKVHHQESLVEQEGKTKCTLIPGDGVGPELVLSVQQVFKAANVPVEFEPYFLSEVNPTLSAPLEQVSNSIARNRVCLKGILATPDHSHTGELQTLNMKLRNKLDLYSNVVHVKSLPGVNSRHKNVDCVIIREQSEGEYSALEHECVKGVVECLKIVTATKSQRIAKFAFDYAVKNNRKKVTCVHKANIMKLGDGLFLKSCQEIAKLYPKHTYSEAVGKNVANPTALILCSVKLLNHINLKRYAVQIREALNRVLNEGKVRTKDLGGQNSTTDFTQAVISALHHLLAVIRQEIVKNHLLVTAIIQTEINVKKKAELMQEVEKRKSQLVFALAAFKKANIVGACVIDKMAKDELMSTSEEQQRMLRKRRDKRGLADTANKVNGTKDELEQQQQAIILSGKLLGKYGRREVTDKALLTLAFIFFLACVAYVLQKRLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2EDY5</accession>
    <name>A0A8J2EDY5_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Similar to pb: Homeotic protein proboscipedia (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HICCMSTLAB_LOCUS1775</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001116">
        <property type="protein sequence ID" value="CAG5075621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2EDY5"/>
    <dbReference type="OrthoDB" id="6159439at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000047">
        <property type="entry name" value="HTH_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45664:SF12">
        <property type="entry name" value="PANCREAS_DUODENUM HOMEOBOX PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45664">
        <property type="entry name" value="PROTEIN ZERKNUELLT 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00031">
        <property type="entry name" value="HTHREPRESSR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 5 6" id="KW-0371">Homeobox</keyword>
    <keyword evidence="4 5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="7">
        <location>
            <begin position="2"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="5">
        <location>
            <begin position="4"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG5075621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="217" mass="25129" checksum="E44012CBC5EF26D3" modified="2022-05-25" version="1" fragment="single">SNSKRQERTVFTNDQLLRLEKEYISQGKYLCRLKRGQVARDLGLNDRQVTVWFQNRRAKDKRVKSLNDDENKEKVPMAALPSTKIGCRMIQEEIKKEKTYQNTGLVASVPVPAPVIIHGEHQMHTLNYSSNSSTGIPQHNHLSSWDSYNRINYDTIHNQNYENFNGPDWNYNYINEHCSVPNGYANEAKAKGAFHTHYLSNCTSNNGDYYYPPGWNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2EF01</accession>
    <name>A0A8J2EF01_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS190</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030000997">
        <property type="protein sequence ID" value="CAG5072774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2EF01"/>
    <dbReference type="OrthoDB" id="6780149at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5072774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="73" mass="8350" checksum="3F958C12BFAECB05" modified="2022-05-25" version="1" fragment="single">AYTVDVMHDMLEGVVQREIHFIIELIVKKKILTLDIINTRIQEFNFGSIEMKNRPSPIVLKQSGLIGQRAAQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2EFW5</accession>
    <name>A0A8J2EFW5_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Similar to Tpcn1: Two pore calcium channel protein 1 (Rattus norvegicus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HICCMSTLAB_LOCUS765</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001114">
        <property type="protein sequence ID" value="CAG5073993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2EFW5"/>
    <dbReference type="OrthoDB" id="10068803at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005216">
        <property type="term" value="F:monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022832">
        <property type="term" value="F:voltage-gated channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000062">
        <property type="entry name" value="Two pore calcium channel protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.350">
        <property type="entry name" value="Voltage-gated potassium channels. Chain C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028801">
        <property type="entry name" value="TPC1_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027359">
        <property type="entry name" value="Volt_channel_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46474">
        <property type="entry name" value="TWO PORE CALCIUM CHANNEL PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46474:SF1">
        <property type="entry name" value="TWO PORE CHANNEL PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="127"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="157"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="197"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="255"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="281"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="313"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="540"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="579"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="654"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="684"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="domain" description="Ion transport" evidence="7">
        <location>
            <begin position="158"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="domain" description="Ion transport" evidence="7">
        <location>
            <begin position="458"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG5073993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="836" mass="96948" checksum="311FADCD3CCEDD1A" modified="2022-05-25" version="1">MNSSDDSRFSSQYQRFDDDVQENFRTSPKYGSILSCTSSDYQPKASTLENDTIPDSYQATPRDIEIDDLAESTVFAKQTINDPDIHWEMNYHEAAIFLEEGQNNEKFDSHPRHPEDLPAYLLVHNNWYYGLDLFTSLLLLALAFVEEPAVSIFQLPVWLHGSIELLALLTIGVELALKLRWIGWGTILKHKRTMLKCVTLAIMFLEAVIVVIRQSSHFRVTRALRPIFLVDTKYCGGVRRFIRQILQTLPPILDMLGLLLFFIIVYMVLGYFMFSETNRNFATLQDSFVSLFVLLTTANFPDVMMPSFSKSKWYAIYFVSYLSMMLYVMMNLMLAVVNETFTSAERDKFKKLFLHKRRACQHAFKLLVSKQNPDQMKFKQFEGLMRYYAPKKSTLDIILMFRHLNSSNSGALSCEEFLMVYDVTTLEWEPQYSGIPWYHTAWPPLQMLCNGAHIAIRWPYFETFVYASIILNGVAMGCRLLESSPNQVVAAHKFAADWDTLAFASLFVTEAMTKVLGLGIRRYLSSGWNLFDLGASVMPLIAACGLSLFPNAMFFVIFRPLRLLRLFKIKKRYRDVFGTLVILSPLMCSTAIVMLILYYFFAIIGMEMFAGYDMRNCCINTTVEDFYKYSANGSTTLGYYYLNTFDNLMASEMTLFELTVVNNWFILMNAYAVIVGFYTRFYFMTFYLVTMIVLTIVVSSFLEAFRFRIQYKKSTSKRDEEKMLHEEVELKWDELQTIIQDFHILEKLRSSLMVNNTTNYIGSRPRTREVLQRRMYTLEIQEWVAEAKVDEKSSEPLLSSSFDEIRVEDSNMDVGQIIDSRHNSLQHRNGLTTSPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2EJS0</accession>
    <name>A0A8J2EJS0_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to SMOX: Spermine oxidase (Homo sapiens)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS1334</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001116">
        <property type="protein sequence ID" value="CAG5075180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2EJS0"/>
    <dbReference type="OrthoDB" id="5046242at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046592">
        <property type="term" value="F:polyamine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.660.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050281">
        <property type="entry name" value="Flavin_monoamine_oxidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10742:SF398">
        <property type="entry name" value="AMINE OXIDASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10742">
        <property type="entry name" value="FLAVIN MONOAMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00419">
        <property type="entry name" value="ADXRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035306987" evidence="1">
        <location>
            <begin position="22"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="domain" description="Amine oxidase" evidence="2">
        <location>
            <begin position="37"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="Amine oxidase" evidence="2">
        <location>
            <begin position="216"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5075180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="463" mass="53252" checksum="ED8AF2CD332A29F8" modified="2022-05-25" version="1">MPKLILFLFVITTTINNIVLAEPVHDTRVIIVGSGAAGIAAASKLLQNGFNDVKIIEAENRIGGRLWAVKIGQWVHGEEDNVSFELAWPLGLLEHFNYSHVFTTRFFNSSGEQLLPEVLSDVTYFYFNLTENSDVNDIAKAESYGDFIIEKMEEYFKRLPEVTDDMKKSILYLFNLVQGSSDGSDDWTKLSPKMPRDYPKKYPNPAEELPVLNNTILNSKVVKINYDSSDTPVEITTEEGKKYLADHIIVTPSLGVLKADYEKLFNPPLPDKKINAIQNLEMGHVAKIYLYYEDPWWHDEIFVKFILWSDEERKQMEADPAKRWLLGYYTAVEVEHKPKVLCLWMTGPYVTEMEQVSEEEFNNKTLHFVNQFFGKSYNLTQPSIIKRSMWNTNDNFRGTYSYRSITSDLKNAQNKDLAEPIMKNDKPVVLFAGEATDEHFSTVHGAIHSGWREADRLIKLYKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2EL07</accession>
    <name>A0A8J2EL07_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">phosphatidylinositol-3,5-bisphosphate 3-phosphatase</fullName>
            <ecNumber evidence="3">3.1.3.95</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Phosphatidylinositol-3,5-bisphosphate 3-phosphatase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">HICCMSTLAB_LOCUS2316</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.95" evidence="3"/>
    <dbReference type="EMBL" id="CAJNRD030001117">
        <property type="protein sequence ID" value="CAG5076901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2EL07"/>
    <dbReference type="OrthoDB" id="271628at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052629">
        <property type="term" value="F:phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004438">
        <property type="term" value="F:phosphatidylinositol-3-phosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15738">
        <property type="entry name" value="FYVE_MTMR_unchar"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13210">
        <property type="entry name" value="PH-GRAM_MTMR6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14532">
        <property type="entry name" value="PTP-MTMR6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000135">
        <property type="entry name" value="Myotubularin related protein 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030564">
        <property type="entry name" value="Myotubularin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010569">
        <property type="entry name" value="Myotubularin-like_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048994">
        <property type="entry name" value="PH-GRAM_MTMR6-9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000306">
        <property type="entry name" value="Znf_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10807">
        <property type="entry name" value="MYOTUBULARIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10807:SF8">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-3-PHOSPHATE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01363">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06602">
        <property type="entry name" value="Myotub-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21098">
        <property type="entry name" value="PH-GRAM_MTMR6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00064">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51339">
        <property type="entry name" value="PPASE_MYOTUBULARIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 13" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Myotubularin phosphatase" evidence="15">
        <location>
            <begin position="126"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="domain" description="FYVE-type" evidence="14">
        <location>
            <begin position="604"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="active site" description="Phosphocysteine intermediate" evidence="11">
        <location>
            <position position="334"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="274"/>
            <end position="275"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="334"/>
            <end position="340"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR630564-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR630564-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CAG5076901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="668" mass="77023" checksum="91AF3A6C3A9FBD33" modified="2022-05-25" version="1">MNPMELIKIGKVENVRMLDRYSNKHSVGTLYLTATHLIFTYPNEKKQIWVLNTHIASIEKQPLTTAGSPLHIKCKHFLTMTFIITKERDCHDIYLTLMRLSSPARIDDVYCFHSRISKNLTPKFDGWSLFDIQNEFQRQGLPNSEWTLTYLNTSYELCDTYPRYLYVPSTCTNNVLVGSAKFRSKGRLPVLTYLHSNKAAICRCSQPLSGFNARCPEDEQMLYHILCTNPNAKFMYVVDTRPRINAMANRAAGKGYENENFYDNIKFRFFGIENIHVMRASLSKLIDLQKTTSMSAFLNGLESSGWLKHIRSILETSWFIAKAIINGTNVVVHCSDGWDRTAQVCSVAALLLDPFYRTIQGFQALIEKDWLAFGHKFSDRCGHITSDPKELAPIFTQFIDVTYQLMHQFPYMFQFNEYFLLVLHDHVHSCQHGTFIGNNEKERQLLRLSERTKSLWEDIAAEINEYINPLYACNNYKDECNKVLEPKLSPQNIELWKGLYFRFENGIHPRETGQDYVLALHNHTTSLEDHVKLLIKRVNNLSQLPKSQQNNQPNYNYDDEFSKDLDSEKIIDKDENDIGGANNDALVNQIESELKSVALDWKTSSKVEECSCCSTFDAFNKKNHCWSCGDVFCIRCIEEEPKLLSGHLSQRPVPTCKSCSRRSPITPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2ELN5</accession>
    <name>A0A8J2ELN5_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Serpin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HICCMSTLAB_LOCUS31</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030000232">
        <property type="protein sequence ID" value="CAG5071033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2ELN5"/>
    <dbReference type="OrthoDB" id="671595at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004867">
        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.497.10">
        <property type="entry name" value="Antithrombin, subunit I, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023796">
        <property type="entry name" value="Serpin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036186">
        <property type="entry name" value="Serpin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042178">
        <property type="entry name" value="Serpin_sf_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00079">
        <property type="entry name" value="Serpin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56574">
        <property type="entry name" value="Serpins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0646">Protease inhibitor</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0722">Serine protease inhibitor</keyword>
    <feature type="domain" description="Serpin" evidence="3">
        <location>
            <begin position="20"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG5071033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="114" mass="12725" checksum="9522D0C96B38D748" modified="2022-05-25" version="1" fragment="single">NDNPPTANPNTNKLLISSKLNFTLEALKQSALLETKDNLFFSPHSLHEALTLAFFGARGTTEEGLRQALRIPDSLSKVDIQRSYALEKSLKEFAALTGNVSTNYEFKTANRLWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2ELR0</accession>
    <name>A0A8J2ELR0_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to T: Transposable element P transposase (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS91</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030000584">
        <property type="protein sequence ID" value="CAG5071828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2ELR0"/>
    <dbReference type="OrthoDB" id="6770792at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048365">
        <property type="entry name" value="TNP-like_RNaseH_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21787">
        <property type="entry name" value="TNP-like_RNaseH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transposable element P transposase-like RNase H" evidence="2">
        <location>
            <begin position="158"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="53"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF21787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5071828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="375" mass="42346" checksum="10855BE177C3D432" modified="2022-05-25" version="1" fragment="single">MDNYHYDLFNSWLGLEISAEDENIEDTQENLTGCLDHHPHAQSNDNAEKSSRELLLEQQINELLEENASLKAEIALVNEKLSRFDDNLKKFLNPDQLLLLKNNAATNSKHWSEETIKKGLRIRLLMGTKAYKNLRDIEGFPLPAFSTLYSRLSGLNFAPGTFDNIIEWLGVKIKQEQDQTAHYCVLALDEMSIHPAVEYDRALEKFIGLVTPELARNSTEADSMASHAIVFVAWGLTSHWKQLIGYALTGKSVTSEVLWNYVKQIVEKLYQQGIIVKCISTDEGLTNVGMWSLNGITSSRYLVSSFSQHPCNSNERLHWTSDVPHVLKRIWSQLLKSTFTLSAATVVANNLTSSKVNITHVRQLVEYQSLGGPVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H043</accession>
    <name>A0A8J2H043_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS1504</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001116">
        <property type="protein sequence ID" value="CAG5075350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H043"/>
    <dbReference type="OrthoDB" id="10325114at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5075350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="218" mass="24114" checksum="76A2D061A1A66336" modified="2022-05-25" version="1">MPDGGFHEGLEERGKGFRDPHVSTSNVHPSAPGSFIRSIGDFKHQEANVVDKFINKIKHRDDGKHTAPGDVIRAFGDFKYRVADAADDVVDSVKIKAEKGKSFLGDIFDGFFQKKHLTSEYHSFQPTPLSPPFSPSIESGVYPVPPEFPSVSVDGSVSAISNLENTLYPYPDIKKPVSPRFVFIYDEGQRDLTIDDIIDAGKYLEGVKKIAANNKVNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H503</accession>
    <name>A0A8J2H503_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Similar to arrd-17: Arrestin domain-containing protein 17 (Caenorhabditis elegans)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HICCMSTLAB_LOCUS540</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the arrestin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001114">
        <property type="protein sequence ID" value="CAG5073646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H503"/>
    <dbReference type="OrthoDB" id="2333384at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.640">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014752">
        <property type="entry name" value="Arrestin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011021">
        <property type="entry name" value="Arrestin-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011022">
        <property type="entry name" value="Arrestin_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050357">
        <property type="entry name" value="Arrestin_domain-protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188">
        <property type="entry name" value="ARRESTIN DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188:SF176">
        <property type="entry name" value="ARRESTIN DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02752">
        <property type="entry name" value="Arrestin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00339">
        <property type="entry name" value="Arrestin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01017">
        <property type="entry name" value="Arrestin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0716">Sensory transduction</keyword>
    <feature type="domain" description="Arrestin C-terminal-like" evidence="4">
        <location>
            <begin position="178"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="320"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="366"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAG5073646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="426" mass="47471" checksum="655EA7ABF29A5F5B" modified="2022-05-25" version="1">MGLNDFRIVFDNPWSTYYPGQTVTGRVIVVLDAVKKVRGITVKVKGEANVCWATDRQELNNEGKYDNETQTVTGHEEYFNMEYYLLGSPSGSEIELPIGEHSYPFQCPLPPNLPSSFEHDHGYVRYTVKASIDRPWKFDHQVKIAFTVVSNFDLNKEARALEPVNLEMSKTFCCLCCGSPPLKVNIMMPVKGYVPGQAMMIRVNVENHSGIVVDTIKLILRKIVTFKANNPRFETKTEKIMIAEVSKGPVEGNATSDYQQKLDIPPLPPSNLTNCGIIDLEYNLKIEACVAGWYHRNLKQNMLVFIGTIPLASYQNSVMPPTSPSKVPMPGNPGADPTYGGYPSGYPEFSPDNGNPAPPSAPPDYNSDSPAQLQTNHNTYPNLPPPAYEEYGWSIRSIRDAGESDQVMGLRGHYAPRYPKWDSPGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H5G1</accession>
    <name>A0A8J2H5G1_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS679</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001114">
        <property type="protein sequence ID" value="CAG5073907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H5G1"/>
    <dbReference type="OrthoDB" id="7700486at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5073907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="296" mass="33905" checksum="EFC63AF62FE6CF61" modified="2022-05-25" version="1">MSNMPKLYAVVEFCEIFIDGKKVVELVPISWLTSDETLCFWPPTNLEYKSKELIEIQADADDTWDTYPIAIITKAKDYKKGNRKLKKYLKKRNGDSSESESQASRDDQIVITKSSRVAKTLAKANPMPLMRDPSIEDILEESSAEDNNAANNKEFKKMRQSLELSMTDKFEKLLKTIQYSGEAPAVQKAWQDLSNTLPFDSLEKFLAFEESLITDKQKKNSLLLYSGCGKRFKGVGKRSFKDTESFKIIEEFLRAKHHASQRKLEIISWVSKFLSGAKDREGGRALRENKTNEMTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H5Y0</accession>
    <name>A0A8J2H5Y0_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Limulus clotting factor C-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">HICCMSTLAB_LOCUS2474</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endomembrane system</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001117">
        <property type="protein sequence ID" value="CAG5077486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H5Y0"/>
    <dbReference type="OrthoDB" id="6147874at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00033">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00112">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000068">
        <property type="entry name" value="transmembrane protease serine 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.400.10:FF:000065">
        <property type="entry name" value="Transmembrane protease serine 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.70.10">
        <property type="entry name" value="Complement Module, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.400.10">
        <property type="entry name" value="Low-density Lipoprotein Receptor"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001879">
        <property type="entry name" value="GPCR_2_extracellular_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036055">
        <property type="entry name" value="LDL_receptor-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050685">
        <property type="entry name" value="LDLR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023415">
        <property type="entry name" value="LDLR_class-A_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002172">
        <property type="entry name" value="LDrepeatLR_classA_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035976">
        <property type="entry name" value="Sushi/SCR/CCP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000436">
        <property type="entry name" value="Sushi_SCR_CCP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24270">
        <property type="entry name" value="LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24270:SF62">
        <property type="entry name" value="LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00057">
        <property type="entry name" value="Ldl_recept_a"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00261">
        <property type="entry name" value="LDLRECEPTOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00032">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00192">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57535">
        <property type="entry name" value="Complement control module/SCR domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57424">
        <property type="entry name" value="LDL receptor-like module"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50227">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01209">
        <property type="entry name" value="LDLRA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50068">
        <property type="entry name" value="LDLRA_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50923">
        <property type="entry name" value="SUSHI"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <keyword evidence="10" id="KW-0768">Sushi</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035275131" evidence="11">
        <location>
            <begin position="18"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="14">
        <location>
            <begin position="270"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 1" evidence="12">
        <location>
            <begin position="332"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="14">
        <location>
            <begin position="352"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="13">
        <location>
            <begin position="424"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="61"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="68"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="80"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="143"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="150"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CAG5077486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="665" mass="74248" checksum="F106B51880250558" modified="2022-05-25" version="1">MFRIIIFFLLVSKNVYSQAVEPPVFACVDGFKINVTQICDGIVDCPDSSDELKKLCYHIVCPVSSYRCNYGACISKSFRCDGFQDCIDGSDETHCETPNDCTSHEYQCVQSLECIPFFQTCNGYVDCKDESDESAESCKDYFCPAHTYQCEYGGCIHPEIICDGTEDCPDGSDEKISTCAAINCVGDTCLNYNCQPNEFSCKSGGQCISIYKVCDGAQQCRDASDETPENYGFFQCDYGACIPDSLKCNLEPNCHDWSDETICDSSLPNGACRLPSAKPGTHYTVSQYPQSRPGQIVPELTRLDFSCDVEETLEGSSHAYCQNNNWVPYVPTCYSERQEITCPSLDGPATNKRCEVLWGPKQGWISCHESMPIGTHVTLECPEFYERKSGSFFTTCLHDGTWSQVPLQCKPICGTRNEIATPLIVKGWEISPDESLPWHATLFSHENGHWKFFCGSSLIHESAIITAGHCVWKTDPETIRVIFAGFSSNFTLDEQNMETQIIGVSEIKIQQMYRDHEGNYGSDIAILILDKPVTITNNVKPVCLDWRVTSDVSLRSEEMGLVTGMGITENDTFSDKLRITTVKIIPENECQESQKRDFRKYLTYTTFCAGWSNGTAVCNGDSGGGLVLQRPDEKIWDLHGVVSISPRRLGTNICDPNYYTVFTKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H5Y5</accession>
    <name>A0A8J2H5Y5_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">HSP70.3_Cc</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HICCMSTLAB_LOCUS2491</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001117">
        <property type="protein sequence ID" value="CAG5077536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H5Y5"/>
    <dbReference type="OrthoDB" id="2401965at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd10233">
        <property type="entry name" value="ASKHA_NBD_HSP70_HSPA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.34.10:FF:000002">
        <property type="entry name" value="Heat shock 70 kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000002">
        <property type="entry name" value="Heat shock 70 kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000172">
        <property type="entry name" value="Heat shock 70 kDa protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.30.30:FF:000001">
        <property type="entry name" value="heat shock 70 kDa protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.10:FF:000024">
        <property type="entry name" value="Heat shock protein 70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000026">
        <property type="entry name" value="Heat shock protein 70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="entry name" value="Substrate Binding Domain Of DNAk, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029048">
        <property type="entry name" value="HSP70_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001413">
        <property type="entry name" value="PRK00290.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19375">
        <property type="entry name" value="HEAT SHOCK PROTEIN 70KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100934">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100920">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00297">
        <property type="entry name" value="HSP70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00329">
        <property type="entry name" value="HSP70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01036">
        <property type="entry name" value="HSP70_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0346">Stress response</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="606"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="618"/>
            <end position="637"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAG5077536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="644" mass="70900" checksum="E26DA6BB6896FCC1" modified="2022-05-25" version="1">MPAIGIDLGTTYSCVGVWQQGKVEIIANDQGNRTTPSYVAFTDTERLIGDPAKNQVAMNPSNTVFDAKRLIGRKFDDPKVQSDMKHWPFKVISEGGKPKIQVEFKGEVKRFNPEEISSMVLTKMKETAEAYLGQKVRDAVITVPAYFNDSQRQATKDAGAIAGLNVLRIINEPTAAALAYGLDKNLKGEKNVLIFDLGGGTFDVSILSIDEGSLFEVKSTAGDTHLGGEDFDSRLVDHLCKEFERKYRKNLKSNPRALRRLRTAAERAKRTLSSSTEANIEIDALFEGIDYYTKISRARFEELCADLFRSTLEPVEKALADAKLDKKSIHDVVLVGGSTRIPKIQSMLQNFFCGKALNLSINPDEAVAYGAAVQAAILTGEGDKNSALQDVLLVDVAPLSLGIETAGGMMTNIIERNARIPCKQSQTFTTYADNQPGVSIQVYEGERAMTKDNNLLGKFELSGIAPAPRGVPKIDVTFDMDANGILHVTAKDTASGRSNDVRITNDKGRLSKEEIDRMLSDAERYREQDQQQRDKVVARNQLETYVFSVKQAVQDNGSRLSQSDKDQVTRLCDETIQWLDNNTLADQEEYKHKLDELQKQCSPIMTKLHQGGGGANPADSQSCGAQYAQGNNNSYSGPTVEEVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H6S8</accession>
    <name>A0A8J2H6S8_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS2952</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001117">
        <property type="protein sequence ID" value="CAG5079199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H6S8"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035250527" evidence="1">
        <location>
            <begin position="21"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5079199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="188" mass="21333" checksum="13F3C84D673A0EE9" modified="2022-05-25" version="1">MCVMRATLCCCLLSICNVSCNDIKIIKQTGISSHLCRDVKELAEMCFKSNSNPVFISADLISKDWDPGGNSWVVIDHKFQKQAMGFNSAYPTYVLSFESMGYLKAAINHFRKSTAWSIKSPFLIVEKKSLCSNAGEVLQFMWKEDLLAVYYLCSHQYIYNDCFQVKSICNPRSSTVGFFLDLAIMESY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H6Z6</accession>
    <name>A0A8J2H6Z6_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">sphingomyelin phosphodiesterase</fullName>
            <ecNumber evidence="5">3.1.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">HICCMSTLAB_LOCUS3025</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; sphingolipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Sphingolipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the neutral sphingomyelinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.12" evidence="5"/>
    <dbReference type="EMBL" id="CAJNRD030001117">
        <property type="protein sequence ID" value="CAG5079490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H6Z6"/>
    <dbReference type="OrthoDB" id="387657at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004767">
        <property type="term" value="F:sphingomyelin phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006665">
        <property type="term" value="P:sphingolipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038772">
        <property type="entry name" value="Sph/SMPD2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16320:SF24">
        <property type="entry name" value="PHOSPHODIESTERASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16320">
        <property type="entry name" value="SPHINGOMYELINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="13 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0746">Sphingolipid metabolism</keyword>
    <keyword evidence="6 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="310"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="15">
        <location>
            <begin position="10"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CAG5079490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="348" mass="39553" checksum="34F206BB7549EF0C" modified="2022-05-25" version="1">MDQEIRFKVLTLNCWGIPYISKNKNERIKAIAEQLSSNDYDVVCLQEVWSAKDYDMIKNKVKKKLIYSHYFYSGVLGSGICVFSKYPIQDVMFYQWSLNGYVHKIHHGDWFGGKGVGLCRLRVIDANVNVYVAHLHAEYDCENDEYSAHRILQAFDTAQFIRMTEQGADVTILGGDLNTGPDDLAYRIISGVASLTDSCSTHGNKGTSECANNSYTCRKVANKSPQGKRIDHILYLGSKNFKADVVNCHQPFPDRIPNKNFSFSDHEAVETEFKFTRGVYEVNNIDIRSTLKEASHVCSEALQNVRKQRFWYSMMSIVLVIPIIYSISLDITFQSIGAIIGLNITKFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H8R7</accession>
    <name>A0A8J2H8R7_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Gustatory receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HICCMSTLAB_LOCUS4346</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Cell membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the insect chemoreceptor superfamily. Gustatory receptor (GR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5085332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H8R7"/>
    <dbReference type="OrthoDB" id="7686275at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050909">
        <property type="term" value="P:sensory perception of taste"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013604">
        <property type="entry name" value="7TM_chemorcpt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08395">
        <property type="entry name" value="7tm_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 7" id="KW-0675">Receptor</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="54"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="94"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="270"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="308"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAG5085332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="409" mass="47086" checksum="BD590B0CA5DBF984" modified="2022-05-25" version="1">MVVIDNLSKSDIQLLSLISSTYKLFSLAPVSVLEYPTYRNHKKEIAIEFTSTSSALFINSLGLLILLPLEVFYLYGKFIEDLEEESHLRHHFDIFFRINVIVIQVFLILIFSIKRREITAILNSVLSFESELVRNLRDLDQLHTGQHHQLAIFTAYFLISSVLLFNKLMVQDTLQAVANVLPKFAIRNLMIQYSILLIFIKKKYFSLNESLLVLTNRSGQMCYPFISIFDPPSEETVLDFVIFIRKSYSNLSEISNSIAQFYSIPMLVSLVYYFLGAVYVGYLFVSSIGDYLGDKTGGKIPDCIDHGLLFIMCIYPTIVLANSVTAVLEEVMYVKHTGISYEVSLFFQIFHSTKFYNPNQFQLEQFSMELFHQNVSFTAFEMVPLDNSRLTSVSVQYDAHLYNYPAPNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H911</accession>
    <name>A0A8J2H911_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to ctu2: Cytoplasmic tRNA 2-thiolation protein 2 (Danio rerio)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS3833</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5083414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H911"/>
    <dbReference type="OrthoDB" id="25129at2759"/>
    <dbReference type="UniPathway" id="UPA00988"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016783">
        <property type="term" value="F:sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002143">
        <property type="term" value="P:tRNA wobble position uridine thiolation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03054">
        <property type="entry name" value="CTU2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019407">
        <property type="entry name" value="CTU2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20882">
        <property type="entry name" value="CYTOPLASMIC TRNA 2-THIOLATION PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20882:SF14">
        <property type="entry name" value="CYTOPLASMIC TRNA 2-THIOLATION PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10288">
        <property type="entry name" value="CTU2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0819">tRNA processing</keyword>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5083414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="485" mass="54398" checksum="EF4ECC2E45C97F57" modified="2022-05-25" version="1" fragment="single">AIVPPNLQLFLSVSGSLLCTLCITLYYCSWCCCLLCKSCRCLGETNTAHARHLGEITLKNENCRKCNSKSHIKLRGSDNYCNDCFEAYATHKFRGTLGKSKLVRPNDKILVGFSGSAGSVALLNLIRAGMQESVHKRLVFETQVIFIDYFLEPRTEIEKKTTIDSIITLIKSFGFPGYVSSLSEIYNPEVKIHKIDEINYNYCQQASEESLKNLFQALTNETAKQELLKKLRLTLLASIARNLQCSKVFLADSATSLAVDILSNVAVGRGAQLSLDVGFVDDRFQELAILRPMRDFTKQELDYYLELHGLEPLKRNKKTNDNPFESIQKLTEDFVLDLESQFTGTVSTVYRTGAKISSQGFSAEEEQVCVICNAPVDTKPQDGATAILATEFSRFISTRGVRAVERNNGDCGSFKEPCGGCEGDCGSKKEQRVTVEQLRRFLCYGCRLIVHDKFEVDKLPGNITKKVKQLACFEDMREQIKDFLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H945</accession>
    <name>A0A8J2H945_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box only protein 9</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HICCMSTLAB_LOCUS4511</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5087429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H945"/>
    <dbReference type="OrthoDB" id="2117972at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031146">
        <property type="term" value="P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22089">
        <property type="entry name" value="F-box_FBXO9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1280.50:FF:000012">
        <property type="entry name" value="F-box only protein 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045464">
        <property type="entry name" value="Hrt3/FBXO9_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12874">
        <property type="entry name" value="F-BOX ONLY PROTEIN 48-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12874:SF29">
        <property type="entry name" value="F-BOX ONLY PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19270">
        <property type="entry name" value="FBO_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="repeat" description="TPR" evidence="7">
        <location>
            <begin position="87"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="F-box" evidence="9">
        <location>
            <begin position="192"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="F-box protein Hrt3/FBXO9 C-terminal" evidence="10">
        <location>
            <begin position="256"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="24"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="57"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="25"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="57"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="67"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF12937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF19270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAG5087429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="448" mass="52890" checksum="1C65B2B2BE659707" modified="2022-05-25" version="1">MTTTMAAVHLAKLFFRCVNQQGGSEADEGADEGESSSSPRIQDALANFREQWQRELKISPKKEVPSHSKSGKTSSIETHELSTEDKAKDLFLKGIEYERNGELYDAIRFYKRAVSLVPDIEFRLYESMKPKNKEKIKKNEDIQIVEYPGESYGNDEVDVREDGALVVKLSRIINKNQCLCFPCFEQSMTHVSALPLEIILYILRWVVSSELDIRSLEMFSRVCRGFFISARDPEIWRLACVRVWGVNCGQYEPRYRSWRDMYLKRPRLQYNGCYISKTTYIRQGENSFQDEFYRPWHLVEYFRYVRFFPEGRVLMLTSTDDAQNCVNALKYRTPRNLAVLIGHYRLHDNCITLVMKKQESKSNINHNYKKKKREIIHDSGEQTFHLELEIQSLHKRKNWQLLWIRYNIFTQYKNGQQATTCLNVFNRYPSLKFSRVKSYTQESDRPLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H9J5</accession>
    <name>A0A8J2H9J5_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS4871</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5088493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2H9J5"/>
    <dbReference type="OrthoDB" id="8964374at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="56"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="122"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="361"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="473"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="544"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="26"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="155"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="366"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="393"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="404"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="564"/>
            <end position="574"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5088493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="592" mass="67349" checksum="8377B00C8943D50E" modified="2022-05-25" version="1">MEKEQLDSLQTVTVGSEKIPPPHSHYAPSEVYSSSESPPAYSRPVMKSTAVQIAKIIATTLITISVIIGSFILAAAWLQARASCTPEAINGMQTQINSQQEFIKHLQPEALVQDPIDVKQNIDESSVKTKQPTAEPKEEETQTDNQDDSKADNESANDNENDDDYNDSGFSPVHFKFSPQLDLDDLANTLMQQSRGLVSCVVERRRSDGFTDGNNQVDNNNNNDYQRPQRLSGERVVILCESGEPRRQEQQEQDLRTPIIVPLGNIQIPMQPHEQDYHRYQVQNQFSAPDVQTPPFVNARRINQLEQGISIPDIKNIAQMMGFGSPRMPPQMNHQQMELRPFPIEIRTLPIEVIRGMRPPMNQMEQHQPQPQQQQQPPQPQHPMFAQEPTEPVYSQEQQTQGMMPPPPPPSAPNAPELNQREPRIIPQVHIIQQQLEQKPAQPQEAQDKPNFPFPGLPIDIIRFIQQPENMEAHRQENVEGSQESTKLIADSENQEESKDDEDKKKIVVLPESSLIHQIEERLFPRSHFSMPMRSMDTFQIPMEVSARVMGNSGEQEDNKEQHQPMQAQVMPQSDEQEDASRPHYVQPRSIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2H9N5</accession>
    <name>A0A8J2H9N5_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Similar to TANC2: Protein TANC2 (Homo sapiens)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">HICCMSTLAB_LOCUS4532</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Postsynapse</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the TANC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5087513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5958958at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098794">
        <property type="term" value="C:postsynapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058018">
        <property type="entry name" value="AAA_lid_TANC1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050889">
        <property type="entry name" value="Dendritic_Spine_Reg/Scaffold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058056">
        <property type="entry name" value="WH_TANC1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24166">
        <property type="entry name" value="ROLLING PEBBLES, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24166:SF55">
        <property type="entry name" value="ROLLING PEBBLES, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25520">
        <property type="entry name" value="AAA_lid_TANC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25521">
        <property type="entry name" value="WHD_TANC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="3 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0770">Synapse</keyword>
    <keyword evidence="4 12" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="14">
        <location>
            <begin position="7"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="10">
        <location>
            <begin position="1119"/>
            <end position="1151"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="10">
        <location>
            <begin position="1230"/>
            <end position="1262"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="10">
        <location>
            <begin position="1309"/>
            <end position="1341"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="10">
        <location>
            <begin position="1342"/>
            <end position="1374"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="10">
        <location>
            <begin position="1375"/>
            <end position="1407"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="12">
        <location>
            <begin position="1548"/>
            <end position="1581"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="109"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="384"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="473"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="392"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="473"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="507"/>
            <end position="517"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00034110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CAG5087513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="1629" mass="178577" checksum="631DC4F9650A9E20" modified="2022-05-25" version="1">MLAGSTCPSCEMPFDKGKKRRLIDSCGHERCYSCLFRSEACPICRHDAPDRQIREDVTHYDTGFSSSEPVSMIAIDDWNDNEDPSAVNSLCSSPLPKPKFSRSNIVYRSHGQDVGKGPKGKPPVLPESVTSRHKSHMAATVMSIYHEPLPLALYLSVESIYHESRTVESVNLSSNTWYLVPGTWYLVPGCPTPPNQRRRFFLNPKGLRSPFASQRAKKCSPVDVENPSALSAWMTNSWEGTSKWPGVVLGKIKSLWSTSQGTANDGLNQLIDPPIKDDRLTRLVTPTRNVTDITGSQQFASNRGTTGRRFYSRRPFVVIPDDEGGNVKPLSTKTRKSSQSDLYMRLGLLLGSNNLRTNSSVDTTDFPGTNRLPSASACVRPATRLEPRGHDTSFSSLTSFDQQTMASTNTSPVSTLTGTSSEAEVAAALRTSSCKTKGKSKIKGKRDCDSAGSLASISTSISASTSMSMSMSVSVSGLSNGSSSSPLTSRRHSNVAHQEPDDNTALNKRRSCARRTARNGNVKPIDSKLRFVTPHLTAQLTLKPLFFEVPLIERDPLFTGRNWLLKELETVVKGSSPGVLVTGSPGTGKTALILQLVEYSCFGRRREQSLSLEIAECDEDLPDKQMPIAGFEQSIKNTNDKIRQLAAHVVAYHFCQADNNSTCLVPDLIHSLAAQLCQAPQLIAYREYLLSEPHLQGSLSQRECTVDPDLALSRGIIEPMLSLRKSGRLPEVNMVILIDAICEAEYHRPDRGDTIASFLTRHAPNFPSWLKIVCTVRTQLRECAKQFPYTRLTLDKNANDPAGSNVSRDLADYINYRCIQSPAIQANVTASINGKESSCGANQTRFASHLLSLAGGSFLFAKLTLDLIESGHLVAKSASYKVLPVSLAQIFQLHFNLRFPTGTSFEKIQPLLGVCLAALYPLTLPEIFYSVNSLYTDQFVSWEDFLQRFKMLSGFLVKRLDDTYMFFHPSFREWLIRRDDGESTKFLCDLRLGHSAIAFRLSRLEAPLDGDRVLELGHHVLKAHVYRGVTSSWPSRDLQAWWITSSTTCVSSALCTLRNIYSPNVKVSRLLLLAGASPNHITEYLGNAPVLCMYAHEGSVEMVSLLLEFGADVELTNSQGCTALSLAASRGHCDVVRRLAAAGASLGHADMAGQCPLVHAARQGRLSVVGYLLACDWVLHQDPEDTSSDTSREEAAQQAVVAAASQGHEAIVEYLLDMAEVTVDRPDTLIGETALTIAAAHGSTATVSALLARGASPLATNAKGLFPLMLAAREGHWGTAERLLQSSVSTSTEANLNEAAALLEQRDSMGRTPLMMAACEGHTNLIDMFLEKGSILEATDKEGLTALGWACVRGRVAAAQNLIDHGADISANDKTGRTPLDLAAFQGNPKLVQLLLERGAAIEHVDLHGMRPLDRAIGCRNIPVVQCFLRRGAKLGPATWAMAQGKPDVLLILLNKLLEDGNVLYRKGRLKEASHRYAYALRKFPGSPELLHDPQNQEHGNVVLHRQSFNQLKLNFLLNLSRCKRKMNECEEAIELADEALNTRPSSYEAFYARAKAKVDVGQLENALTDVQEALQIAPINNRQDRRVLCALKDEIVSRIEGTGIGCSKTVADITRSRFRASVDTLTEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HAC1</accession>
    <name>A0A8J2HAC1_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">BED-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HICCMSTLAB_LOCUS5587</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5090328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HAC1"/>
    <dbReference type="OrthoDB" id="7699906at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009791">
        <property type="term" value="P:post-embryonic development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003656">
        <property type="entry name" value="Znf_BED"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052035">
        <property type="entry name" value="ZnF_BED_domain_contain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481:SF10">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02892">
        <property type="entry name" value="zf-BED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00614">
        <property type="entry name" value="ZnF_BED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50808">
        <property type="entry name" value="ZF_BED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="BED-type" evidence="10">
        <location>
            <begin position="77"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="38"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="436"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="47"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="443"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAG5090328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="455" mass="51893" checksum="335466F291BB9436" modified="2022-05-25" version="1" fragment="single">MLKNYRYRCQNISRYLNETWSTPIKTLDDDIEVNHDLSKAKNDTSSKKSAPNVQMNSNEATVSTASKKDVGMKRKRPVKSDVWNFFIKNEKDGTCKLCLKLISAPGCTTNLTNHLKGVHGNVYKPSTPSVIDNAVRPVIMKVQSTEKKLTQLRIDTIKDEINSCKSGPKSEKISNALIYMIVKDDLPLSATDKPGLQKLLQIECLYYEIPGRNKITTLIEHKAEALKLLFQEKLSKIECFSLIADVWTDTHNSRSFLGCTAHYHFEGKLSEAVLVNILRPAEIVTKNLSGEKYVTISDDIFCYYFIINEVKKVECRSETIKTARSYLIERMRLRFKGLESHSLIFVAGILDPRYKNSIFPNDDAAYQARKKVIDLIQKRTPIHQESTPTNSLKPTEKKKSSFYGSQELKNYYQQHIAAKSKNRTTSTTNLDELEFKKFLDSPPQENENAIDSINI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HAW5</accession>
    <name>A0A8J2HAW5_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="17">CYP6AS67</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">HICCMSTLAB_LOCUS6030</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="2">May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 14">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Endoplasmic reticulum membrane</location>
            <topology evidence="4">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Microsome membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 15">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5092304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HAW5"/>
    <dbReference type="OrthoDB" id="2789670at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11056">
        <property type="entry name" value="CYP6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000042">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050476">
        <property type="entry name" value="Insect_CytP450_Detox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24292:SF54">
        <property type="entry name" value="CYP9F3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24292">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 14 15" id="KW-0349">Heme</keyword>
    <keyword evidence="11 14 15" id="KW-0408">Iron</keyword>
    <keyword evidence="13 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 14 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0492">Microsome</keyword>
    <keyword evidence="12 15" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="10 15" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="14">
        <location>
            <position position="442"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CAG5092304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="497" mass="57891" checksum="D91BE26E4A3405EB" modified="2022-05-25" version="1">MITLEHIGYFILFLIFIYWYTTATFKFWSSRGVAGPKPTAFIGNFHDVLFSKISLGEWLAKYYHEYPNEPMVGVFVRRTPLLILRDLDLIKDVFIRDFSKFHDRGLKTFEDADPLSQNLIKLEHARWRPLRNKLSPAFTSGKLKEMFYLLAECGNYFQDYLERTVAKDEPIEVRDLTARFTTDVIGTCVFGVQMNAMSDENSEFRRMGKYVFKVNSFKLFRFRVRELFPAIYKIIGPAMKDKMIVDFFMNTMKDAIAYRRKYNVVKHDFIDQVMELQDNPDKIEIKLTDELLTSQLFVFFLAGFETSSTTMSNALYELALHQDVQDKLRAEILDTLKACNGHLTYDVIKSMKYMEMVFRESLRLYPPATLLVRRANCKYTFSGTNITIPTDMKIMVPVLAIHRDPHIYPNPEIFQPERWTPEGKASRHPMTWLPFGAGPRSCIGARFSNHQSKVGLIKILEKYSVHPCEKTEIPYKIHPTGFLLAPLNGIHLKFSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HCN6</accession>
    <name>A0A8J2HCN6_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Molybdenum cofactor sulfurase</fullName>
            <shortName evidence="4">MCS</shortName>
            <shortName evidence="4">MOS</shortName>
            <shortName evidence="4">MoCo sulfurase</shortName>
            <ecNumber evidence="4">2.8.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Molybdenum cofactor sulfurtransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Protein maroon-like</fullName>
            <shortName evidence="4">Ma-l</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">mal</name>
        <name evidence="7" type="ORF">HICCMSTLAB_LOCUS4955</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="4">Sulfurates the molybdenum cofactor. Sulfation of molybdenum is essential for xanthine dehydrogenase (XDH) and aldehyde oxidase (ADO) enzymes in which molybdenum cofactor is liganded by 1 oxygen and 1 sulfur atom in active form.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O</text>
            <dbReference type="Rhea" id="RHEA:42636"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:71302"/>
            <dbReference type="ChEBI" id="CHEBI:82685"/>
            <dbReference type="EC" id="2.8.1.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. MOCOS subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.9" evidence="4"/>
    <dbReference type="EMBL" id="CAJNRD030001119">
        <property type="protein sequence ID" value="CAG5088720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HCN6"/>
    <dbReference type="OrthoDB" id="420046at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008265">
        <property type="term" value="F:molybdenum cofactor sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030151">
        <property type="term" value="F:molybdenum ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03050">
        <property type="entry name" value="MOCOS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005302">
        <property type="entry name" value="MoCF_Sase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028886">
        <property type="entry name" value="MoCo_sulfurase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005303">
        <property type="entry name" value="MOCOS_middle"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14237:SF80">
        <property type="entry name" value="MOLYBDENUM COFACTOR SULFURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14237">
        <property type="entry name" value="MOLYBDOPTERIN COFACTOR SULFURASE MOSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03473">
        <property type="entry name" value="MOSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03476">
        <property type="entry name" value="MOSC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141673">
        <property type="entry name" value="MOSC N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51340">
        <property type="entry name" value="MOSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 4" id="KW-0501">Molybdenum cofactor biosynthesis</keyword>
    <keyword evidence="2 4" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MOSC" evidence="6">
        <location>
            <begin position="633"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="491"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="393"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="4">
        <location>
            <position position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAG5088720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="724" mass="82275" checksum="42AE6BB79500260A" modified="2022-05-25" version="1">MDQFVNYSEVYDNITIQQFKNDFNNDECYLDHAGATLYSKTQIKFIYQDLSESLYTNPHSAVGSGNQCQEIIERTRSRILDWFKASEDYSLVFTSGATASLKCVAETFEFNDGKFIHLQDNHTSVLGMRDVIAQKNVSVESMTREEAFQHFSADRSAVRINSDKKSNSLFVYSAQCNFSGYKYPLEWIEKVHRGALDQDGNSNWFVLVDAAAFVGTNVLDLSVYKPDFVVLSFYKMFGYPTGLGALIVRNSSAGMLKKIYYGGGTVNIALSTQNFHVKKEVFHDRFEDGTLSFLSIIALQHGLDALSKLPMHQISSHVFSLARYVHHYLQSLHHANGNPVVELYSDSDYEDPLQQGGIIALNFLKPNGEYVGYMEVLHMASLFKIHLRTGCFCNPGACQRHLKLSIQDIISNYDAGYTCGGGKDLIDGRPTGAVRISFGYMSTFADVEVFIKMLHKCFIDLPAMIKISQINFINNINSSSKGRNKILNLENFKVEELKENLKIKIEKIDEKKNNEIKLKKIFIYPIKSCGAYQVPQKWIINNKGLKYDREWMIITGAGVCLTQKQEVKLCLLRPTLNLEENFMRLEYPGMLDIEVPLESIGDKKVDGEICRSRVCGHRVEGIDCGYEISEWLCQALGRSDLKLIRQNLDDGELSFSSQAQYLLINSASIQWLVDRLPGDSDCDKNTVLDRFRGNFVVDGAEAFEEINWKQVFIGKHSFEVRWYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HDW2</accession>
    <name>A0A8J2HDW2_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Similar to cc_single_3.5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS6143</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5092448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HDW2"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5092448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="114" mass="13164" checksum="8366BF3A2E747420" modified="2022-05-25" version="1">MAQLVSTHQKKETRTKVPDPHSYTLQATACLPHTKRAPACLFNLRHRKTFEASCSITRASFAIFPNLIELCSRSIIRDFTRASKGYDNKIRYCSNDLRRYIQIIIIIIIIIINI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HEB9</accession>
    <name>A0A8J2HEB9_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Similar to CCNT1: Cyclin-T1 (Equus caballus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HICCMSTLAB_LOCUS5893</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the cyclin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5092073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HEB9"/>
    <dbReference type="OrthoDB" id="25002at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043198">
        <property type="entry name" value="Cyclin/Ssn8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10026">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0195">Cyclin</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin-like" evidence="4">
        <location>
            <begin position="38"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="141"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="345"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="753"/>
            <end position="968"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1039"/>
            <end position="1061"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="174"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="205"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="222"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="255"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="283"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="299"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="351"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="365"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="396"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="760"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="786"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="797"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="833"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="859"/>
            <end position="868"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="898"/>
            <end position="907"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="925"/>
            <end position="939"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1039"/>
            <end position="1049"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAG5092073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="1061" mass="120419" checksum="228BB809DFC8541F" modified="2022-05-25" version="1">MATEEKWYFTKEQLANTPSRKCGIDADKELSYRQQAANFIQDMGQRLVVTQLCINTAIVYMHRFYVFHSLSQFHRNSIASAALFLAAKVEEQPRNEQGLSPDFILHGIEQIMSISERQSPSMHHPSLPNSPFDVEPRRVAAVDDGGPSFQSARPYPAEEDKKKPPSQPSTRPPTDYREYRDKKERERLEREKMSQNSGSLPQDSKHHHSHHHKPSVPGPLLNTPSASSTLTMSGASGTPISKHMVVPQKGAAAAHHNHHHHHHHNRPDLKLQQKHSNSTGPRDPNRDSSRQRISRDYQHQQQQQQQQQQQPPNYSQHQLSANNHIAAPKDSNSAPDIIDPVIPEISHVDKPSNNNHHSGSTRPVPFDKRSYDPRNKLIDHRKEEQKNSQYPNPPKYPEHIRSNDRLSRKLPELEQRSEEVRKLIEKPLPIPKPRAEIQKEEYIANMLKQSHNPNKYNQDSKLIHNSNRIFPHDLSKSQNLIKSHHQGQQLMHQGQQHQMSQIFKDKNGIQNPNLGIIDEKIDKRKHEELTQVPIIKHKSLFSPDKITPDINQRKSRQKTPPVLIKSIKQEEDLNTQLFSMSPELSLNLNIKKENQEQKIKSEDNLDKKRLPILSSGQPDSKEGLKLPTFETELMFNGLDIKPFKTETDLSPMKSAQGISALLQEPLAPMPSLLQTLSSDEGIFSQSGPLESSQNLQELPAVTASVPTGQKPLGSTQPNISQVSEEPFVSTVDISAFAAAPVISSVPIVQPAAQEAAVKKQEHHKSEKKKKKEKHKHKDKDKDKSKDKHKHKHKDKDKHRDKDKDKEGKDKKDGAEKRDKHEEAVTAAPIKITIPKDKLNLVDTPDSKKKSPSAGIKIKIPKERLKNKELPTAGHQGPLKIKIRTNTAASGQPEGYNVDNRKREREDSGGQPPAKKFQHVQGGQTGQTNAGQTGQPNQGQRGSDRQNGRHYTSNNKVRGDGNRIGQQLGRYPHSRLSNEHGFSKFVEQPIYQNPYFFTNFPPPIFNGQYFDPNFYFQYSQFNLYSQGNFSDNFEPLGIDTSEKHSTKDTKTSTSKLISQHQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HEJ9</accession>
    <name>A0A8J2HEJ9_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to UBFD1: Ubiquitin domain-containing protein UBFD1 (Homo sapiens)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS8243</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5096505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HEJ9"/>
    <dbReference type="OrthoDB" id="267397at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045296">
        <property type="term" value="F:cadherin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17047">
        <property type="entry name" value="Ubl_UBFD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039120">
        <property type="entry name" value="UBFD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057455">
        <property type="entry name" value="UBFD1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16470">
        <property type="entry name" value="UBIQUITIN DOMAIN-CONTAINING PROTEIN UBFD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16470:SF0">
        <property type="entry name" value="UBIQUITIN DOMAIN-CONTAINING PROTEIN UBFD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25343">
        <property type="entry name" value="PH_UBFD1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="2">
        <location>
            <begin position="51"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5096505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="287" mass="32028" checksum="4C3F2F371E164AC2" modified="2022-05-25" version="1">MDVDTEKVDGHENHSDNSSCSGAKLSEITNTNAVDKNKIEADEEEPSKTTENIDFKVIYNKKKIDITFPLDGLVIDLKTHLQKIISVPKEMQKVMIKGLAKDQDTLRSLGVTNGAKVMIVGSKLDDVLSVSVPNKQEVQDEAAEASSKEPLTQQKIHKKILDKGVPEDAMPGIINVKDPLPDCPLSGMLNKSGGKVRLTFKLEQDQLWIGTKERTDKISMSSIKGIHSEPIPEFPEYHIMGIQLGTTEASRYWIYWVPAQYIAAIKDAPMRAHSQIQITSHQWQEEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HEY6</accession>
    <name>A0A8J2HEY6_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">DNA/RNA non-specific endonuclease domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HICCMSTLAB_LOCUS7142</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA/RNA non-specific endonuclease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5093816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HEY6"/>
    <dbReference type="OrthoDB" id="5960141at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:RNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000014">
        <property type="term" value="F:single-stranded DNA endodeoxyribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006309">
        <property type="term" value="P:apoptotic DNA fragmentation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.570.10:FF:000007">
        <property type="entry name" value="Alkaline nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.570.10">
        <property type="entry name" value="Extracellular Endonuclease, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044929">
        <property type="entry name" value="DNA/RNA_non-sp_Endonuclease_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001604">
        <property type="entry name" value="Endo_G_ENPP1-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020821">
        <property type="entry name" value="ENPP1-3/EXOG-like_nuc-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044925">
        <property type="entry name" value="His-Me_finger_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040255">
        <property type="entry name" value="Non-specific_endonuclease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13966">
        <property type="entry name" value="ENDONUCLEASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13966:SF19">
        <property type="entry name" value="NUCLEASE EXOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01223">
        <property type="entry name" value="Endonuclease_NS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00892">
        <property type="entry name" value="Endonuclease_NS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00477">
        <property type="entry name" value="NUC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54060">
        <property type="entry name" value="His-Me finger endonucleases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA/RNA non-specific endonuclease/pyrophosphatase/phosphodiesterase" evidence="7">
        <location>
            <begin position="112"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="domain" description="ENPP1-3/EXOG-like endonuclease/phosphodiesterase" evidence="6">
        <location>
            <begin position="171"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="200"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="230"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR640255-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR640255-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG5093816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="371" mass="43106" checksum="975679B62985A022" modified="2022-05-25" version="1">MPLLLHPELHRGFIYTKEPGNRITVKVGDSIRVACPGGKIYFSRGKSYESTTLECIRDKTFLLTHDGGTEMFHQIYCNKYPQHSVRRISRGCKVGVTGEIGFSIRTDEQNEFIRILDFCHDEQLGQTIYAHALIPSVIDSAEISVPRPSFTKSGFFEGISMDNIYSRSHQQETLALILGSQKLANRYIHDRGNYFLSRGHLAAKLDFIFEAQQRATFYYVNTVPMWQNINDGNWEKIEKNVRNYASRRNRNLEVWTGSLGVLELEDFEGKMKKIYLNYHDEGRVAVPVPKLLFKVVYDRYRQAGVVFITVNNPHLNRLTGDYIVCEDICTEINFPEWDMRTERGYSYCCNIDDFRNAFPYLPEFKTRRLLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HF04</accession>
    <name>A0A8J2HF04_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="12">ATP-binding cassette transporter subfamily C member 7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HICCMSTLAB_LOCUS8811</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5097655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18579">
        <property type="entry name" value="ABC_6TM_ABCC_D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18580">
        <property type="entry name" value="ABC_6TM_ABCC_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03250">
        <property type="entry name" value="ABCC_MRP_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03244">
        <property type="entry name" value="ABCC_MRP_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000026">
        <property type="entry name" value="Multidrug resistance-associated protein lethal(2)03659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000163">
        <property type="entry name" value="Multidrug resistance-associated protein member 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000482">
        <property type="entry name" value="Multidrug resistance-associated protein member 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044746">
        <property type="entry name" value="ABCC_6TM_D1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044726">
        <property type="entry name" value="ABCC_6TM_D2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF415">
        <property type="entry name" value="FI20190P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="89"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="131"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="204"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="233"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="684"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="794"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="875"/>
            <end position="907"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="977"/>
            <end position="997"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1009"/>
            <end position="1027"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="11">
        <location>
            <begin position="94"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="408"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="11">
        <location>
            <begin position="794"/>
            <end position="1042"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="1073"/>
            <end position="1302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="634"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="634"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="646"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="657"/>
            <end position="666"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAG5097655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="1339" mass="150739" checksum="4FC9282E564C858D" modified="2022-05-25" version="1">MDSSKKYDNPNPRLTANIFSKLIFWWMNPLFLYGRTHDLQIKDLPNVLPDDRSEPLGDVLERNWKKEQDAAREEKRSPKLYTALKHTYLLSYSLFGFFIALCTAVRILQPYVMGLLIWHFDPRSDSSTSEAYTYASIVIFLSFVLGLLEHHMNSKQTEFGMRVRVACSSLVYRKMLKLSTPAANKIAGGQIMNLLSNDVARFDYLFMFLHYIWILPFQVVATGYLIWQSVQAAILAGIFFMAIQVIPLQMYLSKWTYKFRNKIAKRTDERVRLMAEIINGIQVIKMYTWEVPFQQLVSIARKYEIDILTIMSYLKGFNYATFVFTERITLYLTIMAFVLAGNSPSADIVFSIAQHLNRLQLTMAIYCPQAISAIAEGLVSVKRLEHFLLLEDNKPLMVSSAPADKSTVKIKDGTAAWEENSIVNTLHNINITINTGQLCALIGPVGAGKSSLLQLILGELPTNHGHVTVGGRVSYAGQQPWLFSGTVRNNILFGQPYDEARYRQVTRVCALIKDFVQLPQGDKTLVGERGAALSGGQQARINLARAVYRDADIYLLDDPLSAVDTHVGKSLFEDCIKGYLGNKTRILITHQVQYLKDVDLVVMLNNGVIEKQGSFAEFDEHRLKLMDTVTEKAERSPSVEKEITPSVDTSVVSNGLSEDESEEPEETQELMAKGNITKSLIWKYFRAGGSIMMLLVWISFTILGQIGSSGSDYWVAFWTTQEEIKFRIEANKILDNNSSSLKDNSKFYNETLNNLTSLDTSSNFDNETVDLINQTLKNAENFTSQEFYDRDTALYIYGILIALCVIMTTARNLLFYKICMNASKNLHNSMFACLLQAPMKFFNTTSSGKILNRFSKDIGCVDEQLPKFMVEAIQIYAVMLGIFIQIIIVHWWMSFLITIMILFYWVIKNIYLATAQDVKRLEGVTKSPVFTHVNSSMAGLTTIRSANSQELVRKEFDSYQDVHTSAFSTIVFSSAWFSFWLDAVTIVFVACTIYSFIIMDDDNTFAGPVGLVVSQILILCGMCQFGIRSTAEAMTQMTSVERVLQFTKLDKEGPFESDVNQKPAATWPSQGEIKFDHVYLKYSEEDAPVLKDLNVTFEAGMKVGIVGRTGAGKSSLISALFNLAKVDGNIYIDGVSTNKIGLYDLRSRLSIIPQEPILFSASLRDNLDPFHEYNDASIWAALEEVELKNAAPTLDYIVTQGGSNFSAGQRQLLCLARAIVRNNKILILDEATANVDPATDALIQKTIRSKFKDCTVLTIAHRLNTIMDSDKVLVMDNGRIVEFDHPHLLLKNKDGYFSKMLSETGKNMSDKLKLISEETFNNKATAGEPNQIVNGTPKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HFE4</accession>
    <name>A0A8J2HFE4_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Similar to Kif13a: Kinesin-like protein KIF13A (Mus musculus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">HICCMSTLAB_LOCUS8806</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5097645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3176171at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01365">
        <property type="entry name" value="KISc_KIF1A_KIF1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000010">
        <property type="entry name" value="Kinesin family member 13A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.190:FF:000014">
        <property type="entry name" value="Uncharacterized protein, isoform E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2520">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.190">
        <property type="entry name" value="CAP Gly-rich-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036859">
        <property type="entry name" value="CAP-Gly_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000938">
        <property type="entry name" value="CAP-Gly_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022164">
        <property type="entry name" value="Kinesin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022140">
        <property type="entry name" value="Kinesin-like_KIF1-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032405">
        <property type="entry name" value="Kinesin_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47117">
        <property type="entry name" value="STAR-RELATED LIPID TRANSFER PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01302">
        <property type="entry name" value="CAP_GLY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12473">
        <property type="entry name" value="DUF3694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12423">
        <property type="entry name" value="KIF1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16183">
        <property type="entry name" value="Kinesin_assoc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM01052">
        <property type="entry name" value="CAP_GLY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74924">
        <property type="entry name" value="Cap-Gly domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00845">
        <property type="entry name" value="CAP_GLY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50245">
        <property type="entry name" value="CAP_GLY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3" id="KW-0493">Microtubule</keyword>
    <keyword evidence="7 9" id="KW-0505">Motor protein</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="12">
        <location>
            <begin position="1"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="domain" description="CAP-Gly" evidence="13">
        <location>
            <begin position="1739"/>
            <end position="1781"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="781"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1335"/>
            <end position="1369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1388"/>
            <end position="1409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1527"/>
            <end position="1650"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1674"/>
            <end position="1707"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1831"/>
            <end position="1851"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="530"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1389"/>
            <end position="1398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="1399"/>
            <end position="1409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1542"/>
            <end position="1556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1603"/>
            <end position="1645"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="52"/>
            <end position="59"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="14">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CAG5097645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="1851" mass="206655" checksum="79B6373561C68C3F" modified="2022-05-25" version="1" fragment="single">NKPKTFAFDHCFFSLDPGGENFASQNVVFDALGRDILDNAFQGYNACIFAYGQTGSGKSYTMMGSGDNKGIIPRLCDNLFDMIAKQQSSELTYKVEVSYMEIYNEKVHDLLDPKPNKQSLKVREHNVLGPYVDGLSQLAVTAYQDIDNLMTEGNKSRTVAATNMNSESSRSHAVFSVILTQTLTDMRSGVSGEKVSRMSLVDLAGSERAVKTGAVGDRLKEGSNINKSLTTLGLVISKLADQSSGGKNRDKFVPYRDSVLTWLLKDNLGGNSKTVMVATISPAADNYEETLSTLRYADRAKRIVNHAVVNEDPNARIIRELRQEVEALKEMLLHATGQGLAVGQRRTDITEKISESEKLMKEMSVTWEEKLVKTERLQHERQHALEKMGISVQASGIQVEKNKFYLERTLVGGRSATTEQDIQLHGLGILPEHCVITIEDSALYMTPLNGARCFVNGSQVVEKTPLLHGDRIVWGNHHFFRVNCPRSATAISSEPQTPAQNIDYNFAKEELMLNELSNDPIQQAIARLERQHEEDKQVALEKQRLEYERQFQQLRNILSPSTPYSPYVPYDPLRGSHSGKLPACTPTTQMRVEKWAQERDEMFKRSLGQLKTDILKANSLVQEANFLAEEMDKQTKFSVTLQIPPYNLSPNRKRGAFVSEPAILVKRANMGSQVWTMEKLENKLIDMRDMYEEKKYNNNSLPRLPAVKDEVPGKTQDPFYESQENHNLIGVANIFLEVLFHDVRLDYHTPIISQQGEVAGRLQVEISRVSGQFPQDRICEAASETSGSDSGSSEHEDDTGTSQITCRVTIKQASGLPLSLSHFVFCQYTFWGHPEPIVVPPVVNSDLPVSNINTANNNSTNQRDSLTFQFNHTKDLTVPVTEEFMEHCSEGALSIEVWGHRSAGFSRSKPGWEVEQQLAKARSLADRWSELTRKIQLWVEIQELNEQGEYSPVEVVIKPDAMTGGVRVKPVQNSGTLPIICQSVLDIAVGSVSVRNRYQNPLDSYQDEDLNVLREKWSDALMRRRQYLDQHIQKLINKKNKTEQDVEREQSLVDQWVSLTEERNAVLVPAAGSGIPGAPADWNPPPGMEPHIPVLFLDLNADDLSTHQSGEEVSITGLNSIISKEHGNKFFTLPIIRHLEKDVCAIAAWDSSIHDDLHLNRATDTNERVFLILKTTVRLSHPAQMDLVLRKRLALNIYKKQSLADKLFKRIVRTDCLTQTGVTYEVVSNIPKASEELEDRESLAQIAASGEDSGLCDGETYIEKYTRGVSAVESILTLDRLRQNVAVKELLQAQGQPLMRKTASVPNFSQIMRFDTSMEALSVTRSESVTDLNSELNGLPHPRRASVGHARNDDSPFNTTPLKPFGIASPNMTGKLGLRMTTLHEEISHTGNHPSSPIQDDDEEKSDVDYSEYEAYKAPTKFVKPLTTSRTLDSLAELQSTKINTPSMSSSGYGSQAVSTTNLTSDDSMSIKSISVDETPDLEYRNIMEYKKPEKMDSSLVEETPEEYLGEINTDIENLSVSQRITEDVDQSDVQPEINKRFSSSSSLFSKNDSNSIADKRNEMEISQASSDDSPLEDNSIVNTKLPPGKVVRRRKQSSGSANNSRTPTLTSNSNSNININNNNNHNNTNANNNNNNNNNNNNNNQHRASFPMVRPHFSESKVAAQLEHILHQPDMGYENGDNSSSAERIDDDMSDKNSGFGSRHDLTRIEPPLPDWVVVGESVMVRPYSYCGVIAYIGPTEFASGTWIGVELDAPTGKNDGAVSGQRYFTCRPKCGIFVKVDKLIQDRRGRALRSFIKQESAPPPSSTMRRSVKVYTHCIEAEVAVKASQQPAPDIRRVENEATGINSPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HFG2</accession>
    <name>A0A8J2HFG2_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to PTPRM: Receptor-type tyrosine-protein phosphatase mu (Homo sapiens)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS8785</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5097603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HFG2"/>
    <dbReference type="OrthoDB" id="6144703at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009653">
        <property type="term" value="P:anatomical structure morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048666">
        <property type="term" value="P:neuron development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00047">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.10:FF:000062">
        <property type="entry name" value="Receptor-type tyrosine-protein phosphatase kappa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.10:FF:000070">
        <property type="entry name" value="Receptor-type tyrosine-protein phosphatase kappa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050348">
        <property type="entry name" value="Protein-Tyr_Phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000242">
        <property type="entry name" value="PTP_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19134:SF561">
        <property type="entry name" value="PROTEIN TYROSINE PHOSPHATASE 36E, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19134">
        <property type="entry name" value="RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00102">
        <property type="entry name" value="Y_phosphatase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00700">
        <property type="entry name" value="PRTYPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00194">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50055">
        <property type="entry name" value="TYR_PHOSPHATASE_PTP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0675">Receptor</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="2">
        <location>
            <begin position="178"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="1">
        <location>
            <begin position="294"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="2">
        <location>
            <begin position="482"/>
            <end position="557"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5097603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="560" mass="64396" checksum="16563A386C4BEB92" modified="2022-05-25" version="1">MGSSADKVETHLCRHAMKPSNREKNQNQRCIPYDYNRVVLDTIEGQTDSDYINASYVDSLLKPNAYIVTQGPIETTVTEFWRMVWQERASCIVMLTKTFDFIKVMCVQYWPANKDKDEEYGGICVSVLKEEELANFHIRTIKLYKKNANEEITEERTLLQFHYTEWHSHTCPFSNAVLEFRRRVRAVVGSTIKNESGPMVVHCNDGGGRSGVYLAIDANMELAEEEDTFDVFGYLKKLRQSRRGLIESLDQYKFVYDTLEEFVICGASWFPVSELSQRLKQKSVKNPITKMNEYQREYQQICKQTPRFTIGDCAGGHRADNREKNRDVLVVPPDNFRPYLTSFQGNSFTDYINAVFVDGYTKPREYIVTEWPLKHTCGEFWSLVYDYECSAVVILCVPPTTSTNFPSFWPEGKHSKKYGPVFTIDHISHNHYTNIKTWIFRINKKIVSLTELMAGVKAPPKTVQLFQLTCWPMGQAVPTSTNSLVELMNMVERWRQKGDYGPVCVVSPDGRSRCGVYCAANACIEQVIQHGEVDIFQAVKTVRRHRPQLVGNMGQPHFGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HG23</accession>
    <name>A0A8J2HG23_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS7476</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5094972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HG23"/>
    <dbReference type="OrthoDB" id="10416085at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035247660" description="Secreted protein" evidence="1">
        <location>
            <begin position="18"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5094972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="112" mass="12957" checksum="F32B255FA6402C50" modified="2022-05-25" version="1">MILVLLLLSSVLTVACSEILSIEDYSILDNVNAANEQEKEYDDESFIDDGLRFRQEAEDNEPLRNNEPFEDDDVNLQTHAAIRSANADDDCDLRQSERLDYFDYRKFCEGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HGE4</accession>
    <name>A0A8J2HGE4_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS7387</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5094061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HGE4"/>
    <dbReference type="OrthoDB" id="8249012at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21521">
        <property type="entry name" value="AMUN, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21521:SF0">
        <property type="entry name" value="AMUN, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="218"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="266"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="296"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5094061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="334" mass="37052" checksum="44DC48F4FB6F23E3" modified="2022-05-25" version="1">MASVRDTATFFLEGTASQFEHVIKLYPQALRLKADRKNKKPEELIKLDNWYQNELPKKIKSRGKDAHLNHEELVQTMKWKQTRGKFYPQLSYLVKVNTPRAVMAETKKAFKKLPNLEQAITALSNLKGVGTTMASALLAAASPEHAPFMADECLMAIPEIEGIDYTTKEYLNFVQHIQTTVERLNQQTTNGKTWSPHRVELALWTHYIASEMKPELLDGIPGVTENGKTHSSSNGDATEPSDDSNQDAAVVNGKEPATIDPAAIDENSTTTSFTEDSMDKPATPITAAVASEDTNDSLTTNENEDCSNTSRPTDSEDTEDSQDAQEPPIKKIKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HGP3</accession>
    <name>A0A8J2HGP3_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">Guanine deaminase</fullName>
            <shortName evidence="9">Guanase</shortName>
            <ecNumber evidence="3 9">3.5.4.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Guanine aminohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HICCMSTLAB_LOCUS7299</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the hydrolytic deamination of guanine, producing xanthine and ammonia.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>guanine + H2O + H(+) = xanthine + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:14665"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16235"/>
            <dbReference type="ChEBI" id="CHEBI:17712"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="EC" id="3.5.4.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="9">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 9">Purine metabolism; guanine degradation; xanthine from guanine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the metallo-dependent hydrolases superfamily. ATZ/TRZ family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.3" evidence="3 9"/>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5093973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HGP3"/>
    <dbReference type="OrthoDB" id="194468at2759"/>
    <dbReference type="UniPathway" id="UPA00603">
        <property type="reaction ID" value="UER00660"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008892">
        <property type="term" value="F:guanine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006147">
        <property type="term" value="P:guanine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.140:FF:000022">
        <property type="entry name" value="Guanine deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="entry name" value="Urease, subunit C, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014311">
        <property type="entry name" value="Guanine_deaminase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051607">
        <property type="entry name" value="Metallo-dep_hydrolases"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02967">
        <property type="entry name" value="guan_deamin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11271">
        <property type="entry name" value="GUANINE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11271:SF6">
        <property type="entry name" value="GUANINE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="Composite domain of metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="10">
        <location>
            <begin position="66"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00051148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU366009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAG5093973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="444" mass="49699" checksum="097C1000B85973B3" modified="2022-05-25" version="1">MTSPKYLFIGPIVQTIKSGASIELQIIEKAGIVVQDGQILEIINRPNKSEIKADNITILEKGQFFTPGFIDCHVHAVQLPNIGLGYDKSLLDWLEAYTFPLELQFSDNSFAEKVFEAVVIYLSRIFKQKRTLSLGTTTACYFASLYNEASLILAEKAVKYHQRAFVGKLNMDRVRDDDYYERTDISVDNTRKFIDDVYKLKSSLVNPVITPRFALSCSMKLLKHLGEIAKENNLLVQTHVCENTGEIEECKSLFPDCPTYMSVYEQANLLTNKTVLAHGVFLEDSELKILAKHNSSIIHCPSSNTFLRSGLCDIQRLRRNNITVGLGTDVAGGNFMCMLDVMRSALEVSNHIGFIQGDSYKPIDFVDAFYLATLGGAEALSIDSQVGNLIAGKKFDALVIDLQAKDSPLDNLKNLTLKEQLQRLIYSGDDRNIVNVYVEGHKVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HIF5</accession>
    <name>A0A8J2HIF5_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Amino acid transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HICCMSTLAB_LOCUS10831</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Membrane</location>
            <topology evidence="1 7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5102070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HIF5"/>
    <dbReference type="OrthoDB" id="5877963at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015501">
        <property type="term" value="F:glutamate:sodium symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005313">
        <property type="term" value="F:L-glutamate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015175">
        <property type="term" value="F:neutral L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3860.10">
        <property type="entry name" value="Sodium:dicarboxylate symporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050746">
        <property type="entry name" value="DAACS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001991">
        <property type="entry name" value="Na-dicarboxylate_symporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036458">
        <property type="entry name" value="Na:dicarbo_symporter_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11958:SF111">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11958">
        <property type="entry name" value="SODIUM/DICARBOXYLATE SYMPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00375">
        <property type="entry name" value="SDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00173">
        <property type="entry name" value="EDTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118215">
        <property type="entry name" value="Proton glutamate symport protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0769">Symport</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="46"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="81"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="177"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="214"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="248"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="322"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="359"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG5102070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="411" mass="44725" checksum="3FF1E80D5BB7FCFB" modified="2022-05-25" version="1">MNENRLTILTLTGVMCGVIIGVILKNYSNRQWSERDIMYFQFPGEIFLRIINCLVLPLIISSVVSASCYLSKSGSIGLKAFYYYCTTTSLGIILAVTLVQTIKPGEFYVNRNTTVSNHIKKSVTADAFLDLLRNLFTDNLIKASLSQTQITSPLNSTNDENINSWEIHHRDNDGTNVLGIVGFCLVLGIAIGHLEEKGKPLNDFFKSLSDTVMLMMDWVIMIVPAAVLFLIPGKILEAENITLMISNLGLYVLVVFAGLFIHSLIVLPLLYFICTRKSPYSLLLKTGPAIITALGTSSSTATVPMTIKCLNRIGVNPKVSQFIAPIGATINMDGIALYETIGALFIIQQRGLDFSLMQIISIAITCTVSCIGAAGLPSGGYVMLIVVLESIGIPAEDIDTNIPDNKTPAAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HIJ4</accession>
    <name>A0A8J2HIJ4_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similar to pen-2: Gamma-secretase subunit pen-2 (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS10907</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5102222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HIJ4"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019379">
        <property type="entry name" value="Gamma_Secretase_Asp_P_PEN2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10251">
        <property type="entry name" value="PEN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="23"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5102222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="67" mass="7407" checksum="5685934F8122718F" modified="2022-05-25" version="1">MDGMHIQNNGLHALQTLLTLRDVIFSGIGAVIWAAVLLAWVIIFQTQRAVWGEFADTISYIIPEGIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HK44</accession>
    <name>A0A8J2HK44_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Similar to AAEL010953: Protein OPI10 homolog (Aedes aegypti)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HICCMSTLAB_LOCUS11952</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the OPI10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5104338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HK44"/>
    <dbReference type="OrthoDB" id="10248398at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030544">
        <property type="term" value="F:Hsp70 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061608">
        <property type="term" value="F:nuclear import signal receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048364">
        <property type="entry name" value="Hikeshi-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008493">
        <property type="entry name" value="Hikeshi-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031318">
        <property type="entry name" value="OPI10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12925">
        <property type="entry name" value="HIKESHI FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12925:SF0">
        <property type="entry name" value="PROTEIN HIKESHI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21057">
        <property type="entry name" value="Hikeshi-like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05603">
        <property type="entry name" value="Hikeshi-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hikeshi-like N-terminal" evidence="2">
        <location>
            <begin position="5"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="domain" description="Hikeshi-like C-terminal" evidence="3">
        <location>
            <begin position="107"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF21057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG5104338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="167" mass="18750" checksum="770DFEC3A8ACBE21" modified="2022-05-25" version="1">MLGIIVSGRLVQTDFQQISENQFLINVPDADNVNHIVIFLTGYISNNKPSAIFRISDLKKNHEFENANLGIFGAKISHSAQIGISVEPLSAIEPLSALVASTTTESHVKFAQKMIINFMNYVSSFSVTQSQMTPNPSENFVPLSSVQGWYETFERRLQQNPNFWKQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HK91</accession>
    <name>A0A8J2HK91_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Similar to Cidec: Cell death activator CIDE-3 (Rattus norvegicus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">HICCMSTLAB_LOCUS10110</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5101037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HK91"/>
    <dbReference type="OrthoDB" id="6475906at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042981">
        <property type="term" value="P:regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01615">
        <property type="entry name" value="CIDE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003508">
        <property type="entry name" value="CIDE-N_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12306">
        <property type="entry name" value="CELL DEATH ACTIVATOR CIDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12306:SF15">
        <property type="entry name" value="DNAATION FACTOR-RELATED PROTEIN 1, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02017">
        <property type="entry name" value="CIDE-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00266">
        <property type="entry name" value="CAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54277">
        <property type="entry name" value="CAD &amp; PB1 domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51135">
        <property type="entry name" value="CIDE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CIDE-N" evidence="4">
        <location>
            <begin position="26"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="10"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAG5101037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="219" mass="23978" checksum="0763642280AE2C01" modified="2022-05-25" version="1">MSSLECGWVKNSSKMSEGNSAVTTVTGNPYKIVDCSREKRKGITAASLEDLTNVARSRLALPTDADITIVLEQDGTEVDDEEYFATLERNTSLMVLNGSEKWAAPGSAKTATSRYILVDNVDSAGRTEESTTRGNYHRPIEPLVSSLHNDPTHISLLGGNDLELLSDMNPDSLADIVPDRMFLEQLKEASGRFLAEKRQAQESMALLQMYASSGEMERA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HKC5</accession>
    <name>A0A8J2HKC5_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Similar to TBC1D19: TBC1 domain family member 19 (Homo sapiens)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS11790</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5103999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HKC5"/>
    <dbReference type="OrthoDB" id="10249775at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042507">
        <property type="entry name" value="TBC1D19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16110">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16110:SF1">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5103999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="477" mass="54515" checksum="6CE7944B1DDD8938" modified="2022-05-25" version="1">MINNENIDDTAKKLTKEIQCMSNYKNLYNEIQRIVASSAVKKDNFKSTLLEALKNNGGPLQSSEEKKSNVDLNYLKKAQIQWERRIHKSLNSMCNELNIPLARIRPSADKDELTDKWNELSTFDIDLSSYRPLYAPKDFLEVLFSVHDPAVKKQINEPKWEFSHIQIQVKTLEQLRTTYAELAQGVALLGVNNDMPAAGKFVNLEAERTDFGEKVLSSNHAPIAQEFLKRGAPRALRGRLWSLVLGSVVKDSDRKYYEELKELVLQYDIMVDKLIIKDVQLTASNDDQYFVFEDVLYKTMLCFSRDSEVLAPVTTDRSAGGQVIHAILQGKPAALENTLVFPPSGVIPFHGFTMYATPFCYLYDDPCSMYFTFRAFYLRYWLRLHTVSSHEQGIVALCLLFERLLHGHLPPEQLLYLWDLILGYDSLEIIPLLAVTILSFRKENLLQVNNLVNVEAILADLSSLKVMPLLQLALLKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HKE2</accession>
    <name>A0A8J2HKE2_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Similar to creld2: Cysteine-rich with EGF-like domain protein 2 (Danio rerio)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HICCMSTLAB_LOCUS7367</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CRELD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5094041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HKE2"/>
    <dbReference type="OrthoDB" id="19903at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048513">
        <property type="term" value="P:animal organ development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048731">
        <property type="term" value="P:system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021852">
        <property type="entry name" value="DUF3456"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018097">
        <property type="entry name" value="EGF_Ca-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006212">
        <property type="entry name" value="Furin_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002049">
        <property type="entry name" value="LE_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11938">
        <property type="entry name" value="DUF3456"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00261">
        <property type="entry name" value="FU"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01187">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01248">
        <property type="entry name" value="EGF_LAM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="4 5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2 5" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035256368" evidence="7">
        <location>
            <begin position="24"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="346"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="8">
        <location>
            <begin position="152"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="184"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAG5094041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="383" mass="42707" checksum="D798B30931D6BF85" modified="2022-05-25" version="1">MKYIKFILLLLTLTSCLIIYSTASLQPPTDVKAEKLRSERLPDCAACRVLIESFQKGIEKTKRGKFEGGDTAWEEDNQKSYARSEVRLTEIQENLCKDITRGEIQCQELAEDLETAIEEWWFKHQDLHPDIFAYICVDFTARCCQKDRWGKDCSECPGYPDNVCGNNGKCRGAGTRKGNGTCHCDKGYTGEHCSECDKKYYQSYKDETKLLCSSCHEACVDGCTGAGSADCQGQCKKGWVVDQEKGGCADVNECVKSDKYCPGNQFCVNKDGGYSCLKCDRACNGCIADGPDMCVKCADDYEKKDNICINPDILGRKQRENWARYATYFGLCLATYIILQGNVYAASAIGLMVALYISVSEYMIANTNVQDTTPNVDFLPPTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HKK6</accession>
    <name>A0A8J2HKK6_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Odorant receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HICCMSTLAB_LOCUS10007</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Cell membrane</location>
            <topology evidence="1 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the insect chemoreceptor superfamily. Heteromeric odorant receptor channel (TC 1.A.69) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5100934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HKK6"/>
    <dbReference type="OrthoDB" id="7539170at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005549">
        <property type="term" value="F:odorant binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004984">
        <property type="term" value="F:olfactory receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004117">
        <property type="entry name" value="7tm6_olfct_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21137">
        <property type="entry name" value="ODORANT RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21137:SF35">
        <property type="entry name" value="ODORANT RECEPTOR 19A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02949">
        <property type="entry name" value="7tm_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 10" id="KW-0552">Olfaction</keyword>
    <keyword evidence="8 10 11" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="9 10" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="40"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="71"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="128"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="188"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="266"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="301"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="370"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU351113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAG5100934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="397" mass="45361" checksum="057D8D67D6F8E89C" modified="2022-05-25" version="1">MKNSTMINENYALQINRWCLESLGIWQFVMKSSYFAKITAVFLIIICTFLLGFIIIPGILFAFVLIKDPAIRLQVSGVLSFCVMGIMKYYYLNLKKGQISDCINHLISDWKKISNYDDKMIMISYAKFGRYSSILSAIFMYASSVFYAGILPFMSPGMKNEDNITMRNLAYPCHFIIFDEHESPAYEIVFFIQCCCSFVMASITNGACNLATVFIMHACGQLEILTSWLNNTRNNDRKSKDMYSKYSAVIEQHATTLRFINKVEKLFQQICFVEVVGCTLNICLLGYYTLIGWSQNDTGGVVTYLLLLTSFVYNIFLYCYMGEMLTQKCQGVSNVVYLTDWYDLPVKLARGFILSIVIAQNYEPLKAGKLIFLSINTFGTVIRTSVAYLNILRTFMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HKS3</accession>
    <name>A0A8J2HKS3_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS9462</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5100255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HKS3"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5100255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="214" mass="23377" checksum="7E2E502A0D5A8261" modified="2022-05-25" version="1">MVAFHQRWVRYSNNVISSRSNYLNDKNIHLEEACRLKVLLISVPVQRKSNSAWNSGLLQTVQRKPGNPSNKHTRCVLTWDVSSPSASASRCWRLIFSVSSSPFSPRLWYPESRTTRRARGNNSSRLVRRAGTNRQICAAASFTDTSWSVSGFGSNGLKLQASLSAASASRCTCDGNNVGVTCVGLGGAPPPPLGLGVVPLPQDDSQVPTLNHYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HKY7</accession>
    <name>A0A8J2HKY7_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cell division cycle protein 27 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HICCMSTLAB_LOCUS11007</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the APC3/CDC27 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5102422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HKY7"/>
    <dbReference type="OrthoDB" id="329563at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007091">
        <property type="term" value="P:metaphase/anaphase transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000018">
        <property type="entry name" value="Cell division cycle protein 27 homolog B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12558">
        <property type="entry name" value="CELL DIVISION CYCLE 16,23,27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12558:SF13">
        <property type="entry name" value="CELL DIVISION CYCLE PROTEIN 27 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00515">
        <property type="entry name" value="TPR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13174">
        <property type="entry name" value="TPR_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50293">
        <property type="entry name" value="TPR_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="9" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 7" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="7">
        <location>
            <begin position="341"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="7">
        <location>
            <begin position="409"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="7">
        <location>
            <begin position="443"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="7">
        <location>
            <begin position="477"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="7">
        <location>
            <begin position="579"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="138"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="625"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="149"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="186"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="221"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="233"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="246"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="260"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="637"/>
            <end position="647"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00039307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAG5102422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="680" mass="75732" checksum="BE9BE5610811C244" modified="2022-05-25" version="1">MCHGTNQLNYISEPDVILPNTPTPNINMTPTQAVIVNGNNQGARLHPSIEESPQPQAIFYTNLSTISPRSKPQRYRSMFSNSMSPLTPSFGILPLDNNTPEPTVLPSLVTLTESNDQKSLAKRVSSLRAHVGQFMSRKETPLQQGKPVFSQSGNTSNTANIVTVTPTTPTPAAPTLQGPNVRRSSRLFSHSYSVKENNKSPNRNKFTTPKSPSRKTKARLSKTNLNKATFNELNERNRSDKEKSETITSEKMVATTNALNQNSNTNNNNNNSSNNNSNNNNSNSNCATQQQCAVLVQKQCAEGLMSLLRELGLAYQHLSQFNCSQAVEILSVLPKHHYNTGWVLSMLARAHFEMNDYKKAANYFAEVRQLEPQRMDLMEIYSTVLWHLHSEVQLSTLAQELVAEDRSSPAAWCATGNLFSAQTEHETAIKFFQRAIQVDPNFPYAYTLLGHEYVLTEELEKAVHAFRNAIRLDPRHYNAWFGLGTIYSKQEQYSLAEVHFKRALQINPYHSAIMCHIGVVQHALKKTDLALRTLNVAITNAPDNTLCKFHRASINFSIGRYNEALREFEELKNIAPKESLVYYSIGKVHKKLGNTHLALMYFSWATDLDPKGVNSQIKEAILSPGQGDEETPVANPGNEQQGQNITQHETEGGGELTAEVSGLASTISVVTNQDDSDDSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HL35</accession>
    <name>A0A8J2HL35_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Integrin alpha PS4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">HICCMSTLAB_LOCUS12465</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Membrane</location>
            <topology evidence="1 13">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the integrin alpha chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5106848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HL35"/>
    <dbReference type="OrthoDB" id="5573735at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009897">
        <property type="term" value="C:external side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008305">
        <property type="term" value="C:integrin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005178">
        <property type="term" value="F:integrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033627">
        <property type="term" value="P:cell adhesion mediated by integrin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007160">
        <property type="term" value="P:cell-matrix adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007157">
        <property type="term" value="P:heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007229">
        <property type="term" value="P:integrin-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.930">
        <property type="entry name" value="Bicelle-embedded integrin alpha(iib) transmembrane segment"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.130">
        <property type="entry name" value="Integrin alpha, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1460">
        <property type="entry name" value="Integrin domains. Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1510">
        <property type="entry name" value="ntegrin, alpha v. Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013517">
        <property type="entry name" value="FG-GAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013519">
        <property type="entry name" value="Int_alpha_beta-p"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000413">
        <property type="entry name" value="Integrin_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048285">
        <property type="entry name" value="Integrin_alpha_Ig-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028994">
        <property type="entry name" value="Integrin_alpha_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032695">
        <property type="entry name" value="Integrin_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23220">
        <property type="entry name" value="INTEGRIN ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23220:SF83">
        <property type="entry name" value="INTEGRIN ALPHA-PS3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01839">
        <property type="entry name" value="FG-GAP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20805">
        <property type="entry name" value="Integrin_A_Ig_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01185">
        <property type="entry name" value="INTEGRINA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00191">
        <property type="entry name" value="Int_alpha"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69318">
        <property type="entry name" value="Integrin alpha N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69179">
        <property type="entry name" value="Integrin domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51470">
        <property type="entry name" value="FG_GAP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 13" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 13 15" id="KW-0401">Integrin</keyword>
    <keyword evidence="9 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="10 13" id="KW-0675">Receptor</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="757"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="repeat" description="FG-GAP" evidence="12">
        <location>
            <begin position="152"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="repeat" description="FG-GAP" evidence="12">
        <location>
            <begin position="211"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="repeat" description="FG-GAP" evidence="12">
        <location>
            <begin position="272"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="domain" description="Integrin alpha second immunoglobulin-like" evidence="14">
        <location>
            <begin position="440"/>
            <end position="564"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF20805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CAG5106848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="806" mass="90346" checksum="7BC475BC4F492164" modified="2022-05-25" version="1">MNGLCYYSKIDTPDKFNRTNDIWIKSMTDYHLQTSRAKNGQVYYHYGMGQLGMSMHEFHTDGSWNIMLGSPGAFSWYGTPVVVTEGRSGVFRSVVPSYDITNYEYLGTRYSVTSGHYFGLSRRYFAAGAPRNDDMKGRVLVFSYDVDEKKLIIKNILTGTQHGEYFGSAITSCDVDGDGDDELIVGAPLWSKSGDEGRIYIFHNRYYSYMELSSSIDGTVENGRFGSSVMCLGDIDNDGYQDIAVGAPYENDHGAVFIFNGQQKGLSTTWSQKITGDQFPETLKGFGISISEPRDVDGNGYPDFAVGSFKSSQAVLFRSHSVIHVNIDVDLDDNFKLETNSSSFFIKVCCSYDGIRAPDSIRIIKQLTIDPMEGLKILLQENLINVFDPIEIKASIILDTPEIDNQNPESRDNFCHNCPVINKLRSKTEDIIKLPFAVDCGPDDVCRSNITLDVTTNLEGNRYIIGTRQAINVSINVNNYGEGAYHAYLNIFLPIFLTLASVPLNCDEHTKDNGELIVCSIGNPLKDNQTVLLEIDVMVNSDQKQTNLEISVDTQSENINYDNNTMRFDHIYEVRKFGVTSIEQAILKVLIPTHLMDGDNMIDIATINRTELSLPKTIINRHNSFCSNGTIEDHTEFKYNNYSIEKINIKDNFVNVLTDDRTFYVNCSNPLIICTAIYCVLQTPLNLSTVAEIKFTMDLKIKNLRENILEEKDIVYFVSSGHVNISLPEGILQINNINSDHVAIGTTFVGSPIAKPVAVWIIAFSVVLGIILLIILIIVLVKIGFFNRRKKEELEALKADDNVSIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HLP1</accession>
    <name>A0A8J2HLP1_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS10672</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5101771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HLP1"/>
    <dbReference type="OrthoDB" id="6819088at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5101771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="180" mass="21116" checksum="FB0873C1CE70C06F" modified="2022-05-25" version="1">MKSVAKTSKNRKRRQRHPRKNKSDSEDTEGSILPQDSQYSGSTETEGEAKEDSALPPSMNFFDALRFYRHLLNPVPMVIGEMLYQQPMTREESYRLRRPLGGMVTKNKQPRVMYNQRNILNLEANLRNFNWQFTWKFDQDVSTRVSSKGQLDEDLNCDELTCCSYCDFEEPIQSDFIKEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HLZ7</accession>
    <name>A0A8J2HLZ7_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">aralkylamine N-acetyltransferase</fullName>
            <ecNumber evidence="5">2.3.1.87</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">HICCMSTLAB_LOCUS10593</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>dopamine + (9Z)-octadecenoyl-CoA = N-(9Z-octadecanoyl)-dopamine + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:51380"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:31883"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57387"/>
            <dbReference type="ChEBI" id="CHEBI:59905"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:51381"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>dopamine + acetyl-CoA = N-acetyldopamine + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:51388"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:59905"/>
            <dbReference type="ChEBI" id="CHEBI:125678"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:51389"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>dopamine + hexadecanoyl-CoA = N-hexadecanoyl-dopamine + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:51376"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:59905"/>
            <dbReference type="ChEBI" id="CHEBI:134058"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:51377"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>serotonin + (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA = N-[(5Z,8Z,11Z,14Z)-eicosatetraenoyl]-serotonin + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:51396"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57368"/>
            <dbReference type="ChEBI" id="CHEBI:132255"/>
            <dbReference type="ChEBI" id="CHEBI:350546"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:51397"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>serotonin + (9Z)-octadecenoyl-CoA = N-(9Z-octadecenoyl)-serotonin + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:51392"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57387"/>
            <dbReference type="ChEBI" id="CHEBI:134064"/>
            <dbReference type="ChEBI" id="CHEBI:350546"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:51393"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>serotonin + acetyl-CoA = N-acetylserotonin + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:25217"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17697"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:350546"/>
            <dbReference type="EC" id="2.3.1.87"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:25218"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>serotonin + hexadecanoyl-CoA = N-hexadecanoyl-serotonin + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:51384"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:134059"/>
            <dbReference type="ChEBI" id="CHEBI:350546"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:51385"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>serotonin + octadecanoyl-CoA = N-octadecanoyl-serotonin + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:51400"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57394"/>
            <dbReference type="ChEBI" id="CHEBI:134065"/>
            <dbReference type="ChEBI" id="CHEBI:350546"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:51401"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Aromatic compound metabolism; melatonin biosynthesis; melatonin from serotonin: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the acetyltransferase family. AANAT subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.87" evidence="5"/>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5101691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HLZ7"/>
    <dbReference type="OrthoDB" id="41532at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004059">
        <property type="term" value="F:aralkylamine N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000046">
        <property type="entry name" value="Dopamine N-acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20905:SF1">
        <property type="entry name" value="AT07410P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20905">
        <property type="entry name" value="N-ACETYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="14">
        <location>
            <begin position="174"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00037926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00039114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00050189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00050849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00051284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00051711"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00051823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00052178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00052335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00052491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CAG5101691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="260" mass="29406" checksum="6AD80AE181340780" modified="2022-05-25" version="1">MAQVISGKLTNTHISTVGFTNNEDYVKHKKLTRYSLADTMDEAPRDYSIQVIKQEDKPEVLKFLRRFFFRDEPLNASIELIPRGENSTCVPLEEYSMSSIDENLSLKAVSSAGNIVGVQLNGTTVKPEDTDEPDFIKNCDNFKFKKILRLLHHVDRKAAVLDRYPGSKILDVKIISVDSGCRGKGIAAALCQKTVDIAKELNYNYIRTDASSHYTAKLCKRLGFEQIFELMYKDYVDSNGKSIFTPAYPHSCISTFIKKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HM16</accession>
    <name>A0A8J2HM16_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Similar to NCOA7: Nuclear receptor coactivator 7 (Gallus gallus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS8580</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001121">
        <property type="protein sequence ID" value="CAG5097177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HM16"/>
    <dbReference type="OrthoDB" id="26679at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00118">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="entry name" value="LysM domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01476">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00257">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54106">
        <property type="entry name" value="LysM domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51782">
        <property type="entry name" value="LYSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0675">Receptor</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LysM" evidence="2">
        <location>
            <begin position="14"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="217"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="397"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="447"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="494"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="217"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="230"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="273"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="419"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="452"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5097177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="598" mass="66646" checksum="ABD221B4C336BCAD" modified="2022-05-25" version="1">MNLASVYSQVSLTFMIHVGNRDTLTSVAARFDTTPSELSKLNRLGSTFIYPGQQLWVPIKGEARLGAAMDEDEPAYRERFLKINVRHITDGQGVVGGVLLVTPNAVMFDPNVSDPLVIEHGAESYGVIAPMEFVVNAAIYYDIAHMRVSHTDAMSSDKKPEIYYMKKPERSDARKCLSPGKDDNFSELAGDDNESVCSCAEREGDAFPKAFERDLVTPTNLQSDEGANSGKDKDKDKDKDREDKDKDKDKDKDKDKLDETAEKDLCVGQSSRTLEERRRSMLDHHWAVPSKDRCSFSVDDEQQDSINSDKSQPEPAKPIAIPEGEDGSLVKLSCYDSGIDIREPNPPLPVVQPIPSKKKYSDADIVLSTDWVPPITIAPTNVSSGSALDVLSVVNGGGRKKASSVSFSLDSNAEEPEKDEEHKDEDKQETRRNKMLKRLSYPLSWMEGLTGDSKDEENKTVPEKVPSLPNSADSHHSSVFSKVFSRRSSVGTFIRQQPLTSSGSSSVDSTRGNKTSTAPPRLDYRSMVSVDDMPELFVSFDKLIPRPARSCEDPPLYLRLRTGRPKDKKIPRSTPIMSYGKKKLRPEYWFSVPRNRKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HMK2</accession>
    <name>A0A8J2HMK2_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Similar to ING4: Inhibitor of growth protein 4 (Gallus gallus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HICCMSTLAB_LOCUS11727</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5103873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HMK2"/>
    <dbReference type="OrthoDB" id="5411773at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16859">
        <property type="entry name" value="ING_ING4_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028651">
        <property type="entry name" value="ING_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024610">
        <property type="entry name" value="ING_N_histone-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10333">
        <property type="entry name" value="INHIBITOR OF GROWTH PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10333:SF42">
        <property type="entry name" value="INHIBITOR OF GROWTH PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12998">
        <property type="entry name" value="ING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01408">
        <property type="entry name" value="ING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Inhibitor of growth protein N-terminal histone-binding" evidence="3">
        <location>
            <begin position="6"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="120"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="129"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="167"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG5103873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="242" mass="27217" checksum="F0F01CD23594D1DB" modified="2022-05-25" version="1">MTTALYLEHYLDSLEHLPIELQRNFGLMRDLDTRAQGLMKDIDKLADDYLKNIKKDSSEKNEGQLLHIQNLFSKAKEYGDDKVQLAIQTYELVDKHIRRLDSDLARFEAEIQDKALNNNRVAEESGASKKGRKKSLKEKEKRKKGTAGASSEDESKSIRKKQKKGGSVSSATTGAVGSGAQTDASLGHPADVLDMPVDPNEPTYCLCHQCPIEWFHFSCVGLTTKPKGKWYCPKCTQDRKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HML5</accession>
    <name>A0A8J2HML5_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Similar to rst: Irregular chiasm C-roughest protein (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HICCMSTLAB_LOCUS10430</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5101357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HML5"/>
    <dbReference type="OrthoDB" id="6413693at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005911">
        <property type="term" value="C:cell-cell junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050839">
        <property type="term" value="F:cell adhesion molecule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098609">
        <property type="term" value="P:cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000077">
        <property type="entry name" value="Kirre like nephrin family adhesion molecule 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013162">
        <property type="entry name" value="CD80_C2-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051275">
        <property type="entry name" value="Cell_adhesion_signaling"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11640:SF31">
        <property type="entry name" value="IRREGULAR CHIASM C-ROUGHEST PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11640">
        <property type="entry name" value="NEPHRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08205">
        <property type="entry name" value="C2-set_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13895">
        <property type="entry name" value="Ig_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="6 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="524"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="12">
        <location>
            <begin position="28"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="12">
        <location>
            <begin position="143"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="12">
        <location>
            <begin position="245"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="12">
        <location>
            <begin position="336"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="12">
        <location>
            <begin position="420"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="557"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="575"/>
            <end position="584"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAG5101357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="806" mass="88428" checksum="17C5548E38551455" modified="2022-05-25" version="1">MTICCWMTITVRSTVATNSSAGPSTLRPATTEIVYQRFAIEPQDQTAVIGSRVTLPCRVLDQKGPIQWTKDDFGLGAVRNLTGYERYAMIGSDEEGDFSLHIFPVELEDDGKYQCQVSPTDDGQPGLRSRFARLSVLVPPQKPKILQGDFLVTTEDRELTMECISVGGKPAADITWIDGLGNVLHNGIETINEKYEDGPLFTVRSILKVMPRKEHDNTTFTCQSQNAADRTPQNAKLRVEVRYAPKVSLKISSGLSKSGQIVEGSELRFKCRAEANPPEMEYRWYINEKTVIGDYTTEMIIHNATRELHDAIVKCEVHNEVGKSEETETLDITYGPQFRRPPISVETHYGATEILQCDVDGNPTPEILWIHEESDRTVATSPNISVVVSPETAGRYYCKAHVPGFPQLIGYANILIRAPPSIVSQRIQYVPDEGVVKVKCTAISVPKAESVVWSFAGREFNFSFNNTPFSVQEEYTPERVVSTVTLLEPISTYFGDYNCTVTNSYGTDTVIIKLTTRALIPVDWQLILIIVGLVVCIILIGVIIILILHCRDRIKQPRPRSTQAQENDLQETDSNPDRYRESDRSSNLSDVKADIRAGSSVSNAESVTALDSEGEGSTRGVNALALAGPVPNPMGYRYSADYTEPSFPPKNNDGSNNNGYVPYVDYSRDYMPPNTQGMGASRESLSRIPSSGILASKKIGLSSANLGNNTTQTPPIIDPRFSATYGNPYLRMSAAEQLRHAPHTAIPGVTPAPPPYTQAMRMNSLNTLNGAGPQAPLSAHYITGGPNGGIATVKRTSGIGTLATHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HMX6</accession>
    <name>A0A8J2HMX6_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Gustatory receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HICCMSTLAB_LOCUS11954</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Gustatory receptor which mediates acceptance or avoidance behavior, depending on its substrates.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Cell membrane</location>
            <topology evidence="1 8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the insect chemoreceptor superfamily. Gustatory receptor (GR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5104342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HMX6"/>
    <dbReference type="OrthoDB" id="6478931at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030425">
        <property type="term" value="C:dendrite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043025">
        <property type="term" value="C:neuronal cell body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007635">
        <property type="term" value="P:chemosensory behavior"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008049">
        <property type="term" value="P:male courtship behavior"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050909">
        <property type="term" value="P:sensory perception of taste"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013604">
        <property type="entry name" value="7TM_chemorcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21143:SF123">
        <property type="entry name" value="GUSTATORY RECEPTOR FOR SUGAR TASTE 43A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21143">
        <property type="entry name" value="INVERTEBRATE GUSTATORY RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08395">
        <property type="entry name" value="7tm_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 8 9" id="KW-0675">Receptor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="43"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="86"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="138"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="181"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="303"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="334"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAG5104342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="463" mass="53147" checksum="D62CD090ED8EA416" modified="2022-05-25" version="1">MNKVTKSDLYQGLFPIYHLSKVLGLLPVRFVRQRSDRYLGSIYIIDIVYGVCLLVFFSVAEAWGLWRDLRDGWENSTRLKHQTALNITIGDVTAVALLAAAGVIGAPFRWRHIREMMARLIHADERLGYITPKKTQRFAIILSISTIVFLIILASLDIYSWDLQTKMKRKMPDKGPINYSPLYFFYLQALFTEIQYTIATYNLCERFIRLNKNLENLLKNSKTYLRRDNDLVSEDKFPMTILKSEASGGSNKHDRRLFRTPKISGWTAEERESRDVMDTVIQLITIHASLCDVNKLINKAFGFPMLIVALTALFHLIITPYFLLMEASSDRETFFIIVQCLWCILHVYRVVVVVQPCYATTNESQKTAVLTSQLLTYSWQTEIRKQLEIFSLQILHRPLHFTACGLFSLDRALVTSMASAVTTYLVILLQFQKADDTKDSTNVLRNATLLLKNVSSTGIKLIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HN50</accession>
    <name>A0A8J2HN50_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similar to TOGARAM1: TOG array regulator of axonemal microtubules protein 1 (Homo sapiens)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS9352</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5100036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HN50"/>
    <dbReference type="OrthoDB" id="63891at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005881">
        <property type="term" value="C:cytoplasmic microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21567">
        <property type="entry name" value="CLASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21567:SF87">
        <property type="entry name" value="CRESCERIN-LIKE PROTEIN CHE-12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="457"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="460"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="471"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="500"/>
            <end position="518"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5100036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="583" mass="65051" checksum="08746600BCF1DF77" modified="2022-05-25" version="1">MQIHSSYIIAIIQPNRARESEEDWRARVRGFERIASALRSPSALIAIEPRLGSLLHAVLGCERSCRVAAAGMAVARVVVFGVSEEALKRWLPQVAWGLTRQGGPNAAQIARIAMRKLSPALFLEQLLQPHCIDARNAKTRENALQLLIFSLDQFPSTEFKVENVANKVALMVGDRRRRVRQAALDTLAVLAQIYEPEEVLQAGQRAAKQLKESSDMVAAIRARLARKSLPTVTPDGLVVYGLQISPTVQIATGPDVDWIVAGSGSVSPGTGRVRGQIINMYPRANFEKISEKNNTEENYPSHDGNLAARGIGLHPKSGKPVAWQLVSAASKDENKVINGNHTDKNSFKSDGINGNIKKGLEDSPSPFISSLDSIEDSYGTEAVNISLIKDEKDVIMKLRKTEENFHRRMDEIYSERPYQDIIRLESRIPVAQFRDRDIVVRHSTAYSRRRRTVKMDEYEISSSAPQSSYGQRDDEINRRYRSDRIKRESRGGSDDRGEFISSNRASPQVSPSRDTTSIPVNRRRHTAIQSTSFHPQKYGFSSTIESRCKSVPASYQSPFTGVQTIDSYSRISSSPMVIKMYTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HN77</accession>
    <name>A0A8J2HN77_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Similar to Orai: Calcium release-activated calcium channel protein 1 (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HICCMSTLAB_LOCUS10824</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Orai family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5102056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HN77"/>
    <dbReference type="OrthoDB" id="61124at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015279">
        <property type="term" value="F:store-operated calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002115">
        <property type="term" value="P:store-operated calcium entry"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.140">
        <property type="entry name" value="Calcium release-activated calcium channel protein Orai"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012446">
        <property type="entry name" value="CRAC_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038350">
        <property type="entry name" value="Orai_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31501">
        <property type="entry name" value="CALCIUM RELEASE-ACTIVATED CALCIUM CHANNEL PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31501:SF7">
        <property type="entry name" value="CALCIUM RELEASE-ACTIVATED CALCIUM CHANNEL PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07856">
        <property type="entry name" value="Orai-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="229"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="285"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="316"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG5102056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="375" mass="41731" checksum="D8AE022649E0F80F" modified="2022-05-25" version="1">MSSDHSSNYLSNKDLTSTAEMSPNNSETGIVINSSDKRGRINEETVSGKCSKSTQIDFWQMNWRQTPSYNQVSRNRPLSAGFLSKSHLYSNSNCSIGNSSKSLLYSSQSEVTLSPLKSPKVGNNNNSGKFVAIDIAKISNSPFTTTSSYSTNNLSANHSYCANCCNCNYNNGMSSHSPNLQQNESEGPQGLSWRRLHMSRAKLKATATTSELLTMVELQINEPTEVPEWLFVMFAVCTTVLVSVHIFALMISTYLLPNIEAISKLQISRLITESPHERMRGFIELAWAFSTVLGLFLFLVEIAILCWVKFWDYSFMAAMASTIIVIPVLIVFVAFAVHFYHSLVVFKCEASVTDMEELESIKKHLDNVAVNQSSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HNJ9</accession>
    <name>A0A8J2HNJ9_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS11097</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5102602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HNJ9"/>
    <dbReference type="OrthoDB" id="6340174at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006631">
        <property type="entry name" value="DM4_12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21398">
        <property type="entry name" value="AGAP007094-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21398:SF22">
        <property type="entry name" value="IP12060P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07841">
        <property type="entry name" value="DM4_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00718">
        <property type="entry name" value="DM4_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035283874" evidence="1">
        <location>
            <begin position="24"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5102602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="186" mass="20908" checksum="8AD18A789A316D7B" modified="2022-05-25" version="1">MCHYCIKYNYSFLILIFVNIASGSKVKNVTLAVGRHIRSITYPQGSGMGIFFAISVPLDLPEKSVSMAFYFEANYRLPNDKNLTDCYECYQEENINRKFTYDIIESKLESAGYPGRKCLLRAICEAALNPVTGNGLVGDIIHILFTPSSSKEENLSQEIVDAESNCSCTDYDCPMSLLDIISHYIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HNU8</accession>
    <name>A0A8J2HNU8_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">PRKCA-binding protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="19">Protein interacting with C kinase 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">Protein kinase C-alpha-binding protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="26" type="ORF">HICCMSTLAB_LOCUS11311</name>
    </gene>
    <organism evidence="26 27">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="26" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="20">Probable adapter protein that bind to and organize the subcellular localization of a variety of membrane proteins containing some PDZ recognition sequence. Involved in the clustering of various receptors, possibly by acting at the receptor internalization level. Plays a role in synaptic plasticity by regulating the trafficking and internalization of AMPA receptors. May be regulated upon PRKCA activation. May regulate ASIC1/ASIC3 channel. Regulates actin polymerization by inhibiting the actin-nucleating activity of the Arp2/3 complex; the function is competitive with nucleation promoting factors and is linked to neuronal morphology regulation and AMPA receptor (AMPAR) endocytosis. Via interaction with the Arp2/3 complex involved in regulation of synaptic plasicity of excitatory synapses and required for spine shrinkage during long-term depression (LTD). Involved in regulation of astrocyte morphology, antagonistic to Arp2/3 complex activator WASL/N-WASP function.</text>
    </comment>
    <comment type="subunit">
        <text evidence="23">Monomer and homodimer. Interacts with CXADR. Interacts presynaptically with the glutamate receptors GRIA2, GRIA3, GRIK3, isoform 3 of GRIA4, isoform A of GRM4, GRM7 and GRM8; with NAPA and NAPB; and with BTG2. The interaction with NAPA and NAPB disrupts the interaction with GRIA2, conducting to the internalization of GRIA2. Interacts with PRKCA; with the amine transporters SLC6A2 and SLC6A3; with the channels ASIC1 and ASIC2; with the GTP-binding proteins ARF1 and ARF3; with the ephrin receptor tyrosine kinases EPHA7, EPHB1 and EPHB2; with ERBB2 and through its PDZ domain with the C-terminal tail of PRLHR. Interacts with UNC5A. Interacts (via AH domain) with NCS1/FREQ; in a calcium-dependent manner. Interacts with F-actin and associates with the ARP2/3 complex. Interacts (via PDZ domain) with ARF1 (activated); the interaction blocks Arp2/3 complex inhibition. Interacts with SORCS3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Perinuclear region</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Membrane</location>
            <topology evidence="4">Lipid-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="22">Postsynaptic density</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="21">Synapse</location>
            <location evidence="21">Synaptosome</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="26">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5103041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HNU8"/>
    <dbReference type="OrthoDB" id="5917245at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0014069">
        <property type="term" value="C:postsynaptic density"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098842">
        <property type="term" value="C:postsynaptic early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008021">
        <property type="term" value="C:synaptic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032588">
        <property type="term" value="C:trans-Golgi network membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005543">
        <property type="term" value="F:phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019904">
        <property type="term" value="F:protein domain specific binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005080">
        <property type="term" value="F:protein kinase C binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097062">
        <property type="term" value="P:dendritic spine maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002092">
        <property type="term" value="P:positive regulation of receptor internalization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043113">
        <property type="term" value="P:receptor clustering"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034315">
        <property type="term" value="P:regulation of Arp2/3 complex-mediated actin nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07659">
        <property type="entry name" value="BAR_PICK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06722">
        <property type="entry name" value="PDZ_PICK1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.60:FF:000023">
        <property type="entry name" value="Interacting with PRKCA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.42.10:FF:000073">
        <property type="entry name" value="Interacting with PRKCA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010504">
        <property type="entry name" value="AH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030798">
        <property type="entry name" value="Arfaptin_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037959">
        <property type="entry name" value="PICK1_BAR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12141">
        <property type="entry name" value="ARFAPTIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12141:SF1">
        <property type="entry name" value="PRKCA-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06456">
        <property type="entry name" value="Arfaptin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01015">
        <property type="entry name" value="Arfaptin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50870">
        <property type="entry name" value="AH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="15" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="11" id="KW-0106">Calcium</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="16" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="17" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-0564">Palmitate</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0770">Synapse</keyword>
    <keyword evidence="8" id="KW-0771">Synaptosome</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="PDZ" evidence="24">
        <location>
            <begin position="22"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="AH" evidence="25">
        <location>
            <begin position="144"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00031097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00032804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00033721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00034102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00034105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00093501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS50870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="EMBL" id="CAG5103041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="408" mass="46188" checksum="5908159A2C096989" modified="2022-05-25" version="1">MEFDDDFLFEQDKMGMIITSGNVTIRKNPSNLIGISIGGGSPYCPCLYIVQVFDNTPAALEGTLQSGDELCSVNGISVKGKTKEDVAAMIQSSGNQVSINYNKLHADPRQGRTLDIALKKVKHRLVESMGSATADALGLSRAILCNDALVQKLITLQRTESLYKDLVAHAKSMLHAFFDLIQIHKVFGDAFVSIGVREPQPRASEAFRKFGEQHRQIEKFGKLMLKMLKPILSDLGTYLHKVIPDTRLTISKYADAKFEYLSYCLKVKELDDEEQSYIALQEPLYRVETGNYEYRLVLRCRQDARLKFAKQRSDVLVKLELLDNKHVQDIVWQFQKFASSLSSYYSKTQSLLSTTSLFPVEVDLTRSAFHYKLSEQQIVTEEDLYSDAELRNEDDENKINPILGIDTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HNY9</accession>
    <name>A0A8J2HNY9_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS11402</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5103223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HNY9"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035146015" evidence="2">
        <location>
            <begin position="23"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="112"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5103223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="127" mass="13828" checksum="1CF177E977F6AA0E" modified="2022-05-25" version="1">MASTTTLAILMALATQTIYTNAAAYGYGGAAGYGSSQGSSQSHHDTHSIDSDRYPENDDSVRRPTHSSRNDDSVWQSNDRDENSRQHGHGGYQSGNWESGRHSSENIERGHQSGYGQQSGKSSYGHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HP24</accession>
    <name>A0A8J2HP24_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Alpha-mannosidase</fullName>
            <ecNumber evidence="17">3.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">HICCMSTLAB_LOCUS10064</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="15">Catalyzes the first committed step in the biosynthesis of complex N-glycans. It controls conversion of high mannose to complex N-glycans; the final hydrolytic step in the N-glycan maturation pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>N(4)-{beta-D-GlcNAc-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + 2 H2O = 2 alpha-D-mannopyranose + an N(4)-{beta-D-GlcNAc-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc}-L-asparaginyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:56052"/>
            <dbReference type="Rhea" id="RHEA-COMP:14368"/>
            <dbReference type="Rhea" id="RHEA-COMP:14369"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28729"/>
            <dbReference type="ChEBI" id="CHEBI:60615"/>
            <dbReference type="ChEBI" id="CHEBI:60625"/>
            <dbReference type="EC" id="3.2.1.114"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="17">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="17">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer; disulfide-linked.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 17">Belongs to the glycosyl hydrolase 38 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.-" evidence="17"/>
    <dbReference type="EMBL" id="CAJNRD030001122">
        <property type="protein sequence ID" value="CAG5100991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HP24"/>
    <dbReference type="OrthoDB" id="10261055at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004572">
        <property type="term" value="F:mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006013">
        <property type="term" value="P:mannose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006491">
        <property type="term" value="P:N-glycan processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10809">
        <property type="entry name" value="GH38N_AMII_GMII_SfManIII_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.50:FF:000001">
        <property type="entry name" value="Alpha-mannosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.110.10:FF:000003">
        <property type="entry name" value="Alpha-mannosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1180:FF:000019">
        <property type="entry name" value="Alpha-mannosidase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.110.10">
        <property type="entry name" value="Glycoside hydrolase 38, N terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.50">
        <property type="entry name" value="Glycoside hydrolase family 38, central domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.30">
        <property type="entry name" value="Golgi alpha-mannosidase II, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011682">
        <property type="entry name" value="Glyco_hydro_38_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015341">
        <property type="entry name" value="Glyco_hydro_38_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037094">
        <property type="entry name" value="Glyco_hydro_38_cen_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000602">
        <property type="entry name" value="Glyco_hydro_38_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027291">
        <property type="entry name" value="Glyco_hydro_38_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028995">
        <property type="entry name" value="Glyco_hydro_57/38_cen_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050843">
        <property type="entry name" value="Glycosyl_Hydrlase_38"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11607">
        <property type="entry name" value="ALPHA-MANNOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11607:SF3">
        <property type="entry name" value="LYSOSOMAL ALPHA-MANNOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09261">
        <property type="entry name" value="Alpha-mann_mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07748">
        <property type="entry name" value="Glyco_hydro_38C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01074">
        <property type="entry name" value="Glyco_hydro_38N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00872">
        <property type="entry name" value="Alpha-mann_mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88688">
        <property type="entry name" value="Families 57/38 glycoside transferase middle domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="14 17" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="11" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7 17" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8 17" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Glycoside hydrolase family 38 central" evidence="18">
        <location>
            <begin position="449"/>
            <end position="527"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00059516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00093232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU361199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="SMART" id="SM00872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="CAG5100991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="871" mass="101191" checksum="82FC68DB6D65BC64" modified="2022-05-25" version="1">MKSSIHRNYQLFPGFHNGKILACFFMNFLLFSPKFGLGKPSSCPLQSNGQCINSRNDQTRNYFVNNSSNNQLDWKESLTCSFGMNVVPQNDIQMLNLYRELEFDDSYGGVWDQGFDITYSPNQWSPTNKLKIFVVPHSHNDPGWLITFEEYYKESTRNILNNMVVKLPEDKRRKFIWAEISFFKLWWDEQSEEIHEIVRKLIADGQLEIVSGGWVMPDEAVSHWMAQLTQLTEGHQWLKKNLNYRPTSSWAIDPFGLSPTMPYLLKNSGFDNVLIQRVHYAVKKRFAQDKTLEFRWRQLWDTTGSTEIFTHMMPFSSYSIEKTCGPNPYVCVQFDFSKPYSEEITDENVAERASLLLDQYRKKSQLYKTNVVLVPLGDDFRYNKSFEWDAQYNNYQKLFDYMNANTCLNVDVKFGTLTDYFTAVRSEKEISEFPSLSGDFFTYSDKHRYYWSGYYTSRPFHKRLDRMLLGALRRAEIISAIALIHGHQQDFGERIIKARELHSLFQHHDGITGTARDHVVVDYADKMLGALKNLDVVTQQSAAHLLKNTTIPNLYHESAYLSLDEVRYHHKDIKERKILKLNRNETFKKVIIYNSLPRQRTKVQTLIVSTPFVQVVNRNGDQLQCQISPVWVGSEIYSREKYELSFLVTVPGFGLEVYSIFFIEGDKLPENVYLADVTLFNTVVPLSNKFESKDIKIFPSAQEFSITQQNISASFAKSGLLKSIRTGDITTSVDLEFIQYKTFQSGAYLFTPYDAQPNYLYEWDYHVVHLVDGPILSRVFIQLPQVTQTYTLFNSTGSDGLGLHISNHVDITNTFNFELVMRLRTNISSGDEFFTDLNGLNVSKIKKKISIFLYNNTMKKSIIFIKIINLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HP61</accession>
    <name>A0A8J2HP61_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Similar to PDCD6IP: Programmed cell death 6-interacting protein (Homo sapiens)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">HICCMSTLAB_LOCUS13307</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5108578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HP61"/>
    <dbReference type="OrthoDB" id="2141925at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000281">
        <property type="term" value="P:mitotic cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09240">
        <property type="entry name" value="BRO1_Alix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09235">
        <property type="entry name" value="V_Alix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.280:FF:000001">
        <property type="entry name" value="programmed cell death 6-interacting protein-like isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.560">
        <property type="entry name" value="alix/aip1 in complex with the ypdl late domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.50">
        <property type="entry name" value="alix/aip1 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.280">
        <property type="entry name" value="alix/aip1 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025304">
        <property type="entry name" value="ALIX_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004328">
        <property type="entry name" value="BRO1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038499">
        <property type="entry name" value="BRO1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23030">
        <property type="entry name" value="PCD6 INTERACTING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23030:SF39">
        <property type="entry name" value="PROGRAMMED CELL DEATH 6-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13949">
        <property type="entry name" value="ALIX_LYPXL_bnd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03097">
        <property type="entry name" value="BRO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01041">
        <property type="entry name" value="BRO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51180">
        <property type="entry name" value="BRO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BRO1" evidence="3">
        <location>
            <begin position="3"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="707"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="443"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="719"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="738"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="819"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG5108578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="819" mass="91492" checksum="54BE766E382FF207" modified="2022-05-25" version="1" fragment="single">MTELISIPLKKPSDVDVIKPLTNIIKSTYNSATNQKDYTEQISEFSKLRSNALWRAFEKYESSLEVIYSYYDQLCALEGKIPAHELQIPFKWKDAFDRTIFGGKLSLTISTLAYEKLCVLFNIAALQSSVAASQSLDSDEGLKLAAKLFQQAAGIFNYLKGNVMLAIQQEPTPDMSPDTLSALSALMIAQAQEIFVHKAIHDTMKDVVIAKLASQTEEYYAEALKLFQKEIFRSFWDKEWIPLITGKQSGYRAMAELYQASICKSKSAIGEEICRLEYAVDLFKAAQQRSNKPNLFQEYATKAERRLTVIKKDNDFIYHERIPDIKSLEPIGKANIAKFLTMSQPMSSNFKDLFEDLLPVAVHHALSSYEIRRNELVNTEISKLREMTQVLNTVLASLNLPAAIEDTSGTEVPQSLLDKASYVRQAGGIRALETAMNDLPDLLQRNRDILDEAEKMLREERESDDQLREQFKERWTRIPSSKLTEQLTSNAQKYRIIIDNAISADKTVREKFETHREGMEILSLGESELASAIPSGSAVQESGVVIQLRKLMEDVETLKAERDVIESELKSPTVDMKSTFLAALAKDGAIDEPNLSVEQIGKIYGPLTTQVRDSSARQEKLIAEIQSSHAAFTREQSGSGSSREAVLCKLAAAYDAFKELKNNLQEGAKFYNDLTQLLVVFQNKISDFCFARKTEKEELMKDLTTNLSHAGPAATPTIPSHHGAASGPSSAPSESGSTQLPYPTQYQGGMPVPYGASPATPYPTYVPPPMPQTYNPYATMPYPGQGAYNYPQQFPQQPNYVNHYATFPRYGAPPPGQNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HPS1</accession>
    <name>A0A8J2HPS1_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Similar to NKRF: NF-kappa-B-repressing factor (Homo sapiens)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HICCMSTLAB_LOCUS12081</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5106068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HPS1"/>
    <dbReference type="OrthoDB" id="2359216at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.50">
        <property type="entry name" value="R3H-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014720">
        <property type="entry name" value="dsRBD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000467">
        <property type="entry name" value="G_patch_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001374">
        <property type="entry name" value="R3H_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036867">
        <property type="entry name" value="R3H_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021859">
        <property type="entry name" value="XTBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48430">
        <property type="entry name" value="PARTNER OF XRN-2 PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48430:SF1">
        <property type="entry name" value="PARTNER OF XRN-2 PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00035">
        <property type="entry name" value="dsrm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01585">
        <property type="entry name" value="G-patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01424">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11952">
        <property type="entry name" value="XTBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00443">
        <property type="entry name" value="G_patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54768">
        <property type="entry name" value="dsRNA-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82708">
        <property type="entry name" value="R3H domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50137">
        <property type="entry name" value="DS_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50174">
        <property type="entry name" value="G_PATCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51061">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51827">
        <property type="entry name" value="XTBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="XRN2-binding (XTBD)" evidence="6">
        <location>
            <begin position="12"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="DRBM" evidence="3">
        <location>
            <begin position="183"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="G-patch" evidence="4">
        <location>
            <begin position="251"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="domain" description="R3H" evidence="5">
        <location>
            <begin position="301"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="91"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="94"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="121"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAG5106068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="392" mass="44389" checksum="06D54D808652AAFC" modified="2022-05-25" version="1">MSGTSFNTYWDVEKHKLEYECDDHWELRKNFLEAHKDKYPEDQLVCLAQVFTNVELLGCKYPKETMDLVAELSQDVAKEYREKQRSKLQRTFVKASDAASSKAKGHNTTHTDTASTSTSKRCNEDPEEDPSKRMKITSQPFGNLVLLDYPNSSPQMTLDSSVKMSGQRIEWKFHMAQILQCRCEFFINGKKVSEGAGNTKKASKADAAKKGLAILQKYYYTIEIKDDWKVNLTGKQSELKADDPNDNSLQSDGVGAKLMKLMGWAGGGLGKSEQGITEPVTLKRQISRSGFGLKLTSDNMGLFKRKCQQTLSQYIRESDTHNYLVFADFTNDERSIMHDCARRMGLKSQSHGPKHQRTLLITRKLEPSDLVKELLKIGGITDKYILKAPTDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HPX7</accession>
    <name>A0A8J2HPX7_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Alpha-1,3-glucosyltransferase</fullName>
            <ecNumber evidence="10">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">HICCMSTLAB_LOCUS10847</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="pathway">
        <text evidence="2 10">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Endoplasmic reticulum membrane</location>
            <topology evidence="1 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the ALG6/ALG8 glucosyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="10"/>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5102102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HPX7"/>
    <dbReference type="OrthoDB" id="1689333at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042283">
        <property type="term" value="F:dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004856">
        <property type="entry name" value="Glyco_trans_ALG6/ALG8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12413">
        <property type="entry name" value="DOLICHYL GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12413:SF2">
        <property type="entry name" value="DOLICHYL PYROPHOSPHATE GLC1MAN9GLCNAC2 ALPHA-1,3-GLUCOSYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03155">
        <property type="entry name" value="Alg6_Alg8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4 10" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="119"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="142"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="182"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="279"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="309"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="406"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="433"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAG5102102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="489" mass="56269" checksum="0FCA88EA67020716" modified="2022-05-25" version="1">MTKHSNKLSTTTSSKSDHHSTDFEVHRNWLAITYSLPIKEWYVNAKSEWTLDYPPFFAWLEFLFSQIAKFVDPEMLKIDNLNYDSPETIFFQRTTVIIADLMFLYGVREIGKVFCNSQNNFMVFGCLSLCNIGLLMVDHIHFQYNGFLLGILLLSIAKVCKNETPAFIVWLLKWYCFRDNKFFTRLTQLGVIVLTITFVSFGPFLSQLPQVFSRLFPFKRGLVHAYWAANAWALYIGADKILSVISKRFGWVATTKTASMTGGLVQEDTLAILPTPTPLVTFVATLLSILPVIFLILKKKQKHLHREDFVRCIILCALSSFIFGWHVHEKAILTAIIPLSLLATLNKNDGRIFMILSSAGHTAIQPLLFPYDLTLLKILMHFIYSLAEILCFQELFNSSLLKIHEWIYVIILPFITIYETVIHKIIFGQQLPFLPLALTSIYCAIGVIYSWVLYYYVFYTNCTVTDIESSNVKTSQKVQTKVDKIKKRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HQF3</accession>
    <name>A0A8J2HQF3_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">HICCMSTLAB_LOCUS13864</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5109228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HQF3"/>
    <dbReference type="OrthoDB" id="6620644at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035279753" evidence="2">
        <location>
            <begin position="30"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG5109228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="118" mass="13421" checksum="13798BEB0CEAE3B1" modified="2022-05-25" version="1">MARINTHLYKSSILLISVTVVLFSDYTNSKPIQILQNKPGYIGVYIRHGNEPLININPALAEAFHEEINGVIPLEDHEDSVIQKITSDNEKPEKSRNPSNEKNFFIPLPRPYVVHRSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HQK9</accession>
    <name>A0A8J2HQK9_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Dolichyl-phosphate beta-glucosyltransferase</fullName>
            <ecNumber evidence="4">2.4.1.117</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">HICCMSTLAB_LOCUS11365</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>a di-trans,poly-cis-dolichyl phosphate + UDP-alpha-D-glucose = a di-trans,poly-cis-dolichyl beta-D-glucosyl phosphate + UDP</text>
            <dbReference type="Rhea" id="RHEA:15401"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19502"/>
            <dbReference type="ChEBI" id="CHEBI:57525"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="2.4.1.117"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:15402"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyltransferase 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.117" evidence="4"/>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5103149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HQK9"/>
    <dbReference type="OrthoDB" id="3784at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004581">
        <property type="term" value="F:dolichyl-phosphate beta-glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04188">
        <property type="entry name" value="DPG_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000068">
        <property type="entry name" value="ALG5, dolichyl-phosphate beta-glucosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035518">
        <property type="entry name" value="DPG_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10859:SF91">
        <property type="entry name" value="DOLICHYL-PHOSPHATE BETA-GLUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10859">
        <property type="entry name" value="GLYCOSYL TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyltransferase 2-like" evidence="15">
        <location>
            <begin position="67"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00045097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00070518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CAG5103149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="327" mass="37884" checksum="5D12278C41EC5E22" modified="2022-05-25" version="1">MIPLEIISILILILVFTFLAICTYLYINTSRFPKIKRYEEEKSFLNQKTGKREPFPSLHDEFNLHLSVIIPAYNEETRLKPMLDECLEFLENRKKSGLTYEVIVVSDGSTDKTVQVAQNYAKKYDTLRVLELIENRGKGGAVRLGMLSARGSVLLFADADGATKFSDLDKLEDSMKEILNCDYKINPEKVANAHAVVCGSRAHLEEAEAARRSFFRLILMHGFHFLVWTLCVRHVRDTQCGFKLFTRESAKTLFDALHVERWAFDVEILYIAQTLDIPITEIAVNWTEIEGSKIIPFWSWLEMGCDLLLIWLRYKIRAWRIIRPKKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HQT0</accession>
    <name>A0A8J2HQT0_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">2-phosphoxylose phosphatase 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Acid phosphatase-like protein 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HICCMSTLAB_LOCUS13501</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>3-O-[beta-D-GlcA-(1-&gt;3)-beta-D-Gal-(1-&gt;3)-beta-D-Gal-(1-&gt;4)-beta-D-2-O-P-Xyl]-L-seryl-[protein] + H2O = 3-O-(beta-D-GlcA-(1-&gt;3)-beta-D-Gal-(1-&gt;3)-beta-D-Gal-(1-&gt;4)-beta-D-Xyl)-L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:56512"/>
            <dbReference type="Rhea" id="RHEA-COMP:12573"/>
            <dbReference type="Rhea" id="RHEA-COMP:14559"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:132093"/>
            <dbReference type="ChEBI" id="CHEBI:140495"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the histidine acid phosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5108865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HQT0"/>
    <dbReference type="OrthoDB" id="10262962at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050650">
        <property type="term" value="P:chondroitin sulfate proteoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006024">
        <property type="term" value="P:glycosaminoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07061">
        <property type="entry name" value="HP_HAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000560">
        <property type="entry name" value="His_Pase_clade-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050645">
        <property type="entry name" value="Histidine_acid_phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11567:SF110">
        <property type="entry name" value="2-PHOSPHOXYLOSE PHOSPHATASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11567">
        <property type="entry name" value="ACID PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00328">
        <property type="entry name" value="His_Phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00036311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00040357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00041499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAG5108865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="541" mass="61432" checksum="B8ED8319CB562BCF" modified="2022-05-25" version="1">MCKCTLPDTQNPQLIKELARIDSLKDKQQFSKRILALHDVYDTVRGKFLRSLDNSGMLSSLRMYTGKPLSSDVPVREFARHFKPDIKNKRIFKLCNPPDDIKIGSEGKIDGNLTLEGVIIFIRHGDRGPLSHIRNISTVNCAGDFSSNPKLESVYQNYQNFILNSTAYTQSAWSQFLGPFHGFPMLPNNVKECKIGELTTLGIGQLLKTGLILKNAYYNKLNLGNSTVLSKDVVVYSTRYRRTVQSAIALLYSFLLENEVFQNFGKISMRESSSLTFCNTDCACPAAEKFAKQYNKETSDRLKSHPAVIELIKQSSNVVFEMPDQAQTKHPDTLKDALLTYICHGSSLPCVNYESQRICVKTDHVTGLFAYIEWESRLNIKSSNRRKYGLLRAYGLLRNVVSHMVQMISESKPKIVLFSGHDKTLEYLASALGIVVDHAISPHYASRFIIEICRANSKNENHVANDFYFRVIVNGKDVTQTIAFCKNSNYYSGNYGDKNDDGEFLKREYKLCPIEAIIRQLHDDYFLPFNATNFKDACFNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HR14</accession>
    <name>A0A8J2HR14_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Troponin I</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HICCMSTLAB_LOCUS11636</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the troponin I family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001123">
        <property type="protein sequence ID" value="CAG5103691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HR14"/>
    <dbReference type="OrthoDB" id="371899at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005861">
        <property type="term" value="C:troponin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006936">
        <property type="term" value="P:muscle contraction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.350:FF:000004">
        <property type="entry name" value="WupA, isoform I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001978">
        <property type="entry name" value="Troponin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050875">
        <property type="entry name" value="Troponin_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038077">
        <property type="entry name" value="Troponin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13738">
        <property type="entry name" value="TROPONIN I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13738:SF1">
        <property type="entry name" value="TROPONIN I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00992">
        <property type="entry name" value="Troponin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90250">
        <property type="entry name" value="Troponin coil-coiled subunits"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0007">Acetylation</keyword>
    <keyword evidence="4" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0488">Methylation</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="180"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="49"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="188"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00074692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG5103691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="205" mass="24848" checksum="959DF132D218F2C0" modified="2022-05-25" version="1" fragment="single">LQRKRIEDERKRKQAETDRKRAEVRARLEEASKAKKAKKGFMTPERKKKLRLLLRKKAAEELKKEQERKAAERRRIIEQRCGKPRPIEDANEETLKRVLREYHTRICELEDKKFDIEYIVKKKDFEISDLNSQVNDLRGKFMKPTLKKVSKYESKFAKLQKKAAEFNFRNQLKQVKKKEFTLEEEDKEEKPEWVEKRIKEDEVEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HRT6</accession>
    <name>A0A8J2HRT6_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">HICCMSTLAB_LOCUS12135</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5106187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HRT6"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG5106187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="80" mass="9631" checksum="EB291F0DA1B34923" modified="2022-05-25" version="1">MVFLMLILVRKIFISNRRIRRFAEFKALNFTENVFLFQHLRDNDFPSVEKLILDKAVVNNVYDDDLANQFYNGEDHTNNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HRU9</accession>
    <name>A0A8J2HRU9_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mediator of RNA polymerase II transcription subunit 30</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Mediator complex subunit 30</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">HICCMSTLAB_LOCUS13519</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Mediator complex subunit 30 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5108883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HRU9"/>
    <dbReference type="OrthoDB" id="10067025at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021019">
        <property type="entry name" value="Mediator_Med30_met"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31705">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31705:SF4">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11315">
        <property type="entry name" value="Med30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0010">Activator</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="26"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="126"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="79"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="126"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAG5108883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="239" mass="27267" checksum="EBFD88D76AA5C446" modified="2022-05-25" version="1">MAGQQPSFPSGFPAAQQQAMINQFGGGQMVPDLMGPQQGGLPSGLVNPQQFGAGIGGNVGPNPMAQQVMNQQRQQLAQQTLMQQQLQQIQQQQMQLQQQQQQQQQATLVPQNTQVVNQVQTPQASVPQIQPQVPQQQPQVPQQLPQQQQQQQQQQQQQQNKEFNTGMEYTHIESLIPLKEEWDMKSDEKKTSEPYRLACEERKELIDQVTAKNRHLKEIIDHLRRIISEINTMLHMRRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HSQ0</accession>
    <name>A0A8J2HSQ0_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Similar to shf: Protein shifted (Drosophila melanogaster)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">HICCMSTLAB_LOCUS12619</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5107178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HSQ0"/>
    <dbReference type="OrthoDB" id="10266706at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005102">
        <property type="term" value="F:signaling receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2170">
        <property type="entry name" value="Wnt, WIF domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050969">
        <property type="entry name" value="Dev_Signal_Modulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013032">
        <property type="entry name" value="EGF-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003306">
        <property type="entry name" value="WIF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038677">
        <property type="entry name" value="WIF_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14949">
        <property type="entry name" value="EGF-LIKE-DOMAIN, MULTIPLE 7, 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14949:SF32">
        <property type="entry name" value="WNT INHIBITORY FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12661">
        <property type="entry name" value="hEGF"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02019">
        <property type="entry name" value="WIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00469">
        <property type="entry name" value="WIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50814">
        <property type="entry name" value="WIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="7 9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 9" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035272216" evidence="10">
        <location>
            <begin position="18"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="domain" description="WIF" evidence="12">
        <location>
            <begin position="45"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="11">
        <location>
            <begin position="220"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="11">
        <location>
            <begin position="278"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="224"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="242"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="282"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="300"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAG5107178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="354" mass="38999" checksum="1790C1C0F0523BF2" modified="2022-05-25" version="1">MPWVSHVIFAAVAASFASVILHTEQVIARHHRKGNPHKPEGDISLWIDRQQIKMFSGLEMEIYAITEGKVLSYLLDPELENKLPIIPSEVSYVNFTWKSGVKRYYYNFNRLKSLDESILKTPSITIKTKGRVPKRPKEFSILLTCSGNSSGIVQFSIGLVIEKGKGKPLNGTPLRLNLRKECAVRGECVSRAQDHHFSTHTYKPNPGPCPDGYMGPPHCKKALCYPVCMNGGNCTAPGVCSCPPGFQGPYCEGGICTEKCLNGGKCIQKDTCECPKGYFAKCVIPCLNGGKCKGNNICRCPNGFKGDHCEIGRRSPQRSACTRACRNGTCQPDNTCLCDAGWFGKLCNKNKPWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HT77</accession>
    <name>A0A8J2HT77_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Similar to Fip1l1: Pre-mRNA 3'-end-processing factor FIP1 (Rattus norvegicus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">HICCMSTLAB_LOCUS12950</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FIP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5107851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HT77"/>
    <dbReference type="OrthoDB" id="1917198at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005847">
        <property type="term" value="C:mRNA cleavage and polyadenylation specificity factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007854">
        <property type="entry name" value="Fip1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051187">
        <property type="entry name" value="Pre-mRNA_3'-end_processing_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13484">
        <property type="entry name" value="FIP1-LIKE 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13484:SF0">
        <property type="entry name" value="PRE-MRNA 3'-END-PROCESSING FACTOR FIP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05182">
        <property type="entry name" value="Fip1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pre-mRNA polyadenylation factor Fip1" evidence="6">
        <location>
            <begin position="166"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="296"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="15"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="74"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="92"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="308"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="348"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="407"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="469"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="505"/>
            <end position="515"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF05182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAG5107851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="515" mass="58087" checksum="78B26F866B7BAE02" modified="2022-05-25" version="1">MADDNEDQWLYGDSNDGKDNFSKEESLENNKESTSNLNQDELKNIEEGNAENNPEESTEQLEASAPEEHTSQEPNEDEEQEVDENGTKEPSQEDPDAPSDSDSDDDVHVVIGDIKSAPAYNNINIKRSGLLTNASGIPDKLNKQPGKFSIDEFETIGVINGIQAHEFNLDQLEDKPWRQPGADITDYFNYGFNEETWRAYCERQKRMRSESGVGLVLNAGSGGPNLINTRVSQVAITNDNSKYSGIAGPKRAGPPPGRKMAGSIDVIGSSGLASRRNLDKSPPKENVIQVMTADRREYSRKPGFPDMSVPPPGPGMVPPPFDLPPPPAPYQEPPPFYMPEPDPYFQSYEPTQDSQWGNDPTWQPTNLTIPLTASDESKDIGPKSIPTMVPPLVIPPLIASGPPGRDPTARGDNSRGEGEVDSMGRERDRERERDRDRERSERDKDSSVRERERDSVTRDEDKERDRSRSQYRHKERHRHRSRSRSRRHKSRSRSPSRRKKKSRRTDRERSKEESE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2HTP3</accession>
    <name>A0A8J2HTP3_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Similar to Cdcp2: CUB domain-containing protein 2 (Mus musculus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">HICCMSTLAB_LOCUS13269</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001124">
        <property type="protein sequence ID" value="CAG5108501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2HTP3"/>
    <dbReference type="OrthoDB" id="10037824at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00041">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00112">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.290:FF:000065">
        <property type="entry name" value="Uncharacterized protein, isoform E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.290">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000859">
        <property type="entry name" value="CUB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002172">
        <property type="entry name" value="LDrepeatLR_classA_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053207">
        <property type="entry name" value="Non-NMDA_GluR_Accessory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035914">
        <property type="entry name" value="Sperma_CUB_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47537:SF3">
        <property type="entry name" value="CUB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47537">
        <property type="entry name" value="CUBILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00431">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00042">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00192">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49854">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01180">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="944"/>
            <end position="971"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="5">
        <location>
            <begin position="244"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="465"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="725"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="743"/>
            <end position="758"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAG5108501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="1048" mass="117885" checksum="020860AC38CD7114" modified="2022-05-25" version="1">MLVIRRLLIVGVLAASIGHYPVAAATGSKIGGMWWWWRPPWFISYLGFALIFHTTPDVASYHIAVTTSSSSSSQKTDLTAAGCRLSEFRSCNRTLYGDVGRTYEVEVRRPREDRLPFICHINFTAAGGDFGDLVQLTFDTFTVGRFLSFTNQGCPDGFMMIREEGRPATGGQWCGSAWGYTVYYSETASINLTLYLARLSEQGIGYNFDFKLSYKFLKRSEAHLRYGNNTLSTWRGDLVNGTYCDRVLTRCDTRACRLQSPNYPGVYPRNVTCYYRIEHKRAPPGHRALLAVNQRNSHKIHIKDQVVKYDRSQRILRVWDQCNVVQDYLTVYDGGSTTDRVLVRLCGGDTVPDIVSSRNTMLLEFHTSPYDNPFHPVPLSFLPGFELEVHVLFVDDKSRSFVKENSNCDFYITSYENPSGTLENPKHSLPPNTTCRYHFHGKPNEIVWISFIKYYSASTDPPPAASIDSLNNDDDSNNNNNDDLLRNSSRHTRPCSLAESYVSTGRDLTLEHILRQGSALYPISFVLRYEFVHNSMSCHLVFTSSSSFSFSSSFLGGSSRHDESVVKKSAGISGKFSSPKNVFLYGRGGAQNLSCVYRFEAEQDQKVEISISRASFGDKVCMSYVDPLVNRWTCDRRTSDVKLTGLAELVVSEYPWPGVKLVRDCFCSNITGNADNDSSNNNYRVSLTSLTSNIVELKFTITRMNVTQDYNDFFFEGEYRFVSNNVPVENNEDSDDTRNHGNEDDDDDDDDDDNNSDNEEQKLQKRQQQQSRRRCPSRLEDRKLRGTSGEISLKSPLLSVRHYDGSDFGKTTGSDVAAVEEILKNTDDLTTTAIATQHSPITQQHARSFVVEFIQKEPGTYSVMWIAISKSARAATDTHYFNTDGDNSAGNIFSMVPPIEDCPYRCPEIKACISSVLWCDGIKHCPSGFDEEEINCSYRFGVTLLYVAVGAGILGVFLVLLLATGCLKYCLYRHKIRTKKKKKKKKNSLNSLNVNNIHVNHMHHHHNNGLTSSSQLQSGGGGAGGQYNITSHPQDLYTSDNYGKDSIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MCY5</accession>
    <name>A0A8J2MCY5_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Nucleolar GTP-binding protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">HICCMSTLAB_LOCUS3443</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Involved in the biogenesis of the 60S ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
            <location evidence="1 6">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. NOG subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001118">
        <property type="protein sequence ID" value="CAG5082044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MCY5"/>
    <dbReference type="OrthoDB" id="415015at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01897">
        <property type="entry name" value="NOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000496">
        <property type="entry name" value="Nucleolar GTP-binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1190">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031167">
        <property type="entry name" value="G_OBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024926">
        <property type="entry name" value="NOG1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041623">
        <property type="entry name" value="NOG1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010674">
        <property type="entry name" value="NOG1_Rossman_fold_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012973">
        <property type="entry name" value="NOG_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45759">
        <property type="entry name" value="NUCLEOLAR GTP-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06858">
        <property type="entry name" value="NOG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17835">
        <property type="entry name" value="NOG1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08155">
        <property type="entry name" value="NOGCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038919">
        <property type="entry name" value="NOG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51710">
        <property type="entry name" value="G_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="OBG-type G" evidence="8">
        <location>
            <begin position="147"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="477"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="513"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="543"/>
            <end position="556"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR038919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAG5082044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="619" mass="71059" checksum="1B53FEE5F4A9CA01" modified="2022-05-25" version="1">MSMYNFKKITVVPTAKDFIDIILSRTQRKTPTVVHKNYKISRIRAFYTRKVKFSQQSFHDRLSKIIQEFPKLDDVHPFYADLMNVFVAKDYVRLLKYGDSLYRCKQLKKAALGRMATIMKRQAANLTYLEQVRQHLARLPSIDPYTRTIIICGFPNVGKSSFINKITRAEVEVQPYAFTTKSLYVGHTDYKYLRWQVIDTPGILDHALEDRNVIEMQAVTALAHLRAAVLYVCDLSEQCGHSLEEQLKLFESIKPLFANKPLMVVANKIDVVGLDELSDDKREVIKKFEEHDIPILAMSTVTEEGVMEVKHEACERLLSFRVDQKVKTKKVEGLLNRLHVAIPAPRDNKVRPPCIPASVLQKKAVAAEKAERKRKLERDIEEEMGDDYILDLKKNYDIEGDQKYDIIPEIWEGHNVADYIDPEIFDKLNELERAEELRIASGIYDYKVPELTETMKDIRAMAQQIREKIAIDKQESLVNKQSTKPVMPRTSVARGRDRSVRKLRDQMEGLGVDMEDTGDAHFTKTRGRSRSLSGPARKKQRVESVVSTSRARSSSRPARDEMGIKDVVMKSKLKNIAHKAIRKKVAKKGLKGEADRFIGTKMPKHLFSGKRGVGKTDRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MFQ2</accession>
    <name>A0A8J2MFQ2_COTCN</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">HICCMSTLAB_LOCUS2486</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001117">
        <property type="protein sequence ID" value="CAG5077521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MFQ2"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG5077521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000786811"/>
        </source>
    </evidence>
    <sequence length="75" mass="8832" checksum="B750DB79D5554DCF" modified="2022-05-25" version="1">MDETGATQRSVRHPINTRETKTTEREIKNNVLSVQKFIKVAKDINRDFGKYGDERCNQLLRQELELTSEIWLPNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-05-25" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8J2MHR3</accession>
    <name>A0A8J2MHR3_COTCN</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">Exocyst complex component 7</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Exocyst complex component Exo70</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">HICCMSTLAB_LOCUS6377</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cotesia congregata</name>
        <name type="common">Parasitoid wasp</name>
        <name type="synonym">Apanteles congregatus</name>
        <dbReference type="NCBI Taxonomy" id="51543"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Hexapoda</taxon>
            <taxon>Insecta</taxon>
            <taxon>Pterygota</taxon>
            <taxon>Neoptera</taxon>
            <taxon>Endopterygota</taxon>
            <taxon>Hymenoptera</taxon>
            <taxon>Apocrita</taxon>
            <taxon>Ichneumonoidea</taxon>
            <taxon>Braconidae</taxon>
            <taxon>Microgastrinae</taxon>
            <taxon>Cotesia</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2021-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chebbi M.A.C M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the EXO70 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAJNRD030001120">
        <property type="protein sequence ID" value="CAG5092801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8J2MHR3"/>
    <dbReference type="OrthoDB" id="1922221at2759"/>
    <dbReference type="Proteomes" id="UP000786811">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000145">
        <property type="term" value="C:exocyst"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005546">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.170">
        <property type="entry name" value="Exocyst complex component Exo70"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016159">
        <property type="entry name" value="Cullin_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004140">
        <property type="entry name" value="Exo70"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046364">
        <property type="entry name" value="Exo70_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12542:SF41">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12542">
        <property type="entry name" value="EXOCYST COMPLEX PROTEIN EXO70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03081">
        <property type="entry name" v
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